-- dump date 20250517_145553 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GeneID -- field 3 chrom_position -- field 4 chromosome -- field 5 codon_start -- field 6 contig -- field 7 description -- field 8 end_pos -- field 9 gene -- field 10 gene_id -- field 11 name -- field 12 organism -- field 13 product -- field 14 protein_id -- field 15 start_pos -- field 16 strand -- field 17 taxid -- field 18 type -- header -- id GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type An09g00010 4983552 complement(4485..5126) I 1 NT_166525.1 Function: the S. cerevisiae Pad1p confers resistance to cinnamic acid.; Similarity: shows similarity to several phenylacrylic acid decarboxylase and 3-octaprenyl-4-hydroxybenzoate carboxy-lyase of different organisms.; Title: strong similarity to phenylacrylic acid decarboxylase Pad1 - Saccharomyces cerevisiae; uncharacterized protein 5126 4983552 An09g00010 Aspergillus niger uncharacterized protein XP_001393326.1 4485 R 5061 CDS An09g00020 84591910 complement(join(5289..5531,5620..5658)) I 1 NT_166525.1 hypothetical protein 5658 84591910 An09g00020 Aspergillus niger hypothetical protein XP_059604237.1 5289 R 5061 CDS An09g00030 4983555 join(5725..6544,6609..7321) I 1 NT_166525.1 Remark: the yigC protein of E. coli has been identified as the ubiD protein.; Title: similarity to ubiquinone biosynthesis protein ubiD - Escherichia coli; See PMID 11029449; See PMID 365223; uncharacterized protein 7321 4983555 An09g00030 Aspergillus niger uncharacterized protein XP_059604238.1 5725 D 5061 CDS An09g00040 84591911 7871..8041 I 1 NT_166525.1 hypothetical protein 8041 84591911 An09g00040 Aspergillus niger hypothetical protein XP_059604239.1 7871 D 5061 CDS An09g00050 84591912 join(9009..9044,9127..9233,9297..9408,9508..9620,9684..9798) I 1 NT_166525.1 Function: the enzyme CYP55A1 from F. oxysporum is involved in fungal denitrification, acting as a nitric oxide reductase.; Function: the expression of CYP55A1 from F. oxysporum is regulated in response to oxygen tension by an fumarate and nitrate reduction-like system.; Remark: ORF contains an internal stop codon, due to a putative point mutation.; Title: similarity to nitric-oxide cytochrome P-450 reductase Cyp55 - Fusarium oxysporum [putative sequencing error]; putative sequencing error; See PMID 2037602; See PMID 7798191; See PMID 9010754; uncharacterized protein 9798 84591912 An09g00050 Aspergillus niger uncharacterized protein XP_059604240.1 9009 D 5061 CDS An09g00060 4983570 complement(join(10314..10353,10530..10538,10738..10944,11011..14404,14525..15056)) I 1 NT_166525.1 Similarity: similarity to several hypothetical and known multidrug resistance proteins and ABC transporters of different organisms.; Title: similarity to multidrug resistance protein MLP-2 - Rattus norvegicus; See PMID 9614210; See PMID 10629898; uncharacterized protein 15056 4983570 An09g00060 Aspergillus niger uncharacterized protein XP_001393331.3 10314 R 5061 CDS An09g00070 4983576 complement(join(15206..15278,15428..15717,16024..16317,16402..16445,16514..16654,16704..16785)) I 1 NT_166525.1 Similarity: N-terminal half shows similarity to several transaminases of eukaryotes and bacteria.; Similarity: shows overall similarity to probable aminotransferases of N. crassa, S. cerevisiae and S. pombe.; Title: similarity to mitochondrial kynurenine aminotransferase KAT - Aedes aegypti; See PMID 12110301; uncharacterized protein 16785 4983576 An09g00070 Aspergillus niger uncharacterized protein XP_059604241.1 15206 R 5061 CDS An09g00080 84591913 join(16792..16864,16952..17052,17529..17570,17737..17866,17953..18056) I 1 NT_166525.1 hypothetical protein 18056 84591913 An09g00080 Aspergillus niger hypothetical protein XP_059604242.1 16792 D 5061 CDS An09g00090 84591914 join(18168..18237,18500..18614,18857..18920,19033..19152) I 1 NT_166525.1 hypothetical protein 19152 84591914 An09g00090 Aspergillus niger hypothetical protein XP_059604243.1 18168 D 5061 CDS An09g00100 4983543 join(19178..19258,19453..20093,20141..20327) I 1 NT_166525.1 Function: Sur1p of S. cerevisiae is required for mannosylation of sphingolipids.; Title: similarity to sphingolipid metabolism Sur1 -Saccharomyces cerevisiae; uncharacterized protein 20327 4983543 An09g00100 Aspergillus niger uncharacterized protein XP_001393335.3 19178 D 5061 CDS An09g00110 84591915 join(20634..20697,20783..20849,21038..21094,21188..21260,21349..21675) I 1 NT_166525.1 hypothetical protein 21675 84591915 An09g00110 Aspergillus niger hypothetical protein XP_059604244.1 20634 D 5061 CDS An09g00120 4983573 complement(join(22340..22724,22782..23242)) I 1 NT_166525.1 Alternative name: FAEA from A. niger was identical to A. niger FAE-III and is probably identical to ferA.; Function: involved in degradation of complex cell wall polysaccharides.; Gene-ID: faeA;ferA; Mapping: faeA from A. niger is mapped to chromosome I; see EMBL Y09330.; See PMID 9406381; ferulic acid esterase A faeA-Aspergillus niger 23242 faeA 4983573 faeA Aspergillus niger ferulic acid esterase A faeA-Aspergillus niger XP_001393337.1 22340 R 5061 CDS An09g00130 84591916 complement(join(23609..23736,23821..>23884)) I 1 NT_166525.1 hypothetical protein [truncated ORF] 23884 84591916 An09g00130 Aspergillus niger hypothetical protein [truncated ORF] XP_059604245.1 23609 R 5061 CDS An09g00140 84591917 join(24580..24918,25006..25071,25155..25223) I 1 NT_166525.1 hypothetical protein 25223 84591917 An09g00140 Aspergillus niger hypothetical protein XP_059601285.1 24580 D 5061 CDS An09g00150 84591918 join(27488..27552,27943..28009,28181..28366) I 1 NT_166525.1 Remark: blast hit not significant. ORF might be questionable.; hypothetical protein 28366 84591918 An09g00150 Aspergillus niger hypothetical protein XP_059601286.1 27488 D 5061 CDS An09g00160 4983544 28425..29297 I 1 NT_166525.1 Function: potential methyltransferase.; Similarity: shows similarity to hypothetical protein SPAC1B3. 06c of S. pombe, which belongs to the methyltransferase ubiE family.; Similarity: similiar proteins seem to be expressed in Streptomyces coelicolor and S. pombe.; Title: similarity to hypothetical protein Rv0839 -Mycobacterium tuberculosis; uncharacterized protein 29297 4983544 An09g00160 Aspergillus niger uncharacterized protein XP_001393341.1 28425 D 5061 CDS An09g00170 4983571 complement(join(29830..31383,31434..31580)) I 1 NT_166525.1 Catalytic activity: alpha-isopropylmalate synthase catalyzes the conversion of 3-Carboxy-3-hydroxy-4-methylpentanoate + CoA = Acetyl-CoA + 3-Methyl-2-oxobutanoate + H2O.; Function: alpha-isopropylmalate synthase catalyzes the first step in leucine biosynthesis pathway.; Remark: LEU4 of S. cerevisiae has the systematic name of YNL104C.; Remark: enzyme in S. cerevisiae shows alternative splicing but the putative protein in A. niger is shorter than the yeast short form.; Remark: the two alternatively spliced forms of LEU4 of S. cerevisiae code for the cytoplasmic and the mitochondrial forms of alpha-isopropylmalate synthase.; Title: strong similarity to alpha-isopropylmalate synthase Leu4 - Saccharomyces cerevisiae; See PMID 2420798; uncharacterized protein 31580 4983571 An09g00170 Aspergillus niger uncharacterized protein XP_001393342.3 29830 R 5061 CDS An09g00180 84591919 complement(join(31914..32016,32122..32336)) I 1 NT_166525.1 hypothetical protein 32336 84591919 An09g00180 Aspergillus niger hypothetical protein XP_059601287.1 31914 R 5061 CDS An09g00190 4983563 join(32490..32616,32652..33916,33965..34014,34195..34213) I 1 NT_166525.1 Localization: probable integral membrane protein.; Phenotype: null mutant QDR1 of S. cerevisiae is viable, but exhibits higher susceptibility to quinidine (SGD database).; Remark: the systematic name for QDR1 of S. cerevisiae is YIL120W.; Similarity: belongs to the CAR1/CYHR subfamily.; Similarity: belongs to the major facilitator family (also known as the drug resistance translocase family).; Title: similarity to multidrug resistance protein Qdr1 - Saccharomyces cerevisiae; See PMID 11302822; uncharacterized protein 34213 4983563 An09g00190 Aspergillus niger uncharacterized protein XP_059601288.1 32490 D 5061 CDS An09g00200 4983559 complement(join(34616..34886,34971..35044,35424..35468,35543..36126,36168..36404,36617..36677,36778..36906,37033..37095)) I 1 NT_166525.1 Remark: blast hits show weak similarity to partial sequence of oncogene 1 (tre-2 locus) (clone 210) and transforming protein (clone 213) - human.; hypothetical protein 37095 4983559 An09g00200 Aspergillus niger hypothetical protein XP_059601289.1 34616 R 5061 CDS An09g00210 84591920 join(37122..37168,37491..37715,37755..37810,37872..37941,38047..38110,38197..38295,38360..38435,38655..38743) I 1 NT_166525.1 Remark: blastp hit show very weak similarity to cytochrome P450 1A-61, polyaromatic hydrocarbon-inducible,hepatic - chicken.; hypothetical protein 38743 84591920 An09g00210 Aspergillus niger hypothetical protein XP_059601290.1 37122 D 5061 CDS An09g00220 10098202 complement(join(38904..39415,39476..39675,39742..39868,40165..40294,40370..40540)) I 1 NT_166525.1 Catalytic activity: omtB of A. parasiticus catalyzes the conversion of demethylsterigmatocystin (DMST) to sterigmatocystin (ST) and dihydrodemethylsterigmatocystin (DHDMST) to dihydrosterigmatocystin (DHST).; Pathway: omtB of A. parasiticus is a component of the aflatoxin biosynthesis gene cluster.; Remark: aflatoxins are polyketide-derived secondary metabolites; Similarity: shows similarity to several fungal and bacterial O-methyl transferases.; Title: strong similarity to O-methyltransferase omtB - Aspergillus flavus; See PMID 10806361; uncharacterized protein 40540 10098202 An09g00220 Aspergillus niger uncharacterized protein XP_059601291.1 38904 R 5061 CDS An09g00230 84591921 complement(40962..41612) I 1 NT_166525.1 Remark: blast hits result from similarities to the carboxyterminal part of O-methyltransferase B of Aspergillus spec.; Title: weak similarity to O-methyltransferase omtB -Aspergillus flavus; See PMID 10806361; uncharacterized protein 41612 84591921 An09g00230 Aspergillus niger uncharacterized protein XP_059601292.1 40962 R 5061 CDS An09g00250 84591922 join(42816..42922,43409..43531,43655..43701,43865..44073) I 1 NT_166525.1 Remark: similarity to domains of aldehyd dehydrogenases of various species - S. pombe, A. globiformis, E. coli. Sequence contains possible sequencing errors, bad quality sequence that might have affected the gene prediction.; Title: weak similarity to hypothetical aldehyde dehydrogenase CAB63554.1 - Schizosaccharomyces pombe; uncharacterized protein 44073 84591922 An09g00250 Aspergillus niger uncharacterized protein XP_059601293.1 42816 D 5061 CDS An09g00260 4983539 join(45217..45313,45391..45997,46051..>47136) I 1 NT_166525.1 Catalytic activity: alpha-galactosidase catalyzes the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.; Expression: expression of aglC was only observed on glucose, fructose, and combinations of glucose with xylose and galactose.; Gene-ID: aglC; Mapping: aglC from A. niger is mapped to chromosome II; see list from DSM.; Remark: partial CDS due to contig border, contains aminoterminus of algC, contig linked to contig An09c0030 but with a gap of about 200 bp,sequence ambiguities (contains N's) and possible sequencing errors (bad quality).; See PMID 10347026; alpha-galactosidase aglC-Aspergillus niger [truncated ORF] 47136 aglC 4983539 aglC Aspergillus niger alpha-galactosidase aglC-Aspergillus niger [truncated ORF] XP_001393350.3 45217 D 5061 CDS An09g00270 84591923 <47327..47689 I 1 NT_166525.1 Catalytic activity: alpha-galactosidase catalyzes the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.; Expression: expression of aglC was only observed on glucose, fructose, and combinations of glucose with xylose and galactose.; Gene-ID: aglC; Mapping: aglC from A. niger is mapped to chromosome II; see list from DSM.; Remark: carboxyterminal part of algC.; Remark: linked to the adjacent contig An09c0020 but with a gap of about 200 bp, sequence ambiguities (contains N's),; Remark: partial CDS due to contig border.; See PMID 10347026; alpha-galactosidase aglC-Aspergillus niger [truncated ORF] 47689 aglC 84591923 aglC Aspergillus niger alpha-galactosidase aglC-Aspergillus niger [truncated ORF] XP_059606676.1 47327 D 5061 CDS An09g00280 84591924 join(48152..48284,48367..48519,48603..48699,48941..49076,49127..49225,49541..49684) I 1 NT_166525.1 hypothetical protein 49684 84591924 An09g00280 Aspergillus niger hypothetical protein XP_059606677.1 48152 D 5061 CDS An09g00290 84591925 join(50244..50355,50410..50612) I 1 NT_166525.1 Title: weak similarity to hypothetical protein encoded by An03g03440 - Aspergillus niger; uncharacterized protein 50612 84591925 An09g00290 Aspergillus niger uncharacterized protein XP_059606678.1 50244 D 5061 CDS An09g00300 84591926 join(51146..51412,51499..51534,51842..52051,52121..52313,52571..52756,52867..53039) I 1 NT_166525.1 hypothetical protein 53039 84591926 An09g00300 Aspergillus niger hypothetical protein XP_059606679.1 51146 D 5061 CDS An09g00310 4983557 join(53537..53702,53759..53843,53901..53949,54017..54145,54198..54231,54284..54541,54592..55376) I 1 NT_166525.1 Catalytic activity: acid phosphatases catalyze the conversion of orthophosphoric monoester + H2O = alcohol + orthophosphate.; Similarity: shows similarity to several yeast acid phosphatases.; Title: similarity to constitutive acid phosphatase Ph03 - Saccharomyces cerevisiae; See PMID 6093051; uncharacterized protein 55376 4983557 An09g00310 Aspergillus niger uncharacterized protein XP_001393355.1 53537 D 5061 CDS An09g00320 4983569 complement(join(55848..56370,56426..56696,56778..56892)) I 1 NT_166525.1 hypothetical protein 56892 4983569 An09g00320 Aspergillus niger hypothetical protein XP_001393356.1 55848 R 5061 CDS An09g00330 84591927 complement(join(57015..57170,57423..57535,57642..57766,57827..57918)) I 1 NT_166525.1 hypothetical protein 57918 84591927 An09g00330 Aspergillus niger hypothetical protein XP_059606680.1 57015 R 5061 CDS An09g00340 84591928 complement(join(58568..58790,58850..59037,59080..59122,59193..59500)) I 1 NT_166525.1 hypothetical protein 59500 84591928 An09g00340 Aspergillus niger hypothetical protein XP_059606681.1 58568 R 5061 CDS An09g00350 84591929 60211..60885 I 1 NT_166525.1 hypothetical protein 60885 84591929 An09g00350 Aspergillus niger hypothetical protein XP_059606682.1 60211 D 5061 CDS An09g00360 4983560 complement(61605..63338) I 1 NT_166525.1 Title: similarity to hypothetical protein encoded by An07g04880 - Aspergillus niger; uncharacterized protein 63338 4983560 An09g00360 Aspergillus niger uncharacterized protein XP_001393360.1 61605 R 5061 CDS An09g00370 84591930 complement(join(64434..64783,64955..64964)) I 1 NT_166525.1 hypothetical protein 64964 84591930 An09g00370 Aspergillus niger hypothetical protein XP_059606683.1 64434 R 5061 CDS An09g00380 4983542 join(65415..66697,66767..67699,67765..68288,68347..69782) I 1 NT_166525.1 Remark: ankyrin repeats are often contained in other proteins (which are not classified with the ankyrin family) and ensure protein-protein interactions as well as interactions between proteins and nucleic acids.; Remark: ankyrins are a family of adapter molecules that mediate linkages between integral membrane and cytoskeletal proteins and are involved in distribution of membrane proteins in transporting epithelia.; Similarity: shows similarity to several ankyrin-repeat containing proteins of different organisms.; Title: weak similarity to ankyrin 3 (splice form 2) - Mus musculus; uncharacterized protein 69782 4983542 An09g00380 Aspergillus niger uncharacterized protein XP_001393362.1 65415 D 5061 CDS An09g00390 4983572 complement(join(69953..70804,70860..71396)) I 1 NT_166525.1 Remark: shows similarity to probable oxidoreductases of various bacteria (Streptomyces coelicolor, Pseudomonas aeruginosa, Neisseria meningitidis).; Title: similarity to hypothetical conserved protein PA2776 - Pseudomonas aeruginosa; uncharacterized protein 71396 4983572 An09g00390 Aspergillus niger uncharacterized protein XP_001393363.1 69953 R 5061 CDS An09g00400 4983577 join(71632..71800,71854..>73461) I 1 NT_166525.1 Function: dicarboxylic amino-acid permease Dip5 of S. cerevisiae belongs to the DAACS family of transporters (TC 2. A. 23, Na+ or H+ symporter).; Remark: DIP5 of S. cerevisae has a systematic name of YPL265W.; Remark: possible sequencing error around pos. 21039 of the contig.; Remark: prnB of A. nidulans is part of the major proline transport system.; Similarity: shows also strong similarity to proline transporter prnB of A. nidulans and several other amino-acid transporter proteins of various organisms.; Title: strong similarity to dicarboxylic amino acid permease Dip5 - Saccharomyces cerevisiae; plasma membrane; putative frameshift; See PMID 8437566; See PMID 9508791; See PMID 2664423; uncharacterized protein 73461 4983577 An09g00400 Aspergillus niger uncharacterized protein XP_059606684.1 71632 D 5061 CDS An09g00410 84591931 complement(join(73738..73836,73926..74019,74068..74087)) I 1 NT_166525.1 hypothetical protein 74087 84591931 An09g00410 Aspergillus niger hypothetical protein XP_059606685.1 73738 R 5061 CDS An09g00420 4983579 74108..74830 I 1 NT_166525.1 Catalytic activity: (S)-2-haloacid + H(2)O <=> (R)-2-hydroxyacid + halide.; Remark: HADs belong to a large superfamily of hydrolases with diverse substrate specificity, which also includes epoxide hydrolases, phosphoglycolate phosphatases,histidinol phosphate phosphatases, nitrophenyl phosphatases and numerous putative (not yet characterised) proteins.; Similarity: 2-haloacid halidohydrolase IVa of B. cepacia belongs to the 2-haloalkanoid acid dehalogenases.; Title: similarity to 2-haloacid halidohydrolase IVa - Burkholderia cepacia; See PMID 1376111; uncharacterized protein 74830 4983579 An09g00420 Aspergillus niger uncharacterized protein XP_001393366.1 74108 D 5061 CDS An09g00430 4983580 complement(join(74897..75803,75854..76024,76071..76752,76806..77090,77146..77272)) I 1 NT_166525.1 Similarity: the PrnA protein of A. nidulans belongs to the Zn binuclear cluster family of transcriptional activators and is involved in proline utilization as a nitrogen and/or carbon source.; Similarity: the similarity spans only aa 14-640, the C-terminal part shows no similarity to prnA of A. nidulans.; Title: strong similarity to transcription activator prnA - Aspergillus nidulans; nucleus; See PMID 9622360; uncharacterized protein 77272 4983580 An09g00430 Aspergillus niger uncharacterized protein XP_059606686.1 74897 R 5061 CDS An09g00440 10098208 complement(join(77416..77571,77829..78006,78321..78528,78882..79160,79207..79253,79404..79493,79577..79612,79706..79776)) I 1 NT_166525.1 Title: weak similarity to hypothetical protein encoded by An11g03090 - Aspergillus niger; uncharacterized protein 79776 10098208 An09g00440 Aspergillus niger uncharacterized protein XP_059606687.1 77416 R 5061 CDS An09g00450 4983581 complement(join(80376..83024,83075..83476,83541..83843)) I 1 NT_166525.1 Remark: LYS2 of S. cerevisiae has a systematic name of YBR115C.; Remark: shows better overall similarity to probable acyl-CoA synthase fadD9 of M. tuberculosis.; Similarity: similarity to S. cerevisiae LYS2 is restricted to C-terminal part.; Title: weak similarity to L-aminoadipate-semialdehyde dehydrogenase Lys2 -Saccharomyces cerevisiae; uncharacterized protein 83843 4983581 An09g00450 Aspergillus niger uncharacterized protein XP_001393369.1 80376 R 5061 CDS An09g00460 84591932 join(84473..84598,84685..84896,85250..85349) I 1 NT_166525.1 hypothetical protein 85349 84591932 An09g00460 Aspergillus niger hypothetical protein XP_059606688.1 84473 D 5061 CDS An09g00470 4983584 complement(86662..87882) I 1 NT_166525.1 Similarity: shows weak similarity to proteins containing the abhydrolase domain of various species (H. sapiens, C. elegans, E. coli, M. tuberculosis).; Title: similarity to bladder tumour EST encoded protein 16 from patent DE19818619-A1 - Homo sapiens; uncharacterized protein 87882 4983584 An09g00470 Aspergillus niger uncharacterized protein XP_001393371.1 86662 R 5061 CDS An09g00480 4983585 join(88737..88781,88851..89336,89418..89598,89667..89836,89896..89946) I 1 NT_166525.1 Title: similarity to BCU0021 protein SEQ ID 8 from patent WO2003029421-A2 - Homo sapiens.; uncharacterized protein 89946 4983585 An09g00480 Aspergillus niger uncharacterized protein XP_059606689.1 88737 D 5061 CDS An09g00490 84591933 complement(join(90318..90384,90511..90597,90638..90735,90809..90891,90980..91061)) I 1 NT_166525.1 hypothetical protein 91061 84591933 An09g00490 Aspergillus niger hypothetical protein XP_059606690.1 90318 R 5061 CDS An09g00500 4983587 join(91167..91969,92261..92521,92574..94134) I 1 NT_166525.1 Function: ARG81 of S. cerevisiae is a regulator of arginine-responsive genes with ARG80 and ARG82; Remark: ARG81 of S. cerevisiae is also known as ARGR2 and has a systematic name of YML099C.; Similarity: shows matches only against the Zn(2)-Cys(6) motif of several hypothetical proteins and known transcription factors.; Title: weak similarity to transcription factor Arg81 - Saccharomyces cerevisiae; uncharacterized protein 94134 4983587 An09g00500 Aspergillus niger uncharacterized protein XP_001393374.3 91167 D 5061 CDS An09g00510 4983588 join(94676..94847,94902..94964,95019..95341) I 1 NT_166525.1 Title: strong similarity to hypothetical protein encoded by An01g01630 - Aspergillus niger; uncharacterized protein 95341 4983588 An09g00510 Aspergillus niger uncharacterized protein XP_001393375.1 94676 D 5061 CDS An09g00520 4983589 complement(95688..100331) I 1 NT_166525.1 Function: the cyclic decapeptide antibiotic tyrocidine is produced by Bacillus brevis ATCC 8185 on an enzyme complex comprising three peptide synthetases, TycA,TycB, and TycC (tyrocidine synthetases 1, 2, and 3), via the nonribosomal pathway.; Similarity: shows similarity to internal part only.; Title: similarity to tyrocidine synthase 2 tycB -Brevibacillus brevis; See PMID 9352938; uncharacterized protein 100331 4983589 An09g00520 Aspergillus niger uncharacterized protein XP_001393376.1 95688 R 5061 CDS An09g00530 4983590 join(101052..101082,101133..102009,102083..102482) I 1 NT_166525.1 Function: the nahG and nahW genes of P. stutzeri AN10 are induced and expressed upon incubation with salicylate, and the enzymes that are encoded, NahG and NahW, are involved in naphthalene and salicylate metabolism.; Title: similarity to salicylate hydroxylase nahW -Pseudomonas stutzeri; See PMID 10197990; uncharacterized protein 102482 4983590 An09g00530 Aspergillus niger uncharacterized protein XP_001393377.1 101052 D 5061 CDS An09g00540 4983591 complement(join(103348..103448,103501..103702,103758..103882,103933..104131)) I 1 NT_166525.1 hypothetical protein 104131 4983591 An09g00540 Aspergillus niger hypothetical protein XP_001393378.1 103348 R 5061 CDS An09g00550 4983592 join(104951..105561,105612..106919,106989..107067) I 1 NT_166525.1 Function: S. pombe enzyme plays a role in the entry into G0, possibly by facilitating the release of a signaling substance into the environment as a means of cell-to-cell communication.; Remark: is longer than all other protein, might be due to sequencing error.; Similarity: fnx1(+) encodes a protein with sequence similarity to the proton-driven plasma membrane transporters from the multidrug resistance group of the major facilitator superfamily of proteins.; Title: similarity to multidrug resistance protein fnx1p - Schizosaccharomyces pombe; See PMID 9710608; uncharacterized protein 107067 4983592 An09g00550 Aspergillus niger uncharacterized protein XP_059606691.1 104951 D 5061 CDS An09g00560 4983593 join(107626..107745,107782..107981,108031..109231,109297..109341) I 1 NT_166525.1 Function: enzyme of G. gallus catalyzes the hydroxylation of 25-hydroxyvitamin D3 to 24,25-dihydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 to 1,24, 25-trihydroxivitamin D3.; Title: similarity to mitochondrial 25-hydroxyvitamin D3 24-hydroxylase cP450cc24 - Gallus gallus; See PMID 9512657; uncharacterized protein 109341 4983593 An09g00560 Aspergillus niger uncharacterized protein XP_059606692.1 107626 D 5061 CDS An09g00570 4983594 join(110344..110413,110483..110557,110659..111182) I 1 NT_166525.1 Title: weak similarity to calcium binding protein P22 - Gallus gallus; See PMID 7769011; uncharacterized protein 111182 4983594 An09g00570 Aspergillus niger uncharacterized protein XP_001393381.1 110344 D 5061 CDS An09g00580 4983595 join(112176..112742,112795..114450,114519..114692) I 1 NT_166525.1 Function: those proteins are mostly involved in transcriptional control.; Similarity: shows similarity to proteins with zinc binuclear cluster homology.; Title: similarity to hypothetical transcription activator SPAC139.03 - Schizosaccharomyces pombe; uncharacterized protein 114692 4983595 An09g00580 Aspergillus niger uncharacterized protein XP_001393382.1 112176 D 5061 CDS An09g00590 4983596 115627..116841 I 1 NT_166525.1 Catalytic activity: converts salicylate + NADH + O(2) <=> catechol + NAD(+) + H(2)O + CO(2).; Pathway: nahpthalene catabolism and phenylalanine metabolism.; Title: similarity to salicylate hydroxylase nahG -Pseudomonas putida; uncharacterized protein 116841 4983596 An09g00590 Aspergillus niger uncharacterized protein XP_001393383.1 115627 D 5061 CDS An09g00600 4983597 117324..118265 I 1 NT_166525.1 Title: similarity to hypothetical hydroxylase snoaW - Streptomyces nogalater; uncharacterized protein 118265 4983597 An09g00600 Aspergillus niger uncharacterized protein XP_001393384.1 117324 D 5061 CDS An09g00610 4983598 complement(118985..119497) I 1 NT_166525.1 Title: similarity to hypothetical protein SC6A5.32c - Streptomyces coelicolor; uncharacterized protein 119497 4983598 An09g00610 Aspergillus niger uncharacterized protein XP_059606693.1 118985 R 5061 CDS An09g00620 4983599 join(120589..121027,121087..121439,121489..121548) I 1 NT_166525.1 Function: 17 beta-hydroxysteroid dehydrogenase (17HSD) catalyzes the reversible conversion of estrone into estradiol.; Similarity: shows strong similarity to several short chain dehydrogenases, especially to estradiol 17beta-dehydrogenases (EC 1. 1. 1. 62).; Title: similarity to estradiol 17-beta-dehydrogenase HSD17B1 - Rattus norvegicus; See PMID 7925110; uncharacterized protein 121548 4983599 An09g00620 Aspergillus niger uncharacterized protein XP_001393386.3 120589 D 5061 CDS An09g00630 4983600 complement(join(123228..123391,123449..123610,123688..123700)) I 1 NT_166525.1 Title: strong similarity to hypothetical cipC -Aspergillus nidulans; uncharacterized protein 123700 4983600 An09g00630 Aspergillus niger uncharacterized protein XP_001393387.1 123228 R 5061 CDS An09g00640 4983601 join(127027..127121,127265..127901,128051..129922,129970..131898) I 1 NT_166525.1 Function: seems to be a general transcription factor.; Function: strains with the rco-1 mutant alleles were aconidial, female sterile, had reduced growth rates, and formed hyphae that coiled in a counterclockwise direction,opposite that of the wild type.; Similarity: shows only partial similarity to protein of N. crassa and several other proteins containing WD domains.; Title: similarity to transcription repressor RCO-1 -Neurospora crassa; nucleus; See PMID 8887652; uncharacterized protein 131898 4983601 An09g00640 Aspergillus niger uncharacterized protein XP_059606694.1 127027 D 5061 CDS An09g00650 4983602 join(133130..133256,133319..133700,133762..133981) I 1 NT_166525.1 Remark: a splice site was detected upstream of the START codon.; Title: similarity to hypothetical protein F9K20.18 -Arabidopsis thaliana; uncharacterized protein 133981 4983602 An09g00650 Aspergillus niger uncharacterized protein XP_001393389.1 133130 D 5061 CDS An09g00660 4983603 complement(join(134370..134442,134501..134876,134951..135027,135083..135248,135294..135618,135697..136706,136758..137007)) I 1 NT_166525.1 Function: isp4 of S. pombe is a membrane oligopeptide transporter.; Remark: isp4 of S. pombe was originally identified by subtractive screening as gene induced during the sexual differentiation process.; Similarity: the predicted A. niger protein shows strong similarity to protein isp4 of S. pombe, which belongs to the OPT subfamily of transporters specific for small oligopeptides (from the C. albicans OPT1 gene).; Title: strong similarity to protein isp4p -Schizosaccharomyces pombe; plasma membrane; See PMID 9643541; See PMID 7954893; uncharacterized protein 137007 4983603 An09g00660 Aspergillus niger uncharacterized protein XP_059606695.1 134370 R 5061 CDS An09g00670 4983604 join(139204..139284,139334..139371,139424..139449,139509..140276,140344..141056) I 1 NT_166525.1 Function: a new family of glycosylphosphatidylinositol-anchored beta(1-3)glucanosyltransferases (Gelp), recently identified and characterized in the filamentous fungus Aspergillus fumigatus, showed functional similarity to the Gas/Phr/Epd protein families, which are involved in yeast morphogenesis.; Title: strong similarity to glycosylphosphatidylinositol-anchored beta(1-3)glucanosyltransferase gel3 - Aspergillus fumigatus; plasma membrane; See PMID 9430707; uncharacterized protein 141056 4983604 An09g00670 Aspergillus niger uncharacterized protein XP_001393391.1 139204 D 5061 CDS An09g00680 4983605 complement(142135..143655) I 1 NT_166525.1 Title: strong similarity to hypothetical protein SC9B2.03 - Streptomyces coelicolor; uncharacterized protein 143655 4983605 An09g00680 Aspergillus niger uncharacterized protein XP_001393392.1 142135 R 5061 CDS An09g00690 4983606 complement(join(144173..146828,146893..147158,147257..147472)) I 1 NT_166525.1 Function: the P-type ATPase ENA1 mediates sodium and potassium effluxes in Schwanniomyces occidentalis.; Induction: the expression of ENA1 requires a high pH and the presence of Na+.; Title: strong similarity to P-type ATPase ENA1 -Schwanniomyces occidentalis; See PMID 9430707; uncharacterized protein 147472 4983606 An09g00690 Aspergillus niger uncharacterized protein XP_059606696.1 144173 R 5061 CDS An09g00700 4983607 complement(join(148000..148124,148159..148411,148450..148601,148864..148996,149148..149978)) I 1 NT_166525.1 Function: PepQ is a metalloprotease in Lactobacillus delbrueckii.; Title: similarity to X-Pro dipeptidase pepQ -Lactobacillus lactis; See PMID 9421914; uncharacterized protein 149978 4983607 An09g00700 Aspergillus niger uncharacterized protein XP_001393394.3 148000 R 5061 CDS An09g00710 84591934 join(150075..150636,150727..150987,151082..151140) I 1 NT_166525.1 Alternative name: fluoroacetate dehalogenase.; Catalytic activity: haloacetate + H(2)O = glycolate + halide.; Function: fluoroacetate dehalogenase catalyzes the dehalogenation of fluoroacetate and other haloacetates.; Remark: H-1 is encoded on the plasmid pUO1 from Moraxella sp. strain B.; Similarity: the deduced amino acid sequence of H-1 shows significant similarity to those of three hydrolases of Pseudomonas putida and a haloalkane dehalogenase of Xanthobacter autotrophicus.; Title: similarity to haloacetate dehalogenase H-1 -Moraxella sp.; See PMID 9812982; See PMID 1512562; uncharacterized protein 151140 84591934 An09g00710 Aspergillus niger uncharacterized protein XP_059606697.1 150075 D 5061 CDS An09g00720 84591935 join(151714..151759,152405..152457) I 1 NT_166525.1 Remark: questionable ORF due to the gene strukture.; Title: questionable ORF; uncharacterized protein 152457 84591935 An09g00720 Aspergillus niger uncharacterized protein XP_059606698.1 151714 D 5061 CDS An09g00730 84591936 join(153334..153429,153582..153594,153914..153958,154101..154196,154304..154325,154546..154675) I 1 NT_166525.1 hypothetical protein 154675 84591936 An09g00730 Aspergillus niger hypothetical protein XP_059606699.1 153334 D 5061 CDS An09g00770 10098210 156017..160429 I 1 NT_166525.1 Function: tto1 can transpose autonomously through reverse transcription.; Remark: tto1 uses a gene expression mechanism different from those employed by retroviruses and most retrotransposons in; Title: strong similarity to retrotransposon Tto1 -Nicotiana tabacum; See PMID 8522181; uncharacterized protein 160429 10098210 An09g00770 Aspergillus niger uncharacterized protein XP_003188790.2 156017 D 5061 CDS An09g00790 4983612 join(161883..162212,162264..162363,162418..162497,162567..162752) I 1 NT_166525.1 Catalytic activity: axe1 cleaves acetyl side chain groups from acetyl xylan.; Remark: acetyl xylan esterase axe1 of Trichoderma reesei contains an active-site serine residue and a C-terminal fungal cellulose-binding domain.; Remark: the AXE1 gene encodes 302 amino acids including a signal sequence and a putative propeptide.; Title: similarity to acetyl xylan esterase precursor axe1 - Trichoderma reesei; See PMID 8647098; uncharacterized protein 162752 4983612 An09g00790 Aspergillus niger uncharacterized protein XP_001393399.1 161883 D 5061 CDS An09g00800 4983613 complement(join(163482..164043,164094..164563,164613..164804,164858..164872,164920..165185,165243..165369)) I 1 NT_166525.1 Remark: N-terminally truncated due to contig border.; Title: similarity to zinc binuclear cluster protein sequence #31 from patent WO200224865-A2 - Unclassified organism; uncharacterized protein 165369 4983613 An09g00800 Aspergillus niger uncharacterized protein XP_059606700.1 163482 R 5061 CDS An09g00810 4983614 complement(join(166982..167460,167515..167646,167699..167869,167924..168045,168088..168269)) I 1 NT_166525.1 Similarity: shows similarity to several hypothetical oxidoreducatases.; Title: strong similarity to hypothetical zinc-binding oxidoreductase mll2116 - Mesorhizobium loti; uncharacterized protein 168269 4983614 An09g00810 Aspergillus niger uncharacterized protein XP_059605791.1 166982 R 5061 CDS An09g00820 4983615 complement(169120..169950) I 1 NT_166525.1 Catalytic activity: chloride peroxidase catalyzes the conversion of 2 RH + 2 chloride + H2O2 = 2 RCl + 2 H2O.; Similarity: shows strong similarity to several bacterial known chloride and bromide peroxidases.; Title: strong similarity to chloride peroxidase est - Pseudomonas putida; See PMID 7670178; See PMID 11342031; uncharacterized protein 169950 4983615 An09g00820 Aspergillus niger uncharacterized protein XP_001393402.1 169120 R 5061 CDS An09g00830 4983616 join(170670..170722,170782..171619,171813..171834,172101..172150) I 1 NT_166525.1 Title: strong similarity to hypothetical protein BAC55926.1 - Acinetobacter calcoaceticus; uncharacterized protein 172150 4983616 An09g00830 Aspergillus niger uncharacterized protein XP_001393403.3 170670 D 5061 CDS An09g00840 4983617 join(173071..173409,173473..173657,173898..173943,173998..174045) I 1 NT_166525.1 Title: similarity to plastic-degradation enzyme within SEQ ID NO:6 from patent WO2004038016-A1 -Aspergillus oryzae; uncharacterized protein 174045 4983617 An09g00840 Aspergillus niger uncharacterized protein XP_001393404.3 173071 D 5061 CDS An09g00850 4983618 join(174813..175425,175481..177636,177688..178385,178443..>179305) I 1 NT_166525.1 Remark: a putative sequencing error results in an frameshift.; Similarity: shows strong similarity to several ABC-type multidrug transporters of different specificities and of different species.; Title: strong similarity to ATP-binding cassette multidrug transport protein atrA - Aspergillus nidulans [putative frameshift]; plasma membrane; putative frameshift; See PMID 9180695; uncharacterized protein 179305 4983618 An09g00850 Aspergillus niger uncharacterized protein XP_059605792.1 174813 D 5061 CDS An09g00860 4983619 complement(join(179812..181065,181125..181627,181675..181700,181755..182092)) I 1 NT_166525.1 Similarity: shows similarity to several known and hypothetical transcriptional activators, the similarity is restricted to the zinc finger domain.; Title: similarity to hypothetical transcription activator CAB59617.1 - Schizosaccharomyces pombe; uncharacterized protein 182092 4983619 An09g00860 Aspergillus niger uncharacterized protein XP_059605793.1 179812 R 5061 CDS An09g00870 4983620 join(182463..182660,182715..182975,183037..183372,183423..183603,183657..184339) I 1 NT_166525.1 Similarity: shows similarity to several known and hypothetical efflux transporters of different specificities of different species.; Title: strong similarity to aflatoxin efflux pump aflT - Aspergillus parasiticus; plasma membrane; uncharacterized protein 184339 4983620 An09g00870 Aspergillus niger uncharacterized protein XP_001393407.1 182463 D 5061 CDS An09g00880 4983621 join(185198..185399,185503..186010,186055..186138,186184..186260,186312..186344,186395..186534,186581..187087,187152..187541) I 1 NT_166525.1 Catalytic activity: hydrolysis of terminal non-reducing alpha-l-arabinofuranoside residues in alpha-l-arabinosides.; Function: acts only on small linear 1,5-alpha-linked l-arabinofuranosyl oligosaccharides.; Pathway: involved in degradation of the plant cell wall polysaccharide l-arabinan.; Remark: also strong similarity to abf-A gene of A. niger patent EP506190-A.; Remark: arabinan-degrading enzymes and genes -isolated from fungi and having lower pH optima than arabinan-degrading enzymes of bacterial origin.; Remark: extra copies of abfA or abfB led to a decreased expression level of ABN A, though the repression elicited by abfB is stronger and more persistent than that effected by abfA. Multiple copies of both abf genes influence expression of the other ABF similarly, but to a far less pronounced degree than they affect ABN A synthesis. Four putative promoter elements, shared by all three arabinase genes, could be involved in coordination of L-arabinan degradation by A. niger.; Similarity: belongs to family 51 of glycosyl hydrolases.; Title: strong similarity to alpha-L-arabinofuranosidase A abfA - Aspergillus niger; See PMID 8000538; uncharacterized protein 187541 4983621 An09g00880 Aspergillus niger uncharacterized protein XP_059605794.1 185198 D 5061 CDS An09g00890 4983622 complement(187786..189528) I 1 NT_166525.1 Catalytic activity: digallate + H2O = 2 gallate.; Remark: similarity to Aspergillus oryzae tannase protein patent JP08080196-A.; Remark: tannase also hydrolyses ester links in other tannins.; Remark: tannase gene product is translated as a single polypeptide that is cleaved by post-translational modification into two tannase subunits linked by a disulfide bond(s).; Remark: tannins have a wide range of effects on various organisms - from toxic effects on animals to growth inhibition of microorganisms.; Remark: the tannase can be used for clarification in beer production.; Title: strong similarity to precursor of tannase -Aspergillus oryzae; See PMID 8917102; See PMID 10192896; See PMID 11191769; uncharacterized protein 189528 4983622 An09g00890 Aspergillus niger uncharacterized protein XP_001393409.1 187786 R 5061 CDS An09g00900 84591937 complement(join(189736..189858,189922..190113,190194..190292,190370..190416,190530..190563)) I 1 NT_166525.1 hypothetical protein 190563 84591937 An09g00900 Aspergillus niger hypothetical protein XP_059605795.1 189736 R 5061 CDS An09g00910 84591938 complement(join(191099..191296,191503..191556)) I 1 NT_166525.1 Remark: the ORF is short in length (83 amino acids) and has an unusual exon/intron structure for A. niger.; Title: questionable ORF; uncharacterized protein 191556 84591938 An09g00910 Aspergillus niger uncharacterized protein XP_059605796.1 191099 R 5061 CDS An09g00920 4983625 complement(193019..195667) I 1 NT_166525.1 Title: similarity to hypothetical protein SPAC57A7.05 - Schizosaccharomyces pombe; uncharacterized protein 195667 4983625 An09g00920 Aspergillus niger uncharacterized protein XP_001393412.3 193019 R 5061 CDS An09g00930 4983626 complement(<196563..199888) I 1 NT_166525.1 Catalytic activity: ATP + H2O = ADP + orthophosphate.; Function: this is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na & K ions across the plasma membrane. This action creates the electrochemical gradient of Na & K, providing the energy for active transport of various nutrients.; Pathway: oxidative phosphorylation.; Remark: a putative sequencing error results in an frameshift.; Remark: also strong similarity to Rat (Na,K)-ATPase alpha 1 subunit gene coding region patent WO9855603-A1.; Remark: the ATPase gene appears to be present in one or very few copies in the rat and human genomes and to be transcriptionally regulated in different rat tissues.; Similarity: belongs to the cation transport ATPases family (e1-e2 ATPases).; Title: strong similarity to Na+/K+-exchanging ATPase alpha-1 chain NKAA1 - Rattus norvegicus [putative frameshift]; putative frameshift; See PMID 2166579; See PMID 2994074; uncharacterized protein 199888 4983626 An09g00930 Aspergillus niger uncharacterized protein XP_059605797.1 196563 R 5061 CDS An09g00940 84591939 complement(join(200647..200745,200839..200979,201079..201318,201434..201445)) I 1 NT_166525.1 hypothetical protein 201445 84591939 An09g00940 Aspergillus niger hypothetical protein XP_059605798.1 200647 R 5061 CDS An09g00950 4983628 complement(join(201771..203433,203485..203615)) I 1 NT_166525.1 Catalytic activity: release of an N-terminal D-Amino acid from a Peptide, Xaa-|-Yaa-, in which Xaa is preferably D-Ala, D-Ser or D-Thr. D-Amino acid amides and methyl esters also are hydrolysed, as is Clycine amide.; Remark: strong similarity to D-aminopeptidase gene in pC138K from Achromobacter sp. SCRC C1-38 patent JP03072887-A.; Remark: the enzyme appears to be a serine peptidase rather than a thiol one. The inhibition by PCMB in the wild-type enzyme may have been caused by a formation of a mercaptide bond between Cys 60 and PCMB. Considering that D-aminopeptidase, carboxypeptidase DD (a penicillin-binding protein), and beta-lactamase have a common feature in recognizing peptides containing D-amino acid and that the former two catalyze transpeptidation reactions with substrates containing D-alanyl-D-alanine moieties.; Similarity: belongs to the D-stereospecific aminopeptidases.; Title: strong similarity to D-stereospecific aminopeptidase dap - Ochrobactrum anthropi; See PMID 2760064; See PMID 1540587; uncharacterized protein 203615 4983628 An09g00950 Aspergillus niger uncharacterized protein XP_001393415.3 201771 R 5061 CDS An09g00960 84591940 complement(join(203924..204280,204332..204541)) I 1 NT_166525.1 putative sequencing error; hypothetical protein 204541 84591940 An09g00960 Aspergillus niger hypothetical protein XP_059605799.1 203924 R 5061 CDS An09g00980 4983630 complement(205241..209653) I 1 NT_166525.1 Remark: Tto1 from Nicotiana tabacum can transpose autonomously through reverse transcription and the host factors required for transposition are conserved among monocots (class Magnoliopsida; rice) and dicots (class Liliopsida; tobacco), which diverged approximately 200 million years ago.; Title: strong similarity to retrotransposon Tto1 -Nicotiana tabacum; See PMID 8624443; uncharacterized protein 209653 4983630 An09g00980 Aspergillus niger uncharacterized protein XP_001393417.1 205241 R 5061 CDS An09g01010 4983631 join(210554..210983,211062..211147,211210..211404) I 1 NT_166525.1 Catalytic activity: deacetylation of xylans and xylo-oligosaccharides.; Remark: the axe1 from T. reesei carries at its C-terminus a cellulose binding domain of fungal type, which is separated from the catalytic domain by a region rich in serine, glycine, threonine and proline. The binding domain can be separated from the catalytic domain by limited proteolysis without affecting the activity of the enzyme towards acetylated xylan, but abolishing its capability to bind cellulose.; Title: similarity to acetyl xylan esterase precursor axe1 - Trichoderma reesei; See PMID 8647098; uncharacterized protein 211404 4983631 An09g01010 Aspergillus niger uncharacterized protein XP_001393418.1 210554 D 5061 CDS An09g01020 4983632 complement(join(211563..211741,211791..212220,212356..213189,213249..213518)) I 1 NT_166525.1 Catalytic activity: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3.; Pathway: arginine and proline metabolism; phenylalanine metabolism; tryptophan metabolism; cyanoamino acid metabolism; styrene degradation.; Remark: gene disruption experiments demonstrate that the resulting mutants show significantly reduced growth on acetamide-containing medium, indicating that the A. oryzae amdS gene encodes a functional acetamidase that is required for acetamide utilization.; Similarity: belongs to the amidase family.; Title: strong similarity to acetamidase amdS -Aspergillus oryzae; See PMID 1840550; uncharacterized protein 213518 4983632 An09g01020 Aspergillus niger uncharacterized protein XP_059605800.1 211563 R 5061 CDS An09g01030 4983633 214291..216009 I 1 NT_166525.1 Catalytic activity: a 2-oxo acid = an aldehyde + CO2; pyruvate = acetaldehyde + CO2.; Pathway: glycolysis / gluconeogenesis.; Remark: although A. parasiticus has an obligate growth requirement for oxygen, it produced ethanol in shake flask cultures indicating a response to anoxic conditions mediated by pyruvate decarboxylase.; Similarity: whith other enzymes which requires TTP; Title: strong similarity to pyruvate decarboxylase dcpY - Aspergillus parasiticus; See PMID 8181725; uncharacterized protein 216009 4983633 An09g01030 Aspergillus niger uncharacterized protein XP_001393420.1 214291 D 5061 CDS An09g01040 4983634 complement(join(216109..216148,216262..216379,216457..216627,216692..216908,216959..217055,217197..217519,217589..217767,217864..217990)) I 1 NT_166525.1 Remark: Kr2 transcripts of mouse can be detected in all the major structures of the developing nervous system during embryogenesis. The data are consistent with the hypothesis that mKr2 is a regulatory factor required for the differentiation and/or phenotypic maintenance of neurons.; Title: similarity to developmental control protein Kr2 - Mus musculus; See PMID 3409867; See PMID 3815523; uncharacterized protein 217990 4983634 An09g01040 Aspergillus niger uncharacterized protein XP_059605801.1 216109 R 5061 CDS An09g01050 4983635 complement(218661..219857) I 1 NT_166525.1 Catalytic activity: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycerol-3-phosphocholine + acetate.; Pathway: Glycerolipid metabolism.; Remark: purified PAF-acetylhydrolase, which converts PAF to an inactive metabolite, lysoPAF, from peritoneal fluid of guinea pigs subjected to experimental endotoxin shock and found that this purified enzyme had similar biochemical properties to the plasma enzyme.; Similarity: belongs to the family of hydrolases.; Title: similarity to platelet-activating factor-acetylhydrolase - Cavia porcellus; See PMID 8947850; uncharacterized protein 219857 4983635 An09g01050 Aspergillus niger uncharacterized protein XP_001393422.3 218661 R 5061 CDS An09g01060 84591941 complement(join(220356..220434,220500..220607,220785..220867)) I 1 NT_166525.1 hypothetical protein 220867 84591941 An09g01060 Aspergillus niger hypothetical protein XP_059605802.1 220356 R 5061 CDS An09g01070 4983637 complement(221296..222744) I 1 NT_166525.1 Remark: strong similarity to patent WO0100842-A/419 from Corynebacterium glutamicum.; Remark: the sequence shows similarity to several nitrilotriacetate monooxygenases.; Title: strong similarity to protein from patent WO0100842-A - Corynebacterium glutamicum; uncharacterized protein 222744 4983637 An09g01070 Aspergillus niger uncharacterized protein XP_001393424.1 221296 R 5061 CDS An09g01080 4983638 complement(join(223407..223942,223990..224455,224577..224831)) I 1 NT_166525.1 Remark: LovC interacts with LNKS and is necessary for the correct processing of the growing polyketide chain and production of dihydromonacolin L.; Remark: putative part of the lovastatin biosynthesis gene cluster as seen in Aspergillus terreus.; Title: similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994; uncharacterized protein 224831 4983638 An09g01080 Aspergillus niger uncharacterized protein XP_059605803.1 223407 R 5061 CDS An09g01090 4983639 join(225797..226102,226147..226869,226914..227516) I 1 NT_166525.1 Function: MUP3 is a very low affinity methionine permease.; Remark: alternative name is YHL036w.; Remark: in mup1 mup3 double null mutants the methionine uptake is strongly inhibited by L-ethionine,L-leucine, L-histidine, L-threonine and L-phenylalanine.; Title: strong similarity to methionine uptake protein Mup3 - Saccharomyces cerevisiae; See PMID 8893857; uncharacterized protein 227516 4983639 An09g01090 Aspergillus niger uncharacterized protein XP_059605804.1 225797 D 5061 CDS An09g01100 4983640 join(227800..228155,228213..228655,228764..228834) I 1 NT_166525.1 Complex: S. lactamdurans 7 alpha-cephem-methoxylase two-protein component system formed by cmcI and cmcJ.; Function: S. lactamdurans cmcJ forms part of the 7 alpha-cephem-methoxylase which converts the antibiotic cephalosporin C to 7-methoxycephalosporin C.; Title: strong similarity to 7alpha-cephem-methoxylase subunit cmcJ - Streptomyces lactamdurans; See PMID 7721717; uncharacterized protein 228834 4983640 An09g01100 Aspergillus niger uncharacterized protein XP_001393427.3 227800 D 5061 CDS An09g01110 4983641 join(229345..230096,230153..230291,230368..230492,230574..230670,230719..230877) I 1 NT_166525.1 Similarity: the predicted A. niger protein shows weak similarity to a human cation transporter and contains a weak sugar transporter motif.; Title: strong similarity to hypothetical protein SPAC922.05c - Schizosaccharomyces pombe; uncharacterized protein 230877 4983641 An09g01110 Aspergillus niger uncharacterized protein XP_059605805.1 229345 D 5061 CDS An09g01120 4983642 complement(<230962..232954) I 1 NT_166525.1 Remark: putative sequencing errors results in premature stop codons; Remark: the systematic name for S. cerevisiae Prm10 is YJL108c.; Title: strong similarity to cDNA of pheromone-regulated Prm10 - Saccharomyces cerevisiae [putative frameshift]; putative frameshift; See PMID 11062271; uncharacterized protein 232954 4983642 An09g01120 Aspergillus niger uncharacterized protein XP_059605806.1 230962 R 5061 CDS An09g01125 4983643 complement(234083..234547) I 1 NT_166525.1 hypothetical protein 234547 4983643 An09g01125 Aspergillus niger hypothetical protein XP_001393430.1 234083 R 5061 CDS An09g01130 4983644 complement(234956..235945) I 1 NT_166525.1 Title: similarity to kprotein fragment SEQ ID NO:4711 from patent EP1108790-A2 - Corynebacterium glutamicum; uncharacterized protein 235945 4983644 An09g01130 Aspergillus niger uncharacterized protein XP_001393431.1 234956 R 5061 CDS An09g01140 4983645 complement(join(236259..236316,236367..236582,236643..236704,236783..237114,237177..237270)) I 1 NT_166525.1 Title: similarity to glucanase ZmGnsN3 from patent WO200073470-A2 - Zea mays; uncharacterized protein 237270 4983645 An09g01140 Aspergillus niger uncharacterized protein XP_001393432.1 236259 R 5061 CDS An09g01150 4983646 complement(join(237384..237797,237897..238169,238227..238601,238656..238866,238918..239015)) I 1 NT_166525.1 Function: mouse WOX1 is an enhancer of tumor necrosis factor (TNF) mediated apoptosis.; Function: upon TNF induced activation mouse WOX1 confers significant down-regulation of the apoptosis inhibitors Bcl-2 and Bcl-x(L) (>85%) and up-regulation of the pro-apoptotic p53 (approximately 200%) via its C-terminal alcohol dehydrogenase (ADH) domain.; Localization: mouse WOX1 is mainly located in the mitochondria and shows TNF-mediated WOX1 nuclear translocation.; Title: strong similarity to mitochondrial apoptogenic protein WOX1 - Mus musculus; localisation:mitochondrion; See PMID 11058590; uncharacterized protein 239015 4983646 An09g01150 Aspergillus niger uncharacterized protein XP_001393433.3 237384 R 5061 CDS An09g01160 4983647 join(239647..239815,239875..240381,240452..240678) I 1 NT_166525.1 Title: strong similarity to hypothetical protein SPBC409.17c - Schizosaccharomyces pombe; uncharacterized protein 240678 4983647 An09g01160 Aspergillus niger uncharacterized protein XP_001393434.1 239647 D 5061 CDS An09g01170 4983648 complement(join(240857..241132,241169..241570,241619..241675,241736..242050)) I 1 NT_166525.1 Function: rice ACC oxidase is involved in the formation of the ethylene precursor 1-aminocyclopropane-1-carboxylic acid (ACC) from S-adenosylmethionine (AdoMet).; Remark: information concerning rice ACC oxidase is not available via PubMed and has been published by Cohen,E.; Kende, H. : In vivo 1-aminocyclopropane-1-carboxylate synthase activity in internodes of deepwater rice; Plant Physiol., 84; 282-286 (1987).; Title: similarity to 1-aminocyclopropane-1-carboxylate oxidase - Oryza sativa; See PMID 11031228; uncharacterized protein 242050 4983648 An09g01170 Aspergillus niger uncharacterized protein XP_059605807.1 240857 R 5061 CDS An09g01180 4983649 join(243875..244460,244513..245039) I 1 NT_166525.1 Title: weak similarity to hypothetical protein encoded by An11g08730 - Aspergillus niger; uncharacterized protein 245039 4983649 An09g01180 Aspergillus niger uncharacterized protein XP_001393436.1 243875 D 5061 CDS An09g01190 4983650 join(247768..248034,248085..248561,248621..248706,248758..248893) I 1 NT_166525.1 Catalytic activity: Arabinan endo-1,5-alpha-L-arabinosidases catalyse the endohydrolysis of 1,5-alpha-L-arabinofuranosidic linkages in 1,5-arabinans.; Function: A. niger abnA is involved in carbohydrate catabolism.; Gene-ID: abnA; See PMID 7764386; endo 1,5-alpha-arabinanase abnA-Aspergillus niger 248893 abnA 4983650 abnA Aspergillus niger endo 1,5-alpha-arabinanase abnA-Aspergillus niger XP_001393437.1 247768 D 5061 CDS An09g01200 4983651 join(250157..250242,250317..250353,250414..252066) I 1 NT_166525.1 Remark: LYS14 of S. cerevisiae has a systematic name of YDR034C.; Similarity: similarity is between the N-terminal regions of the predicted A. niger protein and S. cerevisiae Lys14.; Similarity: the predicted A. niger protein contains a N-terminalfungal Gal4-type Zn(2)-Cys(6) DNA-binding domain.; Title: weak similarity to transcription activator of lysine pathway Lys14 - Saccharomyces cerevisiae; nucleus; See PMID 7935367; uncharacterized protein 252066 4983651 An09g01200 Aspergillus niger uncharacterized protein XP_059605808.1 250157 D 5061 CDS An09g01210 4983652 join(253120..253557,253619..253729,253782..253821,253880..254148) I 1 NT_166525.1 Function: E. chrysanthemi kduD is involved in pectin catabolism.; Title: strong similarity to 2-keto-3-deoxygluconate oxidoreductase kduD - Erwinia chrysanthemi; See PMID 3949717; uncharacterized protein 254148 4983652 An09g01210 Aspergillus niger uncharacterized protein XP_001393439.1 253120 D 5061 CDS An09g01220 4983653 join(254357..254457,254621..254716,254772..255015,255185..255496,255548..257065) I 1 NT_166525.1 Similarity: the ORF encoded protein shows also strong similarity to EST EMBLEST:BE760598 an_1942 from Aspergillus niger; Similarity: the predicted A. niger protein shows similarity to several hypothetical ATP/GTP binding proteins.; Title: similarity to hypothetical ATP/GTP-binding protein SCC61A.02 - Streptomyces coelicolor; uncharacterized protein 257065 4983653 An09g01220 Aspergillus niger uncharacterized protein XP_059605809.1 254357 D 5061 CDS An09g01230 4983654 complement(join(257159..257189,257260..257374,257467..257581)) I 1 NT_166525.1 Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 257581 4983654 An09g01230 Aspergillus niger uncharacterized protein XP_001393441.1 257159 R 5061 CDS An09g01240 4983655 258697..260613 I 1 NT_166525.1 Function: P. notatum phospholipase B hydrolyzes both the acyl ester bonds of diacylphospholipids (diacyl-hydrolase) and the acyl ester bond of monoacylphospholipids or lysophospholipids.; Remark: A. niger lysophospholipase has been patented as Sequence 3 from Patent WO0127251.; Remark: P. notatum phospholipase B is a glycoprotein.; Title: strong similarity to phospholipase B -Penicillium notatum; See PMID 5402; uncharacterized protein 260613 4983655 An09g01240 Aspergillus niger uncharacterized protein XP_001393442.1 258697 D 5061 CDS An09g01250 84591942 complement(join(260985..261735,261923..262042,262246..262331,262518..262562)) I 1 NT_166525.1 Title: weak similarity to hypothetical protein encoded by An11g02890 - Aspergillus niger; uncharacterized protein 262562 84591942 An09g01250 Aspergillus niger uncharacterized protein XP_059605810.1 260985 R 5061 CDS An09g01260 4983657 complement(262828..264024) I 1 NT_166525.1 Remark: aa sequence and possible function of human OXRD-1 where predicted from isolated Incyte clone 266711CD1.; Title: similarity to oxidoreductase OXRD-1 from patent WO200071679-A2 - Homo sapiens; uncharacterized protein 264024 4983657 An09g01260 Aspergillus niger uncharacterized protein XP_001393444.1 262828 R 5061 CDS An09g01270 4983658 join(265657..266118,266179..266851,266939..267204,267317..267460) I 1 NT_166525.1 Catalytic activity: RH + Reduced flavoprotein + O2 = ROH + Oxidized flavoprotein.; Function: YlALK1 functions to assimilate n-decane and longer molecules in Yarrowia lipolytica.; Induction: the expression of the P450 gene YlALK1 was induced by n-tetradecane and repressed by glycerol in Yarrowia lipolytica.; Remark: disruption of Yarrowia lipolytica gene ALK1 results in decreased n-decane assimilation.; Title: strong similarity to n-alkane inducible cytochrome P450 protein ALK1 - Yarrowia lipolytica; See PMID 3892551; See PMID 9848230; See PMID 10953079; uncharacterized protein 267460 4983658 An09g01270 Aspergillus niger uncharacterized protein XP_001393445.3 265657 D 5061 CDS An09g01280 84591943 join(267964..268296,268803..269015) I 1 NT_166525.1 Remark: the predicted ORF contains an suboptimal long intron.; Title: questionable ORF; uncharacterized protein 269015 84591943 An09g01280 Aspergillus niger uncharacterized protein XP_059605811.1 267964 D 5061 CDS An09g01290 4983660 join(269286..269818,269875..270388,270549..271113,271164..271613,271690..274007,274055..274151,274209..274234,274301..275164,275218..275499,275560..275634,275698..276038,276098..276101,276214..276570,276630..277481,277525..277611) I 1 NT_166525.1 Function: G. fujikuroi FUM5 is a polyketide synthase required for fumonisin-toxin biosynthesis.; Title: strong similarity to polyketide synthase FUM5 - Gibberella moniliformis; See PMID 10413619; See PMID 11238987; uncharacterized protein 277611 4983660 An09g01290 Aspergillus niger uncharacterized protein XP_059605812.1 269286 D 5061 CDS An09g01300 4983661 complement(join(277829..278395,278458..278607,278669..279021,279196..279315,279376..279439)) I 1 NT_166525.1 Title: weak similarity to protein fragment SEQ ID NO:2141 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 279439 4983661 An09g01300 Aspergillus niger uncharacterized protein XP_059605813.1 277829 R 5061 CDS An09g01310 4983662 complement(join(280253..281948,282005..282579)) I 1 NT_166525.1 hypothetical protein 282579 4983662 An09g01310 Aspergillus niger hypothetical protein XP_001393449.1 280253 R 5061 CDS An09g01320 4983663 join(283174..283236,283298..283686,283738..283942,284004..285119) I 1 NT_166525.1 Function: A. oryzea mreA is an isoamyl alcohol oxidase; Title: strong similarity to isoamyl alcohol oxidase mreA - Aspergillus oryzae; uncharacterized protein 285119 4983663 An09g01320 Aspergillus niger uncharacterized protein XP_001393450.1 283174 D 5061 CDS An09g01330 4983664 complement(join(285485..285513,285557..285627,285681..285877,285928..287173,287238..287704,287772..287993)) I 1 NT_166525.1 Function: S. cerevisiae ERG7 is responsible for the complex cyclization/rearrangement step in sterol biosynthesis.; Title: strong similarity to lanosterol synthase Erg7 - Saccharomyces cerevisiae; See PMID 7791529; See PMID 8134375; uncharacterized protein 287993 4983664 An09g01330 Aspergillus niger uncharacterized protein XP_001393451.3 285485 R 5061 CDS An09g01340 4983665 join(288737..289047,289118..289658,289748..290053,290107..290254,290286..290334,290384..290414) I 1 NT_166525.1 Catalytic activity: leukotriene-B4 20-monooxygenases convert 6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10, 14-tetraenoate + NADPH + O(2) to (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14 -tetraenoate + NADP(+) + H(2)O.; Function: human Cyp4F2 is involved in metabolisation of leukotriene B(4) (LTB(4)) to a less potent proinflammatory eicosanoid, 20-OH-LTB(4).; Localization: human Cyp4F2 was isolated from microsomes.; Similarity: similarity is between the C-terminal regions of the predicted A. niger protein and human Cyp4F2.; Title: similarity to leukotriene B(4) omega-hydroxylase cytochrome P450 4F2 CYP4F2 - Homo sapiens; See PMID 10833273; uncharacterized protein 290414 4983665 An09g01340 Aspergillus niger uncharacterized protein XP_059605814.1 288737 D 5061 CDS An09g01350 84591944 join(290872..290919,291249..291434) I 1 NT_166525.1 Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 291434 84591944 An09g01350 Aspergillus niger uncharacterized protein XP_059605815.1 290872 D 5061 CDS An09g01370 4983668 complement(join(291873..292535,292589..292726,292822..293156,293217..293340,293403..293594)) I 1 NT_166525.1 Catalytic activity: lignostilbene alpha beta-dioxygenases convert 1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O(2) to 2 vanillin.; Complex: P. paucimobilis LSD forms a heterodimer.; Function: P. paucimobilis LSD is responsible for the degradation of a diarylpropane-type structure in lignin-derived stilbenes.; Title: strong similarity to lignostilbene-alpha,beta-dioxygenase LSD - Pseudomonas paucimobilis; See PMID 7763879; uncharacterized protein 293594 4983668 An09g01370 Aspergillus niger uncharacterized protein XP_059605816.1 291873 R 5061 CDS An09g01380 4983669 join(294162..294466,294580..294933,295001..295047,295104..296056) I 1 NT_166525.1 Catalytic activity: vanillyl-alchool oxidase of P. simplicissimum and other organisms converts a wide range of 4-hydroxybenzyl alcohols and 4-hydroxybenzylamines into the corresponding aldehydes.; Complex: vanillyl-alchool oxidase is a homooctamer.; Localization: in P. simplicissimum the enzyme is located both in the cytoplasm and in peroxisomes.; Title: strong similarity to vanillyl-alcohol oxidase vaoA - Penicillium simplicissimum; See PMID 8529652; See PMID 9013853; See PMID 9141139; See PMID 9261083; See PMID 1396672; uncharacterized protein 296056 4983669 An09g01380 Aspergillus niger uncharacterized protein XP_001393455.1 294162 D 5061 CDS An09g01390 84591945 complement(join(296330..296715,296768..297237,297285..297434,297507..298224,298281..298329)) I 1 NT_166525.1 Similarity: although some of the proteins showing weak similarity to the predicted ORF are annotated as transcription factor due to the presence of a Zn-2Cys-6 binuclear cluster, the predicted protein itself does not contain such domain.; Title: similarity to transcriptional activator Mut3 - Pichia angusta; See PMID 11126774; uncharacterized protein 298329 84591945 An09g01390 Aspergillus niger uncharacterized protein XP_059605817.1 296330 R 5061 CDS An09g01400 84591946 join(298866..298949,299036..299143,299309..299393,299463..299698) I 1 NT_166525.1 hypothetical protein 299698 84591946 An09g01400 Aspergillus niger hypothetical protein XP_059605818.1 298866 D 5061 CDS An09g01410 84591947 complement(join(<299816..300713,300769..301118,301213..301414)) I 1 NT_166525.1 Function: N. haematococca detoxify the antibioticum pisatin utilizing the cytochrome P450 monooxygenase PADT9.; Remark: putative frameshift due to possible sequencing error at position 55431.; Similarity: N. haematococca PDAT9 has been assigned to a new cytochrome P450 family, CYP57.; Title: strong similarity to cytochrome P450 pisatin demethylase PDAT9 - Nectria haematococca [putative frameshift]; putative frameshift; See PMID 9501474; See PMID 9683653; uncharacterized protein 301414 84591947 An09g01410 Aspergillus niger uncharacterized protein XP_059605819.1 299816 R 5061 CDS An09g01420 84591948 join(301627..301787,301927..302278) I 1 NT_166525.1 Similarity: the C-terminal half of the predicted protein shows similarity to the N-terminal half of CAC3321 of C. acetobutylicum.; Title: similarity to hypothetical protein homolog of yveG CAC3321 - Clostridium acetobutylicum; uncharacterized protein 302278 84591948 An09g01420 Aspergillus niger uncharacterized protein XP_059605820.1 301627 D 5061 CDS An09g01430 4983674 complement(join(303246..304144,304194..304448,304511..304538)) I 1 NT_166525.1 Induction: the cDNA possibly encoding the AWI 31 protein is induced upon tissue wounding in A. thaliana.; Title: similarity to hypothetical induced upon wounding stress protein AWI 31 - Arabidopsis thaliana; See PMID 9085278; uncharacterized protein 304538 4983674 An09g01430 Aspergillus niger uncharacterized protein XP_001393460.1 303246 R 5061 CDS An09g01440 4983675 join(305391..305601,305667..306280,306335..306678,306753..307056) I 1 NT_166525.1 Function: MAK1 the fungal pathogen N. haematococca encodes an FAD-dependent mono-oxygenase, known to specifically hydroxylate the phytoalexins medicarpin and maackiain, converting them to less fungitoxic derivatives.; Remark: medicarpin and maackiain are antifungal pterocarpan phytoalexins produced by many legumes, and are thought to be important components of the defense response of these legumes to certain fungal pathogens.; Similarity: the predicted ORF shows similarity to different known and putative monooxygenases and in particular to MAK1 of N. haematococca.; Title: strong similarity to maackiain detoxification protein MAK1 - Nectria haematococca; See PMID 8709942; See PMID 11485199; uncharacterized protein 307056 4983675 An09g01440 Aspergillus niger uncharacterized protein XP_001393461.1 305391 D 5061 CDS An09g01450 84591949 complement(join(308609..308861,308894..308901)) I 1 NT_166525.1 Similarity: the predicted protein is very similar to the C-terminal half of CAC2826 of C. acetobutylicum.; Title: strong similarity to hypothetical intracellular protease/amidase related enzyme of the ThiJ family CAC2826 - Clostridium acetobutylicum; uncharacterized protein 308901 84591949 An09g01450 Aspergillus niger uncharacterized protein XP_059605821.1 308609 R 5061 CDS An09g01460 84591950 complement(join(309500..309987,310053..310449)) I 1 NT_166525.1 Title: strong similarity to hypothetical protein encoded by An03g03400 - Aspergillus niger; uncharacterized protein 310449 84591950 An09g01460 Aspergillus niger uncharacterized protein XP_059605822.1 309500 R 5061 CDS An09g01470 84591951 join(310904..311055,311227..311298,311359..311446) I 1 NT_166525.1 hypothetical protein 311446 84591951 An09g01470 Aspergillus niger hypothetical protein XP_059605823.1 310904 D 5061 CDS An09g01480 4983679 join(311564..311992,312062..312567,312628..312985) I 1 NT_166525.1 Title: strong similarity to hypothetical protein encoded by An03g03390 - Aspergillus niger; uncharacterized protein 312985 4983679 An09g01480 Aspergillus niger uncharacterized protein XP_001393465.1 311564 D 5061 CDS An09g01490 4983680 complement(314660..315838) I 1 NT_166525.1 Similarity: the ORF encoded protein shows also weak similarity to hypothetical protein SPBC3H7. 05c from Schizosaccharomyces pombe; Similarity: the similarity to SPBC3H7. 05c of S. pombe is due to a very short, but well conserved, amino acid stretch.; Title: strong similarity to hypothetical protein EAA74627.1 - Gibberella zeae; uncharacterized protein 315838 4983680 An09g01490 Aspergillus niger uncharacterized protein XP_059605824.1 314660 R 5061 CDS An09g01500 4983681 join(318213..318505,318579..319209) I 1 NT_166525.1 Similarity: the predicted protein shows weaker similarity also to some proteins annotated as spliceosomal components.; Title: weak similarity to hypothetical protein B2O8.260 - Neurospora crassa; uncharacterized protein 319209 4983681 An09g01500 Aspergillus niger uncharacterized protein XP_001393467.1 318213 D 5061 CDS An09g01510 4983682 complement(join(320620..321159,321275..321293,321655..321842)) I 1 NT_166525.1 hypothetical protein 321842 4983682 An09g01510 Aspergillus niger hypothetical protein XP_059605825.1 320620 R 5061 CDS An09g01520 4983683 complement(join(322519..322656,322722..323726)) I 1 NT_166525.1 Remark: the F-box domain is present in numerous proteins and serves as a link between a target protein and a ubiquitin-conjugating enzyme.; Similarity: the similarity to human FBP-7 is due to the presence of an F-box domain.; Title: weak similarity to F-box protein FBP-7 from patent WO200012679-A1 - Homo sapiens; uncharacterized protein 323726 4983683 An09g01520 Aspergillus niger uncharacterized protein XP_001393469.3 322519 R 5061 CDS An09g01530 84591952 join(324946..324978,325194..325283,325336..325497,325568..325798) I 1 NT_166525.1 Function: there are no structural features, in the predicted protein, that can support a role as protease.; Title: weak similarity to precursor of IgA-specific metalloendopeptidase - Neisseria gonorrhoeae; See PMID 3027577; uncharacterized protein 325798 84591952 An09g01530 Aspergillus niger uncharacterized protein XP_059605826.1 324946 D 5061 CDS An09g01540 4983685 complement(join(325994..327328,327365..328088,328133..328285,328335..328420)) I 1 NT_166525.1 Similarity: the similarity to PPR1 of S. cerevisiae and other transcription factors is due to the presence of an N-terminal Zn-2Cys-6 binuclear cluster DNA-binding domain.; Title: weak similarity to transcription activator Ppr1 - Saccharomyces cerevisiae; See PMID 8668194; See PMID 9290251; uncharacterized protein 328420 4983685 An09g01540 Aspergillus niger uncharacterized protein XP_059605827.1 325994 R 5061 CDS An09g01550 4983686 complement(join(328898..329033,329083..330053,330101..330677,330733..331064)) I 1 NT_166525.1 Catalytic activity: RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).; Cofactor: copper and topaquinone.; Complex: AO-I of A. niger forms homodimers.; Gene-ID: AO-I; Induction: AO-I from A. niger is induced by N-butylamin.; Localization: AO-I is located in the cell wall and probably serves primarily as a detoxifying agent,preventing amines from entering and damaging the cell.; Remark: protein sequence PIR:S71320 is wrong, and it was updated by the same authors with sequences TREMBL:AF362473_1 and TREMBL:ANU31869_1.; Similarity: AO-I from A. niger belongs to a group of enzymes including those oxidizing primary monoamines,diamines and histamine.; Similarity: AO-I from A. niger belongs to the copper/topaquinone oxidase family.; Similarity: in A. niger, a similar protein, called AO-II, is probably encoded by the same gene; it might represent a misfolded form of AO-I.; Similarity: two other ORFs show strong similarity to AO-I of A. niger.; cell wall; See PMID 7957232; See PMID 8598539; See PMID 8620882; See PMID 8679675; See PMID 8872745; copper amine oxidase AO-I-Aspergillus niger 331064 AO-I 4983686 AO-I Aspergillus niger copper amine oxidase AO-I-Aspergillus niger XP_001393472.1 328898 R 5061 CDS An09g01560 4983687 complement(join(331457..331490,331609..331922,331976..333058)) I 1 NT_166525.1 Similarity: the predicted protein shows a much stronger similarity to hypothetical protein ORF1 of clone frb110/goh of Ustilago maydis.; Similarity: the similarity to b3Gal-T8 of H. sapiens is due to a very short, but very conserved, amino acid stretch.; Title: weak similarity to beta-1,3-galactosyltransferase b3Gal-T8 - Homo sapiens; See PMID 10580128; uncharacterized protein 333058 4983687 An09g01560 Aspergillus niger uncharacterized protein XP_001393473.3 331457 R 5061 CDS An09g01570 84591953 complement(join(333672..333823,334086..334215,334470..334529)) I 1 NT_166525.1 hypothetical protein 334529 84591953 An09g01570 Aspergillus niger hypothetical protein XP_059605828.1 333672 R 5061 CDS An09g01580 4983689 complement(join(334959..335439,335504..335848,335905..336044,336098..336717,336782..336873,336982..337010)) I 1 NT_166525.1 Similarity: the predicted protein does not contain a RING domain.; Similarity: the predicted protein shows stronger similarity to the A. fumigatus protein CAD29609. 1.; Title: weak similarity to RING finger protein rngB -Dictyostelium discoideum; See PMID 8647262; uncharacterized protein 337010 4983689 An09g01580 Aspergillus niger uncharacterized protein XP_059605829.1 334959 R 5061 CDS An09g01590 84591954 complement(join(337145..337252,337370..337434,337503..337619,337808..337971,338081..338100)) I 1 NT_166525.1 hypothetical protein 338100 84591954 An09g01590 Aspergillus niger hypothetical protein XP_059605830.1 337145 R 5061 CDS An09g01600 84591955 join(338505..338597,338864..339013,339119..339199) I 1 NT_166525.1 Similarity: the similarity to NMA1338 of N. meningitidis is due to a very short, but very conserved,amino acid stretch.; Title: weak similarity to hypothetical oxidoreductase NMA1338 - Neisseria meningitidis; uncharacterized protein 339199 84591955 An09g01600 Aspergillus niger uncharacterized protein XP_059605831.1 338505 D 5061 CDS An09g01610 84591956 join(339313..339418,339556..339666,339767..339952,340505..340563) I 1 NT_166525.1 hypothetical protein 340563 84591956 An09g01610 Aspergillus niger hypothetical protein XP_059605832.1 339313 D 5061 CDS An09g01620 4983693 complement(join(340748..340764,340817..340878,341019..341097,341145..341855,342129..342965,343043..343079)) I 1 NT_166525.1 Title: weak similarity to hypothetical protein encoded by An07g08820 - Aspergillus niger; uncharacterized protein 343079 4983693 An09g01620 Aspergillus niger uncharacterized protein XP_059605833.1 340748 R 5061 CDS An09g01630 4983694 join(343613..343945,343995..344942) I 1 NT_166525.1 Remark: the patent describes new secreted and transmembrane polypeptides and their polynucleotides,useful for treating blood coagulation disorders, cancers and cellular adhesion disorders.; Title: similarity to protein PRO706 from patent WO9946281-A2 - Homo sapiens; uncharacterized protein 344942 4983694 An09g01630 Aspergillus niger uncharacterized protein XP_001393480.3 343613 D 5061 CDS An09g01640 84591957 complement(join(345201..345304,345363..345443,345526..345604)) I 1 NT_166525.1 Similarity: other two A. niger ESTs, comprising part of the last exon and the 3'-UTR, confirm the expression of this ORF.; Similarity: the predicted ORF corresponds to A. niger EST EMBLEST:BE759892, comprising 5'-UTR, all the three exons and the 3'-UTR.; Title: strong similarity to EST an_2830 -Aspergillus niger; uncharacterized protein 345604 84591957 An09g01640 Aspergillus niger uncharacterized protein XP_059605834.1 345201 R 5061 CDS An09g01650 4983696 join(346438..346594,346644..346738,346800..347123,347180..347332,347378..347739,347799..348354) I 1 NT_166525.1 Similarity: in particular ORF10 of A. terreus lovastatin gene cluster and toxA of Cochliobolus carbonum might be involved in the efflux, respectively, of lovastatin A or HC-toxin produced by the two organisms.; Similarity: the predicted protein shows similarity to many hypothetical permeases of the major facilitator superfamily, mainly involved in multidrug transport.; Title: similarity to hypothetical membrane protein YMR088c - Saccharomyces cerevisiae; See PMID 8704997; See PMID 10334994; uncharacterized protein 348354 4983696 An09g01650 Aspergillus niger uncharacterized protein XP_001393482.1 346438 D 5061 CDS An09g01660 4983697 join(348754..348772,348829..348998) I 1 NT_166525.1 Title: strong similarity to hypothetical protein SPBC32F12.15 - Schizosaccharomyces pombe; uncharacterized protein 348998 4983697 An09g01660 Aspergillus niger uncharacterized protein XP_001393483.3 348754 D 5061 CDS An09g01670 84591958 349528..350382 I 1 NT_166525.1 Localization: HSP30 of N. crassa reversibly associates with mitochondria during heat shock.; Title: weak similarity to heat shock protein 30 hsp30 - Neurospora crassa; See PMID 2144284; uncharacterized protein 350382 84591958 An09g01670 Aspergillus niger uncharacterized protein XP_059605835.1 349528 D 5061 CDS An09g01680 4983699 complement(join(350800..351523,351582..351871)) I 1 NT_166525.1 Function: RTA1 of S. cerevisiae is involved in 7-aminocholesterol resistance.; Similarity: the predicted protein shows much stronger similarity to hypothetical proteins with unknown function.; Title: similarity to 7-aminocholesterol resistance protein Rta1 - Saccharomyces cerevisiae; See PMID 8660468; uncharacterized protein 351871 4983699 An09g01680 Aspergillus niger uncharacterized protein XP_001393485.1 350800 R 5061 CDS An09g01690 4983700 complement(join(352774..352907,352951..353061,353131..353200,353293..353344,353477..356868,356915..360582,360718..361435,361496..361692,361746..362013)) I 1 NT_166525.1 Function: in C. carbonum, a fungal plant pathogen,HTS1 synthesizes HC-toxin, a cyclic tetrapeptide conferring the fungus exceptional virulence on certain genotypes of maize.; Similarity: NRPSs have a modular architecture, where a module is the catalytic unit that incorporate a specific amino acid into the growing chain; each module is composed at least by three different domains: an adenylation domain, a 4'-phosphopantetheine attachment domain (peptidyl carrier) and a condensation domain.; Similarity: in the predicted ORF at least two modules are present, and are characterized by the three described domains.; Similarity: the predicted ORF shows strong similarity to several non-ribosomal peptide synthetases (NRPSs), a class of multifunctional enzymes required for the biosynthesis of a variety of biologically relevant peptide compounds.; Title: strong similarity to HC-toxin synthase HTS1 -Cochliobolus carbonum; See PMID 9756477; See PMID 10811885; See PMID 1281482; uncharacterized protein 362013 4983700 An09g01690 Aspergillus niger uncharacterized protein XP_059605836.1 352774 R 5061 CDS An09g01700 4983701 join(362941..363150,363212..363734,363788..364023,364075..364354,364410..364643,364697..365430,365492..365654,365710..366045,366092..366194,366262..366336,366382..366432,366480..366544,366604..367222,367274..367357,367412..367789,367868..368129) I 1 NT_166525.1 Function: MRP1 of H. sapiens and mouse may participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly.; Similarity: MRP1 of H. sapiens belongs to the ATP-binding transport protein family (ABC transporters),and belongs to the MDR (multidrug resistance) subfamily.; Title: strong similarity to multidrug resistance protein MRP1 - Homo sapiens; plasma membrane; See PMID 8098549; See PMID 8649356; See PMID 1360704; uncharacterized protein 368129 4983701 An09g01700 Aspergillus niger uncharacterized protein XP_059605837.1 362941 D 5061 CDS An09g01710 4983702 368553..369449 I 1 NT_166525.1 Catalytic activity: epoxide hydrolases catalyze the hydrolysis of an epoxide to a glycol.; Similarity: although the similarity to echA of A. tumefaciens is weak, several other hypothetical protein homologues and some structural feature suggest that the predicted protein could act as a hydrolase, and maybe as an epoxide hydrolase.; Title: similarity to epoxide hydrolase from patent EP879890-A - grobacterium radiobacter; uncharacterized protein 369449 4983702 An09g01710 Aspergillus niger uncharacterized protein XP_001393488.1 368553 D 5061 CDS An09g01730 84591959 complement(join(369853..369988,370049..370093,370143..370383,370472..370601)) I 1 NT_166525.1 hypothetical protein 370601 84591959 An09g01730 Aspergillus niger hypothetical protein XP_059605838.1 369853 R 5061 CDS An09g01740 84591960 370998..>376250 I 1 NT_166525.1 Catalytic activity: FAS1 of S. cerevisiae is a pentafunctional enzyme consisting of the following domains : acetyl transferase, enoyl reductase, dehydratase and malonyl/palmityl transferase.; Function: FAS1 of S. cerevisiae catalyzes the formation of long-chain fatty acids from acetyl-CoA,malonyl-CoA and NADPH, and is therefore necessary for fatty acid biosynthesis.; Remark: C-terminally truncated ORF due to contig border.; Similarity: the predicted protein is also very similar to FasB, the fatty acid synthase of E. nidulans.; Title: strong similarity to beta chain of fatty-acyl-CoA synthase Fas1 - Saccharomyces cerevisiae [truncated ORF]; cytoplasm; See PMID 3528750; See PMID 6311818; See PMID 6330502; See PMID 810348; See PMID 1107031; uncharacterized protein 376250 84591960 An09g01740 Aspergillus niger uncharacterized protein XP_059605839.1 370998 D 5061 CDS An09g01750 4983705 join(<376352..376691,376739..376854,376905..377330,377387..377458) I 1 NT_166525.1 Catalytic activity: Acetyl-CoA+N malonyl-CoA+2N NADPH <=> a long-chain fatty acid+(N+1) CoA+N CO(2)+2N NADP(+).; Function: fatty-acid synthases function in the synthesis of long-chain fatty acids from acety-CoA,malonyl-CoA and NADPH.; Title: strong similarity to fatty acid synthase beta subunit fasB - Aspergillus nidulans [truncated ORF]; See PMID 8848053; See PMID 8962148; uncharacterized protein 377458 4983705 An09g01750 Aspergillus niger uncharacterized protein XP_001393490.3 376352 D 5061 CDS An09g01760 4983707 complement(join(377905..378067,378097..378572,378671..378778)) I 1 NT_166525.1 Title: similarity to hypothetical protein YBR096w -Saccharomyces cerevisiae; uncharacterized protein 378778 4983707 An09g01760 Aspergillus niger uncharacterized protein XP_059601294.1 377905 R 5061 CDS An09g01770 84591961 complement(join(378872..379039,379193..379330,379455..379541)) I 1 NT_166525.1 hypothetical protein 379541 84591961 An09g01770 Aspergillus niger hypothetical protein XP_059601295.1 378872 R 5061 CDS An09g01790 4983710 complement(380813..381601) I 1 NT_166525.1 Title: strong similarity to hypothetical protein AAD34553.1 - Aspergillus terreus; uncharacterized protein 381601 4983710 An09g01790 Aspergillus niger uncharacterized protein XP_001393494.1 380813 R 5061 CDS An09g01800 4983711 complement(381929..383314) I 1 NT_166525.1 Function: the trichothecene 3-O-acetyltransferase TRI101 from F. sporotrichioides converts isotrichodermol to isotrichodermin.; Function: transfection of TRI101 of F. sporotrichioides into S. cerevisiae, protects the cell from the trichothecene 4,15-diacetoxyscirpenol. Antibiotic-producing organisms, including fungi, protect themselves from their own toxins by e. g. metabolic alteration of the compound.; Pathway: F. sporotrichioides TRI101 is required for the biosynthesis of T-2 toxin.; Remark: Fusarium and related fungi produce trichothecenes which are sesquiterpenoid epoxides that act as potent inhibitors of eukaryotic protein synthesis.; Title: strong similarity to trichothecene 3-O-acetyltransferase TRI101 - Fusarium sporotrichioides; See PMID 10583973; uncharacterized protein 383314 4983711 An09g01800 Aspergillus niger uncharacterized protein XP_001393495.1 381929 R 5061 CDS An09g01810 4983712 join(383719..383752,383818..383869,383918..384050,384116..384401,384440..384975) I 1 NT_166525.1 Function: enzyme is capable of reducing a variety of alpha-ketolactones, alpha-ketolactams and diketones.; Title: strong similarity to ketoreductase from patent EP918090-A - Saccharomyces cerevisiae; See PMID 10951208; uncharacterized protein 384975 4983712 An09g01810 Aspergillus niger uncharacterized protein XP_059601296.1 383719 D 5061 CDS An09g01820 4983713 complement(join(385184..386131,386183..386623,386686..386823,386883..386975)) I 1 NT_166525.1 Catalytic activity: 4-coumarate-CoA ligase catalyzes the conversion of ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA.; Function: key enzyme of phenylpropanoid metabolism.; Pathway: phenylpropanoid biosynthesis.; Title: strong similarity to 4-coumarate-CoA ligase 4CL - Arabidopsis thaliana; See PMID 7640359; uncharacterized protein 386975 4983713 An09g01820 Aspergillus niger uncharacterized protein XP_001393497.1 385184 R 5061 CDS An09g01830 4983714 complement(join(387291..387558,387614..387996,388047..388612,388705..388936)) I 1 NT_166525.1 Catalytic activity: (R)-6-hydroxynicotine + H(2)O + O(2) = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H(2)O(2).; Cofactor: FAD flavoprotein.; Function: catalyzes the oxygen-dependent degradation of 6-hydroxynicotine into 6-hydroxypyrid-N-methylosmine.; Pathway: degradation of nicotine.; Title: similarity to 6-hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 2680607; See PMID 3622516; See PMID 3905431; See PMID 2115879; uncharacterized protein 388936 4983714 An09g01830 Aspergillus niger uncharacterized protein XP_059601297.1 387291 R 5061 CDS An09g01840 4983715 389489..390820 I 1 NT_166525.1 Catalytic activity: salicylate + NADH + H(+) + O(2) = chatechol + NAD(+) + H(2)O + CO(2).; Cofactor: FAD flavoprotein.; Function: salicylate 1-monooxygenase catalyzes the formation of catechol from salicylate.; Pathway: nahpthalene catabolism and phenylalanine metabolism.; Title: strong similarity to salicylate hydroxylase nahG - Pseudomonas putida; uncharacterized protein 390820 4983715 An09g01840 Aspergillus niger uncharacterized protein XP_001393499.3 389489 D 5061 CDS An09g01850 4983716 complement(join(391004..391179,391249..391325,391389..392002,392061..392446,392515..392656,392713..392784)) I 1 NT_166525.1 Catalytic activity: benzoate 4-monooxygenases convert benzoate + NADPH(2) + O(2) to 4-hydroxybenzoate + NADP + H(2)O.; Function: in A. niger bphA and cprA are the two cytochrome P450s required for the para-hydroxylation of benzoate.; Induction: A. niger bphA is inducible by benzoate.; Pathway: bphA of A. niger is an enzyme in the phenylalanine metabolism.; Title: strong similarity to benzoate 4-monooxygenase cytochrome P450 53 bphA - Aspergillus niger; See PMID 10852481; uncharacterized protein 392784 4983716 An09g01850 Aspergillus niger uncharacterized protein XP_001393500.1 391004 R 5061 CDS An09g01860 4983717 join(393519..394133,394195..401433) I 1 NT_166525.1 Function: required for conidial pigmentation in A. fumigatus.; Pathway: involved in dihydroxynaphthalene-melanin biosynthesis.; Remark: pigmentation is important for infection in A. fumigatus.; Title: strong similarity to polyketide synthase wA -Aspergillus nidulans; uncharacterized protein 401433 4983717 An09g01860 Aspergillus niger uncharacterized protein XP_059601298.1 393519 D 5061 CDS An09g01870 4983718 complement(join(401932..403117,403176..403332,403396..403624)) I 1 NT_166525.1 Title: similarity to hypothetical binuclear zinc transcription factor PRF - Nectria haematococca; uncharacterized protein 403624 4983718 An09g01870 Aspergillus niger uncharacterized protein XP_001393502.1 401932 R 5061 CDS An09g01880 4983719 complement(404798..405838) I 1 NT_166525.1 Function: lovC from A. terreus interacts with LNKS and is necessary for the correct processing of the growing polyketide chain and production of dihydromonacolin L.; Function: lovC from A. terreus is an accessory protein that modulates polyketide synthase activity during lovastatin biosynthesis.; Remark: it is assumed, that the ORF is encoded in a polyketide biosynthesis gene cluster, as proximal sequences encode homologues of further proteins for lovastatin synthesis (lovF of A. terreus and alb1 of A. fumigatus).; Similarity: the ORF shows similarity to several oxidoreductases, some of the known are quinone oxidoreductases or/and involved in toxin biosynthesis.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994; uncharacterized protein 405838 4983719 An09g01880 Aspergillus niger uncharacterized protein XP_001393503.1 404798 R 5061 CDS An09g01890 84591962 join(405943..406003,406127..406197,406259..406549) I 1 NT_166525.1 hypothetical protein 406549 84591962 An09g01890 Aspergillus niger hypothetical protein XP_059601299.1 405943 D 5061 CDS An09g01900 4983721 complement(join(406867..407433,407510..407551)) I 1 NT_166525.1 Title: similarity to hypothetical protein mlr5144 -Mesorhizobium loti; uncharacterized protein 407551 4983721 An09g01900 Aspergillus niger uncharacterized protein XP_001393505.1 406867 R 5061 CDS An09g01910 4983722 join(407877..408137,408193..408376,408584..408735,408853..408938,408985..409229,409369..409626,409743..409798) I 1 NT_166525.1 Function: TetA of A. tumefaciens C58 confers resistance to tetracyclin and some of it's derivatives.; Repression: TetA expression in A. tumefaciens C58 is repressed by the transcriptional regulator TetR.; Title: similarity to tetracyclin resistance protein tetA - Agrobacterium tumefaciens; See PMID 9882678; uncharacterized protein 409798 4983722 An09g01910 Aspergillus niger uncharacterized protein XP_059601300.1 407877 D 5061 CDS An09g01920 4983723 complement(join(410817..411072,411127..411506,411567..411955,412027..412243,412313..412540)) I 1 NT_166525.1 Catalytic activity: (R)-6-hydroxynicotine + H(2)O + O(2) = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H(2)O(2).; Cofactor: FAD flavoprotein.; Function: catalyzes the oxygen-dependent degradation of 6-hydroxynicotine into 6-hydroxypyrid-N-methylosmine.; Pathway: degradation of nicotine.; Title: similarity to 6-hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 2680607; See PMID 3622516; See PMID 3905431; See PMID 2115879; uncharacterized protein 412540 4983723 An09g01920 Aspergillus niger uncharacterized protein XP_001393507.1 410817 R 5061 CDS An09g01930 4983724 join(413170..413358,413419..413505,413574..413631,413689..414022,414080..414605,414665..415340,415393..418314,418383..420157,420236..420538,420612..421418) I 1 NT_166525.1 Function: lovF from A. terreus specifies formation of 2-methylbutyrate.; Remark: it is assumed, that the ORF is encoded in a polyketide biosynthesis gene cluster, as proximal sequences encode homologues of further proteins for lovastatin synthesis (lovC of A. terreus and alb1 of A. fumigatus).; Title: strong similarity to lovastatin diketide synthase lovF - Aspergillus terreus; See PMID 10381407; See PMID 11375168; See PMID 11386351; See PMID 11412974; uncharacterized protein 421418 4983724 An09g01930 Aspergillus niger uncharacterized protein XP_059601301.1 413170 D 5061 CDS An09g01940 4983725 complement(join(421812..421964,422090..422718,422769..422925)) I 1 NT_166525.1 Function: involved in 7-aminocholesterol resistance; 7-aminocholesterol is a strong inhibitor of yeast and of Gram+-bacteria proliferation.; Remark: the protein shows also strong similarity to molasses toxicity resisitance protein RTM1 from S. cerevisiae patent WO9514774-A2.; Title: strong similarity to 7-aminocholesterol resistance protein Rta1 - Saccharomyces cerevisiae; uncharacterized protein 422925 4983725 An09g01940 Aspergillus niger uncharacterized protein XP_001393509.3 421812 R 5061 CDS An09g01950 4983726 join(423444..424421,424476..424790,424845..425011,425068..425233) I 1 NT_166525.1 Function: catalyzes the hydroxylation at C-15 of isotrichodermin.; Pathway: trichothecene bioynthesis; trichothecenes are sesquiterpenoid toxins that act by inhibiting protein biosynthesis.; Remark: belong to the cytochrome P450 family.; Title: strong similarity to cytochrome P450 monooxygenase TRI11 - Fusarium sporotrichioides; See PMID 9435078; uncharacterized protein 425233 4983726 An09g01950 Aspergillus niger uncharacterized protein XP_059601302.1 423444 D 5061 CDS An09g01960 84591963 join(425555..425632,425736..425849,425949..425986,426092..426191) I 1 NT_166525.1 hypothetical protein 426191 84591963 An09g01960 Aspergillus niger hypothetical protein XP_059601303.1 425555 D 5061 CDS An09g01970 4983728 join(426978..427308,427394..428097) I 1 NT_166525.1 Title: similarity to oxidoreductase from patent WO0100844 - Corynebacterium glutamicum; uncharacterized protein 428097 4983728 An09g01970 Aspergillus niger uncharacterized protein XP_059601304.1 426978 D 5061 CDS An09g01980 84591964 join(428275..428360,428450..428536,428606..428702) I 1 NT_166525.1 hypothetical protein 428702 84591964 An09g01980 Aspergillus niger hypothetical protein XP_059601305.1 428275 D 5061 CDS An09g01990 4983730 join(428974..429030,429133..429250,429296..429948,430000..430284) I 1 NT_166525.1 Catalytic activity: branched-chain amino acid + 2-oxoglutarate = corresponding keto acid + L-glutamate.; Cofactor: pyridoxal-phosphate.; Function: catalyzes the first reaction in the catabolism of L-isoleucine, L-leucine, L-valine and L-methionine.; Title: strong similarity to branched-chain amino acid aminotransferase bcaT - Lactococcus lactis; See PMID 10831406; uncharacterized protein 430284 4983730 An09g01990 Aspergillus niger uncharacterized protein XP_059601306.1 428974 D 5061 CDS An09g02000 4983731 complement(join(431098..431774,431837..432202,432248..432502,432548..432578,432658..432753,432830..432928)) I 1 NT_166525.1 Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.; Cofactor: heme-thiolate.; Title: strong similarity to cytochrome P450 -Rhodotorula minuta; See PMID 7764227; See PMID 8002981; See PMID 8882724; See PMID 9349702; uncharacterized protein 432928 4983731 An09g02000 Aspergillus niger uncharacterized protein XP_059601307.1 431098 R 5061 CDS An09g02010 4983732 join(433797..433843,433924..433950,434019..434473,434546..438870) I 1 NT_166525.1 Catalytic activity: acetyl-CoA+N malonyl-CoA+2N NADPH <=> a long-chain fatty acid+(N+1) CoA+N CO(2)+2N NADP(+).; Function: fatty-acid synthases function in the synthesis of long-chain fatty acids from acety-CoA,malonyl-CoA and NADPH.; Phenotype: A. nidulans mutant for fasA are unable to grow on minimal medium unless supplemented with myristic acid.; Title: strong similarity to fatty acid synthase alpha subunit fasA - Aspergillus nidulans; See PMID 8848053; See PMID 8962148; uncharacterized protein 438870 4983732 An09g02010 Aspergillus niger uncharacterized protein XP_059601308.1 433797 D 5061 CDS An09g02020 4983733 complement(join(439270..439454,439507..439876,439934..441487,441533..441790)) I 1 NT_166525.1 Function: the molecular function of MxA remains elusive, although its antiviral activities are well recognized.; Induction: MxA (also known as Mx1 or p78) is a mammalian protein induced by Interferon- alpha and beta,and to much less extent by Interferon-gamma.; Similarity: MxA of H. sapiens and the predicted ORF contain dynamin domains; all dynamins, comprising human MxA, hydrolyse GTP.; Title: strong similarity to interferon-regulated resistance GTP-binding protein MxA - Homo sapiens; See PMID 2607176; See PMID 10702310; See PMID 2154602; See PMID 2161946; See PMID 2481229; uncharacterized protein 441790 4983733 An09g02020 Aspergillus niger uncharacterized protein XP_059601309.1 439270 R 5061 CDS An09g02030 84591965 complement(join(442146..442527,442657..442731,442922..442965)) I 1 NT_166525.1 hypothetical protein 442965 84591965 An09g02030 Aspergillus niger hypothetical protein XP_059601310.1 442146 R 5061 CDS An09g02040 4983735 complement(443255..444016) I 1 NT_166525.1 Title: strong similarity to hypothetical protein slr1870 - Synechocystis sp.; uncharacterized protein 444016 4983735 An09g02040 Aspergillus niger uncharacterized protein XP_001393519.1 443255 R 5061 CDS An09g02050 4983736 join(444801..444910,444981..445606,445677..445786) I 1 NT_166525.1 Pathway: the two enzymes catalyze two slightly different reactions within the butanoate metabolism.; Similarity: the predicted protein shows strong similarity both to mammalian peroxisomal enoyl-CoA hydratase (EC 4. 2. 1. 17), and to bacterial 3-hydroxybutryl-CoA dehydratase (EC 4. 2. 1. 55).; Title: strong similarity to 3-hydroxybutryl-CoA dehydratase crt - Clostridium acetobutylicum; See PMID 5057466; See PMID 8655474; uncharacterized protein 445786 4983736 An09g02050 Aspergillus niger uncharacterized protein XP_001393520.1 444801 D 5061 CDS An09g02060 4983737 join(446943..447126,447418..447534,447591..448012,448053..448201,448246..448739,448787..448923,448961..449680,449813..450985) I 1 NT_166525.1 Similarity: although the length of the predicted ORF is very different from other cholesterol oxidases, and the C- terminal is not conserved, some structural domains suggest that it might have some oxidase activity.; Similarity: the ORF encoded protein shows also weak similarity to putative cholesterol oxidase choD from Mycobacterium leprae.; Similarity: the similarity to choD and other cholesterol oxidases is stronger in the N-terminal part of the molecule.; Title: strong similarity to hypothetical protein CAD21388.1 - Neurospora crassa; uncharacterized protein 450985 4983737 An09g02060 Aspergillus niger uncharacterized protein XP_059601311.1 446943 D 5061 CDS An09g02080 4983739 451708..453294 I 1 NT_166525.1 Remark: the transposable element Tan1 in A. niger has a structure like IR-ORF-IR-IR-Vader-IR, where IR means Inverted Repeat, Vader is an inactive transposable element,present in approximately 15 copoies in the genome, and the unique ORF encodes a putative transposase homologous to Fusarium oxysporum Fot1 and Magnaporthe grisea Pot2.; Title: strong similarity to transposase Tan1 -Aspergillus niger; See PMID 9003286; uncharacterized protein 453294 4983739 An09g02080 Aspergillus niger uncharacterized protein XP_001393522.1 451708 D 5061 CDS An09g02090 4983740 complement(join(453705..453934,454004..454328)) I 1 NT_166525.1 Title: weak similarity to hypothetical protein encoded by An12g05320 - Aspergillus niger; uncharacterized protein 454328 4983740 An09g02090 Aspergillus niger uncharacterized protein XP_059601312.1 453705 R 5061 CDS An09g02100 4983741 complement(join(455415..455432,455504..455614,455719..456512,456552..459958,460035..460308,460442..460870,460942..463873)) I 1 NT_166525.1 Catalytic activity: polyketide synthases are multifunctional enzymes, containing oxidoreductase,transferase and dehydratase activity.; Pathway: polyketides are generated from acetate by a pathway similar to the fatty acid metabolism, where some reduction or dehydratation reactions can be suppressed at specific biosynthetic steps, resulting in a much wider range of products, constituting a large family of often biologically active secondary metabolites.; Similarity: the predicted ORF shows strong similarity to many described or hypothetical polyketide syntases.; Title: strong similarity to polyketide synthase nysI - Streptomyces noursei; See PMID 10873841; uncharacterized protein 463873 4983741 An09g02100 Aspergillus niger uncharacterized protein XP_059601313.1 455415 R 5061 CDS An09g02110 84591966 join(465108..465161,465276..465340,465387..465434,465572..465664,465936..466050) I 1 NT_166525.1 Title: questionable ORF; uncharacterized protein 466050 84591966 An09g02110 Aspergillus niger uncharacterized protein XP_059601314.1 465108 D 5061 CDS An09g02120 4983743 466312..468819 I 1 NT_166525.1 Similarity: the N-terminal part of the predicted ORF shows indeed a good similarity to the isochorismatase family of hydrolase enzymes.; Similarity: the N-terminal region of the predicted ORF shows some similarity to putative proteins similar to pyrazinamidase/nicotinamidase; the similarity to hypothetical protein PA3306 of P. aeruginosa involves a 200 amino acids-long stretch in the central part of the predicted protein.; Title: similarity to hypothetical protein PA3306 -Pseudomonas aeruginosa; uncharacterized protein 468819 4983743 An09g02120 Aspergillus niger uncharacterized protein XP_001393526.1 466312 D 5061 CDS An09g02130 84591967 complement(469097..469309) I 1 NT_166525.1 Similarity: some similarity with a short stretch of a hypothetical O-succinylhomoserine sulfhydrylase of Mycobacterium leprae.; hypothetical protein 469309 84591967 An09g02130 Aspergillus niger hypothetical protein XP_059601315.1 469097 R 5061 CDS An09g02140 84591968 complement(join(469664..469804,469905..469963,470005..470162,470374..470477)) I 1 NT_166525.1 hypothetical protein 470477 84591968 An09g02140 Aspergillus niger hypothetical protein XP_059601316.1 469664 R 5061 CDS An09g02150 4983746 join(470518..470813,470884..471925) I 1 NT_166525.1 Function: paxM of P. paxilli is comprised within an indole-diterpene gene cluster, but its function is putatively induced by homology.; Similarity: the predicted ORF shows similarity to different, mainly putative, monooxygenases.; Title: strong similarity to hypothetical monooxygenase paxM - Penicillium paxilli; See PMID 11169115; uncharacterized protein 471925 4983746 An09g02150 Aspergillus niger uncharacterized protein XP_001393529.1 470518 D 5061 CDS An09g02160 4983747 join(472482..472596,472647..473317) I 1 NT_166525.1 Catalytic activity: deacetylation of rhamnogalacturonan.; Function: rhamnogalacturonan acetylesterase acts in synergy with rhamnogalacturonase A as well as rhamnogalacturonase B from A. aculeatus in the degradation of apple pectin rhamnogalacturonan.; Gene-ID: rgaeA; Induction: the expression of rhamnogalacturonan degrading enzymes by A. acculeatus is regulated at the level of transcription and is subjected to carbon catabolite repression by glucose.; Similarity: the predicted ORF is about 70% identical to the biochemically characterized rhamnogalacturonan acetylesterase of A. aculeatus, which was therefore used for annotation.; Similarity: the predicted ORF is identical to the cloned A. niger gene; the enzymatic characterization of this gene has not been published.; See PMID 7592973; rhamnogalacturonan acetyl esterase rgaeA-Aspergillus niger 473317 rgaeA 4983747 rgaeA Aspergillus niger rhamnogalacturonan acetyl esterase rgaeA-Aspergillus niger XP_059601317.1 472482 D 5061 CDS An09g02170 84591969 complement(join(473831..473922,473994..474171)) I 1 NT_166525.1 Title: weak similarity to precursor of pertussis toxin chain S3 - Bordetella pertussis; See PMID 3704651; uncharacterized protein 474171 84591969 An09g02170 Aspergillus niger uncharacterized protein XP_059601318.1 473831 R 5061 CDS An09g02180 4983749 complement(join(474874..475179,475250..475586,475646..475811,475858..475945)) I 1 NT_166525.1 Similarity: A. niger EST EMBLEST:BE760925 covers part of the last exon and part of the putative 3'UTR of the gene.; Title: strong similarity to phospholipase A1 from patent JP10155493-A - Aspergillus oryzae; See PMID 2253331; uncharacterized protein 475945 4983749 An09g02180 Aspergillus niger uncharacterized protein XP_001393532.1 474874 R 5061 CDS An09g02190 84591970 join(476309..476428,476679..476827,476915..476927,477026..477233,477295..477407) I 1 NT_166525.1 hypothetical protein 477407 84591970 An09g02190 Aspergillus niger hypothetical protein XP_059601319.1 476309 D 5061 CDS An09g02200 84591971 complement(join(477831..477851,477963..477982,478020..478170,478615..478648,478796..478827)) I 1 NT_166525.1 Title: questionable ORF; uncharacterized protein 478827 84591971 An09g02200 Aspergillus niger uncharacterized protein XP_059601320.1 477831 R 5061 CDS An09g02210 4983753 join(479099..479286,479342..479720,479808..480476,480556..480819) I 1 NT_166525.1 Similarity: the patented protein from A. chrysogenum is involved in biosynthesis of cephalosporin C and can be used to improve the fermentation ability of Acremonium chrysogenum.; Similarity: the predicted ORF also shows significant similarity to many putative or described membrane transporters.; Title: strong similarity to protein involved in cephalosporin C biosynthesis from patent JP09009966-A -Acremonium chrysogenum; uncharacterized protein 480819 4983753 An09g02210 Aspergillus niger uncharacterized protein XP_001393535.1 479099 D 5061 CDS An09g02220 4983754 complement(481141..484638) I 1 NT_166525.1 Function: human Rev1 transferase may play a critical role during mutagenic translesion DNA synthesis bypassing a template AP site in human cells.; Function: the human Rev1 protein is a dCMP transferase that specifically inserts a dCMP residue opposite to a DNA template G or to a uracile residue, or to an apurinic/apyrimidinic (AP) site.; Similarity: the Rev1 protein of H. sapiens is a member of the family of translesion DNA polymerases.; Title: strong similarity to deoxycytidyl transferase Rev1 - Homo sapiens; See PMID 10536157; See PMID 11278384; uncharacterized protein 484638 4983754 An09g02220 Aspergillus niger uncharacterized protein XP_059601321.1 481141 R 5061 CDS An09g02230 4983755 complement(join(485588..485838,485914..486025)) I 1 NT_166525.1 Similarity: the predicted ORF contains domains conserved in protein families with unknown function (see PFAM and BLOCKS).; Title: similarity to hypothetical protein BAA10688.1 - Synechocystis sp.; uncharacterized protein 486025 4983755 An09g02230 Aspergillus niger uncharacterized protein XP_001393537.1 485588 R 5061 CDS An09g02240 4983756 complement(486755..488569) I 1 NT_166525.1 Remark: in the literature (see citations) there are two reports of N-acetyl-beta-D-glucosaminidases, extracted respectively from A. niger and A. nidulans, which were extensively biochemically characterized.; Remark: unfortunately the two enzymes were not cloned; the pI of the enzymes corresponds to the one calculated for the predicted ORF; the difference in MW could be explained either by polymerization or extensive glycosilation.; Similarity: the predicted ORF is almost identical to A. nidulans nagA gene, coding for an N-acetyl-beta-D-glucosaminidase (unpublished).; Title: strong similarity to beta-N-acetylhexosaminidase from patent WO9839459-A1 -Penicillium chrysogenum; See PMID 2693201; See PMID 9428156; uncharacterized protein 488569 4983756 An09g02240 Aspergillus niger uncharacterized protein XP_001393538.1 486755 R 5061 CDS An09g02250 4983757 join(489636..492158,492213..492842,492927..493274) I 1 NT_166525.1 Function: RAD5 of S. cerevisiae has single-stranded DNA-dependent ATPase activity, and is involved in error-free DNA repair.; Remark: RAD5 of S. cerevisiae is also called REV2,SNM2 or YLR032W.; Similarity: A. niger EST EMBLEST:BE76059 covers the last part of the reading frame and part of the putative 3'UTR.; Similarity: the predicted ORF shows equally strong similarity to the S. cerevisiae RAD5 protein, and its homologue Rad8 of S. pombe.; Title: strong similarity to DNA repair protein Rad5 - Saccharomyces cerevisiae; nucleus; See PMID 8290359; See PMID 9016623; See PMID 9637242; See PMID 10430580; See PMID 1324406; uncharacterized protein 493274 4983757 An09g02250 Aspergillus niger uncharacterized protein XP_059601322.1 489636 D 5061 CDS An09g02260 4983758 join(494364..494676,494730..494854,494901..495083,495131..495227,495272..495343,495403..495441,495505..495734,495806..496034,496106..496242) I 1 NT_166525.1 Function: hapE of P. fluorescens catalyses the NADPH-dependent oxidation of 4-hydroxyacetophenone to 4-hydroxyphenyl acetate.; Remark: closest manual homologue (BLASTP) is TREMBL:AF355751_1.; Similarity: the predicted ORF shows moderate similarity to several hypothetical and known monooxygenases with different specificity.; Title: similarity to 4-Hydroxyacetophenone monooxygenase hapE - Pseudomonas fluorescens; See PMID 11322873; uncharacterized protein 496242 4983758 An09g02260 Aspergillus niger uncharacterized protein XP_001393540.3 494364 D 5061 CDS An09g02270 4983759 complement(join(496428..497465,497529..497700,497751..497835,497873..498018,498062..498399)) I 1 NT_166525.1 Catalytic activity: triacylglycerol + H2O = diacylglycerol + a carboxylate, and diacylglycerol + H2O = monoacylglycerol + a carboxylate.; Title: strong similarity to triacylglycerol lipase lipI - Geotrichum candidum; extracellular/secretion proteins; See PMID 7578238; See PMID 8306978; uncharacterized protein 498399 4983759 An09g02270 Aspergillus niger uncharacterized protein XP_059601323.1 496428 R 5061 CDS An09g02280 4983760 join(499571..499877,499979..500069,500155..500221,500295..500632,500719..500845,500917..501069) I 1 NT_166525.1 Function: PRP4 of S. cerevisiae is necessary for spliceosome assembly and for splicing of pre-mRNA.; Remark: PRP4 of S. cerevisiae is also known as RNA4 or YPR178w.; Similarity: the similarity to PRP4 of S. cerevisiae involves only the N-terminal half of the predicted protein.; Title: similarity to U4/U6 snRNP 52kD protein Prp4 -Saccharomyces cerevisiae; See PMID 2528686; See PMID 3322934; See PMID 6094499; See PMID 7050675; See PMID 342911; uncharacterized protein 501069 4983760 An09g02280 Aspergillus niger uncharacterized protein XP_059601324.1 499571 D 5061 CDS An09g02290 4983761 complement(join(501558..501649,501697..502502,502551..505264)) I 1 NT_166525.1 Catalytic activity: UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n =UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)](n+1).; Function: chitin synthase chsE of A. nidulans plays a major role in cell wall biogenesis.; Similarity: chsE of A. nidulans belongs to the chitin synthase class IV subfamily.; Title: strong similarity to chitin synthase chsE -Aspergillus nidulans; See PMID 8810520; uncharacterized protein 505264 4983761 An09g02290 Aspergillus niger uncharacterized protein XP_001393543.1 501558 R 5061 CDS An09g02300 84591972 join(505486..505522,505628..505777,505945..506075) I 1 NT_166525.1 hypothetical protein 506075 84591972 An09g02300 Aspergillus niger hypothetical protein XP_059601325.1 505486 D 5061 CDS An09g02310 84591973 complement(join(507762..508484,508551..508625)) I 1 NT_166525.1 hypothetical protein 508625 84591973 An09g02310 Aspergillus niger hypothetical protein XP_059601326.1 507762 R 5061 CDS An09g02320 4983764 join(509680..509895,509973..510487,510546..510972) I 1 NT_166525.1 Function: the pathogenicity protein PTH11 functions at the cell cortex as an upstream effector of appressorium differentiation in response to surface cues.; Localization: a PTH11-green fluorescent protein fusion was localized to the cell membrane and vacuoles.; Remark: the A. niger protein is 250 amino acids shorter than PTH11.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529; uncharacterized protein 510972 4983764 An09g02320 Aspergillus niger uncharacterized protein XP_001393546.1 509680 D 5061 CDS An09g02330 4983765 complement(join(511232..511237,511375..511791,511874..512017)) I 1 NT_166525.1 Title: weak similarity to hydrolase protein YODH from patent WO9927081-A2 - Bacillus subtilis; uncharacterized protein 512017 4983765 An09g02330 Aspergillus niger uncharacterized protein XP_059601327.1 511232 R 5061 CDS An09g02340 4983766 complement(join(512787..513370,513429..513603)) I 1 NT_166525.1 Function: phosphatidylethanolamine binding protein D1 is thought to play a role in transport or signal mechanisms between membranes and the cytoplasm.; Phenotype: in wild-type 'indeterminate' tomato plants, inflorescences are separated by three vegetative nodes. In 'determinate' plants homozygous for the recessive allele of the SELF-PRUNING (SP) gene, sympodial segments develop progressively fewer nodes until the shoot is terminated by two consecutive inflorescences.; Similarity: the A. niger protein also shows similarity to the hypothetical phosphatidylethanolamine binding protein D1 Ovd1 of Onchocerca volvulus and contains corresponding PFAM and BLOCKS domains.; Title: similarity to self-pruning protein SP -Lycopersicon esculentum; See PMID 9570763; mitochondrial 54S ribosomal protein mL38 513603 4983766 An09g02340 Aspergillus niger mitochondrial 54S ribosomal protein mL38 XP_001393548.1 512787 R 5061 CDS An09g02350 84591974 complement(join(513981..514069,514311..514503)) I 1 NT_166525.1 hypothetical protein 514503 84591974 An09g02350 Aspergillus niger hypothetical protein XP_059601328.1 513981 R 5061 CDS An09g02360 84591975 complement(514964..515317) I 1 NT_166525.1 hypothetical protein 515317 84591975 An09g02360 Aspergillus niger hypothetical protein XP_059601329.1 514964 R 5061 CDS An09g02370 4983769 join(516685..516735,516809..516862,516899..517058,517105..517449,517499..518309,518460..518598) I 1 NT_166525.1 Function: SlpE of S. lividans is required for growth on minimal media.; Title: similarity to proteinase SlpE - Streptomyces lividans; See PMID 7592364; uncharacterized protein 518598 4983769 An09g02370 Aspergillus niger uncharacterized protein XP_059601330.1 516685 D 5061 CDS An09g02380 4983770 complement(519288..519974) I 1 NT_166525.1 Title: similarity to hypothetical protein CG17807 -Drosophila melanogaster; uncharacterized protein 519974 4983770 An09g02380 Aspergillus niger uncharacterized protein XP_001393552.1 519288 R 5061 CDS An09g02390 4983771 complement(join(520412..521491,521551..521712)) I 1 NT_166525.1 Catalytic activity: AAT2 of S. cerevisiae catalyzes L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.; Similarity: AAT2 of S. cerevisiae belongs to class-I of pyridoxal-phosphate-dependent aminotransferases.; Title: strong similarity to aspartate aminotransferase Aat2 - Saccharomyces cerevisiae; See PMID 1859361; See PMID 9655342; uncharacterized protein 521712 4983771 An09g02390 Aspergillus niger uncharacterized protein XP_001393553.1 520412 R 5061 CDS An09g02400 84591976 complement(join(522910..523035,523083..523199)) I 1 NT_166525.1 hypothetical protein 523199 84591976 An09g02400 Aspergillus niger hypothetical protein XP_059601331.1 522910 R 5061 CDS An09g02410 4983773 523245..524873 I 1 NT_166525.1 Remark: chip3 was found in a differential-display for the isolation of genes required for the differentiation into an infection structure called the appressorium.; Title: similarity to hard surface induced protein 3 chip3 - Glomerella cingulata; See PMID 10940006; uncharacterized protein 524873 4983773 An09g02410 Aspergillus niger uncharacterized protein XP_001393555.1 523245 D 5061 CDS An09g02420 84591977 join(526946..527156,527233..527330,527386..527442) I 1 NT_166525.1 hypothetical protein 527442 84591977 An09g02420 Aspergillus niger hypothetical protein XP_059601332.1 526946 D 5061 CDS An09g02430 4983775 complement(528331..529137) I 1 NT_166525.1 Title: similarity to esterase EST2 - Acetobacter pasteurianus; uncharacterized protein 529137 4983775 An09g02430 Aspergillus niger uncharacterized protein XP_001393557.1 528331 R 5061 CDS An09g02440 4983776 join(529676..529807,529860..530011,530075..530310,530366..530500,530614..530669) I 1 NT_166525.1 Function: the homoprotocatechuic acid (HPC) pathway is a typical catabolic sequence for converting peripheral metabolites into intermediates of central metabolism.; Pathway: hpcH is involved in the meta-fission pathway for homoprotocatechuic acid (HPC) catabolism.; Title: strong similarity to 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase hpcH -Escherichia coli; See PMID 8529896; uncharacterized protein 530669 4983776 An09g02440 Aspergillus niger uncharacterized protein XP_059601333.1 529676 D 5061 CDS An09g02450 84591978 complement(join(531660..531917,531958..532250,532422..532425)) I 1 NT_166525.1 hypothetical protein 532425 84591978 An09g02450 Aspergillus niger hypothetical protein XP_059601334.1 531660 R 5061 CDS An09g02460 4983778 complement(532532..533905) I 1 NT_166525.1 Function: L. pneumophila DotA is one of the factors inhibiting the fusion of the endosome to the lysosome.; Remark: an alternative name for L. pneumophila dotA is dlpA.; Remark: the N-term and the C-term of the A. niger protein show similarity to the C-term of dotA.; Title: similarity to inhibitor of endosome-lysosome fusion dlpA - Legionella pneumophila; endosome; See PMID 11207624; See PMID 9632267; uncharacterized protein 533905 4983778 An09g02460 Aspergillus niger uncharacterized protein XP_001393560.1 532532 R 5061 CDS An09g02470 4983779 join(534700..534896,534966..535471,535523..535956) I 1 NT_166525.1 Title: similarity to protein fragment SEQ ID NO:24319 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 535956 4983779 An09g02470 Aspergillus niger uncharacterized protein XP_059601335.1 534700 D 5061 CDS An09g02480 84591979 complement(join(536000..536274,536361..536417,536587..536698)) I 1 NT_166525.1 hypothetical protein 536698 84591979 An09g02480 Aspergillus niger hypothetical protein XP_059601336.1 536000 R 5061 CDS An09g02490 4983781 complement(join(<537387..538431,538488..538521)) I 1 NT_166525.1 Function: FLU1 of C. albicans facilitates resistance to fluconazole and cycloheximide in the fluconazole-hypersensitive S. cerevisiae strain YKKB-13 lacking the ABC (ATP-binding cassette) transporter gene PDR5.; Remark: the A. niger protein is C-terminally truncated due to the end of the contig.; Similarity: FLU1 of C. albicans is a member of the major falicitator superfamily.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans [truncated ORF]; See PMID 11065353; uncharacterized protein 538521 4983781 An09g02490 Aspergillus niger uncharacterized protein XP_001393563.3 537387 R 5061 CDS An09g02500 84591980 join(538556..538578,538701..538808,538931..539041,539104..539189,539260..539331,539659..539729,539828..539893,539985..540074) I 1 NT_166525.1 Title: weak similarity to hypothetical adult male testis cDNA clone:4933407G07 - Mus musculus; uncharacterized protein 540074 84591980 An09g02500 Aspergillus niger uncharacterized protein XP_059601337.1 538556 D 5061 CDS An09g02510 4983783 join(540726..540736,540811..540865,540926..541031,541099..541404,541475..541542) I 1 NT_166525.1 Remark: the A. niger protein also shows strong similarity to mouse mpv17 protein, disruption of which leads to nephrotic syndrome and chronic renal failure.; Remark: the A. niger protein also shows strong similarity to mouse peroxisomal membrane protein PMP22. The molecular functions of PMP22 and mpv17 are not known.; Title: strong similarity to hypothetical membrane protein YLR251w - Saccharomyces cerevisiae; uncharacterized protein 541542 4983783 An09g02510 Aspergillus niger uncharacterized protein XP_001393565.1 540726 D 5061 CDS An09g02520 4983784 complement(541818..542591) I 1 NT_166525.1 Similarity: the A. niger protein shows weak similarity to many different protein kinases and contains a PFAM kinase domain.; Title: weak similarity to stress activated protein kinase JNK3 - Rattus norvegicus; deleted EC_number 2.7.1.37; uncharacterized protein 542591 4983784 An09g02520 Aspergillus niger uncharacterized protein XP_001393566.1 541818 R 5061 CDS An09g02530 4983785 complement(join(543956..544246,544280..545310,545375..545405)) I 1 NT_166525.1 Title: strong similarity to hypothetical protein EAA60542.1 - Aspergillus nidulans; uncharacterized protein 545405 4983785 An09g02530 Aspergillus niger uncharacterized protein XP_059601338.1 543956 R 5061 CDS An09g02540 4983786 546524..548569 I 1 NT_166525.1 Title: similarity to hypothetical membrane protein YIL067c - Saccharomyces cerevisiae; uncharacterized protein 548569 4983786 An09g02540 Aspergillus niger uncharacterized protein XP_001393568.1 546524 D 5061 CDS An09g02550 4983787 complement(join(549191..549294,549364..549442,549513..549660,549725..549853,549908..549985,550038..550239,550292..550316,550363..550395,550446..550474,550530..550564,550616..550694,550749..550863,550919..550990,551034..551098,551202..551230,551292..551364,551421..551490,551548..551581,551641..551729)) I 1 NT_166525.1 Function: in A. niger GABA is used as a nitrogen source.; Induction: transcription of the gabA gene of A. nidulans is activated by the transcriptionfactor IntA.; Repression: transcription of the gabA gene of A. nidulans is repressed by the zinc finger transcription factor PacC.; Title: strong similarity to GABA permease gabA -Aspergillus nidulans; See PMID 10320578; uncharacterized protein 551729 4983787 An09g02550 Aspergillus niger uncharacterized protein XP_059601339.1 549191 R 5061 CDS An09g02560 4983788 join(552613..552743,552803..552833,552897..553034,553091..553391,553504..554549) I 1 NT_166525.1 Catalytic activity: N1-acetylspermine + O2 + H2O = N1-acetylspermidine + 3-aminopropanal + H2O2.; Remark: polyamine oxidase catalyses the oxidation of the secondary amino group of spermine, spermidine and their acetyl derivatives. The enzyme plays an important role in the regulation of polyamine intracellular concentration and is a member of the family of flavin-containing amine oxidases.; Similarity: belongs to amine oxidase (flavin-containing) proteins.; Title: similarity to polyamine oxidase PAO - Zea mays; See PMID 9598979; See PMID 10089528; uncharacterized protein 554549 4983788 An09g02560 Aspergillus niger uncharacterized protein XP_059601340.1 552613 D 5061 CDS An09g02580 84591981 complement(555185..556720) I 1 NT_166525.1 Function: YHR gene confers resistance to cycloheximide.; Title: strong similarity to cycloheximide resistance protein CYHR - Candida maltosa; plasma membrane; See PMID 1628836; uncharacterized protein 556720 84591981 An09g02580 Aspergillus niger uncharacterized protein XP_059601341.1 555185 R 5061 CDS An09g02590 4983790 complement(join(558276..558456,558513..559780,559857..559907)) I 1 NT_166525.1 Function: required for the conversion of versicolorin to sterigmatocystin.; Pathway: sterigmatocystin biosynthesis.; Remark: stcS of A. nidulans is also called verB,stcF, cyp59A1, cyp59, or cyp60A2.; Remark: sterigmatocystin is a polyketide-derived mycotoxin.; Title: strong similarity to cytochrome P450 monooxygenase stcS - Aspergillus nidulans; See PMID 7486998; See PMID 10618248; uncharacterized protein 559907 4983790 An09g02590 Aspergillus niger uncharacterized protein XP_059601342.1 558276 R 5061 CDS An09g02600 84591982 complement(join(560115..560171,560384..560563,560693..560773)) I 1 NT_166525.1 hypothetical protein 560773 84591982 An09g02600 Aspergillus niger hypothetical protein XP_059601343.1 560115 R 5061 CDS An09g02610 4983793 561165..562121 I 1 NT_166525.1 Catalytic activity: 2-trans,6-trans-farnesyl diphosphate = trichodiene + pyrophosphate.; Function: trichodiene synthase catalyzes the isomerization and cyclization of farnesyl pyrophosphate to form trichodiene, the first cyclic intermediate in the biosynthetic pathway for trichothecenes; it serves to branch trichothecene biosynthesis from the isoprenoid pathway.; Title: similarity to trichodiene synthase -Gibberella pulicaris; See PMID 1421511; uncharacterized protein 562121 4983793 An09g02610 Aspergillus niger uncharacterized protein XP_001393574.1 561165 D 5061 CDS An09g02620 4983794 complement(join(562395..563760,563825..564546,564662..564813,564856..565093,565158..565232)) I 1 NT_166525.1 Title: similarity to transcription factor ntf1p -Schizosaccharomyces pombe; See PMID 8163491; uncharacterized protein 565232 4983794 An09g02620 Aspergillus niger uncharacterized protein XP_059601344.1 562395 R 5061 CDS An09g02630 84591983 join(569180..569208,569266..569314,569578..569607) I 1 NT_166525.1 Title: questionable ORF; uncharacterized protein 569607 84591983 An09g02630 Aspergillus niger uncharacterized protein XP_059601345.1 569180 D 5061 CDS An09g02640 84591984 join(570073..570137,570348..571254) I 1 NT_166525.1 hypothetical protein 571254 84591984 An09g02640 Aspergillus niger hypothetical protein XP_059601346.1 570073 D 5061 CDS An09g02650 4983797 complement(join(572335..572567,572624..572729,572794..572956,573009..573544,573640..573684,573751..574113,574156..574292,574360..574414)) I 1 NT_166525.1 Function: BiP of O. sativa is involved in protein folding and assembling/disassembling of protein complexes.; Title: weak similarity to dnaK-type molecular chaperone BiP - Oryza sativa; endoplasmatic reticulum; See PMID 9177027; uncharacterized protein 574414 4983797 An09g02650 Aspergillus niger uncharacterized protein XP_001393578.1 572335 R 5061 CDS An09g02660 4983798 575317..576618 I 1 NT_166525.1 hypothetical protein 576618 4983798 An09g02660 Aspergillus niger hypothetical protein XP_001393579.1 575317 D 5061 CDS An09g02670 84591985 join(576892..576894,576945..577064) I 1 NT_166525.1 Title: questionable ORF; uncharacterized protein 577064 84591985 An09g02670 Aspergillus niger uncharacterized protein XP_059601347.1 576892 D 5061 CDS An09g02680 84591986 join(577770..577797,577846..577969,578070..578145,578224..578312,578437..578540,578647..578972,579070..579258) I 1 NT_166525.1 hypothetical protein 579258 84591986 An09g02680 Aspergillus niger hypothetical protein XP_059601348.1 577770 D 5061 CDS An09g02690 84591987 complement(join(579378..579589,579779..579799,579888..579900)) I 1 NT_166525.1 hypothetical protein 579900 84591987 An09g02690 Aspergillus niger hypothetical protein XP_059601349.1 579378 R 5061 CDS An09g02700 4983802 complement(join(580075..580845,580896..581105,581161..581222,581273..581460,581528..581631)) I 1 NT_166525.1 Catalytic activity: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO(2).; Cofactor: thiamine pyrophosphate.; Complex: heterodimer of an alpha and a beta chain.; Function: the branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2); it contains multiple copies of 3 enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).; Title: strong similarity to branched-chain alpha-keto acid dehydrogenase E1 alpha subunit BCHEL1 -Homo sapiens; localisation:mitochondrion; See PMID 2703538; See PMID 2914958; See PMID 3224821; See PMID 8037208; uncharacterized protein 581631 4983802 An09g02700 Aspergillus niger uncharacterized protein XP_001393583.1 580075 R 5061 CDS An09g02705 84591988 join(582126..582182,582247..582327) I 1 NT_166525.1 hypothetical protein 582327 84591988 An09g02705 Aspergillus niger hypothetical protein XP_059601350.1 582126 D 5061 CDS An09g02710 4983804 join(582618..582789,582884..582987,583043..583114,583174..584244) I 1 NT_166525.1 Catalytic activity: acetyl-CoA + dihydrolipoamide <=> CoA + S-acetyldihydrolipoamide.; Cofactor: lipoyl group.; Complex: component of multienzyme pyruvate dehydrogenase complex.; Function: the branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2).; Title: strong similarity to branched-chain alpha-keto acid dihydrolipoyl acyltransferase - Gallus gallus; localisation:mitochondrion; See PMID 11168412; uncharacterized protein 584244 4983804 An09g02710 Aspergillus niger uncharacterized protein XP_001393585.1 582618 D 5061 CDS An09g02720 4983805 complement(585433..586935) I 1 NT_166525.1 Remark: STR1 (suppressor of telomeric repression-1) is a telomerase-associated protein found in conjunction with S. cerevisiae telomerase, a ribonucleoprotein required for telomere replication.; Title: strong similarity to STR1 protein from patent WO9612811-A2 - Saccharomyces cerevisiae; uncharacterized protein 586935 4983805 An09g02720 Aspergillus niger uncharacterized protein XP_001393586.1 585433 R 5061 CDS An09g02730 4983806 join(587563..588017,588085..588457) I 1 NT_166525.1 Complex: heterodimer of two subunits (IMP1 and IMP2).; Function: Known to process the nuclear encoded CYT-B2, the mitochondrially encoded COX2 and cyctochrome C1.; Function: Required for the stability of IMP1.; Function: catalyzes the removal of signal peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space.; Title: strong similarity to inner membrane protease I chain 2 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8132591; See PMID 8266095; uncharacterized protein 588457 4983806 An09g02730 Aspergillus niger uncharacterized protein XP_001393587.1 587563 D 5061 CDS An09g02740 4983807 complement(join(588608..589159,589213..591780,591834..591914)) I 1 NT_166525.1 Title: strong similarity to hypothetical protein SPAC26H5.11 - Schizosaccharomyces pombe; uncharacterized protein 591914 4983807 An09g02740 Aspergillus niger uncharacterized protein XP_001393588.1 588608 R 5061 CDS An09g02750 84591989 complement(join(592359..592544,592598..592783)) I 1 NT_166525.1 hypothetical protein 592783 84591989 An09g02750 Aspergillus niger hypothetical protein XP_059601351.1 592359 R 5061 CDS An09g02760 84591990 join(593547..594300,594391..594465,594573..594799) I 1 NT_166525.1 hypothetical protein 594799 84591990 An09g02760 Aspergillus niger hypothetical protein XP_059601352.1 593547 D 5061 CDS An09g02770 4983810 complement(join(594809..594887,594960..597799)) I 1 NT_166525.1 Remark: protein is essential for the formation of gamma tubulin ring complex.; Title: similarity to gamma tubulin ring protein GRIP210 - Xenopus laevis; See PMID 11134080; uncharacterized protein 597799 4983810 An09g02770 Aspergillus niger uncharacterized protein XP_001393591.3 594809 R 5061 CDS An09g02780 4983811 complement(join(598762..601986,602133..602144)) I 1 NT_166525.1 Title: similarity to myosin heavy chain - Gallus gallus; See PMID 2892941; See PMID 3312184; See PMID 194651; uncharacterized protein 602144 4983811 An09g02780 Aspergillus niger uncharacterized protein XP_001393592.3 598762 R 5061 CDS An09g02790 4983812 complement(join(602758..604210,604252..604370)) I 1 NT_166525.1 Catalytic activity: TRI101 of F. sporotrichioides catalyzes O-acetylation of the trichothecene ring specifically at the C-3 position in an acetyl-CoA-dependent manner.; Function: TRI101 of F. sporotrichioides converts isotrichodermol to isotrichodermin and is required for the biosynthesis of T-2 toxin.; Function: transfection of TRI101 of F. sporotrichioides into S. cerevisiae, protects the cell from the trichothecene 4,15-diacetoxyscirpenol. Antibiotic-producing organisms, including fungi, protect themselves from their own toxins by e. g. metabolic alteration of the compound.; Remark: trichothecenes like T-2 toxin or 4,15-diacetoxyscirpenol are sesquiterpenoid mycotoxins. They act as potent protein synthesis inhibitors for eukaryotic organisms, and are produced by different fungal genera,including Fusarium.; Title: similarity to trichothecene 3-O-acetyltransferase TRI101 - Fusarium sporotrichioides; See PMID 10583973; See PMID 10960733; uncharacterized protein 604370 4983812 An09g02790 Aspergillus niger uncharacterized protein XP_001393593.3 602758 R 5061 CDS An09g02800 4983813 complement(join(605482..608423,608566..609071,609102..609411,609691..611272)) I 1 NT_166525.1 Catalytic activity: Acetyl-CoA + L-homoserine <=> CoA + O-acetyl-L-homoserine.; Remark: the A. nidulans cysA gene shows extensive similarity to bacterial homoserine O:-acetyltransferases.; Title: strong similarity to serine O-acetyltransferase cysA - Aspergillus nidulans; plasma membrane; See PMID 11021945; uncharacterized protein 611272 4983813 An09g02800 Aspergillus niger uncharacterized protein XP_059601353.1 605482 R 5061 CDS An09g02810 4983814 complement(join(611717..612877,612933..613223,613287..613328)) I 1 NT_166525.1 Title: weak similarity to nuclear mitotic apparatus protein NuMA - Homo sapiens; See PMID 541636; See PMID 1541630; uncharacterized protein 613328 4983814 An09g02810 Aspergillus niger uncharacterized protein XP_001393595.3 611717 R 5061 CDS An09g02820 4983815 join(613704..614255,614414..614617,614670..615003,615055..616799) I 1 NT_166525.1 Function: the RAD4 gene product of S. cerevisiae is required for the incision step of excision repair of DNA damaged by UV and by other agents that distort the DNA helix.; Title: strong similarity to excision repair protein Rad4 - Saccharomyces cerevisiae; nucleus; See PMID 2649477; See PMID 2822652; See PMID 3073107; uncharacterized protein 616799 4983815 An09g02820 Aspergillus niger uncharacterized protein XP_001393596.1 613704 D 5061 CDS An09g02830 4983816 join(617794..617822,617891..618160,618212..620165) I 1 NT_166525.1 Catalytic activity: Acylaminoacyl-peptide + H(2)O = acylamino acid + peptide.; Function: the A. fumigatus homolog DPPV is a secreted dipeptidyl-peptidase.; Title: strong similarity to acylaminoacyl-peptidase DPP V - Aspergillus fumigatus; extracellular/secretion proteins; See PMID 9045640; See PMID 9234752; uncharacterized protein 620165 4983816 An09g02830 Aspergillus niger uncharacterized protein XP_001393597.1 617794 D 5061 CDS An09g02840 4983817 join(620770..621172,621262..621677) I 1 NT_166525.1 Title: strong similarity to hypothetical protein EAA65458.1 - Aspergillus nidulans; uncharacterized protein 621677 4983817 An09g02840 Aspergillus niger uncharacterized protein XP_001393598.1 620770 D 5061 CDS An09g02850 84591991 complement(622596..623243) I 1 NT_166525.1 Similarity: similarities correspond to multiple asparagine and proline repeats.; Title: weak similarity to hypothetical sporozoite surface protein 2 - Plasmodium yoelii; uncharacterized protein 623243 84591991 An09g02850 Aspergillus niger uncharacterized protein XP_059601354.1 622596 R 5061 CDS An09g02860 4983819 complement(join(624042..624505,624585..624591,624655..624816,624965..625048)) I 1 NT_166525.1 Title: weak similarity to DNA topoisomerase top1 -Cricetulus griseus; See PMID 8244980; See PMID 1312902; uncharacterized protein 625048 4983819 An09g02860 Aspergillus niger uncharacterized protein XP_001393600.3 624042 R 5061 CDS An09g02870 4983820 join(625827..626540,626619..626761,626815..627249,627294..628188,628322..628327) I 1 NT_166525.1 Function: the prnA gene of A. nidulans codes for a transcriptional activator that mediates proline induction of four other genes involved in proline utilization as a nitrogen and/or carbon source.; Title: similarity to transcription activator prnA -Aspergillus nidulans; nucleus; See PMID 2668692; See PMID 9622360; See PMID 10788322; uncharacterized protein 628327 4983820 An09g02870 Aspergillus niger uncharacterized protein XP_059601355.1 625827 D 5061 CDS An09g02880 4983821 join(629019..630285,630340..630485) I 1 NT_166525.1 Title: strong similarity to hypothetical protein SPAC922.05c - Schizosaccharomyces pombe; uncharacterized protein 630485 4983821 An09g02880 Aspergillus niger uncharacterized protein XP_001393602.1 629019 D 5061 CDS An09g02890 4983822 join(631003..631919,632031..632334) I 1 NT_166525.1 Title: similarity to hypothetical protein orf-223 -Lactobacillus helveticus; uncharacterized protein 632334 4983822 An09g02890 Aspergillus niger uncharacterized protein XP_001393603.1 631003 D 5061 CDS An09g02900 4983823 complement(632893..635319) I 1 NT_166525.1 Function: the VRP1 gene product of S. cerevisiae acts in both actomyosin ring formation and function as well as in Hof1p localization during cytokinesis.; Remark: the VRP1 gene product of S. cerevisiae binds an SH3-domain-containing fragment of Hof1p, which encodes a protein related to mammalian proline serine threonine phosphatase-interacting protein and S. pombe Cdc15p required for an actomyosin ring-independent pathway of cytokinesis in S. cerevisiae.; Title: similarity to verprolin Vrp1 - Saccharomyces cerevisiae; See PMID 7968536; See PMID 10931290; See PMID 11260524; uncharacterized protein 635319 4983823 An09g02900 Aspergillus niger uncharacterized protein XP_001393604.1 632893 R 5061 CDS An09g02910 4983824 complement(join(636540..637310,637500..638966)) I 1 NT_166525.1 Induction: the S. cerevisiae ATR1 transcription is induced by aminotriazole, and the ATR1 promoter region contains a binding site for the GCN4 activator protein.; Title: similarity to aminotriazole resistance protein Atr1 - Saccharomyces cerevisiae; plasma membrane; See PMID 3280970; See PMID 2123132; uncharacterized protein 638966 4983824 An09g02910 Aspergillus niger uncharacterized protein XP_001393605.3 636540 R 5061 CDS An09g02920 4983825 join(643302..643417,643475..644170,644232..644361,644746..644949) I 1 NT_166525.1 Title: similarity to hypothetical protein 260 -Methanothermus fervidus; uncharacterized protein 644949 4983825 An09g02920 Aspergillus niger uncharacterized protein XP_001393606.3 643302 D 5061 CDS An09g02930 4983826 complement(join(645332..646172,646234..646774,646845..646952,647018..647111)) I 1 NT_166525.1 Title: strong similarity to high-affinity glucose transporter HGT1 - Kluyveromyces lactis; plasma membrane; See PMID 8830679; uncharacterized protein 647111 4983826 An09g02930 Aspergillus niger uncharacterized protein XP_001393607.1 645332 R 5061 CDS An09g02940 84591992 complement(join(647671..647711,647887..647940,648034..648129,648287..648506)) I 1 NT_166525.1 hypothetical protein 648506 84591992 An09g02940 Aspergillus niger hypothetical protein XP_059601356.1 647671 R 5061 CDS An09g02943 84591993 complement(649858..650112) I 1 NT_166525.1 hypothetical protein 650112 84591993 An09g02943 Aspergillus niger hypothetical protein XP_059601357.1 649858 R 5061 CDS An09g02945 84591994 complement(join(651461..651668,651735..651853,651907..651951)) I 1 NT_166525.1 hypothetical protein 651951 84591994 An09g02945 Aspergillus niger hypothetical protein XP_059601358.1 651461 R 5061 CDS An09g02950 4983830 complement(join(656608..657960,658027..658098)) I 1 NT_166525.1 hypothetical protein 658098 4983830 An09g02950 Aspergillus niger hypothetical protein XP_001393611.3 656608 R 5061 CDS An09g02960 4983831 join(658318..658552,658691..659702,659754..661476) I 1 NT_166525.1 Title: similarity to hypothetical protein B24P7.50 -Neurospora crassa; uncharacterized protein 661476 4983831 An09g02960 Aspergillus niger uncharacterized protein XP_059601359.1 658318 D 5061 CDS An09g02970 84591995 complement(join(662230..662263,662335..662465)) I 1 NT_166525.1 Title: questionable ORF; uncharacterized protein 662465 84591995 An09g02970 Aspergillus niger uncharacterized protein XP_059601360.1 662230 R 5061 CDS An09g02980 4983833 join(663980..664248,664312..664434,664498..665203) I 1 NT_166525.1 Catalytic activity: 2 catechol + O(2) = 2 1,2-benzoquinone + 2 H(2)O.; Remark: patentmatch against polyphenol oxidase PPO W09421 Geneseqprot.; Title: similarity to polyphenol oxidase PPO from patent WO9637617-A1 - Lactuca sativa; uncharacterized protein 665203 4983833 An09g02980 Aspergillus niger uncharacterized protein XP_059601361.1 663980 D 5061 CDS An09g02990 4983834 complement(join(665273..666039,666350..666482,666638..666799)) I 1 NT_166525.1 Title: similarity to hypothetical Sua5 protein APE2397 - Aeropyrum pernix; uncharacterized protein 666799 4983834 An09g02990 Aspergillus niger uncharacterized protein XP_001393615.3 665273 R 5061 CDS An09g03000 4983835 join(669619..669842,669921..670446) I 1 NT_166525.1 Title: weak similarity to hypothetical plenty-of-prolines-101 protein POP101 - Mus musculus; uncharacterized protein 670446 4983835 An09g03000 Aspergillus niger uncharacterized protein XP_001393616.1 669619 D 5061 CDS An09g03010 4983836 complement(join(671532..671594,671763..672164)) I 1 NT_166525.1 Remark: The EST sequence is from Aspergillus niger but deviates in several positions from the sequence of the genomic DNA.; Title: strong similarity to EST an_2241 -Aspergillus niger; uncharacterized protein 672164 4983836 An09g03010 Aspergillus niger uncharacterized protein XP_059601362.1 671532 R 5061 CDS An09g03020 4983837 join(673971..674067,674190..674938) I 1 NT_166525.1 Function: the Aspergillus nidulans complex locus,cnxABC, has been shown to be required for the synthesis of precursor Z, an intermediate in the molybdopterin cofactor pathway.; Induction: transcription of the cnxABC locus is subject to nitrate induction.; Remark: cnxABC is a difunctional protein with two catalytic domains, CnxA and CnxC.; Remark: the molybdopterin cofactor is required for the activity of the molybdoenzyme nitrate reductase.; Similarity: the CnxA domain is similar at the amino acid level to the Escherichia coli moaA gene product, while CnxC is similar to the E. coli moaC product, with both E. coli products encoded by different cistrons.; Title: similarity to molybdopterin cofactor biosynthetic protein cnxABC - Aspergillus nidulans; See PMID 9353296; uncharacterized protein 674938 4983837 An09g03020 Aspergillus niger uncharacterized protein XP_001393618.1 673971 D 5061 CDS An09g03030 4983838 complement(join(675020..676268,676393..676694)) I 1 NT_166525.1 Catalytic activity: ATP + gamma-L-glutamyl-L-cysteine + glycine <=> ADP + phosphate + glutathione.; Pathway: GSH2 catalyzes the second step in glutathione biosynthesis.; Remark: Glutathione (GSH) is important for the detoxification of harmful intermediates that are generated during normal cellular metabolism.; Title: strong similarity to glutathione synthase Gsh2 - Saccharomyces cerevisiae [putative sequencing error]; putative sequencing error; See PMID 9307967; See PMID 9512666; uncharacterized protein 676694 4983838 An09g03030 Aspergillus niger uncharacterized protein XP_001393619.1 675020 R 5061 CDS An09g03040 4983839 join(677274..677311,677443..679090) I 1 NT_166525.1 Title: weak similarity to hypothetical protein CAE76587.1 - Neurospora crassa; uncharacterized protein 679090 4983839 An09g03040 Aspergillus niger uncharacterized protein XP_001393620.3 677274 D 5061 CDS An09g03050 4983840 join(680391..680501,680654..680758,680875..682405,682500..682592,683006..683415,683460..685259,685322..685432,685501..685589,685692..685863) I 1 NT_166525.1 Title: similarity to hypothetical protein SCF91.02c - Streptomyces coelicolor; uncharacterized protein 685863 4983840 An09g03050 Aspergillus niger uncharacterized protein XP_059601363.1 680391 D 5061 CDS An09g03060 10098215 join(686492..686510,687038..687666) I 1 NT_166525.1 Catalytic activity: H(2)CO(3) = CO(2) + H(2)O.; Function: carbonic anhydrase beta-CA1 catalyzes the reversible hydration of CO2, a reaction that is important in many physiological processes.; Title: strong similarity to beta-type carbonic anhydrase beta-CA1 - Coccomyxa sp.; See PMID 9701590; uncharacterized protein 687666 10098215 An09g03060 Aspergillus niger uncharacterized protein XP_003188793.2 686492 D 5061 CDS An09g03070 4983842 complement(join(688283..688306,688383..688415,688823..689331,689391..689596,689678..695653,695715..695890,695944..696300)) I 1 NT_166525.1 Function: mok1 plays an essential role for cell morphogenesis.; Induction: alpha-glucan biosynthesis is regulated in a signaling pathway in which the Rho2p GTPase activates Pck2p, and this kinase in turn controls mok1.; Localization: mok1 localizes closely with the actin cytoskeleton.; Localization: the myosin Myo52 partially colocalises with the alpha-glucan synthase mok1 at the cell tips and to a lesser extent at the septum.; Title: strong similarity to alpha-glucan synthase mok1p - Schizosaccharomyces pombe; See PMID 11102532; See PMID 11112691; uncharacterized protein 696300 4983842 An09g03070 Aspergillus niger uncharacterized protein XP_001393623.3 688283 R 5061 CDS An09g03080 84591996 join(697277..697349,697490..697935) I 1 NT_166525.1 hypothetical protein 697935 84591996 An09g03080 Aspergillus niger hypothetical protein XP_059601364.1 697277 D 5061 CDS An09g03090 84591997 complement(join(699514..699730,699812..699843,699952..700093,700181..700362,700564..700653,700695..700886)) I 1 NT_166525.1 Remark: similarity is due to glutamate-rich region of the protein.; Title: weak similarity to retinitis pigmentosa GTPase regulator RPGR - Homo sapiens; uncharacterized protein 700886 84591997 An09g03090 Aspergillus niger uncharacterized protein XP_059601365.1 699514 R 5061 CDS An09g03100 4983845 join(701095..702105,702163..702819) I 1 NT_166525.1 Catalytic activity: AmyA catalyzes the hydrolysis of internal 1,4-alpha-D-glucosidic bonds in oligosaccharides and polysaccharides.; Remark: AmyA requires for its activity the binding of the cofactor calcium.; Title: strong similarity to alpha-amylase precursor amy - Aspergillus niger; extracellular/secretion proteins; See PMID 2340591; uncharacterized protein 702819 4983845 An09g03100 Aspergillus niger uncharacterized protein XP_003188777.1 701095 D 5061 CDS An09g03110 4983846 join(703518..703596,703675..704082,704171..704586,704637..704825,704924..704944,705002..705221,705270..705531,705634..705667) I 1 NT_166525.1 Catalytic activity: AMY catalyzes the hydrolysis of internal 1,4-alpha-D-glucosidic bonds in oligosaccharides and polysaccharides.; Remark: Bacillus amyloliquefaciens alpha-amylase AMY is commercially supplied as 'Bacillus subtilis alpha-amylase'.; Title: strong similarity to alpha-amylase precursor amy - Bacillus amyloliquefaciens; extracellular/secretion proteins; See PMID 2830166; See PMID 6156671; uncharacterized protein 705667 4983846 An09g03110 Aspergillus niger uncharacterized protein XP_059601366.1 703518 D 5061 CDS An09g03120 4983847 complement(join(706289..706505,706716..706872,707020..707204,707277..707411,707479..707557,707624..707675)) I 1 NT_166525.1 Title: similarity to hypothetical serine-rich protein - Schizosaccharomyces pombe; uncharacterized protein 707675 4983847 An09g03120 Aspergillus niger uncharacterized protein XP_059601367.1 706289 R 5061 CDS An09g03130 4983848 complement(join(709618..711317,711370..711682,711742..711975)) I 1 NT_166525.1 Catalytic activity: 2 H(2)O(2) = O(2) + 2 H(2)O.; Function: catalase occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.; Induction: catA mRNA is barely detectable in growing mycelia, highly induced during sporulation, and present in isolated spores.; Phenotype: catA-disrupted mutants produced spores were sensitive to H2O2, as compared to wild-type spores.; Remark: catA has heme as a cofactor.; Remark: catA is the major spore catalase.; Title: strong similarity to catalase A catA -Aspergillus nidulans; See PMID 8598056; uncharacterized protein 711975 4983848 An09g03130 Aspergillus niger uncharacterized protein XP_001393629.1 709618 R 5061 CDS An09g03140 4983849 join(713099..713731,713799..713837,713979..714243,714659..714666,714768..715058) I 1 NT_166525.1 Catalytic activity: An alcohol + NAD(+) = an aldehyde or ketone + NADH.; Remark: adhB was identified as a major stress protein and is induced both by exposure to ethanol and by elevated temperature (45 degrees C).; Title: similarity to alcohol dehydrogenase II adhB -Zymomonas mobilis; See PMID 1917831; See PMID 2059047; uncharacterized protein 715058 4983849 An09g03140 Aspergillus niger uncharacterized protein XP_059601368.1 713099 D 5061 CDS An09g03150 84591998 complement(join(715939..716152,716232..716311,716421..716496,716542..716631,716711..716797,716890..716942)) I 1 NT_166525.1 Title: weak similarity to cell differentiating factor BUF-3 from patent JP02009388-A - Homo sapiens; uncharacterized protein 716942 84591998 An09g03150 Aspergillus niger uncharacterized protein XP_059601369.1 715939 R 5061 CDS An09g03160 4983851 join(716966..717248,717356..720249,720331..720560,720622..721480) I 1 NT_166525.1 Function: DRS2 encodes an aminophospholipid-transporting ATPase.; Function: DRS2 has a possible role in late Golgi function.; Golgi; Localization: DRS2 localizes to late Golgi membranes.; Similarity: DRS2 has similarity to membrane-spanning Ca2+ ATPases.; Similarity: DRS2 is a member of the cation transporting (E1-E2) P-type ATPase superfamily.; Title: strong similarity to ATPase Drs2 -Saccharomyces cerevisiae; See PMID 8247005; See PMID 10601336; uncharacterized protein 721480 4983851 An09g03160 Aspergillus niger uncharacterized protein XP_059601370.1 716966 D 5061 CDS An09g03170 4983852 complement(join(722143..722676,722984..723050,723107..723221,723288..723942,724013..724137,724304..724382)) I 1 NT_166525.1 Phenotype: disruption of TRI12 of F. sporotrichioides results in both reduced growth on complex media and reduced levels of trichothecene production.; Remark: growth of TRI12 mutants on trichothecene-containing media is inhibited, suggesting that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.; Remark: trichothecenes are sesquiterpenoid mycotoxins and act as protein synthesis inhibitors for eukaryotic organisms.; Similarity: the ORF encoded protein and TRI12 from F. sporotrichioides show similarities to members of the major facilitator superfamily (MFS) of transporters.; Title: strong similarity to trichothecene efflux pump TRI12 - Fusarium sporotrichioides; plasma membrane; See PMID 10485289; uncharacterized protein 724382 4983852 An09g03170 Aspergillus niger uncharacterized protein XP_059601371.1 722143 R 5061 CDS An09g03180 4983853 join(725541..725905,725967..726028,726096..726427,726525..726620) I 1 NT_166525.1 Function: Pth11 from M. grisea is involved in surface dependent signal transduction during plant infection. Pth11 can activate appressorium differentiation in response to inductive surface cues and repress differentiation on poorly inductive surfaces.; Remark: the filamentous ascomycete Magnaporthe grisea is the blast pathogen of many grass species,including rice.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529; uncharacterized protein 726620 4983853 An09g03180 Aspergillus niger uncharacterized protein XP_001393634.3 725541 D 5061 CDS An09g03190 84591999 complement(join(727140..727508,727556..727666)) I 1 NT_166525.1 hypothetical protein 727666 84591999 An09g03190 Aspergillus niger hypothetical protein XP_059601372.1 727140 R 5061 CDS An09g03200 4983855 join(728299..728599,728679..728806,728887..729069,729132..729716) I 1 NT_166525.1 Title: strong similarity to protein SEQ ID NO:4585 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 729716 4983855 An09g03200 Aspergillus niger uncharacterized protein XP_001393636.1 728299 D 5061 CDS An09g03210 4983856 complement(join(730537..730668,730731..731601,731668..731792,731853..732040,732111..732342)) I 1 NT_166525.1 Catalytic activity: Benzoate + NADPH + O(2) <=> 4-hydroxybenzoate + NADP(+) + H(2)O.; Cofactor: Heme.; Function: the P450rm-monooxygenase system in microsomes of R. minuta might function in the degradation of L-phenylalanine on the pathway to beta-ketoadipate.; Remark: the P450rm gene product from Rhodotorula minuta acts as a bifunctional enzyme with isobutene-forming and benzoate 4-hydroxylase activities.; Title: strong similarity to isobutene-forming enzyme and benzoate 4-hydroxylase P450rm - Rhodotorula minuta; See PMID 7764227; See PMID 8002981; See PMID 8882724; See PMID 9349702; uncharacterized protein 732342 4983856 An09g03210 Aspergillus niger uncharacterized protein XP_001393637.1 730537 R 5061 CDS An09g03220 84592000 complement(join(733556..733713,733773..733856,733944..733977,734103..734232,734303..734507,734609..734642)) I 1 NT_166525.1 Title: weak similarity to hypothetical protein BAA90383.1 - Oryza sativa; uncharacterized protein 734642 84592000 An09g03220 Aspergillus niger uncharacterized protein XP_059601373.1 733556 R 5061 CDS An09g03230 4983858 join(735347..735473,735543..735562,735613..735649,735702..735769,735823..736193,736252..736738) I 1 NT_166525.1 Function: Pth11 from M. grisea is involved in surface dependent signal transduction during plant infection. Pth11 can activate appressorium differentiation in response to inductive surface cues and repress differentiation on poorly inductive surfaces.; Remark: the filamentous ascomycete Magnaporthe grisea is the blast pathogen of many grass species,including rice.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529; uncharacterized protein 736738 4983858 An09g03230 Aspergillus niger uncharacterized protein XP_001393639.1 735347 D 5061 CDS An09g03240 4983859 join(738551..738647,738744..739888) I 1 NT_166525.1 Catalytic activity: (R)-mevalonate + CoA + 2 NADP(+) <=> (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH .; Title: strong similarity to 3-hydroxy-3-methylglutaryl coenzyme A reductase HmgA -Sulfolobus solfataricus; See PMID 9171410; uncharacterized protein 739888 4983859 An09g03240 Aspergillus niger uncharacterized protein XP_001393640.3 738551 D 5061 CDS An09g03250 84592001 join(740184..740259,740357..740407,740491..742331) I 1 NT_166525.1 Function: the human SN2 transporter mediates Na(+)-coupled transport of system N-specific amino acid substrates (glutamine, asparagine, and histidine). In addition, SN2 also transports serine, alanine, and glycine.; Remark: SN2 is an amino acid transport system N cloned from human a liver cell line.; Similarity: the ORF encoded protein shows also similarity to the Arabidopsis thaliana protein fragment SEQ ID NO: 51488 from patent EP1033405-A2, but its function is not decribed.; Title: similarity to amino acid transport system SN2 - Homo sapiens; plasma membrane; See PMID 11243884; uncharacterized protein 742331 84592001 An09g03250 Aspergillus niger uncharacterized protein XP_059601374.1 740184 D 5061 CDS An09g03260 4983861 complement(join(743249..743530,743591..744044,744102..744247,744306..744614,744668..744964)) I 1 NT_166525.1 Catalytic activity: Polygalacturonases random hydrolyse 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans.; Function: the endo-polygalacturonase D pgaD is the only A. niger PG capable of hydrolyzing di-galacturonate.; Gene-ID: pgaD; Mapping: pgaD from A. niger is mapped to chromosome I; see EMBL Y18806.; Remark: pgaD = PGD.; See PMID 10675564; endo-polygalacturonase D pgaD-Aspergillus niger 744964 pgaD 4983861 pgaD Aspergillus niger endo-polygalacturonase D pgaD-Aspergillus niger XP_059601375.1 743249 R 5061 CDS An09g03265 84592002 746814..747095 I 1 NT_166525.1 hypothetical protein 747095 84592002 An09g03265 Aspergillus niger hypothetical protein XP_059601376.1 746814 D 5061 CDS An09g03270 4983863 join(747640..747793,747850..748071,748154..748599) I 1 NT_166525.1 Remark: RTM1 overexpression in S. cerevisiae confers resistance to molasses. Its molecular function is unknown.; Title: strong similarity to hypothetical molasses resistency protein Rtm1 - Saccharomyces cerevisiae; See PMID 7672593; uncharacterized protein 748599 4983863 An09g03270 Aspergillus niger uncharacterized protein XP_059601377.1 747640 D 5061 CDS An09g03280 84592003 join(749081..749228,749284..749547,749650..750209) I 1 NT_166525.1 Remark: RTA1 overexpression in S. cerevisiae confers resistance to 7-aminocholesterol. Its molecular function is unknown.; Remark: alternate name for S. cerevisiae Rta1: YGR213C.; Title: strong similarity to hypothetical 7-aminocholesterol resistance protein Rta1 - Saccharomyces cerevisiae; See PMID 8660468; uncharacterized protein 750209 84592003 An09g03280 Aspergillus niger uncharacterized protein XP_059601378.1 749081 D 5061 CDS An09g03290 4983865 complement(750425..751558) I 1 NT_166525.1 Function: the qa-4 gene of Neurospora crassa encodes 3-dehydroshikimate dehydratase, which catalyzes the third step of the quinic acid (qa) catabolic pathway.; Pathway: in Neurospora crassa, five structural genes and two regulatory genes control the use of quinic acid as a carbon source.; Title: strong similarity to 3-dehydroshikimate dehydratase qa-4 - Neurospora crassa; See PMID 6241580; uncharacterized protein 751558 4983865 An09g03290 Aspergillus niger uncharacterized protein XP_001393646.1 750425 R 5061 CDS An09g03300 4983866 753351..755561 I 1 NT_166525.1 Catalytic activity: the purified XylS enzyme from Sulfolobus solfataricus shows high hydrolytic activity on the disaccharide isoprimeverose and catalyzing the release of xylose from xyloglucan oligosaccharides.; Similarity: the xylS (Sulfolobus solfataricus) gene encodes a monomeric enzyme homologous to alpha-glucosidases, alpha-xylosidases, glucoamylases and sucrase-isomaltases of the glycosyl hydrolase family 31.; Title: strong similarity to alpha-xylosidase XylS -Sulfolobus solfataricus; See PMID 10801892; uncharacterized protein 755561 4983866 An09g03300 Aspergillus niger uncharacterized protein XP_001393647.1 753351 D 5061 CDS An09g03310 4983867 complement(join(756045..756353,756390..756857,756913..757032)) I 1 NT_166525.1 Title: strong similarity to hypothetical protein encoded by An02g05790 - Aspergillus niger; uncharacterized protein 757032 4983867 An09g03310 Aspergillus niger uncharacterized protein XP_059601379.1 756045 R 5061 CDS An09g03320 4983868 complement(join(758201..758453,758520..758651,758716..759702,759766..760091)) I 1 NT_166525.1 Remark: the Flu1 gene product from C. albicans complements the fluconazole hypersusceptibility of a S. cerevisiae pdr5 mutant, lacking the ABC (ATP-binding cassette) transporter gene PDR5.; Similarity: the predicted ORF shows strong similarity to known and hypothetical members of he multidrug efflux transporters belonging to the major facilitator superfamily of transport proteins.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353; uncharacterized protein 760091 4983868 An09g03320 Aspergillus niger uncharacterized protein XP_001393649.1 758201 R 5061 CDS An09g03330 4983869 join(761546..761679,761738..761940,762077..762153) I 1 NT_166525.1 Title: similarity to hypothetical protein encoded by SCE66.10c - Streptomyces coelicolor; uncharacterized protein 762153 4983869 An09g03330 Aspergillus niger uncharacterized protein XP_001393650.1 761546 D 5061 CDS An09g03340 4983870 join(762851..762954,763058..763287,763336..763647,763715..764238,764287..764608,764681..764823,764895..765086) I 1 NT_166525.1 Remark: Botryotinia fuckeliana=Botrytis cinerea.; Similarity: the Bcmfs1 protein from Botryotinia fuckeliana belongs to the major facilitator family of transporters.; Title: strong similarity to MFS drug transporter Bcmfs1 - Botryotinia fuckeliana; plasma membrane; See PMID 11374155; uncharacterized protein 765086 4983870 An09g03340 Aspergillus niger uncharacterized protein XP_001393651.3 762851 D 5061 CDS An09g03350 4983871 join(766146..766746,766809..767148,767208..767482,767545..767787,767870..767970) I 1 NT_166525.1 Title: strong similarity to fumonisin permease SEQ ID NO:7 from patent WO200105980-A1 - Exophiala spinifera; plasma membrane; uncharacterized protein 767970 4983871 An09g03350 Aspergillus niger uncharacterized protein XP_059601380.1 766146 D 5061 CDS An09g03360 84592004 join(770456..770578,770662..770757,770815..770904) I 1 NT_166525.1 hypothetical protein 770904 84592004 An09g03360 Aspergillus niger hypothetical protein XP_059601381.1 770456 D 5061 CDS An09g03370 4983873 complement(join(773485..773559,773627..773688,773745..773818,774045..774107,774257..774405,774546..774569)) I 1 NT_166525.1 Title: weak similarity to hypothetical protein encoded by F16G20.170 - Arabidopsis thaliana; uncharacterized protein 774569 4983873 An09g03370 Aspergillus niger uncharacterized protein XP_059601382.1 773485 R 5061 CDS An09g03380 4983874 complement(join(776025..777695,777837..778142)) I 1 NT_166525.1 Similarity: the similarities of the ORF encoded protein to all matching proteins with lower scores are based on repetitive structures.; Title: similarity to hypothetical protein B24P7.110 - Neurospora crassa; uncharacterized protein 778142 4983874 An09g03380 Aspergillus niger uncharacterized protein XP_001393655.3 776025 R 5061 CDS An09g03390 84592005 join(779313..779328,779407..779507) I 1 NT_166525.1 Title: questionable ORF; uncharacterized protein 779507 84592005 An09g03390 Aspergillus niger uncharacterized protein XP_059601383.1 779313 D 5061 CDS An09g03400 84592006 complement(join(779620..779705,779774..779954,780039..780233,780302..780376,780458..780493)) I 1 NT_166525.1 hypothetical protein 780493 84592006 An09g03400 Aspergillus niger hypothetical protein XP_059601384.1 779620 R 5061 CDS An09g03410 84592007 complement(join(781871..782067,782123..782221,782278..782443)) I 1 NT_166525.1 hypothetical protein 782443 84592007 An09g03410 Aspergillus niger hypothetical protein XP_059601385.1 781871 R 5061 CDS An09g03420 84592008 join(783655..783735,783848..783973) I 1 NT_166525.1 Title: questionable ORF; uncharacterized protein 783973 84592008 An09g03420 Aspergillus niger uncharacterized protein XP_059601386.1 783655 D 5061 CDS An09g03430 84592009 complement(join(784537..784791,784883..784925,785023..785211,785252..785278,785379..785693,785933..786018,786073..786242,786342..786588,786669..786770)) I 1 NT_166525.1 Title: strong similarity to EST an_1400 -Aspergillus niger; uncharacterized protein 786770 84592009 An09g03430 Aspergillus niger uncharacterized protein XP_059601387.1 784537 R 5061 CDS An09g03440 4983880 join(787922..788137,788240..788989) I 1 NT_166525.1 Similarity: the ORF DNA sequence shows strong similarity to the EST an_3606 from Aspergillus niger.; Similarity: the similarity to CipA from Clostridium thermocellum is located in an highly repetetive sequence domain of CipA.; Title: similarity to S-layer protein CipA -Clostridium thermocellum; See PMID 8458832; uncharacterized protein 788989 4983880 An09g03440 Aspergillus niger uncharacterized protein XP_001393661.1 787922 D 5061 CDS An09g03450 4983881 complement(join(789604..789867,790029..790280,790374..790616)) I 1 NT_166525.1 Catalytic activity: D-ribulose 5-phosphate <=> D-xylulose 5-phosphate.; Phenotype: rpe1 null mutants are viable but show no ribulose-5-phosphate epimerase activity, cannot grow on D-xylulose, and are sensitive to hydrogren peroxide.; Remark: Rpe1 also converts D-erythrose 4-phosphate into D-erythrulose 4-phosphate and D-threose 4-phosphate.; Remark: synonyms for Rpe1 from S. cerevisiae are Epi1, Pos18 and YJL121c.; Title: strong similarity to ribulose-5-phosphate-epimerase Rpe1 - Saccharomyces cerevisiae; cytoplasm; See PMID 8879247; See PMID 8929392; uncharacterized protein 790616 4983881 An09g03450 Aspergillus niger uncharacterized protein XP_001393662.1 789604 R 5061 CDS An09g03460 84592010 complement(join(791621..791939,792010..792014)) I 1 NT_166525.1 hypothetical protein 792014 84592010 An09g03460 Aspergillus niger hypothetical protein XP_059601388.1 791621 R 5061 CDS An09g03470 4983883 join(792273..792987,793207..795233) I 1 NT_166525.1 Similarity: the similarities of the ORF encoded protein to all matching proteins with lower scores are mainly based on repetitive structures.; Title: strong similarity to hypothetical verprolin related protein encoded by B24P7.40 - Neurospora crassa; uncharacterized protein 795233 4983883 An09g03470 Aspergillus niger uncharacterized protein XP_059601389.1 792273 D 5061 CDS An09g03480 4983884 join(795999..796012,796097..796347,796460..796491) I 1 NT_166525.1 Complex: S. cerevisiae Lsm subunits form a heteromer with a dougnut shape.; Function: S. cerevisiae Lsm2 binds specifically to the 3'-terminal U-tract of U6 snRNA.; Remark: synonyms for S. cerevisiae Lsm2 are Smx5,Snp3 and YBL026w.; Similarity: S. cerevisiae Lsm2 belongs to the snRNP SM proteins family.; Title: strong similarity to snRNA-associated sm-like protein Lsm2 - Saccharomyces cerevisiae; nucleus; See PMID 11333229; See PMID 10747033; uncharacterized protein 796491 4983884 An09g03480 Aspergillus niger uncharacterized protein XP_001393665.1 795999 D 5061 CDS An09g03490 4983885 join(797436..798332,798383..799287,799378..800005) I 1 NT_166525.1 Function: Mus musculus SNM1 is involved in DNA interstrand cross-links (ICLs) repair.; Remark: Mus musculus SNM1 is the mammalian homolog of the S. cerevisiae gene SNM1 (PSO2).; Title: strong similarity to protein involved in DNA repair SNM1 - Mus musculus; nucleus; See PMID 10848582; uncharacterized protein 800005 4983885 An09g03490 Aspergillus niger uncharacterized protein XP_059601390.1 797436 D 5061 CDS An09g03500 4983886 join(800821..801119,801200..802454) I 1 NT_166525.1 Catalytic activity: Benzoate + NADPH + O(2) <=> 4-hydroxybenzoate + NADP(+) + H(2)O.; Cofactor: iron; tetrahydropteridine.; Function: oxidoreductase acting on paired donors with incorporation of molecular oxygen with NADH or NADPH as one donor, and incorporation of one atom of oxygen; Gene-ID: bphA; Induction: bphA of A. niger is inducible by benzoate.; Mapping: bphA from A. niger is mapped to chromosome I; see list from DSM, EMBL X52521.; Pathway: bphA of A. niger is an enzyme in the phenylalanine metabolism.; Phenotype: A. niger transformant with a multicopy bphA insert do not grow on benzoate, whereas a transformant with only one extra copy could grow.; Remark: bphA of A. niger is a member of a new P450 gene family designated P450LIII.; endoplasmatic reticulum; See PMID 1868576; See PMID 2250647; benzoate 4-monooxygenase cytochrome P450 53 bphA-Aspergillus niger 802454 bphA 4983886 bphA Aspergillus niger benzoate 4-monooxygenase cytochrome P450 53 bphA-Aspergillus niger XP_001393667.1 800821 D 5061 CDS An09g03510 4983887 complement(join(803182..803437,803476..804232,804284..804543,804592..805035,805090..805425,805487..805593,805683..805740,805828..805982)) I 1 NT_166525.1 Function: Leu3p of S. cerevisiae is a dual-function regulator, stimulating transcription when the inducer alpha-isopropylmalate (alpha-IPM) is present and suppressing transcription when the inducer is absent.; Remark: yeast zinc cluster proteins form a major class of yeast transcriptional regulators. they usually bind as homodimers to target DNA sequences, with each monomer recognizing a CGG triplet. orientation and spacing between the CGG triplet specifies the recognition sequence for a given zinc cluster protein. Leu3p of S. cerevisiae also recognizes CGG triplets, but when oriented in opposite direction, an everted repeat.; Similarity: Leu3p of S. cerevisiae belongs to the family of Zn(II)2Cys6 proteins.; Title: strong similarity to leucine-specific regulatory protein Leu3 - Saccharomyces cerevisiae; nucleus; See PMID 8428928; See PMID 8706857; See PMID 9660826; See PMID 10383402; uncharacterized protein 805982 4983887 An09g03510 Aspergillus niger uncharacterized protein XP_059606260.1 803182 R 5061 CDS An09g03520 84592011 join(806987..807094,807226..807297,807354..807525,807723..807823) I 1 NT_166525.1 hypothetical protein 807823 84592011 An09g03520 Aspergillus niger hypothetical protein XP_059606261.1 806987 D 5061 CDS An09g03530 4983889 join(808024..808165,808220..808338,808407..808616,808687..808725) I 1 NT_166525.1 Title: strong similarity to hypothetical protein EAA62175.1 - Aspergillus nidulans; uncharacterized protein 808725 4983889 An09g03530 Aspergillus niger uncharacterized protein XP_001393670.1 808024 D 5061 CDS An09g03540 84592012 809100..809483 I 1 NT_166525.1 hypothetical protein 809483 84592012 An09g03540 Aspergillus niger hypothetical protein XP_059606262.1 809100 D 5061 CDS An09g03550 84592013 join(810000..810056,810152..810307,810438..810644) I 1 NT_166525.1 hypothetical protein 810644 84592013 An09g03550 Aspergillus niger hypothetical protein XP_059606263.1 810000 D 5061 CDS An09g03560 4983892 join(810991..811111,811188..811396,811451..811531) I 1 NT_166525.1 Similarity: the predicted A. niger protein is similar to several conserved microbial hypothetical proteins.; Title: similarity to hypothetical protein CC3092 -Caulobacter crescentus; uncharacterized protein 811531 4983892 An09g03560 Aspergillus niger uncharacterized protein XP_001393673.1 810991 D 5061 CDS An09g03570 84592014 join(812079..812215,812368..812511,812619..812870,813071..813255,813340..813438,813489..813561,813857..814028) I 1 NT_166525.1 Catalytic activity: citA of S. coelicolor catalyses the reaction citrate + CoA = acetyl-CoA + H(2)O + oxaloacetate.; Remark: a citA mutant of S. coelicolor was a glutamate auxotroph, indicating that citA encoded the major citrate synthase allowing flow of acetyl-CoA into the tricarboxylic acid (TCA) cycle. interruption of aerobic TCA cycle-based metabolism resulted in acidification of the medium and defects in morphological differentiation and antibiotic biosynthesis.; Similarity: the predicted A. niger protein is similar to several plant and microbial citrate synthases.; Title: similarity to citrate synthase citA -Streptomyces coelicolor; See PMID 11325948; uncharacterized protein 814028 84592014 An09g03570 Aspergillus niger uncharacterized protein XP_059606264.1 812079 D 5061 CDS An09g03580 84592015 join(814670..814807,814873..814908,814988..815218,815281..815637) I 1 NT_166525.1 Similarity: similarity of the predicted A. niger protein to various protein sequences is due to low complexity sequences.; hypothetical protein 815637 84592015 An09g03580 Aspergillus niger hypothetical protein XP_059606265.1 814670 D 5061 CDS An09g03590 84592016 complement(join(<815720..815843,815884..815952,816039..816126,816292..816400)) I 1 NT_166525.1 hypothetical protein 816400 84592016 An09g03590 Aspergillus niger hypothetical protein XP_059606266.1 815720 R 5061 CDS An09g03600 4983896 join(816712..817192,817249..818279) I 1 NT_166525.1 Function: AflR in A. flavus is required for the expression of the nor1 and ver1 genes.; Pathway: AflR in A. flavus is involved in the regulation of aflatoxin biosynthesis.; Similarity: AflR of A. flavus encodes a putative transcription factor containing a Zn(2)-Cys(6) fungal-type binuclear cluster domain.; Similarity: the homology is limited to the N-terminus containing the Zn(2)-Cys(6) fungal-type binuclear cluster domain.; Title: similarity to aflatoxin biosynthesis regulator aflR - Aspergillus flavus; See PMID 8074521; uncharacterized protein 818279 4983896 An09g03600 Aspergillus niger uncharacterized protein XP_001393677.1 816712 D 5061 CDS An09g03610 84592017 complement(join(818605..818687,818750..818912,819068..819352)) I 1 NT_166525.1 hypothetical protein 819352 84592017 An09g03610 Aspergillus niger hypothetical protein XP_059606267.1 818605 R 5061 CDS An09g03620 4983898 complement(819957..820592) I 1 NT_166525.1 Similarity: the predicted A. niger protein shows similarity to several conserved microbial hypothetical proteins.; Title: similarity to hypothetical protein aq_1250 -Aquifex aeolicus; uncharacterized protein 820592 4983898 An09g03620 Aspergillus niger uncharacterized protein XP_001393679.1 819957 R 5061 CDS An09g03630 4983899 join(821370..821529,821589..821858,821912..823284) I 1 NT_166525.1 Remark: Aut4p of S. cerevisiae is involved in autophagocytosis, a degradative transport pathway that delivers cytosolic proteins to the lysosome (vacuole). aut4-deleted cells show a partial reduction in total protein breakdown during nitrogen starvation.; Remark: a biologically active fusion protein of Aut4p and the green fluorescent protein is visualized at the vacuolar membrane and in punctate structures attached to the vacuole.; Similarity: the predicted A. niger protein is similar to Aut4p of S. cerevisiae which has limited homology to permeases.; Title: strong similarity to hypothetical protein Aut4 - Saccharomyces cerevisiae; intracellular transport vesicles; See PMID 11058089; uncharacterized protein 823284 4983899 An09g03630 Aspergillus niger uncharacterized protein XP_059606268.1 821370 D 5061 CDS An09g03640 4983900 complement(join(823645..823674,823816..824242,824297..824447,824518..825415)) I 1 NT_166525.1 Function: NPL1 of A. thaliana is a light-dependent autophosphorylating serine/threonine protein kinase that mediates the avoidance response of chloroplasts to high-intensity blue light.; Remark: A. thaliana NPL1, like A. thaliana NPH1,noncovalently binds the chromophore flavin mononucleotide (FMN) within two specialized PAS domains, termed LOV domains.; Similarity: the predicted A. niger protein is similar to plant blue light receptors (nonphototropic hypocotyl 1 (NPH1) and NPH-like 1 (NPL1)).; Title: similarity to non phototropic hypocotyl 1-like serine/threonine protein kinase NPL1 - Arabidopsis thaliana; See PMID 11251116; See PMID 11309623; See PMID 11371609; uncharacterized protein 825415 4983900 An09g03640 Aspergillus niger uncharacterized protein XP_059606269.1 823645 R 5061 CDS An09g03650 4983901 complement(join(825921..826325,826394..826654)) I 1 NT_166525.1 Title: weak similarity to hypothetical protein Ta0309 - Thermoplasma acidophilum; uncharacterized protein 826654 4983901 An09g03650 Aspergillus niger uncharacterized protein XP_001393682.1 825921 R 5061 CDS An09g03660 4983902 complement(join(827664..827674,827777..827880,827930..827949,828178..829461)) I 1 NT_166525.1 Function: translocation of neutral aliphatic and aromatic amino acids across the plasma membrane of the ascomycete Neurospora crassa requires a functional gene product of the mtr locus.; Remark: the N. crassa mtr gene product is covered by patent WO9521263-A1 (AC# AAR79909).; Title: strong similarity to neutral amino acid permease mtr - Neurospora crassa; plasma membrane; See PMID 2843424; See PMID 8001794; See PMID 1838345; uncharacterized protein 829461 4983902 An09g03660 Aspergillus niger uncharacterized protein XP_059606270.1 827664 R 5061 CDS An09g03680 84592018 join(830717..830842,830928..831029,831070..831410,831537..831726,831912..832058) I 1 NT_166525.1 hypothetical protein 832058 84592018 An09g03680 Aspergillus niger hypothetical protein XP_059606271.1 830717 D 5061 CDS An09g03690 84592019 complement(join(832743..832859,832934..833077,833267..833349,833438..833534,833816..833923)) I 1 NT_166525.1 hypothetical protein 833923 84592019 An09g03690 Aspergillus niger hypothetical protein XP_059606272.1 832743 R 5061 CDS An09g03700 4983905 complement(join(834463..835385,835561..835795,835849..836352)) I 1 NT_166525.1 Title: similarity to hypothetical protein C09F12.2 -Caenorhabditis elegans; uncharacterized protein 836352 4983905 An09g03700 Aspergillus niger uncharacterized protein XP_059606273.1 834463 R 5061 CDS An09g03710 4983906 complement(join(837773..838449,838495..838891)) I 1 NT_166525.1 Similarity: weak similarity to C2H2 zinc finger protein Zas1A S. pombe.; Title: weak similarity to hypothetical protein encoded by An14g01970 - Aspergillus niger; uncharacterized protein 838891 4983906 An09g03710 Aspergillus niger uncharacterized protein XP_001393687.3 837773 R 5061 CDS An09g03720 4983907 839403..840311 I 1 NT_166525.1 Title: similarity to actVA-ORF4-like protein A-ORFP from patent WO9911793-A1 - Homo sapiens; uncharacterized protein 840311 4983907 An09g03720 Aspergillus niger uncharacterized protein XP_001393688.1 839403 D 5061 CDS An09g03730 4983908 complement(join(840607..842618,842969..842975)) I 1 NT_166525.1 Induction: the E. coli aidB dehydrogenase is induced by alkylating agents.; Similarity: the E. coli aidB dehydrogenase belongs to the acyl-CoA dehydrogenase family.; Title: strong similarity to acyl CoA dehydrogenase aidB - Escherichia coli; See PMID 7713936; uncharacterized protein 842975 4983908 An09g03730 Aspergillus niger uncharacterized protein XP_001393689.3 840607 R 5061 CDS An09g03740 4983909 843537..844472 I 1 NT_166525.1 Similarity: weak similarities to phosphoesterases (EC 3. 1. -. -).; Title: strong similarity to hypothetical protein 239AB - Homo sapiens; uncharacterized protein 844472 4983909 An09g03740 Aspergillus niger uncharacterized protein XP_001393690.1 843537 D 5061 CDS An09g03750 4983910 complement(join(844913..845508,845568..845772,845825..845879,845936..846200,846261..846378,846432..846549,846600..846727,846785..846864,846920..847047,847103..847209,847263..847358,847407..847421,847469..847556,847606..847774,847825..847975)) I 1 NT_166525.1 Similarity: similarities correspond to multiple serine and threonine repeats.; Title: weak similarity to hypothetical fibroin 3 -Plectreurys tristis; uncharacterized protein 847975 4983910 An09g03750 Aspergillus niger uncharacterized protein XP_059606274.1 844913 R 5061 CDS An09g03760 10098221 complement(join(849956..851009,851061..851154,851209..851253,851304..851387,851438..851554,851614..852085)) I 1 NT_166525.1 Catalytic activity: Triacylglycerol + H2O = Diacylglycerol + a Carboxylate; Diacylglycerol + H2O = Monoacylglycerol + a Carboxylate.; Function: the lip I lipase of G. candidum hydrolyzes triacylglycerols into fatty acids and glycerol.; Remark: different G. candidum strains produce different isoforms of extracellular lipases I + II,diverging in substrate specifity.; Title: strong similarity to triacylglycerol lipase lipI - Geotrichum candidum; See PMID 2341377; See PMID 7578238; See PMID 8306978; See PMID 8370674; uncharacterized protein 852085 10098221 An09g03760 Aspergillus niger uncharacterized protein XP_003188795.2 849956 R 5061 CDS An09g03770 4983912 complement(853609..854379) I 1 NT_166525.1 hypothetical protein 854379 4983912 An09g03770 Aspergillus niger hypothetical protein XP_001393693.1 853609 R 5061 CDS An09g03780 4983913 join(856630..856953,857005..857449,857497..857585,857641..858033) I 1 NT_166525.1 Catalytic activity: hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1; hydrolyses peptide amides.; Gene-ID: pepD; Mapping: pepD from A. niger is mapped to chromosome I (LG I); see list from DSM, PUBMED 9309173.; Remark: engineered A. niger mutants which are unable to produce functional PEPD can be used for increased recombinant production of heterologous proteins.; Remark: mutant subtilisin-type serine protease derived from Aspergillus niger - used to transform hosts to confer reduced protease activity, for improved yields in protein expression.; Remark: the reduced identity is due to the use of low complexity filter in the calculation of BLAST similarities.; vacuole; subtilisin-like serine protease pepD-Aspergillus niger 858033 pepD 4983913 pepD Aspergillus niger subtilisin-like serine protease pepD-Aspergillus niger XP_001393694.1 856630 D 5061 CDS An09g03790 4983914 join(858660..858847,858940..858961,859009..859082,859133..859462,859517..860329,860544..860570,860618..860798) I 1 NT_166525.1 Remark: disruption of FLU1 in C. albicans had only a slight effect on fluconazole susceptibility but resulted in hypersusceptibility to mycophenolic acid.; Remark: expression of FLU1 in C. albicans YKKB-13 mutants, lacking the ABC transporter gene PDR5, mediated resistance to fluconazole and also to cycloheximide.; Similarity: belongs to the multidrug efflux transporter family.; Similarity: no similarity in N-terminus.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 8585712; See PMID 9124851; See PMID 11065353; uncharacterized protein 860798 4983914 An09g03790 Aspergillus niger uncharacterized protein XP_059606275.1 858660 D 5061 CDS An09g03800 4983915 complement(join(862045..862154,862233..862509,862576..863060,863371..863428)) I 1 NT_166525.1 Remark: other uses include peptide hydrolysis, waste treatment and cleavage of fusion proteins.; Remark: the B. subtilis hydrolase YQJL as well as other recombinant hydrolases from gram-positive bacteria are useful in cleaning (e. g. detergent) or textile treatment compositions, and in animal feeds.; Title: strong similarity to hydrolase protein YQJL from patent WO9927081-A2 - Bacillus subtilis; uncharacterized protein 863428 4983915 An09g03800 Aspergillus niger uncharacterized protein XP_059606276.1 862045 R 5061 CDS An09g03810 4983916 join(864645..864940,865024..866042,866078..866214) I 1 NT_166525.1 Remark: disruption of FLU1 in C. albicans had only a slight effect on fluconazole susceptibility but resulted in hypersusceptibility to mycophenolic acid.; Remark: expression of FLU1 in C. albicans YKKB-13 mutants, lacking the ABC transporter gene PDR5, mediated resistance to fluconazole and also to cycloheximide.; Similarity: belongs to the multidrug efflux transporter family.; Similarity: no similarity to N-terminus of C. albicans FLU1.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 8585712; See PMID 9124851; See PMID 11065353; uncharacterized protein 866214 4983916 An09g03810 Aspergillus niger uncharacterized protein XP_059606277.1 864645 D 5061 CDS An09g03820 4983917 complement(join(866322..867198,867250..867687,867717..868411)) I 1 NT_166525.1 Remark: mutational evidence suggests that the tamA gene has a positive role together with areA in regulating the expression of genes subject to nitrogen metabolite repression.; Remark: the A. nidulans tamA sequence shares significant homology with the UGA35/DAL81/DURL gene of S. cerevisiae.; Similarity: contains Zn-cluster domain generally involved in DNA-binding.; Title: strong similarity to nitrogen regulatory protein tamA - Aspergillus nidulans; See PMID 8655534; See PMID 10079333; See PMID 10471703; uncharacterized protein 868411 4983917 An09g03820 Aspergillus niger uncharacterized protein XP_059606278.1 866322 R 5061 CDS An09g03830 4983918 868689..870017 I 1 NT_166525.1 Catalytic activity: 2,2-dialkylglycine + pyruvate = dialkyl ketone + CO(2) + L-alanine.; Cofactor: pyridoxal phosphate.; Complex: homotetramer.; Remark: the dialkylglycine decarboxylase catalyzes both decarboxylation and amino transfer.; Similarity: belongs to the class-III of pyridoxal-phosphate-dependent aminotransferases.; Title: strong similarity to 2,2-dialkylglycine decarboxylase structural protein dgdA - Pseudomonas cepacia; cytoplasm; uncharacterized protein 870017 4983918 An09g03830 Aspergillus niger uncharacterized protein XP_001393699.1 868689 D 5061 CDS An09g03840 84592020 complement(join(870406..870858,870919..871240,871296..871439,871493..871560)) I 1 NT_166525.1 Title: strong similarity to hypothetical 65.9 kd protein SPAC31A2.12 - Schizosaccharomyces pombe; uncharacterized protein 871560 84592020 An09g03840 Aspergillus niger uncharacterized protein XP_059606279.1 870406 R 5061 CDS An09g03850 4983920 complement(872760..874799) I 1 NT_166525.1 Similarity: similarity corresponds only to a central region of ORF2706 from H. sapiens; Title: similarity to ORFX ORF2706 polypeptide from patent WO200058473-A2 - Homo sapiens; uncharacterized protein 874799 4983920 An09g03850 Aspergillus niger uncharacterized protein XP_001393701.1 872760 R 5061 CDS An09g03860 4983921 join(875973..876042,876105..876182,876253..876770) I 1 NT_166525.1 Title: similarity to calcium binding protein P22 -Gallus gallus; centrosome; See PMID 7769011; uncharacterized protein 876770 4983921 An09g03860 Aspergillus niger uncharacterized protein XP_001393702.1 875973 D 5061 CDS An09g03870 4983922 join(877279..877323,877394..879766) I 1 NT_166525.1 Catalytic activity: Citrate = cis-aconitate + H(2)O,also converts isocitrate into cis-aconitate.; Complex: monomer.; Function: required for growth on non-fermentable carbon sources and for biosynthesis of glutamate.; Localization: mitochondrial and extramitochondrial.; Pathway: tricarboxylic acid cycle.; Remark: Aconitase has an active (4Fe-4S) and an inactive (3Fe-4S) forms.; Remark: the active (4Fe-4S) cluster is part of the catalytic site that interconverts citrate, cis-aconitase and iso-citrate.; Similarity: belongs to the aconitase/IPM isomerase family.; Title: strong similarity to mitochondrial aconitase hydroxylase Aco1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 1972545; uncharacterized protein 879766 4983922 An09g03870 Aspergillus niger uncharacterized protein XP_001393703.1 877279 D 5061 CDS An09g03880 4983923 complement(join(880057..880191,880261..880614,880677..880886,880921..880958,881033..881911,881967..882094,882157..882305,882367..882573)) I 1 NT_166525.1 Similarity: similarities correspond to multiple threonine and proline residues.; Title: weak similarity to hypothetical polythreonine protein AAB61262.1 - Cryptosporidium parvum; uncharacterized protein 882573 4983923 An09g03880 Aspergillus niger uncharacterized protein XP_059606280.1 880057 R 5061 CDS An09g03890 4983924 complement(join(882946..883164,883219..883500,883550..883632,883684..883800,883847..883961,884012..884191)) I 1 NT_166525.1 Similarity: no similarity in N-terminus.; Title: strong similarity to hydroxic acid dehydrogenase-like protein from patent DE19912706-A1 -Staphylococcus aureus; uncharacterized protein 884191 4983924 An09g03890 Aspergillus niger uncharacterized protein XP_001393705.1 882946 R 5061 CDS An09g03900 4983925 join(884644..884709,884770..885921) I 1 NT_166525.1 Catalytic activity: L-iditol + NAD(+) = L-sorbose + NADH, also acts on D-glucitol (giving D-fructose) and other closely related sugar alcohols.; Cofactor: Zn2+.; Complex: homotetramer.; Function: also catalyzes the oxidation by NAD+ of sorbitol to fructose.; Similarity: belongs to the Zinc-containing alcohole-dehydrogenase-family.; Title: strong similarity to L-iditol-2 dehydrogenase SORD - Homo sapiens; uncharacterized protein 885921 4983925 An09g03900 Aspergillus niger uncharacterized protein XP_001393706.1 884644 D 5061 CDS An09g03910 84592021 complement(join(886659..886877,886967..887124,887417..887723)) I 1 NT_166525.1 Similarity: weak similarity to C-terminus of cotransporter protein SNST1 patent US5410031-A -Oryctolagus cuniculus.; hypothetical protein 887723 84592021 An09g03910 Aspergillus niger hypothetical protein XP_059606281.1 886659 R 5061 CDS An09g03920 4983927 complement(join(888043..888187,888246..888691,888746..889139,889198..889670)) I 1 NT_166525.1 Function: hydration and nonoxidative cleavage of feruloyl-SCoA to vanillin and acetyl-SCoA.; Title: strong similarity to p-hydroxycinnamoyl CoA hydratase/lyase vdh - Pseudomonas fluorescens; See PMID 9461612; See PMID 10543794; uncharacterized protein 889670 4983927 An09g03920 Aspergillus niger uncharacterized protein XP_001393708.1 888043 R 5061 CDS An09g03930 4983928 join(889991..890177,890232..890302,890372..890745,890775..891267) I 1 NT_166525.1 Function: the product of the pathogenicity gene Pth11p protein of M. grisea required for initiation of infection structure formation; Remark: the Pth11p protein of M. grisea can activate appressorium differentiation in response to inductive substrate cues.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529; uncharacterized protein 891267 4983928 An09g03930 Aspergillus niger uncharacterized protein XP_059606282.1 889991 D 5061 CDS An09g03940 4983929 join(892616..893793,893867..893894) I 1 NT_166525.1 Function: the homologous gene Ilv-2 of N. crassa encodes alpha-keto-beta-hydroxylacyl reductoisomerase,required for the synthesis of isoleucine and valine.; Title: strong similarity to ketol-acid reductoisomerase ilv-2 - Neurospora crassa; uncharacterized protein 893894 4983929 An09g03940 Aspergillus niger uncharacterized protein XP_001393710.1 892616 D 5061 CDS An09g03950 4983930 complement(join(894420..894782,894845..895169,895225..895722,895794..895909)) I 1 NT_166525.1 Catalytic activity: ATP + L-Tryptophan + tRNA(Trp) = AMP + Pyrophosphate + L-Tryptophanyl-tRNA(Trp).; Title: strong similarity to cytosolic tryptophan--tRNA ligase Wrs1 - Saccharomyces cerevisiae; cytoplasm; See PMID 9046085; uncharacterized protein 895909 4983930 An09g03950 Aspergillus niger uncharacterized protein XP_001393711.1 894420 R 5061 CDS An09g03960 4983931 join(896408..896744,896818..897614) I 1 NT_166525.1 Function: catalyzes L-serine to D-serine racemization.; Title: strong similarity to serine racemase - Mus musculus; uncharacterized protein 897614 4983931 An09g03960 Aspergillus niger uncharacterized protein XP_001393712.1 896408 D 5061 CDS An09g03970 4983932 complement(join(897938..897995,898034..898908,899095..899379)) I 1 NT_166525.1 Remark: M. musculus XRCC2 protein is a highly conserved novel member of the recA/RAD51 recombination repair gene family, involved in high fidelity repair processes in mammals.; Similarity: similarity is restricted to the central region of M. musculus XRCC2 protein.; Title: similarity to recA/RAD51 family protein XRCC2 - Mus musculus; See PMID 9512535; See PMID 9628903; uncharacterized protein 899379 4983932 An09g03970 Aspergillus niger uncharacterized protein XP_059606283.1 897938 R 5061 CDS An09g03980 4983933 complement(join(900044..900831,900893..901163)) I 1 NT_166525.1 Function: the prodos protein of D. melanogaster is a transcriptional coactivator that associates with a member of the general transcription factor TFIID.; Title: similarity to prodos protein prod -Drosophila melanogaster; See PMID 11134347; uncharacterized protein 901163 4983933 An09g03980 Aspergillus niger uncharacterized protein XP_001393714.1 900044 R 5061 CDS An09g03990 4983934 join(901640..901666,901767..901809,901960..901995,902093..902172) I 1 NT_166525.1 Catalytic activity: 4 ferrocytochrome c + O(2) = 4 ferricytochrome c + 2 H(2)O.; Function: the small integral protein COX9 plays a role in holoenzyme assembly or stability of cytochrome c oxidase (respirarory chain complex).; Localization: mitochondrial inner membrane.; Title: similarity to subunit VIIa of cytochrome c oxidase Cox9 - Saccharomyces cerevisiae; localisation:mitochondrion; uncharacterized protein 902172 4983934 An09g03990 Aspergillus niger uncharacterized protein XP_001393715.1 901640 D 5061 CDS An09g04000 4983935 complement(join(902812..902964,903077..903337)) I 1 NT_166525.1 Catalytic activity: hUbc12 of H sapiens catalyses ATP + ubiquitin + protein lysine <=> AMP + diphosphate + protein N-ubiquityllysine.; Function: ubiquitin-conjugating enzymes (UBC or E2 enzymes) catalyze the covalent attachment of ubiquitin to target proteins.; Similarity: additionally, the ORF shows similarity to human NCE-1 protein of patent WO9932624-A1.; Title: strong similarity to ubiquitin conjugating enzyme hUbc12 - Homo sapiens; uncharacterized protein 903337 4983935 An09g04000 Aspergillus niger uncharacterized protein XP_001393716.3 902812 R 5061 CDS An09g04010 4983936 complement(join(904461..904598,904667..905496,905564..906410,906462..906823,906888..907368,907452..907538)) I 1 NT_166525.1 Catalytic activity: UDP-N-acetyl-D-glucosamine + [1,4-(N-Acetyl-beta-D-glucosaminyl)]n = UDP + [1,4-(N-Acetyl-beta-D-glucosaminyl)]n+1.; Pathway: aminosugars metabolism.; Phenotype: disruption of chsC in A. fumigatus leads to no phenotype, however, disruption of of chsC together with chsG (another class III chitin synthase) leads to reduced colony radial growth rate and chitin synthase activity, the fungi conidiate poorly and produce highly branched hyphae.; Remark: chsC of A. fumigatus is a class III chitin synthase.; Title: strong similarity to chitin synthase C chsC -Aspergillus fumigatus; See PMID 8736545; See PMID 10731706; uncharacterized protein 907538 4983936 An09g04010 Aspergillus niger uncharacterized protein XP_001393717.1 904461 R 5061 CDS An09g04020 84592022 complement(join(910036..910245,910502..910525,910595..910741)) I 1 NT_166525.1 Remark: the ORF has an unusual exon/intron structure for A. niger.; hypothetical protein 910741 84592022 An09g04020 Aspergillus niger hypothetical protein XP_059606284.1 910036 R 5061 CDS An09g04030 4983938 912653..913555 I 1 NT_166525.1 Title: weak similarity to hypothetical protein encoded by An01g10470 - Aspergillus niger; uncharacterized protein 913555 4983938 An09g04030 Aspergillus niger uncharacterized protein XP_001393719.3 912653 D 5061 CDS An09g04040 84592023 complement(join(915220..915308,915345..915414,915492..915548,915602..915657,915730..915967,916058..916102,916180..916224,916328..916366)) I 1 NT_166525.1 hypothetical protein 916366 84592023 An09g04040 Aspergillus niger hypothetical protein XP_059606285.1 915220 R 5061 CDS An09g04050 4983940 join(916394..916430,916489..917753) I 1 NT_166525.1 Title: strong similarity to hypothetical OPY2 like protein CAD21287.1 - Neurospora crassa; uncharacterized protein 917753 4983940 An09g04050 Aspergillus niger uncharacterized protein XP_001393721.1 916394 D 5061 CDS An09g04060 4983941 complement(join(918211..919185,919246..919437,919491..920025,920155..920255)) I 1 NT_166525.1 Similarity: the predicted A. niger protein shows similarity to several hypothetical Zn(2)-Cys(6) zinc-finger proteins.; Title: strong similarity to hypothetical conserved protein 17E5.150 - Neurospora crassa; uncharacterized protein 920255 4983941 An09g04060 Aspergillus niger uncharacterized protein XP_001393722.3 918211 R 5061 CDS An09g04070 4983942 join(920696..920770,920856..920945,921000..921181,921235..921604,921653..921805) I 1 NT_166525.1 Catalytic activity: 2, 5-diketo-D-gluconate reductase of E. coli catalyses the reduction of 2,5-diketo-D-gluconate to 2-keto-L-gulonate.; Remark: 2,5-diketo-D-gluconate reductase of E. coli is active with NADPH as a preferred electron donor.; Similarity: the predicted A. niger protein shows strong similarity to 2,5-diketo-D-gluconate reductase (yqhE) from E. coli and many other oxidoreductases.; Title: strong similarity to 2,5-diketo-D-gluconate reductase yqhE - Escherichia coli; See PMID 10427017; uncharacterized protein 921805 4983942 An09g04070 Aspergillus niger uncharacterized protein XP_059606286.1 920696 D 5061 CDS An09g04080 4983943 join(922046..922068,922116..923004) I 1 NT_166525.1 Catalytic activity: gamma-glutamylcysteine synthetase of R. norvegicus catalyses the reaction ATP + L-glutamate + L-cysteine = ADP + orthophosphate + gamma-L-glutamyl-L-cysteine.; Complex: functional gamma-glutamylcysteine synthetase of R. norvegicus consists of one light subunit and one heavy subunit.; Pathway: gamma-glutamylcysteine synthetase catalyses the first step of glutathione (GSH) synthesis. the enzyme is also involved in glutamate metabolism.; Remark: gamma-glutamylcysteine synthetase can use L-aminohexanoate in place of glutamate.; Similarity: the predicted A. niger protein shows strong similarity to gamma-glutamylcysteine synthetase light chain from R. norvegicus and from other species.; Title: strong similarity to gamma-glutamylcysteine synthase light chain - Rattus norvegicus; See PMID 8104188; uncharacterized protein 923004 4983943 An09g04080 Aspergillus niger uncharacterized protein XP_001393724.1 922046 D 5061 CDS An09g04090 4983944 complement(join(923202..923623,923789..924110)) I 1 NT_166525.1 Similarity: best blastp matches in the patent database are protein kinases.; Title: strong similarity to hypothetical protein mNori-2 - Mus musculus; uncharacterized protein 924110 4983944 An09g04090 Aspergillus niger uncharacterized protein XP_059606287.1 923202 R 5061 CDS An09g04100 4983945 complement(join(924541..928798,928888..928982)) I 1 NT_166525.1 Catalytic activity: n nucleoside triphosphate = n pyrophosphate + RNA(n).; Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.; Remark: RPO31 of S. cerevisiae is also known as RPC1, RPC160 and YOR116C.; Title: strong similarity to 160 kD subunit of DNA-directed RNA polymerase III Rpo31 - Saccharomyces cerevisiae; nucleus; See PMID 3021184; See PMID 3896517; uncharacterized protein 928982 4983945 An09g04100 Aspergillus niger uncharacterized protein XP_001393726.1 924541 R 5061 CDS An09g04110 4983946 complement(join(929442..930705,930764..931500)) I 1 NT_166525.1 Remark: LepA of E. coli is a membrane-bound GTP-binding protein.; Remark: the sequence of yeast Guf1p is almost identical with the sequence given in patent # US5674996-A (yeast checkpoint control protein MEC3, acc. # AAW26665) . the sequence in this patent is different from the sequence of public S. cerevisiae MEC3.; Remark: yeast GUF1 (GTPase of Unknown Function) is located in a region of chromosome IV adjacent to the checkpoint gene MEC3.; Similarity: the predicted A. niger protein shows strong similarity to lepA from E. coli, which belongs to the family of elongation factor-type GTP-binding proteins. these proteins are highly conserved in procaryotes and eucaryotes.; Title: strong similarity to GTP-binding protein lepA - Escherichia coli; See PMID 2999765; uncharacterized protein 931500 4983946 An09g04110 Aspergillus niger uncharacterized protein XP_001393727.1 929442 R 5061 CDS An09g04120 4983947 join(931766..931814,931864..931889,931943..931968,932020..932058,932111..932139,932190..932343,932515..932806) I 1 NT_166525.1 Function: feedback control that prevents cells with incompletely assembled spindles from leaving mitosis; Title: strong similarity to spindle checkpoint protein Mad2 - Saccharomyces cerevisiae; See PMID 1651172; uncharacterized protein 932806 4983947 An09g04120 Aspergillus niger uncharacterized protein XP_059606288.1 931766 D 5061 CDS An09g04130 4983948 complement(join(932972..933496,933600..933651,933806..933913,934007..934101)) I 1 NT_166525.1 Title: strong similarity to hypothetical protein 12F11.190 - Neurospora crassa; uncharacterized protein 934101 4983948 An09g04130 Aspergillus niger uncharacterized protein XP_001393729.1 932972 R 5061 CDS An09g04140 84592024 complement(join(934806..934898,934951..935541,935592..935833,935894..936285,936340..936866)) I 1 NT_166525.1 Title: similarity to hypothetical protein encoded by gene 51 - Murid herpesvirus 4; uncharacterized protein 936866 84592024 An09g04140 Aspergillus niger uncharacterized protein XP_059606289.1 934806 R 5061 CDS An09g04150 4983950 complement(join(937023..937969,938020..938195,938256..938395,938481..939107)) I 1 NT_166525.1 Title: strong similarity to hypothetical transcriptional activator ptaA - Aspergillus nidulans; See PMID 11309119; uncharacterized protein 939107 4983950 An09g04150 Aspergillus niger uncharacterized protein XP_059606290.1 937023 R 5061 CDS An09g04160 84592025 939680..940042 I 1 NT_166525.1 hypothetical protein 940042 84592025 An09g04160 Aspergillus niger hypothetical protein XP_059606291.1 939680 D 5061 CDS An09g04170 4983952 join(940815..940854,940918..941134,941206..941588,941643..943120) I 1 NT_166525.1 Complex: SLY1 of S. cerevisiae binds to Sed5.; Function: SLY1 of S. cerevisiae is essential and has a role in vesicular trafficking from the endoplasmic reticulum to the Golgi apparatus.; Remark: SLY1 of S. cerevisiae is also known as YDR189W.; Similarity: belongs to the STXBP/UNC-18/SEC1 family.; Title: strong similarity to protein Sly1 -Saccharomyces cerevisiae; See PMID 9271199; See PMID 11481671; See PMID 1990290; uncharacterized protein 943120 4983952 An09g04170 Aspergillus niger uncharacterized protein XP_001393733.1 940815 D 5061 CDS An09g04180 4983953 complement(join(943545..943939,944000..944741)) I 1 NT_166525.1 Function: STE2 of S. cerevisiae has a role in transmitting mating pheromone to the G protein thereby activating it, which leads to growth arrest in G1 and the subsequent induction of mating genes.; Localization: STE2 of S. cerevisiae is an integral membrane protein.; Phenotype: a N388S mutation in STE2 of S. cerevisiae leads to a reduction in growth arrest after phermone treatment and impaired mating competence.; Remark: STE2 of S. cerevisiae is also known as YFL026W.; Similarity: belongs to family 4 of G-protein coupled receptors; Title: similarity to pheromone alpha-factor receptor Ste2 - Saccharomyces cerevisiae; See PMID 2839507; See PMID 3001640; See PMID 1128714; uncharacterized protein 944741 4983953 An09g04180 Aspergillus niger uncharacterized protein XP_001393734.1 943545 R 5061 CDS An09g04190 4983954 join(945987..946250,946303..946411,946476..946714,946770..948119) I 1 NT_166525.1 Title: weak similarity to tumor susceptibility protein tsg101 - Mus musculus; uncharacterized protein 948119 4983954 An09g04190 Aspergillus niger uncharacterized protein XP_001393735.3 945987 D 5061 CDS An09g04200 4983955 complement(join(948404..948409,948594..948900,948959..949080)) I 1 NT_166525.1 hypothetical protein 949080 4983955 An09g04200 Aspergillus niger hypothetical protein XP_001393736.3 948404 R 5061 CDS An09g04210 4983956 join(950269..950442,950511..951135,951243..951346) I 1 NT_166525.1 Title: weak similarity to hypothetical protein encoded by An15g01210 - Aspergillus niger; uncharacterized protein 951346 4983956 An09g04210 Aspergillus niger uncharacterized protein XP_001393737.3 950269 D 5061 CDS An09g04230 4983958 join(952105..952319,952449..952783,952845..953149,953205..953388,953430..953623) I 1 NT_166525.1 Remark: the encoded protein shows similarities to protein kinases from other organisms.; Title: similarity to protein kinase STY - Mus musculus; See PMID 7665564; See PMID 8617202; See PMID 1825055; See PMID 1986248; uncharacterized protein 953623 4983958 An09g04230 Aspergillus niger uncharacterized protein XP_059606292.1 952105 D 5061 CDS An09g04240 4983959 complement(join(953924..954325,954423..954563)) I 1 NT_166525.1 Title: similarity to hypothetical protein CAD37005.1 - Neurospora crassa; uncharacterized protein 954563 4983959 An09g04240 Aspergillus niger uncharacterized protein XP_059606293.1 953924 R 5061 CDS An09g04250 4983960 complement(join(955058..956233,956285..956575)) I 1 NT_166525.1 Catalytic activity: murine indoleamine 2,3-dioxygenase catalyses the reaction L-tryptophan + O2 = N-formylkynurenine.; Cofactor: murine indoleamine 2,3-dioxygenase requires heme as a cofactor.; Pathway: murine indoleamine 2,3-dioxygenase is involved in tryptophan catabolism.; Remark: indoleamine 2,3-dioxygenase acts on many substituted and unsubstituted indoleamines, including melatonin.; Similarity: the predicted A. niger protein shows strong similarity to murine indoleamine 2,3-dioxygenase,orthologues in other vertebrate species, the hypothetical yeast protein YJR078w and heme binding invertebrate myoglobins.; Title: strong similarity to indoleamine 2,3-dioxygenase IDO - Mus musculus; uncharacterized protein 956575 4983960 An09g04250 Aspergillus niger uncharacterized protein XP_001393740.1 955058 R 5061 CDS An09g04260 84592026 complement(join(956718..956933,956995..957301,957349..957419)) I 1 NT_166525.1 hypothetical protein 957419 84592026 An09g04260 Aspergillus niger hypothetical protein XP_059606294.1 956718 R 5061 CDS An09g04270 84592027 join(957559..957683,957773..957878,958021..958081,958165..958214) I 1 NT_166525.1 hypothetical protein 958214 84592027 An09g04270 Aspergillus niger hypothetical protein XP_059606295.1 957559 D 5061 CDS An09g04280 4983963 complement(join(958608..959030,959265..960389)) I 1 NT_166525.1 Function: involved in tRNA-processing; Similarity: belongs to class-V of pyridoxal-phosphate-dependent aminotransferases; Similarity: strong, to nifs from nitrogen fixing bacteria; Title: strong similarity to tRNA splicing protein SPL1 - Candida maltosa; See PMID 8444805; See PMID 9544248; uncharacterized protein 960389 4983963 An09g04280 Aspergillus niger uncharacterized protein XP_001393743.1 958608 R 5061 CDS An09g04290 84592028 complement(join(960707..960992,961045..961157,961252..961287,961454..961504)) I 1 NT_166525.1 hypothetical protein 961504 84592028 An09g04290 Aspergillus niger hypothetical protein XP_059606296.1 960707 R 5061 CDS An09g04300 4983965 join(961792..961975,962038..963131) I 1 NT_166525.1 Function: RVS167 from S. cerevisiae is involved in cortical actin cytoskeleton organization.; Similarity: the predicted A. niger protein shows strong similarity to RVS167 from S. cerevisiae, which is a homologue of higher eukaryotes' amphiphysins. the yeast RVS167 gene product displays significant homology with the yeast Rvs161 protein and contains a SH3 domain at the C-terminal end.; Title: strong similarity to protein involved in actin distribution and bipolar budding Rsv167 -Saccharomyces cerevisiae; cytoskeleton; See PMID 8336735; See PMID 10393809; See PMID 10992286; uncharacterized protein 963131 4983965 An09g04300 Aspergillus niger uncharacterized protein XP_059606297.1 961792 D 5061 CDS An09g04310 84592029 complement(join(964261..964288,964342..964783,964878..965193)) I 1 NT_166525.1 hypothetical protein 965193 84592029 An09g04310 Aspergillus niger hypothetical protein XP_059606298.1 964261 R 5061 CDS An09g04330 84592030 join(965436..965915,966018..966339,966716..966759,966962..967066,967138..967455) I 1 NT_166525.1 Title: weak similarity to pro-phenol oxidase subunit 1 proPO-p1 - Anopheles gambiae; uncharacterized protein 967455 84592030 An09g04330 Aspergillus niger uncharacterized protein XP_059606299.1 965436 D 5061 CDS An09g04335 4983968 join(969014..969364,969432..969482) I 1 NT_166525.1 Remark: the ORF is truncated due to a transposon insertion.; hypothetical protein [truncated ORF] 969482 4983968 An09g04335 Aspergillus niger hypothetical protein [truncated ORF] XP_001393748.1 969014 D 5061 CDS An09g04350 84592031 complement(969656..970864) I 1 NT_166525.1 Remark: the ORF encoded protein probably does not belong to the genome of A. niger, it is identical with the transposase of insertion sequence IS10 from Escherichia coli. This sequence could be inserted during subcloning or sequencing of the A. niger DNA.; Title: strong similarity to transposase of insertion sequence IS10 - Escherichia coli [putative cloning actefact]; See PMID 8132525; uncharacterized protein 970864 84592031 An09g04350 Aspergillus niger uncharacterized protein XP_059606300.1 969656 R 5061 CDS An09g04360 4983970 join(971922..972272,972340..972390) I 1 NT_166525.1 Title: weak similarity to hypothetical protein SPy1903 - Streptococcus pyogenes; uncharacterized protein 972390 4983970 An09g04360 Aspergillus niger uncharacterized protein XP_001393750.1 971922 D 5061 CDS An09g04370 4983971 complement(972544..973446) I 1 NT_166525.1 Similarity: the N-terminal third of the predicted protein has no similarity to Rv0276 of M. tuberculosis.; Title: similarity to hypothetical protein Rv0276 -Mycobacterium tuberculosis; uncharacterized protein 973446 4983971 An09g04370 Aspergillus niger uncharacterized protein XP_001393751.1 972544 R 5061 CDS An09g04380 4983972 join(974218..974453,974518..974939,975002..975126,975179..975712) I 1 NT_166525.1 Title: weak similarity to hypothetical protein yqjA - Bacillus subtilis; uncharacterized protein 975712 4983972 An09g04380 Aspergillus niger uncharacterized protein XP_001393752.1 974218 D 5061 CDS An09g04390 4983973 join(976108..976591,976679..977039,977123..977585) I 1 NT_166525.1 Catalytic activity: salicylate + NADH + H(+) + O2 = catechol + NAD(+) + H2O + CO2.; Cofactor: salicylate hydroxylase of P. putida is a flavoprotein (FAD).; Function: salicylate hydroxylase of P. putida catalyzes the decarboxylative hydroxylation of salicylate.; Induction: salicylate hydroxylase of P. putida isinduced by salicylate.; Pathway: salicylate hydroxylase of P. putida is involved in the lower napthalene catabolic pathway which involves conversion of salicylate to lower amphibolic intermediates.; Title: strong similarity to salicylate hydroxylase sal - Pseudomonas putida; See PMID 7629025; See PMID 8695632; uncharacterized protein 977585 4983973 An09g04390 Aspergillus niger uncharacterized protein XP_059601391.1 976108 D 5061 CDS An09g04410 84592032 complement(join(978768..978977,979087..979207,980020..980145,980241..980273,980357..980517,980594..980676,980752..980837,980941..981144,981244..981387,981485..981540)) I 1 NT_166525.1 Similarity: the N-terminal part of the predicted protein shows weak similarity to Neutrophil chemotactic factor 2-beta preform, patent JP08020600-A, of R. norvegicus, but the proteins have very different length.; hypothetical protein 981540 84592032 An09g04410 Aspergillus niger hypothetical protein XP_059601392.1 978768 R 5061 CDS An09g04420 84592033 join(981709..981711,981890..981943,982133..982207) I 1 NT_166525.1 Title: questionable ORF; uncharacterized protein 982207 84592033 An09g04420 Aspergillus niger uncharacterized protein XP_059601393.1 981709 D 5061 CDS An09g04430 84592034 join(983334..983534,983734..983782,983831..984208,984366..984529,984803..984928) I 1 NT_166525.1 hypothetical protein 984928 84592034 An09g04430 Aspergillus niger hypothetical protein XP_059601394.1 983334 D 5061 CDS An09g04440 4983978 complement(join(985894..987723,987775..987939)) I 1 NT_166525.1 Title: strong similarity to hypothetical protein CAD70771.1 - Neurospora crassa; uncharacterized protein 987939 4983978 An09g04440 Aspergillus niger uncharacterized protein XP_001393757.1 985894 R 5061 CDS An09g04450 84592035 complement(join(988687..988790,988837..988983,989221..989397,989490..989566,989634..989734,989822..989927,990029..990183)) I 1 NT_166525.1 Similarity: several BLASTP matches are due to the C-terminal low complexity region, especially to the poly-glycine stretch, and cannot be considered significant.; hypothetical protein 990183 84592035 An09g04450 Aspergillus niger hypothetical protein XP_059601395.1 988687 R 5061 CDS An09g04460 84592036 join(991112..991366,991511..991667,991712..991797) I 1 NT_166525.1 hypothetical protein 991797 84592036 An09g04460 Aspergillus niger hypothetical protein XP_059601396.1 991112 D 5061 CDS An09g04470 4983981 join(992432..992523,992584..992786,992842..993252,993300..993375,993424..993741,993801..994017) I 1 NT_166525.1 Title: strong similarity to hypothetical protein YOR197w - Saccharomyces cerevisiae; uncharacterized protein 994017 4983981 An09g04470 Aspergillus niger uncharacterized protein XP_001393760.3 992432 D 5061 CDS An09g04480 84592037 complement(join(994304..994365,994407..994428,994512..994599,994631..994785,994868..994904,995128..995155,995257..995266)) I 1 NT_166525.1 Title: questionable ORF; uncharacterized protein 995266 84592037 An09g04480 Aspergillus niger uncharacterized protein XP_059601397.1 994304 R 5061 CDS An09g04490 84592038 join(997018..997048,997156..997221,997458..997615,997669..997782) I 1 NT_166525.1 Title: questionable ORF; uncharacterized protein 997782 84592038 An09g04490 Aspergillus niger uncharacterized protein XP_059601398.1 997018 D 5061 CDS An09g04500 84592039 complement(join(998318..998466,998492..998567)) I 1 NT_166525.1 hypothetical protein 998567 84592039 An09g04500 Aspergillus niger hypothetical protein XP_059601399.1 998318 R 5061 CDS An09g04510 4983985 complement(join(1000521..1000769,1000892..1000954,1001009..1001042,1001287..1001315,1001431..1001471,1001560..1001619,1001733..1001842,1002297..1002448,1002684..1002798,1003025..1003167,1003208..1003582)) I 1 NT_166525.1 Similarity: a poly-alanine stretch in the N-terminal part of the predicted ORF produces some additional non-significant BLASTP matches.; Similarity: the weak similarity to GP protein of the Marburg virus involves only the N-terminal fifth of the predicted protein.; Title: weak similarity to protein GP - Marburg virus; See PMID 8495737; uncharacterized protein 1003582 4983985 An09g04510 Aspergillus niger uncharacterized protein XP_001393764.3 1000521 R 5061 CDS An09g04520 4983986 join(1004645..1004794,1004855..1005415,1005469..1005534) I 1 NT_166525.1 Title: strong similarity to hypothetical membrane protein YLR285w - Saccharomyces cerevisiae; uncharacterized protein 1005534 4983986 An09g04520 Aspergillus niger uncharacterized protein XP_001393765.1 1004645 D 5061 CDS An09g04530 4983987 join(1005858..1005863,1005912..1006256,1006419..1006571,1006662..1007219) I 1 NT_166525.1 Function: KTI12 of S. cerevisiae is involved in resistance to K. lactis killer toxin, that causes cells to arrest in G1 phase.; Title: strong similarity to protein Kti12 -Saccharomyces cerevisiae; See PMID 8065362; See PMID 11296232; uncharacterized protein 1007219 4983987 An09g04530 Aspergillus niger uncharacterized protein XP_059601400.1 1005858 D 5061 CDS An09g04540 4983988 complement(join(1008567..1009200,1009253..>1009479)) I 1 NT_166525.1 Remark: N-terminally truncated ORF due to contig border.; Similarity: the similarities are mainly based on the zinc finger motifs.; Title: strong similarity to hypothetical protein EAA63983.1 - Aspergillus nidulans [truncated ORF]; uncharacterized protein 1009479 4983988 An09g04540 Aspergillus niger uncharacterized protein XP_001393767.3 1008567 R 5061 CDS An09g04550 84592040 complement(<1009610..1010230) I 1 NT_166525.1 Remark: C-terminally truncated ORF due to contig border.; Title: weak similarity to protein phosphatase type 1 Gac1 - Saccharomyces cerevisiae [truncated ORF]; See PMID 1310938; See PMID 1651919; uncharacterized protein 1010230 84592040 An09g04550 Aspergillus niger uncharacterized protein XP_059601401.1 1009610 R 5061 CDS An09g04560 84592041 join(1011718..1011979,1012070..1012152,1012292..1012645) I 1 NT_166525.1 hypothetical protein 1012645 84592041 An09g04560 Aspergillus niger hypothetical protein XP_059601402.1 1011718 D 5061 CDS An09g04570 84592042 join(1014143..1014364,1014410..1015879) I 1 NT_166525.1 Similarity: very weak, local similarity to E. coli TraD, a cell-envelope protein with unknown function.; hypothetical protein 1015879 84592042 An09g04570 Aspergillus niger hypothetical protein XP_059601403.1 1014143 D 5061 CDS An09g04580 4983992 join(1016246..1017232,1017404..1017409) I 1 NT_166525.1 Catalytic activity: palmitoyl-protein thioesterase of R. norvegicus catalyzes the reaction: palmitoyl-protein + H2O = palmitate + protein.; Catalytic activity: palmitoyl-protein thioesterase of R. norvegicus is specific for long-chain thioesters of fatty acids; hydrolyses fatty acids from S-acylated cysteine residues in proteins, palmitoyl cysteine and palmitoyl-CoA.; Phenotype: a protein showing very strong similarity to palmitoyl-protein thioesterase of R. norvegicus was isolated in humans as the gene mutated in infantile neuronal ceroid lipofuscinosis, a severe neurodegenerative disorder, characterized by the accumulation of proteolipid storage material in brain and other tissues, suggesting that the disease is a consequence of abnormal catabolism of acylated proteins.; Title: strong similarity to palmitoyl-protein thioesterase - Rattus norvegicus; See PMID 7901201; See PMID 7916016; See PMID 8786130; uncharacterized protein 1017409 4983992 An09g04580 Aspergillus niger uncharacterized protein XP_001393771.3 1016246 D 5061 CDS An09g04590 4983993 complement(join(1018031..1021241,1021311..1021525)) I 1 NT_166525.1 Similarity: the predicted ORF, in the same region,shows similarity to another protein patented under patentnumber EP0999284.; Similarity: the similarity to CaMR212 of C. albicans is limited to the C-terminal half of the predicted ORF.; Title: similarity to CaMR212 from patent WO200015838-A2 - Candida albicans; uncharacterized protein 1021525 4983993 An09g04590 Aspergillus niger uncharacterized protein XP_059601404.1 1018031 R 5061 CDS An09g04600 4983994 complement(1022880..1023335) I 1 NT_166525.1 Function: the human pancreatic cancer antigens have cytostatic, neuroprotective, nootropic, immunomodulatory,relaxant, contraceptive, gynaecological, cardiant and antiinflammatory activities, and can be used in gene therapy.; Title: similarity to pancreatic cancer antigen protein sequence SEQ ID NO:464 from patent WO200055320-A1 -Homo sapiens; uncharacterized protein 1023335 4983994 An09g04600 Aspergillus niger uncharacterized protein XP_001393773.1 1022880 R 5061 CDS An09g04610 84592043 join(1024429..1024618,1024726..1025405) I 1 NT_166525.1 hypothetical protein 1025405 84592043 An09g04610 Aspergillus niger hypothetical protein XP_059601405.1 1024429 D 5061 CDS An09g04620 4983996 join(1027831..1027884,1027951..1028389,1028451..1029250) I 1 NT_166525.1 Title: strong similarity to hypothetical protein YDR348c - Saccharomyces cerevisiae; uncharacterized protein 1029250 4983996 An09g04620 Aspergillus niger uncharacterized protein XP_001393775.1 1027831 D 5061 CDS An09g04630 84592044 join(1030023..1030026,1030284..1030327,1030549..1030653) I 1 NT_166525.1 Title: questionable ORF; uncharacterized protein 1030653 84592044 An09g04630 Aspergillus niger uncharacterized protein XP_059601406.1 1030023 D 5061 CDS An09g04640 4983998 complement(join(1031013..1031115,1031182..1031351,1031420..1033722,1033775..1033890,1033988..1033992)) I 1 NT_166525.1 Complex: nimQ/MCM2 is part of the DNA replication licensing complex, that binds chromatin in G1-phase and leaves chromatin when cells enter and progress through S-phase.; Function: the binding to the chromatin of the licensing factor or factors causes the chromatin to become competent for DNA replication, but once initiation of DNA replication has occurred, the licensing factor would be destroyed, thereby preventing re-replication of the DNA.; Localization: in S. cerevisiae most of MCM2 is distributed throughout the cell cycle to both cytoplasm and nucleoplasm at relatively constant levels.; Similarity: nimQ of A. nidulans is the functional homologue of MCM2 of S. cerevisiae.; Title: strong similarity to hypothetical DNA replication licensing factor nimQ - Aspergillus nidulans; See PMID 8882583; See PMID 9407133; See PMID 7701565; See PMID 8542275; See PMID 8720069; uncharacterized protein 1033992 4983998 An09g04640 Aspergillus niger uncharacterized protein XP_001393777.1 1031013 R 5061 CDS An09g04650 4983999 join(1034551..1034653,1034761..1034878,1034961..1035015,1035084..1035549,1035994..1036545,1036683..1036774) I 1 NT_166525.1 Title: similarity to hypothetical protein mlo2p -Schizosaccharomyces pombe; uncharacterized protein 1036774 4983999 An09g04650 Aspergillus niger uncharacterized protein XP_059601407.1 1034551 D 5061 CDS An09g04660 4984000 complement(join(1037031..1038102,1038156..1038315,1038573..1038627)) I 1 NT_166525.1 Function: UME5/SRB10 and UME3/SRB11 form a kinase-cyclin pair in the RNA polymerase II holoenzyme, and are essential for a normal transcriptional response to galactose induction in vivo, and are involved in CTD (carboxy-terminal domain) phosphorylation and this modification has a role in the response to transcriptional regulators in vivo.; Remark: SSN3, SRB10 and YPL042C are alternative names for UME5.; Remark: the ORF encoded protein also shows similarity to other cyclin dependend kinases.; Similarity: UME5 belongs to the ser/thr family of protein kinases. cdc2/cdkx subfamily.; Title: strong similarity to meiotic mRNA stability protein kinase Ume5 - Saccharomyces cerevisiae; deleted EC_number 2.7.1.37; See PMID 7877695; See PMID 8164691; uncharacterized protein 1038627 4984000 An09g04660 Aspergillus niger uncharacterized protein XP_059601408.1 1037031 R 5061 CDS An09g04670 84592045 complement(join(1039124..1039237,1039350..1039461,1039633..1039832)) I 1 NT_166525.1 hypothetical protein 1039832 84592045 An09g04670 Aspergillus niger hypothetical protein XP_059601409.1 1039124 R 5061 CDS An09g04680 4984002 join(1039899..1039997,1040064..1041437) I 1 NT_166525.1 Function: rat GLUT2 is sufficient to rescue E. coli mutant defective in glucose uptake.; Localization: immunofluorescence analysis showed that rat GLUT2 is present in the plasma membrane of the insulin-producing beta cells.; Title: similarity to hepatic glucose transport protein GLUT2 - Rattus norvegicus; plasma membrane; See PMID 3048704; uncharacterized protein 1041437 4984002 An09g04680 Aspergillus niger uncharacterized protein XP_001393781.1 1039899 D 5061 CDS An09g04690 4984003 complement(1042052..1043302) I 1 NT_166525.1 Title: strong similarity to hypothetical protein EAA74627.1 - Gibberella zeae; uncharacterized protein 1043302 4984003 An09g04690 Aspergillus niger uncharacterized protein XP_059601410.1 1042052 R 5061 CDS An09g04700 84592046 complement(join(1043375..1043572,1043645..1043697,1043783..1043924,1044010..1044268,1044379..1044461,1044770..1044950,1045113..1045409,1045505..1045540,1045624..1045681,1045773..1045887,1046048..1046135,1046259..1046374)) I 1 NT_166525.1 Title: weak similarity to hypothetical protein KLF12 - Homo sapiens; uncharacterized protein 1046374 84592046 An09g04700 Aspergillus niger uncharacterized protein XP_059601411.1 1043375 R 5061 CDS An09g04710 4984005 join(1046497..1046640,1046738..1046782,1046858..1047073,1047129..1047549,1047601..1048587,1048705..1049088,1049149..1049900,1049964..1050125) I 1 NT_166525.1 Catalytic activity: Phosphatidyl-L-serine = Phosphatidylethanolamine + CO2.; Remark: The yeast S. cerevisiae expresses two phosphatidylserine decarboxylase (PSD) activities which are responsible for conversion of phosphatidylserine to phosphatidylethanolamine, and either enzyme alone is sufficient for normal cellular growth.; Remark: YGR170w is the systematic name for PSD2 of S. cerevisiae.; Title: strong similarity to phosphatidylserine decarboxylase 2 Psd2 - Saccharomyces cerevisiae; See PMID 10793889; See PMID 7890740; uncharacterized protein 1050125 4984005 An09g04710 Aspergillus niger uncharacterized protein XP_059601412.1 1046497 D 5061 CDS An09g04720 84592047 join(1050400..1050480,1050557..1051018) I 1 NT_166525.1 hypothetical protein 1051018 84592047 An09g04720 Aspergillus niger hypothetical protein XP_059601413.1 1050400 D 5061 CDS An09g04730 4984007 join(1051158..1051365,1051473..1052135,1052168..1052332,1052380..1052548,1052591..1053179) I 1 NT_166525.1 Title: similarity to hypothetical protein 12F11.250 - Neurospora crassa; uncharacterized protein 1053179 4984007 An09g04730 Aspergillus niger uncharacterized protein XP_059601414.1 1051158 D 5061 CDS An09g04740 84592048 complement(join(1053488..1053555,1053862..1053934,1053979..1054154,1054306..1054357)) I 1 NT_166525.1 hypothetical protein 1054357 84592048 An09g04740 Aspergillus niger hypothetical protein XP_059601415.1 1053488 R 5061 CDS An09g04750 84592049 join(1055827..1055876,1055970..1056021,1056269..1056402,1056459..1056534,1056612..1056769,1056953..1057012,1057190..1057376) I 1 NT_166525.1 hypothetical protein 1057376 84592049 An09g04750 Aspergillus niger hypothetical protein XP_059601416.1 1055827 D 5061 CDS An09g04760 84592050 complement(join(1057397..1057552,1057634..1057726,1058084..1058185,1058275..1058364)) I 1 NT_166525.1 hypothetical protein 1058364 84592050 An09g04760 Aspergillus niger hypothetical protein XP_059601417.1 1057397 R 5061 CDS An09g04770 84592051 complement(join(1058470..1058594,1058751..1058918,1059106..1059249,1059410..1059464,1059637..1059824,1060011..1060176,1060274..1060375)) I 1 NT_166525.1 hypothetical protein 1060375 84592051 An09g04770 Aspergillus niger hypothetical protein XP_059601418.1 1058470 R 5061 CDS An09g04780 4984012 1060736..1063345 I 1 NT_166525.1 Title: similarity to hypothetical integral membrane protein - Schizosaccharomyces pombe; uncharacterized protein 1063345 4984012 An09g04780 Aspergillus niger uncharacterized protein XP_059601419.1 1060736 D 5061 CDS An09g04790 4984013 complement(1064857..1066587) I 1 NT_166525.1 Remark: blastp with the predicted A. niger protein only retrieves putative random hits to proline and glutamine rich proteins.; Title: weak similarity to enabled ena - Drosophila melanogaster; uncharacterized protein 1066587 4984013 An09g04790 Aspergillus niger uncharacterized protein XP_001393792.1 1064857 R 5061 CDS An09g04800 84592052 join(1067023..1067037,1067155..1067242,1067514..1067660,1068177..1068292) I 1 NT_166525.1 hypothetical protein 1068292 84592052 An09g04800 Aspergillus niger hypothetical protein XP_059601420.1 1067023 D 5061 CDS An09g04810 4984015 complement(join(1069322..1069518,1069575..1069673,1069724..1069824,1069874..1070072,1070129..1070216,1070271..1070817,1070881..1071155,1071216..1071287)) I 1 NT_166525.1 Function: K. lactis HGT1 is a high affinity glucose transporter.; Remark: expression of HGT1 from K. lactis is constitutive (in contrast to RAG1, the major gene for low-affinity glucose uptake in K. lactis) and is controlled by several genes also known to affect expression of RAG1.; Similarity: K. lactis HGT1 belongs to the sugar transporter family.; Title: strong similarity to high affinity glucose transporter HGT1 - Kluyveromyces lactis; plasma membrane; See PMID 8830679; uncharacterized protein 1071287 4984015 An09g04810 Aspergillus niger uncharacterized protein XP_001393794.1 1069322 R 5061 CDS An09g04820 4984016 join(1072756..1073056,1073122..1073277,1073352..1073674,1073749..1073818,1073893..1073990,1074060..1074225,1074331..1074359) I 1 NT_166525.1 Title: strong similarity to hypothetical protein CAD27299.1 - Aspergillus fumigatus; uncharacterized protein 1074359 4984016 An09g04820 Aspergillus niger uncharacterized protein XP_001393795.3 1072756 D 5061 CDS An09g04830 4984017 join(1076026..1076203,1076254..1076273,1076330..1076366,1076417..1076484,1076538..1077440) I 1 NT_166525.1 Function: the M. grisea PTH11 gene product is presumably involved in host surface recognition and can activate appressorium differentiation in response to inductive surface cues.; Similarity: similarity is between the N-terminal regions of the predicted A. niger protein and pth11 of M. grisea, which is 200 aa longer.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529; uncharacterized protein 1077440 4984017 An09g04830 Aspergillus niger uncharacterized protein XP_059601421.1 1076026 D 5061 CDS An09g04840 4984018 join(1077875..1077956,1078122..1078443,1078492..1079204,1079274..1080229) I 1 NT_166525.1 Function: S. cerevisiae TOK1 mediates outwardly-rectifying potassium currents activated by depolarization.; Regulation: Activation of S. cerevisiae Tok1 channels under steady-state conditions is dependent upon ATP in the cytoplasmic solution.; Remark: alternative names for S. cerevisiae TOK1 are YPK1, YORK and DUK1.; Title: strong similarity to outwardly-rectifying potassium channel Tok1 - Saccharomyces cerevisiae; plasma membrane; See PMID 8723646; See PMID 9516239; uncharacterized protein 1080229 4984018 An09g04840 Aspergillus niger uncharacterized protein XP_059601422.1 1077875 D 5061 CDS An09g04850 4984019 join(1080882..1080939,1081127..1081374,1081455..1081658,1081729..1081995) I 1 NT_166525.1 Function: C. testosteroni TsaC is involved in aromatic compound catabolism.; Similarity: C. testosteroni TsaC belongs to the short-chain, zinc-independent dehydrogenases.; Title: strong similarity to p-sulfobenzyl alcohol dehydrogenase TsaC - Comamonas testosteroni; See PMID 9006050; uncharacterized protein 1081995 4984019 An09g04850 Aspergillus niger uncharacterized protein XP_001393798.1 1080882 D 5061 CDS An09g04860 4984020 complement(join(1082163..1082661,1082709..1082944,1082992..1083085,1083137..1083417,1083470..1083765,1083820..1084289,1084340..1084420,1084549..1084589)) I 1 NT_166525.1 Remark: although the predicted A. niger protein shows similarity to several hypothetical and validated transcription factors no DNA-binding motif was predicted.; Title: weak similarity to transcription activator prnA - Aspergillus nidulans; See PMID 9622360; uncharacterized protein 1084589 4984020 An09g04860 Aspergillus niger uncharacterized protein XP_059601423.1 1082163 R 5061 CDS An09g04870 4984021 complement(1085411..1087324) I 1 NT_166525.1 Title: weak similarity to polypeptide SEQ ID NO:6186 from patent WO200153312-A1 - Homo sapiens; uncharacterized protein 1087324 4984021 An09g04870 Aspergillus niger uncharacterized protein XP_001393800.1 1085411 R 5061 CDS An09g04880 4984022 1088549..1089781 I 1 NT_166525.1 hypothetical protein 1089781 4984022 An09g04880 Aspergillus niger hypothetical protein XP_001393801.3 1088549 D 5061 CDS An09g04890 4984023 join(1090124..1090150,1090221..1090869,1090942..1091018) I 1 NT_166525.1 Complex: binding studies and coimmunoprecipitation established that human SNAP-23 binds to syntaxin 6 in vitro and in vivo.; Function: during specific granule secretion in neutrophiles human syntaxin 6 interacts with SNAP-23.; Function: in human neutrophiles syntaxin 6 is involved in exocytosis and acts as a target for secretion of specific and azurophilic granules.; Localization: human syntaxin 6 was reported to localize mainly in the plasma membrane of neutrophiles while in other cell types it localises to the trans-Golgi.; Remark: while References PubMed ID 8663448 and 9243506 describe syntaxin 6 as Golgi specific syntaxin involved in trans-Golgi network vesicle trafficking Referecence 11001914 describes it as plasma membrane associated syntaxin involved in exocytosis of neutrophiles.; Title: similarity to syntaxin 6 - Homo sapiens; See PMID 9243506; See PMID 11001914; See PMID 8663448; uncharacterized protein 1091018 4984023 An09g04890 Aspergillus niger uncharacterized protein XP_059601424.1 1090124 D 5061 CDS An09g04900 4984024 complement(join(1091075..1091184,1091235..1092077,1092208..1092331)) I 1 NT_166525.1 Complex: human SET binds to an HLA class II affinity matrix.; Complex: human SET forms a tripartite complex with PP2A and HRX.; Function: fusion of human SET to CAN (a nuclear pore complex subunit) is common in some forms of leukemia.; Function: human SET is a potent and specific inhibitor of PP2A.; Function: human SET is implicated in tumour relevant signalling events controlling mitosis and/or recognition of tumorous cells.; Title: similarity to inhibitor of PP2A SET - Homo sapiens; nucleus; See PMID 11231286; uncharacterized protein 1092331 4984024 An09g04900 Aspergillus niger uncharacterized protein XP_001393803.1 1091075 R 5061 CDS An09g04910 4984025 complement(join(1094547..1094961,1095023..1095666)) I 1 NT_166525.1 Function: A. nidulans NmrA interacts with the DNA-binding domain and the extreme C terminus of AreA, an activator of nitrogen metabolite gene expression, to inhibit DNA binding under nitrogen sufficient conditions.; Function: A. nidulans NmrA is an inhibitor of the induction of nitrogen metabolite genes.; Title: strong similarity to mediator of nitrogen metabolite repression nmrA - Aspergillus nidulans; See PMID 9106362; See PMID 9537404; See PMID 10471703; uncharacterized protein 1095666 4984025 An09g04910 Aspergillus niger uncharacterized protein XP_001393804.1 1094547 R 5061 CDS An09g04920 84592053 join(1096183..1096239,1096323..1096395,1096751..1096878,1096978..1097148) I 1 NT_166525.1 hypothetical protein 1097148 84592053 An09g04920 Aspergillus niger hypothetical protein XP_059601425.1 1096183 D 5061 CDS An09g04940 10098035 1098414..1100057 I 1 NT_166525.1 Title: strong similarity to transposase of Tan1 -Aspergillus niger; See PMID 9003286; uncharacterized protein 1100057 10098035 An09g04940 Aspergillus niger uncharacterized protein XP_059601426.1 1098414 D 5061 CDS An09g04950 4984028 complement(join(1100905..1101047,1101368..1101653,1101725..1102089,1102158..1103145)) I 1 NT_166525.1 Catalytic activity: lysophospholipases 2-lysophosphatidylcholine + H(2)O to glycerophosphocholine + a fatty acid anion.; Complex: rat lysophospholipase-transacylase exists as a monomer.; Function: rat lysophospholipase-transacylase catalyzes not only the hydrolysis of 1-acyl-sn-glycero-3-phosphocholine, but also the transfer of its acyl chain to a second molecule of 1-acyl-sn-glycero-3-phosphocholine to form phosphatidylcholine.; Function: rat lysophospholipase-transacylase is involved in fatty acid remodeling of phospholipids.; Remark: rat lysophospholipase-transacylase is selective for choline lysophospholipid, ethanolamine,inositol, and serine lysophospholipids were not good substrates.; Repression: for rat lysophospholipase-transacylase phosphatidic acid was a potent competitive inhibitor, less potent were lysophosphatidic acid, palmitoyl-L-carnitine,and fatty acid.; Title: strong similarity to lysophospholipase-transacylase - Rattus norvegicus; See PMID 9276665; See PMID 9575212; See PMID 10320809; See PMID 8119970; uncharacterized protein 1103145 4984028 An09g04950 Aspergillus niger uncharacterized protein XP_001393807.3 1100905 R 5061 CDS An09g04960 84592054 join(1104014..1104049,1104108..1104515,1104916..1105179,1105254..1105319,1105383..1105631) I 1 NT_166525.1 Complex: cdc2 forms a complex with cyclin B.; Function: cdc2 kinase governs M phase, controls the onset of S phase and, in addition, ensures that there is only one S-phase per cell cycle.; Localization: nuclear translocation of the cyclinB/cdc2 complex is executed specifically at the onset of M-phase.; Title: similarity to cyclin dependent kinase cdc2 -Zea mays; deleted EC_number 2.7.1.37; See PMID 8855663; See PMID 9552419; See PMID 11063929; See PMID 2014258; uncharacterized protein 1105631 84592054 An09g04960 Aspergillus niger uncharacterized protein XP_059601427.1 1104014 D 5061 CDS An09g04970 4984030 complement(join(1105726..1106243,1106315..1106753)) I 1 NT_166525.1 Function: Bcl-3, p50, and Pirin are sequestered into quarternary complexes on NF-kappaB DNA binding sites,thereby modulating NF-kappaB driven gene expression.; Function: human Pirin likely acts as cofactor of transcriptional regulators.; Function: human Pirin was isolated by a yeast two-hybrid screen as an interactor of nuclear factor I/CCAAT box transcription factor (NFI/CTF1).; Function: using the yeast two-hybrid-system Pirin was identified as Bcl-3 interacting protein.; Localization: confocal immunofluorescence experiments demonstrate a predominant localization of human Pirin within dot-like subnuclear structures.; Title: similarity to transcription cofactor Pirin -Homo sapiens; nucleus; See PMID 9079676; See PMID 10362352; uncharacterized protein 1106753 4984030 An09g04970 Aspergillus niger uncharacterized protein XP_001393809.3 1105726 R 5061 CDS An09g04980 4984031 complement(join(1107180..1108803,1108861..1108925)) I 1 NT_166525.1 Title: weak similarity to zinc binuclear cluster protein sequence #33 from patent WO200224865-A2 -Unclassified organism; nucleus; uncharacterized protein 1108925 4984031 An09g04980 Aspergillus niger uncharacterized protein XP_001393810.1 1107180 R 5061 CDS An09g04990 4984032 join(1110621..1110905,1110962..1111084,1111187..1111339,1111400..1112254,1112315..1112381,1112433..1112572) I 1 NT_166525.1 Catalytic activity: acetamidases catalyze the conversion of a Monocarboxylic acid amide + H(2)O to a Monocarboxylate + NH3.; Function: A. nidulans amdS hydrolyses acetamide to acetate and ammonium thus providing a source of carbon and nitrogen.; Regulation: regulation of A. nidulans amdS is complex and involves multiple regulatory transcription factors like amdR and amdX.; Title: strong similarity to acetamidase amdS -Aspergillus nidulans; See PMID 9044292; See PMID 3036667; See PMID 7847883; uncharacterized protein 1112572 4984032 An09g04990 Aspergillus niger uncharacterized protein XP_001393811.1 1110621 D 5061 CDS An09g05000 4984033 join(1113436..1113491,1113565..1114234) I 1 NT_166525.1 Similarity: similarity is from the N-terminal region of the predicted A. niger protein to the N-terminal region of human IPP, which is equivalent to the BTB/POZ/kelch domain.; Title: weak similarity to actin-binding protein IPP - Homo sapiens; See PMID 10072760; uncharacterized protein 1114234 4984033 An09g05000 Aspergillus niger uncharacterized protein XP_001393812.1 1113436 D 5061 CDS An09g05010 4984034 complement(join(1115625..1115749,1115808..1116745,1116827..1117320)) I 1 NT_166525.1 Function: S. cerevisiae HNM1 mediates the import of choline, ethanolamine, nitrogen mustard and nitrogen half mustard.; Regulation: expression of S. cerevisiae HNM1 in wild-type cells is only regulated by the phospholipid precursors inositol and choline via the phospholipid regulatory genes INO2, INO4, and OPI1.; Remark: an alternative name for S. cerevisiae HNM1 is CTR.; Title: strong similarity to choline permease Hnm1 -Saccharomyces cerevisiae; plasma membrane; See PMID 2203793; See PMID 8264542; uncharacterized protein 1117320 4984034 An09g05010 Aspergillus niger uncharacterized protein XP_001393813.1 1115625 R 5061 CDS An09g05020 84592055 join(1117524..1117601,1117651..1117868,1118137..1118272) I 1 NT_166525.1 hypothetical protein 1118272 84592055 An09g05020 Aspergillus niger hypothetical protein XP_059601428.1 1117524 D 5061 CDS An09g05030 84592056 complement(join(1121174..1121255,1121305..1121503,1121618..1121702)) I 1 NT_166525.1 hypothetical protein 1121702 84592056 An09g05030 Aspergillus niger hypothetical protein XP_059601429.1 1121174 R 5061 CDS An09g05040 4984037 join(1123349..1123400,1123459..1123615,1123670..1124957) I 1 NT_166525.1 Title: similarity to hypothetical protein B1D4.110 -Neurospora crassa; uncharacterized protein 1124957 4984037 An09g05040 Aspergillus niger uncharacterized protein XP_059601430.1 1123349 D 5061 CDS An09g05050 84592057 complement(join(1125263..1125319,1125487..1125552,1125639..1125719)) I 1 NT_166525.1 Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1125719 84592057 An09g05050 Aspergillus niger uncharacterized protein XP_059601431.1 1125263 R 5061 CDS An09g05060 4984039 1127767..1129452 I 1 NT_166525.1 Function: Rdr1 from S. cerevisiae is a transcriptional repressor of five genes (including Pdr5 an efflux pump that confers multidrug resistance).; Function: deletion of RDR1 in S. cerevisiae results in an increased resistance to cycloheximide.; Title: strong similarity to transcription repressor Rdr1 - Saccharomyces cerevisiae; See PMID 11882665; uncharacterized protein 1129452 4984039 An09g05060 Aspergillus niger uncharacterized protein XP_001393818.1 1127767 D 5061 CDS An09g05070 4984040 1129719..1131476 I 1 NT_166525.1 Function: expression of C. albicans Flu1 mediated not only resistance to fluconazole but also to cycloheximide.; Similarity: FLU1 of C. albicans is a member of the major falicitator superfamily.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353; uncharacterized protein 1131476 4984040 An09g05070 Aspergillus niger uncharacterized protein XP_001393819.3 1129719 D 5061 CDS An09g05080 4984041 join(1132811..1132946,1133045..1133107,1133189..1133627,1133695..1133811,1133899..1134769) I 1 NT_166525.1 Catalytic activity: tyrosine/phenylalanine aminotransferases convert L-tyrosine/L-phenylalanine + 2-oxoglutarate to 4-hydroxyphenylpyruvate + L-glutamate.; Function: S. cerevisiae ARO8 is active not only with the aromatic amino acids, but also with methionine,alpha-aminoadipate, and leucine when phenylpyruvate is the amino acceptor, and in the reverse reactions with their oxo-acid analogues and phenylalanine as the amino donor.; Function: S. cerevisiae ARO8 is specialised for aromatic amino acid and alpha-aminoadipate transamination.; Function: S. cerevisiae ARO8 may be able to play a role in several otherwise unrelated metabolic pathways.; Function: S. cerevisiae aro8 and aro9 (aromatic aminotransferase I+II) double mutants are auxotrophic for both phenylalanine and tyrosine, while neither of the single mutants displays any nutritional requirement.; Regulation: S. cerevisiae ARO8 expression is subject to the general control of amino acid biosynthesis.; Remark: the systematic name for S. cerevisiae ARO8 is YGL202w.; Similarity: S. cerevisiae ARO8 is a member of the aminotransferase subgroup I.; Title: similarity to aromatic aminotransferase I Aro8 - Saccharomyces cerevisiae; See PMID 9491083; See PMID 9491082; uncharacterized protein 1134769 4984041 An09g05080 Aspergillus niger uncharacterized protein XP_059601432.1 1132811 D 5061 CDS An09g05100 4984043 join(1135224..1135728,1135798..1136351) I 1 NT_166525.1 Title: similarity to Impact - Mus musculus; See PMID 11116084; uncharacterized protein 1136351 4984043 An09g05100 Aspergillus niger uncharacterized protein XP_059601433.1 1135224 D 5061 CDS An09g05110 4984044 complement(join(1137281..1137652,1137714..1137984,1138041..1139200,1139268..1139629,1139693..1140146,1140251..1140382)) I 1 NT_166525.1 Function: M. aeruginosa McyG is involved in synthesis of the peptide-polyketide microcystin.; Title: strong similarity to peptide-polyketide synthase McyG - Microcystis aeruginosa; See PMID 11033079; uncharacterized protein 1140382 4984044 An09g05110 Aspergillus niger uncharacterized protein XP_059601434.1 1137281 R 5061 CDS An09g05120 4984045 complement(1141728..1143245) I 1 NT_166525.1 Catalytic activity: triacylglycerol lipases convert triacylglycerol + H(2)O to diacylglycerol + a fatty acid anion.; Title: similarity to lipase lip1 - Geotrichum candidum; See PMID 8370674; uncharacterized protein 1143245 4984045 An09g05120 Aspergillus niger uncharacterized protein XP_001393823.3 1141728 R 5061 CDS An09g05130 4984046 complement(join(1144315..1145118,1145178..1145349,1145418..1145626)) I 1 NT_166525.1 Catalytic activity: monophenol monooxygenases convert L-tyrosine + L-DOPA + O(2) to L-DOPA + DOPAquinone + H(2)O.; Complex: S. antibioticus MelC1 protein is involved in the transfer of copper ion to apotyrosinase MelC2 via binary complex formation.; Function: S. antibioticus tyrosinase melC2 is responsible for melanin synthesis.; Localization: most of the tyrosinase activity was secreted during growth of S. antibioticus.; Regulation: S. antibioticus MelC1 is required for activation and secretion of MelC2.; Title: similarity to monophenol monooxygenase melC2 - Streptomyces antibioticus; extracellular/secretion proteins; See PMID 1400329; See PMID 3932128; uncharacterized protein 1145626 4984046 An09g05130 Aspergillus niger uncharacterized protein XP_001393824.1 1144315 R 5061 CDS An09g05140 4984047 join(1146182..1146253,1146317..1147255) I 1 NT_166525.1 Similarity: the predicted A. niger protein shows weak similarity to several dehydrogenases and contains dehydrogenase motifs.; Title: strong similarity to hypothetical protein cipA - Aspergillus nidulans; uncharacterized protein 1147255 4984047 An09g05140 Aspergillus niger uncharacterized protein XP_001393825.1 1146182 D 5061 CDS An09g05150 4984048 join(1147679..1147730,1147787..1148169,1148271..1148355,1148478..1148566,1148625..1148841,1148910..1148989,1149051..1149096,1149178..1149209) I 1 NT_166525.1 Title: similarity to protein fragment SEQ ID NO:3767 from patent EP1108790-A2 - Corynebacterium glutamicum; uncharacterized protein 1149209 4984048 An09g05150 Aspergillus niger uncharacterized protein XP_059601435.1 1147679 D 5061 CDS An09g05160 84592058 join(1150767..1151064,1151146..1151232,1151316..1151546,1151641..1151823,1151889..1152034) I 1 NT_166525.1 Function: S. cerevisiae SCS3 is involved in phospholipid metabolism.; Function: S. cerevisiae SCS3 is involved in the synthesis of inositol phospholipids from inositol but not in the control of inositol synthesis.; Title: weak similarity to protein required for inositol prototrophy Scs3 - Saccharomyces cerevisiae; See PMID 7706223; uncharacterized protein 1152034 84592058 An09g05160 Aspergillus niger uncharacterized protein XP_059601436.1 1150767 D 5061 CDS An09g05170 4984050 1152989..1154218 I 1 NT_166525.1 Title: similarity to hypothetical protein 15E11.110 - Neurospora crassa; uncharacterized protein 1154218 4984050 An09g05170 Aspergillus niger uncharacterized protein XP_001393828.1 1152989 D 5061 CDS An09g05180 4984051 join(1154917..1155026,1155123..1155217,1155295..1155445,1155519..1156281) I 1 NT_166525.1 Remark: L4 of S. cerevisiae is also called L2A, RP2,RPL4A, RPL2A, RPL2, YBR031W or YBR0315.; Remark: in S. cerevisiae, the genes coding for the ribosomal protein L4 are present in two copies per haploid genome.; Remark: the ORF is longer than L4 of S. cerevisiae (457 compared to 361 amino acids).; Remark: the amino acid sequence shows also strong similarity to many other L4 ribosomal proteins of different organisms.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L4 - Saccharomyces cerevisiae; cytoplasm; See PMID 1544921; See PMID 3062369; 60S ribosomal protein uL4 1156281 4984051 An09g05180 Aspergillus niger 60S ribosomal protein uL4 XP_001393829.3 1154917 D 5061 CDS An09g05200 4984052 join(1165860..1166572,1166775..1166806,1166848..1167794,1167856..1168896) I 1 NT_166525.1 Title: similarity to hypothetical transcription regulator SPAC18G6.01c - Schizosaccharomyces pombe; uncharacterized protein 1168896 4984052 An09g05200 Aspergillus niger uncharacterized protein XP_059601437.1 1165860 D 5061 CDS An09g05210 4984054 join(1169888..1170319,1170433..>1170768) I 1 NT_166525.1 Remark: C-terminal truncated ORF due to end of contig.; Title: similarity to hypothetical protein encoded by ORF NT2RP3001426 - Homo sapiens [truncated ORF]; uncharacterized protein 1170768 4984054 An09g05210 Aspergillus niger uncharacterized protein XP_001393832.3 1169888 D 5061 CDS An09g05220 84592059 join(<1170912..1170998,1171071..1172204) I 1 NT_166525.1 Function: putatively involved in heat shock response.; Remark: truncated ORF due to contig border.; Title: weak similarity to chaperone protein 6 (HCHP-6) from patent WO200017358-A2 - Homo sapiens [truncated ORF]; uncharacterized protein 1172204 84592059 An09g05220 Aspergillus niger uncharacterized protein XP_059601438.1 1170912 D 5061 CDS An09g05230 4984055 join(1172727..1172873,1172976..1174403,1174471..1174638) I 1 NT_166525.1 Function: Skip is highly homologous to the Drosophila melanogaster protein Bx42 which is found associated with chromatin in transcriptionally active puffs of salivary glands.; Remark: Skip from H. sapiens is also known as SNW1.; Title: strong similarity to nuclear protein Skip -Homo sapiens; nucleus; See PMID 9569025; uncharacterized protein 1174638 4984055 An09g05230 Aspergillus niger uncharacterized protein XP_001393833.1 1172727 D 5061 CDS An09g05240 4984056 join(1178263..1178310,1178438..1178826,1178880..1179858) I 1 NT_166525.1 Title: strong similarity to hypothetical protein CAE76169.1 - Neurospora crassa; uncharacterized protein 1179858 4984056 An09g05240 Aspergillus niger uncharacterized protein XP_001393834.1 1178263 D 5061 CDS An09g05250 4984057 complement(join(1181518..1181582,1181670..1182269,1182337..1182675,1182735..1182792)) I 1 NT_166525.1 Similarity: shows strong similarity to WD domain (G-beta repeat) resulting in variing similarities to proteins containing such domains.; Title: strong similarity to hypothetical protein MVP7.5 - Arabidopsis thaliana; uncharacterized protein 1182792 4984057 An09g05250 Aspergillus niger uncharacterized protein XP_059601439.1 1181518 R 5061 CDS An09g05260 4984058 complement(join(1183372..1183441,1183494..1184002,1184066..1184376,1184444..1184606,1184667..1184709,1184766..1184779,1184851..1184892)) I 1 NT_166525.1 Function: CDC12 of S. cerevisiae is involved in proper bud growth and cytokinesis.; Function: it is required for control of bud growth during mitosis.; Function: it is required for mitosis-specific activation of Gin4p.; Function: it is required for pheromone-induced morphogenesis.; Function: it is required for proper localization of Afr1p.; Title: strong similarity to cell division control protein Cdc12 - Saccharomyces cerevisiae; cytoskeleton; See PMID 9201710; See PMID 9813092; uncharacterized protein 1184892 4984058 An09g05260 Aspergillus niger uncharacterized protein XP_001393836.1 1183372 R 5061 CDS An09g05270 4984059 join(1185464..1185481,1185583..1185695,1185764..1186259,1186307..1186554,1186603..1188439) I 1 NT_166525.1 Function: Pwp2p exists in a proteinaceous complex,possibly associated with the cytoskeleton, where it functions in control of cell growth and separation.; Function: it is required for bud-site selection and cell separation.; Localization: HA-Pwp2p of S. cerevisiae was clustered at multiple points in the cytoplasm, probably associates with the cytoskeleton.; Similarity: shows weaker similarity at the carboxyterminus.; Title: strong similarity to periodic tryptophan protein Pwp2 - Saccharomyces cerevisiae; cytoplasm; uncharacterized protein 1188439 4984059 An09g05270 Aspergillus niger uncharacterized protein XP_001393837.1 1185464 D 5061 CDS An09g05280 4984060 complement(join(1189075..1189122,1189213..1189718,1189889..1189919,1189955..1189976,1190026..1190279)) I 1 NT_166525.1 Similarity: the ORF encoded protein shows also weak similarity to putative polyketide cyclase snoaM from Streptomyces nogalater.; Title: strong similarity to hypothetical protein CAD27299.1 - Aspergillus fumigatus; uncharacterized protein 1190279 4984060 An09g05280 Aspergillus niger uncharacterized protein XP_059601440.1 1189075 R 5061 CDS An09g05290 4984061 complement(join(1190688..1193221,1193273..1194959)) I 1 NT_166525.1 Function: exonuclease II (ExoII) from S. pombe is a 5'-->3' single-stranded DNA exonuclease.; Function: it is involved in DNA and/or RNA metabolism in vivo.; Similarity: ExoII is a homologue of the multifunctional S. cerevisiae Sep1 protein.; Title: strong similarity to exonuclease II SPAC17A5.14 - Schizosaccharomyces pombe; nucleus; See PMID 8188690; See PMID 8781170; uncharacterized protein 1194959 4984061 An09g05290 Aspergillus niger uncharacterized protein XP_001393839.1 1190688 R 5061 CDS An09g05300 4984062 join(1195627..1195645,1195705..1195767,1195824..1195929,1195980..1196441,1196498..1196983,1197037..1197211) I 1 NT_166525.1 Function: RbAp48 and RbAp46 may have shared as well as unique functions in the regulation of cell proliferation and differentiation.; Function: the retinoblastoma protein (Rb) interacts with multiple cellular proteins that mediate its cellular function.; Similarity: shows strong similarity to first 400 aa and almost no similarity at the carboxyterminus.; Title: strong similarity to G1/S transition control protein-binding protein RbAp48 - Mus musculus; See PMID 7503932; uncharacterized protein 1197211 4984062 An09g05300 Aspergillus niger uncharacterized protein XP_001393840.1 1195627 D 5061 CDS An09g05310 4984063 join(1198215..1198420,1198474..1198607,1198665..1198969,1199028..1199330) I 1 NT_166525.1 Function: catalyzes synthesis of D-erythro-7,8-dihydroneopterintriphosphate from GTP.; Pathway: tetrahydrofolate pathway, GTP cyclohydrolase I catalyses the first step in biosynthesis of tetrahydrofolate in prokaryotes and of tetrahydrobiopterin in vertebrates.; Similarity: GTP cyclohydrolase seem to be conserved among the species but less conserved at the aminoterminus.; Similarity: Nevertheless it is possible that the ORF is too long at the aminoterminus, perhapes alternative splicing exists (human).; Title: strong similarity to GTP cyclohydrolase I Fol2 - Saccharomyces cerevisiae; See PMID 10049741; See PMID 8573145; uncharacterized protein 1199330 4984063 An09g05310 Aspergillus niger uncharacterized protein XP_001393841.3 1198215 D 5061 CDS An09g05320 4984064 join(1200565..1200723,1200760..1202934) I 1 NT_166525.1 Title: similarity to hypothetical protein EAA59211.1 - Aspergillus nidulans; uncharacterized protein 1202934 4984064 An09g05320 Aspergillus niger uncharacterized protein XP_059601441.1 1200565 D 5061 CDS An09g05330 4984065 complement(join(1204089..1204277,1204340..1204684)) I 1 NT_166525.1 Title: similarity to hypothetical protein 4MeS -Metarhizium anisopliae; uncharacterized protein 1204684 4984065 An09g05330 Aspergillus niger uncharacterized protein XP_001393843.1 1204089 R 5061 CDS An09g05340 4984066 join(<1205378..1205856,1205921..1206446,1206492..1206615,1206680..1206792,1206850..1207294,1207369..1207800,1207873..1210010,1210064..1210160,1210216..1210241,1210294..1211160,1211214..1211495,1211556..1211630,1211689..1212026,1212079..1212556,1212607..1213500) I 1 NT_166525.1 Remark: FUM5 is a PKS gene required for fumonisin biosynthesis.; Remark: biochemical analyses indicate that fumonisins are a product of either polyketide or fatty acid biosynthesis.; Remark: the ORF is N-terminally truncated due to contig border.; Title: strong similarity to polyketide synthase FUM5 - Gibberella moniliformis; See PMID 10413619; See PMID 10872449; uncharacterized protein 1213500 4984066 An09g05340 Aspergillus niger uncharacterized protein XP_059606944.1 1205378 D 5061 CDS An09g05350 4984067 complement(1214058..1215668) I 1 NT_166525.1 Catalytic activity: Penicillin + H2O = a Carboxylate + 6-Aminopenicillanate.; Remark: PVA is used for the enzymatic hydrolysis of penicillin V (phenoxy-methylpenicillin) to 6-aminopenicillanic acid (6-APA). 6-APA is the active beta-lactam nucleus used in the manufacture of semi-synthetic penicillins.; Remark: similar to patent US5516679-A.; Title: strong similarity to mature penicillin V amidohydrolase PVA from patent US5516679-A - Fusarium oxysporum; uncharacterized protein 1215668 4984067 An09g05350 Aspergillus niger uncharacterized protein XP_001393845.1 1214058 R 5061 CDS An09g05360 4984068 complement(join(1217715..1217920,1218091..1218556)) I 1 NT_166525.1 Catalytic activity: dCTP + H2O = dUTP + NH3.; Pathway: pyrimidine metabolism; Similarity: to many dCTP deaminases.; Title: similarity to hypothetical dCTP deaminase AF1108 - Archaeoglobus fulgidus; uncharacterized protein 1218556 4984068 An09g05360 Aspergillus niger uncharacterized protein XP_001393846.3 1217715 R 5061 CDS An09g05370 4984069 join(1221659..1222812,1222877..1224751,1224804..1225011) I 1 NT_166525.1 Catalytic activity: ATP + a protein = ADP + a phosphoprotein.; Remark: kinases of the CDC2 family play a key role in cell cycle regulation and gene expression.; Remark: the human cDNA encodes the full-length amino acid sequence of the cholinesterase-related cell division controller (CHED) kinase.; Title: strong similarity to protein kinase isoform 1 of CDC2L5 - Homo sapiens; deleted EC_number 2.7.1.37; See PMID 11125699; See PMID 11162436; uncharacterized protein 1225011 4984069 An09g05370 Aspergillus niger uncharacterized protein XP_001393847.3 1221659 D 5061 CDS An09g05380 4984070 join(1226872..1227602,1227667..1227937) I 1 NT_166525.1 Remark: Patent: WO9943820-A1.; Remark: the zea mays sequence represents a plant translation factor designated eIF-4E. eIF-4E is a translation factor which binds to a m^7G cap-binding protein. The eIF-4E nucleotide sequence may be used to control protein synthesis in plants.; Title: strong similarity to eIF-4E protein from patent WO9943820-A1 - Zea mays; uncharacterized protein 1227937 4984070 An09g05380 Aspergillus niger uncharacterized protein XP_001393848.3 1226872 D 5061 CDS An09g05390 84592060 join(1228857..1228892,1229036..1229110) I 1 NT_166525.1 Remark: questionable genestructure, large intron and only 36 aa protein predicted.; Title: questionable ORF; uncharacterized protein 1229110 84592060 An09g05390 Aspergillus niger uncharacterized protein XP_059606945.1 1228857 D 5061 CDS An09g05400 4984072 join(1229930..1230142,1230259..1230365,1230425..1230505,1230570..1230627,1230687..1231873,1231984..1232385,1232442..1232507,1232558..1232875,1232906..1234202) I 1 NT_166525.1 Remark: SUSP1 is a cysteine protease containing the well conserved His/Asp/Cys catalytic triad.; Remark: reproductive organs, such as testis, ovary,and prostate, contained much higher amounts of SUSP1 mRNA than colon and peripheral blood leukocyte, whereas other tissues, such as heart and spleen, had little or none.; Title: strong similarity to SUMO-1-specific protease SSP1 - Homo sapiens; See PMID 10799485; uncharacterized protein 1234202 4984072 An09g05400 Aspergillus niger uncharacterized protein XP_059606946.1 1229930 D 5061 CDS An09g05410 4984073 complement(join(1234494..1234845,1234927..1235045)) I 1 NT_166525.1 Remark: AIG1 and AIG2 (for avrRpt2-induced gene),exhibit RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2.; Remark: the induction patterns of the AIG genes and ELI3 demonstrate that different resistance gene-avr gene combinations can elicit distinct defense responses.; Title: similarity to avrRpt2-induced protein AIG2 -Arabidopsis thaliana; See PMID 8742710; uncharacterized protein 1235045 4984073 An09g05410 Aspergillus niger uncharacterized protein XP_059606947.1 1234494 R 5061 CDS An09g05420 4984074 join(1235669..1235814,1235943..1236016,1236115..1236641) I 1 NT_166525.1 Remark: alternative name for SPC3 is YLR066w.; Remark: it is shown that Spc3p is required for cell growth and signal peptidase activity within the yeast endoplasmic reticulum.; Similarity: to many eukaryotic signal peptidases.; Title: similarity to signal peptidase subunit Spc3 -Saccharomyces cerevisiae; See PMID 9148930; See PMID 8910564; uncharacterized protein 1236641 4984074 An09g05420 Aspergillus niger uncharacterized protein XP_001393852.1 1235669 D 5061 CDS An09g05430 10098036 complement(join(1236742..1236794,1236983..1237120,1237266..1237277,1237350..1237398)) I 1 NT_166525.1 Title: weak similarity to hypothetical mucin-like protein EMUCt-2 - Trypanosoma cruzi; See PMID 9556557; uncharacterized protein 1237398 10098036 An09g05430 Aspergillus niger uncharacterized protein XP_059606948.1 1236742 R 5061 CDS An09g05440 84592061 join(1237549..1237677,1237735..1237935) I 1 NT_166525.1 hypothetical protein 1237935 84592061 An09g05440 Aspergillus niger hypothetical protein XP_059606949.1 1237549 D 5061 CDS An09g05460 4984077 complement(join(1238050..1238841,1238899..1239181,1239241..1239350,1239429..1239539)) I 1 NT_166525.1 Catalytic activity: ATP + [pyruvate dehydrogenase (lipoamide)] = ADP + [pyruvate dehydrogenase (lipoamide)] phosphate.; Remark: pyruvate dehydrogenase kinase in Arabidopsis functions as negative regulator of the mitochondrial pyruvate dehydrogenase complex.; Title: strong similarity to pyruvate dehydrogenase (lipoamide) kinase PDK - Arabidopsis thaliana; localisation:mitochondrion; See PMID 10737148; uncharacterized protein 1239539 4984077 An09g05460 Aspergillus niger uncharacterized protein XP_059606950.1 1238050 R 5061 CDS An09g05470 84592062 join(1239564..1239649,1239762..1239854,1240205..1240279,1240446..1240515,1240693..1240923) I 1 NT_166525.1 Remark: questionable genestructure.; hypothetical protein 1240923 84592062 An09g05470 Aspergillus niger hypothetical protein XP_059606951.1 1239564 D 5061 CDS An09g05480 4984079 join(1241025..1241033,1241144..1241264,1241444..1241588,1241647..1241804,1241871..1242060,1242111..1242219,1242272..1243220,1243273..1244405,1244466..1244780,1244834..1244963,1245024..1245079,1245211..1245363) I 1 NT_166525.1 Catalytic activity: ubiquitin C-terminal thiolester + H(2)O <=> ubiquitin + a thiol.; Complex: HAUSP of H. sapiens is a subset of ND10.; Function: HAUSP of H. sapiens is an ubiquitin-specific protease.; Remark: HAUSP of H. sapiens is also called USP7.; Remark: HAUSP of H. sapiens is strongly bound by Vmv110, a Herpes simplex virus type 1 immediate-early protein, which induces the proteasome-dependent degradation of the catalytic subunit of DNA-dependent protein kinase.; Remark: ND10 constitutes nuclear bodies.; Remark: ubiquitin-specific proteases (UBPs) are a family of unique hydrolases that specifically remove polypeptides covalently linked via peptide or isopeptide bonds to the C-terminal glycine of ubiquitin.; Title: strong similarity to ubiquitin specific protease HAUSP - Homo sapiens; See PMID 9428630; See PMID 9658103; See PMID 9847347; See PMID 9130697; uncharacterized protein 1245363 4984079 An09g05480 Aspergillus niger uncharacterized protein XP_001393857.3 1241025 D 5061 CDS An09g05490 4984080 join(1245838..1245990,1246067..1246255,1246385..1246762) I 1 NT_166525.1 Function: receptors for cargo proteins that are transported by COP I - (coat protein I) and/or COP II-coated vesicles between the endoplasmic reticulum and the Golgi complex in Polysphondylium pallidum.; Title: strong similarity to COP-coated vesicle membrane protein P24 homolog lbrA - Polysphondylium pallidum; See PMID 10571036; uncharacterized protein 1246762 4984080 An09g05490 Aspergillus niger uncharacterized protein XP_001393858.3 1245838 D 5061 CDS An09g05500 84592063 join(1246974..1247029,1247140..1247555,1247955..1248063,1248170..1248323,1248501..1248704,1248792..1248946,1249039..1249171) I 1 NT_166525.1 Remark: protein shows weak similarities to motifs of RNA-polymerase subunits.; hypothetical protein 1249171 84592063 An09g05500 Aspergillus niger hypothetical protein XP_059606952.1 1246974 D 5061 CDS An09g05510 84592064 complement(join(1249206..1249793,1250275..1250352)) I 1 NT_166525.1 Remark: blast hits include a repetitive sequence (poly G).; Remark: questionable genestructure because of a large intron.; Title: weak similarity to hypothetical protein Y51H1A.4 - Caenorhabditis elegans; uncharacterized protein 1250352 84592064 An09g05510 Aspergillus niger uncharacterized protein XP_059606953.1 1249206 R 5061 CDS An09g05520 84592065 1250382..1250741 I 1 NT_166525.1 Remark: the ORF is short in length.; hypothetical protein 1250741 84592065 An09g05520 Aspergillus niger hypothetical protein XP_059606954.1 1250382 D 5061 CDS An09g05530 4984084 join(1251836..1252178,1252276..1252349,1252449..1252640) I 1 NT_166525.1 hypothetical protein 1252640 4984084 An09g05530 Aspergillus niger hypothetical protein XP_001393862.1 1251836 D 5061 CDS An09g05540 4984085 complement(join(1252868..1254454,1254534..1254683)) I 1 NT_166525.1 Remark: the ORF shows strong and highly specific similarity to the N. crassa protein. Additionally, the ORF shows some unspecific similarity to other proteins due to it's proline-rich sequence.; Title: strong similarity to hypothetical protein encoded by gene B18D24.90 - Neurospora crassa; uncharacterized protein 1254683 4984085 An09g05540 Aspergillus niger uncharacterized protein XP_001393863.1 1252868 R 5061 CDS An09g05550 4984086 complement(join(1255272..1255706,1255768..1255907,1255961..1256029,1256082..1257104,1257164..1257368)) I 1 NT_166525.1 Similarity: the ORF shows unspecific similarity to some proteins due to it's serine-rich sequence.; Title: weak similarity to hypothetical protein EAA53565.1 - Magnaporthe grisea; uncharacterized protein 1257368 4984086 An09g05550 Aspergillus niger uncharacterized protein XP_001393864.1 1255272 R 5061 CDS An09g05560 84592066 join(1257461..1257506,1257608..1257777) I 1 NT_166525.1 hypothetical protein 1257777 84592066 An09g05560 Aspergillus niger hypothetical protein XP_059606955.1 1257461 D 5061 CDS An09g05570 84592067 complement(join(1257861..1257953,1258057..1258239,1258296..1258388,1258502..1258739,1258901..1259105,1259260..1259486,1259562..1259688,1259782..1259812)) I 1 NT_166525.1 Title: weak similarity to Recq helicase 5 RecQ5 -Drosophila melanogaster; uncharacterized protein 1259812 84592067 An09g05570 Aspergillus niger uncharacterized protein XP_059606956.1 1257861 R 5061 CDS An09g05580 4984089 complement(join(1260495..1260924,1260988..1261571,1261654..1261760,1261811..1262036)) I 1 NT_166525.1 Remark: lactate transport across cell membranes is mediated by a family of proton-coupled monocarboxylate transporters (MCTs).; Title: strong similarity to monocarboxylate transporter MCT3 - Homo sapiens; See PMID 9425115; See PMID 10493836; See PMID 11005765; uncharacterized protein 1262036 4984089 An09g05580 Aspergillus niger uncharacterized protein XP_001393867.3 1260495 R 5061 CDS An09g05590 4984090 join(1262378..1262502,1262700..1263554,1263614..1264619) I 1 NT_166525.1 Remark: the zinc finger of the S. pombe protein is not part of the homologous region between the two proteins.; Similarity: the ORF encoded protein shows also weak similarity to hypothetical transcriptional regulatory protein SPAC1F7. 11C from Schizosaccharomyces pombe.; Similarity: the ORF is about 100 amino acids shorter than the S. pombe protein and the homologie spans the central part of both proteins.; Title: weak similarity to zinc binuclear cluster protein sequence #108 from patent WO200224865-A2 -Unclassified organism; uncharacterized protein 1264619 4984090 An09g05590 Aspergillus niger uncharacterized protein XP_001393868.3 1262378 D 5061 CDS An09g05600 4984091 complement(join(1265538..1267547,1267607..1267804,1267897..1268127)) I 1 NT_166525.1 Title: similarity to hypothetical protein CAD11369.1 - Neurospora crassa; uncharacterized protein 1268127 4984091 An09g05600 Aspergillus niger uncharacterized protein XP_059606957.1 1265538 R 5061 CDS An09g05610 4984092 complement(join(1268924..1270759,1270806..1271171)) I 1 NT_166525.1 Function: in N. crassa, the fusion of hyphae of opposite mating type during vegetative growth results in growth inhibition and cell death, a process that is mediated by the tol locus.; Regulation: tol transcription is repressed to allow the coexistence of opposite mating-type nuclei during the sexual reproductive phase.; Remark: mutations in tol are recessive and suppress mating-type-associated heterokaryon incompatibility.; Title: similarity to vegetative incompatibility protein tol - Neurospora crassa; See PMID 9449795; See PMID 9927450; uncharacterized protein 1271171 4984092 An09g05610 Aspergillus niger uncharacterized protein XP_059606958.1 1268924 R 5061 CDS An09g05620 84592068 complement(1272339..1272797) I 1 NT_166525.1 Title: weak similarity to hypothetical protein encoded by An04g05450 - Aspergillus niger; uncharacterized protein 1272797 84592068 An09g05620 Aspergillus niger uncharacterized protein XP_059606959.1 1272339 R 5061 CDS An09g05625 4984094 join(1275010..1275197,1275262..1275295) I 1 NT_166525.1 Title: similarity to EST SEQ ID NO:6052 from patent WO200056762-A2 - Aspergillus oryzae; uncharacterized protein 1275295 4984094 An09g05625 Aspergillus niger uncharacterized protein XP_001393872.1 1275010 D 5061 CDS An09g05630 4984095 complement(join(1276130..1276473,1276536..1276561,1276652..1276665,1276735..1276743)) I 1 NT_166525.1 Similarity: the ORF overlaps with the A. niger EST NO:4130.; Title: strong similarity to hypothetical protein encoded by gene B18D24.80 - Neurospora crassa; uncharacterized protein 1276743 4984095 An09g05630 Aspergillus niger uncharacterized protein XP_001393873.1 1276130 R 5061 CDS An09g05640 4984096 join(1277241..1277376,1277439..1279759) I 1 NT_166525.1 Alternative name: SSL2, LOM3, YIL143C.; Function: RAD25 is a DEAD/H box-containing helicase,which is required for promoter escape in vivo.; Function: S. cerevisiae RAD25 is required for nucleotide excision repair in RNA polymerase II transcription.; Title: strong similarity to subunit of transcription initation factor TFIIH DNA helicase Rad25 - Saccharomyces cerevisiae; nucleus; See PMID 10713451; See PMID 7891722; uncharacterized protein 1279759 4984096 An09g05640 Aspergillus niger uncharacterized protein XP_001393874.1 1277241 D 5061 CDS An09g05650 4984097 join(1280641..1280962,1281031..1281339,1281419..1281778,1281854..1282264,1282324..1282421) I 1 NT_166525.1 Similarity: the ORF is much longer than the N. crassa protein (956 compared to 354 amino acids).; Similarity: the ORF shows strong similarity to the complete sequence of the N. crassa protein.; Title: strong similarity to hypothetical protein encoded by gene B18D24.50 - Neurospora crassa; uncharacterized protein 1282421 4984097 An09g05650 Aspergillus niger uncharacterized protein XP_001393875.3 1280641 D 5061 CDS An09g05655 4984098 1282792..1284198 I 1 NT_166525.1 Title: strong similarity to SEQ ID NO:4184 from patent WO200056762-A2 - Aspergillus niger; uncharacterized protein 1284198 4984098 An09g05655 Aspergillus niger uncharacterized protein XP_001393876.1 1282792 D 5061 CDS An09g05660 4984099 complement(join(1284653..1284762,1284862..1285279,1285333..1285375,1285503..1285841,1285897..1286474,1286523..1286614,1286664..1286689,1286743..1286932,1286993..1287051,1287108..1287258,1287311..1287429,1287487..1287515)) I 1 NT_166525.1 Remark: the deletion of Qns1 in S. cerevisiae is lethal.; Title: strong similarity to NAD+ synthase Qns1 -Saccharomyces cerevisiae; uncharacterized protein 1287515 4984099 An09g05660 Aspergillus niger uncharacterized protein XP_059606960.1 1284653 R 5061 CDS An09g05670 4984100 join(1287603..1287704,1287892..1287994,1288090..1288500,1288594..1289267) I 1 NT_166525.1 Remark: yeast protein belongs to the nudix hydrolase family and is a conserved hypothetical protein in various species, i. e. S. pombe, D. radiodurans, P. aeruginosa etc.; Title: similarity to hypothetical protein YGL067w -Saccharomyces cerevisiae; uncharacterized protein 1289267 4984100 An09g05670 Aspergillus niger uncharacterized protein XP_059606961.1 1287603 D 5061 CDS An09g05680 4984101 complement(join(1289623..1293582,1293615..1294007)) I 1 NT_166525.1 Similarity: the ORF is aspartic and glutamic acid-rich and thus shows also unspecic similarity to other proteins.; Similarity: the ORF shows strong and specific N-terminal similarity to the N. crassa protein.; Title: strong similarity to hypothetical protein of gene 93G11.180 - Neurospora crassa; uncharacterized protein 1294007 4984101 An09g05680 Aspergillus niger uncharacterized protein XP_059606962.1 1289623 R 5061 CDS An09g05690 4984102 join(1294084..1294183,1294255..1294327,1294412..1294633,1294688..1296092) I 1 NT_166525.1 Alternative name: fmo1, fmo2, fmo3, fmo4, fmo5,tissuespecific nomenclature.; Catalytic activity: N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)O.; Remark: the human protein is involved in the oxidative metabolism of a variety of xenobiotics.; Title: similarity to dimethylaniline monooxygenase 4 (N-oxide forming) FMO4 - Homo sapiens; See PMID 9804831; See PMID 11042094; See PMID 1417778; uncharacterized protein 1296092 4984102 An09g05690 Aspergillus niger uncharacterized protein XP_001393880.3 1294084 D 5061 CDS An09g05700 4984103 complement(join(1296276..1296371,1296423..1296789,1296888..1297147)) I 1 NT_166525.1 Title: strong similarity to hypothetical conserved protein of gene 12F11.210 - Neurospora crassa; uncharacterized protein 1297147 4984103 An09g05700 Aspergillus niger uncharacterized protein XP_001393881.1 1296276 R 5061 CDS An09g05710 4984104 join(1298575..1298796,1298905..1300215,1300286..1301095,1301154..1302095) I 1 NT_166525.1 Remark: blast hits result from repetitive sequences and cover only part of the sequence.; Title: similarity to desmoplakin I DSP - Homo sapiens; See PMID 1689290; uncharacterized protein 1302095 4984104 An09g05710 Aspergillus niger uncharacterized protein XP_059606963.1 1298575 D 5061 CDS An09g05720 84592069 complement(join(1302265..1302311,1302358..1302517)) I 1 NT_166525.1 hypothetical protein 1302517 84592069 An09g05720 Aspergillus niger hypothetical protein XP_059606964.1 1302265 R 5061 CDS An09g05730 4984106 complement(join(1303292..1304989,1305049..1305804,1305862..1309290,1309343..1309634,1309685..1309971)) I 1 NT_166525.1 Remark: alb1 is required for conidial pigmentation in A. fumigatus and involved in dihydroxynaphthalene-melanin biosynthesis.; Remark: pigmentation is important for infection in A. fumigatus.; Title: strong similarity to polyketide synthase alb1 - Aspergillus fumigatus; See PMID 9620950; See PMID 10515939; uncharacterized protein 1309971 4984106 An09g05730 Aspergillus niger uncharacterized protein XP_059606965.1 1303292 R 5061 CDS An09g05740 84592070 join(1310152..1310240,1310287..1310408,1310446..1310683,1310776..1310871,1310998..1311075,1311155..1311250,1311331..1311393,1311479..1311515,1311607..1311732) I 1 NT_166525.1 hypothetical protein 1311732 84592070 An09g05740 Aspergillus niger hypothetical protein XP_059606966.1 1310152 D 5061 CDS An09g05750 84592071 complement(join(1311809..1311959,1312047..1312280,1312722..1313027,1313334..1313461,1313563..1313721)) I 1 NT_166525.1 hypothetical protein 1313721 84592071 An09g05750 Aspergillus niger hypothetical protein XP_059606967.1 1311809 R 5061 CDS An09g05760 4984109 join(1314204..1318081,1318238..1318370,1318454..1318510) I 1 NT_166525.1 Remark: partial similarity.; Title: similarity to hypothetical protein SPAC9G1.06c - Schizosaccharomyces pombe; uncharacterized protein 1318510 4984109 An09g05760 Aspergillus niger uncharacterized protein XP_059606968.1 1314204 D 5061 CDS An09g05770 4984110 complement(1318879..1320303) I 1 NT_166525.1 Catalytic activity: (polyphosphate)n + H2O = (polyphosphate)n-1 + orthophosphate.; Function: degradation of inorganic polyphosphates.; Remark: belongs to the PPase class C family.; Title: strong similarity to cytosolic exopolyphosphatase Ppx1 - Saccharomyces cerevisiae; cytoplasm; See PMID 7860598; uncharacterized protein 1320303 4984110 An09g05770 Aspergillus niger uncharacterized protein XP_001393888.1 1318879 R 5061 CDS An09g05780 4984111 <1320929..1321987 I 1 NT_166525.1 Catalytic activity: 1-aminocyclopropane-1-carboxylate + H(2)O = 2-oxobutanoate + NH(3).; Remark: 1-aminocyclopropane-1-carboxylic acid (ACC) is a precursor of the plant hormone ethylene.; Remark: protein is truncated due to the contig beginning.; Title: strong similarity to ACC deaminase -Penicillium citrinum [truncated ORF]; See PMID 10737185; uncharacterized protein 1321987 4984111 An09g05780 Aspergillus niger uncharacterized protein XP_059601442.1 1320929 D 5061 CDS An09g05790 84592072 complement(1322614..1323291) I 1 NT_166525.1 Remark: homology is restricted to C-terminal BAG domains.; Title: weak similarity to BAG-family molecular chaperone regulator-4 - Homo sapiens; uncharacterized protein 1323291 84592072 An09g05790 Aspergillus niger uncharacterized protein XP_059601443.1 1322614 R 5061 CDS An09g05800 4984113 complement(join(1323791..1326470,1326659..1327460,1327530..1327578,1327674..1328063)) I 1 NT_166525.1 Function: protein acts specifically as a repressor for genes regulated by the b mating type locus in Ustilago maydis.; Title: strong similarity to transcription regulator rum1 - Ustilago maydis; nucleus; See PMID 11029697; uncharacterized protein 1328063 4984113 An09g05800 Aspergillus niger uncharacterized protein XP_059601444.1 1323791 R 5061 CDS An09g05810 84592073 join(1328079..1328225,1328297..1328404,1328504..1328584,1328709..1328774) I 1 NT_166525.1 hypothetical protein 1328774 84592073 An09g05810 Aspergillus niger hypothetical protein XP_059601445.1 1328079 D 5061 CDS An09g05820 84592074 join(1330211..1330276,1330629..1330947,1331215..1331321,1331407..1331454) I 1 NT_166525.1 hypothetical protein 1331454 84592074 An09g05820 Aspergillus niger hypothetical protein XP_059601446.1 1330211 D 5061 CDS An09g05830 4984116 join(1331633..1331880,1331942..1332968) I 1 NT_166525.1 Title: strong similarity to hypothetical protein 8D4.30 - Neurospora crassa; uncharacterized protein 1332968 4984116 An09g05830 Aspergillus niger uncharacterized protein XP_059601447.1 1331633 D 5061 CDS An09g05840 4984117 complement(join(1333018..1333547,1333610..1333754)) I 1 NT_166525.1 Catalytic activity: ATP + thymidine 5'-phosphate <=> ADP + thymidine 5'-diphosphate.; Title: strong similarity to thymidylate kinase CDC8 - Homo sapiens; uncharacterized protein 1333754 4984117 An09g05840 Aspergillus niger uncharacterized protein XP_001393895.1 1333018 R 5061 CDS An09g05850 4984118 join(1334358..1334547,1334629..1335707) I 1 NT_166525.1 Catalytic activity: tRNA guanine + queuine = tRNA queuine + guanine.; Remark: important for virulence in Shigella flexneri.; Remark: similarity only with the C-terminus of the proteins.; Title: similarity to queuine tRNA-ribosyltransferase - Shigella flexneri; See PMID 8045893; uncharacterized protein 1335707 4984118 An09g05850 Aspergillus niger uncharacterized protein XP_001393896.3 1334358 D 5061 CDS An09g05860 4984119 complement(join(1336410..1338422,1338513..1338599)) I 1 NT_166525.1 Catalytic activity: 5-methyltetrahydrofolate + NADP+ = 5,10-methylenetetrahydrofolate + NADPH.; Title: strong similarity to methylenetetrahydrofolate reductase (NADPH) Met12 -Saccharomyces cerevisiae; See PMID 10600168; uncharacterized protein 1338599 4984119 An09g05860 Aspergillus niger uncharacterized protein XP_001393897.3 1336410 R 5061 CDS An09g05870 4984120 complement(join(1340195..1340329,1340382..1340446,1340501..1340566,1340627..1340730,1340787..1340830,1340920..1340950,1341122..1341138)) I 1 NT_166525.1 Catalytic activity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.; Title: strong similarity to nucleoside-diphosphate kinase NDK-1 - Neurospora crassa; cytoplasm; See PMID 10583364; uncharacterized protein 1341138 4984120 An09g05870 Aspergillus niger uncharacterized protein XP_001393898.1 1340195 R 5061 CDS An09g05880 4984121 join(1341711..1341777,1341842..1342583,1342638..1344702) I 1 NT_166525.1 Catalytic activity: hydrolysis of terminal,non-reducing 1,4-linked alpha-D-glucose residues with release of alpha-D-glucose.; Title: strong similarity to alpha-glucosidase ModA -Dictyostelium discoideum; See PMID 96112; See PMID 96113; uncharacterized protein 1344702 4984121 An09g05880 Aspergillus niger uncharacterized protein XP_001393899.1 1341711 D 5061 CDS An09g05890 4984122 join(1345532..1345554,1345617..1345832,1345908..1346328) I 1 NT_166525.1 Title: similarity to hypothetical membrane protein YMR010w - Saccharomyces cerevisiae; uncharacterized protein 1346328 4984122 An09g05890 Aspergillus niger uncharacterized protein XP_001393900.3 1345532 D 5061 CDS An09g05900 4984123 join(1346761..1346803,1346938..1347280,1347343..1347940) I 1 NT_166525.1 Remark: the ORF has an unusual exon/intron structure for A. niger.; Title: similarity to hypothetical protein EAA58873.1 - Aspergillus nidulans; uncharacterized protein 1347940 4984123 An09g05900 Aspergillus niger uncharacterized protein XP_001393901.1 1346761 D 5061 CDS An09g05910 84592075 complement(join(1348057..1348103,1348177..1348392,1348809..1348954,1349317..1349399)) I 1 NT_166525.1 hypothetical protein 1349399 84592075 An09g05910 Aspergillus niger hypothetical protein XP_059601448.1 1348057 R 5061 CDS An09g05920 4984125 join(1349498..1349606,1349679..1349723,1349776..1349789,1349849..1349976,1350030..1350798) I 1 NT_166525.1 Function: chit33 of T. harzianum random hydrolysis N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins.; Title: strong similarity to chitinase precursor chit33 - Trichoderma harzianum; See PMID 8575023; uncharacterized protein 1350798 4984125 An09g05920 Aspergillus niger uncharacterized protein XP_059601449.1 1349498 D 5061 CDS An09g05930 84592076 complement(<1351486..1351635) I 1 NT_166525.1 Remark: C-terminally truncated ORF due to contig border.; hypothetical protein [truncated ORF] 1351635 84592076 An09g05930 Aspergillus niger hypothetical protein [truncated ORF] XP_059601450.1 1351486 R 5061 CDS An09g05940 4984127 join(1351717..1351942,1352010..1352813,1352922..1353070) I 1 NT_166525.1 Function: the purified enzyme catalyzes the conversion of reduced glutathione to its disulfide form,with concomitant consumption of O2 and release of H2O2.; Gene-ID: Sox; See PMID 10542195; See PMID 3427078; sulphydryl oxidase Sox from patent EP565172-A1-Aspergillus niger 1353070 Sox 4984127 Sox Aspergillus niger sulphydryl oxidase Sox from patent EP565172-A1-Aspergillus niger XP_001393905.1 1351717 D 5061 CDS An09g05950 4984128 complement(join(1354325..1356031,1356087..1356761,1356839..1357062,1357128..1357581)) I 1 NT_166525.1 Title: strong similarity to plasma membrane ATPase PMA1 - Kluyveromyces lactis; plasma membrane; See PMID 7730265; uncharacterized protein 1357581 4984128 An09g05950 Aspergillus niger uncharacterized protein XP_001393906.1 1354325 R 5061 CDS An09g05960 84592077 complement(join(1357996..1358216,1358264..1358485,1358630..1358642)) I 1 NT_166525.1 hypothetical protein 1358642 84592077 An09g05960 Aspergillus niger hypothetical protein XP_059601451.1 1357996 R 5061 CDS An09g05965 84592078 1358868..1359107 I 1 NT_166525.1 hypothetical protein 1359107 84592078 An09g05965 Aspergillus niger hypothetical protein XP_059601452.1 1358868 D 5061 CDS An09g05970 4984131 complement(join(1359539..1361413,1361471..1361734)) I 1 NT_166525.1 Remark: the predicted ORF shows similarity to several cytosolic glutamate--tRNA ligases from different species.; Title: strong similarity to cytosolic glutamate--tRNA ligase - Arabidopsis thaliana; cytoplasm; uncharacterized protein 1361734 4984131 An09g05970 Aspergillus niger uncharacterized protein XP_001393909.1 1359539 R 5061 CDS An09g05980 4984132 join(1361845..1362197,1362262..1362826,1362884..1362976) I 1 NT_166525.1 Title: similarity to ribosomal protein of the large subunit L1 rplA - Escherichia coli; See PMID 381841; mitochondrial 54S ribosomal protein uL1m 1362976 4984132 An09g05980 Aspergillus niger mitochondrial 54S ribosomal protein uL1m XP_001393910.3 1361845 D 5061 CDS An09g05990 4984133 complement(join(1363140..1364015,1364175..1364414,1364494..1364733)) I 1 NT_166525.1 Title: similarity to hypothetical protein CAD71232.1 - Neurospora crassa; uncharacterized protein 1364733 4984133 An09g05990 Aspergillus niger uncharacterized protein XP_059601453.1 1363140 R 5061 CDS An09g06000 4984134 1364769..1365998 I 1 NT_166525.1 Remark: blast hits are caused by repetitive sequence-motives.; Title: weak similarity to hypothetical membrane protein YJR151c - Saccharomyces cerevisiae; uncharacterized protein 1365998 4984134 An09g06000 Aspergillus niger uncharacterized protein XP_001393912.1 1364769 D 5061 CDS An09g06010 4984135 complement(join(1366276..1366970,1367070..1367238,1367448..1367480)) I 1 NT_166525.1 Similarity: YIL003w of S. cerevisiae belongs to the mrp/nbp35 family of ATP-binding proteins.; Title: strong similarity to hypothetical membrane protein YIL003w - Saccharomyces cerevisiae; uncharacterized protein 1367480 4984135 An09g06010 Aspergillus niger uncharacterized protein XP_059601454.1 1366276 R 5061 CDS An09g06020 4984136 complement(join(1367956..1368670,1368720..1369099,1369157..1369228)) I 1 NT_166525.1 Function: S. cerevisiae mutations in SHP1 markedly reduce catalytic activity of the phosphoprotein phosphatase 1 (PP1) catalytic subunit Glc7 without noticeably affecting the level or distribution of the protein.; Function: S. cerevisiae mutations in SHP1 totally block sporulation and slightly slow cell proliferation and show deficient glycogen accumulation.; Function: the S. cerevisiae SHP1 is involved in the glycogen metabolism.; Function: the human homologe of yeast SHP1, p47 binds to the ATPase p97 which is involved in the heterotypic fusion of transport vesicles with their target membranes and the homotypic fusion of membrane compartments.; Remark: the systematic name for SHP1 of S. cerevisiae is YBL058w.; Title: strong similarity to regulator of phosphoprotein phosphatase 1 Shp1 - Saccharomyces cerevisiae; cytoplasm; See PMID 9214505; See PMID 7891699; uncharacterized protein 1369228 4984136 An09g06020 Aspergillus niger uncharacterized protein XP_001393914.1 1367956 R 5061 CDS An09g06030 4984137 join(1370864..1371790,1371845..1372474) I 1 NT_166525.1 Complex: S. cerevisiae Oxa1p is a constituent of an oligomeric complex.; Function: S. cerevisiae Oxa1p appears to be involved in the insertion of pairs of transmembrane segments into the inner membrane leading to the export of hydrophilic segments between them.; Function: S. cerevisiae Oxa1p mediates the export of mitochindrial encoded genes like Cytochrome oxidase II from the matrix.; Function: S. cerevisiae Oxa1p mediates the membrane potential-dependent export of N-terminal tails of nuclear encoded proteins from the matrix to the intermembrane space in order to locate the N termini in the intermembrane space.; Function: S. cerevisiae Oxa1p represents a component of a novel, general export machinery in the mitochondrial inner membrane.; Localization: S. cerevisiae Oxa1p spans the inner membrane of the mitochondrion five times and has an N out C in orientation.; Title: strong similarity to mitochondrial intermembrane space.export machinery component Oxa1 -Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9482871; uncharacterized protein 1372474 4984137 An09g06030 Aspergillus niger uncharacterized protein XP_059601455.1 1370864 D 5061 CDS An09g06040 4984138 complement(join(1377830..1378373,1378445..1378935)) I 1 NT_166525.1 Complex: TFIID is a multisubunit complex consisting of the TATA-binding protein (TBP) and several TBP-associated factors (TAFs).; Function: TFIID recognizes the core promoter and supplies a scaffolding upon which the rest of the transcriptional machinery can assemble.; Function: the basal transcription factor TFIID coordinates the combined activities of more than 70 polypeptides required for synthesis of mRNA by RNA polII.; Similarity: the predicted ORF is N- and C-terminally extented compared to putative homologues of other species.; Title: similarity to subunit of transcription initiation factor TFIID TAFII28 - Homo sapiens; nucleus; See PMID 10721692; See PMID 8820923; uncharacterized protein 1378935 4984138 An09g06040 Aspergillus niger uncharacterized protein XP_001393916.1 1377830 R 5061 CDS An09g06050 4984139 complement(join(1379565..1380943,1381000..1381120)) I 1 NT_166525.1 Catalytic activity: S-adenosylmethionine decarboxylases catalyse the reaction,S-adenosyl-L-methionine <=> (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt + CO(2).; Function: N. crassa Spe-2 catalyzes the formation of decarboxylated AdoMetDC, a precursor of the polyamines spermidine and spermine.; Remark: S-adenosylmethionine decarboxylases is a potentially important drug target for the chemotherapy of cancer and parasitic diseases.; Title: strong similarity to S-adenosylmethionine decarboxylase spe-2 - Neurospora crassa; cytoplasm; See PMID 10852489; See PMID 1764068; uncharacterized protein 1381120 4984139 An09g06050 Aspergillus niger uncharacterized protein XP_001393917.1 1379565 R 5061 CDS An09g06060 84592079 complement(join(1381220..1381341,1381427..1381487,1381609..>1381851)) I 1 NT_166525.1 Catalytic activity: phospholipases from the A1 type catalyse the reaction, Phosphatidylcholine + H(2)O <=> 2-acylglycerophosphocholine + a fatty acid anion.; Remark: ORF 5' truncated due to end of Contig.; Title: weak similarity to phospholipase A1 -Polistes annularis [truncated ORF]; See PMID 6712224; uncharacterized protein 1381851 84592079 An09g06060 Aspergillus niger uncharacterized protein XP_059601456.1 1381220 R 5061 CDS An09g06070 4984141 complement(join(1382352..1382408,1382496..1382521,1382634..1383111,1383168..1383586,1383654..1384023)) I 1 NT_166525.1 Complex: binds tightly to TAFII-250 and also directly interacts with TAFII-40.; Function: the X. laevis transcription factor IID 60 KD subunit p80 plays a central role in mediating promotor responses to various activators and repressors.; Similarity: belongs to the TAF2E family.; Title: strong similarity to subunit of transcription initiation factor TFIID p80 - Xenopus laevis; nucleus; See PMID 7590360; uncharacterized protein 1384023 4984141 An09g06070 Aspergillus niger uncharacterized protein XP_001393919.3 1382352 R 5061 CDS An09g06080 84592080 complement(join(1385109..1385214,1385297..1385414,1385547..1385647,1385784..1385875,1385984..1386073,1386163..1386222)) I 1 NT_166525.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1386222 84592080 An09g06080 Aspergillus niger uncharacterized protein XP_059606701.1 1385109 R 5061 CDS An09g06090 84592081 join(1386515..1386619,1386688..1386706,1386762..1386914,1387034..1387199,1387247..1387336,1387381..1387414,1387475..1387692,1387739..1387799,1387846..1387854) I 1 NT_166525.1 Function: the Streptomyces sp. pentalenene synthase catalyzes the cyclization of farnesyl diphosphat to the tricyclic sesquiterpene hydrocarbon pentalenene.; Pathway: the enzyme pentalenene synthase is involved in the biosynthesis of pentalenolactone and related antibiotics.; Title: strong similarity to pentalenene synthase -Streptomyces sp.; See PMID 8180213; uncharacterized protein 1387854 84592081 An09g06090 Aspergillus niger uncharacterized protein XP_059606702.1 1386515 D 5061 CDS An09g06100 4984144 join(1388378..1388669,1388717..1388783,1388842..1388950,1389006..1389092,1389280..1389874,1389948..1389964) I 1 NT_166525.1 Phenotype: disruption of the A. thaliana AtSPO11-1 protein results in altered meiotic progression, few bivalents, no fully synapsed chromosomes during prophase I and chromosomes segregated randomly in meiosis I.; Remark: a putative sequencing error results in an premature STOP-codon.; Remark: the SPO11 protein from S. cerevisiae catalyses DNA double-strand breaks (DSBs) that initiate meiotic recombination.; Title: similarity to hypothetical double strand break catalysing AtSPO11-1 - Arabidopsis thaliana [putative sequencing error]; putative sequencing error; See PMID 11157765; uncharacterized protein 1389964 4984144 An09g06100 Aspergillus niger uncharacterized protein XP_059606703.1 1388378 D 5061 CDS An09g06110 4984145 complement(join(1390211..1390464,1390581..1390827)) I 1 NT_166525.1 Complex: the S. pombe UbcP4 interacts with chk1 during the G2/M-phase transition and with cut9 during the metaphase/anaphase transition.; Function: the S. pombe UbcP4 protein is necessary for cell cycle progression at two phases, the G2/M and metaphase/anaphase transition.; Title: strong similarity to ubiquitin conjugating enzyme ubcp3p - Schizosaccharomyces pombe; See PMID 9154838; uncharacterized protein 1390827 4984145 An09g06110 Aspergillus niger uncharacterized protein XP_001393923.1 1390211 R 5061 CDS An09g06120 4984146 complement(join(1391652..1392613,1392787..1393315)) I 1 NT_166525.1 Function: the M. musculus Phospholipid (PL) scramblase is a 35 kDa protein that is thought to mediate Ca2+-induced bidirectional transbilayer movement of plasma membrane phospholipids in activated, injured, or apoptotic cells.; Title: similarity to cDNA phospholipid scramblase 1 - Mus musculus; See PMID 10930526; uncharacterized protein 1393315 4984146 An09g06120 Aspergillus niger uncharacterized protein XP_059606704.1 1391652 R 5061 CDS An09g06130 4984147 complement(join(1394383..1394576,1394629..1394812)) I 1 NT_166525.1 Title: similarity to hypothetical protein CAD21257.1 - Neurospora crassa; uncharacterized protein 1394812 4984147 An09g06130 Aspergillus niger uncharacterized protein XP_001393925.1 1394383 R 5061 CDS An09g06140 4984148 1395064..1395915 I 1 NT_166525.1 Remark: L2 of S. cerevisiae is also called YmL2,YMR6, MRPL2, MRP7, YNL005C, or N2007.; Remark: L2 of S. cerevisiae is essential for ribosomal function.; Similarity: the ORF is shorter than L2 of S. cerevisiae (283 compared to 371 amino acids) and the homology between the two proteins spans only a stretch of about 130 amino acids.; Title: strong similarity to mitochondrial ribosomal protein of the large subunit L2 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 2851722; mitochondrial 54S ribosomal protein bL27m 1395915 4984148 An09g06140 Aspergillus niger mitochondrial 54S ribosomal protein bL27m XP_001393926.1 1395064 D 5061 CDS An09g06150 4984149 complement(join(1396257..1400552,1400642..1400686)) I 1 NT_166525.1 Function: epistasis analysis with other S. pombe checkpoint mutants indicates that rhp9 acts in a process involving the checkpoint rad genes and that the rhp9 mutant is phenotypically very similar to chk1.; Function: the S. pombe rhp9 protein (S. cerevisiae Rad9 homologue, also known as Crb2) is required for the DNA damage checkpoint, but not the replication checkpoint.; Similarity: similarity is from the C-terminal region of the predicted A. niger protein (aa952 - aa1349) to the C-terminal part of the S. pombe protein.; Title: similarity to DNA damage checkpoint protein rhp9p - Schizosaccharomyces pombe; See PMID 10488332; See PMID 9153313; uncharacterized protein 1400686 4984149 An09g06150 Aspergillus niger uncharacterized protein XP_059606705.1 1396257 R 5061 CDS An09g06160 4984150 complement(1401168..1402646) I 1 NT_166525.1 Complex: the S. cerevisiae SEN2 forms a tetrameric enzyme with two active sites.; Function: SEN2 catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron.; Function: the S. cerevisiae SEN2 splices the tRNA precursors which is essential for the production of mature tRNA.; Remark: SEN2 of S. cerevisiae is also known as YLR105C.; Remark: the systematic name of SEN2 is YLR105C.; Title: strong similarity to tRNA splicing endonuclease beta-subunit Sen2 - Saccharomyces cerevisiae; See PMID 9200603; uncharacterized protein 1402646 4984150 An09g06160 Aspergillus niger uncharacterized protein XP_001393928.1 1401168 R 5061 CDS An09g06170 4984151 join(1403450..1403462,1403521..1403635,1403708..1403760,1403819..1403841) I 1 NT_166525.1 Similarity: the ORF has also a match against an A. niger EST SEQ ID NO:3997 from patent WO200056762-A2.; Title: strong similarity to hypothetical protein YHR072w-a - Saccharomyces cerevisiae; uncharacterized protein 1403841 4984151 An09g06170 Aspergillus niger uncharacterized protein XP_001393929.1 1403450 D 5061 CDS An09g06180 4984152 complement(join(1404168..1404680,1404734..1405002,1405075..1405522)) I 1 NT_166525.1 Function: HP-10 is considered to be a new regulatory phosphorylation protein because it has no intrinsic kinase activity.; Function: bacteria expressing the HP-10 encoded protein were found to have a dramatic increase in endogenous phosphorylated proteins.; Title: similarity to phosphorylation regulatory protein HP-10 - Homo sapiens; See PMID 1791827; uncharacterized protein 1405522 4984152 An09g06180 Aspergillus niger uncharacterized protein XP_059606706.1 1404168 R 5061 CDS An09g06190 84592082 complement(join(1405716..1405841,1405925..1405990,1406169..1406319,1406807..1406911,1407038..1407205,1407436..1407540,1407684..1407795,1407891..1408064,1408217..1408398,1408488..1408522)) I 1 NT_166525.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1408522 84592082 An09g06190 Aspergillus niger uncharacterized protein XP_059606707.1 1405716 R 5061 CDS An09g06200 4984154 join(1409021..1409218,1409278..1409382,1409444..1409817,1409877..1409944,1409999..1410417) I 1 NT_166525.1 Localization: PTH11 of M. grisea was localized as a GFP-fusion protein in the cell membrane and in the vacuoles.; Phenotype: pth11 mutants of strain 4091-5-8 are nonpathogenic due to a defect in appressorium differentiation. This suggests that Pth11p functions at the cell cortex as an upstream effector of appressorium differentiation.; Title: strong similarity to transmembrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529; uncharacterized protein 1410417 4984154 An09g06200 Aspergillus niger uncharacterized protein XP_001393932.3 1409021 D 5061 CDS An09g06210 4984155 join(1411529..1411680,1411732..1412530,1412579..1412740,1412785..1413254,1413324..1413729) I 1 NT_166525.1 Pathway: the lovastatin biosynthesis is part of the polyketide metabolism. Two type I polyketide synthase genes are required: LNKS and LovC.; Remark: the fungal metabolite lovastatin and its derivatives are widely prescribed cholesterol-lowering drugs that act as potent inhibitors of (3S)-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMG-CoA reductase).; Similarity: the N-terminal region of the predicted A. niger protein contains a fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain.; Title: strong similarity to hypothetical regulator protein of the lovastatin biosynthesis - Aspergillus terreus; See PMID 10334994; uncharacterized protein 1413729 4984155 An09g06210 Aspergillus niger uncharacterized protein XP_001393933.1 1411529 D 5061 CDS An09g06220 4984156 complement(join(1413958..1415190,1415288..1415680)) I 1 NT_166525.1 Pathway: the lovastatin biosynthesis is part of the polyketide metabolism. Two type I polyketide synthase genes are required: LNKS and LovC.; Remark: the fungal metabolite lovastatin and its derivatives are widely prescribed cholesterol-lowering drugs that act as potent inhibitors of (3S)-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMG-CoA reductase).; Similarity: the N-terminal region of the predicted A. niger protein contains a Prokaryotic membrane lipoprotein lipid attachment site.; Title: strong similarity to hypothetical protein of the lovastatin biosynthesis gene cluster - Aspergillus terreus; uncharacterized protein 1415680 4984156 An09g06220 Aspergillus niger uncharacterized protein XP_001393934.1 1413958 R 5061 CDS An09g06230 4984157 complement(join(1416689..1417393,1417466..1417609)) I 1 NT_166525.1 Similarity: this gene shows also similarity to the hypothetical protein encoded by An13g01740 Aspergillus niger.; Title: similarity to hypothetical protein 25D9-9 -Aspergillus fumigatus; uncharacterized protein 1417609 4984157 An09g06230 Aspergillus niger uncharacterized protein XP_001393935.1 1416689 R 5061 CDS An09g06240 4984158 join(1418770..1418823,1418938..1419319,1419397..>1419554) I 1 NT_166525.1 Title: similarity to hypothetical protein encoded by An09g06370 - Aspergillus niger; uncharacterized protein 1419554 4984158 An09g06240 Aspergillus niger uncharacterized protein XP_059606708.1 1418770 D 5061 CDS An09g06250 4984159 complement(1420067..1421617) I 1 NT_166525.1 Function: the S. cerevisiae homolog aminopeptidase I is a vacuolar enzyme, which catalyzes the removal of amino acids from the NH2 terminus of peptides and proteins.; Title: strong similarity to vacuolar aminopeptidase Ysci - Saccharomyces cerevisiae; vacuole; See PMID 2651436; See PMID 7750534; uncharacterized protein 1421617 4984159 An09g06250 Aspergillus niger uncharacterized protein XP_001393937.1 1420067 R 5061 CDS An09g06260 4984160 complement(join(1422078..1422653,1422701..1423342,1423434..1423478)) I 1 NT_166525.1 Title: similarity to mutanase mutA - Aspergillus oryzae; See PMID 10636904; uncharacterized protein 1423478 4984160 An09g06260 Aspergillus niger uncharacterized protein XP_059601457.1 1422078 R 5061 CDS An09g06265 84592083 complement(1424134..1424382) I 1 NT_166525.1 hypothetical protein 1424382 84592083 An09g06265 Aspergillus niger hypothetical protein XP_059601458.1 1424134 R 5061 CDS An09g06270 4984162 join(1424941..1425103,1425166..1425261,1425335..1425547,1425632..1426209,1426277..1426555) I 1 NT_166525.1 Title: strong similarity to hypothetical glutathione-dependent formaldehyde dehydrogenase SPBC1198.01 - Schizosaccharomyces pombe; uncharacterized protein 1426555 4984162 An09g06270 Aspergillus niger uncharacterized protein XP_059601459.1 1424941 D 5061 CDS An09g06275 84592084 complement(1427500..1427790) I 1 NT_166525.1 hypothetical protein 1427790 84592084 An09g06275 Aspergillus niger hypothetical protein XP_059601460.1 1427500 R 5061 CDS An09g06280 4984164 1428557..1430044 I 1 NT_166525.1 Title: strong similarity to hypothetical transcription factor BAB47239.1 - Aspergillus oryzae; uncharacterized protein 1430044 4984164 An09g06280 Aspergillus niger uncharacterized protein XP_003188786.1 1428557 D 5061 CDS An09g06290 4984165 complement(join(1430983..1432107,1432180..1432563)) I 1 NT_166525.1 Title: similarity to hypothetical protein SPAC1B2.02c - Schizosaccharomyces pombe; uncharacterized protein 1432563 4984165 An09g06290 Aspergillus niger uncharacterized protein XP_001393943.1 1430983 R 5061 CDS An09g06300 4984166 join(1432947..1433206,1433264..1433370,1433446..1433690) I 1 NT_166525.1 Remark: the adrenodoxin precursor protein of Sus scrofa transfers electrons to cytochromes P450 of the vitamin D pathway.; Title: similarity to hypothetical adrenodoxin precursor protein - Sus scrofa; localisation:mitochondrion; uncharacterized protein 1433690 4984166 An09g06300 Aspergillus niger uncharacterized protein XP_001393944.1 1432947 D 5061 CDS An09g06310 4984167 complement(1434010..1434888) I 1 NT_166525.1 Title: similarity to hypothetical protein YPR143w -Saccharomyces cerevisiae; uncharacterized protein 1434888 4984167 An09g06310 Aspergillus niger uncharacterized protein XP_001393945.1 1434010 R 5061 CDS An09g06320 4984168 join(1435261..1435338,1435388..1436914) I 1 NT_166525.1 Function: This protein is one component involved in the translocation of a nascent polypeptide from the cytoplasm into the endoplasmic reticulum.; Gene-ID: srpA; cytoplasm; See PMID 8566805; signal recognition particle 54K protein homolog srpA-Aspergillus niger 1436914 srpA 4984168 srpA Aspergillus niger signal recognition particle 54K protein homolog srpA-Aspergillus niger XP_059601461.1 1435261 D 5061 CDS An09g06330 4984169 complement(join(1437068..1437100,1437148..1437187,1437340..1437390,1437620..1439318,1439383..1439521,1439580..1439657)) I 1 NT_166525.1 Title: similarity to protein fragment SEQ ID NO:5981 from patent EP1108790-A2 - Corynebacterium glutamicum; uncharacterized protein 1439657 4984169 An09g06330 Aspergillus niger uncharacterized protein XP_059601462.1 1437068 R 5061 CDS An09g06340 84592085 complement(1439985..1440854) I 1 NT_166525.1 Title: strong similarity to immunogenic protein #11392 from patent WO200181581-A2 - Propionibacterium acnes; uncharacterized protein 1440854 84592085 An09g06340 Aspergillus niger uncharacterized protein XP_059601463.1 1439985 R 5061 CDS An09g06350 4984171 join(1442470..1443070,1443113..1444650) I 1 NT_166525.1 Function: the snaD gene of Aspergillus nidulans suppresses mutations in the cytoplasmatic dynein heavy chain gene nudA1, which inhibit nuclear migration, colony growth and asexual sporulation (conidiation).; Title: strong similarity to protein snaD -Aspergillus nidulans; See PMID 10821171; uncharacterized protein 1444650 4984171 An09g06350 Aspergillus niger uncharacterized protein XP_059601464.1 1442470 D 5061 CDS An09g06360 4984172 complement(join(1445176..1446580,1446629..1446906,1446959..1446991)) I 1 NT_166525.1 Remark: similarities correspond to multiple serine repeats.; hypothetical protein 1446991 4984172 An09g06360 Aspergillus niger hypothetical protein XP_059601465.1 1445176 R 5061 CDS An09g06370 4984173 1450236..1451051 I 1 NT_166525.1 Similarity: the ORF encoded protein shows also weak similarity to hypothetical protein 3 from Rhizobium leguminosarum.; Title: similarity to hypothetical protein encoded by An15g02610 - Aspergillus niger; uncharacterized protein 1451051 4984173 An09g06370 Aspergillus niger uncharacterized protein XP_001393951.1 1450236 D 5061 CDS An09g06380 4984174 complement(join(1451290..1451356,1451465..1451622,1451697..1451858)) I 1 NT_166525.1 Title: strong similarity to hypothetical protein brt1 - Schizophyllum commune; uncharacterized protein 1451858 4984174 An09g06380 Aspergillus niger uncharacterized protein XP_001393952.1 1451290 R 5061 CDS An09g06390 4984175 join(1452499..1452905,1452981..1453593) I 1 NT_166525.1 Title: strong similarity to lipase LipP -Pseudomonas sp.; uncharacterized protein 1453593 4984175 An09g06390 Aspergillus niger uncharacterized protein XP_001393953.1 1452499 D 5061 CDS An09g06400 4984176 join(1456202..1456303,1456365..1456803,1456864..1460096) I 1 NT_166525.1 Catalytic activity: Random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins.; Remark: disruption of Aspergillus nidulans chiA gene substantially decreased germination frequency and hyphal growth rate.; Title: strong similarity to chitinase chiA -Aspergillus nidulans; See PMID 9501518; uncharacterized protein 1460096 4984176 An09g06400 Aspergillus niger uncharacterized protein XP_059601466.1 1456202 D 5061 CDS An09g06410 4984177 join(1461505..1461994,1462059..1462144,1462218..1462412) I 1 NT_166525.1 Remark: similarities correspond partially to multiple glutamine, glycine and serine repeats.; Title: similarity to hypothetical protein EAA66742.1 - Aspergillus nidulans; uncharacterized protein 1462412 4984177 An09g06410 Aspergillus niger uncharacterized protein XP_059601467.1 1461505 D 5061 CDS An09g06420 4984178 join(1463212..1463266,1463346..1464430) I 1 NT_166525.1 Function: cephalosporin C is a beta-lactam antibiotic.; Similarity: importantly, the ORF shows additionally strong similarity to nuclease O nucO of A. oryzae and to alpha-methylacyl-CoA racemases, but non of the sequences show significant similarity to the cephalosporin C biosynthesis protein.; Title: strong similarity to protein involved in cephalosporin C biosynthesis from patent JP06038763-A -Acremonium chrysogenum; See PMID 10592528; See PMID 1369089; uncharacterized protein 1464430 4984178 An09g06420 Aspergillus niger uncharacterized protein XP_001393956.1 1463212 D 5061 CDS An09g06425 84592086 join(1466077..1466100,1466251..1466649) I 1 NT_166525.1 hypothetical protein 1466649 84592086 An09g06425 Aspergillus niger hypothetical protein XP_059601468.1 1466077 D 5061 CDS An09g06430 4984180 1467380..1468468 I 1 NT_166525.1 Title: strong similarity to hypothetical protein AAH28592.1 - Homo sapiens; uncharacterized protein 1468468 4984180 An09g06430 Aspergillus niger uncharacterized protein XP_001393958.3 1467380 D 5061 CDS An09g06440 4984181 join(1469738..1470487,1470546..1470852,1470888..1471705) I 1 NT_166525.1 Complex: yeast CAC1, CAC2 and CAC3 form the chromatin assembly factor-I (CAF-I).; Function: RLF2 (Rap1p localization factor-2) is required for the normal distribution of the telomere-binding Rap1p protein within the nucleus. Rlf2p facilitates the efficient and timely assembly of histones into telomeric chromatin.; Phenotype: in rlf2 mutants, telomeric chromatin is perturbed, telomeric silencing is reduced and Rap1p localization is altered. in cells lacking CAF-I, the silent mating loci are derepressed partially.; Remark: deletion of any CAC gene causes an increase in sensitivity to ultraviolet radiation, without significantly increasing sensitivity to gamma rays. deletion of CAC genes also strongly reduces silencing of genes adjacent to telomeric DNA.; Similarity: the predicted A. niger protein shows strong similarity to subunit p90 of chromatin assembly factor-I (RLF2) of S. cerevisiae and similarity to several proteins described as (putative) chromatin assembly factor subunits. the A. niger protein sequence is rich in glutamic acid and lysine. the systematic name of yeast RLF2 is YPR018w. RLF2 is also known as CAC1.; Title: strong similarity to chromatin assembly factor-I (CAF-I) p90 subunit Rlf2 - Saccharomyces cerevisiae; nucleus; See PMID 9030687; See PMID 9030688; See PMID 9436982; uncharacterized protein 1471705 4984181 An09g06440 Aspergillus niger uncharacterized protein XP_059601469.1 1469738 D 5061 CDS An09g06450 4984182 join(<1475679..1476899,1476956..1477065,1477136..1480298) I 1 NT_166525.1 Remark: the ORF is truncated due to border of contig.; Title: strong similarity to hypothetical protein CAD71235.1 - Neurospora crassa [truncated ORF]; uncharacterized protein 1480298 4984182 An09g06450 Aspergillus niger uncharacterized protein XP_001393960.3 1475679 D 5061 CDS An09g06460 4984183 join(1481791..1481830,1481889..1482609,1482689..1482809) I 1 NT_166525.1 Remark: the predicted A. niger gene is identical to the A. niger patent EST WO200056762-A2 from bp 511 to bp 882.; Title: strong similarity to hypothetical Glc8 related protein CAD21258.1 - Neurospora crassa; uncharacterized protein 1482809 4984183 An09g06460 Aspergillus niger uncharacterized protein XP_001393961.1 1481791 D 5061 CDS An09g06470 84592087 join(1483452..1483466,1483596..1483663,1483706..1483727,1483774..1483848,1483885..1483897,1483938..1483956,1483988..1484039) I 1 NT_166525.1 Remark: ORF classified questionable due to length below 100 aa and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1484039 84592087 An09g06470 Aspergillus niger uncharacterized protein XP_059601470.1 1483452 D 5061 CDS An09g06480 4984185 join(1484544..1485307,1485371..1486040) I 1 NT_166525.1 Title: similarity to hypothetical protein YJL145w -Saccharomyces cerevisiae; uncharacterized protein 1486040 4984185 An09g06480 Aspergillus niger uncharacterized protein XP_001393963.1 1484544 D 5061 CDS An09g06490 4984186 join(1486670..1487340,1487401..1488846,1488896..1488986) I 1 NT_166525.1 Title: strong similarity to oxide squalene cyclising enzyme from patent JP08308568-A - Rattus rattus; See PMID 8604986; uncharacterized protein 1488986 4984186 An09g06490 Aspergillus niger uncharacterized protein XP_001393964.1 1486670 D 5061 CDS An09g06500 4984187 join(1489399..1490196,1490252..1490834,1490868..1490914) I 1 NT_166525.1 Complex: Sgt1p physically associates with Skp1p in vivo and in vitro, and thus also associates with SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase.; Function: the S. cerevisiae Sgt1p is required for assembling the yeast kinetochore complex, CBF3, via activation of Ctf13p.; Remark: human SGT1 rescues an sgt1 null mutation in S. cervisiae, suggesting that the function of SGT1 is conserved in evolution.; Title: strong similarity to protein Sgt1 -Saccharomyces cerevisiae; See PMID 10445024; uncharacterized protein 1490914 4984187 An09g06500 Aspergillus niger uncharacterized protein XP_001393965.3 1489399 D 5061 CDS An09g06510 4984188 complement(join(1491409..1491917,1492128..1492510,1492568..1492623)) I 1 NT_166525.1 Remark: the H. sapiens patent transmembrane protein WO200056891-A2 is involved in various human disorders.; Title: strong similarity to human transmembrane from patent WO200056891-A2 - Homo sapiens; uncharacterized protein 1492623 4984188 An09g06510 Aspergillus niger uncharacterized protein XP_059601471.1 1491409 R 5061 CDS An09g06520 4984189 join(1493127..1493857,1493939..1494281) I 1 NT_166525.1 Remark: the H. sapiens SIRT4 belongs to a group of four human SIRT proteins (SIRT1-SIRT5).; Remark: the five human sirtuins are widely expressed in fetal and adult tissues.; Similarity: the H. sapiens sirtuin type proteins are closly related to yeast Sir2 proteins, which are regulating epigenetic gene silencing and as a possible antiaging effect, they suppresses recombination of rDNA.; Title: strong similarity to cDNA sirtuin type 4 protein SIRT4 - Homo sapiens; See PMID 10381378; uncharacterized protein 1494281 4984189 An09g06520 Aspergillus niger uncharacterized protein XP_059601472.1 1493127 D 5061 CDS An09g06530 4984190 join(1494646..1494870,1494953..1494976,1495044..1495958) I 1 NT_166525.1 Remark: Cyclin-dependent kinase 2 (Cdk2) controls the transition from the G1 to the S phase in the mammalian cell cycle.; Title: strong similarity to cyclin dependent kinase 2-alpha - Rattus rattus; deleted EC_number 2.7.1.37; See PMID 7862443; uncharacterized protein 1495958 4984190 An09g06530 Aspergillus niger uncharacterized protein XP_001393968.1 1494646 D 5061 CDS An09g06540 4984191 join(1496746..1497122,1497224..1497350,1497399..1497518) I 1 NT_166525.1 Function: the S. cerevisiae NNF1 is an essential yeast gene required for proper spindle orientation,nucleolar and nuclear envelope structure and mRNA export.; Phenotype: the S. cerevisiae NNF1 null mutant is inviable; cells depleted of Nnf1p or containing a temperature-sensitive nnf1 mutation have elongated microtubules and become bi- and multinucleate.; Remark: the systematic name of S. cerevisiae NNF1 is YJR112W.; Title: similarity to protein Nnf1 - Saccharomyces cerevisiae; See PMID 9247195; uncharacterized protein 1497518 4984191 An09g06540 Aspergillus niger uncharacterized protein XP_059601473.1 1496746 D 5061 CDS An09g06550 4984192 complement(join(1497599..1498862,1498952..1499130,1499267..1499329)) I 1 NT_166525.1 Title: similarity to hypothetical protein SPAC926.02 - Schizosaccharomyces pombe; uncharacterized protein 1499329 4984192 An09g06550 Aspergillus niger uncharacterized protein XP_059601474.1 1497599 R 5061 CDS An09g06560 84592088 complement(join(1499769..1499818,1499902..1499930,1500067..1500263,1500535..1500616,1500712..1500793,1501033..1501142,1501191..1501313,1501435..1501568)) I 1 NT_166525.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1501568 84592088 An09g06560 Aspergillus niger uncharacterized protein XP_059601475.1 1499769 R 5061 CDS An09g06570 4984194 join(1501668..1501718,1501788..1502098,1502654..1502839,1502942..1503023) I 1 NT_166525.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1503023 4984194 An09g06570 Aspergillus niger uncharacterized protein XP_059601476.1 1501668 D 5061 CDS An09g06580 4984195 join(1503880..1504197,1504274..1505275,1505340..1505633) I 1 NT_166525.1 Title: strong similarity to ras-GTPase-activating protein SH3-domain binding protein G3BP - Mus musculus; See PMID 9575347; uncharacterized protein 1505633 4984195 An09g06580 Aspergillus niger uncharacterized protein XP_001393973.1 1503880 D 5061 CDS An09g06590 4984196 join(1508005..1508265,1508365..1510212) I 1 NT_166525.1 Function: prokaryotes and eukaryotes respond to heat shock and other forms of environmental stress by inducing synthesis of heat-shock proteins.; Function: the sspB protein is a Hsp90 heat shock protein.; Gene-ID: sspB; Remark: the matched sequence of sspB from A. niger was identified by a BLAST search with the new EMBL entry CAA72292.; heat shock protein sspB-Aspergillus niger 1510212 sspB 4984196 sspB Aspergillus niger heat shock protein sspB-Aspergillus niger XP_001393974.1 1508005 D 5061 CDS An09g06600 84592089 join(1510990..1511237,1511332..1511392) I 1 NT_166525.1 Remark: blast hits result from repetitive sequences.; hypothetical protein 1511392 84592089 An09g06600 Aspergillus niger hypothetical protein XP_059601477.1 1510990 D 5061 CDS An09g06610 4984198 complement(join(1511930..1512906,1512967..1513425,1513495..1514230)) I 1 NT_166525.1 Title: strong similarity to hypothetical protein EAA26720.1 - Neurospora crassa; uncharacterized protein 1514230 4984198 An09g06610 Aspergillus niger uncharacterized protein XP_001393976.1 1511930 R 5061 CDS An09g06620 84592090 complement(join(1514665..1514700,1514792..1514811,1514873..1515041)) I 1 NT_166525.1 hypothetical protein 1515041 84592090 An09g06620 Aspergillus niger hypothetical protein XP_059601478.1 1514665 R 5061 CDS An09g06630 4984200 join(1518450..1519046,1519116..1520169,1520281..1520822) I 1 NT_166525.1 Function: analysis of N. crassa nuc-2 and nuc-1; nuc-2 strains transformed by the nuc-1+ gene suggests that phosphate directly affects the level or activity of the negative regulatory factor(s) controlling phosphorus acquisition.; Title: similarity to transcription activator nuc-1 -Neurospora crassa; nucleus; See PMID 2146493; uncharacterized protein 1520822 4984200 An09g06630 Aspergillus niger uncharacterized protein XP_059601479.1 1518450 D 5061 CDS An09g06640 4984201 complement(join(1521552..1522550,1522612..1523427,1523542..1523598,1523671..1523682)) I 1 NT_166525.1 Function: human TFIIE consists of two subunits TFIIE-alpha T2EA_HUMAN and TFIIE-beta T2EB_HUMAN and joins the preinitiation complex after RNA polymerase II and TFIIF.; Function: the general transcription factor TFIIE has an essential role in eukaryotic transcription initiation together with RNA polymerase II and other general factors.; Similarity: restricted to TFIIE alpha subunit.; Title: similarity to DNA-directed RNA polymerase III 82 KD subunit Rpc82 - Saccharomyces cerevisiae; nucleus; See PMID 8407894; uncharacterized protein 1523682 4984201 An09g06640 Aspergillus niger uncharacterized protein XP_001393979.1 1521552 R 5061 CDS An09g06650 4984202 join(1524187..1524450,1524544..1524718,1524802..1525643,1525725..1525820) I 1 NT_166525.1 Function: the core protein II is an bifunctional enzyme, that acts as mitochondrial processing peptidase as well as part of the respiration chain b/c1 complex.; Title: strong similarity to core protein II of ubiquinol--cytochrome c reductase CAA42214.1 - Bos primigenius taurus; localisation:mitochondrion; uncharacterized protein 1525820 4984202 An09g06650 Aspergillus niger uncharacterized protein XP_001393980.3 1524187 D 5061 CDS An09g06660 84592091 join(1527248..1527258,1527403..1527486,1527558..1527627) I 1 NT_166525.1 Title: questionable ORF; uncharacterized protein 1527627 84592091 An09g06660 Aspergillus niger uncharacterized protein XP_059601480.1 1527248 D 5061 CDS An09g06670 4984204 complement(join(1527938..1527992,1528134..1528806,1528885..1528981,1529039..1529057,1529125..1529149,1529223..1529304)) I 1 NT_166525.1 Function: S. cerevisiae enzyme is essential for mitochondrial function in the absence of Abf2p.; Function: it associated with mitochondrial DNA in vivo.; Function: it is a component of the mitochondrial nucleoid structure.; Function: it is required for maintenance of mtDNA.; Function: it may function as a member of the protein machinery for the mitochondrial inner membrane attachment site for mitochondrial DNA during replication and segregartion of the mitochondrial genome.; Title: strong similarity to suppressor gene of mitochondrial histone Yhm2 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9742088; uncharacterized protein 1529304 4984204 An09g06670 Aspergillus niger uncharacterized protein XP_003188787.1 1527938 R 5061 CDS An09g06680 4984205 complement(join(1531146..1531334,1531399..1531699,1531774..1532390,1532445..1532492,1532553..1532637,1532709..1532773,1532838..1532957)) I 1 NT_166525.1 Catalytic activity: converts Citrate + CoA <=> acetyl-CoA + H(2)O + oxaloacetate.; Function: up to 11-fold overproduction of citrate synthase did not increase the rate of citric acid production by the fungus, suggesting that citrate synthase contributes little to flux control in the pathway involved in citric acid biosynthesis by a non-commercial strain.; Gene-ID: citA; Localization: in addition to an N-terminal mitochondrial import signal, a peroxisomal target sequence (AKL) was found at the C-terminus of the protein, but it is unclear whether both signals are functional in vivo.; localisation:mitochondrion; See PMID 10689162; citrate synthase citA-Aspergillus niger 1532957 citA 4984205 citA Aspergillus niger citrate synthase citA-Aspergillus niger XP_001393983.1 1531146 R 5061 CDS An09g06690 84592092 join(1534907..1535026,1535211..1535420) I 1 NT_166525.1 Title: similarity to hypothetical protein related to potassium channel subunit MiRP3 B1D1.370 - Neurospora crassa; uncharacterized protein 1535420 84592092 An09g06690 Aspergillus niger uncharacterized protein XP_059601481.1 1534907 D 5061 CDS An09g06700 4984207 join(1535693..1535738,1535881..1536921,1537008..1537041,1537107..1537275,1537331..1537535,1537596..1537900) I 1 NT_166525.1 Function: many eukaryotic proteins that are known or supposed to bind single-stranded RNA contain one or more copies of a putative RNA-binding domain of about 90 amino acids.; Title: similarity to protein involved in regulation of nuclear pre-mRNA abundance Nrd1 - Saccharomyces cerevisiae; nucleus; See PMID 8943355; See PMID 9234673; uncharacterized protein 1537900 4984207 An09g06700 Aspergillus niger uncharacterized protein XP_001393985.3 1535693 D 5061 CDS An09g06710 4984208 complement(join(1539219..1539402,1539469..1540037,1540109..1540468,1540542..1540625,1540689..1540743,1540812..1540861)) I 1 NT_166525.1 Catalytic activity: it converts o-acetyl-l-homoserine + methanethiol = l-methionine + acetate.; Cofactor: pyridoxal phosphate.; Function: A. nidulans enzyme transforms o-acetylhomoserine into homocysteine.; Similarity: belongs to the trans-sulfuration enzymes family.; Title: strong similarity to O-acetylhomoserine (thiol)-lyase cysD - Aspergillus nidulans; cytoplasm; uncharacterized protein 1540861 4984208 An09g06710 Aspergillus niger uncharacterized protein XP_001393986.1 1539219 R 5061 CDS An09g06720 4984209 join(1541966..1542098,1542161..1542274,1542324..1542338,1542819..1543095,1543216..1543324) I 1 NT_166525.1 Remark: ORF might be questionable because of large intron.; Title: weak similarity to hypothetical protein B13I18.100 - Neurospora crassa; uncharacterized protein 1543324 4984209 An09g06720 Aspergillus niger uncharacterized protein XP_059601482.1 1541966 D 5061 CDS An09g06730 4984210 join(1545778..1545988,1546087..1547567) I 1 NT_166525.1 Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to lysine-specific high-affinity permease Lyp1 - Saccharomyces cerevisiae; plasma membrane; See PMID 9348664; uncharacterized protein 1547567 4984210 An09g06730 Aspergillus niger uncharacterized protein XP_001393988.1 1545778 D 5061 CDS An09g06740 4984211 join(1549760..1549933,1550033..1550288,1550342..1551932,1551999..1552104) I 1 NT_166525.1 Catalytic activity: ATP + a long-chain carboxylic acid + CoA <=> AMP + diphosphate + an acyl-CoA.; Function: S. cerevisiae Faa2 is involved in esterification, concomitant with transport, of endogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. It preferentially acts on c9:0-c13:0 fatty acids although c7:0-c17:0 fatty acids are tolerated. Its optimum activity is found at 25 degrees celsius.; Remark: alternate names for S. cerevisiae Faa2: Fam1 or YER015W.; Title: strong similarity to long-chain-fatty-acid--CoA ligase Faa2 - Saccharomyces cerevisiae; See PMID 8027063; See PMID 8206942; uncharacterized protein 1552104 4984211 An09g06740 Aspergillus niger uncharacterized protein XP_001393989.1 1549760 D 5061 CDS An09g06750 4984212 join(1552761..1553265,1553464..1553556,1553655..1553890) I 1 NT_166525.1 Title: strong similarity to hypothetical protein B13I18.120 - Neurospora crassa; uncharacterized protein 1553890 4984212 An09g06750 Aspergillus niger uncharacterized protein XP_001393990.1 1552761 D 5061 CDS An09g06760 4984213 complement(join(1554280..1555075,1555180..1555265)) I 1 NT_166525.1 Remark: alternate names for Drosophila eld: eyelid or osa.; Similarity: the ORF encoded protein shows significant similarity to the hypothetical protein B13I18. 20 Neurospora crassa.; Similarity: the similarities of the ORF encoded protein to hits with an e-Val less than 2e-11 are mainly based on repetitive structures.; Title: weak similarity to transcription factor eyelid eld - Drosophila melanogaster; uncharacterized protein 1555265 4984213 An09g06760 Aspergillus niger uncharacterized protein XP_001393991.1 1554280 R 5061 CDS An09g06770 4984214 complement(join(1555598..1558886,1559224..1559279)) I 1 NT_166525.1 Title: strong similarity to hypothetical protein B13I18.130 - Neurospora crassa; uncharacterized protein 1559279 4984214 An09g06770 Aspergillus niger uncharacterized protein XP_001393992.3 1555598 R 5061 CDS An09g06780 4984215 complement(join(1559906..1560024,1560080..1560813,1560868..1560992)) I 1 NT_166525.1 Remark: Depletion of the Candida boidinii PMP47 gene results in a retarded growth on oleate and a complete loss of growth on methanol, pmp47delta cells show reduced numbers peroxisomes. The activity of one of the methanol-induced peroxisome matrix enzymes,dihydroxyacetone synthase (DHAS), can not be detected.; Similarity: the peroxisomal membrane protein 47 (Pmp47) from Candida boidinii belongs to the mitochondrial carrier family.; Title: strong similarity to peroxisomal membrane protein 47 Pmp47 - Candida boidinii; peroxisome; See PMID 8698821; uncharacterized protein 1560992 4984215 An09g06780 Aspergillus niger uncharacterized protein XP_001393993.1 1559906 R 5061 CDS An09g06790 4984216 complement(join(1562482..1562676,1562754..1562981,1563039..1563086,1563169..1563292,1563528..1563538)) I 1 NT_166525.1 Gene-ID: sgrB;yptA; Similarity: strong similarity to the GTP-binding protein Rab1 from Homo sapiens.; See PMID 11489135; secretion related GTPase srgB-Aspergillus niger 1563538 sgrB 4984216 sgrB Aspergillus niger secretion related GTPase srgB-Aspergillus niger XP_001393994.1 1562482 R 5061 CDS An09g06800 4984217 complement(join(1564345..1564939,1564995..1565207,1565295..1565737,1565790..1565859,1565915..1566129,1566188..1566213,1566274..1566390,1566448..1566565,1566623..1566844,1566907..1567331,1567419..1567588,1567661..1567695)) I 1 NT_166525.1 Cofactor: Zinc.; Function: S. cerevisiae Ape2 is involved in the cellular supply of leucine from externally offered leucine-containing dipeptide substrates.; Remark: alternate names for S. cerevisiae Ape2: Aminopeptidase II, YscII, Lap1 or YKL157W.; Similarity: S. cerevisiae Ape2 belongs to peptidase family M1 (zinc metalloprotease) which is also known as the PepN subfamily.; Title: strong similarity to leucyl aminopeptidase Ape2 - Saccharomyces cerevisiae; See PMID 1765107; See PMID 3286257; See PMID 6352682; uncharacterized protein 1567695 4984217 An09g06800 Aspergillus niger uncharacterized protein XP_059601483.1 1564345 R 5061 CDS An09g06810 4984218 join(1568477..1568709,1568788..1569123,1569191..1569995) I 1 NT_166525.1 Complex: the SSL1 gene of S. cerevisiae encodes a subunit of the RNA polymerase II transcription factor TFIIH (factor b).; Title: strong similarity to subunit of transcription initiation factor TFIIH Ssl1 - Saccharomyces cerevisiae; nucleus; See PMID 11007479; See PMID 7891722; uncharacterized protein 1569995 4984218 An09g06810 Aspergillus niger uncharacterized protein XP_001393996.1 1568477 D 5061 CDS An09g06820 4984219 join(1570830..1571017,1571138..1571432) I 1 NT_166525.1 Title: similarity to hypothetical protein B17C10.80 - Neurospora crassa; uncharacterized protein 1571432 4984219 An09g06820 Aspergillus niger uncharacterized protein XP_001393997.1 1570830 D 5061 CDS An09g06830 4984220 complement(join(1572070..1572129,1572181..1572286,1572342..1572432,1572491..1572770,1572952..1573592,1573656..1574769,1574819..1574929,1575002..1575118)) I 1 NT_166525.1 Function: the Pumilio protein from D. melanogaster is involved in translational regulation of hunchback (hb) mRNA, which is essential for posterior patterning of the Drosophila embryo. This regulation is mediated by sequences in the 3'-untranslated region of hb mRNA (the Nanos response elements or NREs.). Nonos and Pumilio are the two important trans-acting factors.; Similarity: the ORF encoded protein belongs to the Pumilio/Mpt5 family.; Title: similarity to RNA binding protein Pumilio Pum - Drosophila melanogaster; cytoplasm; See PMID 10541556; See PMID 10662662; uncharacterized protein 1575118 4984220 An09g06830 Aspergillus niger uncharacterized protein XP_059601484.1 1572070 R 5061 CDS An09g06840 4984221 join(1577330..1577332,1577415..1577807,1577865..1579127) I 1 NT_166525.1 Function: the S. cerevisiae homolog Sly41p is likely to be involved in vesicular ER to Golgi transport. Sly41p was shown to suppress a functional loss of the essential gene YPT1, a member of the RAS superfamily involved in this particular transport step.; Similarity: S. cerevisiae Sly41p has similarity to the triose phosphate translocator family.; Title: strong similarity to protein involved in ER to Golgi transport Sly41 - Saccharomyces cerevisiae; uncharacterized protein 1579127 4984221 An09g06840 Aspergillus niger uncharacterized protein XP_059601485.1 1577330 D 5061 CDS An09g06850 4984222 join(1580132..1580246,1580307..1580330,1580386..1580437,1580492..1580506,1580559..1580581,1580646..1582527,1582584..1582686) I 1 NT_166525.1 Catalytic activity: NADH + ubiquinone <=> NAD(+) + ubiquinol.; Function: the NDUFS1 gene from Bos taurus encodes for the largest subunit of respiratory chain complex I and it is a component of the iron-sulfur (IP) fragment. It may form a part of the active site where NADH is oxidized.; Title: strong similarity to 78 kD subunit of NADH:ubiquinone reductase NDUFS1 - Bos taurus; localisation:mitochondrion; See PMID 2514801; uncharacterized protein 1582686 4984222 An09g06850 Aspergillus niger uncharacterized protein XP_001394000.1 1580132 D 5061 CDS An09g06860 4984223 complement(join(1583044..1583501,1583562..1583868,1583919..1584136,1584211..1584367)) I 1 NT_166525.1 Similarity: the ORF encoded protein shows significant similarity to the protein related to the mitotic apparatus protein p62 (protein B13N20. 180) from Neurospora crassa.; Title: similarity to hypothetical mitotic apparatus protein p62 related protein CAB91383.2 - Neurospora crassa; uncharacterized protein 1584367 4984223 An09g06860 Aspergillus niger uncharacterized protein XP_059601486.1 1583044 R 5061 CDS An09g06870 4984224 join(1585634..1588004,1588055..1588647) I 1 NT_166525.1 Complex: the S. pombe byr4 protein interacts with the GTPase Spg1, which is involved in the regulation of septation and constriction of the actomyosin ring for cell division in fission yeast. Spg1 is a member of the Ras superfamily.; Function: the S. pombe byr4 protein is involved in coordination between karyokinesis and cytokinesis in the cell division cycle.; Remark: null alleles of byr4 (S. pombe) cause cell cycle arrest in late mitosis and permit multiple rounds of septation.; Title: similarity to dosage-dependent cytokinesis inhibitor byr4p - Schizosaccharomyces pombe; See PMID 8682866; See PMID 9638658; See PMID 10196225; uncharacterized protein 1588647 4984224 An09g06870 Aspergillus niger uncharacterized protein XP_059601487.1 1585634 D 5061 CDS An09g06880 84592093 complement(join(1590640..1590723,1590894..1590920,1591005..1591286)) I 1 NT_166525.1 hypothetical protein 1591286 84592093 An09g06880 Aspergillus niger hypothetical protein XP_059601488.1 1590640 R 5061 CDS An09g06890 4984226 1594613..>1595050 I 1 NT_166525.1 Remark: C-terminally truncated ORF due to the end of contig.; Remark: alternate names for S. cerevisiae Mig2: Mlz1 or YGL209W.; Title: weak similarity to transcription co-repressor Mig2 - Saccharomyces cerevisiae [truncated ORF]; uncharacterized protein 1595050 4984226 An09g06890 Aspergillus niger uncharacterized protein XP_001394004.3 1594613 D 5061 CDS An14g00010 4986857 join(810..839,894..1161,1232..1554) I 1 NT_166529.1 Function: srgA mutants displayed a twofold increase in their hyphal diameter, unusual apical branching and strongly reduced protein secretion during growth on glucose.; Gene-ID: srgA; Similarity: strong similarity to the GTP-binding protein SAS1 from D. discoideum.; See PMID 11489135; secretion related GTPase srgA-Aspergillus niger 1554 srgA 4986857 srgA Aspergillus niger secretion related GTPase srgA-Aspergillus niger XP_001400630.1 810 D 5061 CDS An14g00020 4986858 join(2854..3610,3680..4380,4430..5158) I 1 NT_166529.1 Function: S. cerevisiae homolog is essential and an allelic form shows resistance to the drug diazaborine in S. cerevisiae.; Remark: S. cerevisiae homolog Afg2p is a AAA (ATPases associated to a variety of cellular activities) class ATPase similar to the CDC48 gene product.; Title: strong similarity to AAA class ATPase Afg2 -Saccharomyces cerevisiae; uncharacterized protein 5158 4986858 An14g00020 Aspergillus niger uncharacterized protein XP_059602213.1 2854 D 5061 CDS An14g00030 4986863 join(5668..5982,6039..6144,6198..6700) I 1 NT_166529.1 Complex: RNPS1 of H. sapiens is found in a single complex of approximately 335 kDa. Four other proteins of the complex were identified as the splicing-associated factors SRm160, DEK, the mRNA-associated shuttling protein Y14 and the mRNA export factor REF.; Function: Recombinant human RNPS1 expressed in baculovirus functionally synergizes with SR proteins and strongly activates splicing of both constitutively and alternatively spliced pre-mRNAs.; Remark: RNPS1 of H. sapiens is a RNA-binding protein.; Title: strong similarity to general activator of pre-mRNA splicing RNPS1 - Homo sapiens; nucleus; uncharacterized protein 6700 4986863 An14g00030 Aspergillus niger uncharacterized protein XP_001400632.1 5668 D 5061 CDS An14g00040 4986891 complement(join(6947..6988,7037..7183,7233..7351,7403..7487,7550..7637,7687..7809,7866..7948,8004..8128,8198..8395,8446..8728,8786..8986,9029..9125,9227..9388,9443..9535,9599..9696,9751..10054,10140..10620,10671..11211,11276..12505,12563..12805,12860..13339,13420..13516,13577..13729,13781..14176,14231..14535,14593..15218,15268..15853)) I 1 NT_166529.1 Function: A. nidulans uvsB and uvsD belong to the same epistasis group of DNA repair mutants and are likely to control cell cycle checkpoint responses to DNA damage and incomplete replication. They are also involved in septum formation and regulation of gene expression. UVSB probably functions as the central regulator of the A. nidulans DNA damage response.; Similarity: The A. nidulans uvsB gene is shown to encode a rad3/ATR homologue, a component of the nucleotide excision repairosome.; Title: strong similarity to ATM-related kinase required for DNA damage response uvsB - Aspergillus nidulans; uncharacterized protein 15853 4986891 An14g00040 Aspergillus niger uncharacterized protein XP_059602214.1 6947 R 5061 CDS An14g00050 4986895 join(16538..16615,16672..16780,16874..17018,17105..17302,17414..17663) I 1 NT_166529.1 Function: S. cerevisiae homolog Tad2p and S. c. Tad3p together convert adenosine at pos. 34 of tRNA-Ala to inosine.; Title: similarity to tRNA-specific adenosine deaminase Tad2 - Saccharomyces cerevisiae; uncharacterized protein 17663 4986895 An14g00050 Aspergillus niger uncharacterized protein XP_059602215.1 16538 D 5061 CDS An14g00060 4986861 complement(join(17675..17755,17838..18040,18098..18303,18357..18373,18439..18498)) I 1 NT_166529.1 Catalytic activity: NADH + ubiquinone = NAD(+) + ubiquinol.; Function: transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.; Pathway: oxidative phosphorylation, respiratory chain complex I.; Similarity: the N. crassa homolog is the 21 kDa subunit of NADH:ubiquinone oxidoreductase (complex I) and is a nuclear-coded component of its hydrophobic arm.; Title: strong similarity to 20.9 kD subunit of NADH:ubiquinone reductase - Neurospora crassa; localisation:mitochondrion; uncharacterized protein 18498 4986861 An14g00060 Aspergillus niger uncharacterized protein XP_001400635.1 17675 R 5061 CDS An14g00070 4986866 join(18952..19107,19313..19879) I 1 NT_166529.1 Title: weak similarity to hypothetical protein SPBC30D10.04 - Schizosaccharomyces pombe; uncharacterized protein 19879 4986866 An14g00070 Aspergillus niger uncharacterized protein XP_059602216.1 18952 D 5061 CDS An14g00080 4986855 complement(join(20342..21169,21229..22122)) I 1 NT_166529.1 Catalytic activity: S. cerevisiae homolog Srm1p is Gdp/GTP exchange factor for Gsp1p/Gsp2p.; Function: S. cerevisiae homolog is involved in yeast pheromone response pathway and in mRNA metabolism.; Remark: S. cerevisiae homolog alternative gene names: PRP20, MTR1.; Remark: contains regulator of chromosome condensation (RCC1) signature.; Title: strong similarity to pheromone response pathway suppressor Srm1 - Saccharomyces cerevisiae; nucleus; uncharacterized protein 22122 4986855 An14g00080 Aspergillus niger uncharacterized protein XP_001400637.1 20342 R 5061 CDS An14g00090 4986889 complement(22875..24830) I 1 NT_166529.1 Catalytic activity: catalyzes the reduction of 2,4 diamino-6-ribitylamino-4(3H)-pyrimidine 5'-phosphate by NADPH to yield DRTP.; Function: S. cerevisiae Rib7p is HTP reductase involved in riboflavin biosynthesis.; Pathway: third step of riboflavin biosynthesis.; Remark: significantly longer than S. cerevisiae homolog protein Rib7p.; Title: similarity to riboflavin biosynthesis protein Rib7 - Saccharomyces cerevisiae; uncharacterized protein 24830 4986889 An14g00090 Aspergillus niger uncharacterized protein XP_001400638.3 22875 R 5061 CDS An14g00100 4986856 complement(join(25392..25718,25778..26493,26552..27445,27578..27811,27917..28230,28305..28801)) I 1 NT_166529.1 Complex: S. cerevisiae homolog interacts with the Nsp1p complex which is involved in nucleocytoplasmic transport.; Function: S. cerevisiae homolog is required for nuclear pore formation.; Localization: S. cerevisiae homolog is localized in the nuclear pore complex.; Title: strong similarity to nucleoporin-interacting protein Nic96 - Saccharomyces cerevisiae; nucleus; uncharacterized protein 28801 4986856 An14g00100 Aspergillus niger uncharacterized protein XP_059602217.1 25392 R 5061 CDS An14g00110 4986862 join(29188..29511,29577..29744) I 1 NT_166529.1 Title: similarity to hypothetical protein YJL003w -Saccharomyces cerevisiae; uncharacterized protein 29744 4986862 An14g00110 Aspergillus niger uncharacterized protein XP_059602218.1 29188 D 5061 CDS An14g00120 84592897 join(30179..30228,30319..30427,30726..30787,30853..31171,31234..31431) I 1 NT_166529.1 hypothetical protein 31431 84592897 An14g00120 Aspergillus niger hypothetical protein XP_059602219.1 30179 D 5061 CDS An14g00130 84592898 join(31696..33126,33211..33936) I 1 NT_166529.1 Function: the S. pombe homolog encodes a nonreceptor type protein tyrosine phosphatase that negatively regulates mitosis.; Title: strong similarity to protein-tyrosine-phosphatase pyp1p - Schizosaccharomyces pombe; uncharacterized protein 33936 84592898 An14g00130 Aspergillus niger uncharacterized protein XP_059602220.1 31696 D 5061 CDS An14g00140 4986865 join(34709..35507,35577..36454) I 1 NT_166529.1 hypothetical protein 36454 4986865 An14g00140 Aspergillus niger hypothetical protein XP_059602221.1 34709 D 5061 CDS An14g00150 4986886 complement(join(37149..37212,37289..37848)) I 1 NT_166529.1 Similarity: the ORF shows strong similarity to EST an_3574 from Aspergillus niger.; Title: similarity to hypothetical protein B24H17.110 - Neurospora crassa; uncharacterized protein 37848 4986886 An14g00150 Aspergillus niger uncharacterized protein XP_001400644.1 37149 R 5061 CDS An14g00160 4986859 join(39008..39229,39312..39872,39969..41024) I 1 NT_166529.1 Catalytic activity: K. pneumoniae rbtK catalyzes phosphorylation of D-ribulose to D-ribulose-5-phosphate.; Function: the K. pneumoniae homolog is a D-ribulokinase; Pathway: pentose-phosphate pathway; Title: strong similarity to D-ribulokinase rbtK -Klebsiella pneumoniae; uncharacterized protein 41024 4986859 An14g00160 Aspergillus niger uncharacterized protein XP_001400645.1 39008 D 5061 CDS An14g00170 4986893 complement(join(41331..41416,41484..41719,41804..41967,42030..42962,43027..44867,44924..45062)) I 1 NT_166529.1 Function: one mechanism reported for H+ transport mediated by Ca2+ is an ATP-dependent Ca2+/H+ antiporter which is catalyzed by (Ca2+ + Mg2+)-ATPase in the plasma membrane.; Similarity: the S. cerevisiae homolog shows similarities to other Ca2+/H+ antiporter.; Title: strong similarity to hypothetical Ca2+/H+ antiporter YNL321w - Saccharomyces cerevisiae; plasma membrane; uncharacterized protein 45062 4986893 An14g00170 Aspergillus niger uncharacterized protein XP_059602222.1 41331 R 5061 CDS An14g00180 4986868 join(46230..46464,46553..47228,47305..47563) I 1 NT_166529.1 Complex: RPT6 is a protein of the 19S particle.; Function: RPT6 is an ATPase with regulatory function in the proteasome.; Localization: By immunofluorescence RPT6 was determined to be localized almost exclusively to the nucleus throughout the cell cycle.; Remark: The 26 S proteasome of eukaryotes consists of the 20S core protease and two 19S particles and is responsible for the degradation of proteins targeted for proteolysis by the ubiquitin system.; Remark: The two 19S particles mediate the binding and unfolding of a substrate protein before its transfer to the interior of the 20S core.; Title: strong similarity to proteasome 19S regulatory particle subunit Rpt6 - Saccharomyces cerevisiae; See PMID 10419517; See PMID 10688918; uncharacterized protein 47563 4986868 An14g00180 Aspergillus niger uncharacterized protein XP_001400647.1 46230 D 5061 CDS An14g00190 4986892 join(51811..53427,53510..53532,53588..53680,53745..53781) I 1 NT_166529.1 Title: weak similarity to hypothetical protein At2g17590 - Arabidopsis thaliana; uncharacterized protein 53781 4986892 An14g00190 Aspergillus niger uncharacterized protein XP_059602223.1 51811 D 5061 CDS An14g00200 4986860 54413..56740 I 1 NT_166529.1 Remark: the encoded protein shows also weak similarities to several ubiquitin fusion-degradation 1-like proteins.; Title: strong similarity to protein fragment SEQ ID NO:48474 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 56740 4986860 An14g00200 Aspergillus niger uncharacterized protein XP_059602224.1 54413 D 5061 CDS An14g00210 4986885 complement(join(57118..57720,57821..58171)) I 1 NT_166529.1 Complex: Yip1 specifically binds to the transport GTPases Ypt1p and Ypt31p.; Function: Yip1p has a role in recruiting the two GTPases Ypt1p and Ypt31p to Golgi target membranes in preparation for fusion.; Golgi; Localization: According to subcellular fractionation and indirect immunofluorescence, Yip1 is located to Golgi membranes at steady state.; Title: similarity to Golgi membrane protein Yip1 -Saccharomyces cerevisiae; See PMID 9724632; uncharacterized protein 58171 4986885 An14g00210 Aspergillus niger uncharacterized protein XP_001400650.1 57118 R 5061 CDS An14g00220 4986864 complement(join(58578..59785,59843..60029,60130..60246,60334..60366)) I 1 NT_166529.1 Title: strong similarity to hypothetical protein SPAC17C9.06 - Schizosaccharomyces pombe; uncharacterized protein 60366 4986864 An14g00220 Aspergillus niger uncharacterized protein XP_001400651.1 58578 R 5061 CDS An14g00230 4986871 join(60773..60799,60862..60941,61012..61732) I 1 NT_166529.1 Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.; Localization: UBC6 is an integral membrane protein that localizes to the endoplasmic reticulum (ER), with the catalytic domain facing the cytosol.; Pathway: ER degradation.; Remark: Ubiquitin-conjugating enzymes function in selective proteolysis pathways and catalyse the covalent attachment of ubiquitin to proteolytic substrates. S. cerevisiae Ubc6p is a ubiquitin conjugating enzyme targeting unfolded or misfolded ER lumenal proteins for retrograde transport across the ER membrane and subsequent degradation by the proteasome.; Title: strong similarity to ubiquitin conjugating enzyme Ubc6 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 8396728; uncharacterized protein 61732 4986871 An14g00230 Aspergillus niger uncharacterized protein XP_001400652.1 60773 D 5061 CDS An14g00240 4986867 join(62665..62748,62808..63481,63557..63797) I 1 NT_166529.1 Catalytic activity: Holocytochrome c = apocytochrome c + heme.; Remark: In the reverse direction, cyt-2 catalyses the attachment of heme to two cysteine residues in the protein, forming thioether links.; Similarity: cyt-2 shows homology to the yeast cytochrome c heme lyase.; Title: strong similarity to holocytochrome-c synthase cyt-2 - Neurospora crassa; See PMID 2572587; uncharacterized protein 63797 4986867 An14g00240 Aspergillus niger uncharacterized protein XP_001400653.1 62665 D 5061 CDS An14g00250 4986890 complement(join(64903..66285,66348..66713)) I 1 NT_166529.1 Title: strong similarity to hypothetical membrane protein YPL109c - Saccharomyces cerevisiae; uncharacterized protein 66713 4986890 An14g00250 Aspergillus niger uncharacterized protein XP_001400654.3 64903 R 5061 CDS An14g00260 4986878 complement(join(67446..68650,68731..68904,68962..69081,69139..69273,69359..69719)) I 1 NT_166529.1 Function: GDS (GDP dissociation stimulator) from bovine brain cytosol is a regulatory protein that stimulates the GDP/GTP exchange reaction of smg p21s (ras p21-like GTP-binding proteins) by stimulating the dissociation of GDP from and the subsequent binding of GTP to them.; Title: similarity to stimulatory GDP/GTP exchange protein GDS - Bos taurus; See PMID 1901951; See PMID 2118909; uncharacterized protein 69719 4986878 An14g00260 Aspergillus niger uncharacterized protein XP_059602225.1 67446 R 5061 CDS An14g00270 4986887 join(70607..70654,70735..71085) I 1 NT_166529.1 Title: weak similarity to dolichol-phosphate-mannose synthase DPM3 - Homo sapiens; uncharacterized protein 71085 4986887 An14g00270 Aspergillus niger uncharacterized protein XP_059602226.1 70607 D 5061 CDS An14g00280 4986882 complement(join(71876..71924,71986..72098,72169..72481,72546..72652,72886..72918)) I 1 NT_166529.1 Title: strong similarity to hypothetical protein YJR133w - Saccharomyces cerevisiae; uncharacterized protein 72918 4986882 An14g00280 Aspergillus niger uncharacterized protein XP_001400657.1 71876 R 5061 CDS An14g00290 4986875 complement(join(73942..74290,74355..74765,74836..75151,75215..75347)) I 1 NT_166529.1 Function: The mae1 gene encodes a permease involved in the uptake of L-malate, succinate and malonic acid.; Title: strong similarity to C4-dicarboxylate transport protein mae1p - Schizosaccharomyces pombe; See PMID 8750236; uncharacterized protein 75347 4986875 An14g00290 Aspergillus niger uncharacterized protein XP_001400658.3 73942 R 5061 CDS An14g00300 4986873 join(78064..78107,78192..78416,78470..78477,78528..78679,78737..78831,78892..79142,79237..79349) I 1 NT_166529.1 Function: Ayr1p of S. cerevisiae catalyzes the biosynthesis of phosphatidic acid through the dihydroxyacetone phosphate pathway by NADPH-dependent reduction of the intermediate 1-acyldihydroxyacetone phosphate.; Title: strong similarity to 1-acyldihydroxyacetone-phosphate reductase Ayr1 -Saccharomyces cerevisiae; See PMID 10617610; uncharacterized protein 79349 4986873 An14g00300 Aspergillus niger uncharacterized protein XP_059602227.1 78064 D 5061 CDS An14g00310 4986880 join(80033..80086,80173..80256,80325..80397,80464..80563,80623..81168,81231..81277,81330..81622,81697..81831) I 1 NT_166529.1 Catalytic activity: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate.; Localization: Immunocytochemical experiments suggest that succinyl-CoA synthetase from Neocallimastix frontalis is located in the hydrogenosomal matrix.; Pathway: Substrate level phosphorylation step of the tricarboxylic acid cycle.; Title: strong similarity to beta-succinyl CoA synthase precursor scsB - Neocallimastix frontalis; See PMID 9003318; uncharacterized protein 81831 4986880 An14g00310 Aspergillus niger uncharacterized protein XP_001400660.1 80033 D 5061 CDS An14g00320 4986894 complement(join(82278..83196,83263..83618,83730..83895,84024..84103)) I 1 NT_166529.1 hypothetical protein 84103 4986894 An14g00320 Aspergillus niger hypothetical protein XP_059602228.1 82278 R 5061 CDS An14g00330 4986874 join(85803..86152,86272..86370,86437..86504,86566..86909,86983..87052,87113..87915) I 1 NT_166529.1 Function: SFL1 of S. cerevisiae is involved in cell surface assembly and regulation of the gene related to flocculation (asexual cell aggregation). mutations in SFL1 of S. cerevisiae cause constitutive cell aggregation.; Similarity: the N-terminal section of SFL1 of S. cerevisiae is similar to the heat shock transcription factor (HSF) family. the C-terminal section of SFL1 of S. cerevisiae is similar to the myc family of helix-loop-helix transcription factors.; Title: strong similarity to flocculation suppression protein Sfl1 - Saccharomyces cerevisiae; See PMID 2697640; uncharacterized protein 87915 4986874 An14g00330 Aspergillus niger uncharacterized protein XP_001400662.1 85803 D 5061 CDS An14g00340 4986877 complement(join(88637..89144,89287..89471)) I 1 NT_166529.1 Remark: the similarity to the microtubule-associated protein homologue of D. melanogaster is due to repetitive sequence in the ORF.; Title: weak similarity to hypothetical protein AAN24427.1 - Bifidobacterium longum; uncharacterized protein 89471 4986877 An14g00340 Aspergillus niger uncharacterized protein XP_001400663.1 88637 R 5061 CDS An14g00350 4986869 complement(89981..90751) I 1 NT_166529.1 Title: similarity to hypothetical protein YPL107w -Saccharomyces cerevisiae; uncharacterized protein 90751 4986869 An14g00350 Aspergillus niger uncharacterized protein XP_001400664.1 89981 R 5061 CDS An14g00360 4986883 join(91190..91935,91989..92955) I 1 NT_166529.1 hypothetical protein 92955 4986883 An14g00360 Aspergillus niger hypothetical protein XP_001400665.3 91190 D 5061 CDS An14g00370 4986879 complement(join(93856..94290,94435..94593,94735..94781,94885..94918,95038..95040)) I 1 NT_166529.1 Remark: ribosomal proteins L13 of S. cerevisiae and A. thaliana were overexpressed in E. coli by tRNA-assisted overproduction.; Similarity: L13a of R. norvegicus is related to the S. cerevisiae ribosomal proteins that have been provisionally designated rp22 and rp23 and to the eubacterial and archaebacterial family of L13 ribosomal proteins.; Similarity: the ORF of A. niger is highly similar to several ESTs (AA787556; AI212136; AA784304; AI327985; ANI237050) of A. nidulans.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L13 - Rattus norvegicus; cytoplasm; See PMID 8198561; See PMID 10733889; 60S ribosomal protein eL13 95040 4986879 An14g00370 Aspergillus niger 60S ribosomal protein eL13 XP_001400666.1 93856 R 5061 CDS An14g00380 4986876 complement(96066..97505) I 1 NT_166529.1 Similarity: protein homologues are due to repetitive sequence of the ORF.; Title: weak similarity to hypothetical protein encoded by ORF L6202.3 - Leishmania major; uncharacterized protein 97505 4986876 An14g00380 Aspergillus niger uncharacterized protein XP_001400667.1 96066 R 5061 CDS An14g00390 4986888 99702..102686 I 1 NT_166529.1 Remark: a putative human homolog of soc-2 of C. elegans, SHOC-2, is expressed in all tissues assayed, and SHOC-2 protein is cytoplasmically localized.; Remark: soc-2 of C. elegans suppresses the activity of an activated form of the EGL-15 FGF receptor.; Remark: the c-terminus of the ORF of A. nidulans is conserved in non-characterized ORFs derived from several divergent species.; Similarity: Similarity to leucine-rich repeat proteins is due to high content of leucine.; Title: strong similarity to leucine-rich repeat protein soc-2 - Caenorhabditis elegans; cytoplasm; See PMID 9618511; uncharacterized protein 102686 4986888 An14g00390 Aspergillus niger uncharacterized protein XP_001400668.1 99702 D 5061 CDS An14g00400 4986881 complement(102941..104047) I 1 NT_166529.1 Title: similarity to hypothetical protein SPAC22E12.18 - Schizosaccharomyces pombe; uncharacterized protein 104047 4986881 An14g00400 Aspergillus niger uncharacterized protein XP_001400669.1 102941 R 5061 CDS An14g00410 4986884 join(105012..105507,105582..106290,106349..106411,106490..106628) I 1 NT_166529.1 Remark: a transcript of the actin-related protein of D. melanogaster was detected at all stages of development.; Remark: actin-related proteins (ARPs) have primary sequence homology to actin, have no homology to other proteins and, unlike the conventional actins, are clearly divergent.; Title: strong similarity to actin-related protein -Drosophila melanogaster; cytoskeleton; See PMID 8308899; uncharacterized protein 106628 4986884 An14g00410 Aspergillus niger uncharacterized protein XP_001400670.1 105012 D 5061 CDS An14g00420 4986898 join(107933..108195,108261..108791,108852..109128) I 1 NT_166529.1 Function: the RING finger/IBR motif-containing domains of HHARI of H. sapiens interact specifically with the ubiquitin-conjugating enzymes UbcH7 and UbcH8, but not with the unrelated ubiquitin-conjugating enzymes UbcH5 and UbcH1. it is not clear at present whether HHARI of H. sapiens serves simply as a substrate for UbcH7 or represents a protein with ubiquitin-protein ligase activity.; Similarity: HHARI of H. sapiens is a homologue of the Drosophila ring finger protein ariadne.; Title: similarity to UbcH 7-binding protein HHARI -Homo sapiens; See PMID 10521492; uncharacterized protein 109128 4986898 An14g00420 Aspergillus niger uncharacterized protein XP_001400671.1 107933 D 5061 CDS An14g00430 4986896 complement(join(109616..110346,110423..110522,110590..110718)) I 1 NT_166529.1 Function: the enzyme beta-hydroxybutyryl-coenzyme A (CoA) dehydrogenase (BHBD) of C. acetobutylicum catalyzes the reaction (s)-3-hydroxybutanoyl-CoA + NADP(+) = 3-acetoacetyl-CoA + NADPH.; Pathway: beta-hydroxybutyryl-coenzyme A (CoA) dehydrogenase (BHBD) of C. acetobutylicum is involved in butyryl-CoA synthesis.; Remark: beta-hydroxybutyryl-coenzyme A (CoA) dehydrogenase (BHBD) of C. acetobutylicum is a part of the BCS (butyryl-CoA synthesis) operon.; Remark: the ORF of A. niger is expressed in the ESTs BE760071 (97% identity) and BE759647 (96% identity).; Similarity: the enzyme beta-hydroxybutyryl-coenzyme A (CoA) dehydrogenase (BHBD) of C. acetobutylicum is similar to other 3-hydroxyacyl-CoA dehydrogenases.; Title: strong similarity to 3-hydroxybutyryl-CoA dehydrogenase BHBD - Clostridium acetobutylicum; See PMID 8655474; uncharacterized protein 110718 4986896 An14g00430 Aspergillus niger uncharacterized protein XP_001400672.1 109616 R 5061 CDS An14g00440 4986897 join(111030..111119,111181..111418,111473..113600,113788..114703) I 1 NT_166529.1 Remark: strong similarity to E. nidulans mdrA, drug resistance protein.; Title: similarity to topoisomerase I interacting factor 1 Tof1 - Saccharomyces cerevisiae; See PMID 10028183; uncharacterized protein 114703 4986897 An14g00440 Aspergillus niger uncharacterized protein XP_059602229.1 111030 D 5061 CDS An14g00450 84592899 115383..116657 I 1 NT_166529.1 Title: weak similarity to filaggrin MMFIL - Mus musculus; See PMID 3680218; uncharacterized protein 116657 84592899 An14g00450 Aspergillus niger uncharacterized protein XP_059602230.1 115383 D 5061 CDS An14g00460 4986900 117140..118570 I 1 NT_166529.1 Catalytic activity: betaine aldehyde + NAD(+) + H(2)O = betaine + NADH.; Pathway: osmoregulatory choline-glycine betaine pathway.; Remark: the E. coli protein is a soluble NAD-dependent betaine aldehyde-specific dehydrogenase.; Title: weak similarity to betaine aldehyde dehydrogenase badH - Escherichia coli; See PMID 1879697; See PMID 1956285; uncharacterized protein 118570 4986900 An14g00460 Aspergillus niger uncharacterized protein XP_001400675.1 117140 D 5061 CDS An14g00470 84592900 join(120443..121034,121141..121184) I 1 NT_166529.1 Title: weak similarity to hypothetical proline-rich protein T20E23.180 - Arabidopsis thaliana; uncharacterized protein 121184 84592900 An14g00470 Aspergillus niger uncharacterized protein XP_059602231.1 120443 D 5061 CDS An14g00480 4986902 complement(join(121555..122776,122844..122931,122990..123116)) I 1 NT_166529.1 Remark: the S. cerevisiae transcription factor IIH (TFIIH) is essential both for transcription by RNA polymerase II (RNAP II) and for nucleotide excision repair (NER) of damaged DNA.; Remark: the systematic name for TFB2 of S. cerevisiae is YPL122c.; Title: strong similarity to subunit of transcription initiation factor TFIIH Tfb2 - Saccharomyces cerevisiae; nucleus; See PMID 9118947; See PMID 11007479; uncharacterized protein 123116 4986902 An14g00480 Aspergillus niger uncharacterized protein XP_001400677.1 121555 R 5061 CDS An14g00490 4986903 join(123379..123405,123470..123510,123755..123833,123882..123924,123987..124159,124282..124300,124354..124432,124504..124579) I 1 NT_166529.1 Remark: novel protein similar to (predicted) human,plant, worm, yeast and archaea bacterial proteins.; Title: strong similarity to hypothetical protein SPBC31F10.02 - Schizosaccharomyces pombe; uncharacterized protein 124579 4986903 An14g00490 Aspergillus niger uncharacterized protein XP_059602232.1 123379 D 5061 CDS An14g00500 4986904 complement(join(125038..125486,125554..129024,129068..129479)) I 1 NT_166529.1 Remark: similarity to Superfamily I DNA helicases and helicase subunits.; Remark: weak similarity to ATPases associated with various cellular activities.; Title: strong similarity to hypothetical At2g38770 -Arabidopsis thaliana; uncharacterized protein 129479 4986904 An14g00500 Aspergillus niger uncharacterized protein XP_059602233.1 125038 R 5061 CDS An14g00510 4986905 join(129753..129992,130082..130160,130213..130331,130389..131075,131129..131278,131334..131647,131704..132130) I 1 NT_166529.1 Remark: in vivo and in vitro experiments demonstrate that human p84 binds preferentially to the functionally active, hypophosphorylated form of p110RB.; Remark: the amino terminus of p110RB may function in part to facilitate the binding of growth promoting factors at subnuclear regions actively involved in RNA metabolism.; Title: strong similarity to protein p84 - Homo sapiens; See PMID 7525595; uncharacterized protein 132130 4986905 An14g00510 Aspergillus niger uncharacterized protein XP_001400680.1 129753 D 5061 CDS An14g00520 4986906 join(141196..141791,141849..141986,142050..142687,142744..143114) I 1 NT_166529.1 Remark: expression was completely lacking in leaves and flowers.; Remark: in common sunflower Hahr1 expression was primarily found in dry seeds, hypocotyls and roots at stages associated with early developmental events.; Title: similarity to root-specific homeotic protein HRS1 - Helianthus annuus; See PMID 9322741; See PMID 10873798; uncharacterized protein 143114 4986906 An14g00520 Aspergillus niger uncharacterized protein XP_059602234.1 141196 D 5061 CDS An14g00530 4986907 join(144573..144732,144825..144920,144974..145050) I 1 NT_166529.1 Remark: in S. cerevisiae was shown that each molecule of protein contains 10 +/- 2 Cu(I).; Remark: the C-X-C repeats may coordinate copper binding.; Title: similarity to Cu-binding metallothionein CRD2 - Candida albicans; See PMID 10411649; See PMID 10940034; uncharacterized protein 145050 4986907 An14g00530 Aspergillus niger uncharacterized protein XP_001400682.1 144573 D 5061 CDS An14g00540 4986908 join(146338..146789,146851..147185,147242..149160,149217..149324) I 1 NT_166529.1 Remark: coat proteins of approximately 100-kD (adaptins) are components of the adaptor complexes which link clathrin to receptors in coated vesicles.; Title: strong similarity to alpha-adaptin C - Mus musculus; See PMID 10873829; See PMID 2564002; uncharacterized protein 149324 4986908 An14g00540 Aspergillus niger uncharacterized protein XP_001400683.1 146338 D 5061 CDS An14g00550 4986909 complement(149600..150415) I 1 NT_166529.1 Title: strong similarity to hypothetical protein YBL036c - Saccharomyces cerevisiae; uncharacterized protein 150415 4986909 An14g00550 Aspergillus niger uncharacterized protein XP_001400684.1 149600 R 5061 CDS An14g00560 4986910 join(<153865..155761,155772..157283,157429..158063) I 1 NT_166529.1 Remark: N-terminal truncated orf due to end of contig.; Remark: the protein shares similarity with histon deacylases.; Title: similarity to hypothetical protein YPL116w -Saccharomyces cerevisiae [truncated ORF]; See PMID 8962081; uncharacterized protein 158063 4986910 An14g00560 Aspergillus niger uncharacterized protein XP_059602235.1 153865 D 5061 CDS An14g00570 4986911 complement(158754..159824) I 1 NT_166529.1 Catalytic activity: 5,10-Methylenetetrahydrofolate + dUMP = Dihydrofolate + dTMP.; Pathway: Pyrimidine metabolism; One carbon pool by folate; Folate biosynthesis.; Remark: mutant TS cDNA can be used in gene therapy to transfer drug resistance to human haematopoietic progenitors, thus allowing dose-intense therapy in cancer patients by protecting normal cells and preventing dose-limiting myelotoxicity.; Title: strong similarity to thymidylate synthase CATSA - Candida albicans; See PMID 10840069; See PMID 10847455; See PMID 2646281; uncharacterized protein 159824 4986911 An14g00570 Aspergillus niger uncharacterized protein XP_001400686.1 158754 R 5061 CDS An14g00580 4986912 complement(join(160082..160265,160315..160502,160549..160626,160677..160734,160780..161100,161165..161248,161301..161551,161615..161692)) I 1 NT_166529.1 Catalytic activity: tRNA guanine + queuine = tRNA queuine + guanine.; Function: by similarity the enzyme exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-asp, -asn, -his and -tyr). after this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-y1)amino)methyl)-7 -deazaguanosine).; Remark: as cofactor it binds an requires by similarity zinc and magnesium for activity.; Remark: the enzyme also catalyses the exchange of precursors of queuine and of guanine itself for guanine located in the first position of certain tRNA anticodons.; Similarity: the enzyme belongs to the queuine tRNA-ribosyltransferase family.; Title: strong similarity to queuine tRNA-ribosyltransferase tgt - Zymomonas mobilis; See PMID 8654383; See PMID 7665516; uncharacterized protein 161692 4986912 An14g00580 Aspergillus niger uncharacterized protein XP_001400687.3 160082 R 5061 CDS An14g00590 4986913 join(162576..162641,162697..162829,162876..162951,162998..163079,163123..163225,163287..163690,163742..163911,163968..164052,164120..164417,164506..164678,164762..164872) I 1 NT_166529.1 Remark: agrobacterium vitis is a common pathogen of grapevine. Most strains utilize tartrate, an abundant compound in grapevine.; Title: similarity to tartrate transport protein ttuB - Agrobacterium vitis; See PMID 8672817; uncharacterized protein 164872 4986913 An14g00590 Aspergillus niger uncharacterized protein XP_059602236.1 162576 D 5061 CDS An14g00600 4986914 complement(join(169337..169461,169555..169745,170203..171281)) I 1 NT_166529.1 hypothetical protein 171281 4986914 An14g00600 Aspergillus niger hypothetical protein XP_001400689.3 169337 R 5061 CDS An14g00610 4986915 complement(join(172373..172629,172787..172889,173024..173098,173158..173249,173293..173405,173452..173749,173900..173993,174098..174172,174372..174429,174643..174710,174825..174898,175101..175124,175422..175479,175662..175878,175942..176452,176569..176986)) I 1 NT_166529.1 hypothetical protein 176986 4986915 An14g00610 Aspergillus niger hypothetical protein XP_001400690.3 172373 R 5061 CDS An14g00620 4986916 join(178750..178944,179019..179765,179825..180058) I 1 NT_166529.1 Catalytic activity: release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.; Remark: Enzyme with aminopeptidase activity - used in bread or dough-improving compsns., and to reduce the bitter taste of proteins or protein hydrolysates for foodstuffs, partic. cheese or cocoa.; Remark: as a cofactor of the reaction is zinc required.; Title: strong similarity to aminopeptidase from patent WO9628542-A1 - Aspergillus oryzae; See PMID 8175799; See PMID 1550363; uncharacterized protein 180058 4986916 An14g00620 Aspergillus niger uncharacterized protein XP_001400691.1 178750 D 5061 CDS An14g00630 4986917 join(180938..181992,182160..182385) I 1 NT_166529.1 Catalytic activity: adenosine 3',5'-bisphosphate + H(2)O <=> adenosine 5'-phosphate + phosphate.; Pathway: sulfur metabolism.; Remark: dephosphorylates 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS) intermediates of the sulfate assimilation pathway.; Title: strong similarity to salt tolerance protein Met22 - Saccharomyces cerevisiae; See PMID 7809627; See PMID 8393782; uncharacterized protein 182385 4986917 An14g00630 Aspergillus niger uncharacterized protein XP_059602237.1 180938 D 5061 CDS An14g00640 4986918 join(182980..182989,183076..183286,183386..183825,183885..184105) I 1 NT_166529.1 Title: strong similarity to hypothetical protein EAA61679.1 - Aspergillus nidulans; uncharacterized protein 184105 4986918 An14g00640 Aspergillus niger uncharacterized protein XP_059602238.1 182980 D 5061 CDS An14g00650 84592901 join(185552..185790,185833..185968) I 1 NT_166529.1 hypothetical protein 185968 84592901 An14g00650 Aspergillus niger hypothetical protein XP_059602239.1 185552 D 5061 CDS An14g00660 4986920 join(186076..187846,187899..188083,188143..188309,188367..189270) I 1 NT_166529.1 Catalytic activity: UDP-N-acetyl-D-glucosamine + [1,4-(N-Acetyl-beta-D-glucosaminyl)]n = UDP + [1,4-(N-Acetyl-beta-D-glucosaminyl)]n+1.; Pathway: chsA of E. nidulans is involved in aminosugar metabolism.; Remark: the chsA disruptant of the E. nidulans grew as well as the wild-type strain, but the chsB disruptant had severe growth defects that could not be overcome by the addition of 1. 2M sorbitol as an osmotic stabilizer. these findings suggested that chsB but not chsA is essential for hyphal growth.; Title: strong similarity to chitin synthase chsA -Aspergillus nidulans; See PMID 7765508; See PMID 10906951; See PMID 1731323; uncharacterized protein 189270 4986920 An14g00660 Aspergillus niger uncharacterized protein XP_001400695.3 186076 D 5061 CDS An14g00670 4986921 complement(join(189553..190113,190176..190299,190354..190775,190835..190934,190991..191064,191118..191216,191272..191547)) I 1 NT_166529.1 Catalytic activity: a Monocarboxylic acid amide + H2O = a Monocarboxylate + NH3.; Pathway: Arginine and proline metabolism; Phenylalanine metabolism; Tryptophan metabolism; Cyanoamino acid metabolism.; Remark: the enzyme acts on carbon-nitrogen bonds,other than peptide bonds In linear amides.; Title: strong similarity to acetamidase amdS -Aspergillus nidulans; See PMID 3036667; uncharacterized protein 191547 4986921 An14g00670 Aspergillus niger uncharacterized protein XP_001400696.1 189553 R 5061 CDS An14g00680 4986922 complement(join(192350..192661,192719..192798,192848..193076,193132..193241,193293..193373,193464..193619,193830..193973,194057..194171)) I 1 NT_166529.1 Remark: the protein is probably responsible for the uptake of zinc and cadmium ions.; Title: strong similarity to heavy metal ion resistance protein Zrc1 - Saccharomyces cerevisiae; See PMID 8720066; See PMID 2693940; uncharacterized protein 194171 4986922 An14g00680 Aspergillus niger uncharacterized protein XP_059602240.1 192350 R 5061 CDS An14g00690 4986923 complement(join(194387..195771,195908..195941,195997..196422,196483..196674)) I 1 NT_166529.1 Catalytic activity: 2 H2O2 = O2 + 2 H2O.; Function: the A. nidulans homolog catA is a catalase, functioning to protect cells from different reactive oxygen species.; Induction: A. nidulans catA is induced during oxidative stress and in asexual sporulation.; Remark: as cofactors acts manganese and heme.; Title: strong similarity to catalase A catA -Aspergillus nidulans; See PMID 8598056; See PMID 10589732; uncharacterized protein 196674 4986923 An14g00690 Aspergillus niger uncharacterized protein XP_059602241.1 194387 R 5061 CDS An14g00700 4986924 complement(join(197281..197305,197459..197769,197838..198354,198414..198858,198987..199347)) I 1 NT_166529.1 Title: strong similarity to hypothetical ATPase HFN2B - Haematobia irritans; See PMID 8551518; uncharacterized protein 199347 4986924 An14g00700 Aspergillus niger uncharacterized protein XP_001400699.3 197281 R 5061 CDS An14g00710 4986925 complement(join(200248..201162,201241..201996,202364..202393,202717..202722)) I 1 NT_166529.1 Remark: required for polarized morphogenesis in response to pheromone signal.; Title: strong similarity to bud emergence mediator Bem1 - Saccharomyces cerevisiae; See PMID 1538785; uncharacterized protein 202722 4986925 An14g00710 Aspergillus niger uncharacterized protein XP_059602242.1 200248 R 5061 CDS An14g00720 84592902 join(205226..205374,205549..205579) I 1 NT_166529.1 hypothetical protein 205579 84592902 An14g00720 Aspergillus niger hypothetical protein XP_059602243.1 205226 D 5061 CDS An14g00730 84592903 complement(join(206140..206151,206204..206261,206600..206625,206657..206801,207050..207093)) I 1 NT_166529.1 hypothetical protein 207093 84592903 An14g00730 Aspergillus niger hypothetical protein XP_059602244.1 206140 R 5061 CDS An14g00740 4986928 complement(join(208346..208562,208616..209876,209933..210005)) I 1 NT_166529.1 Title: similarity to hypothetical protein T16B24.2 -Arabidopsis thaliana; uncharacterized protein 210005 4986928 An14g00740 Aspergillus niger uncharacterized protein XP_001400703.1 208346 R 5061 CDS An14g00750 4986929 join(210526..210626,210769..210904,210956..212590) I 1 NT_166529.1 Title: similarity to defective in vacuolar protein sorting protein Vps36 - Saccharomyces cerevisiae; See PMID 8649377; See PMID 9265642; uncharacterized protein 212590 4986929 An14g00750 Aspergillus niger uncharacterized protein XP_001400704.1 210526 D 5061 CDS An14g00760 4986930 213027..215216 I 1 NT_166529.1 Similarity: the predicted ORF shows weak similarity to some neurofilament proteins.; hypothetical protein 215216 4986930 An14g00760 Aspergillus niger hypothetical protein XP_001400705.3 213027 D 5061 CDS An14g00770 4986931 complement(join(215540..216109,216283..216689,216784..217093)) I 1 NT_166529.1 hypothetical protein 217093 4986931 An14g00770 Aspergillus niger hypothetical protein XP_059602245.1 215540 R 5061 CDS An14g00780 4986932 join(217950..218114,218197..218346,218402..218506) I 1 NT_166529.1 Title: similarity to hypothetical protein PH0854 -Pyrococcus horikoshii; uncharacterized protein 218506 4986932 An14g00780 Aspergillus niger uncharacterized protein XP_001400707.1 217950 D 5061 CDS An14g00790 84592904 complement(join(219205..219349,219468..219514,219881..220045)) I 1 NT_166529.1 hypothetical protein 220045 84592904 An14g00790 Aspergillus niger hypothetical protein XP_059602246.1 219205 R 5061 CDS An14g00800 4986934 223979..226963 I 1 NT_166529.1 Similarity: the similarities are due to repetetive sequences.; Title: similarity to hypothetical protein CAC38347.1 - Schizosaccharomyces pombe; uncharacterized protein 226963 4986934 An14g00800 Aspergillus niger uncharacterized protein XP_001400709.1 223979 D 5061 CDS An14g00810 4986935 complement(join(228113..228475,228545..229079,229349..229482)) I 1 NT_166529.1 Title: strong similarity to hypothetical protein EAA61688.1 - Aspergillus nidulans; uncharacterized protein 229482 4986935 An14g00810 Aspergillus niger uncharacterized protein XP_059602247.1 228113 R 5061 CDS An14g00820 4986936 join(230392..230439,230576..230700,230744..230807) I 1 NT_166529.1 Title: weak similarity to subunit K of the dimeric form of mitochondrial F1F0-ATP synthase Atp19 -Saccharomyces cerevisiae; uncharacterized protein 230807 4986936 An14g00820 Aspergillus niger uncharacterized protein XP_059602248.1 230392 D 5061 CDS An14g00830 4986937 join(231406..231830,231974..232038,232192..232376) I 1 NT_166529.1 Function: PPT1 of B. ammoniagenes belongs to the group of holo-acyl carrier protein synthases (ACPS), that transfer the 4'-phosphopantetheine (4'-PP) moiety from coenzyme A (CoA) to Ser-36 of acyl carrier protein (ACP).; Function: PPT1 of B. ammoniagenes in vitro activates fatty acid synthase apoFAS-A.; Similarity: the ORF shows similarity to holo-[acyl-carrier-protein] synthase from some species.; Title: similarity to phosphopantethiene protein transferase PPT1 - Brevibacterium ammoniagenes; See PMID 9346306; uncharacterized protein 232376 4986937 An14g00830 Aspergillus niger uncharacterized protein XP_059602249.1 231406 D 5061 CDS An14g00840 4986938 join(232544..232702,232771..233538) I 1 NT_166529.1 Catalytic activity: L-Histidinol phosphate + H2O = L-Histidinol + Orthophosphate; Function: catalyzes ninth step in histidine biosynthetic pathway.; Pathway: histidine biosynthesis.; Title: strong similarity to histidinol-phosphatase His2 - Saccharomyces cerevisiae; See PMID 8056323; uncharacterized protein 233538 4986938 An14g00840 Aspergillus niger uncharacterized protein XP_001400713.1 232544 D 5061 CDS An14g00850 4986939 join(234051..234178,234343..234407,234495..234555,234626..234692) I 1 NT_166529.1 Catalytic activity: peptidylproline (omega=180) = peptidylproline (omega=0).; Function: FKBP12 of yeast is a peptidyl-prolyl cis-trans isomerase and binds rapamycin.; Title: strong similarity to peptidyl-prolyl isomerase Fpr1 - Saccharomyces cerevisiae; See PMID 8674674; See PMID 9315655; See PMID 9371805; uncharacterized protein 234692 4986939 An14g00850 Aspergillus niger uncharacterized protein XP_001400714.3 234051 D 5061 CDS An14g00860 4986940 complement(join(235072..235214,235282..235417,235507..235793,235877..236130,236197..236287,236339..236406,236458..236576,236634..236748,236806..237341)) I 1 NT_166529.1 Catalytic activity: diacylglycerol + H2O = monoacylglycerol + a carboxylate.; Catalytic activity: triacylglycerol + H2O = diacylglycerol + a carboxylate.; Function: the LIP5 gene product from Candida rugosa hydrolyzes triacylglycerols into fatty acids and glycerol.; Title: strong similarity to triacylglycerol lipase Lip5 - Candida rugosa; See PMID 10473391; uncharacterized protein 237341 4986940 An14g00860 Aspergillus niger uncharacterized protein XP_001400715.1 235072 R 5061 CDS An14g00870 4986941 complement(238421..240340) I 1 NT_166529.1 Title: weak similarity to hypothetical protein K06A9.1a - Caenorhabditis elegans; uncharacterized protein 240340 4986941 An14g00870 Aspergillus niger uncharacterized protein XP_001400716.1 238421 R 5061 CDS An14g00880 4986942 complement(join(241464..242645,242702..242767)) I 1 NT_166529.1 Function: the S. cerevisiae MSP1 protein is involved in mitochondrial membrane protein sorting.; Localization: the S. cerevisiae MSP1 protein belongs to the mitochondrial outer membrane.; Title: strong similarity to intra-mitochondrial sorting protein Msp1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8226973; uncharacterized protein 242767 4986942 An14g00880 Aspergillus niger uncharacterized protein XP_001400717.1 241464 R 5061 CDS An14g00890 4986943 join(243171..244071,244126..244563,244617..244840) I 1 NT_166529.1 Title: similarity to nucleolar phosphoprotein p130 -Homo sapiens; nucleus; See PMID 7657714; uncharacterized protein 244840 4986943 An14g00890 Aspergillus niger uncharacterized protein XP_001400718.1 243171 D 5061 CDS An14g00900 4986944 join(245563..247302,247355..247542,247601..247742,247819..247927,248018..248829) I 1 NT_166529.1 Function: Mcd4 is involved in cell wall integrity in yeast.; Function: the S. cerevisiae MCD4 encodes a conserved component of the GPI anchor synthesis pathway.; Localization: protein seems to be localized as well in the ER as in the vacuole.; Title: strong similarity to glycosylphosphatidylinositol anchor synthesis protein Mcd4 - Saccharomyces cerevisiae; vacuole; See PMID 10069808; See PMID 10514566; uncharacterized protein 248829 4986944 An14g00900 Aspergillus niger uncharacterized protein XP_001400719.1 245563 D 5061 CDS An14g00910 84592905 join(250465..250480,250589..250668,250798..250980,251080..251284,251402..251652) I 1 NT_166529.1 hypothetical protein 251652 84592905 An14g00910 Aspergillus niger hypothetical protein XP_059602250.1 250465 D 5061 CDS An14g00920 4986946 join(251963..252093,252293..252317,252469..252555,252669..252790,252865..253592,253660..253732,253795..254223,254278..254460,254510..255490,255569..255613,255768..255825) I 1 NT_166529.1 Remark: disruption of cutinase gene in Fusarium solani pisi drastically decreased its virulence.; Remark: the ORF encoded transcription factor belongs to the fungal Cys6Zn2 binuclear cluster family.; Title: strong similarity to cutinase transcription factor 1 CTF1-alpha - Fusarium solani; nucleus; See PMID 7753774; See PMID 9139694; uncharacterized protein 255825 4986946 An14g00920 Aspergillus niger uncharacterized protein XP_059602251.1 251963 D 5061 CDS An14g00930 4986947 join(256393..256587,256686..257729,257798..257860) I 1 NT_166529.1 Catalytic activity: Cystathionine + H(2)O <=> L-homocysteine + NH(3) + pyruvate.; Cofactor: pyridoxal-phosphate.; Pathway: the cystathionine beta-lyase MetG from Emericella nidulans is involved in the methionine, cysteine, selenoamino acid, nitrogen, and sulfur metabolism.; Title: strong similarity to cystathionine beta-lyase metG - Aspergillus nidulans; See PMID 10467009; See PMID 2653822; uncharacterized protein 257860 4986947 An14g00930 Aspergillus niger uncharacterized protein XP_001400722.1 256393 D 5061 CDS An14g00940 4986948 join(258654..258826,258928..259717) I 1 NT_166529.1 Title: strong similarity to hypothetical protein SPBC365.16 - Schizosaccharomyces pombe; uncharacterized protein 259717 4986948 An14g00940 Aspergillus niger uncharacterized protein XP_001400723.1 258654 D 5061 CDS An14g00950 4986949 complement(join(260896..261915,261970..262018,262067..262254,262301..262364,262416..262534)) I 1 NT_166529.1 EC:1.6.99.-.; Function: the Fre2 protein of S. cerevisiae is involved in iron uptake.; Induction: the expression of the FRE2 gene in S. cerevisiae becomes induced by iron-deprivation.; Remark: ORF may be a pseudogene, the database proteins are all longer at the N-terminus.; Title: similarity to ferric/cupric reductase Fre2 -Saccharomyces cerevisiae; See PMID 8164662; See PMID 8861201; See PMID 11120744; uncharacterized protein 262534 4986949 An14g00950 Aspergillus niger uncharacterized protein XP_059602252.1 260896 R 5061 CDS An14g00960 4986950 complement(join(263773..264366,264431..265318,265380..265490)) I 1 NT_166529.1 Catalytic activity: O3-acetyl-L-serine+H(2)S<=>L-cysteine+acetate.; Cofactor: pyridoxal-phosphate.; Pathway: the last enzymatic step for L-cysteine biosynthesis is catalyzed by the cysteine synthase B from Spinacia oleracea.; Title: similarity to chloroplast cysteine synthase B precursor cysk - Spinacia oleracea; See PMID 8405359; See PMID 1375015; uncharacterized protein 265490 4986950 An14g00960 Aspergillus niger uncharacterized protein XP_059602253.1 263773 R 5061 CDS An14g00970 4986951 join(266386..266547,266603..266736,266789..267582,267648..267837,267955..268095,268151..268463) I 1 NT_166529.1 Induction: the S. pombe fnx1 gene expression is induced during starvation.; Title: strong similarity to multidrug resistance protein fnx1p - Schizosaccharomyces pombe; See PMID 9710608; uncharacterized protein 268463 4986951 An14g00970 Aspergillus niger uncharacterized protein XP_059602254.1 266386 D 5061 CDS An14g00980 4986952 complement(268881..271070) I 1 NT_166529.1 Remark: N-terminally no significant similarities to database proteins.; Title: similarity to protein TRIAD3 - Homo sapiens; See PMID 10422847; uncharacterized protein 271070 4986952 An14g00980 Aspergillus niger uncharacterized protein XP_001400727.1 268881 R 5061 CDS An14g00990 4986953 complement(join(272629..273954,274009..274417,274473..274860,274909..274998,275052..275160,275222..275449,275526..275681)) I 1 NT_166529.1 Catalytic activity: 3-hydroxyacyl-CoA dehydrogenase: (S)-3-hydroxyacyl-CoA+NAD(+)<=>3-oxoacyl-CoA+NADH; Catalytic activity: enoyl-CoA hydratase: (3S)-3-hydroxyacyl-CoA<=>trans-2(or 3)-enoyl-CoA+H(2)O; Pathway: the trifunctional protein fox-2 from N. crassa is involved in the beta-oxidation of fatty acids.; Remark: the fox-2 protein from N. crassa carries three enzyme activities: 3-hydroxyacyl-CoA dehydrogenase; 3-hydroxyacyl-CoA epimerase; enoyl-CoA hydratase.; Title: strong similarity to trifunctional protein of the beta-oxidation fox-2 - Neurospora crassa; See PMID 1830049; See PMID 7715608; uncharacterized protein 275681 4986953 An14g00990 Aspergillus niger uncharacterized protein XP_001400728.1 272629 R 5061 CDS An14g01000 4986954 join(276706..276852,276936..277336,277553..277713,277769..277932) I 1 NT_166529.1 Title: strong similarity to hypothetical protein CAB52731.1 - Schizosaccharomyces pombe; uncharacterized protein 277932 4986954 An14g01000 Aspergillus niger uncharacterized protein XP_059602255.1 276706 D 5061 CDS An14g01010 4986955 complement(join(278871..279330,279383..279549,279741..279853,280466..280533,280631..280644)) I 1 NT_166529.1 Complex: the YGL076c gene product from S. cerevisiae is part of cytoplasmic ribosomal large subunit.; Remark: alternate gene-names are RPL6A, YL8A,YGL076c.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L7 - Saccharomyces cerevisiae; cytoplasm; See PMID 1544921; See PMID 1549461; 60S ribosomal uL30 domain-containing protein 280644 4986955 An14g01010 Aspergillus niger 60S ribosomal uL30 domain-containing protein XP_059602256.1 278871 R 5061 CDS An14g01020 4986956 join(280817..281071,281108..281292,281370..281678,281722..281740) I 1 NT_166529.1 Function: the ELL complex in human is involved in the derepression of gene expression.; Similarity: the human gene shows also sequence similarity to the S. cerevisiae SNF8.; Title: strong similarity to derepression ELL complex subunit EAP30 - Homo sapiens; See PMID 10419521; uncharacterized protein 281740 4986956 An14g01020 Aspergillus niger uncharacterized protein XP_059602257.1 280817 D 5061 CDS An14g01030 84592906 complement(282338..>283855) I 1 NT_166529.1 Function: the human eIF3-SU8 binds to the 40S ribosome and promotes the binding of methionyl-tRNAi and mRNA.; Remark: N-terminally truncated protein due to the end of contig.; Title: strong similarity to translation initiation factor eIF-3 subunit - Homo sapiens [truncated ORF]; cytoplasm; See PMID 8995409; uncharacterized protein 283855 84592906 An14g01030 Aspergillus niger uncharacterized protein XP_059602258.1 282338 R 5061 CDS An14g01040 4986957 complement(join(<283956..284357,284447..284786)) I 1 NT_166529.1 Function: Nip1p has a primary role in translation initiation. Nip1p is a subunit of eukaryotic initiation factor 3 required for efficient translation initiation.; Localization: mainly cytoplasmic.; Remark: C-terminus truncated due to end of contig.; Title: similarity to nuclear transport protein Nip1 - Saccharomyces cerevisiae [truncated ORF]; See PMID 9722586; See PMID 1332047; uncharacterized protein 284786 4986957 An14g01040 Aspergillus niger uncharacterized protein XP_001400732.3 283956 R 5061 CDS An14g01050 4986959 complement(join(286066..286829,286881..287239,287300..287419,287477..287736,287796..287955,288020..288219,288276..288547,288617..289169)) I 1 NT_166529.1 Catalytic activity: ATP + a Protein = ADP + a Phosphoprotein; Function: Yak1p functions as a negative regulator of the cell cycle in S. cerevisiae.; Remark: Yak1 acts downstream of the cAMP-dependent protein kinase in yeast.; Remark: the database proteins are all shorter in length.; Title: similarity to serine/threonine protein kinase Yak1 - Saccharomyces cerevisiae; See PMID 8150276; See PMID 10816418; See PMID 2558053; uncharacterized protein 289169 4986959 An14g01050 Aspergillus niger uncharacterized protein XP_001400734.1 286066 R 5061 CDS An14g01060 4986960 join(291399..291635,291691..291764,291822..295182) I 1 NT_166529.1 Complex: protein may interact with TFIIH, which is involved in transcription-coupled repair.; Function: putative helicase, DNA repair and recombination protein.; Similarity: also similarity to human DNA repair helicase ERCC6.; Title: strong similarity to DNA repair and recombination protein Rad26 - Saccharomyces cerevisiae; nucleus; See PMID 9566886; See PMID 9880486; See PMID 10666451; uncharacterized protein 295182 4986960 An14g01060 Aspergillus niger uncharacterized protein XP_059604586.1 291399 D 5061 CDS An14g01068 4986961 join(297289..297697,297764..297855) I 1 NT_166529.1 Title: strong similarity to EST an_2307 -Aspergillus niger; uncharacterized protein 297855 4986961 An14g01068 Aspergillus niger uncharacterized protein XP_001400736.1 297289 D 5061 CDS An14g01070 4986962 join(299188..299293,299379..299984,300034..300170) I 1 NT_166529.1 Remark: similarity corresponds only to multiple A and T-repeats.; Title: strong similarity to hypothetical protein EAA61306.1 - Aspergillus nidulans; uncharacterized protein 300170 4986962 An14g01070 Aspergillus niger uncharacterized protein XP_001400737.1 299188 D 5061 CDS An14g01080 4986963 complement(join(302114..302278,302350..303006,303062..303253)) I 1 NT_166529.1 Remark: similarities correspond to different short domains.; hypothetical protein 303253 4986963 An14g01080 Aspergillus niger hypothetical protein XP_001400738.3 302114 R 5061 CDS An14g01110 4986965 complement(join(304705..304865,304918..305184,305241..305901,305962..306411)) I 1 NT_166529.1 Function: YlALK1 functions to assimilate n-decane and longer molecules in Yarrowia lipolytica.; Induction: the expression of the P450 gene YlALK1 was induced by n-tetradecane and repressed by glycerol in Yarrowia lipolytica.; Remark: disruption of Yarrowia lipolytica gene ALK1 results in decreased n-decane assimilation.; Title: strong similarity to alkane-inducible cytochrome P450 gene ALK1 - Yarrowia lipolytica; See PMID 3892551; See PMID 9848230; See PMID 10953079; uncharacterized protein 306411 4986965 An14g01110 Aspergillus niger uncharacterized protein XP_001400739.1 304705 R 5061 CDS An14g01120 4986966 complement(join(307156..308625,308680..308838)) I 1 NT_166529.1 Similarity: the human gene has sequence homology with lysosomal prolylcarboxypeptidase.; Title: strong similarity to thymus specific serine peptidase TSSP - Homo sapiens; See PMID 10527559; See PMID 10630289; uncharacterized protein 308838 4986966 An14g01120 Aspergillus niger uncharacterized protein XP_001400740.3 307156 R 5061 CDS An14g01130 4986967 join(311672..311927,311970..312077,312126..312247,312294..312363,312410..312485,312531..312582,312630..312841,312890..313111,313174..313420,313478..313618,313682..313738,313867..313905) I 1 NT_166529.1 Expression: expression of rhamnogalacturonan degrading enzymes by A. acculeatus is regulated at the level of transcription and is subjected to carbon catabolite repression by glucose.; Function: the enzyme is found to be a rhamnogalacturonan alpha-L-rhamnopyranosyl-(1-->4)-alpha-D-galactopyranosylur onide lyase.; Remark: rhamnogalacturonan is a pectic polysaccharide.; Title: strong similarity to rhamnogalacturonase B precursor rhgB - Aspergillus aculeatus; See PMID 7576553; See PMID 7592973; See PMID 7961884; See PMID 8587995; uncharacterized protein 313905 4986967 An14g01130 Aspergillus niger uncharacterized protein XP_059604587.1 311672 D 5061 CDS An14g01140 4986968 complement(join(<314011..315374,315500..315736)) I 1 NT_166529.1 Catalytic activity: guanine + H2O = xanthine + NH3.; Remark: a putative sequencing error results in an frameshift.; Similarity: shows also similarity to chlorohydrolases from different bacteria.; Title: strong similarity to guanine deaminase Gda -Mus musculus [putative frameshift]; putative frameshift; See PMID 6098039; See PMID 8226898; See PMID 10075721; uncharacterized protein 315736 4986968 An14g01140 Aspergillus niger uncharacterized protein XP_059604588.1 314011 R 5061 CDS An14g01150 4986969 complement(join(316332..316387,316439..319565)) I 1 NT_166529.1 Catalytic activity: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2.; Remark: protein is a component, with EC 2. 1. 2. 10,of the glycine cleavage system, previously known as glycine synthase.; Similarity: the protein shows also similarities to aminomethyltransferases from different organisms.; Title: strong similarity to glycine dehydrogenase component P - Pisum sativum; localisation:mitochondrion; See PMID 8206222; See PMID 9479445; uncharacterized protein 319565 4986969 An14g01150 Aspergillus niger uncharacterized protein XP_001400743.1 316332 R 5061 CDS An14g01160 4986970 complement(join(320635..320758,320814..321275,321332..321549,321596..321741,321788..321835,321894..321963,322025..322199,322317..322534)) I 1 NT_166529.1 Expression: DAL5 is a constitutively expressed allantoin system gene whose product is required for allantoate transport in yeast.; Remark: dal5 mutants of S. cerevisiae lack allantoate transport; these mutant strains also exhibit a 60% loss of allantoin transport capability.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 3549700; See PMID 2651902; See PMID 3275614; uncharacterized protein 322534 4986970 An14g01160 Aspergillus niger uncharacterized protein XP_059604589.1 320635 R 5061 CDS An14g01170 4986971 complement(join(324387..324826,324916..325741)) I 1 NT_166529.1 Title: similarity to hypothetical protein B7F18.110 - Neurospora crassa; uncharacterized protein 325741 4986971 An14g01170 Aspergillus niger uncharacterized protein XP_059604590.1 324387 R 5061 CDS An14g01180 4986972 join(326029..326718,326780..328516,328585..328923) I 1 NT_166529.1 Remark: similarity corresponds to a distinct region.; Title: similarity to hypothetical protein encoded by An02g08790 - Aspergillus niger; uncharacterized protein 328923 4986972 An14g01180 Aspergillus niger uncharacterized protein XP_001400746.1 326029 D 5061 CDS An14g01190 4986973 329777..330667 I 1 NT_166529.1 Catalytic activity: L-arginine + H(2)O = L-ornithine + urea.; Regulation: arginase activity is regulated by various small molecules, including the product L-ornithine.; Remark: enzyme is a hexamer in B. caldovelox.; Title: similarity to arginase - Bacillus caldovelox; See PMID 8647285; See PMID 2029528; uncharacterized protein 330667 4986973 An14g01190 Aspergillus niger uncharacterized protein XP_001400747.1 329777 D 5061 CDS An14g01200 84592907 complement(join(331024..331527,331594..331771,331827..331982,332053..332262,332310..332442,332512..333215,333270..333352,333440..333511)) I 1 NT_166529.1 Function: nirA of A. nidulans is a zinc finger transcription factor mediating nitrate induction of genes involved in nitrate assimilation (nitrate reductase,nitrite reductases and a nitrate permease, niaD, niiA and crnA, respectively).; Remark: the nitrate assimilation genes are induced by nitrate and repressed by ammonium at the transcriptional level.; Title: strong similarity to nitrate assimilation regulatory protein nirA - Aspergillus nidulans; nucleus; See PMID 347305; See PMID 1990284; uncharacterized protein 333511 84592907 An14g01200 Aspergillus niger uncharacterized protein XP_059604591.1 331024 R 5061 CDS An14g01210 4986975 complement(join(334964..335228,335286..335529,335582..336389)) I 1 NT_166529.1 Function: protein oxidatively degrade glycated low molecular weight amines and amino acids under formation of hydrogen peroxide and glucosone in Aspergillus.; Title: strong similarity to fructosyl amine oxygen oxidoreductase - Aspergillus fumigatus; See PMID 9013588; See PMID 9139700; uncharacterized protein 336389 4986975 An14g01210 Aspergillus niger uncharacterized protein XP_001400749.1 334964 R 5061 CDS An14g01225 84592908 complement(join(<337479..337574,337593..337957,338008..338321)) I 1 NT_166529.1 Function: SRPK2 phosphorylates the SR family of splicing factors in human.; Function: play an important role in regulating both the spliceosome assembly and their intranuclear distribution; Remark: ORF is truncated due to the border of contig.; Title: similarity to serine kinase SRPK2 - Homo sapiens [truncated ORF]; See PMID 10049757; See PMID 9472028; uncharacterized protein 338321 84592908 An14g01225 Aspergillus niger uncharacterized protein XP_059602259.1 337479 R 5061 CDS An14g01235 4986977 complement(join(339430..340379,340420..340615)) I 1 NT_166529.1 Title: strong similarity to essential gene #5905 from patent WO200277183-A2 - Bacteroides fragilis; uncharacterized protein 340615 4986977 An14g01235 Aspergillus niger uncharacterized protein XP_059602260.1 339430 R 5061 CDS An14g01245 4986978 join(340885..341133,341184..342386) I 1 NT_166529.1 Function: ord1 of A. flavus encodes a cytochrome P-450-type monooxygenase involved in conversion of O-methylsterigmatocystin to aflatoxin.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Title: strong similarity to O-methylsterigmatocystin oxidoreductase ord1 - Aspergillus flavus; See PMID 9143099; uncharacterized protein 342386 4986978 An14g01245 Aspergillus niger uncharacterized protein XP_001400752.3 340885 D 5061 CDS An14g01253 4986979 complement(join(342626..343180,343239..343330,343380..343490,343550..343886)) I 1 NT_166529.1 Remark: mutants defective in esterase RAG-1 lose to grow on simple triglycerides such as triacetin.; Title: similarity to esterase est - Acinetobacter calcoaceticus; uncharacterized protein 343886 4986979 An14g01253 Aspergillus niger uncharacterized protein XP_001400753.1 342626 R 5061 CDS An14g01255 4986980 join(344332..344531,344608..345726,345783..346175,346235..346483,346640..346964) I 1 NT_166529.1 Function: CTF1 beta from F. solani is involved in the constitutive expression of cut2 that causes production of low levels of cutin monomers that strongly induce cut1 using CTF1 alpha as the transcription factor.; Function: CTF1beta from F. solani regulates the gene induction by cutin monomers.; Title: similarity to cutinase transcription factor beta CTF1b - Fusarium solani; nucleus; See PMID 11756444; See PMID 8132657; uncharacterized protein 346964 4986980 An14g01255 Aspergillus niger uncharacterized protein XP_001400754.3 344332 D 5061 CDS An14g01260 4986981 join(347623..347794,347850..348251,348310..348644,348728..349068,349162..349309,349364..349468,349640..349720) I 1 NT_166529.1 Function: hapE of P. fluorescens catalyses the NADPH-dependent oxidation of 4-hydroxyacetophenone to 4-hydroxyphenyl acetate.; Similarity: the predicted ORF shows moderate similarity to several hypothetical and known monooxygenases with different specificity.; Title: similarity to 4-Hydroxyacetophenone monooxygenase hapE - Pseudomonas fluorescens; See PMID 11322873; uncharacterized protein 349720 4986981 An14g01260 Aspergillus niger uncharacterized protein XP_059602261.1 347623 D 5061 CDS An14g01270 4986982 join(350571..350943,351017..351121,351184..351422,351500..351727,351787..351900) I 1 NT_166529.1 Catalytic activity: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH.; Function: FabG of S. melioti is the 3-oxoacyl-acyl carrier protein reductase that catalyzes the first reduction step in each cycle of fatty acid elongation.; Similarity: the predicted ORF shows similarity also to other oxidoreductases with different substrate specificity.; Title: similarity to 3-oxoacyl-(acyl carrier protein) reductase fabG - Sinorhizobium meliloti; See PMID 11277432; uncharacterized protein 351900 4986982 An14g01270 Aspergillus niger uncharacterized protein XP_001400756.1 350571 D 5061 CDS An14g01280 4986983 complement(352896..353804) I 1 NT_166529.1 Similarity: the predicted protein shows similarity to many hypothetical short-chain dehydrogenases of various substrate specificities.; Title: similarity to hypothetical oxidoreductase SMa2343 - Sinorhizobium meliloti; uncharacterized protein 353804 4986983 An14g01280 Aspergillus niger uncharacterized protein XP_001400757.1 352896 R 5061 CDS An14g01300 84592909 complement(join(355698..355928,356064..356162)) I 1 NT_166529.1 hypothetical protein 356162 84592909 An14g01300 Aspergillus niger hypothetical protein XP_059602262.1 355698 R 5061 CDS An14g01310 84592910 join(356452..356556,356646..356740,357002..357153,357332..357481,357573..357693,357796..357937) I 1 NT_166529.1 Title: weak similarity to hypothetical protein PA3829 - Pseudomonas aeruginosa; uncharacterized protein 357937 84592910 An14g01310 Aspergillus niger uncharacterized protein XP_059602263.1 356452 D 5061 CDS An14g01330 4986988 complement(join(360193..360921,360984..361225,361284..361424,361477..361715,361770..361975)) I 1 NT_166529.1 Title: strong similarity to hypothetical protein encoded by An02g11890 - Aspergillus niger; uncharacterized protein 361975 4986988 An14g01330 Aspergillus niger uncharacterized protein XP_001400760.1 360193 R 5061 CDS An14g01340 4986989 complement(join(362518..362558,362743..363593,363644..363883,363943..364145)) I 1 NT_166529.1 Catalytic activity: 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate = cis,cis-butadiene-1,2,4-tricarboxylate.; Function: PcaB confers the ability to use 4-hydroxybenzoate or protocatechuate as the only carbon source. Hydroxyaromatics catabolism by pcaB serves both nutritional and detoxifying purposes.; Title: strong similarity to 3-carboxy-cis,cis-muconate cycloisomerase pcaB - Bradyrhizobium japonicum; See PMID 9582432; uncharacterized protein 364145 4986989 An14g01340 Aspergillus niger uncharacterized protein XP_001400761.3 362518 R 5061 CDS An14g01350 4986990 join(364569..365430,365488..365878,365939..366224) I 1 NT_166529.1 Function: the function of AmMST1 of A. muscaria as monosaccharide transporter was confirmed by heterologous expression of the cDNA in a S. pombe mutant lacking a monosaccharide uptake system.; Similarity: the predicted protein shows similarity to many hypothetical and known sugar transposters with different specificity.; Title: strong similarity to monosaccharide transporter AmMst-1 - Amanita muscaria; plasma membrane; See PMID 9487692; uncharacterized protein 366224 4986990 An14g01350 Aspergillus niger uncharacterized protein XP_001400762.1 364569 D 5061 CDS An14g01360 84592911 join(367206..367262,367501..368129,368183..369182) I 1 NT_166529.1 Function: deletion and fusion constructs and in vitro mutagenesis indicated that the Zn(II)2Cys6 cluster and the C-terminal end of A. nidulans FacB are required for function.; Function: deletion of the gene confirmed that it is required for growth on acetate as a sole carbon source.; Function: facB of A. nidulans encodes a N-terminal GAL4-like Zn(II)2Cys6 transcriptional activator.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; See PMID 10483720; See PMID 9197408; See PMID 9524126; uncharacterized protein 369182 84592911 An14g01360 Aspergillus niger uncharacterized protein XP_059602264.1 367206 D 5061 CDS An14g01370 4986992 370756..371232 I 1 NT_166529.1 hypothetical protein 371232 4986992 An14g01370 Aspergillus niger hypothetical protein XP_001400764.1 370756 D 5061 CDS An14g01380 4986993 complement(join(371636..372625,372692..372806,372987..373189)) I 1 NT_166529.1 Similarity: the predicted protein shows weak similarity also to a synthetic patented subtilisin.; Title: weak similarity to intracellular alkaline serine proteinase - Thermoactinomyces sp.; See PMID 9058969; uncharacterized protein 373189 4986993 An14g01380 Aspergillus niger uncharacterized protein XP_059602265.1 371636 R 5061 CDS An14g01390 4986994 complement(373627..375681) I 1 NT_166529.1 Title: strong similarity to hypothetical protein AAO75370.1 - Bacteroides thetaiotaomicron; uncharacterized protein 375681 4986994 An14g01390 Aspergillus niger uncharacterized protein XP_001400766.1 373627 R 5061 CDS An14g01400 84592912 join(376070..376206,376305..376384,376592..376709,376919..376996,377080..377245) I 1 NT_166529.1 Title: questionable ORF; uncharacterized protein 377245 84592912 An14g01400 Aspergillus niger uncharacterized protein XP_059602266.1 376070 D 5061 CDS An14g01410 4986996 377460..378317 I 1 NT_166529.1 Title: weak similarity to hypothetical galactose-1-phosphate uridylyltransferase galT -Pasteurella multocida; uncharacterized protein 378317 4986996 An14g01410 Aspergillus niger uncharacterized protein XP_001400768.1 377460 D 5061 CDS An14g01420 4986997 join(379753..379960,380013..380175,380224..381285,381339..381648) I 1 NT_166529.1 Title: strong similarity to hypothetical membrane protein YMR221c - Saccharomyces cerevisiae; uncharacterized protein 381648 4986997 An14g01420 Aspergillus niger uncharacterized protein XP_001400769.1 379753 D 5061 CDS An14g01430 4986998 join(382473..382719,382780..383217,383273..>383985) I 1 NT_166529.1 Remark: C-terminally truncated ORF due to contig border.; Similarity: the similarity to PA2682 of P. aeruginosa involves only the C-terminal half of the two proteins.; Title: strong similarity to hypothetical conserved protein PA2682 - Pseudomonas aeruginosa [truncated ORF]; uncharacterized protein 383985 4986998 An14g01430 Aspergillus niger uncharacterized protein XP_001400770.3 382473 D 5061 CDS An14g01440 4986999 complement(join(384304..384417,384481..384892,384952..385424,385478..385879)) I 1 NT_166529.1 Catalytic activity: SSADH of R. norvegicus catalyzes the reaction: Succinate semialdehyde + NAD+ + H2O = Succinate + NADH.; Pathway: SSADH of R. norvegicus and other species is involved in the butanoate metabolic pathway, and in the glutamate catabolic pathway.; Phenotype: mutations in the SSADH gene in humans cause a neurological syndrome, due to a defect of catabolism of the neurotransmitter GABA.; Similarity: the predicted ORF shows strong similarity to different dehydrogenases, in particular to succinate-semialdehyde dehydrogenase; most of them are hypothetical and belong to different bacterial species, the first described one being the R. norvegicus enzyme.; Title: strong similarity to succinate-semialdehyde dehydrogenase SSADH - Rattus norvegicus; See PMID 7814412; uncharacterized protein 385879 4986999 An14g01440 Aspergillus niger uncharacterized protein XP_001400771.1 384304 R 5061 CDS An14g01450 4987000 complement(join(386128..386418,386496..386722,386780..387005)) I 1 NT_166529.1 Similarity: SPAC13C5. 04 of S. pombe and the predicted ORF show some similarity to tdnT of Pseudomonas putida, a hypothetical ORF of the aromatic amine catabolic pathway gene cluster, containing domains that are conserved among amidotransferases.; Title: strong similarity to hypothetical protein SPAC13C5.04 - Schizosaccharomyces pombe; See PMID 8990291; uncharacterized protein 387005 4987000 An14g01450 Aspergillus niger uncharacterized protein XP_001400772.1 386128 R 5061 CDS An14g01460 4987001 join(387645..388059,388121..388383,388435..388487,388538..389222) I 1 NT_166529.1 Catalytic activity: ATP + L-glutamate + NH3 <-> ADP + phosphate + L-glutamine.; Remark: glutamate--ammonia ligase is also known as glutamine synthetase.; Remark: manual closest BLASTP homologue: PIR:JC1301.; Title: strong similarity to glutamate--ammonia ligase III glnT - Rhizobium leguminosarum; See PMID 1356885; uncharacterized protein 389222 4987001 An14g01460 Aspergillus niger uncharacterized protein XP_001400773.3 387645 D 5061 CDS An14g01470 4987002 join(389538..389708,389783..389899,389959..390502,390574..390967,391028..391076) I 1 NT_166529.1 Title: strong similarity to hypothetical protein SPAC1039.06 - Schizosaccharomyces pombe; uncharacterized protein 391076 4987002 An14g01470 Aspergillus niger uncharacterized protein XP_001400774.3 389538 D 5061 CDS An14g01480 4987003 join(391711..391760,391874..392414,392507..392767) I 1 NT_166529.1 Function: levodione reductase in C. aquaticum catalyzes regio- and stereoselective reduction of levodione ((6R)-2,2,6-Trimethyl-1,4-cyclohexanedione) to (4R,6R)-4-hydroxy-2,2, 6-trimethylcyclohexanone (actinol).; Similarity: the predicted ORF shows similarity to many short-chain dehydrogenases with different substrate specificity.; Title: strong similarity to levodione reductase lvr - Corynebacterium aquaticum; See PMID 10508066; See PMID 11388460; uncharacterized protein 392767 4987003 An14g01480 Aspergillus niger uncharacterized protein XP_059604592.1 391711 D 5061 CDS An14g01490 4987004 complement(join(392827..393654,393700..394512)) I 1 NT_166529.1 Remark: UME6 of S. cerevisiae is also called CAR80,NIM2, RIM16 or YDR207C.; Similarity: the similarity to UME6 of S. cerevisiae and other known or putative transcription factors is due to the presence of a fungal Zn(2) - Cys(6) binuclear cluster domain in the N-terminal region of the predicted protein; no other homology is present.; Title: weak similarity to transcription factor Ume6 - Saccharomyces cerevisiae; See PMID 1579492; uncharacterized protein 394512 4987004 An14g01490 Aspergillus niger uncharacterized protein XP_001400776.1 392827 R 5061 CDS An14g01500 4987005 complement(join(394951..396126,396196..396387)) I 1 NT_166529.1 Title: strong similarity to hypothetical protein SPAC1039.06 - Schizosaccharomyces pombe; uncharacterized protein 396387 4987005 An14g01500 Aspergillus niger uncharacterized protein XP_001400777.1 394951 R 5061 CDS An14g01510 84592913 complement(join(397469..398807,398858..399909)) I 1 NT_166529.1 Similarity: the length of the predicted protein does not correspond to the one of N. crassa B24P7. 50.; Title: similarity to hypothetical protein B24P7.50 -Neurospora crassa; uncharacterized protein 399909 84592913 An14g01510 Aspergillus niger uncharacterized protein XP_059604593.1 397469 R 5061 CDS An14g01520 84592914 400144..401037 I 1 NT_166529.1 Title: similarity to hypothetical protein encoded by An12g09920 - Aspergillus niger; uncharacterized protein 401037 84592914 An14g01520 Aspergillus niger uncharacterized protein XP_059604594.1 400144 D 5061 CDS An14g01530 4987008 complement(join(401109..401155,401221..401662,401712..403532,403590..403811)) I 1 NT_166529.1 Function: in B. polymyxa isp is involved in the generation of multiple beta-amylases and an alpha-amylase from a large amylase precursor.; Similarity: the C- terminal part of the predicted protein shows similarity to several other serine proteases like subtilisin.; Similarity: the similarity to isp of B. polymyxa is limited to the C-terminal third of the predicted protein.; Title: similarity to intracellular serine proteinase isp - Bacillus polymyxa; See PMID 1834632; uncharacterized protein 403811 4987008 An14g01530 Aspergillus niger uncharacterized protein XP_059604595.1 401109 R 5061 CDS An14g01540 4987009 complement(<404253..405672) I 1 NT_166529.1 Function: in spite of this similarity, TAT1 protein exhibit Na+-independent and low-affinity transport of aromatic amino acids such as tryptophan, tyrosine, and phenylalanine, and this activity is not coupled with H+ transport, rather it behaves as an electroneutral facilitated diffusion.; Remark: a putative sequencing error results in an frameshift.; Similarity: the predicted protein and TAT1 of R. norvegicus show similarity to H+/monocarboxylate transporters.; Similarity: the predicted protein shows similarity to transporters with different specificity, thus the substrate is only hypothetical.; Title: similarity to aromatic amino acid transporter TAT1 - Rattus norvegicus [putative frameshift]; plasma membrane; putative frameshift; See PMID 11278508; uncharacterized protein 405672 4987009 An14g01540 Aspergillus niger uncharacterized protein XP_059604596.1 404253 R 5061 CDS An14g01550 4987010 complement(join(405999..406034,406092..407114,407184..407375)) I 1 NT_166529.1 Catalytic activity: acid phosphatases also catalyze transphosphorylations.; Catalytic activity: acid phosphatases catalyze the hydrolysis of an ortophosphoric monoester to alcohol + ortophosphate, with wide specificity.; Title: strong similarity to acid phosphatase AFPhoA - Aspergillus ficuum; extracellular/secretion proteins; See PMID 7945393; uncharacterized protein 407375 4987010 An14g01550 Aspergillus niger uncharacterized protein XP_001400782.1 405999 R 5061 CDS An14g01560 4987011 complement(join(408264..409313,409364..409504,409562..409714)) I 1 NT_166529.1 Complex: zuotin of S. cerevisiae is a component of the RAC (ribosome-associated complex), that is bound to the ribosome via the zuotin subunit.; Function: RAC stimulates the translocation of a ribosome-bound mitochondrial precursor protein into mitochondria, providing evidence for its chaperone-like effect on nascent chains.; Similarity: zuotin of S. cerevisiae and the predicted protein show strong similarity and functional homology to DnaJ/Hsp40, a molecular chaperone that,together with Hsp70, is involved in folding and translocation in various subcellular compartments of the newly synthesized proteins.; Title: strong similarity to zuotin Zuo1 -Saccharomyces cerevisiae; cytoplasm; See PMID 9707440; See PMID 10660055; See PMID 11054575; See PMID 11274393; See PMID 1396572; uncharacterized protein 409714 4987011 An14g01560 Aspergillus niger uncharacterized protein XP_001400783.1 408264 R 5061 CDS An14g01570 4987012 join(410170..410245,410305..410481,410547..410641) I 1 NT_166529.1 Similarity: homologs of the present and the two previous ORFs are present in N. crassa in the same order.; Title: strong similarity to hypothetical protein B24P7.260 - Neurospora crassa; uncharacterized protein 410641 4987012 An14g01570 Aspergillus niger uncharacterized protein XP_001400784.1 410170 D 5061 CDS An14g01580 4987013 complement(join(410903..411919,411973..412113)) I 1 NT_166529.1 Complex: SPCC550. 02c of S. pombe, also called cwf5p, coimmunoprecipitates with a 40S protein complex involved in pre-mRNA splicing.; Similarity: homologs of the previous, present and next ORF are present in N. crassa in the same order.; Similarity: the predicted protein is very similar to the hypotetical protein B24P7. 250 of N. crassa.; Title: strong similarity to hypothetical RNA binding protein SPCC550.02c - Schizosaccharomyces pombe; See PMID 10409726; uncharacterized protein 412113 4987013 An14g01580 Aspergillus niger uncharacterized protein XP_001400785.1 410903 R 5061 CDS An14g01590 4987014 join(412994..413197,413265..413299,413366..414260) I 1 NT_166529.1 Catalytic activity: ERG6 of C. albicans converts S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol to S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.; Complex: ERG6 of C. albicans is a homotetramer.; Pathway: ERG6 of C. albicans carries out methylation of zymosterol as part of the ergosterol biosynthesis pathway.; Similarity: homologs of the present and the two next ORFs are present in N. crassa in the same order.; Title: strong similarity to sterol transmethylase ERG6 - Candida albicans; See PMID 9593144; uncharacterized protein 414260 4987014 An14g01590 Aspergillus niger uncharacterized protein XP_001400786.1 412994 D 5061 CDS An14g01600 4987015 complement(join(414729..414875,414986..415176,415281..415631,415689..415909,415957..416031,416081..416402,416542..416773)) I 1 NT_166529.1 Induction: in A. parasiticus expression of the hxtA gene, encoding a hexose transporter protein, was found to be concurrent with the aflatoxin pathway cluster genes, in aflatoxin-conducive medium.; Title: strong similarity to hexose transporter hxtA - Aspergillus parasiticus; See PMID 10978525; uncharacterized protein 416773 4987015 An14g01600 Aspergillus niger uncharacterized protein XP_059604597.1 414729 R 5061 CDS An14g01610 84592915 complement(join(417217..418060,418111..418607)) I 1 NT_166529.1 Title: similarity to hypothetical protein BAC75132.1 - Streptomyces avermitilis; uncharacterized protein 418607 84592915 An14g01610 Aspergillus niger uncharacterized protein XP_059604598.1 417217 R 5061 CDS An14g01620 4987017 join(419185..419315,419365..419484,419541..419680,419762..419869,419923..420291,420340..420431,420495..420528,420588..421033) I 1 NT_166529.1 Title: weak similarity to heparanase - Homo sapiens; See PMID 10764835; uncharacterized protein 421033 4987017 An14g01620 Aspergillus niger uncharacterized protein XP_001400789.1 419185 D 5061 CDS An14g01630 4987018 join(421548..421656,421714..422790,422840..422991) I 1 NT_166529.1 Phenotype: overexpression of SNG1 in S. cerevisiae confers hyper-resistance to the mutagen N-methyl-N'nitro-N-nitrosoguanidine (MNNG), whereas null mutants are viable and exhibit only slight sensitivity to MNNG, indicating that SNG1 does not encode a protein involved in a major detoxification step of this mutagen.; Similarity: the predicted protein is about 100 residues shorter than SNG1 of S. cerevisiae.; Title: similarity to nitrosoguanidine resistance factor Sng1 - Saccharomyces cerevisiae; See PMID 7753113; uncharacterized protein 422991 4987018 An14g01630 Aspergillus niger uncharacterized protein XP_001400790.3 421548 D 5061 CDS An14g01650 84592916 complement(join(425546..425683,425784..425891,426002..426070)) I 1 NT_166529.1 hypothetical protein 426070 84592916 An14g01650 Aspergillus niger hypothetical protein XP_059604599.1 425546 R 5061 CDS An14g01660 4987021 426147..427787 I 1 NT_166529.1 Catalytic activity: in Brevibacterium sp. chnB2 catalyzes the oxidation of cyclohexanone.; Similarity: the predicted ORF shows strong similarity to many known and putative flavin-binding monooxygenases with different substrate specificity.; Similarity: the predicted protein shows very strong similarity to a flavin monooxygenase involved in the degradation of fumonisin in Exophiala spinifera, patented under number WO200105980-A1.; Title: strong similarity to cyclohexanone monooxygenase chnB2 - Brevibacterium sp.; See PMID 10894733; uncharacterized protein 427787 4987021 An14g01660 Aspergillus niger uncharacterized protein XP_001400792.1 426147 D 5061 CDS An14g01670 4987022 join(430309..430522,430574..430772,430896..431346,431401..431895,431946..432167) I 1 NT_166529.1 Function: PRF from N. haematococca binds at a promoter-distal element which provided transcriptional activation.; Similarity: the similarity to other known or putative transcription factors is due to the presence of a fungal Zn(2) - Cys(6) binuclear cluster domain in the N-terminal region of the predicted protein; no other homology is present.; Title: similarity to binuclear zinc transcription factor PRF - Nectria haematococca; See PMID 8850087; See PMID 856968; uncharacterized protein 432167 4987022 An14g01670 Aspergillus niger uncharacterized protein XP_059604600.1 430309 D 5061 CDS An14g01680 4987023 join(432589..432734,432783..434073) I 1 NT_166529.1 Function: MCT3 of R. norvegicus is necessary for efflux of lactic acid from several cell types, but mostly from muscle fibers.; Similarity: the predicted protein shows similarity to many hypothetical membrane proteins and particularly to monocarboxilate transporters.; Title: similarity to monocarboxylate transporter MCT3 - Rattus norvegicus; See PMID 9632638; uncharacterized protein 434073 4987023 An14g01680 Aspergillus niger uncharacterized protein XP_001400794.1 432589 D 5061 CDS An14g01685 4987024 complement(434267..434734) I 1 NT_166529.1 hypothetical protein 434734 4987024 An14g01685 Aspergillus niger hypothetical protein XP_001400795.1 434267 R 5061 CDS An14g01690 4987025 complement(435711..436640) I 1 NT_166529.1 hypothetical protein 436640 4987025 An14g01690 Aspergillus niger hypothetical protein XP_001400796.1 435711 R 5061 CDS An14g01700 4987026 complement(join(<437012..437691,437734..438202,438245..438765)) I 1 NT_166529.1 Function: PHO84 of S. cerevisiae catalyzes a proton-coupled phosphate transport at acidic pH.; Function: in S. cerevisiae another phosphate transport appears to be due to a constitutive low-affinity H+-phosphate symporter and a high-affinity Na+-phosphate co-transporter.; Induction: PHO84 of S. cerevisiae is derepressed in low phosphate.; Remark: a putative sequencing error results in an frameshift.; Title: strong similarity to high-affinity inorganic phosphate/H+ symporter Pho84 - Saccharomyces cerevisiae [putative frameshift]; plasma membrane; putative frameshift; See PMID 2038328; See PMID 8552045; See PMID 8720066; See PMID 1398064; See PMID 1620108; uncharacterized protein 438765 4987026 An14g01700 Aspergillus niger uncharacterized protein XP_059604601.1 437012 R 5061 CDS An14g01710 4987027 complement(join(439525..439598,439635..440226,440272..441104,441151..441406)) I 1 NT_166529.1 Function: NapA of E. hirae, together with an ATP-driven sodium pump, contributes to Na+ extrusion when the bacterium grows in a sodium-rich environment.; Similarity: the predicted protein shows moderate similarity to several putative Na+/H+ antiporters; NapA of E. hirae is only the better described one.; Title: similarity to Na+/H+-exchanging protein NapA - Enterococcus hirae; plasma membrane; See PMID 8253756; See PMID 1312090; See PMID 1325937; uncharacterized protein 441406 4987027 An14g01710 Aspergillus niger uncharacterized protein XP_059604602.1 439525 R 5061 CDS An14g01720 84592917 443084..443269 I 1 NT_166529.1 Similarity: shows homology to fibroin repeat domains.; hypothetical protein 443269 84592917 An14g01720 Aspergillus niger hypothetical protein XP_059604603.1 443084 D 5061 CDS An14g01730 4987029 complement(join(443766..446874,446934..448759,448809..448830,448870..449475,449557..449585)) I 1 NT_166529.1 Function: DEAD-box helicases are involved in various aspects of RNA transcription, processing and degradation.; Function: DEAD-box helicases require ATP for the unwinding of nucleic acids.; Similarity: belongs to the family of DEAD/DEAH box helicases.; Title: strong similarity to hypothetical DEAD/DEAH-box RNA helicase SPAC694.02 - Schizosaccharomyces pombe; uncharacterized protein 449585 4987029 An14g01730 Aspergillus niger uncharacterized protein XP_059604604.1 443766 R 5061 CDS An14g01750 84592918 join(451189..451583,451615..451618) I 1 NT_166529.1 Function: OXRD-4 of H. sapiens contains a nitrogenase Mo/Fe metalloprotein domain.; Function: OXRD-4 of H. sapiens is thought to be involved in cell proliferation and inflammation.; Similarity: contains a Rieske [2Fe-2S] iron-sulfur metalloprotein domain.; Similarity: shows homology to a protein of the patent database entry PATENTPROT:AAB19929.; Title: similarity to oxidoreductase OXRD-4 from patent WO200071679-A2 - Homo sapiens; uncharacterized protein 451618 84592918 An14g01750 Aspergillus niger uncharacterized protein XP_059604605.1 451189 D 5061 CDS An14g01760 4987032 join(451715..451733,451826..452571) I 1 NT_166529.1 Remark: EC 2. 3. 1. 41 in eukaryotes normally is part of the multifunctional fatty acid synthase protein.; Remark: it cannot be ruled out that this ORF and the upstream ORF An14g01750 (coding for a putative oxidoreductase) actually constitute a single ORF as predicted by fgenesh.; Title: strong similarity to hypothetical 3-oxoacyl-(acyl-carrier-protein) synthase T32M21.120 -Arabidopsis thaliana; uncharacterized protein 452571 4987032 An14g01760 Aspergillus niger uncharacterized protein XP_059604606.1 451715 D 5061 CDS An14g01770 4987033 complement(join(453128..454175,454275..455412,455464..455599)) I 1 NT_166529.1 Catalytic activity: bgln of C. molischiana catalizes the hydrolysis of terminal non-reducing beta-D-glucose residues with release of beta-D-glucose.; Function: bgln of C. molischiana is mainly involved in the degradation of various aromatic beta-glycosides, eg anthocyanin.; Title: strong similarity to beta-glucosidase bgln -Candida molischiana; cell wall; See PMID 10554245; uncharacterized protein 455599 4987033 An14g01770 Aspergillus niger uncharacterized protein XP_059604607.1 453128 R 5061 CDS An14g01780 84592919 455781..456176 I 1 NT_166529.1 hypothetical protein 456176 84592919 An14g01780 Aspergillus niger hypothetical protein XP_059604608.1 455781 D 5061 CDS An14g01790 84592920 complement(456593..457189) I 1 NT_166529.1 hypothetical protein 457189 84592920 An14g01790 Aspergillus niger hypothetical protein XP_059604609.1 456593 R 5061 CDS An14g01800 4987036 complement(join(457325..458160,458210..458266,458322..458620,458670..458773)) I 1 NT_166529.1 Catalytic activity: melibiose + H2O = galactose + glucose.; Title: strong similarity to alpha-galactosidase -Cyamopsis tetragonoloba; See PMID 2577496; uncharacterized protein 458773 4987036 An14g01800 Aspergillus niger uncharacterized protein XP_001400806.3 457325 R 5061 CDS An14g01810 4987037 join(460487..460846,460998..461325,461361..461533,461578..461724) I 1 NT_166529.1 Function: VanD of E. faecium confers resistance to glycopeptides which would bind to D-alanyl-D-alanine-terminating peptidoglycan precursors,thus preventing their incorporation into the cell wall.; Function: VanD of E. faecium is involved in the biosynthesis of D-alanyl-D-lactate-terminating peptidoglycan precursors.; Similarity: belongs to the family of D-alanine:D-alanine ligases.; Title: similarity to D-alanine:D-lactate ligase vanD - Enterococcus faecium; See PMID 10368136; uncharacterized protein 461724 4987037 An14g01810 Aspergillus niger uncharacterized protein XP_059604610.1 460487 D 5061 CDS An14g01820 4987038 join(463544..463835,463905..464167) I 1 NT_166529.1 Title: strong similarity to hypothetical cell wall protein binB - Aspergillus nidulans; See PMID 10376827; uncharacterized protein 464167 4987038 An14g01820 Aspergillus niger uncharacterized protein XP_001400808.1 463544 D 5061 CDS An14g01830 84592921 complement(join(464831..464883,465130..465374,465479..465547,465612..465677,465767..466055,466263..466440)) I 1 NT_166529.1 hypothetical protein 466440 84592921 An14g01830 Aspergillus niger hypothetical protein XP_059604611.1 464831 R 5061 CDS An14g01840 4987040 466729..467325 I 1 NT_166529.1 Remark: the systematic gene name of TIR3 of S. cerevisiae is YIL011w.; Similarity: TIR3 of S. cerevisiae is related to the temperature-shock induced protein TIP1 of S. cerevisiae.; Title: similarity to hypothetical temperature-shock induced protein Tir3 - Saccharomyces cerevisiae; uncharacterized protein 467325 4987040 An14g01840 Aspergillus niger uncharacterized protein XP_059604612.1 466729 D 5061 CDS An14g01850 4987041 complement(join(467505..467692,467777..468161,468234..468853,468901..469048,469103..469150,469206..469351,469415..469505)) I 1 NT_166529.1 Function: UGA4 of S. cerevisiae mediates the cellular uptake of gamma-aminobutyric acid (GABA).; Induction: UGA4 of S. cerevisiae is induced at the transcriptional level in the presence of GABA, requiring the the inducer-specific factor UGA3 and the pleiotropic factor UGA35/DURL/DAL81.; Repression: UGA4 of S. cerevisiae is repressed by the pleiotropic UGA43/DAL80 repressor.; Title: strong similarity to GABA permease Uga4 -Saccharomyces cerevisiae; plasma membrane; See PMID 8455553; uncharacterized protein 469505 4987041 An14g01850 Aspergillus niger uncharacterized protein XP_001400811.1 467505 R 5061 CDS An14g01860 4987042 complement(join(471139..471348,471401..472052,472119..472175,472230..472360)) I 1 NT_166529.1 Function: RIM2 of S. cerevisiae is essential for mitochondrial DNA metabolism.; Phenotype: inactivation of RIM2 of S. cerevisiae causes the total loss of mitochondrial DNA.; Similarity: belongs to the mitochondrial carrier family (MCF).; Title: strong similarity to mitochondrial carrier protein Rim2 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 7891656; uncharacterized protein 472360 4987042 An14g01860 Aspergillus niger uncharacterized protein XP_001400812.1 471139 R 5061 CDS An14g01870 4987043 complement(join(473325..473645,473697..475174,475289..475415)) I 1 NT_166529.1 Similarity: contains a ATP binding domain reminiscent of AAA family ATPases.; Title: similarity to hypothetical ATPase SCD8A.32c -Streptomyces coelicolor; uncharacterized protein 475415 4987043 An14g01870 Aspergillus niger uncharacterized protein XP_059604613.1 473325 R 5061 CDS An14g01880 84592922 complement(join(476166..477280,477359..477485,477592..477651,477734..477842,478087..479330)) I 1 NT_166529.1 Catalytic activity: phosphatidyl-L-serine = phosphatidylethanolamine + CO2.; Pathway: PSD2 of S. cerevisiae is involved in the biosynthesis of phasphatidylethanolamine.; Title: similarity to phosphatidylserine decarboxylase Psd2 - Saccharomyces cerevisiae; See PMID 7890740; uncharacterized protein 479330 84592922 An14g01880 Aspergillus niger uncharacterized protein XP_059604614.1 476166 R 5061 CDS An14g01890 84592923 complement(join(479833..479921,480283..480460)) I 1 NT_166529.1 Title: questionable ORF; uncharacterized protein 480460 84592923 An14g01890 Aspergillus niger uncharacterized protein XP_059604615.1 479833 R 5061 CDS An14g01900 84592924 481109..>482164 I 1 NT_166529.1 Remark: ORF truncated C-terminally due to end of contig.; Title: weak similarity to hypothetical protein encoded by An09g04780 - Aspergillus niger [truncated ORF]; uncharacterized protein 482164 84592924 An14g01900 Aspergillus niger uncharacterized protein XP_059604616.1 481109 D 5061 CDS An14g01910 4987047 complement(join(<482315..483978,484038..484732,484783..485959,486021..486718,486778..488983,489029..489228,489289..491392,491425..492090,492161..492802,492865..493498)) I 1 NT_166529.1 Function: lovB of A. terreus interacts with lovC in the biosynthesis of the lovastatin precursor dihydromonacolin L.; Pathway: lovB of A. terreus is involved in the lovastatin biosynthesis.; Phenotype: disruption of the lovB gene of A. terreus results in a mutant that is unable to synthesize the nonaketide portion of lovastatin.; Remark: lovastatin is an HMG-CoA reductase ((3S)-hydroxy-3-methylglutaryl-Coenzyme A reductase) inhibitor and thus acting as a cholesterin lowering agent.; Remark: the ORF is C-terminally truncated due to the contig border, however nearly the complete amino acid sequence of lovB of A. terreus is encompassed in the alignment with the ORF.; Title: strong similarity to lovastatin nonaketide synthase lovB - Aspergillus terreus [truncated ORF]; See PMID 11378962; See PMID 10381407; uncharacterized protein 493498 4987047 An14g01910 Aspergillus niger uncharacterized protein XP_059602267.1 482315 R 5061 CDS An14g01920 84592925 join(493735..493860,494073..494096) I 1 NT_166529.1 Remark: unusual intron/exon structure for A. niger and short length (49 amino acids).; Title: questionable ORF; uncharacterized protein 494096 84592925 An14g01920 Aspergillus niger uncharacterized protein XP_059602268.1 493735 D 5061 CDS An14g01930 84592926 join(495055..495061,495212..495324) I 1 NT_166529.1 Remark: unusual intron/exon structure for A. niger and short length (39 amino acids).; Title: questionable ORF; uncharacterized protein 495324 84592926 An14g01930 Aspergillus niger uncharacterized protein XP_059602269.1 495055 D 5061 CDS An14g01940 4987050 join(495907..496030,496125..497074) I 1 NT_166529.1 Function: lovC of A. terreus interacts with lovB in the biosynthesis of the lovastatin precursor dihydromonacolin L.; Remark: lovastatin is an HMG-CoA reductase ((3S)-hydroxy-3-methylglutaryl-Coenzyme A reductase) inhibitor and thus acting as a cholesterin lowering agent.; Similarity: lovC of A. terreus belongs to the Zn-containing oxidoreductases family.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 11386351; See PMID 11412974; uncharacterized protein 497074 4987050 An14g01940 Aspergillus niger uncharacterized protein XP_001400820.1 495907 D 5061 CDS An14g01950 4987051 join(497992..498022,498083..499434) I 1 NT_166529.1 Function: the SPAC18B11. 03c gene product of S. pombe is described as a potential integral membrane protein; however no transmembrane domains have been predicted in the ORF.; Title: similarity to hypothetical protein SPAC18B11.03c - Schizosaccharomyces pombe; uncharacterized protein 499434 4987051 An14g01950 Aspergillus niger uncharacterized protein XP_001400821.1 497992 D 5061 CDS An14g01960 4987052 complement(join(499914..501575,501637..501931,501989..502142,502209..502302)) I 1 NT_166529.1 Function: Axs of D. melanogaster is not required for the segregation of achiasmate heterologs.; Function: Axs of D. melanogaster is required for the meiotic segregation of achiasmate homologs.; Similarity: the alignment between Axs of D. melanogaster and the ORF encompasses only amino acids 146-587 of the ORF (total ORF length: 734 amino acids).; Title: strong similarity to aberrant X segregation Axs - Drosophila melanogaster; See PMID 2503421; See PMID 8349113; uncharacterized protein 502302 4987052 An14g01960 Aspergillus niger uncharacterized protein XP_001400822.1 499914 R 5061 CDS An14g01970 4987053 complement(join(505283..505840,505899..506618)) I 1 NT_166529.1 Function: aflR of A. parasiticus is a transcription factor, activating the transcription of all known aflatoxin biosynthetic genes including itself.; Function: aflR of A. parasiticus is essential for aflatoxin biosynthesis.; Similarity: the ORF shows strong local similarity to aflR genes of different Aspergillus species. The alignments encompass only ca. 100 amino acids, but the zinc finger DNA binding domain is always included.; Title: similarity to aflatoxin biosynthesis regulatory protein aflR - Aspergillus parasiticus; See PMID 10919326; See PMID 10967969; See PMID 11414325; uncharacterized protein 506618 4987053 An14g01970 Aspergillus niger uncharacterized protein XP_001400823.1 505283 R 5061 CDS An14g01980 4987054 506849..507649 I 1 NT_166529.1 Catalytic activity: menG of B. stearothermophilus catalyzes the transfer of a methyl group from 2-heptaprenyl to 1,4-naphthoquinone.; Function: menG of B. stearothermophilus catalyzes the last step of the menaquinone biosynthesis.; Pathway: menG of B. stearothermophilus participates in menaquinone (vitamin K2) biosynthesis.; Remark: menG of B. stearothermophilus belongs to the UBIE family.; Similarity: the ORF is shows similarity (the alignments are all also partial) with methyltransferase of various species.; Similarity: the ORF shows strong similarity to the hypothetical protein SC1E6. 19c of Streptomyces coelicolor.; Similarity: the alignment of the ORF with menG of B. stearothermophilus encompasses only amino acids 39-147 of the ORF (total length: 266 amino acids).; Title: similarity to 2-heptaprenyl-1,4-naphthoquinone methyltransferase menG - Bacillus stearothermophilus; See PMID 9139683; uncharacterized protein 507649 4987054 An14g01980 Aspergillus niger uncharacterized protein XP_001400824.1 506849 D 5061 CDS An14g01990 4987055 complement(join(508505..508656,508738..509407)) I 1 NT_166529.1 Remark: a splice site was detected upstream of the START codon.; Similarity: the ORF overlaps C-terminally with the A. niger EST an_3143, found in EMBLEST:BE758887.; Similarity: the ORF shows unspecific similarity to the protein of gene CG6590 of D. melanogaster and to other proteins, due to it's high proline content.; Title: strong similarity to EST an_3143 -Aspergillus niger; uncharacterized protein 509407 4987055 An14g01990 Aspergillus niger uncharacterized protein XP_001400825.1 508505 R 5061 CDS An14g02000 84592927 complement(join(510353..510435,510529..510862)) I 1 NT_166529.1 hypothetical protein 510862 84592927 An14g02000 Aspergillus niger hypothetical protein XP_059602270.1 510353 R 5061 CDS An14g02010 4987057 complement(join(511157..511220,511275..511461,511513..511767,512551..512680,512733..512810,512861..512932,512988..513095,513148..513166,513285..513753,513900..513903)) I 1 NT_166529.1 Function: the Hum1 protein of S. cerevisiae has been postulated to be involved in cellular adaption to elevated extracellular Ca2+ concentrations and to be a means to attenuate the propagation of Ca2+ signals in this organism.; Function: the Hum1 protein of S. cerevisiae is required for vacuolar Ca2+/H+ exchange.; Function: vacuolar membrane vesicles from hum1 S. cerevisiae mutants lack all Ca2+/H+ antiport activity,demonstrating that the Hum1 protein catalyzes the exchange of Ca2+ for H+ across the yeast vacuolar membrane.; Remark: Hum1 of S. cerevisiae is also called mnr1,vcx1, and YDL128w.; Title: strong similarity to vacuolar H(+)/Ca(2+) exchanger Vcx1 - Saccharomyces cerevisiae; vacuole; See PMID 8668190; See PMID 10219995; See PMID 10371152; uncharacterized protein 513903 4987057 An14g02010 Aspergillus niger uncharacterized protein XP_059602271.1 511157 R 5061 CDS An14g02020 84592928 join(514613..514830,515091..515192,515302..515443,515528..515563,515678..515992) I 1 NT_166529.1 Remark: the ORF has an unusual exon/intron structure for A. niger.; hypothetical protein 515992 84592928 An14g02020 Aspergillus niger hypothetical protein XP_059602272.1 514613 D 5061 CDS An14g02030 4987059 join(516645..516694,516753..516854,516908..517192,517245..518892,518945..519016,519100..519911,519993..520095) I 1 NT_166529.1 Similarity: the ORF shows local similarity to SPAC57A7. 05 of S. pombe: the two proteins are similar to each other along a stretch of about 350 amino acids in length.; Title: similarity to hypothetical protein SPAC57A7.05 - Schizosaccharomyces pombe; uncharacterized protein 520095 4987059 An14g02030 Aspergillus niger uncharacterized protein XP_059602273.1 516645 D 5061 CDS An14g02040 4987060 complement(520364..>521158) I 1 NT_166529.1 Remark: contig An14c0100 contains a C-terminally truncated ORF with similarity to the N-terminal region of A. oryzae mreA, indicating that a gap of ~1000 bp with the central region of a predicted isoamyl alcohol oxidase is between contig An14c0090 and An14c0100.; Remark: the ORF is N-terminally truncated due to the contig border.; Similarity: the ORF shows local similarity along a stretch of more than 100 amino acids to mreA of A. oryzae; the local similarity is restricted to the C-terminus of the ORF.; Title: similarity to hypothetical isoamyl alcohol oxidase mreA - Aspergillus oryzae [truncated ORF]; uncharacterized protein 521158 4987060 An14g02040 Aspergillus niger uncharacterized protein XP_001400830.3 520364 R 5061 CDS An14g02050 84592929 complement(<521322..521632) I 1 NT_166529.1 Remark: contig An14c0100 contains a N-terminally truncated ORF with similarity to the C-terminal region of A. oryzae mreA, indicating that a gap of ~1000 bp with the central region of a predicted isoamyl alcohol oxidase is between contig An14c0090 and An14c0100.; Remark: the ORF is C-terminally truncated due to contig border.; Similarity: similarity is between the predicted A. niger protein and the N-terminal region of A. oryzae mreA.; Title: similarity to hypothetical isoamyl alcohol oxidase mreA - Aspergillus oryzae [truncated ORF]; uncharacterized protein 521632 84592929 An14g02050 Aspergillus niger uncharacterized protein XP_059602274.1 521322 R 5061 CDS An14g02060 4987062 join(522251..523431,523521..523564,523804..523970) I 1 NT_166529.1 Catalytic activity: trans,trans-farnesyl diphosphate <=> aristolochene + diphosphate; Function: Ari1 of P. roqueforti synthesizes aristolochene.; Pathway: Ari1 of P. roqueforti is a component of the sesquiterpenoid biosynthetic pathway.; Remark: Ari1 of P. roqueforti is a member of the terpene cyclase group of enzymes.; Remark: aristolochene is the likely precursor of the sesquiterpenoid PR-toxin, produced by Penicillium roqueforti.; Remark: the Ari1 gene of P. roqueforti encodes the sesquiterpene cyclase, also called aristolochene synthase.; Similarity: more than 100 c-terminal amino acids of the ORF are not included in the alignment with Ari1 of P. roqueforti.; Title: similarity to aristolochene synthase Ari1 -Penicillium roqueforti; See PMID 8440737; uncharacterized protein 523970 4987062 An14g02060 Aspergillus niger uncharacterized protein XP_001400832.3 522251 D 5061 CDS An14g02070 4987063 complement(join(524173..524499,524562..524798,524846..524905,524950..525043,525090..525244,525503..525508,525565..525601,525693..525928)) I 1 NT_166529.1 Similarity: the ORF has a local similarity to celE of C. thermocellum encompassing ca. 250 C-terminal amino acids.; Title: weak similarity to endo-1,4-beta-glucanase celE - Clostridium thermocellum; See PMID 3066698; uncharacterized protein 525928 4987063 An14g02070 Aspergillus niger uncharacterized protein XP_059602275.1 524173 R 5061 CDS An14g02080 4987064 527489..528931 I 1 NT_166529.1 Catalytic activity: prolidase of A. esteraromaticum hydrolysis Xaa-|-Pro dipeptides.; Remark: a substrate for prolidase of A. esteraromaticum is Pro-Hyp.; Similarity: 100 N-terminal amino acids of the ORF are not aligned with prolidase of A. esteraromaticum.; Similarity: the ORF shows also strong similarity to (hypothetical) aryldialkylphosphatases.; Title: strong similarity to prolidase -Aureobacterium esteraromaticum; See PMID 9989239; uncharacterized protein 528931 4987064 An14g02080 Aspergillus niger uncharacterized protein XP_059602276.1 527489 D 5061 CDS An14g02090 4987065 complement(join(529598..529764,529832..529915,529974..530247)) I 1 NT_166529.1 hypothetical protein 530247 4987065 An14g02090 Aspergillus niger hypothetical protein XP_001400835.1 529598 R 5061 CDS An14g02100 4987066 complement(531875..532741) I 1 NT_166529.1 Function: the MP1 protein of P. marneffei is a cell wall mannoprotein with high affinity for concanavalin A.; Localization: immunogold staining indicated that MP1 of P. marneffei is present in the cell walls, hyphae, and conidia.; Remark: the MP1 protein of P. marneffei acts as a immunogen: P. marneffei infected patients develop a specific antibody response against MP1.; Similarity: the MP1 protein of P. marneffei is 159 amino acids longer than the ORF; the complete ORF sequence is encompassed in the alignment between the two proteins.; Similarity: the ORF overlaps with the A. niger ESTs an_3233 in EMBLEST:BE758971, an_3139 in EMBLEST:BE758883, an_2550 in EMBLEST:BE759683, an_1941 in EMBLEST:BE760597,an_3048 in EMBLEST:BE758804, and an_2258 in EMBLEST:BE759444.; Title: strong similarity to cell wall antigen MP1 -Penicillium marneffei; cell wall; See PMID 9488383; uncharacterized protein 532741 4987066 An14g02100 Aspergillus niger uncharacterized protein XP_001400836.1 531875 R 5061 CDS An14g02110 84592930 join(534583..534628,534740..534972) I 1 NT_166529.1 Remark: the ORF has an unusual exon/intron structure for A. niger and is short in length.; Title: questionable ORF; uncharacterized protein 534972 84592930 An14g02110 Aspergillus niger uncharacterized protein XP_059602277.1 534583 D 5061 CDS An14g02120 84592931 join(536345..536361,537002..537030,537101..537219,537348..537485,537539..537562) I 1 NT_166529.1 Remark: the ORF has an unusual exon/intron structure for A. niger and is short in length.; hypothetical protein 537562 84592931 An14g02120 Aspergillus niger hypothetical protein XP_059602278.1 536345 D 5061 CDS An14g02130 4987069 join(537833..538086,538141..539452,539885..540111,540172..540422,540558..541429,541553..541615,541670..541727,541786..542187,542393..542547,542600..542661,542708..543998,544055..544222) I 1 NT_166529.1 Function: atpc-2 of A. thaliana binds to a promoter region located immediately upstream of the CAAT box of the spinach AtpC gene (encoding the gamma subunit of the ATP synthase) and thereby prevents CBF binding, thus repressing AtpC gene expression.; Remark: atpc-2 of A. thaliana has a modular structure.; Similarity: atpc-2 of A. thaliana shows homology to helicases.; Similarity: the ORF has local similarity with atpc-2 of A. thaliana: only the N-terminal half of the ORF is included in the alignment.; Similarity: the ORF shows strong similarity to patent WO0118208 in TREMBL:AX098230_1 and to other hypothetical proteins.; Title: similarity to transcription repressor protein AtPC-2 - Arabidopsis thaliana; See PMID 11274172; uncharacterized protein 544222 4987069 An14g02130 Aspergillus niger uncharacterized protein XP_059602279.1 537833 D 5061 CDS An14g02140 4987070 join(545578..545595,545642..545698,545749..545764,545812..545928,545976..546043) I 1 NT_166529.1 Remark: CDPK1 of M. polymorpha is alternatively spliced.; Title: weak similarity to Ca-dependent protein kinase CDPK1 - Marchantia polymorpha; See PMID 10202816; uncharacterized protein 546043 4987070 An14g02140 Aspergillus niger uncharacterized protein XP_001400840.1 545578 D 5061 CDS An14g02150 4987071 join(546525..546609,546653..546798,546844..547264,547327..547995,548045..548118,548193..548234) I 1 NT_166529.1 Function: cpdS of A. phoenicis removes acidic,neutral and basic amino acids as well as proline from the C-terminal position at pH 2-5.; Remark: A. phoenicis is also called A. saitoi.; Remark: cpdS of A. phoenicis has a catalytic triad comprising Asp-His-Ser.; Remark: cpdS of A. phoenicis is a member of serine carboxypeptidase family .; Similarity: the ORF shows also strong similarity to serine-type carboxypeptidase of A. niger.; Title: strong similarity to serine-type carboxypeptidase precursor cpdS - Aspergillus phoenicis; See PMID 7772020; uncharacterized protein 548234 4987071 An14g02150 Aspergillus niger uncharacterized protein XP_059602280.1 546525 D 5061 CDS An14g02160 4987072 join(548630..548778,548854..548939,549007..549044,549113..549168,549253..549410,549460..549659,549821..550210) I 1 NT_166529.1 Catalytic activity: an alcohol + NAD(+) <=> an aldehyde or ketone + NADH; Function: adhA of S. meliloti reduces alcohols.; Remark: Rhizobium meliloti is also called Sinorhizobium meliloti.; Remark: adhA of S. meliloti belongs to the zinc-containing alcohol dehydrogenase family.; Title: strong similarity to alcohol dehydrogenase adhA - Sinorhizobium meliloti; See PMID 9659380; uncharacterized protein 550210 4987072 An14g02160 Aspergillus niger uncharacterized protein XP_059602281.1 548630 D 5061 CDS An14g02170 4987073 complement(join(550398..550773,550860..551077,551192..551386)) I 1 NT_166529.1 Catalytic activity: cut A of F. solani hydrolysis cutin, a polyester that forms the structure of plant cuticle.; Function: cutinases allow pathogenic fungi to penetrate through the cuticular barrier of the host plant during the initial phase of fungal infection.; Induction: cut A of F. solani is induced by cutin.; Remark: cut A of F. solani belongs to the cutinase family.; Title: strong similarity to cutinase precursor cutA - Fusarium solani; extracellular/secretion proteins; See PMID 10556791; See PMID 11099798; uncharacterized protein 551386 4987073 An14g02170 Aspergillus niger uncharacterized protein XP_001400843.1 550398 R 5061 CDS An14g02180 4987074 complement(join(552582..552642,552691..553033,553088..553464,553520..553880,553949..554225)) I 1 NT_166529.1 Catalytic activity: UDP-glucose + D-glucose 6-phosphate <=> UDP + alpha,alpha-trehalose 6-phosphate.; Induction: transcription of tpsB of A. niger was hardly detectable at ambient temperatures but was enhanced strongly upon heat shock, which agrees with the presence of several copies of a C4T stress-responsive element in its 5'-upstream sequences.; Remark: the ORF shows strong similarity to A. niger trehalose synthase of patent WO9824882-A1 in PATENTPROT:AAW49027.; Remark: tpsB of A. niger belongs to other fungal tps1.; Title: strong similarity to trehalose-6-phosphate synthase tpsB - Aspergillus niger; See PMID 9006911; uncharacterized protein 554225 4987074 An14g02180 Aspergillus niger uncharacterized protein XP_001400844.1 552582 R 5061 CDS An14g02190 4987075 complement(join(554805..555140,555187..556088,556159..556273)) I 1 NT_166529.1 Remark: the ORF shows local similarity to the hypothetical membrane protein YGL247w of S. cerevisiae: only 144 amino acids (about 1/3) of the ORF are included in the alignment.; Title: similarity to hypothetical membrane protein YGL247w - Saccharomyces cerevisiae; uncharacterized protein 556273 4987075 An14g02190 Aspergillus niger uncharacterized protein XP_001400845.1 554805 R 5061 CDS An14g02200 4987076 complement(join(557150..557528,557577..557752)) I 1 NT_166529.1 Remark: the ORF overlaps with the A. niger ESTs an_2365 in EMBLEST:BE759538 and an_1441 in EMBLEST:BE760308: the former is a nearly complete overlap of both the EST and the ORF, the latter overlap, however,is very short.; Title: strong similarity to EST an_2365 -Aspergillus niger; uncharacterized protein 557752 4987076 An14g02200 Aspergillus niger uncharacterized protein XP_001400846.1 557150 R 5061 CDS An14g02210 4987077 complement(560023..561048) I 1 NT_166529.1 Remark: IgA-specific metalloendopeptidase (EC: 3. 4. 24. 13) of N. meningitidis acts on the hinge region of the heavy chains of human IgA immunoglobulin, cleaving exclusively Pro-|-Thr and Pro-|-Ser bonds.; Remark: the ORF shows weak local similarity (over a stretch of 82 amino acids) to SFAG 2 carboxypeptidase Y of A. niger patent WO9609397-A1 in PATENTPROT:AAR96738.; Similarity: the ORF shows local similarity to two IgA-specific metalloendopeptidases (NMA0905 and NMB0700) of N. meningitidis: the alignments encompass only 152 amino acids of the ORF.; Title: strong similarity to hypothetical protein SPCC1620.10 - Schizosaccharomyces pombe; See PMID 7783620; uncharacterized protein 561048 4987077 An14g02210 Aspergillus niger uncharacterized protein XP_001400847.1 560023 R 5061 CDS An14g02220 84592932 complement(join(561194..561264,561346..561417,561459..561546,561640..561702)) I 1 NT_166529.1 Remark: the ORF is short in length.; hypothetical protein 561702 84592932 An14g02220 Aspergillus niger hypothetical protein XP_059602282.1 561194 R 5061 CDS An14g02230 4987079 complement(join(562447..562884,562938..563169,563219..563306,563356..564146,564291..564484)) I 1 NT_166529.1 Function: dsk1 of S. pombe encodes a kinase, which auto-phosphorylates as well as phosphorylates myelin basic protein (MBP).; Function: dsk1 of S. pombe may serve as a cell cycle regulator in coordinating pre-mRNA splicing.; Localization: dsk1 of S. pombe locates in the cytoplasm in G2-arrested cells, in mitotically arrested cells, however, it resides in the nucleus.; Phenotype: the haploid gene disruptant of dsk1 of S. pombe is viable; high dosage of dsk1, however, strongly delays the G2/M progression.; Remark: dsk1 of S. pombe belongs to the ser/thr family of protein kinases.; Remark: in mitotically arrested cells compared to interphase-arrested cells dsk1 of S. pombe is higher phosphorylated, and has a higher kinase activity.; Title: strong similarity to dis1-suppressing protein kinase dsk1p - Schizosaccharomyces pombe; See PMID 8485317; See PMID 9488736; See PMID 10629038; uncharacterized protein 564484 4987079 An14g02230 Aspergillus niger uncharacterized protein XP_001400849.1 562447 R 5061 CDS An14g02240 4987080 join(566362..567457,567566..567616,567784..567803) I 1 NT_166529.1 Remark: the ORF overlaps C-terminally with the A. niger EST an_0349 in EMBLEST:BE760713.; Remark: the gene CG16717 of D. melanogaster is from genomic scaffold 142000013386050 section 17 of 54.; Similarity: the ORF shows also strong similarity to 239AB and 239FB of H. sapiens; these proteins are localized at a chromosomal region associated with WAGR (Wilms tumor,aniridia, genitourinary anomalies, and mental retardation).; Similarity: the ORF shows local strong similarity to the gene CG16717 of D. melanogaster: 100 C-terminal amino acids of the ORF are not included in the alignment between the two proteins.; Title: strong similarity to hypothetical protein encoded by CG16717 - Drosophila melanogaster; uncharacterized protein 567803 4987080 An14g02240 Aspergillus niger uncharacterized protein XP_001400850.3 566362 D 5061 CDS An14g02250 4987081 complement(join(567877..568956,569014..569327,569380..569488)) I 1 NT_166529.1 Catalytic activity: (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c.; Complex: L-lactate dehydrogenase of P. anomala is composed of a cytochrome b2 core complexed to flavodehydrogenase (a tetramer).; Function: L-lactate dehydrogenase of P. anomala is an electron transfer enzyme.; Pathway: L-lactate dehydrogenase of P. anomala takes part in the pyruvate metabolism.; Remark: L-lactate dehydrogenase (EC: 1. 1. 2. 3.) is also called (flavo)cytochrome b2.; Remark: Pichia anomala is also called Hansenula anomala.; Similarity: the ORF shows also strong similarity to glycolate oxidases of different species (EC 1. 1. 3. 15).; Title: strong similarity to flavocytochrome b2 L-lactate dehydrogenase CYB2 - Pichia anomala; localisation:mitochondrion; See PMID 8240249; See PMID 8589063; See PMID 8589064; See PMID 9230706; uncharacterized protein 569488 4987081 An14g02250 Aspergillus niger uncharacterized protein XP_001400851.1 567877 R 5061 CDS An14g02260 4987082 complement(join(570840..571160,571284..571675,571730..571775)) I 1 NT_166529.1 Remark: Rab proteins constitute a family of GTP-binding proteins that are located in distinct intracellular compartments and play a role in the regulation of vesicular trafficking.; Remark: Rab proteins contain four highly conserved peptide sequences involved in GTP binding and hydrolysis; Title: strong similarity to small GTPase Rab24 from patent CN1257926-A - Mus musculus; uncharacterized protein 571775 4987082 An14g02260 Aspergillus niger uncharacterized protein XP_059602283.1 570840 R 5061 CDS An14g02270 84592933 join(572094..572147,572193..572432,572523..572675) I 1 NT_166529.1 hypothetical protein 572675 84592933 An14g02270 Aspergillus niger hypothetical protein XP_059602284.1 572094 D 5061 CDS An14g02280 4987084 join(575835..575837,576236..576633,576699..577268,577348..577405) I 1 NT_166529.1 Remark: the patent protein entry Y35412 which also shows weak similarity was not found in patent database.; Title: similarity to hypothetical protein encoded by An02g01160 - Aspergillus niger; uncharacterized protein 577405 4987084 An14g02280 Aspergillus niger uncharacterized protein XP_059602285.1 575835 D 5061 CDS An14g02290 4987085 complement(join(577851..578151,578213..578530,578600..579186,579235..579583,579649..580025,580081..580321,580369..580639,580689..581352)) I 1 NT_166529.1 Induction: the mRNA for the alpha 1 isoform of the NKAA1 gene from R. norvegicus, is expressed in all fetal and adult rat tissues examined.; Remark: Hydrolysis of ATP is coupled with the exchange of Na(+) and K(+) ions, and is specifically inhibited by ouabain.; Remark: designated alpha-S form; thought to arise from alpha-1 chain by post-translational modification; Remark: the isoform diversity of the Na,K-ATPase alpha subunit may provide a biochemical basis for Na,K-ATPase functional diversity.; Title: strong similarity to Na+/K+-exchanging ATPase alpha-1 chain NKAA1 - Rattus norvegicus; plasma membrane; See PMID 2163680; See PMID 2822726; uncharacterized protein 581352 4987085 An14g02290 Aspergillus niger uncharacterized protein XP_059602286.1 577851 R 5061 CDS An14g02300 4987086 complement(join(582193..582657,582714..583359,583409..583716)) I 1 NT_166529.1 Remark: the matching coding sequence was isolated by carrying out RT-PCR on all of the mRNA obtained from A. thaliana.; Remark: the patent does not provide information about the function of the protein.; Title: similarity to protein fragment from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 583716 4987086 An14g02300 Aspergillus niger uncharacterized protein XP_001400856.1 582193 R 5061 CDS An14g02310 84592934 join(584697..584744,584914..585159,585232..585295,585348..585463,585550..585633) I 1 NT_166529.1 hypothetical protein 585633 84592934 An14g02310 Aspergillus niger hypothetical protein XP_059602287.1 584697 D 5061 CDS An14g02320 4987088 complement(585819..586838) I 1 NT_166529.1 Similarity: the similarities are mainly based on repetetive structures.; Title: weak similarity to splicing coactivator subunit SRm300 - Homo sapiens; uncharacterized protein 586838 4987088 An14g02320 Aspergillus niger uncharacterized protein XP_001400858.1 585819 R 5061 CDS An14g02330 84592935 complement(join(587904..588068,588169..588231,588326..588431,588516..588895)) I 1 NT_166529.1 hypothetical protein 588895 84592935 An14g02330 Aspergillus niger hypothetical protein XP_059602288.1 587904 R 5061 CDS An14g02340 84592936 complement(join(589166..589677,589730..589982,590038..590220)) I 1 NT_166529.1 Similarity: the similarities are mainly based on repetetive structures.; Title: weak similarity to nucleolar phosphoprotein -Xenopus laevis; uncharacterized protein 590220 84592936 An14g02340 Aspergillus niger uncharacterized protein XP_059602289.1 589166 R 5061 CDS An14g02350 4987091 complement(join(590715..590959,591023..591557)) I 1 NT_166529.1 Similarity: the ORF also shows strong similarity to the EST an_3030 from Aspergillus niger.; Title: weak similarity to protein belonging to the presenilin superfamily protein S182 - Mus musculus; uncharacterized protein 591557 4987091 An14g02350 Aspergillus niger uncharacterized protein XP_001400861.1 590715 R 5061 CDS An14g02360 4987092 complement(join(592612..592992,593074..593334,593420..593460,593551..593629)) I 1 NT_166529.1 Complex: the human U2 snRNP-specific protein A' (U2A') forms a ternary complex together with the U2B' protein and the hairpin-loop IV of U2 small nuclear RNA.; Function: the human U2 snRNP-specific protein A' is involved in splicing of mRNA.; Remark: the human U2 snRNP-specific protein A' does not contain segments homologous to the RNP consensus sequences RNP1 and RNP2 of several RNA-binding proteins.; Title: strong similarity to U2 snRNA-specific protein A - Homo sapiens; nucleus; See PMID 9716128; See PMID 2928112; uncharacterized protein 593629 4987092 An14g02360 Aspergillus niger uncharacterized protein XP_001400862.1 592612 R 5061 CDS An14g02370 4987093 complement(join(594172..596144,596217..596337,596392..596426,596494..596503)) I 1 NT_166529.1 Catalytic activity: NTP + H(2)O <=> NDP + phosphate.; Function: the apyrase Ynd1 from S. cerevisiae is required for golgi N- and O-glycosylation and cell wall integrity.; Golgi; Phenotype: S. cerevisiae ynd1 null mutants are defective in O- and N-linked glycosylation in the Golgi compartments.; Remark: synonyms for Ynd1 from S. cerevisiae are Yej5 and YER005w.; Title: strong similarity to nucleoside diphosphatase Ynd1 - Saccharomyces cerevisiae; See PMID 10409709; uncharacterized protein 596503 4987093 An14g02370 Aspergillus niger uncharacterized protein XP_001400863.1 594172 R 5061 CDS An14g02380 84592937 join(597428..597516,597652..597725,597808..597938) I 1 NT_166529.1 hypothetical protein 597938 84592937 An14g02380 Aspergillus niger hypothetical protein XP_059602290.1 597428 D 5061 CDS An14g02390 4987095 complement(join(598327..599025,599081..599401,599447..599627,599685..599899,599973..599981)) I 1 NT_166529.1 Function: Mep2 from S. cerevisiae is a transporter which uses ammonium as a nitrogen source.; Remark: Mep2 from S. cerevisiae is an ammonium sensor, generating a signal to regulate filamentous growth in response to ammonium starvation.; Remark: Mep2 from S. cerevisiae, a high affinity ammonium permease, is required for pseudohyphal differentiation in response to ammonium limitation.; Remark: the synonyms for Mep2 from S. cerevisiae are YNL142w, N1207 and N1820.; Similarity: Mep2 from S. cerevisiae belongs to the Amt1/nrgA/Mep family of ammonium transporters.; Title: strong similarity to ammonium transport protein Mep2 - Saccharomyces cerevisiae; plasma membrane; See PMID 9234685; See PMID 9482721; See PMID 11069679; See PMID 8062822; uncharacterized protein 599981 4987095 An14g02390 Aspergillus niger uncharacterized protein XP_001400865.3 598327 R 5061 CDS An14g02400 84592938 complement(join(600435..600560,600637..600695,600806..601004)) I 1 NT_166529.1 hypothetical protein 601004 84592938 An14g02400 Aspergillus niger hypothetical protein XP_059602291.1 600435 R 5061 CDS An14g02410 4987097 join(601918..601997,602070..603618) I 1 NT_166529.1 Title: similarity to hypothetical conserved protein encoded by 17E5.150 - Neurospora crassa; uncharacterized protein 603618 4987097 An14g02410 Aspergillus niger uncharacterized protein XP_001400867.3 601918 D 5061 CDS An14g02420 4987098 complement(join(603676..603687,603848..603916,604075..604702,604755..606590,606638..606993)) I 1 NT_166529.1 Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942; uncharacterized protein 606993 4987098 An14g02420 Aspergillus niger uncharacterized protein XP_001400868.3 603676 R 5061 CDS An14g02430 84592939 complement(join(608192..608239,608376..608410,608440..608881)) I 1 NT_166529.1 Remark: the matching coding sequence was isolated by carrying out RT-PCR on all of the mRNA obtained from A. thaliana.; Title: weak similarity to protein fragment from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 608881 84592939 An14g02430 Aspergillus niger uncharacterized protein XP_059602292.1 608192 R 5061 CDS An14g02440 84592940 complement(join(609959..610026,610127..610331,610524..610532)) I 1 NT_166529.1 Similarity: the ORF shows similarity to the EST of patent WO200056762-A2 from Aspergillus niger.; Title: similarity to EST SEQ ID NO:4362 from patent WO200056762-A2 - Aspergillus niger; uncharacterized protein 610532 84592940 An14g02440 Aspergillus niger uncharacterized protein XP_059602293.1 609959 R 5061 CDS An14g02450 4987101 complement(join(610901..611290,611359..611655,611706..612032)) I 1 NT_166529.1 Induction: Aqy2-1 from S. cerevisiae was detected only during the exponential growth phase in rich medium containing glucose.; Localization: Aqy2-1 from S. cerevisiae is located on the endoplasmic reticulum as well as on the plasma membrane.; Remark: AQY2 is disrupted by a stop codon in most S. cerevisiae strains.; Remark: the synonym for Aqy2 from S. cerevisiae is YLL052c.; Similarity: Aqy2 from S. cerevisiae is a member of mip family of aquaglyceroporin transmembrane channels.; Title: strong similarity to aquaporin water channel protein Aqy2 - Saccharomyces cerevisiae; plasma membrane; See PMID 11158584; See PMID 11168368; uncharacterized protein 612032 4987101 An14g02450 Aspergillus niger uncharacterized protein XP_059602294.1 610901 R 5061 CDS An14g02460 4987102 613729..614982 I 1 NT_166529.1 Cofactor: FAD and protoheme IX were bound as cofactors by fhp of A. eutrophus.; Function: isogenic Fhp-negative mutant did not accumulate nitrous oxide during denitrification with nitrite as electron acceptor.; Function: isogenic Fhp-negative mutants showed no significant delay in aerobic or anaerobic growth.; Remark: Ralstonia eutropha = Alcaligenes eutrophus.; Remark: fhp of A. eutrophus contains a phospholipid-binding site.; Title: strong similarity to flavohemoglobin Fhp -Alcaligenes eutrophus; See PMID 8125952; See PMID 10336624; uncharacterized protein 614982 4987102 An14g02460 Aspergillus niger uncharacterized protein XP_001400872.1 613729 D 5061 CDS An14g02470 4987103 complement(join(615319..616065,616137..617113,617181..617292)) I 1 NT_166529.1 Remark: the human PRO304 protein is one of a couple of secreted and transmembrane polypeptides which could be used for treatment of skin diseases.; Remark: the patent WO200104311-A1 does not provide additional functional information.; Similarity: the ORF also shows strong similarities to the sequence of patents US 5821104 and WO9614404-A1 and the EST an_3412 from Aspergillus niger.; Title: strong similarity to protein PRO304 from patent WO200104311-A1 - Homo sapiens; uncharacterized protein 617292 4987103 An14g02470 Aspergillus niger uncharacterized protein XP_001400873.1 615319 R 5061 CDS An14g02480 84592941 complement(join(619138..619309,619402..619647,620039..620134,620244..620337,620558..620704,620782..620865,620988..621104,621584..621639,621690..622012)) I 1 NT_166529.1 Title: weak similarity to catalase protein from patent CN1219588-A - Bacillus thermoglucosidasius; uncharacterized protein 622012 84592941 An14g02480 Aspergillus niger uncharacterized protein XP_059602295.1 619138 R 5061 CDS An14g02490 4987105 join(622777..622951,622998..623380) I 1 NT_166529.1 Title: weak similarity to protein from patent WO200056892-A1 - Streptomyces albulus; uncharacterized protein 623380 4987105 An14g02490 Aspergillus niger uncharacterized protein XP_001400875.1 622777 D 5061 CDS An14g02500 4987106 join(623881..624240,624309..624657,624747..625669) I 1 NT_166529.1 Title: similarity to hypothetical protein YER080w -Saccharomyces cerevisiae; uncharacterized protein 625669 4987106 An14g02500 Aspergillus niger uncharacterized protein XP_059602296.1 623881 D 5061 CDS An14g02510 84592942 join(626619..626983,627033..627294,627420..627654,627793..627998) I 1 NT_166529.1 Title: weak similarity to hypothetical protein of the gtp1/obg family PAB0558 - Pyrococcus abyssi; uncharacterized protein 627998 84592942 An14g02510 Aspergillus niger uncharacterized protein XP_059602297.1 626619 D 5061 CDS An14g02520 84592943 join(629471..629488,629535..629711,629801..629931,630019..630184) I 1 NT_166529.1 Title: weak similarity to hypothetical protein T04D1.4 - Caenorhabditis elegans; uncharacterized protein 630184 84592943 An14g02520 Aspergillus niger uncharacterized protein XP_059602298.1 629471 D 5061 CDS An14g02530 84592944 complement(join(631917..632205,632295..632320)) I 1 NT_166529.1 Title: weak similarity to protein serine/threonine kinase-1 psk1 - Plasmodium falciparum; uncharacterized protein 632320 84592944 An14g02530 Aspergillus niger uncharacterized protein XP_059602299.1 631917 R 5061 CDS An14g02540 4987110 complement(join(633740..634360,634421..634750)) I 1 NT_166529.1 Title: weak similarity to sterol regulatory element-binding protein-1 SREBP-1 - Mus musculus; uncharacterized protein 634750 4987110 An14g02540 Aspergillus niger uncharacterized protein XP_001400880.1 633740 R 5061 CDS An14g02550 84592945 complement(join(635958..636173,636238..636254,636404..636464,636642..636729,636968..637182,637215..637391)) I 1 NT_166529.1 hypothetical protein 637391 84592945 An14g02550 Aspergillus niger hypothetical protein XP_059604617.1 635958 R 5061 CDS An14g02560 4987112 complement(join(638418..639095,639155..639412)) I 1 NT_166529.1 Title: similarity to protein from patent EP0845532 -Pseudomonas sp.; uncharacterized protein 639412 4987112 An14g02560 Aspergillus niger uncharacterized protein XP_001400882.1 638418 R 5061 CDS An14g02570 4987113 complement(join(641199..642426,642473..642786)) I 1 NT_166529.1 Title: similarity to EST Nig077 - Aspergillus niger; uncharacterized protein 642786 4987113 An14g02570 Aspergillus niger uncharacterized protein XP_001400883.1 641199 R 5061 CDS An14g02580 84592946 complement(join(643976..644385,644470..644581)) I 1 NT_166529.1 hypothetical protein 644581 84592946 An14g02580 Aspergillus niger hypothetical protein XP_059604618.1 643976 R 5061 CDS An14g02590 4987115 join(645242..645401,645496..646952) I 1 NT_166529.1 Function: transcript level analyses demonstrate that gabA is subject to carbon catabolite and nitrogen metabolite repression.; Similarity: shows also similarity to several putative fungal aminoacid permeases.; Title: strong similarity to GABA permease gabA -Aspergillus nidulans; See PMID 10320578; uncharacterized protein 646952 4987115 An14g02590 Aspergillus niger uncharacterized protein XP_001400885.3 645242 D 5061 CDS An14g02600 84592947 complement(join(647131..647308,647803..647899,647997..648067,648145..648188,648272..648313)) I 1 NT_166529.1 hypothetical protein 648313 84592947 An14g02600 Aspergillus niger hypothetical protein XP_059604619.1 647131 R 5061 CDS An14g02610 4987117 join(648681..648878,648929..648973,649026..649436,649490..650034,650085..650590,650640..651249,651298..651572,651620..651795,651842..651935,651983..652290,652341..652547,652597..652756,652803..653242,653292..653390) I 1 NT_166529.1 Localization: integral membrane protein.; Remark: cDNA of atrB can complement the drug hypersensitivity associated with PDR5 deficiency in S. cerevisiae.; Similarity: belongs to the ATP-binding transport protein family (ABC transporters).; Title: strong similarity to ATP-binding cassette multidrug transport protein atrB - Aspergillus nidulans; plasma membrane; See PMID 9180695; uncharacterized protein 653390 4987117 An14g02610 Aspergillus niger uncharacterized protein XP_001400887.1 648681 D 5061 CDS An14g02620 4987118 complement(join(653596..653784,653942..654011,654043..654566)) I 1 NT_166529.1 Title: similarity to hypothetical protein encoded by An13g01640 - Aspergillus niger; uncharacterized protein 654566 4987118 An14g02620 Aspergillus niger uncharacterized protein XP_059604620.1 653596 R 5061 CDS An14g02630 4987119 655590..656462 I 1 NT_166529.1 Similarity: short stretches of weak similarity are due to low complexity regions, and do not look significant.; hypothetical protein 656462 4987119 An14g02630 Aspergillus niger hypothetical protein XP_001400889.1 655590 D 5061 CDS An14g02640 4987120 join(656680..657702,657739..657879) I 1 NT_166529.1 Remark: the patent database entry represents one of the proteins encoded by all the open reading frames in the complete genome of Chlamydia pneumoniae.; Similarity: the predicted ORF indeed shows some structural motif in common with such enzymes, but the similarity is too weak to draw conclusions about the function.; Similarity: the predicted ORF shows also a much weaker similarity to several proteins defined as cobalamin-independent methionine synthase on the basis of the similarity to E. coli metE gene.; Title: strong similarity to transmembrane protein from patent WO9927105-A2 - Chlamydia pneumoniae; uncharacterized protein 657879 4987120 An14g02640 Aspergillus niger uncharacterized protein XP_059604621.1 656680 D 5061 CDS An14g02650 4987121 join(658367..658471,658537..>659257) I 1 NT_166529.1 Catalytic activity: acid phosphatases also catalyze transphosphorylations.; Catalytic activity: acid phosphatases catalyze the hydrolysis of an ortophosphoric monoester to alcohol + ortophosphate, with wide specificity.; Remark: a putative sequencing error results in a frameshift.; Similarity: the predicted ORF also shows similarity to a phospholipase of Fusarium venenatum, patentnumber WO200041509-A2.; Similarity: the predicted ORF also shows similarity to a variety of hypothetical proteins annotated as survival factors, due to the similarity to E. coli SurE, a protein with unknown molecular function, but required for survival.; Title: similarity to acid phosphatase PHO2 -Yarrowia lipolytica [putative frameshift]; putative frameshift; See PMID 1423722; See PMID 7928962; uncharacterized protein 659257 4987121 An14g02650 Aspergillus niger uncharacterized protein XP_059604622.1 658367 D 5061 CDS An14g02660 4987122 join(659814..660043,660132..660642) I 1 NT_166529.1 Title: strong similarity to hypothetical necrosis and ethylene inducing protein BH0395 - Bacillus halodurans; uncharacterized protein 660642 4987122 An14g02660 Aspergillus niger uncharacterized protein XP_001400892.1 659814 D 5061 CDS An14g02670 4987123 complement(join(660991..661164,661351..662226)) I 1 NT_166529.1 Function: the predicted ORF shows strong similarity to many glycosidases involved in the catabolism of different polysaccharides.; Induction: T. reesei egl4 is regulated in the same manner as other cellulase genes of this fungus.; Title: strong similarity to endoglucanase IV egl4 -Trichoderma reesei; extracellular/secretion proteins; See PMID 9370370; uncharacterized protein 662226 4987123 An14g02670 Aspergillus niger uncharacterized protein XP_059604623.1 660991 R 5061 CDS An14g02680 84592948 complement(join(662484..662714,662976..663023,663069..663260,663414..663491,663542..663648,663858..663917,664017..664167)) I 1 NT_166529.1 Title: weak similarity to hypothetical xylosidase/arabinosidase - Streptomyces coelicolor; uncharacterized protein 664167 84592948 An14g02680 Aspergillus niger uncharacterized protein XP_059604624.1 662484 R 5061 CDS An14g02690 84592949 join(664805..665010,665063..665189) I 1 NT_166529.1 Title: weak similarity to hypothetical protein MT4026.1 - Mycobacterium tuberculosis; uncharacterized protein 665189 84592949 An14g02690 Aspergillus niger uncharacterized protein XP_059604625.1 664805 D 5061 CDS An14g02700 4987126 join(665654..666038,666092..666155,666205..666648,666706..667312,667366..667701) I 1 NT_166529.1 Function: itr2 of S. pombe is a transporter for myo-inositol.; Similarity: itr2 of S. pombe belongs to the sugar transporter family.; Similarity: the predicted ORF shows a much stronger similarity to a putative myo-inositol transporter of N. crassa.; Title: strong similarity to myo-inositol transporter 2 itr2p - Schizosaccharomyces pombe; plasma membrane; See PMID 9560432; uncharacterized protein 667701 4987126 An14g02700 Aspergillus niger uncharacterized protein XP_001400896.1 665654 D 5061 CDS An14g02710 84592950 complement(join(668431..668704,668774..668871)) I 1 NT_166529.1 Similarity: the predicted ORF shows a weak, but consistent similarity to different vertebrate inward rectifying potassium channels.; Title: weak similarity to inward rectifier potassium channel protein cIRK1 - Gallus gallus; See PMID 7642595; uncharacterized protein 668871 84592950 An14g02710 Aspergillus niger uncharacterized protein XP_059604626.1 668431 R 5061 CDS An14g02720 4987128 join(671492..671688,671746..671759,671815..671887,671943..672274,672323..672466,672517..672731,672778..672975,673025..673052,673101..673216,673266..673349) I 1 NT_166529.1 Function: mtr of N. crassa is required for the transport of neutral aliphatic and aromatic amino acids.; Similarity: mtr of N. crassa belongs to the Amino Acid/Auxin Permease (AAAP) family.; Title: strong similarity to neutral amino acid permease mtr - Neurospora crassa; plasma membrane; See PMID 8001794; See PMID 1838345; uncharacterized protein 673349 4987128 An14g02720 Aspergillus niger uncharacterized protein XP_001400898.1 671492 D 5061 CDS An14g02730 84592951 complement(join(673502..673650,673671..673753,673841..673921,673946..674046,674213..674269)) I 1 NT_166529.1 Title: weak similarity to thioredoxin reductase tr/trx - Mycobacterium leprae; See PMID 7476189; uncharacterized protein 674269 84592951 An14g02730 Aspergillus niger uncharacterized protein XP_059604627.1 673502 R 5061 CDS An14g02740 4987130 join(675426..675525,675579..675686,675737..676277,676330..677188) I 1 NT_166529.1 Function: high affinity glucose transporter.; Remark: expression of HGT1 from Kluyveromyces lactis is constitutive (in contrast to RAG1, the major gene for low-affinity glucose uptake in K. lactis) and is controlled by several genes also known to affect expression of RAG1.; Similarity: belongs to the sugar transporter family.; Title: strong similarity to high affinity glucose transporter HGT1 - Kluyveromyces lactis; plasma membrane; See PMID 8830679; uncharacterized protein 677188 4987130 An14g02740 Aspergillus niger uncharacterized protein XP_001400900.1 675426 D 5061 CDS An14g02750 4987131 join(678710..678784,678820..679033,679103..679201,679232..679276,679393..679499,679583..680267,680319..681154) I 1 NT_166529.1 Function: in spite of the strong similarity to ABC transporters, these proteins are located in the cytoplasm,where they associate with the ribosomal fraction; their are involved in the control of translation via direct or indirect regulation of elongation factor eIF2.; Similarity: the predicted ORF shows strong similarity to many members of the ABC transporter family; nevertheless, its closer homologues are GCN20 of S. cerevisiae and the mammalian counterparts ABC50 of H. sapiens and R. norvegicus.; Title: strong similarity to protein Gcn20 -Saccharomyces cerevisiae; cytoplasm; See PMID 9020838; See PMID 9234705; See PMID 9790762; See PMID 10931828; See PMID 7621831; uncharacterized protein 681154 4987131 An14g02750 Aspergillus niger uncharacterized protein XP_059604628.1 678710 D 5061 CDS An14g02760 4987132 complement(join(682273..682352,682419..682651,682702..683108)) I 1 NT_166529.1 Catalytic activity: endohydrolysis of 1,4-beta-d-glucosidic linkages in cellulose.; Function: eglA has carboxylmethylcellulase activity.; Gene-ID: eglA; Induction: transcription of eglA is induced by the transcription factor XlnR.; Remark: A. niger eglA has been patented under patentnumber WO9713853-A2.; Similarity: eglA belongs to cellulase family h (family 12 of glycosyl hydrolases).; See PMID 9758775; endoglucanase A eglA-Aspergillus niger 683108 eglA 4987132 eglA Aspergillus niger endoglucanase A eglA-Aspergillus niger XP_001400902.1 682273 R 5061 CDS An14g02770 84592952 complement(join(684774..684974,685036..685479)) I 1 NT_166529.1 Title: weak similarity to hypothetical Stig1 -Petunia hybrida; uncharacterized protein 685479 84592952 An14g02770 Aspergillus niger uncharacterized protein XP_059604629.1 684774 R 5061 CDS An14g02780 4987134 join(686470..686636,686689..687490,687541..687601,687649..687834,687962..688371) I 1 NT_166529.1 Function: the UaY gene codes for a transcriptional activator mediating the induction of a number of unlinked genes involved in purine utilization in Aspergillus nidulans.; Similarity: the N-terminal region of the predicted ORF contains a fungal Zn(2)-Cys(6) binuclear cluster domain, a cysteine-rich region that binds DNA, and is found in many fungal transcriptional activators.; Title: similarity to positive regulator of purine utilisation uaY - Aspergillus nidulans; nucleus; See PMID 7729421; uncharacterized protein 688371 4987134 An14g02780 Aspergillus niger uncharacterized protein XP_059604630.1 686470 D 5061 CDS An14g02790 4987135 complement(join(688830..690570,690604..690770)) I 1 NT_166529.1 Title: weak similarity to hypothetical 2,3-cyclic-nucleotide 3-phosphodiesterase related protein -Neurospora crassa; uncharacterized protein 690770 4987135 An14g02790 Aspergillus niger uncharacterized protein XP_059604631.1 688830 R 5061 CDS An14g02810 84592953 complement(join(694506..695191,695289..695295)) I 1 NT_166529.1 hypothetical protein 695295 84592953 An14g02810 Aspergillus niger hypothetical protein XP_059602300.1 694506 R 5061 CDS An14g02820 84592954 complement(join(696276..696395,696539..696916)) I 1 NT_166529.1 hypothetical protein 696916 84592954 An14g02820 Aspergillus niger hypothetical protein XP_059602301.1 696276 R 5061 CDS An14g02830 4987139 join(698112..698289,698402..698595,698705..698761,698854..699654) I 1 NT_166529.1 Similarity: the predicted A. niger ORF shows similarity to several different dehydrogenases.; Title: weak similarity to norsolorinic acid reductase norA - Aspergillus parasiticus; See PMID 8593042; uncharacterized protein 699654 4987139 An14g02830 Aspergillus niger uncharacterized protein XP_001400908.3 698112 D 5061 CDS An14g02840 4987140 complement(join(700172..700542,700613..700754)) I 1 NT_166529.1 Title: similarity to hypothetical protein EAA58614.1 - Aspergillus nidulans; uncharacterized protein 700754 4987140 An14g02840 Aspergillus niger uncharacterized protein XP_001400909.1 700172 R 5061 CDS An14g02850 4987141 join(701296..701604,701693..701732,701781..701833) I 1 NT_166529.1 Remark: blastp shows significant similarity (52% positives) between the predicted A. niger protein and R. erythropolis ORF4 but due to shortness of both peptides the calculated probability is low (p=0,002).; Title: similarity to hypothetical protein ORF4 -Rhodococcus erythropolis; uncharacterized protein 701833 4987141 An14g02850 Aspergillus niger uncharacterized protein XP_001400910.3 701296 D 5061 CDS An14g02860 4987142 join(702261..702632,702729..702973,703062..703833) I 1 NT_166529.1 Catalytic activity: Atrazine chlorohydrolases convert Atrazine + H(2)O to 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + chloride.; Function: Pseudomonas AtzA catalyzes the dechlorination of atrazine, simazine, and desethylatrazine but is not active with melamine, terbutylazine, or desethyldesisopropylatrazine.; Remark: EC 3. 8. 1. 8; Title: strong similarity to atrazine chlorohydrolase atzA - Pseudomonas sp.; See PMID 8759853; uncharacterized protein 703833 4987142 An14g02860 Aspergillus niger uncharacterized protein XP_001400911.1 702261 D 5061 CDS An14g02870 4987143 complement(join(703872..704495,704541..705320,705372..705389)) I 1 NT_166529.1 Catalytic activity: Succinate-semialdehyde dehydrogenases convert Succinate semialdehyde + NAD(P)(+) + H(2)O to succinate + NAD(P)H.; Function: in E. coli gabD is required for the utilisation of 4-hydroxyphenylacetate as nitrogene source.; Function: in higher eucaryotes Succinate-semialdehyde dehydrogenases are required for the catabolism of GABA intermediates.; Function: mutations of Succinate-semialdehyde dehydrogenases in higher eucaryotes give rise to central nervous system dysfunction.; Title: strong similarity to succinate-semialdehyde dehydrogenase gabD - Escherichia coli; See PMID 2254272; See PMID 6756331; See PMID 8412016; uncharacterized protein 705389 4987143 An14g02870 Aspergillus niger uncharacterized protein XP_001400912.1 703872 R 5061 CDS An14g02880 4987144 join(707201..707374,707422..707442,707490..708860) I 1 NT_166529.1 Function: S. cerevisiae Mal31 is a high-affinity maltose transporter.; Title: strong similarity to maltose transport protein Mal31 - Saccharomyces cerevisiae; plasma membrane; See PMID 1999393; See PMID 2549370; uncharacterized protein 708860 4987144 An14g02880 Aspergillus niger uncharacterized protein XP_001400913.1 707201 D 5061 CDS An14g02890 4987145 709697..710728 I 1 NT_166529.1 Catalytic activity: S. scrofa LTB4/PGR converts (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)(+) to (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H.; Function: S. scrofa LTB4/PGR is required for the metabolism of the hormones prostaglandin and leukotrien.; Title: strong similarity to 5-oxoprostaglandin 13-reductase LTB4/PGR - Sus scrofa; See PMID 9461497; See PMID 8576264; uncharacterized protein 710728 4987145 An14g02890 Aspergillus niger uncharacterized protein XP_001400914.1 709697 D 5061 CDS An14g02900 4987146 complement(join(710949..712300,712368..712407)) I 1 NT_166529.1 Catalytic activity: Cellobiose dehydrogenases convert Cellobiose + acceptor to cellobiono-1,5-lactone + reduced acceptor.; Function: T. versicolor CDH is required for wood-degradation.; Similarity: T. versicolor CDH is a hemoflavoenzyme.; Title: weak similarity to cellobiose dehydrogenase CDH - Trametes versicolor; See PMID 9573367; uncharacterized protein 712407 4987146 An14g02900 Aspergillus niger uncharacterized protein XP_001400915.1 710949 R 5061 CDS An14g02910 4987147 complement(join(<713416..713603,713657..713874,713926..714444,714495..714772,714820..715182)) I 1 NT_166529.1 Function: Dal5p of S. cerevisiae is a component of the allantoate transport system.; Remark: C-terminally truncated ORF due to contig border.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae [truncated ORF]; See PMID 3275614; See PMID 3294799; See PMID 3301804; uncharacterized protein 715182 4987147 An14g02910 Aspergillus niger uncharacterized protein XP_059604632.1 713416 R 5061 CDS An14g02920 4987148 715704..716801 I 1 NT_166529.1 Title: strong similarity to hypothetical conserved protein yesR - Bacillus subtilis; uncharacterized protein 716801 4987148 An14g02920 Aspergillus niger uncharacterized protein XP_001400917.1 715704 D 5061 CDS An14g02930 84592955 complement(join(718868..719718,720031..720091)) I 1 NT_166529.1 Title: similarity to hypothetical protein encoded by An12g07270 - Aspergillus niger; uncharacterized protein 720091 84592955 An14g02930 Aspergillus niger uncharacterized protein XP_059604633.1 718868 R 5061 CDS An14g02940 4987150 complement(join(720181..721142,721204..721917,721971..722013)) I 1 NT_166529.1 Function: L-sorbose dehydrogenase (SDH) and L-sorbosone dehydrogenase (SNDH) from Gluconobacter oxydans T-100 show an ability to convert D-sorbitol to 2-keto-L-gulonate (2-KLGA).; Function: chemical mutation of the host strain to suppress the L-idonate pathway and replacement of the original promoter with that of E. coli tufB resulted in improving the production of 2-KLGA.; Function: consequently, high-level production from D-sorbitol to 2-KLGA (130 mg/ml) was achieved by simple fermentation of the recombinant Gluconobacter.; Title: strong similarity to FAD dependent L-sorbose dehydrogenase - Gluconobacter oxydans; See PMID 9023923; See PMID 10191408; uncharacterized protein 722013 4987150 An14g02940 Aspergillus niger uncharacterized protein XP_001400919.1 720181 R 5061 CDS An14g02950 4987151 join(723890..723995,724089..724310,724379..724920,724967..725929) I 1 NT_166529.1 Similarity: show strong similarity to several oxidoreductases of different organims.; Title: strong similarity to hypothetical isoamyl alcohol oxidase mreA - Aspergillus oryzae; uncharacterized protein 725929 4987151 An14g02950 Aspergillus niger uncharacterized protein XP_059604634.1 723890 D 5061 CDS An14g02960 84592956 join(727949..728600,728697..728912,728992..729005,729101..729252,729690..729984,730245..730727) I 1 NT_166529.1 Title: similarity to hypothetical protein encoded by An01g14870 - Aspergillus niger; uncharacterized protein 730727 84592956 An14g02960 Aspergillus niger uncharacterized protein XP_059604635.1 727949 D 5061 CDS An14g02970 4987153 join(731209..733902,733960..734715,734767..735093) I 1 NT_166529.1 Similarity: shows strong similarity to sensory transduction histidine kinases and phytochrome-like proteins.; Title: similarity to phytochrome phy - Synechocystis sp.; See PMID 9487803; uncharacterized protein 735093 4987153 An14g02970 Aspergillus niger uncharacterized protein XP_059604636.1 731209 D 5061 CDS An14g02980 4987154 complement(join(735920..737209,737337..737663,737754..737976,738200..738561)) I 1 NT_166529.1 Similarity: similarity results from repetitive sequences.; Title: weak similarity to mucin-like glycoprotein 900 GP900 - Cryptosporidium parvum; uncharacterized protein 738561 4987154 An14g02980 Aspergillus niger uncharacterized protein XP_001400923.3 735920 R 5061 CDS An14g02990 4987155 join(741146..741169,741230..741465,741582..742614) I 1 NT_166529.1 Title: similarity to hypothetical protein KIAA1715 -Homo sapiens; uncharacterized protein 742614 4987155 An14g02990 Aspergillus niger uncharacterized protein XP_059604637.1 741146 D 5061 CDS An14g03000 4987156 complement(join(742918..745411,745468..746360,746418..746547,746596..746743,746850..747102,747162..747185,747276..747304,747378..747465)) I 1 NT_166529.1 Function: CAF of A. thaliana appears to suppress cell division in floral meristems.; Title: similarity to RNA helicase/RNAseIII carpel factory CAF - Arabidopsis thaliana; See PMID 10556049; uncharacterized protein 747465 4987156 An14g03000 Aspergillus niger uncharacterized protein XP_059604638.1 742918 R 5061 CDS An14g03010 4987157 complement(join(748517..749020,749074..749330,749528..749543,749822..749875)) I 1 NT_166529.1 Function: might be involved in transcriptional regulation.; Similarity: shows similarity to proteins containing bZIP transcription factor domains.; Title: weak similarity to transcription activator Cin5 - Saccharomyces cerevisiae; uncharacterized protein 749875 4987157 An14g03010 Aspergillus niger uncharacterized protein XP_059604639.1 748517 R 5061 CDS An14g03020 4987158 complement(join(751710..752960,753010..753441,753507..753795,753866..754022,754092..754176)) I 1 NT_166529.1 Function: suggested activities include nutritional activity, cytokine and cell proliferation/differentiation activity, immune stimulating (e. g. as vaccines) or suppressing activity, haematopoiesis regulating activity,tissue growth activity, activin/inhibin activity,chemotactic/chemokinetic activity, haemostatic and thrombolytic activity, receptor/ligand activity,anti-inflammatory activity, cadherin/tumour invasion suppressor activity, and tumour inhibition activity.; Function: the human secreted proteins, and the polynucleotides encoding them, are predicted to have biological activities which would make them suitable for treating, preventing or ameliorating medical conditions in humans and animals.; Remark: blast hit against protein of patent database.; Title: similarity to secreted protein SEQ ID NO:58 from patent WO9957132-A1 - Homo sapiens; uncharacterized protein 754176 4987158 An14g03020 Aspergillus niger uncharacterized protein XP_001400927.1 751710 R 5061 CDS An14g03030 4987159 complement(<754801..755374) I 1 NT_166529.1 Catalytic activity: it catalyzes the N(1)-acetylation of spermidine and spermine and, by the successive activity of polyamine oxidase, spermine can be converted to spermidine and spermidine to putrescine.; Function: human SPD/SPM acetyltransferase is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism.; Remark: contains putative sequencing error that caused a wrong geneprediction (wrong start codon).; Similarity: shows similarity to several acetyltransferases of different species.; Title: similarity to spermidine/spermine N(1)-acetyltransferase SAT - Homo sapiens [putative frameshift]; putative frameshift; See PMID 1985966; uncharacterized protein 755374 4987159 An14g03030 Aspergillus niger uncharacterized protein XP_001400928.3 754801 R 5061 CDS An14g03040 4987160 complement(join(755904..757380,757463..758804,759043..759481,759615..759746)) I 1 NT_166529.1 Similarity: shows similarity to myosin heavy chain of different species.; Title: similarity to myosin heavy chain -Dictyostelium discoideum; See PMID 2828113; See PMID 3540939; See PMID 3901008; uncharacterized protein 759746 4987160 An14g03040 Aspergillus niger uncharacterized protein XP_059604640.1 755904 R 5061 CDS An14g03050 4987161 join(761089..761450,761558..762207,762355..765791) I 1 NT_166529.1 Similarity: shows weak similarities to neuropathy target esterases.; Title: strong similarity to hypothetical protein of the UPF0028 family - Schizosaccharomyces pombe; uncharacterized protein 765791 4987161 An14g03050 Aspergillus niger uncharacterized protein XP_059604641.1 761089 D 5061 CDS An14g03060 4987162 join(766892..766961,767021..767120,767188..767754,767818..767887) I 1 NT_166529.1 Title: strong similarity to hypothetical protein encoded by An16g01890 - Aspergillus niger; uncharacterized protein 767887 4987162 An14g03060 Aspergillus niger uncharacterized protein XP_001400931.3 766892 D 5061 CDS An14g03070 4987163 join(768815..769406,769465..770474) I 1 NT_166529.1 Catalytic activity: CHO has oligosaccharide oxidation activity.; Function: it can oxidize the reducing end of an oligosaccharide more efficiently than the corresponding monosaccharide, e. g. preferentially oxidizing maltodextrins or cellodextrins over glucose.; Similarity: shows strong similarity to several oxidases with unknown function and to M. nivale carbohydrate oxidase (CHO) i. e. protein Y24919 of patent WO9931990-A1.; Title: strong similarity to carbohydrate oxidase CHO from patent WO9931990-A1 - Microdochium nivale; uncharacterized protein 770474 4987163 An14g03070 Aspergillus niger uncharacterized protein XP_001400932.1 768815 D 5061 CDS An14g03080 4987164 complement(join(771951..772209,772273..772376,772438..772581)) I 1 NT_166529.1 Localization: might be a transmembrane protein.; Similarity: seems to be the aminoterminus of the predicted protein.; Similarity: shows strong similarity to pos. 121 to 553 of cDNA clone 2960 of A. niger.; Similarity: the ORF shows strong similarity to cDNA clone 2960 - Aspergillus niger.; Title: similarity to hypothetical membrane protein YDL218w - Saccharomyces cerevisiae; uncharacterized protein 772581 4987164 An14g03080 Aspergillus niger uncharacterized protein XP_001400933.1 771951 R 5061 CDS An14g03090 4987165 complement(join(776697..776835,776918..777146,777205..777345,777405..777667,777727..778049,778112..778126,778194..778391)) I 1 NT_166529.1 Title: strong similarity to glucose/galactose transporter gluP - Brucella abortus; See PMID 9168605; uncharacterized protein 778391 4987165 An14g03090 Aspergillus niger uncharacterized protein XP_001400934.1 776697 R 5061 CDS An14g03100 4987166 complement(join(779172..779916,779990..780558)) I 1 NT_166529.1 Function: chicken enzyme is responsible for the formation of pentaantennary asparagine-linked oligosaccharides (N-glycans).; Similarity: shows only similarity to aminoterminal part of chicken enzyme and similiar enzymes of other species.; Title: weak similarity to N-acetylglucosaminyltransferase VI GnT-VI - Gallus gallus; See PMID 10962001; uncharacterized protein 780558 4987166 An14g03100 Aspergillus niger uncharacterized protein XP_001400935.1 779172 R 5061 CDS An14g03110 4987167 complement(join(781332..782144,782194..782407,782453..782783,782830..783037)) I 1 NT_166529.1 Function: initial oxygenation step in trichothecene toxin biosynthesis.; Remark: trichothecenes are sesquiterpenoid mycotoxins and act as protein synthesis inhibitors for eukaryotic organisms.; Title: strong similarity to cytochrome P450 monooxygenase TRI4 - Myrothecium roridum; See PMID 7651333; See PMID 9529523; uncharacterized protein 783037 4987167 An14g03110 Aspergillus niger uncharacterized protein XP_001400936.1 781332 R 5061 CDS An14g03120 4987168 join(783399..783551,783604..783744,783793..784122,784174..784241,784291..784370,784451..784779) I 1 NT_166529.1 Similarity: shows only similarity to the central part of pth11.; Title: weak similarity to integral membrane protein PTH11 from patent WO9913094-A2 - Magnaporthe grisea; uncharacterized protein 784779 4987168 An14g03120 Aspergillus niger uncharacterized protein XP_059604642.1 783399 D 5061 CDS An14g03130 84592957 complement(join(786324..786478,786534..786597)) I 1 NT_166529.1 hypothetical protein 786597 84592957 An14g03130 Aspergillus niger hypothetical protein XP_059604643.1 786324 R 5061 CDS An14g03140 4987170 complement(join(788061..788093,788157..788933,788987..789927,789980..790300,790368..790551)) I 1 NT_166529.1 Function: sporulation and tetrad analysis revealed that deletion of YNL059c/ARP5 was lethal for vegetative growth in strain W303 and caused severe growth defects in strain FY1679.; Title: strong similarity to nuclear protein YNL059c - Saccharomyces cerevisiae; nucleus; See PMID 10923024; uncharacterized protein 790551 4987170 An14g03140 Aspergillus niger uncharacterized protein XP_001400939.1 788061 R 5061 CDS An14g03150 4987171 complement(join(791015..791061,791109..791193,791248..791271)) I 1 NT_166529.1 hypothetical protein 791271 4987171 An14g03150 Aspergillus niger hypothetical protein XP_001400940.3 791015 R 5061 CDS An14g03160 4987172 join(791899..792385,792536..792576) I 1 NT_166529.1 Title: weak similarity to hypothetical protein CAE02259.1 - Oryza sativa; uncharacterized protein 792576 4987172 An14g03160 Aspergillus niger uncharacterized protein XP_001400941.3 791899 D 5061 CDS An14g03170 10098178 join(793554..793689,793884..793996) I 1 NT_166529.1 hypothetical protein 793996 10098178 An14g03170 Aspergillus niger hypothetical protein XP_059604644.1 793554 D 5061 CDS An14g03180 4987174 complement(join(795081..795212,795286..795420,795519..795603,795692..795707,795808..795835)) I 1 NT_166529.1 Function: Cdc3-profilin may play an essential role in cytokinesis by catalyzing the formation of the F-actin contractile ring.; Function: in S. pombe, cdc3-124 mutant is defective for cytokinesis, but not for DNA replication, mitosis, or septum synthesis.; Function: profilin is an actin-monomer-binding protein.; Title: strong similarity to profilin cdc3p -Schizosaccharomyces pombe; cytoskeleton; uncharacterized protein 795835 4987174 An14g03180 Aspergillus niger uncharacterized protein XP_001400943.1 795081 R 5061 CDS An14g03190 4987175 join(798126..798998,799059..799886) I 1 NT_166529.1 Remark: only repetitive elements are matching.; Title: weak similarity to hypothetical protein EG:56G7.1 - Drosophila melanogaster; uncharacterized protein 799886 4987175 An14g03190 Aspergillus niger uncharacterized protein XP_001400944.1 798126 D 5061 CDS An14g03200 4987176 complement(800349..806324) I 1 NT_166529.1 Remark: the ORF is transcribed in vegetative cells but it is not essential for viability as demonstrated by gene disruption.; Similarity: homologous to RNA-helicase SKI2 S. cerevisiae.; Title: strong similarity to hypothetical RNA-helicase G9365 - Saccharomyces cerevisiae; See PMID 9133744; uncharacterized protein 806324 4987176 An14g03200 Aspergillus niger uncharacterized protein XP_001400945.1 800349 R 5061 CDS An14g03210 4987177 complement(807564..808568) I 1 NT_166529.1 Remark: strong similarity to human transcriptional regulator protein #28 patent WO200078954-A2.; Title: strong similarity to transcriptional regulator protein #28 TXREG from patent WO200078954-A2 -Homo sapiens; uncharacterized protein 808568 4987177 An14g03210 Aspergillus niger uncharacterized protein XP_001400946.1 807564 R 5061 CDS An14g03220 4987178 808814..809740 I 1 NT_166529.1 Similarity: the ORF shows similarity to some putative DNA-J-like chaperones/heat shock proteins.; Title: similarity to hypothetical DNA-J-like protein SPAC4G9.19 - Schizosaccharomyces pombe; uncharacterized protein 809740 4987178 An14g03220 Aspergillus niger uncharacterized protein XP_001400947.1 808814 D 5061 CDS An14g03230 4987179 join(810296..810865,811014..811067,811102..811409,811476..812450,812489..812600,812654..812722,812756..812857) I 1 NT_166529.1 Title: weak similarity to hypothetical protein encoded by An13g03440 - Aspergillus niger; uncharacterized protein 812857 4987179 An14g03230 Aspergillus niger uncharacterized protein XP_059604645.1 810296 D 5061 CDS An14g03240 4987180 complement(join(813848..814863,814926..815247)) I 1 NT_166529.1 Catalytic activity: acyl-CoA + NADP+ = 2,3-dehydroacyl-CoA + NADPH.; Remark: is a medium chain acyl-CoA dehydrogenase (MCADH). the active site glutamic acid of the protein does not lie in the same position as other well characterized MCADH, but in a position present in long chain and isovaleryl acyl-CoA dehydrogenases (LCADH and IVDH).; Similarity: belongs to the acyl-CoA dehydrogenase family.; Title: strong similarity to acyl-CoA dehydrogenase (NADP+) ACDH - Mycobacterium tuberculosis; See PMID 9535763; uncharacterized protein 815247 4987180 An14g03240 Aspergillus niger uncharacterized protein XP_001400949.1 813848 R 5061 CDS An14g03250 4987181 complement(815546..816385) I 1 NT_166529.1 Catalytic activity: preverential cleavage in B chain of insulin: Asn3-|-Gln,Gly13-|-Ala, Tyr26-|-Thr.; Remark: alternate name is proteinase A.; Remark: proteinase A obtained from the culture medium of Aspergillus niger var. macrosporus is a unique acid endopeptidase that is insensitive (or less sensitive) to specific inhibitors of ordinary acid or aspartic proteinases, such as pepstatin, diazoacetyl-DL-norleucine methyl ester, and 1,2-epoxy-3-(p-nitrophenoxy)-propane.; Similarity: belongs to peptidase family a4.; Title: strong similarity to aspergillopepsin II -Aspergillus niger; extracellular/secretion proteins; See PMID 1918059; See PMID 1918060; uncharacterized protein 816385 4987181 An14g03250 Aspergillus niger uncharacterized protein XP_001400950.1 815546 R 5061 CDS An14g03260 84592958 complement(join(816785..816981,817089..817326)) I 1 NT_166529.1 hypothetical protein 817326 84592958 An14g03260 Aspergillus niger hypothetical protein XP_059604646.1 816785 R 5061 CDS An14g03270 4987183 complement(join(818081..818277,818347..819214)) I 1 NT_166529.1 Title: strong similarity to hypothetical SAM-dependent methyltransferase YOR240w - Saccharomyces cerevisiae; uncharacterized protein 819214 4987183 An14g03270 Aspergillus niger uncharacterized protein XP_059604647.1 818081 R 5061 CDS An14g03280 4987184 complement(join(819721..819769,819862..820180,820257..821662,821744..821817)) I 1 NT_166529.1 Catalytic activity: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O.; Pathway: fourth step in valine and isoleucine biosynthesis. valine, leucine and isoleucine biosynthesis; pantothenate and CoA biosynthesis.; Remark: the biosynthesis of branched-chain amino acids (aa) involves three shared pathways through which pyruvate or alpha-ketobutyrate are converted into alpha-keto acids, precursors of valine, leucine or isoleucine.; Similarity: belongs to the dihydroxyacid dehydratase/phosphogluconate dehydratases.; Title: strong similarity to dihydroxy-acid dehydratase Ilv3 - Saccharomyces cerevisiae; See PMID 8299945; uncharacterized protein 821817 4987184 An14g03280 Aspergillus niger uncharacterized protein XP_001400953.1 819721 R 5061 CDS An14g03290 4987185 join(822879..823214,823275..825788,825837..827663) I 1 NT_166529.1 Remark: ATP-dependent bile acid transport was abolished when the BAT1 coding region was deleted from the genome and restored upon reintroduction of the gene.; Remark: ATP-dependent transport of bile acids is a key determinant of bile flow in mammalian liver and is associated with cholesterol excretion, gallstone formation,and numerous inherited and acquired hepatobiliary diseases. Secretory vesicles and a vacuole enriched fraction purified from S. cerevisiae also exhibit ATP-dependent bile acid transport.; Remark: alternative names are YLL048c, BAT1.; Similarity: to ABC-type multidrug/protein/lipid transport system, ATPase component.; Title: strong similarity to bile acid transporter Ybt1 - Saccharomyces cerevisiae; See PMID 9020838; See PMID 9182565; uncharacterized protein 827663 4987185 An14g03290 Aspergillus niger uncharacterized protein XP_001400954.3 822879 D 5061 CDS An14g03300 4987186 join(827810..827919,827972..828342,828406..829190) I 1 NT_166529.1 Title: weak similarity to hypothetical protein BAB32722.1 - Oryza sativa; uncharacterized protein 829190 4987186 An14g03300 Aspergillus niger uncharacterized protein XP_059604648.1 827810 D 5061 CDS An14g03310 4987187 complement(join(829996..830278,830351..830748,830807..831190)) I 1 NT_166529.1 Catalytic activity: D-amino acid + H2O + O2 = 2-oxo acid + NH3 + H2O2.; Pathway: glycine, serine and threonine metabolism; arginine and proline metabolism; D-arginine and D-ornithine metabolism.; Remark: strong similarity to D-amino acid oxidase DAO1 patent EP0969088-A/2 from Trigonopsis variabilis.; Remark: the patent is the dao gene with an addition in 5 of a nucleotide coding for a polyhistidine of 6 (hisDAO; Remark: the three C-terminal amino acids of the DAO1 gene of Trigonopsis variabilis encoding a D-amino acid oxidase suggest that the enzyme may be located in peroxisomes.; Similarity: belongs to the DAMOX/DASOX family.; Title: strong similarity to D-amino acid oxidase DAO1 from patent EP0969088-A - Trigonopsis variabilis; See PMID 9434346; uncharacterized protein 831190 4987187 An14g03310 Aspergillus niger uncharacterized protein XP_001400956.1 829996 R 5061 CDS An14g03320 84592959 join(831276..831355,831467..831580,831675..831867,831918..831998,832131..832346,832436..832593,832653..832880,833120..833162) I 1 NT_166529.1 Title: weak similarity to hypothetical protein 68B2.60 - Neurospora crassa; uncharacterized protein 833162 84592959 An14g03320 Aspergillus niger uncharacterized protein XP_059604649.1 831276 D 5061 CDS An14g03330 4987189 complement(join(833967..835057,835130..835346)) I 1 NT_166529.1 Title: similarity to hypothetical protein SCF12.05 -Streptomyces coelicolor; uncharacterized protein 835346 4987189 An14g03330 Aspergillus niger uncharacterized protein XP_001400958.1 833967 R 5061 CDS An14g03340 4987190 complement(join(835864..836752,836809..836966,837049..837203,837255..837399,837456..837566,837624..837865,837957..838065)) I 1 NT_166529.1 Remark: expression analysis of tfdB (1,2-dichlorophenol hydroxylase (DCPH))and tfdC in Escherichia coli suggested that these genes form one operon, tfdCB.; Title: strong similarity to 1,2-dichlorophenol hydroxylase tfdB - Pseudomonas putida; See PMID 8890750; uncharacterized protein 838065 4987190 An14g03340 Aspergillus niger uncharacterized protein XP_001400959.1 835864 R 5061 CDS An14g03350 84592960 join(838519..838576,838821..839096,839276..839334) I 1 NT_166529.1 Remark: weak similarity to fragment of human secreted protein encoded by gene 92 patent WO9947540-A1.; Title: weak similarity to fragment of secreted protein encoded by gene 92 from patent WO9947540-A1 - Homo sapiens; uncharacterized protein 839334 84592960 An14g03350 Aspergillus niger uncharacterized protein XP_059604650.1 838519 D 5061 CDS An14g03360 4987192 839669..841804 I 1 NT_166529.1 Remark: gene disruption experiments showed that SCT1 is not an essential gene under the standard culture conditions. SCT1 did not suppress a null mutant of ctr1,indicating that a mutant form of choline transporter is necessary for the suppression caused by SCT1.; Title: strong similarity to choline-transport mutant SCT1 supressor protein - Saccharomyces cerevisiae; See PMID 7603986; See PMID 7608137; uncharacterized protein 841804 4987192 An14g03360 Aspergillus niger uncharacterized protein XP_001400961.1 839669 D 5061 CDS An14g03370 4987193 complement(join(843093..843418,843443..843518,843570..844106,844164..844661)) I 1 NT_166529.1 Catalytic activity: allantoin + H2O = allantoate.; Function: utilization of purines as secondary nitrogen sources, when primary sources are limiting.; Pathway: first step in the degradation of allantoin (purine catabolism).; Remark: DAL1 is expressed in an inducer-independent manner in strain M970 (sigma 1278b genetic background) and modestly responds to mutation of the dal80 locus. Expression was also sensitive to nitrogen catabolite repression (NCR).; Similarity: belongs to the DHOASE family.; Title: strong similarity to allantoinase Dal1 -Saccharomyces cerevisiae; See PMID 1803816; uncharacterized protein 844661 4987193 An14g03370 Aspergillus niger uncharacterized protein XP_059604651.1 843093 R 5061 CDS An14g03380 84592961 join(845301..845383,845477..845528,845616..845752,845869..845949,846042..846147) I 1 NT_166529.1 hypothetical protein 846147 84592961 An14g03380 Aspergillus niger hypothetical protein XP_059604652.1 845301 D 5061 CDS An14g03390 4987195 join(848134..849264,849321..850569,850632..850861) I 1 NT_166529.1 Remark: FluG from E. nidulans has no apparent role in glutamine biosynthesis, but has an enzymatic role in sporulation factor production.; Remark: interaction between fluG and veA influences the production of the extracellular signal and regulates the initiation of conidiation.; Remark: mutations in the Aspergillus nidulans fluG gene disrupt the programmed induction of asexual sporulation and result in formation of fluffy colonies that are characterized by undifferentiated cotton-like masses of vegetative cells.; Similarity: to glutamate-ammonia ligases.; Title: strong similarity to fluG - Aspergillus nidulans; See PMID 7926755; See PMID 8617205; See PMID 9691036; See PMID 11454752; uncharacterized protein 850861 4987195 An14g03390 Aspergillus niger uncharacterized protein XP_001400964.1 848134 D 5061 CDS An14g03400 4987196 851178..852293 I 1 NT_166529.1 Catalytic activity: carbamoyl phosphate + L-ornithine = orthophosphate + L-citrulline.; Gene-ID: argB; Mapping: argB from A. niger is mapped to chromosome I; see list from DSM.; Pathway: urea cycle and metabolism of amino groups; arginine and proline metabolism.; Remark: putative sequencing error at positions 56475, 56488 and 56513 generating Frame shifts.; Remark: the N terminus, which shows little or no homology to other OCTases, is highly basic and is probably involved in mitochondrial targeting.; Remark: the differences in the sequence are caused by strain variations or sequencing errors.; Similarity: belongs to the OCTase family.; localisation:mitochondrion; See PMID 3443301; ornithine carbamoyltransferase argB-Aspergillus niger [putative sequencing error] 852293 argB 4987196 argB Aspergillus niger ornithine carbamoyltransferase argB-Aspergillus niger [putative sequencing error] XP_001400965.1 851178 D 5061 CDS An14g03410 4987197 complement(join(852776..853465,853522..853902)) I 1 NT_166529.1 Remark: also strong similarity with EST an_3520 Aspergillus niger.; Remark: strong similarity to the 3'-untranslated region of the A. niger argB gene encoding ornithine carbamoyl transferase.; Remark: the corresponding gene in potato is of low copy number, is expressed in a variety of tissues, and encodes a protein which includes several domains with similarity to database sequences, including ferredoxin from Clostridium pasteurianum. Expression of the cDNA in E. coli yields a fusion protein with sucrolytic activity.; Title: similarity to sucrose cleavage protein -Solanum tuberosum; See PMID 7957893; uncharacterized protein 853902 4987197 An14g03410 Aspergillus niger uncharacterized protein XP_001400966.1 852776 R 5061 CDS An14g03420 4987198 complement(join(854748..855269,855325..855705,855799..855839,855892..855946)) I 1 NT_166529.1 Remark: proteins containing C-terminal 'CAAX' sequence motifs undergo three sequential post-translational processing steps: modification of the cysteine with either a 15-carbon farnesyl or 20-carbon geranylgeranyl isoprenyl lipid, proteolysis of the C-terminal -AAX tripeptide, and methylation of the carboxyl group of the now C-terminal prenylcysteine.; Remark: the human RCE1 gene product is bona fide a prenyl protein protease and play a major role in the processing of CAAX-type prenylated proteins.; Title: strong similarity to CAAX prenyl protein protease RCE1 - Homo sapiens; See PMID 10085068; uncharacterized protein 855946 4987198 An14g03420 Aspergillus niger uncharacterized protein XP_001400967.1 854748 R 5061 CDS An14g03430 4987199 join(857124..857417,857469..857479,857527..857779,857833..859137) I 1 NT_166529.1 Remark: aflatoxins are polyketide-derived secondary metabolites.; Remark: northern blot analysis and reverse transcriptase-polymerase chain reaction (RT-PCR) studies demonstrated that the gene moxY, is expressed concurrently with genes involved in aflatoxin biosynthesis. Therefore,the two putative aflatoxin pathway genes cypX and moxY followed by a 5-kb non-coding region of DNA define one end of the boundary of the aflatoxin pathway gene cluster in A. parasiticus.; Similarity: the ORF is longer than moxY of A. parasiticus (620 compared to 481 amino acids).; Title: strong similarity to monooxygenase moxY -Aspergillus parasiticus; See PMID 10855719; uncharacterized protein 859137 4987199 An14g03430 Aspergillus niger uncharacterized protein XP_001400968.1 857124 D 5061 CDS An14g03440 4987200 complement(join(859255..859886,859939..860216,860284..861014)) I 1 NT_166529.1 Remark: cercosporin, a photosensitizing perylenequinone toxin produced by the plant pathogenic Cercospora fungi, generates the highly toxic singlet oxygen (1O2) upon exposure to light. Cercosporin shows broad toxicity against a wide range of organisms, including bacteria, fungi, plants, and animals; however, Cercospora fungi are resistant to its effects.; Remark: targeted disruption of crg1 resulted in mutants that, like CS10, are sensitive to cercosporin. However, unlike CS10, crg1 disruption mutants are not down-regulated in toxin production. Both CS10 and the crg1 disruption mutants are unaffected in their response to other 1O2-generating photosensitizers, suggesting that CRG1 functions specifically against cercosporin, rather than against 1O2.; Title: similarity to cercosporin resistance protein crg1 - Cercospora nicotianae; See PMID 10517336; uncharacterized protein 861014 4987200 An14g03440 Aspergillus niger uncharacterized protein XP_001400969.3 859255 R 5061 CDS An14g03450 4987201 complement(join(861553..862190,862251..862605)) I 1 NT_166529.1 Remark: similarity to human secreted protein, SEQ ID NO: 8103 patent EP1033401-A2.; Similarity: to dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases).; Title: similarity to secreted protein SEQ ID NO:8103 from patent EP1033401-A2 - Homo sapiens; uncharacterized protein 862605 4987201 An14g03450 Aspergillus niger uncharacterized protein XP_001400970.1 861553 R 5061 CDS An14g03460 4987202 complement(join(863259..863321,863372..863465,863506..864095,864161..864686,864743..864867,864927..865037,865097..865273)) I 1 NT_166529.1 Remark: similarity to Leishmania antigen M15 protein patent WO9835045-A2.; Title: similarity to antigen M15 from patent WO9835045-A2 - Leishmania sp.; uncharacterized protein 865273 4987202 An14g03460 Aspergillus niger uncharacterized protein XP_059604653.1 863259 R 5061 CDS An14g03470 4987203 join(865721..865900,865955..866035,866097..867578) I 1 NT_166529.1 Function: antibodies raised against different domains of C-Nap1 from H. sapiens prove that this protein dissociates from spindle poles during mitosis, but reaccumulates at centrosomes at the end of cell division.; Function: the centrosomal protein C-Nap1 from H. sapiens is required for cell cycle-regulated centrosome cohesion.; Localization: antibodies raised against recombinant C-Nap1 from H. sapiens produced strong labeling of centrosomes by immunofluorescence, and immunoelectron microscope revealed that C-Nap1 is associated specifically with the proximal ends of both mother and daughter centrioles.; Phenotype: antibody-mediated interference with C-Nap1 from H. sapiens function causes centrosome splitting, regardless of the cell cycle phase.; Remark: human C-Nap1 was first identified as a human Nek2-interacting protein in a yeast two-hybrid screen.; Title: similarity to centrosomal Nek2-associated protein C-NAP1 - Homo sapiens; nucleus; See PMID 9647649; See PMID 11076968; uncharacterized protein 867578 4987203 An14g03470 Aspergillus niger uncharacterized protein XP_001400972.1 865721 D 5061 CDS An14g03480 84592962 complement(join(867732..867837,867916..868248,868341..868492)) I 1 NT_166529.1 hypothetical protein 868492 84592962 An14g03480 Aspergillus niger hypothetical protein XP_059604654.1 867732 R 5061 CDS An14g03490 84592963 join(868676..869373,869435..869567,869617..870063) I 1 NT_166529.1 Title: weak similarity to Son of sevenless protein Sos from patent WO200005258-A1 - Drosophila melanogaster; uncharacterized protein 870063 84592963 An14g03490 Aspergillus niger uncharacterized protein XP_059604655.1 868676 D 5061 CDS An14g03500 4987206 complement(join(870823..871695,871757..872864,872923..873068)) I 1 NT_166529.1 Catalytic activity: D-Xylulose 5-phosphate + Formaldehyde = Glyceraldehyde 3-phosphate + Glycerone.; Cofactor: Thiamine diphosphate.; Phenotype: a das1 deletion strain of C. boidinii has completely lost the ability to grow on methanol,; Title: strong similarity to dihydroxyacetone synthase DAS1 - Candida boidinii; peroxisome; See PMID 9811645; uncharacterized protein 873068 4987206 An14g03500 Aspergillus niger uncharacterized protein XP_001400975.1 870823 R 5061 CDS An14g03510 4987207 join(873593..873798,873854..873981,874035..874194,874253..874721,874776..874979) I 1 NT_166529.1 Catalytic activity: L-iditol + NAD(+) = L-sorbose + NADH.; Pathway: the rat Sorbitol dehydrogenase SDH is involved in the fructose and mannose metabolism.; Remark: two isoforms of SDH from R. norvegicus are produced by use of alternative initiation codons in the same reading frame.; Title: strong similarity to sorbitol dehydrogenase SDH - Rattus norvegicus; See PMID 8223590; See PMID 8761460; uncharacterized protein 874979 4987207 An14g03510 Aspergillus niger uncharacterized protein XP_001400976.1 873593 D 5061 CDS An14g03520 4987208 join(877110..877209,877414..877658,877729..878178,878242..878820) I 1 NT_166529.1 Function: Dfg5 from S. cerevisiae is required for filamentous growth, cell polarity, and cellular elongation.; Phenotype: a dfg5 mutant of S. cerevisiae blocks filamentous growth.; Remark: the synonym for Dfg5 from S. cerevisiae is YMR238w.; Title: strong similarity to filamentous growth protein Dfg5 - Saccharomyces cerevisiae; See PMID 9055077; uncharacterized protein 878820 4987208 An14g03520 Aspergillus niger uncharacterized protein XP_001400977.1 877110 D 5061 CDS An14g03530 4987209 complement(join(880246..880655,880729..880793,880858..881231,881383..881673)) I 1 NT_166529.1 Function: Pth11 of M. grisea is involved in host surface recognition but is not required for appressorium morphogenesis.; Function: Pth11 of M. grisea is involved in the response to both host cutin monomers and contact surface hydrophobicity.; Localization: a M. grisea Pth11-green fluorescent protein fusion was localized to the cell membrane and vacuoles.; Phenotype: pth11 mutants of the M. grisea strain 4091-5-8 are nonpathogenic due to a defect in appressorium differentiation.; Title: similarity to integral membrane protein PTH11 from patent WO9913094-A2 - Magnaporthe grisea; plasma membrane; See PMID 10521529; uncharacterized protein 881673 4987209 An14g03530 Aspergillus niger uncharacterized protein XP_059604656.1 880246 R 5061 CDS An14g03540 4987210 join(882491..882768,882863..884615) I 1 NT_166529.1 Title: similarity to hypothetical protein encoded by An08g01290 - Aspergillus niger; uncharacterized protein 884615 4987210 An14g03540 Aspergillus niger uncharacterized protein XP_059604657.1 882491 D 5061 CDS An14g03550 4987211 complement(join(884769..884912,885004..885474,885540..886062,886112..886236,886286..886510)) I 1 NT_166529.1 Phenotype: the dal5 deletion mutant of S. cerevisiae is viable but unable to transport allontoate or ureidosuccinate.; Remark: synonyms for Dal5 from S. cerevisiae are Urep1 and YJR152w.; Repression: DAL5 is constitutively expressed in S. cerevisiae but DAL5 mRNA levels dropped precipitously when a repressive nitrogen source was provided.; Similarity: S. cerevisiae DAL5 specifies the Dal5p subfamily of the major facilitator family, which also includes YGR260w and YLR004c.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; cytoplasm; See PMID 3294799; See PMID 3301804; See PMID 3549700; uncharacterized protein 886510 4987211 An14g03550 Aspergillus niger uncharacterized protein XP_059604658.1 884769 R 5061 CDS An14g03560 4987212 887097..888359 I 1 NT_166529.1 Catalytic activity: hydrolysis of Xaa-|-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs; no action on Pro-|-Pro.; Cofactor: Manganese.; Remark: Microbacterium esteraromaticum = Aureobacterium esteraromaticum.; Remark: the best substrate for the prolidase from A. esteraromaticum is Pro-Hyp.; Title: strong similarity to prolidase -Aureobacterium esteraromaticum; See PMID 9989239; uncharacterized protein 888359 4987212 An14g03560 Aspergillus niger uncharacterized protein XP_001400981.1 887097 D 5061 CDS An14g03570 4987213 join(890124..891216,891276..891958,892006..894528) I 1 NT_166529.1 Function: AtrB from A. nidulans is a multidrug ABC transporter and has affinity to substrates belonging to all major classes of agricultural fungicides and some natural toxic compounds.; Function: AtrB of A. nidulans acts by preventing intracellular accumulation of the toxicant.; Function: cDNA of atrB from A. nidulans can complement the drug hypersensitivity associated with PDR5 deficiency in S. cerevisiae.; Induction: The transcription of atrB in mycelium of A. nidulans is strongly enhanced by treatment with several drugs, including antibiotics, azole fungicides and plant defense toxins.; Phenotype: atrB deletion mutants of A. nidulans displayed increased sensitivity to anilinopyrimidine,benzimidazole, phenylpyrrole, phenylpyridylamine,strobirulin and some azole fungicides.; Remark: Emericella nidulans = Aspergillus nidulans.; Title: strong similarity to ATP-binding cassette multidrug transport protein atrB - Aspergillus nidulans; plasma membrane; See PMID 9180695; See PMID 10931903; uncharacterized protein 894528 4987213 An14g03570 Aspergillus niger uncharacterized protein XP_001400982.1 890124 D 5061 CDS An14g03580 4987214 complement(894954..896270) I 1 NT_166529.1 Remark: the matching coding sequence was isolated by RT-PCR on all of the mRNA from A. thaliana.; Remark: there are no further informations about the patent available.; Title: strong similarity to protein fragment SEQ ID NO:23028 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 896270 4987214 An14g03580 Aspergillus niger uncharacterized protein XP_001400983.1 894954 R 5061 CDS An14g03590 4987215 complement(897084..897872) I 1 NT_166529.1 Function: Nopp 140 functions as a transcriptional activator .; Localization: Nopp140 from R. norvegicus shuttles on tracks between nucleolus and cytoplasm.; Remark: Nopp140 is one of the most phosphorylated proteins in the cell, and nuclear localization signal (NLS) binding of Napp140 was dependent on phosphorylation.; Similarity: the similarities are mainly based on repetetive structures.; Title: similarity to nucleolus-cytoplasm shuttle phosphoprotein Nopp140 - Rattus norvegicus; nucleus; See PMID 8972203; See PMID 1623516; uncharacterized protein 897872 4987215 An14g03590 Aspergillus niger uncharacterized protein XP_001400984.1 897084 R 5061 CDS An14g03600 4987216 complement(join(898247..899210,899269..899822)) I 1 NT_166529.1 Title: similarity to hypothetical protein SPAC56F8.12 - Schizosaccharomyces pombe; uncharacterized protein 899822 4987216 An14g03600 Aspergillus niger uncharacterized protein XP_001400985.1 898247 R 5061 CDS An14g03610 4987217 join(900927..901040,901134..901278,901340..901725,901791..902398,902464..902540,902601..902779) I 1 NT_166529.1 Phenotype: Disruption of TRI11 of F. sporotrichioides results in an altered trichothecene production phenotype characterized by the accumulation of isotrichodermin, a trichothecene pathway intermediate.; Remark: The TRI11 gene of F. sporotrichioides encodes a cytochrome P-450 monooxygenase required for C-15 hydroxylation in trichothecene biosynthesis.; Remark: trichothecenes are sesquiterpenoid mycotoxins and act as protein synthesis inhibitors for eukaryotic organisms; Title: strong similarity to cytochrome P450 monooxygenase TRI11 - Fusarium sporotrichioides [putative sequencing error]; putative sequencing error; See PMID 9435078; uncharacterized protein 902779 4987217 An14g03610 Aspergillus niger uncharacterized protein XP_059604659.1 900927 D 5061 CDS An14g03620 4987218 join(903264..903404,903459..905396) I 1 NT_166529.1 Phenotype: deletion of YJL010C in S. cerevisiae is lethal.; Remark: there are no further informations about the patent available.; Title: strong similarity to essential protein YJL010c from patent WO200039342-A2 - Saccharomyces cerevisiae; uncharacterized protein 905396 4987218 An14g03620 Aspergillus niger uncharacterized protein XP_059604660.1 903264 D 5061 CDS An14g03630 4987219 complement(join(905979..907566,907648..908012)) I 1 NT_166529.1 Remark: the matching coding sequence was isolated by RT-PCR on all of the mRNA from A. thaliana.; Remark: there are no further informations about the patent available.; Similarity: the ORF encoded protein shows also strong similarities to RNA helicases.; Title: strong similarity to protein fragment SEQ ID NO:48636 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 908012 4987219 An14g03630 Aspergillus niger uncharacterized protein XP_001400988.1 905979 R 5061 CDS An14g03640 4987220 complement(join(909384..909743,909807..910796)) I 1 NT_166529.1 Catalytic activity: Salicylate + NADH + O2 = Catechol + NAD+ + H2O + CO2.; Cofactor: FAD.; Function: salA from Acinetobacter was cloned into pUC18 together with salR and salE, and its gene product showed salicylate-inducible hydroxylase activity against a range of substituted salicylates.; Title: strong similarity to salicylate hydroxylase salA - Acinetobacter sp.; See PMID 10715011; uncharacterized protein 910796 4987220 An14g03640 Aspergillus niger uncharacterized protein XP_001400989.1 909384 R 5061 CDS An14g03650 84592964 join(911682..912264,912304..912418,912526..912532) I 1 NT_166529.1 Similarity: the similarities are mainly based on repetetive structures.; Title: weak similarity to syndecan-1 gene Xsyn-1 -Xenopus laevis; uncharacterized protein 912532 84592964 An14g03650 Aspergillus niger uncharacterized protein XP_059604661.1 911682 D 5061 CDS An14g03660 4987222 complement(join(912836..913662,913719..914117,914179..914505,914561..915175,915235..915703,915787..915837)) I 1 NT_166529.1 Remark: the matching coding sequence was isolated by RT-PCR on all of the mRNA from A. thaliana.; Remark: there are no further informations about the patent available.; Similarity: the ORF encoded protein shows also strong similarities to putative membrane proteins.; Title: strong similarity to protein fragment SEQ ID NO:22357 from patent EP1033405-A2 - Arabidopsis thaliana; plasma membrane; uncharacterized protein 915837 4987222 An14g03660 Aspergillus niger uncharacterized protein XP_059604662.1 912836 R 5061 CDS An14g03670 84592965 join(915853..916041,916103..916165,916237..916340,916424..916718) I 1 NT_166529.1 Title: weak similarity to retinitis pigmentosa GTPase regulator RPGR - Bos taurus; uncharacterized protein 916718 84592965 An14g03670 Aspergillus niger uncharacterized protein XP_059604663.1 915853 D 5061 CDS An14g03680 84592966 complement(join(916940..917332,917454..917459)) I 1 NT_166529.1 hypothetical protein 917459 84592966 An14g03680 Aspergillus niger hypothetical protein XP_059604664.1 916940 R 5061 CDS An14g03685 84592967 918259..918531 I 1 NT_166529.1 hypothetical protein 918531 84592967 An14g03685 Aspergillus niger hypothetical protein XP_059604665.1 918259 D 5061 CDS An14g03690 84592968 join(918825..918959,919002..919193) I 1 NT_166529.1 hypothetical protein 919193 84592968 An14g03690 Aspergillus niger hypothetical protein XP_059604666.1 918825 D 5061 CDS An14g03700 4987227 complement(join(921305..922270,922365..922735,922777..922870)) I 1 NT_166529.1 Title: weak similarity to protein fragment SEQ ID NO:52297 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 922870 4987227 An14g03700 Aspergillus niger uncharacterized protein XP_001400996.3 921305 R 5061 CDS An14g03710 4987228 join(924011..925659,925723..925862,925923..926893,926958..927080) I 1 NT_166529.1 Phenotype: mis5 deletion in S. pombe results in DNA replication defect and hypersensitivity to UV ray and hydroxyurea.; Phenotype: mis5 mutation in S. pombe leads to high loss rates of minichromosomes.; Remark: mis5 is essential for viability.; Similarity: mis5 from S. pombe encodes a novel member of the ubiquitous MCM family required for the onset of replication.; Title: strong similarity to replication licensing factor mis5p - Schizosaccharomyces pombe; See PMID 7865880; uncharacterized protein 927080 4987228 An14g03710 Aspergillus niger uncharacterized protein XP_059604667.1 924011 D 5061 CDS An14g03720 4987229 join(927991..928210,928267..928768,928821..929532,929662..929746,929794..929881,929931..930059,930117..930274,930342..930441,930510..930597,930750..930882,930915..930983,931023..931813,931870..932049,932099..932413) I 1 NT_166529.1 Function: RAD5 of S. cerevisiae has single-stranded DNA-dependent ATPase activity, and is involved in error-free DNA repair.; Remark: RAD5 of S. cerevisiae is also called REV2,SNM2 or YLR032W.; Similarity: the predicted ORF shows equally strong similarity to the S. cerevisiae RAD5 protein, a putative helicase of S. pombe, the DNA repair protein RAD16 of S. cerevisiae and other related proteins from diverse eucaryotic species.; Title: strong similarity to DNA repair protein Rad5 - Saccharomyces cerevisiae; See PMID 8290359; See PMID 1324406; See PMID 9016623; See PMID 9637242; See PMID 10430580; uncharacterized protein 932413 4987229 An14g03720 Aspergillus niger uncharacterized protein XP_059604668.1 927991 D 5061 CDS An14g03730 4987230 complement(join(932887..933702,933807..934391,934673..934874,935006..935157,935188..935230,935357..937481,937604..937748,937813..937878)) I 1 NT_166529.1 Induction: transcription of M14 from M. musculus is dramatically induced (about 70-fold) by isoproterenol treatment.; Similarity: the ORF also shows strong similarity to the EST SEQ ID NO:4359 of patent WO200056762-A2 from Aspergillus niger.; Similarity: the similarities are based on repetetive structures.; Title: similarity to hypothetical proline-rich protein M14 - Mus musculus; See PMID 2839509; uncharacterized protein 937878 4987230 An14g03730 Aspergillus niger uncharacterized protein XP_059604669.1 932887 R 5061 CDS An14g03740 4987231 complement(join(939007..939324,939379..939705,939775..942350,942405..942549)) I 1 NT_166529.1 Title: strong similarity to hypothetical protein SPCC14G10.02 - Schizosaccharomyces pombe; uncharacterized protein 942549 4987231 An14g03740 Aspergillus niger uncharacterized protein XP_001401000.1 939007 R 5061 CDS An14g03760 4987233 join(943919..944356,944511..944561) I 1 NT_166529.1 Title: weak similarity to endoglucanase from patent WO9110732-A - Bacillus sp.; uncharacterized protein 944561 4987233 An14g03760 Aspergillus niger uncharacterized protein XP_059604670.1 943919 D 5061 CDS An14g03770 4987234 complement(944802..948497) I 1 NT_166529.1 Remark: expression of human HRH1 in a S. cerevisiae prp22 (RNA helicase) mutant can partially rescue its temperature-sensitive phenotype.; Title: strong similarity to RNA helicase 1 HRH1 -Homo sapiens; nucleus; See PMID 7935475; uncharacterized protein 948497 4987234 An14g03770 Aspergillus niger uncharacterized protein XP_001401002.1 944802 R 5061 CDS An14g03780 4987235 complement(join(948952..949936,949986..950929)) I 1 NT_166529.1 Function: the DExH box protein Suv3p from S. cerevisiaeis a component of a yeast mitochondrial 3'-to-5' exoribonuclease that suppresses group I intron toxicity.; Remark: synonyms for Suv3 from S. cerevisiae are Lpb2 and YPL029w.; Title: strong similarity to mitochondrial RNA helicase Suv3 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8565066; See PMID 1379722; uncharacterized protein 950929 4987235 An14g03780 Aspergillus niger uncharacterized protein XP_001401003.3 948952 R 5061 CDS An14g03790 4987236 join(952047..952080,952142..952179,952271..952358,952419..952565,952616..952818,952865..953331,953383..954493) I 1 NT_166529.1 Function: Microinjection of Sec1 from L. pealei into the presynaptic terminal of the giant synapse inhibited evoked neurotransmitter release, but this effect was prevented by coinjecting the cytoplasmic domain of L. pealei syntaxin, one of the binding partners of Sec1.; Remark: Sec1-related proteins are essential for membrane fusion at distinct stages of the constitutive and regulated secretory pathways in eukaryotic cells.; Title: strong similarity to sec1-like protein -Loligo pealei; See PMID 9526009; uncharacterized protein 954493 4987236 An14g03790 Aspergillus niger uncharacterized protein XP_001401004.1 952047 D 5061 CDS An14g03800 4987237 complement(954694..955512) I 1 NT_166529.1 Title: weak similarity to sexual differentiation protein esc1p - Schizosaccharomyces pombe; uncharacterized protein 955512 4987237 An14g03800 Aspergillus niger uncharacterized protein XP_059604671.1 954694 R 5061 CDS An14g03810 4987238 join(955762..955938,956010..956468,956562..957155) I 1 NT_166529.1 Similarity: the protein shows weaker similarity to a human patented sequence (patent number EP1067182-A2) and a number of hypothetical proteins, some of which annotated as oxidoreductases with various specificity; the predicted protein indeed contains structural features common to short-chain alcohol dehydrogenases.; Title: strong similarity to hypothetical protein SPAC19A8.06 - Schizosaccharomyces pombe; uncharacterized protein 957155 4987238 An14g03810 Aspergillus niger uncharacterized protein XP_059604672.1 955762 D 5061 CDS An14g03820 4987239 complement(join(957440..957834,957893..958349,958450..958684,958753..958781)) I 1 NT_166529.1 Function: GAL10 of S. cerevisiae converts UDP-glucose to UDP-galactose, being involved in the galactose metabolism pathway.; Similarity: the predicted protein shows a very strong similarity to the N-terminal half of GAL10 of S. cerevisiae; the C-terminal half of the yeast gene is missing from the predicted protein.; Title: strong similarity to UDP-glucose 4-epimerase Gal10 - Saccharomyces cerevisiae; cytoplasm; See PMID 7601342; uncharacterized protein 958781 4987239 An14g03820 Aspergillus niger uncharacterized protein XP_001401007.1 957440 R 5061 CDS An14g03830 84592969 join(959461..959472,959636..959724,959811..959944,960119..960170,960460..960535) I 1 NT_166529.1 hypothetical protein 960535 84592969 An14g03830 Aspergillus niger hypothetical protein XP_059604673.1 959461 D 5061 CDS An14g03850 4987242 complement(join(961041..961093,961230..961312,961362..961528,961587..961697,961752..962602,962654..962864)) I 1 NT_166529.1 Function: TRI4 gene of Fusarium sporotrichioides encodes a cytochrome P450 monooxygenase involved in trichothecene biosynthesis.; Phenotype: disruption of TRI4 results in the loss of production of both trichothecenes and apotrichodiol and the accumulation of the unoxygenated pathway intermediate trichodiene.; Remark: trichothecenes are sesquiterpenoid toxins that act by inhibiting protein biosynthesis.; Similarity: the TRI4 gene has been placed in a new cytochrome P450 gene family designated CY P58.; Title: strong similarity to cytochrome P450 monooxygenase TRI4 - Fusarium sporotrichioides; See PMID 7651333; uncharacterized protein 962864 4987242 An14g03850 Aspergillus niger uncharacterized protein XP_059604674.1 961041 R 5061 CDS An14g03860 84592970 join(963014..963063,963157..963271,963339..963439,963485..963632,963724..963765) I 1 NT_166529.1 hypothetical protein 963765 84592970 An14g03860 Aspergillus niger hypothetical protein XP_059604675.1 963014 D 5061 CDS An14g03870 4987244 complement(join(963938..964584,964663..965551)) I 1 NT_166529.1 Function: AvnA is involved in the conversion of averantin to averufin in aflatoxin biosynthesis in Aspergillus parasiticus.; Remark: Aflatoxins are toxic and carcinogenic secondary metabolites produced by the fungi Aspergillus flavus and A. parasiticus.; Remark: as other polyketides, aflatoxins are synthesized by condensation of acetate units.; Similarity: The avnA gene encodes a cytochrome P-450-type monooxygenase that has been assigned to a new P-450 gene family named CYP60A1.; Title: strong similarity to cytochrome P450 monooxygenase avnA - Aspergillus parasiticus; See PMID 7793957; See PMID 9097431; uncharacterized protein 965551 4987244 An14g03870 Aspergillus niger uncharacterized protein XP_001401011.1 963938 R 5061 CDS An14g03880 84592971 complement(join(966060..966154,966236..966281,966320..966385,966494..966629,966677..966972)) I 1 NT_166529.1 hypothetical protein 966972 84592971 An14g03880 Aspergillus niger hypothetical protein XP_059604676.1 966060 R 5061 CDS An14g03890 4987246 complement(join(967405..967498,967584..969285,969340..969824,969915..970063)) I 1 NT_166529.1 Complex: PAT1 of S. cerevisiae interacts with the Lsm decapping complex.; Function: PAT1 of S. cerevisiae is involved in mRNA decapping and degradation, as well as for faithful chromosome transmission during mitosis and meiosis.; Similarity: the alignment of the predicted protein to PAT1 of S. cerevisiae has several gaps; a better alignment is obtained to the putative S. pombe homologue of S. cerevisiae PAT1.; Title: similarity to topoisomerase II-associated protein Pat1 - Saccharomyces cerevisiae; cytoplasm; See PMID 8816497; See PMID 8972867; See PMID 9077451; See PMID 10394921; See PMID 10913177; uncharacterized protein 970063 4987246 An14g03890 Aspergillus niger uncharacterized protein XP_059604677.1 967405 R 5061 CDS An14g03900 84592972 complement(join(970500..970622,970711..970786,970893..971105,971159..971172)) I 1 NT_166529.1 hypothetical protein 971172 84592972 An14g03900 Aspergillus niger hypothetical protein XP_059604678.1 970500 R 5061 CDS An14g03910 4987248 join(971296..971337,971391..972173,972225..972513,972564..972628) I 1 NT_166529.1 Function: kre2 of C. albicans is involved in the synthesis of mannoproteins, the third major class of macromolecule found in the cell wall.; Function: kre2 of C. albicans transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-1,2-D-mannosyl-D-mannose linkage.; Golgi; Phenotype: both heterozygous and homozygous kre2 null mutants of C. albicans showed strong attenuation of virulence in guinea pig and mouse models of systemic candidosis, which, in guinea pigs, could be attributed to a decreased ability to reach and/or adhere internal organs.; Phenotype: the absence of kre2 in C. albicans reduced the ability of C. albicans cells to adhere to each other, to human buccal epithelial cells, and to rat vaginal epithelial cells.; Remark: kre2 of C. albicans is also called mnt1.; Title: strong similarity to alpha-1,2-mannosyltransferase kre2 - Candida albicans; uncharacterized protein 972628 4987248 An14g03910 Aspergillus niger uncharacterized protein XP_001401015.1 971296 D 5061 CDS An14g03920 4987249 complement(join(973214..973279,973344..973444,973570..974023)) I 1 NT_166529.1 Similarity: the predicted ORF is 60 amino acids longer at its N-terminus than other S12 proteins.; Title: strong similarity to ribosomal protein of the small subunit Rps12 - Saccharomyces cerevisiae; See PMID 11279123; mitochondrial 37S ribosomal protein uS12m 974023 4987249 An14g03920 Aspergillus niger mitochondrial 37S ribosomal protein uS12m XP_001401016.1 973214 R 5061 CDS An14g03930 4987250 join(974428..974430,974517..974952,975045..975112) I 1 NT_166529.1 Function: the S. cerevisiae Ump1p is a chaperone and component of proteasome precursor complexes containing unprocessed beta subunits but is not detected in the mature 20S proteasome.; Induction: the propeptide of the Pre2p/Doa3p beta subunit is required for ump1p's function in proteasome maturation.; Induction: transcript levels of mammalian ump1 are increased after IFN-gamma treatment.; Phenotype: S. cerevisiae cells lacking ump1 exhibit a lack of coordination between the processing of beta subunits and proteasome assembly, resulting in functionally impaired proteasomes.; Remark: UMP1 of S. cerevisiae is also called YBR173C or YBR12.; Title: strong similarity to proteasome 20S maturation factor Ump1 - Saccharomyces cerevisiae; See PMID 9491890; See PMID 10757750; See PMID 10973495; uncharacterized protein 975112 4987250 An14g03930 Aspergillus niger uncharacterized protein XP_001401017.1 974428 D 5061 CDS An14g03940 84592973 join(975485..975592,975673..975800,975875..976025) I 1 NT_166529.1 hypothetical protein 976025 84592973 An14g03940 Aspergillus niger hypothetical protein XP_059604679.1 975485 D 5061 CDS An14g03950 4987252 complement(join(976156..976310,976367..976450,976515..977037)) I 1 NT_166529.1 Title: strong similarity to hypothetical protein EAA60774.1 - Aspergillus nidulans; uncharacterized protein 977037 4987252 An14g03950 Aspergillus niger uncharacterized protein XP_001401019.1 976156 R 5061 CDS An14g03960 84592974 join(977145..977208,977252..977312,977394..977441,977495..977570,977705..977830,977970..978077) I 1 NT_166529.1 hypothetical protein 978077 84592974 An14g03960 Aspergillus niger hypothetical protein XP_059604680.1 977145 D 5061 CDS An14g03970 84592975 join(980214..980352,980446..980541,980672..980763,980830..980934) I 1 NT_166529.1 hypothetical protein 980934 84592975 An14g03970 Aspergillus niger hypothetical protein XP_059604681.1 980214 D 5061 CDS An14g03980 84592976 join(982415..982652,982719..983635,983710..983877) I 1 NT_166529.1 Title: strong similarity to hypothetical 57.9 kd protein - Schizosaccharomyces pombe; uncharacterized protein 983877 84592976 An14g03980 Aspergillus niger uncharacterized protein XP_059604682.1 982415 D 5061 CDS An14g03990 4987256 join(984804..984900,984964..985071,985132..985672,985727..986579) I 1 NT_166529.1 Remark: the systematic name of hxt5 from S. cerevisiae is YHR096C.; Similarity: the ORF shows similarity to several sugar transporter from different species.; Title: strong similarity to hexose transporter Hxt5 - Saccharomyces cerevisiae; plasma membrane; See PMID 7651133; uncharacterized protein 986579 4987256 An14g03990 Aspergillus niger uncharacterized protein XP_001401023.1 984804 D 5061 CDS An14g04000 4987257 join(987778..988389,988440..990134,990198..990269) I 1 NT_166529.1 Function: the regulatory gene amdR of A. oryzae positively regulates the expression of genes involved in the catabolism of certain amides, omega amino acids and lactams.; Induction: amdR of A. oryzae can be induced by omega amino acids.; Phenotype: inactivation of the A. oryzae gene results in the inability to grow on gamma-amino-butyric acid (GABA) as a carbon and/or nitrogen source indicating that GABA utilization is amdR-dependent in A. oryzae.; Similarity: the similarity of the predicted ORF to amdR from A. oryzae is locally high the N-terminal part of the ORF, ending around amino acid 457.; Title: similarity to transcription regulator amdR -Aspergillus oryzae; nucleus; See PMID 2188110; See PMID 1452021; uncharacterized protein 990269 4987257 An14g04000 Aspergillus niger uncharacterized protein XP_001401024.1 987778 D 5061 CDS An14g04010 4987258 complement(join(990504..991608,991660..991783,991846..992008)) I 1 NT_166529.1 Catalytic activity: Erg8 of S. cerevisiae converts ATP + (R)-5-phosphomevalonate = ADP + (R)-5-diphosphomevalonate.; Pathway: second step in isopentenyl diphosphate formation.; Phenotype: disruption of the chromosomal erg8 coding region in S. cerevisiae by integration of URA3 or HIS3 marker fragments was lethal in haploid cells, indicating that this gene is essential.; Remark: Erg8 of S. cerevisiae is also called YMR220W or YM9959. 02.; Similarity: the ORF overlaps with A. niger EST EMBLEST:BE760517.; Title: strong similarity to phosphomevalonate kinase Erg8 - Saccharomyces cerevisiae; cytoplasm; uncharacterized protein 992008 4987258 An14g04010 Aspergillus niger uncharacterized protein XP_059604683.1 990504 R 5061 CDS An14g04020 84592977 complement(992190..992588) I 1 NT_166529.1 hypothetical protein 992588 84592977 An14g04020 Aspergillus niger hypothetical protein XP_059604684.1 992190 R 5061 CDS An14g04030 84592978 join(992948..993033,993123..993143,993204..993398,993488..993668) I 1 NT_166529.1 hypothetical protein 993668 84592978 An14g04030 Aspergillus niger hypothetical protein XP_059604685.1 992948 D 5061 CDS An14g04040 4987261 994514..998341 I 1 NT_166529.1 Remark: a splice site was detected upstream of the START codon.; Similarity: the similarity of the predicted ORF to the hypothetical protein from S. pombe is locally high at its C-terminal end starting around amino acid 850.; Title: strong similarity to hypothetical protein SPAC1093.01 with conserved domain PF01535 duf17p -Schizosaccharomyces pombe; uncharacterized protein 998341 4987261 An14g04040 Aspergillus niger uncharacterized protein XP_001401028.1 994514 D 5061 CDS An14g04050 4987262 join(999010..999073,999127..999549,999649..999824,999906..1000099,1000414..1000624) I 1 NT_166529.1 Catalytic activity: pdx3 of S. cerevisiae converts pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + H2O2.; Induction: due to the presence of gcn4p binding sequences in the pdx3 promoter region it is assumed that transcription of this gene is under the general control of nitrogen.; Pathway: de novo synthesis of pyridoxine (vitamine B6) and pyridoxal phosphate.; Remark: alternate names for pdx3 of S. crevisiae are YBR032 or YBR035c.; Similarity: the ORF overlaps with A. niger EST PATENTDNA:AAF11550 EST SEQ ID NO:4073.; Similarity: the similarity of the ORF to pdx3 of S. cerevisiae is restricted to the inner part of the ORF,spanning the region between amino acid 105 and 285.; Title: strong similarity to pyridoxamine-phosphate oxidase Pdx3 - Saccharomyces cerevisiae; uncharacterized protein 1000624 4987262 An14g04050 Aspergillus niger uncharacterized protein XP_059604686.1 999010 D 5061 CDS An14g04060 4987263 complement(join(<1001190..1002122,1002172..1002899,1002950..1003027,1003076..1003435,1003487..1003554,1003617..1004088)) I 1 NT_166529.1 Function: clcn3 of M. musculus is an voltage-gated channel, which is active in chloride transport.; Remark: an alternative name for clcn3 is clc3.; Title: strong similarity to chloride channel 3 clcn3 - Mus musculus [putative frameshift]; putative frameshift; See PMID 7665160; uncharacterized protein 1004088 4987263 An14g04060 Aspergillus niger uncharacterized protein XP_059604687.1 1001190 R 5061 CDS An14g04070 4987264 join(1004120..1004158,1004392..1004518,1004599..1004730,1004811..1004866,1004945..1005035,1005094..1005404) I 1 NT_166529.1 Function: cbf-C of R. norvegicus is forming together with cbf-A and cbf-B the cbf-DNA complex, which binds to CCAAT motifs present in many eukaryotic promoters.; Similarity: a significant similarity of the predicted ORF to CCAAT binding transcription factor C subunits of several species starts with amino acid 100 of the ORF.; Title: similarity to CCAAT binding transcription factor subunit C cbf-C - Rattus norvegicus; nucleus; See PMID 7878029; uncharacterized protein 1005404 4987264 An14g04070 Aspergillus niger uncharacterized protein XP_059604688.1 1004120 D 5061 CDS An14g04080 4987265 join(1006018..1006312,1006471..1006559,1006645..1006795,1006859..1007040) I 1 NT_166529.1 Function: rip1 from S. pombe is part of the respiratory chain complex in the inner mitochondrial membrane (complex III or cytochrome b-c1).; Remark: rip1 from S. pombe is also called Rieske iron-sulfur protein or rsp.; Remark: the systematic name of rip1 from S. pombe is SPBC16H5. 0.; Similarity: the ORF overlaps with A. niger ESTs EMBLEST:AN754, PATENTDNA:AAF11289 EST SEQ ID NO:3812 and PATENTDNA:AAF14587 EST SEQ ID NO:7110.; Title: strong similarity to iron-sulfur subunit of ubiquinol--cytochrome c reductase rip1p -Schizosaccharomyces pombe; localisation:mitochondrion; uncharacterized protein 1007040 4987265 An14g04080 Aspergillus niger uncharacterized protein XP_001401032.1 1006018 D 5061 CDS An14g04090 4987266 complement(join(1007739..1008655,1008727..1009309)) I 1 NT_166529.1 Similarity: the ORF shows similarity to the homologues protein of she9 from C. albicans, SPAC823. 13c from S. pombe and YDR393w from S. cerevisiae.; Similarity: the similarity of the ORF to these hypothetical proteins is restricted to its innner part,spanning the region from amino acid 150 to 350.; Title: strong similarity to hypothetical protein she9 - Candida albicans; uncharacterized protein 1009309 4987266 An14g04090 Aspergillus niger uncharacterized protein XP_001401033.1 1007739 R 5061 CDS An14g04100 4987267 complement(join(1009891..1010300,1010364..1010421)) I 1 NT_166529.1 Similarity: some of the hypothetical protein are putative membrane proteins and/or stress responsive.; Similarity: the similarity to several hypothetical proteins is restricted to the first third of the ORF,ending around amino acid 60.; Title: similarity to hypothetical protein ZK632.10 -Caenorhabditis elegans; uncharacterized protein 1010421 4987267 An14g04100 Aspergillus niger uncharacterized protein XP_001401034.1 1009891 R 5061 CDS An14g04110 84592979 complement(join(1011493..1011617,1011716..1011801,1011902..1011987)) I 1 NT_166529.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF; uncharacterized protein 1011987 84592979 An14g04110 Aspergillus niger uncharacterized protein XP_059604689.1 1011493 R 5061 CDS An14g04120 84592980 complement(join(1012239..1012413,1012491..1012566,1012654..1012779,1012857..1012985,1013043..1013073)) I 1 NT_166529.1 hypothetical protein 1013073 84592980 An14g04120 Aspergillus niger hypothetical protein XP_059604690.1 1012239 R 5061 CDS An14g04130 84592981 join(1013145..1013189,1013330..1013683) I 1 NT_166529.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF; uncharacterized protein 1013683 84592981 An14g04130 Aspergillus niger uncharacterized protein XP_059604691.1 1013145 D 5061 CDS An14g04140 4987271 join(1014111..1014205,1014257..1014340,1014399..1014561,1014620..1015837) I 1 NT_166529.1 Function: c-cam105 is conferring the ability to pump out [3H]taurocholate when expressed in cos cells.; Function: c-cam105 of R. norvegicus is a calcium-independent cell adhesion molecule, which may play a role in the formation and maintainance of the structure of the apical surface of rat hepatocytes.; Induction: phosphorylation of the cytoplasmic tail of c-cam105 is essential for bile acid efflux activity but not for ATPase activity.; Remark: c-cam105 of R. norvegicus is also called C-CAM, ATP-dependent taurocolate-carrier protein or gp110.; Similarity: the ORF shows similarity to several serine-rich proteins.; Similarity: the predicted ORF is 184 amino acids shorter at its N-terminus than c-cam105 of R. norvegicus.; Title: similarity to ecto-ATPase c-cam105 - Rattus norvegicus; plasma membrane; See PMID 8380406; See PMID 8420979; uncharacterized protein 1015837 4987271 An14g04140 Aspergillus niger uncharacterized protein XP_001401038.1 1014111 D 5061 CDS An14g04150 84592982 join(1016240..1016332,1016499..1016645) I 1 NT_166529.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF; uncharacterized protein 1016645 84592982 An14g04150 Aspergillus niger uncharacterized protein XP_059604692.1 1016240 D 5061 CDS An14g04160 4987273 join(1017552..1017557,1017621..1017631,1017740..1018000,1018068..1018116,1018179..1018319) I 1 NT_166529.1 Function: cofilin cof1 of S. cerevisiae is an essential component of the yeast cortical cytoskeleton, a low-molecular weight actin-binding and depolymerizing protein with several activities in vitro.; Induction: cofilin activity is regulated by phosphorylation.; Remark: a splice site was detected upstream of the START codon.; Remark: the systematic name for cof1 of S. cerevisiae is YLL050C.; Similarity: the ORF overlaps with A. niger ESTs EMBLEST:BE759006 and EMBLEST:BE759053.; Title: strong similarity to cofilin Cof1 -Saccharomyces cerevisiae; cytoskeleton; See PMID 4055781; See PMID 9078368; See PMID 10231390; uncharacterized protein 1018319 4987273 An14g04160 Aspergillus niger uncharacterized protein XP_001401040.1 1017552 D 5061 CDS An14g04170 4987274 join(1019266..1019575,1019671..>1019675) I 1 NT_166529.1 Function: cytochrome c oxidase subunit V cox5 of A. niger is part of the respiratory chain of the mitochondrial oxidative phosphorylation process.; Gene-ID: cox5; Remark: the ORF is C-terminally truncated due to the contig border.; Similarity: the ORF overlaps with EMBL:ANI132229 (A. niger cox5 gene, exons 1-3) and PATENTDNA:AAF11256 (A. niger EST SEQ ID NO:3779).; localisation:mitochondrion; See PMID 10503533; See PMID 11245784; cytochrome c oxidase subunit V cox5-Aspergillus niger [truncated ORF] 1019675 cox5 4987274 cox5 Aspergillus niger cytochrome c oxidase subunit V cox5-Aspergillus niger [truncated ORF] XP_001401041.3 1019266 D 5061 CDS An14g04180 4987275 join(<1019779..1020244,1020308..1020390) I 1 NT_166529.1 Catalytic activity: H+-transporting ATP synthases produce a proton gradient and convert ADP + phosphate <=> ATP + H(2)O.; Remark: the ORF is N-terminally truncated (330 to 340 amino acids) due to contig border.; Similarity: the ORF overlaps with A. niger EST EMBLEST:BE758985.; Title: strong similarity to H+-transporting ATP synthase beta chain - Neurospora crassa [truncated ORF]; localisation:mitochondrion; uncharacterized protein 1020390 4987275 An14g04180 Aspergillus niger uncharacterized protein XP_001401042.1 1019779 D 5061 CDS An14g04190 4987276 complement(join(1021530..1021556,1021622..1022252,1022305..1022640,1022693..1023384,1023447..1023559,1023615..1023714,1023817..1023941,1024011..1024065)) I 1 NT_166529.1 Function: glc3 of S. cerevisiae is involved in glycogen/starch biosynthesis by catalyzing the transglycosylation of a terminal segment of a 1,4-alpha-D-glucan chain to an unbranched chain, thereby converting amylose to amylopectin or creating branches in glycogen.; Induction: glc3 of S. cerevisiae is expressed during the transition between the late exponential and stationary growth phases, coincident with maximal glycogen accumulation.; Phenotype: the null mutant of glc3 in S. cerevisiais is viable, but glycogen deficient.; Remark: glc3 of S. cerevisiae is also called gha1 or YEL011W.; Similarity: the ORF overlaps with A. niger EST EMBLEST:BE760568.; Title: strong similarity to 1,4-alpha-glucan branching enzyme Glc3 - Saccharomyces cerevisiae; cytoplasm; See PMID 8150278; See PMID 1634552; See PMID 1729600; uncharacterized protein 1024065 4987276 An14g04190 Aspergillus niger uncharacterized protein XP_001401043.1 1021530 R 5061 CDS An14g04200 4987277 complement(join(1024872..1025671,1025743..1025944,1026000..1026038,1026092..1026727)) I 1 NT_166529.1 Function: rhamnogalacturonase rhgB of A. niger is involved in the oligoglycosyl fragment generation from the backbone of rhamnogalacturonan, a component of cell walls by hydrolysing the 1,4-alpha-D-galactosiduronic linkages.; Gene-ID: rhgB; Induction: the rhgB gene of A. niger was derepressed after 18 h of growth on either apple pectin or sucrose.; Similarity: the ORF is identical to the database entry for the A. niger rhgB protein, but differs at amino acid 226 (G to S), which lies in a splice site.; Similarity: the ORF overlaps nearly completely with A. niger EST EMBL:ANRHGBGEN (rhgB gene).; See PMID 9299700; rhamnogalacturonase rhgB-Aspergillus niger 1026727 rhgB 4987277 rhgB Aspergillus niger rhamnogalacturonase rhgB-Aspergillus niger XP_001401044.1 1024872 R 5061 CDS An14g04210 4987278 complement(1028194..1029093) I 1 NT_166529.1 Remark: the similarity of the predicted ORF to the Drosophila gene reaches over its whole lenght.; Title: similarity to hypothetical protein encoded by An07g05660 - Aspergillus niger; uncharacterized protein 1029093 4987278 An14g04210 Aspergillus niger uncharacterized protein XP_001401045.1 1028194 R 5061 CDS An14g04220 84592983 complement(join(1029364..1029469,1029615..1029754)) I 1 NT_166529.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF; uncharacterized protein 1029754 84592983 An14g04220 Aspergillus niger uncharacterized protein XP_059605556.1 1029364 R 5061 CDS An14g04230 84592984 join(1029928..1029980,1030115..1030179,1030432..1030491,1030721..1031044,1031164..1031375) I 1 NT_166529.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF; uncharacterized protein 1031375 84592984 An14g04230 Aspergillus niger uncharacterized protein XP_059605557.1 1029928 D 5061 CDS An14g04240 4987281 complement(join(1031757..1032213,1032301..1033067,1033122..1033555,1033614..1034013)) I 1 NT_166529.1 Similarity: the ORF shows strong similarity to several conserved hypothetical proteins from bacteria,which are immunoreactive antigens.; Title: strong similarity to hypothetical conserved protein CC0533 - Caulobacter crescentus; uncharacterized protein 1034013 4987281 An14g04240 Aspergillus niger uncharacterized protein XP_001401048.3 1031757 R 5061 CDS An14g04250 84592985 join(1034209..1034641,1034827..1034918,1035186..1035358,1035461..1035503,1035997..1036110) I 1 NT_166529.1 hypothetical protein 1036110 84592985 An14g04250 Aspergillus niger hypothetical protein XP_059605558.1 1034209 D 5061 CDS An14g04260 4987283 complement(1036844..1037590) I 1 NT_166529.1 Title: strong similarity to hypothetical protein PA4181 - Pseudomonas aeruginosa; uncharacterized protein 1037590 4987283 An14g04260 Aspergillus niger uncharacterized protein XP_001401050.1 1036844 R 5061 CDS An14g04270 84592986 join(1039457..1039505,1039896..1039993,1040077..1040286) I 1 NT_166529.1 hypothetical protein 1040286 84592986 An14g04270 Aspergillus niger hypothetical protein XP_059605559.1 1039457 D 5061 CDS An14g04280 4987285 join(1040724..1040793,1040853..1041991,1042048..1042395) I 1 NT_166529.1 Function: qutD of A. nidulans is required for the transport of quinate into the mycelium.; Similarity: qutD of A. nidulans belongs to the sugar transporter family.; Title: strong similarity to quinate transport protein qutD - Aspergillus nidulans; plasma membrane; See PMID 2835177; See PMID 2976880; uncharacterized protein 1042395 4987285 An14g04280 Aspergillus niger uncharacterized protein XP_001401052.1 1040724 D 5061 CDS An14g04290 4987286 join(1043955..1043957,1044074..1044195,1044247..1044314,1044366..1044631,1044690..1045676) I 1 NT_166529.1 Title: strong similarity to hypothetical amidase -Schizosaccharomyces pombe; uncharacterized protein 1045676 4987286 An14g04290 Aspergillus niger uncharacterized protein XP_059605560.1 1043955 D 5061 CDS An14g04300 4987287 join(1046004..1046232,1046299..1046512,1046585..1047590) I 1 NT_166529.1 Title: strong similarity to molybdenum cofactor biosynthetic protein - Aspergillus nidulans; See PMID 9614089; See PMID 10383438; uncharacterized protein 1047590 4987287 An14g04300 Aspergillus niger uncharacterized protein XP_001401054.1 1046004 D 5061 CDS An14g04310 84592987 complement(join(1048128..1048263,1048306..1048583,1048669..1048797)) I 1 NT_166529.1 hypothetical protein 1048797 84592987 An14g04310 Aspergillus niger hypothetical protein XP_059605561.1 1048128 R 5061 CDS An14g04320 4987289 join(1048853..1049007,1049058..1049090,1049146..1050484,1050534..1051666,1051737..1052097) I 1 NT_166529.1 Title: strong similarity to hypothetical protein SPAC57A7.05 - Schizosaccharomyces pombe; uncharacterized protein 1052097 4987289 An14g04320 Aspergillus niger uncharacterized protein XP_001401056.3 1048853 D 5061 CDS An14g04330 4987290 join(1052699..1053098,1053160..1053500,1053677..1053907) I 1 NT_166529.1 Title: similarity to hypothetical short chain alcohol dehydrogenase cta - Cucumis sativus; uncharacterized protein 1053907 4987290 An14g04330 Aspergillus niger uncharacterized protein XP_059605562.1 1052699 D 5061 CDS An14g04340 4987291 join(1054219..1054461,1054544..1055263,1055314..1055937) I 1 NT_166529.1 Function: urdJ from Streptomyces fradiae is involved in the urdamycin biosynthetis.; Title: similarity to transporter involved in urdamycin biosynthesis - Streptomyces fradiae; See PMID 10658661; uncharacterized protein 1055937 4987291 An14g04340 Aspergillus niger uncharacterized protein XP_059605563.1 1054219 D 5061 CDS An14g04350 84592988 complement(1056372..1056725) I 1 NT_166529.1 hypothetical protein 1056725 84592988 An14g04350 Aspergillus niger hypothetical protein XP_059605564.1 1056372 R 5061 CDS An14g04360 84592989 join(1057400..1057435,1057502..1057627) I 1 NT_166529.1 Title: questionable ORF; uncharacterized protein 1057627 84592989 An14g04360 Aspergillus niger uncharacterized protein XP_059605565.1 1057400 D 5061 CDS An14g04370 4987294 complement(join(1057913..1058248,1058303..1058536,1058600..1058696,1058745..1058870,1058923..1059269)) I 1 NT_166529.1 Gene-ID: pelA; See PMID 1934134; See PMID 2225145; pectin lyase pelA-Aspergillus niger 1059269 pelA 4987294 pelA Aspergillus niger pectin lyase pelA-Aspergillus niger XP_001401061.1 1057913 R 5061 CDS An14g04380 84592990 join(1059646..1059738,1059809..1059863,1060019..1060072,1060316..1060419,1060499..1060545,1060584..1060754,1060969..1061115,1061195..1061283,1061367..1061431) I 1 NT_166529.1 hypothetical protein 1061431 84592990 An14g04380 Aspergillus niger hypothetical protein XP_059605566.1 1059646 D 5061 CDS An14g04395 84592991 1062370..>1062549 I 1 NT_166529.1 Catalytic activity: EC 1. 3. 5. 1 catalyzes the transfer of two electrons from succinate to ubiquinon via FAD yielding fumarate and ubiquinol.; Complex: Sdh2p of S. cerevisiae forms part of the heterotetrameric Succinate dehydrogenase complex (complex II) consisting of a flavoprotein (Sdh1p), an iron-sulfur protein (Sdh2p), a cytochrome b and a membrane-anchoring protein.; Function: Sdh2p of S. cerevisiae contains three different iron-sulfur clusters.; Localization: the SDH complex of S. cerevisiae is integrated in the mitochondrial inner membrane.; Pathway: EC 1. 3. 5. 1 is a key enzyme in the tricarboxylic-acid cycle.; Remark: the ORF continues on the adjacent contig.; Remark: the ORF is N-terminally truncated due to end of contig.; Title: strong similarity to succinate dehydrogenase iron-sulfur protein subunit Sdh2 - Saccharomyces cerevisiae [truncated ORF]; localisation:mitochondrion; See PMID 9822678; See PMID 2191948; uncharacterized protein 1062549 84592991 An14g04395 Aspergillus niger uncharacterized protein XP_059605567.1 1062370 D 5061 CDS An14g04400 4987297 join(<1062655..1062675,1062731..1063054) I 1 NT_166529.1 Catalytic activity: EC 1. 3. 5. 1 catalyzes the transfer of two electrons from succinate to ubiquinon via FAD yielding fumarate and ubiquinol.; Complex: Sdh2p of S. cerevisiae forms part of the heterotetrameric Succinate dehydrogenase complex (complex II) consisting of a flavoprotein (Sdh1p), an iron-sulfur protein (Sdh2p), a cytochrome b and a membrane-anchoring protein.; Function: Sdh2p of S. cerevisiae contains three different iron-sulfur clusters.; Localization: the SDH complex of S. cerevisiae is integrated in the mitochondrial inner membrane.; Pathway: EC 1. 3. 5. 1 is a key enzyme in the tricarboxylic-acid cycle.; Remark: the ORF is N-terminally truncated due to end of contig.; Title: strong similarity to succinate dehydrogenase iron-sulfur protein subunit Sdh2 - Saccharomyces cerevisiae [truncated ORF]; localisation:mitochondrion; See PMID 2191948; See PMID 9822678; uncharacterized protein 1063054 4987297 An14g04400 Aspergillus niger uncharacterized protein XP_001401064.3 1062655 D 5061 CDS An14g04410 4987298 complement(join(1063461..1063526,1063564..1063615,1063837..1064696)) I 1 NT_166529.1 Catalytic activity: EC 4. 1. 2. 13 catalyses the reversible cleavage of fructose-1,6-bisphosphate to dihydroxyacetone phosphate and glyceraldehyde-3-phosphate.; Complex: fructose-1,6-bisphosphate aldolase of T. aquaticus forms a homotetramer.; Pathway: EC 4. 1. 2. 13 is an enzyme of the glycolysis and gluconeogenesis pathways.; Title: strong similarity to fructose-1,6-bisphosphate aldolase - Thermus aquaticus; cytoplasm; See PMID 8898912; See PMID 11173490; See PMID 11237691; uncharacterized protein 1064696 4987298 An14g04410 Aspergillus niger uncharacterized protein XP_001401065.3 1063461 R 5061 CDS An14g04420 4987299 complement(join(1064938..1065498,1065547..1066040,1066086..1066341)) I 1 NT_166529.1 Catalytic activity: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH.; Remark: the amino acid sequence of 3-hydroxyisobutyrate dehydrogenase shows similarity to several other pyridine nucleotide-dependent dehydrogenases. The resemblance to malate and lactate dehydrogenases suggests that the nucleotide-binding domain is located in the N-terminal region of the protein.; Title: similarity to 3-hydroxyisobutyrate dehydrogenase - Rattus norvegicus; See PMID 1339433; See PMID 2647728; uncharacterized protein 1066341 4987299 An14g04420 Aspergillus niger uncharacterized protein XP_001401066.1 1064938 R 5061 CDS An14g04430 84592992 join(1066419..1066552,1066649..1066736,1066841..1066897) I 1 NT_166529.1 hypothetical protein 1066897 84592992 An14g04430 Aspergillus niger hypothetical protein XP_059602302.1 1066419 D 5061 CDS An14g04440 84592993 complement(join(1067258..1067341,1067416..1067469)) I 1 NT_166529.1 Title: questionable ORF; uncharacterized protein 1067469 84592993 An14g04440 Aspergillus niger uncharacterized protein XP_059602303.1 1067258 R 5061 CDS An14g04450 84592994 complement(join(1067894..1067968,1068054..1068165,1068233..1068292,1068387..1068529,1068677..1068756,1069008..1069099,1069146..1069232,1069592..1069923)) I 1 NT_166529.1 hypothetical protein 1069923 84592994 An14g04450 Aspergillus niger hypothetical protein XP_059602304.1 1067894 R 5061 CDS An14g04460 84592995 join(1070436..1070477,1070548..1070652) I 1 NT_166529.1 Title: questionable ORF; uncharacterized protein 1070652 84592995 An14g04460 Aspergillus niger uncharacterized protein XP_059602305.1 1070436 D 5061 CDS An14g04470 84592996 join(1070720..1070801,1070903..1071087,1071123..1071373,1071472..1071541) I 1 NT_166529.1 hypothetical protein 1071541 84592996 An14g04470 Aspergillus niger hypothetical protein XP_059602306.1 1070720 D 5061 CDS An14g04480 4987305 join(1071594..1071779,1071847..1071984,1072179..1072313) I 1 NT_166529.1 hypothetical protein 1072313 4987305 An14g04480 Aspergillus niger hypothetical protein XP_001401072.3 1071594 D 5061 CDS An14g04490 4987306 1072468..1073157 I 1 NT_166529.1 Title: weak similarity to hypothetical protein AF1318 - Archaeoglobus fulgidus; uncharacterized protein 1073157 4987306 An14g04490 Aspergillus niger uncharacterized protein XP_001401073.1 1072468 D 5061 CDS An14g04500 84592997 1073431..1074543 I 1 NT_166529.1 hypothetical protein 1074543 84592997 An14g04500 Aspergillus niger hypothetical protein XP_059602307.1 1073431 D 5061 CDS An14g04510 84592998 complement(1075253..1076095) I 1 NT_166529.1 Title: similarity to essential protein #47 WO2003076464-A2 - Aspergillus fumigatus; uncharacterized protein 1076095 84592998 An14g04510 Aspergillus niger uncharacterized protein XP_059602308.1 1075253 R 5061 CDS An14g04520 4987309 join(1077008..1077021,1077101..1078499,1078621..1078787,1078892..1079002,1079156..1079241,1079490..1079577,1079695..1079827) I 1 NT_166529.1 hypothetical protein 1079827 4987309 An14g04520 Aspergillus niger hypothetical protein XP_001401076.3 1077008 D 5061 CDS An14g04530 4987310 join(1079869..1080123,1080180..1080839) I 1 NT_166529.1 Function: ORF4 is part of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor but it does not seem to be involved directly in actinorhodin biosynthesis.; Remark: also similar to human patent PATENTPROT:Y14147.; Title: similarity to hypothetical protein actVA-ORF4 - Streptomyces coelicolor; See PMID 1766437; See PMID 7929165; uncharacterized protein 1080839 4987310 An14g04530 Aspergillus niger uncharacterized protein XP_001401077.1 1079869 D 5061 CDS An14g04540 84592999 join(1081145..1081330,1081517..1081756) I 1 NT_166529.1 hypothetical protein 1081756 84592999 An14g04540 Aspergillus niger hypothetical protein XP_059602309.1 1081145 D 5061 CDS An14g04550 84593000 join(1083266..1083373,1083461..1083517,1083749..1083808) I 1 NT_166529.1 hypothetical protein 1083808 84593000 An14g04550 Aspergillus niger hypothetical protein XP_059602310.1 1083266 D 5061 CDS An14g04560 4987313 complement(join(1084179..1084835,1084901..1085822,1085904..1086169)) I 1 NT_166529.1 Title: strong similarity to hypothetical protein B15I20.30 - Neurospora crassa; uncharacterized protein 1086169 4987313 An14g04560 Aspergillus niger uncharacterized protein XP_001401080.1 1084179 R 5061 CDS An14g04570 84593001 complement(1086400..1086684) I 1 NT_166529.1 hypothetical protein 1086684 84593001 An14g04570 Aspergillus niger hypothetical protein XP_059602311.1 1086400 R 5061 CDS An14g04580 84593002 join(1087024..1087074,1087187..1087378) I 1 NT_166529.1 hypothetical protein 1087378 84593002 An14g04580 Aspergillus niger hypothetical protein XP_059602312.1 1087024 D 5061 CDS An14g04590 4987316 complement(join(1087436..1089302,1089448..1090754)) I 1 NT_166529.1 Similarity: KCS1 of S. cerevisiae is similar to the basic leucine zipper family of transcription factors.; Title: strong similarity to transcription factor Kcs1 - Saccharomyces cerevisiae; uncharacterized protein 1090754 4987316 An14g04590 Aspergillus niger uncharacterized protein XP_059602313.1 1087436 R 5061 CDS An14g04600 84593003 complement(join(1092559..1092652,1092745..1092921,1093087..1093158,1093270..1093376,1093458..1093601,1093685..1093885)) I 1 NT_166529.1 hypothetical protein 1093885 84593003 An14g04600 Aspergillus niger hypothetical protein XP_059602314.1 1092559 R 5061 CDS An14g04610 84593004 complement(join(1094000..1094041,1094100..>1094252)) I 1 NT_166529.1 hypothetical protein [truncated ORF] 1094252 84593004 An14g04610 Aspergillus niger hypothetical protein [truncated ORF] XP_059602315.1 1094000 R 5061 CDS An14g04620 4987319 1096275..1097798 I 1 NT_166529.1 Title: strong similarity to hypothetical protein EAA35125.1 - Neurospora crassa; uncharacterized protein 1097798 4987319 An14g04620 Aspergillus niger uncharacterized protein XP_001401086.3 1096275 D 5061 CDS An14g04630 4987320 complement(join(1099780..1100484,1100580..1100899,1101113..1101119)) I 1 NT_166529.1 Title: weak similarity to hypothetical protein encoded by An01g07840 - Aspergillus niger; uncharacterized protein 1101119 4987320 An14g04630 Aspergillus niger uncharacterized protein XP_001401087.3 1099780 R 5061 CDS An14g04640 4987321 join(1103629..1104406,1104470..1104705) I 1 NT_166529.1 Title: strong similarity to hypothetical protein EAA58284.1 - Aspergillus nidulans; uncharacterized protein 1104705 4987321 An14g04640 Aspergillus niger uncharacterized protein XP_001401088.1 1103629 D 5061 CDS An14g04650 4987322 join(1105690..1105798,1105892..1108089) I 1 NT_166529.1 Function: A. nidulans palH is one of the components of the ambient pH signal transduction pathway (Pal pathway).; Title: strong similarity to pH signal transductions protein palH - Aspergillus nidulans; See PMID 10476033; See PMID 10821185; uncharacterized protein 1108089 4987322 An14g04650 Aspergillus niger uncharacterized protein XP_001401089.1 1105690 D 5061 CDS An14g04660 4987323 join(1108944..1108947,1109006..1109136,1109196..1109918) I 1 NT_166529.1 Title: similarity to hypothetical conserved protein PA2839 - Pseudomonas aeruginosa; uncharacterized protein 1109918 4987323 An14g04660 Aspergillus niger uncharacterized protein XP_001401090.1 1108944 D 5061 CDS An14g04670 4987324 join(1110806..1110916,1110986..1112749) I 1 NT_166529.1 Title: weak similarity to hypothetical protein encoded by An01g13670 - Aspergillus niger [putative sequencing error]; putative sequencing error; uncharacterized protein 1112749 4987324 An14g04670 Aspergillus niger uncharacterized protein XP_059602316.1 1110806 D 5061 CDS An14g04680 4987325 join(1114490..1115011,1115138..1116327,1116522..1117776) I 1 NT_166529.1 hypothetical protein 1117776 4987325 An14g04680 Aspergillus niger hypothetical protein XP_001401092.3 1114490 D 5061 CDS An14g04710 4987328 complement(join(1119415..1119752,1119812..1120060,1120113..1120390,1120442..1120761)) I 1 NT_166529.1 Alternative name: proctase B; Catalytic activity: pepA generally favours hydrophobic residues in P1 and P1', but also accepts Lys in P1, which leads to activation of trypsinogen.; Function: pepA has properties of pepsin-type aspartic proteinases and hydrolyses proteins with broad specificity.; Gene-ID: pepA; Mapping: pepA from A. niger is mapped to chromosome I; see list from DSM, PUBMED 9309173.; Remark: A. niger macrosporus excretes two types of acid endopeptidases, the major one is proctase B/aspergillopepsin I, and the minor one is proctase A.; extracellular/secretion proteins; aspartic proteinase aspergillopepsin I pepA-Aspergillus niger 1120761 pepA 4987328 pepA Aspergillus niger aspartic proteinase aspergillopepsin I pepA-Aspergillus niger XP_001401093.1 1119415 R 5061 CDS An14g04720 4987329 complement(join(1121855..1122616,1122669..1122967,1123108..1123869,1123913..1125010,1125109..1125313)) I 1 NT_166529.1 Function: S. cerevisiae ARO80 is involved in positive regulation of aromatic amino acid synthesis through positive regulation of ARO9 and ARO10/YDR380W.; Remark: S. cerevisiae ARO80 is a member of the Zn2Cys6 transcription factor family.; Remark: the systematic name for S. cerevisiae ARO80 is YDR421w.; Title: similarity to transcription factor Aro80 -Saccharomyces cerevisiae; See PMID 10207060; uncharacterized protein 1125313 4987329 An14g04720 Aspergillus niger uncharacterized protein XP_059602317.1 1121855 R 5061 CDS An14g04730 4987330 complement(join(1126427..1128184,1128299..1128361)) I 1 NT_166529.1 Function: disruption of human UVRAG gives rise to developmental defects including complex cyanotic heart defects, altered lung lobation, symmetric liver, and abnormally lobulated spleen.; Function: human UVRAG is able to complement partially the ultraviolet sensitivity of a xeroderma pigmentosum cell line.; Similarity: the strongest similarity of the ORF is to a hypothetical p63 related protein of Neurospora crassa.; Title: strong similarity to UVRAG - Homo sapiens; See PMID 9169138; See PMID 10798355; uncharacterized protein 1128361 4987330 An14g04730 Aspergillus niger uncharacterized protein XP_059602318.1 1126427 R 5061 CDS An14g04740 4987331 join(1128856..1129134,1129241..1130014) I 1 NT_166529.1 Title: weak similarity to hypothetical protein SPBC18H10.17c - Schizosaccharomyces pombe; mitochondrial 54S ribosomal protein mL67 1130014 4987331 An14g04740 Aspergillus niger mitochondrial 54S ribosomal protein mL67 XP_001401096.1 1128856 D 5061 CDS An14g04750 4987332 complement(join(1130171..1130254,1130366..1130765,1130839..1130942,1131045..1131193,1131277..1131397)) I 1 NT_166529.1 Title: similarity to hypothetical protein AAM35689.1 - Xanthomonas axonopodis; uncharacterized protein 1131397 4987332 An14g04750 Aspergillus niger uncharacterized protein XP_059602319.1 1130171 R 5061 CDS An14g04760 4987333 join(1132902..1133035,1133101..1134361) I 1 NT_166529.1 Function: S. chinensis FAR is an alcohol-forming fatty acyl-coenzyme A reductase required for the production of esters of long-chain alcohols and fatty acids (waxes).; Title: similarity to acyl CoA reductase FAR -Simmondsia chinensis; See PMID 10712526; uncharacterized protein 1134361 4987333 An14g04760 Aspergillus niger uncharacterized protein XP_001401098.3 1132902 D 5061 CDS An14g04765 84593005 complement(1134623..1134823) I 1 NT_166529.1 hypothetical protein 1134823 84593005 An14g04765 Aspergillus niger hypothetical protein XP_059602320.1 1134623 R 5061 CDS An14g04770 4987335 complement(join(1135253..1135696,1135757..1136466,1136497..1137043)) I 1 NT_166529.1 Function: S. cerevisiae Ptc1 inactivates the HOG pathway by dephosphorylating the mitogen-activated protein kinase Hog1.; Function: S. cerevisiae Ptc1 negatively affects PBS2 action, regulating cell wall beta-glucan assembly.; Remark: Ptc1 of S. pombe is a type 2C Ser/Thr phosphatase, one of the three major families of structurally unrelated eukaryotic protein phosphatases.; Title: strong similarity to phosphoprotein phosphatase 2C ptc1p - Schizosaccharomyces pombe; See PMID 7565587; See PMID 8196617; See PMID 11113180; uncharacterized protein 1137043 4987335 An14g04770 Aspergillus niger uncharacterized protein XP_059602321.1 1135253 R 5061 CDS An14g04780 84593006 join(1137522..1137556,1137628..1137701,1137790..1137834,1137933..1138096) I 1 NT_166529.1 Similarity: similarity is from predicted A. niger protein to C-terminus of mouse, rat and human hairless,which are all about 1000 aa longer.; Title: weak similarity to transcription factor hairless - Mus musculus [putative sequencing error]; putative sequencing error; See PMID 8052649; uncharacterized protein 1138096 84593006 An14g04780 Aspergillus niger uncharacterized protein XP_059602322.1 1137522 D 5061 CDS An14g04790 4987337 complement(join(1138428..1138938,1139002..1140215,1140308..1140324,1140390..1140399)) I 1 NT_166529.1 Catalytic activity: PPiases catalyse the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.; Function: PPiases accelerate the folding of proteins.; Similarity: S. pombe SPAC21E11. 05C belongs to the cyclopholin family of prolyl isomerases, the other two PPI families are, FK506-binding proteins (FKBPs) and parvulins.; Title: strong similarity to peptidyl-prolyl cis-trans isomerase SPAC21E11.05C - Schizosaccharomyces pombe; See PMID 10424896; See PMID 2204030; uncharacterized protein 1140399 4987337 An14g04790 Aspergillus niger uncharacterized protein XP_001401102.1 1138428 R 5061 CDS An14g04800 4987338 complement(join(1141064..1142916,1143003..1143117)) I 1 NT_166529.1 Title: strong similarity to protein SEQ ID 2451 from patent EP1258494-A1 - Saccharomyces cerevisiae; uncharacterized protein 1143117 4987338 An14g04800 Aspergillus niger uncharacterized protein XP_059602323.1 1141064 R 5061 CDS An14g04810 84593007 complement(join(1143573..1143735,1143928..1143962,1144115..1144156)) I 1 NT_166529.1 Remark: the predicted ORF is only 79 amino acids long and contains relatively long introns.; hypothetical protein 1144156 84593007 An14g04810 Aspergillus niger hypothetical protein XP_059602324.1 1143573 R 5061 CDS An14g04820 84593008 join(1145455..1145895,1146148..1146206,1146448..1146536,1146652..1146659) I 1 NT_166529.1 Remark: the predicted ORF contains relatively long introns.; hypothetical protein 1146659 84593008 An14g04820 Aspergillus niger hypothetical protein XP_059602325.1 1145455 D 5061 CDS An14g04830 4987341 complement(join(1146892..1147753,1147823..1148241,1148296..1149417)) I 1 NT_166529.1 Function: S. cerevisiae Pif1 is a 5'-to-3' DNA helicase.; Function: it has been proposed that S. cerevisiae Pif1p-mediated inhibition of telomerase promotes genetic stability by suppressing telomerase-mediated healing of double-strand breaks.; Function: mutations in S. cerevisiae pif1 cause telomere lengthening and a large increase in the formation rate of new telomeres.; Title: strong similarity to helicase Pif1 -Saccharomyces cerevisiae; See PMID 10693764; See PMID 10926538; uncharacterized protein 1149417 4987341 An14g04830 Aspergillus niger uncharacterized protein XP_001401106.1 1146892 R 5061 CDS An14g04840 4987342 complement(1149820..1150572) I 1 NT_166529.1 Title: similarity to hypothetical O-methyl transferase EncK - Streptomyces maritimus; uncharacterized protein 1150572 4987342 An14g04840 Aspergillus niger uncharacterized protein XP_001401107.1 1149820 R 5061 CDS An14g04850 84593009 join(1151370..1151395,1151545..1157128) I 1 NT_166529.1 Catalytic activity: polyketide synthases are multifunctional enzymes, containing oxidoreductase,transferase and dehydratase activity; some of the typical domains present in polyketide synthases are recognized in the predicted ORF.; Function: pimS2 of S. natalensis is involved in the biosynthesis of the polyene macrolide pimaricin, important in the food industry as a preservative to prevent mould contamination of foods.; Pathway: polyketides are generated from acetate by a pathway similar to the fatty acid metabolism, where some reduction or dehydratation reactions can be suppressed at specific biosynthetic steps, resulting in a much wider range of products, constituting a large family of often biologically active secondary metabolites.; Similarity: the predicted ORF shows strong similarity to different fungal polyketide synthases.; Title: strong similarity to pimaricin polyketide synthase pimS2 - Streptomyces natalensis; See PMID 11094342; uncharacterized protein 1157128 84593009 An14g04850 Aspergillus niger uncharacterized protein XP_059602326.1 1151370 D 5061 CDS An14g04860 4987344 join(1157433..1157461,1157494..1157578,1157665..1157941,1158004..1158626,1158676..1158952,1158999..1159079,1159124..1160139) I 1 NT_166529.1 Complex: Rad4 of S. pombe may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis.; Function: Rad4 of S. pombe is an essential component for DNA replication and also the checkpoint control system which couples S and M phases.; Title: strong similarity to S-M checkpoint control protein rad4p - Schizosaccharomyces pombe; nucleus; See PMID 8343962; See PMID 9268024; See PMID 1762905; uncharacterized protein 1160139 4987344 An14g04860 Aspergillus niger uncharacterized protein XP_059602327.1 1157433 D 5061 CDS An14g04870 4987345 complement(join(1161065..1161423,1161480..1162326,1162405..1163536,1163615..1163663,1163737..1164106)) I 1 NT_166529.1 Complex: FZO1 of S. cerevisiae is part of a larger protein complex of 800 kDa.; Function: FZO1 is a GTPase required for the biogenesis of functional mitochondria in S. cerevisiae.; Localization: FZO1 of S. cerevisiae is an integral protein of the mitochondrial outer membrane exposing its major part to the cytosol.; Remark: FZO1 of S. cerevisiae is also known as YBR179C.; Similarity: A. niger EST EMBLEST:BE759505 comprises the last exon and the probable 3'-UTR of the predicted gene.; Similarity: the N-terminal region of the predicted ORF shows no similarity to FZO1 of S. cerevisiae.; Title: strong similarity to fuzzy onions homolog Fzo1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9230308; See PMID 9685359; See PMID 9891785; uncharacterized protein 1164106 4987345 An14g04870 Aspergillus niger uncharacterized protein XP_059602328.1 1161065 R 5061 CDS An14g04880 4987346 join(1164494..1164499,1164611..1164825,1164896..1164956,1165015..1165296,1165383..1165478) I 1 NT_166529.1 Function: DID4 (Doa4-independent degradation gene n. 4) of S. cerevisiae encode a component of the vacuolar protein-sorting (Vps) pathway.; Function: in particular, DID4 of S. cerevisiae belongs to the class E of Vps factors, which function in the maturation of a late endosome/prevacuolar compartment into multivesicular bodies that then fuse with the vacuole.; Remark: DID4 of S. cerevisiae is also known as YKL002W.; Title: strong similarity to class E vacuolar-protein sorting factor Did4 - Saccharomyces cerevisiae; See PMID 11029042; uncharacterized protein 1165478 4987346 An14g04880 Aspergillus niger uncharacterized protein XP_059602329.1 1164494 D 5061 CDS An14g04890 4987347 complement(join(1165802..1166958,1167015..1167044,1167102..1167552)) I 1 NT_166529.1 Function: the ability of AFC1 of A. thaliana of restoring the functionality of a compromised signal transduction pathway, was experimentally verified in a mutant strain of S. cerevisiae.; Similarity: the main feature of the predicted ORF is the presence of different structural regions common to various protein kinases.; Similarity: the predicted ORF contains three protein kinase domains and a leucine zipper motiv, usually involved in protein-protein interaction especially in gene regulatory proteins.; Similarity: the predicted ORF is also similar to human calcium-calmodulin dependent protein kinase I.; Title: similarity to protein kinase AFC1 -Arabidopsis thaliana; See PMID 7641687; See PMID 7991592; uncharacterized protein 1167552 4987347 An14g04890 Aspergillus niger uncharacterized protein XP_001401112.1 1165802 R 5061 CDS An14g04900 84593010 join(1168260..1168545,1168588..1168616) I 1 NT_166529.1 hypothetical protein 1168616 84593010 An14g04900 Aspergillus niger hypothetical protein XP_059602330.1 1168260 D 5061 CDS An14g04910 4987349 1169771..1171738 I 1 NT_166529.1 Similarity: the similarity is limited to the central part of the molecules and is mainly due to repetitive amino acid stretches.; Title: weak similarity to GABA-A receptor epsilon-like subunit epsilon - Rattus norvegicus; See PMID 10804200; uncharacterized protein 1171738 4987349 An14g04910 Aspergillus niger uncharacterized protein XP_001401114.1 1169771 D 5061 CDS An14g04920 4987350 join(1172509..1172546,1172655..1172934,1172994..1173068,1173184..1173296,1173356..1173570,1173628..1173656) I 1 NT_166529.1 Catalytic activity: triose-phosphate isomerase catalyzes the reversible isomerization: D-glyceraldehyde 3-phosphate <=> dihydroxy-acetone phosphate.; Complex: triose-phosphate isomerase is a homodimer.; Gene-ID: tpiA; Pathway: triose-phosphate isomerase plays an important role in several metabolic pathways, starting from the glycolysis.; cytoplasm; See PMID 6762366; See PMID 10916682; See PMID 11257493; See PMID 3521890; triose-phosphate-isomerase tpiA from patent WO8704464-A-Aspergillus niger 1173656 tpiA 4987350 tpiA Aspergillus niger triose-phosphate-isomerase tpiA from patent WO8704464-A-Aspergillus niger XP_001401115.1 1172509 D 5061 CDS An14g04930 4987351 complement(join(1173796..1173885,1174129..1174570,1174631..1175306,1175370..1175466)) I 1 NT_166529.1 Function: MDM10 of P. anserina is implicated in the maintenance of mitochondrial morphology and distribution.; Phenotype: MDM10 mutants in P. anserina accumulate specific deleted mitochondrial genomes during senescence.; Title: strong similarity to mitochondrial outer membrane protein MDM10 - Podospora anserina; localisation:mitochondrion; See PMID 9343397; uncharacterized protein 1175466 4987351 An14g04930 Aspergillus niger uncharacterized protein XP_059602331.1 1173796 R 5061 CDS An14g04940 4987352 join(1175861..1176054,1176146..1176377,1176414..1176692) I 1 NT_166529.1 Phenotype: S. cerevisiae MRT4 null mutants are viable, are not defective in protein synthesis, but have defects in mRNA decay and growth.; Remark: MRT4 of S. cerevisiae is also known as YKL009W.; Similarity: the predicted ORF contains, indeed,structural characteristics common to ribosomal or RNA-binding proteins.; Similarity: the predicted ORF shows strong similarity to a plenty of putative proteins annotated as acidic ribosomal protein P0; comparison to the validated P0 proteins, and especially the lack of the typical acidic C-terminus, suggest caution in accepting such a classification.; Similarity: the stronger described homologue, MRT4 of S. cerevisiae, is more likely involved in RNA degradation than in protein synthesis, suggesting it is not a ribosome component.; Title: strong similarity to mRNA turnover 4 protein Mrt4 - Saccharomyces cerevisiae; See PMID 10471698; See PMID 3323886; uncharacterized protein 1176692 4987352 An14g04940 Aspergillus niger uncharacterized protein XP_059602332.1 1175861 D 5061 CDS An14g04950 4987353 complement(join(1177790..1178472,1178575..1178671,1178729..1178856,1178916..1179177)) I 1 NT_166529.1 Complex: snRNP27D of D. melanogaster is a component of the U1 small nuclear ribonucleoprotein (snRNP) complex.; Function: U1 snRNP is required at an early stage during assembly of the spliceosome, the dynamic RNP complex that performs nuclear pre-mRNA splicing.; Similarity: activity and composition of the U1 snRNP are highly conserved in all metazoans.; Title: strong similarity to 70K U1 small nuclear ribonucleoprotein snRNP27D - Drosophila melanogaster; nucleus; See PMID 1692955; See PMID 11333025; uncharacterized protein 1179177 4987353 An14g04950 Aspergillus niger uncharacterized protein XP_001401118.1 1177790 R 5061 CDS An14g04960 4987354 join(1179502..1179540,1179600..1179682,1179749..1180040) I 1 NT_166529.1 Similarity: the predicted gene is nearly identical to A. niger EST EMBLEST:BE759452; another A. niger EST (EMBLEST:BE759721) likely corresponds to the polyadenylation signal and the 3'-UTR of the gene.; Title: strong similarity to protein fragment SEQ ID NO:40372 from patent EP1033405-A2 - Zea mays; mitochondrial 54S ribosomal protein mL43 1180040 4987354 An14g04960 Aspergillus niger mitochondrial 54S ribosomal protein mL43 XP_001401119.1 1179502 D 5061 CDS An14g04970 4987355 complement(join(1180549..1181571,1181683..1181730)) I 1 NT_166529.1 Similarity: most BLASTP hits are due to polyproline stretches.; Title: weak similarity to hypothetical zinc-finger protein SPAC19A8.10 - Schizosaccharomyces pombe; uncharacterized protein 1181730 4987355 An14g04970 Aspergillus niger uncharacterized protein XP_059602333.1 1180549 R 5061 CDS An14g04980 4987356 complement(join(1182507..1182970,1183031..1183494,1183549..1183993,1184050..1184094,1184154..1184166)) I 1 NT_166529.1 Complex: PRP19 of S. cerevisiae is a component of the spliceosome, the multiprotein complex responsible for pre-mRNA splicing; within the complex, PRP19 itself is in an oligomeric form.; Function: PRP19 of S. cerevisiae is also involved in an error-prone repair pathway which relies on a recombinational mechanism, comparable to the E. coli SOS repair pathway.; Phenotype: S. cerevisiae null mutant for PRP19 is inviable,other allelic variants are sensitive to DNA mutagens, unable to perform induced mitotic recombination and sporulation.; Remark: PRP19 of S. cerevisiae is also known as PSO4 or YLL036C.; Title: strong similarity to splicing protein Prp19 -Saccharomyces cerevisiae; nucleus; See PMID 7680101; See PMID 8194532; See PMID 8441419; See PMID 2671661; See PMID 2671705; uncharacterized protein 1184166 4987356 An14g04980 Aspergillus niger uncharacterized protein XP_001401121.1 1182507 R 5061 CDS An14g04990 4987357 join(1184588..1184618,1184675..1185132) I 1 NT_166529.1 Similarity: the similarity to fkbp39 of D. melanogaster is mainly due to the acidic region present in the fly protein.; Title: weak similarity to FK506-binding 39k protein fkbp39 - Drosophila melanogaster; See PMID 7538962; uncharacterized protein 1185132 4987357 An14g04990 Aspergillus niger uncharacterized protein XP_001401122.1 1184588 D 5061 CDS An14g05000 4987358 join(1185608..1185634,1185738..1185758,1185834..1186374,1186417..1186747,1186797..1188341,1188458..1188735,1188805..1189184) I 1 NT_166529.1 Function: Ria1 of S. cerevisiae is involved in the biogenesis of the 60S subunit of the ribosome.; Remark: Ria1 of S. cerevisiae is also known as YNL163C.; Remark: reference is: Becam, A-M, Nasr, F, Racki, WJ, Zagulski, M, Herbert, CJ (2001) Ria1p (Ynl163c), a protein similar to elongation factors 2, is involved in the biogenesis of the 60S subunit of the ribosome in S. cerevisiae. Mol. Gen. Genet., in press.; Similarity: nevertheless the stronger similarity to Ria1, which characterization was submitted for publication,suggests that the function of the predicted ORF could be different.; Similarity: the predicted ORF displays strong similarity to several putative proteins all annotated as translation elongation factor 2; it shares many structural features with this protein family, comprised the GTP-binding domains.; Title: strong similarity to protein Ria1 -Saccharomyces cerevisiae; uncharacterized protein 1189184 4987358 An14g05000 Aspergillus niger uncharacterized protein XP_059602334.1 1185608 D 5061 CDS An14g05010 4987359 complement(join(1189993..1190292,1190395..1190482,1190522..1190748)) I 1 NT_166529.1 Complex: CSL4 of S. cerevisiae is an essential component of the exosome, a conserved complex of multiple 3'-to-5' exonucleases required for diverse RNA processing events, such as mRNA degradation and rRNA processing.; Phenotype: null mutation of CSL4 in S. cerevisiae is lethal.; Remark: CSL4 of S. cerevisiae is also known as SKI4 or YNL232W.; Similarity: the N-terminal part of the predicted ORF has only marignal similarity to CSL4 of S. cerevisiae.; Similarity: the predicted ORF shows stronger similarity to putative proteins found in yeasts, fungi and mammals.; Title: strong similarity to 3-5 exoribonuclease Csl4 - Saccharomyces cerevisiae; See PMID 9583939; See PMID 10087930; See PMID 11027292; uncharacterized protein 1190748 4987359 An14g05010 Aspergillus niger uncharacterized protein XP_059602335.1 1189993 R 5061 CDS An14g05020 4987360 complement(join(1191424..1191749,1191815..1192564,1192619..1192864,1192919..1193032,1193095..1193215,1193298..1193471)) I 1 NT_166529.1 Complex: Vac8 of S. cerevisiae interacts with Apg13.; Function: VAC8 of S. cerevisiae functions in both vacuole inheritance between mother and daughter cells, and protein targeting from the cytoplasm to vacuole.; Localization: VAC8 of S. cerevisiae is found on the vacuole membrane.; Similarity: armadillo (Arm) repeats are thought to mediate protein-protein interactions, and many Arm proteins have multiple functions.; Title: strong similarity to armadillo repeat-containing protein Vac8 - Saccharomyces cerevisiae; vacuole; See PMID 9490720; See PMID 9664035; See PMID 10837477; See PMID 10873824; uncharacterized protein 1193471 4987360 An14g05020 Aspergillus niger uncharacterized protein XP_001401125.1 1191424 R 5061 CDS An14g05030 84593011 join(1193598..1193792,1193871..1193956,1194073..1194156,1194199..1194310) I 1 NT_166529.1 Title: weak similarity to hypothetical membrane protein SCK20.08 - Streptomyces coelicolor; uncharacterized protein 1194310 84593011 An14g05030 Aspergillus niger uncharacterized protein XP_059602336.1 1193598 D 5061 CDS An14g05040 84593012 join(1195932..1196105,1196202..1196273) I 1 NT_166529.1 hypothetical protein 1196273 84593012 An14g05040 Aspergillus niger hypothetical protein XP_059602337.1 1195932 D 5061 CDS An14g05050 4987363 join(1197634..1198709,1198771..1198867,1198931..1199524) I 1 NT_166529.1 Function: dma1 of S. pombe is a component of the spindle assembly checkpoint, required to prevent septum formation and premature exit from mitosis if spindle function is impaired.; Similarity: the predicted ORF contains an FHA (Forkhead-associated) domain, which is a phosphopeptide binding motif; the FHA domain is a putative nuclear signalling domain found in a variety of otherwise unrelated proteins.; Similarity: the similarity to dma1 of S. pombe is limited to the C-terminal half of the predicted ORF; the C-terminal half is very rich of low-complexity,serine-containing repeats, producing many alignments with proteophosphoglycans.; Title: strong similarity to defective in mitotic arrest dma1p - Schizosaccharomyces pombe; See PMID 8978687; uncharacterized protein 1199524 4987363 An14g05050 Aspergillus niger uncharacterized protein XP_001401128.1 1197634 D 5061 CDS An14g05060 84593013 complement(join(1200195..1200330,1200386..1200402)) I 1 NT_166529.1 hypothetical protein 1200402 84593013 An14g05060 Aspergillus niger hypothetical protein XP_059602338.1 1200195 R 5061 CDS An14g05070 4987365 complement(join(1201187..1201563,1201622..1201942,1201997..1202147)) I 1 NT_166529.1 Title: similarity to hypothetical protein X4G11.070 - Neurospora crassa; uncharacterized protein 1202147 4987365 An14g05070 Aspergillus niger uncharacterized protein XP_001401130.1 1201187 R 5061 CDS An14g05080 84593014 complement(join(1203682..1204064,1204150..1204332,1204416..1204680,1204988..1205008)) I 1 NT_166529.1 Function: many ankyrin repeat regions are known to function as protein-protein interaction domains.; Remark: closest manual BLASTP homologue: SWISSPROT:ANK1_HUMAN.; Similarity: ankyrin repeats (ANK) are tandemly repeated modules of about 33 amino acids, that occur in a large number of functionally diverse proteins mainly from eukaryotes.; Similarity: the predicted ORF shows similarity also to the ZU5 domain present in ZO-1 and Unc5-like netrin receptors, which function remains unknown.; Similarity: the similarity to ankyrin of H. sapiens and other proteins is mainly due to the presence of two ankyrin repeats.; Title: weak similarity to ankyrin (variant 2.1) -Homo sapiens; See PMID 1689849; uncharacterized protein 1205008 84593014 An14g05080 Aspergillus niger uncharacterized protein XP_059602339.1 1203682 R 5061 CDS An14g05090 84593015 join(1205964..1206016,1206063..1206126) I 1 NT_166529.1 Similarity: BLASTP identifies a stretch of similarity to D. melanogaster genomic fragment CG6456; there is no sufficient reason to consider such a similarity significant.; hypothetical protein 1206126 84593015 An14g05090 Aspergillus niger hypothetical protein XP_059602340.1 1205964 D 5061 CDS An14g05100 4987368 join(1206836..1206966,1207036..1207177,1207236..1207777,1207836..1208220) I 1 NT_166529.1 Title: strong similarity to hypothetical protein alr2987 - Nostoc sp.; uncharacterized protein 1208220 4987368 An14g05100 Aspergillus niger uncharacterized protein XP_001401133.1 1206836 D 5061 CDS An14g05110 4987369 1208664..1209200 I 1 NT_166529.1 Similarity: the predicted ORF contains an EF-hand,the most common domain responsible for calcium binding in proteins like calmodulin, myosin regulatory light chains,parvalbumins, troponins C, and neuronal calcium sensors.; Title: weak similarity to hypothetical protein AT4g01140 - Arabidopsis thaliana; uncharacterized protein 1209200 4987369 An14g05110 Aspergillus niger uncharacterized protein XP_001401134.1 1208664 D 5061 CDS An14g05120 4987370 complement(join(1209667..1209883,1209941..1210095,1210152..1210313,1210367..1210480,1210533..1210682,1210737..1210886,1210943..1211089)) I 1 NT_166529.1 Function: MoxR is a poorly characterized bacterial protein which may be involved in the regulation of formation of active methanol dehydrogenase.; Similarity: the predicted ORF shows weak similarity to many putative proteins classified as MoxR-like ATPases.; Title: strong similarity to hypothetical conserved protein 17E5.290 - Neurospora crassa; uncharacterized protein 1211089 4987370 An14g05120 Aspergillus niger uncharacterized protein XP_001401135.1 1209667 R 5061 CDS An14g05130 4987371 join(1211339..1211483,1211540..1211646,1211692..1211820,1211870..1212458,1212508..1213778,1213835..1214083) I 1 NT_166529.1 Complex: VPS16 of S. cerevisiae is a component of the so called class C Vps complex, required for vacuolar protein sorting and morphology.; Function: VPS16 of S. cerevisiae is required for vacuolar protein sorting and vacuolar biogenesis and stability.; Phenotype: S. cerevisiae VPS16 mutants have pleiotropic defects in vacuolar morphology and vacuolar protein targeting.; Title: strong similarity to vacuolar protein sorting-associated protein Vps16 - Saccharomyces cerevisiae; vacuole; See PMID 3062374; See PMID 8444873; See PMID 9362071; See PMID 1526998; uncharacterized protein 1214083 4987371 An14g05130 Aspergillus niger uncharacterized protein XP_001401136.1 1211339 D 5061 CDS An14g05140 4987372 complement(join(1214136..1214336,1214397..1214689,1214763..1214778)) I 1 NT_166529.1 Phenotype: ECM1 mutation in S. cerevisiae causes perturbation of the cell surface.; Remark: ECM1 of S. cerevisiae is also called YAL059w.; Title: similarity to Ecm1 - Saccharomyces cerevisiae; See PMID 9335584; uncharacterized protein 1214778 4987372 An14g05140 Aspergillus niger uncharacterized protein XP_001401137.1 1214136 R 5061 CDS An14g05150 4987373 1215054..1217045 I 1 NT_166529.1 Catalytic activity: ubiquitin C-terminal thiolester + H2O = ubiquitin + thiol.; Function: UBP1 of S. cerevisiae has an ATP-independent isopeptidase activity, cleaving at the carboxyl terminus of the ubiquitin moiety in natural or engineered linear fusion proteins, irrespective of their size or the presence of an amino-terminal extension to ubiquitin.; Similarity: UBP1 belongs to peptidase family C19; also known as family 2 of ubiquitin carboxyl-terminal hydrolases.; Similarity: although the predicted ORF is shorter than UBP1 of S. cerevisiae and the alignment contains several gaps, it shows consistent similarity to several ubiquitin-specific processing proteases.; Title: similarity to ubiquitin specific protease Ubp1 - Saccharomyces cerevisiae; See PMID 2050695; See PMID 8982460; See PMID 1429680; See PMID 10527495; uncharacterized protein 1217045 4987373 An14g05150 Aspergillus niger uncharacterized protein XP_001401138.1 1215054 D 5061 CDS An14g05160 4987374 complement(join(1217434..1217800,1217867..1218069,1218145..1218147)) I 1 NT_166529.1 Function: centrin is a ubiquitous component of centrosomes and mitotic spindle poles of diverse organisms and plays a role in centrosome separation at the time of mitosis.; Localization: human centrin is localized at the centrosome of interphase cells and redistributes to the region of the spindle poles during mitosis.; Similarity: in the predicted ORF the EF-hands are not well conserved; this fact might have important functional consequences.; Similarity: the human centrin sequence has four putative calcium-binding domains as defined by the EF-hand consensus.; Title: similarity to centrin - Homo sapiens; centrosome; See PMID 8175926; uncharacterized protein 1218147 4987374 An14g05160 Aspergillus niger uncharacterized protein XP_001401139.1 1217434 R 5061 CDS An14g05170 4987375 join(1218617..1218630,1218672..1218729,1218782..1219003,1219054..1220538) I 1 NT_166529.1 Function: thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide, and catalyzes dithiol-disulfide exchange reactions.; Similarity: the main feature of the predicted ORF,as well as of the very similar N. crassa hypothetical protein 17E5. 270, is to contain different structural domains, including the thioredoxin and the leucine zippers in the C-terminal region.; Similarity: the similarity to chicken thioredoxin and similar proteins of other species is limited to a single domain of the predicted ORF.; Title: similarity to thioredoxin - Gallus gallus; See PMID 2838473; uncharacterized protein 1220538 4987375 An14g05170 Aspergillus niger uncharacterized protein XP_059602341.1 1218617 D 5061 CDS An14g05180 84593016 1222080..1222403 I 1 NT_166529.1 Title: weak similarity to hypothetical As-rel1 -Halocynthia roretzi; uncharacterized protein 1222403 84593016 An14g05180 Aspergillus niger uncharacterized protein XP_059602342.1 1222080 D 5061 CDS An14g05190 4987377 complement(1222731..1223360) I 1 NT_166529.1 Title: weak similarity to MLL - Fugu rubripes; See PMID 9681821; uncharacterized protein 1223360 4987377 An14g05190 Aspergillus niger uncharacterized protein XP_001401142.1 1222731 R 5061 CDS An14g05200 84593017 join(1223424..1223463,1223515..1223583,1223683..1223783,1223988..1224184,1224228..1224258,1224364..1224495) I 1 NT_166529.1 Title: questionable ORF; uncharacterized protein 1224495 84593017 An14g05200 Aspergillus niger uncharacterized protein XP_059602343.1 1223424 D 5061 CDS An14g05210 84593018 join(1225555..1225605,1225684..1225812) I 1 NT_166529.1 Title: weak similarity to protein fragment SEQ ID NO:24290 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 1225812 84593018 An14g05210 Aspergillus niger uncharacterized protein XP_059602344.1 1225555 D 5061 CDS An14g05220 84593019 complement(join(1227558..1227670,1227761..1227866,1227943..1228035,1228184..1228232,1228414..1228558,1228779..1228872,1228976..1229009,1229087..1229544)) I 1 NT_166529.1 Title: weak similarity to furin-like protein 1 Fur1 - Drosophila melanogaster; See PMID 8491178; uncharacterized protein 1229544 84593019 An14g05220 Aspergillus niger uncharacterized protein XP_059602345.1 1227558 R 5061 CDS An14g05230 84593020 join(1229876..1230122,1230225..1230256,1230308..1230373) I 1 NT_166529.1 hypothetical protein 1230373 84593020 An14g05230 Aspergillus niger hypothetical protein XP_059602346.1 1229876 D 5061 CDS An14g05240 84593021 complement(join(1230474..1230636,1231125..1231193,1231366..1231389,1231557..1231688,1231742..1231749,1232149..1232247)) I 1 NT_166529.1 Title: questionable ORF; uncharacterized protein 1232247 84593021 An14g05240 Aspergillus niger uncharacterized protein XP_059602347.1 1230474 R 5061 CDS An14g05250 4987383 join(1234888..1234921,1234966..1235681) I 1 NT_166529.1 Function: it is suggested that the ORFL15 protein of S. spinosa is involved in oxido-reduction during spinosyn biosynthesis.; Remark: Spinosyns are insecticidal microlides which are useful for the control of arachnids, nematodes and insects.; Similarity: SDR is a very large family of enzymes,most of which are known to be NAD- or NADP-dependent oxidoreductases with different specificities.; Similarity: the predicted ORF shows strong similarity to several hypothetical and described members of the short chain dehydrogenase (SDR) protein family.; Title: strong similarity to protein involved in spinosyn biosynthesis ORFL15 from patent WO9946387-A1 -Saccharopolyspora spinosa; uncharacterized protein 1235681 4987383 An14g05250 Aspergillus niger uncharacterized protein XP_001401148.1 1234888 D 5061 CDS An14g05260 4987384 join(1236019..1236309,1236368..1236544,1236632..1237932,1238071..1238491) I 1 NT_166529.1 Catalytic activity: ATP + L-cysteine + tRNA(cys) = AMP + pyrophosphate + L-cysteinyl-tRNA(cys).; Similarity: YNL247W of S. cerevisiae belongs to class-I aminoacyl-tRNA synthetase family.; Title: strong similarity to cysteine--tRNA ligase YNL247w - Saccharomyces cerevisiae; See PMID 7619074; See PMID 9523015; See PMID 11347887; uncharacterized protein 1238491 4987384 An14g05260 Aspergillus niger uncharacterized protein XP_059602348.1 1236019 D 5061 CDS An14g05270 84593022 join(1238736..1238766,1238976..1239605,1239660..1239841,1239890..1240036) I 1 NT_166529.1 hypothetical protein 1240036 84593022 An14g05270 Aspergillus niger hypothetical protein XP_059602349.1 1238736 D 5061 CDS An14g05280 4987386 join(1241323..1241816,1241874..1242126,1242283..1242465) I 1 NT_166529.1 hypothetical protein 1242465 4987386 An14g05280 Aspergillus niger hypothetical protein XP_059602350.1 1241323 D 5061 CDS An14g05290 4987387 join(1243033..1243204,1243257..1245400) I 1 NT_166529.1 Function: isp4 of S. pombe is a membrane oligopeptide transporter.; Remark: isp4 of S. pombe was originally identified by subtractive screening as gene induced during the sexual differentiation process.; Similarity: the predicted A. niger protein shows strong similarity to protein isp4 of S. pombe, which belongs to the OPT subfamily of transporters specific for small oligopeptides (from the C. albicans OPT1 gene).; Title: strong similarity to protein isp4p -Schizosaccharomyces pombe; plasma membrane; See PMID 7954893; See PMID 9643541; uncharacterized protein 1245400 4987387 An14g05290 Aspergillus niger uncharacterized protein XP_001401152.1 1243033 D 5061 CDS An14g05300 4987388 complement(join(1246059..1246061,1246114..1246381,1246438..1246508,1246565..1246729,1247755..1247784,1247841..1248059)) I 1 NT_166529.1 Complex: YRA1 of S. cerevisiae mediates nuclear export of mRNA by interacting with several other protein factors, like Mex67.; Function: YRA1 of S. cerevisiae is an mRNA-binding protein involved in the nuclear export of mRNA towards the cytoplasm.; Remark: although the gene structure looks strange,the strong similarity to known proteins justify the model.; Similarity: YRA1 S. cerevisiae belongs to the evolutionarily conserved REF (RNA and export factor binding proteins) family of hnRNP-like proteins.; Title: strong similarity to RNA annealing protein Yra1 - Saccharomyces cerevisiae; nucleus; See PMID 9149233; See PMID 10783248; See PMID 10786854; See PMID 11390651; uncharacterized protein 1248059 4987388 An14g05300 Aspergillus niger uncharacterized protein XP_001401153.1 1246059 R 5061 CDS An14g05310 4987389 complement(join(1249046..1249684,1249747..1249794)) I 1 NT_166529.1 Function: the S. cerevisiae homolog Did3p is a class E Vps factor, which function in the maturation of a late endosome/prevacuolar compartment into multivesicular bodies that then fuse with the vacuole.; Remark: DID3 of S. cerevisiae is also called YKL041w.; Remark: S. cerevisiae Did3p is probably involved in the ubiquitin-mediated maturation of multivesicular bodies.; Title: strong similarity to protein involved in vacuolar protein sorting Did3 - Saccharomyces cerevisiae; endosome; See PMID 9606181; See PMID 11029042; uncharacterized protein 1249794 4987389 An14g05310 Aspergillus niger uncharacterized protein XP_001401154.1 1249046 R 5061 CDS An14g05320 4987390 join(1250472..1250502,1250695..1251020,1251082..1251246,1251309..1251383) I 1 NT_166529.1 Function: WOS2 of S. pombe is a cochaperone protein that interacts with cdc2 in the control of the M-G1 transition.; Similarity: WOS2 of S. pombe belongs to the p23 / wos2 family.; Title: strong similarity to cell cycle regulator p21 protein wos2p - Schizosaccharomyces pombe; See PMID 10581266; uncharacterized protein 1251383 4987390 An14g05320 Aspergillus niger uncharacterized protein XP_001401155.1 1250472 D 5061 CDS An14g05330 4987391 join(1252424..1252483,1252546..1252563,1252670..1252996,1253024..1253220,1253280..1253709) I 1 NT_166529.1 Title: strong similarity to hypothetical protein YOR091w - Saccharomyces cerevisiae; uncharacterized protein 1253709 4987391 An14g05330 Aspergillus niger uncharacterized protein XP_059602351.1 1252424 D 5061 CDS An14g05340 4987392 join(1254664..1255055,1255126..1255211,1255292..1255971,1256149..1256216,1256262..1256304) I 1 NT_166529.1 Title: strong similarity to hypothetical protein BH0485 - Bacillus halodurans; uncharacterized protein 1256304 4987392 An14g05340 Aspergillus niger uncharacterized protein XP_059602352.1 1254664 D 5061 CDS An14g05350 4987393 complement(join(1257035..1257140,1257200..1257273,1257327..1257459,1257516..1258255,1258323..1258397,1258486..1258578)) I 1 NT_166529.1 Function: ayg1 of A. fumigatus has an unknown function, but it is contained in the gene cluster responsible for conidial pigmentation.; Phenotype: ayg1 null mutants of A. fumigatus have yellowish-green conidia.; Title: strong similarity to hypothetical yellowish-green 1 ayg1 - Aspergillus fumigatus; See PMID 10515939; uncharacterized protein 1258578 4987393 An14g05350 Aspergillus niger uncharacterized protein XP_001401158.1 1257035 R 5061 CDS An14g05360 84593023 join(1258730..1258884,1259005..1259083,1259275..1259610,1259699..1260052) I 1 NT_166529.1 hypothetical protein 1260052 84593023 An14g05360 Aspergillus niger hypothetical protein XP_059602353.1 1258730 D 5061 CDS An14g05370 4987395 join(1260177..1260512,1260574..1261673,1261691..1261898) I 1 NT_166529.1 Similarity: the predicted ORF shows very strong similarity to abr1 of A. fumigatus, a gene of the conidial pigmentation gene cluster; abr1 mutants have brown conidia,and the proposed function of abr1 is multicopper oxidase.; Title: strong similarity to cell surface ferroxidase precursor Fet3 - Saccharomyces cerevisiae; plasma membrane; See PMID 8599111; See PMID 9162052; See PMID 9325307; See PMID 9520490; See PMID 10515939; uncharacterized protein 1261898 4987395 An14g05370 Aspergillus niger uncharacterized protein XP_059602354.1 1260177 D 5061 CDS An14g05380 4987396 complement(join(1262334..1262767,1262821..1263517)) I 1 NT_166529.1 Catalytic activity: the D-amino acid oxidase catalyzes the reaction: D-Amino acid + H2O + O2 = 2-Oxo acid + NH3 + H2O2.; Catalytic activity: the D-amino acid oxidase has a wide specificity for D-amino acids, acting also on glycine.; Cofactor: D-amino acid oxidase is a flavoprotein (FAD is the cofactor).; Title: strong similarity to D-amino acid oxidase DAO1 - Trigonopsis variabilis; See PMID 9434346; uncharacterized protein 1263517 4987396 An14g05380 Aspergillus niger uncharacterized protein XP_059602355.1 1262334 R 5061 CDS An14g05390 4987397 complement(join(1264342..1264482,1264539..1264704,1264756..1264982,1265043..1265078)) I 1 NT_166529.1 Title: strong similarity to hypothetical protein CGI-35 - Homo sapiens; uncharacterized protein 1265078 4987397 An14g05390 Aspergillus niger uncharacterized protein XP_001401162.1 1264342 R 5061 CDS An14g05400 84593024 1267465..1267854 I 1 NT_166529.1 Title: weak similarity to proteinase inhibitor PID -Solanum tuberosum; See PMID 8069493; uncharacterized protein 1267854 84593024 An14g05400 Aspergillus niger uncharacterized protein XP_059602356.1 1267465 D 5061 CDS An14g05410 4987399 join(1268217..1268628,1268688..1268811,1268869..1269180,1269235..1270013,1270074..1273183) I 1 NT_166529.1 Similarity: A. niger EST EMBLEST:BE760323 corresponds to the 3' portion of the last exon and a fragment of the putative 3'-UTR of the gene.; Title: strong similarity to hypothetical protein CAD21189.1 - Neurospora crassa; uncharacterized protein 1273183 4987399 An14g05410 Aspergillus niger uncharacterized protein XP_001401164.1 1268217 D 5061 CDS An14g05420 4987400 complement(1273780..1275102) I 1 NT_166529.1 Title: weak similarity to hypothetical Ena-VASP-like protein - Homo sapiens; uncharacterized protein 1275102 4987400 An14g05420 Aspergillus niger uncharacterized protein XP_001401165.3 1273780 R 5061 CDS An14g05430 4987401 complement(join(1275392..1275481,1275551..1275854,1275927..1276222,1276327..1276374)) I 1 NT_166529.1 Similarity: SDR is a very large family of enzymes,most of which are known to be NAD- or NADP-dependent oxidoreductases with different specificities.; Similarity: the predicted ORF shows strong similarity to several hypothetical and described members of the short chain dehydrogenase (SDR) protein family.; Title: similarity to meso-2,3-butanediol dehydrogenase (D-acetoin forming) budC - Klebsiella pneumoniae; See PMID 10389264; See PMID 11169050; See PMID 11173520; See PMID 11375507; uncharacterized protein 1276374 4987401 An14g05430 Aspergillus niger uncharacterized protein XP_001401166.1 1275392 R 5061 CDS An14g05440 4987402 1277161..1278231 I 1 NT_166529.1 Title: strong similarity to hypothetical protein encoded by An11g07600 - Aspergillus niger; uncharacterized protein 1278231 4987402 An14g05440 Aspergillus niger uncharacterized protein XP_001401167.1 1277161 D 5061 CDS An14g05450 4987403 1278656..1279429 I 1 NT_166529.1 Title: strong similarity to hypothetical protein encoded by An08g11330 - Aspergillus niger; uncharacterized protein 1279429 4987403 An14g05450 Aspergillus niger uncharacterized protein XP_001401168.3 1278656 D 5061 CDS An14g05460 4987404 join(1280464..1280513,1280603..1280840,1280898..1281091,1281174..1281882) I 1 NT_166529.1 Title: similarity to hypothetical protein YHR040w -Saccharomyces cerevisiae; uncharacterized protein 1281882 4987404 An14g05460 Aspergillus niger uncharacterized protein XP_059602357.1 1280464 D 5061 CDS An14g05470 4987405 complement(join(1282558..1283318,1283371..1284121)) I 1 NT_166529.1 Function: enterophilins are a new family of proteins with unknown function associated with enterocyte differentiation in C. porcellus.; Title: weak similarity to hypothetical enterophilin-2L - Cavia porcellus; See PMID 11278568; uncharacterized protein 1284121 4987405 An14g05470 Aspergillus niger uncharacterized protein XP_001401170.3 1282558 R 5061 CDS An14g05480 84593025 1285832..1286038 I 1 NT_166529.1 hypothetical protein 1286038 84593025 An14g05480 Aspergillus niger hypothetical protein XP_059602358.1 1285832 D 5061 CDS An14g05490 4987407 1286919..1288175 I 1 NT_166529.1 Title: weak similarity to precursor of licheninase -Bacillus polymyxa; See PMID 1938968; uncharacterized protein 1288175 4987407 An14g05490 Aspergillus niger uncharacterized protein XP_001401172.1 1286919 D 5061 CDS An14g05500 4987408 complement(join(1288908..1289602,1289677..1292764)) I 1 NT_166529.1 Similarity: the BLASTP alignment is very nice, but limited to the C-terminal part of the predicted ORF.; Title: similarity to axin-associating molecule Axam - Rattus norvegicus; See PMID 10944533; uncharacterized protein 1292764 4987408 An14g05500 Aspergillus niger uncharacterized protein XP_001401173.3 1288908 R 5061 CDS An14g05510 4987409 complement(join(1293340..1293390,1293441..1293876,1293965..1294735,1294816..1295159)) I 1 NT_166529.1 Function: YSR3 of S. cerevisiae is involved in regulating ceramide and phosphorylated sphingoid base levels, and modulates stress responses through sphingolipid metabolites.; Remark: YSR3 of S. cerevisiae is also called YKR053c.; Similarity: A. niger EST EMBLEST:BE760128 comprises part of the putative 5'-UTR of the gene and part of exon 1.; Title: strong similarity to dihydrosphingosine-1-phosphate phosphatase Ysr3 -Saccharomyces cerevisiae; See PMID 9041652; See PMID 9195906; See PMID 9353337; See PMID 9419344; uncharacterized protein 1295159 4987409 An14g05510 Aspergillus niger uncharacterized protein XP_059602359.1 1293340 R 5061 CDS An14g05520 84593026 complement(join(1296334..1296499,1296600..1296654,1296831..1296885,1296978..1297073)) I 1 NT_166529.1 Title: questionable ORF; uncharacterized protein 1297073 84593026 An14g05520 Aspergillus niger uncharacterized protein XP_059602360.1 1296334 R 5061 CDS An14g05530 4987411 join(1297919..1298041,1298105..1298308,1298368..1298727) I 1 NT_166529.1 Remark: RHO1 gene encodes a low-molecular-weight GTPase. one of its recently identified functions is the regulation of beta-1,3-glucan synthase, which synthesizes the main component of the fungal cell wall.; Similarity: belongs to the ras transforming proteins.; Title: strong similarity to GTP-binding protein rho1 from patent WO9738129-A1 - Candida sp.; See PMID 9401032; uncharacterized protein 1298727 4987411 An14g05530 Aspergillus niger uncharacterized protein XP_001401176.3 1297919 D 5061 CDS An14g05540 4987412 complement(join(1298787..1298948,1299032..1299056,1299500..1299675,1299976..1300065)) I 1 NT_166529.1 Title: similarity to essential protein #328 from patent WO200286090-A2 - Aspergillus fumigatus; uncharacterized protein 1300065 4987412 An14g05540 Aspergillus niger uncharacterized protein XP_059602361.1 1298787 R 5061 CDS An14g05550 4987413 join(1300852..1300952,1301009..1301055,1301138..1301639,1301688..1302069) I 1 NT_166529.1 Remark: this ORF is a putative alginate lyase by homology.; Similarity: belongs to the NADPH:quinone reductase and related Zn-dependent oxidoreductases.; Similarity: the ORF shows similarity to several oxidoreductases with different specificities.; Title: strong similarity to protein from patent WO0100844-A - Corynebacterium glutamicum; uncharacterized protein 1302069 4987413 An14g05550 Aspergillus niger uncharacterized protein XP_059602362.1 1300852 D 5061 CDS An14g05560 84593027 complement(join(1302371..1302459,1302546..1302601,1302700..1302768,1302879..1302965,1303242..1303317,1303356..1303362)) I 1 NT_166529.1 hypothetical protein 1303362 84593027 An14g05560 Aspergillus niger hypothetical protein XP_059602363.1 1302371 R 5061 CDS An14g05570 84593028 complement(join(1304488..1305171,1305595..1305750,1305899..1305964)) I 1 NT_166529.1 Title: similarity to EST an_3478 - Aspergillus niger; uncharacterized protein 1305964 84593028 An14g05570 Aspergillus niger uncharacterized protein XP_059602364.1 1304488 R 5061 CDS An14g05580 4987416 join(1306468..1306953,1307000..1307290) I 1 NT_166529.1 hypothetical protein 1307290 4987416 An14g05580 Aspergillus niger hypothetical protein XP_001401181.1 1306468 D 5061 CDS An14g05590 4987417 join(1307906..1308716,1308765..1309024) I 1 NT_166529.1 Remark: similarity to human sequence 203 from patent WO0129221-A/203.; Remark: this ORF represemnts a putative DNA repair protein.; Title: similarity to sequence 203 from patent WO0129221-A - Homo sapiens; uncharacterized protein 1309024 4987417 An14g05590 Aspergillus niger uncharacterized protein XP_059602365.1 1307906 D 5061 CDS An14g05600 4987418 complement(join(1309096..1309263,1309310..1310146)) I 1 NT_166529.1 Title: similarity to hypothetical D-alanine-D-alanine ligase B - Aquifex aeolicus; uncharacterized protein 1310146 4987418 An14g05600 Aspergillus niger uncharacterized protein XP_001401183.3 1309096 R 5061 CDS An14g05610 84593029 complement(join(1310564..1310707,1310805..1310990,1311171..1311219,1311711..1311848,1312237..1312436,1312672..1312677)) I 1 NT_166529.1 Title: questionable ORF; uncharacterized protein 1312677 84593029 An14g05610 Aspergillus niger uncharacterized protein XP_059602366.1 1310564 R 5061 CDS An14g05620 84593030 join(1312702..1312959,1313077..1313379,1313516..1313779) I 1 NT_166529.1 Title: similarity to EST an_2924 - Aspergillus niger; uncharacterized protein 1313779 84593030 An14g05620 Aspergillus niger uncharacterized protein XP_059602367.1 1312702 D 5061 CDS An14g05630 4987421 complement(join(1314054..1314612,1314665..1315081,1315168..1315604,1315661..1315798,1315879..1315971)) I 1 NT_166529.1 Catalytic activity: ATP + 4-coumarate + CoA = AMP + pyrophosphate + 4-coumaroyl-CoA.; Pathway: flavonoids, stilbene and lignin biosynthesis.; Remark: the phenylpropanoid enzyme 4-coumarate:coenzyme A ligase (4CL) plays a key role in general phenylpropanoid metabolism. 4CL is related to a larger class of prokaryotic and eukaryotic adenylate-forming enzymes and shares several conserved peptide motifs with these enzymes.; Similarity: belongs to the Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II.; Title: strong similarity to 4-coumarate-CoA ligase 3 4CL3 - Populus balsamifera; See PMID 11405227; uncharacterized protein 1315971 4987421 An14g05630 Aspergillus niger uncharacterized protein XP_059602368.1 1314054 R 5061 CDS An14g05640 84593031 complement(join(1316053..1316191,1316239..1316439,1316487..1316579,1316643..1316833,1316932..1317057,1317178..1317198)) I 1 NT_166529.1 hypothetical protein 1317198 84593031 An14g05640 Aspergillus niger hypothetical protein XP_059602369.1 1316053 R 5061 CDS An14g05650 84593032 join(1317493..1317609,1317730..1317787,1317869..1318025,1318088..1318191,1318653..1318805,1318909..1319045,1319272..1319387,1319464..1319583,1319671..1319737,1319823..1320010,1320140..1320272,1320693..1320811,1320875..1320961,1321055..1321360,1321407..1321552,1321618..1321786,1321984..1322119) I 1 NT_166529.1 hypothetical protein 1322119 84593032 An14g05650 Aspergillus niger hypothetical protein XP_059602370.1 1317493 D 5061 CDS An14g05660 84593033 join(1322404..1322561,1322907..1323009,1323095..1323199) I 1 NT_166529.1 Title: questionable ORF; uncharacterized protein 1323199 84593033 An14g05660 Aspergillus niger uncharacterized protein XP_059602371.1 1322404 D 5061 CDS An14g05670 4987425 join(1323769..1324998,1325068..1325511) I 1 NT_166529.1 Remark: the Japanese pear pathotype of Alternaria alternata produces host-specific AK-toxin and causes black spot of Japanese pear. Transformation of the wild type with AKTR-1- and AKT3-1-targeting vectors produced toxin-deficient (Tox-), nonpathogenic mutants.; Title: similarity to AK-toxin regulating protein AktR-1 - Alternaria alternata; See PMID 10975654; uncharacterized protein 1325511 4987425 An14g05670 Aspergillus niger uncharacterized protein XP_001401190.3 1323769 D 5061 CDS An14g05680 84593034 join(1325867..1326105,1326170..1326284,1326337..1326384,1326427..1326444) I 1 NT_166529.1 hypothetical protein 1326444 84593034 An14g05680 Aspergillus niger hypothetical protein XP_059602372.1 1325867 D 5061 CDS An14g05690 84593035 join(1328983..1329020,1329234..1329284,1329550..1329775,1329895..1330128) I 1 NT_166529.1 Title: questionable ORF; uncharacterized protein 1330128 84593035 An14g05690 Aspergillus niger uncharacterized protein XP_059602373.1 1328983 D 5061 CDS An14g05700 84593036 complement(join(1330248..1330362,1330458..1330535,1330841..1330971,1331072..1331146,1331187..1331258)) I 1 NT_166529.1 Title: strong similarity to hypothetical protein encoded by An01g10130 - Aspergillus niger; uncharacterized protein 1331258 84593036 An14g05700 Aspergillus niger uncharacterized protein XP_059602374.1 1330248 R 5061 CDS An14g05710 84593037 complement(join(1332485..1332549,1332607..1332781,1332860..1333080,1333219..1333312)) I 1 NT_166529.1 Similarity: although the similarity to Rhp16 of S. pombe is weak, some motifs in the predicted ORF suggest that it might be involved in DNA binding and repair.; Title: weak similarity to RAD16 nucleotide excision repair protein homolog rhp16p - Schizosaccharomyces pombe; See PMID 8879272; See PMID 10446227; uncharacterized protein 1333312 84593037 An14g05710 Aspergillus niger uncharacterized protein XP_059602375.1 1332485 R 5061 CDS An14g05720 84593038 join(1333904..1334034,1334125..1334209,1334431..1334554,1334595..1334745,1334792..1334902,1334974..1335026,1335119..1335240) I 1 NT_166529.1 hypothetical protein 1335240 84593038 An14g05720 Aspergillus niger hypothetical protein XP_059602376.1 1333904 D 5061 CDS An14g05730 4987431 complement(join(1335429..1335786,1335837..1336309,1336372..1336439,1336489..1336525,1336578..1336597,1336647..1336658,1336734..1336788)) I 1 NT_166529.1 Function: PTH11 of M. grisea is required for appressorium differentiation in response to inductive surface cues.; Function: as do most fungal plant pathogens, M. grisea differentiates an infection structure specialized for host penetration called the appressorium.; Phenotype: M. grisea cells null mutant for PTH11 are no more pathogenic.; Similarity: the length of the predicted ORF is only one half of the M. grisea PTH11.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529; uncharacterized protein 1336788 4987431 An14g05730 Aspergillus niger uncharacterized protein XP_059602377.1 1335429 R 5061 CDS An14g05740 84593039 complement(join(1337498..1337650,1337723..1337953,1338026..1338104,1338205..1338541,1338627..1338678)) I 1 NT_166529.1 hypothetical protein 1338678 84593039 An14g05740 Aspergillus niger hypothetical protein XP_059602378.1 1337498 R 5061 CDS An14g05750 4987433 join(1338760..1339017,1339080..1339715,1339766..1340137) I 1 NT_166529.1 Catalytic activity: OPR3 of A. thaliana catalyzes the reaction: 8-[(1R,2R)-3-Oxo-2-{(Z)-pent-2-enyl}cyclopentyl]octanoate + NADP+ = (15Z)-12-Oxophyto-10,15-dienoate + NADPH.; Phenotype: A. thaliana ORP3 null mutants are male-sterile due to defects in pollen release caused by a delay in the stomium degeneration program.; Remark: Jasmonic acid (JA) and its precursor 12-oxophytodienoic acid (OPDA) act as plant growth regulators and mediate responses to environmental cues.; Title: strong similarity to 12-oxo-phytodienoate reductase OPR3 - Arabidopsis thaliana; See PMID 10899973; See PMID 10973494; uncharacterized protein 1340137 4987433 An14g05750 Aspergillus niger uncharacterized protein XP_001401198.1 1338760 D 5061 CDS An14g05760 4987434 complement(join(1340292..1340481,1340533..1340585,1340636..1340658,1340715..1340827,1340881..1341241,1341311..1341359)) I 1 NT_166529.1 Catalytic activity: chnA of Acinetobacter catalyzes the reaction: Cyclohexanol + NAD+ <=> Cyclohexanone + NADH.; Similarity: the gene model structure is confirmed by A. niger EST EMBLEST:BE759160, which covers exons 1 to 3.; Title: strong similarity to cyclohexanol dehydrogenase chnA - Acinetobacter sp.; See PMID 10940013; uncharacterized protein 1341359 4987434 An14g05760 Aspergillus niger uncharacterized protein XP_001401199.1 1340292 R 5061 CDS An14g05765 4987435 complement(1342186..1342566) I 1 NT_166529.1 Title: strong similarity to EST an_3120 -Aspergillus niger; uncharacterized protein 1342566 4987435 An14g05765 Aspergillus niger uncharacterized protein XP_003188897.1 1342186 R 5061 CDS An14g05780 4987436 join(1344057..1344871,1344922..1345253,1345303..1345547) I 1 NT_166529.1 Function: the S. cerevisiae ERG4 gene encodes sterol C-24(28) reductase which catalyzes the final step in the biosynthesis of ergosterol.; Remark: ergosterol is the precursor of vitamin D2.; Title: strong similarity to sterol C-24 reductase Erg4 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 7791529; See PMID 8125337; See PMID 9630650; See PMID 10722850; See PMID 1882553; uncharacterized protein 1345547 4987436 An14g05780 Aspergillus niger uncharacterized protein XP_059602379.1 1344057 D 5061 CDS An14g05790 4987437 complement(join(1345923..1346346,1346395..1346630,1346681..1347121,1347160..1347455,1347502..1347891,1347972..1348038,1348177..1348227)) I 1 NT_166529.1 Similarity: the predicted protein shows similarity to several putative and described fungal transcription factors; their common feature is the presence of a typical binuclear cluster zinc-finger, responsible for DNA binding,which is not well conserved in the predicted protein.; Title: weak similarity to transcription activator prnA - Aspergillus nidulans; See PMID 9622360; uncharacterized protein 1348227 4987437 An14g05790 Aspergillus niger uncharacterized protein XP_059602380.1 1345923 R 5061 CDS An14g05800 4987438 1348819..1351344 I 1 NT_166529.1 Function: hydrolysis of alpha-D-1,2-(4-O-methyl)glucuronosyl links in the main chain of hardwood xylans.; Gene-ID: aguA; See PMID 10376490; alpha-glucuronidase aguA-Aspergillus niger 1351344 aguA 4987438 aguA Aspergillus niger alpha-glucuronidase aguA-Aspergillus niger XP_001401203.1 1348819 D 5061 CDS An14g05810 4987439 join(1352109..1352297,1352346..1353398) I 1 NT_166529.1 Complex: GCN5 of S. cerevisiae is a component of the SAGA complex, which posseses histone acetylation function and is important for transcription in vivo.; Function: GCN5 of S. cerevisiae and many other organisms acetylates histones H3 and H4 non-randomly at specific lysines, causing chromatin remodelling during transcriptional activation.; Similarity: in the C-terminal part of the protein there is a bromodomain, which function may be to tether type A histone acetyltransferase to the chromatin during gene activation.; Title: strong similarity to histone acetyltransferase Gcn5 - Saccharomyces cerevisiae; nucleus; See PMID 7862114; See PMID 7957049; See PMID 8601304; See PMID 8805705; See PMID 8943299; uncharacterized protein 1353398 4987439 An14g05810 Aspergillus niger uncharacterized protein XP_001401204.1 1352109 D 5061 CDS An14g05820 4987440 join(1354497..1355114,1355160..1355325,1355375..1355504,1355567..1355675,1355744..1357550,1357639..1357856) I 1 NT_166529.1 Catalytic activity: hydrolysis of terminal,non-reducing beta-d-galactose residues in beta-d-galactosides.; Function: cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.; Remark: beta-galactosidase of A. niger has been already patented under patentnumber WO9010703 and WO9716555-A1.; Similarity: belongs to family 35 of glycosyl hydrolases.; Similarity: the absence of nice BLASTN alignments,demonstrates that the predicted ORF is just an homologue of the already described beta-galactosidase of A. niger.; Title: strong similarity to beta-galactosidase lacA - Aspergillus niger; extracellular/secretion proteins; See PMID 1368193; uncharacterized protein 1357856 4987440 An14g05820 Aspergillus niger uncharacterized protein XP_001401205.1 1354497 D 5061 CDS An14g05830 4987441 complement(1358026..1359819) I 1 NT_166529.1 Function: co-expression of het-e and het-c lead to cell death.; Function: het-e1 of P. anserina is responsible for vegetative incompatibility.; Remark: het-e1 of P. anserina shows also two sequence motifs, a GTP-binding domain and a repeated region that shares similarity with that of the beta-transducin.; Remark: the reactivity of the HET-E protein depends on two functional elements, a GTP-binding domain and several WD40 repeats.; Similarity: the similarity to het-e1 involves only the N-terminal half of the predicted protein.; Title: similarity to beta transducin-like protein het-e1 - Podospora anserina; See PMID 7557402; See PMID 9435787; See PMID 10875280; See PMID 10974123; uncharacterized protein 1359819 4987441 An14g05830 Aspergillus niger uncharacterized protein XP_059602381.1 1358026 R 5061 CDS An14g05840 4987442 complement(join(1360819..1361180,1361243..1361699,1361752..1361864,1361924..1362050,1362101..1362298)) I 1 NT_166529.1 Catalytic activity: A. flavus omtB converts demethylsterigmatocystin (DMST) to sterigmatocystin (ST) and dihydrodemethylsterigmatocystin (DHDMST) to dihydrosterigmatocystin (DHST).; Function: A. flavus omtB is a demethylsterigmatocystin 6-O-methyltransferase involved in aflatoxin biosynthesis.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Title: strong similarity to O-methyltransferase omtB - Aspergillus flavus; See PMID 10806361; uncharacterized protein 1362298 4987442 An14g05840 Aspergillus niger uncharacterized protein XP_059602382.1 1360819 R 5061 CDS An14g05850 4987443 join(1363262..1363856,1363910..1364027,1364075..1364235,1364289..1364322,1364379..1364784) I 1 NT_166529.1 Function: PTH11 of M. grisea is required for appressorium differentiation in response to inductive surface cues.; Function: as do most fungal plant pathogens, M. grisea differentiates an infection structure specialized for host penetration called the appressorium.; Phenotype: M. grisea cells null mutant for PTH11 are no more pathogenic.; Similarity: the similarity to PTH11 of M. grisea is limited to the N-terminal half of the predicted ORF.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529; uncharacterized protein 1364784 4987443 An14g05850 Aspergillus niger uncharacterized protein XP_059602383.1 1363262 D 5061 CDS An14g05860 84593040 1365162..1366817 I 1 NT_166529.1 hypothetical protein 1366817 84593040 An14g05860 Aspergillus niger hypothetical protein XP_059602384.1 1365162 D 5061 CDS An14g05870 4987445 join(1367551..1367740,1367795..1367862,1367916..1368295,1368357..1368421,1368480..1368718) I 1 NT_166529.1 Function: PTH11 of M. grisea is required for appressorium differentiation in response to inductive surface cues.; Function: as do most fungal plant pathogens, M. grisea differentiates an infection structure specialized for host penetration called the appressorium.; Phenotype: M. grisea cells null mutant for PTH11 are no more pathogenic.; Similarity: the length of the predicted ORF is only one half of the M. grisea PTH11.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529; uncharacterized protein 1368718 4987445 An14g05870 Aspergillus niger uncharacterized protein XP_001401210.1 1367551 D 5061 CDS An14g05880 4987446 join(1369848..1370138,1370202..1370723,1370807..1370860,1370970..1371296) I 1 NT_166529.1 Similarity: the central part of the predicted ORF shows only weak similarity to N. crassa B9I2. 20.; Title: strong similarity to hypothetical conserved protein B9I2.20 - Neurospora crassa; uncharacterized protein 1371296 4987446 An14g05880 Aspergillus niger uncharacterized protein XP_059602385.1 1369848 D 5061 CDS An14g05890 4987447 join(1371585..1372144,1372201..1373266) I 1 NT_166529.1 Remark: CLA compounds(cis,trans)-9,11-linoleic acid and (trans, cis)-10,12-linoleic acid are recognised nutritional supplements and effective inhibitors of epidermal carcinogenesis and forestomach neoplasia; furthermore CLA has also been shown to prevent adverse effects caused by immune stimulation in chicks, mice and rats, and has been shown to decrease the ratio of low density lipoprotein cholesterol to high density lipoprotein cholesterol.; Remark: the linoleate isomerase is used in a method for producing conjugated linoleic/linolenic acid (CLA) from oils such as sunflower oil, safflower oil, corn oil,linseed oil, etc.; Similarity: the N-terminal part of the prediction ORF shows also weak similarity to some oxidoreductases.; Similarity: the patented protein, as well as the predicted ORF, show strong similarity to the 67 kDa myosin-crossreactive streptococcal antigen of Streptococcus pyogenes, a protein with unknown function, but involved in the pathogenesis of streptococcal infections.; Title: strong similarity to linoleate isomerase protein sequence PCLA591 from patent WO9932604-A1 -Lactobacillus reuteri; See PMID 8188369; uncharacterized protein 1373266 4987447 An14g05890 Aspergillus niger uncharacterized protein XP_001401212.1 1371585 D 5061 CDS An14g05900 4987448 complement(join(1374138..1374185,1374264..1376042)) I 1 NT_166529.1 Similarity: other BLASTP hits are explained by the relatively high content of low-complexity regions.; Title: strong similarity to hypothetical protein B14D6.80 - Neurospora crassa; uncharacterized protein 1376042 4987448 An14g05900 Aspergillus niger uncharacterized protein XP_059602386.1 1374138 R 5061 CDS An14g05910 4987449 complement(join(1376261..1376868,1376959..1377383,1377405..1377772)) I 1 NT_166529.1 Function: ALG2 of S. cerevisiae is involved in N-glycosylation, converting man[2]glcnac-pp-dolichol to man[3]glcnac-pp-dolichol.; Title: strong similarity to mannosyltransferase Alg2 - Saccharomyces cerevisiae; See PMID 2660743; See PMID 8400550; uncharacterized protein 1377772 4987449 An14g05910 Aspergillus niger uncharacterized protein XP_059602387.1 1376261 R 5061 CDS An14g05920 4987450 complement(join(1378654..1379193,1379254..1383306,1383363..1383538,1383595..1383918,1384063..1384222)) I 1 NT_166529.1 Function: kinesins are microtubule-dependent motor proteins, involved in organelle transport, in mitosis and meiosis, and in the transport of synaptic vesicles along axons of animal neurons.; Similarity: the closest homologues, comprising XCENP-E of X. laevis, are involved in driving congression of chromosomes to the metaphase plate.; Similarity: the main feature of the predicted ORF is to contain, in the N-terminal half, several kinesin-like domains, explaining the strong similarity to several different kinesin-like proteins.; Similarity: the predicted ORF has just half of the length of XCENP-E of X. laevis; the best homologue, having also a corresponding length, is a N. crassa hypothetical protein.; Title: strong similarity to kinesin-related protein XCENP-E - Xenopus laevis; See PMID 9363944; uncharacterized protein 1384222 4987450 An14g05920 Aspergillus niger uncharacterized protein XP_059602388.1 1378654 R 5061 CDS An14g05930 84593041 complement(join(1384930..1385065,1385545..1385643,1385730..1385988,1386434..1386473)) I 1 NT_166529.1 Similarity: the similarity to NAB2 of M. musculus is weak, and the gene structure of the predicted ORF is questionable.; Title: weak similarity to NGFI-A binding protein 2 NAB2 - Mus musculus; See PMID 7624335; See PMID 8668170; uncharacterized protein 1386473 84593041 An14g05930 Aspergillus niger uncharacterized protein XP_059602389.1 1384930 R 5061 CDS An14g05940 84593042 complement(join(1387200..1387307,1387378..1387482,1387576..1387635,1387722..1388033,1388407..1388472,1388565..1388666,1388741..1388767)) I 1 NT_166529.1 Similarity: very weak similarity to a fragment of protein SEQ ID NO:917 of patent n. WO200042171-A1 of Eucalyptus grandis.; Title: questionable ORF; uncharacterized protein 1388767 84593042 An14g05940 Aspergillus niger uncharacterized protein XP_059602390.1 1387200 R 5061 CDS An14g05950 84593043 complement(join(1389751..1390599,1390647..1391003,1391237..1391260)) I 1 NT_166529.1 Similarity: a short stretch of amino acids of the predicted ORF shows some weak similarity to an A. thaliana hypothetical protein.; hypothetical protein 1391260 84593043 An14g05950 Aspergillus niger hypothetical protein XP_059602391.1 1389751 R 5061 CDS An14g05960 4987454 complement(join(1392040..1392124,1392184..1392334,1392388..1392480,1392533..1392750,1392799..1393020,1393070..1393153,1393217..1393307,1393380..1393476,1393527..1393661)) I 1 NT_166529.1 Catalytic activity: H2O + agmatine <=> urea + putrescine.; Complex: agmatinase of E. coli is a homodimer of the speB gene product.; Function: agmatinase of E. coli is part of the second putrescine biosynthetic pathway; it also represents the only pathway for urea biosynthesis in E. coli as no urease is present.; Similarity: the predicted ORF shows much stronger similarity to putative agmatinases of N. crassa and S. pombe.; Title: strong similarity to agmatinase speB -Escherichia coli; See PMID 2153656; See PMID 1310091; uncharacterized protein 1393661 4987454 An14g05960 Aspergillus niger uncharacterized protein XP_001401219.1 1392040 R 5061 CDS An14g05970 4987455 complement(join(1394612..1395540,1395609..1396194)) I 1 NT_166529.1 Title: strong similarity to hypothetical protein SPAC11D3.06 - Schizosaccharomyces pombe; uncharacterized protein 1396194 4987455 An14g05970 Aspergillus niger uncharacterized protein XP_001401220.1 1394612 R 5061 CDS An14g05980 4987456 join(1397459..1398011,1398055..1398156,1398213..1398928) I 1 NT_166529.1 Function: TPO3 of S. cerevisiae is a vacuolar polyamine transporter, that controlls the cytoplasmic spermine content.; Phenotype: S. cerevisiae cells in which TPO3 was disrupted showed an increased sensitivity to polyamine toxicity and a decrease in polyamine uptake activity and polyamine content in vacuoles.; Phenotype: S. cerevisiae cells overexpressing TPO3 were resistant to polyamine toxicity and showed an increase in polyamine uptake activity and polyamine content in vacuoles.; Remark: TPO3 of S. cerevisiae is also called YPR156c or P9584. 7.; Similarity: the predicted ORF is 125 amino acids longer at the N-terminus than TPO3 of S. cerevisiae.; Title: strong similarity to polyamine transport protein Tpo3 - Saccharomyces cerevisiae; uncharacterized protein 1398928 4987456 An14g05980 Aspergillus niger uncharacterized protein XP_059602392.1 1397459 D 5061 CDS An14g05990 4987457 complement(join(1399876..1402055,1402143..1402213,1402299..1402336,1402482..1402625)) I 1 NT_166529.1 Title: weak similarity to spindle pole body-associated protein sad1p - Schizosaccharomyces pombe; uncharacterized protein 1402625 4987457 An14g05990 Aspergillus niger uncharacterized protein XP_001401222.3 1399876 R 5061 CDS An14g06000 4987458 complement(join(1403233..1403508,1403560..1404350,1404416..1404616,1404671..1405271,1405354..1405440)) I 1 NT_166529.1 Function: MDV1 of S. cerevisiae is involved in the mitochondrial membrane fission event by regulating the assembly of Dnm1p, a dynamin-related GTPase, into punctate structures at the outer mitochondrial membrane.; Phenotype: the mitochondrial fission is blocked in S. cerevisiae MDV null mutants and mitochondrial membranes form nets.; Remark: is also called YJL112w, NET2, FIS2 or GAG3.; Title: strong similarity to mitochondrial fission protein Mdv1 - Saccharomyces cerevisiae; See PMID 11038182; See PMID 11038183; uncharacterized protein 1405440 4987458 An14g06000 Aspergillus niger uncharacterized protein XP_059602393.1 1403233 R 5061 CDS An14g06010 4987459 join(1406227..1406297,1406525..1407176,1407233..1407310) I 1 NT_166529.1 Catalytic activity: chorismate mutases convert chorismate <=> prephenate.; Function: aroC of A. nidulans is an allosterically regulated chorismate mutase acting at the first branch point of aromatic amino acid biosynthesis to generate prephenate.; Induction: tryptophan acts as heterotropic activator of aroC from A. nidulans.; Repression: tyrosine act as negative acting,heterotropic feedback-inhibitor of aroC from A. nidulans.; Title: strong similarity to chorismate mutase aroC -Aspergillus nidulans; cytoplasm; See PMID 10428795; uncharacterized protein 1407310 4987459 An14g06010 Aspergillus niger uncharacterized protein XP_001401224.3 1406227 D 5061 CDS An14g06020 4987460 complement(join(1407511..1408065,1408124..1408360,1408453..1408536)) I 1 NT_166529.1 Similarity: the ORF shows similarity to putative cdk inhibotor p21 binding protein TOK-1 of H. sapiens.; Title: strong similarity to hypothetical cdk inhibitor p21 binding protein SPCC613.08 -Schizosaccharomyces pombe; uncharacterized protein 1408536 4987460 An14g06020 Aspergillus niger uncharacterized protein XP_001401225.1 1407511 R 5061 CDS An14g06030 84593044 join(1409190..1409226,1409288..1409388) I 1 NT_166529.1 Remark: the predicted ORF is only 45 amino acids long.; hypothetical protein 1409388 84593044 An14g06030 Aspergillus niger hypothetical protein XP_059602394.1 1409190 D 5061 CDS An14g06040 4987462 complement(1410910..1411866) I 1 NT_166529.1 Similarity: the predcited ORF is 96 amino acids longer at the N-terminus than the hypothetical protein SPBC17D11. 03c of S. pombe.; Title: weak similarity to hypothetical protein SPBC17D11.03c - Schizosaccharomyces pombe; uncharacterized protein 1411866 4987462 An14g06040 Aspergillus niger uncharacterized protein XP_001401227.3 1410910 R 5061 CDS An14g06050 4987463 join(1412375..1412713,1412785..1412886) I 1 NT_166529.1 Title: weak similarity to hypothetical protein B10H18.060 - Neurospora crassa; uncharacterized protein 1412886 4987463 An14g06050 Aspergillus niger uncharacterized protein XP_059602395.1 1412375 D 5061 CDS An14g06060 4987464 complement(1413324..1414490) I 1 NT_166529.1 Function: TTP1 of S. cerevisiae is involved in the transfer of mannose residues to the mannans of glycoproteins during maturation in the Golgi.; Function: the correct mannosylation of proteins by TTP1 of S. cerevisiae is essential for growth and morphogenesis.; Golgi; Phenotype: the N-linked sugar residues in the S. cerevisiae TTP1 null mutant lack the main alpha-1,2-linked branches of the mannan.; Remark: TTP1 of S. cerevisiae is also called mnn2 or YBR015C.; Title: strong similarity to alpha-1,2-mannosyltransferase Ttp1 - Saccharomyces cerevisiae; See PMID 9413431; See PMID 9756928; See PMID 9878809; uncharacterized protein 1414490 4987464 An14g06060 Aspergillus niger uncharacterized protein XP_001401229.3 1413324 R 5061 CDS An14g06070 4987465 join(1416586..1416669,1416712..1418955,1419271..1419404,1419511..1419519,1419708..1419769,1419884..1420062,1420272..1420312,1420454..1420490,1420640..1420687,1420741..1420775,1420837..1420930) I 1 NT_166529.1 Title: similarity to hypothetical protein CAD11325.1 - Neurospora crassa; uncharacterized protein 1420930 4987465 An14g06070 Aspergillus niger uncharacterized protein XP_001401230.3 1416586 D 5061 CDS An14g06080 84593045 join(1421438..1421552,1421633..1421968,1422066..1422159,1422245..1422380,1422445..1422496,1422608..1422723) I 1 NT_166529.1 hypothetical protein 1422723 84593045 An14g06080 Aspergillus niger hypothetical protein XP_059606442.1 1421438 D 5061 CDS An14g06090 4987467 1425131..1426306 I 1 NT_166529.1 hypothetical protein 1426306 4987467 An14g06090 Aspergillus niger hypothetical protein XP_059606443.1 1425131 D 5061 CDS An14g06100 4987468 complement(join(1427396..1427666,1427886..1428423,1428524..1428620)) I 1 NT_166529.1 Title: strong similarity to hypothetical protein BAC71605.1 - Streptomyces avermitilis; uncharacterized protein 1428620 4987468 An14g06100 Aspergillus niger uncharacterized protein XP_059606444.1 1427396 R 5061 CDS An14g06110 4987469 join(1428851..1429763,1429814..1430240,1430291..1430579,1430639..1431115) I 1 NT_166529.1 Title: weak similarity to gene expression regulator At221 from patent WO200257456-A2 - Unclassified organism; uncharacterized protein 1431115 4987469 An14g06110 Aspergillus niger uncharacterized protein XP_001401234.3 1428851 D 5061 CDS An14g06120 84593046 complement(join(1431453..1431588,1431692..1431803,1431916..1432004,1432234..1432340,1432384..1432482)) I 1 NT_166529.1 hypothetical protein 1432482 84593046 An14g06120 Aspergillus niger hypothetical protein XP_059606445.1 1431453 R 5061 CDS An14g06130 84593047 complement(join(1433981..1434993,1435077..1435689)) I 1 NT_166529.1 Remark: the predicted protein sequence of the ORF contains a poly-asparagine stretch, that shows unspecific homology to several asparagine-rich proteins.; Title: strong similarity to hypothetical protein encoded by An06g01430 - Aspergillus niger; uncharacterized protein 1435689 84593047 An14g06130 Aspergillus niger uncharacterized protein XP_059606446.1 1433981 R 5061 CDS An14g06140 4987472 join(1436424..1436475,1436606..1437114,1437282..1437357,1437418..1437853,1437919..1438078,1438150..1438249,1438318..1438574) I 1 NT_166529.1 Title: strong similarity to hypothetical protein encoded by An14g07070 - Aspergillus niger; uncharacterized protein 1438574 4987472 An14g06140 Aspergillus niger uncharacterized protein XP_059606447.1 1436424 D 5061 CDS An14g06150 4987473 complement(join(1438731..1438771,1438811..1438861,1439046..1443915)) I 1 NT_166529.1 Function: the insecticidal toxin of P. luminescens has activity against Lepidopteran insects such as Cabbage Looper (Trichoplusia ni), European Corn Borer (Ostrinia nubialis) and Fall Armyworm (Spodoptera frugiperda) and also against Coleopteran insects (e. g., Colorado Potato Beetle, Leptinotarsa decimlineata).; Similarity: the ORF shows similarity to the probable nematicidal protein 2 xnp2 of X. bovienii, which is believed to mediate cell lysis in nematodes.; Title: strong similarity to insecticidal toxin from patent WO9942589-A2 - Photorhabdus luminescens; See PMID 11375158; uncharacterized protein 1443915 4987473 An14g06150 Aspergillus niger uncharacterized protein XP_001401238.3 1438731 R 5061 CDS An14g06160 4987474 1445804..1446799 I 1 NT_166529.1 Title: strong similarity to hypothetical protein encoded by An08g09580 - Aspergillus niger; uncharacterized protein 1446799 4987474 An14g06160 Aspergillus niger uncharacterized protein XP_001401239.1 1445804 D 5061 CDS An14g06170 84593048 join(1447723..1448071,1448173..1448546,1448913..1449006,1449251..1449385,1449499..1449839) I 1 NT_166529.1 Remark: alignment of A. niger ESTs with similarity to the predicted protein indicates alternative splicing.; Similarity: additionally, the ORF shows similarity to similarity to EST an_3586 (EMBLEST:BE759248) of Aspergillus niger.; Title: similarity to hypothetical protein AAK62875.1 - Microscilla sp.; uncharacterized protein 1449839 84593048 An14g06170 Aspergillus niger uncharacterized protein XP_059606448.1 1447723 D 5061 CDS An14g06180 4987476 join(1450824..1451112,1451183..1452870) I 1 NT_166529.1 Function: KIF1A of H. sapiens is a motor protein for the anterograde axonal transport of synaptic vesicles by using the hydrolysis of ATP to generate force and movement along their cellular tracks, the microtubules.; Remark: KIF1A of H. sapiens is also called ATSV.; Similarity: the ORF show similarity to the N-terminal region of KIF1A from H. sapiens, which does not include the FHA domain, that is a putative nuclear signalling domain and the 'pleckstrin homology' (PH) domain, which is a domain that occurs in a wide range of proteins involved in intracellular signaling, but the region inculdes the motor domain.; Title: strong similarity to kinesin motor protein KIF1A - Homo sapiens; See PMID 10660047; See PMID 11163129; See PMID 7539720; uncharacterized protein 1452870 4987476 An14g06180 Aspergillus niger uncharacterized protein XP_001401241.1 1450824 D 5061 CDS An14g06190 4987477 join(1453399..1455093,1455214..1455275,1455326..1455356,1455394..1455729) I 1 NT_166529.1 Remark: alternative splicing for murine proteins described.; Similarity: shows only partial similarity to protein of S. cerevisiae.; Similarity: shows stronger similarity to undescribed translation initiation factors of several species.; Title: similarity to translation initiation factor eIF2B 71 kDa delta subunit Gcd2 - Saccharomyces cerevisiae; cytoplasm; See PMID 9472020; See PMID 2038326; uncharacterized protein 1455729 4987477 An14g06190 Aspergillus niger uncharacterized protein XP_059606449.1 1453399 D 5061 CDS An14g06200 4987478 complement(join(1456327..1456407,1456459..1456581,1456639..1457932,1458176..1458507)) I 1 NT_166529.1 Complex: DNA polymerase alpha in a complex with DNA primase is a replicative polymerase.; Function: POL12 is involved in stimulation of formation of Holliday junctions.; Function: POL12 is required for initiation of DNA replication at a stage before the hydroxyurea step.; Title: strong similarity to DNA-directed DNA polymerase alpha 70 KD subunit Pol12 - Saccharomyces cerevisiae; nucleus; See PMID 9230305; uncharacterized protein 1458507 4987478 An14g06200 Aspergillus niger uncharacterized protein XP_059606450.1 1456327 R 5061 CDS An14g06210 4987479 join(1458912..1459731,1459779..1460101) I 1 NT_166529.1 Function: PDR16 and PDR17 control levels of various lipids in various compartments of the cell and thereby provide a mechanism for multidrug resistance unrecognized so far.; Function: deletion of PDR16 resulted in hypersensitivity of yeast to azole inhibitors of ergosterol biosynthesis.; Title: strong similarity to protein involved in lipid biosynthesis and multidrug resistance Pdr16 -Saccharomyces cerevisiae; See PMID 9890948; uncharacterized protein 1460101 4987479 An14g06210 Aspergillus niger uncharacterized protein XP_001401244.1 1458912 D 5061 CDS An14g06220 4987480 join(1461382..1461435,1461733..1461860,1461934..1462097,1462151..1462507,1462566..1462675,1462724..1462886,1462937..1463037) I 1 NT_166529.1 Function: patented protein SNF4 is involved in carbon catabolite repression in plants and seeds.; Similarity: shows also strong similarity to regulatory protein SNF4 of S. cerevisiae.; Title: strong similarity to sucrose non-fermenting 4 protein SNF4 from patent WO200036116-A2 - Glycine max; nucleus; uncharacterized protein 1463037 4987480 An14g06220 Aspergillus niger uncharacterized protein XP_059606451.1 1461382 D 5061 CDS An14g06230 4987481 join(1463619..1464567,1464629..1465731,1466418..1466627,1466681..1466698) I 1 NT_166529.1 Similarity: hypothetical protein of S. aureus is similar to streptococcal hemagglutinin protein.; Similarity: shows only partial similarity to proteins containing high content of repetitive sequences.; Title: weak similarity to hypothetical protein CAE76144.1 - Neurospora crassa; uncharacterized protein 1466698 4987481 An14g06230 Aspergillus niger uncharacterized protein XP_059606452.1 1463619 D 5061 CDS An14g06240 84593049 complement(join(1466920..1467116,1467160..1467498,1467704..1467788,1467865..1467963,1468040..1468234,1468329..1468409,1468540..1468629)) I 1 NT_166529.1 Function: PEK phosphorylates eukaryotic translation initiation factor-2 alpha.; Function: the present sequence of R. spec. encodes a pancreatic eukaryotic translation initiation factor-2 alpha kinase (PEK).; Similarity: shows only partial similarity to hypothetical proteins and to PEK.; Title: weak similarity to eukaryotic translation initiation factor-2 alpha kinase PEK from patent WO9938994-A1 - Rattus sp.; uncharacterized protein 1468629 84593049 An14g06240 Aspergillus niger uncharacterized protein XP_059606453.1 1466920 R 5061 CDS An14g06250 4987483 1468756..1469781 I 1 NT_166529.1 Similarity: similarity to S. pombe transcription factor is restricted to middle part and carboxyterminus.; Title: weak similarity to transcription factor atf21p - Schizosaccharomyces pombe; nucleus; See PMID 10102365; See PMID 8824587; uncharacterized protein 1469781 4987483 An14g06250 Aspergillus niger uncharacterized protein XP_001401248.1 1468756 D 5061 CDS An14g06260 4987484 complement(1470619..1471803) I 1 NT_166529.1 Function: QUTD is a quinate permease.; Function: belongs to the superfamily of maltose transport protein MAL61.; Similarity: similarity to quinate transport proteins resticted to middle part and carboxyterminus.; Title: strong similarity to quinate transport protein qutD - Aspergillus nidulans; See PMID 2976880; uncharacterized protein 1471803 4987484 An14g06260 Aspergillus niger uncharacterized protein XP_059606454.1 1470619 R 5061 CDS An14g06270 4987485 complement(join(1472588..1474621,1474684..1474689)) I 1 NT_166529.1 Similarity: shows only partial similarity to proteins containing Zn(2)-Cys(6) zinc-finger domains.; Title: weak similarity to negative acting factor naf - Nectria haematococca; nucleus; See PMID 9139694; uncharacterized protein 1474689 4987485 An14g06270 Aspergillus niger uncharacterized protein XP_059606455.1 1472588 R 5061 CDS An14g06280 4987486 complement(join(1474904..1475185,1475238..1475777,1475825..1475982,1476029..1476068,1476115..1476278,1476335..1476683)) I 1 NT_166529.1 Function: IREG1 is a basolateral membrane protein involved in iron transport from the intestine to the circulation; highly expressed in duodenal mucosa and placenta.; Title: strong similarity to iron-regulated transporter IREG1 - Mus musculus; plasma membrane; See PMID 10882071; uncharacterized protein 1476683 4987486 An14g06280 Aspergillus niger uncharacterized protein XP_001401251.1 1474904 R 5061 CDS An14g06290 4987487 complement(join(1477558..1478775,1478846..1479004,1479058..1479108)) I 1 NT_166529.1 Function: Human 3-hydroxyisobutyryl-coenzyme A hydrolase (HIB- CoA hydrolase) can be used for treating,preventing and diagnosing disorders associated with cellular accumulation of methacrylyl-CoA.; Function: such disorders include metabolic disorders such as methacrylic aciduria, congenital defects such as cardiac abnormalities, neurological abnormalities,musculoskeletal and connective tissue abnormalities and other instances of cellular damage.; Similarity: shows also strong similarity to probable enoyl-CoA-hydratase of S. pombe and N. crassa.; Title: strong similarity to 3-hydroxyisobutyryl-coenzyme A hydrolase from patent WO9851782-A2 - Homo sapiens; mitochondrial 37S ribosomal protein mS47 1479108 4987487 An14g06290 Aspergillus niger mitochondrial 37S ribosomal protein mS47 XP_001401252.3 1477558 R 5061 CDS An14g06300 4987488 complement(join(1479713..1480498,1480586..1480669)) I 1 NT_166529.1 Title: strong similarity to mitochondrial ribosomal protein of the large subunit Yml6 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9151978; See PMID 9445368; mitochondrial 54S ribosomal protein uL4m 1480669 4987488 An14g06300 Aspergillus niger mitochondrial 54S ribosomal protein uL4m XP_001401253.1 1479713 R 5061 CDS An14g06310 4987489 join(1480920..1481457,1481517..1482241) I 1 NT_166529.1 Title: strong similarity to mitochondrial ribosomal protein of the large subunit Yml35 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9151978; See PMID 9445368; mitochondrial 54S ribosomal protein mL38 1482241 4987489 An14g06310 Aspergillus niger mitochondrial 54S ribosomal protein mL38 XP_001401254.1 1480920 D 5061 CDS An14g06320 4987490 complement(join(1482412..1482614,1482694..1483030)) I 1 NT_166529.1 EC:3.4.99.36; Function: IMP1 catalyzes the removal of signal peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space.; Function: IMP1 cleaves after Mas1p and Mas2p in the matrix have cleaved the transit peptide to expose the signal for re-export.; Function: IMP1 is required for respiratory function.; Function: IMP1 removes inner membrane space (IMS) targeting peptides for Cyb2p and Cox2p but not for Cyt1p.; Title: strong similarity to mitochondrial protease Imp1 - Saccharomyces cerevisiae; localisation:mitochondrion; uncharacterized protein 1483030 4987490 An14g06320 Aspergillus niger uncharacterized protein XP_059606456.1 1482412 R 5061 CDS An14g06330 4987491 complement(join(1483501..1483653,1483704..1483781,1483811..1484310,1484384..1484582)) I 1 NT_166529.1 Function: the patented sequence may be useful in the control of gene expression as a promoter, coding sequence,3'UTR or termination sequence, for controlling the behaviour of a gene within the chromosome, as a tool for use in genetic mapping, including a use in hybridisation assays, for recognition or isolation of similar DNA fragments, or for the identification of a particular organism.; Function: the protein it encodes may have a use in protein identification and in the elucidation of signal transduction and metabolic pathways.; Similarity: shows stronger similarity to hypothetical proteins of A. thaliana and O. sativa.; Title: similarity to protein fragment SEQ ID NO:498 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 1484582 4987491 An14g06330 Aspergillus niger uncharacterized protein XP_059606457.1 1483501 R 5061 CDS An14g06340 4987492 complement(join(1484865..1484948,1485000..1485026,1485074..1485208,1485257..1485348,1485401..1485611,1485661..1485694,1485739..1485810,1485878..1486022,1486074..1486173)) I 1 NT_166529.1 Function: RSP29, a protein secreted by rat round spermatids, stimulates the secretory function of Sertoli cells in the testis.; Function: the enzyme of R. norvegicus plays a regulatory role in spermatogenesis.; Similarity: shows also similarity to fungal hydroxyacylglutathione hydrolases that function in aminoacid degradation. .; Title: strong similarity to hydroxyacylglutathione hydrolase RSP29 - Rattus norvegicus; uncharacterized protein 1486173 4987492 An14g06340 Aspergillus niger uncharacterized protein XP_059606458.1 1484865 R 5061 CDS An14g06350 4987493 complement(join(1486517..1486991,1487049..1487528,1487601..1487740,1487804..1487923)) I 1 NT_166529.1 Function: LAS1 might play a role in regulating bud formation and morphogenesis via the expression of components that function directly in these processes.; Similarity: shows stronger similarity to undescribed proteins of N. crassa and S. pombe.; Title: similarity to nuclear protein Las1 -Saccharomyces cerevisiae; nucleus; See PMID 8582632; uncharacterized protein 1487923 4987493 An14g06350 Aspergillus niger uncharacterized protein XP_001401258.1 1486517 R 5061 CDS An14g06360 4987494 complement(1488359..1489573) I 1 NT_166529.1 Similarity: shows also similarity to cDNA clone 0386 3' an_0386 of A. niger.; Title: similarity to hypothetical protein 93G11.280 - Neurospora crassa; uncharacterized protein 1489573 4987494 An14g06360 Aspergillus niger uncharacterized protein XP_003188898.1 1488359 R 5061 CDS An14g06370 84593050 join(1489775..1489902,1490111..1490206,1490379..1490431,1490855..1490914,1491023..1491078) I 1 NT_166529.1 hypothetical protein 1491078 84593050 An14g06370 Aspergillus niger hypothetical protein XP_059606459.1 1489775 D 5061 CDS An14g06380 84593051 join(1491511..1491570,1491614..1491754,1491926..1492171,1492277..1492497,1492610..1492732,1492851..1493175) I 1 NT_166529.1 Similarity: shows only partial similarity to hypothetical proteins with high content of repetitive sequences.; Title: weak similarity to hypothetical protein MT0291.4 - Mycobacterium tuberculosis; uncharacterized protein 1493175 84593051 An14g06380 Aspergillus niger uncharacterized protein XP_059606460.1 1491511 D 5061 CDS An14g06390 84593052 join(1493344..1493447,1493500..1493667,1493719..1493851) I 1 NT_166529.1 Function: protein inta6 described in Herlevsen M. C. Thesis (2001).; Similarity: shows only partial similarity to integrin alpha 6 subchain inta6 of R. norvegicus.; Title: weak similarity to integrin alpha 6 subchain inta6 - Rattus norvegicus; uncharacterized protein 1493851 84593052 An14g06390 Aspergillus niger uncharacterized protein XP_059606461.1 1493344 D 5061 CDS An14g06400 84593053 join(1494203..1494252,1494483..1494576,1494655..1494758,1494846..1494920,1495035..1495079,1495196..1495403) I 1 NT_166529.1 hypothetical protein 1495403 84593053 An14g06400 Aspergillus niger hypothetical protein XP_059606462.1 1494203 D 5061 CDS An14g06410 84593054 complement(join(1495933..1496064,1496386..1496419,1496481..1496688,1496744..1497096,1497355..1497453,1497544..1497644,1497740..1497824,1498272..1498333,1498440..1498537,1498865..1498935,1499099..1499262)) I 1 NT_166529.1 hypothetical protein 1499262 84593054 An14g06410 Aspergillus niger hypothetical protein XP_059606463.1 1495933 R 5061 CDS An14g06420 84593055 join(1499534..1499691,1500436..1500705,1500794..1500890) I 1 NT_166529.1 hypothetical protein 1500890 84593055 An14g06420 Aspergillus niger hypothetical protein XP_059606464.1 1499534 D 5061 CDS An14g06430 4987501 join(1501714..1501755,1501822..1501872,1501940..1502906,1502962..1503238,1503298..1503481) I 1 NT_166529.1 Function: S. cerevisiae ferrireductase system might be a multicomponent electron-transport chain.; Function: protein of S. cerevisiae is involved in ferric reduction.; Title: strong similarity to protein associated with ferric reductase activity Utr1 - Saccharomyces cerevisiae; See PMID 8662826; uncharacterized protein 1503481 4987501 An14g06430 Aspergillus niger uncharacterized protein XP_059606465.1 1501714 D 5061 CDS An14g06440 4987502 join(1504751..1505037,1505105..1505597) I 1 NT_166529.1 Remark: function of proteins is not specified in the abstract of the patent.; Similarity: shows also strong similarity to homolog to yeast BET3 involved in targeting and fusion of ER to Golgi transport vesicles of S. pombe.; Title: strong similarity to protein of sequence 1 from patent WO0075305 - Candida albicans; endoplasmatic reticulum; uncharacterized protein 1505597 4987502 An14g06440 Aspergillus niger uncharacterized protein XP_001401267.1 1504751 D 5061 CDS An14g06450 4987503 complement(1506062..1507546) I 1 NT_166529.1 Title: similarity to hypothetical human microfibrillar-associated protein 1 homolog SPAC1782.03 -Schizosaccharomyces pombe; uncharacterized protein 1507546 4987503 An14g06450 Aspergillus niger uncharacterized protein XP_001401268.1 1506062 R 5061 CDS An14g06460 4987504 join(1507978..1508223,1508315..1508369,1508453..1508520) I 1 NT_166529.1 Title: similarity to hypothetical protein CAD70946.1 - Neurospora crassa; uncharacterized protein 1508520 4987504 An14g06460 Aspergillus niger uncharacterized protein XP_001401269.1 1507978 D 5061 CDS An14g06470 4987505 complement(join(1509053..1510398,1510450..1512437,1512506..1512659,1512732..1512771)) I 1 NT_166529.1 Similarity: the ORF overlaps with A. niger EST (EMBLEST:BE759883) an_2819.; Similarity: the predicted ORF probably contains intron sequences, as the ORF is around 400 amino acids longer than the putatibe S. pombe protein SPCC4F11. 01.; Title: similarity to hypothetical transcription regulator SPCC4F11.01 - Schizosaccharomyces pombe; uncharacterized protein 1512771 4987505 An14g06470 Aspergillus niger uncharacterized protein XP_001401270.1 1509053 R 5061 CDS An14g06480 4987506 join(<1513726..1513787,1514026..1514274,1514348..1514390) I 1 NT_166529.1 Protein sequence is in conflict with the conceptual translation; Function: SMD2 of S. cerevisiae is a component of the spliceosomal U1 small nuclear ribonucleoprotein complex; it is required for pre-mRNA splicing and for snRNP biogenesis.; Remark: a putative sequencing error results in a point mutation.; Remark: the systematic name for SMD2 of S. cerevisiae is YLR275W.; Title: strong similarity to small nuclear ribonucleoprotein Smd2 - Saccharomyces cerevisiae [putative sequencing error]; nucleus; putative sequencing error; uncharacterized protein 1514390 4987506 An14g06480 Aspergillus niger uncharacterized protein XP_001401271.3 1513726 D 5061 CDS An14g06490 84593056 join(1514914..1514960,1515047..1515092) I 1 NT_166529.1 Remark: the ORF is only 30 amino acids long and contains a relatively long intron.; Title: questionable ORF; uncharacterized protein 1515092 84593056 An14g06490 Aspergillus niger uncharacterized protein XP_059606466.1 1514914 D 5061 CDS An14g06500 4987508 complement(join(1515284..1515912,1515978..1516603,1516662..1517169,1517364..1517370)) I 1 NT_166529.1 Catalytic activity: glycerone kinases catalyse ATP + glycerone <=> ADP + glycerone phosphate.; Induction: DAK1 of S. pombe displayed a halometric increase in the amount of transcript, when cells were grown under high NaCl concentrations.; Similarity: the ORF overlaps with A. niger EST (EMBLEST:BE759040) an_3324.; Title: strong similarity to glycerone kinase isoform I dak1p - Schizosaccharomyces pombe; See PMID 9038161; uncharacterized protein 1517370 4987508 An14g06500 Aspergillus niger uncharacterized protein XP_001401273.1 1515284 R 5061 CDS An14g06510 84593057 complement(join(1517650..1517799,1517891..1518009,1518064..1518142,1518246..1518328,1518411..1518473,1518558..1518659,1518813..1518952,1519107..1519193,1519292..1519389)) I 1 NT_166529.1 Remark: the ORF contains relatively long introns.; hypothetical protein 1519389 84593057 An14g06510 Aspergillus niger hypothetical protein XP_059606467.1 1517650 R 5061 CDS An14g06520 4987511 complement(join(1520461..1520496,1520744..1521098,1521185..1521226,1521290..1521650,1521723..1522145,1522203..1523283,1523341..1523817)) I 1 NT_166529.1 Function: CUL-4A of H. sapiens is a member of the cullin/Cdc53 family of proteins, which are believed to function as an essential component of a multifunctional Ub-protein ligase E3 complex that has a critical role in Ub-mediated proteolysis.; Function: CUL-4A of H. sapiens is found in a complex with UV-damaged DNA-binding DDB, which is believed to be involved in DNA repair, suggesting a role for CUL-4A in cell cycle control, as found for other cullins.; Induction: human cul-4 gene is amplified and overexpressed in primary breast cancers.; Title: strong similarity to ubiquitin protein ligase CUL4A - Homo sapiens; See PMID 9721878; See PMID 10585395; uncharacterized protein 1523817 4987511 An14g06520 Aspergillus niger uncharacterized protein XP_059606468.1 1520461 R 5061 CDS An14g06530 84593058 complement(join(1524088..1524405,1524582..1524712,1524853..1525038,1525093..1525248,1525310..1529695,1529728..1529911)) I 1 NT_166529.1 Function: NUP192 of S. cerevisiae is a large yeast nucleoporin involved in mRNA export.; Remark: the systematic name for NUP192 of S. cerevisiae is YJL039C.; Similarity: the ORF and NUP192 of S. cerevisiae show local similarity (N-terminally).; Similarity: the S. pombe protein SPCC290. 03c shows strong similarity to the ORF.; Title: similarity to nucleoporin Nup192 -Saccharomyces cerevisiae; nucleus; See PMID 10428845; uncharacterized protein 1529911 84593058 An14g06530 Aspergillus niger uncharacterized protein XP_059606469.1 1524088 R 5061 CDS An14g06540 4987512 join(<1530297..1530375,1530431..1530473,1530511..1531893,1531961..1536811,1536864..1537254,1537305..>1538227) I 1 NT_166529.1 Function: TEL1 of S. cerevisiae is a member of the ATM family of genes involved in telomere length regulation.; Phenotype: the S. cerevisiae tel1rad3 double mutant grew poorly and formed irregular-shaped colonies, probably due to chromosome instability, however, during prolonged culture of the double mutant, cells forming normal round-shaped colonies arose at a relatively high frequency.; Phenotype: the S. cerevisiae tel1rad3 double mutant showed all three chromosomes in circular from, which lacked telomeric sequences.; Similarity: the similarity of the ORF to TEL1 of S. cerevisiae starts with amino acid 1782, and includes the catalytic regions of PI-kinases, the FAT and phosphotidylinositol kinase domains.; Title: strong similarity to phosphotidylinositol kinase tel1p - Schizosaccharomyces pombe; uncharacterized protein 1538227 4987512 An14g06540 Aspergillus niger uncharacterized protein XP_059606470.1 1530297 D 5061 CDS An14g06550 4987513 join(1539876..1540077,1540132..1541459) I 1 NT_166529.1 Title: strong similarity to hypothetical membrane protein YNL011c - Saccharomyces cerevisiae; uncharacterized protein 1541459 4987513 An14g06550 Aspergillus niger uncharacterized protein XP_001401278.1 1539876 D 5061 CDS An14g06560 4987514 complement(join(1541808..1545090,1545188..1545231)) I 1 NT_166529.1 Function: the function of yeast gamma DNA-polymerases is restricted to mitochondrial DNA replication and repair.; Similarity: the ORF shows similarity to several DNA polymerases from different species.; Title: strong similarity to DNA-directed DNA polymerase gamma mip1p - Schizosaccharomyces pombe; uncharacterized protein 1545231 4987514 An14g06560 Aspergillus niger uncharacterized protein XP_059606471.1 1541808 R 5061 CDS An14g06570 84593059 join(1545780..1546140,1546190..1546395) I 1 NT_166529.1 Function: COP1 of A. thaliana acts as a repressor of photomorphogenesis in darkness, probably as a negative transcription regulator.; Similarity: the C-terminus of the ORF (starting with amino acid 105) shows similarity to the zinc-finger domain of COP1 from several species.; Title: weak similarity to regulator protein COP1 -Arabidopsis thaliana; See PMID 1423630; uncharacterized protein 1546395 84593059 An14g06570 Aspergillus niger uncharacterized protein XP_059606472.1 1545780 D 5061 CDS An14g06580 4987516 join(1547635..1548704,1548810..1548928,1548982..1549055,1549104..1549156,1549204..1549257,1549306..1549408) I 1 NT_166529.1 Similarity: the ORF overlaps with A. niger EST an_1809 (EMBLEST:BE760507).; Similarity: the ORF shows similarity to some hypothetical magnesium/cobalt transporters from bacteria.; Title: similarity to hypothetical magnesium/cobalt transport protein sll0671 - Synechocystis sp.; uncharacterized protein 1549408 4987516 An14g06580 Aspergillus niger uncharacterized protein XP_059606473.1 1547635 D 5061 CDS An14g06590 4987517 complement(join(1549668..1549798,1549855..1551069,1551305..1551974)) I 1 NT_166529.1 Title: similarity to hypothetical transcription activator SPAC139.03 - Schizosaccharomyces pombe; uncharacterized protein 1551974 4987517 An14g06590 Aspergillus niger uncharacterized protein XP_059606474.1 1549668 R 5061 CDS An14g06600 4987518 complement(join(1552578..1552744,1552806..>1554012)) I 1 NT_166529.1 Remark: the predicted ORF is N-terminally truncated due to contig border.; hypothetical protein [truncated ORF] 1554012 4987518 An14g06600 Aspergillus niger hypothetical protein [truncated ORF] XP_001401283.3 1552578 R 5061 CDS An14g06610 4987519 complement(join(1554806..1555021,1555112..1555407,1555463..1556981,1557041..1557094)) I 1 NT_166529.1 Function: GTPBP1 of H. sapiens is structurally related to elongation factor 1alpha, a key component of protein biosynthesis machinery and is a member of the superfamily characterized by translation elongation factor Tu.; Induction: expression of GTPBP1 of H. sapiens is enhanced by gamma interferon in a monocytic cell line,THP-1.; Remark: GTPBP1 of H. sapiens is also called GTP-BINDING PROTEIN 1, G-PROTEIN 1, GP-1 or GP1.; Similarity: the ORF shows similarity to some translation elongation factors from different species.; Title: strong similarity to GTP-binding protein GTPBP1 - Homo sapiens; See PMID 10938096; uncharacterized protein 1557094 4987519 An14g06610 Aspergillus niger uncharacterized protein XP_001401284.3 1554806 R 5061 CDS An14g06620 4987520 complement(join(1557892..1557926,1557990..1558026,1558126..1558218,1558285..1558410)) I 1 NT_166529.1 Function: SMX4 of S. cerevisiae is, as a component of the snRNP complex, involved in nuclear pre-mRNA splicing; it coprecipitates with U4, U5 and U6 snRNAs.; Remark: SMX4 of S. cerevisiae is also called LSM3 or USS2.; Similarity: the ORF overlaps with A. niger ESTs an_2093 (EMBLEST:BE759322) and an_2787 (EMBLEST:BE759857).; Title: strong similarity to snRNP protein Smx4 -Saccharomyces cerevisiae; nucleus; See PMID 10449419; See PMID 10747033; uncharacterized protein 1558410 4987520 An14g06620 Aspergillus niger uncharacterized protein XP_001401285.1 1557892 R 5061 CDS An14g06630 4987521 join(1558879..1559617,1559662..1560929) I 1 NT_166529.1 hypothetical protein 1560929 4987521 An14g06630 Aspergillus niger hypothetical protein XP_059604693.1 1558879 D 5061 CDS An14g06640 4987522 complement(join(1561595..1562259,1562336..1562573)) I 1 NT_166529.1 Catalytic activity: PIGL of R. norvegicus catalyses the N-deacetylation of N-acetylglucosaminyl-phosphatidylinositol (GlcNAc-PI) to form glucosaminyl (GlcN)-PI.; Function: PIGL (phosphatidylinositol glycan class L) of R. norvegicus catalyses the second step of glycosylphosphatidylinositol (GPI) anchor biosynthesis, a membrane ancor for many eukaryotic cell-surface proteins.; Similarity: the ORF overlaps with A. niger EST Nig087 (EMBLEST:AN778).; Title: strong similarity to N-acetylglucosaminyl-phosphatidylinositol deacetylase PIGL - Rattus norvegicus; uncharacterized protein 1562573 4987522 An14g06640 Aspergillus niger uncharacterized protein XP_001401287.1 1561595 R 5061 CDS An14g06650 84593060 join(1563404..1563454,1563719..1563783,1564396..1564533,1564615..1564752,1564850..1565010,1565094..1565164,1565257..1565305,1565390..1565511,1566012..1566275) I 1 NT_166529.1 Remark: the intron-exon structure of the predicted ORF is suboptimal.; hypothetical protein 1566275 84593060 An14g06650 Aspergillus niger hypothetical protein XP_059604694.1 1563404 D 5061 CDS An14g06660 84593061 complement(join(1566558..1566671,1566997..1567171,1567262..1567371,1567537..1567712,1567795..1567888)) I 1 NT_166529.1 hypothetical protein 1567888 84593061 An14g06660 Aspergillus niger hypothetical protein XP_059604695.1 1566558 R 5061 CDS An14g06670 4987525 1569437..1571149 I 1 NT_166529.1 Similarity: the predicited ORF is 200 amino acids longer than SPAC1F12. 05 of S. pombe (around 100 amino acids at each end).; Title: strong similarity to hypothetical protein SPAC1F12.05 - Schizosaccharomyces pombe; uncharacterized protein 1571149 4987525 An14g06670 Aspergillus niger uncharacterized protein XP_001401290.1 1569437 D 5061 CDS An14g06680 4987526 complement(1572720..1574189) I 1 NT_166529.1 Title: strong similarity to hypothetical protein F28J12.200 - Arabidopsis thaliana; uncharacterized protein 1574189 4987526 An14g06680 Aspergillus niger uncharacterized protein XP_001401291.1 1572720 R 5061 CDS An14g06690 84593062 join(1574934..1575059,1575262..1575329,1575442..1575600,1575676..1575738,1575839..1575915,1576115..1576213,1576542..1576759) I 1 NT_166529.1 Remark: the intron-exon structure of the predicted ORF is suboptimal.; hypothetical protein 1576759 84593062 An14g06690 Aspergillus niger hypothetical protein XP_059604696.1 1574934 D 5061 CDS An14g06700 4987528 join(1577504..1577812,1578048..1579180,1579240..1579627) I 1 NT_166529.1 Catalytic activity: 4CL1 of N. tabacum converts e. g. ATP + 4-coumarate + CoA <=> AMP + diphosphate + 4-coumaroyl-CoA.; Function: 4CL1 of N. tabacum is involved in the branch-point reactions between general phenylpropanoid metabolism and pathways leading to various specific end products.; Title: strong similarity to 4-coumarate-CoA ligase 4CL1 - Nicotiana tabacum; See PMID 8819324; uncharacterized protein 1579627 4987528 An14g06700 Aspergillus niger uncharacterized protein XP_001401293.1 1577504 D 5061 CDS An14g06710 84593063 complement(join(1583149..1583190,1583317..1583707,1583797..1584049,1584457..1584493)) I 1 NT_166529.1 Remark: the intron-exon structure of the predicted ORF is suboptimal.; hypothetical protein 1584493 84593063 An14g06710 Aspergillus niger hypothetical protein XP_059604697.1 1583149 R 5061 CDS An14g06720 4987530 complement(join(1585321..1585761,1585993..1586223)) I 1 NT_166529.1 hypothetical protein 1586223 4987530 An14g06720 Aspergillus niger hypothetical protein XP_059604698.1 1585321 R 5061 CDS An14g06730 4987531 complement(join(1586688..1587713,1587769..1588254)) I 1 NT_166529.1 Function: rds1 of S. pombe is believed to mediate stress-related responses of the cell.; Induction: of S. pombe rds1 is derepressed when wild-type cells are starved for glucose, ammonium, or phosphate, under carbon dioxide atmosphere, when they are shifted to higher temperatures or when they enter the stationary phase.; Induction: the transcript of rds1 in S. pombe is greatly increased in abundance when adenine auxotrophic strains are starved for adenine.; Title: strong similarity to adenine-repressible gene rds1p - Schizosaccharomyces pombe; uncharacterized protein 1588254 4987531 An14g06730 Aspergillus niger uncharacterized protein XP_001401296.1 1586688 R 5061 CDS An14g06740 4987532 join(1589527..1589599,1589663..1590492) I 1 NT_166529.1 Catalytic activity: beta-ketoacyl reductases catalyse (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP(+) <=> 3-oxoacyl-[acyl-carrier protein] + NADPH.; Function: beta-ketoacyl reductases are required for the synthesis of the beta-hydroxy acid moiety of rhamnolipids.; Similarity: the ORF shows similarity to various oxidoreductases with different cellular functions.; Similarity: the best homologue of the ORF, B9B15. 60 of N. crassa is a probable NADPH-dependent beta-ketoacyl reductase, which is decribed to be highly similar to rhlG of P. aeruginosa.; Title: strong similarity to beta-ketoacyl reductase rhlG - Pseudomonas aeruginosa; uncharacterized protein 1590492 4987532 An14g06740 Aspergillus niger uncharacterized protein XP_001401297.1 1589527 D 5061 CDS An14g06750 4987533 complement(join(1590708..1591700,1591795..1591869)) I 1 NT_166529.1 Similarity: . the ORF shows similarity to several oxidoreductases with different cellular functions.; Title: strong similarity to hypothetical oxidoreductase PA0147 - Pseudomonas aeruginosa; uncharacterized protein 1591869 4987533 An14g06750 Aspergillus niger uncharacterized protein XP_001401298.1 1590708 R 5061 CDS An14g06760 4987534 join(1592609..1593599,1593653..1593813) I 1 NT_166529.1 Similarity: the ORF shows some similarity to A. niger 2,3-dihydroxybenzoic acid decarboxylase (PATENTPROT:AAW93483).; Title: similarity to hypothetical conserved protein SCIF3.07c - Streptomyces coelicolor; uncharacterized protein 1593813 4987534 An14g06760 Aspergillus niger uncharacterized protein XP_001401299.1 1592609 D 5061 CDS An14g06770 4987535 complement(join(1594027..1595592,1595635..1595709)) I 1 NT_166529.1 hypothetical protein 1595709 4987535 An14g06770 Aspergillus niger hypothetical protein XP_059604699.1 1594027 R 5061 CDS An14g06780 4987536 1596435..1597757 I 1 NT_166529.1 Function: hsp40 of H. sapiens is an abundant chaperone, which can stimulate the ATPase activity of hsp70 and the association between hsc70 and hip.; Remark: hsp40 of H. sapiens is also called DNAJB1,HSPF1, DNAJ1 or HDJ1.; Similarity: the ORF shows strong similarity to J-domains of several DNA-J heat-shock proteins.; Title: strong similarity to heat-shock protein Hsp40 - Homo sapiens; See PMID 10830586; uncharacterized protein 1597757 4987536 An14g06780 Aspergillus niger uncharacterized protein XP_001401301.1 1596435 D 5061 CDS An14g06790 4987537 complement(1598023..1599357) I 1 NT_166529.1 Similarity: the ORF shows similarity to CAF17 of S. cerevisiae, which is predicted to be a CCR4 transcriptional complex component.; Title: strong similarity to hypothetical protein SPAC21E11.07 - Schizosaccharomyces pombe; uncharacterized protein 1599357 4987537 An14g06790 Aspergillus niger uncharacterized protein XP_001401302.3 1598023 R 5061 CDS An14g06800 4987538 complement(join(1599637..1602149,1602236..1602266)) I 1 NT_166529.1 Function: DCP2 of S. cerevisiae is involved in mRNA degradation in yeast by mRNA decapping.; Remark: DCP2 of S. cerevisiae was also called YNL118C or PSU1, but PSU1 is also taken for a transcription activator protein.; Title: strong similarity to mRNA decapping protein Dcp2 - Saccharomyces cerevisiae; See PMID 10508173; See PMID 11139489; uncharacterized protein 1602266 4987538 An14g06800 Aspergillus niger uncharacterized protein XP_059604700.1 1599637 R 5061 CDS An14g06810 4987539 join(1603161..1603292,1603473..1603523,1603561..1604082) I 1 NT_166529.1 Title: strong similarity to hypothetical protein EAA65239.1 - Aspergillus nidulans; uncharacterized protein 1604082 4987539 An14g06810 Aspergillus niger uncharacterized protein XP_059604701.1 1603161 D 5061 CDS An14g06820 4987540 complement(join(1604173..1605187,1605259..1605344)) I 1 NT_166529.1 Function: SPBC19C2. 13c of S. pombe is believed to be involved in cytoplasmic ribosome function.; Title: similarity to hypothetical protein SPBC19C2.13c - Schizosaccharomyces pombe; uncharacterized protein 1605344 4987540 An14g06820 Aspergillus niger uncharacterized protein XP_001401305.1 1604173 R 5061 CDS An14g06830 4987541 join(1605785..1605859,1605919..1606116,1606181..1606506,1606562..1606602,1606652..1606726,1606777..1607387,1607444..1607728) I 1 NT_166529.1 Title: strong similarity to hypothetical membrane protein Ptm1 - Saccharomyces cerevisiae; uncharacterized protein 1607728 4987541 An14g06830 Aspergillus niger uncharacterized protein XP_001401306.3 1605785 D 5061 CDS An14g06840 4987542 1608999..1610588 I 1 NT_166529.1 hypothetical protein 1610588 4987542 An14g06840 Aspergillus niger hypothetical protein XP_001401307.1 1608999 D 5061 CDS An14g06850 4987543 complement(join(1610699..1611480,1611534..1611759,1611822..1611926)) I 1 NT_166529.1 Remark: WD domains are a characteristic motifs in beta-transducin, the beta1-subunit of the signal-transducing G proteins.; Title: strong similarity to hypothetical WD-repeat protein - Ajellomyces capsulatus; uncharacterized protein 1611926 4987543 An14g06850 Aspergillus niger uncharacterized protein XP_001401308.1 1610699 R 5061 CDS An14g06860 4987544 join(1612353..1612632,1612761..1612990,1613044..1613515,1613566..1613711,1613769..1613861) I 1 NT_166529.1 Function: OAC1 of S. cerevisiae is an oxaloacetate carrier, which is responsible for the uptake of oxaloacetate into mitochondria produced from pyruvate by cytoplasmic pyruvate carboxylase.; Phenotype: deletion of the OAC1 gene in S. cerevisiae reduces transport of oxaloacetate sulfate,thiosulfate, and malonate into mitochondria, where as mitochondria from wild-type cells swell in isoosmotic solutions of ammonium salts of oxaloacetate, sulfate,thiosulfate, and malonate, indicating that these anions are cotransported with protons.; Remark: OAC1 of S. cerevisiae is also called YKL120W, YKL522 or PMT1, but PMT1 is also used for an dolichyl-phosphate-mannose--protein mannosyltransferase.; Similarity: the predicted ORF is 78 amino acids longer at the N-termnus than OAC1 of S. cerevisiae.; Title: strong similarity to oxaloacetate transporter Oac1 - Saccharomyces cerevisiae; See PMID 10428783; uncharacterized protein 1613861 4987544 An14g06860 Aspergillus niger uncharacterized protein XP_059604702.1 1612353 D 5061 CDS An14g06870 4987545 join(1615712..1615741,1615822..1616052,1616157..1616490,1616544..1617139) I 1 NT_166529.1 Catalytic activity: ribonucleotide reductases catalyse 2'deoxyribonucleoside diphosphate + oxidized thioredoxin + H(2)O <=> ribonucleoside diphosphate + reduced thioredoxin.; Function: SUC22 of S. pombe catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides, the first step necessary for DNA synthesis.; Phenotype: disruption SUC22 in S. pombe is lethal.; Remark: SUC22 of S. pombe is also called SPBC25D12. 04.; Title: strong similarity to ribonucleotide reductase suc22p - Schizosaccharomyces pombe; See PMID 8842148; uncharacterized protein 1617139 4987545 An14g06870 Aspergillus niger uncharacterized protein XP_001401310.1 1615712 D 5061 CDS An14g06880 4987546 complement(join(1617594..1618031,1618107..1618373,1618559..1618610,1618675..1620347,1620407..1620947,1621118..1621281,1621357..1621523,1621713..1621923)) I 1 NT_166529.1 Similarity: the ORF shows strong similarity to several proteins with WD-40 repeat domains.; Similarity: the predicted ORF is 235 amino acids longer at the C-terminus than S. pombe SPAC3H5. 08c.; Title: strong similarity to hypothetical beta-transducin SPAC3H5.08c - Schizosaccharomyces pombe; uncharacterized protein 1621923 4987546 An14g06880 Aspergillus niger uncharacterized protein XP_059604703.1 1617594 R 5061 CDS An14g06890 4987547 complement(join(<1623207..1624302,1624355..1624540,1624593..1624732,1624779..1624902)) I 1 NT_166529.1 Remark: QUTD gene encodes an essential component of a permease required for transport of quinate ion into mycelium at pH 6. 5. The QUTD gene has been located within the cloned QUT gene cluster of A. nidulans.; Remark: the A. niger ORF contains a putative sequencing error at position 13394.; Similarity: belongs to the sugar transporter family.; Title: strong similarity to quinate transport protein qutD - Aspergillus nidulans [putative frameshift]; putative frameshift; See PMID 2835177; See PMID 2976880; uncharacterized protein 1624902 4987547 An14g06890 Aspergillus niger uncharacterized protein XP_059604704.1 1623207 R 5061 CDS An14g06900 4987548 join(1625840..1626398,1626476..1626516) I 1 NT_166529.1 Title: similarity to hypothetical protein encoded by An13g01780 - Aspergillus niger; uncharacterized protein 1626516 4987548 An14g06900 Aspergillus niger uncharacterized protein XP_001401313.3 1625840 D 5061 CDS An14g06910 4987549 complement(1626751..1627428) I 1 NT_166529.1 Catalytic activity: RX+glutathione<=>HX+R-S-glutathione.; Complex: the gluthathione S-transferase III from Zea may forms a homodimer.; Function: the gluthathione S-transferase III from Zea mays conjugates reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and is involved in the detoxification of certain herbicides.; Title: similarity to gluthathione S-transferase III GST3 - Zea mays; See PMID 3277162; See PMID 3532034; uncharacterized protein 1627428 4987549 An14g06910 Aspergillus niger uncharacterized protein XP_001401314.1 1626751 R 5061 CDS An14g06920 4987550 join(1628587..1628838,1628901..1629551) I 1 NT_166529.1 Title: strong similarity to hypothetical protein 4 -Streptomyces coelicolor; uncharacterized protein 1629551 4987550 An14g06920 Aspergillus niger uncharacterized protein XP_001401315.1 1628587 D 5061 CDS An14g06930 4987551 complement(join(1629760..1630067,1630131..1630268,1630328..1630696,1630771..1631023)) I 1 NT_166529.1 Catalytic activity: ARII of S. salmonicolor catalyzes the reaction of ethyl 4-chloro-3-oxobutanoate (4-COBE) to ethyl (S)-4-chloro-3-hydroxybutanoate.; Similarity: ARII of S. salmonicolor exhibited significant levels of similarity to the amino acid sequences of members of the mammalian 3-hydroxysteroid dehydrogenase-plant dihydroflavonol 4-reductase superfamily but not to the amino acid sequences of members of the aldo-keto reductase superfamily or to the amino acid sequence of an aldehyde reductase previously isolated from the same organism.; Similarity: the A. niger protein also shows similarity to other reductases.; Title: strong similarity to aldehyde reductase II ARII - Sporidiobolus salmonicolor; See PMID 10583966; uncharacterized protein 1631023 4987551 An14g06930 Aspergillus niger uncharacterized protein XP_001401316.1 1629760 R 5061 CDS An14g06940 4987552 join(1632029..1632252,1632324..1632597,1632648..1632733,1632814..1633187,1633428..1633547,1633607..1633891,1633959..1634405,1634646..1635073) I 1 NT_166529.1 Remark: the A. niger protein shows weak similarity to several transcription factors and contains a Fungal Zn(2)-Cys(6) binuclear cluster (according to PFAM, PROSITE and BLOCKS).; Title: weak similarity to protein PRIB - Lentinus edodes; nucleus; uncharacterized protein 1635073 4987552 An14g06940 Aspergillus niger uncharacterized protein XP_059604705.1 1632029 D 5061 CDS An14g06950 4987553 join(1635239..1635290,1635352..1635512,1635580..1635993,1636047..1636176,1636245..1636490,1636589..1636636,1636688..1637253) I 1 NT_166529.1 Function: C. albicans Flu1 is an efflux transporter involved in drug resistance.; Remark: expression of the C. albicans FLU1 gene in S. cerevisiae mediated not only resistance to fluconazole but also to cycloheximide.; Similarity: C. albicans Flu1 is a multidrug efflux transporter gene of the major facilitator superfamily.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353; uncharacterized protein 1637253 4987553 An14g06950 Aspergillus niger uncharacterized protein XP_001401318.1 1635239 D 5061 CDS An14g06960 4987554 join(1638034..1638162,1638221..1638378,1638433..1638802) I 1 NT_166529.1 hypothetical protein 1638802 4987554 An14g06960 Aspergillus niger hypothetical protein XP_001401319.1 1638034 D 5061 CDS An14g06970 4987555 1639134..1640966 I 1 NT_166529.1 Title: strong similarity to hypothetical protein Rv3762c - Mycobacterium tuberculosis; uncharacterized protein 1640966 4987555 An14g06970 Aspergillus niger uncharacterized protein XP_001401320.1 1639134 D 5061 CDS An14g06980 4987556 join(1641851..1641889,1641969..1642767,1642834..1643192) I 1 NT_166529.1 Catalytic activity: delta-12 fatty acid desaturase of M. alpina catalyzes the desaturation of oleic acid (Delta9-18 : 1) to linoleic acid (Delta9, Delta12 : 2).; Title: strong similarity to delta-12 fatty acid desaturase - Mortierella alpina; See PMID 10215899; uncharacterized protein 1643192 4987556 An14g06980 Aspergillus niger uncharacterized protein XP_001401321.1 1641851 D 5061 CDS An14g06990 84593064 complement(join(1643402..1643460,1643506..1643722)) I 1 NT_166529.1 hypothetical protein 1643722 84593064 An14g06990 Aspergillus niger hypothetical protein XP_059604706.1 1643402 R 5061 CDS An14g07000 84593065 1644578..1645513 I 1 NT_166529.1 Title: similarity to hypothetical protein encoded by An11g09000 - Aspergillus niger; uncharacterized protein 1645513 84593065 An14g07000 Aspergillus niger uncharacterized protein XP_059604707.1 1644578 D 5061 CDS An14g07010 4987559 join(1646113..1646188,1646248..1646705,1646781..1646961,1647031..1647141,1647190..1647323) I 1 NT_166529.1 Remark: the A. niger protein shows similarity to many hypothetical reductases and contains a short chain dehydrogenase PFAM domain.; Remark: the patented arabidopsis protein has not been described.; Title: strong similarity to protein fragment SEQ ID NO:61122 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 1647323 4987559 An14g07010 Aspergillus niger uncharacterized protein XP_001401324.1 1646113 D 5061 CDS An14g07020 84593066 complement(join(1647467..1648012,1648126..1648639,1648743..1649008)) I 1 NT_166529.1 Title: weak similarity to hypothetical cysteine-binding protein fliY - Haloferax volcanii; uncharacterized protein 1649008 84593066 An14g07020 Aspergillus niger uncharacterized protein XP_059604708.1 1647467 R 5061 CDS An14g07030 4987561 complement(join(1649149..1649377,1649428..1650830)) I 1 NT_166529.1 Function: B. subtilis PNB carboxy-esterase catalyzes hydrolysis of several beta-lactam antibiotic PNB esters to the corresponding free acid and PNB alcohol.; Similarity: the A. niger protein also shows strong similarity to other ester hydrolases.; Title: strong similarity to p-nitrobenzyl esterase pnbA - Bacillus subtilis; See PMID 7828905; uncharacterized protein 1650830 4987561 An14g07030 Aspergillus niger uncharacterized protein XP_001401326.1 1649149 R 5061 CDS An14g07040 4987562 join(1651571..1651663,1651874..1653040) I 1 NT_166529.1 Title: similarity to gene expression regulator At14 from patent WO200257456-A2 - Unclassified organism; nucleus; uncharacterized protein 1653040 4987562 An14g07040 Aspergillus niger uncharacterized protein XP_001401327.1 1651571 D 5061 CDS An14g07050 4987563 complement(join(1653201..1653904,1654002..1654188)) I 1 NT_166529.1 Function: RTA1 of S. cerevisiae confers resistance to 7-aminocholesterol, a strong inhibitor of yeast and of Gram+-bacteria proliferation.; Remark: the protein shows also strong similarity to molasses toxicity resisitance protein RTM1 from S. cerevisiae patent WO9514774-A2.; Title: similarity to 7-aminocholesterol resistance protein Rta1 - Saccharomyces cerevisiae; See PMID 8660468; uncharacterized protein 1654188 4987563 An14g07050 Aspergillus niger uncharacterized protein XP_001401328.1 1653201 R 5061 CDS An14g07060 4987564 complement(join(1654843..1655045,1655133..1655247,1655304..1655639)) I 1 NT_166529.1 Function: FRM2 of yeast functions in the fatty acid signalling pathway and is itself regulated by fatty acids.; Remark: A better BlastpPATENT hit was not annotated as a clear function could not be identified for it.; Title: strong similarity to fatty acid regulation protein Frm2 - Saccharomyces cerevisiae; See PMID 8701605; uncharacterized protein 1655639 4987564 An14g07060 Aspergillus niger uncharacterized protein XP_001401329.1 1654843 R 5061 CDS An14g07070 4987565 complement(join(1656959..1657049,1657212..1657294,1657330..1657483,1657570..1657960,1658061..1658127,1658187..1658231,1658309..1658850,1658955..1659003)) I 1 NT_166529.1 Title: similarity to hypothetical hsp70-like protein CAB91447.2 - Neurospora crassa; uncharacterized protein 1659003 4987565 An14g07070 Aspergillus niger uncharacterized protein XP_059604709.1 1656959 R 5061 CDS An14g07080 4987566 join(1659840..1660404,1660556..1661238) I 1 NT_166529.1 Title: similarity to hypothetical protein encoded by An14g06130 - Aspergillus niger [putative sequencing error]; putative sequencing error; uncharacterized protein 1661238 4987566 An14g07080 Aspergillus niger uncharacterized protein XP_059604710.1 1659840 D 5061 CDS An14g07090 4987567 complement(join(1662149..1662399,1662461..1662572,1662647..1662806,1662857..1664036,1664147..1664186)) I 1 NT_166529.1 Title: similarity to hypothetical Hsp70-like protein CAB91447.2 - Neurospora crassa; uncharacterized protein 1664186 4987567 An14g07090 Aspergillus niger uncharacterized protein XP_059604711.1 1662149 R 5061 CDS An14g07100 84593067 1665210..1666589 I 1 NT_166529.1 Title: strong similarity to hypothetical protein encoded by An09g02660 - Aspergillus niger; uncharacterized protein 1666589 84593067 An14g07100 Aspergillus niger uncharacterized protein XP_059604712.1 1665210 D 5061 CDS An14g07110 84593068 complement(join(1667395..1667586,1667658..1667703,1667723..1667910,1668193..1668261)) I 1 NT_166529.1 hypothetical protein 1668261 84593068 An14g07110 Aspergillus niger hypothetical protein XP_059604713.1 1667395 R 5061 CDS An14g07120 84593069 join(1669096..1669225,1669368..1669463,1669577..1669722) I 1 NT_166529.1 hypothetical protein 1669722 84593069 An14g07120 Aspergillus niger hypothetical protein XP_059604714.1 1669096 D 5061 CDS An14g07130 4987571 join(1671889..1672072,1672151..1672223,1672287..1672618,1672697..1672840,1672903..1673117,1673189..1673386,1673453..1673480,1673538..1673653,1673714..1673803) I 1 NT_166529.1 Function: mtr of N. crassa is required for the transport of neutral aliphatic and aromatic amino acids via the N system.; Title: strong similarity to neutral amino acid permease mtr - Neurospora crassa; See PMID 8001794; uncharacterized protein 1673803 4987571 An14g07130 Aspergillus niger uncharacterized protein XP_001401336.1 1671889 D 5061 CDS An14g07140 4987572 1675236..1676159 I 1 NT_166529.1 Function: HOC1 of S. cerevisiae is involved in N-glycan processing of proteins, especially cell wall mannoprotein biosynthesis.; Golgi; Phenotype: the S. cerevisiae HOC1 null mutant is viable but is hypersensitive to calcofluor white and hygromycin B and has lowered restrictive temperature in a pkc1-371 background.; Remark: the systematic name for HOC1 of S. cerevisiae is YJR075W.; Similarity: the predicted ORF is 83 amino acids shorter at the N-terminus than HOC1 of S. cerevisiae; the homology starts with amino acid 105.; Title: strong similarity to alpha-1,6-mannosyltransferase Hoc1 - Saccharomyces cerevisiae; See PMID 9055074; See PMID 9434768; uncharacterized protein 1676159 4987572 An14g07140 Aspergillus niger uncharacterized protein XP_001401337.1 1675236 D 5061 CDS An14g07150 4987573 complement(join(1676374..1676534,1676608..1676712,1676778..1677120)) I 1 NT_166529.1 hypothetical protein 1677120 4987573 An14g07150 Aspergillus niger hypothetical protein XP_001401338.3 1676374 R 5061 CDS An14g07160 4987574 1677968..1679647 I 1 NT_166529.1 hypothetical protein 1679647 4987574 An14g07160 Aspergillus niger hypothetical protein XP_001401339.1 1677968 D 5061 CDS An14g07170 84593070 complement(join(1680208..1680647,1680939..1680963)) I 1 NT_166529.1 Remark: the intron is unusually long.; Title: questionable ORF; uncharacterized protein 1680963 84593070 An14g07170 Aspergillus niger uncharacterized protein XP_059604715.1 1680208 R 5061 CDS An14g07180 4987576 complement(1682735..1683775) I 1 NT_166529.1 Catalytic activity: alcolhol dehydrogenases catalyse an alcohol + NAD(+) <=> an aldehyde or ketone + NADH.; Function: alcolhol dehydrogenases are involved in various cellular processes, which require the reversible oxidation of ethanol to acetaldehyde.; Similarity: the ORF shows strong similarity to various alcohol dehydrogenases from several species,especially from bacteria.; Title: strong similarity to thermostable alcohol dehydrogenase adhT - Bacillus stearothermophilus; See PMID 10971204; See PMID 436831; See PMID 1735726; uncharacterized protein 1683775 4987576 An14g07180 Aspergillus niger uncharacterized protein XP_001401341.1 1682735 R 5061 CDS An14g07190 4987577 complement(join(1684313..1684465,1684679..1684975,1685029..1685624,1685694..1685994,1686054..1686203)) I 1 NT_166529.1 Title: similarity to hypothetical protein CAD21260.1 - Neurospora crassa; uncharacterized protein 1686203 4987577 An14g07190 Aspergillus niger uncharacterized protein XP_059604716.1 1684313 R 5061 CDS An14g07200 4987578 complement(join(1686400..1686878,1686933..1687017,1687087..1687506,1687570..1687662,1687720..1687954,1688029..1688158,1688220..1688250)) I 1 NT_166529.1 Catalytic activity: catalases convert 2 H(2)O(2) <=> O(2) + 2 H(2)O.; Function: catC of A. nidulans is involved in the detoxification of hydrogen peroxide, which is a fundamental aspect of the cellular antioxidant responses in amost all aerobically respiring organisms to protect cells.; Title: strong similarity to catalase C catC -Aspergillus nidulans; See PMID 11157957; uncharacterized protein 1688250 4987578 An14g07200 Aspergillus niger uncharacterized protein XP_001401343.1 1686400 R 5061 CDS An14g07210 4987579 join(1690633..1690950,1691013..1691065,1691120..1691819,1691895..1692155) I 1 NT_166529.1 Catalytic activity: hisD of E. coli catalyses L-histidinol + 2 NAD(+) + H(2)O <=> L-histidine + 2 NADH.; Function: hisD of E. coli catalyzes the terminal step in the biosynthesis of histidine, the four-electron oxidation of L-histidinol to histidine.; Remark: hisD of E. coli is also called HDH.; Title: strong similarity to histidinol dehydrogenase hisD - Escherichia coli; uncharacterized protein 1692155 4987579 An14g07210 Aspergillus niger uncharacterized protein XP_059604717.1 1690633 D 5061 CDS An14g07220 4987580 1692682..1693560 I 1 NT_166529.1 Function: the owner of the patent WO200055180-A2 (PATENTPROT:AAB58229) claims, that lung cancer associated proteins and polynucleotide sequences, their agonists, and antagonists may have neuroprotective; cytostatic; cardioactive; immunomodulatory; muscular active general; vulnerary; gastrointestinal general; nephrotropic; antiinfective; gynecological; or antibacterial activity.; Title: similarity to lung cancer associated polypeptide sequence SEQ ID NO:567 from patent WO200055180-A2 - Homo sapiens; uncharacterized protein 1693560 4987580 An14g07220 Aspergillus niger uncharacterized protein XP_001401345.1 1692682 D 5061 CDS An14g07230 4987581 complement(1694423..1695649) I 1 NT_166529.1 Title: similarity to hypothetical protein encoded by An15g00800 - Aspergillus niger; uncharacterized protein 1695649 4987581 An14g07230 Aspergillus niger uncharacterized protein XP_001401346.1 1694423 R 5061 CDS An14g07240 4987582 complement(1696957..1697388) I 1 NT_166529.1 Function: ankyrins attach integral membrane proteins to cytoskeletal elements; they bind to Na-K ATPase and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin.; Similarity: the predicted ORF shows similarity to several ankyrins and ankyrin-like proteins.; Title: similarity to ankyrin Ank2 - Homo sapiens; uncharacterized protein 1697388 4987582 An14g07240 Aspergillus niger uncharacterized protein XP_001401347.3 1696957 R 5061 CDS An14g07250 84593071 join(1697917..1697964,1698050..1698365,1698416..1698651) I 1 NT_166529.1 hypothetical protein 1698651 84593071 An14g07250 Aspergillus niger hypothetical protein XP_059604718.1 1697917 D 5061 CDS An14g07260 4987584 1699050..1700681 I 1 NT_166529.1 Function: eln2 of C. cinereus encodes a novel type of microsomal cytochrome P450 enzyme, which is involved in mushroom morphogenesis.; Localization: C. cinereus eln2 localises to the microsomal compartment.; Phenotype: a dominant mutation of the elongationless2 (eln2) gene of the mushroom C. cinereus affects pattern formation in the development of fruit body primordia, causing dumpy primordia which culminate in mature fruit bodies with short stipes.; Similarity: the ORF shows similarity to several cytochrome p450 related proteins from different species,which have different cellular functions.; Title: strong similarity to cytochrome P450 eln2 -Coprinus cinereus; uncharacterized protein 1700681 4987584 An14g07260 Aspergillus niger uncharacterized protein XP_001401349.1 1699050 D 5061 CDS An14g07270 4987585 join(1701801..1701962,1702015..1702199,1702260..1702917) I 1 NT_166529.1 Catalytic activity: 1-haloalkane + H(2)O <=> a primary alcohol + halide.; Function: the X. autotrophicus homolog dhmA is an enzyme involved in detoxification of halogenated alkanes,catalyzes cleavage of carbon-halogene bond in halogenated hydrocarbons.; Remark: haloalkane dehalogenases act on a wide range of 1-haloalkanes, haloalcohols, haloalkenes and some haloaromatic compounds.; Similarity: similarity to subfamily of epoxid hydrolases.; Title: similarity to haloalkane dehalogenase dhlA -Xanthobacter autotrophicus; uncharacterized protein 1702917 4987585 An14g07270 Aspergillus niger uncharacterized protein XP_001401350.3 1701801 D 5061 CDS An14g07280 84593072 complement(join(1703680..1704426,1704479..1704544)) I 1 NT_166529.1 Title: weak similarity to hypothetical protein K07E12.1 - Caenorhabditis elegans; uncharacterized protein 1704544 84593072 An14g07280 Aspergillus niger uncharacterized protein XP_059604719.1 1703680 R 5061 CDS An14g07300 4987587 1706931..1707662 I 1 NT_166529.1 Title: strong similarity to hypothetical protein CAD70322.1 - Neurospora crassa; uncharacterized protein 1707662 4987587 An14g07300 Aspergillus niger uncharacterized protein XP_001401352.1 1706931 D 5061 CDS An14g07310 84593073 complement(join(1709406..1710189,1710331..1710380)) I 1 NT_166529.1 Remark: the N. crassa homolog B23L21. 350 might be related to the host-specific AK-toxin Akt2.; Title: similarity to hypothetical protein B23L21.350 - Neurospora crassa; uncharacterized protein 1710380 84593073 An14g07310 Aspergillus niger uncharacterized protein XP_059604720.1 1709406 R 5061 CDS An14g07320 4987589 join(1711790..1711872,1711985..1712648,1712707..1712950,1713043..1713532,1713721..1713742,1713774..1713827) I 1 NT_166529.1 Function: the cytochrome P450 enzymes usually act as terminal oxidases in multicomponent electron transfer chains, called P450-containing monooxygenase systems.; Pathway: Aflatoxin pathway.; Remark: the avnA gene of A. parasiticus encodes a fungal cytochrome P-450-type enzyme which is involved in the conversion of averantin to averufin in the aflatoxin biosynthetic pathway in A. parasiticus.; Similarity: shows similarity to several cytochrome P450 monooxygenases.; Title: strong similarity to cytochrome P450 monooxygenase avnA - Aspergillus parasiticus; uncharacterized protein 1713827 4987589 An14g07320 Aspergillus niger uncharacterized protein XP_059604721.1 1711790 D 5061 CDS An14g07330 4987590 complement(join(1713918..1714139,1714201..1714307,1714364..1714609,1714664..1714799,1714856..1715013,1715071..1715185,1715236..1715433,1715488..1715796)) I 1 NT_166529.1 Title: strong similarity to hypothetical protein ybiU - Escherichia coli; uncharacterized protein 1715796 4987590 An14g07330 Aspergillus niger uncharacterized protein XP_001401355.1 1713918 R 5061 CDS An14g07340 84593074 complement(join(1715820..1716024,1716111..1716212,1716474..1716624,1716847..1716978,1717038..1717154,1717583..1717694)) I 1 NT_166529.1 hypothetical protein 1717694 84593074 An14g07340 Aspergillus niger hypothetical protein XP_059604722.1 1715820 R 5061 CDS An14g07350 4987592 complement(join(1717791..1718250,1718353..1718828,1718883..1719160,1719263..1719365)) I 1 NT_166529.1 Title: strong similarity to hypothetical protein ybiU - Escherichia coli; uncharacterized protein 1719365 4987592 An14g07350 Aspergillus niger uncharacterized protein XP_059604723.1 1717791 R 5061 CDS An14g07360 4987593 complement(1720966..1722822) I 1 NT_166529.1 Function: the A. parasiticus homolog aflR is a Zn2Cys6-type sequence-specific DNA-binding protein that is thought to be necessary for expression of most of the genes in the aflatoxin pathway gene cluster.; Similarity: the ORF encoded protein shows significant domain homology to binuclear Zn(2)-Cys(6) cluster domains of many fungal transcription factors.; Title: similarity to aflatoxin biosynthesis regulatory protein aflR - Aspergillus parasiticus; uncharacterized protein 1722822 4987593 An14g07360 Aspergillus niger uncharacterized protein XP_001401358.1 1720966 R 5061 CDS An14g07370 4987594 complement(1723003..1723497) I 1 NT_166529.1 Title: strong similarity to hypothetical protein EAA60648.1 - Aspergillus nidulans; uncharacterized protein 1723497 4987594 An14g07370 Aspergillus niger uncharacterized protein XP_059604724.1 1723003 R 5061 CDS An14g07380 4987595 join(1724007..1724286,1724319..1725025) I 1 NT_166529.1 Similarity: has similarity to superfamily of alcohol dehydrogenases.; Title: strong similarity to hypothetical zinc-binding oxidoreductase BAB49325.1 - Mesorhizobium loti; uncharacterized protein 1725025 4987595 An14g07380 Aspergillus niger uncharacterized protein XP_059604725.1 1724007 D 5061 CDS An14g07390 4987596 complement(join(1725541..1725946,1725998..1726227)) I 1 NT_166529.1 Catalytic activity: endohydrolysis of 1,4-beta-d-xylosidic linkages in xylans.; Pathway: xylan degradation.; Remark: A. niger XYN1 has a low pH optimum.; Similarity: belongs to cellulase family g (family 11 of glycosyl hydrolases).; Title: strong similarity to endo-1,4-beta-xylanase I xyn1 - Aspergillus niger; extracellular/secretion proteins; uncharacterized protein 1726227 4987596 An14g07390 Aspergillus niger uncharacterized protein XP_001401361.1 1725541 R 5061 CDS An14g07400 4987597 join(1729014..1729164,1729198..1729684,1729732..1730107) I 1 NT_166529.1 Title: strong similarity to hypothetical protein encoded by An14g07410 - Aspergillus niger; uncharacterized protein 1730107 4987597 An14g07400 Aspergillus niger uncharacterized protein XP_059604726.1 1729014 D 5061 CDS An14g07420 84593075 complement(1731202..>1734209) I 3 NT_166529.1 Catalytic activity: hydrolysis of the 1,4-beta-linkages of N-acetyl-D-glucosamine polymers of chitin.; Remark: truncated due to end of contig.; Similarity: belongs to the chitinase family.; Title: strong similarity to chitinase chiC -Aspergillus nidulans [truncated ORF] [putative sequencing error]; putative sequencing error; uncharacterized protein 1734209 84593075 An14g07420 Aspergillus niger uncharacterized protein XP_059604727.1 1731202 R 5061 CDS An01g00010 84589810 join(<134..282,484..700) II 1 NT_166518.1 Remark: 5' truncated ORF due to end of contig.; hypothetical protein [truncated ORF] 700 84589810 An01g00010 Aspergillus niger hypothetical protein [truncated ORF] XP_059599562.1 134 D 5061 CDS An01g00020 84589811 join(1295..1387,1687..1968) II 1 NT_166518.1 Function: E. coli PhnN protein is a member of the nucleotide-binding proteins of the binding protein-dependent transport systems.; Remark: blastp shows possibly significant similarity (47% positives) between predicted A. niger protein and E. coli phnN but due to shortness of both peptides the probability is low (p=7,1).; Title: weak similarity to nucleotide binding protein phnN - Escherichia coli; uncharacterized protein 1968 84589811 An01g00020 Aspergillus niger uncharacterized protein XP_059599563.1 1295 D 5061 CDS An01g00030 4978422 join(2871..2891,2969..3014,3129..3232,3310..3423,3481..4272) II 1 NT_166518.1 Function: Disruption of S. cerevisiae HGH1 reveals no basic phenotypes.; Remark: S. cerevisiae HGH1 was cloned from cDNA and shows similarity to human non-histone linker DNA-binding proteins of the HMG1 family.; Title: strong similarity to Hgh1 - Saccharomyces cerevisiae; See PMID 9818723; uncharacterized protein 4272 4978422 An01g00030 Aspergillus niger uncharacterized protein XP_001388455.1 2871 D 5061 CDS An01g00040 4978366 5250..>6158 II 1 NT_166518.1 Function: in S. cerevisiae TFIIF is required for initiation at most, if not all, polymerase II promoters and probably contains three subunits in yeast, alpha, beta and a small subunit.; Remark: ORF 3'truncated due to end of contig.; Title: strong similarity to alpha subunit of transcription initiation factor TFIIF Tfg1 - Saccharomyces cerevisiae [truncated ORF]; localisation:nucleus; See PMID 7995524; uncharacterized protein 6158 4978366 An01g00040 Aspergillus niger uncharacterized protein XP_001388456.3 5250 D 5061 CDS An01g00050 4978516 complement(<6263..9904) II 1 NT_166518.1 Catalytic activity: Acetyl-CoA + N malonyl-CoA + 2 NADH + 2 NADPH = a long-chain acyl-CoA + N CoA + N CO(2) + N NAD(+) + N NADP(+).; Remark: C-terminally truncated due to contig border.; Remark: FAS1 is a pentafunctional enzyme consisting of the following domains: acetyl transferase, enoyl reductase, dehydratase and malonyl/palmityl transferase.; Title: similarity to fatty-acyl-CoA synthase beta chain Fas1 - Saccharomyces cerevisiae [truncated ORF]; See PMID 3031066; See PMID 3528750; uncharacterized protein 9904 4978516 An01g00050 Aspergillus niger uncharacterized protein XP_001388457.3 6263 R 5061 CDS An01g00060 4978430 join(12561..13089,13163..18111,18171..18281) II 1 NT_166518.1 Catalytic activity: Acetyl-CoA + n Malonyl-CoA + 2n NADPH = long-chain fatty acid + (n+1) CoA + n CO(2) + 2n NADP(+).; Complex: Fatty acid synthetase is composed of [alpha(6)beta(6)] hexamers of the two multifunctional subunits FAS1 (alpha) and FAS2 (beta).; Title: strong similarity to fatty acid synthase alpha subunit fas2p - Schizosaccharomyces pombe; See PMID 9693066; uncharacterized protein 18281 4978430 An01g00060 Aspergillus niger uncharacterized protein XP_001388458.1 12561 D 5061 CDS An01g00070 84589812 complement(join(18722..18857,19125..19374,19477..20168,20214..20794)) II 1 NT_166518.1 Catalytic activity: S-Adenosyl-l-Methionine + tRNA = S-Adenosyl-l-Homocysteine + tRNA containing n(2)-Methylguanine.; Function: trm1 dimethylates a single guanine residue at position 26 of most tRNAs using S-Adenosyl-l -Methionine as donor of the methyl groups.; Remark: In the majority of eukaryotic tRNAs, the guanosine at position 26 is modified by a dimethyl group.; Title: strong similarity to N2,N2-dimethylguanosine tRNA methyltransferase trm1p - Schizosaccharomyces pombe; See PMID 10611485; uncharacterized protein 20794 84589812 An01g00070 Aspergillus niger uncharacterized protein XP_059599565.1 18722 R 5061 CDS An01g00080 4977893 complement(join(21259..22046,22133..22367)) II 1 NT_166518.1 Title: weak similarity to hypothetical membrane protein YOR228c - Saccharomyces cerevisiae; uncharacterized protein 22367 4977893 An01g00080 Aspergillus niger uncharacterized protein XP_001388459.3 21259 R 5061 CDS An01g00090 4978397 join(22991..23035,23124..23744) II 1 NT_166518.1 Title: weak similarity to secreted protein SEQ ID NO:901 from patent WO200155322-A2 - Homo sapiens; uncharacterized protein 23744 4978397 An01g00090 Aspergillus niger uncharacterized protein XP_001388461.1 22991 D 5061 CDS An01g00100 4978453 complement(join(24270..24741,24810..25096,25197..25320,25393..25634)) II 1 NT_166518.1 Catalytic activity: Pyruvate + lipoamide = S-acetyldihydrolipoamide + CO(2).; Complex: PDB1 is a component of the multienzyme pyruvate dehydrogenase complex.; Remark: PDB1 has the cofactor thiamin pyrophosphate.; Title: strong similarity to pyruvate dehydrogenase beta chain precursor Pdb1 - Saccharomyces cerevisiae; See PMID 8433986; uncharacterized protein 25634 4978453 An01g00100 Aspergillus niger uncharacterized protein XP_001388462.1 24270 R 5061 CDS An01g00110 4978279 join(26335..26528,26592..27842,27960..28281,28347..28373) II 1 NT_166518.1 Title: strong similarity to hypothetical protein SPAC1039.02 - Schizosaccharomyces pombe; uncharacterized protein 28373 4978279 An01g00110 Aspergillus niger uncharacterized protein XP_059599566.1 26335 D 5061 CDS An01g00120 4978368 complement(join(28504..28537,28614..29636,29720..29949)) II 1 NT_166518.1 Function: MRF1 is suggested to be a transcriptional regulator of genes involved in assembly of mitochondrial respiratory proteins.; Localization: Antibodies against MRF1 detected the antigen localized predominantly in the nucleus in vivo.; Title: similarity to mitochondrial respiratory function protein Mrf1 - Saccharomyces cerevisiae; nucleus; See PMID 8195160; uncharacterized protein 29949 4978368 An01g00120 Aspergillus niger uncharacterized protein XP_001388464.3 28504 R 5061 CDS An01g00130 4977151 join(30454..30592,30664..30988,31065..31240,31314..32188) II 1 NT_166518.1 Function: GatA is involved in the formation of correctly charged Gln-tRNA(Gln) through transamidation of misacylated Glu-tRNA(Gln).; Remark: The three genes, gatC, gatA, and gatB constitute Glu-tRNAGln amidotransferase which is a novel heterotrimeric enzyme required for correct decoding of glutamine codons during translation.; Title: strong similarity to glutamyl-tRNA (Gln) amidotransferase chain A gatA - Bacillus subtilis; See PMID 9342321; uncharacterized protein 32188 4977151 An01g00130 Aspergillus niger uncharacterized protein XP_001388465.1 30454 D 5061 CDS An01g00140 4977056 complement(32574..34196) II 1 NT_166518.1 Remark: Bre2 from S. cerevisiae is a subunit of a complex associated with Set1.; Similarity: Bre2 from S. cerevisiae is a member of the trxG gene super family, some human homologues of which are involved in hematopoiesis and leukemia.; Title: similarity to trithorax related protein Bre2 - Saccharomyces cerevisiae; See PMID 11742990; uncharacterized protein 34196 4977056 An01g00140 Aspergillus niger uncharacterized protein XP_001388466.3 32574 R 5061 CDS An01g00150 4977140 join(35486..35854,35915..36162,36219..37083) II 1 NT_166518.1 Function: ENP1is an essential nuclear protein with effects on N-glycosylation of proteins in the secretory pathway.; Localization: Immunohistochemical studies to define the cellular localization of the ENP1 protein revealed that it was localized to the nucleus.; Title: strong similarity to nuclear protein Enp1 -Saccharomyces cerevisiae; nucleus; See PMID 9034325; uncharacterized protein 37083 4977140 An01g00150 Aspergillus niger uncharacterized protein XP_001388467.1 35486 D 5061 CDS An01g00160 4978432 join(39100..39305,39370..39803,39824..40209) II 1 NT_166518.1 Function: the S. cerevisiae homolog HAC1 encodes the transcription factor that upregulates unfolded protein response (UPR) induced genes.; Pathway: unfolded protein response pathway (UPR).; Remark: an intracellular signaling from the endoplasmic reticulum (ER) to the nucleus, called the unfolded protein response (UPR), is activated when unfolded proteins are accumulated in the ER under a variety of stress conditions ('ER stress').; Remark: expression is controlled by regulated splicing of HAC1 mRNA. regulated mRNA splicing is initiated by Ire1p, and only the product of spliced mRNA is able to induce the response.; Title: similarity to regulator of unfolded protein response (UPR) Hac1 - Saccharomyces cerevisiae; See PMID 7816617; uncharacterized protein 40209 4978432 An01g00160 Aspergillus niger uncharacterized protein XP_059599567.1 39100 D 5061 CDS An01g00170 4978391 join(40931..40975,41097..41687) II 1 NT_166518.1 Remark: RAD52 Inhibitor (Fifty Two Inhibitor).; Title: similarity to hypothetical protein Fti1 -Saccharomyces cerevisiae; See PMID 9159472; uncharacterized protein 41687 4978391 An01g00170 Aspergillus niger uncharacterized protein XP_001388469.1 40931 D 5061 CDS An01g00190 4978375 join(42813..43555,43613..44137,44190..44328,44431..44462,44516..44589,44657..45348) II 1 NT_166518.1 Induction: priB transcript was abundant in primordia, while preprimordial mycelia and mature fruiting bodies contained lower levels of this transcript.; Remark: PRIB binds to the DNA fragment containing the upstream region of priB.; Remark: the PRIB binding site has a length of 16 bp and the consensus sequence 5' GGGGGGGACAGGANCC 3'.; Similarity: the predicted A. niger protein shows similarity to the PRIB protein of L. edodes and similarity to the GAL4 zinc binuclear cluster homology found in many transcription factors.; Title: similarity to protein PRIB - Lentinus edodes; See PMID 9498550; See PMID 8112580; uncharacterized protein 45348 4978375 An01g00190 Aspergillus niger uncharacterized protein XP_059599568.1 42813 D 5061 CDS An01g00200 4978404 join(45640..45672,45864..46212,46278..46464,46521..46822,46875..46954,47010..47041,47112..47229,47296..47517,47601..47735) II 1 NT_166518.1 Catalytic activity: succinyl-coa + a 3-oxo acid = succinate + a 3-oxo-acyl-coa.; Function: key enzyme for ketone body catabolism. transfers the coa moiety from succinate to acetoacetate. formation of the enzyme-coa intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.; Pathway: first step of ketolysis in extrahepatic tissues.; Title: strong similarity to succinyl-CoA:3-ketoacid-CoA transferase SCOT - Homo sapiens; localisation:mitochondrion; See PMID 8751852; uncharacterized protein 47735 4978404 An01g00200 Aspergillus niger uncharacterized protein XP_059599569.1 45640 D 5061 CDS An01g00210 4978439 complement(join(48573..48806,48862..49182,49243..49641,49702..49963,50042..50388)) II 1 NT_166518.1 Title: strong similarity to hypothetical protein AAO27753.1 - Fusarium sporotrichioides; uncharacterized protein 50388 4978439 An01g00210 Aspergillus niger uncharacterized protein XP_001388472.3 48573 R 5061 CDS An01g00220 4978425 complement(join(<51793..52259,52351..52766)) II 1 NT_166518.1 Remark: Protein is probably involved in drug efflux. C-terminus truncated due to end of contig.; Title: strong similarity to hypothetical membrane protein YJR124c - Saccharomyces cerevisiae [truncated ORF]; uncharacterized protein 52766 4978425 An01g00220 Aspergillus niger uncharacterized protein XP_001388473.3 51793 R 5061 CDS An01g00240 4978352 complement(join(55373..56082,56135..56777,56875..56969,57035..57167)) II 1 NT_166518.1 Remark: CYP4F5 showed omega-hydroxylation activity toward leukotriene B4 (LTB4), a chemical mediator of inflammation.; Title: strong similarity to cytochrome P450 protein 4F5 - Rattus norvegicus; See PMID 8554568; See PMID 9344476; uncharacterized protein 57167 4978352 An01g00240 Aspergillus niger uncharacterized protein XP_059603015.1 55373 R 5061 CDS An01g00250 4978440 join(57893..58022,58074..58217,58597..59378) II 1 NT_166518.1 Catalytic activity: NADH + Nitrate = NAD+ + Nitrite + H2O.; Induction: light acts both directly as a signal and indirectly through photosynthesis to regulate the expression of genes encoding nitrate reductase (NR).; Remark: nitrate reductase (NR) is the first enzyme in nitrate assimilation.; Title: strong similarity to nitrate reductase NR2 -Arabidopsis thaliana; See PMID 9014362; See PMID 7991680; uncharacterized protein 59378 4978440 An01g00250 Aspergillus niger uncharacterized protein XP_059603016.1 57893 D 5061 CDS An01g00260 4978456 join(60604..60655,61102..61610,61680..63410) II 1 NT_166518.1 Title: strong similarity to hypothetical transcription activator SPAC139.03 - Schizosaccharomyces pombe; uncharacterized protein 63410 4978456 An01g00260 Aspergillus niger uncharacterized protein XP_059603017.1 60604 D 5061 CDS An01g00270 4978406 join(63949..64311,64387..64791,64862..64979,65038..65292,65346..65686) II 1 NT_166518.1 Remark: putative sequencing error - stop codon at residue 308. The deduced amino acid sequence of FLU1 showed similarity to CaMDR1 (formerly BEN(r)), a member of the major facilitator superfamily of multidrug efflux transporters. The disruption of FLU1 in C. albicans had only a slight effect on fluconazole susceptibility; however, it resulted in hypersusceptibility to mycophenolic acid. Exression of FLU1 in YKKB-13 mediated not only resistance to fluconazole but also to cycloheximide among the different drugs tested.; Title: similarity to fluconazole resistance protein FLU1 - Candida albicans [putative frameshift]; putative frameshift; See PMID 11065353; uncharacterized protein 65686 4978406 An01g00270 Aspergillus niger uncharacterized protein XP_059603018.1 63949 D 5061 CDS An01g00280 4978407 join(67007..67052,67160..67485,67563..67991,68052..68159) II 1 NT_166518.1 Remark: possible phosphatase.; Title: strong similarity to hypothetical protein SPAC823.14 - Schizosaccharomyces pombe; uncharacterized protein 68159 4978407 An01g00280 Aspergillus niger uncharacterized protein XP_001388478.1 67007 D 5061 CDS An01g00290 4978349 join(69017..69642,69702..70065,70123..70533,70815..70824,71023..71162) II 1 NT_166518.1 Title: similarity to hypothetical protein encoded by An17g00430 - Aspergillus niger; uncharacterized protein 71162 4978349 An01g00290 Aspergillus niger uncharacterized protein XP_059603019.1 69017 D 5061 CDS An01g00310 84589813 join(71813..71815,71851..71936,72030..72094,72190..72239,72480..72503,72727..73004,73067..73574) II 1 NT_166518.1 Title: strong similarity to hypothetical protein encoded by An02g10090 - Aspergillus niger; uncharacterized protein 73574 84589813 An01g00310 Aspergillus niger uncharacterized protein XP_059603020.1 71813 D 5061 CDS An01g00320 4978129 complement(join(73906..73954,74092..74876)) II 1 NT_166518.1 Title: similarity to hypothetical protein encoded by An08g08380 - Aspergillus niger; uncharacterized protein 74876 4978129 An01g00320 Aspergillus niger uncharacterized protein XP_001388481.1 73906 R 5061 CDS An01g00330 4978177 join(77956..78099,78152..78666,78715..78798,78847..78923,78972..79004,79056..79207,79258..79746,79802..80194) II 1 NT_166518.1 Catalytic activity: hydrolysis of terminal non-reducing alpha-l-arabinofuranoside residues in alpha-l-arabinosides.; Function: acts only on small linear 1,5-alpha-linked l-arabinofuranosyl oligosaccharide.; Gene-ID: abfA;arfA;awabfA;exoA; Pathway: involved in degradation of the plant cell wall polysaccharide l-arabinan.; See PMID 7764056; See PMID 8000538; alpha-l-arabinofuranosidase a precursor abfA-Aspergillus niger 80194 abfA 4978177 abfA Aspergillus niger alpha-l-arabinofuranosidase a precursor abfA-Aspergillus niger XP_001388482.1 77956 D 5061 CDS An01g00340 4978052 join(81209..81435,81543..82518) II 1 NT_166518.1 Title: strong similarity to hypothetical protein SPCC320.08 - Schizosaccharomyces pombe; uncharacterized protein 82518 4978052 An01g00340 Aspergillus niger uncharacterized protein XP_001388483.1 81209 D 5061 CDS An01g00360 84589814 join(84225..84651,85003..85065,85112..85146,85277..85369) II 1 NT_166518.1 hypothetical protein 85369 84589814 An01g00360 Aspergillus niger hypothetical protein XP_059603021.1 84225 D 5061 CDS An01g00370 4977253 join(87292..87564,87621..88529) II 1 NT_166518.1 Function: aspartic proteinase; hydrolase; hydrolysis of proteins with broad specifity.; Title: strong similarity to aspergillopepsin apnS -Aspergillus phoenicis; See PMID 8142467; uncharacterized protein 88529 4977253 An01g00370 Aspergillus niger uncharacterized protein XP_001388485.3 87292 D 5061 CDS An01g00380 4977459 complement(join(89179..89561,89624..89997,90055..90251)) II 1 NT_166518.1 Function: Lactate transport across cell membranes is mediated by a family of proton-coupled monocarboxylate transporters (MCTs).; Localization: MCT3 of H. sapiens is uniquely expressed in the retinal pigment epithelium.; Title: similarity to monocarboxylate transporter MCT3 - Homo sapiens; See PMID 9425115; See PMID 10493836; See PMID 10510291; uncharacterized protein 90251 4977459 An01g00380 Aspergillus niger uncharacterized protein XP_001388486.1 89179 R 5061 CDS An01g00390 4977603 join(94559..94732,94904..95614) II 1 NT_166518.1 hypothetical protein 95614 4977603 An01g00390 Aspergillus niger hypothetical protein XP_001388487.3 94559 D 5061 CDS An01g00400 4977714 join(98078..98662,98715..98945,98995..99156) II 1 NT_166518.1 Title: strong similarity to hypothetical protein SPBC12C2.09c - Schizosaccharomyces pombe; uncharacterized protein 99156 4977714 An01g00400 Aspergillus niger uncharacterized protein XP_001388488.1 98078 D 5061 CDS An01g00420 84589815 join(100703..100995,101097..101732,101786..101903) II 1 NT_166518.1 Title: strong similarity to hypothetical protein encoded by An01g01580 - Aspergillus niger; uncharacterized protein 101903 84589815 An01g00420 Aspergillus niger uncharacterized protein XP_059603022.1 100703 D 5061 CDS An01g00430 84589816 complement(103009..105537) II 1 NT_166518.1 Function: het-6 of N. crassa is involved in the restriction of heterokaryon formation during asexual growth.; Remark: in filamentous fungi, vegetative cell fusion between genotypically distinct individuals leads to a cell-death reaction known as vegetative or heterokaryon incompatibility.; Similarity: het-6(OR) of N. crassa has three regions of amino acid sequence similarity to the predicted product of the het-e vegetative incompatibility gene in P. anserina and to the predicted product of tol, which mediates mating-type vegetative incompatibility in N. crassa.; Title: similarity to heterokaryon incompatibility protein het-6 - Neurospora crassa; See PMID 10880472; See PMID 11035941; See PMID 11092825; uncharacterized protein 105537 84589816 An01g00430 Aspergillus niger uncharacterized protein XP_059603023.1 103009 R 5061 CDS An01g00450 4978082 complement(join(108997..109124,109636..110458,110520..110564)) II 1 NT_166518.1 Function: mmsB of P. aeruginosa is involved in valine metabolism.; Phenotype: mmsB mutants of P. aeruginosa with insertionally inactivated mmsB grow slowly on valine/isoleucine medium and exhibit reduced enzyme activity in cell-free extracts compared to P. aeruginosa PAO.; Similarity: the ORF shows similarity to various dehydrogenases.; Title: similarity to 3-hydroxyisobutyrate dehydrogenase mmsB - Pseudomonas aeruginosa; uncharacterized protein 110564 4978082 An01g00450 Aspergillus niger uncharacterized protein XP_001388491.3 108997 R 5061 CDS An01g00460 4978303 join(111845..111907,111969..112646) II 1 NT_166518.1 hypothetical protein 112646 4978303 An01g00460 Aspergillus niger hypothetical protein XP_001388492.3 111845 D 5061 CDS An01g00470 84589817 113663..114175 II 1 NT_166518.1 Title: strong similarity to hypothetical protein jhp0584 - Helicobacter pylori; uncharacterized protein 114175 84589817 An01g00470 Aspergillus niger uncharacterized protein XP_059603024.1 113663 D 5061 CDS An01g00480 4978256 114545..117211 II 1 NT_166518.1 Title: strong similarity to hypothetical protein AAO49461.1 - Leptosphaeria maculans; uncharacterized protein 117211 4978256 An01g00480 Aspergillus niger uncharacterized protein XP_001388494.1 114545 D 5061 CDS An01g00490 4977545 join(118609..119069,119144..119628,119688..120292,120342..120776) II 1 NT_166518.1 Title: strong similarity to isoamyl alcohol oxidase mreA - Aspergillus oryzae; uncharacterized protein 120776 4977545 An01g00490 Aspergillus niger uncharacterized protein XP_059603025.1 118609 D 5061 CDS An01g00500 84589818 complement(join(122641..122765,122862..123009)) II 1 NT_166518.1 hypothetical protein 123009 84589818 An01g00500 Aspergillus niger hypothetical protein XP_059603026.1 122641 R 5061 CDS An01g00510 4977082 complement(join(125838..125891,126203..126418,126484..126562,126619..126907,126986..128114)) II 1 NT_166518.1 Catalytic activity: hydroxylation of n-alkanes at the terminal position.; Function: catalyzes the terminal hydroxylation as the first step in the assimilation of alkanes and fatty acids.; Remark: Overproduction of microsomal cytochrome P450Alk1(CYP 52A3) of Candida maltosa in S. cerevisiae resulted in an extensive proliferation of endoplasmic reticulum (ER) and induction of Kar2p and Pdi1p.; Title: strong similarity to cytochrome P450 cyp52A3-a - Candida maltosa; See PMID 8645001; See PMID 10050038; uncharacterized protein 128114 4977082 An01g00510 Aspergillus niger uncharacterized protein XP_059603027.1 125838 R 5061 CDS An01g00520 4977905 complement(join(130637..130751,130945..131021)) II 1 NT_166518.1 hypothetical protein 131021 4977905 An01g00520 Aspergillus niger hypothetical protein XP_059603028.1 130637 R 5061 CDS An01g00530 4977455 complement(133164..134012) II 1 NT_166518.1 Catalytic activity: Preferential cleavage in B chain of insulin: Asn3+Gln, Gly13+Ala,Tyr26+Thr; Gene-ID: proctase-A; Remark: aspergillopepsin II is also called proteinase A or proctase-A. Proteinase A obtained from the culture medium of Aspergillus niger var. macrosporus is a unique acid endopeptidase that is insensitive (or less sensitive) to specific inhibitors of ordinary acid or aspartic proteinases, such as pepstatin,diazoacetyl-DL-norleucine methyl ester,and 1,2-epoxy-3-(p-nitrophenoxy)-propane.; localisation:extracellular/secretion proteins; similarity: belongs to peptidase family a4.; See PMID 9561230; See PMID 9561240; See PMID 1918059; See PMID 1918060; proteinase aspergillopepsin II-Aspergillus niger 134012 proctase-A 4977455 proctase-A Aspergillus niger proteinase aspergillopepsin II-Aspergillus niger XP_001388499.1 133164 R 5061 CDS An01g00540 84589819 join(135495..135552,135602..135618,135997..136184,136473..136508,136662..136740) II 1 NT_166518.1 hypothetical protein 136740 84589819 An01g00540 Aspergillus niger hypothetical protein XP_059603029.1 135495 D 5061 CDS An01g00550 4977122 complement(138081..138920) II 1 NT_166518.1 Function: rAsp f 4 of A. fumigatus expressed on the surface of the filamentous phage M13 is an allergen, which is bound by human serum IgE.; Title: strong similarity to allergen rAsp f 4 -Aspergillus fumigatus; uncharacterized protein 138920 4977122 An01g00550 Aspergillus niger uncharacterized protein XP_001388501.1 138081 R 5061 CDS An01g00560 4978133 complement(join(141666..141888,141971..142179)) II 1 NT_166518.1 Function: Sec11 from S. cerevisiae is a subunit of the microsomal signal peptidase, a complex of four polypeptides.; Function: Sec11 from S. cerevisiae is required for signal peptide cleavage, signal peptidase-dependent protein degradation, and yeast cell growth.; Title: strong similarity to signal peptidase subunit Sec11 - Saccharomyces cerevisiae; localisation:endoplasmatic reticulum; See PMID 9148930; See PMID 1846444; See PMID 3283143; uncharacterized protein 142179 4978133 An01g00560 Aspergillus niger uncharacterized protein XP_001388502.3 141666 R 5061 CDS An01g00570 4978496 complement(142634..143836) II 1 NT_166518.1 Title: weak similarity to hypothetical protein -Campylobacter jejuni; uncharacterized protein 143836 4978496 An01g00570 Aspergillus niger uncharacterized protein XP_001388503.1 142634 R 5061 CDS An01g00600 10098204 join(145907..146423,146563..146636,146849..146994,147053..148366,148508..148733) II 1 NT_166518.1 Remark: putative reductase; Title: similarity to hypothetical protein YLR011w -Saccharomyces cerevisiae; uncharacterized protein 148733 10098204 An01g00600 Aspergillus niger uncharacterized protein XP_003188545.2 145907 D 5061 CDS An01g00610 4978421 join(149971..150650,150735..150783) II 1 NT_166518.1 Title: strong similarity to hypothetical protein BAC69773.1 - Streptomyces avermitilis; uncharacterized protein 150783 4978421 An01g00610 Aspergillus niger uncharacterized protein XP_001388505.3 149971 D 5061 CDS An01g00620 4977698 complement(join(150927..151559,151615..152385,152456..152485)) II 1 NT_166518.1 Function: converts p-cumic aldehyde + H20 + NAD to p-cumate + NADH; Remark: Pseudomonas putida F1 utilizes p-cymene (p-isopropyltoluene) by an 11-step pathway through p-cumate (p-isopropylbenzoate) to isobutyrate, pyruvate, and acetyl coenzyme A.; Title: strong similarity to p-cumic aldehyde dehydrogenase cymc - Pseudomonas putida; See PMID 8631713; See PMID 9150211; uncharacterized protein 152485 4977698 An01g00620 Aspergillus niger uncharacterized protein XP_059603030.1 150927 R 5061 CDS An01g00630 4977807 join(153643..153835,153885..154657,154710..154856) II 1 NT_166518.1 Remark: Acinetobacter sp. strain ADP1 is able to grow on a range of esters of aromatic alcohols, converting them to the corresponding aromatic carboxylic acids by the sequential action of three inducible enzymes: an areA-encoded esterase, an areB-encoded benzyl alcohol dehydrogenase, and an areC-encoded benzaldehyde dehydrogenase.; Title: strong similarity to benzyl alcohol dehydrogenase areB - Acinetobacter sp.; See PMID 10419955; uncharacterized protein 154856 4977807 An01g00630 Aspergillus niger uncharacterized protein XP_059603031.1 153643 D 5061 CDS An01g00640 4978092 complement(join(155185..155996,156073..156220,156282..157010)) II 1 NT_166518.1 Title: strong similarity to hypothetical protein CAD21096.1 - Neurospora crassa; uncharacterized protein 157010 4978092 An01g00640 Aspergillus niger uncharacterized protein XP_001388508.3 155185 R 5061 CDS An01g00650 84589820 complement(157927..158202) II 1 NT_166518.1 hypothetical protein 158202 84589820 An01g00650 Aspergillus niger hypothetical protein XP_059603032.1 157927 R 5061 CDS An01g00660 4978380 join(159669..160056,160111..160430,160569..160748,160813..160857) II 1 NT_166518.1 Title: similarity to hypothetical protein rfeF -Aspergillus nidulans; uncharacterized protein 160857 4978380 An01g00660 Aspergillus niger uncharacterized protein XP_059599544.1 159669 D 5061 CDS An01g00670 84589821 join(161149..161157,161391..161474,161717..161777,161899..162186,162242..162602,162660..162783,162836..163143,163229..163361) II 1 NT_166518.1 hypothetical protein 163361 84589821 An01g00670 Aspergillus niger hypothetical protein XP_059599545.1 161149 D 5061 CDS An01g00680 4977405 join(164378..164425,164478..165590,165653..165985) II 1 NT_166518.1 Catalytic activity: Benzoate + NADPH + O2 = 4-Hydroxybenzoate + NADP+ + H2O.; Similarity: avnA of Aspergillus parasiticus is involved in aflatoxin biosynthetic pathway; Title: strong similarity to cytochrome P450 monooxygenase avnA - Aspergillus parasiticus; See PMID 9097431; uncharacterized protein 165985 4977405 An01g00680 Aspergillus niger uncharacterized protein XP_001388512.1 164378 D 5061 CDS An01g00690 4978446 complement(166755..167882) II 1 NT_166518.1 Title: strong similarity to FLO11 gene expression regulator At14 from patent WO200257456-A2 - Unclassified organism; uncharacterized protein 167882 4978446 An01g00690 Aspergillus niger uncharacterized protein XP_001388513.1 166755 R 5061 CDS An01g00700 4978084 join(168522..168687,168766..169002,169073..169518) II 1 NT_166518.1 Remark: Overexpression of RTM1 confers resistance to the toxicity of molasses. The RTM1 gene encodes a hydrophobic 34-kD protein that contains seven potential transmembrane-spanning segments.; Title: strong similarity to molasses resistency protein Rtm1 - Saccharomyces cerevisiae; See PMID 7672593; uncharacterized protein 169518 4978084 An01g00700 Aspergillus niger uncharacterized protein XP_059599546.1 168522 D 5061 CDS An01g00710 4977531 complement(169885..171300) II 1 NT_166518.1 Function: aromatic-L-amino-acid decarboxylases catalyses the decarboxylation of tryptophan to tryptamine.; Function: ddc of Sorangium cellulosum is converting L-dopa (dihydroxy- L-phenylalanine) to dopamine.; Remark: the predicted ORF is a probable pyridoxal-dependent decarboxylase family member.; Similarity: the ORF shows similarity to pyridoxal phosphate-dependent carboxylases involved in the decarboxylation of aromatic amino acids, which in some cases leads to the synthesis of alkaloids/eucaryotic neurotransmitters like dopamine.; Title: strong similarity to aromatic amino acid decarboxylase ddc - Sorangium cellulosum; See PMID 10816050; uncharacterized protein 171300 4977531 An01g00710 Aspergillus niger uncharacterized protein XP_001388515.1 169885 R 5061 CDS An01g00720 4978169 join(173504..173725,173778..173861,173915..173990,174042..174106,174176..174280,174330..174423,174470..174795,174844..174901,174949..175042,175096..175283,175337..175396,175446..175807) II 1 NT_166518.1 Function: sit1 of S. cerevisiae is a ferrioxamine B permease involved in siderophore (microbial iron chelators) iron transport.; Phenotype: S. cerevisiae cells with a deleted sit1 gene are unable to take up ferrioxamine B.; Remark: sit1 of S. cerevisiae is also called ARN3 or YEL065W.; Similarity: the ORF shows similarity to several major facilitator protein homologs from different species and with various specificities.; Title: strong similarity to transporter sit1 -Saccharomyces cerevisiae; See PMID 10816729; uncharacterized protein 175807 4978169 An01g00720 Aspergillus niger uncharacterized protein XP_001388516.1 173504 D 5061 CDS An01g00730 4977066 join(176385..176699,176770..177487,177565..177739,177828..178146,178206..178524,178654..179353,179406..179619,179689..179952,180022..180219,180278..>180823) II 1 NT_166518.1 Remark: the ORF is truncated due to the contig border.; hypothetical protein [truncated ORF] 180823 4977066 An01g00730 Aspergillus niger hypothetical protein [truncated ORF] XP_059599547.1 176385 D 5061 CDS An01g00740 84589822 <180928..181542 II 1 NT_166518.1 Remark: N-terminally truncated due to contig border.; hypothetical protein [truncated ORF] 181542 84589822 An01g00740 Aspergillus niger hypothetical protein [truncated ORF] XP_059603033.1 180928 D 5061 CDS An01g00750 4977944 join(184131..184357,184426..184444) II 1 NT_166518.1 hypothetical protein 184444 4977944 An01g00750 Aspergillus niger hypothetical protein XP_001388519.1 184131 D 5061 CDS An01g00760 84589823 complement(186071..186286) II 1 NT_166518.1 hypothetical protein 186286 84589823 An01g00760 Aspergillus niger hypothetical protein XP_059603034.1 186071 R 5061 CDS An01g00770 4977762 complement(187506..189152) II 1 NT_166518.1 Function: pMSS116 promotes ATP-dependent splicing of group II introns in yeast.; Localization: pMSS116 is localized in the mitochondrial matrix.; Similarity: pMSS116 has DEAD/H box RNA helicase homology.; Title: similarity to RNA helicase Mss116 -Saccharomyces cerevisiae; See PMID 2535893; See PMID 7567443; uncharacterized protein 189152 4977762 An01g00770 Aspergillus niger uncharacterized protein XP_001388521.1 187506 R 5061 CDS An01g00780 4978152 complement(join(190078..190477,190546..190823)) II 1 NT_166518.1 Catalytic activity: Endohydrolysis of 1,4-beta-d-xylosidic linkages in xylans.; Gene-ID: xynB; Pathway: Xylan degradation.; Similarity: Belongs to cellulase family g (family 11 of glycosyl hydrolases).; endo-1,4-xylanase xynB-Aspergillus niger 190823 xynB 4978152 xynB Aspergillus niger endo-1,4-xylanase xynB-Aspergillus niger XP_001388522.1 190078 R 5061 CDS An01g00790 84589824 complement(join(191427..191494,191549..191690)) II 1 NT_166518.1 hypothetical protein 191690 84589824 An01g00790 Aspergillus niger hypothetical protein XP_059603035.1 191427 R 5061 CDS An01g00800 4978098 complement(join(191853..191935,192004..192844)) II 1 NT_166518.1 Title: similarity to hypothetical protein AAO51454.1 - Dictyostelium discoideum; uncharacterized protein 192844 4978098 An01g00800 Aspergillus niger uncharacterized protein XP_001388524.1 191853 R 5061 CDS An01g00810 84589825 complement(join(193759..193792,193845..194194)) II 1 NT_166518.1 Title: weak similarity to androgen receptor A hARa -Homo sapiens; uncharacterized protein 194194 84589825 An01g00810 Aspergillus niger uncharacterized protein XP_059603036.1 193759 R 5061 CDS An01g00820 4978462 join(195689..195765,195827..196269,196332..196969,197025..197459) II 1 NT_166518.1 Function: The QUTD gene encodes an essential component of a permease required for transport of quinate ion into mycelium.; Localization: The QUTD gene has been located within the cloned QUT gene cluster of A. nidulans.; Similarity: The QutD gene shows strong homology with the N. crassa QA-Y gene.; Title: strong similarity to quinate transport protein qutD - Aspergillus nidulans; See PMID 2835177; See PMID 2976880; uncharacterized protein 197459 4978462 An01g00820 Aspergillus niger uncharacterized protein XP_059603037.1 195689 D 5061 CDS An01g00830 84589826 complement(join(197782..197850,197901..198002)) II 1 NT_166518.1 hypothetical protein 198002 84589826 An01g00830 Aspergillus niger hypothetical protein XP_059603038.1 197782 R 5061 CDS An01g00840 84589827 complement(join(198877..198957,199120..199346,199437..199526,199605..199739,199832..199925)) II 1 NT_166518.1 hypothetical protein 199925 84589827 An01g00840 Aspergillus niger hypothetical protein XP_059603039.1 198877 R 5061 CDS An01g00850 4978119 join(199947..200369,200419..200533,200628..201020,201084..201437,201508..201911) II 1 NT_166518.1 Function: Xylose uptake in Bacillus megaterium depends on expression of a H+/xylose symporter encoded by xylT, the last gene in the xyl operon.; Remark: Expression of xylT is xylose inducible.; Title: similarity to xylose permease xylT - Bacillus megaterium; See PMID 9076741; uncharacterized protein 201911 4978119 An01g00850 Aspergillus niger uncharacterized protein XP_059603040.1 199947 D 5061 CDS An01g00860 4977875 complement(join(<202342..204060,204119..204197)) II 1 NT_166518.1 Catalytic activity: DHGO is an enzyme catalyzing the stereospecific phenol oxidative coupling reaction converting dihydrogeodin to (+)- geodin.; Remark: a putative frameshift results in an premature STOP codon.; Similarity: DHGO shows significant homology with multicopper blue proteins such as laccase and ascorbate oxidase.; Title: strong similarity to dihydrogeodin oxidase DHGO - Aspergillus terreus [putative frameshift]; putative frameshift; See PMID 7665560; uncharacterized protein 204197 4977875 An01g00860 Aspergillus niger uncharacterized protein XP_059603041.1 202342 R 5061 CDS An01g00870 4978100 complement(205013..206032) II 1 NT_166518.1 Catalytic activity: COQ2 catalyzes the transfer of the polyisoprenoid side chain to para-hydroxybenzoate (PHB).; Pathway: COQ2 catalyzes a step in the biosynthesis of the lipid-soluble electron carrier Coenzyme Q.; Remark: The amino acid sequence of COQ2 exhibits a typical amino-terminal mitochondrial leader sequence and six potential membrane-spanning domains.; Title: strong similarity to para-hydroxybenzoate polyprenyltransferase Coq2 - Saccharomyces cerevisiae; See PMID 1740455; uncharacterized protein 206032 4978100 An01g00870 Aspergillus niger uncharacterized protein XP_001388531.1 205013 R 5061 CDS An01g00880 4978490 complement(join(207172..207485,207541..207980,208048..208171,208226..208352,208411..208551)) II 1 NT_166518.1 Catalytic activity: 6-OMT catalyzes the transfer of the S-methyl group of S-adenosyl-L-methionine to the 6-hydroxyl group of 1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-6,7-isoquin olinediol (norcoclaurine).; Pathway: 6-OMT catalyzes an early step in the biosynthetic pathway to reticuline, an important intermediate in synthesizing isoquinoline alkaloids.; Title: strong similarity to S-adenosyl-L-methionine:norcoclaurine 6-O-methyltransferase 6-OMT - Coptis japonica; See PMID 7925429; See PMID 10811648; uncharacterized protein 208551 4978490 An01g00880 Aspergillus niger uncharacterized protein XP_001388532.1 207172 R 5061 CDS An01g00890 4978419 join(209578..209742,209813..210188,210254..210383,210446..210513,210584..210918) II 1 NT_166518.1 Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea; uncharacterized protein 210918 4978419 An01g00890 Aspergillus niger uncharacterized protein XP_001388533.1 209578 D 5061 CDS An01g00900 4978437 complement(join(211858..212390,212757..212916,213021..213286,213407..213603,213662..213682,213731..214432,214486..215176,215239..215482)) II 1 NT_166518.1 Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.; Function: pyp2+ encodes a nonreceptor type protein tyrosine phosphatase that negatively regulates mitosis.; Title: similarity to protein-tyrosine-phosphatase pyp2p - Schizosaccharomyces pombe; See PMID 1448087; See PMID 1464319; uncharacterized protein 215482 4978437 An01g00900 Aspergillus niger uncharacterized protein XP_059603042.1 211858 R 5061 CDS An01g00910 4978500 join(215818..216653,216705..218738,218821..218884,219155..219220) II 1 NT_166518.1 Title: strong similarity to hypothetical protein CAD21096.1 - Neurospora crassa; uncharacterized protein 219220 4978500 An01g00910 Aspergillus niger uncharacterized protein XP_059603043.1 215818 D 5061 CDS An01g00920 84589828 219994..220749 II 1 NT_166518.1 Title: strong similarity to hypothetical lysogenic protein CAD54907.1 - Bacteriophage P2-EC58; uncharacterized protein 220749 84589828 An01g00920 Aspergillus niger uncharacterized protein XP_059603044.1 219994 D 5061 CDS An01g00930 4978351 join(222156..222638,222773..223132) II 1 NT_166518.1 Catalytic activity: Methyl chloride transferase catalyzes the synthesis of methyl chloride from S-adenosine-L-methionine and chloride ion.; Title: similarity to methyl chloride transferase AAC72357.1 - Batis maritima; See PMID 9789006; uncharacterized protein 223132 4978351 An01g00930 Aspergillus niger uncharacterized protein XP_001388537.1 222156 D 5061 CDS An01g00940 4977581 complement(join(223396..223562,223630..224770)) II 1 NT_166518.1 Title: weak similarity to AP-1-like stress-induced transcriptional activator Yap2 - Saccharomyces cerevisiae; uncharacterized protein 224770 4977581 An01g00940 Aspergillus niger uncharacterized protein XP_001388538.3 223396 R 5061 CDS An01g00950 4978463 join(225110..225206,225260..225555,225688..225707,225755..225893,226089..226097,226147..226229,226267..226294,226561..226609,226881..227009,227172..227545) II 1 NT_166518.1 Title: weak similarity to hypothetical protein encoded by An11g07790 - Aspergillus niger; uncharacterized protein 227545 4978463 An01g00950 Aspergillus niger uncharacterized protein XP_001388539.3 225110 D 5061 CDS An01g00960 4978427 complement(227971..228969) II 1 NT_166518.1 Title: strong similarity to hypothetical oxidoreductase DR2595 - Deinococcus radiodurans; uncharacterized protein 228969 4978427 An01g00960 Aspergillus niger uncharacterized protein XP_001388540.1 227971 R 5061 CDS An01g00970 84589829 join(229718..230116,230174..230217,230694..230836,231079..231392) II 1 NT_166518.1 Title: similarity to hypothetical protein encoded by An11g04000 - Aspergillus niger; uncharacterized protein 231392 84589829 An01g00970 Aspergillus niger uncharacterized protein XP_059603045.1 229718 D 5061 CDS An01g00990 84589830 complement(233314..233586) II 1 NT_166518.1 Title: weak similarity to hypothetical protein encoded by An01g12970 - Aspergillus niger; uncharacterized protein 233586 84589830 An01g00990 Aspergillus niger uncharacterized protein XP_059603046.1 233314 R 5061 CDS An01g01000 4977449 complement(join(233771..234620,234656..234834,234891..235094)) II 1 NT_166518.1 Title: similarity to hypothetical protein BAC11036.1 - Homo sapiens; uncharacterized protein 235094 4977449 An01g01000 Aspergillus niger uncharacterized protein XP_059603047.1 233771 R 5061 CDS An01g01010 4977123 complement(235716..236969) II 1 NT_166518.1 Title: weak similarity to hypothetical protein Y49E10.24 - Caenorhabditis elegans; uncharacterized protein 236969 4977123 An01g01010 Aspergillus niger uncharacterized protein XP_001388544.1 235716 R 5061 CDS An01g01020 4978227 join(238713..238872,238928..242046) II 1 NT_166518.1 Title: similarity to protein SEQ ID NO:628 from patent WO200222660-A2 - Homo sapiens; uncharacterized protein 242046 4978227 An01g01020 Aspergillus niger uncharacterized protein XP_059603048.1 238713 D 5061 CDS An01g01030 4977640 complement(242490..242972) II 1 NT_166518.1 Title: weak similarity to hypothetical protein encoded by An16g05360 - Aspergillus niger; uncharacterized protein 242972 4977640 An01g01030 Aspergillus niger uncharacterized protein XP_001388546.1 242490 R 5061 CDS An01g01040 84589831 243525..245264 II 1 NT_166518.1 Function: Ank3 plays an important role in the polarized distribution of many integral membrane proteins.; Function: the ankyrin domain is supposed to mediate protein-protein interactions.; Localization: Ank3 is a broadly distributed epithelial ankyrin and is the major ankyrin in the kidney and other tissues.; Remark: Ank3 is expressed in alternatively spliced forms including forms that lack the NH2-terminal repeat domain.; Title: similarity to ankyrin 3 Ank3 - Mus musculus; See PMID 7615634; See PMID 9060470; uncharacterized protein 245264 84589831 An01g01040 Aspergillus niger uncharacterized protein XP_059603049.1 243525 D 5061 CDS An01g01050 4978267 complement(join(246521..246814,246879..247483,247543..247675)) II 1 NT_166518.1 Title: similarity to hypothetical protein YLR007w -Saccharomyces cerevisiae; uncharacterized protein 247675 4978267 An01g01050 Aspergillus niger uncharacterized protein XP_001388548.1 246521 R 5061 CDS An01g01060 4977558 complement(join(248200..248528,248608..248908)) II 1 NT_166518.1 Complex: Forms a heterodimer with the spU2AF59 large subunit.; Function: spU2AF23 is the SNRNP auxiliary factor small subunit which is necessary for the splicing of pre-mRNA.; Localization: Nuclear protein.; Remark: Binds to the polypyrimidine tract of introns early during spliceosome assembly.; Title: strong similarity to splicing factor spU2AF23 - Schizosaccharomyces pombe; See PMID 8657565; uncharacterized protein 248908 4977558 An01g01060 Aspergillus niger uncharacterized protein XP_001388549.1 248200 R 5061 CDS An01g01070 4978091 complement(join(249120..249205,249343..250169,250223..250677)) II 1 NT_166518.1 Title: strong similarity to hypothetical protein BAB09014.1 - Arabidopsis thaliana; uncharacterized protein 250677 4978091 An01g01070 Aspergillus niger uncharacterized protein XP_059603050.1 249120 R 5061 CDS An01g01080 4978236 join(252231..252267,252348..252661,252752..253122,253180..253216) II 1 NT_166518.1 Catalytic activity: 7,8-dihydrobiopterin + NADP(+) = sepiapterin + NADPH.; Pathway: Sepiapterin reductase SPR (7,8-dihydrobiopterin: NADP+ oxidoreductase) catalyzes the terminal step in the biosynthetic pathway for tetrahydrobiopterin, the cofactor necessary for aromatic amino acid hydroxylation.; Title: strong similarity to sepiapterin reductase SPR - Rattus norvegicus; See PMID 2201030; See PMID 2260974; uncharacterized protein 253216 4978236 An01g01080 Aspergillus niger uncharacterized protein XP_001388551.1 252231 D 5061 CDS An01g01090 4977927 join(254023..254044,254113..254139,254292..254551,254617..254736) II 1 NT_166518.1 Complex: Dr1 directly interacts with the TATA-binding protein (TBP) subunit of the multiprotein TFIID complex.; Function: Dr1 has a regulatory role in repression of class II gene transcription that is mediated via phosphorylation.; Title: similarity to TATA-binding protein-associated phosphoprotein Dr1 - Homo sapiens; See PMID 7958881; See PMID 1339312; uncharacterized protein 254736 4977927 An01g01090 Aspergillus niger uncharacterized protein XP_001388552.1 254023 D 5061 CDS An01g01110 4978156 complement(join(256770..259709,259823..260389)) II 1 NT_166518.1 Function: Pseudomonas sp. hyuA is involved in the conversion of D-5-substituted hydantoins to corresponding N-carbamyl-D-amino acids.; Title: strong similarity to D-amino acid hydantoin hydrolase hyuA - Pseudomonas sp.; See PMID 1732229; uncharacterized protein 260389 4978156 An01g01110 Aspergillus niger uncharacterized protein XP_059603051.1 256770 R 5061 CDS An01g01120 84589832 join(261196..261315,261384..261485,262180..262531,262624..262700,263299..263306,263456..263514,263593..263747,263784..263827,263913..264025,264243..265241,265631..265686,265748..265863,265941..265965) II 1 NT_166518.1 Title: similarity to hypothetical protein encoded by An11g03480 - Aspergillus niger; uncharacterized protein 265965 84589832 An01g01120 Aspergillus niger uncharacterized protein XP_059603052.1 261196 D 5061 CDS An01g01130 4978278 complement(join(266481..266527,266944..266979,267081..273424,273498..273834,273895..274227,274300..274393)) II 1 NT_166518.1 Function: G. fujikuroi FUM5 is a polyketide synthase required for fumonisin-toxin biosynthesis.; Title: strong similarity to polyketide synthase FUM5 - Gibberella moniliformis; See PMID 10413619; uncharacterized protein 274393 4978278 An01g01130 Aspergillus niger uncharacterized protein XP_001388555.3 266481 R 5061 CDS An01g01140 4977989 complement(276183..277523) II 1 NT_166518.1 Title: strong similarity to hypothetical protein encoded by An01g12050 - Aspergillus niger; uncharacterized protein 277523 4977989 An01g01140 Aspergillus niger uncharacterized protein XP_001388556.1 276183 R 5061 CDS An01g01150 4978094 join(277784..277994,278016..278299,278362..279267,279665..279802) II 1 NT_166518.1 Function: M. grisea Pth11p can activate appressorium differentiation in response to inductive surface cues and repress differentiation on poorly inductive surfaces using multiple signaling pathways to mediate differentiation.; Remark: the adjacent genomic region contains another predicted A. niger protein with similarity to M. grisea PTH11.; Similarity: similarity is from the N-terminal region of the predicted A. niger protein to the N-terminal region of M. grisea PTH11, which is 100 aa longer.; Title: similarity to surface recognition protein PTH11 - Magnaporthe grisea; localisation:plasma membrane; See PMID 10521529; uncharacterized protein 279802 4978094 An01g01150 Aspergillus niger uncharacterized protein XP_001388557.3 277784 D 5061 CDS An01g01160 4977050 280500..281690 II 1 NT_166518.1 Function: S. viridochromogenes pat is involved in the metabolism of the herbicide glufosinate and can confer resistance against glufosinate.; Similarity: similarity is from the C-terminal region of the predicted A. niger protein to S. viridochromogenes pat, which is 100 aa shorter.; Title: similarity to phosphinothricin N-acetyltransferase pat - Streptomyces viridochromogenes; See PMID 3240868; uncharacterized protein 281690 4977050 An01g01160 Aspergillus niger uncharacterized protein XP_001388558.3 280500 D 5061 CDS An01g01170 4978135 283362..284579 II 1 NT_166518.1 Title: strong similarity to hypothetical protein BAC47708.1 - Bradyrhizobium japonicum; uncharacterized protein 284579 4978135 An01g01170 Aspergillus niger uncharacterized protein XP_001388559.1 283362 D 5061 CDS An01g01180 4977730 complement(join(285933..286156,286188..286565,286625..287301,287428..287600)) II 1 NT_166518.1 Similarity: the C-terminal region of the predicted A. niger protein contains a chromate transporter motif.; Title: strong similarity to hypothetical conserved protein CAD21291.1 - Neurospora crassa; uncharacterized protein 287600 4977730 An01g01180 Aspergillus niger uncharacterized protein XP_059603053.1 285933 R 5061 CDS An01g01190 4977665 288459..289091 II 1 NT_166518.1 Similarity: the predicted A. niger protein contains a phosphoglycerate mutase motif.; Title: similarity to hypothetical phosphoglycerate mutase SPAC5H10.03 - Schizosaccharomyces pombe; uncharacterized protein 289091 4977665 An01g01190 Aspergillus niger uncharacterized protein XP_001388561.1 288459 D 5061 CDS An01g01210 84589833 complement(join(289556..291127,291186..291551)) II 1 NT_166518.1 Function: R. norvegicus acyl-peptide hydrolase is a serine protease which catalyzes the removal of an N alpha-acetylated amino acid residue from an N alpha-acetylated peptide.; Similarity: the predicted A. niger protein shows strong similarity to several putative mikrobial acyl-peptide hydrolases.; Title: similarity to acylaminoacyl-peptidase -Rattus norvegicus; See PMID 2722805; uncharacterized protein 291551 84589833 An01g01210 Aspergillus niger uncharacterized protein XP_059603054.1 289556 R 5061 CDS An01g01220 4977163 complement(join(292065..292554,292646..293037,293094..293234,293299..293460)) II 1 NT_166518.1 Function: M. grisea Pth11p can activate appressorium differentiation in response to inductive surface cues and repress differentiation on poorly inductive surfaces using multiple signaling pathways to mediate differentiation.; Remark: the adjacent genomic region contains another predicted A. niger protein with similarity to M. grisea PTH11.; Similarity: similarity is from the N-terminal region of the predicted A. niger protein to the N-terminal region of M. grisea PTH11, which is 200 aa longer.; Title: similarity to surface recognition protein PTH11 - Magnaporthe grisea; localisation:plasma membrane; See PMID 10521529; uncharacterized protein 293460 4977163 An01g01220 Aspergillus niger uncharacterized protein XP_059603055.1 292065 R 5061 CDS An01g01230 4977518 join(295236..295568,295622..295966) II 1 NT_166518.1 Title: strong similarity to hypothetical protein SPAC869.06c - Schizosaccharomyces pombe; uncharacterized protein 295966 4977518 An01g01230 Aspergillus niger uncharacterized protein XP_001388564.1 295236 D 5061 CDS An01g01240 84589834 complement(296229..>296786) II 1 NT_166518.1 Function: C. carbonum TOXA likely encodes an HC-toxin efflux pump which contributes to self-protection against HC-toxin and/or the secretion of HC-toxin into the extracellular milieu.; Remark: ORF 5'truncated due to end of contig.; Remark: the function of C. carbonum TOXA is indicated by its sequence similarity to the major facilitator superfamily and the impossibility to mutate TOXA in HC-toxin producing strains.; Similarity: C. carbonum TOXA is a member of the major facilitator superfamily.; Title: similarity to HC-toxin efflux pump TOXA -Cochliobolus carbonum [truncated ORF]; localisation:plasma membrane; See PMID 8704997; uncharacterized protein 296786 84589834 An01g01240 Aspergillus niger uncharacterized protein XP_059603056.1 296229 R 5061 CDS An01g01250 10098206 complement(join(<296889..297292,297350..297782,297834..297863,297930..298115)) II 1 NT_166518.1 Remark: the ORF is C-terminally truncated due to end of contig.; Similarity: belongs to the major falicitator superfamily (MFS).; Title: strong similarity to hypothetical membrane transport protein SPAC3H1.06c - Schizosaccharomyces pombe [truncated ORF]; 298115 10098206 An01g01250 Aspergillus niger 296889 R 5061 CDS An01g01260 4978051 complement(299013..300797) II 1 NT_166518.1 Catalytic activity: beta-D-glucuronoside + H2O = D-glucuronate + alcohol.; Function: beta-glucuronidase of E. coli is widely used as a gene expression reporter in transgenic organisms.; Repression: expression of uidA in E. coli is negatively controlled by the products of the uidR and uxuR genes and is sensitive to catabolite repression.; Title: strong similarity to beta-glucuronidase uidA - Escherichia coli; See PMID 1323505; See PMID 2504501; See PMID 2823062; uncharacterized protein 300797 4978051 An01g01260 Aspergillus niger uncharacterized protein XP_001388566.1 299013 R 5061 CDS An01g01270 84589835 join(302329..302431,302714..302871) II 1 NT_166518.1 Remark: the ORF is short in length (86 amino acids) and has an unusual exon/intron structure for A. niger.; Title: questionable ORF; uncharacterized protein 302871 84589835 An01g01270 Aspergillus niger uncharacterized protein XP_059599564.1 302329 D 5061 CDS An01g01280 4977027 complement(304266..305921) II 1 NT_166518.1 Function: expression of the membrane pump protein of patent W35808 regulates cercosporin production and pathogenicity of C. kikuchii.; Function: the membrane protein pump of patent W35808 confers resistance to the polyketide phytotoxin cercosporin.; Similarity: also shows strong similarity to hypothetical HC-toxin efflux pump TOXA of Cochliobolus carbonum (PubMed 8704997).; Similarity: belongs to the major facilitator superfamily of transmembrane transport proteins.; Similarity: shows strong similarity to protein patent database entry GENESEQPROT:W35808.; Title: strong similarity to cercosporin resistance transmembrane efflux pump from patent WO9735001-A1 -Cercospora kikuchii; uncharacterized protein 305921 4977027 An01g01280 Aspergillus niger uncharacterized protein XP_001388568.1 304266 R 5061 CDS An01g01290 4978037 join(307727..309162,309193..309838) II 1 NT_166518.1 Catalytic activity: SHC in A. acidocaldarius catalyzes the cyclization of squalene into hopene.; Pathway: SHC in A. acidocaldarius is the key enzyme in the synthesis of pentacyclic hopanoids (triterpenoids).; Similarity: also shows strong similarity to lanosterol synthase (EC 5. 4. 99. 7) of Alicyclobacillus acidoterrestris.; Similarity: belongs to the terpene cyclase/mutase family.; Title: strong similarity to squalene-hopene cyclase SHC - Alicyclobacillus acidocaldarius; localisation:plasma membrane; See PMID 9295270; See PMID 1729216; uncharacterized protein 309838 4978037 An01g01290 Aspergillus niger uncharacterized protein XP_059603057.1 307727 D 5061 CDS An01g01300 84589836 complement(join(309947..310232,310346..310397,310784..310988)) II 1 NT_166518.1 hypothetical protein 310988 84589836 An01g01300 Aspergillus niger hypothetical protein XP_059603058.1 309947 R 5061 CDS An01g01310 4977577 complement(join(311419..311610,311706..311804,311854..311953,312007..312317)) II 1 NT_166518.1 hypothetical protein 312317 4977577 An01g01310 Aspergillus niger hypothetical protein XP_059603059.1 311419 R 5061 CDS An01g01320 4978099 join(312690..313296,313361..313457,313509..313924,313993..313997,314070..314120) II 1 NT_166518.1 Catalytic activity: Asp 130 within the conserved YLKYDNC motif is the catalytic nucleophile in the active site of agal in P. chrysosporium.; Catalytic activity: alpha-galactosidases catalyze the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides.; Function: alpha-galactosidase of C. tetragonoloba is involved in the hydrolysis of galactomannans and melibiose.; Similarity: also shows strong similarity to alpha-galactosidase from Cyamopsis tetragonoloba (guar) of protein patent GENESEQPROT:R70206.; Similarity: belongs to family 27 of glycosyl hydrolases.; Similarity: contains the YLKYDNC motif which is highly conserved in all known family 27 glycosyl hydrolases.; Title: strong similarity to alpha-galactosidase agal - Phanerochaete chrysosporium; See PMID 10933800; See PMID 2577496; uncharacterized protein 314120 4978099 An01g01320 Aspergillus niger uncharacterized protein XP_059603060.1 312690 D 5061 CDS An01g01330 4978215 join(314474..314546,314593..314644,314786..314841,315138..315295,315362..316360,316422..316981,317039..317832,317933..317976) II 1 NT_166518.1 Function: FacB of E. nidulans is a hypothetical DNA-binding transcriptional activator involved in the regulation of acetamide and acetate utilisation.; Similarity: the ORF shows similarity to several transcription activators.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; See PMID 9197408; uncharacterized protein 317976 4978215 An01g01330 Aspergillus niger uncharacterized protein XP_059603061.1 314474 D 5061 CDS An01g01340 4978230 complement(join(318138..319409,319474..319617)) II 1 NT_166518.1 Function: UGL of Bacillus sp. GL1 hydrolyzes the tetrasaccharide of unsaturated glucuronyl-glucosyl-rhamnosyl-glucose releasing unsaturated glucuronate.; Pathway: UGL of Bacillus sp. GL1 is involved in the degradation of oligosaccharides with an unsaturated uronic acid at the nonreducing terminal produced by polysaccharide lyases.; Title: similarity to unsaturated glucuronyl hydrolase UGL - Bacillus sp.; See PMID 10441389; uncharacterized protein 319617 4978230 An01g01340 Aspergillus niger uncharacterized protein XP_001388574.1 318138 R 5061 CDS An01g01350 4977118 join(320012..320266,320327..320553,320608..320686,320747..321220,321270..321713) II 1 NT_166518.1 Function: S. cerevisiae TNA1 encodes the yeast high affinity nicotinic acid permease.; Regulation: S. cerevisiae TNA1 is repressed by nicotinate and p-aminobenzoate.; Remark: the systematic name for S. cerevisiae TNA1 is YGR260W.; Similarity: S. cerevisiae TNA1 is a member of the yeast Dal5p subfamily of the major facilitator family.; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563; See PMID 10984621; uncharacterized protein 321713 4977118 An01g01350 Aspergillus niger uncharacterized protein XP_001388575.1 320012 D 5061 CDS An01g01360 4977582 complement(join(322013..322857,322917..323201,323257..323338)) II 1 NT_166518.1 Title: similarity to hypothetical transmembrane protein CAD18032.1 - Ralstonia solanacearum; uncharacterized protein 323338 4977582 An01g01360 Aspergillus niger uncharacterized protein XP_001388576.1 322013 R 5061 CDS An01g01370 4978194 join(323769..324420,324515..324541,324757..324783,324929..324997,325127..325284,325341..325717,325750..326257) II 1 NT_166518.1 Title: strong similarity to hypothetical protein encoded by An06g01030 - Aspergillus niger; uncharacterized protein 326257 4978194 An01g01370 Aspergillus niger uncharacterized protein XP_059603062.1 323769 D 5061 CDS An01g01380 4977341 complement(join(326663..328439,328498..329113,329189..329774,329918..330565)) II 1 NT_166518.1 Function: co-expression of het-e and het-c lead to cell death.; Function: het-e1 of P. anserina is responsible for vegetative incompatibility.; Remark: het-e1 of P. anserina shows also two sequence motifs, a GTP-binding domain and a repeated region that shares similarity with that of the beta-transducin.; Remark: the reactivity of the HET-E protein depends on two functional elements, a GTP-binding domain and several WD40 repeats.; Title: similarity to beta transducin-like protein het-e - Podospora anserina; See PMID 9435787; See PMID 10875280; See PMID 10974123; See PMID 7557402; uncharacterized protein 330565 4977341 An01g01380 Aspergillus niger uncharacterized protein XP_001388578.1 326663 R 5061 CDS An01g01390 4978263 join(331842..331871,331953..333381,333437..333984) II 1 NT_166518.1 Complex: the yeast SWI/SNF chromatin remodeling complex is comprised of 11 tightly associated polypeptides (SWI1, SWI2, SWI3, SNF5, SNF6, SNF11, SWP82, SWP73, SWP59 (Arp9), SWP61, and SWP29).; Function: S. cerevisiae Arp9 is a component of the RSC and SWI/SNF chromatin remodeling complex with structural roles, as the ATPase activity is not required for Arp9 function.; Remark: the systematic name for S. cerevisiae Arp9 is YMR033w an alias is SWP59.; Similarity: S. cerevisiae Arp9 is a member of the actin-related protein (ARP) family of ATPases.; Title: similarity to chromatin remodeling Snf/Swi complex subunit Arp9 - Saccharomyces cerevisiae; localisation:nucleus; See PMID 9726966; See PMID 9844636; See PMID 10529347; See PMID 10753786; uncharacterized protein 333984 4978263 An01g01390 Aspergillus niger uncharacterized protein XP_001388579.1 331842 D 5061 CDS An01g01400 4978113 complement(join(334615..334949,335021..335132)) II 1 NT_166518.1 Title: strong similarity to hypothetical protein encoded by slr0318 - Synechocystis sp.; uncharacterized protein 335132 4978113 An01g01400 Aspergillus niger uncharacterized protein XP_001388580.1 334615 R 5061 CDS An01g01410 84589837 complement(join(335563..335738,335797..335911)) II 1 NT_166518.1 Title: strong similarity to hypothetical protein encoded by An01g01460 - Aspergillus niger; uncharacterized protein 335911 84589837 An01g01410 Aspergillus niger uncharacterized protein XP_059603063.1 335563 R 5061 CDS An01g01420 84589838 complement(join(336861..337093,337168..337395,337462..337487,337537..337604,337659..338198)) II 1 NT_166518.1 Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea; uncharacterized protein 338198 84589838 An01g01420 Aspergillus niger uncharacterized protein XP_059603064.1 336861 R 5061 CDS An01g01430 4978228 join(338420..338602,338717..339137,339189..339250,339309..340232) II 1 NT_166518.1 Function: S. lavendulae mcrA protects this microorganism from its own antibiotic, the antitumor drug mitomycin C.; Function: the predicted A. niger protein shows high similarity to a putative FAD-dependent oxygenase encM from the enterocin biosynthetic gene cluster of Streptomyces maritimus and therefore might be involved in toxin synthesis.; Title: similarity to hydroquinone oxidase mcrA -Streptomyces lavendulae; See PMID 10468636; See PMID 11137817; uncharacterized protein 340232 4978228 An01g01430 Aspergillus niger uncharacterized protein XP_001388583.1 338420 D 5061 CDS An01g01440 84589839 join(341069..342041,342129..342172) II 1 NT_166518.1 Title: strong similarity to hypothetical protein CAD21096.1 - Neurospora crassa; uncharacterized protein 342172 84589839 An01g01440 Aspergillus niger uncharacterized protein XP_059603065.1 341069 D 5061 CDS An01g01450 4978409 join(342903..342937,343262..345536) II 1 NT_166518.1 hypothetical protein 345536 4978409 An01g01450 Aspergillus niger hypothetical protein XP_059603066.1 342903 D 5061 CDS An01g01460 84589840 join(347298..347415,347473..347657) II 1 NT_166518.1 Title: strong similarity to hypothetical protein encoded by An01g01410 - Aspergillus niger; uncharacterized protein 347657 84589840 An01g01460 Aspergillus niger uncharacterized protein XP_059603067.1 347298 D 5061 CDS An01g01470 4978369 complement(join(348060..348180,348273..348877)) II 1 NT_166518.1 Title: similarity to hypothetical protein encoded by An08g11970 - Aspergillus niger; uncharacterized protein 348877 4978369 An01g01470 Aspergillus niger uncharacterized protein XP_059603068.1 348060 R 5061 CDS An01g01475 4978510 350219..350719 II 1 NT_166518.1 hypothetical protein 350719 4978510 An01g01475 Aspergillus niger hypothetical protein XP_001388588.1 350219 D 5061 CDS An01g01480 84589841 complement(join(351211..351999,352002..352610)) II 1 NT_166518.1 Function: the S. cerevisiae antibiotic resistance protein QDR1 confers resistance to the antiarrhythmic and antimalarial quinoline ring-containing drug Quinidine.; Title: similarity to multidrug resistance protein Qdr1 - Saccharomyces cerevisiae; See PMID 11302822; uncharacterized protein 352610 84589841 An01g01480 Aspergillus niger uncharacterized protein XP_059603069.1 351211 R 5061 CDS An01g01490 4978468 join(352773..353728,353783..353909) II 1 NT_166518.1 Title: similarity to hypothetical protein B3E4.80 -Neurospora crassa; uncharacterized protein 353909 4978468 An01g01490 Aspergillus niger uncharacterized protein XP_001388590.1 352773 D 5061 CDS An01g01500 4978102 join(354593..354646,354697..354770,354825..355005,355060..355767) II 1 NT_166518.1 Function: mouse KIN17, a nuclear zinc finger protein, binds to the curved DNA fragments found at illegitimate recombination sites.; Function: overexpression of mouse KIN17 inhibits cellular proliferation.; Induction: mouse KIN17 is expressed after induction of S-phase and after UV-exposure.; Similarity: mouse KIN17 shares epitopes with the bacterial RecA protein, which controls the expression of the SOS UV-response genes.; Title: strong similarity to UV-response Zn-finger protein kin17 - Mus musculus; localisation:nucleus; See PMID 8078469; See PMID 9635863; See PMID 10413603; uncharacterized protein 355767 4978102 An01g01500 Aspergillus niger uncharacterized protein XP_001388591.1 354593 D 5061 CDS An01g01520 4978402 join(357464..357524,357606..358423) II 1 NT_166518.1 Catalytic activity: pyrroline-5-carboxylate reductases convert L-proline + NAD(P)(+) to 1-pyrroline-5-carboxylate + NAD(P)H.; Function: Z. arboricola P5CR plays a role in the final step of proline biosynthesis.; Remark: an alternative name for Z. arboricola P5CR is Delta 1-pyrroline-5-carboxylate reductase.; Title: similarity to pyrroline-5-carboxylate reductase P5CR - Zalerion arboricola; See PMID 8654976; uncharacterized protein 358423 4978402 An01g01520 Aspergillus niger uncharacterized protein XP_001388592.1 357464 D 5061 CDS An01g01530 4978371 join(358901..359496,359589..360402) II 1 NT_166518.1 Catalytic activity: proline dehydrogenases convert L-proline + acceptor + H(2)O to (S)-1-pyrroline-5-carboxylate + reduced acceptor.; Function: proline dehydrogenase is a mitochondrial enzyme which catalyzes the first step in the conversion of proline to glutamate.; Title: similarity to proline dehydrogenase slgA -Drosophila melanogaster; localisation:mitochondrium; See PMID 8096642; uncharacterized protein 360402 4978371 An01g01530 Aspergillus niger uncharacterized protein XP_001388593.1 358901 D 5061 CDS An01g01540 4978248 join(361954..361965,362017..363759,363804..364094,364140..365312) II 1 NT_166518.1 Function: A. nidulans treA is an acid trehalase required for utilisation of the extracellular disaccharide trehalose.; Localization: A. nidulans treA is localized in the conidiospore wall.; Title: strong similarity to alpha,alpha-trehalase treA - Aspergillus nidulans; localisation:cell wall; See PMID 9140977; See PMID 9308367; uncharacterized protein 365312 4978248 An01g01540 Aspergillus niger uncharacterized protein XP_001388594.1 361954 D 5061 CDS An01g01550 4978376 complement(join(365658..366583,366639..366813,366900..367064,367114..367529,367580..367805,367855..368130)) II 1 NT_166518.1 Catalytic activity: catalases convert 2 H(2)O(2) to O(2) + 2 H(2)O.; Function: catalase occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.; Title: strong similarity to catalase cat1 -Aspergillus fumigatus; See PMID 9353056; uncharacterized protein 368130 4978376 An01g01550 Aspergillus niger uncharacterized protein XP_001388595.1 365658 R 5061 CDS An01g01560 4978358 complement(join(369001..369082,369249..369815,369880..370325)) II 1 NT_166518.1 Title: similarity to hypothetical protein yxaG -Bacillus subtilis; uncharacterized protein 370325 4978358 An01g01560 Aspergillus niger uncharacterized protein XP_001388596.3 369001 R 5061 CDS An01g01580 4978364 complement(join(372140..372431,372498..373151,373209..373609)) II 1 NT_166518.1 Title: strong similarity to hypothetical protein encoded by An01g00420 - Aspergillus niger; uncharacterized protein 373609 4978364 An01g01580 Aspergillus niger uncharacterized protein XP_001388597.1 372140 R 5061 CDS An01g01590 4978355 complement(join(<374518..374874,374913..376267,376317..376776,376830..377083,377138..377207,377260..377437,377488..377570,377710..377801,377836..377942)) II 1 NT_166518.1 Function: pyruvate decarboxylase is the key enzyme in the glycolytic-fermentative pathway of ethanol production in fungi, and in certain plants and bacteria.; Remark: N. crassa harbors large amounts of cytoplasmic filaments which are homopolymers of a 59-kDa polypeptide, pyruvate decarboxylase.; Remark: a possible sequencing error occured at position 38662, giving rise to a frame-shift, and was removed.; Remark: the predicted A. niger protein shows similarities to pyruvate decarboxylase of N. crassa as well as of other organisms in its C-terminal region whereas the N-terminal region shows homologies to alcohol dehydrogenase enzymes.; Title: similarity to pyruvate decarboxylase PDC -Neurospora crassa [putative frameshift]; localisation:cytoplasm; putative frameshift; See PMID 8359692; uncharacterized protein 377942 4978355 An01g01590 Aspergillus niger uncharacterized protein XP_059603070.1 374518 R 5061 CDS An01g01600 4978447 join(380016..380337,380376..380492,380541..381448) II 1 NT_166518.1 Function: M. auratus MCT2 facilitates the cellular uptake of lactate, pyruvate and other monocarboxylates.; Similarity: M. auratus MCT2 belongs to the monocarboxylate transporter family.; Title: similarity to monocarboxylate transporter 2 MCT2 - Mesocricetus auratus; See PMID 7829520; uncharacterized protein 381448 4978447 An01g01600 Aspergillus niger uncharacterized protein XP_059603071.1 380016 D 5061 CDS An01g01620 4978362 386047..387099 II 1 NT_166518.1 Function: S. cerevisiae ZRT1 is involved in zinc import into the cell.; Induction: S. cerevisiae ZRT1 is expressed in response to zinc deficiency.; Remark: alternative names for S. cerevisiae ZRT1 are YGL255W and FZF1.; Title: strong similarity to high-affinity zinc transport protein Zrt1 - Saccharomyces cerevisiae; See PMID 8637895; See PMID 9618566; See PMID 10748254; uncharacterized protein 387099 4978362 An01g01620 Aspergillus niger uncharacterized protein XP_001388601.1 386047 D 5061 CDS An01g01630 4978365 complement(join(387878..388215,388387..388549)) II 1 NT_166518.1 Title: strong similarity to hypothetical protein encoded by An09g00510 - Aspergillus niger; uncharacterized protein 388549 4978365 An01g01630 Aspergillus niger uncharacterized protein XP_059603072.1 387878 R 5061 CDS An01g01640 4978190 complement(389389..390429) II 1 NT_166518.1 Catalytic activity: E. gunnii CAD 1 catalyzes the reversible oxidation of cinnamyl alcohol to cinnamacetaldehyde with the concomitant reduction of NADP.; Function: E. gunnii cinnamyl alcohol dehydrogenase is considered a key enzyme in lignin biosynthesis.; Pathway: E. gunnii CAD 1 is involved in lignin biosynthesis.; Title: strong similarity to cinnamyl-alcohol dehydrogenase CAD1 - Eucalyptus gunnii; See PMID 9526508; uncharacterized protein 390429 4978190 An01g01640 Aspergillus niger uncharacterized protein XP_001388603.3 389389 R 5061 CDS An01g01650 84589842 complement(join(391218..391243,391478..392273)) II 1 NT_166518.1 Title: similarity to hypothetical protein encoded by An12g05420 - Aspergillus niger; uncharacterized protein 392273 84589842 An01g01650 Aspergillus niger uncharacterized protein XP_059603073.1 391218 R 5061 CDS An01g01660 84589843 complement(join(393061..393388,393483..393574)) II 1 NT_166518.1 Function: Acinetobacter salE shows activity against short-chain alkyl esters of 4-nitrophenol but was also able to hydrolyze ethyl salicylate to ethanol and salicylic acid.; Title: weak similarity to alkyl salicylate esterase salE - Acinetobacter sp.; See PMID 10715011; uncharacterized protein 393574 84589843 An01g01660 Aspergillus niger uncharacterized protein XP_059603074.1 393061 R 5061 CDS An01g01670 4977125 complement(join(394875..395392,395455..396565)) II 1 NT_166518.1 Title: similarity to hypothetical protein encoded by An01g11590 - Aspergillus niger; uncharacterized protein 396565 4977125 An01g01670 Aspergillus niger uncharacterized protein XP_059603075.1 394875 R 5061 CDS An01g01680 84589844 join(397789..398165,398277..398422,398497..398582) II 1 NT_166518.1 Title: similarity to hypothetical protein encoded by An01g01690 - Aspergillus niger; uncharacterized protein 398582 84589844 An01g01680 Aspergillus niger uncharacterized protein XP_059603076.1 397789 D 5061 CDS An01g01690 84589845 complement(join(399024..399050,399117..399170,399367..399423,399664..399740,399785..400067)) II 1 NT_166518.1 Title: similarity to hypothetical protein encoded by An01g01680 - Aspergillus niger; uncharacterized protein 400067 84589845 An01g01690 Aspergillus niger uncharacterized protein XP_059603077.1 399024 R 5061 CDS An01g01700 84589846 join(400801..400903,400952..401316) II 1 NT_166518.1 hypothetical protein 401316 84589846 An01g01700 Aspergillus niger hypothetical protein XP_059603078.1 400801 D 5061 CDS An01g01710 84589847 join(402426..402517,402563..402644,402841..402993) II 1 NT_166518.1 hypothetical protein 402993 84589847 An01g01710 Aspergillus niger hypothetical protein XP_059603079.1 402426 D 5061 CDS An01g01720 4977514 complement(join(409076..409510,409567..410424,410459..410580,410633..410762)) II 1 NT_166518.1 Function: S. cerevisiae blh1 mutants show hypersensitivity to bleomycin, indicating that bleomycin hydrolase is able to inactivate bleomycin in vivo and to protect cells from bleomycin-induced toxicity.; Similarity: S. cerevisiae BLH1 is a member of the cysteine protease family.; Title: strong similarity to bleomycin hydrolase Blh1 - Saccharomyces cerevisiae; See PMID 8463237; uncharacterized protein 410762 4977514 An01g01720 Aspergillus niger uncharacterized protein XP_059603080.1 409076 R 5061 CDS An01g01730 84589848 complement(join(411539..412548,412652..412676)) II 1 NT_166518.1 Title: strong similarity to hypothetical protein encoded by An12g06350 - Aspergillus niger; uncharacterized protein 412676 84589848 An01g01730 Aspergillus niger uncharacterized protein XP_059603081.1 411539 R 5061 CDS An01g01740 84589849 complement(join(412935..412969,413035..413166,413234..413249,413302..413358,413421..413432)) II 1 NT_166518.1 Title: weak similarity to troponin C -Caenorhabditis elegans; uncharacterized protein 413432 84589849 An01g01740 Aspergillus niger uncharacterized protein XP_059603082.1 412935 R 5061 CDS An01g01750 4978472 complement(join(414491..414563,414649..414823,414893..415068,415120..415296,415351..415488,415541..415737,415781..416312,416364..416627,416673..416881)) II 1 NT_166518.1 Function: Rattus norvegicus CLN2 is a lysosomal protease.; Similarity: Rattus norvegicus CLN2 shows similarity to prokaryotic pepstatin-insensitive acid proteases.; Title: similarity to lysosomal protease CLN2 -Rattus norvegicus; localisation:lysosome; See PMID 10428067; uncharacterized protein 416881 4978472 An01g01750 Aspergillus niger uncharacterized protein XP_001388614.1 414491 R 5061 CDS An01g01760 84589850 complement(join(418508..418530,418567..418570,418756..418830)) II 1 NT_166518.1 Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 418830 84589850 An01g01760 Aspergillus niger uncharacterized protein XP_059603083.1 418508 R 5061 CDS An01g01770 84589851 join(419587..419631,419954..420041,420172..420270,420351..420423,420455..420509,420598..420687,421104..421358) II 1 NT_166518.1 hypothetical protein 421358 84589851 An01g01770 Aspergillus niger hypothetical protein XP_059603084.1 419587 D 5061 CDS An01g01780 4978166 join(423796..423963,424029..424949) II 1 NT_166518.1 Localization: PTH11 of M. grisea was localized as a GFP-fusion protein in the cell membrane and in the vacuoles.; Phenotype: pth11 mutants of strain 4091-5-8 are nonpathogenic due to a defect in appressorium differentiation. This suggests that Pth11p functions at the cell cortex as an upstream effector of appressorium differentiation.; Title: strong similarity to transmembrane protein PTH11 - Magnaporthe grisea; See PMID 10521529; uncharacterized protein 424949 4978166 An01g01780 Aspergillus niger uncharacterized protein XP_001388617.1 423796 D 5061 CDS An01g01790 4977232 complement(join(425160..425786,425844..425987,426051..426254,426308..426483,426536..426891,426943..427067)) II 1 NT_166518.1 Remark: Band 3 of the erythrocyte cytoskeleton is a central component taking part in two widely divergent functions of erythroid cells; it is a primary determinant of cytoskeletal architecture and responsible for electroneutral Cl-/HCO3- exchange across the plasma membrane.; Title: similarity to band 3 anion transport protein - Gallus gallus; See PMID 3185555; uncharacterized protein 427067 4977232 An01g01790 Aspergillus niger uncharacterized protein XP_059603085.1 425160 R 5061 CDS An01g01800 4977246 join(427645..427869,427923..427994,428048..428413,428463..428507,428554..428780,428831..429392,429571..429702) II 1 NT_166518.1 hypothetical protein 429702 4977246 An01g01800 Aspergillus niger hypothetical protein XP_059603086.1 427645 D 5061 CDS An01g01810 4977368 complement(join(430109..430218,430258..431361,431414..432130,432197..432302)) II 1 NT_166518.1 Function: plays a role in the entry into G0,possibly by facilitating the release of a signaling substance into the environment as a means of cell-to-cell communication.; Similarity: fnx1(+) encodes a protein with sequence similarity to the proton-driven plasma membrane transporters from the multidrug resistance group of the major facilitator superfamily of proteins.; Title: similarity to multidrug resistance protein fnx1p - Schizosaccharomyces pombe; See PMID 9710608; uncharacterized protein 432302 4977368 An01g01810 Aspergillus niger uncharacterized protein XP_001388620.3 430109 R 5061 CDS An01g01820 4978057 complement(join(432564..433655,433705..433869,433924..434339,434402..434627,434690..434983)) II 1 NT_166518.1 Catalytic activity: 2 H2O2 = O2 + 2 H2O; Function: occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.; Gene-ID: catR; Similarity: belongs to the catalase family.; localisation:peroxisome; See PMID 7934925; catalase R catR-Aspergillus niger 434983 catR 4978057 catR Aspergillus niger catalase R catR-Aspergillus niger XP_001388621.1 432564 R 5061 CDS An01g01830 4977099 436559..438847 II 1 NT_166518.1 Catalytic activity: 2 H2O2 = O2 + 2 H2O.; Function: Streptomyces reticuli produces a mycelium-associated enzyme (CpeB) which exhibits heme-dependent catalase and peroxidase activity, as well as heme-independent manganese-peroxidase activity. The catalase-peroxidase CpeB and its apo-form (obtained after extraction of heme catalyze the peroxidation of Mn(II) to Mn(III), independent of the presence or absence of the heme inhibitor KCN.; Title: strong similarity to catalase/peroxidase cpeB - Streptomyces reticuli; See PMID 10217488; See PMID 10806381; uncharacterized protein 438847 4977099 An01g01830 Aspergillus niger uncharacterized protein XP_001388622.1 436559 D 5061 CDS An01g01840 4977363 439169..440611 II 1 NT_166518.1 Catalytic activity: RCH2NH2 + H2O + O2 = RCHO + NH3 + H2O2; Remark: MAO oxidizes both serotonin [5-hydroxytryptamine (5-HT)] and beta-phenylethylamine (PEA), unlike human MAO-A and MAO-B, which oxidize only 5-HT and PEA, respectively.; Title: strong similarity to monoamine oxidase MAO -Oncorhynchus mykiss; See PMID 7808446; uncharacterized protein 440611 4977363 An01g01840 Aspergillus niger uncharacterized protein XP_001388623.1 439169 D 5061 CDS An01g01850 4978073 join(441440..443311,443428..443550) II 1 NT_166518.1 Function: co-expression of het-e and het-c lead to cell death.; Function: het-e1 of P. anserina is responsible for vegetative incompatibility.; Remark: het-e1 of P. anserina shows also two sequence motifs, a GTP-binding domain and a repeated region that shares similarity with that of the beta-transducin.; Remark: the reactivity of the HET-E protein depends on two functional elements, a GTP-binding domain and several WD40 repeats.; Title: similarity to beta transducin-like protein het-e1 - Podospora anserina; See PMID 9435787; See PMID 10875280; See PMID 10974123; See PMID 7557402; uncharacterized protein 443550 4978073 An01g01850 Aspergillus niger uncharacterized protein XP_059603087.1 441440 D 5061 CDS An01g01860 10098211 complement(join(444536..444751,444900..445109)) II 1 NT_166518.1 Remark: Homology is only based on repetitive sequence.; Title: similarity to hypothetical protein encoded by An17g00940 - Aspergillus niger; uncharacterized protein 445109 10098211 An01g01860 Aspergillus niger uncharacterized protein XP_059603088.1 444536 R 5061 CDS An01g01870 4977095 join(446938..447037,447085..447229,447273..447471,447518..447758,447808..447861,447907..449703,449735..449784) II 1 NT_166518.1 Function: putative cellulase.; Similarity: fungal cellulose-binding domain homology.; Title: strong similarity to hypothetical Avicelase III aviIII - Aspergillus aculeatus; uncharacterized protein 449784 4977095 An01g01870 Aspergillus niger uncharacterized protein XP_059603089.1 446938 D 5061 CDS An01g01880 4977180 complement(449958..451163) II 1 NT_166518.1 Catalytic activity: (s)-lactate + o(2) = acetate + co(2) + h(2)o.; Similarity: belongs to the fmn-dependent alpha-hydroxy acid dehydrogenases family.; Title: strong similarity to L-lactate 2-monooxygenase LA2M - Mycobacterium smegmatis; See PMID 9341146; See PMID 2324094; uncharacterized protein 451163 4977180 An01g01880 Aspergillus niger uncharacterized protein XP_001388627.1 449958 R 5061 CDS An01g01890 84589852 join(452001..452149,452187..452445,452531..452725,452848..453300) II 1 NT_166518.1 hypothetical protein 453300 84589852 An01g01890 Aspergillus niger hypothetical protein XP_059603090.1 452001 D 5061 CDS An01g01900 4978353 join(454927..455345,455410..456020,456077..456323,456381..456504,456565..456789) II 1 NT_166518.1 Function: Mct is a component of a novel drug export system specific to the mitomycins. Mct encodes a hydrophobic polypeptide that has significant amino acid sequence similarity with several actinomycete antibiotic export proteins.; Title: strong similarity to mitomycin C translocase mct - Streptomyces lavendulae; See PMID 10198016; uncharacterized protein 456789 4978353 An01g01900 Aspergillus niger uncharacterized protein XP_001388629.1 454927 D 5061 CDS An01g01920 4977548 complement(join(457714..459315,459362..459834,459883..459937)) II 1 NT_166518.1 Catalytic activity: hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.; Similarity: similarity to bacterial and eukaryotic beta-N-acetylhexosaminidases.; Title: similarity to beta-N-acetylhexosaminidase -Vibrio furnissii; See PMID 8969206; See PMID 10398828; uncharacterized protein 459937 4977548 An01g01920 Aspergillus niger uncharacterized protein XP_001388630.1 457714 R 5061 CDS An01g01930 84589853 complement(join(460754..461222,461482..461524,461671..462013)) II 1 NT_166518.1 hypothetical protein 462013 84589853 An01g01930 Aspergillus niger hypothetical protein XP_059603091.1 460754 R 5061 CDS An01g01940 4977524 complement(join(463553..463729,463791..464838,464905..464958,465009..465055,465122..465415)) II 1 NT_166518.1 Function: UGA4 of S. cerevisiae is a GABA-specific high-affinity permease.; Title: strong similarity to GABA permease Uga4 -Saccharomyces cerevisiae; See PMID 7888172; See PMID 8455553; uncharacterized protein 465415 4977524 An01g01940 Aspergillus niger uncharacterized protein XP_001388632.1 463553 R 5061 CDS An01g01950 4977112 complement(join(467286..467871,467930..468435)) II 1 NT_166518.1 Similarity: all yeast homologs are about 400 aminoacids longer at N-terminus.; Similarity: bacterial homologs have about the same length.; Title: similarity to aluminium resistance protein Alr1 - Saccharomyces cerevisiae; See PMID 9430719; See PMID 10220002; uncharacterized protein 468435 4977112 An01g01950 Aspergillus niger uncharacterized protein XP_001388633.1 467286 R 5061 CDS An01g01960 4977358 470513..471340 II 1 NT_166518.1 Catalytic activity: catalyzes the reduction of 2,4 diamino-6-ribitylamino-4(3H)-pyrimidine 5'-phosphate by NADPH to yield DRTP.; Pathway: riboflavin biosynthesis (second step).; Title: strong similarity to riboflavin biosynthesis protein Rib7 - Saccharomyces cerevisiae; See PMID 3547188; See PMID 8256517; uncharacterized protein 471340 4977358 An01g01960 Aspergillus niger uncharacterized protein XP_001388634.3 470513 D 5061 CDS An01g01970 84589854 complement(join(471856..471860,471917..472243,472301..472604)) II 1 NT_166518.1 Title: similarity to hypothetical protein encoded by An04g02750 - Aspergillus niger; uncharacterized protein 472604 84589854 An01g01970 Aspergillus niger uncharacterized protein XP_059603092.1 471856 R 5061 CDS An01g01980 4977919 join(473738..474681,474712..475185,475221..475353) II 1 NT_166518.1 hypothetical protein 475353 4977919 An01g01980 Aspergillus niger hypothetical protein XP_059603093.1 473738 D 5061 CDS An01g01990 84589855 join(476179..476245,476295..476470) II 1 NT_166518.1 hypothetical protein 476470 84589855 An01g01990 Aspergillus niger hypothetical protein XP_059603094.1 476179 D 5061 CDS An01g02000 4977430 join(477442..477490,477600..478530,478587..478881,478963..479157) II 1 NT_166518.1 Catalytic activity: L-Tryptophan = Tryptamine + CO2; EC:4.1.1.28; Pathway: Histidine metabolism; Tyrosine metabolism; Phenylalanine metabolism; Tryptophan metabolism; Alkaloid biosynthesis I.; Title: similarity to aromatic-L-amino-acid decarboxylase DDC - Rattus norvegicus; See PMID 7567987; uncharacterized protein 479157 4977430 An01g02000 Aspergillus niger uncharacterized protein XP_059603095.1 477442 D 5061 CDS An01g02010 84589856 479790..480995 II 1 NT_166518.1 Similarity: blast matches to acid rich proteins due to serine and aspartic acids repeats.; hypothetical protein 480995 84589856 An01g02010 Aspergillus niger hypothetical protein XP_059603096.1 479790 D 5061 CDS An01g02020 4977024 join(481538..481618,481671..481776,481868..481948,482007..482041) II 1 NT_166518.1 Title: strong similarity to hypothetical protein ssl3291 - Synechocystis sp.; uncharacterized protein 482041 4977024 An01g02020 Aspergillus niger uncharacterized protein XP_001388640.1 481538 D 5061 CDS An01g02030 84589857 complement(join(482341..483721,483830..484170,484249..484323,484393..484674,484769..485640,485793..485888,485938..486460)) II 1 NT_166518.1 Function: FUM5 of G. fujikuroi is a PKS gene required for fumonisin biosynthesis.; Remark: all homologs are N-terminal much longer.; Title: similarity to polyketide synthase FUM5 -Gibberella moniliformis; See PMID 10413619; See PMID 10802562; See PMID 10872449; contains an internal stop codon; uncharacterized protein; 486460 84589857 An01g02030 Aspergillus niger 482341 R 5061 CDS An01g02040 84589858 join(487264..487440,487519..487795,487845..488263,488317..488964) II 1 NT_166518.1 hypothetical protein 488964 84589858 An01g02040 Aspergillus niger hypothetical protein XP_059603097.1 487264 D 5061 CDS An01g02050 4977055 complement(join(489382..490429,490479..490527,490623..491550)) II 1 NT_166518.1 Remark: At221 might be involved in the gene expression regulation of lovF.; Title: similarity to gene expression regulator At221 from patent WO200257456-A2 - Unclassified organism; uncharacterized protein 491550 4977055 An01g02050 Aspergillus niger uncharacterized protein XP_001388643.3 489382 R 5061 CDS An01g02060 4978079 join(492021..492070,492118..492334,492396..493172,493238..493351,493436..493540,493719..493748) II 1 NT_166518.1 Similarity: similarity to YOR306c, YNL125c, YKL221w and monocarboxylate transporter proteins.; Title: similarity to monocarboxylate transporter 3 -Gallus gallus; See PMID 9168967; uncharacterized protein 493748 4978079 An01g02060 Aspergillus niger uncharacterized protein XP_059603098.1 492021 D 5061 CDS An01g02070 4977749 complement(join(493813..494002,494072..494486,494532..495082,495125..495513,495560..495910)) II 1 NT_166518.1 Function: A. fumigatus secretes a serine alkaline protease (ALP) and a metalloprotease (MEP) when the fungus is cultivated in the presence of collagen as sole nitrogen and carbon source.; Remark: putative sequencing error at position 82586 (Stop); Remark: strong similarity to metalloproteases from aspergillus.; Title: strong similarity to metalloprotease mep -Aspergillus fumigatus; extracellular/secretion proteins; See PMID 7715453; uncharacterized protein 495910 4977749 An01g02070 Aspergillus niger uncharacterized protein XP_001388645.1 493813 R 5061 CDS An01g02080 4978103 complement(join(496556..496594,496672..496771,496831..497234)) II 1 NT_166518.1 Title: similarity to hypothetical protein SC2G5.30 -Streptomyces coelicolor; uncharacterized protein 497234 4978103 An01g02080 Aspergillus niger uncharacterized protein XP_059603099.1 496556 R 5061 CDS An01g02090 4977351 join(499043..499116,499239..499426,499537..502572,502624..502667) II 1 NT_166518.1 Title: similarity to hypothetical protein BX908807_12 - Neurospora crassa; uncharacterized protein 502667 4977351 An01g02090 Aspergillus niger uncharacterized protein XP_059603100.1 499043 D 5061 CDS An01g02100 4978144 complement(join(503174..504345,504413..504446)) II 1 NT_166518.1 Function: Pus4p of S. cerevisiae catalyzes the formation of psi55 in both mitochondrial and cytoplasmic tRNAs.; Title: strong similarity to tRNA-pseudouridine synthase Pus4 - Saccharomyces cerevisiae; See PMID 9358157; uncharacterized protein 504446 4978144 An01g02100 Aspergillus niger uncharacterized protein XP_001388648.3 503174 R 5061 CDS An01g02110 4977838 join(505103..505307,505394..505662,505738..505896,505952..507046,507131..507160,507211..507246) II 1 NT_166518.1 Title: similarity to hypothetical protein CAD11409.1 - Neurospora crassa; uncharacterized protein 507246 4977838 An01g02110 Aspergillus niger uncharacterized protein XP_001388649.3 505103 D 5061 CDS An01g02120 4978298 complement(join(507483..507793,507875..508658)) II 1 NT_166518.1 Function: Ebp2p of S. cerevisiae is required for the maturation of 25S rRNA and 60S subunit assembly; it may be one of the target proteins of Rrs1p for executing the signal to regulate ribosome biogenesis.; Remark: EbP2p is the genename for YKL172w of S. cerevisiae.; Similarity: shows also similarity to human nucleolar protein p40.; Title: strong similarity to nucleolar protein Ebp2 -Saccharomyces cerevisiae; nucleus; See PMID 10849420; See PMID 10947841; See PMID 11226172; uncharacterized protein 508658 4978298 An01g02120 Aspergillus niger uncharacterized protein XP_001388650.1 507483 R 5061 CDS An01g02130 84589859 509974..511188 II 1 NT_166518.1 Function: het-6 of N. crassa is involved in the restriction of heterokaryon formation during asexual growth.; Remark: in filamentous fungi, vegetative cell fusion between genotypically distinct individuals leads to a cell-death reaction known as vegetative or heterokaryon incompatibility.; Similarity: het-6(OR) of N. crassa has three regions of amino acid sequence similarity to the predicted product of the het-e vegetative incompatibility gene in P. anserina and to the predicted product of tol, which mediates mating-type vegetative incompatibility in N. crassa.; Title: similarity to heterokaryon incompatibility protein het-6 - Neurospora crassa; See PMID 10880472; See PMID 11035941; See PMID 11092825; uncharacterized protein 511188 84589859 An01g02130 Aspergillus niger uncharacterized protein XP_059603101.1 509974 D 5061 CDS An01g02140 4977970 complement(join(513646..513913,513981..514017,514068..514587,514636..514887,514962..515133,515221..515462)) II 1 NT_166518.1 Remark: the deletion of YGR260w in a bna1 auxotrophic mutant for nicotinic acid prevents growth at low nicotinic acid concentration. This suggests that YGR260w is necessary for nicotinic acid import into the cell.; Remark: the systematic name for TNA1 of S. cerevisiae is YGR260w.; Similarity: the ORF shows similarity to some allantoate permeases.; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 8720066; See PMID 10373489; uncharacterized protein 515462 4977970 An01g02140 Aspergillus niger uncharacterized protein XP_059603102.1 513646 R 5061 CDS An01g02150 4978245 complement(join(516465..516855,516907..517071,517120..517820,517870..517999,518111..518691)) II 1 NT_166518.1 Function: arcA of A. nidulans is, together with suDpro and suEpro, responsible for regulation of synthesis of arginine catabolic enzymes.; Title: strong similarity to transcription regulator of arginine catabolism arcA - Aspergillus nidulans; See PMID 62492; uncharacterized protein 518691 4978245 An01g02150 Aspergillus niger uncharacterized protein XP_059603103.1 516465 R 5061 CDS An01g02160 4977221 complement(519563..521134) II 1 NT_166518.1 Function: fnx1 of S. pombe required for entry into the quiescent G0 state, that is normally induced by nitrogen starvation.; Similarity: similarity to several multidrug resistance proteins.; Title: strong similarity to multidrug resistance protein fnx1p - Schizosaccharomyces pombe; See PMID 9710608; uncharacterized protein 521134 4977221 An01g02160 Aspergillus niger uncharacterized protein XP_059603104.1 519563 R 5061 CDS An01g02170 4978373 join(523220..523457,523561..523787,523875..524159) II 1 NT_166518.1 Similarity: similarity to S. pombe hypothetical protein SPAC13C5. 04, similarity to several esterases; Title: similarity to anthranilate converting enzyme tdnT - Pseudomonas putida; See PMID 8990291; uncharacterized protein 524159 4978373 An01g02170 Aspergillus niger uncharacterized protein XP_001388655.1 523220 D 5061 CDS An01g02180 4977609 complement(join(524349..524385,524548..525203)) II 1 NT_166518.1 Title: similarity to hypothetical protein YOL032w -Saccharomyces cerevisiae; uncharacterized protein 525203 4977609 An01g02180 Aspergillus niger uncharacterized protein XP_001388656.3 524349 R 5061 CDS An01g02190 4978339 join(525648..525688,525754..526681) II 1 NT_166518.1 Catalytic activity: ATP + Thiamine = AMP + Thiamine diphosphate.; Pathway: Thiamine metabolism.; Title: similarity to thiamin pyrophosphokinase tnr3p - Schizosaccharomyces pombe; See PMID 6282163; See PMID 7499352; uncharacterized protein 526681 4978339 An01g02190 Aspergillus niger uncharacterized protein XP_001388657.1 525648 D 5061 CDS An01g02200 4978231 complement(join(526894..526999,527094..527422)) II 1 NT_166518.1 Catalytic activity: nucleoside triphosphate + RNA(n) = Pyrophosphate + RNA(n+1).; Remark: RNA polymerases I, II, and III of S. cerevisiae share three subunits that are immunologically and biochemically indistinguishable (RPB5, RPB6, and RPB8).; Title: strong similarity to 16 kD subunit of DNA-directed RNA polymerase I,II,III Rpb8 - Saccharomyces cerevisiae; nucleus; See PMID 1408842; See PMID 10653691; uncharacterized protein 527422 4978231 An01g02200 Aspergillus niger uncharacterized protein XP_001388658.1 526894 R 5061 CDS An01g02210 4978305 join(527707..528178,528248..528957) II 1 NT_166518.1 Title: similarity to hypothetical protein SPCC11E10.06c - Schizosaccharomyces pombe; uncharacterized protein 528957 4978305 An01g02210 Aspergillus niger uncharacterized protein XP_001388659.1 527707 D 5061 CDS An01g02220 4978399 join(529861..530368,530491..>530814) II 1 NT_166518.1 Complex: in S. cerevisiae the tRNA splicing endonuclease is a tetrameric enzyme.; Function: in S. cerevisiae the tRNA splicing endonuclease is responsible for identification and cleavage of the splice sites in pre-tRNA.; Function: splicing of tRNA precursors is essential for the production of mature tRNA.; Title: strong similarity to tRNA splicing endonuclease gamma subunit Sen34 - Saccharomyces cerevisiae [putative frameshift]; putative frameshift; See PMID 9200603; uncharacterized protein 530814 4978399 An01g02220 Aspergillus niger uncharacterized protein XP_059603105.1 529861 D 5061 CDS An01g02230 4977688 complement(join(531751..531956,532022..532544)) II 1 NT_166518.1 Remark: ribonuclease P is involved in processing of tRNAs and rRNAs.; Title: similarity to ribonuclease P protein subunit p29 - Homo sapiens; See PMID 9759486; See PMID 10024167; uncharacterized protein 532544 4977688 An01g02230 Aspergillus niger uncharacterized protein XP_001388661.1 531751 R 5061 CDS An01g02240 4978435 join(533332..533640,533745..534440) II 1 NT_166518.1 Similarity: shows similarity to several oxidoreductases with different specificities, e. g 1-aminocyclopropane-1-carboxylic acid oxidases.; Title: similarity to 1-aminocyclopropane-1-carboxylic acid oxidase - Cucumis sativus; See PMID 10608661; uncharacterized protein 534440 4978435 An01g02240 Aspergillus niger uncharacterized protein XP_059603106.1 533332 D 5061 CDS An01g02250 4978445 complement(join(534769..535556,535646..536275,536335..537781)) II 1 NT_166518.1 Title: weak similarity to hypothetical AAA-ATPase AAR34299.1 - Geobacter sulfurreducens; uncharacterized protein 537781 4978445 An01g02250 Aspergillus niger uncharacterized protein XP_059603107.1 534769 R 5061 CDS An01g02260 4978134 join(538785..538954,539007..539322,539370..539568,539643..539990,540046..540989) II 1 NT_166518.1 Similarity: C-terminus shows weak similarity to central part of bacterial ftsZ proteins.; Title: strong similarity to hypothetical protein encoded by An07g04490 - Aspergillus niger; uncharacterized protein 540989 4978134 An01g02260 Aspergillus niger uncharacterized protein XP_001388664.3 538785 D 5061 CDS An01g02270 84589860 complement(join(543263..543329,543384..543868,544284..544343,544392..544446,544823..544875,544949..544984)) II 1 NT_166518.1 Catalytic activity: rinonuclease H catalyzes the endonucleolytic cleavage to 5'-phospho- monoester.; Function: ribonuclease H is an endonuclease that degrades the RNA of RNA-DNA hybrids specifically.; Title: similarity to ribonuclease H1 RNH1 -Trypanosoma brucei; See PMID 9178276; uncharacterized protein 544984 84589860 An01g02270 Aspergillus niger uncharacterized protein XP_059603108.1 543263 R 5061 CDS An01g02280 4978467 complement(join(547069..547243,547288..547371,547427..547621,547679..548242,548297..548484,548800..549324)) II 1 NT_166518.1 Similarity: shows only weak similarity to N-terminal part of hypothetical protein DR0458 of Deinococcus radiodurans.; hypothetical protein 549324 4978467 An01g02280 Aspergillus niger hypothetical protein XP_059603109.1 547069 R 5061 CDS An01g02290 84589861 join(551475..551616,551659..551717,551896..551958) II 1 NT_166518.1 hypothetical protein 551958 84589861 An01g02290 Aspergillus niger hypothetical protein XP_059603110.1 551475 D 5061 CDS An01g02300 4977096 complement(join(553719..553910,553982..554112,554261..554360,554435..554437)) II 1 NT_166518.1 Similarity: all matching proteins are 20-50 aminoacids longer at the C-terminus.; Title: similarity to glia maturation factor BmGMF -Brugia malayi; See PMID 7820553; See PMID 9047337; uncharacterized protein 554437 4977096 An01g02300 Aspergillus niger uncharacterized protein XP_001388668.1 553719 R 5061 CDS An01g02310 4977067 join(554879..554965,555083..555249,555347..555974) II 1 NT_166518.1 Remark: shows similarity to several bacterial competence-damage proteins.; Title: strong similarity to hypothetical protein YMR178w - Saccharomyces cerevisiae; uncharacterized protein 555974 4977067 An01g02310 Aspergillus niger uncharacterized protein XP_001388669.3 554879 D 5061 CDS An01g02320 4978153 complement(join(557217..557452,557523..557798,557865..557979,558131..558142)) II 1 NT_166518.1 Function: Aras of A. nidulans is an essential gene that regulates the ordered program of development.; Title: strong similarity to GTP-binding protein a-ras - Aspergillus nidulans; See PMID 8035812; See PMID 10835388; uncharacterized protein 558142 4978153 An01g02320 Aspergillus niger uncharacterized protein XP_001388670.1 557217 R 5061 CDS An01g02330 4977427 complement(join(562453..562771,562807..562889,563061..563104,563523..563860,563926..564560,564646..565031,565093..565630)) II 1 NT_166518.1 Title: similarity to pyoverdine biosynthesis protein PvcA - Pseudomonas aeruginosa; See PMID 8704959; See PMID 10383985; uncharacterized protein 565630 4977427 An01g02330 Aspergillus niger uncharacterized protein XP_001388671.3 562453 R 5061 CDS An01g02340 4978302 complement(join(566557..566722,566802..566857,566913..567222,567279..567583)) II 1 NT_166518.1 Similarity: shows strong similarity to several dehydrogenases.; Title: strong similarity to hypothetical short chain dehydrogenase SPAC521.03 - Schizosaccharomyces pombe; uncharacterized protein 567583 4978302 An01g02340 Aspergillus niger uncharacterized protein XP_001388672.3 566557 R 5061 CDS An01g02350 84589862 complement(join(571543..571673,571928..572129,572300..572602,572893..572931)) II 1 NT_166518.1 Remark: the human NK cell antigen DX1 has the patent-number WO9502611-A.; Title: weak similarity to NK cell antigen DX1 - Homo sapiens; uncharacterized protein 572931 84589862 An01g02350 Aspergillus niger uncharacterized protein XP_059603111.1 571543 R 5061 CDS An01g02360 4978450 join(572993..573187,573259..573295,573349..573416,573458..573846,573977..574418) II 1 NT_166518.1 Function: M. grisea pth11p is a plasma membrane protein that mediates appressorium differentiation in response to inductive substrate cues.; Remark: putative short form of M. grisea pth11p.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529; uncharacterized protein 574418 4978450 An01g02360 Aspergillus niger uncharacterized protein XP_059603112.1 572993 D 5061 CDS An01g02370 4978083 complement(join(576509..577344,577409..577947,578013..578347)) II 1 NT_166518.1 Function: the Aspergillus nidulans SREA is involved in regulation of siderophore biosynthesis and control of iron uptake.; Title: strong similarity to siderophore biosynthesis repressor sREA - Aspergillus nidulans; See PMID 9988696; uncharacterized protein 578347 4978083 An01g02370 Aspergillus niger uncharacterized protein XP_001388675.1 576509 R 5061 CDS An01g02380 84589863 join(579029..579144,579237..579394,579688..579754,579875..580034) II 1 NT_166518.1 hypothetical protein 580034 84589863 An01g02380 Aspergillus niger hypothetical protein XP_059603113.1 579029 D 5061 CDS An01g02390 84589864 complement(join(580095..580205,580295..580364,580460..580674,581065..581080,581173..581259,581317..581363,581496..581585)) II 1 NT_166518.1 hypothetical protein 581585 84589864 An01g02390 Aspergillus niger hypothetical protein XP_059603114.1 580095 R 5061 CDS An01g02400 84589865 join(581952..582025,582283..582409,582518..582618,582729..582882) II 1 NT_166518.1 hypothetical protein 582882 84589865 An01g02400 Aspergillus niger hypothetical protein XP_059603115.1 581952 D 5061 CDS An01g02410 4977110 complement(join(<583313..583485,583546..583635,583698..583813,583882..584019,584187..584375)) II 1 NT_166518.1 Title: similarity to hypothetical protein SPAC6F12.04 - Schizosaccharomyces pombe [putative frameshift]; putative frameshift; uncharacterized protein 584375 4977110 An01g02410 Aspergillus niger uncharacterized protein XP_001388679.3 583313 R 5061 CDS An01g02420 4978148 complement(join(584681..584994,585062..585776)) II 1 NT_166518.1 Title: similarity to hypothetical protein SC6F7.17c - Streptomyces coelicolor; uncharacterized protein 585776 4978148 An01g02420 Aspergillus niger uncharacterized protein XP_001388680.1 584681 R 5061 CDS An01g02430 4978383 complement(join(586098..586817,586871..586974,587025..587110,587197..587349,587413..587441)) II 1 NT_166518.1 Catalytic activity: the F. solani D-amino acid oxidase converts D-amino acid and H2O and O2 to 2-oxo acid and NH3 and H2O2.; Catalytic activity: the F. solani D-amino acid oxidase is able to oxidatively deaminate cephalosporin C to 7-beta-(5-carboxy-5-oxopentanamido)cephalosporanic acid.; Remark: the D-amino acid oxidase posseses a wide specificity for D-amino acids and also acts on glycine.; Title: strong similarity to D-amino-acid oxidase DAO - Fusarium solani; peroxisome; See PMID 1982443; uncharacterized protein 587441 4978383 An01g02430 Aspergillus niger uncharacterized protein XP_059603116.1 586098 R 5061 CDS An01g02440 4978363 join(588488..588713,588810..589237,589289..590047) II 1 NT_166518.1 Title: similarity to hypothetical protein K21H1.13 -Arabidopsis thaliana; uncharacterized protein 590047 4978363 An01g02440 Aspergillus niger uncharacterized protein XP_001388682.1 588488 D 5061 CDS An01g02460 4978095 complement(join(592328..593782,593847..594032,594085..594621)) II 1 NT_166518.1 Title: strong similarity to hypothetical protein EAA66045.1 - Aspergillus nidulans; uncharacterized protein 594621 4978095 An01g02460 Aspergillus niger uncharacterized protein XP_001388683.3 592328 R 5061 CDS An01g02470 84589866 join(595077..595142,595217..595347,595413..595463,595544..595732,595820..595939,596047..596166,596268..596442) II 1 NT_166518.1 hypothetical protein 596442 84589866 An01g02470 Aspergillus niger hypothetical protein XP_059603117.1 595077 D 5061 CDS An01g02480 84589867 complement(join(596831..596926,597180..597479,597539..597616)) II 1 NT_166518.1 hypothetical protein 597616 84589867 An01g02480 Aspergillus niger hypothetical protein XP_059603118.1 596831 R 5061 CDS An01g02490 84589868 complement(join(598714..598733,598824..598933,598989..599064,599145..599448)) II 1 NT_166518.1 hypothetical protein 599448 84589868 An01g02490 Aspergillus niger hypothetical protein XP_059603119.1 598714 R 5061 CDS An01g02500 4977411 complement(join(600708..601005,601137..601165)) II 1 NT_166518.1 Function: thioredoxin is involved in oxidative stress response and redox regulation.; Localization: the S. cerevisiae TRX1 and TRX2 are located in the cytoplasm, while TRX3 is located in the mitochondrion.; Remark: the A. nidulans thioredoxin is an intercellular disulphide-reducing enzyme which exhibits an unusual fluorescence emission spectrum, characterized by a high contribution of tyrosine residues.; Remark: the amino acid sequence of A. nidulans thioredoxin was determined by automated Edman degradation.; Similarity: the A. nidulans thioredoxin displays a sequence similarity of 45% to at least one of three thioredoxin homologues in S. cerevisiae TRX1, TRX2 and TRX3.; Title: strong similarity to thioredoxin -Aspergillus nidulans; See PMID 1459127; uncharacterized protein 601165 4977411 An01g02500 Aspergillus niger uncharacterized protein XP_001388687.1 600708 R 5061 CDS An01g02510 4977271 complement(602579..604975) II 1 NT_166518.1 hypothetical protein 604975 4977271 An01g02510 Aspergillus niger hypothetical protein XP_001388688.1 602579 R 5061 CDS An01g02520 84589869 complement(join(605868..605887,605969..605973,606004..606214,606296..606308)) II 1 NT_166518.1 hypothetical protein 606308 84589869 An01g02520 Aspergillus niger hypothetical protein XP_059603120.1 605868 R 5061 CDS An01g02530 84589870 complement(join(607903..607995,608018..608070,608170..608236)) II 1 NT_166518.1 hypothetical protein 608236 84589870 An01g02530 Aspergillus niger hypothetical protein XP_059603121.1 607903 R 5061 CDS An01g02540 84589871 join(608463..608548,609190..609418) II 1 NT_166518.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 609418 84589871 An01g02540 Aspergillus niger uncharacterized protein XP_059603122.1 608463 D 5061 CDS An01g02550 84589872 complement(join(610068..610143,610240..610292,610486..610545)) II 1 NT_166518.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 610545 84589872 An01g02550 Aspergillus niger uncharacterized protein XP_059603123.1 610068 R 5061 CDS An01g02560 84589873 join(610974..611159,612025..612255) II 1 NT_166518.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 612255 84589873 An01g02560 Aspergillus niger uncharacterized protein XP_059603124.1 610974 D 5061 CDS An01g02570 84589874 join(612991..613178,613277..613304,613416..613452,613509..613598,613667..613743,613826..613891) II 1 NT_166518.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 613891 84589874 An01g02570 Aspergillus niger uncharacterized protein XP_059603125.1 612991 D 5061 CDS An01g02590 84589875 complement(614462..614635) II 1 NT_166518.1 hypothetical protein 614635 84589875 An01g02590 Aspergillus niger hypothetical protein XP_059603126.1 614462 R 5061 CDS An01g02600 4978075 join(614759..614780,614879..615002,615065..615253,615305..617420,617475..617570) II 1 NT_166518.1 Remark: the adaptin complex proteins are involved in the formation of clathrin coated pits and vesicels.; Similarity: the predicted A. niger protein reveals two conserved domains, the adaptin N-terminal region (aa 24-587, PF01602) and the C-terminal gamma-adaptin domain (aa 726-848, PF02139), who are together part of the adaptin complex (AP-complex).; Title: strong similarity to gamma1-adaptin - Homo sapiens; See PMID 9733768; uncharacterized protein 617570 4978075 An01g02600 Aspergillus niger uncharacterized protein XP_059603127.1 614759 D 5061 CDS An01g02610 84589876 complement(join(618864..619004,619092..619166,619534..619757,619809..619919,619967..620246)) II 1 NT_166518.1 Title: strong similarity to EST an_2155 -Aspergillus niger; uncharacterized protein 620246 84589876 An01g02610 Aspergillus niger uncharacterized protein XP_059603128.1 618864 R 5061 CDS An01g02620 4977915 join(621072..621231,621613..621723,621789..621916,622013..622270) II 1 NT_166518.1 Function: A. oryzae nuclear protein HAPC binds specifically to a CCAAT sequence in the promoter region of the A. oryzae Taka-amylase A gene.; Similarity: the predicted A. niger protein contains a CBFD-NFYB-HMF domain (aa 47-115, PF00808) which is typical for histone like transcription factors.; Title: strong similarity to CCAAT-binding protein hapC - Aspergillus oryzae; nucleus; See PMID 10905428; uncharacterized protein 622270 4977915 An01g02620 Aspergillus niger uncharacterized protein XP_003188527.1 621072 D 5061 CDS An01g02630 4978061 complement(join(623303..624449,624509..625761)) II 1 NT_166518.1 Pathway: amdR in A. oryzae and in A. nidulans is involved in the capability of the fungi to grow on gamma-amino-butyric acid (GABA) as a carbon and/or nitrogen source.; Similarity: the N-terminal region of the predicted A. niger protein contains a fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain.; Title: strong similarity to transcription regulator amdR - Aspergillus nidulans; nucleus; See PMID 1479891; uncharacterized protein 625761 4978061 An01g02630 Aspergillus niger uncharacterized protein XP_001388699.3 623303 R 5061 CDS An01g02640 4977851 complement(join(626570..626880,626938..627395,627452..627575,627656..627779,627870..628193)) II 1 NT_166518.1 Catalytic activity: omtB of A. parasiticus catalyzes the conversion of demethylsterigmatocystin (DMST) to sterigmatocystin (ST) and dihydrodemethylsterigmatocystin (DHDMST) to dihydrosterigmatocystin (DHST).; Pathway: omtB of A. parasiticus is a component of the aflatoxin biosynthesis gene cluster.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Remark: omtB of A. parasiticus is also called dmtA.; Title: strong similarity to O-methyltransferase B omtB - Aspergillus parasiticus; See PMID 10806361; uncharacterized protein 628193 4977851 An01g02640 Aspergillus niger uncharacterized protein XP_001388700.1 626570 R 5061 CDS An01g02650 84589877 complement(join(628416..628536,628892..629004,629097..629149,629231..629320,629542..629765,629894..629983,630108..630232)) II 1 NT_166518.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 630232 84589877 An01g02650 Aspergillus niger uncharacterized protein XP_059603129.1 628416 R 5061 CDS An01g02660 4977350 join(630725..630895,631054..631349,631403..631647,631707..631737,631815..632175) II 1 NT_166518.1 Title: strong similarity to hypothetical protein encoded by An03g05810 - Aspergillus niger; uncharacterized protein 632175 4977350 An01g02660 Aspergillus niger uncharacterized protein XP_059603130.1 630725 D 5061 CDS An01g02670 4977069 complement(join(632522..633483,633514..633703)) II 1 NT_166518.1 Function: the S. pombe scn1 protein interact with the CUT9 protein, a putative component of anaphse-promoting complex (APC) which is required for cyclin degradation and metaphase-anaphase transition.; Function: the predicted S. pombe scn1 protein contains a TatD related DNAse domain (aa 19-357, PF01026),a feature of a large superfamily of metalloenzymes.; Remark: the S. cerevisiae homolog of S. pombe scn1 is YMR262W.; Title: strong similarity to hypothetical protein scn1p - Schizosaccharomyces pombe; See PMID 7798319; uncharacterized protein 633703 4977069 An01g02670 Aspergillus niger uncharacterized protein XP_059603131.1 632522 R 5061 CDS An01g02680 4977348 634142..635380 II 1 NT_166518.1 hypothetical protein 635380 4977348 An01g02680 Aspergillus niger hypothetical protein XP_001388704.1 634142 D 5061 CDS An01g02690 4977170 complement(join(635816..636091,636251..637348,637416..637583)) II 1 NT_166518.1 Remark: information regarding S. cerevisiae ICT1 has not yet been published and is available from SGD and MIPS.; Similarity: the predicted A. niger protein shows similarity to S. cerevisiae ICT1, disruption of ICT1 leads to enhanced sensitivity to benomyl and azoles.; Title: strong similarity to hypothetical protein SPAC6G10.03c - Schizosaccharomyces pombe; uncharacterized protein 637583 4977170 An01g02690 Aspergillus niger uncharacterized protein XP_059603132.1 635816 R 5061 CDS An01g02700 4977871 join(638437..639055,639150..639832) II 1 NT_166518.1 Title: similarity to hypothetical protein SPBC902.03 - Schizosaccharomyces pombe; uncharacterized protein 639832 4977871 An01g02700 Aspergillus niger uncharacterized protein XP_059603133.1 638437 D 5061 CDS An01g02720 4978167 complement(join(641378..641414,641477..643548,643606..643869,643925..644030,644081..644127,644197..644248,644321..644339,644398..644464)) II 1 NT_166518.1 Complex: the six S. cerevisiae MCM proteins (MCM2-7) interact with each other to form predominantly a hexameric complex containing all six MCM proteins but also other smaller subcomplexes.; Function: S. cerevisiae MCM3 is a helicase subunit involved in DNA replication initiation, DNA unwinding and in the pre-replicative complex formation and its maintenance.; Similarity: the predicted A. niger protein contains a MCM 2/3/5 domain (aa 110-664, PF00493) which is a component of proteins required for the initiation of DNA replication.; Title: strong similarity to replication helicase subunit Mcm3 - Saccharomyces cerevisiae; nucleus; See PMID 2233713; See PMID 9427284; See PMID 10980206; uncharacterized protein 644464 4978167 An01g02720 Aspergillus niger uncharacterized protein XP_001388707.1 641378 R 5061 CDS An01g02730 4978139 complement(join(644902..645521,645593..645659)) II 1 NT_166518.1 Remark: the C. lindemuthianum CIH1 is a fungal glycoprotein specifically located at the biotrophic interface formed in the Colletotrichum lindemuthianum-bean interaction.; Title: similarity to proline-rich glycoprotein CIH1 - Colletotrichum lindemuthianum; plasma membrane; See PMID 9721685; uncharacterized protein 645659 4978139 An01g02730 Aspergillus niger uncharacterized protein XP_001388708.3 644902 R 5061 CDS An01g02740 4977166 complement(join(646643..647362,647435..648481)) II 1 NT_166518.1 Catalytic activity: the A. oryzae tannase converts digallate and H(2)O to 2 gallate.; Remark: an alternate name for tannase is tannin hydrolase and tannin acetylhydrolase.; Remark: tannase is an esterase that hydrolyses the acyl esters of tannins, making tannins more soluble at a lower temperature and pH.; Remark: the ORF shows strong similarity to patent JP08080196-A in PATENTPROT:AAR93195.; Title: strong similarity to tannase precursor from patent JP08080196-A - Aspergillus oryzae; See PMID 8917102; uncharacterized protein 648481 4977166 An01g02740 Aspergillus niger uncharacterized protein XP_001388709.1 646643 R 5061 CDS An01g02750 84589878 join(649696..649739,649792..650197,650247..650372) II 1 NT_166518.1 Title: weak similarity to hypothetical protein CAC28656.1 - Neurospora crassa; uncharacterized protein 650372 84589878 An01g02750 Aspergillus niger uncharacterized protein XP_059603134.1 649696 D 5061 CDS An01g02760 4978235 complement(650688..651305) II 1 NT_166518.1 Title: weak similarity to killer toxin Khr -Saccharomyces cerevisiae; See PMID 1368554; uncharacterized protein 651305 4978235 An01g02760 Aspergillus niger uncharacterized protein XP_001388711.1 650688 R 5061 CDS An01g02770 84589879 complement(join(651423..651463,651554..651651,651728..651795,651935..652027)) II 1 NT_166518.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 652027 84589879 An01g02770 Aspergillus niger uncharacterized protein XP_059603135.1 651423 R 5061 CDS An01g02790 4978290 complement(join(652747..653713,653789..656634)) II 1 NT_166518.1 Function: a N. crassa cya-5 mutant contains coxI mRNA but the COXI protein could not be detected. The CYA-5 protein of N. crassa is required in a post-transcriptional step for COXI expression, most probably for the efficient translation of coxI mRNA.; Localization: CYA-5 is a nuclear encoded protein. A mitochondrial targeting sequence at its amino-terminus suggests a mitochondrial localization.; Title: strong similarity to COXI translation protein CYA-5 - Neurospora crassa; See PMID 9342407; uncharacterized protein 656634 4978290 An01g02790 Aspergillus niger uncharacterized protein XP_059603136.1 652747 R 5061 CDS An01g02800 4978210 join(657121..657311,657405..658547,658603..659110) II 1 NT_166518.1 Complex: the signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.; Function: the signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7s RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the er membrane and possibly participate in the elongation arrest function.; Title: strong similarity to signal recognition particle 68K protein SRP68 - Canis lupus; cytoplasm; See PMID 1702390; See PMID 6292236; See PMID 8388879; uncharacterized protein 659110 4978210 An01g02800 Aspergillus niger uncharacterized protein XP_001388714.1 657121 D 5061 CDS An01g02810 4978239 join(661184..661343,661416..661566,661652..662900,662953..662988) II 1 NT_166518.1 Cofactor: Heme.; Function: Erg5 is a cytochrome P450 involved in C-22 denaturation of the ergosterol side-chain.; Pathway: S. cerevisiae Erg5 is involved in the Ergosterol biosynthesis.; Remark: alternate names for S. cerevisiae Erg5: Cyp61, YMR015c.; Similarity: S. cerevisiae Erg5 belongs to the cytochrome p450 family.; Title: strong similarity to cytochrome P450 sterol delta22-desaturase Erg5 - Saccharomyces cerevisiae; See PMID 7791529; See PMID 8635732; See PMID 331007; See PMID 10390230; uncharacterized protein 662988 4978239 An01g02810 Aspergillus niger uncharacterized protein XP_001388715.1 661184 D 5061 CDS An01g02820 84589880 join(665173..665272,665452..665661,665745..665779,665860..665901) II 1 NT_166518.1 hypothetical protein 665901 84589880 An01g02820 Aspergillus niger hypothetical protein XP_059603137.1 665173 D 5061 CDS An01g02830 4978111 join(666258..666545,666601..666978) II 1 NT_166518.1 Title: similarity to heat shock protein 67B2 -Drosophila melanogaster; See PMID 2454316; uncharacterized protein 666978 4978111 An01g02830 Aspergillus niger uncharacterized protein XP_001388717.1 666258 D 5061 CDS An01g02840 4978286 complement(join(667632..667875,667930..670412,670490..670948)) II 1 NT_166518.1 Function: IF2 is a translation factor that catalyzes the binding of initiator methionyl-tRNA to the ribosomal P site.; Title: strong similarity to translation initiation factor IF2 - Homo sapiens; See PMID 10200264; uncharacterized protein 670948 4978286 An01g02840 Aspergillus niger uncharacterized protein XP_001388718.1 667632 R 5061 CDS An01g02850 4978309 complement(join(671577..673019,673070..673236,673300..674854,674914..675028,675083..675639)) II 1 NT_166518.1 hypothetical protein 675639 4978309 An01g02850 Aspergillus niger hypothetical protein XP_059603138.1 671577 R 5061 CDS An01g02860 4978107 join(676989..677238,677288..677419,677466..678352) II 1 NT_166518.1 Title: similarity to hypothetical protein SPBC651.03c - Schizosaccharomyces pombe; uncharacterized protein 678352 4978107 An01g02860 Aspergillus niger uncharacterized protein XP_001388720.1 676989 D 5061 CDS An01g02870 4978163 join(678584..678745,678804..678855,678924..679629,679711..679801) II 1 NT_166518.1 Title: similarity to hypothetical protein SPAC227.06 - Schizosaccharomyces pombe; uncharacterized protein 679801 4978163 An01g02870 Aspergillus niger uncharacterized protein XP_001388721.3 678584 D 5061 CDS An01g02880 4978136 complement(join(680256..680342,680452..680562,680798..680978,681102..681108,681196)) II 1 NT_166518.1 Title: strong similarity to cytoplasmic ubiquitin / ribosomal fusion protein Cep52 - Saccharomyces cerevisiae [putative frameshift]; cytoplasm; putative frameshift; uncharacterized protein 681196 4978136 An01g02880 Aspergillus niger uncharacterized protein XP_001388722.1 680256 R 5061 CDS An01g02890 4978183 complement(join(681265..681372,681408..681489,681549..681579,681695..682111,682162..682548,682599..682737,682791..682896,682953..683197,683414..683416)) II 1 NT_166518.1 Complex: forms a complex with the other RRN proteins RRN6 and RRN11.; Function: involved in the transcription of 35S rRNA genes by the core domain of RNA polymerase I.; Title: similarity to protein Rrn7 - Saccharomyces cerevisiae; See PMID 7958901; See PMID 8887672; uncharacterized protein 683416 4978183 An01g02890 Aspergillus niger uncharacterized protein XP_059603139.1 681265 R 5061 CDS An01g02900 4978101 complement(join(684340..684410,684479..684611,684670..684936,685162..685173)) II 1 NT_166518.1 Function: Translation intitiation factor eIF-5A (previously named eIF-4D) is a highly conserved protein that promotes formation of the first peptide bond. One of its lysine residues is posttranslationally modified by spermidine to form hypusine. eIF-5a is essential for cell growth in yeast cells.; Title: strong similarity to translation initiation factor Eif-5a.2 - Saccharomyces cerevisiae; See PMID 1903841; uncharacterized protein 685173 4978101 An01g02900 Aspergillus niger uncharacterized protein XP_001388724.1 684340 R 5061 CDS An01g02910 4977152 join(685681..686547,686600..686894,686949..687769) II 1 NT_166518.1 Title: strong similarity to hypothetical ARE1-like protein F3I17.5 - Arabidopsis thaliana; uncharacterized protein 687769 4977152 An01g02910 Aspergillus niger uncharacterized protein XP_001388725.3 685681 D 5061 CDS An01g02920 4977525 join(688177..688392,688472..688597,688674..689663) II 1 NT_166518.1 Title: similarity to hypothetical protein PA5145 -Pseudomonas aeruginosa; uncharacterized protein 689663 4977525 An01g02920 Aspergillus niger uncharacterized protein XP_001388726.3 688177 D 5061 CDS An01g02930 4977011 690505..691287 II 1 NT_166518.1 Title: similarity to hypothetical protein encoded by An12g09280 - Aspergillus niger; uncharacterized protein 691287 4977011 An01g02930 Aspergillus niger uncharacterized protein XP_001388727.1 690505 D 5061 CDS An01g02940 4977503 complement(join(691397..692438,692483..692607,692655..692705,692751..692873,692920..693991,694059..694113,694162..694237)) II 1 NT_166518.1 Remark: the similarity is restricted to the C2H2-type zinc finger motif.; Title: weak similarity to regulator protein Mhy1 -Yarrowia lipolytica; uncharacterized protein 694237 4977503 An01g02940 Aspergillus niger uncharacterized protein XP_059603140.1 691397 R 5061 CDS An01g02950 4977564 complement(join(696265..698561,698623..699285,699334..699985,700061..700563,700631..701627)) II 1 NT_166518.1 Title: similarity to hypothetical protein CAD21096.1 - Neurospora crassa; uncharacterized protein 701627 4977564 An01g02950 Aspergillus niger uncharacterized protein XP_001388729.3 696265 R 5061 CDS An01g02960 4977038 complement(join(702178..702327,702380..702498,702549..702903,702960..703597,703651..703879)) II 1 NT_166518.1 Catalytic activity: homogentisate + o(2) = 4-maleylacetoacetate.; Pathway: The HmgA protein catalyzes an essential step in phenylalanine catabolism.; Remark: defects in homogentisate dioxygenase are the cause of alkaptonuria, an autosomal recessive error of metabolism which is characterized by an increase in the level of homogentisic acid.; Title: strong similarity to 3,4-dihydroxyphenylacetate 2,3-dioxygenase hmgA - Aspergillus nidulans; See PMID 7673153; uncharacterized protein 703879 4977038 An01g02960 Aspergillus niger uncharacterized protein XP_001388730.3 702178 R 5061 CDS An01g02970 4977097 complement(704561..705994) II 1 NT_166518.1 Function: PcaB confers the ability to use 4-hydroxybenzoate or protocatechuate as the only carbon source. Hydroxyaromatics catabolism by pcaB serves both nutritional and detoxifying purposes.; Title: strong similarity to 3-carboxy-cis,cis-muconate cycloisomerase pcaB - Bradyrhizobium japonicum; See PMID 9582432; uncharacterized protein 705994 4977097 An01g02970 Aspergillus niger uncharacterized protein XP_001388731.1 704561 R 5061 CDS An01g02980 84589881 join(706891..707019,707066..707177,707225..707298,707343..707366,707457..707783) II 1 NT_166518.1 Title: similarity to hypothetical protein CG7415 -Drosophila melanogaster; uncharacterized protein 707783 84589881 An01g02980 Aspergillus niger uncharacterized protein XP_059603141.1 706891 D 5061 CDS An01g02990 4977198 join(708426..708791,708856..708945) II 1 NT_166518.1 hypothetical protein 708945 4977198 An01g02990 Aspergillus niger hypothetical protein XP_001388733.3 708426 D 5061 CDS An01g03000 4977961 join(709725..709986,710055..710249,710313..710699,710765..711109,711172..711269,711329..711556) II 1 NT_166518.1 Title: strong similarity to hypothetical succinyl-CoA:3-ketoacid-CoA transferase SCOT - Homo sapiens; uncharacterized protein 711556 4977961 An01g03000 Aspergillus niger uncharacterized protein XP_001388734.1 709725 D 5061 CDS An01g03010 4977912 complement(711799..712074) II 1 NT_166518.1 hypothetical protein 712074 4977912 An01g03010 Aspergillus niger hypothetical protein XP_001388735.1 711799 R 5061 CDS An01g03020 4977352 complement(join(712979..713674,713705..713742,713828..713841,713899..713933,714201..714281,714315..714344)) II 1 NT_166518.1 hypothetical protein 714344 4977352 An01g03020 Aspergillus niger hypothetical protein XP_059603142.1 712979 R 5061 CDS An01g03030 4977631 join(714732..714981,715033..715871) II 1 NT_166518.1 Catalytic activity: multiple catalytic activities of TDH: as tartrate dehydrogenase catalyzes the oxidation of (R,R)-tartrate to oxaloglycolate by NAD+ and enables the organism to grow with tartrate as the sole carbon source; as D-malate dehydrogenase catalyzes the oxidative decarboxylation of D-malate to pyruvate and carbon dioxide by NAD+; as tartrate decarboxylase catalyzes the decarboxylation of meso-tartrate to D-glycerate and carbon dioxide.; Title: strong similarity to tartrate dehydrogenase TDH - Pseudomonas putida; See PMID 2184888; See PMID 8053675; uncharacterized protein 715871 4977631 An01g03030 Aspergillus niger uncharacterized protein XP_001388737.1 714732 D 5061 CDS An01g03040 4977798 join(716367..716436,716501..718178,718301..718796) II 1 NT_166518.1 Similarity: the ORF shows similarity to some transcription factors.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; uncharacterized protein 718796 4977798 An01g03040 Aspergillus niger uncharacterized protein XP_059603143.1 716367 D 5061 CDS An01g03050 4977463 complement(join(719656..719716,719787..721921)) II 1 NT_166518.1 Function: The poly(A)-binding protein (PABP) is the major mRNA-binding protein in eukaryotes, and it is essential for viability of the yeast S. cerevisiae.; Localization: The nuclear protein appears to be derived from the cytoplasmic one by proteolytic cleavage into 53 and 17 kd polypeptides.; Remark: The proteins has four tandemly arrayed 90 amino acid regions of homology that probably represent poly(A)-binding domains.; Title: similarity to polyadenylate-binding protein Pabp - Saccharomyces cerevisiae; See PMID 3537727; See PMID 1675426; uncharacterized protein 721921 4977463 An01g03050 Aspergillus niger uncharacterized protein XP_059603144.1 719656 R 5061 CDS An01g03060 4977620 complement(join(723548..724219,724276..727293)) II 1 NT_166518.1 Function: pub1 (protein ubiquitin ligase 1) catalyzes the attachment of the small protein ubiquitin to proteins such as the mitotic activating tyrosine phosphatase cdc25 thus specifically marking them for degradation by proteasomes.; Title: similarity to ubiquitin protein ligase ub1p -Schizosaccharomyces pombe; See PMID 8635463; See PMID 9197411; uncharacterized protein 727293 4977620 An01g03060 Aspergillus niger uncharacterized protein XP_001388740.1 723548 R 5061 CDS An01g03070 4977270 complement(join(728781..729002,729081..729263)) II 1 NT_166518.1 Title: similarity to mitochondrial ribosomal protein Yml27 - Saccharomyces cerevisiae; See PMID 1764528; mitochondrial 54S ribosomal protein mL41 729263 4977270 An01g03070 Aspergillus niger mitochondrial 54S ribosomal protein mL41 XP_001388741.1 728781 R 5061 CDS An01g03080 4977913 join(729584..732322,732411..732593) II 1 NT_166518.1 Title: strong similarity to hypothetical coiled-coil protein - Schizosaccharomyces pombe; uncharacterized protein 732593 4977913 An01g03080 Aspergillus niger uncharacterized protein XP_001388742.1 729584 D 5061 CDS An01g03090 4978417 join(734393..734554,734608..735136,735192..735301,735350..737077,737133..737194,737248..737584) II 1 NT_166518.1 Catalytic activity: hydrolysis of 1,3-beta-D-glucosidic linkages in 1,3-beta-D-glucans.; Function: Gel1 of A. fumigatus has a role in cell wall biosynthesis.; Localization: Gel1 of A. fumigatus is anchored to the plasma membrane via a glycosylphosphatidylinositol linkage.; Remark: Gel1 of A. fumigatus was originally called ENGL1.; Remark: the official name for 1,3-beta-glucanosyltransferase is glucan endo-1,3-beta-D-glucosidase.; Similarity: Gel1 of A. fumigatus belongs to family 72 of glycosylhydrolases.; Title: strong similarity to 1,3-beta-glucanosyltransferase gel1 - Aspergillus fumigatus; plasma membrane; See PMID 9846753; See PMID 10769178; See PMID 10809732; uncharacterized protein 737584 4978417 An01g03090 Aspergillus niger uncharacterized protein XP_059603145.1 734393 D 5061 CDS An01g03100 4978464 join(741159..741539,741617..742467,742534..742606) II 1 NT_166518.1 Function: HUM1 is required for vacuolar Ca2+/H+ exchange and is related to mammalian Na+/Ca2+ exchangers.; Remark: A single nucleotide change in the MNR1 gene determines resistance to manganese in S. cerevisiae. MNR1 was shown to correspond to HUM1, which determines a vacuolar membrane protein.; Title: strong similarity to manganese resistance protein 1 Mnr1 - Saccharomyces cerevisiae; See PMID 8668190; See PMID 10219995; uncharacterized protein 742606 4978464 An01g03100 Aspergillus niger uncharacterized protein XP_003188529.1 741159 D 5061 CDS An01g03110 4978346 join(743281..743628,743747..744079,744152..744570,744643..744670,744868..745008) II 1 NT_166518.1 Title: similarity to ribosomal protein of the small subunit Rsm7 - Saccharomyces cerevisiae; mitochondrial 37S ribosomal protein uS7m 745008 4978346 An01g03110 Aspergillus niger mitochondrial 37S ribosomal protein uS7m XP_001388745.3 743281 D 5061 CDS An01g03120 4978469 join(745747..745829,745988..747251,747310..748429,748493..748634,748769..748805) II 1 NT_166518.1 Function: a synthetic lethal phenotype was observed in S. cerevisiae when additional to Pho90 four other phosphate transporters were inactivated.; Remark: the identical protein match in the patent database uses wrong codes and descriptions.; Title: strong similarity to phosphate transport protein Pho90 - Saccharomyces cerevisiae; plasma membrane; See PMID 11779791; uncharacterized protein 748805 4978469 An01g03120 Aspergillus niger uncharacterized protein XP_001388746.3 745747 D 5061 CDS An01g03130 4978451 complement(join(749507..749513,749665..750443)) II 1 NT_166518.1 Remark: Protein is rich in proline, glutamine and glutamatic acid.; Title: weak similarity to surface protein PspC -Streptococcus pneumoniae; uncharacterized protein 750443 4978451 An01g03130 Aspergillus niger uncharacterized protein XP_001388747.1 749507 R 5061 CDS An01g03140 4978470 join(752058..752551,753321..753350,753796..753844,753963..753997,754028..754097,754451..754501,754550..754591) II 1 NT_166518.1 Remark: unspecific blast hits are due to the low complexity sequence of the ORF.; Title: weak similarity to hypothetical protein encoded by An12g10460 - Aspergillus niger; uncharacterized protein 754591 4978470 An01g03140 Aspergillus niger uncharacterized protein XP_059603146.1 752058 D 5061 CDS An01g03150 4978390 join(755202..755293,755348..756155) II 1 NT_166518.1 Title: strong similarity to hypothetical protein EAA66565.1 - Aspergillus nidula; uncharacterized protein 756155 4978390 An01g03150 Aspergillus niger uncharacterized protein XP_001388749.3 755202 D 5061 CDS An01g03160 4978400 join(756995..757068,757152..757680) II 1 NT_166518.1 Complex: S8 is one of the protein constituents of the 40S subunit of eucaryotic ribosomes.; Function: involved in eucaryotic protein synthesis.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit S8 - Rattus norvegicus; cytoplasm; See PMID 3684599; See PMID 8910435; 40S ribosomal protein eS8 757680 4978400 An01g03160 Aspergillus niger 40S ribosomal protein eS8 XP_001388750.1 756995 D 5061 CDS An01g03170 4978398 758131..759162 II 1 NT_166518.1 Title: similarity to hypothetical protein CG16717 -Drosophila melanogaster; uncharacterized protein 759162 4978398 An01g03170 Aspergillus niger uncharacterized protein XP_001388751.1 758131 D 5061 CDS An01g03180 4978408 complement(759634..765984) II 1 NT_166518.1 Function: Drosophila Mbc encodes a conserved protein that is essential for myoblast fusion, dorsal closure, and cytoskeletal organization.; Pathway: It is suggested that Mbc is a specific upstream regulator of the activity of the GTPase Rac that mediates several morphogenetic processes in Drosophila embryogenesis.; Title: similarity to myoblast city protein Mbc -Drosophila melanogaster; See PMID 9245788; See PMID 9808621; uncharacterized protein 765984 4978408 An01g03180 Aspergillus niger uncharacterized protein XP_001388752.1 759634 R 5061 CDS An01g03190 4978487 complement(join(768397..769315,769375..770492,770567..772854,772925..773123)) II 1 NT_166518.1 Function: SEC3 is one of ten SEC genes required for targeting or fusion of post-Golgi secretory vesicles to the plasma membrane in S. cerevisiae. It is suggested that polarized secretion would result from the coupling of actin-dependent vesicle targeting with SEC3-dependent establishment of the vesicle fusion site.; Title: similarity to protein Sec3 - Saccharomyces cerevisiae; plasma membrane; See PMID 9247645; See PMID 9491896; uncharacterized protein 773123 4978487 An01g03190 Aspergillus niger uncharacterized protein XP_059603147.1 768397 R 5061 CDS An01g03200 84589882 complement(join(773971..774008,774139..774193,774267..774983,775050..775399,775467..775634,775691..775940)) II 1 NT_166518.1 Remark: Incorporated choline is exclusively utilized for the synthesis of phosphatidylcholine.; Title: similarity to choline permease Hnm1 -Saccharomyces cerevisiae; See PMID 2203793; uncharacterized protein 775940 84589882 An01g03200 Aspergillus niger uncharacterized protein XP_059603148.1 773971 R 5061 CDS An01g03210 4978132 complement(776654..777628) II 1 NT_166518.1 Function: NADPH:protochlorophyllide oxidoreductase (POR) catalyses the light-dependent reduction of protochlorophyllide to chlorophyllide, a key reaction in the chlorophyll biosynthetic pathway.; Localization: POR is a peripheral protein located on the stromal side of the thylakoid membrane.; Title: similarity to proteophosphoglycan ppg3 -Pisum sativum; See PMID 7579182; See PMID 9224639; uncharacterized protein 777628 4978132 An01g03210 Aspergillus niger uncharacterized protein XP_001388755.1 776654 R 5061 CDS An01g03220 4978396 777933..779495 II 1 NT_166518.1 Remark: the systematic name of Upc2 from S. cerevisiae is YDR213w.; Title: similarity to hypothetical RNA polymerase II transcription factor Upc2 - Saccharomyces cerevisiae; uncharacterized protein 779495 4978396 An01g03220 Aspergillus niger uncharacterized protein XP_001388756.1 777933 D 5061 CDS An01g03230 4978389 join(779953..780012,780082..781200) II 1 NT_166518.1 Similarity: the similarities are due to repetetive sequences.; hypothetical protein 781200 4978389 An01g03230 Aspergillus niger hypothetical protein XP_001388757.1 779953 D 5061 CDS An01g03240 4978452 complement(781851..783725) II 1 NT_166518.1 Title: weak similarity to hypothetical protein B23I11.30 - Neurospora crassa; uncharacterized protein 783725 4978452 An01g03240 Aspergillus niger uncharacterized protein XP_059603149.1 781851 R 5061 CDS An01g03250 4978483 join(784604..784935,785004..786112,786177..786316) II 1 NT_166518.1 Pathway: TRI4 of Fusarium sporotrichioides catalyzes the first oxygenation step in the trichothecene pathway and participates in apotrichodiol biosynthesis.; Remark: TRI4 has been placed in a new cytochrome P450 gene family designated CYP58.; Remark: trichothecenes are sesquiterpenoid mycotoxins and act as protein synthesis inhibitors for eukaryotic organisms.; Title: strong similarity to cytochrome P450 monooxygenase TRI4 - Fusarium sporotrichioides; See PMID 7651333; uncharacterized protein 786316 4978483 An01g03250 Aspergillus niger uncharacterized protein XP_001388759.1 784604 D 5061 CDS An01g03260 4978484 complement(join(786746..786844,786955..787034,787108..787234)) II 1 NT_166518.1 Title: similarity to hypothetical mitochondrial ribosomal protein of the small subunit S37 - Saccharomyces cerevisiae; mitochondrial 37S ribosomal protein mS37 787234 4978484 An01g03260 Aspergillus niger mitochondrial 37S ribosomal protein mS37 XP_001388760.1 786746 R 5061 CDS An01g03270 4977339 join(787507..787881,787943..789046,789321..789626) II 1 NT_166518.1 Title: strong similarity to hypothetical conserved protein B24M22.130 - Neurospora crassa; uncharacterized protein 789626 4977339 An01g03270 Aspergillus niger uncharacterized protein XP_001388761.3 787507 D 5061 CDS An01g03280 10098151 791886..>792635 II 1 NT_166518.1 Remark: C-terminally truncated due to contig border.; hypothetical protein [truncated ORF]; 792635 10098151 An01g03280 Aspergillus niger 791886 D 5061 CDS An01g03290 84589883 <792858..793121 II 1 NT_166518.1 Remark: no start codon due to end of contig.; Title: weak similarity to hypothetical lipoprotein nlpD - Synechocystis sp. [truncated ORF]; 793121 84589883 An01g03290 Aspergillus niger 792858 D 5061 CDS An01g03300 84589884 complement(join(<794345..794461,794537..794931,795055..795633)) II 1 NT_166518.1 Function: E. coli iucB functions as N epsilon-hydroxylysine:acetyl coenzyme A N epsilon-transacetylase involved in biosynthesis of aerobactin.; Function: E. coli iucB is involved in iron uptake through biosynthesis of the low molecular weight iron specific chelator (siderophore) aerobactin, a hydroxamate compound.; Regulation: expression of E. coli iucB is iron dependent.; Title: strong similarity to siderophore synthesizing acetylase iucB - Escherichia coli [putative frameshift]; putative frameshift; See PMID 2935523; See PMID 2973985; See PMID 4313071; uncharacterized protein 795633 84589884 An01g03300 Aspergillus niger uncharacterized protein XP_059599548.1 794345 R 5061 CDS An01g03310 4978283 complement(join(796670..797529,797833..798091)) II 1 NT_166518.1 Function: human Crym is a NADP-regulated thyroid hormone receptor.; Localization: human Crym was purified from cytosol.; Similarity: human Crym shows similarity to bacterial lysine cyclodeaminase and ornithine cyclodeaminase.; Title: similarity to thyroid hormone-binding protein mu-crystallin Crym - Homo sapiens; cytoplasm; putative frameshift; uncharacterized protein 798091 4978283 An01g03310 Aspergillus niger uncharacterized protein XP_059599549.1 796670 R 5061 CDS An01g03320 84589885 join(798778..798807,798857..798977,799067..799275,799311..799409) II 1 NT_166518.1 hypothetical protein 799409 84589885 An01g03320 Aspergillus niger hypothetical protein XP_059599570.1 798778 D 5061 CDS An01g03330 4978411 complement(799765..801063) II 1 NT_166518.1 Complex: interaction of A. nidulans pclA with a PSTAIRE kinase was shown in vivo.; Function: A. nidulans pclA might mediate cell cycle events during late stages of sporulation.; Function: mutations of A. nidulans pclA show reduced production of conidia.; Induction: in A. nidulans expression of pclA was strongly induced by ectopic expression of brlA or abaA under conidiation-suppressing conditions.; Title: strong similarity to Pcl-like cyclin pclA -Aspergillus nidulans; See PMID 11359914; uncharacterized protein 801063 4978411 An01g03330 Aspergillus niger uncharacterized protein XP_001388765.1 799765 R 5061 CDS An01g03340 4977580 complement(join(802844..803246,803313..803635)) II 1 NT_166518.1 Function: A. aculeatus xyloglucan-specific endo-beta-1,4-glucanase hydrolyzes structurally diverse xyloglucans from various sources, but hydrolyzes no other cell wall component.; Title: strong similarity to xyloglucan-specific endo-beta-1,4-glucanase - Aspergillus aculeatus; See PMID 9884411; uncharacterized protein 803635 4977580 An01g03340 Aspergillus niger uncharacterized protein XP_001388766.1 802844 R 5061 CDS An01g03350 4978252 join(804754..805036,805113..805139,805216..805553) II 1 NT_166518.1 Function: N. crassa erg-1 is involved in the terminal steps of ergosterol biosynthesis, catalysing deltaC8 -> deltaC7 isomerisation.; Title: strong similarity to C-8 sterol isomerase erg-1 - Neurospora crassa; See PMID 154056; uncharacterized protein 805553 4978252 An01g03350 Aspergillus niger uncharacterized protein XP_001388767.1 804754 D 5061 CDS An01g03360 4977588 join(805910..806728,806951..807157) II 1 NT_166518.1 Title: strong similarity to hypothetical protein SPBC2G5.03 - Schizosaccharomyces pombe; uncharacterized protein 807157 4977588 An01g03360 Aspergillus niger uncharacterized protein XP_059599571.1 805910 D 5061 CDS An01g03370 4977239 complement(join(807780..808392,808460..808539,808599..809027,809079..810555,810930..811116,811194..811515,811593..811835)) II 1 NT_166518.1 Function: D. discoideum aimless is involved in the processing of chemotactic signals through G-protein-coupled receptors.; Function: mutations in D. discoideum aimless impaire both chemotaxis and activation of adenylyl cyclase.; Title: similarity to aimless RasGEF aleA -Dictyostelium discoideum; See PMID 8793298; uncharacterized protein 811835 4977239 An01g03370 Aspergillus niger uncharacterized protein XP_059599572.1 807780 R 5061 CDS An01g03390 4978050 complement(join(814577..815075,815147..815217)) II 1 NT_166518.1 Title: weak similarity to hypothetical protein CAD21197.1 - Neurospora crassa; uncharacterized protein 815217 4978050 An01g03390 Aspergillus niger uncharacterized protein XP_001388770.1 814577 R 5061 CDS An01g03400 84589886 join(815743..815802,815891..816418,816483..816623,816777..817553) II 1 NT_166518.1 Remark: alternative names for S. cerevisiae ARG81 are ARGR2 and YML099C.; Similarity: similarity is between the fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain containing N-terminal regions of the predicted A. niger protein and S. cerevisiae ARG81, which is 300 aa longer.; Similarity: the predicted A. niger protein contains a fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain.; Title: weak similarity to transcription factor Arg81 - Saccharomyces cerevisiae; nucleus; uncharacterized protein 817553 84589886 An01g03400 Aspergillus niger uncharacterized protein XP_059599573.1 815743 D 5061 CDS An01g03410 4978067 join(818338..818637,818718..819254,819324..819479) II 1 NT_166518.1 Function: S. cerevisiae Nfu1 has been implicated in mitochondrial Fe/S cluster assembly.; Function: mutations in S. cerevisiae nfu1 lead to decrease in activity of Fe/S containing mitochondrial proteins and mitochondrial iron accumulation.; Localization: S. cerevisiae Nfu1 is located in the mitochondrial matrix.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_2888 and 1706.; Remark: the systematic name for S. cerevisiae NFU1 is YKL040c.; Title: strong similarity to Fe/S cluster assembly factor Nfu1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 10468587; See PMID 11171977; uncharacterized protein 819479 4978067 An01g03410 Aspergillus niger uncharacterized protein XP_001388772.1 818338 D 5061 CDS An01g03430 84589887 join(821100..821107,821310..821652) II 1 NT_166518.1 hypothetical protein 821652 84589887 An01g03430 Aspergillus niger hypothetical protein XP_059599574.1 821100 D 5061 CDS An01g03440 84589888 join(823925..824040,824181..824307) II 1 NT_166518.1 Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 824307 84589888 An01g03440 Aspergillus niger uncharacterized protein XP_059599575.1 823925 D 5061 CDS An01g03450 4978126 join(827145..829291,829353..829875) II 1 NT_166518.1 Function: overepression of S. cerevisiae PSP1 suppresses the temperature sensitivity of mutations in DNA-Pol1, DNA-Pol3 and the DNA-replication initation factor CDC6.; Title: similarity to suppressor of DNA-Pol1 mutations Psp1 - Saccharomyces cerevisiae; See PMID 9529527; uncharacterized protein 829875 4978126 An01g03450 Aspergillus niger uncharacterized protein XP_059599576.1 827145 D 5061 CDS An01g03460 4978348 join(831046..831132,831358..831514,831575..831801,831876..832016) II 1 NT_166518.1 Gene-ID: rpl15; Remark: informations regarding A. niger rp115 has not yet been published and is available from Swissprot and EMBL.; Remark: the exon/intron structure of the predicted A. niger protein is in accordance with the A. niger EST an_1657.; Similarity: the aa sequences of A. niger rp115 and S. cerevisiae RPL15 are nearly identical.; cytoplasm; See PMID 6814480; 60S ribosomal protein eL15 832016 rpl15 4978348 rpl15 Aspergillus niger 60S ribosomal protein eL15 XP_001388776.1 831046 D 5061 CDS An01g03470 4977848 join(832907..833093,833153..835264,835327..836231) II 1 NT_166518.1 Function: human E6-AP is a ubiquitin-protein ligase (E3) implicated in p53 inactivation.; Title: strong similarity to ubiquitin protein ligase E6-AP - Homo sapiens; See PMID 8221889; See PMID 11265246; uncharacterized protein 836231 4977848 An01g03470 Aspergillus niger uncharacterized protein XP_001388777.3 832907 D 5061 CDS An01g03480 4978138 join(838062..838075,838136..838205,838280..838348,838413..838775,838831..839143,839200..839393) II 1 NT_166518.1 Catalytic activity: L-iditol 2-dehydrogenases convert L-iditol + NAD(+) to L-sorbose + NADH.; Remark: a splice site upstream of the start codon was detected.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_0571, 2665, 2264, 2244, 1618 and 0775.; Title: strong similarity to sorbitol dehydrogenase gutB - Bacillus subtilis; uncharacterized protein 839393 4978138 An01g03480 Aspergillus niger uncharacterized protein XP_001388778.3 838062 D 5061 CDS An01g03490 4978081 join(839882..840294,840368..840896) II 1 NT_166518.1 Title: strong similarity to hypothetical protein CAE76442.1 - Neurospora crassa; uncharacterized protein 840896 4978081 An01g03490 Aspergillus niger uncharacterized protein XP_059599577.1 839882 D 5061 CDS An01g03500 4978208 complement(join(840990..841666,841719..842146,842706..842866,842979..842990)) II 1 NT_166518.1 Remark: RZF of S. pombe is also called SPBC15C4. 06c.; Similarity: the ORF shows similarity to RZF only along a stretch of about 200 amino acids.; Similarity: the ORF shows strong similarity to the A. niger EST EMBLEST:BE760008 an_2963.; Similarity: the predicted A. niger protein contains a RING zinc finger DNA-binding motif and shows similarity to the RING zinc finger domains of several cDNAs.; Title: similarity to hypothetical serine-rich zinc-finger protein RZF - Schizosaccharomyces pombe; uncharacterized protein 842990 4978208 An01g03500 Aspergillus niger uncharacterized protein XP_059599578.1 840990 R 5061 CDS An01g03510 4978089 join(843556..844102,844206..844657,844700..845701) II 1 NT_166518.1 Complex: S. cerevisiae ADA3 is part of the ADA and SAGA histone acetyltransferase complexes which also contain Spt, Ada2, Gcn5 and, ADA specific, Ahc1.; Function: S. cerevisiae ADA3 is an adapter protein within the ADA and SAGA histone acetyltransferase complex.; Title: strong similarity to ADA and SAGA histone acetyltransferase subunint Ada3 - Saccharomyces cerevisiae; nucleus; See PMID 10490601; uncharacterized protein 845701 4978089 An01g03510 Aspergillus niger uncharacterized protein XP_059599579.1 843556 D 5061 CDS An01g03520 4978096 complement(join(846139..846787,847013..847218,847275..847459,847533..847907,847967..848009)) II 1 NT_166518.1 Function: it has been suggested that S. cerevisiae NPR2 is a post-transcriptional regulator of nitrogen permeases.; Regulation: S. cerevisiae NPR2 mRNA is not down-regulated under nitrogen catabolite repression, and is induced by urea and proline.; Title: similarity to nitrogen permease regulator Npr2 - Saccharomyces cerevisiae; See PMID 7867803; uncharacterized protein 848009 4978096 An01g03520 Aspergillus niger uncharacterized protein XP_059599580.1 846139 R 5061 CDS An01g03530 4978027 complement(848525..849439) II 1 NT_166518.1 hypothetical protein 849439 4978027 An01g03530 Aspergillus niger hypothetical protein XP_001388783.1 848525 R 5061 CDS An01g03540 4978087 join(850523..850649,850767..850791,851025..851242,851300..851328,851555..851653,851700..851853,851910..852178,852228..852812,852864..853973) II 1 NT_166518.1 Similarity: similarity is between the N-terminal regions of the predicted A. niger protein to human artemis.; Title: similarity to DNA double-strand break repair/V(D)J recombination protein artemis - Homo sapiens; See PMID 11336668; uncharacterized protein 853973 4978087 An01g03540 Aspergillus niger uncharacterized protein XP_059599581.1 850523 D 5061 CDS An01g03550 4978112 complement(join(854319..854588,854636..854695,854754..856811,856980..857066,857150..857170)) II 1 NT_166518.1 Catalytic activity: ureases convert urea + H(2)O to CO(2) + 2 NH(3).; Title: strong similarity to urease URE1 -Cryptococcus neoformans; See PMID 10639402; uncharacterized protein 857170 4978112 An01g03550 Aspergillus niger uncharacterized protein XP_059599582.1 854319 R 5061 CDS An01g03560 4978367 complement(join(858078..858093,858189..858628,858684..859070,859620..859700)) II 1 NT_166518.1 Complex: S. cerevisiae HMO1 binds single-stranded DNA and associates with a 5' to 3' DNA helicase activity.; Function: S. cerevisiae HMO1 is a single-stranded DNA binding protein that associates with a 5' to 3' DNA helicase activity in nuclear extracts.; Function: S. cerevisiae HMO1 may play a general role in controlling chromatin structure and perhaps a specific role in controlling transcription and DNA replication.; Remark: the coding region might be N-terminal truncated due to border of contig.; Remark: the systematic name for S. cerevisiae HMO1 is YDR174w.; Title: similarity to chromatin-associated protein Hmo1 - Saccharomyces cerevisiae; nucleus; See PMID 8969238; uncharacterized protein 859700 4978367 An01g03560 Aspergillus niger uncharacterized protein XP_059599583.1 858078 R 5061 CDS An01g03570 4978482 complement(join(860285..860853,860911..860985,861042..861321,861429..861473)) II 1 NT_166518.1 Catalytic activity: cytochrome-b5 reductases convert NADH + 2 ferricytochrome b5 to NAD(+) + 2 ferrocytochrome b5.; Function: S. cerevisiae MCR1 plays an important role in the response to oxidative damage.; Localization: S. cerevisiae MCR1 is inserted into the outer mitochondrial membrane, where 1/3 becomes firmely anchored at the outer surface while the rest is released into the intermembrane space after proteolytic cleavage in the inner membrane.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger EST an_2939.; Title: strong similarity to cytochrome-b5 reductase Mcr1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8001120; See PMID 11420140; uncharacterized protein 861473 4978482 An01g03570 Aspergillus niger uncharacterized protein XP_001388787.1 860285 R 5061 CDS An01g03580 4978127 complement(join(862745..862897,862960..863136,863209..863393,863770..863773,863838..863883,864074..864105)) II 1 NT_166518.1 Remark: alternative names for S. cerevisiae RPL20 are RPL18A2 and YMR242C.; Remark: the exon/intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_3214, 0548, 1747, 3000, 3600, 3406, 2063 and 0732.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L18a Rpl20 - Saccharomyces cerevisiae; cytoplasm; See PMID 9396790; See PMID 9421530; See PMID 10404161; 60S ribosomal protein eL20 864105 4978127 An01g03580 Aspergillus niger 60S ribosomal protein eL20 XP_001388788.3 862745 R 5061 CDS An01g03590 4978110 join(864244..864809,864860..865085,865141..865671,865727..865813) II 1 NT_166518.1 Title: strong similarity to peptidase HPEP-6 from patent WO200042201-A2 - Homo sapiens; uncharacterized protein 865813 4978110 An01g03590 Aspergillus niger uncharacterized protein XP_059599584.1 864244 D 5061 CDS An01g03600 4978108 complement(join(866265..866267,866520..866793,866869..867238,867384..867659,867756..867834)) II 1 NT_166518.1 Title: weak similarity to casein kinase 1 cki1p -Schizosaccharomyces pombe; uncharacterized protein 867834 4978108 An01g03600 Aspergillus niger uncharacterized protein XP_059599585.1 866265 R 5061 CDS An01g03610 4977934 complement(join(868090..868208,868370..868500,868709..868800,868987..869031,869090..869857,869916..870043,870114..870234)) II 1 NT_166518.1 Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_2008.; Title: strong similarity to hypothetical zf-C3HC4 zinc finger protein - Schizosaccharomyces pombe; uncharacterized protein 870234 4977934 An01g03610 Aspergillus niger uncharacterized protein XP_001388791.3 868090 R 5061 CDS An01g03620 84589889 complement(join(871912..872126,872282..872399,872452..872502,872593..872604)) II 1 NT_166518.1 hypothetical protein 872604 84589889 An01g03620 Aspergillus niger hypothetical protein XP_059599586.1 871912 R 5061 CDS An01g03630 4978115 join(872971..874249,874366..875537) II 1 NT_166518.1 Complex: S. cerevisiae STB1, STB2 and SIN3 are components of a large multiprotein complex.; Complex: in a two-hybrid screen S. cerevisiae STB2 binds the transcriptional repressor SIN3 which has no DNA binding activity.; Similarity: similarity is between the N-terminal halfs of the predicted A. niger protein and S. cerevisiae STB2.; Title: strong similarity to Sin3p binding protein Stb2 - Saccharomyces cerevisiae; nucleus; See PMID 9234741; See PMID 9393435; uncharacterized protein 875537 4978115 An01g03630 Aspergillus niger uncharacterized protein XP_059599587.1 872971 D 5061 CDS An01g03640 4977164 complement(join(875920..876103,876225..876322)) II 1 NT_166518.1 Complex: in S. cerevisiae the TIM10 complex can be formed exclusively from Tim9 and Tim10.; Complex: in S. cerevisiae the TIM10 complex is a member of the Tim18p-Tim22p-Tim54p membrane complex.; Function: the S. cerevisiae TIM10 complex functions as a putative chaperone to guide hydrophobic precursors across the intermembrane space.; Function: the S. cerevisiae TIM10 complex is a member of the Tim18p-Tim22p-Tim54p membrane complex that mediates precursor insertion into the membrane.; Function: the S. cerevisiae TIM10 complex is required for import of the ADP/ATP carrier (AAC) into mitochondria.; Localization: in S. cerevisiae the soluble TIM10 complex localises in the mitochondrial intermembrane space while as part of a larger complex it localises to the membrane.; Remark: an alternative name for S. cerevisiae TIM10 is MRS11.; Title: strong similarity to mitochondrial import factor Tim10 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 11483513; See PMID 11509656; uncharacterized protein 876322 4977164 An01g03640 Aspergillus niger uncharacterized protein XP_001388794.1 875920 R 5061 CDS An01g03650 4978137 join(876674..876732,876961..877250,877310..877474,877532..877957,878009..878826) II 1 NT_166518.1 Catalytic activity: lysine-tRNA ligase convert ATP + L-lysine + tRNA(Lys) to AMP + diphosphate + L-lysyl-tRNA(Lys).; Title: strong similarity to cytosolic lysine--tRNA ligase Krs1 - Saccharomyces cerevisiae; cytoplasm; See PMID 2903861; uncharacterized protein 878826 4978137 An01g03650 Aspergillus niger uncharacterized protein XP_001388795.3 876674 D 5061 CDS An01g03660 4978090 join(879331..879394,879508..880267,880371..880395) II 1 NT_166518.1 Similarity: the ORF shows strong similarity to EST 5419 - Aspergillus oryzae.; Title: similarity to hypothetical protein T9E8.140 -Arabidopsis thaliana; uncharacterized protein 880395 4978090 An01g03660 Aspergillus niger uncharacterized protein XP_059599588.1 879331 D 5061 CDS An01g03670 4977841 complement(join(880623..882541,882608..882883,883177..883369)) II 1 NT_166518.1 Similarity: the similarities are mainly due to repetetive sequences.; Title: strong similarity to hypothetical protein EAA66525.1 - Aspergillus nidulans; uncharacterized protein 883369 4977841 An01g03670 Aspergillus niger uncharacterized protein XP_059599589.1 880623 R 5061 CDS An01g03680 4977835 complement(883834..886290) II 1 NT_166518.1 Complex: mouse ALDR must form a homo- or heterodimer to be functional.; Similarity: mouse ALDR is a ABC half transporter containing one transmembrane domain and a single ATP-binding fold while functional ABC-tansporter comprise two transmembrane and two ATP-binding domains.; Title: strong similarity to peroxisomal ABC transporter ALDR - Mus musculus; peroxisome; See PMID 8577752; See PMID 10504404; uncharacterized protein 886290 4977835 An01g03680 Aspergillus niger uncharacterized protein XP_001388798.1 883834 R 5061 CDS An01g03690 84589890 complement(join(889031..889123,889219..889332,889420..889632,889678..889744,890192..890224,890338..890436,890759..890792,890889..891291)) II 1 NT_166518.1 Title: weak similarity to toxin subunit 1 TOX S1 -Bordetella pertussis; See PMID 2873570; uncharacterized protein 891291 84589890 An01g03690 Aspergillus niger uncharacterized protein XP_059599590.1 889031 R 5061 CDS An01g03700 4977286 join(891411..891510,891608..892803,892855..893004,893060..893158,893216..893428) II 1 NT_166518.1 Function: PSR1 of S. cerevisiae is a membrane-linked protein phosphatase involved in response to sodium stress,together with the homologue PSR2.; Phenotype: growth of the PSR1/PSR2 mutant is severely inhibited under conditions of sodium stress, due to the inability to properly induce transcription of ENA1/PMR2, the major sodium extrusion pump of yeast cells.; Remark: PSR1 of S. cerevisiae is also called YLL010c.; Similarity: the N-terminal region of the predicted ORF shows no significant similarity.; Title: strong similarity to phosphatase Psr1 -Saccharomyces cerevisiae; plasma membrane; See PMID 10777497; uncharacterized protein 893428 4977286 An01g03700 Aspergillus niger uncharacterized protein XP_001388800.1 891411 D 5061 CDS An01g03710 84589891 complement(join(893684..893850,893881..893938)) II 1 NT_166518.1 hypothetical protein 893938 84589891 An01g03710 Aspergillus niger hypothetical protein XP_059599591.1 893684 R 5061 CDS An01g03720 4978382 join(894763..894898,894993..895024,895101..895172,895242..895538,895595..895669,895738..896140,896201..896220) II 1 NT_166518.1 Function: SDS22 of S. cerevisiae is essential for the mitotic metaphase/anaphase transition, positively modulating protein phosphatase-1.; Remark: SDS22 of S. cerevisiae is also called EGP1 or YKL193c.; Title: strong similarity to protein phosphatase type1 regulatory subunit Sds22 - Saccharomyces cerevisiae; nucleus; See PMID 9584086; See PMID 10775415; See PMID 7791784; See PMID 7791785; uncharacterized protein 896220 4978382 An01g03720 Aspergillus niger uncharacterized protein XP_001388802.1 894763 D 5061 CDS An01g03730 4977073 complement(join(896438..896995,897070..897201)) II 1 NT_166518.1 Remark: the gene model was extracted to fill an intergenic region; the N-terminal part of the predicted ORF overlaps to the 3'UTR of the A. niger xyrA gene.; Title: questionable ORF; uncharacterized protein 897201 4977073 An01g03730 Aspergillus niger uncharacterized protein XP_001388803.1 896438 R 5061 CDS An01g03740 4977114 complement(join(897456..897482,897544..898331,898393..898537)) II 1 NT_166518.1 Function: D-xylose reductase catalyses the NADPH-dependent reduction of D-xylose to xylitol, which is the first step in D-xylose catabolism in fungi.; Gene-ID: xyrA; Induction: xyrA is under the transcriptional control of XlnR, a major transcription factor involved in the degradation of the polysaccharides xylan and cellulose.; See PMID 10760176; D-xylose reductase xyrA-Aspergillus niger 898537 xyrA 4977114 xyrA Aspergillus niger D-xylose reductase xyrA-Aspergillus niger XP_001388804.3 897456 R 5061 CDS An01g03750 4978477 complement(join(899081..900828,900885..901061,901115..901553)) II 1 NT_166518.1 Function: A. nidulans brlA, abaA, and wetA form a dependent pathway that regulates asexual reproductive development.; Function: in A. nidulans, expression of abaA in vegetative cells does not result in conidial differentiation but does lead to activation of brlA and wetA, cessation of vegetative growth, and accentuated cellular vacuolization.; Title: strong similarity to protein abaA -Aspergillus nidulans; See PMID 2655931; uncharacterized protein 901553 4978477 An01g03750 Aspergillus niger uncharacterized protein XP_001388805.1 899081 R 5061 CDS An01g03760 4978174 complement(join(902537..903754,903805..904077,904290..905048,905144..905371)) II 1 NT_166518.1 Similarity: the presence of RNA binding domains suggests a role in RNA processing.; Title: strong similarity to hypothetical protein pi029 - Schizosaccharomyces pombe; uncharacterized protein 905371 4978174 An01g03760 Aspergillus niger uncharacterized protein XP_001388806.1 902537 R 5061 CDS An01g03770 4977654 join(905661..905691,905743..905765,905816..905849,905903..905937,905983..906009,906062..906131,906181..906245) II 1 NT_166518.1 Complex: dynein consists of at least two heavy chains and a number of intermediate and light chains.; Function: dynein is involved in intracellular transport and motility, and plays a role in changing or maintaining the spatial distribution of cytoskeletal structures.; Similarity: the predicted ORF is almost identical to the 8 kDa cytoplasmic dynein light chain NUDG of Aspergillus nidulans, whose characterization has not been published.; Title: strong similarity to dynein light chain 1 cdlc1 - Drosophila melanogaster; See PMID 8628263; See PMID 11212346; uncharacterized protein 906245 4977654 An01g03770 Aspergillus niger uncharacterized protein XP_001388807.1 905661 D 5061 CDS An01g03780 4977914 join(906588..906885,907186..907219,907295..907319,907377..907409,907475..907515,907584..907776) II 1 NT_166518.1 Similarity: the patented EST covers the last two exons and part of the putative 3'-UTR.; Title: strong similarity to EST SEQ ID NO:4125 from patent WO200056762-A2 - Aspergillus niger; uncharacterized protein 907776 4977914 An01g03780 Aspergillus niger uncharacterized protein XP_059599592.1 906588 D 5061 CDS An01g03790 4978170 complement(join(908116..908692,908748..909401,909455..909971,910025..910197,910281..910402)) II 1 NT_166518.1 Function: DUR3 is a component required for active transport of urea in S. cerevisiae.; Similarity: DUR3 of S. cerevisiae is a member of the major facilitator superfamily (MFS) of transport proteins.; Title: strong similarity to urea transport protein Dur3 - Saccharomyces cerevisiae; plasma membrane; See PMID 7867803; See PMID 8335627; See PMID 8720066; uncharacterized protein 910402 4978170 An01g03790 Aspergillus niger uncharacterized protein XP_001388809.1 908116 R 5061 CDS An01g03800 84589892 join(910576..910662,910827..911120,911202..911258) II 1 NT_166518.1 hypothetical protein 911258 84589892 An01g03800 Aspergillus niger hypothetical protein XP_059599593.1 910576 D 5061 CDS An01g03810 4977053 911778..912692 II 1 NT_166518.1 Similarity: the HIT (histidine triad) region binds one zinc ion in proteins lacking zinc fingers; the domain is poorly conserved in the predicted ORF.; Similarity: the N-terminal part of the predicted protein produces some BLASTP hits due to the high content of low-complexity regions.; Title: similarity to hypothetical HIT-like protein -Rhodococcus sp.; uncharacterized protein 912692 4977053 An01g03810 Aspergillus niger uncharacterized protein XP_001388811.1 911778 D 5061 CDS An01g03820 4977591 complement(join(913162..913196,913258..913603,913743..913745)) II 1 NT_166518.1 Complex: SBH2 of cerevisiae interacts with SSH1 and SSS1; the complex is involved in protein translocation into the endoplasmic reticulum.; Remark: SBH2 of S. cerevisiae is also known as SEB2 or YER019C.; Similarity: strong similarity to A. oryzae EST PATENTDNA:AAF12808, which confirms the structure of exons 2 and 3.; Title: strong similarity to ER protein-translocation complex subunit Sbh2 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 8612571; See PMID 8740416; See PMID 10921929; uncharacterized protein 913745 4977591 An01g03820 Aspergillus niger uncharacterized protein XP_001388812.1 913162 R 5061 CDS An01g03840 84589893 complement(join(914167..914320,914422..914539,914652..914848,915057..915097)) II 1 NT_166518.1 hypothetical protein 915097 84589893 An01g03840 Aspergillus niger hypothetical protein XP_059599594.1 914167 R 5061 CDS An01g03850 84589894 join(915404..915443,915645..915690,915734..915908,916010..916060) II 1 NT_166518.1 hypothetical protein 916060 84589894 An01g03850 Aspergillus niger hypothetical protein XP_059599595.1 915404 D 5061 CDS An01g03860 84589895 complement(join(916898..917019,917118..917245,917378..917464,917509..917586,917669..917715)) II 1 NT_166518.1 hypothetical protein 917715 84589895 An01g03860 Aspergillus niger hypothetical protein XP_059599596.1 916898 R 5061 CDS An01g03870 4978308 join(918028..918110,918180..918618,918671..918865,918920..919210) II 1 NT_166518.1 Title: strong similarity to hypothetical protein SPAC23H3.04 - Schizosaccharomyces pombe; uncharacterized protein 919210 4978308 An01g03870 Aspergillus niger uncharacterized protein XP_001388816.1 918028 D 5061 CDS An01g03880 84589896 919462..919611 II 1 NT_166518.1 Title: strong similarity to EST an_1234 -Aspergillus niger; uncharacterized protein 919611 84589896 An01g03880 Aspergillus niger uncharacterized protein XP_059599597.1 919462 D 5061 CDS An01g03900 4977098 complement(join(920827..922080,922328..925138)) II 1 NT_166518.1 Function: AtrA of A. nidulans is an ABC transporter,and can complement the drug hypersensitivity associated with PDR5 deficiency in S. cerevisiae.; Function: multidrug transporters are membrane proteins which, by an unknown mechanism, recognize diverse toxic compounds and efflux them from cells.; Title: strong similarity to ATP-binding cassette multidrug transport protein atrA - Aspergillus nidulans; plasma membrane; See PMID 9180695; uncharacterized protein 925138 4977098 An01g03900 Aspergillus niger uncharacterized protein XP_059599598.1 920827 R 5061 CDS An01g03910 84589897 complement(join(926033..926182,926270..926482)) II 1 NT_166518.1 hypothetical protein 926482 84589897 An01g03910 Aspergillus niger hypothetical protein XP_059599599.1 926033 R 5061 CDS An01g03920 84589898 join(926586..926709,926933..926998,927195..927263,927341..927447) II 1 NT_166518.1 hypothetical protein 927447 84589898 An01g03920 Aspergillus niger hypothetical protein XP_059599600.1 926586 D 5061 CDS An01g03930 84589899 complement(join(928678..928695,928752..929038,929092..929521,929590..929630,929684..929890,930307..930322)) II 1 NT_166518.1 Function: pcn1 of S. pombe is involved in nucleic acid metabolism and cell-cycle control.; Function: pcn1 of S. pombe seems to encircle DNA and tether the polymerase to the DNA template for processive DNA synthesis.; Title: strong similarity to proliferating cell nuclear antigen pcn1p - Schizosaccharomyces pombe; nucleus; See PMID 10449724; See PMID 1361173; uncharacterized protein 930322 84589899 An01g03930 Aspergillus niger uncharacterized protein XP_059599601.1 928678 R 5061 CDS An01g03940 84589900 join(930778..930794,930868..930907,930951..931074,931133..931296,931339..931468,931533..932035) II 1 NT_166518.1 Title: strong similarity to hypothetical protein EAA64320.1 - Aspergillus nidulans; uncharacterized protein 932035 84589900 An01g03940 Aspergillus niger uncharacterized protein XP_059599602.1 930778 D 5061 CDS An01g03950 4978203 complement(join(932684..933348,933400..933851,933907..934388,934450..934649,934711..934759)) II 1 NT_166518.1 Title: strong similarity to hypothetical protein CAE76289.1 - Neurospora crassa; uncharacterized protein 934759 4978203 An01g03950 Aspergillus niger uncharacterized protein XP_059599603.1 932684 R 5061 CDS An01g03960 84589901 complement(join(935166..935322,935412..935610,935655..935718)) II 1 NT_166518.1 Title: weak similarity to hypothetical kinesin-like protein klp-7 - Caenorhabditis elegans; uncharacterized protein 935718 84589901 An01g03960 Aspergillus niger uncharacterized protein XP_059599604.1 935166 R 5061 CDS An01g03970 4977029 join(936758..938787,938833..939688) II 1 NT_166518.1 Similarity: the C-terminal part shows strong similarity to D. melanogaster asp, mammalian plectins and dystonin, all proteins involved in cytoskeletal organization, in different cellular compartments and functional contexts.; Similarity: the N-terminal part shows a weaker similarity to X. laevis nucleolar phosphoprotein xNopp180,involved in nuclear localization signal binding, which shuttles between the nucleolus and the cytoplasm.; Similarity: the predicted protein shows different similarities in the N-terminal and C-terminal halves.; Title: similarity to microtubule-associated protein asp - Drosophila melanogaster; See PMID 9151690; See PMID 7593294; uncharacterized protein 939688 4977029 An01g03970 Aspergillus niger uncharacterized protein XP_059599605.1 936758 D 5061 CDS An01g03980 84589902 complement(join(940144..940215,940276..940284,940339..940376,940610..940643,940747..940767,940824..940829)) II 1 NT_166518.1 Title: questionable ORF; uncharacterized protein 940829 84589902 An01g03980 Aspergillus niger uncharacterized protein XP_059599606.1 940144 R 5061 CDS An01g03990 84589903 complement(join(941425..941491,941548..941661,941718..941874,941956..941989,942062..942110,942203..942318)) II 1 NT_166518.1 Similarity: very weak similarity to a putative protein kinase of Myxococcus xanthus, that has a totally different length.; hypothetical protein 942318 84589903 An01g03990 Aspergillus niger hypothetical protein XP_059599607.1 941425 R 5061 CDS An01g04000 84589904 join(942391..942721,942772..942830) II 1 NT_166518.1 hypothetical protein 942830 84589904 An01g04000 Aspergillus niger hypothetical protein XP_059599608.1 942391 D 5061 CDS An01g04010 84589905 complement(join(943098..943144,943311..943434)) II 1 NT_166518.1 Title: weak similarity to protein fragment SEQ ID NO:5110 from patent EP1033405-A2 - Zea mays; uncharacterized protein 943434 84589905 An01g04010 Aspergillus niger uncharacterized protein XP_059599609.1 943098 R 5061 CDS An01g04020 84589906 complement(join(944542..944768,945181..945440,945543..945640,945809..945907,946010..946069,946434..946496,946712..946865,946910..946965,947207..947323,947566..947733,947999..948129,948222..948467,948647..948730,948985..949125,949208..949268)) II 1 NT_166518.1 hypothetical protein 949268 84589906 An01g04020 Aspergillus niger hypothetical protein XP_059599610.1 944542 R 5061 CDS An01g04030 4977200 949555..951666 II 1 NT_166518.1 Similarity: the inner part of the predicted ORF shows some similarity to the C-terminal half of the hypothetical protein SPCC1259. 08 of S. pombe.; Title: weak similarity to hypothetical protein SPCC1259.08 - Schizosaccharomyces pombe; uncharacterized protein 951666 4977200 An01g04030 Aspergillus niger uncharacterized protein XP_001388831.3 949555 D 5061 CDS An01g04040 4977273 join(952476..952494,952653..952756,952920..952959,953062..953127,953203..953502,953567..953607) II 1 NT_166518.1 Function: sarA of A. nidulans is involved in the secretion of proteins, probably as a component of COPII coat of vesicles, that facilitate the transport from the ER to the Golgi by vesicle budding.; Gene-ID: sarA; Phenotype: three mutant alleles of the A. niger sarA gene (D29G, E109K, D29G/E109K), generated by site-directed mutagenesis, revealed a thermosensitive dominant-negative phenotype in the presence of the wild-type sarA allele.; Similarity: the sequence of the predicted ORF is different to the published translation of the A. niger sarA gene at positions C102R, D141E and V142L.; See PMID 8889833; See PMID 9756629; secretion-associated GTP-binding protein sarA-Aspergillus niger 953607 sarA 4977273 sarA Aspergillus niger secretion-associated GTP-binding protein sarA-Aspergillus niger XP_001388832.1 952476 D 5061 CDS An01g04050 4978130 complement(join(955646..955741,955820..>956119)) II 1 NT_166518.1 Function: bimG of A. nidulans is required for the completion of anaphase by reversing the action of the nimA kinase.; Phenotype: a mutation in bimG of A. nidulans causes an abnormally high content of nuclear phosphoproteins.; Phenotype: the temperature-sensitive, recessive cell cycle mutation A. nidulans bimG11 causes an elevated mitotic index at restrictive temperature and an inability to complete the anaphase separation of daughter nuclei.; Remark: the N-terminal part of the ORF is found on ORF An01g04060.; Remark: the ORF is N-terminally truncated due to contig border.; Title: strong similarity to phosphoprotein phosphatase bimG - Aspergillus nidulans [truncated ORF]; uncharacterized protein 956119 4978130 An01g04050 Aspergillus niger uncharacterized protein XP_001388833.3 955646 R 5061 CDS An01g04060 4977148 complement(join(956837..957717,957769..957984,958034..958874,958923..959937,960021..960289)) II 1 NT_166518.1 Function: TFC4 of S. cerevisiae is a subunit of transcription factor tau (TFIIIC) involved in tRNA and 5SRNA gene transcription; TFC4 acts as assembly factor,which recruits the initiation factor, TFIIIB, to the DNA.; Remark: TFC4 of S. cerevisiae is also called YGR047C or pcf1.; Title: strong similarity to assembling subunit of transcription factor IIIC Tfc4 - Saccharomyces cerevisiae; nucleus; See PMID 2686985; uncharacterized protein 960289 4977148 An01g04060 Aspergillus niger uncharacterized protein XP_059599611.1 956837 R 5061 CDS An01g04070 84589907 complement(join(960827..960935,961033..961112)) II 1 NT_166518.1 Remark: the predicted ORF is only 62 amino acids long.; Title: questionable ORF; uncharacterized protein 961112 84589907 An01g04070 Aspergillus niger uncharacterized protein XP_059599612.1 960827 R 5061 CDS An01g04080 4977292 join(961990..962491,962550..963832,963887..963943) II 1 NT_166518.1 Similarity: the similarity of the predicted ORF to the hypothetical protein YOR359w of S. cerevisiae is restricted to the C-terminal end of both proteins, but the homology in this region is relatively high.; Title: similarity to hypothetical protein YOR359w -Saccharomyces cerevisiae; uncharacterized protein 963943 4977292 An01g04080 Aspergillus niger uncharacterized protein XP_001388836.1 961990 D 5061 CDS An01g04090 84589908 join(964270..964278,964378..965058) II 1 NT_166518.1 hypothetical protein 965058 84589908 An01g04090 Aspergillus niger hypothetical protein XP_059599613.1 964270 D 5061 CDS An01g04100 4977465 complement(join(965215..965316,965376..965995,966063..966119,966223..966619,966666..966701,966750..966762,966815..967154,967214..967544)) II 1 NT_166518.1 Function: mdr of B. subtilis is a multidrug-efflux transporter for e. g. puromycin, nerfloxacin and tosufloxa.; Similarity: the ORF shows strong similarity to several multidrug-efflux transporters (especially from bacteria) with different specificities.; Title: strong similarity to multidrug resistance protein MDR - Bacillus subtilis; See PMID 1675788; See PMID 11378963; uncharacterized protein 967544 4977465 An01g04100 Aspergillus niger uncharacterized protein XP_059599614.1 965215 R 5061 CDS An01g04110 4977419 complement(968260..>969306) II 1 NT_166518.1 Function: SutB of P. chrysogenum is the major sulfate permease involved in sulfate uptake by P. chrysogenum.; Function: in industrial fermentations, P. chrysogenum uses sulfate as the source of sulfur for the biosynthesis of penicillin.; Phenotype: disruption of P. chrysogenum sutB resulted in a loss of sulfate uptake ability.; Remark: the N-terminal half of the homolog to SutB of P. chrysogenum is located in ORF An01g04210.; Remark: the ORF is N-terminally truncated due to contig border.; Title: strong similarity to sulfate permease SutB -Penicillium chrysogenum [truncated ORF]; uncharacterized protein 969306 4977419 An01g04110 Aspergillus niger uncharacterized protein XP_001388839.3 968260 R 5061 CDS An01g04120 4977628 complement(join(<969574..969975,970065..970241)) II 1 NT_166518.1 Function: bimG of A. nidulans is required for the completion of anaphase by reversing the action of the nimA kinase.; Phenotype: a mutation in bimG of A. nidulans causes an abnormally high content of nuclear phosphoproteins.; Phenotype: the temperature-sensitive, recessive cell cycle mutation A. nidulans bimG11 causes an elevated mitotic index at restrictive temperature and an inability to complete the anaphase separation of daughter nuclei.; Remark: the C-terminal part of the ORF is found on ORF An01g04050.; Remark: the ORF is C-terminally truncated due to contig border.; Title: strong similarity to phosphoprotein phosphatase bimG - Aspergillus nidulans [truncated ORF]; uncharacterized protein 970241 4977628 An01g04120 Aspergillus niger uncharacterized protein XP_001388840.3 969574 R 5061 CDS An01g04130 84589909 join(970825..971096,971182..971228,971328..971443) II 1 NT_166518.1 hypothetical protein 971443 84589909 An01g04130 Aspergillus niger hypothetical protein XP_059599615.1 970825 D 5061 CDS An01g04140 84589910 complement(972516..972671) II 1 NT_166518.1 Remark: the EST of A. niger can be found in EMBLEST:BE759969.; Similarity: the alignment of the predicted ORF sequence with the A. niger EST shows some gaps and missmatches.; Title: similarity to EST an_2919 - Aspergillus niger; uncharacterized protein 972671 84589910 An01g04140 Aspergillus niger uncharacterized protein XP_059599616.1 972516 R 5061 CDS An01g04150 4977906 complement(join(973359..974806,974920..975739,975837..975878)) II 1 NT_166518.1 Similarity: the predicted ORF is 148 amino acids longer than the hypothetical protein SPAC926. 06c of S. pombe.; Title: strong similarity to hypothetical protein SPAC926.06c - Schizosaccharomyces pombe; uncharacterized protein 975878 4977906 An01g04150 Aspergillus niger uncharacterized protein XP_001388843.3 973359 R 5061 CDS An01g04160 84589911 complement(join(977295..977439,977483..977629,977687..977776,977976..978100,978348..978360,978667..978670,978726..978795)) II 1 NT_166518.1 Remark: the intron-exon structure for the predicted ORF is suboptimal.; hypothetical protein 978795 84589911 An01g04160 Aspergillus niger hypothetical protein XP_059599617.1 977295 R 5061 CDS An01g04170 84589912 join(979942..980039,980067..980113,980277..980446,980519..980637,980774..980878,981078..981161,981269..981334,981613..981894,982008..982085,982393..982492) II 1 NT_166518.1 Remark: the predicted intron-exon structure of the ORF is not optimal.; hypothetical protein 982492 84589912 An01g04170 Aspergillus niger hypothetical protein XP_059599618.1 979942 D 5061 CDS An01g04180 4978123 join(982925..984364,984431..985240) II 1 NT_166518.1 Similarity: the ORF overlaps with A. niger EST (EMBLEST:BE759732) an_2635.; Similarity: the predicted ORF is 119 amino acids longer than the hypothetical protein SPAC31G5. 20c of S. pombe.; Title: strong similarity to hypothetical protein SPAC31G5.20c - Schizosaccharomyces pombe; uncharacterized protein 985240 4978123 An01g04180 Aspergillus niger uncharacterized protein XP_001388846.1 982925 D 5061 CDS An01g04190 84589913 complement(986246..986410) II 1 NT_166518.1 Remark: the predicted ORF is only 54 amino acids long.; Title: questionable ORF; uncharacterized protein 986410 84589913 An01g04190 Aspergillus niger uncharacterized protein XP_059599619.1 986246 R 5061 CDS An01g04200 84589914 join(987020..987040,987079..987150) II 1 NT_166518.1 Remark: the predicted ORF is only 30 amino acids long.; Title: questionable ORF; uncharacterized protein 987150 84589914 An01g04200 Aspergillus niger uncharacterized protein XP_059599620.1 987020 D 5061 CDS An01g04210 4978187 complement(join(<987637..988073,988141..988684,988748..988893,988964..989264)) II 1 NT_166518.1 Function: SutB of P. chrysogenum is the major sulfate permease involved in sulfate uptake by P. chrysogenum.; Function: in industrial fermentations, P. chrysogenum uses sulfate as the source of sulfur for the biosynthesis of penicillin.; Phenotype: disruption of P. chrysogenum sutB resulted in a loss of sulfate uptake ability.; Remark: the C-terminal half of the homolog to SutB of P. chrysogenum is located on An01g04200.; Remark: the ORF is C-terminally truncated due to contig border.; Title: strong similarity to sulfate permease SutB -Penicillium chrysogenum [truncated ORF]; uncharacterized protein 989264 4978187 An01g04210 Aspergillus niger uncharacterized protein XP_001388849.3 987637 R 5061 CDS An01g04220 84589915 join(991205..991284,991325..991591,991808..991944,992030..992262) II 1 NT_166518.1 hypothetical protein 992262 84589915 An01g04220 Aspergillus niger hypothetical protein XP_059599621.1 991205 D 5061 CDS An01g04230 4978154 complement(join(993587..993977,994039..994707,994769..995154)) II 1 NT_166518.1 Title: strong similarity to hypothetical WD-repeat transcription regulation protein SPCC18.13 -Schizosaccharomyces pombe; uncharacterized protein 995154 4978154 An01g04230 Aspergillus niger uncharacterized protein XP_001388851.1 993587 R 5061 CDS An01g04240 4977317 join(995490..995663,995721..995790,995855..996549) II 1 NT_166518.1 Remark: P0 of S. cerevisiae belongs to the family of rat acidic ribosomal proteins P0.; Remark: P0 of S. cerevisiae is also called A0,L8300. 8, YLR340w and ribosomal protein YL10e.; Similarity: the ORF overlaps with the EST seq id NO:3822 of patent WO200056762-A2 from A. niger.; Title: strong similarity to cytoplasmic acidic ribosomal protein P0 - Saccharomyces cerevisiae; cytoplasm; See PMID 2681177; See PMID 3287327; 60S ribosomal protein uL10 996549 4977317 An01g04240 Aspergillus niger 60S ribosomal protein uL10 XP_001388852.1 995490 D 5061 CDS An01g04250 4978301 join(997368..997422,997478..997519,997618..998541,998591..998661) II 1 NT_166518.1 Catalytic activity: Uroporphyrinogen-III <=> coproporphyrinogen + 4 CO(2).; Function: the T. terrestris homolog catalyzes the sequential decarboxylation of the four acetyl side chains of uroporphyrinogen to yield coproporphyrinogen, an intermediate in protoheme biosynthesis.; Title: strong similarity to uroporphyrinogen decarboxylase from patent WO9925839-A1 - Thielavia terrestris; cytoplasm; uncharacterized protein 998661 4978301 An01g04250 Aspergillus niger uncharacterized protein XP_001388853.1 997368 D 5061 CDS An01g04260 4978191 complement(join(998761..998782,998860..999125,999195..999353)) II 1 NT_166518.1 Catalytic activity: cytosine + H(2)O <=> uracil + NH(3).; Remark: strong similarity to cytosine deaminase FCA1 - Candida albicans.; Title: strong similarity to cytosine deaminase FCA1 - Candida albicans; See PMID 9000374; uncharacterized protein 999353 4978191 An01g04260 Aspergillus niger uncharacterized protein XP_001388854.1 998761 R 5061 CDS An01g04270 84589916 complement(join(999446..999511,999940..1000137,1000683..1000824,1000923..1001103,1001208..1001293,1001340..1001377)) II 1 NT_166518.1 Title: similarity to EST SEQ ID NO:4107 from patent WO200056762-A2 - Aspergillus niger; uncharacterized protein 1001377 84589916 An01g04270 Aspergillus niger uncharacterized protein XP_059599622.1 999446 R 5061 CDS An01g04280 4977506 join(1001523..1001558,1001628..1001697,1001775..1002593,1002654..1002970) II 1 NT_166518.1 Function: Haploid S. cerevisiae cells carrying the disrupted YDJ1 gene are inviable for growth in liquid media.; Function: YDJ1p from S. cerevisiae is involved mitochondrial and ER import.; Function: YDJ1p from S. cerevisiae is required for normal growth and disruption of its gene results in very slow growing cells that have pleiotropic morphological defects.; Localization: YDJ1p from S. cerevisiae cofractionates with nuclei and also microsomes, suggesting that its perinuclear localization reflects association with the ER.; Remark: has similarity to family of dnaJ heat shock proteins.; Remark: synonyms for Ydj1 from S. cerevisiae are Mas5 and YNL064c.; Similarity: the ORF also shows strong similarity to expressed sequence tag seq id no:6895 of patent WO200056762-A2 from Aspergillus oryzae.; Title: strong similarity to dnaJ protein homolog Ydj1 - Saccharomyces cerevisiae; cytoplasm; See PMID 11014801; See PMID 11689685; uncharacterized protein 1002970 4977506 An01g04280 Aspergillus niger uncharacterized protein XP_001388856.1 1001523 D 5061 CDS An01g04300 4978441 complement(join(1004347..1005078,1005138..1006930,1006993..1007071)) II 1 NT_166518.1 Title: strong similarity to protein fragment SEQ ID NO:54638 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 1007071 4978441 An01g04300 Aspergillus niger uncharacterized protein XP_001388857.1 1004347 R 5061 CDS An01g04310 4977289 complement(join(1007842..1007889,1007944..1009449)) II 1 NT_166518.1 Function: the S. pombe homolog Mex67p participates at various common steps with Rae1p export complexes in promoting the nuclear cytoplasmic export of mRNA.; Similarity: S. pombe Mex67p has similarity to the human mRNA export factor Tap.; Title: strong similarity to mRNA export factor mex67p - Schizosaccharomyces pombe; nucleus; uncharacterized protein 1009449 4977289 An01g04310 Aspergillus niger uncharacterized protein XP_001388858.3 1007842 R 5061 CDS An01g04320 4978356 join(1010990..1011182,1011250..1011430,1011513..1012064,1012143..1012437) II 1 NT_166518.1 Complex: part of the Erv41p-Erv46p subcomplex associated with the COPII vesicle coat.; Function: S. cerevisiae Erv46p is involved in ER to Golgi vesicle transport.; Remark: a splice site upstream of the start codon was detected.; Remark: alternative gene names for the S. cerevisiae homolog ERV46 are FUN9 and YAL042W.; Title: strong similarity to COPII vesicle coat component protein Erv46 - Saccharomyces cerevisiae; intracellular transport vesicles; uncharacterized protein 1012437 4978356 An01g04320 Aspergillus niger uncharacterized protein XP_059599623.1 1010990 D 5061 CDS An01g04330 4978479 complement(join(1013493..1016486,1016551..1016708,1016768..1017118,1017196..1017211)) II 1 NT_166518.1 Title: strong similarity to hypothetical protein YLR187w - Saccharomyces cerevisiae; uncharacterized protein 1017211 4978479 An01g04330 Aspergillus niger uncharacterized protein XP_001388860.1 1013493 R 5061 CDS An01g04340 84589917 join(1017660..1017732,1017816..1017973,1018056..1018172) II 1 NT_166518.1 hypothetical protein 1018172 84589917 An01g04340 Aspergillus niger hypothetical protein XP_059599624.1 1017660 D 5061 CDS An01g04350 84589918 complement(join(1018718..1018775,1019096..1019320,1019403..1019510,1019609..1019719,1019900..1020055,1020142..1020182,1020277..1020390,1020571..1020636,1020722..1020874)) II 1 NT_166518.1 hypothetical protein 1020874 84589918 An01g04350 Aspergillus niger hypothetical protein XP_059599625.1 1018718 R 5061 CDS An01g04360 4977080 join(1022402..1023005,1023062..1023828) II 1 NT_166518.1 hypothetical protein 1023828 4977080 An01g04360 Aspergillus niger hypothetical protein XP_001388863.3 1022402 D 5061 CDS An01g04370 4977330 complement(1025298..1026836) II 1 NT_166518.1 Function: the C. albicans homolog CATFIIIA is involved in initiating transcription of the ribosomal RNA 5S gene.; Similarity: C. abicans CATFIIIA belongs to the superfamily of transcription factor IIIA proteins.; Title: strong similarity to transcription factor CATFIIIA from patent WO200028037-A1 - Candida albicans; nucleus; uncharacterized protein 1026836 4977330 An01g04370 Aspergillus niger uncharacterized protein XP_001388864.3 1025298 R 5061 CDS An01g04380 4978285 join(1027426..1027460,1027589..1027882,1027955..1028074,1028146..1028179) II 1 NT_166518.1 Complex: S. cerevisiae Rpo26p is essential for the assembly of RNA polymerase I and RNA polymerase II and for the stability of the largest subunits of these enzymes.; Function: the S. cerevisiae homolog RPO26 catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.; Title: strong similarity to 23 kD subunit of DNA-directed RNA polymerase I,II,III Rpo26 - Saccharomyces cerevisiae; nucleus; uncharacterized protein 1028179 4978285 An01g04380 Aspergillus niger uncharacterized protein XP_001388865.1 1027426 D 5061 CDS An01g04390 84589919 join(1028410..1028549,1028641..1028715,1028928..1028974,1029311..1029592,1029720..1029792,1029923..1030274) II 1 NT_166518.1 hypothetical protein 1030274 84589919 An01g04390 Aspergillus niger hypothetical protein XP_059599626.1 1028410 D 5061 CDS An01g04400 4977131 join(1030556..1030740,1030803..1031931) II 1 NT_166518.1 Similarity: has similarity to the monocarboxylate transporters of the major facilitator superfamily.; Title: strong similarity to hypothetical protease Mch5 - Saccharomyces cerevisiae; uncharacterized protein 1031931 4977131 An01g04400 Aspergillus niger uncharacterized protein XP_001388867.1 1030556 D 5061 CDS An01g04410 4978222 complement(join(1032539..1032710,1032838..1033069,1033154..1033322)) II 1 NT_166518.1 Title: strong similarity to N-acetyl transferase NACTH from patent US6017744-A - Homo sapiens; uncharacterized protein 1033322 4978222 An01g04410 Aspergillus niger uncharacterized protein XP_001388868.1 1032539 R 5061 CDS An01g04420 4977768 join(1033917..1034638,1034728..1035301) II 1 NT_166518.1 Title: strong similarity to hypothetical protein CAE76116.1 - Neurospora crassa; uncharacterized protein 1035301 4977768 An01g04420 Aspergillus niger uncharacterized protein XP_001388869.1 1033917 D 5061 CDS An01g04430 4977231 complement(join(1036821..1037337,1037412..1039786,1039869..1040093,1040224..1040265)) II 1 NT_166518.1 Title: strong similarity to translation initiation factor eIF-3 - Schizosaccharomyces pombe; cytoplasm; uncharacterized protein 1040265 4977231 An01g04430 Aspergillus niger uncharacterized protein XP_001388870.1 1036821 R 5061 CDS An01g04440 4977138 join(1043357..1043428,1043560..1043629,1043717..1043788,1043878..1044089) II 1 NT_166518.1 Similarity: the C-terminal region of the predicted protein shows no similarity.; Title: strong similarity to hypothetical conserved protein SMc00345 - Sinorhizobium meliloti; uncharacterized protein 1044089 4977138 An01g04440 Aspergillus niger uncharacterized protein XP_059599627.1 1043357 D 5061 CDS An01g04450 4977678 complement(join(1044657..1046644,1046711..1047716)) II 1 NT_166518.1 Catalytic activity: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.; Function: PDE9A of M. musculus and H. sapiens plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides; this phosphodiesterase has a high affinity for cGMP.; Remark: in mammals a number of isoforms of PDE9A are produced by alternative splicing.; Similarity: the predicted protein is almost twice longer as PDE9A of mammals, and the N- and C-terminal regions show no similarity.; Title: similarity to cGMP phosphodiesterase PDE9A -Mus musculus; See PMID 9624145; See PMID 9856478; uncharacterized protein 1047716 4977678 An01g04450 Aspergillus niger uncharacterized protein XP_001388872.3 1044657 R 5061 CDS An01g04455 84589920 complement(join(1047772..1048021,1048441..1048508,1048625..1048657)) II 1 NT_166518.1 hypothetical protein 1048657 84589920 An01g04455 Aspergillus niger hypothetical protein XP_059599628.1 1047772 R 5061 CDS An01g04460 84589921 join(1048867..1048879,1049019..1049216,1049355..1049471,1049745..1049794,1050012..1050128) II 1 NT_166518.1 hypothetical protein 1050128 84589921 An01g04460 Aspergillus niger hypothetical protein XP_059599629.1 1048867 D 5061 CDS An01g04470 4977831 complement(1054041..1057907) II 1 NT_166518.1 Similarity: although some regions of the predicted protein are very similar to S. pombe SPAC3H1. 12c, other regions are absolutely not conserved.; Similarity: the predicted protein contains several structurale domains found in DNA-binding regulatory proteins, like the BAH domain, the PHD-type zinc finger and the Myb-like DNA-binding domain.; Title: similarity to hypothetical protein YGL131c -Saccharomyces cerevisiae; uncharacterized protein 1057907 4977831 An01g04470 Aspergillus niger uncharacterized protein XP_059599630.1 1054041 R 5061 CDS An01g04480 84589922 join(1059468..1059627,1059804..1059909,1059980..1060123,1060216..1060398,1060480..1060544,1060643..1060697,1060777..1060905,1061076..1061181,1061357..1061434) II 1 NT_166518.1 Title: weak similarity to gravin-like gl - Xenopus laevis; See PMID 11165490; uncharacterized protein 1061434 84589922 An01g04480 Aspergillus niger uncharacterized protein XP_059599631.1 1059468 D 5061 CDS An01g04490 84589923 complement(join(1062262..1062398,1062648..1062897)) II 1 NT_166518.1 hypothetical protein 1062897 84589923 An01g04490 Aspergillus niger hypothetical protein XP_059599632.1 1062262 R 5061 CDS An01g04500 84589924 complement(join(1063262..1063481,1063764..1063916,1063989..1064071)) II 1 NT_166518.1 hypothetical protein 1064071 84589924 An01g04500 Aspergillus niger hypothetical protein XP_059599633.1 1063262 R 5061 CDS An01g04510 84589925 join(1065585..1065598,1065667..1065799) II 1 NT_166518.1 hypothetical protein 1065799 84589925 An01g04510 Aspergillus niger hypothetical protein XP_059599634.1 1065585 D 5061 CDS An01g04520 4977208 join(1066791..1067426,1067505..1067594,1067651..1067833,1067890..1068370,1068421..1068592,1068644..1068805,1068859..1069305,1069361..1069802,1069838..1069966) II 1 NT_166518.1 Function: D. melanogaster mus308 encodes a theta DNA polymerase involved in DNA repair.; Function: mus308 is required in D. melanogaster to process ethyl nitrosourea (ENU) induced lesions, and may play a role in post replication bypass of O-alkylpyrimidines, probably mediated by recombination,which serves to increase the time available for error-free repair of these lesions.; Similarity: mus308 of D. melanogaster and other similar proteins are twice longer than the predicted proetin.; Title: similarity to theta DNA polymerase mus308 -Drosophila melanogaster; See PMID 8417992; See PMID 8816490; See PMID 9539982; See PMID 10343651; See PMID 10732683; uncharacterized protein 1069966 4977208 An01g04520 Aspergillus niger uncharacterized protein XP_059599635.1 1066791 D 5061 CDS An01g04530 4977146 complement(join(1070331..1070692,1070748..1071294)) II 1 NT_166518.1 Similarity: strong similarity to A. niger EST EMBLEST:BE760850.; Similarity: the predicted ORF does not contain structural features common to protein kinases.; Title: similarity to hypothetical MAP3K protein kinase-like protein MLD14.3 - Arabidopsis thaliana; uncharacterized protein 1071294 4977146 An01g04530 Aspergillus niger uncharacterized protein XP_001388881.1 1070331 R 5061 CDS An01g04540 4977834 join(1072154..1072341,1072637..1072969,1073026..1073425) II 1 NT_166518.1 hypothetical protein 1073425 4977834 An01g04540 Aspergillus niger hypothetical protein XP_059599636.1 1072154 D 5061 CDS An01g04550 84589926 join(1073768..1073870,1073927..1077688,1078042..1078190) II 1 NT_166518.1 Function: VPS8 of S. cerevisiae is involved in vacuolar protein sorting and required for localization and trafficking of the CPY sorting receptor.; Similarity: VPS8 of S. cerevisiae is a membrane-associated hydrophilic protein which contains a C-terminal cysteine-rich region that conforms to the H2 variant of the RING finger Zn2+ binding motif.; Similarity: the predicted protein does not contain such a RING finger.; Title: strong similarity to vacuolar protein sorting-associated protein Vps8 - Saccharomyces cerevisiae; See PMID 8864656; See PMID 8969229; See PMID 9412470; See PMID 3062374; uncharacterized protein 1078190 84589926 An01g04550 Aspergillus niger uncharacterized protein XP_059599637.1 1073768 D 5061 CDS An01g04560 4978336 join(1079026..1079396,1079478..1079904,1080000..1080500) II 1 NT_166518.1 Function: mixed-linked glucanases (MLGases) are extracellular enzymes able to hydrolyze beta 1,3-1,4-glucans.; Similarity: the C-terminal part of the predicted protein has similarity to a calcium binding domain found e. g. in a penicillin-binding protein of Bacillus subtilis.; Similarity: the product of MLG1 of C. carbonum has no close similarity to any known protein but does contain a motif (EIDI) that occurs at the active site of MLGases from several prokaryotes; this motif is conserved in the predicted protein.; Title: strong similarity to mixed-linked glucanase precursor MLG1 - Cochliobolus carbonum; extracellular/secretion proteins; See PMID 9464371; uncharacterized protein 1080500 4978336 An01g04560 Aspergillus niger uncharacterized protein XP_001388884.1 1079026 D 5061 CDS An01g04570 4978412 complement(join(1080911..1082486,1082536..1082966,1083013..1083159,1083215..1083628,1083685..1084007,1084063..1084121,1084201..1084244)) II 1 NT_166518.1 Function: CAP10 of C. neoformans is a cytoplasmic protein required for capsule formation.; Remark: C. neoformans is a pathogenic fungus which most commonly affects the central nervous system and causes fatal meningoencephalitis primarily in patients with AIDS,and produces a thick extracellular polysaccharide capsule which is well recognized as a virulence factor.; Title: strong similarity to capsular associated protein CAP10 - Filobasidiella neoformans; cytoplasm; See PMID 10482503; uncharacterized protein 1084244 4978412 An01g04570 Aspergillus niger uncharacterized protein XP_001388885.1 1080911 R 5061 CDS An01g04590 4977260 join(1086015..1089013,1089103..1089310) II 1 NT_166518.1 Function: KRE33 of S. cerevisiae, also called YNL132W, is a protein extremely conserved till humans; the molecular function is unknown, but the gene is claimed to be involved in killer toxin resistance, although the results are still unpublished.; Phenotype: null mutation of KRE33 in S. cerevisiae is lethal.; Title: strong similarity to hypothetical protein Kre33 - Saccharomyces cerevisiae; uncharacterized protein 1089310 4977260 An01g04590 Aspergillus niger uncharacterized protein XP_001388886.1 1086015 D 5061 CDS An01g04600 4978424 complement(join(1089714..1090947,1091013..1091020,1091082..1091234)) II 1 NT_166518.1 Function: the evidences suggesting the existence and expression of prpA in A. niger are very strong, although no function could be clearly demonstrated for the gene product.; Gene-ID: prpA; Phenotype: an A. niger strain containing a deletion of the prpA gene is viable; however, deletion of the prpA gene causes a reduction of exogenous proteins production.; Similarity: prpA is similar to protein disulfide isomerase (PDI), an enzyme important in assisting the folding and maturation of secretory proteins in eukaryotes.; See PMID 9021130; See PMID 10653750; See PMID 10672446; PDI related protein A prpA-Aspergillus niger 1091234 prpA 4978424 prpA Aspergillus niger PDI related protein A prpA-Aspergillus niger XP_001388887.1 1089714 R 5061 CDS An01g04610 4978378 1091764..1093311 II 1 NT_166518.1 Title: similarity to hypothetical protein CAE76271.1 - Neurospora crassa; uncharacterized protein 1093311 4978378 An01g04610 Aspergillus niger uncharacterized protein XP_001388888.1 1091764 D 5061 CDS An01g04620 4978104 complement(join(1093500..1095152,1095281..1095445)) II 1 NT_166518.1 Function: the DnaJ-domain is part of a chaperone (protein folding) system.; Similarity: the main feature of the predicted protein is to contain a C-terminal DnaJ domain; the domain covers just 10% of the total protein lenght.; Title: weak similarity to immunogenic protein #16513 from patent WO200181581-A2 - Propionibacterium acnes; uncharacterized protein 1095445 4978104 An01g04620 Aspergillus niger uncharacterized protein XP_001388889.1 1093500 R 5061 CDS An01g04630 4978331 complement(join(1095895..1095988,1096040..1096074,1096127..1096147,1096207..1096319,1096379..1096953,1097153..1097208)) II 1 NT_166518.1 Complex: more in detail, ATP3 is a part of the F1 complex, a water soluble subunit which retain the ATPase activity but not the proton-transporting activity.; Function: ATP3 of S. cerevisiae is a component of the H+-transporting ATP synthase complex, a mitochondrial membrane-bound enzyme in which transport of protons is coupled with ATP synthesis.; Remark: in the gene model, a non conventional splice donor (GC instead of GT) was used in the 3' position of exon 4, due to the identity to A. niger EST SEQ ID NO:3921 of patent WO200056762-A2 and the local identity to the fungal homologues.; Title: strong similarity to gamma chain precursor of the H+-transporting ATP synthase Atp3 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 7929329; See PMID 9857174; See PMID 10953875; See PMID 7498726; uncharacterized protein 1097208 4978331 An01g04630 Aspergillus niger uncharacterized protein XP_001388890.1 1095895 R 5061 CDS An01g04640 4978442 join(1098217..1098271,1098457..1098674,1098770..1100326,1100377..1100616,1100686..1101135,1101192..1101326) II 1 NT_166518.1 Catalytic activity: ATP-independent breakage of single-stranded DNA,followed by passage and rejoining.; Catalytic activity: when a topoisomerase transiently breaks a DNA backbone bond,it simultaneously forms a protein-DNA link,in which a tyrosyl oxygen in the enzyme is joined to a DNA phosphorus at one end of the enzyme-severed DNA strand.; Function: the reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another; eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.; Similarity: the predicted protein shows very strong similarity to the A. nidulans topoisomerase, whose catalytic activity was not experimentally reported.; Title: strong similarity to topoisomerase I CaTOP1 -Candida albicans; nucleus; See PMID 9026437; uncharacterized protein 1101326 4978442 An01g04640 Aspergillus niger uncharacterized protein XP_001388891.1 1098217 D 5061 CDS An01g04650 4977100 complement(join(1102904..1103814,1103916..1104077,1104152..1104203)) II 1 NT_166518.1 Remark: the encoded protein also shows weak similarities to UDPglucose 4-epimerase galE from Neisseria gonorrhoeae.; Title: strong similarity to sequence SEQ ID NO:12396 from patent WO200171042-A2 - Drosophila melanogaster; uncharacterized protein 1104203 4977100 An01g04650 Aspergillus niger uncharacterized protein XP_001388892.1 1102904 R 5061 CDS An01g04660 4977250 complement(join(1107129..1107956,1108030..1108105,1108412..1108770)) II 1 NT_166518.1 hypothetical protein 1108770 4977250 An01g04660 Aspergillus niger hypothetical protein XP_001388893.1 1107129 R 5061 CDS An01g04670 4978414 complement(join(1109548..1110472,1110524..1110651,1110729..1110829,1110908..1111010)) II 1 NT_166518.1 Similarity: proline-rich regions lead to a variety of unspecific similarities.; Title: similarity to hypothetical protein F10M23.90 - Arabidopsis thaliana; uncharacterized protein 1111010 4978414 An01g04670 Aspergillus niger uncharacterized protein XP_001388894.1 1109548 R 5061 CDS An01g04680 4978314 complement(join(1111408..1113324,1113381..1113612,1113684..1114057,1114137..1114187)) II 1 NT_166518.1 Function: palB of A. nidulans is a factor involved in ambient pH signalling transduction pathway.; Remark: calpains are cytosolic cysteine proteases that are activated by a rise in intracellular Ca2+, and are believed to function in stimulating Ca2+ signaling.; Title: strong similarity to calpain-like protease palB - Aspergillus nidulans; cytoplasm; See PMID 7499363; See PMID 7581026; uncharacterized protein 1114187 4978314 An01g04680 Aspergillus niger uncharacterized protein XP_001388895.1 1111408 R 5061 CDS An01g04690 4978157 join(1115049..1115149,1115222..1115766,1115822..1116059,1116110..1116233) II 1 NT_166518.1 Function: Ant1 of S. cerevisiae is a peroxisomal transporter involved in the transport of cytoplasmic ATP into the peroxisomal lumen in exchange for AMP.; Induction: Ant1 of S. cerevisiae is induced by oleic acid.; Localization: Ant1 of S. cerevisiae is localized in the peroxisomal membrane.; Remark: ATP imported into the peroxisome is required for the activation of fatty acids.; Title: strong similarity to peroxisomal transporter Ant1 - Saccharomyces cerevisiae; peroxisome; See PMID 11566870; uncharacterized protein 1116233 4978157 An01g04690 Aspergillus niger uncharacterized protein XP_001388896.1 1115049 D 5061 CDS An01g04700 4977593 join(1116780..1117157,1117245..1117694) II 1 NT_166518.1 Title: weak similarity to thermostable nuclease Tnase nuch - Staphylococcus hyicus; See PMID 8045422; uncharacterized protein 1117694 4977593 An01g04700 Aspergillus niger uncharacterized protein XP_001388897.1 1116780 D 5061 CDS An01g04710 4978474 complement(join(1118175..1118707,1118788..1118959)) II 1 NT_166518.1 Catalytic activity: ATP + AMP = ADP + ADP.; Function: adenylate kinase is required for cell maintenance and cell growth.; Localization: adenylate kinase ADK2 from S. cerevisiae is located in the mitochindrial matrix.; Remark: ADK2 of S. cerevisiae is also known as AKY3,PAK3 and YER170W.; Similarity: adenylate kinases are highly conserved.; Title: strong similarity to adenylate kinase Adk2 -Saccharomyces cerevisiae; See PMID 9425120; See PMID 1587477; See PMID 1620094; uncharacterized protein 1118959 4978474 An01g04710 Aspergillus niger uncharacterized protein XP_001388898.1 1118175 R 5061 CDS An01g04720 4978025 join(1120003..1120192,1120245..1120795,1120847..1121608) II 1 NT_166518.1 Complex: eukaryotic DNA primase is a heterodimer of a large subunit (p58) and a small subunit (p48).; Function: DNA primase initiates the synthesis of new DNA strands by synthesizing short RNA oligomers on single-stranded DNA, is essential for telomere maintenance and so chromosome stability.; Title: strong similarity to DNA primase large subunit Pri2 - Saccharomyces cerevisiae; See PMID 11084371; See PMID 2528682; uncharacterized protein 1121608 4978025 An01g04720 Aspergillus niger uncharacterized protein XP_001388899.1 1120003 D 5061 CDS An01g04730 4977081 join(1122380..1122472,1122529..1122659,1122724..1123018,1123084..1123554,1123611..1124708,1124763..1124956,1125014..1125038) II 1 NT_166518.1 Complex: sec23 interacts with 5 other proteins,namely sec13, sec16, sec24, sec31 and sar1, to form the coat protein II - coated vesicle (COPII) complex.; Function: sec23 is required for transport of secretory, plasma membrane and vacuolar proteins from the endoplasmic reticulum to the Golgi apparatus.; Localization: sec23 is located on the cytoplasmic surface of either the cytoskeleton or the membrane.; Remark: sec23 binds directly to the C-terminus of sec16.; Similarity: sec23 is highly conserved.; Title: strong similarity to secretory protein Sec23 - Saccharomyces cerevisiae; See PMID 8930902; See PMID 1498369; See PMID 2670558; uncharacterized protein 1125038 4977081 An01g04730 Aspergillus niger uncharacterized protein XP_001388900.1 1122380 D 5061 CDS An01g04740 4978288 join(1125481..1125484,1125545..1125578,1125645..1125765,1125832..1126156,1126212..1126225) II 1 NT_166518.1 Remark: the ORF overlaps with A. niger EST an_2410 in EMBLEST.; Similarity: ribosomal protein L12 is highly conserved.; Title: strong similarity to ribosomal protein of the large subunit L12 - Mus musculus; See PMID 8359697; 60S ribosomal protein uL11 1126225 4978288 An01g04740 Aspergillus niger 60S ribosomal protein uL11 XP_001388901.1 1125481 D 5061 CDS An01g04750 84589927 complement(join(1128589..1128655,1128697..1128869)) II 1 NT_166518.1 Remark: the ORF is a short.; hypothetical protein 1128869 84589927 An01g04750 Aspergillus niger hypothetical protein XP_059599638.1 1128589 R 5061 CDS An01g04760 4977567 join(1131918..1133686,1133736..1135087,1135460..1136349,1136402..1137031) II 1 NT_166518.1 Similarity: similarity to N-acetylglucosaminyltransferase chain p110 from R. norvegicus is only over C-terminal region.; Title: similarity to hypothetical protein B12K8.10 -Neurospora crassa; uncharacterized protein 1137031 4977567 An01g04760 Aspergillus niger uncharacterized protein XP_059599639.1 1131918 D 5061 CDS An01g04770 84589928 complement(1137725..1139395) II 1 NT_166518.1 hypothetical protein 1139395 84589928 An01g04770 Aspergillus niger hypothetical protein XP_059599640.1 1137725 R 5061 CDS An01g04790 84589929 complement(join(1140291..1140356,1140528..1140614,1140722..1140884,1140978..1141022,1141139..1141210,1141306..1141370)) II 1 NT_166518.1 hypothetical protein 1141370 84589929 An01g04790 Aspergillus niger hypothetical protein XP_059599641.1 1140291 R 5061 CDS An01g04800 84589930 join(1141966..1142081,1142244..1142435,1142514..1142721) II 1 NT_166518.1 hypothetical protein 1142721 84589930 An01g04800 Aspergillus niger hypothetical protein XP_059599642.1 1141966 D 5061 CDS An01g04810 84589931 join(1143914..1144048,1144162..1144314,1144735..1144786,1144873..1144964) II 1 NT_166518.1 hypothetical protein 1144964 84589931 An01g04810 Aspergillus niger hypothetical protein XP_059599643.1 1143914 D 5061 CDS An01g04820 84589932 join(1146084..1146163,1146248..1146355,1146470..1146570,1146991..1147190,1147272..1147322) II 1 NT_166518.1 Remark: the ORF has an unusual exon/intron structure.; hypothetical protein 1147322 84589932 An01g04820 Aspergillus niger hypothetical protein XP_059599644.1 1146084 D 5061 CDS An01g04830 4978271 complement(1154364..1155293) II 1 NT_166518.1 Function: the flbD gene from Aspergillus nidulans encodes a protein with a Myb-like DNA-binding domain that is proposed to act in concert with other developmental regulators to control initiation of conidiophore development.; Function: the flbD gene from Aspergillus nidulans is involved in the coordination of initiation of conidiophore development.; Title: strong similarity to myb-like DNA binding protein flbD - Aspergillus nidulans; nucleus; See PMID 7883170; See PMID 9539422; uncharacterized protein 1155293 4978271 An01g04830 Aspergillus niger uncharacterized protein XP_001388909.1 1154364 R 5061 CDS An01g04840 84589933 complement(join(1157037..1157262,1157575..1157888,1158051..1158131)) II 1 NT_166518.1 hypothetical protein 1158131 84589933 An01g04840 Aspergillus niger hypothetical protein XP_059599645.1 1157037 R 5061 CDS An01g04850 84589934 join(1158507..1158636,1158818..1159055,1159108..1159197,1159297..1159360) II 1 NT_166518.1 Title: weak similarity to hypothetical protein BAB09566.1 - Arabidopsis thaliana; uncharacterized protein 1159360 84589934 An01g04850 Aspergillus niger uncharacterized protein XP_059599646.1 1158507 D 5061 CDS An01g04860 84589935 join(1159801..1159814,1159912..1159967,1160042..1160151,1160232..1160248,1160520..1160601,1160695..1160746,1160781..1160809,1160952..1161053,1161272..1161361,1161444..1161467) II 1 NT_166518.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1161467 84589935 An01g04860 Aspergillus niger uncharacterized protein XP_059599647.1 1159801 D 5061 CDS An01g04870 84589936 complement(join(1162942..1163235,1163280..1163339,1163379..1163492,1163891..1164106,1164172..1164277,1164357..1164431,1164557..1164589,1164700..1164789,1164901..1165022,1165171..1165565,1165649..1165850,1165952..1166026,1166109..1166243)) II 1 NT_166518.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1166243 84589936 An01g04870 Aspergillus niger uncharacterized protein XP_059599648.1 1162942 R 5061 CDS An01g04880 4977344 complement(join(1166572..1167656,1167731..1168613)) II 1 NT_166518.1 Complex: B. thermoamyloliquefaciens alpha-glucosidase II is a homohexamer; Function: B. thermoamyloliquefaciens alpha-glucosidase II is involved in polysaccharide meatabolism.; Remark: a splice site upstream of the start codon was detected.; Similarity: B. thermoamyloliquefaciens alpha-glucosidase II belongs to the glycosyl hydrolase family 31.; Title: strong similarity to alpha-glucosidase II -Bacillus thermoamyloliquefaciens; See PMID 10945254; uncharacterized protein 1168613 4977344 An01g04880 Aspergillus niger uncharacterized protein XP_001388914.1 1166572 R 5061 CDS An01g04890 84589937 complement(join(1168854..1168924,1169065..1169144,1169457..1169529,1169584..1169756,1169887..1169983,1170038..1170126,1170337..1170446)) II 1 NT_166518.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1170446 84589937 An01g04890 Aspergillus niger uncharacterized protein XP_059599649.1 1168854 R 5061 CDS An01g04900 4977083 join(1170822..1170965,1171038..1172321) II 1 NT_166518.1 Title: strong similarity to hypothetical protein CAC18296.1 - Neurospora crassa; uncharacterized protein 1172321 4977083 An01g04900 Aspergillus niger uncharacterized protein XP_001388916.1 1170822 D 5061 CDS An01g04910 4978105 join(1172737..1172998,1173055..1174205,1174321..1174359,1174471..1174617) II 1 NT_166518.1 Title: similarity to hypothetical protein EAK99938.1 - Candida albicans; uncharacterized protein 1174617 4978105 An01g04910 Aspergillus niger uncharacterized protein XP_001388917.3 1172737 D 5061 CDS An01g04920 4978171 complement(join(1174834..1174869,1174943..1175045,1175323..1175374,1175510..1175516)) II 1 NT_166518.1 Complex: S. cerevisiae L29 is part of the 60S subunit of the ribosome.; Function: S. cerevisiae ribosomal protein L29 is involved in the biosynthesis of proteins.; Remark: an alternative name for S. cerevisiae L29 is YL34, or RPL29.; Remark: the original reference for the isolation of S. cerevisiae L29 is Otaka, E.; Higo, K. I.; Itoh, T; Mol. Gen. Genet. 195: 544-546 (1984) which is not available via PubMed.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L29 - Saccharomyces cerevisiae; cytoplasm; See PMID 9008165; 60S ribosomal protein eL29 1175516 4978171 An01g04920 Aspergillus niger 60S ribosomal protein eL29 XP_001388918.1 1174834 R 5061 CDS An01g04930 4977147 join(1176609..1176740,1176817..1176839,1176932..1177062,1177173..1177261,1177326..1177415,1177471..1177503) II 1 NT_166518.1 Catalytic activity: S. cerevisiae ATP Synthase delta chain produces ATP from ADP in the presence of a proton gradient.; Complex: S. cerevisiae ATP Synthase delta chain is part of the catlytic heteromeric complex ATP-synthase.; Function: S. cerevisiae ATP Synthase delta chain is involved in ATP synthesis.; Remark: the systematic name for ATP16 of S. cerevisiae is YDL004W.; Title: strong similarity to ATP synthase delta chain Atp16 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8026496; uncharacterized protein 1177503 4977147 An01g04930 Aspergillus niger uncharacterized protein XP_001388919.1 1176609 D 5061 CDS An01g04940 84589938 1177837..1179222 II 1 NT_166518.1 hypothetical protein 1179222 84589938 An01g04940 Aspergillus niger hypothetical protein XP_059599650.1 1177837 D 5061 CDS An01g04950 4977697 complement(join(1179842..1181692,1181747..1182114,1182165..1182315)) II 1 NT_166518.1 Similarity: similarity is from the N-terminal region of the predicted A. niger protein to A. thaliana At2g30890, which is 500aa shorter.; Title: weak similarity to hypothetical protein At2g30890 - Arabidopsis thaliana; uncharacterized protein 1182315 4977697 An01g04950 Aspergillus niger uncharacterized protein XP_059599651.1 1179842 R 5061 CDS An01g04960 84589939 join(1182601..1182669,1182834..1182993,1183076..1183329) II 1 NT_166518.1 hypothetical protein 1183329 84589939 An01g04960 Aspergillus niger hypothetical protein XP_059599652.1 1182601 D 5061 CDS An01g04970 4978273 join(1183493..1183533,1183608..1183625,1183718..1184156,1184228..1184596) II 1 NT_166518.1 Function: human CTNS is a lysosomal cystine transporter.; Function: mutations in human CTNS cause nephropathic cystinosis, an autosomal recessive disorder resulting from defective lysosomal transport of cystine.; Localization: human cystinosin-green fluorescent protein colocalizes with lysosomal-associated membrane protein 2 (LAMP-2) to lysosomes.; Title: strong similarity to lysosomal cystine transporter cystinosin CTNS - Homo sapiens; lysosome; See PMID 9537412; See PMID 10673275; See PMID 11150305; uncharacterized protein 1184596 4978273 An01g04970 Aspergillus niger uncharacterized protein XP_001388923.1 1183493 D 5061 CDS An01g04980 4978131 join(1186471..1186577,1186665..1187622) II 1 NT_166518.1 Function: Fusarium sp. Tri6 is involved in the regulation of enzymes, of the trichothecene toxin biosynthesis pathway.; Remark: the predicted A. niger protein contains a zinc-finger-domain in the C-terminus.; Remark: trichothecenes are sesquiterpenoid mycotoxins and act as protein synthesis inhibitors for eukaryotic organisms.; Similarity: the predicted A. niger protein shows strong similarity to Tri6 transcription activators of several Fusarium species (F. graminearum, F. cerealis, F. sporotrichioides).; Title: similarity to transcription activator Tri6 -Fusarium cerealis; nucleus; See PMID 10635566; uncharacterized protein 1187622 4978131 An01g04980 Aspergillus niger uncharacterized protein XP_001388924.3 1186471 D 5061 CDS An01g04990 4977646 complement(1189457..1190668) II 1 NT_166518.1 Similarity: the predicted A. niger protein shows local similarity to the integrase gene in Pseudomonas putida (aa 169-317); hypothetical protein 1190668 4977646 An01g04990 Aspergillus niger hypothetical protein XP_059599653.1 1189457 R 5061 CDS An01g05000 84589940 join(1194351..1194367,1194408..1194426,1194486..1194572,1194645..1194905) II 1 NT_166518.1 Similarity: similarity is between the N-terminal regions of the predicted A. niger protein and the polyguluronate lyase gene of Corynebacterium sp. (aa 7-67).; Title: weak similarity to polyguluronate lyase alyPG - Corynebacterium sp.; See PMID 9491925; uncharacterized protein 1194905 84589940 An01g05000 Aspergillus niger uncharacterized protein XP_059599654.1 1194351 D 5061 CDS An01g05010 84589941 complement(join(1195282..1195308,1195544..1195621,1195703..1195746,1195817..1195831,1195939..1195981,1196195..1196248)) II 1 NT_166518.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1196248 84589941 An01g05010 Aspergillus niger uncharacterized protein XP_059599655.1 1195282 R 5061 CDS An01g05020 84589942 complement(join(1196917..1196995,1197068..1197158,1197336..1197446,1197546..1197555,1197637..1197807)) II 1 NT_166518.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1197807 84589942 An01g05020 Aspergillus niger uncharacterized protein XP_059599656.1 1196917 R 5061 CDS An01g05030 4977211 complement(join(1198094..1198793,1198919..1199214,1199270..1199406,1199532..1199577)) II 1 NT_166518.1 Title: strong similarity to oxidoreductase OXRD-8 from patent WO200071679-A2 - Homo sapiens; uncharacterized protein 1199577 4977211 An01g05030 Aspergillus niger uncharacterized protein XP_001388929.3 1198094 R 5061 CDS An01g05040 4978165 join(1199876..1200215,1200297..1200469,1200553..1200636) II 1 NT_166518.1 Complex: dUTP pyrophosphatases are homotrimeric enzymes.; Function: dUTP pyrophosphatases hydrolyze dUTP to dUMP and pyrophosphate, preventing the incorporation of uracil into DNA during replication, and are involved in DNA replication and DNA repair.; Title: strong similarity to dUTP pyrophosphatase DUT1 - Candida albicans; See PMID 7874734; See PMID 8223452; uncharacterized protein 1200636 4978165 An01g05040 Aspergillus niger uncharacterized protein XP_001388930.1 1199876 D 5061 CDS An01g05050 4978204 complement(join(1200883..1201510,1201561..1201678,1201738..1201950,1202001..1202080,1202160..1202170,1202228..1202281)) II 1 NT_166518.1 Catalytic activity: pyridoxal kinases convert ATP + pyridoxal to ADP + pyridoxal-5-phosphat.; Function: human PKH is required for the synthesis of pyridoxal-5-phosphate (PLP)1, an essential cofactor for numerous enzymic reactions of intermediary metabolism, from vitaminB6.; Remark: an alternative name for human PKH is PNK.; Title: strong similarity to pyridoxal kinase PKH -Homo sapiens; See PMID 9099727; uncharacterized protein 1202281 4978204 An01g05050 Aspergillus niger uncharacterized protein XP_001388931.1 1200883 R 5061 CDS An01g05060 4978209 1203129..1204229 II 1 NT_166518.1 Title: strong similarity to hypothetical protein EAA66142.1 - Aspergillus nidulans; uncharacterized protein 1204229 4978209 An01g05060 Aspergillus niger uncharacterized protein XP_001388932.1 1203129 D 5061 CDS An01g05070 4978023 complement(join(1204521..1206191,1206245..1206305,1206358..1206989)) II 1 NT_166518.1 Title: strong similarity to hypothetical protein SPBC776.06c - Schizosaccharomyces pombe; uncharacterized protein 1206989 4978023 An01g05070 Aspergillus niger uncharacterized protein XP_001388933.1 1204521 R 5061 CDS An01g05080 4978319 join(1207855..1207857,1207916..1208390,1208472..1208872) II 1 NT_166518.1 Similarity: similarity is from the C-terminal half of the predicted A. niger protein to myosin regulator light chain from P. yessoensis, which is 100 aa shorter.; Title: similarity to myosin regulatory light chain -Patinopecten yessoensis; cytoskeleton; See PMID 6706905; uncharacterized protein 1208872 4978319 An01g05080 Aspergillus niger uncharacterized protein XP_059599657.1 1207855 D 5061 CDS An01g05090 4977921 join(1209775..1210146,1210237..1210472,1210602..1211015,1211349..1211472) II 1 NT_166518.1 Complex: S. pombe cdc16 forms a heterodimer with byr4, which then binds spglp.; Function: S. pombe cdc16 is required for p34cdc2 kinase activity and septum formation.; Function: S. pombe cdc16 negatively regulates septation via Spglp GTPase and its effector cdc7 kinase.; Function: S. pombe cdc16 together with byr4 forms a two-component GTPase-activating protein (GAP) regulating Spglp GTPase.; Localization: using indirect immunofluorescence byr4 localises to the spindle pole bodies except during mitosis.; Similarity: S. pombe cdc16 belongs to the superfamily of cell cycle arrest proteins BUB2.; Title: strong similarity to cell division control protein cdc16p - Schizosaccharomyces pombe; centrosome; See PMID 9742395; See PMID 11271422; See PMID 8334988; uncharacterized protein 1211472 4977921 An01g05090 Aspergillus niger uncharacterized protein XP_059599658.1 1209775 D 5061 CDS An01g05100 4977866 complement(join(1212690..1213530,1213586..1213781,1213833..1213989,1214047..1214127)) II 1 NT_166518.1 Function: N. sylvestris cp29B exists as complex with ribosome-free mRNAs and possibly acts as stabilizing factor.; Localization: N. sylvestris ribonucleoprotein B 29K has been identified from a tobacco chloroplast lysate.; Remark: N. sylvestris ribonucleoprotein B 29K is nuclear encoded.; Similarity: the predicted ORF contains the RNA recognition motiv PF00076 (aa 273-314).; Title: weak similarity to ribonucleoprotein B cp29B - Nicotiana sylvestris; See PMID 11038367; See PMID 1721701; uncharacterized protein 1214127 4977866 An01g05100 Aspergillus niger uncharacterized protein XP_001388936.1 1212690 R 5061 CDS An01g05110 84589943 join(1214568..1214705,1214791..1214955) II 1 NT_166518.1 hypothetical protein 1214955 84589943 An01g05110 Aspergillus niger hypothetical protein XP_059599659.1 1214568 D 5061 CDS An01g05120 84589944 complement(join(1215606..1215728,1215809..1215945,1216060..1216071,1216159..1216209,1216421..1216506,1216587..1216634,1216702..1216844)) II 1 NT_166518.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1216844 84589944 An01g05120 Aspergillus niger uncharacterized protein XP_059599660.1 1215606 R 5061 CDS An01g05130 84589945 complement(join(1217126..1217247,1217488..1217513,1217593..1217626,1217797..1217893,1217987..1218208,1218301..1218436,1218641..1218681)) II 1 NT_166518.1 hypothetical protein 1218681 84589945 An01g05130 Aspergillus niger hypothetical protein XP_059599661.1 1217126 R 5061 CDS An01g05140 84589946 join(1220341..1220519,1220599..1220619,1220709..1220729,1220780..1220860,1220934..1221050,1221118..1221460,1221558..1221620,1221728..1221832,1221925..1221948,1222134..1222258,1222485..1222548,1222941..1223270) II 1 NT_166518.1 hypothetical protein 1223270 84589946 An01g05140 Aspergillus niger hypothetical protein XP_059599662.1 1220341 D 5061 CDS An01g05150 4978395 1226717..1227517 II 1 NT_166518.1 Function: S. cerevisiae SOL1 suppresses mutations in LOS1, which is a regulator of gene products involved in tRNA expression/function as well as pre-tRNA splicing.; Function: yeast Sol proteins affect tRNA expression/ function at steps other than transcription or splicing.; Induction: LOS1 appears to positively regulate SOL1.; Similarity: similarities from yeast Sol proteins to G6PDs are restricted to areas separate from the catalytic domain.; Similarity: yeast Sol proteins have extensive similarity to an unusual group of glucose-6-phosphate dehydrogenases.; Title: strong similarity to Sol1 - Saccharomyces cerevisiae; See PMID 8725220; uncharacterized protein 1227517 4978395 An01g05150 Aspergillus niger uncharacterized protein XP_001388941.1 1226717 D 5061 CDS An01g05160 4977399 join(1227553..1227693,1227957..1228095,1228183..1228235,1228359..1229930) II 1 NT_166518.1 Similarity: the predicted A. niger protein contains several WSC domains which are putative carbohydrate binding domains.; Similarity: the predicted A. niger protein shows likely unspecific similarity to serine, proline and threonine rich proteins.; Title: weak similarity to chitinase chiA -Aspergillus nidulans; See PMID 9501518; uncharacterized protein 1229930 4977399 An01g05160 Aspergillus niger uncharacterized protein XP_059599663.1 1227553 D 5061 CDS An01g05180 4978313 join(1232747..1232904,1233006..1236126,1236197..1236307,1236530..1236551,1236771..1237651,1237842..1238563,1238730..1238733) II 1 NT_166518.1 Title: strong similarity to hypothetical guanine nucleotide binding protein beta subunit-like protein -Schizosaccharomyces pombe; uncharacterized protein 1238733 4978313 An01g05180 Aspergillus niger uncharacterized protein XP_059599664.1 1232747 D 5061 CDS An01g05190 4978393 complement(1239266..1241962) II 1 NT_166518.1 Title: strong similarity to hypothetical protein SPBC15D4.16 - Schizosaccharomyces pombe; uncharacterized protein 1241962 4978393 An01g05190 Aspergillus niger uncharacterized protein XP_001388944.1 1239266 R 5061 CDS An01g05200 4977036 join(1242326..1242382,1242443..1242628) II 1 NT_166518.1 Function: DPM2 of M. musculus essential for the ER localization and stable expression of DPM1.; Function: DPM2 of M. musculus regulates the biosynthesis of dolichol phosphate-mannose.; Localization: DPM2 of M. musculus is an integral membrane protein in the endoplasmic reticulum.; Remark: DPM2 of M. musculus interacts with DPM1.; Similarity: DPM2 of M. musculus belongs to the DPM2 family.; Title: strong similarity to DPM2 - Mus musculus; endoplasmatic reticulum; See PMID 9724629; uncharacterized protein 1242628 4977036 An01g05200 Aspergillus niger uncharacterized protein XP_001388945.3 1242326 D 5061 CDS An01g05210 4977983 join(1243042..1243171,1243279..1243523,1243559..1243618,1243681..1243805,1243886..1244048,1244126..1244223,1244353..1244459,1244532..1244715,1244801..1245649,1245708..1245720) II 1 NT_166518.1 Remark: blastp matches are unspecific.; hypothetical protein 1245720 4977983 An01g05210 Aspergillus niger hypothetical protein XP_059599665.1 1243042 D 5061 CDS An01g05220 84589947 1245885..1247903 II 1 NT_166518.1 Remark: blastp matches are unspecific; hypothetical protein 1247903 84589947 An01g05220 Aspergillus niger hypothetical protein XP_059599666.1 1245885 D 5061 CDS An01g05230 4978262 complement(join(1249417..1249568,1249635..1249913,1250080..1250209)) II 1 NT_166518.1 Remark: the ORF shows also strong similarity to EST an_2899 from Aspergillus niger.; Title: weak similarity to hypothetical protein CAE76314.1 - Neurospora crassa; uncharacterized protein 1250209 4978262 An01g05230 Aspergillus niger uncharacterized protein XP_001388948.1 1249417 R 5061 CDS An01g05240 84589948 join(1250403..1250675,1250735..1250851,1251029..1251168,1251302..1251505,1251570..1251690) II 1 NT_166518.1 hypothetical protein 1251690 84589948 An01g05240 Aspergillus niger hypothetical protein XP_059599667.1 1250403 D 5061 CDS An01g05250 84589949 complement(join(1251771..1251878,1251972..1252092,1252158..1252267,1252362..1252385)) II 1 NT_166518.1 hypothetical protein 1252385 84589949 An01g05250 Aspergillus niger hypothetical protein XP_059599668.1 1251771 R 5061 CDS An01g05260 4978206 1253556..1256210 II 1 NT_166518.1 Function: S. cerevisiae Mph1p is required for the protection of the genome from spontaneous and chemically induced damage.; Function: S. cerevisiae mph1 mutants display a spontaneous mutator phenotyp.; Function: in S. cerevisiae the mph1 mutator phenotype was dependent on REV3 and RAD6.; Function: it has been proposed that Mph1 affects the rate of DNA lesion formation, e. g., by modulating the susceptibility of DNA to chemical attack through compaction of Chromatin, changes of DNA twist or changes of secondary structure.; Remark: the systematic name for S. cerevisiae MPH1 is YIR002c.; Similarity: S. cerevisiae Mph1p shows strong similarity to ATP-dependent RNA helicases.; Title: strong similarity to DEAH protein Mph1 -Saccharomyces cerevisiae; nucleus; See PMID 10880470; uncharacterized protein 1256210 4978206 An01g05260 Aspergillus niger uncharacterized protein XP_001388951.3 1253556 D 5061 CDS An01g05270 4978387 complement(join(1256674..1256821,1256893..1257066,1257151..1257345,1257466..1257650)) II 1 NT_166518.1 Title: weak similarity to extracellular proteinase prtY - Lactobacillus helveticus; See PMID 10923793; uncharacterized protein 1257650 4978387 An01g05270 Aspergillus niger uncharacterized protein XP_001388952.1 1256674 R 5061 CDS An01g05280 4977925 join(1259037..1259081,1259142..1259714) II 1 NT_166518.1 Title: strong similarity to hypothetical protein encoded by An11g07100 - Aspergillus niger; uncharacterized protein 1259714 4977925 An01g05280 Aspergillus niger uncharacterized protein XP_001388953.1 1259037 D 5061 CDS An01g05290 4978114 join(1260266..1260294,1260335..1260795,1260859..1261129,1261209..1261278,1261310..>1261427) II 1 NT_166518.1 Remark: a possible sequencing error occured and was corrected with a frame shift of 1 bp.; Remark: the extracted protein is N-terminal longer than most of the matching proteins.; Title: strong similarity to actin-capping protein beta chain - Gallus gallus [putative frameshift]; cytoskeleton; putative frameshift; See PMID 2745461; uncharacterized protein 1261427 4978114 An01g05290 Aspergillus niger uncharacterized protein XP_059603150.1 1260266 D 5061 CDS An01g05300 4977657 join(1262847..1263029,1263379..1263520,1263571..1263614,1263668..1264480,1264530..>1265586) II 1 NT_166518.1 Function: S. pombe TAF72 is a subunit of the RNA-pol II transcription factor TFIID and is required for activated but not basal transcription.; Remark: a putative sequencing error was corrected by introducing a frameshift of 1 bp.; Remark: a series of deletion mutants of S. pombe TAF72 revealed that the most evolutionarily conserved regions, including the WD40 repeats, are in fact indispensable for viability.; Title: strong similarity to subunit of transcription initiation factor TFIID taf72p - Schizosaccharomyces pombe [putative frameshift]; nucleus; putative frameshift; See PMID 10721692; See PMID 9224658; uncharacterized protein 1265586 4977657 An01g05300 Aspergillus niger uncharacterized protein XP_059603151.1 1262847 D 5061 CDS An01g05310 4977183 complement(join(1265953..1266167,1266267..1266520,1266583..1266673,1266735..1266954,1266976..1267240,1267318..1267505)) II 1 NT_166518.1 Function: overexpression of S. cerevisiae PPE1 yields phenotypes similar to those observed after inactivation of the regulatory PP2A subunits B and B'.; Function: phosphoprotein phosphatase 2A (PP2A) catalytic subunit contains a methyl ester on its C-terminus which in S. cerevisiae is removed by the specific carboxyl methylesterase PPE1.; Remark: in the PIR protein database S. cerevisiae PPE1 has erronously been annotated as the S. cerevisiae mitochondrial ribosomal protein YmS2.; Title: strong similarity to protein phosphatase methylesterase Ppe1 - Saccharomyces cerevisiae; See PMID 11060018; uncharacterized protein 1267505 4977183 An01g05310 Aspergillus niger uncharacterized protein XP_059603152.1 1265953 R 5061 CDS An01g05320 4977980 join(1268607..1268759,1268820..1270241) II 1 NT_166518.1 Title: strong similarity to hypothetical protein SPAC23C11.06c - Schizosaccharomyces pombe; uncharacterized protein 1270241 4977980 An01g05320 Aspergillus niger uncharacterized protein XP_001388957.1 1268607 D 5061 CDS An01g05330 4977477 complement(join(1270974..1271270,1271349..1272649,1272686..1272822,1272911..1273041,1273109..1273207)) II 1 NT_166518.1 Function: S. cerevisiae NPL4 is required for nuclear export and import of proteins and RNA.; Localization: S. cerevisiae NPL4 is located at the nuclear periphery and localizes in a pattern similar to nuclear pore complex proteins.; Title: strong similarity to nuclear transport regulator Npl4 - Saccharomyces cerevisiae; nucleus; See PMID 8930904; uncharacterized protein 1273207 4977477 An01g05330 Aspergillus niger uncharacterized protein XP_059603153.1 1270974 R 5061 CDS An01g05340 4977296 complement(join(1273932..1274033,1274107..1274503,1274567..1274652,1274727..1274753)) II 1 NT_166518.1 Catalytic activity: 1,4-benzoquinone reductases convert 1,2,4-trihydroxybenzene + NAD to hydroxybenzoquinone + NADH2.; Complex: P. chrysosporium qr forms a homomdimer.; Induction: expression of P. chrysosporium qr is induced by 2-dimethoxybenzoquinone, vanillic acid, or several other aromatic compounds.; Localization: a S. cerevisiae protein, Pst2p with strong similarity to the predicted A. niger protein has been identified as a protoplast secreted protein.; Remark: the IUPAC proposes EC 1. 6. 5. 7. for 1,4-benzoquinone reductases.; Title: strong similarity to 1,4-benzoquinone reductase qr - Phanerochaete chrysosporium; extracellular/secretion proteins; See PMID 9925562; uncharacterized protein 1274753 4977296 An01g05340 Aspergillus niger uncharacterized protein XP_001388959.3 1273932 R 5061 CDS An01g05350 4978357 complement(join(1275763..1275853,1275948..1276443,1276480..1276687)) II 1 NT_166518.1 Complex: S. cerevisiae Yth1p interacts with Fip1p,another component of the PF I.; Complex: S. cerevisiae Yth1p is a subunit of the polyadenylation factor I (PF I), a key component of the RNA 3'-end processing machinery.; Function: S. cerevisiae Yth1p binds RNA polymers with a distinct preference for poly(U).; Function: S. cerevisiae yth1 mutants have normal mRNA cleavage activity, but fail to polyadenylate the upstream cleavage product.; Remark: the systematic name for S. cerevisiae YTH1 is YPR107c.; Similarity: S. cerevisiae Yth1p contains five C3H-zinc-finger repeats and a putative RNA-binding zinc knuckle motif at the carboxyl terminus.; Title: strong similarity to RNA-binding polyadenylation factor I subunit Yth1 - Saccharomyces cerevisiae; nucleus; See PMID 10371034; See PMID 9224719; uncharacterized protein 1276687 4978357 An01g05350 Aspergillus niger uncharacterized protein XP_059603154.1 1275763 R 5061 CDS An01g05360 4978360 join(1279269..1279456,1279546..1279570,1279637..1279871,1280001..1280626) II 1 NT_166518.1 Catalytic activity: chitinases hydrolyse the 1,4-beta-linkages of N-acetyl-D-glucosamine polymers of chitin.; Title: strong similarity to 42 kDa endochitinase Tham-ch - Trichoderma hamatum; See PMID 9742695; uncharacterized protein 1280626 4978360 An01g05360 Aspergillus niger uncharacterized protein XP_001388961.3 1279269 D 5061 CDS An01g05370 4977574 complement(join(1281472..1281756,1281824..1281945,1282016..1282431,1282520..1282683)) II 1 NT_166518.1 Remark: a splice site upstream of the START-codon was detected.; Similarity: the ORF displays strong similarity to the A. niger EST an_2772.; Title: similarity to hypothetical protein encoded by An09g04380 - Aspergillus niger; uncharacterized protein 1282683 4977574 An01g05370 Aspergillus niger uncharacterized protein XP_001388962.1 1281472 R 5061 CDS An01g05380 84589950 join(1283504..1283653,1283737..1283769,1283815..1284061,1284347..1284465) II 1 NT_166518.1 hypothetical protein 1284465 84589950 An01g05380 Aspergillus niger hypothetical protein XP_059603155.1 1283504 D 5061 CDS An01g05390 4978476 complement(join(1285218..1285368,1285426..1287623)) II 1 NT_166518.1 Title: similarity to hypothetical protein YBR007c -Saccharomyces cerevisiae; uncharacterized protein 1287623 4978476 An01g05390 Aspergillus niger uncharacterized protein XP_059603156.1 1285218 R 5061 CDS An01g05400 4978040 join(1290619..1291080,1291159..1291560) II 1 NT_166518.1 Remark: the central region of the predicted A. niger protein shows weak similarity to small molecule binding proteins.; Title: weak similarity to hypothetical protein 6R55.1 - Caenorhabditis elegans; uncharacterized protein 1291560 4978040 An01g05400 Aspergillus niger uncharacterized protein XP_001388965.1 1290619 D 5061 CDS An01g05410 4977181 complement(join(1291954..1292796,1292856..1293019,1293072..1293414,1293477..1293509)) II 1 NT_166518.1 Title: strong similarity to hypothetical protein EAA65709.1 - Aspergillus nidulans; uncharacterized protein 1293509 4977181 An01g05410 Aspergillus niger uncharacterized protein XP_001388966.1 1291954 R 5061 CDS An01g05420 84589951 join(1293798..1293883,1293966..1294122,1294247..1294285) II 1 NT_166518.1 hypothetical protein 1294285 84589951 An01g05420 Aspergillus niger hypothetical protein XP_059603157.1 1293798 D 5061 CDS An01g05440 84589952 complement(join(1294687..1294908,1294952..1295101,1295347..1295469,1295516..1295566,1295659..1295739,1296040..1296071,1296156..1296276)) II 1 NT_166518.1 hypothetical protein 1296276 84589952 An01g05440 Aspergillus niger hypothetical protein XP_059603158.1 1294687 R 5061 CDS An01g05450 4977086 join(1296652..1296696,1296782..1296805,1296885..1297700) II 1 NT_166518.1 Function: Pho85p interacts with the cyclin Pcl1p/Hcs26p and Pcl2p to regulate cell cycle progression.; Function: Pho85p-Pho80p Cyclin CDK is required for negative regulation of Pho4p transcription factor in response to phosphate.; Function: cyclin-dependent protein kinase Pho85p interacts with the cyclin Pho80p.; Remark: Pho85 was originally discovered as a regulator of phosphate metabolism but roles for Pho85 in glycogen biosynthesis, actin regulation and cell cycle progression have since been discovered.; Remark: YPL031C is the systematic name for PHO85.; Title: strong similarity to cyclin-dependent protein kinase Pho85 - Saccharomyces cerevisiae; deleted EC_number 2.7.1.37; See PMID 10740818; See PMID 8108735; uncharacterized protein 1297700 4977086 An01g05450 Aspergillus niger uncharacterized protein XP_001388969.1 1296652 D 5061 CDS An01g05460 4977030 complement(join(1298947..1299351,1299440..1299472)) II 1 NT_166518.1 Title: strong similarity to hypothetical protein encoded by An11g00170 - Aspergillus niger; uncharacterized protein 1299472 4977030 An01g05460 Aspergillus niger uncharacterized protein XP_059603159.1 1298947 R 5061 CDS An01g05470 4977586 join(1300853..1301136,1301222..1302191) II 1 NT_166518.1 Title: strong similarity to hypothetical protein F14J16.17 - Arabidopsis thaliana; uncharacterized protein 1302191 4977586 An01g05470 Aspergillus niger uncharacterized protein XP_001388971.1 1300853 D 5061 CDS An01g05480 84589953 complement(join(1302424..1302797,1302859..1302889)) II 1 NT_166518.1 Title: similarity to hypothetical protein encoded by An06g00890 - Aspergillus niger; uncharacterized protein 1302889 84589953 An01g05480 Aspergillus niger uncharacterized protein XP_059603160.1 1302424 R 5061 CDS An01g05490 84589954 join(1303495..1303501,1303715..1303949,1304148..1304214) II 1 NT_166518.1 hypothetical protein 1304214 84589954 An01g05490 Aspergillus niger hypothetical protein XP_059603161.1 1303495 D 5061 CDS An01g05500 4978299 complement(join(1304847..1307463,1307535..1307789,1307856..1307872)) II 1 NT_166518.1 Title: strong similarity to hypothetical trp asp repeat protein - Schizosaccharomyces pombe; uncharacterized protein 1307872 4978299 An01g05500 Aspergillus niger uncharacterized protein XP_059603162.1 1304847 R 5061 CDS An01g05510 4977709 join(1308141..1308202,1308273..1308943,1308999..1309099,1309154..1309202,1309257..1309336) II 1 NT_166518.1 Complex: Arp2/3 complex 34 kD subunit belongs to a complex composed of arp2, arp3, p41-arc, p34-arc, p21-arc,p20-arc and p16-arc.; Function: Arp2/3 complex 34 kD subunit forms part of a complex implicated in the control of actin polymerization in cells.; Similarity: Arp2/3 complex 34 kD subunit shows strong similarity to other p34-arc subunits.; Title: strong similarity to GABA-A receptor epsilon-like subunit - Homo sapiens; cytoskeleton; See PMID 9230079; uncharacterized protein 1309336 4977709 An01g05510 Aspergillus niger uncharacterized protein XP_001388975.1 1308141 D 5061 CDS An01g05520 84589955 complement(join(1310268..1310531,1310622..1310833,1311110..1311205,1311307..1311439,1311511..1311564)) II 1 NT_166518.1 hypothetical protein 1311564 84589955 An01g05520 Aspergillus niger hypothetical protein XP_059603163.1 1310268 R 5061 CDS An01g05530 4978080 join(1311699..1312691,1312753..1312899) II 1 NT_166518.1 hypothetical protein 1312899 4978080 An01g05530 Aspergillus niger hypothetical protein XP_001388977.3 1311699 D 5061 CDS An01g05540 10098153 join(1313662..1313931,1314003..1314206,1314278..1315002,1315674..1315799,1315952..1316614,1316729..1317393,1317444..1317496) II 1 NT_166518.1 Title: similarity to hypothetical protein T27E13.9 -Arabidopsis thaliana; uncharacterized protein 1317496 10098153 An01g05540 Aspergillus niger uncharacterized protein XP_003188553.2 1313662 D 5061 CDS An01g05560 4978287 join(1318365..1318452,1318531..1318620,1318685..1318937,1319022..1319490) II 1 NT_166518.1 Title: similarity to hypothetical protein SPCC18.12c - Schizosaccharomyces pombe; uncharacterized protein 1319490 4978287 An01g05560 Aspergillus niger uncharacterized protein XP_059603164.1 1318365 D 5061 CDS An01g05570 4977314 complement(join(1319843..1320120,1320205..1320238)) II 1 NT_166518.1 Title: similarity to hypothetical protein SPBC21D10.07 - Schizosaccharomyces pombe; uncharacterized protein 1320238 4977314 An01g05570 Aspergillus niger uncharacterized protein XP_001388980.1 1319843 R 5061 CDS An01g05580 4977403 1320660..>1320846 II 1 NT_166518.1 Remark: the ORF encoded protein is C-terminally truncated due to the contig border.; Title: similarity to hypothetical periodic tryptophan protein Pwp1 - Saccharomyces cerevisiae [truncated ORF]; uncharacterized protein 1320846 4977403 An01g05580 Aspergillus niger uncharacterized protein XP_001388981.3 1320660 D 5061 CDS An01g05590 84589956 join(1323907..1323935,1324261..1324999) II 1 NT_166518.1 Title: strong similarity to EST an_3161 -Aspergillus niger; uncharacterized protein 1324999 84589956 An01g05590 Aspergillus niger uncharacterized protein XP_059603165.1 1323907 D 5061 CDS An01g05600 84589957 1325404..1326147 II 1 NT_166518.1 hypothetical protein 1326147 84589957 An01g05600 Aspergillus niger hypothetical protein XP_059603166.1 1325404 D 5061 CDS An01g05610 4978333 join(1327184..1329037,1329095..1329316) II 1 NT_166518.1 Complex: human RRN3 interacts directly with TAF(I)110 and TAF(I)63 of promoter-selectivity factor SL1.; Function: human RRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters.; Function: human RRN3 mediates growth-dependent control of ribosomal RNA synthesis.; Remark: an alternative name for human RRN3 is TIF-IA.; Title: strong similarity to RNA polymerase I transcription factor RRN3 - Homo sapiens; nucleus; See PMID 10758157; See PMID 11250903; See PMID 11265758; uncharacterized protein 1329316 4978333 An01g05610 Aspergillus niger uncharacterized protein XP_059603167.1 1327184 D 5061 CDS An01g05620 4978515 complement(join(1329841..1329853,1329940..1330042,1330446..1330905,1331047..1331520)) II 1 NT_166518.1 Function: Pseudomanas sp. lipP has a 1,3-positional specificity toward triolein and uses p-Nitrophenyl esters of fatty acids with short to medium chains (C4 and C6) as substrate.; Title: strong similarity to lipase LipP -Pseudomonas sp.; See PMID 9464382; uncharacterized protein 1331520 4978515 An01g05620 Aspergillus niger uncharacterized protein XP_059603168.1 1329841 R 5061 CDS An01g05630 4978498 1332478..1335336 II 1 NT_166518.1 Remark: the single exon of the predicted A. niger protein shows strong similarity to several aspartate-tRNA ligases, which are general about 400 aa shorter.; Title: strong similarity to cytoplasmic aspartate--tRNA ligase Aps - Saccharomyces cerevisiae; cytoplasm; uncharacterized protein 1335336 4978498 An01g05630 Aspergillus niger uncharacterized protein XP_001388986.1 1332478 D 5061 CDS An01g05640 4978503 complement(join(1335871..1336389,1336451..1336777)) II 1 NT_166518.1 Remark: the ORF shows local similarity to the hypothetical protein B17C10. 270 of N. crassa: only 41 amino acids are included in the alignment.; Title: similarity to hypothetical protein B17C10.270 - Neurospora crassa; uncharacterized protein 1336777 4978503 An01g05640 Aspergillus niger uncharacterized protein XP_001388987.1 1335871 R 5061 CDS An01g05650 4978024 join(1337696..1337720,1337796..1337836,1337957..1337983,1338077..1338152,1338235..1339189,1339259..1339481) II 1 NT_166518.1 Phenotype: a tubA mutation (tubA4) causes supersensitivity to benomyl during vegetative growth.; Remark: A. nidulans possesses 2 tubulin genes: tubB is required for sexual development and tubA is required during vegetative growth for mitosis and nuclear migration.; Remark: tubA of A. nidulans belongs to the tubulin family.; Remark: tubulin is the major component of microtubules.; Title: strong similarity to tubulin alpha-1 chain tubA - Aspergillus nidulans; See PMID 8336695; See PMID 8601474; See PMID 1672037; uncharacterized protein 1339481 4978024 An01g05650 Aspergillus niger uncharacterized protein XP_001388988.1 1337696 D 5061 CDS An01g05660 4978426 join(1340664..1340676,1340808..1340962,1341057..1341180,1341270..1341448,1341481..1344849,1344904..1344933) II 1 NT_166518.1 Localization: Ede1 of S. cerevisiae is localized in punctate cortical spots that only partially colocalize with actin patches.; Phenotype: deletion of Ede1 of S. cerevisiae impairs the diploid budding pattern, but has only a small impact on actin cytoskeleton organization.; Phenotype: deletion of Ede1 of S. cerevisiae leads to a defective fluid-phase endocytosis and to defective internalization of the pheromone (alpha)-factor and uracil permease.; Remark: Ede1 of S. cerevisiae belongs to the VDP/uso1/YBL047c family.; Remark: Ede1 of S. cerevisiae is also called YBL047c and YBL0520.; Remark: the ORF overlaps C-terminally with the A. niger EST an_3336 in EMBLEST:BE759046.; Similarity: the ORF shows additionally similarity to other proteins containing an EH domain, like epithermal growth factor receptor substrates.; Similarity: the ORF shows local strong similarity to Ede1 of S. cerevisiae: the proteins overlap in the N-terminal half.; Title: strong similarity to endocytosis protein Ede1 - Saccharomyces cerevisiae; See PMID 10954428; uncharacterized protein 1344933 4978426 An01g05660 Aspergillus niger uncharacterized protein XP_059603169.1 1340664 D 5061 CDS An01g05670 4977068 complement(join(1345923..1346101,1346191..1348288,1348342..1348572,1348639..1349019)) II 1 NT_166518.1 Function: Pma1 of S. cerevisiae is a hydrogen ion pump, the proton gradient generated by the enzyme drives the active transport of nutrients by H+-symport.; Induction: expression of Pma1 of S. cerevisiae is strongly stimulated during growth adaption under high copper stress, presumably triggered by the resulting intracellular acidification. This physiological response may allow the cells to cope with copper-induced lipid peroxidation and consequent decrease in plasma membrane lipid ordering and increase in the non-specific permeability to protons.; Phenotype: null mutation of Pma1 of S. cerevisiae is lethal in haploid cells.; Remark: Pma1 of S. cerevisiae is also called G3737 andYGL008c.; Title: strong similarity to H+-transporting ATPase Pma1 - Saccharomyces cerevisiae; plasma membrane; See PMID 11284007; See PMID 11481477; See PMID 3005867; uncharacterized protein 1349019 4977068 An01g05670 Aspergillus niger uncharacterized protein XP_059603170.1 1345923 R 5061 CDS An01g05680 4977445 join(1350022..1350052,1350108..1350211,1350264..1350525,1350582..1350612,1350911..1351008,1351101..1351495,1351584..1351749,1351784..1351821) II 1 NT_166518.1 Similarity: the ORF is 250 amino acids shorter than B1D1. 200 of N. crassa.; Similarity: the ORF shows local strong similarity to B1D1. 200 of N. crassa: only 71 N-terminal amino acids are included in the alignment.; Title: similarity to hypothetical myocyte-specific enhancer factor 2d related protein B1D1.200 - Neurospora crassa; uncharacterized protein 1351821 4977445 An01g05680 Aspergillus niger uncharacterized protein XP_059603171.1 1350022 D 5061 CDS An01g05690 4978345 complement(join(1352235..1353392,1353461..1353847,1353928..1354014)) II 1 NT_166518.1 Complex: orc5 is one of the six subunits of ORC.; Function: ORC is important for chromosomal replication and mating type transcriptional silencing.; Function: orc5 of S. pombe is a part of the origin recognition complex (ORC) that binds to DNA origins.; Remark: orc5 of S. pombe belongs to the orc5 family.; Similarity: the ORF is 113 amino acids longer than orc5 of S. pombe, however, due to gap introduction, the complete orc5 and ORF sequences are aligned.; Title: strong similarity to origin recognition complex subunit 5 orc5p - Schizosaccharomyces pombe; See PMID 10535928; uncharacterized protein 1354014 4978345 An01g05690 Aspergillus niger uncharacterized protein XP_001388992.1 1352235 R 5061 CDS An01g05700 4978192 complement(join(1355071..1356167,1356225..1357262,1357295..1357457)) II 1 NT_166518.1 Function: pumilio of X. laevis binds cyclin B1 mRNA and interacts with Xcat-2 (a Nanos homolog) and CPEB (a key regulator of translational repression and activation of mRNAs stored in oocytes).; Remark: pumilio is a translational repressor by binding to the 3' UTR of mRNA and thereby involved in developmental regulation.; Remark: the ORF is 189 amino acids longer than pumilio of X. laevis, in the alignment between the two proteins about 100 N- and C-terminal amino acids of the ORF are lacking.; Title: strong similarity to cyclin B1 mRNA-binding protein pumilio - Xenopus laevis; See PMID 11283000; See PMID 11441171; uncharacterized protein 1357457 4978192 An01g05700 Aspergillus niger uncharacterized protein XP_059603172.1 1355071 R 5061 CDS An01g05710 84589958 complement(join(1357767..1358201,1358503..1358781)) II 1 NT_166518.1 Title: similarity to hypothetical protein CAD21190.1 - Neurospora crassa; uncharacterized protein 1358781 84589958 An01g05710 Aspergillus niger uncharacterized protein XP_059603173.1 1357767 R 5061 CDS An01g05717 84589959 1362980..1363252 II 1 NT_166518.1 hypothetical protein 1363252 84589959 An01g05717 Aspergillus niger hypothetical protein XP_059603174.1 1362980 D 5061 CDS An01g05720 84589960 complement(join(1363896..1364024,1364083..1364209,1364604..1364719)) II 1 NT_166518.1 Remark: the ORF's intron/exon structure is unusual for A. niger and the ORF is short in length (123 amino acids).; Title: questionable ORF; uncharacterized protein 1364719 84589960 An01g05720 Aspergillus niger uncharacterized protein XP_059603175.1 1363896 R 5061 CDS An01g05730 84589961 join(1366584..1366891,1366999..1367301,1367362..1367635,1367675..1367869,1367921..>1368525) II 1 NT_166518.1 Function: OsMST3 of O. sativa has transport activity for some monosaccharides in an energy-dependent H+ co-transport manner.; Function: OsMST3 of O. sativa is involved in the accumulation of monosaccharides required for cell wall synthesis at the stage of cell thickening.; Remark: 100 N-terminal amino acids of the ORF are lacking in the alignment with OsMST3 of O. sativa.; Remark: a putative frameshift results in an premature STOP codon.; Title: strong similarity to monosaccharide transporter 3 OsMST3 - Oryza sativa [putative frameshift]; putative frameshift; See PMID 11038054; uncharacterized protein 1368525 84589961 An01g05730 Aspergillus niger uncharacterized protein XP_059603176.1 1366584 D 5061 CDS An01g05740 4978085 join(1368898..1368964,1369036..1369831,1369888..1372702) II 1 NT_166518.1 Catalytic activity: RNA polymerase III catalyses DNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time.; Complex: RP128 of D. melanogaster is the second largest chain of RNA polymerase III.; Function: DNA-dependent RNA polymerase III transcribes DNA encoding tRNA and 5S RNA genes into RNA.; Remark: RP128 of D. melanogaster belongs to the RNA polymerase beta-chain family.; Title: strong similarity to 132 kD subunit of DNA-directed RNA polymerase III RP128 - Drosophila melanogaster; nucleus; See PMID 1910149; uncharacterized protein 1372702 4978085 An01g05740 Aspergillus niger uncharacterized protein XP_059603177.1 1368898 D 5061 CDS An01g05750 4977672 complement(1373012..1373899) II 1 NT_166518.1 Title: similarity to hypothetical indole-diterpene gene cluster protein paxU - Penicillium paxilli; See PMID 11169115; uncharacterized protein 1373899 4977672 An01g05750 Aspergillus niger uncharacterized protein XP_001388999.1 1373012 R 5061 CDS An01g05760 4977911 complement(join(1374548..1375330,1375389..1375703,1375771..1375773)) II 1 NT_166518.1 Function: UFD1 of S. cerevisiae functions at a post-ubiquitination step in the ubiquitin fusion degradation (UFD) pathway.; Function: furthermore UFD1 of S. cerevisiae interacts with the poly(A) polymerase and thereby affects polyadenylation.; Remark: UFD1 of S. cerevisiae is also called G4318 and YGR048w.; Remark: ubiquitination marks a protein for degradation.; Title: strong similarity to ubiquitin fusion degradation protein Ufd1 - Saccharomyces cerevisiae; See PMID 9236779; See PMID 7615550; uncharacterized protein 1375773 4977911 An01g05760 Aspergillus niger uncharacterized protein XP_001389000.1 1374548 R 5061 CDS An01g05770 4978330 1376154..1377509 II 1 NT_166518.1 Function: CD2BP of H. sapiens binds a cytoplamic region of CD2.; Remark: CD2 is a T cell surface antigen, recognizing LFA-3 on antigen-presenting cells.; Remark: overexpression of CD2BP of H. sapiens enhances IL-2 production by crosslinking of CD2 but not of the T cell receptor.; Similarity: the ORF is 110 amino acids longer than CD2BP of H. sapiens, the alignment between the two proteins lacks about 100 N-terminal amino acids of the ORF.; Title: similarity to CD2 binding protein CD2BP -Homo sapiens; See PMID 9843987; See PMID 10404223; uncharacterized protein 1377509 4978330 An01g05770 Aspergillus niger uncharacterized protein XP_001389001.1 1376154 D 5061 CDS An01g05780 4978429 complement(join(1377828..1378781,1378843..1379289,1379348..1379356)) II 1 NT_166518.1 Function: Tih2 of S. cerevisiae is required for vegetative cell growth and localizes in the nucleus.; Function: furthermore, Tih2 of S. cerevisiae is required for transcription of G(1) cyclin and of several ribosomal protein genes.; Remark: Tih2 of S. cerevisiae is also called YPL235w or P1060.; Remark: Tih2 of S. cerevisiae may be involved in the regulation of RNA polymerase II-directed transcription.; Remark: Tih2 of S. cerevisiae tightly interacts with Tih1, which has been shown to interact with the TATA-binding protein and the RNA polymerase II holoenzyme complex.; Title: strong similarity to RuvB-like protein Tih2 -Saccharomyces cerevisiae; See PMID 10787406; uncharacterized protein 1379356 4978429 An01g05780 Aspergillus niger uncharacterized protein XP_001389002.1 1377828 R 5061 CDS An01g05790 4978473 1379991..1382813 II 1 NT_166518.1 Function: uso1 of S. cerevisiae is required for intracellular protein transport in S. cerevisiae, probably the protein transport from the ER to the later secretory compartments.; Phenotype: uso1 mutant S. cerevisiae strains were blocked in the protein secretion pathway and are not able to induce sexual aggregation.; Similarity: the ORF is 835 amino acids shorter at the C-terminus than uso1 of S. cerevisiae; the similarity is restricted to the C-terminal part, which is probably dispensable for the protein function.; Similarity: the ORF shows similarity to myosin heavy chains from some species.; Title: similarity to transport protein Uso1 -Saccharomyces cerevisiae; See PMID 2373371; See PMID 2715179; uncharacterized protein 1382813 4978473 An01g05790 Aspergillus niger uncharacterized protein XP_001389003.1 1379991 D 5061 CDS An01g05800 4977104 complement(join(1383210..1383241,1383311..1383614,1383687..1383882,1384004..1384128,1384199..1384238,1384317..1384510)) II 1 NT_166518.1 Function: estf1 of P. fluorescens shows highest activity towards lactones and significantly lower activity towards aliphatic esters with the exception of ethyl caprylate.; Localization: estf1 of P. fluorescens is membrane bound or membrane associated.; Similarity: the ORF shows local similarity to estf1 of P. fluorescens: only the N-terminal half is included in the alignment.; Similarity: the ORF shows strong similarity to the hypothetical abhydrolase (SPAC22H12. 03) of S. cerevisiae.; Title: similarity to lactone-specific esterase estf1 - Pseudomonas fluorescens; See PMID 9925571; uncharacterized protein 1384510 4977104 An01g05800 Aspergillus niger uncharacterized protein XP_001389004.1 1383210 R 5061 CDS An01g05810 4977742 complement(join(1385444..1385617,1385706..1385755,1385826..1385958)) II 1 NT_166518.1 Title: strong similarity to hypothetical protein CAE85516.1 - Neurospora crassa; uncharacterized protein 1385958 4977742 An01g05810 Aspergillus niger uncharacterized protein XP_001389005.1 1385444 R 5061 CDS An01g05820 4977384 join(1386487..1386514,1386565..1386803,1386871..1387186,1387254..1387350,1387417..1387624) II 1 NT_166518.1 Pathway: hpcE of E. coli is part of the homoprotocatechuate (HPC; 3,4-dihydroxyphenylacetate) degradative operon.; Remark: homoprotocatechuate is catabolized to Krebs cycle intermediates and part of the tyrosine metabolism.; Remark: hpcE of E. coli encodes two functionalities: the 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (EC 5. 3. 3. -) and the 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase (EC 4. 1. 1. -).; Similarity: the C-terminal part of the ORF (35 amino acids) and 154 N-terminal amino acids of hpcE are not included in the alignment between the two proteins.; Similarity: the ORF is 110 amino acids shorter than hpcE of E. coli.; Title: strong similarity to homoprotocatechuate operon enzyme hpcE - Escherichia coli; See PMID 8223600; See PMID 8384293; uncharacterized protein 1387624 4977384 An01g05820 Aspergillus niger uncharacterized protein XP_001389006.1 1386487 D 5061 CDS An01g05830 4977546 complement(join(1389386..1389664,1389741..1390256,1390331..1390497,1390549..1390793,1390848..1390930,1391019..1391243)) II 1 NT_166518.1 Function: the drug transporter CYHR of C. maltosa mediates resistance to cycloheximide.; Similarity: only the N-terminal parts of the two proteins (ORF and CYHR of C. maltosa) are aligned.; Similarity: the ORF shows similarity to several MDR proteins from different species.; Title: strong similarity to cycloheximide resistance protein CYHR - Candida maltosa; See PMID 1628836; uncharacterized protein 1391243 4977546 An01g05830 Aspergillus niger uncharacterized protein XP_059603178.1 1389386 R 5061 CDS An01g05840 4978213 complement(<1392895..1393770) II 1 NT_166518.1 Remark: C-terminally truncated ORF due to contig border.; Similarity: the central part of the predicted ORF shows some weak and partial similarity to a novel human DNA binding protein called GLUT4 enhancer factor.; hypothetical protein [truncated ORF] 1393770 4978213 An01g05840 Aspergillus niger hypothetical protein [truncated ORF] XP_001389008.3 1392895 R 5061 CDS An01g05850 4978265 join(1394809..1394847,1394952..1395223,1395287..1395827,1395896..1396144) II 1 NT_166518.1 Remark: in A. nidulans, the gene is adjacent to sncB, a suppressor of the nudC mutation.; Title: strong similarity to hypothetical protein AAB38299.1 - Aspergillus nidulans; See PMID 8647384; uncharacterized protein 1396144 4978265 An01g05850 Aspergillus niger uncharacterized protein XP_059599669.1 1394809 D 5061 CDS An01g05860 4978158 complement(join(1396980..1397774,1397824..1397898)) II 1 NT_166518.1 Similarity: other BLASTP matches are mainly due to poly-Ser stretches.; Title: weak similarity to hypothetical secreted antigen SagBb - Enterococcus hirae; uncharacterized protein 1397898 4978158 An01g05860 Aspergillus niger uncharacterized protein XP_001389010.1 1396980 R 5061 CDS An01g05870 84589962 complement(join(1398070..1398409,1398507..1398810,1398892..1398973)) II 1 NT_166518.1 hypothetical protein 1398973 84589962 An01g05870 Aspergillus niger hypothetical protein XP_059599670.1 1398070 R 5061 CDS An01g05880 4977173 join(1399091..1399120,1399362..1399428,1399511..1400145) II 1 NT_166518.1 Similarity: the predicted ORF shows a partial and weak similarity to the C-terminal region of the B. taurus neurofilament-M subunit.; Title: similarity to hypothetical protein encoded by An11g00170 - Aspergillus niger; uncharacterized protein 1400145 4977173 An01g05880 Aspergillus niger uncharacterized protein XP_001389012.1 1399091 D 5061 CDS An01g05890 4977523 complement(join(1400539..1400981,1401050..1401122,1401189..1401224)) II 1 NT_166518.1 Similarity: Dof2 of Z. mais was identified due to the presence of a putative DNA binding motif, called Dof domain; Dof2 has no known function.; Similarity: the predicted ORF is very rich in low complexity regions, and the BLASTP hits are mainly due to repetitive elements.; Title: weak similarity to hypothetical DNA-binding protein Dof2 - Zea mays; See PMID 7567449; uncharacterized protein 1401224 4977523 An01g05890 Aspergillus niger uncharacterized protein XP_001389013.1 1400539 R 5061 CDS An01g05900 4978074 complement(join(1401696..1401858,1401904..1402067,1402120..1402204,1402261..1402286,1402338..1402658,1402706..1403244,1403315..1403531)) II 1 NT_166518.1 Function: CYP58 of F. sporotrichioides is encoded by the Tri4 gene and is involved in trichothecene biosynthesis.; Function: due to the extreme variety of substrates and reactions catalyzed, it is difficult to assess substrate specificity by homology comparison.; Remark: trichothecenes are sesquiterpenoid toxins that act by inhibiting protein biosynthesis.; Similarity: the protein shows strong similarity to the large superfamily of P450 cytochromes, which are heme-thiolate proteins acting as terminal oxidase in multicomponent electron transfer chains.; Title: strong similarity to cytochrome P450 trichodiene oxygenase TRI4 - Fusarium sporotrichioides; See PMID 7651333; uncharacterized protein 1403531 4978074 An01g05900 Aspergillus niger uncharacterized protein XP_001389014.1 1401696 R 5061 CDS An01g05910 84589963 join(1403731..1403787,1403860..1404165,1404238..1404337,1404432..1404479,1404592..1404722) II 1 NT_166518.1 hypothetical protein 1404722 84589963 An01g05910 Aspergillus niger hypothetical protein XP_059599671.1 1403731 D 5061 CDS An01g05920 4978388 complement(join(1405138..1405186,1405216..1405277,1405475..1405811,1405868..1406077,1406137..1406177,1406245..1406311,1406361..1406402,1406459..1406551,1406604..1406650,1406718..1406867)) II 1 NT_166518.1 Title: strong similarity to hypothetical methyltransferase AAO34671.1 - Gibberella zeae; uncharacterized protein 1406867 4978388 An01g05920 Aspergillus niger uncharacterized protein XP_059599672.1 1405138 R 5061 CDS An01g05930 84589964 complement(join(1408223..1408474,1408715..1408777)) II 1 NT_166518.1 hypothetical protein 1408777 84589964 An01g05930 Aspergillus niger hypothetical protein XP_059599673.1 1408223 R 5061 CDS An01g05940 84589965 join(1409200..1409324,1409645..1409715,1410037..1410182) II 1 NT_166518.1 hypothetical protein 1410182 84589965 An01g05940 Aspergillus niger hypothetical protein XP_059599674.1 1409200 D 5061 CDS An01g05955 84589966 1411009..1411410 II 1 NT_166518.1 hypothetical protein 1411410 84589966 An01g05955 Aspergillus niger hypothetical protein XP_059599675.1 1411009 D 5061 CDS An01g05960 4978146 join(1411852..1411984,1412067..1412269) II 1 NT_166518.1 Function: CV-N of N. ellipsosporum binds with extremely high affinity to highly conserved binding site(s) on the viral envelope glycoprotein gp120, preventing virus-to-cell fusion, viral entry and infection of cells.; Function: cyanovirin-N of N. ellipsosporum is a potent HIV (human immunodeficiency virus)-inactivating protein.; Remark: cyanovirin-N of N. ellipsosporum has been patented under Patent N. WO9634107-A2.; Similarity: the predicted ORF is identical to several A. niger ESTs (e. g. EMBL EST Acc. BE760612,BE758894).; Title: similarity to cyanovirin-N CV-N - Nostoc ellipsosporum; See PMID 9299483; See PMID 10794101; uncharacterized protein 1412269 4978146 An01g05960 Aspergillus niger uncharacterized protein XP_001389020.1 1411852 D 5061 CDS An01g05970 4978232 complement(1412664..1414787) II 1 NT_166518.1 Title: similarity to hypothetical protein CAD70385.1 - Neurospora crassa; uncharacterized protein 1414787 4978232 An01g05970 Aspergillus niger uncharacterized protein XP_059599676.1 1412664 R 5061 CDS An01g05980 84589967 complement(join(1415079..1415301,1415436..1415565,1415658..1415702,1415780..1415846)) II 1 NT_166518.1 hypothetical protein 1415846 84589967 An01g05980 Aspergillus niger hypothetical protein XP_059599677.1 1415079 R 5061 CDS An01g05990 4978272 join(1415983..1416663,1416723..1418417) II 1 NT_166518.1 Function: abp2 of S. pombe binds the ARS (autonomously replicating sequence) element ars3002 on chromosome III.; Localization: abp2 of S. pombe is likely located within the nucleus.; Phenotype: disruption of the abp2 gene in S. pombe showed that the gene is not essential for cell viability,however the null mutant was hypersensitive to DNA damage,suggesting that abp2 may play a role in regulating the cell cycle response to stress signals.; Remark: N-terminus might be about 100 amino acids shorter due to repetitive elements and weaker homology.; Similarity: abp2 of S. pombe contains a region similar to a proline-rich motif (GRP) present in several proteins that bind A+T-rich DNA sequences, and experimentally proven to be important for the DNA binding activity.; Title: similarity to ARS binding protein 2 abp2p -Schizosaccharomyces pombe; See PMID 9488484; uncharacterized protein 1418417 4978272 An01g05990 Aspergillus niger uncharacterized protein XP_001389023.1 1415983 D 5061 CDS An01g06000 4977939 complement(join(1418577..1418714,1419018..1419456,1419583..1419635,1419696..1419794)) II 1 NT_166518.1 Function: SigA of C. glutamicum encodes one principal sigma factor of the unique bacterial RNA polymerase.; Similarity: BLASTP detects comparable similarities with proteins having different functions and cellular localizations.; Similarity: domain structures functionally characterizing the various similar proteins are not conserved in the predicted ORF.; Similarity: strong similarity to hypothetical protein B7J19. 40 of Neurospora crassa.; Title: similarity to sigma factor SigA -Corynebacterium glutamicum; See PMID 8550480; uncharacterized protein 1419794 4977939 An01g06000 Aspergillus niger uncharacterized protein XP_001389024.3 1418577 R 5061 CDS An01g06010 4978047 complement(join(1420569..1421012,1421071..1421187)) II 1 NT_166518.1 Title: weak similarity to chromosomal protein D1 -Drosophila melanogaster; See PMID 2542275; uncharacterized protein 1421187 4978047 An01g06010 Aspergillus niger uncharacterized protein XP_001389025.1 1420569 R 5061 CDS An01g06020 4978015 complement(join(1421762..1422397,1422449..1422630,1422698..1422752)) II 1 NT_166518.1 Similarity: BLASTP detects several other unrelated similar proteins due to a polyglutamine stretch in the C-terminus.; Title: similarity to hypothetical protein B7J19.160 - Neurospora crassa; uncharacterized protein 1422752 4978015 An01g06020 Aspergillus niger uncharacterized protein XP_001389026.1 1421762 R 5061 CDS An01g06030 4977389 join(1424172..1424218,1424278..1424428,1424462..1424671,1424735..1424893,1424949..1425010,1425065..1425175,1425270..1425379,1425515..1425609) II 1 NT_166518.1 Catalytic activity: D-sorbose, D-agatose and 5-dehydro-D-fructose also act as acceptors in the previous reaction.; Catalytic activity: khk of H. sapiens catalyzes the reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate.; Pathway: khk of H. sapiens is involved in the fructose and mannose primary metabolism.; Phenotype: defects in khk in H. sapiens are the cause of fructosuria, a benign disease of intermediary metabolism.; Remark: in H. sapiens two forms (a and c) of khk are produced by alternative splicing.; Remark: khk of H. sapiens requires potassium.; Repression: khk of H. sapiens is inhibited by ADP.; Similarity: the predicted ORF shows weaker similarities with some ribokinases, suggesting that the substrate specificity might also be different.; Title: strong similarity to ketohexokinase khk -Homo sapiens; See PMID 7833921; See PMID 9799106; See PMID 2996495; uncharacterized protein 1425609 4977389 An01g06030 Aspergillus niger uncharacterized protein XP_059599678.1 1424172 D 5061 CDS An01g06040 4977741 join(1425872..1426104,1426182..1427025) II 1 NT_166518.1 Localization: the membrane localization suggested by the title is very questionable.; Title: strong similarity to hypothetical membrane protein YOL077c - Saccharomyces cerevisiae; uncharacterized protein 1427025 4977741 An01g06040 Aspergillus niger uncharacterized protein XP_001389028.1 1425872 D 5061 CDS An01g06050 4977745 1427967..1428962 II 1 NT_166518.1 Similarity: the predicted ORF shows a weak and partial similarity to an ABC transporter protein of S. aureus, patentnumber WO9950418-A1.; hypothetical protein 1428962 4977745 An01g06050 Aspergillus niger hypothetical protein XP_001389029.3 1427967 D 5061 CDS An01g06060 4977176 complement(join(1430819..1430949,1431019..1431099,1431160..1431549,1431660..1431672,1431742..1431762)) II 1 NT_166518.1 Function: rab11 of R. norvegicus influences endosome to TGN vesicular trafficking.; Localization: small GTP binding proteins of the rab family are associated with the cytoplasmic surface of compartments of the central vacuolar system.; Similarity: rab11 of R. norvegicus belongs to the ras transforming protein superfamily, and more precisely to the rab family of small GTP binding proteins.; Similarity: the gene model is strongly supported by local identity to several EST clones, in particular A. niger EMBLEST Acc. BE758911 and BE759254.; Similarity: the predicted ORF shows strong similarities with other members of the rab family identified in plants and fungi.; Title: strong similarity to GTP-binding protein rab11 - Rattus norvegicus; intracellular transport vesicles; See PMID 10332741; See PMID 11121436; See PMID 1711847; uncharacterized protein 1431762 4977176 An01g06060 Aspergillus niger uncharacterized protein XP_001389030.1 1430819 R 5061 CDS An01g06070 4977365 join(1432622..1433764,1433820..1434857,1434914..1435245,1435310..1435922) II 1 NT_166518.1 Remark: chp1 of S. pombe is also called SPAC18G6. 02c.; Similarity: chjp1 of S. pombe contains a chromo (chromatin organisation modifier) domain and is required for centromere function.; Similarity: part of the predicted ORF is identical to A. niger EST EMBLEST Acc. BE758993.; Similarity: the similarity with CHP1 of S. pombe is limited to the N-terminal tenth of the predicted ORF.; Title: weak similarity to chromo domain protein 1 chp1p - Schizosaccharomyces pombe; See PMID 9722643; uncharacterized protein 1435922 4977365 An01g06070 Aspergillus niger uncharacterized protein XP_059599679.1 1432622 D 5061 CDS An01g06080 4977049 complement(join(1436504..1437144,1437232..1437357,1437448..1437909,1437968..1438412)) II 1 NT_166518.1 Catalytic activity: ClpX of M. musculus has an ATPase activity.; Complex: ClpX of M. musculus is the regulatory subunit of a two component chaperone/protease complex; in this complex ClpX act as a chaperone molecule, while the protease subunit is called ClpP.; Function: the proposed function of the ClpX/ClpP complex in eukaryotic mitochondria is to exhert functions similar to the proteasome in this subcellular compartment.; Similarity: ClpX of M. musculus is a member of the Hsp100/Clp chaperone family, whose members participate in a broad range of biological processes in both prokaryotes and eukaryotes.; Similarity: in bacteria the ClpX/ClpP complex reveal a structural organization and a function homologous to that of the eukaryotic 26S proteasome.; Title: strong similarity to energy-dependent regulator of proteolysis ClpX - Mus musculus; localisation:mitochondrion; See PMID 10347188; uncharacterized protein 1438412 4977049 An01g06080 Aspergillus niger uncharacterized protein XP_059599680.1 1436504 R 5061 CDS An01g06090 84589968 join(1439035..1439048,1439059..1439123,1439137..1439258) II 1 NT_166518.1 Title: strong similarity to EST an_1250 -Aspergillus niger; uncharacterized protein 1439258 84589968 An01g06090 Aspergillus niger uncharacterized protein XP_059599681.1 1439035 D 5061 CDS An01g06100 84589969 complement(join(1439508..1440023,1440090..1440092)) II 1 NT_166518.1 Similarity: very weak similarity to a small fragment of spen, a D. melanogaster gene involved in development.; hypothetical protein 1440092 84589969 An01g06100 Aspergillus niger hypothetical protein XP_059599682.1 1439508 R 5061 CDS An01g06110 4978068 join(1440983..1441044,1441120..1441676,1441761..1442252,1442320..1442375) II 1 NT_166518.1 Catalytic activity: GPD1 of S. cerevisiae catalyzes the reaction: sn-glycerol 3-phosphate + NAD(+) <=> glycerone phosphate + NADH.; Function: as osmotic balance regulates cell fusion during mating in S. cerevisiae, a secondary effect of GDP1 mutations is an impairment of cell fusion.; Function: whereas GDP1 is mainly involved in osmoregulation, GDP2 is required to regulate metabolism under anoxic conditions, when glycerol formation is strictly required as a redox sink for excess cytosolic NADH.; Induction: expression of GPD1 of S. cerevisiae is induced by osmotic stress.; Remark: GPD1 of S. cerevisiae is produced with an N-terminal extension that is removed from the functional enzyme; this extension does not target GDP1 to any organelle.; Similarity: S. cerevisiae has a second glycerol-3-phosphate dehydrogenase called GPD2, which is 69% identical to GPD1.; Similarity: the predicted ORF belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.; Title: strong similarity to glycerol-3-phosphate dehydrogenase (NAD+) precursor Gpd1 - Saccharomyces cerevisiae; cytoplasm; See PMID 7934860; See PMID 8196651; See PMID 9171333; See PMID 9281576; See PMID 7476212; uncharacterized protein 1442375 4978068 An01g06110 Aspergillus niger uncharacterized protein XP_059599683.1 1440983 D 5061 CDS An01g06120 4977795 join(1443220..1443437,1443495..1447821,1447900..1447974) II 1 NT_166518.1 Catalytic activity: endohydrolysis of 1,6-alpha-D-glucoside linkages at points of branching in chains of 1,4-linked-alpha-D-glucose residues.; Catalytic activity: transfers a segment of a 1,4-alpha-D-glucan to a new position in an acceptor, which may be glucose or a 1,4-alpha-D-glucan.; Function: the glycogen debranching enzyme in mammals and yeast is involved both in the catabolism and in the biosynthesis of glycogen; its transferase activity is important for branching rearrangement.; Phenotype: in H. sapiens mutations of the glycogen debranching enzyme gene AGL cause a pathology known as glycogenosis type III.; Remark: GDB1 of S. cerevisiae is also known as YPR184w.; Remark: in H. sapiens the structure of the transcript of the AGL gene shows high degree of polymorphism, due to alternative transcription starts and alternative splicing, giving rise to different tissue-specific isoforms.; Similarity: 4-alpha-glucanotransferase / amylo-1,6-glucosidase is also called glycogen debranching enzyme, a bifunctional protein conserved from yeast to humans.; Title: strong similarity to 4-alpha-glucanotransferase / amylo-1,6-glucosidase Gdb1 -Saccharomyces cerevisiae; See PMID 8954797; See PMID 11094287; uncharacterized protein 1447974 4977795 An01g06120 Aspergillus niger uncharacterized protein XP_001389036.3 1443220 D 5061 CDS An01g06130 84589970 join(1448524..1448694,1448755..1448919,1448997..1450170,1450227..1451230) II 1 NT_166518.1 Title: strong similarity to hypothetical membrane protein YLR241w - Saccharomyces cerevisiae; uncharacterized protein 1451230 84589970 An01g06130 Aspergillus niger uncharacterized protein XP_059599684.1 1448524 D 5061 CDS An01g06140 84589971 join(1451643..1451736,1451971..1452190,1452286..1452400,1452479..1452652,1452751..1452816) II 1 NT_166518.1 Complex: subunit II is one of the three major components of the complex of the respiratory chain that catalyzes the reduction of oxygen to water on the inner mitochondrial membrane.; Remark: due to their strong evolutionary conservation, cytochromes are often used for molecular phylogenetic comparison.; Remark: the COII gene of K. blattae is encoded by the mitochondrial genome.; Similarity: the predicted ORF shows weak similarity to a region of many cytochrome c oxidase subunits II of different fungal species.; Title: weak similarity to cytochrome c oxidase subunit II COII - Kluyveromyces blattae; See PMID 10826829; uncharacterized protein 1452816 84589971 An01g06140 Aspergillus niger uncharacterized protein XP_059599685.1 1451643 D 5061 CDS An01g06150 4978280 complement(join(1453353..1453522,1453598..1454503,1454575..1454629,1454698..1454703)) II 1 NT_166518.1 Catalytic activity: DAHP synthase catalyzes the condensation of erythrose-4-phosphate (E4P) and phosphoenolpyruvate (PEP) to yield DAHP (3-deoxy-D-arabino-heptulosonate-7-phosphate).; Cofactor: both aroG and aroF of A. nidulans are inhibited by the chelating agent EDTA, which indicates a metal ion as cofactor.; Function: DAHP synthases catalyze the first committed step of the shikimate pathway, which ultimately leads to the biosynthesis of folates, ubiquinone, aromatic amino acids, and derivatives.; Repression: aroG and aroF of A. nidulans are differentially regulated by phenylalanine and tyrosine,respectively.; Repression: phenylalanine is a competitive inhibitor of the isoenzyme aroG in its reaction with E4P (erythrose-4-phosphate).; Similarity: in A. nidulans two DAHP synthase isoenzymes exist, and are called aroG and aroF.; Title: strong similarity to phe-inhibited DAHP synthase aroG - Aspergillus nidulans; See PMID 11285739; uncharacterized protein 1454703 4978280 An01g06150 Aspergillus niger uncharacterized protein XP_001389039.1 1453353 R 5061 CDS An01g06160 84589972 complement(join(1455810..1458813,1458871..1458956,1459003..1459158,1459211..1459585)) II 1 NT_166518.1 Title: weak similarity to hypothetical ABC transporter - Schizosaccharomyces pombe; uncharacterized protein 1459585 84589972 An01g06160 Aspergillus niger uncharacterized protein XP_059599686.1 1455810 R 5061 CDS An01g06170 4977998 1460678..1461880 II 1 NT_166518.1 Title: strong similarity to EST an_1229 -Aspergillus niger; uncharacterized protein 1461880 4977998 An01g06170 Aspergillus niger uncharacterized protein XP_059599687.1 1460678 D 5061 CDS An01g06180 4977404 complement(join(1462326..1462591,1462659..1463056,1463139..1463201,1463332..1463480,1463592..1463666)) II 1 NT_166518.1 Catalytic activity: cytochrome c1 accepts electrons from the Rieske Fe-S protein and tranfers them to cytochrome c.; Catalytic activity: the complete cytochrome b-c1 enzyme complex catalyzes electron transfer from ubiquinol to the soluble cytochrome c; the transfer is coupled to translocation of two protons across the inner mithochondrial membrane per quinol oxidized.; Complex: the main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske Fe-S protein; in all organisms studied, the complex consists of 9-11 different polypeptides, and has an Mr of 240 kD.; Function: CYT1 of N. crassa is one heme-containing component of the cytochrome b-c1 complex, also called ubiquinol-cytochrome c oxidoreductase; it is a constituent of the mitochondrial respiratory chain.; Localization: cytochrome c1 is anchored to the inner mitochondrial membrane with its N-terminus protruding into the mitochondrial intermembrane space.; Remark: cytochrome b-c1 complex is highly conserved among living organisms; the crystal structure of the complete complex of mammals and chicken was determined.; Remark: the cytochrome c1 is synthesized as precursor, containing a N-terminal presequence removed by a peptidase.; Similarity: the predicted ORF is 14 amio acids shorter at the C-terminus than the N. crassa protein.; Title: strong similarity to cytochrome c1 of ubiquinol--cytochrome c reductase CYT-1 - Neurospora crassa; localisation:mitochondrion; See PMID 9204897; See PMID 9565029; See PMID 11192733; See PMID 11245784; See PMID 3030747; uncharacterized protein 1463666 4977404 An01g06180 Aspergillus niger uncharacterized protein XP_001389042.1 1462326 R 5061 CDS An01g06190 4977334 complement(join(1464136..1464333,1464400..1464696,1464759..1465110,1465159..1465226,1465303..1465602,1465697..1465786)) II 1 NT_166518.1 Function: it is proposed that, in general, the AAA domains act as ATP-dependent protein clamps.; Function: the PCH2 gene of S. cerevisiae is required for the meiotic checkpoint that prevents chromosome segregation when recombination and chromosome synapsis are defective.; Localization: most of the PCH2 protein localizes to the nucleolus; nucleolar localization of PCH2 is regulated by different proteins involved in meiotic checkpoint control.; Remark: PCH2 of S. cerevisiae is also known as YBR186w.; Similarity: strong similarity to HPV16 E1 binding protein of H. sapiens, a protein with unknown molecular function, but interacting with human papillomavirus E1 ATP-dependent DNA helicase.; Similarity: the predicted ORF contains a conserved region of about 220 amino acids that contains an ATP-binding site, and is called AAA, for 'A'TPases 'A'ssociated with diverse cellular 'A'ctivities.; Title: strong similarity to pachytene checkpoint protein Pch2 - Saccharomyces cerevisiae; nucleus; See PMID 9223484; See PMID 10319812; See PMID 11029058; uncharacterized protein 1465786 4977334 An01g06190 Aspergillus niger uncharacterized protein XP_059599688.1 1464136 R 5061 CDS An01g06200 84589973 join(1465915..1465993,1466333..1466378,1466454..1466514) II 1 NT_166518.1 Title: questionable ORF; uncharacterized protein 1466514 84589973 An01g06200 Aspergillus niger uncharacterized protein XP_059599689.1 1465915 D 5061 CDS An01g06210 4978008 join(1467205..1467247,1467334..1469620,1469670..1469940) II 1 NT_166518.1 Function: Rcy1 of S. cerevisiae is required for the recycling of internalized material to the plasma membrane anfter endocytosis.; Phenotype: S. cerevisiae cells with a Rcy1 null mutation are defective in endocytosis at an early postinternalization step, and are defective in recycling.; Remark: Rcy1 of S. cerevisiae is also known as YJL204c.; Similarity: Rcy1 of S. cerevisiae contains, near its N-terminus, an F-box domain, a motif which links the target protein with a ubiquitin-conjugating enzyme; the F-box is just marginally conserved in the predicted ORF.; Similarity: the predicted ORF shows strong similarity with the SLS2 gene of Y. lipolytica, whose molecular function is unknown, but can be important in secretory pathways.; Title: strong similarity to F-box protein Rcy1 -Saccharomyces cerevisiae; See PMID 10394896; See PMID 10769031; uncharacterized protein 1469940 4978008 An01g06210 Aspergillus niger uncharacterized protein XP_001389045.3 1467205 D 5061 CDS An01g06220 84589974 join(<1470593..1470794,1470873..1471083,1471130..1471166) II 1 NT_166518.1 Function: while C. albicans rbt4 strains show no phenotypes on several laboratory media, they had significantly reduced virulence.; Regulation: expression of C. albicans Rbt4 is induced in wild-type cells during the switch from the yeast form to filamentous growth, under control of TUP1.; Remark: ORF 5'truncated due to end of contig.; Title: strong similarity to secreted RBT4 - Candida albicans [truncated ORF]; extracellular/secretion proteins; uncharacterized protein 1471166 84589974 An01g06220 Aspergillus niger uncharacterized protein XP_059599690.1 1470593 D 5061 CDS An01g06230 4977446 complement(join(1471522..1471950,1472012..1473539,1473610..1473802,1473898..1473970)) II 1 NT_166518.1 Complex: eIF3 consists of at least 10 subunits: p170, p116 (eIF3 beta), p110, p66, p48, p47, p44, p40, p36, and p35.; Function: eIF3 stimulates the binding of Met-tRNAf (as a Met-tRNAf. eIF2. GTP ternary complex) to 40 S ribosomal subunits.; Title: strong similarity to translation initiation factor 3 subunit eIF3 beta - Homo sapiens; cytoplasm; See PMID 8995410; See PMID 9388245; uncharacterized protein 1473970 4977446 An01g06230 Aspergillus niger uncharacterized protein XP_001389047.1 1471522 R 5061 CDS An01g06240 4978328 join(1474738..1474744,1474845..1474972,1475078..1475551,1475604..1475657,1475716..1475901) II 1 NT_166518.1 Function: SWI/SNF is a chromatin-remodeling complex.; Function: yeast SWI/SNF complex is required for transcriptional activation by the glucocorticoid receptor.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger EST an_3193.; Similarity: similarity is from the topoisomerase I associated Zn-finger domain containing C-terminal region of the predicted A. niger protein to the central region of M. musculus BAF60a, which is 200 aa longer.; Similarity: the predicted A. niger protein contains a topoisomerase I associated Zn-finger domain.; Title: similarity to SWI/SNF complex subunit BAF60a - Mus musculus; nucleus; See PMID 11420722; See PMID 8804307; uncharacterized protein 1475901 4978328 An01g06240 Aspergillus niger uncharacterized protein XP_059599691.1 1474738 D 5061 CDS An01g06250 4977772 join(1476726..1477196,1477268..1477506,1477571..1479218) II 1 NT_166518.1 Similarity: the N-terminal region of the predicted A. niger protein contains a fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain. -; Title: strong similarity to hypothetical zinc-finger protein SPCC1223.01 - Schizosaccharomyces pombe; uncharacterized protein 1479218 4977772 An01g06250 Aspergillus niger uncharacterized protein XP_001389049.1 1476726 D 5061 CDS An01g06260 4978053 complement(join(1479561..1481107,1481154..1481241,1481292..1481411,1481452..1481607,1481652..1481692,1481747..1482065,1482109..1482398,1482463..1482541,1482628..1482654)) II 1 NT_166518.1 Complex: human MSH4 interacts specifically with MSH5 to form a heterodimer and MLH1.; Function: human MSH4 is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I.; Similarity: human MSH4 belongs to the eucaryotic E. coli MutHLS homologes, where MutS homologs in eucaryotes have evolved to play crucial roles in DNA mismatch repair and/or meiotic recombination.; Title: strong similarity to meiotic recombination protein MSH4 - Homo sapiens; nucleus; See PMID 10928988; See PMID 9299235; See PMID 10029069; uncharacterized protein 1482654 4978053 An01g06260 Aspergillus niger uncharacterized protein XP_059599692.1 1479561 R 5061 CDS An01g06270 4978501 join(1482792..1483016,1483083..1484167,1484222..1484465) II 1 NT_166518.1 Complex: D. melanogaster Nle binds to the cytoplasmic domain of Notch.; Function: X. laevis nle is a modulator of Notch signaling, with mutatios in D. melanogaster nle but also overexpression of D. melanogaster or X. laevis Nle enhancing Notch activity.; Title: strong similarity to modulator of Notch activity notchless nle - Xenopus laevis; See PMID 9857191; uncharacterized protein 1484465 4978501 An01g06270 Aspergillus niger uncharacterized protein XP_001389051.1 1482792 D 5061 CDS An01g06280 4978361 complement(join(1484813..1485136,1485244..1485504)) II 1 NT_166518.1 Remark: informations have only been published in Hemmann S. Thesis (1998), Institute of Biochemistry,University of Zurich Switzerland.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with PATENTDNA:AAF11390 A. niger EST 3913.; Title: strong similarity to IgE-binding protein -Aspergillus fumigatus; See PMID 9723708; uncharacterized protein 1485504 4978361 An01g06280 Aspergillus niger uncharacterized protein XP_001389052.1 1484813 R 5061 CDS An01g06290 4978006 complement(join(1487001..1487277,1487337..1487845,1488035..1488055)) II 1 NT_166518.1 Title: strong similarity to hypothetical protein related to VeA - Neurospora crassa; uncharacterized protein 1488055 4978006 An01g06290 Aspergillus niger uncharacterized protein XP_059599693.1 1487001 R 5061 CDS An01g06300 84589975 join(1491567..1491704,1491880..1492122) II 1 NT_166518.1 hypothetical protein 1492122 84589975 An01g06300 Aspergillus niger hypothetical protein XP_059599550.1 1491567 D 5061 CDS An01g06310 4977220 join(1492268..1492400,1492484..1494420) II 1 NT_166518.1 Catalytic activity: A. oryzae gtaA catalysed the hydrolysis not only of L-glutamine but also of D-glutamine.; Title: strong similarity to glutaminase A gtaA -Aspergillus oryzae; See PMID 10952006; uncharacterized protein 1494420 4977220 An01g06310 Aspergillus niger uncharacterized protein XP_001389055.1 1492268 D 5061 CDS An01g06320 84589976 join(1496713..1496751,1496838..1496928,1497009..1497055,1497106..1497247,1497404..1497520,1497561..1497677,1497886..1497958,1498049..1498177,1498266..1498334,1498538..1498580,1498913..1499050,1499141..1499437) II 1 NT_166518.1 Title: weak similarity to hypothetical protein SCP1.259 - Streptomyces coelicolor; uncharacterized protein 1499437 84589976 An01g06320 Aspergillus niger uncharacterized protein XP_059599551.1 1496713 D 5061 CDS An01g06330 4977111 join(1500577..1501337,1501508..1501871) II 1 NT_166518.1 Function: S. cerevisiae UPC2 is a heme-inhibited activator involved in sterol uptake and regulation of cell wall mannoproteins.; Remark: alternative names for S. cerevisiae UPC2 are MOX4 and YDR213w.; Remark: the 3'UTR of the predicted A. niger protein is covered by the A. niger EST an_1035.; Remark: the predicted A. niger protein contains a fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain.; Similarity: S. cerevisiae UPC2 is a zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type.; Similarity: similarity is between the predicted A. niger protein and the C-terminal region of S. cerevisiae UPC2, which is 600 aa longer.; Title: similarity to RNA polymerase II transcription factor Upc2 - Saccharomyces cerevisiae; nucleus; See PMID 11208779; See PMID 11292809; uncharacterized protein 1501871 4977111 An01g06330 Aspergillus niger uncharacterized protein XP_059603179.1 1500577 D 5061 CDS An01g06332 84589977 1501955..1502164 II 1 NT_166518.1 hypothetical protein 1502164 84589977 An01g06332 Aspergillus niger hypothetical protein XP_059603180.1 1501955 D 5061 CDS An01g06340 4977613 complement(join(1503179..1503366,1503479..1503688,1503779..1503821)) II 1 NT_166518.1 Title: weak similarity to hypothetical protein G65A3.10 - Neurospora crassa; uncharacterized protein 1503821 4977613 An01g06340 Aspergillus niger uncharacterized protein XP_001389059.1 1503179 R 5061 CDS An01g06350 4978164 complement(1504998..1506299) II 1 NT_166518.1 Function: human GnT-IV is an essential enzyme in the production of tri- and tetra-antennary Asn-linked sugar chains.; Title: weak similarity to UDP-N-acetylglucosamine:alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase GnT-IV - Homo sapiens; See PMID 9565571; See PMID 10570912; uncharacterized protein 1506299 4978164 An01g06350 Aspergillus niger uncharacterized protein XP_001389060.1 1504998 R 5061 CDS An01g06360 4977462 join(1507770..1508086,1508191..1508301,1508369..1508725,1508785..1508932) II 1 NT_166518.1 Function: A. alternata Akt3-1 is involved in AK-toxin biosynthesis.; Function: P. putida FadB is essential for the beta-oxidation of certain n-phenylalkanoyl-CoA derivatives when they reach a critical size.; Similarity: the predicted A. niger protein contains an enoyl-CoA hydratase motif and shows similarity to several putative enoyl-CoA hydratases and Pseudomonas putida FadB.; Title: strong similarity to AK-toxin production protein Akt3-1 - Alternaria alternata; See PMID 10975654; See PMID 11251808; uncharacterized protein 1508932 4977462 An01g06360 Aspergillus niger uncharacterized protein XP_001389061.1 1507770 D 5061 CDS An01g06370 4977611 complement(join(1509144..1509320,1509402..1509971)) II 1 NT_166518.1 Similarity: the ORF shows strong similarity to EST EMBLEST:BE758779 an_3023 of Aspergillus niger.; Title: strong similarity to hypothetical protein YKR065c - Saccharomyces cerevisiae; uncharacterized protein 1509971 4977611 An01g06370 Aspergillus niger uncharacterized protein XP_001389062.1 1509144 R 5061 CDS An01g06380 4977544 complement(join(1510869..1511055,1511105..1511186,1511319..1511370,1511421..1511613,1511674..1511960)) II 1 NT_166518.1 Title: weak similarity to serotonin receptor -Didelphis marsupialis virginiana; uncharacterized protein 1511960 4977544 An01g06380 Aspergillus niger uncharacterized protein XP_059603181.1 1510869 R 5061 CDS An01g06390 4978323 join(1512856..1512917,1513106..1514538,1514596..1515551,1515601..1515687) II 1 NT_166518.1 Similarity: the N-terminal region of the predicted protein contains a fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain.; Similarity: the ORF shows strong similarity to the A. niger EST EMBLEST:BE760705 an_0337.; Title: strong similarity to hypothetical protein EAA65779.1 - Aspergillus nidulans; uncharacterized protein 1515687 4978323 An01g06390 Aspergillus niger uncharacterized protein XP_059603182.1 1512856 D 5061 CDS An01g06400 4977541 1516523..1517674 II 1 NT_166518.1 hypothetical protein 1517674 4977541 An01g06400 Aspergillus niger hypothetical protein XP_001389065.1 1516523 D 5061 CDS An01g06410 10098219 join(1518414..1518572,1518635..1518714,1518769..1518949,1519001..1519054,1519134..1519632,1519726..1519992,1520040..1520338) II 1 NT_166518.1 Remark: a putative sequencing error results in an premature STOP codon.; Remark: the deletion of YGR260w in a bna1 auxotrophic mutant for nicotinic acid prevents growth at low nicotinic acid concentration. This suggests that YGR260w is necessary for nicotinic acid import into the cell.; Remark: the systematic name for TNA1 of S. cerevisiae is YGR260w.; Similarity: the ORF shows similarity to some allantoate permeases.; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae [putative sequencing error]; putative sequencing error; See PMID 10869563; uncharacterized protein 1520338 10098219 An01g06410 Aspergillus niger uncharacterized protein XP_059603183.1 1518414 D 5061 CDS An01g06420 4977583 complement(1520506..1521096) II 1 NT_166518.1 Title: weak similarity to hypothetical protein CAE81933.1 - Neurospora crassa; uncharacterized protein 1521096 4977583 An01g06420 Aspergillus niger uncharacterized protein XP_001389067.1 1520506 R 5061 CDS An01g06430 4977416 complement(join(1521844..1522358,1522405..1522474)) II 1 NT_166518.1 Remark: putative prolin rich protein.; hypothetical protein 1522474 4977416 An01g06430 Aspergillus niger hypothetical protein XP_001389068.1 1521844 R 5061 CDS An01g06440 4978159 join(1525191..1525437,1525500..1526209) II 1 NT_166518.1 Similarity: this gene shows also strong similarity to EST SEQ ID NO:4296 from patent WO200056762-A2 -Aspergillus niger.; Title: similarity to hypothetical protein CAE28089.1/RPA2648 - Rhodopseudomonas palustris; uncharacterized protein 1526209 4978159 An01g06440 Aspergillus niger uncharacterized protein XP_001389069.3 1525191 D 5061 CDS An01g06450 84589978 join(1526648..1526945,1527051..1527167,1527279..1527364) II 1 NT_166518.1 hypothetical protein 1527364 84589978 An01g06450 Aspergillus niger hypothetical protein XP_059603184.1 1526648 D 5061 CDS An01g06460 4978492 join(1528033..1528475,1528533..1528920) II 1 NT_166518.1 hypothetical protein 1528920 4978492 An01g06460 Aspergillus niger hypothetical protein XP_001389071.1 1528033 D 5061 CDS An01g06470 4977308 complement(join(1530318..1531753,1531810..1532187,1532274..1532349)) II 1 NT_166518.1 Function: CB-CYP4 of C. briggsae belongs to the peptidyl-prolyl cis-trans isomerase (rotamase)/cyclophilin family, which facilitates the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.; Similarity: the ORF shows similarity to several peptidyl-prolyl cis-trans isomerases from different species.; Title: strong similarity to peptidyl-prolyl cis-trans isomerase CB-CYP4 - Caenorhabditis elegans; uncharacterized protein 1532349 4977308 An01g06470 Aspergillus niger uncharacterized protein XP_001389072.1 1530318 R 5061 CDS An01g06480 4978512 join(1532612..1532614,1532682..1532839,1532915..1534289,1534357..1534416) II 1 NT_166518.1 Complex: hetero-oligomeric complex of about 850 to 900 kda that forms two stacked rings, 12 to 16 nm in diameter.; Function: molecular chaperone; assist the folding of proteins upon atp hydrolysis. known to play a role, in vitro, in the folding of actin and tubulin. in yeast may play a role in mitotic spindle formation.; Remark: TCP1 beta supplies an essential function that partially overlaps with that of TCP1 alpha in acting as a molecular chaperone in tubulin and spindle biogenesis.; Similarity: belongs to the molecular chaperone t-complex-type proteins.; Title: strong similarity to TCP1 complex beta chain TCP1 Beta - Saccharomyces cerevisiae; See PMID 7908441; See PMID 7916460; uncharacterized protein 1534416 4978512 An01g06480 Aspergillus niger uncharacterized protein XP_001389073.1 1532612 D 5061 CDS An01g06490 84589979 join(1535132..1535199,1535308..1535355,1535442..1535589,1535705..1536097) II 1 NT_166518.1 hypothetical protein 1536097 84589979 An01g06490 Aspergillus niger hypothetical protein XP_059603185.1 1535132 D 5061 CDS An01g06500 4978460 join(1536285..1536385,1536472..1537144,1537200..1537796) II 1 NT_166518.1 Remark: Phenotypic analysis of dfg mutant strains genetically dissects filamentous growth into the cellular processes of signal transduction, bud site selection, cell morphogenesis and invasive growth. Epistasis tests between dfg mutant alleles and dominant activated alleles of the RAS2 and STE11 genes, RAS2Val19 and STE11-4, respectively,identify putative targets for the filamentation signaling pathway. Several of the genes described here have homologues in filamentous fungi, where they also regulate fungal development.; Remark: alternative name is YMR238w.; Title: strong similarity to filamentous growth protein Dfg5 - Saccharomyces cerevisiae; See PMID 9055077; uncharacterized protein 1537796 4978460 An01g06500 Aspergillus niger uncharacterized protein XP_059603186.1 1536285 D 5061 CDS An01g06510 84589980 complement(join(1537892..1538029,1538139..1538300,1538490..1538540)) II 1 NT_166518.1 Remark: the ORF is short in length (116 amino acids) and has an unusual exon/intron structure for A. niger.; Title: questionable ORF; uncharacterized protein 1538540 84589980 An01g06510 Aspergillus niger uncharacterized protein XP_059603187.1 1537892 R 5061 CDS An01g06520 4977837 join(1538935..1538941,1539006..1541641) II 1 NT_166518.1 Remark: xNopp180 is heavily phosphorylated and it contains multiple consensus sites for phosphorylation by casein kinase II and cdc2 kinase.; Similarity: belongs to the nucleolus-cytoplasm shuttle phosphoprotein.; Title: similarity to nucleolar phosphoprotein xNopp180 - Xenopus laevis; See PMID 7593294; uncharacterized protein 1541641 4977837 An01g06520 Aspergillus niger uncharacterized protein XP_059603188.1 1538935 D 5061 CDS An01g06530 4977777 complement(join(1541928..1543066,1543145..1543217)) II 1 NT_166518.1 Catalytic activity: L-Leucine + 2-Oxoglutarate = 4-Methyl-2-oxopentanoate + L-Glutamate.; Pathway: valine, leucine and isoleucine degradation; valine, leucine and isoleucine biosynthesis; pantothenate and CoA biosynthesis.; Remark: TOXF has a biosynthetic role in HC-toxin synthesis, perhaps to aminate a precursor of Aeo (2-amino-9, 10-epoxi-8-oxodecanoic acid).; Title: strong similarity to branched-chain amino acid aminotransferase TOXF - Cochliobolus carbonum; See PMID 10627051; uncharacterized protein 1543217 4977777 An01g06530 Aspergillus niger uncharacterized protein XP_001389078.1 1541928 R 5061 CDS An01g06540 84589981 join(1543901..1544011,1544096..1544128,1544378..1544512) II 1 NT_166518.1 Title: questionable ORF; uncharacterized protein 1544512 84589981 An01g06540 Aspergillus niger uncharacterized protein XP_059603189.1 1543901 D 5061 CDS An01g06550 4977315 join(1544924..1547910,1547958..1548414) II 1 NT_166518.1 Pathway: unfolded protein response pathway (UPR).; Remark: in S. cerevisiae the ER transmembrane receptor, Ire1p, transmits the signal to the nucleus culminating in the transcriptional activation of genes encoding an adaptive response. Yeast Ire1p requires both protein kinase and site-specific endoribonuclease (RNase) activities to signal the UPR.; Similarity: belongs to the serine/threonine protein kinases.; Title: strong similarity to protein kinase Ire1 -Saccharomyces cerevisiae; deleted EC_number 2.7.1.37; endoplasmatic reticulum; See PMID 11069889; See PMID 1625574; See PMID 8358794; uncharacterized protein 1548414 4977315 An01g06550 Aspergillus niger uncharacterized protein XP_001389080.1 1544924 D 5061 CDS An01g06560 4977386 join(1548820..1548874,1548943..1549773,1549828..1550336) II 1 NT_166518.1 Catalytic activity: N-(L-arginino)succinate = fumarate + L-arginine.; Pathway: urea cycle and metabolism of amino groups; alanine and aspartate metabolism; arginine and proline metabolism.; Remark: argininosuccinate lyase (ASL) catalyzes the reversible hydrolysis of argininosuccinate to arginine and fumarate, a reaction important for the detoxification of ammonia via the urea cycle and for arginine biosynthesis. ASL belongs to a superfamily of structurally related enzymes, all of which function as tetramers and catalyze similar reactions in which fumarate is one of the products.; Similarity: to other argininosuccinate lyases.; Title: strong similarity to argininosuccinate lyase ASAL - Candida albicans; See PMID 11092456; See PMID 8194754; uncharacterized protein 1550336 4977386 An01g06560 Aspergillus niger uncharacterized protein XP_001389081.1 1548820 D 5061 CDS An01g06570 4977918 complement(join(1550663..1550795,1550930..1551884,1551938..1552100)) II 1 NT_166518.1 Title: similarity to hypothetical protein C29F5.1 -Caenorhabditis elegans; uncharacterized protein 1552100 4977918 An01g06570 Aspergillus niger uncharacterized protein XP_001389082.3 1550663 R 5061 CDS An01g06580 84589982 join(1552253..1552307,1552390..1552483,1552572..1552619,1552872..1552950) II 1 NT_166518.1 Remark: the ORF is short in length (91 amino acids) and has an unusual exon/intron structure for A. niger.; Title: questionable ORF; uncharacterized protein 1552950 84589982 An01g06580 Aspergillus niger uncharacterized protein XP_059603190.1 1552253 D 5061 CDS An01g06600 84589983 complement(join(1553463..1553536,1553672..1553753)) II 1 NT_166518.1 Remark: the ORF is short in length (51 amino acids) and has an unusual exon/intron structure for A. niger.; Title: questionable ORF; uncharacterized protein 1553753 84589983 An01g06600 Aspergillus niger uncharacterized protein XP_059603191.1 1553463 R 5061 CDS An01g06610 4977704 join(1554158..1554527,1554582..1556332) II 1 NT_166518.1 Title: strong similarity to hypothetical calcium-related spray protein 1A9.60 - Neurospora crassa; uncharacterized protein 1556332 4977704 An01g06610 Aspergillus niger uncharacterized protein XP_001389085.1 1554158 D 5061 CDS An01g06620 4977721 join(1556993..1558093,1558140..1559009) II 1 NT_166518.1 Catalytic activity: hydrolysis of terminal,non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.; Remark: RhaA and RhaB, optimally active at pH 4. 5 to 5, showed K(m) and V(max) values of 2. 8 mM and 24 U/mg (RhaA) and 0. 30 mM and 14 U/mg (RhaB) when tested for p-nitrophenyl-alpha-L-rhamnopyranoside.; Title: strong similarity to alpha-L-rhamnosidase A precursor rhaA - Aspergillus aculeatus; See PMID 11319105; uncharacterized protein 1559009 4977721 An01g06620 Aspergillus niger uncharacterized protein XP_001389086.1 1556993 D 5061 CDS An01g06630 4978185 join(1559119..1560378,1560443..1561831) II 1 NT_166518.1 Catalytic activity: hydrolysis of terminal,non-reducing beta-D-mannose residues in beta-D-mannosides.; Pathway: glycoprotein degradation.; Remark: Man2A is an intracellular enzyme comprising a catalytic module in a subfamily of family 2 of the glycosyl hydrolases that at present contains only mammalian beta-mannosidases.; Similarity: belongs to the beta-galactosidase/beta-glucuronidase family.; Title: strong similarity to mannosidase Man2A -Cellulomonas fimi; See PMID 10347049; uncharacterized protein 1561831 4978185 An01g06630 Aspergillus niger uncharacterized protein XP_001389087.1 1559119 D 5061 CDS An01g06640 4977898 complement(join(1561986..1563669,1563722..1563879)) II 1 NT_166518.1 Catalytic activity: phenol sulfate + h(2)o = phenol + sulfate.; Function: the P. aeruginosa homolog ATSA catalyzes the hydrolysis of Sulfate esters.; Repression: synthesis of P. aeruginosa ATSA is repressed when sulfate, cysteine or thiocyanate is supplied as the sole sulfur source for growth.; Title: strong similarity to arylsulfatase atsA -Pseudomonas aeruginosa; uncharacterized protein 1563879 4977898 An01g06640 Aspergillus niger uncharacterized protein XP_001389088.3 1561986 R 5061 CDS An01g06650 4978334 complement(join(1564515..1565337,1565404..1565765)) II 1 NT_166518.1 Title: strong similarity to hypothetical protein PA4204 - Pseudomonas aeruginosa; uncharacterized protein 1565765 4978334 An01g06650 Aspergillus niger uncharacterized protein XP_059603192.1 1564515 R 5061 CDS An01g06660 4977393 1566379..1567431 II 1 NT_166518.1 Catalytic activity: NADH + 2 ferricytochrome b5 <=> NAD(+) + 2 ferrocytochrome b5.; Function: the structure of H. sapiens AAF04812. 1 makes it a potential oxygen sensor.; Remark: the H. sapiens homolog AAF04812. 1 represents a natural fusion of cytochrome b5 (b5) and cytochrome b5 reductase (b5R).; Title: similarity to flavohemoprotein b5/b5R AAF04812.1 - Homo sapiens; cytoplasm; uncharacterized protein 1567431 4977393 An01g06660 Aspergillus niger uncharacterized protein XP_059603193.1 1566379 D 5061 CDS An01g06670 4977058 complement(join(1567581..1567749,1567841..1568079)) II 1 NT_166518.1 Similarity: the ORF overlaps with A. niger EST an_2741.; Similarity: the ORF shows similarity to cyclophilins and other FK506/rapamycin-binding proteins.; Similarity: the predicted ORF is 81 amino acids shorter at the C-terminus than FKBP-21 of N. crassa.; Title: strong similarity to peptidyl-prolyl isomerase FKBP-21 - Neurospora crassa; uncharacterized protein 1568079 4977058 An01g06670 Aspergillus niger uncharacterized protein XP_001389091.1 1567581 R 5061 CDS An01g06690 4977374 complement(1568770..1569825) II 1 NT_166518.1 Function: the S. cerevisiae homolog ZRT2 encodes a low-affinity zinc transporter.; Induction: S. cerevisiae ZRT1 is expressed in response to zinc deficiency.; Similarity: S. cerevisiae Zrt2p belongs to the family of ZIP metal ion transporters.; Title: strong similarity to low affinity zinc transport protein Zrt2 - Saccharomyces cerevisiae; plasma membrane; uncharacterized protein 1569825 4977374 An01g06690 Aspergillus niger uncharacterized protein XP_001389092.1 1568770 R 5061 CDS An01g06700 84589984 complement(join(1570844..1571117,1571154..1571173)) II 1 NT_166518.1 hypothetical protein 1571173 84589984 An01g06700 Aspergillus niger hypothetical protein XP_059603194.1 1570844 R 5061 CDS An01g06710 4977209 join(1571796..1574552,1574609..1574752) II 1 NT_166518.1 Title: similarity to hypothetical phosphorylase AAM06921.1 - Methanosarcina acetivorans; uncharacterized protein 1574752 4977209 An01g06710 Aspergillus niger uncharacterized protein XP_001389094.1 1571796 D 5061 CDS An01g06720 84589985 complement(join(1574889..1575201,1575253..1575315,1575418..1575448,1575486..1575534)) II 1 NT_166518.1 hypothetical protein 1575534 84589985 An01g06720 Aspergillus niger hypothetical protein XP_059603195.1 1574889 R 5061 CDS An01g06730 84589986 join(1575826..1576069,1576122..1576270,1576410..1576936,1577040..1577100) II 1 NT_166518.1 hypothetical protein 1577100 84589986 An01g06730 Aspergillus niger hypothetical protein XP_059603196.1 1575826 D 5061 CDS An01g06740 84589987 1577821..1578276 II 1 NT_166518.1 hypothetical protein 1578276 84589987 An01g06740 Aspergillus niger hypothetical protein XP_059603197.1 1577821 D 5061 CDS An01g06750 4978197 1578418..1579113 II 1 NT_166518.1 Similarity: the S. coelicolor homolog SCD72A. 11 has weakly similar to many acetyltransferases.; Title: similarity to hypothetical acetyltransferase SCD72A.11 - Streptomyces coelicolor; uncharacterized protein 1579113 4978197 An01g06750 Aspergillus niger uncharacterized protein XP_001389098.1 1578418 D 5061 CDS An01g06760 84589988 complement(join(1579537..1579574,1579623..1580527,1580599..1580759)) II 1 NT_166518.1 Title: weak similarity to hypothetical protein encoded by An08g03810 - Aspergillus niger; uncharacterized protein 1580759 84589988 An01g06760 Aspergillus niger uncharacterized protein XP_059603198.1 1579537 R 5061 CDS An01g06770 4978448 complement(join(1581391..1581496,1581732..1582261)) II 1 NT_166518.1 Title: similarity to hypothetical protein encoded by DR0613 - Deinococcus radiodurans; uncharacterized protein 1582261 4978448 An01g06770 Aspergillus niger uncharacterized protein XP_001389100.3 1581391 R 5061 CDS An01g06780 4977337 join(1582997..1583590,1583658..1584020,1584071..1584148) II 1 NT_166518.1 Title: similarity to actVA-ORF4-like protein A-ORFP from patent WO9911793-A1 - Homo sapiens; uncharacterized protein 1584148 4977337 An01g06780 Aspergillus niger uncharacterized protein XP_059603199.1 1582997 D 5061 CDS An01g06790 4978454 complement(join(1584701..1585030,1585081..1586791,1586849..1587451,1587513..1587537,1587593..1587790,1587846..1587959,1588016..1588153,1588213..1588426,1588484..1589025,1589266..1589312,1589524..1589553,1589726..1590092,1590200..1590520,1590590..1591367)) II 1 NT_166518.1 Function: M. musculus Ank3 is an epithelial ankyrin that is involved in the polarized distribution of many integral membrane proteins. ankyrins act as protein linker between the integral membrane proteins and the spectrin-based cytoskeleton.; Remark: ankyrin repeats are often contained in other proteins (which are not classified with the ankyrin family) and ensure protein-protein interactions as well as interactions between proteins and nucleic acids.; Remark: the M. musculus homolog Ank3 is significantly shorter.; Title: similarity to ankyrin 3 (splice form 4) - Mus musculus; cytoskeleton; uncharacterized protein 1591367 4978454 An01g06790 Aspergillus niger uncharacterized protein XP_059603200.1 1584701 R 5061 CDS An01g06800 4978124 join(1592071..1592079,1592140..1592245,1592380..1592493,1592576..1592812,1592875..1593159,1593218..1593335,1593404..1593587) II 1 NT_166518.1 Catalytic activity: N-acylsphingosine + H(2)O <=> a fatty acid + sphingosine.; Function: the S. cerevisiae homolog YPC1 encodes an alkaline ceramidase activity responsible for the breakdown of dihydroceramide and phytoceramide but not unsaturated ceramide. Ypc1p also has reverse activity, catalyzing synthesis of phytoceramide from palmitic acid and phytosphingosine.; Title: strong similarity to alkaline ceramidase Ypc1 - Saccharomyces cerevisiae; uncharacterized protein 1593587 4978124 An01g06800 Aspergillus niger uncharacterized protein XP_059603201.1 1592071 D 5061 CDS An01g06810 4977959 join(1594021..1594279,1594348..1595315) II 1 NT_166518.1 Title: strong similarity to transmembrane protein from patent WO9927105-A2 - Chlamydia pneumoniae; uncharacterized protein 1595315 4977959 An01g06810 Aspergillus niger uncharacterized protein XP_001389104.1 1594021 D 5061 CDS An01g06820 4978250 complement(join(1595677..1597112,1597168..1597666,1597726..1598864,1598927..1599007,1599064..1599103)) II 1 NT_166518.1 Function: the F. oxysporum homolog CYP505 encodes a membrane-bound fatty acid (omega-1-omega-3) hydroxylase. the physiological roles of the terminal hydroxylation of fatty acids are essentially unknown.; Localization: native F. oxysporum P450foxy was exclusively recovered in the membrane fraction of the fungal cells.; Remark: N- and C-terminal homologies respectively suggest that F. oxysporum P450foxy is a fused protein of P450 and its reductase.; Similarity: F. oxysporum P450foxy is the eukaryotic counterpart of bacterial P450BM3, but it is a unique cytochrome P450 in that it is self-sufficient, which means that it can complete its function without the aid of other proteinaceous components such as NADPH-cytochrome P450 oxidoreductase (referred to as P450reductase).; Title: strong similarity to fatty acid omega-hydroxylase (P450foxy) CYP505 - Fusarium oxysporum; uncharacterized protein 1599103 4978250 An01g06820 Aspergillus niger uncharacterized protein XP_001389105.1 1595677 R 5061 CDS An01g06830 4977557 join(1599653..1599673,1599733..1599799,1599859..1599926,1600058..1600771) II 1 NT_166518.1 Function: the S. cerevisiae TSC10 gene was found to encode 3-ketosphinganine reductase, the enzyme that catalyzes the second step in the synthesis of phytosphingosine, the long chain base found in yeast sphingolipids.; Remark: an alternative gene name for the S. cerevisiae homolog TSC10 is YBR265w.; Title: similarity to 3-ketosphinganine reductase Tsc10 - Saccharomyces cerevisiae; uncharacterized protein 1600771 4977557 An01g06830 Aspergillus niger uncharacterized protein XP_059603202.1 1599653 D 5061 CDS An01g06840 4977572 complement(join(1601160..1601254,1601338..1602748)) II 1 NT_166518.1 Function: the S. cerevisiae homolog FAT2 encodes a putative acyl-CoA synthetase that may be involved in peroxisomal fatty acid metabolism.; Induction: expression of S. cerevisiae Fat2p is highly inducible by oleic acid.; Remark: alternative gene names for S. cerevisiae FAT2 are PCS60 and YBR222C.; Similarity: high similarity to the Escherichia coli long chain acyl-CoA synthetase.; Title: strong similarity to acid-CoA ligase Fat2 -Saccharomyces cerevisiae; peroxisome; uncharacterized protein 1602748 4977572 An01g06840 Aspergillus niger uncharacterized protein XP_059603203.1 1601160 R 5061 CDS An01g06850 4978147 join(1603161..1603246,1603283..1603511,1603569..1604480) II 1 NT_166518.1 Catalytic activity: 4-hydroxybutanoate + NAD(+) <=> succinate semialdehyde + NADH; Pathway: butanoate metabolism.; Title: similarity to 4-hydroxybutyrate dehydrogenase - Alcaligenes eutrophus; uncharacterized protein 1604480 4978147 An01g06850 Aspergillus niger uncharacterized protein XP_059603204.1 1603161 D 5061 CDS An01g06860 4977396 1604827..1605723 II 1 NT_166518.1 Title: strong similarity to hypothetical protein Fum9p - Gibberella moniliformis; uncharacterized protein 1605723 4977396 An01g06860 Aspergillus niger uncharacterized protein XP_001389109.1 1604827 D 5061 CDS An01g06870 4977751 join(1606338..1606379,1606608..1607176,1607249..1607715,1607774..1607864,1607909..1608339,1608393..1609249) II 1 NT_166518.1 Title: strong similarity to hypothetical protein Fum8p - Gibberella moniliformis; uncharacterized protein 1609249 4977751 An01g06870 Aspergillus niger uncharacterized protein XP_059603205.1 1606338 D 5061 CDS An01g06880 4977685 1609568..1610617 II 1 NT_166518.1 Title: similarity to dihydroflavonol 4-reductase BAA12723.1 - Rosa hybrid cultivar; See PMID 8528604; uncharacterized protein 1610617 4977685 An01g06880 Aspergillus niger uncharacterized protein XP_001389111.1 1609568 D 5061 CDS An01g06890 4977684 complement(join(1610959..1612169,1612272..1612517,1612590..1612662,1612729..1612739,1612804..1612885)) II 1 NT_166518.1 Similarity: the ORF is shorter than pesA of M. anisopliae (540 compared to 5157 amino acids).; Similarity: the ORF shows similarity to peptide and toxin synthetases of different species.; Title: similarity to peptide synthase pesA -Metarhizium anisopliae; See PMID 8964498; uncharacterized protein 1612885 4977684 An01g06890 Aspergillus niger uncharacterized protein XP_059603206.1 1610959 R 5061 CDS An01g06900 84589989 complement(join(1613643..1613755,1613822..1613853,1613910..1614370,1614427..1614633,1614760..1615006,1615059..1615080,1615148..1615385,1615512..1615970,1616025..1616056,1616127..1616250,1616405..1616420,1616530..1616592,1616705..1616808)) II 1 NT_166518.1 Title: weak similarity to transcription regulator of maltose utilization amyR - Aspergillus oryzae; See PMID 10830498; uncharacterized protein 1616808 84589989 An01g06900 Aspergillus niger uncharacterized protein XP_059603207.1 1613643 R 5061 CDS An01g06910 4977471 join(1617793..1618049,1618133..1619447,1619641..1619685,1619792..1619917,1619963..1620043) II 1 NT_166518.1 Function: in S. cerevisiae expressed CYP94A5 from Nicotiana tabacum is able to catalyze the oxidation of fatty acids to the omega-alcohol and to the corresponding diacid.; Title: strong similarity to cytochrome P450 CYP94A5 - Nicotiana tabacum; See PMID 11358528; uncharacterized protein 1620043 4977471 An01g06910 Aspergillus niger uncharacterized protein XP_001389114.3 1617793 D 5061 CDS An01g06920 4977824 join(1620350..1620559,1620621..1623583,1623653..1624099,1624184..1624279,1624338..1625031) II 1 NT_166518.1 Title: strong similarity to multidrug resistance protein ABCC2 - Homo sapiens; uncharacterized protein 1625031 4977824 An01g06920 Aspergillus niger uncharacterized protein XP_001389115.1 1620350 D 5061 CDS An01g06930 4977719 complement(join(1625470..1626871,1626951..1627282,1627351..1627713,1627780..1628656,1628717..1630020,1630121..1630992,1631060..1632932,1632996..1633051,1633094..1633457)) II 1 NT_166518.1 Title: strong similarity to polyketide synthase FUM5 - Gibberella moniliformis; See PMID 10413619; uncharacterized protein 1633457 4977719 An01g06930 Aspergillus niger uncharacterized protein XP_059603208.1 1625470 R 5061 CDS An01g06940 4977089 join(1634989..1635812,1635881..1636114,1636193..1636742) II 1 NT_166518.1 Title: strong similarity to hypothetical transmembrane transport protein SCC30.17c - Streptomyces coelicolor; uncharacterized protein 1636742 4977089 An01g06940 Aspergillus niger uncharacterized protein XP_001389117.3 1634989 D 5061 CDS An01g06950 4978320 complement(join(1637123..1637950,1638010..1638324,1638377..1638925,1639019..1641265,1641314..1642992,1643023..1643173,1643241..1643338,1643392..1643516,1643568..1643876,1643934..1644408,1644463..1644535)) II 1 NT_166518.1 Remark: the nearby located ORF An01g06930 is also homolog to polyketide synthase FUM5.; Title: strong similarity to polyketide synthase FUM5 - Gibberella moniliformis; See PMID 10413619; uncharacterized protein 1644535 4978320 An01g06950 Aspergillus niger uncharacterized protein XP_059603209.1 1637123 R 5061 CDS An01g06960 4977342 complement(1648485..1649579) II 1 NT_166518.1 Title: strong similarity to hypothetical phosphatidyl synthase SPAC22A12.08c - Schizosaccharomyces pombe; uncharacterized protein 1649579 4977342 An01g06960 Aspergillus niger uncharacterized protein XP_001389119.3 1648485 R 5061 CDS An01g06970 4977800 join(1651816..1652223,1652290..1652859) II 1 NT_166518.1 Catalytic activity: ARA1 of S. cerevisiae catalyzes the reaktion D-arabinose + NAD(P)(+) <=> D-arabinono-1,4-lactone + NAD(P)H.; Complex: ARA1 of S. cerevisiae is a heterodimer of a heavy chain and a light chain.; Function: ARA1 of S. cerevisiae catalyzes the oxidation of D-arabinose, L-xylose, L-fucose and L-galactose in the presence of NADP(+).; Remark: YBR149W and YBR1127 are alternative names for ARA1.; Similarity: ARA1 of S. cerevisiae belongs to the aldo/keto reductase family.; Similarity: shows similarity to several known and hypothetical oxidoreductases with different specificities.; Title: strong similarity to D-arabinose dehydrogenase Ara1 - Saccharomyces cerevisiae; See PMID 9920381; uncharacterized protein 1652859 4977800 An01g06970 Aspergillus niger uncharacterized protein XP_001389120.1 1651816 D 5061 CDS An01g06980 84589990 complement(join(1655089..1655138,1655276..1655396)) II 1 NT_166518.1 hypothetical protein 1655396 84589990 An01g06980 Aspergillus niger hypothetical protein XP_059603210.1 1655089 R 5061 CDS An01g06990 4977197 complement(join(1655788..1657430,1657492..1657868,1658060..1658106)) II 1 NT_166518.1 Remark: blastp matches are unspecific.; hypothetical protein 1658106 4977197 An01g06990 Aspergillus niger hypothetical protein XP_001389122.1 1655788 R 5061 CDS An01g07000 4977711 complement(join(1658528..1659630,1659709..1660016,1660079..1660119)) II 1 NT_166518.1 Function: ERG24 of S. cerevisiae reduces the c14=c15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24- dienol.; Pathway: ERG24 of S. cerevisiae is involved in ergosterol biosynthesis.; Repression: ERG24 of S. cerevisiae is inhibited by the morpholine antifungal drug fenpropimorph.; Similarity: ERG24 of S. cerevisiae belongs to the erg4/erg24 family; Title: strong similarity to C-14 sterol reductase Erg24 - Saccharomyces cerevisiae; See PMID 8125337; See PMID 1418625; uncharacterized protein 1660119 4977711 An01g07000 Aspergillus niger uncharacterized protein XP_001389123.1 1658528 R 5061 CDS An01g07010 4978064 join(1660378..1660401,1660457..1661323) II 1 NT_166518.1 Remark: the orf encoded protein also shows weak similarity to human ovarian tumor EST fragment encoded protein 82.; Similarity: only the N-terminal 100 aminoacids show similarity to the N-terminal 100 aminoacids SPBC18H10. 07 of S. pombe.; Title: similarity to hypothetical protein SPBC18H10.07 - Schizosaccharomyces pombe; uncharacterized protein 1661323 4978064 An01g07010 Aspergillus niger uncharacterized protein XP_001389124.1 1660378 D 5061 CDS An01g07020 84589991 1662722..1664455 II 1 NT_166518.1 Similarity: similarities to other are mainly based on repetetive structures.; Title: similarity to hypothetical zinc-finger protein - Schizosaccharomyces pombe; nucleus; uncharacterized protein 1664455 84589991 An01g07020 Aspergillus niger uncharacterized protein XP_059603211.1 1662722 D 5061 CDS An01g07025 4977625 join(1664655..1664871,1664922..1665784) II 1 NT_166518.1 hypothetical protein 1665784 4977625 An01g07025 Aspergillus niger hypothetical protein XP_001389126.1 1664655 D 5061 CDS An01g07030 4977968 complement(join(1666322..1666420,1666481..1666720,1666788..1667200,1667287..1667501,1667605..1667657)) II 1 NT_166518.1 Catalytic activity: yiaE of E. coli catalizes the reduction of 2, 5-diketo-D-gluconate to 5-keto-D-gluconate,2-keto-D-gluconate (2KDG) to D-gluconate,2-keto-L-gulonate to L-idonate with NADPH as a preferred electron donor.; Title: strong similarity to 2-ketoaldonate reductase yiaE - Escherichia coli; See PMID 9811658; uncharacterized protein 1667657 4977968 An01g07030 Aspergillus niger uncharacterized protein XP_001389127.1 1666322 R 5061 CDS An01g07040 4977819 complement(join(1668118..1668945,1668997..1670310)) II 1 NT_166518.1 Title: similarity to hypothetical protein SPAC30D11.09 - Schizosaccharomyces pombe; uncharacterized protein 1670310 4977819 An01g07040 Aspergillus niger uncharacterized protein XP_001389128.1 1668118 R 5061 CDS An01g07050 4977855 join(1670578..1670620,1670679..1671832) II 1 NT_166518.1 Function: the gro-1 gene, together with the gop-1,gop-2, gop-3 and hap-1 genes enables study of a physiological clock; Similarity: shows similarity to GOP-2 protein of C. elegans from patent Y02529.; Title: strong similarity to hypothetical protein SPBC119.15 - Schizosaccharomyces pombe; uncharacterized protein 1671832 4977855 An01g07050 Aspergillus niger uncharacterized protein XP_001389129.1 1670578 D 5061 CDS An01g07060 4977076 join(1672496..1672501,1672559..1672676,1672737..1673139,1673187..1673261,1673323..1673366,1673399..1673634,1673937..1673947,1674003..1674294) II 1 NT_166518.1 hypothetical protein 1674294 4977076 An01g07060 Aspergillus niger hypothetical protein XP_001389130.3 1672496 D 5061 CDS An01g07070 84589992 join(1675083..1675092,1675128..>1675823) II 1 NT_166518.1 Catalytic activity: GUK1 of B. taurus catalyzes the reaction ATP + GMP = ADP + GDP:; Function: GUK1 of B. taurus is essential for recycling GMP and indirectly, cGMP.; Remark: a putative frameshift results in an premature STOP codon.; Similarity: GUK1 of B. taurus shows similarity to other guanylate kinases:; Title: strong similarity to guanylate kinase GUK1 -Bos taurus [putative frameshift]; putative frameshift; See PMID 8243671; uncharacterized protein 1675823 84589992 An01g07070 Aspergillus niger uncharacterized protein XP_059603212.1 1675083 D 5061 CDS An01g07080 4977217 complement(join(1675867..1675939,1676053..1676149,1676472..1676840,1676967..1676976)) II 1 NT_166518.1 Remark: similarity of the ORF encoded protein to similar proteins is mainly based on repetitive amino acids.; hypothetical protein 1676976 4977217 An01g07080 Aspergillus niger hypothetical protein XP_059603213.1 1675867 R 5061 CDS An01g07090 4977349 join(1677351..1677413,1677483..1678286) II 1 NT_166518.1 Remark: the similarity of the ORF encoded protein to similar proteins in mainly based on repetitive amino acids.; hypothetical protein 1678286 4977349 An01g07090 Aspergillus niger hypothetical protein XP_059603214.1 1677351 D 5061 CDS An01g07100 4978162 complement(join(1678421..1678482,1678529..1678874,1678921..1679004,1679063..1679240,1679300..1679418)) II 1 NT_166518.1 Catalytic activity: Glutathione transferases catalize the reaction RX + glutathione = HX + R-S-glutathione, X may be a sulfate, nitrite or halide group, and R may be an aliphatic, aromatic or heterocyclic group.; Function: the glutathione transferase from patent Y05537 is involved in herbicide metabolism.; Title: strong similarity to subunit TaGST1 from patent WO9914337-A2 - Triticum aestivum; uncharacterized protein 1679418 4978162 An01g07100 Aspergillus niger uncharacterized protein XP_001389135.3 1678421 R 5061 CDS An01g07110 84589993 complement(join(1679471..1679629,1679673..1680234,1680289..1680683)) II 1 NT_166518.1 Title: weak similarity to hypothetical protein encoded by An14g00090 - Aspergillus niger; uncharacterized protein 1680683 84589993 An01g07110 Aspergillus niger uncharacterized protein XP_059603215.1 1679471 R 5061 CDS An01g07120 4978329 complement(join(1681360..1682267,1682328..1682514,1682573..1682934,1682993..1683103,1683166..1684557,1684614..1684908,1684979..1685677)) II 1 NT_166518.1 Catalytic activity: 5-oxo-L-prolinases catalize the reaktion of ATP + 5-oxo-L-proline + 2 H(2)O = ADP + phosphate + L-glutamate.; Function: 5-oxo-L-prolinases are involved in the cleavage of glutathion.; Title: strong similarity to ATP-hydrolyzing 5-oxoprolinase - Rattus norvegicus; See PMID 8943290; See PMID 9516961; uncharacterized protein 1685677 4978329 An01g07120 Aspergillus niger uncharacterized protein XP_059603216.1 1681360 R 5061 CDS An01g07130 4978284 join(1686178..1687026,1687113..1687550) II 1 NT_166518.1 Catalytic activity: salicylate + NADH + O2 = catechol + NAD+ + H2O + CO2.; EC:1.14.13.1; Remark: alternate name = salicylate hydroxylase.; Remark: the enzyme of Pseudomonas putida is an external flavoprotein monooxygenase, which uses NADH as the external reductant.; Title: strong similarity to salicylate 1-monooxygenase sal1 - Pseudomonas putida; See PMID 1917904; uncharacterized protein 1687550 4978284 An01g07130 Aspergillus niger uncharacterized protein XP_059603217.1 1686178 D 5061 CDS An01g07140 4978443 complement(join(1687708..1687781,1688021..1690292)) II 1 NT_166518.1 Function: the transcription factor regulates the nmt1 promoter in fission yeast; mnt1 is also repressed by thiamine.; Remark: strong similarity only over the N-terminal part of the protein.; Title: similarity to transcription factor ntf1p -Schizosaccharomyces pombe; nucleus; See PMID 8163491; uncharacterized protein 1690292 4978443 An01g07140 Aspergillus niger uncharacterized protein XP_059603218.1 1687708 R 5061 CDS An01g07150 4977109 join(1690813..1690962,1691030..1691113,1691170..1691641,1691717..1692165,1692228..1692587) II 1 NT_166518.1 Function: CYHR of C. maltosa confers resistance to cycloheximide.; Remark: CYHR of C. maltosa is a transmembrane protein and probably a transporter.; Title: strong similarity to cycloheximide resistance protein CYHR - Candida maltosa; plasma membrane; See PMID 1628836; uncharacterized protein 1692587 4977109 An01g07150 Aspergillus niger uncharacterized protein XP_001389139.1 1690813 D 5061 CDS An01g07160 4977499 complement(join(1694284..1695478,1695533..1695989,1696062..1696230)) II 1 NT_166518.1 Title: strong similarity to tubulin-folding cofactor E - Homo sapiens; uncharacterized protein 1696230 4977499 An01g07160 Aspergillus niger uncharacterized protein XP_001389140.1 1694284 R 5061 CDS An01g07170 4977299 join(1696478..1696489,1696550..1697254) II 1 NT_166518.1 Remark: component of U2 snRNP in H. sapiens.; Remark: protein in H. sapiens is about two fold longer than in fungi.; Remark: subunit of the mammalian splicing factor SF3a.; Title: strong similarity to spliceosome-associated protein SAP62 - Homo sapiens; nucleus; See PMID 9016565; uncharacterized protein 1697254 4977299 An01g07170 Aspergillus niger uncharacterized protein XP_001389141.1 1696478 D 5061 CDS An01g07180 4977873 complement(join(1697888..1698200,1698252..1698728,1698813..1699316,1699399..1700012)) II 1 NT_166518.1 Title: strong similarity to serine/threonine kinase cot-1 - Neurospora crassa; See PMID 9680960; uncharacterized protein 1700012 4977873 An01g07180 Aspergillus niger uncharacterized protein XP_001389142.1 1697888 R 5061 CDS An01g07190 4977886 1701228..1702571 II 1 NT_166518.1 Complex: Tim54 of S. cerevisiae forms together with Tim22 the TIM22. 54 complex in the mitochondrial inner membrane.; Function: Tim54 of S. cerevisiae is a component of a complex neccessary for insertion of imported proteins in the mitochondrial inner membrane.; Remark: the TIM23. 17 complex is required for translocation of proteins across the inner membrane,whereas TIM22. 54 is required for insertion of proteins in the mitochondrial inner membrane.; Title: strong similarity to component of the translocase of mitochondrial inner membrane Tim54 -Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9412462; See PMID 10637294; uncharacterized protein 1702571 4977886 An01g07190 Aspergillus niger uncharacterized protein XP_001389143.3 1701228 D 5061 CDS An01g07200 4977048 complement(join(1703313..1703776,1703827..1705782,1705863..1705944)) II 1 NT_166518.1 EC:2.4.1.-; Remark: located in cytosol and in nucleus in Rattus norvegicus.; Title: similarity to N-acetylglucosaminyltransferases chain p110 - Rattus norvegicus; cytoplasm; uncharacterized protein 1705944 4977048 An01g07200 Aspergillus niger uncharacterized protein XP_001389144.1 1703313 R 5061 CDS An01g07210 4978292 complement(join(1706131..1706287,1706644..1707175,1707258..1707330)) II 1 NT_166518.1 Remark: only partial similarities.; Title: similarity to caffeine-induced death protein cid2p - Schizosaccharomyces pombe; See PMID 10036242; See PMID 10757807; uncharacterized protein 1707330 4978292 An01g07210 Aspergillus niger uncharacterized protein XP_001389145.3 1706131 R 5061 CDS An01g07220 4977406 join(1707856..1708448,1708505..1709039) II 1 NT_166518.1 Function: MutM protein removes the oxidatively damaged DNA base product, 8-oxoguanine (GO) in Thermus thermophilus.; Title: similarity to formamidopyrimidine-DNA glycosidase MutM - Thermus thermophilus; See PMID 9461446; See PMID 10731660; uncharacterized protein 1709039 4977406 An01g07220 Aspergillus niger uncharacterized protein XP_001389146.1 1707856 D 5061 CDS An01g07230 4977490 complement(1709162..1710070) II 1 NT_166518.1 Title: similarity to hypothetical protein DRB0099 -Deinococcus radiodurans; uncharacterized protein 1710070 4977490 An01g07230 Aspergillus niger uncharacterized protein XP_001389147.1 1709162 R 5061 CDS An01g07240 4978195 join(1710599..1710706,1710780..1712465) II 1 NT_166518.1 Title: similarity to NADP-reducing hydrogenase D chain - Desulfovibrio fructosovorans; See PMID 7751270; uncharacterized protein 1712465 4978195 An01g07240 Aspergillus niger uncharacterized protein XP_001389148.1 1710599 D 5061 CDS An01g07250 4977472 join(1713068..1713267,1713397..1713421) II 1 NT_166518.1 Catalytic activity: nucleoside triphosphate + RNA(n) = pyrophosphate + RNA(n+1).; Function: catalyses DNA-template-directed extention of the 3'- end of an RNA strand by one nucleotide at a time.; Remark: ABC10 alpha of S. cerevisiae is also called RPB12 or RPC10.; Title: strong similarity to 7.7 kD subunit of DNA-directed RNA polymerase II Abc10-alpha - Saccharomyces cerevisiae; nucleus; See PMID 1617300; uncharacterized protein 1713421 4977472 An01g07250 Aspergillus niger uncharacterized protein XP_001389149.1 1713068 D 5061 CDS An01g07260 4977420 complement(join(1713888..1714847,1714916..1715242)) II 1 NT_166518.1 Catalytic activity: N-(5-phospho-D-ribosyl)anthranilate + pyrophosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.; Title: strong similarity to anthranilate phosphoribosyltransferase - Saccharomyces cerevisiae; See PMID 2428012; uncharacterized protein 1715242 4977420 An01g07260 Aspergillus niger uncharacterized protein XP_001389150.1 1713888 R 5061 CDS An01g07270 4977370 1715638..1716693 II 1 NT_166518.1 Remark: partial similarities over the C-terminus.; Title: similarity to mitochondrial ribosomal protein of the large subunit Yml11 - Saccharomyces cerevisiae; See PMID 9162110; mitochondrial 54S ribosomal protein uL10m 1716693 4977370 An01g07270 Aspergillus niger mitochondrial 54S ribosomal protein uL10m XP_001389151.1 1715638 D 5061 CDS An01g07280 4977624 complement(1717088..1718617) II 1 NT_166518.1 Catalytic activity: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate.; Function: the L. monocytogenes enzyme plays a role during infections of mammalian cells.; Remark: the database proteins are app. 130 aa shorter.; Title: similarity to precursor of phosphatidylinositol-specific phospholipase C - Listeria monocytogenes; See PMID 8331063; See PMID 9367761; See PMID 1662763; uncharacterized protein 1718617 4977624 An01g07280 Aspergillus niger uncharacterized protein XP_001389152.3 1717088 R 5061 CDS An01g07290 4977143 join(1720285..1722467,1722515..1723243,1723629..1723655,1723688..1723964) II 1 NT_166518.1 Remark: the ORF has an unusual exon/intron structure for A. niger.; hypothetical protein 1723964 4977143 An01g07290 Aspergillus niger hypothetical protein XP_059603219.1 1720285 D 5061 CDS An01g07300 4977713 complement(join(1724256..1724708,1724809..1724976)) II 1 NT_166518.1 Catalytic activity: ATP + D-gluconate = ADP + 6-phospho-D-gluconate.; Remark: alternate name = gluconate kinase 2 in Escherichia coli.; Title: strong similarity to gluconokinase gntV -Escherichia coli; See PMID 8655507; See PMID 9151423; uncharacterized protein 1724976 4977713 An01g07300 Aspergillus niger uncharacterized protein XP_001389154.3 1724256 R 5061 CDS An01g07310 84589994 join(1726170..1726246,1726512..1726679,1726864..1726888,1726969..1727265,1727659..1727781) II 1 NT_166518.1 Remark: questionable gene structure.; hypothetical protein 1727781 84589994 An01g07310 Aspergillus niger hypothetical protein XP_059603220.1 1726170 D 5061 CDS An01g07320 4977884 join(1727826..1728045,1728157..1728629,1728692..1728716,1728815..1728931,1729365..1729588) II 1 NT_166518.1 Function: protein performs a role in the delivery of proteins to the vacuole.; Remark: the embryogenesis protein H beta 58 protein of the mouse is also named vacuolar sorting protein (see AC: AB015476).; Title: strong similarity to embryogenesis protein H beta 58 - Mus musculus; uncharacterized protein 1729588 4977884 An01g07320 Aspergillus niger uncharacterized protein XP_001389156.1 1727826 D 5061 CDS An01g07330 4977353 complement(join(1729975..1730055,1730134..1732194,1732312..1733744,1733868..1734116,1734198..1734708,1734763..1734869,1734912..1735118,1735166..1735339,1735402..1735468,1735527..1735604)) II 1 NT_166518.1 Function: the guanine nucleotide-exchange proteins (GEPs) accelerate replacement of bound GDP with GTP.; Remark: only partial similarity over the N-Terminus.; Title: similarity to brefeldin A-inhibited guanine nucleotide-exchange protein 2 - Homo sapiens; See PMID 10212200; uncharacterized protein 1735604 4977353 An01g07330 Aspergillus niger uncharacterized protein XP_059603221.1 1729975 R 5061 CDS An01g07340 84589995 join(1735630..1735704,1735810..1735856,1735948..1736083) II 1 NT_166518.1 hypothetical protein 1736083 84589995 An01g07340 Aspergillus niger hypothetical protein XP_059603222.1 1735630 D 5061 CDS An01g07350 4977407 join(1736104..1736176,1736246..1736325,1736398..1736523,1736586..1736665,1736720..1736780) II 1 NT_166518.1 Function: Mms2 and Ubc13 form a complex required for a novel polyubiquitin chain assembly in yeast.; Function: part of the error-free postreplication repair pathway.; Title: strong similarity to ubiquitin conjugating enzyme like protein Mms2 - Saccharomyces cerevisiae; nucleus; See PMID 9576943; See PMID 9705497; See PMID 10924462; uncharacterized protein 1736780 4977407 An01g07350 Aspergillus niger uncharacterized protein XP_001389159.3 1736104 D 5061 CDS An01g07360 4977108 join(1737408..1737456,1737547..1737689,1737757..1738444,1738522..1738572,1738656..1738730,1738818..1739032) II 1 NT_166518.1 Title: weak similarity to hypothetical protein B7F18.80 - Neurospora crassa; uncharacterized protein 1739032 4977108 An01g07360 Aspergillus niger uncharacterized protein XP_059603223.1 1737408 D 5061 CDS An01g07370 4977252 complement(join(1739060..1739697,1739773..1739839)) II 1 NT_166518.1 Title: strong similarity to PTD013 - Homo sapiens; uncharacterized protein 1739839 4977252 An01g07370 Aspergillus niger uncharacterized protein XP_001389161.1 1739060 R 5061 CDS An01g07380 4978255 join(1740285..1740841,1740906..1741509,1741722..1741823) II 1 NT_166518.1 Remark: the S. pombe protein possibly interacts with protein phosphatase two C.; Title: strong similarity to hypothetical protein SPBC16D10.01c - Schizosaccharomyces pombe; uncharacterized protein 1741823 4978255 An01g07380 Aspergillus niger uncharacterized protein XP_001389162.3 1740285 D 5061 CDS An01g07390 4977953 join(1741875..1742127,1742188..1742498,1742560..1743099,1743164..1743343,1743402..1743543,1743662..1743723) II 1 NT_166518.1 Remark: sir proteins from Kluyveromyces lactis are essential for transcriptional silencing of mating type loci.; Title: similarity to regulator protein SIR2 -Kluyveromyces marxianus; nucleus; See PMID 8007956; See PMID 9539421; uncharacterized protein 1743723 4977953 An01g07390 Aspergillus niger uncharacterized protein XP_001389163.3 1741875 D 5061 CDS An01g07400 4978489 join(1744151..1744264,1744449..1745323,1745390..1745561,1745662..1745769) II 1 NT_166518.1 Remark: last exon seems to be in the wrong frame,maybe due to the contig end.; Title: strong similarity to hypothetical protein YOL124c - Saccharomyces cerevisiae; uncharacterized protein 1745769 4978489 An01g07400 Aspergillus niger uncharacterized protein XP_059603224.1 1744151 D 5061 CDS An01g07410 4977193 complement(join(<1746128..1746343,1746566..1746677,1746860..1747204,1747427..1747527,1747618..>1747633)) II 1 NT_166518.1 Remark: only partial similarities.; Title: weak similarity to histidine triad protein Hnt1 - Saccharomyces cerevisiae; See PMID 10958787; See PMID 11805111; uncharacterized protein 1747633 4977193 An01g07410 Aspergillus niger uncharacterized protein XP_001389165.3 1746128 R 5061 CDS An01g07420 4977464 complement(join(1748258..1748355,1748411..1748549,1748602..1749807)) II 1 NT_166518.1 Complex: cyclin B (nimE) of E. nidulans interacts with nimTcdc25 tyrosine phosphatase.; Function: cyclin B (nimE) of E. nidulans is a subunit of the mitotic progression factor (MPF).; Similarity: the predicted A. niger protein shows strong similarity to cyclin B (nimE) of E. nidulans.; Title: strong similarity to cyclin B nimE -Aspergillus nidulans; See PMID 9552417; See PMID 1534750; uncharacterized protein 1749807 4977464 An01g07420 Aspergillus niger uncharacterized protein XP_001389166.3 1748258 R 5061 CDS An01g07430 4977910 join(1751522..1752281,1752384..1752868) II 1 NT_166518.1 Function: ribosomal yeast protein l2 is a 37-kDa polypeptide component of the mitochondria 54 S large ribosomal subunit.; Title: strong similarity to mitochondrial ribosomal protein of the large subunit L2 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9079633; mitochondrial 54S ribosomal protein uL2m 1752868 4977910 An01g07430 Aspergillus niger mitochondrial 54S ribosomal protein uL2m XP_059605893.1 1751522 D 5061 CDS An01g07440 84589996 complement(join(1753329..1753565,1753664..1753699)) II 1 NT_166518.1 hypothetical protein 1753699 84589996 An01g07440 Aspergillus niger hypothetical protein XP_059605894.1 1753329 R 5061 CDS An01g07445 84589997 1753743..1754087 II 1 NT_166518.1 Remark: the encoded protein contains a Zn(2)-Cys(6) binuclear cluster.; Title: similarity to transcriptional regulator Cat8 - Saccharomyces cerevisiae; nucleus; See PMID 7891685; uncharacterized protein 1754087 84589997 An01g07445 Aspergillus niger uncharacterized protein XP_059605895.1 1753743 D 5061 CDS An01g07450 84589998 join(1754277..1754425,1754480..1754999,1755063..1755860,1755937..1756560) II 1 NT_166518.1 Remark: protein is involved in acetamide and acetate utilisation in A. nidulans.; Remark: the cDNA SB011195. p1 possesses additional sequences (the first intron) but because of two stop-codons within this intron and because of the homologies to other proteins this sequences were not added to the ORD coding sequence.; Similarity: the ORF shows similarity to some transcription factors.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; See PMID 9197408; uncharacterized protein 1756560 84589998 An01g07450 Aspergillus niger uncharacterized protein XP_059605896.1 1754277 D 5061 CDS An01g07460 4978488 complement(join(1756913..1757512,1757691..1758029)) II 1 NT_166518.1 Function: the protein is responsible for vegetative incompatibility in Podospora anserina.; Remark: the Podospora anserina protein is N-terminal 800 aa longer than the A. niger protein.; Title: similarity to beta transducin-like protein het-e1 - Podospora anserina; See PMID 7557402; uncharacterized protein 1758029 4978488 An01g07460 Aspergillus niger uncharacterized protein XP_059605897.1 1756913 R 5061 CDS An01g07470 4977452 join(1758987..1759130,1759179..1759220,1759267..1759543,1759589..1759699,1759767..1759913,1759980..1760319,1760396..1760618) II 1 NT_166518.1 Remark: RNaseP of H. sapiens is a ribonucleoprotein that cleaves tRNA precursors to generate the 5' termini of the mature tRNAs.; Similarity: the ORF is longer than RNaseP of H. sapiens and the similarity between the two proteins extends solely over a stretch of ca. 60 amino acids.; Title: weak similarity to Ribonuclease P protein subunit p40 RNaseP - Homo sapiens; See PMID 7514716; uncharacterized protein 1760618 4977452 An01g07470 Aspergillus niger uncharacterized protein XP_059605898.1 1758987 D 5061 CDS An01g07480 4977573 complement(join(1760926..1763444,1763506..1763749,1763818..1764312)) II 1 NT_166518.1 Function: dna2 plays an essential role in Okazaki fragment metabolism in Schizosaccharomyces pombe.; Remark: the Aspergillus protein is N-terminal about 300 aa shorter than the S. pombe homolog.; Title: strong similarity to DNA binding protein dna2p - Schizosaccharomyces pombe; nucleus; See PMID 10880469; uncharacterized protein 1764312 4977573 An01g07480 Aspergillus niger uncharacterized protein XP_059605899.1 1760926 R 5061 CDS An01g07490 84589999 complement(join(1764345..1764461,1764547..1766127)) II 1 NT_166518.1 Title: similarity to hypothetical protein CAF06129.1 - Neurospora crassa; uncharacterized protein 1766127 84589999 An01g07490 Aspergillus niger uncharacterized protein XP_059605900.1 1764345 R 5061 CDS An01g07500 4977354 join(1766817..1767064,1767189..1767276) II 1 NT_166518.1 Title: strong similarity to hypothetical protein CAF06125.1 - Neurospora crassa; uncharacterized protein 1767276 4977354 An01g07500 Aspergillus niger uncharacterized protein XP_001389175.1 1766817 D 5061 CDS An01g07510 4977014 complement(join(1767674..1768030,1768091..1768169,1768224..1768507,1768586..1768678,1768758..1768769)) II 1 NT_166518.1 Catalytic activity: nitrilases catalyze a nitrile + H(2)O <=> a carboxylate + NH(3).; Similarity: the ORF shows similarity to several nitrilases from different species and to the N-terminal part of NitFhit from Caenorhabditis elegans, which displays nitrilase activity.; Title: similarity to nitrilase fusion protein NitFhit - Caenorhabditis elegans; uncharacterized protein 1768769 4977014 An01g07510 Aspergillus niger uncharacterized protein XP_001389176.1 1767674 R 5061 CDS An01g07520 4977175 join(1769055..1769250,1769303..1771986,1772023..1772208) II 1 NT_166518.1 Function: the S. pombe homolog is an essential protein directly or indirectly implicated in mitotic control.; Remark: S. pombe cells disrupted in the dis3+ gene are unable to germinate and fail in cell division.; Title: strong similarity to mitotic control protein dis3p - Schizosaccharomyces pombe; nucleus; See PMID 1944266; uncharacterized protein 1772208 4977175 An01g07520 Aspergillus niger uncharacterized protein XP_059605901.1 1769055 D 5061 CDS An01g07530 4977307 complement(join(1772439..1773749,1773815..1774036)) II 1 NT_166518.1 Function: the M. auratus homolog catalyzes the H+/Lactate-cotransport; facilitates the cellular uptake of lactate, pyruvate and other monocarboxylates.; Localization: integral membrane protein (probable).; Title: similarity to monocarboxylate transporter MCT2 - Mesocricetus auratus; uncharacterized protein 1774036 4977307 An01g07530 Aspergillus niger uncharacterized protein XP_001389178.1 1772439 R 5061 CDS An01g07540 84590000 complement(join(1774408..1774488,1774588..1774711,1774751..1774805,1775407..1775544,1775656..1775739,1775844..1775892)) II 1 NT_166518.1 hypothetical protein 1775892 84590000 An01g07540 Aspergillus niger hypothetical protein XP_059605902.1 1774408 R 5061 CDS An01g07550 4977663 join(1777249..1777886,1777977..1778115,1778170..1778490) II 1 NT_166518.1 Title: similarity to androgen receptor coactivator ARA55 - Homo sapiens; See PMID 10075738; uncharacterized protein 1778490 4977663 An01g07550 Aspergillus niger uncharacterized protein XP_059605903.1 1777249 D 5061 CDS An01g07560 84590001 complement(join(1779034..1779104,1779148..1779370)) II 1 NT_166518.1 hypothetical protein 1779370 84590001 An01g07560 Aspergillus niger hypothetical protein XP_059605904.1 1779034 R 5061 CDS An01g07570 4977244 join(1779531..1779709,1779770..1779886,1779952..1780079,1780134..1780557,1780635..1781028,1781082..1781222) II 1 NT_166518.1 Function: defects in Liz1p of S. pombe blocks cell cycle progression in G2 when ribonucleotide reductase activity is inactivated.; Similarity: the predicted A. niger protein shows strong similarity to Liz1p of S. pombe and other transmembrane transporter proteins.; Title: strong similarity to transmembrane transporter liz1p - Schizosaccharomyces pombe; plasma membrane; See PMID 9950674; uncharacterized protein 1781222 4977244 An01g07570 Aspergillus niger uncharacterized protein XP_059605905.1 1779531 D 5061 CDS An01g07580 4977047 complement(join(1781671..1781823,1781863..1782142,1782242..1782338,1782418..1782605,1782701..1782876)) II 1 NT_166518.1 Remark: protein may be a methyltransferase-like protein similar to human and mouse proteins.; Title: strong similarity to hypothetical protein YDL201w - Saccharomyces cerevisiae; uncharacterized protein 1782876 4977047 An01g07580 Aspergillus niger uncharacterized protein XP_059605906.1 1781671 R 5061 CDS An01g07590 4978335 join(1783196..1783591,1783700..1783775,1783852..1783964) II 1 NT_166518.1 Title: strong similarity to hypothetical protein W02A11.2 - Caenorhabditis elegans; uncharacterized protein 1783964 4978335 An01g07590 Aspergillus niger uncharacterized protein XP_001389184.1 1783196 D 5061 CDS An01g07600 4978438 complement(join(1784195..1784836,1784901..1786317,1786375..1786811,1786885..1786977)) II 1 NT_166518.1 Title: similarity to pax transcription activation domain interacting protein PTIP - Mus musculus; nucleus; See PMID 10908331; uncharacterized protein 1786977 4978438 An01g07600 Aspergillus niger uncharacterized protein XP_059605907.1 1784195 R 5061 CDS An01g07615 4978322 join(1788206..1788415,1788471..1788609,1788671..>1788779) II 1 NT_166518.1 Remark: the ORF is truncated due to the contig border.; Remark: the missing N-terminal coding sequence is encoded in An01g07630 on the adjacent contig.; Title: strong similarity to hypothetical host-specific AK-toxin related protein CAB91703.2 -Neurospora crassa [truncated ORF]; uncharacterized protein 1788779 4978322 An01g07615 Aspergillus niger uncharacterized protein XP_001389187.3 1788206 D 5061 CDS An01g07630 84590002 <1788929..1789810 II 1 NT_166518.1 Remark: the ORF is truncated due to the contig border.; Remark: the missing N-terminal coding sequence is encoded in An01g07615 on the adjacent contig.; Title: strong similarity to hypothetical host-specific AK-toxin related protein CAB91703.2 -Neurospora crassa [truncated ORF]; uncharacterized protein 1789810 84590002 An01g07630 Aspergillus niger uncharacterized protein XP_059603225.1 1788929 D 5061 CDS An01g07640 4978225 complement(join(1790170..1790353,1790414..1790610,1790695..1790930,1791006..1791192,1791279..1791374)) II 1 NT_166518.1 Remark: alternate names = hypothetical protein LPG21w.; Title: similarity to hypothetical membrane protein YPL087w - Saccharomyces cerevisiae; uncharacterized protein 1791374 4978225 An01g07640 Aspergillus niger uncharacterized protein XP_059603226.1 1790170 R 5061 CDS An01g07650 4978276 join(1792669..1792720,1792789..1793684) II 1 NT_166518.1 Remark: substrates of the nematode Onchocerca volvulus proteins are small ions.; Title: similarity to MRS3/MRS4 class mitochondrial solute carrier - Onchocerca volvulus; localisation:mitochondrion; uncharacterized protein 1793684 4978276 An01g07650 Aspergillus niger uncharacterized protein XP_001389189.1 1792669 D 5061 CDS An01g07660 4977488 complement(join(1794055..1794264,1794340..1794405,1794467..1795834)) II 1 NT_166518.1 Remark: protein may be an EF-hand-like calcium-binding protein.; Title: similarity to hypothetical protein B7F18.80 -Neurospora crassa; uncharacterized protein 1795834 4977488 An01g07660 Aspergillus niger uncharacterized protein XP_001389190.1 1794055 R 5061 CDS An01g07670 84590003 join(1795923..1796132,1796213..1796275,1796521..1796568,1796696..1796848) II 1 NT_166518.1 hypothetical protein 1796848 84590003 An01g07670 Aspergillus niger hypothetical protein XP_059603227.1 1795923 D 5061 CDS An01g07680 84590004 complement(join(1798182..1798797,1799128..1799319,1799941..1800092,1800286..1800310,1800393..1800481,1800991..1801044,1801102..1801125,1801229..1801357)) II 1 NT_166518.1 Title: similarity to hypothetical protein encoded by An11g02490 - Aspergillus niger; uncharacterized protein 1801357 84590004 An01g07680 Aspergillus niger uncharacterized protein XP_059603228.1 1798182 R 5061 CDS An01g07690 84590005 complement(join(1802051..1802083,1802180..1802541,1802634..1802705,1802790..1802893,1802986..1803033,1803113..1803249)) II 1 NT_166518.1 Remark: weak partial similarities to human mRNA for alpha-1 chain of collagen IV.; hypothetical protein 1803249 84590005 An01g07690 Aspergillus niger hypothetical protein XP_059603229.1 1802051 R 5061 CDS An01g07700 4977298 complement(join(1803706..1804042,1804094..1804189,1804240..1804622,1804675..1804790,1804896..1805085)) II 1 NT_166518.1 Function: pth11 of M. grisea is involved in host surface recognition.; Remark: pth11 of M. grisea is probably membrane associated.; Similarity: the ORF is about 260 amino acids shorter than pth11 of M. grisea.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529; uncharacterized protein 1805085 4977298 An01g07700 Aspergillus niger uncharacterized protein XP_059603230.1 1803706 R 5061 CDS An01g07710 84590006 join(1806110..1806205,1806315..1806437) II 1 NT_166518.1 Remark: partial similarity to S. coelicolor hydroxyacyl-CoA dehydrogenase (TREMBL:SCHCOADH_5).; hypothetical protein 1806437 84590006 An01g07710 Aspergillus niger hypothetical protein XP_059603231.1 1806110 D 5061 CDS An01g07720 4977846 join(1807029..1807211,1807264..1807390,1807452..1807575,1807629..1808080,1808138..1808394,1808461..1808538) II 1 NT_166518.1 Function: omtB of A. parasiticus converts demethylsterigmatocystin to sterigmatocystin.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Remark: omtB of A. parasiticus belongs to the aflatoxin biosynthetic gene cluster.; Title: strong similarity to O-methyltransferase B omtB - Aspergillus parasiticus; See PMID 6798444; See PMID 10806361; uncharacterized protein 1808538 4977846 An01g07720 Aspergillus niger uncharacterized protein XP_001389196.3 1807029 D 5061 CDS An01g07730 84590007 complement(join(1808995..1809485,1809550..1809712)) II 1 NT_166518.1 Title: weak similarity to precursor of protein TcSL-2 - Toxocara cani; See PMID 7629180; uncharacterized protein 1809712 84590007 An01g07730 Aspergillus niger uncharacterized protein XP_059603232.1 1808995 R 5061 CDS An01g07740 84590008 complement(1810910..1811221) II 1 NT_166518.1 Remark: the ORF is short in length.; hypothetical protein 1811221 84590008 An01g07740 Aspergillus niger hypothetical protein XP_059603233.1 1810910 R 5061 CDS An01g07750 4977877 complement(join(1811653..1811821,1811916..1812082,1812141..1812215,1812331..1812447)) II 1 NT_166518.1 Remark: Alternate names = protein B7F18. 60; Title: similarity to hypothetical prefoldin subunit 1 - Neurospora crassa; uncharacterized protein 1812447 4977877 An01g07750 Aspergillus niger uncharacterized protein XP_059603234.1 1811653 R 5061 CDS An01g07760 4977857 complement(join(1812552..1812781,1812855..1813299,1813415..1813738)) II 1 NT_166518.1 Similarity: shows similarity to several oxygenases.; Title: strong similarity to hypothetical protein F12A12.10 - Arabidopsis thaliana; uncharacterized protein 1813738 4977857 An01g07760 Aspergillus niger uncharacterized protein XP_059603235.1 1812552 R 5061 CDS An01g07765 84590009 1814118..1814450 II 1 NT_166518.1 hypothetical protein 1814450 84590009 An01g07765 Aspergillus niger hypothetical protein XP_059603236.1 1814118 D 5061 CDS An01g07770 4977057 1814765..1815544 II 1 NT_166518.1 Title: strong similarity to hypothetical protein EAA59879.1 - Aspergillus nidulans; uncharacterized protein 1815544 4977057 An01g07770 Aspergillus niger uncharacterized protein XP_001389202.3 1814765 D 5061 CDS An01g07780 84590010 join(1815861..1815989,1816157..1816261) II 1 NT_166518.1 Title: questionable ORF; uncharacterized protein 1816261 84590010 An01g07780 Aspergillus niger uncharacterized protein XP_059603237.1 1815861 D 5061 CDS An01g07790 4977259 join(1816318..1816423,1816516..1817930) II 1 NT_166518.1 Remark: a putative sequencing error results in an premature STOP codon.; putative sequencing error; hypothetical protein [putative sequencing error] 1817930 4977259 An01g07790 Aspergillus niger hypothetical protein [putative sequencing error] XP_059603238.1 1816318 D 5061 CDS An01g07800 84590011 complement(join(1818262..1818349,1818451..1818531,1818658..1819010)) II 1 NT_166518.1 hypothetical protein 1819010 84590011 An01g07800 Aspergillus niger hypothetical protein XP_059603239.1 1818262 R 5061 CDS An01g07810 4977285 join(1819587..1819737,1819796..1819951,1820040..1820415,1820485..1820662) II 1 NT_166518.1 Function: The S. pombe homolog is required for nitrogen starvation-induced sexual development.; Title: strong similarity to protein rcd1p -Schizosaccharomyces pombe; See PMID 9447985; uncharacterized protein 1820662 4977285 An01g07810 Aspergillus niger uncharacterized protein XP_001389206.3 1819587 D 5061 CDS An01g07820 4977954 join(1821692..1821862,1821955..1822052,1822115..1822334,1822392..1823234,1823290..1824504) II 1 NT_166518.1 Title: similarity to hypothetical Pto kinase interactor F28B23.17 - Arabidopsis thaliana; uncharacterized protein 1824504 4977954 An01g07820 Aspergillus niger uncharacterized protein XP_001389207.1 1821692 D 5061 CDS An01g07830 4977920 join(1836372..1836581,1836636..1836710,1836777..1838000) II 1 NT_166518.1 Function: in S. pombe Ste11 protein regulates positively transcription of the mating type genes, matP and matM, and the mei2 gene, which is essential for commitment to meiosis.; Function: in S. pombe expression of ste11 is essential for induction of sexual development, and its ectopic expression stimulates uncontrolled mating and sporulation.; Regulation: in S. pombe methionine and nitrogen starvation reduce the intracellular cAMP pool and induce the expression of at least two cAMP-repressible genes,including fbp1 and ste11.; Similarity: S. pombe ste11 encodes a member of the family of HMG-box proteins.; Similarity: similarity is from central region of predicted A. niger protein to N-terminal 100 aa of S. pombe ste11.; Title: similarity to transcription factor ste11p -Schizosaccharomyces pombe; See PMID 1657709; uncharacterized protein 1838000 4977920 An01g07830 Aspergillus niger uncharacterized protein XP_059599694.1 1836372 D 5061 CDS An01g07840 4977647 complement(join(1839789..1840505,1840559..1840678)) II 1 NT_166518.1 Remark: no transmembrane regions were prdicted for the ORF.; Similarity: similarity of predicted A. niger protein is confined to central region of G. gallus cKv1. 4(m),which is 200 aa longer.; Title: weak similarity to potassium channel Shaker alpha subunit variant cKv1.4(m) - Gallus gallus; See PMID 10095080; uncharacterized protein 1840678 4977647 An01g07840 Aspergillus niger uncharacterized protein XP_001389209.1 1839789 R 5061 CDS An01g07850 4977423 join(1841974..1842000,1842064..1842614,1842691..1842784) II 1 NT_166518.1 Title: similarity to hypothetical protein SPBP23A10.09 - Schizosaccharomyces pombe; uncharacterized protein 1842784 4977423 An01g07850 Aspergillus niger uncharacterized protein XP_059599695.1 1841974 D 5061 CDS An01g07860 4977645 join(1843733..1843964,1844058..1845389,1845442..1845641,1845689..1845922,1845971..1847148,1847198..1847222) II 1 NT_166518.1 Function: the protein also shows similarity to S. hamata shst2 which encodes a high-affinity H+/sulfate cotransporter that mediates the uptake of sulfate by plant roots from low concentrations of sulfate in the soil solution.; Title: strong similarity to hypothetical membrane transport protein YGR125w - Saccharomyces cerevisiae; uncharacterized protein 1847222 4977645 An01g07860 Aspergillus niger uncharacterized protein XP_001389211.1 1843733 D 5061 CDS An01g07870 4978306 join(1852482..1852768,1852836..1853034,1853095..1853296,1853353..1853631,1853686..1854326) II 1 NT_166518.1 Function: sea lamprey neurofilaments (NFs) are unique in being homopolymers of a single 180 kDa subunit (NF-180).; Title: similarity to neurofilament subunit NF-180 -Petromyzon marinus; cytoskeleton; See PMID 7770000; uncharacterized protein 1854326 4978306 An01g07870 Aspergillus niger uncharacterized protein XP_001389212.1 1852482 D 5061 CDS An01g07872 84590012 1854560..1854877 II 1 NT_166518.1 hypothetical protein 1854877 84590012 An01g07872 Aspergillus niger hypothetical protein XP_059599696.1 1854560 D 5061 CDS An01g07890 84590013 1859072..1859254 II 1 NT_166518.1 Function: Disruption of cpcA in A. niger resulted in a strain which is sensitive towards 3-aminotriazole and fails to respond to amino acid starvation.; Gene-ID: cpcA; Remark: cpcA of Aspergillus niger was cloned by complementation of a S. cerevisiae delta gcn4 mutant strain.; See PMID 9004217; transcriptional regulator gene cpcA-Aspergillus niger 1859254 cpcA 84590013 cpcA Aspergillus niger transcriptional regulator gene cpcA-Aspergillus niger XP_059603240.1 1859072 D 5061 CDS An01g07900 84590014 join(1859628..1859652,1859704..>1860420) II 1 NT_166518.1 Gene-ID: cpcA; Remark: the second exon is N-terminal two aminoacids longer than the published sequence.; Remark: two putative frameshift leading to premature STOP codons found.; nucleus; putative frameshift; See PMID 9004217; leucine zipper cpcA-Aspergillus niger [putative frameshift] 1860420 cpcA 84590014 cpcA Aspergillus niger leucine zipper cpcA-Aspergillus niger [putative frameshift] XP_059603241.1 1859628 D 5061 CDS An01g07910 4978237 complement(join(1861711..1862775,1862810..1863550)) II 1 NT_166518.1 EC:6.3.5.4; Title: similarity to glutamine-hydrolyzing asparagine synthase - Arabidopsis thaliana; See PMID 9881155; uncharacterized protein 1863550 4978237 An01g07910 Aspergillus niger uncharacterized protein XP_059603242.1 1861711 R 5061 CDS An01g07920 4977536 join(1864505..1865309,1865362..1865439,1865498..1865673,1865724..1865871,1865941..1866159,1866238..1866349,1866413..1866458) II 1 NT_166518.1 Remark: appearance of novel reticular membrane structures as well as an accumulation of 40- to 50-nm-diameter vesicles suggested that Vps9p may be required for the consumption of transport vesicles containing vacuolar protein precursors.; Title: strong similarity to vacuolar protein sorting-associated protein Vps9 - Saccharomyces cerevisiae; See PMID 8628304; uncharacterized protein 1866458 4977536 An01g07920 Aspergillus niger uncharacterized protein XP_059603243.1 1864505 D 5061 CDS An01g07930 84590015 complement(join(1867178..1868135,1868238..1868587,1868647..1868694)) II 1 NT_166518.1 Title: strong similarity to hypothetical protein encoded by An11g05030 - Aspergillus niger; uncharacterized protein 1868694 84590015 An01g07930 Aspergillus niger uncharacterized protein XP_059603244.1 1867178 R 5061 CDS An01g07940 84590016 complement(join(1869229..1869695,1869752..1869821)) II 1 NT_166518.1 Remark: blastp hits are caused by repetetive sequence motives.; Title: weak similarity to hypothetical protein Y38B5A.a - Caenorhabditis elegans; uncharacterized protein 1869821 84590016 An01g07940 Aspergillus niger uncharacterized protein XP_059603245.1 1869229 R 5061 CDS An01g07950 4977500 1870639..1871439 II 1 NT_166518.1 Title: similarity to hypothetical protein CAD70322.1 - Neurospora crassa; uncharacterized protein 1871439 4977500 An01g07950 Aspergillus niger uncharacterized protein XP_001389220.1 1870639 D 5061 CDS An01g07960 84590017 join(1873110..1873362,1873392..1873667,1873906..1873984,1874040..1874167,1874641..1874708,1875011..1875560,1875697..1875767) II 1 NT_166518.1 Title: strong similarity to hypothetical protein CAD70321.1 - Neurospora crassa; uncharacterized protein 1875767 84590017 An01g07960 Aspergillus niger uncharacterized protein XP_059603246.1 1873110 D 5061 CDS An01g07970 84590018 join(1876573..1877241,1877314..1877373) II 1 NT_166518.1 Title: similarity to hypothetical protein encoded by An06g02140 - Aspergillus niger; uncharacterized protein 1877373 84590018 An01g07970 Aspergillus niger uncharacterized protein XP_059603247.1 1876573 D 5061 CDS An01g07980 4977661 1878439..1878696 II 1 NT_166518.1 Title: strong similarity to EST SEQ ID NO:4248 from patent WO200056762-A2 - Aspergillus niger; uncharacterized protein 1878696 4977661 An01g07980 Aspergillus niger uncharacterized protein XP_001389223.1 1878439 D 5061 CDS An01g07990 4978202 join(1880525..1880838,1881008..1881116) II 1 NT_166518.1 Title: similarity to hypothetical protein encoded by An09g04200 - Aspergillus niger; uncharacterized protein 1881116 4978202 An01g07990 Aspergillus niger uncharacterized protein XP_001389224.3 1880525 D 5061 CDS An01g08000 4977635 join(1881717..1882184,1882276..1886460) II 1 NT_166518.1 Function: het-e1 of P. anserina is involved in vegetative incompatibility.; Remark: co-expression of antagonistic alleles of the unlinked loci het-e and het-c triggers a cell death reaction that prevents the formation of viable heterokaryons between strains that contain incompatible combinations of het-c and het-e alleles.; Remark: het-e1 of P. anserina is transducin-like.; Remark: the reactivity of the het-e1 of P. anserina depends on two functional elements, a GTP-binding domain and several WD40 repeats.; Title: strong similarity to vegetative incompatibility gene het-e1 - Podospora anserina; See PMID 7557402; See PMID 9435787; uncharacterized protein 1886460 4977635 An01g08000 Aspergillus niger uncharacterized protein XP_059603248.1 1881717 D 5061 CDS An01g08010 4978160 join(1888541..1888607,1888661..1888997,1889049..1889556) II 1 NT_166518.1 Function: CCC1 of S. cerevisiae is a transporter that effects the accumulation of iron and Mn(2+) in vacuoles.; Remark: CCC1 of S. cerevisiae is involved in the transfer of iron from the cytosol to the vacuole.; Title: strong similarity to iron and manganese transporter Ccc1 - Saccharomyces cerevisiae; vacuole; See PMID 11390404; uncharacterized protein 1889556 4978160 An01g08010 Aspergillus niger uncharacterized protein XP_001389226.1 1888541 D 5061 CDS An01g08020 4977229 complement(1889744..1890328) II 1 NT_166518.1 hypothetical protein 1890328 4977229 An01g08020 Aspergillus niger hypothetical protein XP_001389227.3 1889744 R 5061 CDS An01g08030 4977859 join(1892159..1892673,1892826..1893143,1893258..1893276,1893344..1893367) II 1 NT_166518.1 Pathway: the protein of patent W55817 from S. roseofulvus is involved in the polyketide pathway of frenolicin biosynthesis.; Similarity: frnR of S. roseofulvus encodes a putative cyclase/dehydrase with similarity to beta-lactamase.; Similarity: shows homology to the protein patent database entry GENESEQPROT:W55817.; Similarity: the protein sequence of patent W55817 is identical to the product of the frnR gene of the frenolicin biosynthesis gene cluster of S. roseofulvus.; Title: similarity to frenolicin gene cluster protein 18 from patent JP10094395-A - Streptomyces roseofulvus; uncharacterized protein 1893367 4977859 An01g08030 Aspergillus niger uncharacterized protein XP_001389228.3 1892159 D 5061 CDS An01g08040 4977153 complement(join(1894197..1894867,1894980..1895713,1895841..1896079)) II 1 NT_166518.1 Similarity: the C-terminus contains a domain with similarity to the RNA polymerase II mediator subunit ROX3 of S. cerevisiae (PubMed 1656237;8995225).; Similarity: the N-terminus shows deliberate matches to a variety of serine-rich proteins from diverse species.; Similarity: the N-terminus shows weak similarity to the proline-rich protein VRP1 (verprolin) of S. cerevisiae involved in cytoskeleton organization (PubMed 7968536).; Title: similarity to hypothetical protein B11E5.120 - Neurospora crassa; uncharacterized protein 1896079 4977153 An01g08040 Aspergillus niger uncharacterized protein XP_059603249.1 1894197 R 5061 CDS An01g08050 4977435 complement(join(1896882..1897962,1898025..1898787,1898844..1899342,1899462..1899608)) II 1 NT_166518.1 Function: UaY of A. nidulans binds to the consensus sequence 5'-tcggnnnnnnccga-3'.; Function: UaY of A. nidulans mediates the induction of a number of unlinked genes involved in purine utilization.; Similarity: UaY of A. nidulans contains a Zn(2)-Cys(6), fungal-type binuclear cluster domain.; Title: similarity to positive regulator of purine utilisation uaY - Aspergillus nidulans; See PMID 7602582; See PMID 7729421; uncharacterized protein 1899608 4977435 An01g08050 Aspergillus niger uncharacterized protein XP_001389230.1 1896882 R 5061 CDS An01g08060 4977664 join(1902036..1902194,1902371..1902561,1902714..1902763,1902986..1903065,1903195..1903610,1903662..1904267,1904353..1905220) II 1 NT_166518.1 Function: UaY of A. nidulans binds to the consensus sequence 5'-tcggnnnnnnccga-3'.; Function: UaY of A. nidulans mediates the induction of a number of unlinked genes involved in purine utilization.; Similarity: UaY of A. nidulans contains a Zn(2)-Cys(6), fungal-type binuclear cluster domain.; Title: similarity to positive regulator of purine utilisation uaY - Aspergillus nidulans; See PMID 7602582; See PMID 7729421; uncharacterized protein 1905220 4977664 An01g08060 Aspergillus niger uncharacterized protein XP_059603250.1 1902036 D 5061 CDS An01g08070 84590019 complement(join(1905622..1905796,1905871..1905987,1906749..1906948,1907025..1907042,1907122..1907185,1907280..1907394,1907469..1907550)) II 1 NT_166518.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons.; Title: questionable ORF; uncharacterized protein 1907550 84590019 An01g08070 Aspergillus niger uncharacterized protein XP_059603251.1 1905622 R 5061 CDS An01g08080 4978449 join(1907646..1907696,1907762..1907832,1907974..1908254,1908326..1908516,1908569..1908851,1908907..1909046,1909098..1909228,1909281..1909635,1909687..1909803,1909863..1909902,1909966..1911008) II 1 NT_166518.1 Title: strong similarity to hypothetical protein SPAC32A11.02c - Schizosaccharomyces pombe; uncharacterized protein 1911008 4978449 An01g08080 Aspergillus niger uncharacterized protein XP_059603252.1 1907646 D 5061 CDS An01g08090 4977950 complement(join(1911429..1911625,1911807..1912764,1912828..1912925,1913006..1913471)) II 1 NT_166518.1 Catalytic activity: aminoimidazole ribonucleotide carboxylases catalyse the reaction,1-(5-phospho-D-ribosyl)-5-amino-4-imidazolecarbox ylate => 1-(5-phospho-D-ribosyl)-5-aminoimidazole + CO2.; Function: C. glabrata ADE2 catalyses a central step in de novo purine biosynthesis.; Remark: the C. glabrata ADE2 gene encodes aminoimidazole ribonucleotide (AIR) carboxylase.; Title: strong similarity to aminoimidazole ribonucleotide carboxylase ADE2 - Candida glabrata; See PMID 9500840; See PMID 9602176; uncharacterized protein 1913471 4977950 An01g08090 Aspergillus niger uncharacterized protein XP_001389234.1 1911429 R 5061 CDS An01g08100 4977249 1914199..1915239 II 1 NT_166518.1 Title: similarity to hypothetical protein CAE81998.1 - Neurospora crassa; uncharacterized protein 1915239 4977249 An01g08100 Aspergillus niger uncharacterized protein XP_001389235.3 1914199 D 5061 CDS An01g08110 4977805 complement(1915740..1919327) II 1 NT_166518.1 Remark: atp7a (Menkes protein) in Mus musculus is localised in the plasma membrane of liver peroxisomes.; Title: strong similarity to Cu(2+)-transporting P-type ATPase Atp7a - Mus musculus; plasma membrane; See PMID 9687544; See PMID 10332039; uncharacterized protein 1919327 4977805 An01g08110 Aspergillus niger uncharacterized protein XP_001389236.1 1915740 R 5061 CDS An01g08120 4977598 join(1920870..1921128,1921180..1921877) II 1 NT_166518.1 Remark: ACOB is one of the preinduction genes (acts before induction of sporulation) in Aspergillus nidulans.; Title: strong similarity to protein ACOB -Aspergillus nidulans; See PMID 7551046; uncharacterized protein 1921877 4977598 An01g08120 Aspergillus niger uncharacterized protein XP_001389237.1 1920870 D 5061 CDS An01g08130 4977744 complement(join(1922604..1922840,1922894..1923620,1923681..1923835)) II 1 NT_166518.1 Remark: expression of RAX1 from S. cerevisiae is required for the delivery of Rax2-GFP to the cell surface (see PUBMED entry 11110666).; Similarity: the predicted A. niger protein shows strong similarity to hypothetical proteins SPAC23G3. 05c from S. pombe and YOR301w (RAX1) from S. cerevisiae.; Title: strong similarity to hypothetical protein SPAC23G3.05c - Schizosaccharomyces pombe; uncharacterized protein 1923835 4977744 An01g08130 Aspergillus niger uncharacterized protein XP_001389238.1 1922604 R 5061 CDS An01g08140 84590020 join(1923938..1924042,1924120..1924458) II 1 NT_166518.1 Remark: blastp hits are caused by repetetive sequence motives.; hypothetical protein 1924458 84590020 An01g08140 Aspergillus niger hypothetical protein XP_059603253.1 1923938 D 5061 CDS An01g08150 4977769 1925965..1926714 II 1 NT_166518.1 Catalytic activity: carbonyl reductases catalyse the reaction, R-CHOH-R' + NADP+ = R-CO-R' + NADPH; Function: human carbonyl reductase is envolved in prostaglandin- and leukotrine-metabolism in H. sapiens.; Title: similarity to carbonyl reductase CBR - Homo sapiens; See PMID 1921984; uncharacterized protein 1926714 4977769 An01g08150 Aspergillus niger uncharacterized protein XP_001389240.1 1925965 D 5061 CDS An01g08160 4977062 complement(join(1926931..1926951,1927015..1928046,1928107..1928160,1928220..1928305,1928526..1928622,1928655..1928669)) II 1 NT_166518.1 Complex: in S. cerevisiae Gcn5 with Ada and Hac1is part of a large multimeric histone acetyltransferase complex.; Function: S. cerevisiae Gcn5 is required for transcriptional activation.; Remark: GCN5 is a lys14 specific histone H3 acetyltransferase in S. cerevisiae.; Title: strong similarity to histone acetyltransferase Gcn5 - Saccharomyces cerevisiae; nucleus; See PMID 10430845; See PMID 1396595; uncharacterized protein 1928669 4977062 An01g08160 Aspergillus niger uncharacterized protein XP_059603254.1 1926931 R 5061 CDS An01g08170 4977686 1929271..1930401 II 1 NT_166518.1 Complex: yeast Rad1-Rad10 form a complex.; Function: in yeast Rad1-Rad10 form a complex with endonuclease activity, incising damaged DNA strands on the 5'-side of the lesion.; Title: strong similarity to DNA repair endonuclease rad1p - Schizosaccharomyces pombe; nucleus; See PMID 9660799; See PMID 10915862; See PMID 1563349; uncharacterized protein 1930401 4977686 An01g08170 Aspergillus niger uncharacterized protein XP_001389242.1 1929271 D 5061 CDS An01g08180 4977032 complement(join(1930641..1930649,1930737..1934426,1934490..1934573,1934635..1934736)) II 1 NT_166518.1 Complex: RINT-1 specifically binds to Rad50 only during late S and G(2)/M phases.; Complex: S. cerevisiae RAD50 forms different complexes to act specifically in DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiosis.; Complex: the Mre11-Rad50 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific exonuclease activity.; Function: the RAD50 gene of S. cerevisiae is required for chromosome synapsis and recombination during meiosis and for repair of DNA damage during vegetative growth.; Title: strong similarity to DNA-repair ATPase Rad50 - Saccharomyces cerevisiae; nucleus; See PMID 2659437; See PMID 10892749; See PMID 10915866; See PMID 11029422; See PMID 11096100; uncharacterized protein 1934736 4977032 An01g08180 Aspergillus niger uncharacterized protein XP_001389243.3 1930641 R 5061 CDS An01g08190 84590021 join(1935001..1935058,1935142..1935215,1935319..1935435,1935515..1935553,1935638..1935709,1936000..1936193,1936505..1936559,1936841..1936966,1937040..1937093) II 1 NT_166518.1 Similarity: shows weak similarity to several bacterial aminopeptidases.; Title: weak similarity to hypothetical aminopeptidase pepA - Mycobacterium tuberculosis; uncharacterized protein 1937093 84590021 An01g08190 Aspergillus niger uncharacterized protein XP_059603255.1 1935001 D 5061 CDS An01g08200 84590022 complement(join(1937323..1937481,1937528..1937719)) II 1 NT_166518.1 Remark: similarity of predicted A. niger protein to human breast tumour-associated protein 71 was discovered using blastp against the PATENTPROT database.; Remark: the protein sequence of human breast tumour-associated protein 71 is a fragment derived from an EST.; Title: weak similarity to EST derived breast tumour-associated protein 71 from patent DE19813835-A1 -Homo sapiens; uncharacterized protein 1937719 84590022 An01g08200 Aspergillus niger uncharacterized protein XP_059603256.1 1937323 R 5061 CDS An01g08210 4977332 join(1937899..1939056,1939162..1939336,1939409..1939455) II 1 NT_166518.1 Function: F. solani PBP is essential for induction of the cutinase gene.; Similarity: F. solani PBP and the predicted A. niger protein share a fungal Cys6Zn2 binuclear cluster DNA-binding domain.; Title: strong similarity to transcription factor PBP - Fusarium solani; nucleus; See PMID 7744822; uncharacterized protein 1939455 4977332 An01g08210 Aspergillus niger uncharacterized protein XP_059603257.1 1937899 D 5061 CDS An01g08220 4978078 complement(join(1940196..1940359,1940418..1940566,1940622..1940924,1940978..1941061,1941184..1941275)) II 1 NT_166518.1 Title: strong similarity to hypothetical membrane protein YNL010w - Saccharomyces cerevisiae; uncharacterized protein 1941275 4978078 An01g08220 Aspergillus niger uncharacterized protein XP_059603258.1 1940196 R 5061 CDS An01g08230 4977313 join(1941940..1942045,1942136..1942282,1942352..1942422,1942482..1943462) II 1 NT_166518.1 Similarity: similarity is between the N-terminal regions of the predicte A. niger protein and S. cerevisiae GCD14.; Similarity: the N-terminal region of the predicted A. niger protein shows similarity to different methyltransferases.; Title: weak similarity to methyltransferase Gcd14 -Saccharomyces cerevisiae; See PMID 10330157; uncharacterized protein 1943462 4977313 An01g08230 Aspergillus niger uncharacterized protein XP_001389248.1 1941940 D 5061 CDS An01g08240 4977186 complement(join(1944587..1945032,1945072..1945773,1945835..1946657)) II 1 NT_166518.1 Complex: by two-hybrid assay and in vitro S. cerevisiae yTaf(II)19p and Not5p interact.; Complex: the S. cerevisiae Ccr4-Not complex (1 mDa in size), consists of the proteins Ccr4, Caf1, and Not1 to Not5.; Function: S. cerevisiae CCR4 is required for positive and negative regulation of a number of genes involved in nonfermentative growth, including glucose-repressible ADH2.; Function: the S. cerevisiae Ccr4-Not complex likely represses transcription by inhibiting factors more specifically required for promoters lacking a TATA sequence like the yTaf(II)19 subunit of TFIID.; Regulation: the transcriptional activation ability of S. cerevisiae CCR4 is glucose regulated.; Title: similarity to transcription regulator Ccr4 -Saccharomyces cerevisiae; nucleus; See PMID 8007957; See PMID 10490603; See PMID 10864925; uncharacterized protein 1946657 4977186 An01g08240 Aspergillus niger uncharacterized protein XP_059603259.1 1944587 R 5061 CDS An01g08250 84590023 join(1946659..1946731,1946808..1946879,1946964..1947238) II 1 NT_166518.1 Remark: blastp shows significant similarity (43% identity) between predicted A. niger protein and A. sulcata LWamide but due to shortness of both peptides the probability is low (p=1,2).; Remark: literature concerning LWamide of A. sulcata is not available via PubMed.; Title: similarity to precursor of LWamide neuropeptide - Anemonia sulcata; uncharacterized protein 1947238 84590023 An01g08250 Aspergillus niger uncharacterized protein XP_059603260.1 1946659 D 5061 CDS An01g08260 84590024 complement(join(1947256..1947574,1947608..1947679,1947736..1947794,1947885..1947954,1948638..1948699,1948806..1948868,1949474..1949602)) II 1 NT_166518.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons.; Remark: blastp with the predicted A. niger protein only retrieves random hits.; Title: questionable ORF; uncharacterized protein 1949602 84590024 An01g08260 Aspergillus niger uncharacterized protein XP_059603261.1 1947256 R 5061 CDS An01g08265 84590025 join(1949923..1950095,1950194..1950292,1950763..1950910) II 1 NT_166518.1 hypothetical protein 1950910 84590025 An01g08265 Aspergillus niger hypothetical protein XP_059603262.1 1949923 D 5061 CDS An01g08270 84590026 join(1951411..1951498,1951611..1952098) II 1 NT_166518.1 hypothetical protein 1952098 84590026 An01g08270 Aspergillus niger hypothetical protein XP_059603263.1 1951411 D 5061 CDS An01g08280 4977985 1952121..1953320 II 1 NT_166518.1 Title: strong similarity to hypothetical protein CAC28582.1 - Neurospora crassa; uncharacterized protein 1953320 4977985 An01g08280 Aspergillus niger uncharacterized protein XP_001389254.1 1952121 D 5061 CDS An01g08290 84590027 complement(join(1953830..1953846,1953919..1954029,1954156..1954201)) II 1 NT_166518.1 Title: weak similarity to hypothetical protein CG6115 - Drosophila melanogaster; uncharacterized protein 1954201 84590027 An01g08290 Aspergillus niger uncharacterized protein XP_059603264.1 1953830 R 5061 CDS An01g08300 4978150 join(1955069..1955425,1955514..1955517,1955649..1955818,1955878..1956234) II 1 NT_166518.1 Title: similarity to hypothetical conserved protein VC1938 - Vibrio cholerae; uncharacterized protein 1956234 4978150 An01g08300 Aspergillus niger uncharacterized protein XP_059603265.1 1955069 D 5061 CDS An01g08310 4977242 1960276..1963395 II 1 NT_166518.1 Title: strong similarity to hypothetical protein CAC28577.2 - Neurospora crassa; uncharacterized protein 1963395 4977242 An01g08310 Aspergillus niger uncharacterized protein XP_059603266.1 1960276 D 5061 CDS An01g08360 84590028 complement(join(1966173..1967783,1967842..1968234,1968284..1968901)) II 1 NT_166518.1 Remark: the similarity is only in the hydroxyproline-rich region.; Title: similarity to hydroxyproline-rich microfilarial sheath protein - Brugia malayi; See PMID 7637719; uncharacterized protein 1968901 84590028 An01g08360 Aspergillus niger uncharacterized protein XP_059603267.1 1966173 R 5061 CDS An01g08370 4977187 complement(1969276..1970364) II 1 NT_166518.1 Remark: transcription factor TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements.; Title: similarity to transcription factor IIIC 95K chain Tfc1 - Saccharomyces cerevisiae; See PMID 2052571; See PMID 1737746; uncharacterized protein 1970364 4977187 An01g08370 Aspergillus niger uncharacterized protein XP_001389259.1 1969276 R 5061 CDS An01g08380 4977103 complement(join(1971055..1971803,1971867..1971907,1971959..1972026)) II 1 NT_166518.1 Remark: Dibenzothiophene (DBT) is representative of a broad range of sulfur heterocycles found in petroleum that are recalcitrant to desulfurization via HDS.; Remark: Rhodococcus sp. strain IGTS8 has the ability to convert DBT to 2-hydroxybiphenyl (HBP) with the release of inorganic sulfur. The conversion of DBT to HBP is catalyzed by a multienzyme pathway consisting of two monooxygenases and a desulfinase.; Remark: the development of biocatalytic desulfurization of petroleum fractions may allow its use in place of conventional hydrodesulfurization (HDS).; Title: similarity to NADH-dependent FMN oxydoreductase dszD - Rhodococcus erythropolis; See PMID 9634856; uncharacterized protein 1972026 4977103 An01g08380 Aspergillus niger uncharacterized protein XP_001389260.1 1971055 R 5061 CDS An01g08390 4977708 1972340..1972840 II 1 NT_166518.1 Remark: mitochondrial ribosomal proteins (MRPs) are the counterparts in that organelle of the cytoplasmic ribosomal proteins in the host.; Remark: the mitochondrial ribosome of the yeast S. cerevisiae contains 13 large subunit proteins.; Title: similarity to ribosomal protein of the large subunit Mrpl36 - Saccharomyces cerevisiae; See PMID 9151978; See PMID 9445368; mitochondrial 54S ribosomal protein bL31m 1972840 4977708 An01g08390 Aspergillus niger mitochondrial 54S ribosomal protein bL31m XP_001389261.1 1972340 D 5061 CDS An01g08400 4977565 complement(join(1973313..1973459,1973522..1974124,1974173..1974553,1974604..1975082,1975159..1975218,1975280..1975313)) II 1 NT_166518.1 Remark: VPSS/GRD2, encodes a hydrophilic protein similar to human sorting nexin-1, a protein involved in trafficking of the epidermal growth factor receptor.; Remark: Vps5p is required for retrieval of membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus.; Title: strong similarity to sorting nexin-1-like protein Vps5 - Saccharomyces cerevisiae; See PMID 9175702; uncharacterized protein 1975313 4977565 An01g08400 Aspergillus niger uncharacterized protein XP_001389262.1 1973313 R 5061 CDS An01g08410 4977357 complement(join(1975898..1976015,1976077..1976552,1976623..1976757)) II 1 NT_166518.1 Remark: patent EP892050-A2.; Remark: useful as diagnostic reagents and for prevention and treatment of inflammatory diseases, cancer and Parkinson's disease.; Title: strong similarity to polypeptide HFIZG53 from patent EP892050-A2 - Homo sapiens; uncharacterized protein 1976757 4977357 An01g08410 Aspergillus niger uncharacterized protein XP_001389263.1 1975898 R 5061 CDS An01g08420 4977847 join(1977728..1977853,1977916..1978198,1978255..1978385,1978455..1979108,1979165..1979659) II 1 NT_166518.1 Remark: Secretory proteins become folded by the action of a number of molecular chaperones soon after they enter the endoplasmic reticulum (ER). In mammalian cells,the ER membrane protein calnexin has been shown to be a molecular chaperone involved in the folding of secretory proteins and in the assembly of cell surface receptor complexes.; Title: strong similarity to calcium-binding protein precursor cnx1p - Schizosaccharomyces pombe; See PMID 7621821; See PMID 10597630; See PMID 10878246; uncharacterized protein 1979659 4977847 An01g08420 Aspergillus niger uncharacterized protein XP_001389264.1 1977728 D 5061 CDS An01g08430 4978332 join(1980563..1981310,1981388..1982025,1982102..1982518) II 1 NT_166518.1 Catalytic activity: 2-Methyl-3-oxopropanoate + CoA + NAD+ = Propanoyl-CoA + CO2 + NADH.; Pathway: valine, leucine and isoleucine degradation; propanoate metabolism.; Remark: MMSDH clearly belongs to a superfamily of aldehyde dehydrogenases and is closely related to betaine aldehyde dehydrogenase, 2-hydroxymuconic semialdehyde dehydrogenase, and class 1 and 2 aldehyde dehydrogenases.; Remark: the enzyme is active with malonate semialdehyde and consumes both stereoisomers of methylmalonate semialdehyde, implicating a single semialdehyde dehydrogenase in the catabolism of valine,thymine, and compounds catabolized by way of beta-alanine.; Title: strong similarity to methylmalonate-semialdehyde dehydrogenase MMSDH - Rattus norvegicus; See PMID 2768248; See PMID 1527093; uncharacterized protein 1982518 4978332 An01g08430 Aspergillus niger uncharacterized protein XP_001389265.1 1980563 D 5061 CDS An01g08440 4978459 complement(join(1983019..1983141,1983199..1983648,1983746..1983787,1983844..1983897)) II 1 NT_166518.1 Remark: weak similarity to the C-terminal domain of the glucan-binding protein - Streptococcus mutans.; Title: strong similarity to hypothetical protein encoded by An13g02980 - Aspergillus niger; uncharacterized protein 1983897 4978459 An01g08440 Aspergillus niger uncharacterized protein XP_001389266.1 1983019 R 5061 CDS An01g08450 4978506 join(1984772..1984945,1985024..1986358) II 1 NT_166518.1 Catalytic activity: ATP + a Protein = ADP + a Phosphoprotein.; Remark: babo is not required during embryogenesis but is essential for proper pupation and adult viability. Among findings on babo function, babo primarily regulates cell proliferation and has only minimal effects on patterning.; Title: weak similarity to baboon babo - Drosophila melanogaster; deleted EC_number 2.7.1.37; uncharacterized protein 1986358 4978506 An01g08450 Aspergillus niger uncharacterized protein XP_059603268.1 1984772 D 5061 CDS An01g08460 4978324 complement(join(1986568..1986588,1986656..1988043,1988104..1988443)) II 1 NT_166518.1 Function: Alg12 from S. cerevisiae is part of the dolichol pathway.; Function: Alg12 from S. cerevisiae is responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2.; Function: The S. cerevisiae alg12 deletion mutant accumulates oligosaccharide lipid with a Man(7)GlcNAc(2) oligosaccharide.; Title: strong similarity to the mannosyltransferase Alg12 - Saccharomyces cerevisiae; See PMID 10336995; See PMID 12460943; uncharacterized protein 1988443 4978324 An01g08460 Aspergillus niger uncharacterized protein XP_059603269.1 1986568 R 5061 CDS An01g08465 4978316 join(1988694..1988706,1988814..1988873,1988946..1989056,1989167..1989222) II 1 NT_166518.1 Title: strong similarity to hypothetical protein SPAC19A8.09 - Schizosaccharomyces pombe; uncharacterized protein 1989222 4978316 An01g08465 Aspergillus niger uncharacterized protein XP_059603270.1 1988694 D 5061 CDS An01g08470 4978128 complement(join(1990289..1992346,1992452..1992682,1992907..1992942)) II 1 NT_166518.1 Catalytic activity: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol.; Remark: acts on esters formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin. also acts on AMP-ubiquitin.; Title: strong similarity to ubiquitin carboxyl-terminal hydrolase UBP1 - Pichia anomala; See PMID 1883836; See PMID 10635554; See PMID 10933821; uncharacterized protein 1992942 4978128 An01g08470 Aspergillus niger uncharacterized protein XP_059603271.1 1990289 R 5061 CDS An01g08490 4977172 join(1997656..1998948,1999013..1999294) II 1 NT_166518.1 Catalytic activity: ATP + L-histidine + tRNA(His) = AMP + pyrophosphate + L-histidyl-tRNA(His).; Localization: might encode the cytoplasmic and mitochondrial protein.; Pathway: aminoacyl-tRNA biosynthesis.; Remark: histidyl-tRNA synthetase (HisRS) is responsible for the synthesis of histidyl-transfer RNA,which is essential for the incorporation of histidine into proteins.; Title: strong similarity to histidine--tRNA ligase Hts1 - Saccharomyces cerevisiae; See PMID 3521891; See PMID 10430027; uncharacterized protein 1999294 4977172 An01g08490 Aspergillus niger uncharacterized protein XP_001389271.3 1997656 D 5061 CDS An01g08500 4977212 complement(join(1999496..1999522,1999647..1999668,1999739..2001089,2001148..2001328)) II 1 NT_166518.1 Remark: COQ6 encodes a protein which is involved in the biosynthesis of coenzyme Q (Tzagoloff and Dieckmann,1990).; Similarity: to E. coli ubiH and visC proteins.; Title: strong similarity to monooxygenase Coq6 -Saccharomyces cerevisiae; See PMID 10669875; See PMID 10987383; uncharacterized protein 2001328 4977212 An01g08500 Aspergillus niger uncharacterized protein XP_001389272.3 1999496 R 5061 CDS An01g08510 4977025 join(2001884..2002111,2002240..2002374) II 1 NT_166518.1 Remark: the N-terminal part shows similarity to many different proteins of various organisms.; hypothetical protein 2002374 4977025 An01g08510 Aspergillus niger hypothetical protein XP_001389273.1 2001884 D 5061 CDS An01g08520 4978029 complement(join(2002624..2003805,2003882..2004175)) II 1 NT_166518.1 Complex: when expressed in COS7 cells,epitope-tagged sorting nexins SNX1, SNX1A, SNX2, and SNX4 coimmunoprecipitated with receptor tyrosine kinases for EGF, platelet-derived growth factor, and insulin.; Function: SNX4 of S. cerevisiae is a sorting nexin involved in protein sorting.; Remark: the protein contains a conserved domain of approximately 100 amino acids, which was termed the phox homology (PX) domain.; Remark: the systematic genename of SNX4 is YJL036w .; Title: strong similarity to sorting nexin protein Snx4 - Saccharomyces cerevisiae; See PMID 9819414; uncharacterized protein 2004175 4978029 An01g08520 Aspergillus niger uncharacterized protein XP_001389274.1 2002624 R 5061 CDS An01g08530 4977223 complement(join(2004659..2005430,2005481..2007243)) II 1 NT_166518.1 Catalytic activity: cleavage of -Lys-Arg+ and Arg-Arg+ bonds to process yeast alpha-factor pheromone and killer toxin precursors.; Gene-ID: kexB; Mapping: aglC from A. niger is mapped to chromosome II; see list from DSM.; Remark: Secreted yields of foreign proteins may be enhanced in filamentous fungi through the use of translational fusions in which the target protein is fused to an endogenous secreted carrier protein. The fused proteins are usually separated in vivo by cleavage of an engineered Kex2 endoprotease recognition site at the fusion junction.; Remark: a Ca2+-activated subtilisin homologue,containing Cys near the active site His, and inhibited by p-mercuribenzoate. Similar enzymes occur in mammals.; Remark: the differences in the sequence are caused by strain variations or sequencing errors.; See PMID 1367012; See PMID 10618249; kexin precursor kexB-Aspergillus niger 2007243 kexB 4977223 kexB Aspergillus niger kexin precursor kexB-Aspergillus niger XP_001389275.1 2004659 R 5061 CDS An01g08540 4977965 complement(join(2008303..2009031,2009087..2009461,2009548..2009762,2009840..2009948)) II 1 NT_166518.1 Remark: K3OH is involved in metabolism of tryptophan to kynurenic acid (KYNA), which has anticonvulsant and neuroprotective activities, and quinolinic acid (QUIN) which is neurotoxic, and is a target for inhibition of QUIN synthesis.; Remark: patent WO9802553.; Title: strong similarity to kynurenine 3-hydroxylase K3OH from patent WO9802553 - Rattus sp.; See PMID 10672018; See PMID 11080194; uncharacterized protein 2009948 4977965 An01g08540 Aspergillus niger uncharacterized protein XP_001389276.1 2008303 R 5061 CDS An01g08550 4977234 complement(join(2011265..2011548,2011617..2011864,2011925..2012158,2012220..2013001)) II 1 NT_166518.1 Remark: ATR1 allowes gcn4 mutant strains to grow in the presence of aminotriazole.; Title: strong similarity to aminotriazole resistance protein Atr1 - Saccharomyces cerevisiae; plasma membrane; See PMID 3280970; See PMID 9046086; uncharacterized protein 2013001 4977234 An01g08550 Aspergillus niger uncharacterized protein XP_001389277.1 2011265 R 5061 CDS An01g08560 4977694 join(2016580..2019462,2019518..2019643,2019699..2019901,2019957..2020252,2020327..2021075) II 1 NT_166518.1 Remark: the ORF encoded protein is N-terminal extended in comparison to S. cerevisiae YGR266w.; Title: similarity to hypothetical protein YGR266w -Saccharomyces cerevisiae; uncharacterized protein 2021075 4977694 An01g08560 Aspergillus niger uncharacterized protein XP_059603272.1 2016580 D 5061 CDS An01g08570 4977808 join(2021816..2021837,2021918..2022817,2022877..2023058) II 1 NT_166518.1 Catalytic activity: NADPH + oxidized thioredoxin <=> NADP(+) + reduced thioredoxin.; Complex: the thioredoxin reductase TrxB from Penicillium chrysogenum forms a homodimer.; Title: strong similarity to thioredoxin reductase TrxB - Penicillium chrysogenum; cytoplasm; See PMID 8106340; uncharacterized protein 2023058 4977808 An01g08570 Aspergillus niger uncharacterized protein XP_001389279.1 2021816 D 5061 CDS An01g08580 4977735 complement(2023631..2026513) II 1 NT_166518.1 Catalytic activity: N1-acetylspermine + O(2) + H(2)O <=> N1-acetylspermidine + 3-amino-propanal + H(2)O(2).; Remark: the polyamine oxidase PAO utilises an FAD cofactor to catalyse the oxidation of the secondary amino groups of spermine and spermidine.; Similarity: the closest manual homologue PAO from Z. mays shows an E-val. of 1e-25.; Title: similarity to polyamine oxidase PAO - Zea mays; See PMID 9598979; See PMID 1366693; See PMID 10368296; uncharacterized protein 2026513 4977735 An01g08580 Aspergillus niger uncharacterized protein XP_001389280.3 2023631 R 5061 CDS An01g08590 4977165 complement(join(2028439..2028796,2028858..2029277,2029328..2029572)) II 1 NT_166518.1 Title: strong similarity to hypothetical protein YKR088c - Saccharomyces cerevisiae; uncharacterized protein 2029572 4977165 An01g08590 Aspergillus niger uncharacterized protein XP_001389281.3 2028439 R 5061 CDS An01g08600 4977700 join(2031574..2032505,2032580..2033311,2033363..2033921) II 1 NT_166518.1 Title: similarity to hypothetical protein At2g26280 - Arabidopsis thaliana; uncharacterized protein 2033921 4977700 An01g08600 Aspergillus niger uncharacterized protein XP_001389282.1 2031574 D 5061 CDS An01g08610 4977454 complement(join(2034254..2034964,2035026..2035246,2035367..2035406)) II 1 NT_166518.1 Catalytic activity: Citrate <=> acetate + oxaloacetate.; Title: strong similarity to citrate lyase beta chain CitE - Klebsiella pneumoniae; cytoplasm; See PMID 7830578; uncharacterized protein 2035406 4977454 An01g08610 Aspergillus niger uncharacterized protein XP_001389283.1 2034254 R 5061 CDS An01g08620 4977747 join(2035977..2036119,2036243..2036529,2036597..2036745) II 1 NT_166518.1 Title: strong similarity to hypothetical protein SPBC2A9.05c - Schizosaccharomyces pombe; uncharacterized protein 2036745 4977747 An01g08620 Aspergillus niger uncharacterized protein XP_001389284.1 2035977 D 5061 CDS An01g08630 4977438 complement(join(2037258..2037405,2037470..2038335,2038400..2038963)) II 1 NT_166518.1 Induction: the mrcA gene product from Streptomyces lavendulae is inducible by mitomycin C.; Title: similarity to protein involved in mitomycin C resistance McrA - Streptomyces lavendulae; See PMID 7517396; See PMID 8917108; uncharacterized protein 2038963 4977438 An01g08630 Aspergillus niger uncharacterized protein XP_001389285.1 2037258 R 5061 CDS An01g08640 4977569 join(2040891..2041393,2041454..2041991) II 1 NT_166518.1 Catalytic activity: 4 porphobilinogen+H(2)O<=>hydroxymethylbilane+4 NH(3).; Function: the hydroxymethylbilane synthase Hem3 from S. cerevisiae catalyzes the tetrapolymerisation of the monopyrrole PBG into the hydroxymethylbilane preuroporphyrinogen.; Induction: the promotor of the S. cer. HEM3 gene has a binding site for Hap2p/Hap3p/Hap4p complex.; Pathway: Hem3 S. cer. is involved in the yeast porphyrin biosynthesis.; Remark: the hydroxymethylbilane synthase from S. cerevisiae is alternativly named porphobilinogen deaminase or pre-uroporphyrinogen synthase.; Title: strong similarity to hydroxymethylbilane synthase Hem3 - Saccharomyces cerevisiae; See PMID 1508149; uncharacterized protein 2041991 4977569 An01g08640 Aspergillus niger uncharacterized protein XP_059603273.1 2040891 D 5061 CDS An01g08650 4977592 2042585..2044102 II 1 NT_166518.1 hypothetical protein 2044102 4977592 An01g08650 Aspergillus niger hypothetical protein XP_001389287.1 2042585 D 5061 CDS An01g08660 4977858 join(<2044539..2045408,2045508..2045591) II 1 NT_166518.1 Remark: N-terminally truncated ORF due to the end of contig.; Title: similarity to ankyrin Ank - Drosophila melanogaster [truncated ORF]; See PMID 7937942; uncharacterized protein 2045591 4977858 An01g08660 Aspergillus niger uncharacterized protein XP_001389288.3 2044539 D 5061 CDS An01g08670 4978161 join(2045810..2045843,2046088..2046134,2046227..2046334,2046469..2046522,2046633..2046671,2046729..2046899,2047163..2047574,2047664..2047782,2047876..2048181) II 1 NT_166518.1 Similarity: the similarities of the ORF encoded protein to other proteins are mainly based on repetitive structures.; Title: similarity to nucleolin C23 - Cricetulus griseus; nucleus; See PMID 3470736; uncharacterized protein 2048181 4978161 An01g08670 Aspergillus niger uncharacterized protein XP_059599697.1 2045810 D 5061 CDS An01g08680 84590029 complement(join(2048547..2048722,2048784..2048984,2049042..2049511,2049681..2049981,2050084..2050506,2050557..2050738,2050817..2050866)) II 1 NT_166518.1 Title: weak similarity to regulator protein Gal4 -Saccharomyces cerevisiae; uncharacterized protein 2050866 84590029 An01g08680 Aspergillus niger uncharacterized protein XP_059599698.1 2048547 R 5061 CDS An01g08690 4977856 join(2051467..2051844,2051905..2052452,2052512..2052800,2052867..2053208) II 1 NT_166518.1 Catalytic activity: Benzoate + NADPH + O(2) <=> 4-hydroxybenzoate + NADP(+) + H(2)O.; Cofactor: Iron, Tetrahydrobiopterin.; Pathway: the benzoate 4-monooxygenase cytochrome P450 53 (BphA) from A. niger is involved in the phenylalanine metabolism.; Title: strong similarity to benzoate 4-monooxygenase cytochrome P450 53 bphA - Aspergillus niger; See PMID 2250647; uncharacterized protein 2053208 4977856 An01g08690 Aspergillus niger uncharacterized protein XP_001389291.1 2051467 D 5061 CDS An01g08700 4978289 join(2053782..2054030,2054094..2054588,2054637..2055316,2055369..2055438,2055797..2055877) II 1 NT_166518.1 Function: the CYHR protein from C. maltosa transforms S. cerevisiae to cycloheximide resistance.; Similarity: the ORF encoded protein shows the strongest similarity to the protein of patent JP09009966-A,but this patent does not describe its function clearly enough.; Title: strong similarity to cycloheximide resistance protein CYHR - Candida maltosa; See PMID 1628836; uncharacterized protein 2055877 4978289 An01g08700 Aspergillus niger uncharacterized protein XP_059599699.1 2053782 D 5061 CDS An01g08710 4978226 join(2056856..2056922,2057026..2057140,2057186..2057266,2057320..2057450,2057504..2057634,2057714..2057812,2057889..2058096,2058149..2058296,2058344..2058420,2058476..2058536,2058590..2058666,2058731..2058802,2058869..2059047) II 1 NT_166518.1 Remark: the ORF encoded protein has a unusual gene structure and it is much shorter than cnjB from Tetrahymena thermophila.; Similarity: the similarities of the ORF encoded protein to other proteins are mainly based on repetitive structures.; Title: similarity to protein cnjB - Tetrahymena thermophila; See PMID 8233798; uncharacterized protein 2059047 4978226 An01g08710 Aspergillus niger uncharacterized protein XP_001389293.1 2056856 D 5061 CDS An01g08720 4978295 complement(join(2059498..2059557,2059634..2061011,2061071..2065560)) II 1 NT_166518.1 Remark: the CDR1 gene from C. albicans was cloned by functional complementation of a PDR5 null mutant of S. cerevisiae.; Similarity: the ORF encoded protein shows the strongest similarity to the AtrA transporter from A. nidulans, which is not enough functionally characterized.; Title: strong similarity to multidrug resistance ATP-binding cassette transporter CDR1 - Candida albicans; See PMID 7614555; uncharacterized protein 2065560 4978295 An01g08720 Aspergillus niger uncharacterized protein XP_001389294.3 2059498 R 5061 CDS An01g08730 4978039 complement(join(2066611..2066636,2066766..2066779,2066940..2066989,2067480..2068160,2068212..2068460,2068625..2069446)) II 1 NT_166518.1 Title: weak similarity to gamma-tocopherol methyltransferase from patent WO9904622-A1 - Arabidopsis sp.; uncharacterized protein 2069446 4978039 An01g08730 Aspergillus niger uncharacterized protein XP_001389295.3 2066611 R 5061 CDS An01g08740 4977196 2069805..2071502 II 1 NT_166518.1 Function: the protein product of MJ0720 from Methanococcus jannaschii was found to be alpha-isopropylmalate dehydrogenase (LeuB) and was found to catalyze the NAD-dependent decarboxylation of one isomer of DL-threo-isopropylmalate to 2-ketoisocaproate; thus, it is involved in the biosynthesis of leucine.; Remark: LeuB normally is the gene name for beta-isopropylmalate dehydrogenases (EC 1. 1. 1. 85; e. g. LeuB Corynebacterium glutamicum.; Title: similarity to protein MJ0720 - Methanococcus jannaschii; See PMID 10940051; uncharacterized protein 2071502 4977196 An01g08740 Aspergillus niger uncharacterized protein XP_059599700.1 2069805 D 5061 CDS An01g08750 84590030 complement(join(2072809..2072943,2073004..2073151,2073231..2073610)) II 1 NT_166518.1 hypothetical protein 2073610 84590030 An01g08750 Aspergillus niger hypothetical protein XP_059599701.1 2072809 R 5061 CDS An01g08760 4977051 join(2074334..2074514,2074548..2074628,2074690..2074731,2074801..2075248,2075437..2075982,2076097..2076112,2076266..2076311,2076621..2076988) II 1 NT_166518.1 Remark: the Flu1 gene product from C. albicans complements the fluconazole hypersusceptibility of a S. cerevisiae pdr5 mutant, lacking the ABC (ATP-binding cassette) transporter gene PDR5.; Title: similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353; uncharacterized protein 2076988 4977051 An01g08760 Aspergillus niger uncharacterized protein XP_059599702.1 2074334 D 5061 CDS An01g08770 84590031 complement(join(2078586..2078696,2078773..2079187,2079299..2079595,2080138..2080175,2080302..2080367)) II 1 NT_166518.1 hypothetical protein 2080367 84590031 An01g08770 Aspergillus niger hypothetical protein XP_059599703.1 2078586 R 5061 CDS An01g08780 4977987 join(2081473..2081692,2081764..2081952,2082030..2082966,2083032..2083308) II 1 NT_166518.1 Induction: the HXT1 gene from S. cerevisiae is repressed at high glucose concentrations.; Remark: alternate name for S. cerevisiae Hxt1: YHR094C,Hor4.; Title: strong similarity to high affinity hexose transporter Hxt1 - Saccharomyces cerevisiae; See PMID 9151960; See PMID 2046678; uncharacterized protein 2083308 4977987 An01g08780 Aspergillus niger uncharacterized protein XP_001389300.1 2081473 D 5061 CDS An01g08790 4977491 join(2086052..2086200,2086250..2086561,2086614..2087205,2087272..2087850) II 1 NT_166518.1 Similarity: the ORF encoded protein shows the strongest similarity to the S. pombe hypothetical proteins SPAC1B3. 16c and SPAC1B3. 15c.; Title: strong similarity to 4-hydroxyphenylacetate transporter hpaX - Escherichia coli; See PMID 9315705; uncharacterized protein 2087850 4977491 An01g08790 Aspergillus niger uncharacterized protein XP_001389301.1 2086052 D 5061 CDS An01g08800 4977373 complement(join(2088470..2088487,2088542..2088963,2089022..2089526,2089746..2089886,2089931..2089969,2090081..2090083)) II 1 NT_166518.1 Catalytic activity: ATP + L-glutamate + NH(3) <=> ADP + phosphate + L-glutamine.; Pathway: the glutamine synthetase (GLN1) from S. cerevisiae is involved in glutamate metabolism and nitrogen metabolism.; Remark: the DNA sequence of the ORF is nearly identical to the A. niger EST BE759130.; Similarity: the ORF encoded protein shows stong similarity to the protein described in patent WO8704462-A.; Title: strong similarity to glutamine synthase Gln1 - Saccharomyces cerevisiae; See PMID 2865193; uncharacterized protein 2090083 4977373 An01g08800 Aspergillus niger uncharacterized protein XP_059599704.1 2088470 R 5061 CDS An01g08810 84590032 join(2090307..2090340,2090493..2090797) II 1 NT_166518.1 hypothetical protein 2090797 84590032 An01g08810 Aspergillus niger hypothetical protein XP_059599705.1 2090307 D 5061 CDS An01g08820 84590033 complement(join(2096473..2097132,2097186..2098844)) II 1 NT_166518.1 Title: strong similarity to hypothetical protein CAD71053.1 - Neurospora crassa; uncharacterized protein 2098844 84590033 An01g08820 Aspergillus niger uncharacterized protein XP_059599706.1 2096473 R 5061 CDS An01g08830 4978009 join(2099360..2099446,2099521..2099963,2099998..2100056,2100119..2100149,2100205..2100271) II 1 NT_166518.1 Title: similarity to hypothetical protein CAD70783.1 - Neurospora crassa; uncharacterized protein 2100271 4978009 An01g08830 Aspergillus niger uncharacterized protein XP_059599707.1 2099360 D 5061 CDS An01g08840 4977428 complement(join(2100463..2101106,2101173..2101707,2101823..2101849)) II 1 NT_166518.1 Similarity: the ORF encoded protein also shows strong similarities to B. subtilis conserved hypothetical proteins yoqW and yoaM.; Similarity: the similarities of the ORF encoded protein with a score less than 58. 6 (e. val:1e-07) are mainly based on repetitive structures.; Title: strong similarity to hypothetical protein YMR114c - Saccharomyces cerevisiae; uncharacterized protein 2101849 4977428 An01g08840 Aspergillus niger uncharacterized protein XP_001389306.1 2100463 R 5061 CDS An01g08850 4977902 complement(join(2103306..2103731,2103994..2104311,2104476..2104602,2104818..2104897)) II 1 NT_166518.1 Similarity: the ORF encoded protein and the Aspergillus nidulans CpcB protein are homologues of the activated protein kinase C receptor RACK1 from Rattus norvegicus.; Similarity: the ORF encoded protein shows also very stong similarity to the human WD-repeat protein described in patent WO9521252-A2.; Title: strong similarity to Gbeta like protein cpcB - Aspergillus nidulans; See PMID 10931303; 40S ribosomal protein RACK1 2104897 4977902 An01g08850 Aspergillus niger 40S ribosomal protein RACK1 XP_001389307.1 2103306 R 5061 CDS An01g08860 4977740 complement(join(2105340..2105788,2105856..2106315)) II 1 NT_166518.1 Title: strong similarity to hypothetical protein 12F11.240 - Neurospora crassa; uncharacterized protein 2106315 4977740 An01g08860 Aspergillus niger uncharacterized protein XP_001389308.1 2105340 R 5061 CDS An01g08870 4977487 complement(join(2107007..2107025,2107100..2107400,2107502..2107628,2107794..2107982)) II 1 NT_166518.1 Complex: the Erv25 protein from S. cerevisiae forms a protein complex with Emp24 (another component of COPII-coated vesicles) that can be isolated after chemical cross-linking.; Remark: alternate name for S. cerevisiae Erv25: YML012w.; Similarity: the ORF encoded protein shows also strong similarity to the Haemonchus contortus protein described in patent DE19704024-A1.; Title: strong similarity to component of COPII-coated vesicles Erv25 - Saccharomyces cerevisiae; intracellular transport vesicles; See PMID 8900179; See PMID 10704443; uncharacterized protein 2107982 4977487 An01g08870 Aspergillus niger uncharacterized protein XP_001389309.3 2107007 R 5061 CDS An01g08880 4978372 complement(join(2108713..2110047,2110107..2112380)) II 1 NT_166518.1 Remark: alternate names for S. cerevisiae MUC1 gene: FLO11 or YIR019c.; Remark: there are no hints for any Muc1 1,4-alpha-glucosidase activity in the literature.; Similarity: the Muc1 protein from S. cerevisiae is a mucin-like protein.; Similarity: the similarities of the ORF encoded protein to Muc1 from S. cerevisiae and the other proteins are mainly based on repetitive structures.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; uncharacterized protein 2112380 4978372 An01g08880 Aspergillus niger uncharacterized protein XP_001389310.3 2108713 R 5061 CDS An01g08890 4978410 complement(2118297..2118968) II 1 NT_166518.1 hypothetical protein 2118968 4978410 An01g08890 Aspergillus niger hypothetical protein XP_001389311.3 2118297 R 5061 CDS An01g08900 4977293 2122665..2124356 II 1 NT_166518.1 Function: the Aspergillus nidulans wetA gene is required for synthesis of cell wall layers that make asexual spores (conidia) impermeable.; Title: strong similarity to regulator protein wetA -Aspergillus nidulans; See PMID 1986246; See PMID 2180753; uncharacterized protein 2124356 4977293 An01g08900 Aspergillus niger uncharacterized protein XP_001389312.1 2122665 D 5061 CDS An01g08910 4977322 complement(join(2125276..2125667,2125880..2125952)) II 1 NT_166518.1 Title: weak similarity to chromodomain-helicase-DNA-binding protein CHD-1 - Mus musculus; See PMID 7739555; See PMID 8460153; uncharacterized protein 2125952 4977322 An01g08910 Aspergillus niger uncharacterized protein XP_059599708.1 2125276 R 5061 CDS An01g08920 4977909 join(2126589..2126755,2126817..2128458) II 1 NT_166518.1 Remark: Scp1='S. cerevisiae CalPonin'.; Similarity: the n-terminal part of the ORF encoded protein (~200aa) shows strong similarity to the hypothetical protein Scp1=YOR367W from S. cerevisiae, the c-terminal the ORF encoded protein is highly repetitve. This repetitve part shows similarity to e. g. the mouse 'mena' protein Pubmed (8861907).; Title: similarity to hypothetical protein Scp1 -Saccharomyces cerevisiae; uncharacterized protein 2128458 4977909 An01g08920 Aspergillus niger uncharacterized protein XP_001389314.1 2126589 D 5061 CDS An01g08930 4978504 complement(join(2129012..2130792,2131082..2131130)) II 1 NT_166518.1 Title: weak similarity to hypothetical RNA binding protein BAA83714.1 - Homo sapiens; uncharacterized protein 2131130 4978504 An01g08930 Aspergillus niger uncharacterized protein XP_059599709.1 2129012 R 5061 CDS An01g08950 4977160 join(2133521..2133551,2133613..2133734,2133810..2134255,2134323..2134887) II 1 NT_166518.1 Remark: in C. albicans two very similar iron permeases has been discovered: CaFTR1 and CaFTR2. Mutants lacking CaFTR1 but not CaFTR2 exhibited a severe growth defect in iron-deficient medium and were unable to establish systemic infection in mice.; Title: strong similarity to high-affinity iron permease CaFTR2 - Candida albicans; See PMID 10807578; uncharacterized protein 2134887 4977160 An01g08950 Aspergillus niger uncharacterized protein XP_001389316.1 2133521 D 5061 CDS An01g08960 4977031 2135775..2137616 II 1 NT_166518.1 Function: the Fet1, CaFet1 gene products from S. cerevisiae and from C. albicans are iron transporter multicopper ferroxidases required for ferrous iron high affinity uptake (TC 9. A. 10).; Similarity: the ORF encoded protein shows also strong similarity to the S. cerevisae multicopper oxidase Fet3 (Pubmed 7836366;8293473).; Title: strong similarity to iron transport multicopper oxidase Fet3 - Candida albicans; See PMID 10517594; uncharacterized protein 2137616 4977031 An01g08960 Aspergillus niger uncharacterized protein XP_001389317.1 2135775 D 5061 CDS An01g08970 84590034 complement(join(2138184..2139523,2139634..2139722,2139768..2139790)) II 1 NT_166518.1 Title: weak similarity to tropomyosin I - Drosophila melanogaster; See PMID 3079761; See PMID 3038522; uncharacterized protein 2139790 84590034 An01g08970 Aspergillus niger uncharacterized protein XP_059599710.1 2138184 R 5061 CDS An01g08980 4977451 complement(join(2140518..2140565,2140626..2140984,2141155..2141287)) II 1 NT_166518.1 Similarity: the ORF encoded protein shows strongest similarity to the S. cerevisiae protein of unknown function Orm1 (YGR038w).; Title: strong similarity to membrane protein NHMP1 from patent WO9833817-A1 - Homo sapiens; uncharacterized protein 2141287 4977451 An01g08980 Aspergillus niger uncharacterized protein XP_001389319.3 2140518 R 5061 CDS An01g08990 4977797 join(2142596..2142823,2142876..2143988,2144054..2144929) II 1 NT_166518.1 Similarity: the similarities of the ORF encoded protein to the cnjB protein from T. thermophila and to other proteins are mainly based on repetitive structures.; Title: similarity to protein cnjB - Tetrahymena thermophila; See PMID 8233798; uncharacterized protein 2144929 4977797 An01g08990 Aspergillus niger uncharacterized protein XP_059599711.1 2142596 D 5061 CDS An01g09000 4977570 complement(join(2145119..2145343,2145426..2145597,2145679..2145888,2145947..2145951)) II 1 NT_166518.1 Similarity: the ORF encoded protein shows also similarities to some hypothetical phosphoglycolate phosphatases (EC 3. 1. 3. 18).; Title: strong similarity to hypothetical protein YOR131c - Saccharomyces cerevisiae; uncharacterized protein 2145951 4977570 An01g09000 Aspergillus niger uncharacterized protein XP_001389321.3 2145119 R 5061 CDS An01g09010 4978264 2146626..2147489 II 1 NT_166518.1 Title: weak similarity to gastric mucin clone PGM-2A - Sus scrofa; See PMID 7755593; uncharacterized protein 2147489 4978264 An01g09010 Aspergillus niger uncharacterized protein XP_001389322.1 2146626 D 5061 CDS An01g09020 4977736 complement(join(2147641..2147835,2147908..2148544,2148664..2148797)) II 1 NT_166518.1 Title: strong similarity to hypothetical protein ymaE - Bacillus subtilis; uncharacterized protein 2148797 4977736 An01g09020 Aspergillus niger uncharacterized protein XP_059599712.1 2147641 R 5061 CDS An01g09030 4977881 complement(join(2149391..2149546,2149607..2151030,2151057..2153157,2153250..>2154359)) II 1 NT_166518.1 Remark: the ORF is N-terminal truncated due to border of contig.; Title: strong similarity to hypothetical protein CAD11387.1 - Neurospora crassa [truncated ORF]; uncharacterized protein 2154359 4977881 An01g09030 Aspergillus niger uncharacterized protein XP_059599713.1 2149391 R 5061 CDS An01g09040 4977425 complement(join(2157968..2158216,2158284..2158544,2158601..2159076,2159132..2159377,2159443..2160031)) II 1 NT_166518.1 Function: DEAD-box family RNA-helicases are involved in nuclear and mitochondrial splicing processes, RNA editing, rRNA processing, translation initiation, nuclear mRNA export, and mRNA degradation (see also the DEAD-box database at http://www. columbia. edu/~ej67/dbhome. htm).; Function: DEAD-box family RNA-helicases manipulate RNA in a manner that requires nucleoside triphosphates and have been shown to unwind purified RNA duplexes.; Function: at least one DEAD-box family protein,NPH-II from vaccinia virus, can effectively catalyze protein displacement from RNA and thereby participate in the structural reorganization of ribonucleoprotein assemblies.; Similarity: DEAD-box family RNA-helicases are highly conserved, howver only for few members of the family actual helicase activity has been proven e. g. not for MrDb.; Title: strong similarity to DEAD box protein MrDb -Homo sapiens; See PMID 10322435; See PMID 11141562; See PMID 8861962; uncharacterized protein 2160031 4977425 An01g09040 Aspergillus niger uncharacterized protein XP_001389325.1 2157968 R 5061 CDS An01g09050 4977281 join(2166188..2166560,2166627..2168488) II 1 NT_166518.1 Function: High levels of Ca 2+ added to the medium could reverse the effects of the spray and frost mutants in N. crassa (http://www. fgsc. net/asilo99/posterabs1. htm).; Function: N. crassa spray mutants initially grow as colonies that are flat on the surface, and then aerial mycelium fans upward (http://www. fgsc. net/compend/s. html).; Remark: data has not yet been published and is available via http://www. fgsc. net.; Title: similarity to calcium-related protein spray -Neurospora crassa; uncharacterized protein 2168488 4977281 An01g09050 Aspergillus niger uncharacterized protein XP_001389326.1 2166188 D 5061 CDS An01g09060 84590035 complement(join(2169449..2169789,2170003..2170131,2170190..2170290,2170480..2170493)) II 1 NT_166518.1 Function: human U1 snRNP protein C is a part of the splicosome involved in pre-mRNA processing.; Function: the splicosome forms, when a number of small nuclear ribonucleoprotein particles (snRNPs) bind sequentially to the pre-mRNA.; Title: strong similarity to U1 snRNP protein C -Homo sapiens; nucleus; See PMID 10322216; uncharacterized protein 2170493 84590035 An01g09060 Aspergillus niger uncharacterized protein XP_059603274.1 2169449 R 5061 CDS An01g09070 84590036 complement(2171000..2172061) II 1 NT_166518.1 Remark: similarity to W96322 was retrieved using blastx against the GENESEQPROT protein database.; Title: weak similarity to inducible nitric oxide synthase from patent WO9906059-A2 - Homo sapiens; uncharacterized protein 2172061 84590036 An01g09070 Aspergillus niger uncharacterized protein XP_059603275.1 2171000 R 5061 CDS An01g09080 84590037 complement(join(2174585..2174624,2174822..2174916,2175083..2175320,2175371..2175855,2175924..2176097)) II 1 NT_166518.1 Similarity: similarity is between the central regions of the predicted A. niger protein and S. pombe TFIIH chain p47.; Title: weak similarity to transcription factor TFIIH chain p47 - Schizosaccharomyces pombe; See PMID 10077189; uncharacterized protein 2176097 84590037 An01g09080 Aspergillus niger uncharacterized protein XP_059603276.1 2174585 R 5061 CDS An01g09090 84590038 2176327..2176794 II 1 NT_166518.1 Title: strong similarity to hypothetical protein CAD11379.1 - Neurospora crassa; uncharacterized protein 2176794 84590038 An01g09090 Aspergillus niger uncharacterized protein XP_059603277.1 2176327 D 5061 CDS An01g09100 4977045 complement(join(2180319..2180381,2180440..2180754,2180820..2181587)) II 1 NT_166518.1 Function: A. oryzae ArpA null mutants showed poor growth and hyper-branched mycelia, as well as a nuclear distribution defect.; Function: Actin-related proteins (Arps) participate in a diverse array of cellular processes. They modulate assembly of conventional actin, contribute to microtubule-based motility catalyzed by dynein, and serve as integral components of large protein complexes required for gene expression.; Function: in A. oryzae overexpression of the ArpA gene causes a defect in nuclear migration into elongating hyphae of germlings.; Title: strong similarity to actin-related protein arpA - Aspergillus oryzae; cytoskeleton; See PMID 10611965; See PMID 10628858; uncharacterized protein 2181587 4977045 An01g09100 Aspergillus niger uncharacterized protein XP_001389331.1 2180319 R 5061 CDS An01g09110 4977468 complement(join(2182261..2182341,2182403..2182475,2182533..2182671,2182736..2183075)) II 1 NT_166518.1 Title: similarity to hypothetical protein encoded by B23L21.360 - Neurospora crassa; uncharacterized protein 2183075 4977468 An01g09110 Aspergillus niger uncharacterized protein XP_059603278.1 2182261 R 5061 CDS An01g09120 4977228 join(2183199..2183243,2183322..2183979,2184056..2184641,2184837..2184969) II 1 NT_166518.1 Title: strong similarity to hypothetical protein encoded by B23L21.370 - Neurospora crassa; mitochondrial 37S ribosomal protein mS35 2184969 4977228 An01g09120 Aspergillus niger mitochondrial 37S ribosomal protein mS35 XP_001389333.3 2183199 D 5061 CDS An01g09130 84590039 complement(join(2185246..2185337,2185426..2185449,2185666..2186647)) II 1 NT_166518.1 Title: weak similarity to hypothetical photoreceptor membrane-associated protein trp - Drosophila melanogaster; uncharacterized protein 2186647 84590039 An01g09130 Aspergillus niger uncharacterized protein XP_059603279.1 2185246 R 5061 CDS An01g09140 4978012 complement(join(2186714..2186794,2186863..2187306)) II 1 NT_166518.1 hypothetical protein 2187306 4978012 An01g09140 Aspergillus niger hypothetical protein XP_001389334.3 2186714 R 5061 CDS An01g09150 84590040 join(2187440..2187545,2187689..2187816) II 1 NT_166518.1 hypothetical protein 2187816 84590040 An01g09150 Aspergillus niger hypothetical protein XP_059603280.1 2187440 D 5061 CDS An01g09160 4977319 complement(join(2187887..2188141,2188238..2188401,2188492..2188528,2188829..2188897,2188947..2189528,2189586..2193182,2193254..2193562)) II 1 NT_166518.1 Similarity: hZFH shows significant similarity to some proteins of the Snf2-like family, known to act as transcriptional regulators for multiple genes.; Title: similarity to hypothetical zinc-finger helicase hZFH - Homo sapiens; uncharacterized protein 2193562 4977319 An01g09160 Aspergillus niger uncharacterized protein XP_059603281.1 2187887 R 5061 CDS An01g09170 4977716 2193993..2195486 II 1 NT_166518.1 Title: similarity to hypothetical gene At2g19870 -Arabidopsis thaliana; uncharacterized protein 2195486 4977716 An01g09170 Aspergillus niger uncharacterized protein XP_001389338.1 2193993 D 5061 CDS An01g09180 4977590 complement(join(2195930..2199130,2199191..2199334,2199396..2199422,2199522..2199641)) II 1 NT_166518.1 Complex: ISW2p of S. cerevisiae forms a two-subunit complex with Itc1p.; Function: S. cerevisiae Isw2 complex represses transcription of early meiotic genes during mitotic growth in a parallel pathway to Rpd3-Sin3 histone deacetylase complex.; Function: the Isw2 complex functions at Ume6-dependent and -independent loci to create DNase I-inaccessible chromatin structure by regulating the positioning or placement of nucleosomes.; Function: the Isw2 complex functions mainly in repression of transcription in a parallel pathway with the Sin3-Rpd3 complex.; Localization: in vegetatively growing diploid cells,the Isw2 protein is cytoplasmic, whereas in cells entering sporulation Isw2p accumulates in the nucleus.; Phenotype: the isw2 homozygous deletant diploid strain was blocked in the G(1) phase of the cell cycle,unable to execute the premeiotic DNA replication and progress through the nuclear meiotic division cycle.; Remark: ISW2p/Itc1p interacts efficiently with both naked DNA and nucleosomal arrays in an ATP-independent manner.; Similarity: the predicted A. niger protein shows similarity to the ISW2 (Imitation Switch gene) protein of S. cerevisiae, which belongs to the superfamily II of DNA/RNA helicases (SNF2 family). the systematic name of ISW2 is YOR304w.; Title: strong similarity to Isw2 - Saccharomyces cerevisiae; See PMID 10090725; See PMID 10620773; See PMID 11081629; See PMID 11238944; See PMID 11533234; uncharacterized protein 2199641 4977590 An01g09180 Aspergillus niger uncharacterized protein XP_059603282.1 2195930 R 5061 CDS An01g09190 4977789 2200352..2201140 II 1 NT_166518.1 Title: weak similarity to hypothetical protein encoded by SPAC6B12.14c - Schizosaccharomyces pombe; uncharacterized protein 2201140 4977789 An01g09190 Aspergillus niger uncharacterized protein XP_001389340.1 2200352 D 5061 CDS An01g09210 4977154 join(2202161..2202233,2202302..2202743,2202817..2204284) II 1 NT_166518.1 Title: similarity to clathrin-associated adaptor complex assembly protein AP47 - Mus musculus; See PMID 10640811; uncharacterized protein 2204284 4977154 An01g09210 Aspergillus niger uncharacterized protein XP_059603283.1 2202161 D 5061 CDS An01g09220 4977340 complement(join(2204487..2205219,2205278..2205363,2205420..2205821)) II 1 NT_166518.1 Title: weak similarity to tyrosinase melC2 -Streptomyces lincolnensis; uncharacterized protein 2205821 4977340 An01g09220 Aspergillus niger uncharacterized protein XP_001389342.1 2204487 R 5061 CDS An01g09230 84590041 complement(join(2206148..2206295,2206382..2206439,2206477..2206606,2207016..2207094,2207146..2207197,2207233..2207338,2207412..2207582)) II 1 NT_166518.1 hypothetical protein 2207582 84590041 An01g09230 Aspergillus niger hypothetical protein XP_059603284.1 2206148 R 5061 CDS An01g09240 4977174 join(2208031..2208127,2208173..2208237,2208340..2208445,2208493..2208547,2208713..2208811,2208864..2208935,2208982..2209300) II 1 NT_166518.1 Remark: PTH11 is a pathogenicity gene predicted to encode a novel transmembrane protein. pth11 mutants are nonpathogenic and it is suggested that the protein is volved in host surface recognition by functioning as an upstream effector of appressorium differentiation.; Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529; uncharacterized protein 2209300 4977174 An01g09240 Aspergillus niger uncharacterized protein XP_059603285.1 2208031 D 5061 CDS An01g09250 4977680 complement(join(2209520..2209980,2210063..2210289,2210369..2210442)) II 1 NT_166518.1 Catalytic activity: 2-acetolactate + CO(2) <=> 2 pyruvate.; Pathway: synthesis of branched chain aminoacids.; Title: similarity to acetolactate synthase precursor ALS - Schizosaccharomyces pombe; uncharacterized protein 2210442 4977680 An01g09250 Aspergillus niger uncharacterized protein XP_059603286.1 2209520 R 5061 CDS An01g09260 4977155 complement(join(2212082..2212449,2212509..2213308,2213431..2213661,2213760..2213863)) II 1 NT_166518.1 Catalytic activity: An aldehyde + NAD(P)(+) + H(2)O <=> an acid + NAD(P)H.; Title: strong similarity to aldehyde dehydrogenase (NADP+) - Homo sapiens; uncharacterized protein 2213863 4977155 An01g09260 Aspergillus niger uncharacterized protein XP_059603287.1 2212082 R 5061 CDS An01g09270 4977120 complement(join(2214708..2215068,2215131..2215683,2215738..2216080,2216136..2216291,2216354..2216557)) II 1 NT_166518.1 Catalytic activity: isocitrate <=> succinate + glyoxylate.; Title: strong similarity to isocitrate lyase acuD -Aspergillus nidulans; uncharacterized protein 2216557 4977120 An01g09270 Aspergillus niger uncharacterized protein XP_001389347.1 2214708 R 5061 CDS An01g09280 84590042 complement(join(2216873..2216935,2217010..2217108,2217415..2217481,2217563..2217612)) II 1 NT_166518.1 hypothetical protein 2217612 84590042 An01g09280 Aspergillus niger hypothetical protein XP_059603288.1 2216873 R 5061 CDS An01g09290 4978122 complement(join(2218796..2218922,2218997..2220735,2220799..2220920,2220988..2221063,2221137..2221262)) II 1 NT_166518.1 Title: strong similarity to neutral trehalase treB -Aspergillus nidulans; uncharacterized protein 2221262 4978122 An01g09290 Aspergillus niger uncharacterized protein XP_001389349.1 2218796 R 5061 CDS An01g09300 4977693 complement(join(2222434..2222710,2222766..2222809,2222861..2223575,2223631..2223745,2223811..2224147,2224292..2224445,2224485..2224677,2224744..2224880,2224959..2225079,2225136..2225172)) II 1 NT_166518.1 Remark: C-terminal half: high similaritiy to trk-transporters.; Remark: Mol. Microbiol. 37:671-679(2000).; Remark: a splice site was detected upstream of the START codon.; Title: similarity to high-affinity potassium uptake transporter trk1 - Schwanniomyces occidentalis; uncharacterized protein 2225172 4977693 An01g09300 Aspergillus niger uncharacterized protein XP_059603289.1 2222434 R 5061 CDS An01g09310 4977437 complement(join(2226083..2226302,2226367..2226670,2226746..2226980,2227054..2227083)) II 1 NT_166518.1 Title: similarity to beta-ketoacyl reductase rhlG -Pseudomonas aeruginosa; uncharacterized protein 2227083 4977437 An01g09310 Aspergillus niger uncharacterized protein XP_001389351.1 2226083 R 5061 CDS An01g09320 4977473 2227799..2228803 II 1 NT_166518.1 Title: similarity to hypothetical protein YHL013c -Saccharomyces cerevisiae; uncharacterized protein 2228803 4977473 An01g09320 Aspergillus niger uncharacterized protein XP_001389352.1 2227799 D 5061 CDS An01g09330 4977815 complement(join(2228905..2229261,2229332..2229409,2229440..2229835)) II 1 NT_166518.1 Remark: Methyl chloride transferase catalyzes the synthesis of methyl chloride from S-adenosine-L-methionine and chloride ion.; Title: strong similarity to methyl chloride transferase BMCT - Batis maritima; See PMID 9789006; uncharacterized protein 2229835 4977815 An01g09330 Aspergillus niger uncharacterized protein XP_059603290.1 2228905 R 5061 CDS An01g09340 84590043 complement(join(2229967..2230144,2230198..2230303,2230451..2230545,2230604..2230653)) II 1 NT_166518.1 hypothetical protein 2230653 84590043 An01g09340 Aspergillus niger hypothetical protein XP_059603291.1 2229967 R 5061 CDS An01g09350 4977129 join(2231526..2231910,2231972..2232981,2233085..2233381) II 1 NT_166518.1 Title: similarity to hypothetical membrane protein YBR043c - Saccharomyces cerevisiae; uncharacterized protein 2233381 4977129 An01g09350 Aspergillus niger uncharacterized protein XP_001389355.1 2231526 D 5061 CDS An01g09360 84590044 complement(join(2233585..2234072,2234271..2234422,2234477..2234535,2234579..2234798,2234997..2235153,2235274..2235509,2235606..2235664,2236177..2236250,2236305..2236404)) II 1 NT_166518.1 hypothetical protein 2236404 84590044 An01g09360 Aspergillus niger hypothetical protein XP_059603292.1 2233585 R 5061 CDS An01g09370 84590045 complement(join(2236456..2236551,2236668..2236778)) II 1 NT_166518.1 hypothetical protein 2236778 84590045 An01g09370 Aspergillus niger hypothetical protein XP_059603293.1 2236456 R 5061 CDS An01g09380 4978296 join(2237015..2237282,2237396..2241894) II 1 NT_166518.1 Remark: protein possibly involved in attachment of the cellulosome to the cell surface.; Title: similarity to hypothetical S-layer protein -Clostridium thermocellum; uncharacterized protein 2241894 4978296 An01g09380 Aspergillus niger uncharacterized protein XP_059603294.1 2237015 D 5061 CDS An01g09390 4978151 complement(join(2242430..2243716,2243770..2244119,2244178..2244196,2244256..2244420)) II 1 NT_166518.1 Catalytic activity: 5-L-Glutamyl)-peptide + an Amino acid = Peptide +5-L-Glutamyl amino acid; Complex: the purified enzyme gamma-Glutamyltranspeptidase from Pseudomonas is composed of two nonidentical subunits.; Remark: processing of the precursor protein to its subunits is probably temperature-dependent.; Title: strong similarity to gamma-Glutamyltranspeptidase - Pseudomonas aeruginosa; See PMID 776530; uncharacterized protein 2244420 4978151 An01g09390 Aspergillus niger uncharacterized protein XP_001389359.1 2242430 R 5061 CDS An01g09400 4977774 join(2245402..2245676,2245745..2246063,2246124..2246870) II 1 NT_166518.1 Similarity: the ORF sequence shows some similarities to the A. oryzae EST SEQ ID NO:6333 rom patent WO200056762-A2.; Title: strong similarity to hypothetical protein CAD36997.1 - Neurospora crassa; uncharacterized protein 2246870 4977774 An01g09400 Aspergillus niger uncharacterized protein XP_001389360.1 2245402 D 5061 CDS An01g09410 4978175 complement(join(2248069..2248191,2248251..2248806,2248864..2248971,2249035..2249090,2249120..2249245)) II 1 NT_166518.1 Function: the zebrafish biklf gene encodes a novel Kruppel-like transcription factor.; Similarity: the predicted ORF shows similarity to some C2H2 zinc finger proteins.; Title: similarity to Kruppel-like transcription factor biklf - Danio rerio; See PMID 11025220; uncharacterized protein 2249245 4978175 An01g09410 Aspergillus niger uncharacterized protein XP_059603295.1 2248069 R 5061 CDS An01g09420 84590046 complement(join(2250563..2250739,2250867..2250974)) II 1 NT_166518.1 hypothetical protein 2250974 84590046 An01g09420 Aspergillus niger hypothetical protein XP_059603296.1 2250563 R 5061 CDS An01g09430 84590047 join(2251172..2251264,2251343..2251428,2251563..2251619,2251666..2251769,2251852..2251965,2252860..2252930,2253008..2253235,2253409..2253660,2253743..2253817,2253910..2254019,2254140..2254257,2254464..2254511) II 1 NT_166518.1 hypothetical protein 2254511 84590047 An01g09430 Aspergillus niger hypothetical protein XP_059603297.1 2251172 D 5061 CDS An01g09440 84590048 complement(join(2254620..2254688,2254780..2254927,2255046..2255135,2255221..2255372,2255489..2255556,2255808..2255935,2256277..2256393,2256482..2256552,2256604..2256683,2256776..2256974,2257055..2257159,2257235..2257244,2257304..2257473)) II 1 NT_166518.1 Similarity: shows only partial similarity to human COIL.; Title: weak similarity to coilin p80 COIL - Homo sapiens; uncharacterized protein 2257473 84590048 An01g09440 Aspergillus niger uncharacterized protein XP_059603298.1 2254620 R 5061 CDS An01g09450 4977703 complement(2259510..2260361) II 1 NT_166518.1 Similarity: shows only partial similarity to several hypothetical proteins.; Title: similarity to hypothetical protein SMa0322 -Sinorhizobium meliloti; uncharacterized protein 2260361 4977703 An01g09450 Aspergillus niger uncharacterized protein XP_059603299.1 2259510 R 5061 CDS An01g09460 4977303 complement(join(<2262875..2262898,2262955..2263460,2263517..2263815)) II 1 NT_166518.1 Function: WSC domain is a putative carbohydrate binding domain, the protein might be involved in carbohydrate utilization.; Remark: frameshift confirmed by cDNA comparison.; Remark: putative frameshift because of sequencing error.; Similarity: shows similarity to proteins with high content of repetitive sequences.; Title: similarity to glucoamylase III Wsc2 -Saccharomyces cerevisiae [putative frameshift]; putative frameshift; See PMID 3138030; uncharacterized protein 2263815 4977303 An01g09460 Aspergillus niger uncharacterized protein XP_059603300.1 2262875 R 5061 CDS An01g09470 84590049 join(2266387..2266416,2266518..2266775,2266864..2267048,2267104..2267155,2267208..2267471,2267557..2267799) II 1 NT_166518.1 hypothetical protein 2267799 84590049 An01g09470 Aspergillus niger hypothetical protein XP_059603301.1 2266387 D 5061 CDS An01g09480 4978033 complement(join(2269211..2269579,2269645..2269826,2269889..2269900,2269972..2270009,2270079..2270136,2270194..2270245)) II 1 NT_166518.1 Function: mutants of T. aestivum show altered the phospholipid composition of wild type yeast, with the most marked effect being increased abundance of phosphatidylserine.; Localization: might be localized in the ER or might be a mitochondrial protein.; Title: strong similarity to phosphatidylserine synthase pS232 - Triticum aestivum; uncharacterized protein 2270245 4978033 An01g09480 Aspergillus niger uncharacterized protein XP_001389368.3 2269211 R 5061 CDS An01g09490 4977441 complement(join(2270787..2271019,2271079..2271107,2271165..2271310,2271371..2271471,2271527..2271574,2271644..2271686)) II 1 NT_166518.1 Function: GAR1 of S. cerevisiae is involved in 35S rRNA processing and required for pre-rRNA processing.; Function: GAR1 of S. cerevisiae is involved in cleavage of 33S precursor rRNA at A1 site to yield 32S rRNA and in cleavage of 32S precursor rRNA at A2 site to yield 20S and 27SA2 precursors.; Function: GAR1 of S. cerevisiae is involved in pre-rRNA pseudouridylation.; Similarity: strong similarity to S. pombe GAR1 and fruit fly GCR101 protein.; Title: strong similarity to nucleolar rRNA processing protein Gar1 - Saccharomyces cerevisiae; nucleus; See PMID 1531632; See PMID 8502556; uncharacterized protein 2271686 4977441 An01g09490 Aspergillus niger uncharacterized protein XP_001389369.1 2270787 R 5061 CDS An01g09500 4977746 join(2271952..2272012,2272078..2272516,2272566..2272830,2272884..2273459,2273519..2274179,2274237..2274391) II 1 NT_166518.1 Catalytic activity: ATP + L-threonine + tRNA(THR) = AMP + pyrophosphate + L-threonyl-tRNA.; Similarity: strong similarity to members of class II aminoacyl-tRNA synthetases.; Title: strong similarity to cytosolic threonine--tRNA ligase Ths1 - Saccharomyces cerevisiae; cytoplasm; See PMID 2995918; uncharacterized protein 2274391 4977746 An01g09500 Aspergillus niger uncharacterized protein XP_001389370.1 2271952 D 5061 CDS An01g09510 4977771 join(2274988..2276397,2276453..2276504,2276566..2276810) II 1 NT_166518.1 Similarity: shows only partial similarity to sequence of DNA patent database.; Title: weak similarity to protein fragment SEQ ID NO:43781 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 2276810 4977771 An01g09510 Aspergillus niger uncharacterized protein XP_001389371.3 2274988 D 5061 CDS An01g09520 4977040 join(2277415..2277527,2277613..2277745,2277813..2277879,2277942..2278256,2278310..2278947) II 1 NT_166518.1 Function: MPKA of A. nidulans is involved in germination of conidial spores and polarized growth.; Function: MPKA of A. nidulans transfers phosphate from ATP to serine/threonine residues of the target protein.; Title: strong similarity to mitogen-activated protein kinase mPKA - Aspergillus nidulans; See PMID 10220889; uncharacterized protein 2278947 4977040 An01g09520 Aspergillus niger uncharacterized protein XP_001389372.1 2277415 D 5061 CDS An01g09530 4977101 complement(join(2279285..2279472,2279590..2279607,2279765..2279781,2279838..2280896,2280967..2281692,2281750..2281928)) II 1 NT_166518.1 Function: the C. nicotianae Crg1 is involved in cellular resistance to the perylenequinone toxin,cercosporin, that generates highly toxic singlet oxygen upon exposure to light.; Similarity: the A. niger protein, in contrast to CRG1 of C. nicotianae, contains a fungal-type Zn(2)-Cys(6) DNA-binding domain.; Title: similarity to cercosporin resistance protein CRG1 - Cercospora nicotianae; See PMID 12604346; uncharacterized protein 2281928 4977101 An01g09530 Aspergillus niger uncharacterized protein XP_059603302.1 2279285 R 5061 CDS An01g09540 4977161 join(2282186..2282795,2282874..2283067) II 1 NT_166518.1 Title: strong similarity to hypothetical short chain alcohol dehydrogenase SPCC663.06c - Schizosaccharomyces pombe; uncharacterized protein 2283067 4977161 An01g09540 Aspergillus niger uncharacterized protein XP_001389374.1 2282186 D 5061 CDS An01g09550 4977115 join(2284637..2284844,2284919..2285260,2285324..2285681,2285731..2286038,2286089..2286132) II 1 NT_166518.1 Title: similarity to hypothetical dihydrolipoamide dehydrogenase Rv2713 - Mycobacterium tuberculosis; uncharacterized protein 2286132 4977115 An01g09550 Aspergillus niger uncharacterized protein XP_001389375.1 2284637 D 5061 CDS An01g09560 4977023 complement(join(2286807..2287016,2287070..2287173,2287227..2287695,2287732..2287826,2287885..2288107)) II 1 NT_166518.1 Function: YLL057c of S. cerevisiae plays a role in sulfonate catabolism.; Title: strong similarity to Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase YLL057c -Saccharomyces cerevisiae; See PMID 10482536; uncharacterized protein 2288107 4977023 An01g09560 Aspergillus niger uncharacterized protein XP_059603303.1 2286807 R 5061 CDS An01g09570 4977444 join(2289344..2289589,2289652..2289747,2289811..2290095,2290178..2290303,2290358..2290453,2290500..2291025,2291092..2291330) II 1 NT_166518.1 Similarity: belongs to the major facilitator superfamily.; Title: strong similarity to hypothetical membrane protein YIL166c - Saccharomyces cerevisiae; uncharacterized protein 2291330 4977444 An01g09570 Aspergillus niger uncharacterized protein XP_001389377.1 2289344 D 5061 CDS An01g09580 4977093 complement(join(2291494..2292297,2292350..2292827,2292876..2293370,2293487..2293791)) II 1 NT_166518.1 Function: amyR of A. nidulans activates the expression of th gene encoding Taka-amylase A.; Induction: the expression of amyR of A. nidulans is under the control of the carbon catabolite repressor CREA.; Remark: an alternative name for amyR of A. nidulans is malA.; Title: strong similarity to transcription regulator of maltose utilization amyR - Aspergillus nidulans; nucleus; See PMID 11318101; uncharacterized protein 2293791 4977093 An01g09580 Aspergillus niger uncharacterized protein XP_059603304.1 2291494 R 5061 CDS An01g09590 4977843 join(2295204..2295271,2295333..2295355,2295411..2295565,2295620..2296174,2296225..2296449) II 1 NT_166518.1 Complex: Kv beta 1 of R. norvegicus is an accessory protein of the voltage-gated potassium channel Kv1.; Function: Kv beta 1 of R. norvegicus modulates the activity of the pore-forming alpha subunit of the voltage-gated potassium channel Kv1.; Title: strong similarity to voltage-gated potassium channel beta subunit Kv beta 1 - Rattus norvegicus; See PMID 9687064; See PMID 8183366; uncharacterized protein 2296449 4977843 An01g09590 Aspergillus niger uncharacterized protein XP_001389379.3 2295204 D 5061 CDS An01g09600 84590050 complement(join(2297467..2298111,2298209..2298509,2298573..2298934)) II 1 NT_166518.1 Remark: the C-terminus contains a highly acidic domain.; hypothetical protein 2298934 84590050 An01g09600 Aspergillus niger hypothetical protein XP_059603305.1 2297467 R 5061 CDS An01g09610 4978056 join(2300107..2300157,2300215..2300823) II 1 NT_166518.1 Remark: due to the presence of an GST domain, the ORF show similarity to glutathione S-transferases.; Similarity: shows strong similarity to a 5'-EST of the A. niger cDNA clone an_2396.; Similarity: shows strong similarity to the N-terminal half of translation elongation factor eEF-1 gamma chain.; Title: strong similarity to gamma subunit of translation elongation factor eEF-1 - Homo sapiens; uncharacterized protein 2300823 4978056 An01g09610 Aspergillus niger uncharacterized protein XP_001389381.1 2300107 D 5061 CDS An01g09620 4977107 complement(join(2301078..2301844,2301895..2303006,2303055..2303425)) II 1 NT_166518.1 Catalytic activity: RH2OH + O2 = RHO + H2O2.; Function: fao1 of C. cloacae catalyzes the flavin-dependent omega-oxidation using molecular oxygen as acceptor, producing hydrogen peroxid.; Pathway: fao1 of C. cloacae functions in the utilization of alkanes and long-chain fatty acids as carbon source.; Title: strong similarity to long-chain-fatty-acid alcohol oxidase fao1 - Candida cloacae; endoplasmatic reticulum; See PMID 10660617; uncharacterized protein 2303425 4977107 An01g09620 Aspergillus niger uncharacterized protein XP_001389382.1 2301078 R 5061 CDS An01g09630 4977192 join(2304880..2305024,2305081..2305203,2305258..2305326,2305381..2306405) II 1 NT_166518.1 Title: strong similarity to hypothetical protein YDR132c - Saccharomyces cerevisiae; uncharacterized protein 2306405 4977192 An01g09630 Aspergillus niger uncharacterized protein XP_001389383.1 2304880 D 5061 CDS An01g09640 4978223 complement(join(2306485..2308002,2308094..2308294)) II 1 NT_166518.1 Function: NOL1/NOP1/sun proteins are thought to be involved in rRNA/tRNA processing.; Similarity: belongs to the NOL1/NOP1/sun family of nucleolar proteins.; Title: strong similarity to hypothetical nucleolar protein SPAC2C4.06c - Schizosaccharomyces pombe; uncharacterized protein 2308294 4978223 An01g09640 Aspergillus niger uncharacterized protein XP_001389384.1 2306485 R 5061 CDS An01g09650 4977078 complement(join(2308994..2309419,2309623..2310069)) II 1 NT_166518.1 Title: weak similarity to FYVE domain-containing dual specificity protein phosphatase FYVE-DSP1b - Homo sapiens; uncharacterized protein 2310069 4977078 An01g09650 Aspergillus niger uncharacterized protein XP_001389385.1 2308994 R 5061 CDS An01g09660 84590051 join(2310282..2310389,2310932..2311013,2311329..2311507) II 1 NT_166518.1 hypothetical protein 2311507 84590051 An01g09660 Aspergillus niger hypothetical protein XP_059599714.1 2310282 D 5061 CDS An01g09670 84590052 complement(join(2311616..2311812,2311904..2311989,2312080..2312264,2312397..2312531,2312644..2312830,2312870..2313105,2313193..2313239,2313321..2313494,2313589..2313674,2313728..2313847,2313960..2314132,2314222..2314268,2314351..2314615,2314694..2314702)) II 1 NT_166518.1 hypothetical protein 2314702 84590052 An01g09670 Aspergillus niger hypothetical protein XP_059599715.1 2311616 R 5061 CDS An01g09680 84590053 join(2316407..2316415,2316504..2316602,2316660..2316723,2316807..2316813,2316873..2317079,2317150..2317258) II 1 NT_166518.1 hypothetical protein 2317258 84590053 An01g09680 Aspergillus niger hypothetical protein XP_059599716.1 2316407 D 5061 CDS An01g09690 84590054 join(2317290..2317393,2317580..2317654,2317693..2317853,2317944..2317996,2318050..2318103) II 1 NT_166518.1 hypothetical protein 2318103 84590054 An01g09690 Aspergillus niger hypothetical protein XP_059599717.1 2317290 D 5061 CDS An01g09700 84590055 complement(join(2318131..2318280,2318404..2318457,2318599..2318658,2319072..2319186,2319271..2319429,2319687..2319780,2319845..2319935)) II 1 NT_166518.1 Title: similarity to EST an_1026 - Aspergillus niger; uncharacterized protein 2319935 84590055 An01g09700 Aspergillus niger uncharacterized protein XP_059599718.1 2318131 R 5061 CDS An01g09710 84590056 join(2320229..2320280,2320358..2320417,2320475..2320567,2320655..2320755,2320849..2320900,2320990..2321033) II 1 NT_166518.1 hypothetical protein 2321033 84590056 An01g09710 Aspergillus niger hypothetical protein XP_059599719.1 2320229 D 5061 CDS An01g09720 84590057 complement(join(2321164..2321216,2321312..2321407,2321504..2321582)) II 1 NT_166518.1 hypothetical protein 2321582 84590057 An01g09720 Aspergillus niger hypothetical protein XP_059599720.1 2321164 R 5061 CDS An01g09730 4977106 join(2321824..2322027,2322126..2322172,2322228..2322307,2322358..2323610) II 1 NT_166518.1 Function: in A. niger GABA is used as a nitrogen source.; Induction: transcription of the gabA gene of A. nidulans is activated by the transcriptionfactor IntA.; Repression: transcription of the gabA gene of A. nidulans is repressed by the zinc finger transcription factor PacC.; Title: strong similarity to GABA permease gabA -Aspergillus nidulans; See PMID 10320578; uncharacterized protein 2323610 4977106 An01g09730 Aspergillus niger uncharacterized protein XP_001389393.1 2321824 D 5061 CDS An01g09740 4977504 complement(2323797..2325665) II 1 NT_166518.1 Catalytic activity: (S)-3-hydroxybutanoyl-CoA + NADP(+) = 3-acetoacetyl-CoA + NADPH.; Pathway: Beta-hydroxybutyryl-CoA dehydrogenase of C. acetobutylicum belongs to the butyrate/butanol-producing pathway.; Similarity: Beta-hydroxybutyryl-CoA dehydrogenase of C. acetobutylicum belongs to the 3-hydroxyacyl-CoA dehydrogenase family; Title: similarity to beta-hydroxybutyryl-CoA dehydrogenase hbd - Clostridium acetobutylicum; See PMID 8655474; uncharacterized protein 2325665 4977504 An01g09740 Aspergillus niger uncharacterized protein XP_001389394.1 2323797 R 5061 CDS An01g09750 4978413 complement(join(2326434..2327624,2327671..2327831,2327888..2327963)) II 1 NT_166518.1 Function: NADH-cytochrome b5 reductase is a component of a cytochrome b5-dependent electron transport system.; Function: NADH-cytochrome b5 reductase is involved in a variety of enzyme reactions these include fatty acyl coenzyme A desaturation or elongation, cholesterol biosynthesis, and certain cytochrome P-450-dependent oxidations.; Title: strong similarity to NADH-cytochrome b5 reductase - Mortierella alpina; See PMID 10473389; uncharacterized protein 2327963 4978413 An01g09750 Aspergillus niger uncharacterized protein XP_001389395.1 2326434 R 5061 CDS An01g09760 4978043 2328251..2329912 II 1 NT_166518.1 Function: cytochromes P450 are a group of heme-thiolate monooxygenases.; Similarity: human CYP4F2 belongs to the cytochrome P450 family.; Similarity: more than 250 N-terminal amino acids of the ORF are not included in the alignment with CYP4F2 of H. sapiens.; Title: strong similarity to cytochrome P450 4F2 CYP4F2 - Homo sapiens; See PMID 8026587; See PMID 10492403; uncharacterized protein 2329912 4978043 An01g09760 Aspergillus niger uncharacterized protein XP_001389396.1 2328251 D 5061 CDS An01g09770 4978291 complement(join(2329998..2330709,2330759..2330849,2330905..2330971,2331016..2331337,2331404..2331865,2331916..2332193,2332309..2332403,2332632..2332947,2333019..2333236,2333284..2333502,2333609..2333810)) II 1 NT_166518.1 Remark: the orf encoded protein shows homology to different types of protein kinases.; Title: similarity to mitogen-activated protein kinase ERK1 - Dictyostelium discoideum; See PMID 7935416; uncharacterized protein 2333810 4978291 An01g09770 Aspergillus niger uncharacterized protein XP_059599721.1 2329998 R 5061 CDS An01g09780 4978317 complement(2334240..>2335259) II 1 NT_166518.1 Catalytic activity: ldhA of E. coli catalyzes D-lactate + NAD(+) = pyruvate + NADH.; Function: ldhA of E. coli is a fermentative lactate dehydrogenase.; Remark: the ORF is N-terminally truncated due to contig border.; Similarity: ldhA of E. coli belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.; Title: strong similarity to D-lactate dehydrogenase ldhA - Escherichia coli [truncated ORF]; See PMID 9025293; uncharacterized protein 2335259 4978317 An01g09780 Aspergillus niger uncharacterized protein XP_001389398.1 2334240 R 5061 CDS An01g09790 84590058 complement(join(2335689..2335713,2336049..2336158)) II 1 NT_166518.1 Title: questionable ORF; uncharacterized protein 2336158 84590058 An01g09790 Aspergillus niger uncharacterized protein XP_059599722.1 2335689 R 5061 CDS An01g09800 4978384 join(2336508..2336613,2336694..2337544,2337594..2337905) II 1 NT_166518.1 Title: strong similarity to hypothetical protein encoded by ORF G4P06 - Aspergillus nidulans; uncharacterized protein 2337905 4978384 An01g09800 Aspergillus niger uncharacterized protein XP_001389400.1 2336508 D 5061 CDS An01g09810 4978281 complement(join(2338059..2339117,2339268..2339531)) II 1 NT_166518.1 Title: strong similarity to hypothetical alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase BH2688 - Bacillus halodurans; uncharacterized protein 2339531 4978281 An01g09810 Aspergillus niger uncharacterized protein XP_001389401.1 2338059 R 5061 CDS An01g09820 4978172 join(2340373..2340416,2340502..2340670,2340719..2340920,2340974..2342172) II 1 NT_166518.1 Catalytic activity: UDP glucose + 2 NAD+ + H2O = UDP glucuronate + 2 NADH.; Title: strong similarity to UDP-glucose dehydrogenase UDPGDH - Drosophila melanogaster; See PMID 9862465; uncharacterized protein 2342172 4978172 An01g09820 Aspergillus niger uncharacterized protein XP_059599723.1 2340373 D 5061 CDS An01g09830 4977447 complement(join(2342309..2342661,2342729..2343126,2343194..2343234)) II 1 NT_166518.1 Catalytic activity: RX + glutathione = HX + R-S-glutathione.; Title: strong similarity to glutathione S-transferase Gtt1 - Saccharomyces cerevisiae; See PMID 9792709; uncharacterized protein 2343234 4977447 An01g09830 Aspergillus niger uncharacterized protein XP_001389403.1 2342309 R 5061 CDS An01g09840 4977679 join(2343788..2343806,2343862..2343897,2344024..2344139,2344206..2344259) II 1 NT_166518.1 hypothetical protein 2344259 4977679 An01g09840 Aspergillus niger hypothetical protein XP_001389404.1 2343788 D 5061 CDS An01g09850 4977850 complement(2344530..2345354) II 1 NT_166518.1 Title: similarity to protein SEQ ID NO:2986 from patent WO200200677-A1 - Homo sapiens; uncharacterized protein 2345354 4977850 An01g09850 Aspergillus niger uncharacterized protein XP_001389405.1 2344530 R 5061 CDS An01g09860 4977258 join(2345702..2346600,2346653..2346845) II 1 NT_166518.1 Function: The hPrp18 protein of H. sapiens is required for the second step of mRNA splicing.; Title: strong similarity to pre-mRNA splicing factor hPrp18 - Homo sapiens; nucleus; uncharacterized protein 2346845 4977258 An01g09860 Aspergillus niger uncharacterized protein XP_001389406.1 2345702 D 5061 CDS An01g09870 4978181 join(2347427..2347563,2347624..2347802,2347947..2348176,2348247..2348585) II 1 NT_166518.1 Remark: Similarity to CaM II kinase of R. norvegicus is restricted to a single domain.; Similarity: the ORF is shorter than CaM II kinase of R. norvegicus (294 compared to 533 amino acids). Only 37 amino acids are included in the alignment between the two proteins.; Title: weak similarity to Ca2+/calmodulin-dependent protein kinase II delta chain - Rattus norvegicus; uncharacterized protein 2348585 4978181 An01g09870 Aspergillus niger uncharacterized protein XP_059599724.1 2347427 D 5061 CDS An01g09880 4977265 complement(join(2349006..2350564,2350659..2350719)) II 1 NT_166518.1 Title: similarity to hypothetical protein T41p -Homo sapiens; uncharacterized protein 2350719 4977265 An01g09880 Aspergillus niger uncharacterized protein XP_001389408.3 2349006 R 5061 CDS An01g09890 4977084 join(2351633..2351681,2351738..2352435) II 1 NT_166518.1 Function: ARL3 of S. cerevisiae is a non-essential protein that has a role in vesicular trafficking.; Remark: ARL3 of S. cerevisiae is also known as YPL051W.; Similarity: ARL3 of S. cerevisiae is a member of the highly conserved ADP-ribosylation factors (ARFs) family which are guanine nucleotide-binding proteins.; Title: strong similarity to ADP-ribosylation factor-like protein Arl3 - Saccharomyces cerevisiae; See PMID 9920936; uncharacterized protein 2352435 4977084 An01g09890 Aspergillus niger uncharacterized protein XP_001389409.1 2351633 D 5061 CDS An01g09900 4977501 join(2353193..2353288,2353347..2353868) II 1 NT_166518.1 Title: weak similarity to hypothetical protein Y2H9A.3 - Caenorhabditis elegans; uncharacterized protein 2353868 4977501 An01g09900 Aspergillus niger uncharacterized protein XP_001389410.1 2353193 D 5061 CDS An01g09910 4977291 complement(join(2354083..2354334,2354407..2355049,2355101..2355489,2355538..2355572,2355631..2355661)) II 1 NT_166518.1 Alternative name: GlcNAc-inositol phospholipid assembly protein, transcription factor SPT14.; Function: The S. cerevisiae SPT14 protein (SPT = Suppressor of Ty insertion mutations) was initially described as an activator of Ty transcription as well as regulator of several mating type genes including HIS4.; Remark: The S. cerevisiae SPT14 protein is similar to the H. sapiens PIG-A which is involved in transferring N-acetylglucosamine to lipopolysaccharides (biosynthesis of GPI anchors).; Title: strong similarity to GPI-anchor biosynthesis protein Pig-a - Saccharomyces cerevisiae; uncharacterized protein 2355661 4977291 An01g09910 Aspergillus niger uncharacterized protein XP_059599725.1 2354083 R 5061 CDS An01g09920 4977556 join(2356485..2357203,2357333..2357874,2358154..2358674) II 1 NT_166518.1 Remark: DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription,pre-mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.; Title: strong similarity to hypothetical DEAD box ATP-dependent RNA helicase SPCC285.03 - Schizosaccharomyces pombe; uncharacterized protein 2358674 4977556 An01g09920 Aspergillus niger uncharacterized protein XP_059599726.1 2356485 D 5061 CDS An01g09930 4977659 complement(join(2361415..2362505,2362577..2362913)) II 1 NT_166518.1 Function: required for propionate catabolism.; Title: strong similarity to propionate catabolic protein PrpD - Salmonella typhimurium; uncharacterized protein 2362913 4977659 An01g09930 Aspergillus niger uncharacterized protein XP_001389413.1 2361415 R 5061 CDS An01g09940 4977272 join(2363319..2363641,2363694..2363891,2363941..2364705,2364759..2364841,2364909..2364958) II 1 NT_166518.1 Catalytic activity: Citrate + CoA <=> acetyl-CoA + H(2)O + oxaloacetate.; Function: conversion of oxaloacetate to citrate in the glyoxylate cycle.; Title: strong similarity to glyoxysomal citrate synthase - Cucurbita sp.; See PMID 7888626; uncharacterized protein 2364958 4977272 An01g09940 Aspergillus niger uncharacterized protein XP_001389414.3 2363319 D 5061 CDS An01g09950 4977928 join(2366362..2366610,2366687..2367895) II 1 NT_166518.1 Remark: The A. terreus cds is included in the lovastatin biosynthesis gene cluster.; Title: strong similarity to hypothetical protein of the lovastatin biosynthesis gene cluster - Aspergillus terreus; See PMID 10334994; uncharacterized protein 2367895 4977928 An01g09950 Aspergillus niger uncharacterized protein XP_001389415.1 2366362 D 5061 CDS An01g09960 4977682 2368215..2370629 II 1 NT_166518.1 Catalytic activity: Hydrolysis of 1,4-beta-D-xylans so as to remove successive D-xylose residues from the non-reducing termini.; Gene-ID: xlnD;xylD; Mapping: xlnD from A. niger is mapped to chromosome II (LG II); see list from DSM, EMBL Z84377.; Remark: The xlnD xylosidase exhibits high activity on the artificial substrate p-nitrophenyl beta-D-xylopyranoside (XylNp) and a sideactivity on p-nitrophenyl alpha-L-arabinofuranoside and p-nitrophenyl beta-D-glucopyranoside.; See PMID 9128738; See PMID 9546179; xylosidase xlnD-Aspergillus niger 2370629 xlnD 4977682 xlnD Aspergillus niger xylosidase xlnD-Aspergillus niger XP_001389416.1 2368215 D 5061 CDS An01g09970 4977369 complement(join(2371149..2371462,2371534..2371600,2371661..2371744,2371801..2372011,2372202..2372450,2372503..2372584,2372649..2372782,2372841..2372936,2372972..2373118,2373196..2373242)) II 1 NT_166518.1 Title: weak similarity to Lactobacillus crispatus silent surface layer protein cbsB - Lactobacillus crispatus; See PMID 11053389; uncharacterized protein 2373242 4977369 An01g09970 Aspergillus niger uncharacterized protein XP_059599727.1 2371149 R 5061 CDS An01g09980 4977576 join(2374363..2374457,2374517..2374859) II 1 NT_166518.1 Title: strong similarity to hemolysin Asp-HS -Aspergillus fumigatus; See PMID 8086452; See PMID 8860955; See PMID 8913518; See PMID 16196; See PMID 778450; uncharacterized protein 2374859 4977576 An01g09980 Aspergillus niger uncharacterized protein XP_001389418.1 2374363 D 5061 CDS An01g10000 4977811 complement(join(2375652..2375757,2375827..2377498,2377547..2380170,2380230..2380333)) II 1 NT_166518.1 Title: strong similarity to ATP-binding cassette transporter abc1p - Schizosaccharomyces pombe; See PMID 9037770; uncharacterized protein 2380333 4977811 An01g10000 Aspergillus niger uncharacterized protein XP_001389419.1 2375652 R 5061 CDS An01g10010 4977191 join(2381748..2381767,2381829..2383479) II 1 NT_166518.1 Catalytic activity: O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate.; Function: The O-succinylhomoserine (thiol)-lyase met-7 chain of N. crassa is required to form O-succinylhomoserine (thiol)-lyase together with met-3 chain.; Remark: Can also use hydrogen sulfide and methanethiol as substrates producing homocysteine and methionine respectively.; Remark: In the absence of thiol, can also catalyse beta,gamma-elimination to form 2-oxobutanoate, succinate and ammonia.; Title: strong similarity to O-succinylhomoserine (thiol)-lyase met-7 chain - Neurospora crassa; uncharacterized protein 2383479 4977191 An01g10010 Aspergillus niger uncharacterized protein XP_001389420.3 2381748 D 5061 CDS An01g10020 84590059 join(2385021..2386442,2386578..2386606,2386645..2386669) II 1 NT_166518.1 hypothetical protein 2386669 84590059 An01g10020 Aspergillus niger hypothetical protein XP_059599728.1 2385021 D 5061 CDS An01g10030 4978475 complement(join(2386961..2387547,2387606..2387815,2387972..2388296)) II 1 NT_166518.1 Function: S. cerevisiae Syr2p is a sphingosine hydroxylase and provides resistance to the Pseudomonas syringae cyclic lipodepsipeptide syringomycin. Syr2p is required for the hydroxylation of C-4 of the sphingoid moiety of ceramid.; Remark: alternative gene names for the S. cerevisiae homolog SYR2 are SUR2 and YDR297w.; Title: strong similarity to syringomycin-resistance gene Syr2 - Saccharomyces cerevisiae; uncharacterized protein 2388296 4978475 An01g10030 Aspergillus niger uncharacterized protein XP_059599729.1 2386961 R 5061 CDS An01g10040 84590060 join(2388792..2388879,2389012..2389139) II 1 NT_166518.1 hypothetical protein 2389139 84590060 An01g10040 Aspergillus niger hypothetical protein XP_059599730.1 2388792 D 5061 CDS An01g10050 4978257 join(2389510..2389524,2389737..2390022,2390094..2390253,2390312..2390396) II 1 NT_166518.1 Remark: the immunoglobulin E (IgE)-dependent histamine-releasing factor (HRF) is produced by lymphocytes of atopic children.; Title: strong similarity to IgE-dependent histamine-releasing factor - Homo sapiens; uncharacterized protein 2390396 4978257 An01g10050 Aspergillus niger uncharacterized protein XP_001389424.1 2389510 D 5061 CDS An01g10060 4978221 complement(join(2390899..2392114,2392168..2392238,2392289..2392605,2392659..2393691,2393746..2393785,2393836..2394365,2394422..2394634)) II 1 NT_166518.1 Title: strong similarity to hypothetical transcription activator SPAC139.03 - Schizosaccharomyces pombe; uncharacterized protein 2394634 4978221 An01g10060 Aspergillus niger uncharacterized protein XP_001389425.1 2390899 R 5061 CDS An01g10070 4977133 complement(join(2395286..2395662,2395758..2396184)) II 1 NT_166518.1 Function: a S. cerevisiae mutant sec65-1 is conditionally defective in the insertion of integral membrane proteins into the ER.; Remark: the S. cerevisiae SEC65 gene encodes a 32 kDa subunit of yeast signal recognition particle (SRP).; Title: strong similarity to signal recognition particle chain Sec65 - Saccharomyces cerevisiae; See PMID 9723915; uncharacterized protein 2396184 4977133 An01g10070 Aspergillus niger uncharacterized protein XP_001389426.1 2395286 R 5061 CDS An01g10080 84590061 complement(join(2397124..2397316,2397417..2397481,2397588..2397653)) II 1 NT_166518.1 hypothetical protein 2397653 84590061 An01g10080 Aspergillus niger hypothetical protein XP_059599731.1 2397124 R 5061 CDS An01g10090 84590062 join(2398353..2398430,2398675..2398793,2399255..2399377,2399813..2399966) II 1 NT_166518.1 hypothetical protein 2399966 84590062 An01g10090 Aspergillus niger hypothetical protein XP_059599732.1 2398353 D 5061 CDS An01g10100 4977725 join(2400277..2400289,2400349..2400654,2400712..2401058,2401158..2401610,2401704..2401961) II 1 NT_166518.1 Similarity: strong similarity to superfamily of aminotransferases/transaminases.; Title: strong similarity to hypothetical aminotransferase SPBC1773.03c - Schizosaccharomyces pombe; uncharacterized protein 2401961 4977725 An01g10100 Aspergillus niger uncharacterized protein XP_001389429.1 2400277 D 5061 CDS An01g10110 84590063 join(2402725..2402751,2402996..2403430,2403499..2403585) II 1 NT_166518.1 hypothetical protein 2403585 84590063 An01g10110 Aspergillus niger hypothetical protein XP_059599733.1 2402725 D 5061 CDS An01g10120 84590064 join(2404837..2404847,2405088..2405184,2405253..2405438) II 1 NT_166518.1 hypothetical protein 2405438 84590064 An01g10120 Aspergillus niger hypothetical protein XP_059599734.1 2404837 D 5061 CDS An01g10130 84590065 join(2405972..2405979,2406034..2406247,2406314..2406499) II 1 NT_166518.1 Title: similarity to hypothetical protein encoded by An14g05700 - Aspergillus niger; uncharacterized protein 2406499 84590065 An01g10130 Aspergillus niger uncharacterized protein XP_059599735.1 2405972 D 5061 CDS An01g10140 4977256 complement(join(2406598..2407163,2407228..2407888,2407947..2409093,2409437..2409534,2409592..2409744)) II 1 NT_166518.1 Function: YSH1 is involved in cleavage of pre-mRNA during 3'-end formation in yeast.; Remark: BRR5 is an alternative name for YSH1.; Title: similarity to component of pre-mRNA polyadenylation factor PF I Ysh1 - Saccharomyces cerevisiae; nucleus; See PMID 9099738; uncharacterized protein 2409744 4977256 An01g10140 Aspergillus niger uncharacterized protein XP_001389433.1 2406598 R 5061 CDS An01g10150 4977302 join(2410485..2411565,2411621..2412267) II 1 NT_166518.1 Title: similarity to hypothetical protein CAD21098.1 - Neurospora crassa; uncharacterized protein 2412267 4977302 An01g10150 Aspergillus niger uncharacterized protein XP_001389434.1 2410485 D 5061 CDS An01g10160 84590066 complement(join(2413858..2413922,2414006..2414346,2414467..2414573,2414740..2414835)) II 1 NT_166518.1 hypothetical protein 2414835 84590066 An01g10160 Aspergillus niger hypothetical protein XP_059599736.1 2413858 R 5061 CDS An01g10170 4977105 join(2415317..2416180,2416244..2416322,2416377..2416724,2416780..2417242,2417291..2417378,2417438..2417635) II 1 NT_166518.1 Function: PK12 protein autophosphorylates in vitro on serine, threonine, and tyrosine residues, thereby making it a member of the dual-specificity protein kinases.; Similarity: protein kinase PK12 belong to the LAMMER family; Title: similarity to protein kinase PK12 - Nicotiana tabacum; See PMID 8989879; uncharacterized protein 2417635 4977105 An01g10170 Aspergillus niger uncharacterized protein XP_001389436.1 2415317 D 5061 CDS An01g10180 84590067 complement(join(2417757..2418188,2418243..2418257)) II 1 NT_166518.1 hypothetical protein 2418257 84590067 An01g10180 Aspergillus niger hypothetical protein XP_059599737.1 2417757 R 5061 CDS An01g10190 4978004 complement(join(2419970..2420650,2420722..2420816,2420882..2421015,2421078..2421280)) II 1 NT_166518.1 Function: mitochondrial tricarboxylate carrier shows citrate transport activity.; Remark: the ORF encoded protein also shows similarity to sideroflexin 1 from M. musculus. Disruption of this mitochondrial protein leads to pathologic intramitochondrial iron deposits in erythrocytes.; Title: similarity to mitochondrial tricarboxylate carrier - Rattus sp.; localisation:mitochondrion; See PMID 6617879; See PMID 8132491; uncharacterized protein 2421280 4978004 An01g10190 Aspergillus niger uncharacterized protein XP_001389438.3 2419970 R 5061 CDS An01g10200 4977331 complement(join(2421885..2421942,2421983..2422048,2422102..2424215)) II 1 NT_166518.1 Remark: most blastp matches are due to repetitive amino acids. In the other ones the match is restricted to the PDH Domain.; Title: weak similarity to hypothetical protein CG9007 - Drosophila melanogaster; uncharacterized protein 2424215 4977331 An01g10200 Aspergillus niger uncharacterized protein XP_059599738.1 2421885 R 5061 CDS An01g10210 84590068 complement(join(2425348..2425439,2425544..2425640,2426003..2426194)) II 1 NT_166518.1 hypothetical protein 2426194 84590068 An01g10210 Aspergillus niger hypothetical protein XP_059599739.1 2425348 R 5061 CDS An01g10220 84590069 join(2426311..2426370,2426436..2426498,2426579..2426691,2426778..2427047,2427269..2427292,2427384..2427507) II 1 NT_166518.1 hypothetical protein 2427507 84590069 An01g10220 Aspergillus niger hypothetical protein XP_059599740.1 2426311 D 5061 CDS An01g10230 84590070 complement(join(2427780..2427956,2428127..2428233,2428329..2428409,2428484..2428594,2428921..2428947,2429027..2429087)) II 1 NT_166518.1 hypothetical protein 2429087 84590070 An01g10230 Aspergillus niger hypothetical protein XP_059599741.1 2427780 R 5061 CDS An01g10240 4977842 join(2429509..2429757,2429946..2430068,2430139..2430600) II 1 NT_166518.1 Title: similarity to hypothetical protein Rv2802c -Mycobacterium tuberculosis; uncharacterized protein 2430600 4977842 An01g10240 Aspergillus niger uncharacterized protein XP_001389443.1 2429509 D 5061 CDS An01g10250 84590071 complement(join(2430842..2430873,2431117..2431621)) II 1 NT_166518.1 hypothetical protein 2431621 84590071 An01g10250 Aspergillus niger hypothetical protein XP_059599742.1 2430842 R 5061 CDS An01g10270 4977687 join(2433385..2433599,2433658..2435656) II 1 NT_166518.1 Title: similarity to hypothetical protein YOR243c -Saccharomyces cerevisiae; uncharacterized protein 2435656 4977687 An01g10270 Aspergillus niger uncharacterized protein XP_001389445.1 2433385 D 5061 CDS An01g10280 84590072 2436324..2437958 II 1 NT_166518.1 Title: weak similarity to transcriptional activator protein ACEII from patent WO9823642-A1 - Trichoderma reesei; nucleus; uncharacterized protein 2437958 84590072 An01g10280 Aspergillus niger uncharacterized protein XP_059599743.1 2436324 D 5061 CDS An01g10290 4977278 complement(join(2438366..2439220,2439282..2439422,2439486..2439749)) II 1 NT_166518.1 Remark: the ORF encoded protein shows similarity to several hypothetical and known (patented) oxidoreductases.; Title: similarity to protein fragment SEQ ID NO:11998 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 2439749 4977278 An01g10290 Aspergillus niger uncharacterized protein XP_059599744.1 2438366 R 5061 CDS An01g10300 84590073 complement(join(2440496..2440631,2440709..2440794,2441180..2441311)) II 1 NT_166518.1 hypothetical protein 2441311 84590073 An01g10300 Aspergillus niger hypothetical protein XP_059599745.1 2440496 R 5061 CDS An01g10310 4977718 complement(join(2442464..2443594,2443660..2443764,2444027..2444084,2444115..2444188)) II 1 NT_166518.1 Remark: blastp matches are due to repetitive amino acids.; hypothetical protein 2444188 4977718 An01g10310 Aspergillus niger hypothetical protein XP_059599746.1 2442464 R 5061 CDS An01g10320 4977390 2445188..2446135 II 1 NT_166518.1 Remark: blastp matches are unspecific.; hypothetical protein 2446135 4977390 An01g10320 Aspergillus niger hypothetical protein XP_001389450.1 2445188 D 5061 CDS An01g10330 84590074 complement(join(2446620..2446859,2446999..2447115,2447284..2447414,2447493..2447699,2447747..2448014)) II 1 NT_166518.1 hypothetical protein 2448014 84590074 An01g10330 Aspergillus niger hypothetical protein XP_059599747.1 2446620 R 5061 CDS An01g10340 4977860 join(2448109..2448900,2448966..2449805) II 1 NT_166518.1 Phenotype: yeast sur4 mutants have altered bud localization.; Phenotype: yeast sur4 mutants have altered phospholipid composition.; Remark: ELO3, SRE1 and VBM1 are alternative names for SUR4.; Title: similarity to hypothetical fatty acid elongation protein Sur4 - Saccharomyces cerevisiae; See PMID 9211877; See PMID 9832547; uncharacterized protein 2449805 4977860 An01g10340 Aspergillus niger uncharacterized protein XP_001389452.1 2448109 D 5061 CDS An01g10350 4977214 join(2451312..2452123,2452184..2453163,2453217..2453513,2453569..2453640,2453700..2453787,2453844..2454639) II 1 NT_166518.1 Catalytic activity: beta-galactosidases hydrolyse terminal, non-reducing beta-D-galactose residues in beta-D-galactosides.; Function: A. niger lacA is involved in carbohydrate utilisation.; Title: strong similarity to secreted beta-galactosidase lacA - Aspergillus niger; See PMID 1368193; uncharacterized protein 2454639 4977214 An01g10350 Aspergillus niger uncharacterized protein XP_059599748.1 2451312 D 5061 CDS An01g10360 4977969 complement(join(2455091..2455263,2455325..2455772,2455824..2456055,2456113..2456273,2456342..2456505,2456555..2456657,2456723..2456977)) II 1 NT_166518.1 Function: TNA1 is necessary for nicotinic acid import into the cell.; Remark: YGR260w is the systematic name for TNA1 of S. cerevisiae.; Similarity: TNA1 belongs to the yeast Dal5p subfamily of the major facilitator family.; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563; uncharacterized protein 2456977 4977969 An01g10360 Aspergillus niger uncharacterized protein XP_001389454.1 2455091 R 5061 CDS An01g10370 84590075 join(2457011..2457110,2457252..2457623,2457827..2457911,2457962..2458198,2458301..2458377,2459192..2459340) II 1 NT_166518.1 Title: weak similarity to hypothetical protein D1044.3 - Caenorhabditis elegans; uncharacterized protein 2459340 84590075 An01g10370 Aspergillus niger uncharacterized protein XP_059599749.1 2457011 D 5061 CDS An01g10380 4978035 complement(join(2460244..2460659,2460725..2462588)) II 1 NT_166518.1 Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: weak similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942; uncharacterized protein 2462588 4978035 An01g10380 Aspergillus niger uncharacterized protein XP_001389456.3 2460244 R 5061 CDS An01g10390 84590076 join(2463032..2463154,2463352..2463450,2463527..2463616) II 1 NT_166518.1 hypothetical protein 2463616 84590076 An01g10390 Aspergillus niger hypothetical protein XP_059599750.1 2463032 D 5061 CDS An01g10400 84590077 complement(join(2464372..2464563,2464618..2464715,2464972..2465057,2465152..2465282,2465500..2465727)) II 1 NT_166518.1 hypothetical protein 2465727 84590077 An01g10400 Aspergillus niger hypothetical protein XP_059599751.1 2464372 R 5061 CDS An01g10410 84590078 join(2466535..2466618,2466682..2466756) II 1 NT_166518.1 hypothetical protein 2466756 84590078 An01g10410 Aspergillus niger hypothetical protein XP_059599752.1 2466535 D 5061 CDS An01g10420 84590079 complement(join(2468141..2468363,2468427..2468494)) II 1 NT_166518.1 hypothetical protein 2468494 84590079 An01g10420 Aspergillus niger hypothetical protein XP_059599753.1 2468141 R 5061 CDS An01g10430 84590080 join(2469261..2469266,2469337..2469423) II 1 NT_166518.1 hypothetical protein 2469423 84590080 An01g10430 Aspergillus niger hypothetical protein XP_059599754.1 2469261 D 5061 CDS An01g10440 84590081 complement(join(2469947..2469999,2470240..2470296,2470690..2470735)) II 1 NT_166518.1 hypothetical protein 2470735 84590081 An01g10440 Aspergillus niger hypothetical protein XP_059599755.1 2469947 R 5061 CDS An01g10450 84590082 join(2471742..2471905,2472099..2472795,2472832..2472921,2472973..2473794) II 1 NT_166518.1 Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: weak similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942; uncharacterized protein 2473794 84590082 An01g10450 Aspergillus niger uncharacterized protein XP_059599756.1 2471742 D 5061 CDS An01g10460 4978077 join(2474288..2474454,2474518..2475364,2475426..2476046) II 1 NT_166518.1 Title: similarity to hypothetical protein CAD21056.1 - Neurospora crassa; uncharacterized protein 2476046 4978077 An01g10460 Aspergillus niger uncharacterized protein XP_001389464.3 2474288 D 5061 CDS An01g10470 4977555 join(2476520..2476522,2476698..2477591) II 1 NT_166518.1 Title: similarity to hypothetical protein encoded by An01g09070 - Aspergillus niger; uncharacterized protein 2477591 4977555 An01g10470 Aspergillus niger uncharacterized protein XP_059599757.1 2476520 D 5061 CDS An01g10480 84590083 2478514..2478927 II 1 NT_166518.1 Title: strong similarity to FLO11 gene expression regulator At03 from patent WO200257456-A2 - Unclassified organism; uncharacterized protein 2478927 84590083 An01g10480 Aspergillus niger uncharacterized protein XP_059599758.1 2478514 D 5061 CDS An01g10490 4977121 2480108..2481592 II 1 NT_166518.1 Function: RIPA is a novel Ras-interacting protein from Dictyostelium, whose function is required for both chemotaxis and the synthesis and relay of the cyclic AMP (cAMP) chemoattractant signal.; Remark: similarity to RIPA is mainly due to Q-rich regions.; Title: similarity to Ras-interacting protein RIPA -Dictyostelium discoideum; See PMID 10473630; uncharacterized protein 2481592 4977121 An01g10490 Aspergillus niger uncharacterized protein XP_059599759.1 2480108 D 5061 CDS An01g10500 84590084 complement(join(2482204..2482331,2482418..2482467,2482534..2482718)) II 1 NT_166518.1 hypothetical protein 2482718 84590084 An01g10500 Aspergillus niger hypothetical protein XP_059599760.1 2482204 R 5061 CDS An01g10510 84590085 join(2483477..2483527,2484084..2484159,2484238..2484278,2484379..2484495,2484613..2484674,2484774..2484808,2485089..2485326,2485412..2485539,2485696..2485853,2485953..2486069,2486758..2486871,2487226..2487274,2487441..2487541,2487631..2487689,2487857..2488051,2488125..2488174,2488369..2488410,2488511..2488576,2488687..2488952) II 1 NT_166518.1 hypothetical protein 2488952 84590085 An01g10510 Aspergillus niger hypothetical protein XP_059599761.1 2483477 D 5061 CDS An01g10520 84590086 complement(join(2489015..2489089,2489263..2489409,2489521..2489578,2489660..2489788,2489837..2489930,2490177..2490309,2490554..2490628)) II 1 NT_166518.1 hypothetical protein 2490628 84590086 An01g10520 Aspergillus niger hypothetical protein XP_059599762.1 2489015 R 5061 CDS An01g10530 84590087 join(2491315..2491394,2491517..2491606,2491702..2491831,2491906..2492031) II 1 NT_166518.1 hypothetical protein 2492031 84590087 An01g10530 Aspergillus niger hypothetical protein XP_059599763.1 2491315 D 5061 CDS An01g10540 4978338 2494442..2495719 II 1 NT_166518.1 Function: the A. nidulans brlA gene is a primary regulator of development-specific gene expression during conidiation.; Remark: mutations in brlA, that disrupt either or both Cys2-His2 Zn(II) coordination sites, result in brlA alleles that fail to induce either the asexual reproductive pathway or the expression of development-specific genes.; Title: strong similarity to developmental regulatory protein brlA - Aspergillus nidulans; See PMID 2108321; See PMID 3293800; See PMID 9073485; uncharacterized protein 2495719 4978338 An01g10540 Aspergillus niger uncharacterized protein XP_001389472.3 2494442 D 5061 CDS An01g10550 4977760 join(2496886..2497147,2497255..2497949) II 1 NT_166518.1 Similarity: The transposase Minos-2 from Drosophila hydei is a member of the Tc1-like family of transposons.; Title: strong similarity to transposase Minos-2 -Drosophila hydei; See PMID 8197129; See PMID 1661410; uncharacterized protein 2497949 4977760 An01g10550 Aspergillus niger uncharacterized protein XP_059599764.1 2496886 D 5061 CDS An01g10560 84590088 join(2498366..2498400,2498549..2498588,2498693..2498702,2498962..2499052,2499086..2499266,2499432..2499607,2500114..2500200,2500249..2500384) II 1 NT_166518.1 hypothetical protein 2500384 84590088 An01g10560 Aspergillus niger hypothetical protein XP_059599765.1 2498366 D 5061 CDS An01g10570 4977026 complement(join(2500845..2500914,2500947..2501099,2501776..2502074)) II 1 NT_166518.1 Title: similarity to hypothetical protein EAA65998.1 - Aspergillus nidulans; uncharacterized protein 2502074 4977026 An01g10570 Aspergillus niger uncharacterized protein XP_001389475.3 2500845 R 5061 CDS An01g10580 4977729 join(2503590..2503819,2503871..2504055,2504105..2504220,2504268..2504463,2504515..2504579) II 1 NT_166518.1 Catalytic activity: Two-stage endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates.; Title: strong similarity to ribonuclease T2 precursor rntB - Aspergillus oryzae; See PMID 1913876; See PMID 3169020; uncharacterized protein 2504579 4977729 An01g10580 Aspergillus niger uncharacterized protein XP_001389476.1 2503590 D 5061 CDS An01g10590 84590089 complement(join(2507896..2507979,2508011..2508124)) II 1 NT_166518.1 hypothetical protein 2508124 84590089 An01g10590 Aspergillus niger hypothetical protein XP_059599766.1 2507896 R 5061 CDS An01g10600 4977381 complement(join(2509598..2510300,2510369..2510487)) II 1 NT_166518.1 Title: strong similarity to hypothetical protein F2P05 - Aspergillus nidulans; uncharacterized protein 2510487 4977381 An01g10600 Aspergillus niger uncharacterized protein XP_001389478.3 2509598 R 5061 CDS An01g10610 4977938 join(2511219..2511318,2511396..2511827,2511880..2511977,2512031..2512105,2512162..2512413) II 1 NT_166518.1 Remark: D-arabinitol dehydrogenase from patent JP11332569-A is used as a clinical diagnosing agent for mycosis.; Title: similarity to D-arabinitol dehydrogenase from patent JP11332569-A - Bacillus sp.; uncharacterized protein 2512413 4977938 An01g10610 Aspergillus niger uncharacterized protein XP_001389479.1 2511219 D 5061 CDS An01g10620 4977388 complement(join(2512575..2513063,2513121..2513453)) II 1 NT_166518.1 hypothetical protein 2513453 4977388 An01g10620 Aspergillus niger hypothetical protein XP_001389480.1 2512575 R 5061 CDS An01g10630 84590090 complement(join(2513786..2513922,2514133..2514330,2514553..2514615,2514769..2514896,2515099..2515505)) II 1 NT_166518.1 hypothetical protein 2515505 84590090 An01g10630 Aspergillus niger hypothetical protein XP_059599767.1 2513786 R 5061 CDS An01g10640 4977816 2515866..2516981 II 1 NT_166518.1 Title: strong similarity to hypothetical exported protein YPO0987 - Yersinia pestis; uncharacterized protein 2516981 4977816 An01g10640 Aspergillus niger uncharacterized protein XP_001389482.1 2515866 D 5061 CDS An01g10650 4977793 join(2517791..2517845,2517944..2518023,2518135..2518588,2518639..2519120) II 1 NT_166518.1 Catalytic activity: (S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate.; Induction: By N-carbamoyl-L-aspartate.; Pathway: URA4 catalyzes third step in pyrimidine biosynthesis pathway.; Similarity: URA4 belongs to the DHOase family.; Title: strong similarity to dihydroorotase Ura4 -Saccharomyces cerevisiae; See PMID 2897615; uncharacterized protein 2519120 4977793 An01g10650 Aspergillus niger uncharacterized protein XP_001389483.1 2517791 D 5061 CDS An01g10660 4977712 complement(join(2519199..2519801,2519867..2520183,2520248..2520305)) II 1 NT_166518.1 Title: similarity to hypothetical protein G4P04 -Aspergillus nidulans; uncharacterized protein 2520305 4977712 An01g10660 Aspergillus niger uncharacterized protein XP_059599768.1 2519199 R 5061 CDS An01g10680 10098240 join(2521266..2521464,2521514..2521571,2522114..2522591,2522732..2523209,2523598..2523747,2523798..2523856,2523917..2524348) II 1 NT_166518.1 Title: similarity to hypothetical developmental regulatory protein brlA - Aspergillus nidulans; uncharacterized protein 2524348 10098240 An01g10680 Aspergillus niger uncharacterized protein XP_003188541.2 2521266 D 5061 CDS An01g10690 4977662 join(2524814..2525416,2525495..2525542) II 1 NT_166518.1 Title: weak similarity to secreted protein SEQ ID NO: 305 from patent WO200142451-A2 - Homo sapiens; uncharacterized protein 2525542 4977662 An01g10690 Aspergillus niger uncharacterized protein XP_001389486.1 2524814 D 5061 CDS An01g10700 4977327 complement(join(2525814..2526374,2526552..2527118,2527170..2527274,2527326..2527493)) II 1 NT_166518.1 Title: strong similarity to hypothetical protein SPBC36B7.04 - Schizosaccharomyces pombe; uncharacterized protein 2527493 4977327 An01g10700 Aspergillus niger uncharacterized protein XP_059599769.1 2525814 R 5061 CDS An01g10710 84590091 join(2528142..2528163,2528216..2529045,2529134..2529701,2529891..2530093) II 1 NT_166518.1 Title: strong similarity to hypothetical protein DD57 - Mus musculus; uncharacterized protein 2530093 84590091 An01g10710 Aspergillus niger uncharacterized protein XP_059599770.1 2528142 D 5061 CDS An01g10720 4977702 join(2530201..2530203,2530276..2530309,2530573..2530782,2530853..2530875) II 1 NT_166518.1 Function: RPS31 is a structural protein of the small ribosomal (40S)-subunit.; Pathway: RPS31 is involved in protein biosynthesis.; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit Rps31 - Saccharomyces cerevisiae; cytoplasm; See PMID 9830035; 40S ribosomal protein eS25 2530875 4977702 An01g10720 Aspergillus niger 40S ribosomal protein eS25 XP_001389489.1 2530201 D 5061 CDS An01g10730 4978229 complement(join(2531296..2531816,2532004..2532124)) II 1 NT_166518.1 Title: similarity to plasma membrane bound receptor from patent DE19627237-A1 - Sus scrofa; uncharacterized protein 2532124 4978229 An01g10730 Aspergillus niger uncharacterized protein XP_059599771.1 2531296 R 5061 CDS An01g10740 4977894 complement(join(2533375..2533534,2533582..2534265,2534317..2534418,2534472..2534680)) II 1 NT_166518.1 Title: strong similarity to hypothetical Ras-like GTP-binding protein RagC - Homo sapiens; uncharacterized protein 2534680 4977894 An01g10740 Aspergillus niger uncharacterized protein XP_001389491.3 2533375 R 5061 CDS An01g10750 4977720 join(2536412..2536421,2536532..2536862,2536927..2536939,2537001..2537035,2537086..2537101,2537171..2537337,2537392..2537726,2537824..2538728) II 1 NT_166518.1 Title: strong similarity to hypothetical acid phosphatase CAB58405.1 - Schizosaccharomyces pombe; uncharacterized protein 2538728 4977720 An01g10750 Aspergillus niger uncharacterized protein XP_059599772.1 2536412 D 5061 CDS An01g10760 84590092 complement(join(2538937..2538988,2539069..2541391,2541809..2542265)) II 1 NT_166518.1 Title: strong similarity to hypothetical protein YKR079c - Saccharomyces cerevisiae; uncharacterized protein 2542265 84590092 An01g10760 Aspergillus niger uncharacterized protein XP_059599773.1 2538937 R 5061 CDS An01g10770 4977940 complement(join(2543337..2544181,2544244..2545243)) II 1 NT_166518.1 Title: weak similarity to DNA-binding protein Mcm1 -Saccharomyces cerevisiae; uncharacterized protein 2545243 4977940 An01g10770 Aspergillus niger uncharacterized protein XP_001389494.1 2543337 R 5061 CDS An01g10780 84590093 join(2547722..2547860,2548189..2548387,2548529..2548577) II 1 NT_166518.1 hypothetical protein 2548577 84590093 An01g10780 Aspergillus niger hypothetical protein XP_059599774.1 2547722 D 5061 CDS An01g10790 4977255 complement(join(2548969..2549106,2549182..2549307)) II 1 NT_166518.1 Title: strong similarity to hypothetical conidiation-specific protein con-10 - Neurospora crassa; uncharacterized protein 2549307 4977255 An01g10790 Aspergillus niger uncharacterized protein XP_001389496.1 2548969 R 5061 CDS An01g10800 4977880 complement(2550429..2551472) II 1 NT_166518.1 Function: ERG25 catalyses the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol.; Localization: Immunofluorescence data suggest that ERG25 is present in the endoplasmic reticulum and plasma membrane.; Pathway: Ergosterol biosynthesis.; Similarity: ERG25 belongs to the sterol desaturase family.; Similarity: The amino acid sequence of ERG25 shows a C-terminal endoplasmic reticulum retrieval signal KKXX and three histidine-rich clusters found in eukaryotic membrane desaturases.; Title: similarity to methyl sterol oxidase Erg25 -Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 8552601; See PMID 8663358; uncharacterized protein 2551472 4977880 An01g10800 Aspergillus niger uncharacterized protein XP_001389497.1 2550429 R 5061 CDS An01g10810 4977505 join(2551772..2551850,2551900..2552065,2552178..2552303,2552477..2552599,2552668..2552768,2552855..2552916,2552995..2553069,2553188..2553248,2553345..2553437,2553787..2553911,2554209..2554400,2554452..2555308,2555362..2555527,2555583..2555751,2555814..2555925,2556092..2556662) II 1 NT_166518.1 Remark: TRK1 is also involved in the control of the membrane potential.; Remark: The TRK1 potassium transporters of the soil yeast Schwanniomyces occidentalis is operating at low and medium K+ concentrations (< 1 mM); it functions at neutral and high pH and fails at low pH.; Title: strong similarity to high-affinity potassium uptake transporter trk1 - Schwanniomyces occidentalis; See PMID 10931360; uncharacterized protein 2556662 4977505 An01g10810 Aspergillus niger uncharacterized protein XP_059599775.1 2551772 D 5061 CDS An01g10820 4977690 complement(join(2557101..2559140,2559180..2559473)) II 1 NT_166518.1 Title: strong similarity to hypothetical membrane protein YOR206w - Saccharomyces cerevisiae; uncharacterized protein 2559473 4977690 An01g10820 Aspergillus niger uncharacterized protein XP_059599776.1 2557101 R 5061 CDS An01g10830 4977616 join(2559801..2559805,2559882..2560098,2560164..2560568) II 1 NT_166518.1 Title: strong similarity to hypothetical protein YPL065w - Saccharomyces cerevisiae; uncharacterized protein 2560568 4977616 An01g10830 Aspergillus niger uncharacterized protein XP_059599777.1 2559801 D 5061 CDS An01g10840 4978497 join(2560942..2560975,2561044..2561304,2561395..2562161) II 1 NT_166518.1 Title: strong similarity to hypothetical membrane protein YBR271w - Saccharomyces cerevisiae; uncharacterized protein 2562161 4978497 An01g10840 Aspergillus niger uncharacterized protein XP_001389501.1 2560942 D 5061 CDS An01g10850 4977268 complement(join(2562702..2563594,2563644..2564951,2564984..2565067,2565113..2565131)) II 1 NT_166518.1 Function: S. cerevisiae Msp1 is involved in intramitochondrial sorting of proteins.; Localization: S. cerevisiae Msp1 is an integral membrane protein in the mitochondrial outer membrane.; Remark: alternate names for S. cerevisiae Msp1: Yta4 or YGR028W.; Similarity: S. cerevisiae Msp1 belongs to the AAA family of ATPases.; Title: similarity to membrane-spanning ATPase Msp1 -Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 7754704; See PMID 8226973; uncharacterized protein 2565131 4977268 An01g10850 Aspergillus niger uncharacterized protein XP_059599778.1 2562702 R 5061 CDS An01g10860 4977783 join(2566304..2566504,2566600..2566954,2566996..2567024) II 1 NT_166518.1 Title: similarity to hypothetical protein encoded by An04g08050 - Aspergillus niger; uncharacterized protein 2567024 4977783 An01g10860 Aspergillus niger uncharacterized protein XP_059599779.1 2566304 D 5061 CDS An01g10870 4977763 complement(join(2567143..2568308,2568405..2569332)) II 1 NT_166518.1 Function: C. albicans CHR1/S. cerevisiae Rok1 are involved in ribosome biogenesis. More specifically in a early step of the processing of the 35S rRNA precursor.; Remark: C. albicans CHR1 was cloned by functional complementation of the S. cerevisiae rok1 mutation. Literture for S. cerevisiae Rok1: Pubmed 9154839; 9848659; 9571634.; Similarity: the ORF encoded protein and the C. albicans CHR1 helicase are homologs of the well characterized Rok1 helicase from S. cerevisiae.; Title: strong similarity to DEAD box RNA helicase CHR1 - Candida albicans; nucleus; See PMID 10705369; uncharacterized protein 2569332 4977763 An01g10870 Aspergillus niger uncharacterized protein XP_059599780.1 2567143 R 5061 CDS An01g10880 4977072 complement(join(2570064..2570313,2570374..2570458,2570640..2570901)) II 1 NT_166518.1 Catalytic activity: ATP + H(2)O <=> ADP + phosphate.; Complex: the f-type ATPases have 2 components, Cf(1) - the catalytic core - and Cf(0) - the membrane proton channel. In S. cerevisiae, the dimeric form of ATP synthase consists of 18 polypeptides: alpha, beta, gamma, delta,epsilon, 4 (b), 5 (oscp), 6 (a), 8, 9 (c), d, e (tim11), f,g, h, i, j and k.; Function: the S. cerevisiae mitochondrial ATP synthase G chain (Atp20) is one of the chains of the nonenzymatic component (cf(0) subunit) of the mitochondrial ATPase complex.; Remark: alternate names for S. cerevisiae Atp20: YPR020W or mitochondrial ATP synthase G chain.; Title: similarity to ATP synthase subunit g homolog Atp20 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9857174; See PMID 10336613; uncharacterized protein 2570901 4977072 An01g10880 Aspergillus niger uncharacterized protein XP_001389505.1 2570064 R 5061 CDS An01g10890 84590094 join(2572542..2572613,2572696..2572754,2572980..2573268) II 1 NT_166518.1 hypothetical protein 2573268 84590094 An01g10890 Aspergillus niger hypothetical protein XP_059599781.1 2572542 D 5061 CDS An01g10900 4977891 join(2574425..2574571,2574632..2574699,2574773..2574885,2575214..2575242) II 1 NT_166518.1 Similarity: the similarities of the ORF encoded protein to all matching proteins are based on repetitive structures.; Title: similarity to hypothetical la costa protein lcs - Drosophila melanogaster; uncharacterized protein 2575242 4977891 An01g10900 Aspergillus niger uncharacterized protein XP_001389507.3 2574425 D 5061 CDS An01g10910 4978026 join(2576117..2576596,2576639..2576729,2576798..2577144) II 1 NT_166518.1 Catalytic activity: Catechol + O(2) <=> cis,cis-muconate.; Similarity: the ORF encoded protein is also similar to the sequence 379 from Patent WO0100842, but its function is not clearly enough decribed.; Title: similarity to catechol 1,2-dioxygenase alpha chain CatA - Pseudomonas sp.; See PMID 2295613; See PMID 7646060; uncharacterized protein 2577144 4978026 An01g10910 Aspergillus niger uncharacterized protein XP_059599782.1 2576117 D 5061 CDS An01g10920 4977395 join(2578961..2579127,2579195..2580188) II 1 NT_166518.1 Catalytic activity: L-iditol + NAD(+) <=> L-sorbose + NADH.; Cofactor: Zinc.; Complex: Homotetramer.; Pathway: the rat Sorbitol dehydrogenase SDH is involved in the fructose and mannose metabolism.; Remark: Sorbitol dehydrogenase=L-iditol 2-dehydrogenase.; Title: strong similarity to sorbitol dehydrogenase SDH - Rattus norvegicus; See PMID 8223590; See PMID 8761460; uncharacterized protein 2580188 4977395 An01g10920 Aspergillus niger uncharacterized protein XP_001389509.1 2578961 D 5061 CDS An01g10930 4977533 join(2581492..2581702,2581754..2582397,2582463..2582658,2582716..2582787,2582837..2583307,2583351..2583465,2583512..2584400) II 1 NT_166518.1 Function: the sugar transferase from patent JP11009276-A preferably catalyses the glucose transfer of an alpha-1 right arrow 3 bond or the glucose transfer of an alpha-1 right arrow 3 and an alpha-1 right arrow 4 bond to a sugar receptor by reacting with a substrate selected from starch and its decomposition products.; Similarity: the ORF DNA sequence shows also strong similarity to the A. niger EST an_3550.; Title: strong similarity to enzyme with sugar transferase activity from patent JP11009276-A - Acremonium sp.; uncharacterized protein 2584400 4977533 An01g10930 Aspergillus niger uncharacterized protein XP_059599783.1 2581492 D 5061 CDS An01g10940 4977974 join(2585065..2585239,2585317..2585390,2585466..2585519) II 1 NT_166518.1 hypothetical protein 2585519 4977974 An01g10940 Aspergillus niger hypothetical protein XP_001389511.1 2585065 D 5061 CDS An01g10950 4977184 complement(join(2585623..2585649,2585684..2586418)) II 1 NT_166518.1 Title: similarity to protein involved in nonactin biosynthesis NonF - Streptomyces griseus; See PMID 10650222; uncharacterized protein 2586418 4977184 An01g10950 Aspergillus niger uncharacterized protein XP_001389512.3 2585623 R 5061 CDS An01g10960 4977995 complement(join(2588228..2589082,2589318..2589380)) II 1 NT_166518.1 Function: the LigI gene product from Sphingomonas paucimobilis catalyzes the hydrolysis of 2-pyrone-4,6-dicarboxylic acid.; Pathway: the LigI 2-pyrone-4, 6-dicarboxylic acid hydrolase is involved in lignin degradation.; Title: strong similarity to 2-pyrone-4,6-dicarboxylic acid hydrolase LigI - Sphingomonas paucimobilis; See PMID 9864312; See PMID 11092855; uncharacterized protein 2589380 4977995 An01g10960 Aspergillus niger uncharacterized protein XP_001389513.3 2588228 R 5061 CDS An01g10970 4977516 join(2590434..2590527,2590597..2590950,2591009..2591077,2591144..2592213) II 1 NT_166518.1 Similarity: the N. crassa qa-y protein belongs to the maltose transport protein MAL61 superfamily.; Title: strong similarity to quinate transporter qa-y - Neurospora crassa; See PMID 1533844; uncharacterized protein 2592213 4977516 An01g10970 Aspergillus niger uncharacterized protein XP_001389514.1 2590434 D 5061 CDS An01g10980 4977979 complement(join(2592655..2593202,2593254..2593564,2593628..2594414,2594466..2594547,2594617..2595084,2595170..2595223,2595329..2595403)) II 1 NT_166518.1 Function: the N. crassa nit-4 protein pathway-specific regulatory gene of nitrate assimilation. It activates the transcription of the genes for nitrate and nitrite reductases.; Similarity: the nit-4 protein from N. crassa is a fungal Zn(2)-Cys(6) binuclear type transcription factor.; Title: strong similarity to nitrogen assimilation regulatory protein nit-4 - Neurospora crassa; nucleus; See PMID 7592372; See PMID 1840634; uncharacterized protein 2595403 4977979 An01g10980 Aspergillus niger uncharacterized protein XP_059599784.1 2592655 R 5061 CDS An01g10990 4977543 complement(2596246..2597826) II 1 NT_166518.1 Catalytic activity: ATP + L-threonine + tRNA(Thr) <=> AMP + diphosphate + L-threonyl-tRNA(Thr).; Remark: alternate name for S. cerevisiae Mst1: YKL194C.; Title: strong similarity to mitochondrial threonine--tRNA ligase Mst1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 2999113; uncharacterized protein 2597826 4977543 An01g10990 Aspergillus niger uncharacterized protein XP_001389516.1 2596246 R 5061 CDS An01g11000 4977917 2598426..2599793 II 1 NT_166518.1 Remark: alternate name for S. cerevisiae Aga1: YNR044W.; Title: weak similarity to agglutinin core protein Aga1 - Saccharomyces cerevisiae; uncharacterized protein 2599793 4977917 An01g11000 Aspergillus niger uncharacterized protein XP_001389517.1 2598426 D 5061 CDS An01g11010 4977513 complement(join(2600567..2601394,2601537..2601811,2601865..2601952)) II 1 NT_166518.1 Remark: alternate name for S. cerevisiae Crh1: YGR189C.; Title: strong similarity to cell wall protein Crh1 -Saccharomyces cerevisiae; cell wall; See PMID 10757808; uncharacterized protein 2601952 4977513 An01g11010 Aspergillus niger uncharacterized protein XP_001389518.1 2600567 R 5061 CDS An01g11020 84590095 complement(join(2603727..2603798,2604000..2604085,2604206..2604335,2604379..2604480)) II 1 NT_166518.1 hypothetical protein 2604480 84590095 An01g11020 Aspergillus niger hypothetical protein XP_059599785.1 2603727 R 5061 CDS An01g11030 84590096 complement(join(2604694..2604785,2604881..2604967,2605054..2605123)) II 1 NT_166518.1 hypothetical protein 2605123 84590096 An01g11030 Aspergillus niger hypothetical protein XP_059599786.1 2604694 R 5061 CDS An01g11070 4977171 complement(join(2609692..2610391,2610442..2610623,2610689..2610721)) II 1 NT_166518.1 Pathway: the (+)-pinoresinol/(+)-lariciresinol reductase PLR from Forsythia x intermedia is involved in the biosynthesis of lignins.; Remark: the PLR enzyme from Forsythia x intermedia is identical to the protein described in patent WO9820113-A1.; Title: similarity to the +pinoresinol/+lariciresinol reductase PLR - Forsythia x intermedia; See PMID 8910615; uncharacterized protein 2610721 4977171 An01g11070 Aspergillus niger uncharacterized protein XP_001389521.1 2609692 R 5061 CDS An01g11080 4977781 complement(join(2611909..2612292,2612352..2612950,2613044..2613274,2613335..2614013)) II 1 NT_166518.1 Catalytic activity: ATP + a protein <=> ADP + a phosphoprotein.; Function: the Wis1 protein from S. pombe is a dosage-dependent regulator of mitosis with serine/threonine protein kinase activity. it may play a role in the integration of nutritional sensing with the control over entry into mitosis.; Remark: in S. pombe, the Wis1-Sty1 MAP (mitogen-activated protein) kinase signaling cascade is known to play a major role in cellular adaptation to adverse external stimuli, including osmotic stress,oxidative stress, nutrient deprivation, DNA-damaging agents, and heat stress.; Title: strong similarity to MAP kinase kinase wis1p - Schizosaccharomyces pombe; deleted EC_number 2.7.1.37; See PMID 9693384; See PMID 1756736; uncharacterized protein 2614013 4977781 An01g11080 Aspergillus niger uncharacterized protein XP_059599787.1 2611909 R 5061 CDS An01g11090 84590097 complement(join(2614796..2614834,2614922..2615050,2615283..2615324,2615473..2615606,2615742..2615833,2615896..2616044)) II 1 NT_166518.1 Title: weak similarity to de novo DNA cytosine methyltransferase Dnmt3a from patent WO9967397-A1 - Mus sp.; uncharacterized protein 2616044 84590097 An01g11090 Aspergillus niger uncharacterized protein XP_059603306.1 2614796 R 5061 CDS An01g11100 4978048 join(2617966..2618176,2618236..2618402,2618479..2618852,2619183..2619692,2619748..2619817) II 1 NT_166518.1 Similarity: the ORF encoded protein shows strong similarity to the hypothetical protein SPAC5D6. 04 (S. pombe).; Title: strong similarity to hypothetical membrane protein YBR287w - Saccharomyces cerevisiae; uncharacterized protein 2619817 4978048 An01g11100 Aspergillus niger uncharacterized protein XP_059603307.1 2617966 D 5061 CDS An01g11120 4977799 complement(join(2621286..2621576,2621632..2622049,2622108..2622296,2622349..2622413,2622477..2622506,2622557..2622885,2622940..2623056,2623107..2623428)) II 1 NT_166518.1 Function: the S. cerevisiae Fet5 protein is a iron transport multicopper oxidase, which is required for ferrous iron high affinity uptake. It may be required to oxidize Fe(II) and release it from the transporter. It is an essential component of copper-dependent iron transport.; Remark: alternate name for S. cerevisiae Fet5: YFL041W.; Title: strong similarity to multicopper ferroxidase iron transport mediator Fet5 - Saccharomyces cerevisiae; See PMID 9413439; uncharacterized protein 2623428 4977799 An01g11120 Aspergillus niger uncharacterized protein XP_059603308.1 2621286 R 5061 CDS An01g11130 4977090 join(2624315..2624364,2624482..2624603,2624635..2624769,2624850..2625058,2625107..2625230,2625356..2625685,2625737..2625847,2625897..2626099,2626154..2626626,2626700..2626796) II 1 NT_166518.1 Catalytic activity: a phosphatidylcholine + H(2)O <=> 1,2-diacylglycerol+ choline phosphate.; Cofactor: Zinc.; Pathway: the non-hemolytic phospholipase C from B. pseudomallei is involved in phospholipid degradation.; Title: strong similarity to non-hemolytic phospholipase C - Burkholderia pseudomallei; See PMID 10523590; uncharacterized protein 2626796 4977090 An01g11130 Aspergillus niger uncharacterized protein XP_059603309.1 2624315 D 5061 CDS An01g11140 4977215 2627127..2627579 II 1 NT_166518.1 Function: the probable acetyl transferase ORF5 is one of six genes found to be responsible for IAA (indole-3-acetic) production in Azospirillum brasilense.; Title: similarity to acetyl transferase of an indole-3-acetic acid producing gene cluster ORF5 -Azospirillum brasilense; See PMID 1896020; uncharacterized protein 2627579 4977215 An01g11140 Aspergillus niger uncharacterized protein XP_001389527.1 2627127 D 5061 CDS An01g11150 4978072 join(2629390..2629438,2629674..2630554,2630644..2631180,2631227..2631370,2631421..2631639,2631754..2632083) II 1 NT_166518.1 Catalytic activity: ATP + choline <=> ADP + O-phosphocholine.; Function: the choline kinase Cki1 from S. cerevisiae is responsible for phosphatidylcholine synthesis via the CDP-choline pathway. It also exhibits ethanolamine kinase activity but at 14% efficiency compared with choline.; Pathway: S. cerevisiae Cki1 is involved in the CDP-choline and CDP-ethanolamine dependent pathways of the phospholipid biosynthesis.; Remark: alternate name for S. cerevisiae Cki1: YLR133W.; Title: strong similarity to choline kinase Cki1 -Saccharomyces cerevisiae; See PMID 10092638; See PMID 2536698; uncharacterized protein 2632083 4978072 An01g11150 Aspergillus niger uncharacterized protein XP_059603310.1 2629390 D 5061 CDS An01g11160 4977853 complement(join(2632147..2632168,2632285..2633106,2633166..2633260,2633323..2633364)) II 1 NT_166518.1 Catalytic activity: ubiquitin C-terminal thiolester + H(2)O <=> ubiquitin + a thiol.; Remark: the human ubiquitin carboxyl-terminal hydrolase BAP1 is also described in patent WO9805968-A1.; Title: strong similarity to ubiquitin carboxyl-terminal hydrolase BAP1 - Homo sapiens; See PMID 9528852; uncharacterized protein 2633364 4977853 An01g11160 Aspergillus niger uncharacterized protein XP_001389529.3 2632147 R 5061 CDS An01g11170 4977554 2634163..2634480 II 1 NT_166518.1 hypothetical protein 2634480 4977554 An01g11170 Aspergillus niger hypothetical protein XP_001389530.1 2634163 D 5061 CDS An01g11180 4977849 complement(join(2635018..2635069,2635145..2635430,2635477..2635682,2635733..2636063,2636116..2636206,2636259..2636655,2636714..2636937)) II 1 NT_166518.1 Catalytic activity: (R)-6-hydroxynicotine + H(2)O + O(2) <=> 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H(2)O(2).; Cofactor: FAD.; Title: similarity to 6-hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 3622516; See PMID 2680607; uncharacterized protein 2636937 4977849 An01g11180 Aspergillus niger uncharacterized protein XP_001389531.3 2635018 R 5061 CDS An01g11190 4977044 join(2637374..2637484,2637547..2637771,2637835..2638213,2638268..2638342,2638411..2638733) II 1 NT_166518.1 Function: for Pth11 from M. grisea it is suggested that it functions at the cell cortex as an upstream effector of appressorium differentiation in response to surface cues.; Title: similarity to plasma membrane protein Pth11 -Magnaporthe grisea; plasma membrane; See PMID 10521529; uncharacterized protein 2638733 4977044 An01g11190 Aspergillus niger uncharacterized protein XP_059603311.1 2637374 D 5061 CDS An01g11200 4977540 join(2639545..2639792,2639845..2640182,2640242..2640561,2640612..2640852,2640908..2641098) II 1 NT_166518.1 Remark: SRPK family members may be uniquely regulated and targeted, thereby contributing to splicing regulation in different tissues, during development, or in response to signaling.; Remark: higher eukaryotes are showing similar genes but are approximately 100-150 amino acids longer.; Remark: reversible phosphorylation plays an important role in pre-mRNA splicing in mammalian cells.; Title: strong similarity to serine kinase SRPK2 -Homo sapiens; See PMID 9472028; uncharacterized protein 2641098 4977540 An01g11200 Aspergillus niger uncharacterized protein XP_059603312.1 2639545 D 5061 CDS An01g11210 84590098 complement(join(2641855..2642049,2642462..2642557,2642657..2642740)) II 1 NT_166518.1 hypothetical protein 2642740 84590098 An01g11210 Aspergillus niger hypothetical protein XP_059603313.1 2641855 R 5061 CDS An01g11220 10098241 complement(join(2643186..2643250,2643424..2643637)) II 1 NT_166518.1 Title: weak similarity to hypothetical protein encoded by An07g02370 - Aspergillus niger; uncharacterized protein 2643637 10098241 An01g11220 Aspergillus niger uncharacterized protein XP_059603314.1 2643186 R 5061 CDS An01g11240 4978342 complement(join(2644898..2645014,2645062..2645119,2645173..2645213)) II 1 NT_166518.1 Remark: the ORF is short in length (71 amino acids).; hypothetical protein 2645213 4978342 An01g11240 Aspergillus niger hypothetical protein XP_059603315.1 2644898 R 5061 CDS An01g11250 4978481 join(2646244..2646892,2647617..2647663,2647715..2649505) II 1 NT_166518.1 Title: weak similarity to intestinal mucin MUC3 -Homo sapiens; uncharacterized protein 2649505 4978481 An01g11250 Aspergillus niger uncharacterized protein XP_059603316.1 2646244 D 5061 CDS An01g11260 4978486 complement(join(2649764..2650206,2650301..2650463,2650509..2650554,2650725..2650982,2651035..2652156,2652287..2652483)) II 1 NT_166518.1 Remark: STB5 encodes a C6 zinc cluster DNA-binding protein which interacts with the sin3 transcriptional repressor.; Title: similarity to regulator protein Stb5 -Saccharomyces cerevisiae; See PMID 9393435; See PMID 10961924; uncharacterized protein 2652483 4978486 An01g11260 Aspergillus niger uncharacterized protein XP_059603317.1 2649764 R 5061 CDS An01g11270 4978465 join(2652964..2653015,2653092..2653862,2653930..2654063) II 1 NT_166518.1 Remark: removes carboxyl groups from ring mounted carboxyls, particularly in the production of catechol.; Remark: similarity to A. niger 2,3-dihydroxybenzoic acid decarboxylase protein patent WO9909048-A1.; Title: similarity to 2,3-dihydroxybenzoic acid decarboxylase from patent WO9909048-A1 - Aspergillus niger; uncharacterized protein 2654063 4978465 An01g11270 Aspergillus niger uncharacterized protein XP_001389539.1 2652964 D 5061 CDS An01g11280 10098160 complement(join(2654308..2654561,2654617..2654743,2654775..2654966,2655073..2655327,2655387..2655715,2655796..2656197,2656277..2656448)) II 1 NT_166518.1 Catalytic activity: cyclohexanone + NADPH + O2 = 6-hexanolide + NADP+ + H2O.; Pathway: caprolactam degradation.; Remark: putative sequencing error at position 17435,generating a stop codon.; Remark: the activity of estf1 P. fluorescens increased from gamma-butyrolactone (18. 1 U/mg) to epsilon-caprolactone (21. 8 U/mg) to delta-valerolactone (36. 5 U/mg). The activities towards the aliphatic esters were significantly lower; the only exception was the activity toward ethyl caprylate, which was the preferred substrate.; Similarity: to cyclohexanone monooxygenase proteins in different organisms.; Title: similarity to lactone-specific esterase estf1 - Pseudomonas fluorescens [putative sequencing error]; putative sequencing error; See PMID 9925571; uncharacterized protein 2656448 10098160 An01g11280 Aspergillus niger uncharacterized protein XP_059603318.1 2654308 R 5061 CDS An01g11290 4978312 join(2658082..2658291,2658358..2659860) II 1 NT_166518.1 Remark: CFP encodes a cercosporin transporter that contributes resistance to cercosporin by actively exporting cercosporin, thus maintaining low cellular concentrations of the toxin.; Remark: many species of the fungal genus Cercospora,including the soybean pathogen C. kikuchii, produce the phytotoxic polyketide cercosporin.; Similarity: to multidrug resistance transporter proteins of the major facilitator superfamily.; Title: strong similarity to cercosporin transporter CFP - Cercospora kikuchii; See PMID 10517030; uncharacterized protein 2659860 4978312 An01g11290 Aspergillus niger uncharacterized protein XP_001389541.1 2658082 D 5061 CDS An01g11300 84590099 join(2660482..2660588,2660667..2660800,2660885..2661030,2661113..2661268) II 1 NT_166518.1 hypothetical protein 2661268 84590099 An01g11300 Aspergillus niger hypothetical protein XP_059603319.1 2660482 D 5061 CDS An01g11310 4977478 join(2661733..2661834,2661893..2661919,2661975..2663060) II 1 NT_166518.1 Similarity: the ORF shows similarity to several transcription regulators.; Title: weak similarity to sterigmatocystin synthesis transcription regulator aflR - Aspergillus nidulans; See PMID 8662194; uncharacterized protein 2663060 4977478 An01g11310 Aspergillus niger uncharacterized protein XP_001389543.1 2661733 D 5061 CDS An01g11320 4977632 complement(2663386..2663715) II 1 NT_166518.1 Catalytic activity: L-tryptophan = tryptamine + CO2.; Pathway: histidine metabolism; tyrosine metabolism; phenylalanine metabolism; tryptophan metabolism; alkaloid biosynthesis I.; Remark: DDC3 is used to increase the production of polypeptides by recombinant host filamentous fungal cells.; Remark: similarity to DDC3 (dopa decarboxylase 3) from Aspergillus oryzae patent WO9960136-A1.; Title: similarity to dopa decarboxylase 3 DDC3 from patent WO9960136-A1 - Aspergillus oryzae; uncharacterized protein 2663715 4977632 An01g11320 Aspergillus niger uncharacterized protein XP_001389544.1 2663386 R 5061 CDS An01g11330 4977862 join(2664651..2664670,2664729..2665431) II 1 NT_166518.1 Title: strong similarity to hypothetical protein CAD70322.1 - Neurospora crassa; uncharacterized protein 2665431 4977862 An01g11330 Aspergillus niger uncharacterized protein XP_001389545.1 2664651 D 5061 CDS An01g11340 4977276 complement(join(2665532..2665629,2665687..2666233,2666308..2666627,2666679..2666709,2666763..2666906)) II 1 NT_166518.1 Catalytic activity: release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.; Remark: deletion of the yeast MAP1 gene is not lethal, suggesting that alternative NH2-terminal processing pathway(s) exist for cleaving methionine from nascent polypeptide chains in eukaryotic cells.; Similarity: belongs to the Escherichia coli methionyl aminopeptidase family.; Title: strong similarity to methionyl aminopeptidase Map1 - Saccharomyces cerevisiae; See PMID 1569059; uncharacterized protein 2666906 4977276 An01g11340 Aspergillus niger uncharacterized protein XP_001389546.1 2665532 R 5061 CDS An01g11350 84590100 join(2667238..2667318,2667400..2667657) II 1 NT_166518.1 hypothetical protein 2667657 84590100 An01g11350 Aspergillus niger hypothetical protein XP_059603320.1 2667238 D 5061 CDS An01g11360 4977825 join(2667667..2667709,2667765..2667926,2667993..2668597,2668647..2669120,2669171..2669257,2669306..2669362) II 1 NT_166518.1 Catalytic activity: release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.; Remark: lower and higher eukaryotes, as well as bacteria, share a similar N-terminal protein processing machinery, indicating universality of this system.; Remark: the N-terminal protein processing pathway is an essential mechanism found in all organisms.; Remark: the trembl:AF250964_1 is putative the same as pir:T00698 exept the different 9 amino acids before the start methionine.; Similarity: to human methionyl aminopeptidase.; Title: strong similarity to methionine aminopeptidase-like protein F6E13.31 - Arabidopsis thaliana; See PMID 11060042; uncharacterized protein 2669362 4977825 An01g11360 Aspergillus niger uncharacterized protein XP_059603321.1 2667667 D 5061 CDS An01g11370 4977402 complement(join(2671224..2671471,2671568..2672303,2672364..2672739,2672834..2673477,2673532..2673703,2673736..2673740,2673781..2673837)) II 1 NT_166518.1 Remark: genetic analysis and GFP fusions show that the NLS of a Zn-binuclear cluster transcriptional activator of Aspergillus nidulans (PrnA) is tripartite.; Remark: the prnA gene A. nidulans codes for a transcriptional activator that mediates proline induction of four other genes involved in proline utilization as a nitrogen and/or carbon source in Aspergillus nidulans.; Title: similarity to transcription activator prnA -Aspergillus nidulans; See PMID 9622360; See PMID 10788322; uncharacterized protein 2673837 4977402 An01g11370 Aspergillus niger uncharacterized protein XP_059603322.1 2671224 R 5061 CDS An01g11380 4977091 complement(join(2674688..2675365,2675441..2675704)) II 1 NT_166518.1 Title: strong similarity to sequence 1 from patent EP0845532 - Pseudomonas sp.; uncharacterized protein 2675704 4977091 An01g11380 Aspergillus niger uncharacterized protein XP_001389550.1 2674688 R 5061 CDS An01g11390 4977335 join(2676438..2676506,2676561..2676692,2676771..2677048,2677152..2677344,2677413..2677972,2678072..2678162) II 1 NT_166518.1 Remark: probable nadh-dependent flavin oxidoreductase.; Title: strong similarity to sequence 385 from patent WO0100842 - Corynebacterium glutamicum; uncharacterized protein 2678162 4977335 An01g11390 Aspergillus niger uncharacterized protein XP_059603323.1 2676438 D 5061 CDS An01g11400 4977642 join(2678225..2678449,2678494..2678740,2678789..2678870,2679022..2679078,2679348..2679547,2679613..2679765,2679824..2679929,2679971..2680633,2680701..2681223,2681289..2681978) II 1 NT_166518.1 Remark: only a small domain is homolog to many different proteins.; Title: weak similarity to hypothetical protein encoded by An02g00880 - Aspergillus niger; uncharacterized protein 2681978 4977642 An01g11400 Aspergillus niger uncharacterized protein XP_001389552.3 2678225 D 5061 CDS An01g11410 4977064 join(2683323..2683399,2683435..2683684,2683748..2684030,2684097..2684377) II 1 NT_166518.1 Title: strong similarity to hypothetical protein BAB49374.1 - Mesorhizobium loti; uncharacterized protein 2684377 4977064 An01g11410 Aspergillus niger uncharacterized protein XP_059603324.1 2683323 D 5061 CDS An01g11420 4977997 join(2685689..2686251,2686318..2686510) II 1 NT_166518.1 hypothetical protein 2686510 4977997 An01g11420 Aspergillus niger hypothetical protein XP_001389554.1 2685689 D 5061 CDS An01g11430 4977021 join(2687512..2687621,2687682..2689098) II 1 NT_166518.1 Remark: weak similarity to cell surface proteins with repetetive sequences.; Title: weak similarity to S-layer protein -Clostridium thermocellum; uncharacterized protein 2689098 4977021 An01g11430 Aspergillus niger uncharacterized protein XP_001389555.3 2687512 D 5061 CDS An01g11440 4978381 2690197..2691033 II 1 NT_166518.1 Catalytic activity: UDPglucose = UDPgalactose.; Pathway: galactose metabolism; nucleotide sugars metabolism.; Remark: null mutant of gal10 S. cerevisiae is viable and cannot utilize galactose.; Similarity: belongs to the UDPglucose 4-epimerase family; Title: similarity to UDPglucose 4-epimerase Gal10 -Saccharomyces cerevisiae; See PMID 6092912; See PMID 6715281; uncharacterized protein 2691033 4978381 An01g11440 Aspergillus niger uncharacterized protein XP_001389556.3 2690197 D 5061 CDS An01g11450 4977238 join(2691545..2691571,2691722..2692105,2692160..2692253,2692300..2692499,2692545..2692618,2692663..2692767,2692816..2692988,2693043..2693206,2693263..2693566,2693631..2693821,2693871..2693942) II 1 NT_166518.1 Remark: ophD encodes a permease for phthalate transport.; Similarity: to putative allantoate transporter proteins from different organisms.; Title: strong similarity to phthalate permease ophD - Burkholderia cepacia; See PMID 10498738; uncharacterized protein 2693942 4977238 An01g11450 Aspergillus niger uncharacterized protein XP_059603325.1 2691545 D 5061 CDS An01g11470 4977775 join(2695001..2695731,2695789..2695866,2695923..2696103) II 1 NT_166518.1 Title: similarity to hypothetical protein encoded by An08g09690 - Aspergillus niger; uncharacterized protein 2696103 4977775 An01g11470 Aspergillus niger uncharacterized protein XP_001389558.1 2695001 D 5061 CDS An01g11480 4977597 join(2697125..2697202,2697285..2697727,2697786..2697984,2698040..2698714,2698790..2699017,2699107..2699277) II 1 NT_166518.1 Remark: RT-PCR experiments confirm that ox1 is expressed under conditions of peptide alkaloid biosynthesis.; Remark: the ox1 is 100 aa shorter in the N-terminal region, but all other similaritys are shown to oxidoreductases with different substrate specificity.; Title: strong similarity to oxidoreductase ox1 -Claviceps purpurea; See PMID 10071219; uncharacterized protein 2699277 4977597 An01g11480 Aspergillus niger uncharacterized protein XP_001389559.1 2697125 D 5061 CDS An01g11500 84590101 join(2700528..2701149,2701366..2702714) II 1 NT_166518.1 Similarity: the ORF shows weak similarity to the hypothetical protein C33D9. 8 of C. elegans.; Title: weak similarity to hypothetical protein encoded by An16g04050 - Aspergillus niger; uncharacterized protein 2702714 84590101 An01g11500 Aspergillus niger uncharacterized protein XP_059603326.1 2700528 D 5061 CDS An01g11510 4977755 2703374..2704912 II 1 NT_166518.1 Catalytic activity: Hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.; Pathway: glycosaminoglycan degradation.; Remark: it is a periplasmic enzyme and acts as homodimer.; Remark: mucin desulfation is believed to be a rate-limiting step in mucin degradation by colon bacteria.; Title: strong similarity to mucin-desulfating sulfatase MdsA - Prevotella sp.; See PMID 10809675; See PMID 10981693; uncharacterized protein 2704912 4977755 An01g11510 Aspergillus niger uncharacterized protein XP_001389561.1 2703374 D 5061 CDS An01g11520 4978020 join(2707839..2708066,2708119..2708538,2708601..2709059) II 1 NT_166518.1 Catalytic activity: random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans.; Gene-ID: pgaI; Pathway: pentose and glucuronate interconversions; starch and sucrose metabolism.; Remark: strong similarity to prepro-polygalacturonase I patent EP421919-A from Aspergillus niger.; See PMID 10945680; See PMID 1934135; polygalacturonase pgaI-Aspergillus niger 2709059 pgaI 4978020 pgaI Aspergillus niger polygalacturonase pgaI-Aspergillus niger XP_001389562.1 2707839 D 5061 CDS An01g11530 4978341 complement(join(2711739..2712332,2712376..2712904,2712967..2713085)) II 1 NT_166518.1 Remark: AWI 31 was specifically induced by wounding.; Remark: not regulated by other environmental stresses such as drought, high salt, low temperature, or a DPE herbicide treatment.; Title: similarity to induced upon wounding stress protein AWI 31 - Arabidopsis thaliana; See PMID 9085278; uncharacterized protein 2713085 4978341 An01g11530 Aspergillus niger uncharacterized protein XP_059603327.1 2711739 R 5061 CDS An01g11540 4977325 join(2714648..2714805,2714872..2715990,2716071..2716292,2716504..2716711) II 1 NT_166518.1 Remark: expression of FLU1 in YKKB-13 mediated not only resistance to fluconazole but also to cycloheximide.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353; See PMID 11181345; uncharacterized protein 2716711 4977325 An01g11540 Aspergillus niger uncharacterized protein XP_001389564.3 2714648 D 5061 CDS An01g11550 4977701 complement(join(2717238..2717381,2717435..2718808,2718882..2718941)) II 1 NT_166518.1 Title: strong similarity to hypothetical protein CAD21353.1 - Neurospora crassa; uncharacterized protein 2718941 4977701 An01g11550 Aspergillus niger uncharacterized protein XP_001389565.1 2717238 R 5061 CDS An01g11560 84590102 complement(2719315..2720877) II 1 NT_166518.1 Catalytic activity: Digallate + H2O = 2 Gallate.; Remark: also hydrolyses ester links in other tannins.; Remark: similarity to Aspergillus oryzae tannase protein patent JP08080196-A.; Remark: tannase gene product is translated as a single polypeptide that is cleaved by post-translational modification into two tannase subunits linked by a disulfide bond(s).; Remark: tannins have a wide range of effects on various organisms--from toxic effects on animals to growth inhibition of microorganisms.; Remark: the tannase can be used for clarification in beer production.; Title: strong similarity to precursor of tannase -Aspergillus oryzae; See PMID 8917102; See PMID 10192896; See PMID 11191769; uncharacterized protein 2720877 84590102 An01g11560 Aspergillus niger uncharacterized protein XP_059603328.1 2719315 R 5061 CDS An01g11570 4977937 complement(join(2721285..2721817,2722089..2722219,2722267..2722508)) II 1 NT_166518.1 Similarity: the ORF shows weak similarity to the DNA binding protein Ncp1 of Ustilago maydis.; Title: similarity to hypothetical protein encoded by An01g11580 - Aspergillus niger; uncharacterized protein 2722508 4977937 An01g11570 Aspergillus niger uncharacterized protein XP_059603329.1 2721285 R 5061 CDS An01g11580 4977677 complement(join(2725016..2725187,2725249..2725661)) II 1 NT_166518.1 Title: similarity to hypothetical protein encoded by An01g11570 - Aspergillus niger; uncharacterized protein 2725661 4977677 An01g11580 Aspergillus niger uncharacterized protein XP_001389568.1 2725016 R 5061 CDS An01g11590 4977764 join(2726697..2726699,2726750..2728054) II 1 NT_166518.1 Title: similarity to hypothetical protein encoded by An01g01670 - Aspergillus niger; uncharacterized protein 2728054 4977764 An01g11590 Aspergillus niger uncharacterized protein XP_059603330.1 2726697 D 5061 CDS An01g11600 4977671 complement(join(2728324..2728348,2728412..2728608,2728669..2729076,2729143..2729512,2729572..2729781,2729856..2729905,2729955..2730048,2730101..2730267)) II 1 NT_166518.1 Remark: DAL5 encodes a component of the allantoate transport system.; Remark: its relatively high basal level of expression did not increase further upon addition of allantoin pathway intermediates.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 10869563; See PMID 3275614; See PMID 3301804; uncharacterized protein 2730267 4977671 An01g11600 Aspergillus niger uncharacterized protein XP_059603331.1 2728324 R 5061 CDS An01g11610 4977600 join(2731358..2731471,2731529..2731934,2732032..2732380,2732430..2732557,2732606..2732835) II 1 NT_166518.1 Remark: the Pyrococcus horikoshii enzyme has the following properties: an aminoacylase activity and a carboxypeptidase activity.; Remark: the protein shows also similarity to Pyrococcus horikoshii enzyme, patent JP10210976-A.; Title: similarity to indole-3-acetyl-L-aspartic acid hydrolase IAA-asp - Enterobacter agglomerans; See PMID 9747708; See PMID 10651904; uncharacterized protein 2732835 4977600 An01g11610 Aspergillus niger uncharacterized protein XP_059603332.1 2731358 D 5061 CDS An01g11620 4977728 join(2733525..2733558,2733673..2734651,2734697..2734997,2735049..2735492) II 1 NT_166518.1 Remark: the expression of the structural genes for lysine (LYS) biosynthesis is controlled by a pathway-specific regulation mediated by the transcriptional activator Lys14 in the presence of alpha-aminoadipate semialdehyde, an intermediate of the pathway acting as a co-inducer.; Remark: the protein belongs to a fungal regulatory familiy containing the Zn(II)2Cys6 binuclear cluster DNA binding domain.; Title: similarity to transcription activator of lysine pathway Lys14 - Saccharomyces cerevisiae; See PMID 9701810; See PMID 10975256; uncharacterized protein 2735492 4977728 An01g11620 Aspergillus niger uncharacterized protein XP_001389572.1 2733525 D 5061 CDS An01g11630 4978013 complement(join(2737048..2737088,2737153..2737239,2737302..2737386)) II 1 NT_166518.1 Function: Sss1 from S. cerevisiae is required for continued translocation of secretory precursor proteins through the ER membrane.; Function: overexpressed SSS1 from S. cerevisiae restores translocation in the sec61 mutant.; Localization: Sss1 from S. cerevisiae is firmly bound to the ER membrane and exposes its amino-terminal half on the cytosolic side.; Remark: Sss1 from S. cerevisiae interacts directly with Sec61, a 10-transmembrane-domain membrane protein of the heterotrimeric Sec61p complex.; Remark: the evolutionarily conserved Sec61 protein complex mediates the translocation of secretory proteins into the endoplasmic reticulum.; Title: strong similarity to translocation complex component Sss1 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 7961662; See PMID 8223425; See PMID 9303299; uncharacterized protein 2737386 4978013 An01g11630 Aspergillus niger uncharacterized protein XP_001389573.1 2737048 R 5061 CDS An01g11640 4977519 join(2738527..2738934,2738981..2739967) II 1 NT_166518.1 Remark: MEP2 is an ammonium sensor, generating a signal to regulate filamentous growth in response to ammonium starvation.; Remark: MEP2, a high affinity ammonium permease, is required for pseudohyphal differentiation in response to ammonium limitation.; Title: strong similarity to high affinity low capacity ammonia permease Mep2 - Saccharomyces cerevisiae; See PMID 9234685; See PMID 9482721; uncharacterized protein 2739967 4977519 An01g11640 Aspergillus niger uncharacterized protein XP_059603333.1 2738527 D 5061 CDS An01g11650 4978173 complement(2740057..2740908) II 1 NT_166518.1 Catalytic activity: 10-Formyltetrahydrofolate + H2O = Formate + Tetrahydrofolate.; Pathway: glyoxylate and dicarboxylate metabolism; one carbon pool by folate.; Remark: also strong similarity to formate transport associated protein, PurU - Bacillus subtilis from patent WO9927107-A2.; Remark: it appears that PurU provides the major source of formate for the purT-dependent synthesis of FGAR.; Title: strong similarity to formyltetrahydrofolate deformylase purU - Corynebacterium sp.; See PMID 7543100; uncharacterized protein 2740908 4978173 An01g11650 Aspergillus niger uncharacterized protein XP_001389575.1 2740057 R 5061 CDS An01g11660 4977345 2741545..2743155 II 1 NT_166518.1 Catalytic activity: hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.; Gene-ID: cbhB; Mapping: cbhB from A. niger is mapped to chromosome II; see list from DSM, EMBL AF156269.; Pathway: starch and sucrose metabolism.; Remark: northern blot analysis showed that the transcription of the cbhA and cbhB genes is induced by D-xylose but not by sophorose and, in addition, requires the xylanolytic transcriptional activator XlnR.; Remark: patent cbhB WO9906574-A1.; Remark: the differences in the sequence are caused by strain variations or sequencing errors.; See PMID 10508057; 1,4-beta-D-glucan cellobiohydrolase B precursor cbhB-Aspergillus niger 2743155 cbhB 4977345 cbhB Aspergillus niger 1,4-beta-D-glucan cellobiohydrolase B precursor cbhB-Aspergillus niger XP_001389576.1 2741545 D 5061 CDS An01g11670 4977614 join(2743874..2743964,2744020..2744231,2744294..2744358,2744421..2744518,2744571..2745337) II 1 NT_166518.1 Catalytic activity: endohydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.; Pathway: starch and sucrose metabolism; Remark: also hydrolyse 1,4-linkages in beta-D-glucans also containing 1,3-linkages.; Title: strong similarity to endo-beta-1,4-glucanase A eglA - Aspergillus nidulans; See PMID 10386374; uncharacterized protein 2745337 4977614 An01g11670 Aspergillus niger uncharacterized protein XP_001389577.1 2743874 D 5061 CDS An01g11680 4978234 join(2746204..2746347,2746401..2746509,2746560..2747363,2747419..2747468) II 1 NT_166518.1 Catalytic activity: 3-Carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-Carboxy-cis,cis-muconate.; Pathway: phenylalanine metabolism; Remark: the stereochemical and regiochemical course of the reaction is (i) opposite that of CMLE from Pseudomonas putida (EC 5. 5. 1. 2) and (ii) identical to that of cis,cis-muconate lactonizing enzyme (MLE; EC 5. 5. 1. 1) from P. putida.; Title: strong similarity to carboxy-cis,cis-muconate cyclase CMLE - Neurospora crassa; See PMID 4448182; See PMID 4448183; See PMID 8132467; uncharacterized protein 2747468 4978234 An01g11680 Aspergillus niger uncharacterized protein XP_001389578.3 2746204 D 5061 CDS An01g11690 4977935 complement(join(2748829..2749474,2749538..2749935,2749996..2750100,2750165..2750314)) II 1 NT_166518.1 Remark: Pth11p functions at the cell cortex as an upstream effector of appressorium differentiation in response to surface cues.; Remark: inhibition of of the genes PTH2, PTH3, PTH11 and PTH12 results in the reduction or elimination of the pathogenic phenotype of the fungus. The genes are useful in the design of screens to identify inhibitors of the fungal pathogenic gene products.; Remark: similarity to integral membrane protein PTH11 - Magnaporthe grisea patent WO9913094-A2.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529; uncharacterized protein 2750314 4977935 An01g11690 Aspergillus niger uncharacterized protein XP_059603334.1 2748829 R 5061 CDS An01g11700 84590103 complement(join(2751323..2751672,2751743..2752031)) II 1 NT_166518.1 Title: weak similarity to BPP-CNP precursor homolog - Agkistrodon blomhoffi; uncharacterized protein 2752031 84590103 An01g11700 Aspergillus niger uncharacterized protein XP_059603335.1 2751323 R 5061 CDS An01g11710 84590104 join(2754354..2754387,2754471..2754752,2754796..2754988,2755038..2755164) II 1 NT_166518.1 Remark: the similarity partially located in the middle of the protein.; Title: weak similarity to alpha-glucoside-hydrogen symporter Mal11 - Saccharomyces cerevisiae; See PMID 8594329; uncharacterized protein 2755164 84590104 An01g11710 Aspergillus niger uncharacterized protein XP_059603336.1 2754354 D 5061 CDS An01g11720 84590105 complement(join(2756300..2759092,2759327..2759373,2759542..2759584,2759642..2759704,2759870..2759987,2760285..2760383,2760419..2760477)) II 1 NT_166518.1 Title: strong similarity to hypothetical protein YPL206c - Saccharomyces cerevisiae; uncharacterized protein 2760477 84590105 An01g11720 Aspergillus niger uncharacterized protein XP_059603337.1 2756300 R 5061 CDS An01g11730 84590106 join(2761042..2761061,2761130..2761229,2761298..2761394,2761446..2761522) II 1 NT_166518.1 hypothetical protein 2761522 84590106 An01g11730 Aspergillus niger hypothetical protein XP_059603338.1 2761042 D 5061 CDS An01g11740 4977458 complement(join(2761724..2762637,2762689..2762901,2762956..2763178)) II 1 NT_166518.1 Alternative name: Microsomal dipeptidase. Renal dipeptidase. Dehydropeptidase I. DPH I.; Cofactor: zinc; Function: hydrolysis of dipeptides. Hydrophobic dipeptides are cleaved preferentially, including prolyl amino acids.; Localization: membrane bound, with broad specificity.; Remark: inhibited by bestatin and cilastatin.; Similarity: belongs to peptidase family M19.; Title: strong similarity to hypothetical membrane dipeptidase - Schizosaccharomyces pombe; uncharacterized protein 2763178 4977458 An01g11740 Aspergillus niger uncharacterized protein XP_001389584.1 2761724 R 5061 CDS An01g11750 4977391 complement(2763850..2764668) II 1 NT_166518.1 Similarity: the ORF shows also weak similarity to the protein-tyrosine kinase homolog btl of D. melanogaster and to tyrosine-kinases of other species.; Title: weak similarity to polypeptide SEQ ID NO:41298 from patent WO200171042-A2 - Drosophila melanogaster; uncharacterized protein 2764668 4977391 An01g11750 Aspergillus niger uncharacterized protein XP_001389585.1 2763850 R 5061 CDS An01g11760 4977532 join(2767048..2767060,2767319..2767530,2767591..2768829) II 1 NT_166518.1 Title: similarity to polypeptide SEQ ID NO:6405 from patent WO200171042-A2 - Drosophila melanogaster; uncharacterized protein 2768829 4977532 An01g11760 Aspergillus niger uncharacterized protein XP_001389586.3 2767048 D 5061 CDS An01g11770 84590107 complement(join(2769004..2771145,2771212..2771670)) II 1 NT_166518.1 Remark: N-methyl peptide synthetase.; Remark: probable a short peptid synthetase.; Title: similarity to peptide synthase enniatin synthase esyn1 - Fusarium scirpi; See PMID 8483420; See PMID 11085259; See PMID 7601090; uncharacterized protein 2771670 84590107 An01g11770 Aspergillus niger uncharacterized protein XP_059603339.1 2769004 R 5061 CDS An01g11780 4977945 2772835..2773473 II 1 NT_166518.1 Similarity: TO PROTEINS WITH A CORE MUTT DOMAIN.; Title: weak similarity to dATP pyrophosphohydrolase NMB0642 - Neisseria meningitidis; uncharacterized protein 2773473 4977945 An01g11780 Aspergillus niger uncharacterized protein XP_001389588.1 2772835 D 5061 CDS An01g11790 4977971 complement(join(2773538..2774456,2774509..2775721,2775773..2776541)) II 1 NT_166518.1 Similarity: the ORF shows similarity to several hypothetical peptide synthetases.; Title: similarity to hypothetical acetate--CoA ligase involved in polyketide synthesis pksJ - Bacillus subtilis; See PMID 9384377; See PMID 8344529; uncharacterized protein 2776541 4977971 An01g11790 Aspergillus niger uncharacterized protein XP_001389589.1 2773538 R 5061 CDS An01g11800 4977655 complement(join(2776812..2776921,2776971..2777087,2777135..2777309,2777362..2778249,2778309..2778827)) II 1 NT_166518.1 Catalytic activity: Phenol + NADPH + O(2) <=> catechol + NADP(+) + H(2)O; Title: strong similarity to phenol 2-monooxygenase -Trichosporon beigelii; uncharacterized protein 2778827 4977655 An01g11800 Aspergillus niger uncharacterized protein XP_001389590.1 2776812 R 5061 CDS An01g11810 4977254 complement(join(2779857..2780146,2780200..2780531,2780580..2780976,2781040..2781193)) II 1 NT_166518.1 Catalytic activity: ppe1 of S. pombe catalyses the reaction a phosphoprotein + H(2)O <=> a protein + phosphate.; Remark: a gene disruption (designated delta ppe1) causes cold-sensitive lethality and short, pear-shaped cells.; Similarity: the predicted A. niger protein shows strong similarity to cell shape control protein phosphatase ppe1 from S. pombe and other serine/threonine protein phosphatases.; Title: strong similarity to cell shape control protein phosphatase ppe1p - Schizosaccharomyces pombe; See PMID 8387356; uncharacterized protein 2781193 4977254 An01g11810 Aspergillus niger uncharacterized protein XP_001389591.1 2779857 R 5061 CDS An01g11820 4977413 join(2781617..2781867,2781971..2783417) II 1 NT_166518.1 Title: similarity to hypothetical nucleolar phosphoprotein - Neurospora crassa; uncharacterized protein 2783417 4977413 An01g11820 Aspergillus niger uncharacterized protein XP_059603340.1 2781617 D 5061 CDS An01g11830 84590108 complement(2783926..2784978) II 1 NT_166518.1 Title: weak similarity to protein YIL159w -Saccharomyces cerevisiae; uncharacterized protein 2784978 84590108 An01g11830 Aspergillus niger uncharacterized protein XP_059603341.1 2783926 R 5061 CDS An01g11840 4978502 complement(join(2785886..2786359,2786408..2786727,2786782..2787148)) II 1 NT_166518.1 Title: strong similarity to hypothetical protein encoded by An05g02120 - Aspergillus niger; uncharacterized protein 2787148 4978502 An01g11840 Aspergillus niger uncharacterized protein XP_059603342.1 2785886 R 5061 CDS An01g11850 84590109 join(2788913..2788985,2789017..2789042) II 1 NT_166518.1 hypothetical protein 2789042 84590109 An01g11850 Aspergillus niger hypothetical protein XP_059603343.1 2788913 D 5061 CDS An01g11860 4978522 join(2789708..2790240,2790897..2790971,2791073..2791347,2791377..2793091,2793210..2793317) II 1 NT_166518.1 Title: similarity to transcription activator Put3 -Saccharomyces cerevisiae; See PMID 9207794; See PMID 2017167; uncharacterized protein 2793317 4978522 An01g11860 Aspergillus niger uncharacterized protein XP_059603344.1 2789708 D 5061 CDS An01g11880 4977431 join(2794959..2795151,2795205..2795358,2795410..2795580,2795636..2795787,2795839..2796407,2796468..>2796864) II 1 NT_166518.1 Function: ordA of A. parasiticus is involved in the conversion of O-methylsterigmatocystin (OMST) to aflatoxin B1.; Remark: a putative frameshift results in an premature STOP codon.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Similarity: the ORF shows strong similarity to several cytochrome P450-type monooxygenases from different species.; Title: strong similarity to O-methylsterigmatocystin oxidoreductase ordA - Aspergillus parasiticus [putative frameshift]; putative frameshift; uncharacterized protein 2796864 4977431 An01g11880 Aspergillus niger uncharacterized protein XP_059603345.1 2794959 D 5061 CDS An01g11890 84590110 join(2798577..2798748,2799083..2799255) II 1 NT_166518.1 hypothetical protein 2799255 84590110 An01g11890 Aspergillus niger hypothetical protein XP_059603346.1 2798577 D 5061 CDS An01g11900 4977623 2799550..2800206 II 1 NT_166518.1 Title: weak similarity to protein fragment SEQ ID NO:47715 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 2800206 4977623 An01g11900 Aspergillus niger uncharacterized protein XP_001389599.1 2799550 D 5061 CDS An01g11910 4977245 complement(join(2800544..2802485,2802534..2802643,2802718..2803014,2803078..2803215)) II 1 NT_166518.1 Remark: Fission yeast cut17 is required for chromosome segregasion.; Remark: group of cut proteins consists of mutants in which a portion of the nuclear chromatin is stretched by the elongated spindle but the entire nucleus is not separated.; Remark: similarity to Inhibitor of Apoptosis domain; Title: similarity to protein cut17p -Schizosaccharomyces pombe; See PMID 8395535; See PMID 10910336; uncharacterized protein 2803215 4977245 An01g11910 Aspergillus niger uncharacterized protein XP_001389600.1 2800544 R 5061 CDS An01g11920 4977453 join(2803715..2803729,2803803..2805326) II 1 NT_166518.1 Title: similarity to hypothetical protein SPBC1A4.06c - Schizosaccharomyces pombe; uncharacterized protein 2805326 4977453 An01g11920 Aspergillus niger uncharacterized protein XP_001389601.1 2803715 D 5061 CDS An01g11930 4978018 join(2805774..2805847,2805899..2805960,2806036..2806072,2806187..2807210) II 1 NT_166518.1 Catalytic activity: L-histidinol-phosphate + 2-oxoglutarate <=> 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.; Function: histidinol-phosphate aminotransferase.; Pathway: eighth step in histidine biosynthetic pathway.; Remark: responsive to control of general amino acid biosynthesis.; Title: strong similarity to histidinol-phosphate transaminase his3p - Schizosaccharomyces pombe; uncharacterized protein 2807210 4978018 An01g11930 Aspergillus niger uncharacterized protein XP_059603347.1 2805774 D 5061 CDS An01g11940 4977149 join(2809398..2809716,2809955..2811114) II 1 NT_166518.1 Similarity: the ORF shows weak similarity to chitinase chiA of A. nidulans.; Title: similarity to putative integral membrane protein CAF32121.1/AfA33H4.055c - Aspergillus fumigatus; uncharacterized protein 2811114 4977149 An01g11940 Aspergillus niger uncharacterized protein XP_059603348.1 2809398 D 5061 CDS An01g11950 4977534 complement(join(2811884..2812409,2812481..2812563,2812650..2812748)) II 1 NT_166518.1 Catalytic activity: Nucleoside triphosphate + RNA(n) = Pyrophosphate + RNA(n+1); Remark: DNA-directed RNA polymerase I, II, III 25 KD subunit.; Title: strong similarity to 25 kD subunit of DNA-directed RNA polymerase I,II,III Rpb5 - Saccharomyces cerevisiae; nucleus; See PMID 10841537; uncharacterized protein 2812748 4977534 An01g11950 Aspergillus niger uncharacterized protein XP_001389604.1 2811884 R 5061 CDS An01g11960 4977766 join(2813186..2813314,2813539..2814720,2814773..2814982) II 1 NT_166518.1 Complex: Bfr1 also associates with yeast polyribosomes and mRNP complexes.; Complex: Bfr1 interacts with Bbp1, a component of the spindle pole body.; Remark: Bfr1 protein from S. cerevisiae is a multicopy suppressor of brefeldin A-induced lethality. Bfr1, in addition, partially suppresses the growth and secretion defects of the ER-to-Golgi secretion mutant sec17.; Similarity: the predicted A. niger protein shows strong similarity to Bfr1 protein from S. cerevisiae. stronger similarity is found with the hypothetical protein SPAC458. 02c from S. pombe.; Title: similarity to brefeldin A resistance protein Bfr1 - Saccharomyces cerevisiae; See PMID 11410665; See PMID 8070655; uncharacterized protein 2814982 4977766 An01g11960 Aspergillus niger uncharacterized protein XP_001389605.1 2813186 D 5061 CDS An01g11970 4977986 complement(join(2815795..2816379,2816458..2816911,2816984..2817399)) II 1 NT_166518.1 Function: mixed-linked glucanases are extracellular enzymes able to hydrolyze beta 1,3-1,4-glucans.; Title: strong similarity to mixed-linked glucanase MLG1 - Cochliobolus carbonum; See PMID 9464371; uncharacterized protein 2817399 4977986 An01g11970 Aspergillus niger uncharacterized protein XP_001389606.1 2815795 R 5061 CDS An01g11990 4977599 join(2821431..2821448,2821511..2821834) II 1 NT_166518.1 Title: strong similarity to hypothetical protein CAF32129.1 - Aspergillus fumigatus; uncharacterized protein 2821834 4977599 An01g11990 Aspergillus niger uncharacterized protein XP_001389607.1 2821431 D 5061 CDS An01g12000 4977371 2823872..2825035 II 1 NT_166518.1 Function: dsk1 of S. pombe is a protein kinase, that auto-phosphorylates as well as phosphorylates e. g. myelin basic protein (MBP).; Induction: mitotically arrested S. pombe cells have a several-fold higher kinase activity of dsk1 than that from wild type.; Phenotype: high dosage of dsk1+ strongly delays the G2/M progression of S. pombe cells.; Title: similarity to dis1-suppressing protein kinase dsk1p - Schizosaccharomyces pombe; See PMID 8485317; uncharacterized protein 2825035 4977371 An01g12000 Aspergillus niger uncharacterized protein XP_001389608.1 2823872 D 5061 CDS An01g12010 4977828 complement(join(2828819..2829716,2829772..2830479,2830531..2831195)) II 1 NT_166518.1 Title: weak similarity to phosphoprotein phosphatase PPT - Rattus norvegicus; See PMID 8077208; uncharacterized protein 2831195 4977828 An01g12010 Aspergillus niger uncharacterized protein XP_059603349.1 2828819 R 5061 CDS An01g12020 4977865 complement(join(2831913..2832407,2832475..2833384,2833437..2834170)) II 1 NT_166518.1 Similarity: the ORF shows weak similarity to putative bi-functional transferase/deacetylase of S. coelicolor.; Title: strong similarity to hypothetical protein encoded by An04g09400 - Aspergillus niger; uncharacterized protein 2834170 4977865 An01g12020 Aspergillus niger uncharacterized protein XP_001389610.1 2831913 R 5061 CDS An01g12030 84590111 complement(join(2835534..2835605,2835800..2836093)) II 1 NT_166518.1 Title: strong similarity to hypothetical protein encoded by An01g12040 - Aspergillus niger; uncharacterized protein 2836093 84590111 An01g12030 Aspergillus niger uncharacterized protein XP_059603350.1 2835534 R 5061 CDS An01g12040 84590112 complement(join(2837469..2837900,2837992..2838801)) II 1 NT_166518.1 Similarity: shows similarity to several polyketide synthases and fatty acid synthases; the similarity is restricted to the short-chain alcohol dehydrogenase homology and acyl carrier protein homology domains of polyketide synthases and to the beta-ketoacyl reductase and acyl carrier domains of fatty acid synthases.; Title: similarity to polyketide synthase FUM5 -Gibberella moniliformis; See PMID 10413619; uncharacterized protein 2838801 84590112 An01g12040 Aspergillus niger uncharacterized protein XP_059603351.1 2837469 R 5061 CDS An01g12050 4977421 complement(2839195..2840601) II 1 NT_166518.1 Pathway: trichothecene synthesis.; Remark: Regulation of TRI3 transcription in liquid cultures appeared identical to that of other trichothecene pathway genes.; Remark: TRI3 is an acetyltransferase that converts 15-decalonectrin to calonectrin.; Remark: trichothecenes are sesquiterpenoid mycotoxins and act as protein synthesis inhibitors for eukaryotic organisms.; Title: similarity to 15-decalonectrin 15-O-acetyltransferase TRI3 - Fusarium sporotrichioides; See PMID 8593041; uncharacterized protein 2840601 4977421 An01g12050 Aspergillus niger uncharacterized protein XP_001389613.1 2839195 R 5061 CDS An01g12060 84590113 join(2841290..2841345,2841431..2841698,2841777..2842472,2842605..2842900,2843365..2844139) II 1 NT_166518.1 Function: Pwp2p exists in a proteinaceous complex,possibly associated with the cytoskeleton, where it functions in control of cell growth and separation.; Function: it is required for bud-site selection and cell separation.; Localization: HA-Pwp2p of S. cerevisiae was clustered at multiple points in the cytoplasm, probably associates with the cytoskeleton.; Title: similarity to WD-repeat protein Pwp2 -Saccharomyces cerevisiae; See PMID 8804409; uncharacterized protein 2844139 84590113 An01g12060 Aspergillus niger uncharacterized protein XP_059603352.1 2841290 D 5061 CDS An01g12070 84590114 join(2844963..2844990,2845094..2845220,2845618..2845717) II 1 NT_166518.1 hypothetical protein 2845717 84590114 An01g12070 Aspergillus niger hypothetical protein XP_059603353.1 2844963 D 5061 CDS An01g12080 84590115 join(2846976..2847171,2847254..2847299,2847330..2847372,2847615..2847887) II 1 NT_166518.1 hypothetical protein 2847887 84590115 An01g12080 Aspergillus niger hypothetical protein XP_059603354.1 2846976 D 5061 CDS An01g12090 4977243 join(2849029..2850012,2850052..2850225) II 1 NT_166518.1 Catalytic activity: Nitrile + H2O = a Carboxylate + NH3.; Remark: the Klebsiella ozaenae nitrilase BXN converts the herbicide bromoxynil (3,5-dibromo-4-hydroxybenzonitrile) to 3,5-dibromo-4-hydroxybenzoic acid.; Title: strong similarity to nitrilase BXN -Klebsiella ozaenae; uncharacterized protein 2850225 4977243 An01g12090 Aspergillus niger uncharacterized protein XP_059603355.1 2849029 D 5061 CDS An01g12100 4977092 join(2850460..2850873,2850970..2852808) II 1 NT_166518.1 Remark: The gene is required for conversion of either ferulate or vanillate to protocatechuate in Acinetobacter.; Remark: This protein is similar to vanB, but seems 300 aa to long.; Remark: VanA and VanB form an oxygenative demethylase that converts vanillate to protocatechuate in microorganisms.; Title: similarity to vanillate demethylase vanB -Acinetobacter sp.; cytoplasm; See PMID 10348863; See PMID 10671462; uncharacterized protein 2852808 4977092 An01g12100 Aspergillus niger uncharacterized protein XP_001389618.3 2850460 D 5061 CDS An01g12110 4977248 complement(join(2853325..2853329,2853441..2853463,2853515..2854260,2854300..2854322,2854394..2854619)) II 1 NT_166518.1 Title: similarity to hypothetical protein YLL056c -Saccharomyces cerevisiae; uncharacterized protein 2854619 4977248 An01g12110 Aspergillus niger uncharacterized protein XP_059603356.1 2853325 R 5061 CDS An01g12120 4977457 complement(join(2854968..2856563,2856613..2857007,2857071..2857299)) II 1 NT_166518.1 Title: weak similarity to transcription regulator Rgt - Saccharomyces cerevisiae; uncharacterized protein 2857299 4977457 An01g12120 Aspergillus niger uncharacterized protein XP_001389620.3 2854968 R 5061 CDS An01g12130 4978022 2857474..2859045 II 1 NT_166518.1 Catalytic activity: plant enzyme with EC number EC 2. 3. 1. 144 catalyses benzoyl-CoA + anthranilate <=> CoA + N-benzoylanthranilate.; Remark: catalyzes the synthesis of anthranilate (vitamin L1) involved in plant phytoalexin biosynthesis.; Title: similarity to anthranilate N-benzoyltransferase - Dianthus caryophyllus; See PMID 9426598; uncharacterized protein 2859045 4978022 An01g12130 Aspergillus niger uncharacterized protein XP_001389621.3 2857474 D 5061 CDS An01g12150 4977988 complement(join(2859768..2861095,2861143..2861809,2861856..2861990,2862040..2862135,2862183..2862198,2862246..2862512,2862565..2862867,2862935..2863011,2863067..2863201)) II 1 NT_166518.1 Gene-ID: lacA+; See PMID 1368193; beta-galactosidase lacA-Aspergillus niger 2863201 lacA+ 4977988 lacA+ Aspergillus niger beta-galactosidase lacA-Aspergillus niger XP_001389622.1 2859768 R 5061 CDS An01g12160 84590116 complement(join(2866091..2866099,2866157..2866293,2866383..2866395)) II 1 NT_166518.1 hypothetical protein 2866395 84590116 An01g12160 Aspergillus niger hypothetical protein XP_059603357.1 2866091 R 5061 CDS An01g12170 4978521 join(2866998..2867539,2867611..2868067,2868121..2868228) II 1 NT_166518.1 Catalytic activity: Alcohol + NAD+ = Aldehyde or Ketone + NADH; Pathway: Bile acid biosynthesis; Pathway: Fatty acid metabolism; Pathway: Glycerolipid metabolism; Pathway: Glycolysis / Gluconeogenesis; Pathway: Tyrosine metabolism; Title: strong similarity to alcohol dehydrogenase alcB - Aspergillus nidulans; See PMID 8821658; See PMID 10938850; uncharacterized protein 2868228 4978521 An01g12170 Aspergillus niger uncharacterized protein XP_001389624.1 2866998 D 5061 CDS An01g12180 4977796 complement(join(2868464..2868803,2868862..2869396,2869724..2870973,2871048..2871217,2871316..2871336)) II 1 NT_166518.1 Catalytic activity: S-Adenosyl-L-methionine + tRNA = S-Adenosyl-L-homocysteine + tRNA containing 5-methylcytosine.; Remark: similarity to nucleolar Nop2p.; Remark: similarity to proteins involved in rRNA processing.; Remark: weak similarity to human proliferation associated nucleolar antigen P120.; Title: strong similarity to tRNA (cytosine-5-)-methyltransferase Ncl1 - Saccharomyces cerevisiae; nucleus; See PMID 9767141; See PMID 10445884; uncharacterized protein 2871336 4977796 An01g12180 Aspergillus niger uncharacterized protein XP_059603358.1 2868464 R 5061 CDS An01g12190 4977016 join(2871730..2871818,2871874..2872293,2872327..2872397,2872471..2873358,2873459..2873760) II 1 NT_166518.1 Function: MCT3 of H. sapiens is a proton-linked monocarboxylate transporter, that was shown to facilitate cellular import of lactate and pyruvate.; Title: similarity to monocarboxylate transporter MCT3 - Homo sapiens; See PMID 9425115; See PMID 10493836; See PMID 10510291; uncharacterized protein 2873760 4977016 An01g12190 Aspergillus niger uncharacterized protein XP_059603359.1 2871730 D 5061 CDS An01g12200 4977823 join(2875062..2875122,2875206..2875303,2875394..2875639) II 1 NT_166518.1 Title: similarity to hypothetical protein F10B6.29 -Arabidopsis thaliana; uncharacterized protein 2875639 4977823 An01g12200 Aspergillus niger uncharacterized protein XP_001389627.1 2875062 D 5061 CDS An01g12210 4977948 complement(join(2876002..2876392,2876448..2877142,2877207..2877284,2877340..2877465,2877519..2877668)) II 1 NT_166518.1 Function: in Neurospora crassa the beta chain of the mitochondrial processing peptidase and the core I protein of ubiquinol--cytochrome-c reductase are identical.; Function: the protein is bifunctional and participates both in protein processing and electron transport.; Title: strong similarity to core protein I of ubiquinol--cytochrome-c reductase beta-MPP - Neurospora crassa; localisation:mitochondrion; uncharacterized protein 2877668 4977948 An01g12210 Aspergillus niger uncharacterized protein XP_001389628.1 2876002 R 5061 CDS An01g12220 4978014 complement(2878122..2879093) II 1 NT_166518.1 Pathway: galactose metabolism.; Similarity: shows much higher similarity to yet probable fungal UDPglucose 4-epimerases.; Title: similarity to protein SEQ ID NO:52 from patent WO200111033-A2 - Haemophilus influenzae; uncharacterized protein 2879093 4978014 An01g12220 Aspergillus niger uncharacterized protein XP_001389629.1 2878122 R 5061 CDS An01g12230 4977801 complement(join(2879790..2880500,2880569..2880714,2880952..2881036)) II 1 NT_166518.1 Function: it is associated with snoRNA and required for 35S rRNA processing and methylation.; Function: it is involved in cleavage of 33S precursor rRNA at A1 site to yield 32S rRNA.; Function: it is involved in cleavage of 35S precursor rRNA at A0 site to yield 33S rRNA.; Function: protein of S. cerevisiae is involved in cleavage of 32S precursor rRNA at A2 site to yield 20S and 27SA2 precursors.; Title: strong similarity to nucleolar protein Nop1 -Saccharomyces cerevisiae; nucleus; uncharacterized protein 2881036 4977801 An01g12230 Aspergillus niger uncharacterized protein XP_001389630.1 2879790 R 5061 CDS An01g12240 4977274 complement(join(2881666..2882160,2882240..2882506)) II 1 NT_166518.1 Title: strong similarity to hypothetical protein CAC28784.2 - Neurospora crassa; uncharacterized protein 2882506 4977274 An01g12240 Aspergillus niger uncharacterized protein XP_001389631.3 2881666 R 5061 CDS An01g12250 4978180 join(2886023..2886118,2886524..2886663,2886710..2886772,2886878..2886908,2887081..2887204,2887257..2887623,2887682..2888096,2888151..2888300) II 1 NT_166518.1 Remark: ORF might be questionable at the carboxyterminus.; hypothetical protein 2888300 4978180 An01g12250 Aspergillus niger hypothetical protein XP_001389632.3 2886023 D 5061 CDS An01g12260 84590117 complement(join(2889424..2889753,2889946..2890151,2890340..2890344,2890400..2890452)) II 1 NT_166518.1 Similarity: blast hits result from repetitive sequences.; hypothetical protein 2890452 84590117 An01g12260 Aspergillus niger hypothetical protein XP_059603360.1 2889424 R 5061 CDS An01g12270 4977398 2891639..2893723 II 1 NT_166518.1 Similarity: shows only partial similarity to fungal hypothetical protein and is probably not an integral membrane protein.; Title: similarity to hypothetical membrane protein YPL277c - Saccharomyces cerevisiae; uncharacterized protein 2893723 4977398 An01g12270 Aspergillus niger uncharacterized protein XP_001389634.1 2891639 D 5061 CDS An01g12290 4977780 complement(join(2895039..2896172,2896222..2897069,2897121..2897288,2897356..2897485)) II 1 NT_166518.1 Similarity: shows similarity to homeodomain repressor proteins in the family of Drosophila Cut.; Title: similarity to CCAAT displacement protein CASP - Homo sapiens; See PMID 9332351; uncharacterized protein 2897485 4977780 An01g12290 Aspergillus niger uncharacterized protein XP_001389635.1 2895039 R 5061 CDS An01g12300 4977754 join(2898354..2898510,2898563..2901117,2901162..2902070) II 1 NT_166518.1 Function: TRAP-1 can distinguish activated forms of the receptor from wild-type receptor in the absence of TGFbeta and may potentially have a functional role in TGFbeta signaling.; Similarity: shows only partial similarity at the carboxyterminus.; Title: similarity to TGF beta receptor associated protein-1 TRAP-1 - Homo sapiens; uncharacterized protein 2902070 4977754 An01g12300 Aspergillus niger uncharacterized protein XP_001389636.1 2898354 D 5061 CDS An01g12310 4978318 complement(join(2902178..2902448,2902522..2903003,2903093..2903329)) II 1 NT_166518.1 Catalytic activity: hydroxyquinol 1,2-dioxygenase of A. sp. was a novel dioxygenase that catalyzed both the intradiol and extradiol cleavage of catechol.; Cofactor: iron.; Remark: when hydroxyquinol was used as a substrate,the purified enzyme of A. sp. showed 6. 8-fold activity of that for catechol.; Title: similarity to hydroxyquinol 1,2-dioxygenase BAA82713.1 - Arthrobacter sp.; See PMID 10380628; uncharacterized protein 2903329 4978318 An01g12310 Aspergillus niger uncharacterized protein XP_001389637.1 2902178 R 5061 CDS An01g12320 4977551 complement(join(2904020..2905323,2905381..2905996)) II 1 NT_166518.1 Function: might be involved in transcriptional regulation.; Similarity: contains a fungal Zn(2)-Cys(6) binuclear cluster and shows weak similarity to proteins containing the same domain.; Title: strong similarity to possible transcription factor CAF32142.1 - Aspergillus fumigatus; uncharacterized protein 2905996 4977551 An01g12320 Aspergillus niger uncharacterized protein XP_001389638.1 2904020 R 5061 CDS An01g12330 4977137 join(2908736..2908946,2909005..2909076,2909126..2909253) II 1 NT_166518.1 Complex: purified human LSm proteins form a heteromer that is stable even in the absence of RNA and exhibits a doughnut shape under the electron microscope,with striking similarity to the Sm core RNP structure.; Function: the purified LSm heteromer binds specifically to U6 snRNA and it facilitates the formation of U4/U6 RNA duplices in vitro, suggesting that it may play a role in U4/U6 snRNP formation.; Title: similarity to U6 snRNA-associated Sm-like protein LSm7 - Homo sapiens; nucleus; See PMID 10523320; uncharacterized protein 2909253 4977137 An01g12330 Aspergillus niger uncharacterized protein XP_001389639.1 2908736 D 5061 CDS An01g12340 4977605 2909934..>2910239 II 1 NT_166518.1 Remark: truncated ORF due to contig border.; hypothetical protein [truncated ORF] 2910239 4977605 An01g12340 Aspergillus niger hypothetical protein [truncated ORF] XP_001389641.3 2909934 D 5061 CDS An01g12350 84590118 join(<2910344..2911345,2911438..2911443) II 1 NT_166518.1 Remark: truncated ORF due to contig border.; Similarity: shows weak similarity to proteins containing Leucine Rich Repeats.; Title: similarity to hypothetical protein encoded by An15g02640 - Aspergillus niger [truncated ORF]; uncharacterized protein 2911443 84590118 An01g12350 Aspergillus niger uncharacterized protein XP_059599788.1 2910344 D 5061 CDS An01g12360 4977167 complement(join(2911915..2912948,2912996..2913151,2913205..2913349,2913400..2913591,2913700..2913806,2913857..2914061)) II 1 NT_166518.1 Function: pan3 of S. cerevisiae is involved in cell wall biogenesis and architecture.; Similarity: similarity is restricted to carboxyterminus.; Title: similarity to component of the Pab1p-dependent poly(A) ribonuclease Pan3 - Saccharomyces cerevisiae; See PMID 8816488; See PMID 9774670; uncharacterized protein 2914061 4977167 An01g12360 Aspergillus niger uncharacterized protein XP_001389642.3 2911915 R 5061 CDS An01g12370 4977267 join(2915280..2915414,2915446..2916888) II 1 NT_166518.1 Title: similarity to hypothetical protein SPCC285.11 - Schizosaccharomyces pombe; uncharacterized protein 2916888 4977267 An01g12370 Aspergillus niger uncharacterized protein XP_059599789.1 2915280 D 5061 CDS An01g12380 4977469 join(2919391..2921256,2921317..2922246,2922301..2922613,2922667..2924177) II 1 NT_166518.1 Function: multidrug resistance.; Similarity: shows strong similarity to several fungal ABC-transporter.; Title: strong similarity to ATP-binding cassette transporter PMR1 - Penicillium digitatum; plasma membrane; See PMID 9758830; uncharacterized protein 2924177 4977469 An01g12380 Aspergillus niger uncharacterized protein XP_001389644.1 2919391 D 5061 CDS An01g12390 4977885 complement(2925204..2927063) II 1 NT_166518.1 Title: similarity to repressed by TUP1 protein 2 RBT2 - Candida albicans; See PMID 10790384; uncharacterized protein 2927063 4977885 An01g12390 Aspergillus niger uncharacterized protein XP_001389645.1 2925204 R 5061 CDS An01g12395 84590119 join(2928484..2928606,2928891..2929169) II 1 NT_166518.1 hypothetical protein 2929169 84590119 An01g12395 Aspergillus niger hypothetical protein XP_059599790.1 2928484 D 5061 CDS An01g12400 4977012 complement(join(2929476..2929925,2930042..2930257,2930350..2930481)) II 1 NT_166518.1 Title: strong similarity to 3-oxoacyl-(acyl-carrier-protein) reductase fabG - Bacillus subtilis; See PMID 8759840; uncharacterized protein 2930481 4977012 An01g12400 Aspergillus niger uncharacterized protein XP_001389647.1 2929476 R 5061 CDS An01g12410 4977426 join(2931969..2932102,2932228..2933531,2933582..2933904,2933958..2934416) II 1 NT_166518.1 Similarity: to some transcription factors.; Title: similarity to regulator protein qutA -Aspergillus nidulans; uncharacterized protein 2934416 4977426 An01g12410 Aspergillus niger uncharacterized protein XP_001389648.1 2931969 D 5061 CDS An01g12420 4978491 join(2936133..2936135,2936465..2936678,2936872..2937059,2937128..2937277) II 1 NT_166518.1 Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L17 - Rattus norvegicus; cytoplasm; See PMID 2211664; 60S ribosomal protein uL22 2937277 4978491 An01g12420 Aspergillus niger 60S ribosomal protein uL22 XP_001389649.1 2936133 D 5061 CDS An01g12430 4977752 join(2938786..2938822,2938888..2938952,2939018..2939050,2939148..2939531,2939598..2940310,2940397..2940512,2940551..2940554,2940596..2940670,2940763..2940784) II 1 NT_166518.1 Title: strong similarity to hypothetical protein CAF32157.1 - Neurospora crassa; uncharacterized protein 2940784 4977752 An01g12430 Aspergillus niger uncharacterized protein XP_059599791.1 2938786 D 5061 CDS An01g12440 4978054 complement(2940977..2941870) II 1 NT_166518.1 Remark: similarities correspond to multiple S-repeats.; Title: similarity to hypothetical protein BAA13766.1 - Schizosaccharomyces pombe; uncharacterized protein 2941870 4978054 An01g12440 Aspergillus niger uncharacterized protein XP_001389651.1 2940977 R 5061 CDS An01g12450 4977765 complement(join(2945014..2947622,2947672..2947888)) II 1 NT_166518.1 Title: strong similarity to hypothetical glucan beta-1,3 exoglucanase exgS - Aspergillus phoenicis; uncharacterized protein 2947888 4977765 An01g12450 Aspergillus niger uncharacterized protein XP_001389652.3 2945014 R 5061 CDS An01g12460 4977394 complement(join(2950974..2951421,2951517..2951902,2951998..2952471)) II 1 NT_166518.1 Title: similarity to hypothetical valine--pyruvate transaminase DR1030 - Deinococcus radiodurans; uncharacterized protein 2952471 4977394 An01g12460 Aspergillus niger uncharacterized protein XP_001389653.1 2950974 R 5061 CDS An01g12470 4977806 join(2957490..2958831,2958901..2959337) II 1 NT_166518.1 Title: similarity to hypothetical Atu related protein - Neurospora crassa; uncharacterized protein 2959337 4977806 An01g12470 Aspergillus niger uncharacterized protein XP_059599792.1 2957490 D 5061 CDS An01g12480 4977916 2961386..2964703 II 1 NT_166518.1 Title: similarity to hypothetical ankyrin-like cytoskeletal-structural protein - Drosophila melanogaster; uncharacterized protein 2964703 4977916 An01g12480 Aspergillus niger uncharacterized protein XP_001389655.3 2961386 D 5061 CDS An01g12490 84590120 2965662..2967344 II 1 NT_166518.1 Similarity: the ORF shows similarity to NADH dehydrogenase (complex I) as well as others not involved in respiration (1. 6. 99. 3).; Title: similarity to 64 kD NADH dehydrogenase ndh64 - Neurospora crassa; See PMID 10482790; uncharacterized protein 2967344 84590120 An01g12490 Aspergillus niger uncharacterized protein XP_059599793.1 2965662 D 5061 CDS An01g12500 4977195 complement(join(2967494..2967657,2967743..2969042,2969096..2969389)) II 1 NT_166518.1 Catalytic activity: A monocarboxylic acid amide + H(2)O = a monocarboxylate + NH(3).; Title: strong similarity to acetamidase amdS -Aspergillus oryzae; uncharacterized protein 2969389 4977195 An01g12500 Aspergillus niger uncharacterized protein XP_001389657.1 2967494 R 5061 CDS An01g12520 4977280 complement(join(2975511..2976237,2976292..2976407)) II 1 NT_166518.1 Title: strong similarity to beta-ketoacyl reductase rhlG - Pseudomonas aeruginosa; uncharacterized protein 2976407 4977280 An01g12520 Aspergillus niger uncharacterized protein XP_001389658.1 2975511 R 5061 CDS An01g12530 4977786 join(2977135..2977179,2977237..2977710,2977776..2977889) II 1 NT_166518.1 Catalytic activity: O2. - + O2. - + 2 H+ = O2 + H2O2.; Title: strong similarity to manganese superoxide dismutase - Penicillium chrysogenum; uncharacterized protein 2977889 4977786 An01g12530 Aspergillus niger uncharacterized protein XP_001389659.3 2977135 D 5061 CDS An01g12540 84590121 join(2978431..2978743,2978794..2978867) II 1 NT_166518.1 Title: weak similarity to hypothetical protein YPL158c - Saccharomyces cerevisiae; uncharacterized protein 2978867 84590121 An01g12540 Aspergillus niger uncharacterized protein XP_059599794.1 2978431 D 5061 CDS An01g12550 4977321 complement(join(2979236..2979496,2979549..2980829)) II 1 NT_166518.1 Catalytic activity: hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2.; Pathway: glycoprotein biosynthesis.; Remark: A. saitoi msdS enzyme has activity with methyl-2-O-alpha-d-mannopyranosyl alpha-D-mannopyranoside at pH 5. 0, while no activity was determined with methyl-3-O-alpha-D-mannopyranosyl alpha-D-mannopyranoside or methyl-6-O-alpha-D-mannopyranosyl alpha-D-mannopyranoside. The substrate specificity of the enzyme was analysed by using pyridylaminated (PA)-oligomannose-type sugar chains, Man9-6(GlcNAc)2-PA (Man is mannose; GlcNAc is N-acetylglucosamine). The enzyme hydrolysed Man8GlcNAc2-PA (type 'M8A') fastest, and 'M6C' Manalpha1-3[Manalpha1-2Manalpha1-3(Manalpha1-6) Manalpha1-6]Manbeta1-4GlcNAcbeta1-4GlcNAc-PA slowest, among the PA-sugar chains.; Remark: Aspergillus saitoi is a synonym for Aspergillus phoenicis.; Remark: strong similarity to A. niger ESTs: an_3639,an_2055, an_2131, an_2995.; Similarity: belongs to the glycosyl hydrolase family 47.; Title: strong similarity to mannosyl-oligosaccharide 1,2-alpha-mannosidase msdS - Aspergillus saitoi; See PMID 8519794; See PMID 10215597; uncharacterized protein 2980829 4977321 An01g12550 Aspergillus niger uncharacterized protein XP_001389661.1 2979236 R 5061 CDS An01g12560 84590122 join(2981464..2981588,2981636..2981729,2981776..2981887,2982018..2982334) II 1 NT_166518.1 hypothetical protein 2982334 84590122 An01g12560 Aspergillus niger hypothetical protein XP_059599795.1 2981464 D 5061 CDS An01g12570 4977013 join(2983205..2984048,2984097..2985653,2985709..2985908) II 1 NT_166518.1 Catalytic activity: L-histidinol + 2 NAD+ = L-histidine + 2 NADH.; Pathway: histidine metabolism.; Remark: his-3 of N. crassa is a mutifunctional enzyme with the following enzymatic activities: phosphoribosyl-AMP cyclohydrolase (EC 3. 5. 4. 19) / phosphoribosyl-ATP pyrophosphatase (EC 3. 6. 1. 31) / histidinol dehydrogenase (EC 1. 1. 1. 23).; Similarity: belongs to the histidinol dehydrogenases.; Title: strong similarity to histidinol dehydrogenase his-3 - Neurospora crassa; See PMID 2529437; See PMID 2530448; See PMID 3005109; uncharacterized protein 2985908 4977013 An01g12570 Aspergillus niger uncharacterized protein XP_001389663.1 2983205 D 5061 CDS An01g12580 4977088 complement(join(2986104..2986898,2986979..2987074)) II 1 NT_166518.1 Title: similarity to protein fragment SEQ ID NO:21284 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 2987074 4977088 An01g12580 Aspergillus niger uncharacterized protein XP_001389664.1 2986104 R 5061 CDS An01g12590 4977929 join(2987535..2987685,2987777..2988042) II 1 NT_166518.1 Similarity: shows also similarity to EST l3g02a1. r1 from Aspergillus nidulans.; Title: similarity to hypothetical protein 5C2.160 -Neurospora crassa; uncharacterized protein 2988042 4977929 An01g12590 Aspergillus niger uncharacterized protein XP_001389665.3 2987535 D 5061 CDS An01g12600 4977287 complement(2988475..2989419) II 1 NT_166518.1 Remark: TAF17 is broadly, but not universally,required for transcription in yeast, TAF17 depletion and TAF130 depletion each disrupt TFIID integrity yet cause different transcriptional consequences, suggesting that the widespread influence of TAF17 might not be due solely to its function in TFIID.; Remark: alternative name is YMR236w.; Remark: the homologues of this ORF are 50 % shorter.; Similarity: to human transcription factor TFIID.; Title: strong similarity to subunit of transcription initiation factor TFIID Taf17 - Saccharomyces cerevisiae; nucleus; See PMID 8962109; See PMID 10747053; uncharacterized protein 2989419 4977287 An01g12600 Aspergillus niger uncharacterized protein XP_001389666.1 2988475 R 5061 CDS An01g12610 4978200 complement(join(2989990..2990887,2990935..2991715,2991882..2992173,2992231..2992301,2992359..2992467)) II 1 NT_166518.1 Remark: disruption of the yeast genomic SMP2 gene resulted in a respiration-deficient phenotype, although the cells retained mitochondrial DNA, and showed increased stability of pSR1 like the original smp2 mutant. The function of the Smp2 protein in plasmid maintenance is independent of respiration.; Title: strong similarity to plasmid maintenance,respiration and cell proliferation protein Smp2 -Saccharomyces cerevisiae; See PMID 8437575; uncharacterized protein 2992467 4978200 An01g12610 Aspergillus niger uncharacterized protein XP_059599796.1 2989990 R 5061 CDS An01g12620 4977185 join(2993318..2993361,2993426..2993619,2993677..2994695,2994751..2996697) II 1 NT_166518.1 Title: similarity to hypothetical protein 5C2.150 -Neurospora crassa; uncharacterized protein 2996697 4977185 An01g12620 Aspergillus niger uncharacterized protein XP_059599797.1 2993318 D 5061 CDS An01g12630 4978003 join(2997100..2997113,2997167..2997256,2997384..2997515,2997570..2997614,2997691..2997866,2997931..2998019,2998070..2998174,2998270..2998464) II 1 NT_166518.1 Remark: similarity to Arabidopsis thaliana protein fragment SEQ ID NO: 61882 patent EP1033405-A2.; Title: strong similarity to hypothetical protein BAB27240.1 - Mus musculus; uncharacterized protein 2998464 4978003 An01g12630 Aspergillus niger uncharacterized protein XP_059599798.1 2997100 D 5061 CDS An01g12640 4977876 complement(2998608..2999414) II 1 NT_166518.1 Title: strong similarity to hypothetical protein EAA65635.1 - Aspergillus nidulans; uncharacterized protein 2999414 4977876 An01g12640 Aspergillus niger uncharacterized protein XP_001389670.1 2998608 R 5061 CDS An01g12660 84590123 join(3001242..3001335,3001433..3001740,3001905..3002051,3002327..3002464) II 1 NT_166518.1 hypothetical protein 3002464 84590123 An01g12660 Aspergillus niger hypothetical protein XP_059599799.1 3001242 D 5061 CDS An01g12670 84590124 complement(join(3002818..3002841,3002905..3003240)) II 1 NT_166518.1 hypothetical protein 3003240 84590124 An01g12670 Aspergillus niger hypothetical protein XP_059599800.1 3002818 R 5061 CDS An01g12680 84590125 complement(join(3004933..3005004,3005097..3005178,3005373..3005570,3005849..3006079,3006248..3006349,3006421..3006495,3006634..3006662)) II 1 NT_166518.1 Title: weak similarity to DNA-binding protein 5E5 -Rattus norvegicus; See PMID 8537300; uncharacterized protein 3006662 84590125 An01g12680 Aspergillus niger uncharacterized protein XP_059599801.1 3004933 R 5061 CDS An01g12690 4977434 join(3006852..3007042,3007197..3008082) II 1 NT_166518.1 Title: strong similarity to hypothetical protein CAD21381.1 - Neurospora crassa; uncharacterized protein 3008082 4977434 An01g12690 Aspergillus niger uncharacterized protein XP_059599802.1 3006852 D 5061 CDS An01g12700 4977882 complement(join(3009067..3010156,3010215..3010355,3010416..3010504,3010564..3010625,3010678..3010747)) II 1 NT_166518.1 Function: the H. sapiens RBQ-3 preferentially binds to underphosphorylated pRB.; Title: similarity to retinoblastoma protein binding protein RBQ-3 - Homo sapiens; See PMID 7558034; uncharacterized protein 3010747 4977882 An01g12700 Aspergillus niger uncharacterized protein XP_001389675.1 3009067 R 5061 CDS An01g12710 4977424 join(3011558..3011686,3011760..3011916,3011985..3012055,3012116..3016986,3017043..3017058) II 1 NT_166518.1 Catalytic activity: n nucleoside triphosphate = n pyrophosphate + rna(n).; Function: RNA polymerase II catalyzes transcription of mRNA and U1-U5 snRNA.; Remark: RNA polymerase II consists of about 12 to 15 different subunits.; Title: strong similarity to largest subunit of DNA-directed RNA polymerase II rpb1p - Schizosaccharomyces pombe; nucleus; uncharacterized protein 3017058 4977424 An01g12710 Aspergillus niger uncharacterized protein XP_001389676.1 3011558 D 5061 CDS An01g12720 4977844 join(3017909..3017951,3018085..3018159,3018230..3020181) II 1 NT_166518.1 Similarity: patentmatch against tumour suppressor TSA305 protein Y17750 Patentprot.; Title: similarity to tumour suppressor protein TSA305 from patent WO9928457-A1 - Homo sapiens; uncharacterized protein 3020181 4977844 An01g12720 Aspergillus niger uncharacterized protein XP_059599803.1 3017909 D 5061 CDS An01g12730 4977361 join(3020927..3021520,3021610..3021720) II 1 NT_166518.1 Similarity: similarities correspond to multiple T-and P-repeats.; Title: similarity to hypothetical protein EAA65640.1 - Aspergillus nidulans; uncharacterized protein 3021720 4977361 An01g12730 Aspergillus niger uncharacterized protein XP_059599804.1 3020927 D 5061 CDS An01g12740 4977579 complement(join(3022122..3023950,3024033..3024119,3024190..3024517)) II 1 NT_166518.1 Function: p40 and Rab9 presumably act together to drive the process of transport vesicle docking.; Remark: the H. sapiens p40 gene product binds to Rab9 GTP, required for the transport of mannose 6-phosphate receptors from endosomes to the trans-Golgi network.; Title: similarity to Rab9 effector p40 - Homo sapiens; See PMID 9230071; uncharacterized protein 3024517 4977579 An01g12740 Aspergillus niger uncharacterized protein XP_001389679.1 3022122 R 5061 CDS An01g12750 4977542 3025109..3027085 II 1 NT_166518.1 Function: the H. sapiens CDC20 protein directly binds to anaphase-promoting complex during mitosis and G1,and activate its cyclin ubiquitination activity.; Title: strong similarity to cell cycle protein CDC20 - Homo sapiens; nucleus; See PMID 9811605; See PMID 10793135; See PMID 9734353; uncharacterized protein 3027085 4977542 An01g12750 Aspergillus niger uncharacterized protein XP_059599805.1 3025109 D 5061 CDS An01g12760 4977448 complement(join(3027418..3028537,3028595..3029262,3029315..3029382,3029504..3029577,3029638..3029773,3029836..3029917)) II 1 NT_166518.1 Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus niger; See PMID 9197408; uncharacterized protein 3029917 4977448 An01g12760 Aspergillus niger uncharacterized protein XP_059599806.1 3027418 R 5061 CDS An01g12770 4977300 join(3031774..3031791,3031946..3032047,3032410..3033152,3033315..3033500,3033557..3033596) II 1 NT_166518.1 Remark: Functional assays establish that H. sapiens TFIIA has no apparent role in basal transcription but plays an important role in activation of transcription.; Remark: H. sapiens TFIIA can be an integral component of the preinitiation complex.; Remark: the gene for human protein TFIIA alpha encodes a fusion protein of the two subunits p35 and p19.; Title: strong similarity to large subunit of transcription initation factor TFIIA p35/p19 - Homo sapiens; nucleus; uncharacterized protein 3033596 4977300 An01g12770 Aspergillus niger uncharacterized protein XP_059599807.1 3031774 D 5061 CDS An01g12780 4978509 complement(join(3035469..3035783,3035831..3036893,3036985..3037634)) II 1 NT_166518.1 Function: S. cerevisiae Sfp1p regulates the expression of gene products involved in the G2/M transition during the mitotic cell cycle and the DNA-damage response,for example does overexpression of Sfp1p induce the expression of Pds1p, which is known to regulate the G2 checkpoint.; Function: the S. cerevisiae homolog Sfp1p acts as a repressor of the G2/M transition, both in the normal cell cycle and in the G2 checkpoint pathway.; Localization: S. cerevisiae Sfp1p is a nuclear protein with two Cys2His2 zinc-finger domains commonly found in transcription factors.; Title: strong similarity to split zinc finger protein 1 Sfp1 - Saccharomyces cerevisiae; nucleus; uncharacterized protein 3037634 4978509 An01g12780 Aspergillus niger uncharacterized protein XP_001389683.1 3035469 R 5061 CDS An01g12790 84590126 complement(join(3039579..3039745,3040077..3040092)) II 1 NT_166518.1 hypothetical protein 3040092 84590126 An01g12790 Aspergillus niger hypothetical protein XP_059599808.1 3039579 R 5061 CDS An01g12800 4977817 join(3042055..3042281,3042342..3044276,3044334..3044418) II 1 NT_166518.1 Title: strong similarity to hypothetical conserved protein SPAC16.04 - Schizosaccharomyces pombe; uncharacterized protein 3044418 4977817 An01g12800 Aspergillus niger uncharacterized protein XP_001389685.1 3042055 D 5061 CDS An01g12810 4977727 join(3044886..3044910,3044983..3045032,3045078..3045188,3045239..3045342,3045414..3045792) II 1 NT_166518.1 Remark: the systematic name of the matching S. cerevisia protein is YKL065c.; Similarity: the ORF shows strong similarity to EST SEQ ID NO:6241 of patent WO200056762-A2 from Aspergillus oryzae.; Title: similarity to BAX-associated protein fragment SEQ ID NO:242 from patent WO200264766-A2 - Saccharomyces cerevisiae; uncharacterized protein 3045792 4977727 An01g12810 Aspergillus niger uncharacterized protein XP_059599809.1 3044886 D 5061 CDS An01g12820 4977585 complement(3047504..3048811) II 1 NT_166518.1 Function: mdm12 from S. pombe is required for mitochondrial inheritance.; Localization: mdm12 is an integral component of the outer mitochondrial membrane.; Similarity: the ORF shows strong similarity to expressed sequence tag seq id no:6793 of patent WO200056762-A2 from Aspergillus oryzae.; Title: strong similarity to mitochondrial inheritance component mdm12p - Schizosaccharomyces pombe; localisation:mitochondrion; uncharacterized protein 3048811 4977585 An01g12820 Aspergillus niger uncharacterized protein XP_001389687.1 3047504 R 5061 CDS An01g12830 84590127 join(3052130..3052184,3052265..3052496,3052651..3052701,3052968..3053051,3053152..3053238,3053326..3053407) II 1 NT_166518.1 hypothetical protein 3053407 84590127 An01g12830 Aspergillus niger hypothetical protein XP_059599810.1 3052130 D 5061 CDS An01g12840 84590128 join(3054478..3054764,3054924..3055551) II 1 NT_166518.1 hypothetical protein 3055551 84590128 An01g12840 Aspergillus niger hypothetical protein XP_059599811.1 3054478 D 5061 CDS An01g12850 84590129 3056094..3056303 II 1 NT_166518.1 Title: strong similarity to EST an_3045 -Aspergillus niger; uncharacterized protein 3056303 84590129 An01g12850 Aspergillus niger uncharacterized protein XP_059599812.1 3056094 D 5061 CDS An01g12860 84590130 complement(join(3057231..3057248,3057313..3057344,3057460..3057527,3057569..3057699)) II 1 NT_166518.1 hypothetical protein 3057699 84590130 An01g12860 Aspergillus niger hypothetical protein XP_059599813.1 3057231 R 5061 CDS An01g12880 84590131 complement(join(3060061..3060264,3060314..3060408,3060488..3060593)) II 1 NT_166518.1 hypothetical protein 3060593 84590131 An01g12880 Aspergillus niger hypothetical protein XP_059599814.1 3060061 R 5061 CDS An01g12890 84590132 join(3060822..3060883,3061233..3061361,3061415..3061907) II 1 NT_166518.1 hypothetical protein 3061907 84590132 An01g12890 Aspergillus niger hypothetical protein XP_059599815.1 3060822 D 5061 CDS An01g12910 4977963 complement(join(3063979..3065961,3066016..3066157,3066242..3067329)) II 1 NT_166518.1 Title: strong similarity to hypothetical protein kinase Kin3 - Saccharomyces cerevisiae; uncharacterized protein 3067329 4977963 An01g12910 Aspergillus niger uncharacterized protein XP_059599816.1 3063979 R 5061 CDS An01g12920 84590133 join(3067916..3067922,3068182..3068256,3068540..3068628,3068726..3068830,3068935..3069000,3069245..3069417,3069722..3069856,3070245..3070350) II 1 NT_166518.1 hypothetical protein 3070350 84590133 An01g12920 Aspergillus niger hypothetical protein XP_059599817.1 3067916 D 5061 CDS An01g12940 4977562 complement(join(3073638..3073678,3073861..3074727,3074781..3075414)) II 1 NT_166518.1 Title: weak similarity to hypothetical protein CAC17479.1 - Homo sapiens; uncharacterized protein 3075414 4977562 An01g12940 Aspergillus niger uncharacterized protein XP_059599818.1 3073638 R 5061 CDS An01g12950 4977440 3076067..3076888 II 1 NT_166518.1 Title: similarity to hypothetical protein PA0544 -Pseudomonas aeruginosa; uncharacterized protein 3076888 4977440 An01g12950 Aspergillus niger uncharacterized protein XP_001389697.1 3076067 D 5061 CDS An01g12960 4977347 join(3077290..3077387,3077497..3078345,3078459..3078825) II 1 NT_166518.1 Catalytic activity: H. sapiens homolog ACADSB activity goes toward the short branched chain acyl-CoA derivatives ((S)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA), as well as toward the short straight chain acyl-CoAs (butyryl-CoA and hexanoyl-CoA).; Function: The acyl-CoA dehydrogenases (ACDs) are a family of mitochondrial enzymes that oxidize straight chain or branched chain acyl-CoAs in the metabolism of fatty acids or branched chain amino acids.; Title: strong similarity to short/branched chain specific acyl-CoA dehydrogenase precursor ACADSB - Homo sapiens; localisation:mitochondrion; uncharacterized protein 3078825 4977347 An01g12960 Aspergillus niger uncharacterized protein XP_059599819.1 3077290 D 5061 CDS An01g12970 4977336 complement(join(3081242..3081798,3081882..3082185)) II 1 NT_166518.1 Similarity: the ORF shows strong similarity to expressed sequence tag seq id no:6160 of patent WO200056762-A2 from Aspergillus oryzae.; Title: similarity to hypothetical protein T24H10.2 -Caenorhabditis elegans; uncharacterized protein 3082185 4977336 An01g12970 Aspergillus niger uncharacterized protein XP_001389699.1 3081242 R 5061 CDS An01g12980 84590134 join(3083430..3083573,3083685..3083867,3083959..3084006,3084054..3084458) II 1 NT_166518.1 hypothetical protein 3084458 84590134 An01g12980 Aspergillus niger hypothetical protein XP_059599820.1 3083430 D 5061 CDS An01g12990 4977964 join(3085922..3085977,3086308..3086392,3086522..3087916) II 1 NT_166518.1 Title: strong similarity to hypothetical membrane protein YJL091c - Saccharomyces cerevisiae; uncharacterized protein 3087916 4977964 An01g12990 Aspergillus niger uncharacterized protein XP_001389701.3 3085922 D 5061 CDS An01g13000 4977629 join(3088190..3088314,3088394..3088965,3089030..3090150) II 1 NT_166518.1 Function: the heterotrimeric Thermus thermophilus asp-tRNAasn amidotransferase also generates gln-tRNAgln.; Similarity: bears strong sequence similarity to amidase superfamily.; Similarity: the ORF shows strong similarity to expressed sequence tag seq id no:4067 of patent WO200056762-A2 from Aspergillus niger.; Title: strong similarity to glu/asp-tRNA amidotransferase subunit A gatA - Thermus thermophilus; See PMID 10913601; uncharacterized protein 3090150 4977629 An01g13000 Aspergillus niger uncharacterized protein XP_001389702.1 3088190 D 5061 CDS An01g13010 4977692 complement(join(3090587..3092068,3092305..3092403)) II 1 NT_166518.1 Catalytic activity: nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.; Function: the C. albicans homolog PDE1 complements a S. cerevisiae PDEase-deficient mutant. It belongs to the cAMP phosphodiesterases class-II and hydrolyses both cAMP and cGMP.; Remark: C. albicans PDE1 shares a putative protein kinase A (PKA) phosphorylation site with S. cerevisiae PDE1, suggesting a possible regulation by PKA-dependend phosphorylation.; Repression: C. albicans PDE1 is only moderately inhibited by millimolar concentrations of standard PDEase inhibitors.; Title: strong similarity to cyclic nucleotide phosphodiesterase PDE1 - Candida albicans; uncharacterized protein 3092403 4977692 An01g13010 Aspergillus niger uncharacterized protein XP_001389703.1 3090587 R 5061 CDS An01g13020 84590135 join(3092691..3092768,3092886..3093147,3093213..3093220,3093265..3093552) II 1 NT_166518.1 hypothetical protein 3093552 84590135 An01g13020 Aspergillus niger hypothetical protein XP_059599821.1 3092691 D 5061 CDS An01g13030 4978370 complement(join(3094519..3095282,3095359..3095664,3095764..3096202)) II 1 NT_166518.1 Similarity: the ORF shows strong similarity to expressed sequence tag seq id no:5871 of patent WO200056762-A2 from Aspergillus oryzae.; Title: strong similarity to hypothetical protein 68B2.90 - Neurospora crassa; uncharacterized protein 3096202 4978370 An01g13030 Aspergillus niger uncharacterized protein XP_001389705.1 3094519 R 5061 CDS An01g13040 4977372 join(3097110..3097203,3097303..3098684) II 1 NT_166518.1 Catalytic activity: H. sapiens PEPD hydrolyses Xaa-|-Pro dipeptides, also acts on aminoacyl-hydroxyproline analogs, but shows no action on Pro-|-Pro.; Function: the human homolog PEPD is a proline specific metallo-peptidases.; Remark: prolidase (peptidase D) deficiency upsets skin healing and facilitates the occurrence of chronic cutaneous ulcerations.; Title: strong similarity to prolidase PEPD from patent JP02104286-A - Homo sapiens; cytoplasm; uncharacterized protein 3098684 4977372 An01g13040 Aspergillus niger uncharacterized protein XP_059599822.1 3097110 D 5061 CDS An01g13050 84590136 complement(join(3100715..3100733,3100792..3101037,3101168..3101244)) II 1 NT_166518.1 hypothetical protein 3101244 84590136 An01g13050 Aspergillus niger hypothetical protein XP_059599823.1 3100715 R 5061 CDS An01g13060 4977119 join(3102232..3102557,3102686..3102920) II 1 NT_166518.1 Title: strong similarity to EST an_2136 -Aspergillus niger; uncharacterized protein 3102920 4977119 An01g13060 Aspergillus niger uncharacterized protein XP_059599824.1 3102232 D 5061 CDS An01g13070 4977456 join(3103964..3103993,3104051..3104135,3104223..3104449,3104533..3105100,3105300..3106190,3106274..3106434) II 1 NT_166518.1 Complex: S. cerevisiae Sec63p is subunit of the ER translocon.; Function: S. cerevisiae Sec63p is the functional signal recognition particle receptor of the ER protein translocation machinery (translocon) which is responsible for translocation of nascent secretory proteins across the ER membrane and also patricipates in the retrograde proteasome/ubiquitin dependent ER degradation.; Remark: former name Npl1p of S. cerevisiae homolog Sec63p is obsolete.; Title: strong similarity to signal recognition particle receptor Sec63 - Saccharomyces cerevisiae; uncharacterized protein 3106434 4977456 An01g13070 Aspergillus niger uncharacterized protein XP_059599825.1 3103964 D 5061 CDS An01g13080 4977560 complement(join(3107945..3108677,3108767..3108864,3108959..3109162)) II 1 NT_166518.1 Function: the S. pombe homolog ntf1 is a transcription factor involved in regulating nmt1+ expression.; Similarity: S. pombe ntf1 shares substantial homology with a family of Cys6 zinc finger-containing transcription factors typified by GAL4 from S. cerevisiae.; Similarity: the ORF is shorter than nft1 of S. pombe (344 compared to 706 amino acids). The two proteins show a local N-terminal similarity over a stretch of about 100 amino acids.; Title: similarity to thiamin repressible genes regulatory protein ntf1p - Schizosaccharomyces pombe; uncharacterized protein 3109162 4977560 An01g13080 Aspergillus niger uncharacterized protein XP_001389710.1 3107945 R 5061 CDS An01g13090 84590137 complement(join(3110766..3110865,3111365..3111472,3111546..3111639,3111755..3111800,3111903..3112007,3112084..3112261,3112370..3112428,3112548..3112678,3112761..3113001)) II 1 NT_166518.1 hypothetical protein 3113001 84590137 An01g13090 Aspergillus niger hypothetical protein XP_059599826.1 3110766 R 5061 CDS An01g13100 4977930 complement(join(3114043..3114292,3114354..3120744,3120870..3121032)) II 1 NT_166518.1 Similarity: the ORF shows strong similarity to expressed sequence tag an_3084 from Aspergillus niger.; Title: strong similarity to hypothetical protein AAN61518.1 - Caenorhabditis elegans; uncharacterized protein 3121032 4977930 An01g13100 Aspergillus niger uncharacterized protein XP_001389712.3 3114043 R 5061 CDS An01g13110 84590138 complement(join(3121477..3121837,3121912..3121954,3122001..3122210,3122324..3122363)) II 1 NT_166518.1 hypothetical protein 3122363 84590138 An01g13110 Aspergillus niger hypothetical protein XP_059599827.1 3121477 R 5061 CDS An01g13120 4978344 complement(join(3122913..3123044,3123146..3123226,3123304..3123449,3123504..3123520,3123576..3123686,3123749..3123807)) II 1 NT_166518.1 Function: Arl2 interacts with the tubulin-specific chaperone protein known as cofactor D by downregulating the tubulin GAP activity of C, D, and E, and inhibits the binding of D to native tubulin in vitro.; Function: Cofactors C, D, and E assemble the alpha/beta- tubulin heterodimer and also interact with native tubulin, stimulating it to hydrolyze GTP and thus acting together as a beta-tubulin GTPase activating protein (GAP).; Remark: the ADP ribosylation factor-like proteins (Arls) are a family of small monomeric G proteins.; Title: strong similarity to ADP-ribosylation factor-like 2 protein ARL2 - Mus musculus; See PMID 10831612; uncharacterized protein 3123807 4978344 An01g13120 Aspergillus niger uncharacterized protein XP_001389714.1 3122913 R 5061 CDS An01g13130 4977439 join(3124494..3125115,3125238..3126897,3126970..3127024) II 1 NT_166518.1 Function: PTC is a glutamine synthase inhibitor, a herbicide and a component of the antibiotic phosphinotricyl-alanyl-alanine (PTT).; Similarity: shows only partial similarity to patented protein because it is much larger.; Title: weak similarity to phosphinothricin-resistance protein from patent EP0290986 -Alcaligenes faecalis; uncharacterized protein 3127024 4977439 An01g13130 Aspergillus niger uncharacterized protein XP_001389715.3 3124494 D 5061 CDS An01g13150 4977606 join(3127912..3129687,3129773..3130471) II 1 NT_166518.1 Function: enzyme of S. cerevisiae is involved in ribosom assembly.; Similarity: belongs to the 'DEAD' box family helicase.; Similarity: shows also strong similarity to hypothetical protein from S. pombe.; Title: strong similarity to ATP dependent RNA helicase Drs1 - Saccharomyces cerevisiae; nucleus; See PMID 1454790; See PMID 8247005; uncharacterized protein 3130471 4977606 An01g13150 Aspergillus niger uncharacterized protein XP_059599828.1 3127912 D 5061 CDS An01g13160 4977667 join(3131351..3131358,3131483..3131627,3131707..3133278,3133346..3133501) II 1 NT_166518.1 Catalytic activity: 3-carboxy-3-hydroxy-4-methylpentanoate + CoA = acetyl-CoA + 3-methyl-2-oxobutanoate + H2O.; Function: catalyzes the condensation of acetyl-CoA and 2-oxoisovalerate to form 2-isopropylmalate.; Localization: mitochondrial and cytoplasmic.; Pathway: first step in leucine biosynthesis.; Remark: a single nuclear gene produces two forms by use of alternative initiation codons in the same reading frame.; Similarity: belongs to the alpha-ipm synthetase/homocitrate synthase family.; Title: strong similarity to alpha-isopropylmalate synthase Leu4 - Saccharomyces cerevisiae; uncharacterized protein 3133501 4977667 An01g13160 Aspergillus niger uncharacterized protein XP_001389717.1 3131351 D 5061 CDS An01g13170 4977770 complement(join(3134486..3135383,3135439..3136042,3136098..3136325,3136366..3139612)) II 1 NT_166518.1 Function: CPS1 product is described as peptide synthetase-like protein.; Similarity: similar to S. pombe hypothetical protein: SwissProt Accession Number Q10250, S. cerevisiae probable membrane protein YOR093c: PIR Accession Number S61654, S. verticillus bleomycin peptide synthetase BlmVI encoded by GenBank Accession Number AF210249, M. xanthus saframycin Mx1 synthetase SafB: PIR Accession Number T1855; similar to Pfam domain PF00501; Title: strong similarity to hypothetical peptide synthase-like protein CPS1 - Cochliobolus heterostrophus; uncharacterized protein 3139612 4977770 An01g13170 Aspergillus niger uncharacterized protein XP_059605908.1 3134486 R 5061 CDS An01g13180 84590139 complement(join(3140460..3140680,3140761..3140905,3140968..3141123,3141240..3141317,3141667..3141956,3142529..3142581,3143138..3143217)) II 1 NT_166518.1 Similarity: shows only partial similarity to the human protein.; Title: weak similarity to serine-threonine kinase STK9 - Homo sapiens; uncharacterized protein 3143217 84590139 An01g13180 Aspergillus niger uncharacterized protein XP_059605909.1 3140460 R 5061 CDS An01g13190 4977113 join(3143398..3143543,3143766..3143949,3144056..3144373) II 1 NT_166518.1 Complex: ribosomal protein S5. e of S. cerevisiae is a part of the ribosome.; Function: ribosomal protein S5. e of S. cerevisiae is involved in protein biosynthesis.; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S5.e - Saccharomyces cerevisiae; cytoplasm; 40S ribosomal protein uS7 3144373 4977113 An01g13190 Aspergillus niger 40S ribosomal protein uS7 XP_001389720.1 3143398 D 5061 CDS An01g13200 4977305 join(3144977..3145023,3145116..3145151,3145231..3145518,3145582..3147448) II 1 NT_166518.1 Function: pharmaceutical compositions comprising FLEXHT can be used to treat diseases or conditions associated with altered expression of functional FLEXHT.; Function: the polynucleotide sequences of the patent can be used to express the protein sequences.; Function: the proteins and polynucleotides of the patent can be used to diagnose and treat disorders.; Similarity: shows stronger similarity to several hypothetical protein from S. cerevisiae, S. pombe, D. melanogaster, etc.; Title: similarity to FLEXHT-10 from patent WO200070047-A2 - Homo sapiens; uncharacterized protein 3147448 4977305 An01g13200 Aspergillus niger uncharacterized protein XP_001389721.1 3144977 D 5061 CDS An01g13210 4977301 3148057..3148791 II 1 NT_166518.1 Similarity: shows only partial similarity to spd1.; Title: weak similarity to S phase inhibitor spd1p -Schizosaccharomyces pombe; uncharacterized protein 3148791 4977301 An01g13210 Aspergillus niger uncharacterized protein XP_001389722.1 3148057 D 5061 CDS An01g13220 4977397 complement(3149492..3152494) II 1 NT_166518.1 Function: neither heat shock nor a range of other stimuli, including hydrogen peroxide, cobalt chloride,2-deoxyglucose, or tunicamycin, led to its expression,suggesting selectivity for production of ORP150 in response to oxygen deprivation, i. e. it was an oxygen-regulated protein (ORP150).; Title: strong similarity to 150 kDa oxygen regulated protein ORP150 - Rattus norvegicus; See PMID 8617779; uncharacterized protein 3152494 4977397 An01g13220 Aspergillus niger uncharacterized protein XP_001389723.1 3149492 R 5061 CDS An01g13230 4977450 complement(join(3153113..3153374,3153432..3153620,3153669..3153967,3154027..3154465,3154550..3154752,3154821..3154892)) II 1 NT_166518.1 Function: the patented sequences (DNA database) can be used to treat and diagnose cancer and cell proliferative, autoimmune/inflammatory, vesicle trafficking,neurological, cardiovascular, cell motility, reproductive and muscle disorders.; Similarity: shows higher similarity to hypothetical proteins.; Title: similarity to cytoskeleton-associated protein 4 from patent WO200017355-A2 - Homo sapiens; uncharacterized protein 3154892 4977450 An01g13230 Aspergillus niger uncharacterized protein XP_059605910.1 3153113 R 5061 CDS An01g13240 4977481 3155513..3157498 II 1 NT_166518.1 Title: similarity to hypothetical protein CAE75736.1 - Neurospora crassa; uncharacterized protein 3157498 4977481 An01g13240 Aspergillus niger uncharacterized protein XP_001389725.1 3155513 D 5061 CDS An01g13250 4977689 complement(join(3158263..3159829,3159897..3160064,3160124..3160193,3160263..3160297,3160374..3160495)) II 1 NT_166518.1 Title: similarity to hypothetical protein YKL047w -Saccharomyces cerevisiae; uncharacterized protein 3160495 4977689 An01g13250 Aspergillus niger uncharacterized protein XP_059605911.1 3158263 R 5061 CDS An01g13260 4977726 join(3161022..3161238,3161319..3161482,3161568..3161802,3161871..3161953) II 1 NT_166518.1 Function: EBP is suggested to be the first structurally characterized member of a family of high affinity microsomal drug acceptor proteins carrying so called sigma-binding sites.; Function: EBP shared structural features with pro-and eukaryotic drug transport proteins.; Function: the emopamil-binding protein (EBP) acts as a high affinity acceptor for several antiischemic drugs and thus represents a potential common molecular target for antiischemic drug action.; Title: strong similarity to emopamil-binding protein - Cavia porcellus; See PMID 7706302; uncharacterized protein 3161953 4977726 An01g13260 Aspergillus niger uncharacterized protein XP_001389727.1 3161022 D 5061 CDS An01g13270 4977852 join(3162483..3162582,3162894..3163029,3163361..3163391,3163517..3168766) II 1 NT_166518.1 Complex: the SRm160/300 splicing coactivator,consists of the serine/arginine (SR)-related nuclear matrix protein of 160 kDa and a 300-kDa nuclear matrix antigen.; Function: it functions in splicing by promoting critical interactions between splicing factors bound to pre-mRNA, including snRNPs and SR family proteins.; Similarity: shows only partial similarity to several protein having repetitive sequences.; Title: similarity to splicing coactivator subunit SRm300 - Homo sapiens; See PMID 10668804; See PMID 11004489; uncharacterized protein 3168766 4977852 An01g13270 Aspergillus niger uncharacterized protein XP_001389728.3 3162483 D 5061 CDS An01g13280 4977926 complement(join(3169516..3172222,3172291..3172580,3172643..3172669)) II 1 NT_166518.1 Complex: human Rad54B, like human Rad54 (hRad54),associates with human Rad51 (hRad51) through their NH(2)-terminal domains.; Function: human Rad54B is involved in mitotic and meiotic recombination and repair.; Remark: human RAD54B is highly homologous to mammalian RAD54.; Remark: in contrast to Rad54, whose association with Rad51 is induced by ionizing radiation, Rad54B associates with Rad51 constitutively in immunoprecipitation experiments.; Similarity: the predicted A. niger protein shows strong similarity to huamn RAD54B, which belongs to the SNF2 superfamily, with sequence motifs similar to those in DNA and RNA helicases.; Title: strong similarity to RAD54B - Homo sapiens; See PMID 9409819; See PMID 9409820; See PMID 9335591; uncharacterized protein 3172669 4977926 An01g13280 Aspergillus niger uncharacterized protein XP_001389729.3 3169516 R 5061 CDS An01g13290 4977992 complement(join(3173022..3173778,3173828..3174320,3174375..3174489,3174626..3174808)) II 1 NT_166518.1 Title: strong similarity to choline permease Hnm1 -Saccharomyces cerevisiae; plasma membrane; See PMID 2203793; See PMID 8720066; See PMID 9348664; uncharacterized protein 3174808 4977992 An01g13290 Aspergillus niger uncharacterized protein XP_059605912.1 3173022 R 5061 CDS An01g13300 84590140 join(3175536..3175598,3175693..3175845,3175993..3176093,3176226..3176403) II 1 NT_166518.1 hypothetical protein 3176403 84590140 An01g13300 Aspergillus niger hypothetical protein XP_059605913.1 3175536 D 5061 CDS An01g13310 84590141 join(3176804..3176924,3177061..3177158,3177445..3177522,3177618..3177692,3177794..3177901,3178310..3178396,3179027..3179176,3179341..3179547) II 1 NT_166518.1 hypothetical protein 3179547 84590141 An01g13310 Aspergillus niger hypothetical protein XP_059605914.1 3176804 D 5061 CDS An01g13320 4977949 join(3179798..3179842,3179959..3180209,3180263..3180396,3180455..3181122) II 1 NT_166518.1 Function: the product of M. grisea pathogenicity gene pth11 is not required for appressorium morphogenesis but is involved in host surface recognition.; Similarity: shows only partial similarity to protein of M. grisea.; Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529; uncharacterized protein 3181122 4977949 An01g13320 Aspergillus niger uncharacterized protein XP_059605915.1 3179798 D 5061 CDS An01g13330 84590142 complement(join(3181509..3181619,3181720..3181792,3182036..3182055,3182145..3182220,3182316..3182356,3182427..3182676,3183011..3183064,3183163..3183239,3183670..3183810,3183909..3183936,3184054..3184160)) II 1 NT_166518.1 hypothetical protein 3184160 84590142 An01g13330 Aspergillus niger hypothetical protein XP_059605916.1 3181509 R 5061 CDS An01g13340 4977621 join(3184459..3184555,3184750..3185910,3186011..3186468) II 1 NT_166518.1 Function: the protein of H. pylori demonstrates good protective properties against H. pylori, which has been strongly implicated in chronic active gastritis and peptic ulcer disease.; Remark: the protein of H. pylori was found as hit in patent database against DNA.; Similarity: shows partial similarity to several dehydrogenases and deacetylases.; Similarity: shows similarity at the carboxyterminal only, protein of patent is much shorter.; Title: similarity to 35kDa antigenic protein from patent WO200029432-A1 - Helicobacter pylori; uncharacterized protein 3186468 4977621 An01g13340 Aspergillus niger uncharacterized protein XP_001389735.1 3184459 D 5061 CDS An01g13350 4977283 complement(3186916..3189705) II 1 NT_166518.1 Function: protein of S. cerevisiae binds to damaged proteins and actively participates in an emergent rescue function as a molecular chaperone.; Function: protein of S. cerevisiae is important for reactivation of mRNA splicing after heat shock, assists in the repair of the splicing apparatus. .; Function: protein of S. cerevisiae is involved in barotolerance that is temperature dependent.; Function: protein of S. cerevisiae is most likely a disaggregator of proteins during hydrostatic pressure stress.; Function: protein of S. cerevisiae is required for thermotolerance ethanol and other stresses.; Function: protein of S. cerevisiae is required in normal amounts for [psi+] phenotype and for conversion of [psi-] to [psi+].; Similarity: shows strong similarity to endopeptidase Clp of several species.; Title: strong similarity to heat shock protein Hsp104 - Saccharomyces cerevisiae; cytoplasm; See PMID 9369220; See PMID 9391130; See PMID 9703962; uncharacterized protein 3189705 4977283 An01g13350 Aspergillus niger uncharacterized protein XP_001389736.1 3186916 R 5061 CDS An01g13360 84590143 complement(join(3190264..3190373,3190394..3190640,3190943..3191079,3191129..3191212,3191311..3191372,3191453..3191478)) II 1 NT_166518.1 Similarity: shows only partial similarity to Su(UR)ES of D. melanogaster.; Title: weak similarity to supressor of underreplication Su(UR)ES - Drosophila melanogaster; See PMID 11033777; uncharacterized protein 3191478 84590143 An01g13360 Aspergillus niger uncharacterized protein XP_059605917.1 3190264 R 5061 CDS An01g13370 4977203 join(3192045..3192107,3192216..3192398,3192795..3193640,3193713..3193856) II 1 NT_166518.1 Similarity: shows similarity to N-terminus only of several N-methyltransferase of Nicotiana spec.; Title: weak similarity to putrescine N-methyltransferase NsPMT1 - Nicotiana sylvestris; uncharacterized protein 3193856 4977203 An01g13370 Aspergillus niger uncharacterized protein XP_059605918.1 3192045 D 5061 CDS An01g13390 4977508 complement(join(3195015..3195871,3195941..3196208)) II 1 NT_166518.1 Title: similarity to hypothetical protein CAD21062.1 - Neurospora crassa; uncharacterized protein 3196208 4977508 An01g13390 Aspergillus niger uncharacterized protein XP_059605919.1 3195015 R 5061 CDS An01g13400 4977566 join(3197257..3197274,3197340..3197474,3197597..3197664,3197773..3197965) II 1 NT_166518.1 Function: the S. cerevisiae Gim3 protein (prefoldin 4 homolog) binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. It binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.; Remark: alternate names for S. cerevisiae Gim3: Pfd4 or YNL153C.; Title: strong similarity to homolog of the prefoldin subunit 4 Gim3 - Saccharomyces cerevisiae; cytoplasm; See PMID 9463374; uncharacterized protein 3197965 4977566 An01g13400 Aspergillus niger uncharacterized protein XP_001389740.1 3197257 D 5061 CDS An01g13410 4977639 complement(join(3198482..3199595,3199651..3200426,3200479..3200580,3200651..3201121)) II 1 NT_166518.1 Function: the cutinase transcription factor 1 CTF1alpha from Fusarium solani positively acts in vivo by binding selectively to palindrome 2 of the cutinase gene promoter. This has been shown in the heterolog S. cerevisiae system.; Similarity: the ORF encoded protein shows strong similarity to the hypothetical transcription factor B14D6. 340 from Neurospora crassa.; Title: similarity to cutinase transcription factor alpha CTF1a - Fusarium solani; nucleus; See PMID 9139694; uncharacterized protein 3201121 4977639 An01g13410 Aspergillus niger uncharacterized protein XP_059605920.1 3198482 R 5061 CDS An01g13420 84590144 complement(join(3203329..3203423,3203582..3203679,3203756..3203858,3204274..3204352,3204426..3204534,3204639..3204737,3204805..3204881,3205102..3205238,3205396..3205492)) II 1 NT_166518.1 Title: weak similarity to hypothetical protein CG8621 - Drosophila melanogaster; uncharacterized protein 3205492 84590144 An01g13420 Aspergillus niger uncharacterized protein XP_059605921.1 3203329 R 5061 CDS An01g13430 84590145 complement(join(3205840..3205897,3205989..3206318,3206410..3206483,3206542..3206697,3206790..3206897)) II 1 NT_166518.1 Title: weak similarity to desaturase homologue from patent WO9846764-A1 - Schizochytrium sp.; uncharacterized protein 3206897 84590145 An01g13430 Aspergillus niger uncharacterized protein XP_059605922.1 3205840 R 5061 CDS An01g13440 84590146 join(3207247..3207347,3207528..3207629,3207670..3207783,3207866..3207965,3208068..3208202) II 1 NT_166518.1 Title: weak similarity to hypothetical protein AAF13358.1 - Eufolliculina uhligi; uncharacterized protein 3208202 84590146 An01g13440 Aspergillus niger uncharacterized protein XP_059605923.1 3207247 D 5061 CDS An01g13450 4977895 complement(join(3209946..3210044,3210530..3210748)) II 1 NT_166518.1 Title: similarity to hypothetical protein B9B15.40 -Neurospora crassa; uncharacterized protein 3210748 4977895 An01g13450 Aspergillus niger uncharacterized protein XP_001389745.3 3209946 R 5061 CDS An01g13460 4978021 join(<3211524..3211630,3211726..>3212733) II 1 NT_166518.1 Title: strong similarity to hypothetical protein B9B15.50 - Neurospora crassa; uncharacterized protein 3212733 4978021 An01g13460 Aspergillus niger uncharacterized protein XP_001389746.3 3211524 D 5061 CDS An01g13470 4977467 complement(join(3213679..3213869,3213943..3214124,3214226..3215223)) II 1 NT_166518.1 Title: similarity to topoisomerase II binding protein TopBP from patent JP11075856-A - Homo sapiens; uncharacterized protein 3215223 4977467 An01g13470 Aspergillus niger uncharacterized protein XP_001389747.3 3213679 R 5061 CDS An01g13480 4978182 join(3218479..3218531,3218687..3219175,3219233..3219355,3219434..3219836) II 1 NT_166518.1 Title: strong similarity to protein SEQ ID NO:7805 from patent WO200253728-A2 - Candida albicans; uncharacterized protein 3219836 4978182 An01g13480 Aspergillus niger uncharacterized protein XP_059603361.1 3218479 D 5061 CDS An01g13490 4977482 complement(join(3220456..3221069,3221136..3221553,3221617..3221718)) II 1 NT_166518.1 Catalytic activity: Acyl-CoA + H(2)O <=> CoA + a carboxylate.; Complex: the human acyl-CoA thioesterase II was isolated as an HIV nef-binding protein by yeast two-hybrid system.; Remark: the human acyl-CoA thioesterase II (trembl|HSRNATII_1;Pubmed 10807905) is identical to the hACTE-III protein (pir|JC5644; Pubmed 9299485).; Similarity: human acyl-CoA thioesterase II is homologous to E. coli thioesterase II but to none of the mammalian thioesterases.; Title: strong similarity to thioesterase II hTE -Homo sapiens; See PMID 9299485; See PMID 10807905; uncharacterized protein 3221718 4977482 An01g13490 Aspergillus niger uncharacterized protein XP_059603362.1 3220456 R 5061 CDS An01g13495 84590147 3222164..3222595 II 1 NT_166518.1 hypothetical protein 3222595 84590147 An01g13495 Aspergillus niger hypothetical protein XP_059603363.1 3222164 D 5061 CDS An01g13500 4978000 complement(3223119..3223754) II 1 NT_166518.1 hypothetical protein 3223754 4978000 An01g13500 Aspergillus niger hypothetical protein XP_059603364.1 3223119 R 5061 CDS An01g13510 4977530 join(3224347..3224350,3224492..3225136,3225181..3225766,3225829..3226157,3226213..3226399,3226456..3226834) II 1 NT_166518.1 Function: the Sequence 5 from Patent WO0077222 (S. natalensis) is encodes a protein involved at the biosynthesis of pimaricin.; Remark: Pimaricin is an archetype polyene, important in the food industry as a preservative to prevent mould contamination of foods, produced by Streptomyces natalensis. Polyene macrolides are a class of large macrocyclic polyketides that interact with membrane sterols, having antibiotic activity against fungi but not bacteria.; Title: similarity to protein sequence 5 from patent WO0077222 - Streptomyces natalensis; uncharacterized protein 3226834 4977530 An01g13510 Aspergillus niger uncharacterized protein XP_059603365.1 3224347 D 5061 CDS An01g13520 84590148 join(3227200..3227898,3228018..3228223,3228283..3228724) II 1 NT_166518.1 Similarity: B10H4. 010 from N. crassa shows similarity to cholesterol oxidase.; Title: strong similarity to hypothetical protein B10H4.010 - Neurospora crassa; uncharacterized protein 3228724 84590148 An01g13520 Aspergillus niger uncharacterized protein XP_059603366.1 3227200 D 5061 CDS An01g13530 4977681 3229044..3230252 II 1 NT_166518.1 Function: the S. cerevisiae Gpi8 protein is a transamidase involved in the attachment of GPI-anchors to proteins.; Localization: Gpi8 is a 47 kDa type I membrane glycoprotein residing on the luminal side of the ER membrane.; Remark: alternate name for S. cerevisiae Gpi8: YDR331w.; Similarity: S. cerevisiae Gpi8 belongs to peptidase family C13; also known as the hemoglobinase family.; Title: strong similarity to protein involved in the attachment of GPI-anchors to proteins Gpi8 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 8978684; See PMID 10727241; uncharacterized protein 3230252 4977681 An01g13530 Aspergillus niger uncharacterized protein XP_001389754.1 3229044 D 5061 CDS An01g13540 4977480 join(3231169..3231577,3231692..3231889,3232104..3232351,3232406..3233405,3233559..>3233805) II 1 NT_166518.1 Remark: Sna41 from S. pombe is involved in DNA replication and may play some roles in the regulation of DNA replication by the MCM proteins.; Remark: a putative frameshift results in a premature STOP codon.; Remark: the replication licensing factor limits DNA replication to once in a cell cycle and is thought to contain MCM proteins. the Nda4 protein of Schizosaccharomyces pombe is one of the MCM proteins and is involved in DNA replication.; Similarity: the ORF encoded protein shows also strong similarity to Cdc45 from S. cerevisiae, which is also known to be involved in DNA replication (required for initiation of chromosomal DNA replication).; Title: strong similarity to suppressor of nda4 mutation sna41p - Schizosaccharomyces pombe [putative frameshift]; nucleus; putative frameshift; See PMID 9619628; uncharacterized protein 3233805 4977480 An01g13540 Aspergillus niger uncharacterized protein XP_059603367.1 3231169 D 5061 CDS An01g13550 4977602 join(3234448..3235229,3235304..>3235987) II 1 NT_166518.1 Remark: ORF contains two frameshifts, due to putative sequencing errors.; Title: strong similarity to hypothetical protein AAL60010.1 - Arabidopsis thaliana [putative frameshift]; putative frameshift; uncharacterized protein 3235987 4977602 An01g13550 Aspergillus niger uncharacterized protein XP_059603368.1 3234448 D 5061 CDS An01g13560 4977041 complement(join(3236849..3237050,3237100..3237214,3237258..3237864,3237925..3238136,3238187..>3238232)) II 1 NT_166518.1 Catalytic activity: N ATP + {nucleotide}(M) <=> N diphosphate + {nucleotide}(M+N).; Function: the poly(A) polymerase Pla1 from S. pombe creates the 3' poly(A) tail of mRNA's.; Remark: N-terminally truncated ORF due to the end of contig.; Title: strong similarity to poly(A) polymerase la1p - Schizosaccharomyces pombe [truncated ORF]; nucleus; See PMID 8692700; uncharacterized protein 3238232 4977041 An01g13560 Aspergillus niger uncharacterized protein XP_001389757.3 3236849 R 5061 CDS An01g13570 84590149 complement(join(<3238348..3238399,3238472..3238620)) II 1 NT_166518.1 Catalytic activity: ATP + RNA(n) = pyrophosphate + RNA(n+1).; Remark: C-terminal truncated ORF due to end of contig.; Remark: also acts slowly with CTP. Catalyses template-independent extension of the 3'- and of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment or oligo(A) bearing 3'-OH terminal group.; Title: similarity to poly(A) polymerase pla1p -Schizosaccharomyces pombe [truncated ORF]; See PMID 8692700; uncharacterized protein 3238620 84590149 An01g13570 Aspergillus niger uncharacterized protein XP_059599829.1 3238348 R 5061 CDS An01g13580 4977832 complement(join(3239198..3239280,3239337..3239416,3239465..3239612,3239673..3239782,3239846..3240341,3240418..3240562)) II 1 NT_166518.1 Remark: strong similarity to Streptomyces clavuligerus protein sequence of orfdwn1 patent WO9833896-A2.; Remark: the present sequence represents the protein sequence of a gene specific for 5S clavam biosynthesis from Streptomyces clavuligerus (SC) and which is not essential for 5R clavam biosynthesis.; Title: strong similarity to clavaminate synthase orfdwn1 from patent WO9833896-A2 - Streptomyces clavuligerus; See PMID 10223939; uncharacterized protein 3240562 4977832 An01g13580 Aspergillus niger uncharacterized protein XP_001389759.1 3239198 R 5061 CDS An01g13590 4977804 3241439..3242827 II 1 NT_166518.1 Catalytic activity: N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-glutamate + L-2-aminoadipate 6-semialdehyde + NADPH.; Pathway: lysine biosynthesis.; Remark: the biosynthesis of the essential amino acid lysine in higher fungi and cyanobacteria occurs via the alpha-aminoadipate pathway, which is completely different from the lysine biosynthetic pathway found in plants and bacteria. The penultimate reaction in the alpha-aminoadipate pathway is catalysed by NADPH-dependent saccharopine reductase.; Title: strong similarity to saccharopine reductase LYS3 - Magnaporthe grisea; See PMID 10771443; See PMID 11080625; uncharacterized protein 3242827 4977804 An01g13590 Aspergillus niger uncharacterized protein XP_001389760.1 3241439 D 5061 CDS An01g13600 4977650 complement(join(3244577..3244961,3245025..3245444,3245595..3245734)) II 1 NT_166518.1 Function: the S. cerevisiae Mir1 protein should be involved in the mitochondrial protein import (Pubmed 2170848). Its gene has also been cloned as mitochondrial phosphate transport which is responsible for the transport of phosphate groups from the cytosol to the mitochondrial matrix (Pubmed 1840493).; Remark: alternate name for S. cerevisiae Mir1: YJR077C.; Similarity: the ORF DNA sequence is very strong similar to the EST an_3225 Aspergillus niger.; Title: strong similarity to mitochondrial phosphate transport protein Mir1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 1840493; See PMID 2170848; uncharacterized protein 3245734 4977650 An01g13600 Aspergillus niger uncharacterized protein XP_001389761.1 3244577 R 5061 CDS An01g13610 4977630 join(3247174..3247243,3247313..3247720,3247780..3248369,3248445..3248510,3248558..3248780,3248828..3249165) II 1 NT_166518.1 Function: this alkaline alpha-amylase from Patent WO0060058 catalyzes the endohydrolysis of 1,4-alpha-glucosidic linkages in oligosaccharides and polysaccharides.; Title: strong similarity to unnamed ORF encoding a alkaline alpha-amylase sequence 1 from patent WO0060058 -Bacillus sp.; uncharacterized protein 3249165 4977630 An01g13610 Aspergillus niger uncharacterized protein XP_059599830.1 3247174 D 5061 CDS An01g13620 4977127 complement(join(3249255..3250397,3250467..3250871)) II 1 NT_166518.1 Catalytic activity: ATP + gamma-L-glutamyl-L-cysteine + glycine <=> ADP + phosphate + glutathione.; Pathway: the glutathione synthetase Gsh2 from S. cerevisiae catalyzes the second step of glutathione biosynthesis.; Remark: alternate name for S. cerevisiae Gsh2: YOL049w.; Title: strong similarity to glutathione synthase Gsh2 - Saccharomyces cerevisiae; See PMID 9512666; uncharacterized protein 3250871 4977127 An01g13620 Aspergillus niger uncharacterized protein XP_059599831.1 3249255 R 5061 CDS An01g13630 4977466 3252064..3252849 II 1 NT_166518.1 Title: strong similarity to yaiB from patent FR2807446-A1 - Lactococcus lactis; uncharacterized protein 3252849 4977466 An01g13630 Aspergillus niger uncharacterized protein XP_001389764.1 3252064 D 5061 CDS An01g13640 4977522 join(3254720..3254835,3254932..3254981,3255047..3255382,3255461..3255552,3255612..3255660,3255791..3256789,3256847..3256947,3257002..3257680,3257746..3258452) II 1 NT_166518.1 Function: nirA mediates nitrate induction in Aspergillus nidulans.; Title: similarity to nitrate assimilation regulatory protein nirA - Aspergillus nidulans; See PMID 1922075; uncharacterized protein 3258452 4977522 An01g13640 Aspergillus niger uncharacterized protein XP_001389765.1 3254720 D 5061 CDS An01g13650 4977571 3259180..3261216 II 1 NT_166518.1 Function: the M. pneumoniae HMW1 protein is component of the cytoskeleton-like structure which stabilizes the shape of the wall-less mycoplasma. This cytoskeleton-like network of accessory proteins containing hmw proteins 1 to 5 allows the proper anchoring of cytadhesin proteins in the mycoplasmal membrane at the attachment organelle.; Title: similarity to cytadherence accessory protein HMW1 - Mycoplasma pneumoniae; See PMID 9495768; uncharacterized protein 3261216 4977571 An01g13650 Aspergillus niger uncharacterized protein XP_001389766.3 3259180 D 5061 CDS An01g13660 4978017 join(3262149..3262392,3262474..3262951,3263002..3264070) II 1 NT_166518.1 Catalytic activity: 4 benzenediol + O(2) <=> 4 benzosemiquinone + 2 H(2)O.; Cofactor: Copper.; Function: the laccase I from E. nidulans catalyzes the oxidation of benzendiol to benzosemiquinone by molecular oxygen. Laccases are a group of multi-copper proteins of low specificity acting on both catechol and p-benzenediol, and often acting also on aminophenols and phenylenediamine. Laccase I from E. nidulans is a p-diphenol oxidase which is needed for synthesis of green conidial pigment.; Remark: the 1990 decribed (Pubmed 2192364) yA gene from E. nidulans encodes the previous 1982 purified laccase I enzyme (Pubmed 7050088), which differs from the laccase II enzyme (Pubmed 6341366).; Title: strong similarity to laccase I precursor yA -Aspergillus nidulans; See PMID 7050088; See PMID 2192364; See PMID 2659435; uncharacterized protein 3264070 4978017 An01g13660 Aspergillus niger uncharacterized protein XP_001389767.1 3262149 D 5061 CDS An01g13670 4978060 join(3264536..3264673,3264736..3265085,3265142..3266849,3266901..3267368) II 1 NT_166518.1 Title: strong similarity to hypothetical protein CAF06065.1 - Neurospora crassa; uncharacterized protein 3267368 4978060 An01g13670 Aspergillus niger uncharacterized protein XP_001389768.1 3264536 D 5061 CDS An01g13680 4977240 join(3267934..3267990,3268132..3268232,3268316..3268832) II 1 NT_166518.1 Title: similarity to polypeptide SEQ ID NO:41157 from patent WO200171042-A2 - Drosophila melanogaster; uncharacterized protein 3268832 4977240 An01g13680 Aspergillus niger uncharacterized protein XP_001389769.1 3267934 D 5061 CDS An01g13690 4977059 complement(join(3269059..3269193,3269248..3269484,3269560..3269959,3270022..3270185)) II 1 NT_166518.1 Function: the S. cerevisiae Pas7 protein binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import. For example it is essential for import of 3-oxoacyl-coa thiolase (a PTS2-containing protein) into peroxisomes. It may direct the thiolase to peroxisomes by shuttling between the cytosol and peroxisomal membranes.; Remark: alternate names for S. cerevisiae Pas7: Pex7, Peb1 or YDR142C.; Title: strong similarity to peroxisome targeting signal receptor Pas7 - Saccharomyces cerevisiae; cytoplasm; See PMID 8636211; See PMID 8670791; uncharacterized protein 3270185 4977059 An01g13690 Aspergillus niger uncharacterized protein XP_059599832.1 3269059 R 5061 CDS An01g13700 84590150 join(3271039..3271394,3271446..3272004,3272083..3272463,3272624..3272752,3272904..3273050,3273138..3273538,3273633..3274153,3274216..3274327,3274381..3274641,3274727..3275912,3275989..3276048) II 1 NT_166518.1 Function: the Crz1 protein from S. cerevisiae is a zinc finger transcription factor that acts via the CDRE UAS element (calcineurin-dependent response element). Crz1 is sufficient to confer calcineurin-dependent transcriptional induction of the FKS2 structure gene, which encodes a beta-1,3 glucan synthase.; Remark: alternate names for S. cerevisiae Crz1: Hal8, Tcn1 or YNL027W.; Title: similarity to calcineurin responsive zinc-finger transcription factor Crz1 - Saccharomyces cerevisiae; nucleus; See PMID 9407035; uncharacterized protein 3276048 84590150 An01g13700 Aspergillus niger uncharacterized protein XP_059599833.1 3271039 D 5061 CDS An01g13710 4977578 complement(join(3276057..3276119,3276205..3276358,3276466..3276651,3276740..3276965,3277056..3277697,3277751..3277938,3278001..3278034,3278097..3278317,3278366..3278470,3278528..3279198,3279296..3279513,3279602..3279857)) II 1 NT_166518.1 Protein sequence is in conflict with the conceptual translation; Function: the human 'lodestar' homolog shows similar properties as the original 'lodestar' protein from Drosophila, it displayed a strong double-stranded DNA-dependent ATPase activity that was inhibited by single-stranded DNA and exhibited RNA polymerase II termination activity.; Similarity: the human 'lodestar' homolog belongs to the SWI2/SNF2 protein family of DNA dependent ATPases.; Title: strong similarity to homolog of the lodestar ATPase - Homo sapiens [putative sequencing error]; nucleus; putative sequencing error; See PMID 9748214; uncharacterized protein 3279857 4977578 An01g13710 Aspergillus niger uncharacterized protein XP_059599834.1 3276057 R 5061 CDS An01g13720 4977941 complement(join(3279962..3280047,3280134..3280188,3280296..3280428,3280560..3281272)) II 1 NT_166518.1 Similarity: the ORF shows strong similarity to the A. niger EST an_3546.; Title: strong similarity to hypothetical protein encoded by An12g06470 - Aspergillus niger; uncharacterized protein 3281272 4977941 An01g13720 Aspergillus niger uncharacterized protein XP_059599835.1 3279962 R 5061 CDS An01g13730 84590151 join(3283280..3283412,3283519..3283616,3283713..3284465) II 1 NT_166518.1 Remark: the proeteinsequence shows glutamin arginin rich repeat domain.; Title: strong similarity to hypothetical protein encoded by An01g13710 - Aspergillus niger; uncharacterized protein 3284465 84590151 An01g13730 Aspergillus niger uncharacterized protein XP_059599836.1 3283280 D 5061 CDS An01g13740 4977637 complement(join(3287028..3287811,3288102..3288367)) II 1 NT_166518.1 Title: similarity to hypothetical protein EAA33322.1 - Neurospora crassa; uncharacterized protein 3288367 4977637 An01g13740 Aspergillus niger uncharacterized protein XP_059599837.1 3287028 R 5061 CDS An01g13750 4977767 join(3289222..3290336,3290647..3290695) II 1 NT_166518.1 Title: similarity to hypothetical DNA repair system protein alkB - Xanthomonas axonopodis; uncharacterized protein 3290695 4977767 An01g13750 Aspergillus niger uncharacterized protein XP_001389776.3 3289222 D 5061 CDS An01g13760 84590152 join(3290907..3291058,3291116..3291328,3291592..3291649) II 1 NT_166518.1 Title: weak similarity to hypothetical cytochrome c-type protein NapB precursor PA1173 - Pseudomonas aeruginosa; uncharacterized protein 3291649 84590152 An01g13760 Aspergillus niger uncharacterized protein XP_059599838.1 3290907 D 5061 CDS An01g13770 4977903 complement(join(3291844..3291927,3291981..3292750,3292814..3292908,3292967..3293028)) II 1 NT_166518.1 Similarity: N-terminal to ubiquitin-conjugating enzymes.; Title: weak similarity to crossbronx cbx -Drosophila melanogaster; uncharacterized protein 3293028 4977903 An01g13770 Aspergillus niger uncharacterized protein XP_059599839.1 3291844 R 5061 CDS An01g13780 4977994 complement(join(3293303..3293937,3294022..3294496)) II 1 NT_166518.1 Remark: the protein shows repetitive sequences.; hypothetical protein 3294496 4977994 An01g13780 Aspergillus niger hypothetical protein XP_001389779.1 3293303 R 5061 CDS An01g13790 4978212 complement(3295198..3297747) II 1 NT_166518.1 Function: proteins containing homeobox domains are likely to play an important role in development and most are known to be sequence-specific DNA-binding transcription factors.; Remark: the protein shows only similarity in the DNA-binding homeodomain.; Title: weak similarity to homeodomain protein Prep-1 - Homo sapiens; See PMID 9482739; See PMID 9482740; uncharacterized protein 3297747 4978212 An01g13790 Aspergillus niger uncharacterized protein XP_059599840.1 3295198 R 5061 CDS An01g13810 4977883 join(3300422..3300492,3300546..3300665,3300734..3301007,3301064..3301784,3301838..3303138,3303194..3303347,3303401..3303830,3303885..3304288,3304365..3304606) II 1 NT_166518.1 Catalytic activity: ATP + Urea + CO2 = ADP + Orthophosphate + Urea-1-carboxylate.; Pathway: urea cycle and metabolism of amino groups; nitrogen metabolism.; Remark: DUR1,2 in S. cerevisiae is induced by the presence of allophanate, the last intermediate of the allantoin degradative pathway.; Remark: expression of allantoin pathway genes is subject to induction and nitrogen catabolite repression.; Title: strong similarity to urea amidolyase Dur1 -Saccharomyces cerevisiae; See PMID 1802034; See PMID 1938916; uncharacterized protein 3304606 4977883 An01g13810 Aspergillus niger uncharacterized protein XP_001389781.1 3300422 D 5061 CDS An01g13820 4977878 complement(3304923..3306623) II 1 NT_166518.1 Title: strong similarity to protein sequence SEQ ID NO:18221 from patent EP1074617-A2 - Homo sapiens; uncharacterized protein 3306623 4977878 An01g13820 Aspergillus niger uncharacterized protein XP_001389782.1 3304923 R 5061 CDS An01g13830 4977888 complement(join(3307059..3308011,3308249..3308780)) II 1 NT_166518.1 Title: strong similarity to GTP-binding protein cgtA - Caulobacter crescentus; uncharacterized protein 3308780 4977888 An01g13830 Aspergillus niger uncharacterized protein XP_059599841.1 3307059 R 5061 CDS An01g13850 84590153 complement(join(3313208..3313465,3313496..3313600)) II 1 NT_166518.1 hypothetical protein 3313600 84590153 An01g13850 Aspergillus niger hypothetical protein XP_059599842.1 3313208 R 5061 CDS An01g13860 84590154 join(3316136..3316184,3316324..3316558,3316679..3316718) II 1 NT_166518.1 hypothetical protein 3316718 84590154 An01g13860 Aspergillus niger hypothetical protein XP_059599843.1 3316136 D 5061 CDS An01g13870 84590155 complement(join(3321261..3321410,3321484..3321505,3321555..3321574)) II 1 NT_166518.1 hypothetical protein 3321574 84590155 An01g13870 Aspergillus niger hypothetical protein XP_059599844.1 3321261 R 5061 CDS An01g13880 4977924 join(3323734..3323827,3324124..3325048,3325114..3325927) II 1 NT_166518.1 Remark: resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. this protein functions as a metal-tetracycline/h+ antiporter.; Similarity: belongs to the major facilitator family (also known as the drug resistance translocase family).; Title: similarity to tetracycline resistance protein TetR - Pasteurella multocida; See PMID 8109938; uncharacterized protein 3325927 4977924 An01g13880 Aspergillus niger uncharacterized protein XP_001389787.1 3323734 D 5061 CDS An01g13890 4977803 join(3327880..3330118,3330172..3330224,3330278..3331219) II 1 NT_166518.1 Remark: the uaY gene codes for a transcriptional activator mediating the induction of a number of unlinked genes involved in purine utilization in Aspergillus nidulans.; Similarity: to GAL4 zinc binuclear cluster proteins.; Title: strong similarity to positive regulator of purine utilisation uaY - Aspergillus nidulans; See PMID 7729421; uncharacterized protein 3331219 4977803 An01g13890 Aspergillus niger uncharacterized protein XP_001389788.1 3327880 D 5061 CDS An01g13900 4977539 join(3332914..3334108,3334240..3334315,3334371..3335727) II 1 NT_166518.1 Similarity: to dnaJ molecular chaperones.; Title: similarity to hypothetical protein dnajp -Schizosaccharomyces pombe; uncharacterized protein 3335727 4977539 An01g13900 Aspergillus niger uncharacterized protein XP_059599845.1 3332914 D 5061 CDS An01g13910 4977168 complement(join(3336263..3336577,3336698..3337414)) II 1 NT_166518.1 Remark: ELO1 is a gene involved in the elongation of the fatty acid 14:0 to 16:0.; Remark: synonyms for elo1: YJL196c.; Title: similarity to fatty acid elongation protein Elo1 - Saccharomyces cerevisiae; See PMID 8702485; See PMID 9546663; uncharacterized protein 3337414 4977168 An01g13910 Aspergillus niger uncharacterized protein XP_059599846.1 3336263 R 5061 CDS An01g13920 4977251 join(3338951..3338993,3339102..3339170,3339223..3339674,3339751..3340461) II 1 NT_166518.1 Catalytic activity: GTP + IMP + L-Aspartate = GDP + Orthophosphate + N6-(1,2-Dicarboxyethyl)-AMP.; Pathway: purine metabolism; alanine and aspartate metabolism.; Remark: adenylosuccinate synthetase catalyzes the first committed step in the de novo biosynthesis of AMP,thermodynamically coupling the hydrolysis of GTP to the formation of adenylosuccinate from l-aspartate and IMP.; Title: strong similarity to adenylosuccinate synthase ade2p - Schizosaccharomyces pombe; See PMID 10496970; See PMID 1448066; uncharacterized protein 3340461 4977251 An01g13920 Aspergillus niger uncharacterized protein XP_001389791.1 3338951 D 5061 CDS An01g13930 4978513 join(3341030..3341329,3341565..3341641,3341733..3341852,3341923..3342088) II 1 NT_166518.1 Catalytic activity: succinate + acceptor = fumarate + reduced acceptor; Pathway: citrate cycle (TCA cycle); oxidative phosphorylation; butanoate metabolism; reductive carboxylate cycle (CO2 fixation); electron Transport System, Complex II.; Remark: succinate dehydrogenase (EC 1. 3. 99. 1) is an intrinsic bacterial or inner mitochondrial membrane protein that catalyses the oxidation of succinate and donates electrons to the respiratory chain via quinone acceptors.; Title: similarity to succinate dehydrogenase -Saccharomyces cerevisiae; See PMID 8120006; uncharacterized protein 3342088 4978513 An01g13930 Aspergillus niger uncharacterized protein XP_059599847.1 3341030 D 5061 CDS An01g13940 4977991 complement(3342321..3343181) II 1 NT_166518.1 Function: Maf proteins are a putative inhibitor of septum formation in eukaryotes, bacteria, and archaea.; Similarity: the ORF shows similarity to the N-terminal half of H. sapiens cetylserotonin methytransferase-like protein ASMTL, representing the part of the unique fusion product, which is homologous to the bacterial maf/orfE genes.; Title: strong similarity to septum formation protein maf - Bacillus subtilis; See PMID 8387996; See PMID 9736779; See PMID 10747295; uncharacterized protein 3343181 4977991 An01g13940 Aspergillus niger uncharacterized protein XP_001389793.1 3342321 R 5061 CDS An01g13950 4977792 complement(3343918..3344358) II 1 NT_166518.1 Remark: Mlx act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors.; Remark: the predicted protein shows a basic-helix-loop-helix-leucine zipper motif.; Remark: transcriptional repression by Mad1:Mlx heterodimers is dependent on dimerization, DNA binding, and recruitment of the mSin3A. HDAC corepressor complex.; Title: similarity to MAX-like bHLHZIP protein MLX -Homo sapiens; See PMID 10593926; uncharacterized protein 3344358 4977792 An01g13950 Aspergillus niger uncharacterized protein XP_001389794.1 3343918 R 5061 CDS An01g13960 4977820 join(3345040..3345160,3345224..3345894) II 1 NT_166518.1 Title: weak similarity to nucleolin DNCHNL - Gallus gallus; See PMID 2114180; uncharacterized protein 3345894 4977820 An01g13960 Aspergillus niger uncharacterized protein XP_001389795.1 3345040 D 5061 CDS An01g13970 84590156 complement(join(3346441..3346566,3346619..3346621)) II 1 NT_166518.1 hypothetical protein 3346621 84590156 An01g13970 Aspergillus niger hypothetical protein XP_059599848.1 3346441 R 5061 CDS An01g13980 4977715 join(3348408..3348519,3348723..3348794,3348845..3349932,3349987..3350130) II 1 NT_166518.1 Remark: the homology is only in the C-terminal part of the protein.; Title: weak similarity to exo-alpha-sialidase TCNA -Trypanosoma cruzi; See PMID 1711561; uncharacterized protein 3350130 4977715 An01g13980 Aspergillus niger uncharacterized protein XP_001389797.1 3348408 D 5061 CDS An01g13990 84590157 join(3351192..3351461,3351523..3351849,3351984..3352043) II 1 NT_166518.1 Remark: weak similarity to part of the atropin protein.; hypothetical protein 3352043 84590157 An01g13990 Aspergillus niger hypothetical protein XP_059599849.1 3351192 D 5061 CDS An01g14000 4977996 join(3352628..3352670,3352728..3353103,3353198..3353548,3353602..3353620) II 1 NT_166518.1 Catalytic activity: (3R)-3-Hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-Oxoacyl-[acyl-carrier protein] + NADPH.; Pathway: fatty acid biosynthesis.; Remark: chnA contains to a cyclohexanol oxidation gene cluster.; Remark: exhibits a marked preference for acyl-carrier-protein derivatives over CoA derivatives as substrates.; Title: strong similarity to cyclohexanol dehydrogenase chnA - Acinetobacter sp.; See PMID 10940013; uncharacterized protein 3353620 4977996 An01g14000 Aspergillus niger uncharacterized protein XP_059599850.1 3352628 D 5061 CDS An01g14010 4977636 join(3354700..3354976,3355024..3355498,3355550..3356606) II 1 NT_166518.1 Catalytic activity: 4 Benzenediol + O2 = 4 Benzosemiquinone + 2 H2O.; Remark: laccases are a group of multi-copper proteins of low specificity. Act on both O- and P-quinols,and often acting also on aminophenols and phenylenediamine.; Remark: the semiquinone may react further either enzymically or non- enzymically.; Title: strong similarity to brown 2 protein abr2 -Aspergillus fumigatus; See PMID 10515939; uncharacterized protein 3356606 4977636 An01g14010 Aspergillus niger uncharacterized protein XP_001389800.1 3354700 D 5061 CDS An01g14020 4977634 join(3357308..3358099,3358147..3358290,3358350..3359252) II 1 NT_166518.1 Remark: aflR function is conserved between Aspergillus spp. and that aflR expression is sufficient to activate genes in the ST pathway.; Remark: the protein seems approximately 200 amino acids longer, but there is a wide lenght variety in transcription regulators.; Similarity: to unassigned GAL4-type zinc cluster proteins.; Title: similarity to sterigmatocystin synthesis transcription regulator aflR - Aspergillus nidulans; See PMID 8662194; uncharacterized protein 3359252 4977634 An01g14020 Aspergillus niger uncharacterized protein XP_059599851.1 3357308 D 5061 CDS An01g14030 4977383 3360643..3361716 II 1 NT_166518.1 Remark: there is a small glutamin rich region which maps to many other proteins.; Title: similarity to hypothetical protein CAD21072.1 - Neurospora crassa; uncharacterized protein 3361716 4977383 An01g14030 Aspergillus niger uncharacterized protein XP_001389802.1 3360643 D 5061 CDS An01g14040 4977966 join(3364335..3364366,3364417..3364627,3364683..3366353) II 1 NT_166518.1 Title: weak similarity to finger protein spalt major Dvirsalm - Drosophila virilis; See PMID 7905822; uncharacterized protein 3366353 4977966 An01g14040 Aspergillus niger uncharacterized protein XP_001389803.1 3364335 D 5061 CDS An01g14050 4977346 join(3366885..3367038,3367137..3367482,3367533..3368100,3368153..3368241,3368413..3368884,3368937..3369003,3369060..3369209,3369272..3369660) II 1 NT_166518.1 Remark: APC4 homologues are required for metaphase-to-anaphase transitions during meiosis and mitosis.; Remark: anaphase-promoting complex is composed of eight protein subunits, including APC4.; Title: similarity to anaphase-promoting complex subunit 4 APC4 - Homo sapiens; See PMID 9469815; uncharacterized protein 3369660 4977346 An01g14050 Aspergillus niger uncharacterized protein XP_059599852.1 3366885 D 5061 CDS An01g14060 84590158 join(3370131..3370433,3370476..3370499) II 1 NT_166518.1 hypothetical protein 3370499 84590158 An01g14060 Aspergillus niger hypothetical protein XP_059599853.1 3370131 D 5061 CDS An01g14070 4977957 join(3371225..3371264,3371360..3371418,3371504..3372310,3372378..3373006,3373067..3373283,3373334..3373666,3373722..3373959,3374012..3374120,3374172..3374354,3374390..3374417) II 1 NT_166518.1 Remark: proteins that contain nuclear localization sequences are recognized in the cytoplasm and delivered to the nucleus by the heterodimeric importin complex.; Remark: the S. cerevisiae protein KAP95 is involved in nuclear import; required for the docking of import substrate to the nuclear membrane/pore; identified as an rna1-1 synthetic lethal.; Similarity: to importin beta chains of many organisms; Title: strong similarity to karyopherin beta Kap95 -Saccharomyces cerevisiae; See PMID 9238021; See PMID 10831607; uncharacterized protein 3374417 4977957 An01g14070 Aspergillus niger uncharacterized protein XP_059599854.1 3371225 D 5061 CDS An01g14075 84590159 complement(3374663..3374920) II 1 NT_166518.1 hypothetical protein 3374920 84590159 An01g14075 Aspergillus niger hypothetical protein XP_059599855.1 3374663 R 5061 CDS An01g14080 4977829 join(3375798..3375930,3376210..3376469) II 1 NT_166518.1 Remark: YS24 is part of the small (40S) ribosomal subunit.; Remark: synonyms are S24, YS22, RP50, YP58.; Similarity: YS24 of S. cerevisiae belongs to S8 protein family.; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit Ys24 - Saccharomyces cerevisiae; cytoplasm; See PMID 6814480; See PMID 4000930; 40S ribosomal protein uS8 3376469 4977829 An01g14080 Aspergillus niger 40S ribosomal protein uS8 XP_001389808.1 3375798 D 5061 CDS An01g14090 4978385 join(3376837..3376872,3376960..3377291,3377371..3377964,3378058..3378172) II 1 NT_166518.1 Remark: homology to patent EP0999284; Title: similarity to sequence 13 from patent EP0999284 - Candida albicans; uncharacterized protein 3378172 4978385 An01g14090 Aspergillus niger uncharacterized protein XP_001389809.1 3376837 D 5061 CDS An01g14100 4977484 complement(join(3378370..3379965,3380032..3380295)) II 1 NT_166518.1 Remark: Herp is the first integral membrane protein regulated by the ER stress response pathway. Both the N and C termini face the cytoplasmic side of the ER; this membrane topology makes it unlikely that Herp acts as a molecular chaperone for proteins in the ER.; Title: weak similarity to stress protein Herp - Mus musculus; uncharacterized protein 3380295 4977484 An01g14100 Aspergillus niger uncharacterized protein XP_059599856.1 3378370 R 5061 CDS An01g14110 4977474 3380932..3382572 II 1 NT_166518.1 Catalytic activity: Phosphatidyl-L-serine = Phosphatidylethanolamine + CO2.; Pathway: glycine, serine and threonine metabolism; glycerolipid metabolism; Remark: phosphatidylserine decarboxylase plays a pivotal role in the synthesis of phospholipid by the mitochondria.; Title: strong similarity to phosphatidylserine decarboxylase 1 Psd1 - Saccharomyces cerevisiae; See PMID 8227017; See PMID 8407984; uncharacterized protein 3382572 4977474 An01g14110 Aspergillus niger uncharacterized protein XP_001389811.1 3380932 D 5061 CDS An01g14120 4977529 join(3382906..3383572,3383640..3384469) II 1 NT_166518.1 Catalytic activity: cleavage at Xaa+ bonds in which Xaa carries a hydrophobic, basic or acidic sidechain; Remark: proteasomes are large, multisubunit particles that act as the proteolytic machinery for most regulated intracellular protein breakdown in eukaryotic cells.; Remark: the protein seems approximately 300 aa to long.; Title: similarity to proteasome alpha subunit ProsMA5 - Drosophila melanogaster; See PMID 9409776; See PMID 9647634; uncharacterized protein 3384469 4977529 An01g14120 Aspergillus niger uncharacterized protein XP_001389812.1 3382906 D 5061 CDS An01g14130 4977432 complement(join(3384748..3384980,3385051..3385678,3385748..3385843,3385903..3385971,3386043..3386063,3386137..3386187)) II 1 NT_166518.1 Catalytic activity: 3-Carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-Carboxy-4-methyl-2-oxopentanoate + NADH.; Gene-ID: leu2A; Pathway: valine, leucine and isoleucine biosynthesis; Remark: in A. niger are two highly divergent,differentially regulated, isozymes for beta-isopropylmalate dehydrogenase present.; Remark: the differences in the sequence might be caused by strain variations or sequencing errors.; See PMID 8781173; beta-isopropylmalate dehydrogenase A leu2A-Aspergillus niger 3386187 leu2A 4977432 leu2A Aspergillus niger beta-isopropylmalate dehydrogenase A leu2A-Aspergillus niger XP_001389813.1 3384748 R 5061 CDS An01g14140 4978458 complement(join(3386910..3387227,3387281..3387657,3387715..3387880)) II 1 NT_166518.1 Catalytic activity: CDPdiacylglycerol + myo-Inositol = CMP + Phosphatidyl-1D-myo-inositol.; Pathway: glycerolipid metabolism.; Remark: a splice site was detected upstream of the START codon.; Remark: the CDPdiacylglycerol--inositol 3-phosphatidyltransferase was abundantly expressed in rat brain and kidney.; Title: strong similarity to CDPdiacylglycerol--inositol 3-phosphatidyltransferase -Rattus norvegicus; See PMID 8804431; uncharacterized protein 3387880 4978458 An01g14140 Aspergillus niger uncharacterized protein XP_001389814.1 3386910 R 5061 CDS An01g14160 4977512 complement(join(3388924..3389906,3390033..3390116,3390171..3390612)) II 1 NT_166518.1 Catalytic activity: a phosphoprotein + H(2)O <=> a protein + phosphate.; Function: the protein phosphatase MP2C from Medicago sativa functions as a negative regulator of mitogen activated protein kinase (MAPK) pathways.; Title: similarity to protein phosphatase 2C MP2C -Medicago sativa; See PMID 9465121; See PMID 10571894; uncharacterized protein 3390612 4977512 An01g14160 Aspergillus niger uncharacterized protein XP_059599857.1 3388924 R 5061 CDS An01g14180 4977897 complement(join(3392507..3392765,3392824..3393303,3393367..3393675,3393730..3394394)) II 1 NT_166518.1 Remark: Pad-1 seems to be essential for both asexual and sexual development.; Title: strong similarity to splice factor Pad-1 -Neurospora crassa; See PMID 9578630; See PMID 10801464; uncharacterized protein 3394394 4977897 An01g14180 Aspergillus niger uncharacterized protein XP_001389816.1 3392507 R 5061 CDS An01g14200 4977015 complement(join(3395152..3395305,3395370..3395618,3395673..3396388)) II 1 NT_166518.1 Function: Scs7p is required for the hydroxylation of the very long chain fatty acid in yeast.; Remark: alternate names for the S. cereviseae SCS7 gene: FAH1, YMR272C.; Similarity: the Scs7p gene product from S. cerevisiae contains a cytochrome b5-like domain.; Title: strong similarity to fatty acid hydroxylase Scs7 - Saccharomyces cerevisiae; See PMID 9368039; See PMID 9559540; uncharacterized protein 3396388 4977015 An01g14200 Aspergillus niger uncharacterized protein XP_001389817.1 3395152 R 5061 CDS An01g14210 4978176 join(3399919..3400210,3400271..3401250) II 1 NT_166518.1 Alternative name: Cephalosporium acremonium.; Catalytic activity: orotidine 5'-phosphate <=> UMP + CO(2).; Pathway: the pyr4 gene product of Acremonium chrysogenum catalyzes sixth and last step in the biosynthesis of pyrimidines.; Title: similarity to orotidine-5-phosphate decarboxylase pyr4 - Acremonium chrysogenum; See PMID 2140299; See PMID 2587233; uncharacterized protein 3401250 4978176 An01g14210 Aspergillus niger uncharacterized protein XP_059599858.1 3399919 D 5061 CDS An01g14230 4977669 join(3402656..3403547,3403619..3404316) II 1 NT_166518.1 Title: similarity to hypothetical hydroxyproline-rich glycoprotein like protein CAD21077.1 -Neurospora crassa; uncharacterized protein 3404316 4977669 An01g14230 Aspergillus niger uncharacterized protein XP_001389819.1 3402656 D 5061 CDS An01g14250 4977309 complement(join(3405216..3406128,3406185..3406381,3406438..3406881,3406944..3406946)) II 1 NT_166518.1 Complex: CopD from bovine is the delta subunit of the oligomeric coatamer complex.; Function: the coatomer complex is required for budding from Golgi membranes in Bos taurus.; Function: the coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with golgi non-clathrin-coated vesicles.; Remark: the complex is essential for the retrograde Golgi-to-ER transport of dilysine tagged proteins.; Title: strong similarity to delta subunit of the coatomer delta-coat protein CopD - Bos taurus; cytoplasm; See PMID 8858162; uncharacterized protein 3406946 4977309 An01g14250 Aspergillus niger uncharacterized protein XP_001389820.3 3405216 R 5061 CDS An01g14280 4978041 join(3407400..3408644,3408697..3410103) II 1 NT_166518.1 Similarity: the similarity of the ORF encoded protein to its homologues based mainly on repetitive structures.; Title: weak similarity to hypothetical surface protein AAS - Staphylococcus saprophyticus; uncharacterized protein 3410103 4978041 An01g14280 Aspergillus niger uncharacterized protein XP_001389821.3 3407400 D 5061 CDS An01g14290 4977743 join(3411744..3411946,3412252..3412329,3412579..3412622,3412675..3412700,3412905..3413028,3413099..3413266,3413327..3413618,3413673..3414153) II 1 NT_166518.1 Remark: the Arabidopsis thaliana gene product has the protein id: AAF79266. 1.; Title: strong similarity to hypothetical protein F12K21.21 - Arabidopsis thaliana; uncharacterized protein 3414153 4977743 An01g14290 Aspergillus niger uncharacterized protein XP_059599859.1 3411744 D 5061 CDS An01g14310 4977955 join(3415094..3415304,3415437..3416167,3416224..3418139,3418329..3418497) II 1 NT_166518.1 Function: Sac1p encodes a novel lipid phosphoinositide phosphatase in which specific mutations can cause the sac1 phenotypes by altering the in vivo regulation of the protein.; Function: Sac1p is an important regulator of microsomal ATP transport providing a possible link between inositol phospholipid signaling and ATP-dependent processes in the yeast ER.; Remark: S. cerevisiae sac1 mutants are showing a inositol dependent phenotype.; Remark: Sac1p shares primary sequence homology with a subfamily of cytosolic/peripheral membrane phosphoinositide phosphatases, the synaptojanins which have approximately the same lenght.; Remark: the SAC1 gene product (Sac1p) is an integral membrane protein of the endoplasmic reticulum and the Golgi complex.; Title: strong similarity to lipid phosphoinositide phosphatase Sac1 - Saccharomyces cerevisiae; See PMID 10075922; See PMID 10625610; See PMID 2687291; uncharacterized protein 3418497 4977955 An01g14310 Aspergillus niger uncharacterized protein XP_001389823.3 3415094 D 5061 CDS An01g14330 4978019 join(3419969..3420070,3420320..3422838,3422891..3422900,3422991..3423092) II 1 NT_166518.1 Protein sequence is in conflict with the conceptual translation; Complex: S. cerevisiae Kap104p binds to its substrates Nab2p, Nab4p/Hrp1p and the small GTPase Ran/Gsp1.; Complex: efficient Ran-GTP-mediated substrate release from Kap104p requires RNA, indicating an interaction between Kap104p and RNA.; Function: Kap104p is a S. cerevisiae nuclear import receptor for two essential mRNA-binding proteins, Nab2p and Nab4p/Hrp1p.; Localization: S. cerevisiae Kap104p shuttles its substrate from the cytoplasm into the nucleus and therefore occurs in both cellular compartments.; Remark: the systematic name for S. cerevisiae KAP104 is YBR017c.; Similarity: S. cerevisiae Kap104p belongs to the beta-karyopherin (or importin) family or proteins.; Title: strong similarity to nuclear import receptor Kap104 - Saccharomyces cerevisiae; putative frameshift; See PMID 8849456; See PMID 10506153; uncharacterized protein 3423092 4978019 An01g14330 Aspergillus niger uncharacterized protein XP_059599860.1 3419969 D 5061 CDS An01g14350 4977627 join(3433002..3433111,3433174..3433476,3433531..>3433566) II 1 NT_166518.1 Remark: C-terminal truncated ORF due to the end of contig.; Remark: alternate name for S. cerevisiae Ups2: YDR213W.; Remark: the similarities to the ORF encoded protein are only focused on the Zn(2)-Cys(6) binuclear cluster domain.; Similarity: the ORF encoded protein shows similarity to transcription factors of the fungal Zn(2)-Cys(6) binuclear cluster domain type.; Title: similarity to transcription factor Upc2 -Saccharomyces cerevisiae [truncated ORF]; See PMID 9696767; uncharacterized protein 3433566 4977627 An01g14350 Aspergillus niger uncharacterized protein XP_059599861.1 3433002 D 5061 CDS An01g14360 84590160 join(<3433667..3433674,3433758..3434703) II 1 NT_166518.1 Remark: N-terminal truncated ORF due to the end of contig.; Title: strong similarity to hypothetical protein 68B2.10 - Neurospora crassa [truncated ORF]; uncharacterized protein 3434703 84590160 An01g14360 Aspergillus niger uncharacterized protein XP_059599862.1 3433667 D 5061 CDS An01g14370 4977737 complement(join(3436951..3437204,3437288..3437406,3437462..3437549,3437598..3437688,3437746..3437812,3437907..3438014,3438068..3438396)) II 1 NT_166518.1 Remark: the recombinant uronate reductase and L-gulono-gamma-lactone oxidase from patent DE19604798-A1 can be used in L-ascorbic acid production from D-glucuronic or galacturonic acids.; Title: strong similarity to uronate dehydrogenase from patent DE19604798-A1 - Saccharomyces cerevisiae; uncharacterized protein 3438396 4977737 An01g14370 Aspergillus niger uncharacterized protein XP_059599863.1 3436951 R 5061 CDS An01g14380 84590161 complement(join(3438949..3439079,3439131..3439701,3439781..3439896,3439958..3440057)) II 1 NT_166518.1 Title: strong similarity to hypothetical protein B3E4.80 - Neurospora crassa; uncharacterized protein 3440057 84590161 An01g14380 Aspergillus niger uncharacterized protein XP_059599864.1 3438949 R 5061 CDS An01g14390 4977904 join(3440834..3440855,3440929..3441002,3441054..3441491,3441609..3442086,3442146..3445885) II 1 NT_166518.1 Remark: the HET-E gene of the fungus Podospora anserina is responsible for vegetative incompatibility.; Title: strong similarity to beta-transducin-like protein het-e - Podospora anserina; See PMID 7557402; See PMID 9435787; uncharacterized protein 3445885 4977904 An01g14390 Aspergillus niger uncharacterized protein XP_001389829.3 3440834 D 5061 CDS An01g14400 4977312 join(3446231..3446346,3446726..3446792,3446846..3447492,3447556..3447830,3447880..3448451) II 1 NT_166518.1 Remark: the cercosporin toxin resistance protein CRG1 from C. nicotianae is also described patent WO9841082-A1.; Title: similarity to cercosporin toxin resistance protein CRG1 - Cercospora nicotianae; See PMID 10517336; uncharacterized protein 3448451 4977312 An01g14400 Aspergillus niger uncharacterized protein XP_059599865.1 3446231 D 5061 CDS An01g14410 4977739 join(3449192..3449336,3449392..3449834) II 1 NT_166518.1 Similarity: the O-crystallin from Octopus dofleini is similar to phosphatidylethanolamine-binding proteins.; Title: weak similarity to O-crystallin - Octopus dofleini; See PMID 10350626; uncharacterized protein 3449834 4977739 An01g14410 Aspergillus niger uncharacterized protein XP_001389831.1 3449192 D 5061 CDS An01g14420 4977493 join(3450729..3451057,3451117..3451223,3451276..3451376,3451439..3451897) II 1 NT_166518.1 Catalytic activity: an epoxide + H(2)O <=> a glycol.; Remark: alternate name for soluble epoxide hydrolase SEH: cytosolic epoxide hydrolase CEH.; Remark: soluble epoxide hydrolase SEH from Homo sapiens: gene name EPHX2.; Similarity: the Human soluble epoxide hydrolase SEH is also described in patent US5445956-A.; Title: similarity to soluble epoxide hydrolase SEH -Homo sapiens; See PMID 8619856; See PMID 8678300; uncharacterized protein 3451897 4977493 An01g14420 Aspergillus niger uncharacterized protein XP_001389832.1 3450729 D 5061 CDS An01g14430 4978058 complement(join(3451999..3452122,3452209..3452749,3452808..3453495,3453806..3454177)) II 1 NT_166518.1 Function: the human SRPK2 kinase (also the SRPK1 kinase) specifically phosphorylates members of the SR family of splicing factors.; Similarity: the ORF encoded protein shows also similarity to the patent WO9938981-A2.; Title: similarity to serine kinase SRPK2 - Homo sapiens; See PMID 9446799; See PMID 9472028; uncharacterized protein 3454177 4978058 An01g14430 Aspergillus niger uncharacterized protein XP_059599866.1 3451999 R 5061 CDS An01g14440 4977932 complement(3454693..>3455748) II 1 NT_166518.1 Remark: N-terminal truncated ORF due to the end of contig.; Similarity: the similarity of the ORF encoded protein to all hits is based on repetitive structures.; Title: similarity to extracellular matrix protein lustrin A - Haliotis rufescens [truncated ORF]; See PMID 9405458; uncharacterized protein 3455748 4977932 An01g14440 Aspergillus niger uncharacterized protein XP_001389835.3 3454693 R 5061 CDS An01g14450 84590162 complement(<3455851..3457198) II 1 NT_166518.1 Remark: C-terminal truncated ORF due to the end of contig.; Remark: alternate name for Leishmania mexicana sap2: lmsap2.; Remark: the ORF encoded protein shows a repetitive structure.; Title: similarity to secreted acid phosphatase 2 precursor sap2 - Leishmania mexicana [truncated ORF]; extracellular/secretion proteins; See PMID 7720697; uncharacterized protein 3457198 84590162 An01g14450 Aspergillus niger uncharacterized protein XP_059603369.1 3455851 R 5061 CDS An01g14460 4977520 complement(join(3458364..3459617,3459677..3459967)) II 1 NT_166518.1 Remark: alternate name for S. cerevisiae Flr1: YBR008c.; Title: similarity to fluconazole resistance transporter Flr1 - Saccharomyces cerevisiae; See PMID 9235926; See PMID 10572257; uncharacterized protein 3459967 4977520 An01g14460 Aspergillus niger uncharacterized protein XP_001389836.1 3458364 R 5061 CDS An01g14480 4977052 complement(join(3462050..3462893,3462951..3463091,3463145..3463492,3463570..3463646,3463696..3463953)) II 1 NT_166518.1 Function: Atr1 from S. cerevisiae is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. It is a probable ATP-dependent export permease.; Remark: alternate names for S. cerevisiae Atr1: Snq1, YML116W or YM8339. 03.; Title: strong similarity to aminotriazole resistance protein Atr1 - Saccharomyces cerevisiae; plasma membrane; See PMID 3280970; See PMID 9046086; See PMID 2123132; uncharacterized protein 3463953 4977052 An01g14480 Aspergillus niger uncharacterized protein XP_059603370.1 3462050 R 5061 CDS An01g14490 84590163 complement(3465117..3466244) II 1 NT_166518.1 Remark: the ORF shows similarity to ankyrin-repeats,which are believed to mediate protein-protein interactions.; Title: similarity to ankyrin 2 Ank2 - Drosophila melanogaster; See PMID 7937942; uncharacterized protein 3466244 84590163 An01g14490 Aspergillus niger uncharacterized protein XP_059603371.1 3465117 R 5061 CDS An01g14500 4977785 complement(3466422..3467939) II 1 NT_166518.1 Catalytic activity: Benzoate + NADPH + O(2) <=> 4-hydroxybenzoate + NADP(+) + H(2)O.; Function: the P450rm-monooxygenase system in microsomes of R. minuta might function in the degradation of L-phenylalanine on the pathway to beta-ketoadipate.; Remark: the P450rm gene product from Rhodotorula minuta acts as a bifunctional enzyme with isobutene-forming and benzoate 4-hydroxylase activities.; Title: strong similarity to isobutene-forming enzyme and benzoate 4-hydroxylase P450rm - Rhodotorula minuta; See PMID 7764227; See PMID 8002981; See PMID 8882724; See PMID 9349702; uncharacterized protein 3467939 4977785 An01g14500 Aspergillus niger uncharacterized protein XP_001389839.1 3466422 R 5061 CDS An01g14510 4977547 join(3468751..3469482,3469552..3469593,3469647..3469746,3469799..3470325) II 1 NT_166518.1 Function: the S. cerevisiae Sec14 gene product is required for transport of secretory proteins from the golgi complex. It catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes in vitro.; Remark: in opposite to S. cerevisiae the SEC14 gene in Y. lipolytica is not essential.; Title: similarity to phosphatidylinositol-phosphatidylcholine transfer protein Sec14 - Yarrowia lipolytica; See PMID 8138566; uncharacterized protein 3470325 4977547 An01g14510 Aspergillus niger uncharacterized protein XP_001389840.1 3468751 D 5061 CDS An01g14520 4977615 join(3471745..3472060,3472121..3473283) II 1 NT_166518.1 Title: strong similarity to carbohydrate oxidase CHO from patent WO9931990-A1 - Microdochium nivale; uncharacterized protein 3473283 4977615 An01g14520 Aspergillus niger uncharacterized protein XP_001389841.3 3471745 D 5061 CDS An01g14530 4977422 complement(join(3473514..3473666,3473753..3474639,3474691..3474775)) II 1 NT_166518.1 Catalytic activity: (S)-2-hydroxy-acid + O(2) <=> 2-oxo acid + H(2)O(2).; Cofactor: FMN.; Pathway: the (S)-2-hydroxy-acid oxidase GOX from S. oleracea catalyzes the second reaction of the photorespiratory pathway (glycolate pathway).; Remark: the (S)-2-hydroxy-acid oxidase GOX from S. oleracea is also described in patent US5834262-A.; Title: strong similarity to (S)-2-hydroxy-acid oxidase GOX - Spinacia oleracea; peroxisome; See PMID 2644287; See PMID 2681790; See PMID 2824469; See PMID 3286256; uncharacterized protein 3474775 4977422 An01g14530 Aspergillus niger uncharacterized protein XP_001389842.3 3473514 R 5061 CDS An01g14540 4977323 complement(join(3477462..3477505,3477562..3478133,3478184..3478452,3478499..3478549,3478599..3478637,3478687..3479224,3479271..3479454,3479514..3479762,3479810..3479916,3480076..3480158)) II 1 NT_166518.1 Title: similarity to hypothetical protein CAD37157.1 - Aspergillus fumigatus; uncharacterized protein 3480158 4977323 An01g14540 Aspergillus niger uncharacterized protein XP_059603372.1 3477462 R 5061 CDS An01g14550 4977526 complement(join(3480807..3480980,3481033..3481077,3481132..3481344,3481408..3481898,3481952..3482099)) II 1 NT_166518.1 Catalytic activity: Formamide <=> cyanide + H(2)O.; Similarity: the cyanide hydratase Cht from G. sorghi belongs to the nitrilase family.; Title: strong similarity to cyanide hydratase Cht -Gloeocercospora sorghi; See PMID 1382413; uncharacterized protein 3482099 4977526 An01g14550 Aspergillus niger uncharacterized protein XP_001389844.1 3480807 R 5061 CDS An01g14560 4977899 complement(3484612..3485319) II 1 NT_166518.1 Remark: the fungal protein CIH1 from C. lindemuthianum is important for the fungus-host interaction. It is fungally encoded and Northern analysis showed that it is only expressed in planta.; Title: similarity to hypothetical intracellular hyphae protein 1 CIH1 - Colletotrichum lindemuthianum; See PMID 9721685; uncharacterized protein 3485319 4977899 An01g14560 Aspergillus niger uncharacterized protein XP_059603373.1 3484612 R 5061 CDS An01g14570 84590164 join(3487222..3487347,3487431..3487487,3487786..3487835,3487905..3487925,3488016..3488040) II 1 NT_166518.1 Title: questionable ORF; uncharacterized protein 3488040 84590164 An01g14570 Aspergillus niger uncharacterized protein XP_059603374.1 3487222 D 5061 CDS An01g14590 4978062 join(3488599..3488884,3488964..3489063,3489124..3489307,3489367..3489843) II 1 NT_166518.1 Catalytic activity: an alcohol + NAD(+) <=> an aldehyde or ketone + NADH.; Title: strong similarity to thermostable alcohol dehydrogenase adhT - Bacillus stearothermophilus; See PMID 4578954; See PMID 436831; See PMID 1735726; uncharacterized protein 3489843 4978062 An01g14590 Aspergillus niger uncharacterized protein XP_001389847.1 3488599 D 5061 CDS An01g14600 4977958 join(3491296..3491561,3491621..3492050) II 1 NT_166518.1 Function: the endo-1,4-beta-Xylanase B XynB from Aspergillus tubingensis endohydrolysis the 1,4-beta-D-xylosidic linkages in xylans.; Title: strong similarity to endo-1,4-beta-xylanase B xynB from patent WO9414965 - Aspergillus tubingensis; uncharacterized protein 3492050 4977958 An01g14600 Aspergillus niger uncharacterized protein XP_001389848.1 3491296 D 5061 CDS An01g14610 84590165 complement(join(3492283..3492444,3492535..3492543)) II 1 NT_166518.1 Title: questionable ORF; uncharacterized protein 3492543 84590165 An01g14610 Aspergillus niger uncharacterized protein XP_059603375.1 3492283 R 5061 CDS An01g14620 4978340 join(3493211..3493307,3493375..3493762,3493823..3494604,3494664..3494920) II 1 NT_166518.1 Induction: the transcript level of the C. albicans HGT1 gene is enhanced in the presence of drugs, e. g. cycloheximide, chloramphenicol and benomyl.; Title: strong similarity to hexose transporter HGT1 - Candida albicans; See PMID 10612724; uncharacterized protein 3494920 4978340 An01g14620 Aspergillus niger uncharacterized protein XP_001389850.1 3493211 D 5061 CDS An01g14630 4977787 complement(join(3495438..3495607,3495692..3495806)) II 1 NT_166518.1 hypothetical protein 3495806 4977787 An01g14630 Aspergillus niger hypothetical protein XP_001389851.3 3495438 R 5061 CDS An01g14640 4977559 join(3497782..3497899,3498015..3498285,3498354..3498906) II 1 NT_166518.1 Title: weak similarity to mucin 5AC - Homo sapiens; See PMID 7826332; uncharacterized protein 3498906 4977559 An01g14640 Aspergillus niger uncharacterized protein XP_001389852.1 3497782 D 5061 CDS An01g14650 4977826 join(3500204..3501055,3501103..3501155,3501200..3501326) II 1 NT_166518.1 Catalytic activity: {(1,4)-alpha-D-galacturonide}(N) + H(2)O <=> {(1,4)-alpha-D-galacturonide}(N-1) + D-galacturonate.; Title: strong similarity to exo-alpha 1,4-polygalacturonase PGX1 - Cochliobolus carbonum; extracellular/secretion proteins; See PMID 9546185; uncharacterized protein 3501326 4977826 An01g14650 Aspergillus niger uncharacterized protein XP_001389853.3 3500204 D 5061 CDS An01g14660 4977510 join(3503241..3503438,3503489..3503983,3504042..3504715,3504765..3504894) II 1 NT_166518.1 Remark: alternate name for S. cerevisiae Flr1: YBR008c.; Similarity: the ORF encoded protein also shows strong similarity to the protein descibed in patent JP09009966-A.; Title: similarity to fluconazole resistance transporter Flr1 - Saccharomyces cerevisiae; See PMID 9235926; See PMID 10572257; uncharacterized protein 3504894 4977510 An01g14660 Aspergillus niger uncharacterized protein XP_001389854.3 3503241 D 5061 CDS An01g14670 4977284 complement(join(3506860..3507182,3507242..3507371,3507422..3507844,3507895..3508155)) II 1 NT_166518.1 Function: the polygalacturonase E (PgaE) from A. niger random hydrolysis the 1,4-alpha-D-galactosiduronic linkages in pectate and in other galacturonans.; Gene-ID: pgaE; Remark: the amino acid sequence of the ORF encoded protein differs at two positions to the published PgaE sequence.; Similarity: the ORF encoded protein shows stong similarity to the protein described in patent EP421919-A.; See PMID 9492270; polygalacturonase E precursor pgaE-Aspergillus niger 3508155 pgaE 4977284 pgaE Aspergillus niger polygalacturonase E precursor pgaE-Aspergillus niger XP_001389855.1 3506860 R 5061 CDS An01g14680 4977535 join(3509391..3509484,3509538..3510117,3510168..3510603) II 1 NT_166518.1 Title: similarity to hypothetical protein SPCC576.01c - Schizosaccharomyces pombe; uncharacterized protein 3510603 4977535 An01g14680 Aspergillus niger uncharacterized protein XP_001389856.3 3509391 D 5061 CDS An01g14690 4977982 complement(join(3510780..3510902,3511059..3511136,3511186..3511280,3511343..3511651,3511701..3511850,3511901..3511994,3512058..3512320,3512374..3512412,3512500..3512679,3512736..3513000)) II 1 NT_166518.1 Remark: the Flu1 gene product from C. albicans complements the fluconazole hypersusceptibility of a S. cerevisiae pdr5 mutant, lacking the ABC (ATP-binding cassette) transporter gene PDR5.; Similarity: the ORF encoded protein also shows stong similarity to the protein described in patent JP09009966-A.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353; uncharacterized protein 3513000 4977982 An01g14690 Aspergillus niger uncharacterized protein XP_059603376.1 3510780 R 5061 CDS An01g14700 84590166 complement(join(3513503..3513634,3513862..3514005)) II 1 NT_166518.1 hypothetical protein 3514005 84590166 An01g14700 Aspergillus niger hypothetical protein XP_059603377.1 3513503 R 5061 CDS An01g14710 4977596 3516046..3517092 II 1 NT_166518.1 Title: weak similarity to cytochrome b Cytb -Anthophora pacifica; uncharacterized protein 3517092 4977596 An01g14710 Aspergillus niger uncharacterized protein XP_001389859.1 3516046 D 5061 CDS An01g14720 4977085 join(3518059..3518070,3518121..3520376) II 1 NT_166518.1 Function: AmdA (A. nidulans) fusions with the GAL4 DNA binding domain in S. cerevisiae revealed its ability to activate transcription.; Title: strong similarity to zinc-finger transcription factor amdA - Aspergillus nidulans; nucleus; See PMID 7596297; See PMID 9126617; uncharacterized protein 3520376 4977085 An01g14720 Aspergillus niger uncharacterized protein XP_059603378.1 3518059 D 5061 CDS An01g14730 4977984 complement(join(3520916..3521236,3521304..3521796,3521871..3522232)) II 1 NT_166518.1 Catalytic activity: 2,5-dihydro-5-oxofuran-2-acetate <=> cis,cis-hexadienedioate.; Cofactor: the cis,cis-muconate lactonizing enzyme I from T. cutaneum uses Manganese as cofactor.; Similarity: the ORF encoded protein is strong similar to some hypothetical proteins, see BlastP list.; Similarity: the ORF encoded protein shows a similarity to the cis,cis-muconate lactonizing enzyme I from T. cutaneum with an e-val. of 0. 065.; Title: similarity to cis,cis-muconate lactonizing enzyme I TcMLE - Trichosporon cutaneum; See PMID 8110801; uncharacterized protein 3522232 4977984 An01g14730 Aspergillus niger uncharacterized protein XP_059603379.1 3520916 R 5061 CDS An01g14740 4977376 3523455..3525272 II 1 NT_166518.1 Catalytic activity: beta-D-glucose + O(2) <=> D-glucono-1,5-lactone + H(2)O(2).; Cofactor: FAD.; Gene-ID: goxC;gox;ggox;god; Mapping: goxC from A. niger is mapped to chromosome II; see list from DSM.; Pathway: the goxC protein from A. niger is involved in the pentose-phosphate pathway.; Remark: the ORF has an irregular internal stop codon due to a putative sequencing error.; putative sequencing error; See PMID 2792372; See PMID 8299156; See PMID 2406261; glucose oxidase precursor goxC-Aspergillus niger [putative sequencing error] 3525272 goxC 4977376 goxC Aspergillus niger glucose oxidase precursor goxC-Aspergillus niger [putative sequencing error] XP_001389862.3 3523455 D 5061 CDS An01g14750 84590167 complement(join(3525708..3527077,3527123..3527177,3527386..3527634,3527802..3527860,3528023..3528045,3528113..3528229,3528442..3529223)) II 1 NT_166518.1 Title: similarity to hypothetical tol like protein CAD37049.1 - Neurospora crassa; uncharacterized protein 3529223 84590167 An01g14750 Aspergillus niger uncharacterized protein XP_059603380.1 3525708 R 5061 CDS An01g14760 4977269 join(3532615..3533244,3533295..3534065) II 1 NT_166518.1 Catalytic activity: (R)-6-hydroxynicotine + H(2)O + O(2) <=> 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H(2)O(2).; Cofactor: the 6-hydroxy-D-nicotine oxidase 6-HDNO from Arthrobacter oxidans from uses FAD as cofactor.; Induction: the expression of the 6-HDNO protein in Arthrobacter oxidans is linked to the presence of nicotine.; Title: strong similarity to 6-hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 3622516; See PMID 3905431; See PMID 1700696; uncharacterized protein 3534065 4977269 An01g14760 Aspergillus niger uncharacterized protein XP_001389864.1 3532615 D 5061 CDS An01g14770 4977595 complement(join(3534130..3536431,3536487..3536538,3536598..3536972,3537008..3537028,3537079..3537161,3537386..3537456)) II 1 NT_166518.1 Function: AmdA (A. nidulans) fusions with the GAL4 DNA binding domain in S. cerevisiae revealed its ability to activate transcription.; Title: strong similarity to zinc-finger transcription factor amdA - Aspergillus nidulans; nucleus; See PMID 7596297; See PMID 9126617; uncharacterized protein 3537456 4977595 An01g14770 Aspergillus niger uncharacterized protein XP_001389865.3 3534130 R 5061 CDS An01g14780 4977401 join(3537753..3538260,3538314..3538840) II 1 NT_166518.1 Remark: the ADH sequence 19 protein is part of the patent EP0845532 with the title: 'Enzymes for the synthesis of coniferyl alcohol, coniferyl aldehyde, ferulic acid,vanillin, vanillic acid and their applications'.; Remark: the organism of patent EP0845532 remains unclassified.; Title: strong similarity to alcohol dehydrogenase ADH from patent EP0845532 - Unclassified organism; uncharacterized protein 3538840 4977401 An01g14780 Aspergillus niger uncharacterized protein XP_001389866.1 3537753 D 5061 CDS An01g14790 4977489 complement(join(3539011..3539377,3539427..3539663,3539715..3539821)) II 1 NT_166518.1 Function: the nodL gene encodes a chitooligosaccharide O-acetyltransferase.; Remark: Rhizobia secrete specific lipo-chitooligosaccharide signals (LCOs) called Nod factors that are required for infection and nodulation of legumes.; Title: strong similarity to NodL - Rhizobium meliloti; See PMID 8801423; See PMID 10406097; See PMID 1558960; uncharacterized protein 3539821 4977489 An01g14790 Aspergillus niger uncharacterized protein XP_001389867.1 3539011 R 5061 CDS An01g14800 4978070 3543425..3545152 II 1 NT_166518.1 Catalytic activity: digallate + H(2)O <=> 2 gallate.; Similarity: the tannase from Aspergillus oryzae (PubMed 9146733 and 8917102) is identical to patent JP08080196-A.; Title: strong similarity to precursor of tannase -Aspergillus oryzae; See PMID 8917102; See PMID 9146733; uncharacterized protein 3545152 4978070 An01g14800 Aspergillus niger uncharacterized protein XP_001389868.1 3543425 D 5061 CDS An01g14810 84590168 complement(join(3545702..3545863,3545927..3546147,3546279..3546423)) II 1 NT_166518.1 Similarity: the similarity of the ORF encoded protein to all hits is based on repetitive structures.; Title: weak similarity to hypothetical protein SPAC19B12.02c - Schizosaccharomyces pombe; uncharacterized protein 3546423 84590168 An01g14810 Aspergillus niger uncharacterized protein XP_059603381.1 3545702 R 5061 CDS An01g14820 4977773 join(3548184..3548382,3548448..3548519,3548569..3549116) II 1 NT_166518.1 Remark: alternate name for S. cerevisiae YNL283c: WSC2.; Similarity: the ORF is about half as long as YNL283c of S. cerevisiae.; Similarity: the similarity of the ORF encoded protein to all hits is based on repetitive structures.; Title: similarity to hypothetical membrane protein YNL283c - Saccharomyces cerevisiae; uncharacterized protein 3549116 4977773 An01g14820 Aspergillus niger uncharacterized protein XP_001389870.1 3548184 D 5061 CDS An01g14830 84590169 join(3549412..3549472,3549557..3549597,3549683..3549730) II 1 NT_166518.1 Title: questionable ORF; uncharacterized protein 3549730 84590169 An01g14830 Aspergillus niger uncharacterized protein XP_059603382.1 3549412 D 5061 CDS An01g14840 4978517 join(3550280..3550690,3550748..3551101) II 1 NT_166518.1 Title: similarity to hypothetical protein SC4B10.33 - Streptomyces coelicolor; uncharacterized protein 3551101 4978517 An01g14840 Aspergillus niger uncharacterized protein XP_001389872.1 3550280 D 5061 CDS An01g14850 84590170 complement(3551273..3552163) II 1 NT_166518.1 Catalytic activity: ATP + D-gluconate <=> ADP + 6-phospho-D-gluconate.; Function: the GntV gene product from E. coli catalyzes the phosphorylation of D-gluconate to 6-phospho-D-gluconate.; Title: similarity to gluconokinase gntV -Escherichia coli; See PMID 3040894; See PMID 9151423; uncharacterized protein 3552163 84590170 An01g14850 Aspergillus niger uncharacterized protein XP_059603383.1 3551273 R 5061 CDS An01g14860 4978069 complement(join(<3552784..3554370,3554433..3554663)) II 1 NT_166518.1 Catalytic activity: ATP + O-succinylbenzoate + CoA <=> AMP + diphosphate + O-succinylbenzoyl-CoA.; Pathway: the O-succinylbenzoate--CoA ligase MenE of Bacillus subtilis is involved in the menaquinon biosynthesis.; Remark: putative C-terminal truncated ORF due to the end of contig.; Title: similarity to O-succinylbenzoate--CoA ligase menE - Bacillus subtilis [truncated ORF]; See PMID 1629163; See PMID 6780514; See PMID 6780515; uncharacterized protein 3554663 4978069 An01g14860 Aspergillus niger uncharacterized protein XP_001389874.3 3552784 R 5061 CDS An01g14870 4977527 complement(3555217..3556029) II 1 NT_166518.1 Title: weak similarity to hypothetical inner membrane protein - Helicobacter pylori; uncharacterized protein 3556029 4977527 An01g14870 Aspergillus niger uncharacterized protein XP_001389875.1 3555217 R 5061 CDS An01g14880 4977962 complement(join(3556433..3557069,3557136..3557470)) II 1 NT_166518.1 Catalytic activity: an alcohol + NADP(+) <=> an aldehyde + NADPH.; Remark: alternate names for the alcohol dehydrogenase/aldehyde reductase AKR1A1 from H. sapiens: ALR or ALDR1.; Title: strong similarity to alcohol dehydrogenase/aldehyde reductase AKR1A1 - Homo sapiens; See PMID 10510318; See PMID 2498333; uncharacterized protein 3557470 4977962 An01g14880 Aspergillus niger uncharacterized protein XP_001389876.1 3556433 R 5061 CDS An01g14890 4977222 join(3557730..3558135,3558197..3558699,3558764..3558811) II 1 NT_166518.1 Title: strong similarity to hypothetical protein CAD27299.1 - Aspergillus fumigatus; uncharacterized protein 3558811 4977222 An01g14890 Aspergillus niger uncharacterized protein XP_001389877.1 3557730 D 5061 CDS An01g14900 4977618 join(3560093..3560216,3560277..3560434,3560493..3560689,3560757..3560909,3560965..3561244,3561303..3561842) II 1 NT_166518.1 Induction: transcription of the yeast TNA1 gene is not only regulated by nicotinate but also by p-aminobenzoate.; Remark: the S. cerevisiae gene product Tna1 (=YGR260w) belongs to the Dal5 tranporter family.; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563; See PMID 10984621; uncharacterized protein 3561842 4977618 An01g14900 Aspergillus niger uncharacterized protein XP_001389878.1 3560093 D 5061 CDS An01g14910 4977818 complement(join(3561999..3562060,3562149..3564405)) II 1 NT_166518.1 Function: facB gene of Aspergillus nidulans is a major regulatory gene involved in acetamide and acetate utilisation.; Remark: the ORF encoded protein belongs to the family of GAL4-type zinc cluster transcriptional regulators (Zn(II)2Cys6 transcriptional activator).; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus niger; See PMID 9197408; See PMID 10483720; uncharacterized protein 3564405 4977818 An01g14910 Aspergillus niger uncharacterized protein XP_059599867.1 3561999 R 5061 CDS An01g14920 4978063 complement(join(3565347..3565540,3565617..3565776,3565830..3565941,3566002..3566083,3566131..3566229,3566280..3566688,3566739..3567005,3567058..3567201)) II 1 NT_166518.1 Cofactor: manganese or cobalt.; Function: Xaa-Pro aminopeptidases catalyze the release of any N-terminal amino acid, including proline,that is linked with proline, even from a dipeptide or tripeptide.; Remark: the aminopeptidase P (PepQ) from Lactococcus lactis belongs to the class of Xaa-Pro aminopeptidases.; Similarity: the ORF encoded protein shows a higher similarity to the protein described in patent WO9909145-A1,but the patent contains no further functional characterization.; Title: similarity to aminopeptidase P pepP -Lactococcus lactis; See PMID 10543778; See PMID 7770058; uncharacterized protein 3567201 4978063 An01g14920 Aspergillus niger uncharacterized protein XP_001389880.1 3565347 R 5061 CDS An01g14930 4977813 join(3567660..3568144,3568204..3568572,3568626..3569298) II 1 NT_166518.1 Remark: alternate name for S. cerevisiae Git1: YCR098c.; Remark: glycerophosphoinositol can be used by phospholipid biosynthesis in yeast.; Title: strong similarity to glycerophosphoinositol transporter Git1 - Saccharomyces cerevisiae; plasma membrane; See PMID 9691030; uncharacterized protein 3569298 4977813 An01g14930 Aspergillus niger uncharacterized protein XP_001389881.1 3567660 D 5061 CDS An01g14940 4977382 complement(join(3570236..3571036,3571102..3571665)) II 1 NT_166518.1 Catalytic activity: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate.; Similarity: the protein shows also similarity to the phospholipase C (EC 3. 1. 4. 3) of Pseudomonas aeruginosa.; Title: similarity to nonhemolytic phospholipase C PC-PLC - Burkholderia pseudomallei; See PMID 10523590; uncharacterized protein 3571665 4977382 An01g14940 Aspergillus niger uncharacterized protein XP_001389882.1 3570236 R 5061 CDS An01g14950 4978507 3573062..3574147 II 1 NT_166518.1 Remark: introduction of the R. etli ans operon (including the ansA gene) into Sinorhizobium meliloti induced growth with asparagine as the sole carbon and nitrogen source.; Title: strong similarity to L-asparaginase II AnsA -Rhizobium etli; See PMID 10930734; uncharacterized protein 3574147 4978507 An01g14950 Aspergillus niger uncharacterized protein XP_001389883.1 3573062 D 5061 CDS An01g14960 4977644 join(3574855..3575020,3575078..3575778,3575839..3576108) II 1 NT_166518.1 Catalytic activity: L-asparagine + H(2)O <=> L-aspartate + NH(3).; Remark: alternate name for S. cerevisiae Asp3: YLR155c.; Similarity: the ORF encoded protein shows also strong similarity to the asparaginase from Erwinia chrysanthemi (patent EP211639-A).; Title: strong similarity to asparaginase II Asp3 -Saccharomyces cerevisiae; extracellular/secretion proteins; See PMID 9170245; See PMID 3042786; uncharacterized protein 3576108 4977644 An01g14960 Aspergillus niger uncharacterized protein XP_001389884.1 3574855 D 5061 CDS An01g14970 4977288 join(3577371..3577796,3577869..3578178,3578246..3578691) II 1 NT_166518.1 Pathway: the microsomal delta-12 desaturase from Zea mays (patent WO9411516-A) is involved in the biosynthesis of unsaturated fatty acids.; Remark: EC 1. 14. 99. -. .; Remark: accumulation of the hydroxylase may be controlled post-transcriptionally in Lesquerella fendleri.; Remark: enzyme has oleate delta-12 desaturase activity and oleate 12-hydroxylase activity in Lesquerella fendleri.; Title: strong similarity to bifunctional oleate 12-hydroxylase:desaturase LFAH12 - Lesquerella fendleri; See PMID 9680976; uncharacterized protein 3578691 4977288 An01g14970 Aspergillus niger uncharacterized protein XP_059599868.1 3577371 D 5061 CDS An01g14980 4978036 complement(join(3579749..3580453,3580509..3580721)) II 1 NT_166518.1 Expression: significant DNA similarities to Aspergillus nidulans EST.; Title: strong similarity to hypothetical protein encoded by An10g00840 - Aspergillus niger; uncharacterized protein 3580721 4978036 An01g14980 Aspergillus niger uncharacterized protein XP_001389886.1 3579749 R 5061 CDS An01g14990 4978005 complement(join(3581610..3581945,3582018..3582285,3582348..3582514,3582638..3582927,3582961..3583092,3583172..3583241,3583305..3583385)) II 1 NT_166518.1 Function: the TRI11 gene product from F. sporotrichioides catalyzes the hydroxylation at C-15 of isotricodermin.; Remark: disruption of TRI11 gene from F. sporotrichioides results in an altered trichothecene production phenotype characterized by the accumulation of isotrichodermin, a trichothecene pathway intermediate.; Remark: trichothecenes are sesquiterpenoid toxins that act by inhibiting protein biosynthesis.; Similarity: the TRI11 gene product from F. sporotrichioides belongs to the cytochrome p450 family.; Title: strong similarity to cytochrome P450 monooxygenase TRI11 - Fusarium sporotrichioides; See PMID 9435078; uncharacterized protein 3583385 4978005 An01g14990 Aspergillus niger uncharacterized protein XP_059599869.1 3581610 R 5061 CDS An01g15000 4977901 complement(join(3584850..3585921,3586014..3586639)) II 1 NT_166518.1 Function: it has been proposed that C. carbonum TOXA encodes an HC-toxin efflux pump which contributes to self-protection against HC-toxin and/or the secretion of HC-toxin into the extracellular milieu.; Remark: the predicted A. niger protein occurs from a genomic region containing aflatoxin biosynthesis genes.; Title: strong similarity to HC-toxin efflux pump TOXA - Cochliobolus carbonum; plasma membrane; See PMID 8704997; uncharacterized protein 3586639 4977901 An01g15000 Aspergillus niger uncharacterized protein XP_001389888.1 3584850 R 5061 CDS An01g15010 4977054 join(3587196..3587483,3587534..3588049,3588106..3588630) II 1 NT_166518.1 Catalytic activity: A. flavus omtA converts S-adenosyl-L-methionine + sterigmatocystin to S-adenosyl-L-homocysteine + 7-O-methylsterigmatocystin.; Function: A. flavus omtA forms part of the aflatoxin biosynthesis pathway and is involved in the conversion of sterigmatocystin to o- methylsterigmatocystin and dihydrosterigmatocystin to dihydro-o-methylsterigmatocystin.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Title: similarity to O-methyltransferase omtA -Aspergillus flavus; See PMID 7557460; uncharacterized protein 3588630 4977054 An01g15010 Aspergillus niger uncharacterized protein XP_059599870.1 3587196 D 5061 CDS An01g15020 4977290 join(3589499..3589564,3589660..3589792,3589883..3590066,3590140..3590917) II 1 NT_166518.1 Catalytic activity: A. flavus omtB converts demethylsterigmatocystin (DMST) to sterigmatocystin (ST) and dihydrodemethylsterigmatocystin (DHDMST) to dihydrosterigmatocystin (DHST).; Function: A. flavus omtB is a demethylsterigmatocystin 6-O-methyltransferase involved in aflatoxin biosynthesis.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Title: similarity to O-methyltransferase omtB -Aspergillus flavus; See PMID 10806361; uncharacterized protein 3590917 4977290 An01g15020 Aspergillus niger uncharacterized protein XP_059599871.1 3589499 D 5061 CDS An01g15030 84590171 complement(3591516..3591872) II 1 NT_166518.1 Remark: blastp shows significant similarity (41% positives) between the predicted A. niger protein and M. mulatta TCR A but due to shortness of both peptides the calculated probability is low (p=2,4).; Remark: information regarding M. mulatta TCR A has not yet been published and is available from EMBL.; Similarity: the predicted A. niger protein contains a NK-cell receptor motif.; Title: weak similarity to T-cell receptor alpha tcrA - Macaca mulatta; uncharacterized protein 3591872 84590171 An01g15030 Aspergillus niger uncharacterized protein XP_059599872.1 3591516 R 5061 CDS An01g15040 84590172 complement(join(3592510..3592722,3592837..3592956)) II 1 NT_166518.1 hypothetical protein 3592956 84590172 An01g15040 Aspergillus niger hypothetical protein XP_059599873.1 3592510 R 5061 CDS An01g15050 84590173 3594568..>3594720 II 1 NT_166518.1 Remark: ORF 3'truncated due to end of contig.; Title: strong similarity to hypothetical protein YDR090c - Saccharomyces cerevisiae [truncated ORF]; uncharacterized protein 3594720 84590173 An01g15050 Aspergillus niger uncharacterized protein XP_059599874.1 3594568 D 5061 CDS An01g15060 4977933 join(3595248..3595373,3595426..3595564,3595619..3595675,3595726..3595774,3595828..3595957) II 1 NT_166518.1 Title: similarity to hypothetical protein YDR090c -Saccharomyces cerevisiae; uncharacterized protein 3595957 4977933 An01g15060 Aspergillus niger uncharacterized protein XP_059599875.1 3595248 D 5061 CDS An01g15070 4977247 complement(join(3595967..3597291,3597397..3597412)) II 1 NT_166518.1 Function: in N. crassa the acr-2 mutation confers acriflavine resistance.; Similarity: N. crassa acr-2 contains a putative Zn(II)Cys6 binuclear DNA-binding domain.; Similarity: similarity is relatively high beteween the N-terminal region of N. crassa acr-2 and the predicted A. niger protein, low for the rest of the sequence.; Similarity: the N-terminus of the predicted A. niger protein contains a low probability putative Zn(II)Cys6 binuclear DNA-binding domain.; Title: weak similarity to transcription factor involved in acriflavine resistance acr-2 - Neurospora crassa; See PMID 8679704; uncharacterized protein 3597412 4977247 An01g15070 Aspergillus niger uncharacterized protein XP_059599876.1 3595967 R 5061 CDS An01g15080 4977908 complement(join(3597683..3598420,3598501..3598629,3598775..3599326)) II 1 NT_166518.1 Title: strong similarity to transposase of Tan1 -Aspergillus niger; See PMID 9003286; uncharacterized protein 3599326 4977908 An01g15080 Aspergillus niger uncharacterized protein XP_059599877.1 3597683 R 5061 CDS An01g15100 4977178 complement(join(3600258..3600935,3601007..3601174,3601247..3601417)) II 1 NT_166518.1 Catalytic activity: gibberellin (GA) 7-oxidase oxidizes GA12-aldehyde to GA12 and GA14-aldehyde to GA14 they further metabolise GA12 to four products, two of which are monohydroxylated GA12.; Function: gibberellin (GA) plant hormones are biosynthesized via complex pathways, the final steps of which are catalyzed by 2-oxoglutarate-dependent dioxygenases.; Title: similarity to gibberellin 7-oxidase -Cucurbita maxima; See PMID 9177256; uncharacterized protein 3601417 4977178 An01g15100 Aspergillus niger uncharacterized protein XP_001389897.1 3600258 R 5061 CDS An01g15110 4977528 join(3602135..3602481,3602528..3603726,3603781..3603926) II 1 NT_166518.1 Catalytic activity: benzoate 4-monooxygenases convert benzoate + NADPH2 + O2 to 4-hydroxybenzoate + NADP + H2O.; Function: in A. niger bphA and cprA are the two cytochrome P450s required for the para-hydroxylation of benzoate.; Induction: A. niger bphA is inducible by benzoate.; Similarity: A. niger bphA is a cytochrome P450 of the pisatin demethylase family.; Title: strong similarity to benzoate 4-monooxygenase cytochrome P450 53 bphA - Aspergillus niger; endoplasmatic reticulum; See PMID 10852481; See PMID 2250647; uncharacterized protein 3603926 4977528 An01g15110 Aspergillus niger uncharacterized protein XP_001389898.1 3602135 D 5061 CDS An01g15120 10098040 complement(join(3604097..3604681,3604815..3604938,3605028..3605152,3605236..3605310)) II 1 NT_166518.1 hypothetical protein 3605310 10098040 An01g15120 Aspergillus niger hypothetical protein XP_003188571.2 3604097 R 5061 CDS An01g15130 4977978 complement(join(3607086..3608516,3608594..3608716)) II 1 NT_166518.1 Function: S. cerevisiae ATR1 is a membrane-associated component of the machinery responsible for pumping aminotriazole, 4-nitroquinoline-N-oxide (and possibly other toxic compounds) out of the cell.; Function: S. cerevisiae cells with multiple copies of ATR1 accumulated less aminotriazole than wild-type cells, whereas cells with the atr1 deletion mutation retained more aminotriazole.; Function: total deletion of the S. cerevisiae ATR1 region coding for a ATP-binding domain leads to 4-nitroquinoline-N-oxide sensitive null-mutants.; Induction: ATR1 transcription is induced by aminotriazole.; Induction: ATR1 transcription is induced by the basic region-leucine zipper transcription factors YAP1 and GCN4.; Similarity: S. cerevisiae ATR1 belongs to the major facilitator family of transmembrane transport proteins.; Title: strong similarity to aminotriazole resistance protein Atr1 - Saccharomyces cerevisiae; plasma membrane; See PMID 9287330; See PMID 2123132; See PMID 3280970; uncharacterized protein 3608716 4977978 An01g15130 Aspergillus niger uncharacterized protein XP_001389900.3 3607086 R 5061 CDS An01g15140 4978049 join(3609254..3609361,3609451..3609577,3609649..3610311,3610392..3610537,3610622..3610807) II 1 NT_166518.1 Catalytic activity: agmatinase of E. coli catalyzes the reversible reaction H2O + agmatine <=> urea + putrescine.; Complex: agmatinase of E. coli is an homodimer of two speB-encoded polypeptides.; Function: agmatinase of E. coli is part of the second putrescine biosynthetic pathway, and also represents the only pathway for urea biosynthesis in E. coli as no urease is present.; Pathway: agmatinase of E. coli is part of the polyamine biosynthesis, and arginine utilization pathways.; Repression: agmatinase of E. coli is inhibited by L-arginine and L-ornitine.; Similarity: agmatinase of E. coli belongs to the arginase protein family.; Title: strong similarity to agmatinase speB -Escherichia coli; See PMID 2153656; See PMID 3081491; See PMID 3157043; uncharacterized protein 3610807 4978049 An01g15140 Aspergillus niger uncharacterized protein XP_001389901.1 3609254 D 5061 CDS An01g15150 84590174 complement(join(3611185..3611731,3611786..3612429,3612529..3613431,3613493..3613516)) II 1 NT_166518.1 Function: facB of A. nidulans is a major regulatory gene involved in acetamide and acetate utilisation, as indicated by genetic studies.; Similarity: the N-terminal region of the predicted ORF contains a fungal Zn(2)-Cys(6) binuclear cluster domain, a cysteine-rich region that binds DNA, and is found in many fungal transcriptional activators.; Similarity: the predicted ORF shows similarity or strong similarity to several putative transcription factors.; Similarity: the similarity to facB of A. nidulans is particularly strong in the N-terminal region.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; See PMID 9197408; uncharacterized protein 3613516 84590174 An01g15150 Aspergillus niger uncharacterized protein XP_059599878.1 3611185 R 5061 CDS An01g15160 84590175 complement(join(3615125..3615693,3615729..3615765)) II 1 NT_166518.1 Function: dik of H. sapiens exhibit protein kinase activity toward autophosphorylation and substrate phosphorylation.; Function: many ankyrin repeat regions are known to function as protein-protein interaction domains.; Remark: ankyrin repeats are tandemly repeated modules of about 33 amino acids that occur in a large number of functionally diverse proteins mainly from eukaryotes.; Similarity: the predicted ORF also contains two ZU5 domains, that are domains of unknown function present in ZO-1 and Unc5-like netrin receptors.; Similarity: the predicted ORF contains two putative ankyrin repeats, which justify many BLASTP matches,comprised dik of H. sapiens.; Title: similarity to protein kinase dik - Homo sapiens; See PMID 10948194; uncharacterized protein 3615765 84590175 An01g15160 Aspergillus niger uncharacterized protein XP_059599879.1 3615125 R 5061 CDS An01g15170 84590176 join(3615767..3615795,3615830..3615891,3615966..3616483) II 1 NT_166518.1 Catalytic activity: aldehyde dehydrogenase catalyzes the following reversible reaction: aldehyde + NAD(+) + H2O <=> acid + NADH.; Function: aldehyde dehydrogenase catalyzes the second step in ethanol utilization, and enables Aspergillus to grow on ethanol as carbon source.; Similarity: aldehyde dehydrogenases represent a large protein family with a wide substrate specificity.; Similarity: the predicted ORF shows a slightly weaker similarity to the aldehyde dehydrogenase gene AldA of A. niger than to the A. nidulans homologue.; Similarity: the predicted ORF shows strong similarity only to the C-terminal part of various aldehyde dehydrogenases; the gene model could not be extended in the N-terminal direction, because there is no similarity with aldehyde dehydrogenase genes at the genomic level in the 5' region.; Title: strong similarity to aldehyde dehydrogenase aldA - Aspergillus nidulans; See PMID 11102439; See PMID 2606357; uncharacterized protein 3616483 84590176 An01g15170 Aspergillus niger uncharacterized protein XP_059599880.1 3615767 D 5061 CDS An01g15180 84590177 complement(join(3617792..3618002,3618053..3618236,3618274..3618376,3618411..3618731)) II 1 NT_166518.1 Catalytic activity: AFAR of R. norvegicus exhibits aldehyde reductase activity and is capable of converting the protein-binding dialdehyde form of AFB1-dihydrodiol to the nonbinding dialcohol metabolite.; Function: AFAR of R. norvegicus and other mammals (comprising humans) is important for the protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1).; Similarity: the predicted ORF shows similarity also to the human CPRM3 protein patented under patentnumber WO9859055-A2 for clinical applications.; Similarity: the predicted ORF shows similarity with other aldo-keto and alcohol reductases, as well as a weaker similarity to some potassium channels of bacteria and plants.; Similarity: the similarity of the predicted ORF to AFAR of R. norvegicus is limited to the C-terminal half of the protein.; Title: similarity to aflatoxin B1 aldehyde reductase AFAR - Rattus norvegicus; See PMID 8234296; uncharacterized protein 3618731 84590177 An01g15180 Aspergillus niger uncharacterized protein XP_059599881.1 3617792 R 5061 CDS An01g15190 4977356 join(3620729..3621074,3621180..3621934) II 1 NT_166518.1 Catalytic activity: alcohol dehydrogenases catalyze the reversible reaction alcohol + NAD(+) <=> aldehyde or ketone + NADH.; Cofactor: members of this family of alchool dehydrogenases require Zn for their activity, and use NAD or NADP as electron exchangers.; Similarity: fdh of M. marinus belongs to the zinc-containing alcohol dehydrogenase family, and to ADH class-III subfamily.; Similarity: the predicted ORF shows strong similarity with a number of known and putative alcohol and aldehyde dehydrogenases, with very wide substrate specificities.; Title: strong similarity to glutathione-dependent formaldehyde dehydrogenase FDH - Methylobacter marinus; See PMID 7926692; uncharacterized protein 3621934 4977356 An01g15190 Aspergillus niger uncharacterized protein XP_001389906.3 3620729 D 5061 CDS An01g15200 4978211 join(3623923..3624224,3624293..3624698,3624761..3624889,3624949..3625481,3625545..>3625813) II 1 NT_166518.1 Function: PVA of F. oxysporum is used for the enzymatic hydrolysis of penicillin V (phenoxy-methylpenicillin) to 6-aminopenicillanic acid (6-APA).; Remark: 6-APA is the active beta-lactam nucleus used in the manufacture of semi-synthetic penicillins.; Remark: C-terminally truncated ORF due to contig border.; Title: strong similarity to mature penicillin V amidohydrolase PVA from patent US5516679-A - Fusarium oxysporum [truncated ORF]; uncharacterized protein 3625813 4978211 An01g15200 Aspergillus niger uncharacterized protein XP_059599882.1 3623923 D 5061 CDS An13g00010 4986474 join(863..867,918..2337,2408..2720,2836..2984) II 1 NT_166528.1 Title: similarity to hypothetical kinetoplast-associated like protein CAD37020.1 - Neurospora crassa; uncharacterized protein 2984 4986474 An13g00010 Aspergillus niger uncharacterized protein XP_001396143.1 863 D 5061 CDS An13g00020 4986462 complement(join(3664..4046,4130..4455,4511..4620,4670..4969,5016..6645,6695..6899,6958..7288)) II 1 NT_166528.1 Function: inp52 of S. cerevisiae is involved in vesicle cycling, e. g. protein sorting at the trans-Golgi network probably by acting in membrane formation.; Phenotype: S. cerevisiae inp52 null mutants are viable, but have abnormal vacuoles.; Remark: inp52 of S. cerevisiae is also called YNL106C, SJL2 or hypothetical protein N2160.; Similarity: the ORF overlaps with A. niger EST EMBLEST:BE760099.; Title: strong similarity to inositol-1,4,5-triphosphate 5-phosphatase Inp52 - Saccharomyces cerevisiae; See PMID 9560389; See PMID 10224048; See PMID 10947947; See PMID 11094088; uncharacterized protein 7288 4986462 An13g00020 Aspergillus niger uncharacterized protein XP_059604562.1 3664 R 5061 CDS An13g00030 4986469 join(8130..8152,8229..9042,9100..9120) II 1 NT_166528.1 Similarity: the ORF overlaps with A. niger EST EMBLEST:BE759558.; Similarity: the ORF shows some similarity to the peptidylprolyl isomerase FPR4 of S. cerevisiae.; Title: strong similarity to hypothetical protein YGR280c - Saccharomyces cerevisiae; See PMID 9371805; uncharacterized protein 9120 4986469 An13g00030 Aspergillus niger uncharacterized protein XP_001396145.1 8130 D 5061 CDS An13g00040 4986458 join(10102..10301,10374..11400) II 1 NT_166528.1 Catalytic activity: 1-acylglycerol-3-phosphate O-acyltransferases convert Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate <=> CoA + 1,2-diacyl-sn-glycerol 3-phosphate.; Function: 1-acylglycerol-3-phosphate O-acyltransferase mr1 of M. ramanniana is active in the formation of triacylglycerol from diacylglycerol and fatty acyl substrates.; Title: strong similarity to 1-acylglycerol-3-phosphate O-acyltransferase from patent WO200001713-A2 - Mortierella ramanniana; uncharacterized protein 11400 4986458 An13g00040 Aspergillus niger uncharacterized protein XP_001396146.1 10102 D 5061 CDS An13g00050 4986482 complement(join(12839..14910,14985..15753)) II 1 NT_166528.1 Function: kin1 of U. maydis is required for filamentous growth of the fungi.; Function: kinesins are microtubule associated motors involved in the transport of membrane bound organelles,transport between the endoplasmic reticulum and the Golgi and transport of protein complexes to cellular destinations.; Title: strong similarity to kinesin motor protein kin1 - Ustilago maydis; cytoskeleton; uncharacterized protein 15753 4986482 An13g00050 Aspergillus niger uncharacterized protein XP_001396147.3 12839 R 5061 CDS An13g00060 84592774 complement(join(16365..16460,16727..16887,16920..16977,17171..17207,17364..17444,17544..17551)) II 1 NT_166528.1 Remark: the real presence of a modified carboxypeptidase-zinc binding PROSITE pattern is questionable.; hypothetical protein 17551 84592774 An13g00060 Aspergillus niger hypothetical protein XP_059604563.1 16365 R 5061 CDS An13g00070 84592775 complement(join(18656..19677,19807..19873)) II 1 NT_166528.1 Function: kin28 is implicated in the transition from transcription initiation to transcription elongation by phosphorylation of the carboxy-terminal domain (CTD) of the largest subunit of the RNA polymerase II complex.; Function: kin28 of S. cerevisiae is a subunit of general transcription factor TFIIH, a multiprotein complex required for RNA polymerase II transcription initiation.; Remark: kin28 of S. cerevisiae is also called YDL108W or D2330.; Title: strong similarity to subunit of transcription initiation factor TFIIH protein kinase Kin28 -Saccharomyces cerevisiae; deleted EC_number 2.7.1.37; nucleus; See PMID 9620805; See PMID 9875293; uncharacterized protein 19873 84592775 An13g00070 Aspergillus niger uncharacterized protein XP_059604564.1 18656 R 5061 CDS An13g00080 4986459 20447..21163 II 1 NT_166528.1 Title: strong similarity to hypothetical conserved protein B2F7.100 - Neurospora crassa; mitochondrial 37S ribosomal protein mS41 21163 4986459 An13g00080 Aspergillus niger mitochondrial 37S ribosomal protein mS41 XP_001396150.1 20447 D 5061 CDS An13g00090 4986453 complement(join(21629..22855,22905..23102,23167..23412)) II 1 NT_166528.1 Function: cyp51 of U. necator convers resistance of the obligate biotrophic grape powdery mildew fungus U. necator to sterol demethylation-inhibiting fungicides (DMIs) (a phenylalanine residue for a tyrosine residue at position 136 is leading to a higher resistance).; Function: cyp51 of U. necator is a cytochrome P450-like protein, which catalyses the C14-demethylation of lanosterol, necessary for ergosterol biosynthesis; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.; Remark: cyp51 of U. necator is also called CYPL1,P450-L1A1, sterol 14-alpha demethylase or P450-14DM.; Similarity: the ORF overlaps with A. niger EST EMBLEST:BE760185.; Title: strong similarity to eburicol 14 alpha-demethylase cyp51 - Uncinula necator; uncharacterized protein 23412 4986453 An13g00090 Aspergillus niger uncharacterized protein XP_059604565.1 21629 R 5061 CDS An13g00100 4986461 complement(join(24589..25226,25278..25294,25353..25483,25552..26144,26197..26228,26426..26556)) II 1 NT_166528.1 Function: dun1 of S. cerevisiae is involved in DNA repair by serine/threonine-specific protein phosphorylation.; Phenotype: S. cerevisiae dun1 null mutants are defective in DNA damage repair and in DNA damage-resposive induction of RNR genes, and sensitive to DNA damaging agents.; Remark: dun1 of S. cerevisiae is also called D2370 or YDL101.; Title: strong similarity to protein kinase Dun1 -Saccharomyces cerevisiae; deleted EC_number 2.7.1.37; nucleus; See PMID 10357828; uncharacterized protein 26556 4986461 An13g00100 Aspergillus niger uncharacterized protein XP_059604566.1 24589 R 5061 CDS An13g00110 4986454 join(27753..27793,28055..28286,28347..31055,31110..31218,31281..31418,31472..31832,31891..32262,32320..32575,32649..32852,32903..33190,33244..34512) II 1 NT_166528.1 Catalytic activity: stt4 of S. cerevisiae converts ATP + 1-phosphatidyl-1D-myo-inositol <=> ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.; Function: stt4 of S. cerevisiae is acting on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate.; Function: stt4 of S. cerevisiae is involved in the regulation of intracellular aminophospholipid transport, a cell cycle checkpoint controller, is important for the maintainance of vacuole morphology and cell wall integrity,and actin cytoskeleton organization by acting in the signal transduction pathway with PKC1.; Phenotype: S. cerevisiae stt4 null mutants have an osmoremedial phenotype, are bleomycin and staurosporine sensitive and arrest mostly in G2/M phase.; Remark: for development of antifungal drugs, the potential of 1-phosphatidylinositol 4-kinase as target is investigated.; Remark: stt4 of S. cerevisiae is also called BLM1,YLR305C or L2142.; Title: strong similarity to 1-phosphatidylinositol 4-kinase Stt4 - Saccharomyces cerevisiae; See PMID 9449533; See PMID 9582361; See PMID 9624007; See PMID 10930462; uncharacterized protein 34512 4986454 An13g00110 Aspergillus niger uncharacterized protein XP_059604567.1 27753 D 5061 CDS An13g00130 84592776 complement(36720..37559) II 1 NT_166528.1 hypothetical protein 37559 84592776 An13g00130 Aspergillus niger hypothetical protein XP_059604568.1 36720 R 5061 CDS An13g00140 4986481 complement(join(39929..40447,40521..41074,41140..41826,41890..42013)) II 1 NT_166528.1 Function: YT521 of R. norvegicus interats with the nuclear transcriptosomal component scaffold attachment factor B, and the 68-kDa Src substrate (Sam68) associated during mitosis.; Function: YT521 of R. norvegicus modulates alternative splice site selection in a concentration-dependent manner.; Title: similarity to splicing factor YT521 - Rattus norvegicus; nucleus; uncharacterized protein 42013 4986481 An13g00140 Aspergillus niger uncharacterized protein XP_001396155.1 39929 R 5061 CDS An13g00145 84592777 complement(join(43300..43588,43909..44120)) II 1 NT_166528.1 hypothetical protein 44120 84592777 An13g00145 Aspergillus niger hypothetical protein XP_059604569.1 43300 R 5061 CDS An13g00160 84592778 join(44690..44727,44815..44935,45015..45106,45271..45316,45364..45462,45568..45654,45814..45865,45925..46007) II 1 NT_166528.1 hypothetical protein 46007 84592778 An13g00160 Aspergillus niger hypothetical protein XP_059604570.1 44690 D 5061 CDS An13g00170 84592779 join(46468..46690,46762..46907,47191..47553) II 1 NT_166528.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF; uncharacterized protein 47553 84592779 An13g00170 Aspergillus niger uncharacterized protein XP_059604571.1 46468 D 5061 CDS An13g00180 84592780 complement(join(48542..48718,48911..49010,49094..49131)) II 1 NT_166528.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF; uncharacterized protein 49131 84592780 An13g00180 Aspergillus niger uncharacterized protein XP_059604572.1 48542 R 5061 CDS An13g00190 84592781 complement(join(49642..49689,49789..50049,50104..50145,50234..50353)) II 1 NT_166528.1 hypothetical protein 50353 84592781 An13g00190 Aspergillus niger hypothetical protein XP_059604573.1 49642 R 5061 CDS An13g00200 84592782 join(50472..50603,50719..50961,51015..51095) II 1 NT_166528.1 hypothetical protein 51095 84592782 An13g00200 Aspergillus niger hypothetical protein XP_059604574.1 50472 D 5061 CDS An13g00210 4986473 complement(join(51675..53070,53129..53219,53480..54992,55088..55236,55347..55410)) II 1 NT_166528.1 Similarity: the similarity to csx2 of S. pombe is much weaker than to the N. crassa protein and is only locally high in the C-terminal half of the ORF.; Title: strong similarity to hypothetical protein B14D6.480 - Neurospora crassa; uncharacterized protein 55410 4986473 An13g00210 Aspergillus niger uncharacterized protein XP_059604575.1 51675 R 5061 CDS An13g00220 4986464 complement(join(57196..58213,58279..58976)) II 1 NT_166528.1 Title: weak similarity to protein fragment SEQ ID NO:54900 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 58976 4986464 An13g00220 Aspergillus niger uncharacterized protein XP_001396163.3 57196 R 5061 CDS An13g00230 84592783 join(59107..59206,59284..59355,59411..59502) II 1 NT_166528.1 Remark: the ORF is questionable due to its short lenght of only 87 amino acids.; Title: questionable ORF; uncharacterized protein 59502 84592783 An13g00230 Aspergillus niger uncharacterized protein XP_059604576.1 59107 D 5061 CDS An13g00240 4986485 complement(join(60191..60422,60484..61236,61290..61416,61465..61511,61567..61787,61849..61907,61959..62033,62095..62203,62255..62584,62636..63549,63679..63727)) II 1 NT_166528.1 Function: the role of rad16 in the repair of DNA might be to change the chromatin structure of silenced genes to provide access for excision repair enzymes, but its activity seems not absolutely required for excision repair.; Phenotype: the S. cerevisiae rad16 mutant is deficient for repair of the HML alpha locus.; Remark: rad16 of S. cerevisiae shares homology with the rad54 protein involved in recombinational repair and SNF2, a transcription factor that possibly functions in transcription activation through an interaction with chromatin components that allows access of other factors involved in transcription.; Title: strong similarity to DNA repair protein Rad16 - Saccharomyces cerevisiae; nucleus; uncharacterized protein 63727 4986485 An13g00240 Aspergillus niger uncharacterized protein XP_001396165.3 60191 R 5061 CDS An13g00250 4986479 join(64260..64261,64322..64360,64432..64459,64562..65095,65151..65316,65477..66492) II 1 NT_166528.1 Function: rad7 of S. cerevisiae is one of 10 proteins involved in nucleotide excision repair of DNA damaged by UV light, bulky adducts or cross-linking agents.; Phenotype: S. cerevisiae rad7 mutants show partial incision defects.; Remark: rad7 of S. cerevisiae is also called YJR052W or J166.; Title: strong similarity to DNA repair protein Rad7 - Saccharomyces cerevisiae; nucleus; See PMID 9792654; See PMID 9001217; uncharacterized protein 66492 4986479 An13g00250 Aspergillus niger uncharacterized protein XP_059604577.1 64260 D 5061 CDS An13g00270 4986484 join(69593..69887,69983..70326,70432..72633) II 1 NT_166528.1 Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 9987114; See PMID 11152942; See PMID 8710886; See PMID 9383611; uncharacterized protein 72633 4986484 An13g00270 Aspergillus niger uncharacterized protein XP_059604578.1 69593 D 5061 CDS An13g00280 4986475 join(73812..73828,74431..74489,74556..74665,74787..74990) II 1 NT_166528.1 Complex: the S. cerevisiae homolog RPB11 is a RNA polymerase subunit unique to RNA polymerase II.; Title: strong similarity to 13.6 kD subunit of DNA-directed RNA polymerase II Rpb11 - Saccharomyces cerevisiae; nucleus; uncharacterized protein 74990 4986475 An13g00280 Aspergillus niger uncharacterized protein XP_001396168.1 73812 D 5061 CDS An13g00290 4986465 join(75617..76251,76304..77367,77452..78361,78435..78977,79044..80196) II 1 NT_166528.1 Function: the S. cerevisiae homolog PAN1 interacts with mRNA 3' ends and conditional mutations in PAN1 lead to an arrest of translation initiation and alterations in mRNA poly(A) tail length. distribution of cytosolic proteins is also affected in some cases.; Remark: alternative gene names for S. cerevisiae homolog are PAN1, MDP3 and MIP3.; Title: strong similarity to poly(A)-specific ribonuclease Pan1 - Saccharomyces cerevisiae; uncharacterized protein 80196 4986465 An13g00290 Aspergillus niger uncharacterized protein XP_059604579.1 75617 D 5061 CDS An13g00300 4986457 complement(join(80689..80894,80976..83445,83511..83717)) II 1 NT_166528.1 Title: strong similarity to hypothetical protein B14D6.440 - Neurospora crassa; uncharacterized protein 83717 4986457 An13g00300 Aspergillus niger uncharacterized protein XP_059604580.1 80689 R 5061 CDS An13g00310 4986456 join(84762..84838,84903..85479,85545..87536) II 1 NT_166528.1 Complex: the S. pombe homolog cnd2 is a subunit of the condensin complex which promotes mitotic chromosome condensation. The condensin complex contains two SMC (structural maintenance of chromosomes) and three non-SMC subunits, one is cnd2.; Localization: condensin subunits tagged with GFP were observed to alter dramatically their localization during the cell cycle, enriched in the nucleus during mitosis, but cytoplasmic during other stages.; Title: strong similarity to condensin complex component cnd2p - Schizosaccharomyces pombe; uncharacterized protein 87536 4986456 An13g00310 Aspergillus niger uncharacterized protein XP_001396171.1 84762 D 5061 CDS An13g00320 4986476 complement(join(88381..88917,88970..89437,89496..89789)) II 1 NT_166528.1 Title: strong similarity to EST SEQ ID NO:4066 from patent WO200056762-A2 - Aspergillus niger; uncharacterized protein 89789 4986476 An13g00320 Aspergillus niger uncharacterized protein XP_003188880.2 88381 R 5061 CDS An13g00330 84592784 complement(join(<90120..90136,90246..90285,90362..90530)) II 1 NT_166528.1 Remark: a putative sequencing error leads to a frameshift.; putative frameshift; hypothetical protein [putative frameshift] 90530 84592784 An13g00330 Aspergillus niger hypothetical protein [putative frameshift] XP_059604581.1 90120 R 5061 CDS An13g00340 84592785 join(90551..91023,91118..91151) II 1 NT_166528.1 hypothetical protein 91151 84592785 An13g00340 Aspergillus niger hypothetical protein XP_059604582.1 90551 D 5061 CDS An13g00350 84592786 complement(join(94108..94203,94266..94288,94333..94423)) II 1 NT_166528.1 hypothetical protein 94423 84592786 An13g00350 Aspergillus niger hypothetical protein XP_059604583.1 94108 R 5061 CDS An13g00360 84592787 complement(join(94809..95040,95248..95285,95371..95545,95627..95953,96062..96195)) II 1 NT_166528.1 Title: weak similarity to 31K proliferation related acidic leucine-rich protein PAL31 - Rattus norvegicus; uncharacterized protein 96195 84592787 An13g00360 Aspergillus niger uncharacterized protein XP_059604584.1 94809 R 5061 CDS An13g00370 4986451 96398..98320 II 1 NT_166528.1 Function: Crz1p contains zinc finger motifs and binds specifically to the CDRE (calcineurin-dependent response element) of several target genes in yeast.; Localization: calcineurin dephosphorylates Crz1p and this results in translocation of Crz1p to the nucleus.; Remark: calcineurin effects Ca2+-dependent changes in gene expression through regulation of the Crz1p transcription factor.; Remark: calcineurin is a conserved Ca2+/calmodulin-dependent protein phosphatase that plays a critical role in Ca2+ signaling.; Title: strong similarity to calcineurin responsive zinc-finger transcription factor Crz1 - Saccharomyces cerevisiae; nucleus; See PMID 9407035; See PMID 10197980; uncharacterized protein 98320 4986451 An13g00370 Aspergillus niger uncharacterized protein XP_059604585.1 96398 D 5061 CDS An13g00380 4986489 complement(join(99194..99588,99763..100219)) II 1 NT_166528.1 Title: similarity to hypothetical protein B12J7.160 - Neurospora crassa; uncharacterized protein 100219 4986489 An13g00380 Aspergillus niger uncharacterized protein XP_001396178.1 99194 R 5061 CDS An13g00390 4986486 complement(join(101080..101672,101726..102284)) II 1 NT_166528.1 Title: strong similarity to hypothetical protein EAA64232.1 - Aspergillus nidulans; uncharacterized protein 102284 4986486 An13g00390 Aspergillus niger uncharacterized protein XP_001396179.1 101080 R 5061 CDS An13g00400 4986472 join(102979..103001,103062..105798) II 1 NT_166528.1 Function: synthesis of trehalose in the yeast S. cerevisiae is catalysed by the trehalose-6-phosphate (Tre6P) synthase/phosphatase complex, which is composed of at least three different subunits encoded by the genes TPS1, TPS2, and TPS3; Tps1 and Tps2 carry the catalytic activities of trehalose synthesis, namely Tre6P synthase (Tps1) and Tre6P phosphatase (Tps2), while TPS3 has regulatory functions.; Remark: the TSL1 and TPS3 genes are identical.; Title: strong similarity to regulator subunit of trehalose-6-phosphate synthase/phosphatase complex Tps3 -Saccharomyces cerevisiae; See PMID 8850521; See PMID 9133641; See PMID 9194697; uncharacterized protein 105798 4986472 An13g00400 Aspergillus niger uncharacterized protein XP_001396180.3 102979 D 5061 CDS An13g00410 4986460 join(106517..106643,106701..107599,107817..107831) II 1 NT_166528.1 Title: strong similarity to hypothetical protein CAD28442.1 - Aspergillus fumigatus; uncharacterized protein 107831 4986460 An13g00410 Aspergillus niger uncharacterized protein XP_001396181.3 106517 D 5061 CDS An13g00420 4986490 complement(join(108023..108035,108044..>108318)) II 1 NT_166528.1 Remark: N-terminally truncated due to contig border.; Title: weak similarity to hypothetical protein encoded by An08g03040 - Aspergillus niger [truncated ORF]; uncharacterized protein 108318 4986490 An13g00420 Aspergillus niger uncharacterized protein XP_001396182.3 108023 R 5061 CDS An13g00430 4986491 108423..109550 II 1 NT_166528.1 Function: ACOB may be a gene that is required for sporulation only at elevated temperatures.; Phenotype: disruption of the acoB gene produces a strain that is thermosensitive for conidiation.; Title: similarity to pre-induction sporulation gene acoB - Aspergillus nidulans; See PMID 7551046; uncharacterized protein 109550 4986491 An13g00430 Aspergillus niger uncharacterized protein XP_001396183.1 108423 D 5061 CDS An13g00440 4986492 complement(110093..110731) II 1 NT_166528.1 Catalytic activity: URA6 catalyzes the conversion of ATP and UMP to ADP and UDP.; Remark: the alternate gene name for URA6 is SOC8.; Title: strong similarity to uridine-monophosphate kinase Ura6 - Saccharomyces cerevisiae; See PMID 2172245; See PMID 3025561; uncharacterized protein 110731 4986492 An13g00440 Aspergillus niger uncharacterized protein XP_001396184.1 110093 R 5061 CDS An13g00450 4986493 join(111857..112009,112056..113111) II 1 NT_166528.1 Title: weak similarity to hypothetical protein encoded by An08g00850 - Aspergillus niger; uncharacterized protein 113111 4986493 An13g00450 Aspergillus niger uncharacterized protein XP_001396185.3 111857 D 5061 CDS An13g00460 4986494 complement(join(113631..115235,115358..115522,115572..115661)) II 1 NT_166528.1 Title: strong similarity to hypothetical protein BAC67939.1 - Streptomyces avermitilis; uncharacterized protein 115661 4986494 An13g00460 Aspergillus niger uncharacterized protein XP_001396186.1 113631 R 5061 CDS An13g00470 84592788 join(116485..116637,116688..116957) II 1 NT_166528.1 hypothetical protein 116957 84592788 An13g00470 Aspergillus niger hypothetical protein XP_059602015.1 116485 D 5061 CDS An13g00480 10098170 complement(join(117748..119296,119356..119411,119518..119606,119991..120033,120363..120425,120531..120623)) II 1 NT_166528.1 Remark: the structure of Candida antarctica lipase B shows that the enzyme has a Ser-His-Asp catalytic triad in its active site.; Title: similarity to precursor of triacylglycerol lipase B - Candida antarctica; See PMID 8087556; uncharacterized protein 120623 10098170 An13g00480 Aspergillus niger uncharacterized protein XP_059602016.1 117748 R 5061 CDS An13g00490 84592789 join(121221..121451,121776..121850,121935..121972,122085..122184,122399..122512) II 1 NT_166528.1 hypothetical protein 122512 84592789 An13g00490 Aspergillus niger hypothetical protein XP_059602017.1 121221 D 5061 CDS An13g00500 84592790 complement(join(123034..123133,123247..123313,123390..123432,123783..123854,124170..124199,124368..124448,124673..124763,124854..124981,125332..125553)) II 1 NT_166528.1 hypothetical protein 125553 84592790 An13g00500 Aspergillus niger hypothetical protein XP_059602018.1 123034 R 5061 CDS An13g00510 4986499 125743..127317 II 1 NT_166528.1 Induction: expression of hxk1 increases strongly during growth in fructose or glycerol.; Remark: two hexokinases were characterized in Schizosaccharomyces pombe: hxk1, with a low phosphorylation coefficient on glucose (Km 8. 5 mM) and hxk2, a kinetically conventional hexokinase.; Title: strong similarity to hexokinase 1 hxk1p -Schizosaccharomyces pombe; cytoplasm; See PMID 8549830; uncharacterized protein 127317 4986499 An13g00510 Aspergillus niger uncharacterized protein XP_001396191.3 125743 D 5061 CDS An13g00520 4986500 complement(join(127977..128252,128433..128475,128590..129119)) II 1 NT_166528.1 Title: similarity to EST an_3235 - Aspergillus niger; uncharacterized protein 129119 4986500 An13g00520 Aspergillus niger uncharacterized protein XP_059602019.1 127977 R 5061 CDS An13g00530 84592791 complement(join(129339..129443,129551..129589)) II 1 NT_166528.1 hypothetical protein 129589 84592791 An13g00530 Aspergillus niger hypothetical protein XP_059602020.1 129339 R 5061 CDS An13g00540 4986502 join(129623..129947,130075..130547) II 1 NT_166528.1 Title: weak similarity to hypothetical major allergen Phl p 5 - Phleum pratense; uncharacterized protein 130547 4986502 An13g00540 Aspergillus niger uncharacterized protein XP_059602021.1 129623 D 5061 CDS An13g00550 4986503 complement(join(131367..132383,132544..132599,132663..132705)) II 1 NT_166528.1 Catalytic activity: aroF catalyzes the condensation of erythrose-4-phosphate (E4P) and phosphoenolpyruvate (PEP) to yield DAHP.; Pathway: 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase aroF catalyzes the first committed step of the shikimate pathway of the biosynthesis of aromatic amino acids.; Remark: aroF is inhibited by tyrosine.; Title: strong similarity to tyr-inhibited DAHP synthase aroF - Aspergillus nidulans; See PMID 11285739; uncharacterized protein 132705 4986503 An13g00550 Aspergillus niger uncharacterized protein XP_001396195.1 131367 R 5061 CDS An13g00560 4986504 complement(join(135156..135772,135825..136081,136400..136430,136460..136469)) II 1 NT_166528.1 Function: the csgA mutations of M. xanthus inhibit sporulation as well as rippling; Localization: most of csgA protein in M. xanthus is associated with the extracellular matrix.; Title: similarity to developmental protein C-factor csgA - Myxococcus xanthus; See PMID 1372277; See PMID 2118510; See PMID 2542221; uncharacterized protein 136469 4986504 An13g00560 Aspergillus niger uncharacterized protein XP_001396196.3 135156 R 5061 CDS An13g00570 84592792 join(137052..137129,137196..138026) II 1 NT_166528.1 Title: weak similarity to dentin phosphoprotein precursor DPP - Rattus norvegicus; uncharacterized protein 138026 84592792 An13g00570 Aspergillus niger uncharacterized protein XP_059602022.1 137052 D 5061 CDS An13g00580 84592793 complement(join(138284..138346,138430..138682,138729..138811)) II 1 NT_166528.1 hypothetical protein 138811 84592793 An13g00580 Aspergillus niger hypothetical protein XP_059602023.1 138284 R 5061 CDS An13g00590 4986507 138964..140205 II 1 NT_166528.1 Induction: POT1 is induced approximately 30-fold when oleate is the carbon source.; Phenotype: disruption of POT1 abolishes the ability of Y. lipolytica cells to grow on solid media with oleate as a carbon source.; Title: strong similarity to peroxisomal acetyl-CoA C-acyltransferase POT1 - Yarrowia lipolytica; peroxisome; See PMID 7916689; uncharacterized protein 140205 4986507 An13g00590 Aspergillus niger uncharacterized protein XP_001396199.1 138964 D 5061 CDS An13g00600 4986508 join(140460..140551,140620..141246,141323..141773,141851..>142062) II 1 NT_166528.1 Remark: C-terminally truncated due to contig border.; Title: weak similarity to hypothetical protein Rv3439c - Mycobacterium tuberculosis [truncated ORF]; uncharacterized protein 142062 4986508 An13g00600 Aspergillus niger uncharacterized protein XP_001396200.3 140460 D 5061 CDS An13g00610 4986509 complement(join(142199..142666,142724..143201,143270..143289)) II 1 NT_166528.1 Title: similarity to human secreted protein with SEQ ID NO:128 from patent WO200061627-A - Homo sapiens; extracellular/secretion proteins; uncharacterized protein 143289 4986509 An13g00610 Aspergillus niger uncharacterized protein XP_001396201.1 142199 R 5061 CDS An13g00620 4986510 join(143580..143688,143826..144773,144833..145482) II 1 NT_166528.1 Function: G19P1 is an acidic phosphoprotein that is a substrate for protein kinase C in fibroblasts and epidermal carcinoma cells.; Title: strong similarity to 80K protein H precursor G19P1 - Homo sapiens; See PMID 2793184; uncharacterized protein 145482 4986510 An13g00620 Aspergillus niger uncharacterized protein XP_059602024.1 143580 D 5061 CDS An13g00630 84592794 join(147627..147692,147742..147876) II 1 NT_166528.1 Remark: Metallothioneins (MTs) may play key roles because of their preferential binding to zinc especially in ageing.; Title: similarity to protein CAP5 - Colletotrichum gloeosporioides; See PMID 11707929; uncharacterized protein 147876 84592794 An13g00630 Aspergillus niger uncharacterized protein XP_059602025.1 147627 D 5061 CDS An13g00640 4986512 149493..150545 II 1 NT_166528.1 Title: weak similarity to hypothetical protein PA4177 - Pseudomonas aeruginosa; uncharacterized protein 150545 4986512 An13g00640 Aspergillus niger uncharacterized protein XP_001396204.1 149493 D 5061 CDS An13g00650 4986513 join(151082..151635,151665..152376,152433..153011) II 1 NT_166528.1 Function: S. cerevisiae TRF5 is required for the establishment of cohesion between sister chromatids, which is coupled to replication fork passage.; Function: S. cerevisiae Trf4 and Trf5 represent the fourth class of essential nuclear DNA polymerases (designated DNA polymerase kappa) and provide a key link in the coordination between DNA replication and sister chromatid cohesion.; Similarity: S. cerevisiae TRF5 and TRF4 are redundant homologs as shown by the viability of single, but lethality of double mutants.; Title: similarity to DNA polymerase kappa Trf5 -Saccharomyces cerevisiae; nucleus; See PMID 10926539; uncharacterized protein 153011 4986513 An13g00650 Aspergillus niger uncharacterized protein XP_059602026.1 151082 D 5061 CDS An13g00660 4986514 complement(154102..155493) II 1 NT_166528.1 Catalytic activity: L-fucose dehydrogenase converts a D-threo-aldose + NADP(+) to a D-threo-aldono-1,5-lactone + NADPH.; Function: Pseudomonas FDH is involved in carbohydrate utilisation.; Function: Pseudomonas FDH is specific to NADP+ as a hydrogen acceptor.; Title: similarity to L-fucose dehydrogenase FDH -Pseudomonas sp.; uncharacterized protein 155493 4986514 An13g00660 Aspergillus niger uncharacterized protein XP_001396206.1 154102 R 5061 CDS An13g00670 4986515 complement(join(156439..156843,156949..156951)) II 1 NT_166528.1 Function: S. cerevisiae MIA1 is a mitochondrial protein of unknown function and mia1 mutations lead to respiratory defects.; Remark: information regarding S. cerevisiae MIA1 has not yet been published and is available from http://genome-www. stanford. edu/cgi-bin/SGD/genehunter.; Remark: the systematic name for S. cerevisiae MIA1 is YJL104w.; Title: strong similarity to mitochondrial protein Mia1 - Saccharomyces cerevisiae; localisation:mitochondrion; uncharacterized protein 156951 4986515 An13g00670 Aspergillus niger uncharacterized protein XP_001396207.1 156439 R 5061 CDS An13g00680 4986516 join(157776..157788,157918..159113,159183..159812) II 1 NT_166528.1 Function: Y. lipolytica PEX23 is involved in peroxisomal biogenesis, especially concerning import of peroxisomal proteins.; Function: Y. lipolytica pex23 mutants lack morphologically recognizable peroxisomes and mislocalize all peroxisomal matrix proteins investigated preferentially to the cytosol.; Function: Y. lipolytica pex23 strains accumulate vesicles that contain both peroxisomal matrix and membrane proteins.; Remark: the EMBL entry for PEX22 likely is a typing error and contains a protein sequence identical to the Genbank entry for PEX23.; Title: strong similarity to integral peroxisomal membrane protein PEX23 - Yarrowia lipolytica; peroxisome; See PMID 10637297; uncharacterized protein 159812 4986516 An13g00680 Aspergillus niger uncharacterized protein XP_001396208.1 157776 D 5061 CDS An13g00690 4986517 complement(join(160052..160132,160260..160704,160760..160960,161015..161827,161890..162020)) II 1 NT_166528.1 Similarity: similarity is between the N-terminal halfs of the predicted A. niger protein and N. crassa acr-2, which include the fungal GAL4-type Zn(II)Cys6 binuclear DNA-binding domain.; Title: similarity to transcription factor involved in acriflavine resistance acr-2 - Neurospora crassa; nucleus; See PMID 8679704; uncharacterized protein 162020 4986517 An13g00690 Aspergillus niger uncharacterized protein XP_001396209.3 160052 R 5061 CDS An13g00700 84592795 complement(join(162698..162828,162917..>163049)) II 1 NT_166528.1 Remark: ORF 5'truncated due to end of contig.; hypothetical protein [truncated ORF] 163049 84592795 An13g00700 Aspergillus niger hypothetical protein [truncated ORF] XP_059602027.1 162698 R 5061 CDS An13g00710 4986519 join(163302..163643,163700..164279,164334..165242,165327..165562) II 1 NT_166528.1 Catalytic activity: RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).; Induction: AO-I is highly expressed in A. niger grown on n-butylamine as a single nitrogen source.; Localization: AO-I is located in the cell wall and probably serves primarily as a detoxifying agent,preventing amines from entering and damaging the cell.; Remark: the AO-I aa sequence deviates significantly from the genomic sequence and therefore the two enzymes are probably isoenzymes.; Similarity: AO-I belongs to the copper/topaquinone oxidase family.; Title: strong similarity to copper amine oxidase AO-I - Aspergillus niger; cell wall; See PMID 8620882; See PMID 10896215; uncharacterized protein 165562 4986519 An13g00710 Aspergillus niger uncharacterized protein XP_001396211.1 163302 D 5061 CDS An13g00720 4986520 join(166073..166578,166659..167631) II 1 NT_166528.1 Remark: the expression of FLU1 mediated not only resistance to fluconazole but also to cycloheximide.; Title: similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353; uncharacterized protein 167631 4986520 An13g00720 Aspergillus niger uncharacterized protein XP_001396212.1 166073 D 5061 CDS An13g00730 4986521 complement(join(168124..169365,169416..169868,169985..170334,170388..170394)) II 1 NT_166528.1 Function: Cha4p is a positive regulator of CHA1 transcription that is binding UASCHA alone or as part of a complex.; Function: Cha4p of S. cerevisiae activates transcription via serine/threonine response elements in the CHA1 promoter, UASCHA.; Remark: the CHA1 gene of S. cerevisiae encodes the catabolic L-serine (L-threonine) deaminase responsible for the utilization of serine/threonine as nitrogen sources.; Similarity: Cha4p belongs to the superfamily of unassigned GAL4-type zinc cluster proteins.; Title: similarity to transcription activator Cha4 -Saccharomyces cerevisiae; nucleus; See PMID 8889513; uncharacterized protein 170394 4986521 An13g00730 Aspergillus niger uncharacterized protein XP_059602028.1 168124 R 5061 CDS An13g00740 4986522 complement(join(171093..171302,171369..172120,172193..172679,172801..172905)) II 1 NT_166528.1 Catalytic activity: CFA synthase catalyzes the transfer of a methylene from S-adenosyl-L-methionine to an unsaturated fatty acid to form a cyclopropyl fatty acid and S-adenosyl-L-homocysteine.; Function: CFA synthase of Escherichia coli catalyzes a modification of the acyl chains of phospholipid bilayers.; Title: similarity to cyclopropane-fatty-acyl-phospholipid synthase - Escherichia coli; See PMID 1445840; uncharacterized protein 172905 4986522 An13g00740 Aspergillus niger uncharacterized protein XP_001396214.1 171093 R 5061 CDS An13g00750 4986523 complement(join(174214..174974,175041..175277,175364..175616)) II 1 NT_166528.1 Title: similarity to hypothetical protein CAD21416.1 - Neurospora crassa; uncharacterized protein 175616 4986523 An13g00750 Aspergillus niger uncharacterized protein XP_059602029.1 174214 R 5061 CDS An13g00760 4986524 join(176190..176207,176411..176715,176817..176979) II 1 NT_166528.1 Function: tropomyosin, and by inference actin cables, may facilitate directed vesicular transport of components to the correct location on the cell surface.; Localization: indirect immunofluorescence microscopy reveals that tropomyosin is localized with actin cables in wild-type cells.; Phenotype: disruption of TPM1 results in the disappearance of actin cables from the cytoskeleton and in a reduced growth rate.; Remark: TPM1 encodes the major form of tropomyosin in yeast.; Title: strong similarity to tropomyosin Tpm1 -Saccharomyces cerevisiae; cytoskeleton; See PMID 2649250; See PMID 1629236; uncharacterized protein 176979 4986524 An13g00760 Aspergillus niger uncharacterized protein XP_001396216.1 176190 D 5061 CDS An13g00770 4986525 complement(join(177328..177816,177883..178062)) II 1 NT_166528.1 Title: strong similarity to hypothetical protein CAD21418.1 - Neurospora crassa; uncharacterized protein 178062 4986525 An13g00770 Aspergillus niger uncharacterized protein XP_001396217.1 177328 R 5061 CDS An13g00780 4986526 join(178359..178453,178518..178816,178881..178985,179042..179263,179318..179457) II 1 NT_166528.1 Title: strong similarity to hypothetical protein CAD21419.1 - Neurospora crassa; uncharacterized protein 179457 4986526 An13g00780 Aspergillus niger uncharacterized protein XP_001396218.1 178359 D 5061 CDS An13g00790 4986527 join(180221..181256,181404..181434,181505..181587,181688..181861,181951..182064,182102..182323,182617..183416) II 1 NT_166528.1 Title: similarity to CSI2 like protein CAC28732.1 -Neurospora crassa; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942; uncharacterized protein 183416 4986527 An13g00790 Aspergillus niger uncharacterized protein XP_001396219.3 180221 D 5061 CDS An13g00793 4986528 complement(join(183577..183597,183692..183741,183821..183905)) II 1 NT_166528.1 hypothetical protein 183905 4986528 An13g00793 Aspergillus niger hypothetical protein XP_059602030.1 183577 R 5061 CDS An13g00800 4986529 184575..185711 II 1 NT_166528.1 Function: It is proposed that Per8p is a component of the molecular machinery that controls the proliferation of peroxisomes.; Induction: in the methylotrophic yeast Hansenula polymorpha the formation of peroxisomes is induced in methanol or methylamine medium.; Localization: Per8p is an integral membrane protein of the peroxisome that is concentrated in the membranes of newly formed organelles.; Phenotype: PER8 mutant cells contain no peroxisome-like structures and peroxisomal enzymes are located in the cytosol.; Remark: Hansenula polymorpha and Pichia angusta are synonymous names referring to the same organism.; Title: strong similarity to peroxisomal integral membrane protein Per8p - Pichia angusta; peroxisome; See PMID 7844145; uncharacterized protein 185711 4986529 An13g00800 Aspergillus niger uncharacterized protein XP_001396221.1 184575 D 5061 CDS An13g00810 4986530 complement(join(186103..186281,186341..187335,187426..187509,187561..187589)) II 1 NT_166528.1 Title: weak similarity to RecQ-type DNA helicase WRN - Mus musculus; uncharacterized protein 187589 4986530 An13g00810 Aspergillus niger uncharacterized protein XP_001396222.3 186103 R 5061 CDS An13g00820 4986531 join(188302..188350,188415..188442,188552..188615,188682..188720) II 1 NT_166528.1 Title: similarity to protein fragment SEQ ID NO:23725 from patent EP1033405-A - Zea mays; uncharacterized protein 188720 4986531 An13g00820 Aspergillus niger uncharacterized protein XP_001396223.3 188302 D 5061 CDS An13g00830 84592796 complement(join(190500..190672,191080..191150,191247..191368,191450..191498,191575..191772,191998..192200,192402..192457,192845..192919,192974..193049)) II 1 NT_166528.1 hypothetical protein 193049 84592796 An13g00830 Aspergillus niger hypothetical protein XP_059602031.1 190500 R 5061 CDS An13g00840 4986533 join(194523..194799,194873..195290,195356..196418) II 1 NT_166528.1 Function: GAP1 is the general amino acid permease gene of S. cerevisiae that catalyses active transport of apparently all biological amino acids across the plasma membrane.; Induction: GAP1 activity is regulated according to nitrogen source, the activity being high on urea and low on glutamate; this regulation is due to differential protein sorting from the Golgi complex to either the plasma membrane or the vacuole.; Phenotype: mutations at the GAP1 locus selectively abolish the activity of the general amino acid transport system.; Title: strong similarity to general amino acid permease Gap1 - Saccharomyces cerevisiae; plasma membrane; See PMID 8636059; See PMID 2194797; uncharacterized protein 196418 4986533 An13g00840 Aspergillus niger uncharacterized protein XP_001396225.1 194523 D 5061 CDS An13g00850 4986534 join(197991..198221,198292..199435,199493..199588,199644..199829,199874..200871) II 1 NT_166528.1 Title: strong similarity to hypothetical Rho GTPase protein - Schizosaccharomyces pombe; uncharacterized protein 200871 4986534 An13g00850 Aspergillus niger uncharacterized protein XP_059602032.1 197991 D 5061 CDS An13g00860 4986535 complement(join(201862..202391,202485..203456,203507..203767,203840..203891)) II 1 NT_166528.1 Function: the cdc18 protein is required both for initiation of DNA replication and for coupling mitosis to the completion of S phase.; Induction: transcription of CDC18+ is activated by the transcriptional activator cdc10+ during passage through START.; Remark: cdc18 is a highly unstable protein that is expressed only once per cell cycle at the boundary between G1 and S phase.; Title: strong similarity to cell division control protein cdc18p - Schizosaccharomyces pombe; See PMID 7916658; See PMID 8643672; uncharacterized protein 203891 4986535 An13g00860 Aspergillus niger uncharacterized protein XP_059602033.1 201862 R 5061 CDS An13g00870 4986536 join(204651..205137,205206..206269) II 1 NT_166528.1 Title: strong similarity to protein fragment SEQ ID NO:55236 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 206269 4986536 An13g00870 Aspergillus niger uncharacterized protein XP_001396228.1 204651 D 5061 CDS An13g00880 84592797 complement(join(206591..206674,206737..206958)) II 1 NT_166528.1 hypothetical protein 206958 84592797 An13g00880 Aspergillus niger hypothetical protein XP_059602034.1 206591 R 5061 CDS An13g00890 4986538 join(207595..207646,207720..207750,207839..208155,208214..209868) II 1 NT_166528.1 Function: severin kinase is a kinase from cytosolic extracts that specifically phosphorylates severin, a Ca2+-dependent F-actin fragmenting protein.; Pathway: the presence of severin kinase in Dictyostelium suggests a direct signal transduction from the plasma membrane to the cytoskeleton by phosphorylation of actin-binding proteins.; Similarity: severin kinase belongs to the Ste20p- or p21-activated protein kinase family.; Title: strong similarity to severin kinase -Dictyostelium discoideum; See PMID 9582328; uncharacterized protein 209868 4986538 An13g00890 Aspergillus niger uncharacterized protein XP_059602035.1 207595 D 5061 CDS An13g00910 4986539 complement(join(211009..211804,211871..213239,213292..213408,213489..213502,213663..213850)) II 1 NT_166528.1 Function: FacB/acuB is a major regulatory gene involved in acetamide and acetate utilisation.; Phenotype: acuB mutants are unable to grow on acetate as a sole carbon source due to lack of both ACS (acetyl-CoA synthetase) and isocitrate lyase activity.; Similarity: acuB is analogous to the A. nidulans facB regulatory gene.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus niger; See PMID 9197408; See PMID 10483720; uncharacterized protein 213850 4986539 An13g00910 Aspergillus niger uncharacterized protein XP_059602036.1 211009 R 5061 CDS An13g00920 4986540 join(214527..214613,214674..214896,214962..215920) II 1 NT_166528.1 Function: mandelate racemase enables Pseudomonas to utilize (R)-mandelate as sole carbon source.; Title: similarity to mandelate racemase -Pseudomonas putida; See PMID 2831968; uncharacterized protein 215920 4986540 An13g00920 Aspergillus niger uncharacterized protein XP_001396232.1 214527 D 5061 CDS An13g00930 4986541 join(216362..216430,216504..216787,216884..217358) II 1 NT_166528.1 Remark: gdhIII is one of four glucose dehydrogenase genes have been cloned from B. megaterium IAM1030.; Title: strong similarity to glucose 1-dehydrogenase gdhIII - Bacillus megaterium; See PMID 1629157; uncharacterized protein 217358 4986541 An13g00930 Aspergillus niger uncharacterized protein XP_001396233.3 216362 D 5061 CDS An13g00940 4986542 complement(217524..218705) II 1 NT_166528.1 Title: strong similarity to hypothetical protein CAD21281.1 - Neurospora crassa; uncharacterized protein 218705 4986542 An13g00940 Aspergillus niger uncharacterized protein XP_059602037.1 217524 R 5061 CDS An13g00950 4986543 join(219688..219845,219934..219982,220033..220189,220254..221023) II 1 NT_166528.1 Title: strong similarity to alcohol dehydrogenase alcB - Aspergillus nidulans; See PMID 8821658; uncharacterized protein 221023 4986543 An13g00950 Aspergillus niger uncharacterized protein XP_001396235.1 219688 D 5061 CDS An13g00970 4986545 complement(join(222934..223896,223986..224098,224138..224393)) II 1 NT_166528.1 Title: weak similarity to heat shock protein groEL -Streptococcus pyogenes; uncharacterized protein 224393 4986545 An13g00970 Aspergillus niger uncharacterized protein XP_059602038.1 222934 R 5061 CDS An13g00980 4986546 complement(join(226653..230048,230126..230482)) II 1 NT_166528.1 Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942; uncharacterized protein 230482 4986546 An13g00980 Aspergillus niger uncharacterized protein XP_059602039.1 226653 R 5061 CDS An13g00990 4986547 231700..234162 II 1 NT_166528.1 hypothetical protein 234162 4986547 An13g00990 Aspergillus niger hypothetical protein XP_001396238.1 231700 D 5061 CDS An13g01000 4986548 complement(join(234809..235695,235751..236381)) II 1 NT_166528.1 Similarity: weak similarity to PATENTPROT entry GENESEQPROT:W71368 (H. sapiens DAP3 protein).; Similarity: weak similarity to hypothetical protein SPBC29A3. 15c of S. pombe.; Title: weak similarity to death associated protein DAP3 from patent WO9839429-A2 - Homo sapiens; mitochondrial 37S ribosomal protein mS29 236381 4986548 An13g01000 Aspergillus niger mitochondrial 37S ribosomal protein mS29 XP_001396239.1 234809 R 5061 CDS An13g01010 4986549 join(236788..236825,236938..237538) II 1 NT_166528.1 Title: strong similarity to hypothetical protein YOR294w - Saccharomyces cerevisiae; uncharacterized protein 237538 4986549 An13g01010 Aspergillus niger uncharacterized protein XP_001396240.1 236788 D 5061 CDS An13g01020 4986550 complement(join(238643..239349,239407..239501,239557..240226,240285..240862,241048..241282,241543..241573)) II 1 NT_166528.1 Function: RhoGAPs stimulate the activity of Rho-type GTPases.; Pathway: Rho-type GTPases mediate signalling pathways involved in cytoskeleton organization, cell polarization, cell growth and development etc.; Remark: BEM2 of S. cerevisiae is also known as IPL2,SUP9 or TSL1.; Remark: the sytematic gene name of BEM2 of S. cerevisiae is YER155c.; Similarity: the similarity to RhoGAPs of diverse species covers only the GTPase activation domain located in the C-terminal part.; Title: similarity to Rho-type GTPase activating protein Bem2 - Saccharomyces cerevisiae; See PMID 7962097; See PMID 7962098; uncharacterized protein 241573 4986550 An13g01020 Aspergillus niger uncharacterized protein XP_059602040.1 238643 R 5061 CDS An13g01030 84592798 complement(join(242817..243254,243384..243431)) II 1 NT_166528.1 hypothetical protein 243431 84592798 An13g01030 Aspergillus niger hypothetical protein XP_059602041.1 242817 R 5061 CDS An13g01040 4986552 join(245067..245165,245237..245974,246027..246151,246209..246251) II 1 NT_166528.1 Catalytic activity: heterotrimeric RABGGT of H. sapiens (alpha1beta1 component B + Rab escort protein, also called component A) catalyzes the transfer of geranylgeranyl (a 20-carbon isoprenoid group) from geranylgeranyl pyrophosphate to both cysteines in Rab proteins with an -xxCC, -xCxC and -CCxx C-terminus.; Function: RABGGTB of H. sapiens is the beta subunit of the heterodimeric (alpha1beta1) catalytic component of Rab geranylgeranyl transferase (RABGGT).; Pathway: Rab GTP-binding proteins modified by RABGGT play an important role in vesicular traffic regulation, eg the control of exocytosis in neuroendocrine and neuronal cells of human brain.; Title: strong similarity to geranylgeranyl transferase type II beta-subunit RABGGTB - Homo sapiens; cytoplasm; See PMID 8706741; See PMID 1525821; uncharacterized protein 246251 4986552 An13g01040 Aspergillus niger uncharacterized protein XP_001396243.1 245067 D 5061 CDS An13g01050 4986553 247533..249350 II 1 NT_166528.1 Title: strong similarity to acvA gene expression regulator Pc804 from patent WO200257456-A2 - Unclassified organism; uncharacterized protein 249350 4986553 An13g01050 Aspergillus niger uncharacterized protein XP_001396244.1 247533 D 5061 CDS An13g01060 4986554 join(250040..250793,250912..251996,252057..253532) II 1 NT_166528.1 Function: swi4 of S. pombe is involved in termination of copy-synthesis during mating-type switching.; Similarity: strong similarity to DNA mismatch repair proteins of the mutS family from diverse species.; Title: strong similarity to mating-type switching protein swi4p - Schizosaccharomyces pombe; nucleus; See PMID 1317550; uncharacterized protein 253532 4986554 An13g01060 Aspergillus niger uncharacterized protein XP_059602042.1 250040 D 5061 CDS An13g01070 4986555 complement(join(254284..254345,254743..254826,254963..255023)) II 1 NT_166528.1 Complex: RPS28B (RPS33B) in S. cerevisiae forms part of the 40S ribosomal subunit.; Remark: the systematic gene name of RPS28B (RPS33B) from S. cerevisiae is YLR264W.; Title: strong similarity to 40S ribosomal protein S28.e.B RPS 28B Rps33b - Saccharomyces cerevisiae; cytoplasm; See PMID 6196722; 40S ribosomal protein eS28 255023 4986555 An13g01070 Aspergillus niger 40S ribosomal protein eS28 XP_001396246.1 254284 R 5061 CDS An13g01080 4986556 join(255586..255602,255695..255729,255844..256341,256405..256542,256610..256845) II 1 NT_166528.1 Catalytic activity: ATP phosphoribosyltransferase (EC 2. 4. 2. 17) catalyzes the transfer of 5-phospho-D-ribosyl from 5-phospho-D-ribosyl-1-diphosphate to N1 of ATP.; Function: ATP phosphoribosyltransferase in S. cerevisiae is allosterically regulated.; Pathway: ATP phosphoribosyltransferase in S. cerevisiae catalyzes the initial step in histidine biosynthesis.; Remark: his1 of S. pombe complements HIS1 deficiency in S. cerevisiae.; Remark: possible sequencing error at position 28102 or unusual splicing donor site (GC instead of GT).; Similarity: also strong similarity to ATP phosphoribosyltransferase HIS1 of S. cerevisiae.; Title: strong similarity to ATP phosphoribosyltransferase his1p - Schizosaccharomyces pombe [putative sequencing error]; See PMID 7844145; See PMID 385447; uncharacterized protein 256845 4986556 An13g01080 Aspergillus niger uncharacterized protein XP_001396247.1 255586 D 5061 CDS An13g01090 4986557 complement(257869..260490) II 1 NT_166528.1 Title: strong similarity to hypothetical protein YJR098c - Saccharomyces cerevisiae; uncharacterized protein 260490 4986557 An13g01090 Aspergillus niger uncharacterized protein XP_001396248.1 257869 R 5061 CDS An13g01100 84592799 join(260590..260670,260740..260897,261021..261102,261196..261249,261302..261370,261530..261625) II 1 NT_166528.1 hypothetical protein 261625 84592799 An13g01100 Aspergillus niger hypothetical protein XP_059602043.1 260590 D 5061 CDS An13g01110 4986559 complement(join(262059..262205,262303..262956)) II 1 NT_166528.1 Title: similarity to hypothetical protein encoded by An14g05070 - Aspergillus niger; uncharacterized protein 262956 4986559 An13g01110 Aspergillus niger uncharacterized protein XP_001396250.1 262059 R 5061 CDS An13g01120 4986560 join(263686..264516,264567..264806) II 1 NT_166528.1 Catalytic activity: LB4D in H. sapiens catalyzes the conversion of leukotriene B4 into 12-oxo-leukotriene B4.; Catalytic activity: LB4D in H. sapiens requires NADP as a cofactor.; Pathway: LB4D in H. sapiens catalyzes the initial and key step of metabolic inactivation of leukotriene B4.; Similarity: LB4D of H. sapiens is homologous to 15-oxoprostaglandin 13-reductase of Sus scrofa (pig) and dithiolethione-inducible gene-1 of Rattus norvegicus (rat).; Similarity: also shows strong similarity to hypothetical quinone oxidoreductases and allyl-alcohol dehydrogenases of various species.; Title: strong similarity to NADP-dependent leukotriene B4 12-hydroxydehydrogenase LB4D - Homo sapiens; See PMID 8576264; See PMID 9461497; See PMID 9667737; uncharacterized protein 264806 4986560 An13g01120 Aspergillus niger uncharacterized protein XP_001396251.1 263686 D 5061 CDS An13g01130 4986561 join(265308..265368,265456..266279) II 1 NT_166528.1 Catalytic activity: RhlG in P. aeruginosa catalyzes the reduction of 3-oxodecanoyl-ACP to 3-hydroxydecanoyl-ACP.; Pathway: RhlG in P. aeruginosa is specifically involved in the biosynthesis of rhamnolipids.; Similarity: RhlG in P. aeruginosa is homologous to 3-oxoacyl-(acyl-carrier-protein) reductase FabG.; Similarity: shows similarity to 3-oxoacyl-(acyl-carrier-protein) reductases of various species.; Title: strong similarity to NADPH-dependent beta-ketoacyl reductase RhlG - Pseudomonas aeruginosa; See PMID 9721281; uncharacterized protein 266279 4986561 An13g01130 Aspergillus niger uncharacterized protein XP_001396252.1 265308 D 5061 CDS An13g01140 84592800 complement(join(266336..266449,266514..266685,266716..266856,266989..267761)) II 1 NT_166528.1 Catalytic activity: serine/threonine-specific protein kinases catalyze the transfer of a phosphate group from ATP to the hydroxyl group of serine or threonine.; Function: Hal4 in S. cerevisiae presumably acts together with Hal5 to activate the Trk1-Trk2 potassium transporter.; Pathway: Hal4 in S. cerevisiae is involved in the coordinate regulation of potassium transport and electrical membrane potential.; Remark: HAL4 of S. cerevisiae is also called SAT4.; Remark: the systematic gene name of HAL4 of S. cerevisiae is YCR008w.; Similarity: the homology covers only the C-terminal part of Hal4 from S. cerevisiae and other serine/threonine-specific protein kinases.; Title: similarity to serine/threonine-specific protein kinase Hal4 - Saccharomyces cerevisiae; See PMID 10207057; uncharacterized protein 267761 84592800 An13g01140 Aspergillus niger uncharacterized protein XP_059602044.1 266336 R 5061 CDS An13g01150 4986563 complement(join(268673..269269,269319..269773,269821..271015)) II 1 NT_166528.1 Function: probable GTPase-activator protein of Rab-like small GTPases (Rab-GAP).; Localization: drainin in D. discoideum is a peripheral membrane protein associated with the cytoplasmic phase of the vacuolar membrane.; Pathway: drainin in D. discoideum presumably mediates the volume-sensing of the contractile vacuole,leading to the formation of a water discharge channel between the contractile vacuole and the plasma membrane.; Similarity: only the central part shows homology to drainin of D. discoideum and other Rab-GAP-like proteins.; Title: similarity to drainin phgA - Dictyostelium discoideum; See PMID 10369671; uncharacterized protein 271015 4986563 An13g01150 Aspergillus niger uncharacterized protein XP_001396254.3 268673 R 5061 CDS An13g01160 10098166 complement(join(273314..275224,275276..275469,275722..276024,276074..276343,276395..276713,276779..277234)) II 1 NT_166528.1 Function: telomerase trt1 is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes by means of elongating telomeres.; Remark: Trt1 deletion causes telomere shortening and senescence.; Remark: telomerase trt1 is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.; Similarity: Trt1 belongs to the reverse transcriptase family.; Title: strong similarity to telomerase catalytic chain trt1p - Schizosaccharomyces pombe; nucleus; See PMID 9252327; See PMID 9467843; uncharacterized protein 277234 10098166 An13g01160 Aspergillus niger uncharacterized protein XP_059602045.1 273314 R 5061 CDS An13g01170 84592801 complement(join(278745..278893,279120..279341,280012..280155,280635..280906,281025..281073,281128..281169,281265..281334)) II 1 NT_166528.1 hypothetical protein 281334 84592801 An13g01170 Aspergillus niger hypothetical protein XP_059602046.1 278745 R 5061 CDS An13g01180 4986566 join(282726..287351,287422..288612) II 1 NT_166528.1 Remark: MyoM from D. discoideum is the first known unconventional myosin containing an active Rac-GEF domain.; Title: similarity to unconventional myosin heavy chain MyoM - Dictyostelium discoideum; cytoskeleton; See PMID 10828443; See PMID 11208126; uncharacterized protein 288612 4986566 An13g01180 Aspergillus niger uncharacterized protein XP_059602047.1 282726 D 5061 CDS An13g01190 4986567 join(289706..289762,289855..289882,289953..289967,290052..290101,290173..290192,290259..290810,290883..290931) II 1 NT_166528.1 Function: the S. cerevisiae Ulp1 protein is a Ubl-specific protease, that cleaves proteins from Smt3 and SUMO-1 but not from ubiquitin.; Remark: protein function can be modulated by ligation to ubiquitin or to ubiquitin-like proteins. SUMO-1 (vertebrates) and Smt3 (S. cerevisiae) are ubiquitin-like proteins (Ubl proteins), they are ligated to cellular proteins. this protein conjugation of SUMO-1/Smt3 to other proteins is involved in many physiological processes.; Remark: yeast Ulp1 has several functions, including an essential role in the G2/M phase of the cell cycle.; Similarity: the hypothetical protein YPL020c of S. cerevisiae is Ubl (ubiquitin-like protein) specific protease 1 (Ulp1p).; Title: similarity to cysteine-type peptidase Ulp1 -Saccharomyces cerevisiae; See PMID 10094048; uncharacterized protein 290931 4986567 An13g01190 Aspergillus niger uncharacterized protein XP_059602048.1 289706 D 5061 CDS An13g01200 4986568 join(292729..293720,293909..293962,294265..294397,294464..294523) II 1 NT_166528.1 Title: similarity to insulin receptor substrate protein xIRS-u - Xenopus laevis; See PMID 9717835; uncharacterized protein 294523 4986568 An13g01200 Aspergillus niger uncharacterized protein XP_001396259.3 292729 D 5061 CDS An13g01210 4986569 complement(join(296942..297266,297326..297600)) II 1 NT_166528.1 Function: pre3 is a subunit of the 20S proteasome involved in ubiquitin-dependent protein degradation.; Remark: pre3 of S. cerevisiae is a subunit necessary or hydrolysis of peptidylglutamyl-peptide.; Title: strong similarity to proteasome 20S subunit Pre3 - Saccharomyces cerevisiae; cytoplasm; See PMID 9677364; uncharacterized protein 297600 4986569 An13g01210 Aspergillus niger uncharacterized protein XP_001396260.3 296942 R 5061 CDS An13g01220 4986570 join(298378..298471,298536..299320) II 1 NT_166528.1 Title: strong similarity to hypothetical suppressor of bem1/bud5 bem46p - Schizosaccharomyces pombe; plasma membrane; uncharacterized protein 299320 4986570 An13g01220 Aspergillus niger uncharacterized protein XP_059602049.1 298378 D 5061 CDS An13g01230 4986571 join(303431..303451,303547..303669,303860..305296) II 1 NT_166528.1 Title: weak similarity to colon cancer antigen protein SEQ ID NO:4503 from patent WO200122920-A2 - Homo sapiens; uncharacterized protein 305296 4986571 An13g01230 Aspergillus niger uncharacterized protein XP_001396262.1 303431 D 5061 CDS An13g01240 4986572 306031..309507 II 1 NT_166528.1 Function: the human cysteine-rich transcription factor NF-X1 is a repressor of HLA-DRA transcription. It binds to the X-box motif of class II MHC genes and may play an important role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by interferon-gamma.; Similarity: the ORF DNA sequence also shows strong similarity to the EST an_1974 from Aspergillus niger.; Title: strong similarity to cysteine-rich transcription factor NF-X1 - Homo sapiens; See PMID 7964459; uncharacterized protein 309507 4986572 An13g01240 Aspergillus niger uncharacterized protein XP_059602050.1 306031 D 5061 CDS An13g01250 10098172 join(311467..311738,311801..312414,312465..313402) II 1 NT_166528.1 Function: S. cerevisiae is able to use the bacterial hydroxamate siderophore enterobactin as natural iron source. A enb1 null mutant looses this ability to import 55Fe-enterobactin.; Remark: alternate names for S. cerevisiae Enb1: Arn4 or YOL158C.; Similarity: the S. cerevisiae Enb1 protein belongs to the major facilitator super family (MFS).; Title: strong similarity to siderophore-iron transporter for enterobactin Enb1 - Saccharomyces cerevisiae; See PMID 10831226; uncharacterized protein 313402 10098172 An13g01250 Aspergillus niger uncharacterized protein XP_059602051.1 311467 D 5061 CDS An13g01260 4986574 join(313737..314830,314884..315420,315657..316192,316360..316394) II 1 NT_166528.1 Title: similarity to 1,2-alpha-D-mannosidase aman2 -Bacillus sp.; See PMID 8149382; uncharacterized protein 316394 4986574 An13g01260 Aspergillus niger uncharacterized protein XP_059602052.1 313737 D 5061 CDS An13g01270 4986575 complement(join(316683..317517,317570..319074)) II 1 NT_166528.1 Title: strong similarity to hypothetical protein B11A5.10 - Neurospora crassa; uncharacterized protein 319074 4986575 An13g01270 Aspergillus niger uncharacterized protein XP_059602053.1 316683 R 5061 CDS An13g01280 4986576 complement(320136..321968) II 1 NT_166528.1 Title: strong similarity to hypothetical protein EAA64035.1 - Aspergillus nidulans; uncharacterized protein 321968 4986576 An13g01280 Aspergillus niger uncharacterized protein XP_059602054.1 320136 R 5061 CDS An13g01290 4986577 join(323573..324129,324184..324213,324315..324645) II 1 NT_166528.1 Remark: alternate name for S. cerevisiae Upc2: YDR213w.; Title: similarity to gene expression regulator At14 from patent WO200257456-A2 - Unclassified organism; uncharacterized protein 324645 4986577 An13g01290 Aspergillus niger uncharacterized protein XP_059602055.1 323573 D 5061 CDS An13g01300 4986578 join(325532..325756,325818..325851,325907..326066,326117..326696,326767..326927,326980..327113,327165..327613) II 1 NT_166528.1 Catalytic activity: (5-L-glutamyl)-peptide + an amino acid <=> peptide + 5-L-glutamyl-amino acid.; Pathway: the human GGT1 protein plays a key role in the gamma-glutamyl cycle, a pathway for the synthesis and degradation of glutathione.; Remark: the human GGT1 enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.; Title: strong similarity to gamma-glutamyl transpeptidase GGT1 - Homo sapiens; See PMID 2904146; See PMID 1678521; uncharacterized protein 327613 4986578 An13g01300 Aspergillus niger uncharacterized protein XP_001396269.3 325532 D 5061 CDS An13g01310 4986579 join(328698..330298,330355..331510) II 1 NT_166528.1 Remark: the human MDB4 protein is identical to the MED1 protein described in patent WO9904626-A1. This patent describes MED1 as a human methyl-CpG binding with an endonuclease activity.; Title: similarity to methyl-CpG binding protein MBD4 - Homo sapiens; nucleus; See PMID 9774669; uncharacterized protein 331510 4986579 An13g01310 Aspergillus niger uncharacterized protein XP_001396270.3 328698 D 5061 CDS An13g01320 4986580 332766..335345 II 1 NT_166528.1 Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: weak similarity to pre-mRNA splicing factor SRp75 - Homo sapiens; uncharacterized protein 335345 4986580 An13g01320 Aspergillus niger uncharacterized protein XP_001396271.1 332766 D 5061 CDS An13g01330 84592802 complement(join(338237..338654,338866..338994,339151..339231,339585..339646)) II 1 NT_166528.1 Title: weak similarity to hypothetical protein CG7709 - Drosophila melanogaster; uncharacterized protein 339646 84592802 An13g01330 Aspergillus niger uncharacterized protein XP_059602056.1 338237 R 5061 CDS An13g01340 4986582 join(343108..343698,343754..344503) II 1 NT_166528.1 Function: the Rhodopsin from Alligator mississippiensis is a visual pigment. It is the light-absorbing molecules that mediate vision. It consists of an apoprotein, opsin and the covalently linked to cis-retinal.; Remark: Alligator mississippiensis=American alligator.; Title: similarity to Rhodopsin - Alligator mississippiensis; plasma membrane; See PMID 8654500; uncharacterized protein 344503 4986582 An13g01340 Aspergillus niger uncharacterized protein XP_001396273.1 343108 D 5061 CDS An13g01350 4986583 join(346340..346396,346473..347000,347052..347924) II 1 NT_166528.1 Function: TRI11 (F. s.) catalyzes the hydroxylation at C-15 of isotrichodermin.; Pathway: the TRI11 enzyme from F. sporotrichioides is involved trichothecene biosynthesis. Trichothecenes are sesquiterpenoid toxins that act by inhibiting protein biosynthesis.; Similarity: TRI11 (F. s.) belongs to the cytochrome p450 family.; Title: strong similarity to cytochrome P450 monooxygenase TRI11 - Fusarium sporotrichioides; See PMID 9435078; uncharacterized protein 347924 4986583 An13g01350 Aspergillus niger uncharacterized protein XP_001396274.1 346340 D 5061 CDS An13g01360 84592803 join(348116..348397,348594..348746) II 1 NT_166528.1 hypothetical protein 348746 84592803 An13g01360 Aspergillus niger hypothetical protein XP_059602057.1 348116 D 5061 CDS An13g01370 4986585 join(349305..349389,349469..349655,349707..350241,350290..350328,350377..350427,350473..350729,350776..351314,351362..351405) II 1 NT_166528.1 hypothetical protein 351405 4986585 An13g01370 Aspergillus niger hypothetical protein XP_001396276.1 349305 D 5061 CDS An13g01380 84592804 join(354269..354409,354483..354607,354746..354881) II 1 NT_166528.1 hypothetical protein 354881 84592804 An13g01380 Aspergillus niger hypothetical protein XP_059602058.1 354269 D 5061 CDS An13g01390 84592805 join(356127..356239,356418..356778) II 1 NT_166528.1 hypothetical protein 356778 84592805 An13g01390 Aspergillus niger hypothetical protein XP_059602059.1 356127 D 5061 CDS An13g01400 84592806 join(358608..358655,358887..359177) II 1 NT_166528.1 Title: weak similarity to protein SEQ ID NO:5202 from patent EP786519-A2 - Staphylococcus aureus; uncharacterized protein 359177 84592806 An13g01400 Aspergillus niger uncharacterized protein XP_059602060.1 358608 D 5061 CDS An13g01410 84592807 join(359746..359916,360040..360209,360408..360534,360634..360712,360789..360880,360928..361005,361099..361144,361234..361378,361425..361616,362303..362493,362828..362913) II 1 NT_166528.1 hypothetical protein 362913 84592807 An13g01410 Aspergillus niger hypothetical protein XP_059602061.1 359746 D 5061 CDS An13g01420 4986590 complement(join(365542..365559,365744..366140,366197..366471,366527..367177,367227..367457)) II 1 NT_166528.1 Function: the E. nidulans AflR protein is involved in the regulation of the sterigmatocystin biosynthesis.; Similarity: the ORF encoded protein and the E. nidulans AflR protein are transcriptional regulators of the fungal Zn(2)-Cys(6) binuclear cluster type.; Title: similarity to sterigmatocystin synthesis transcription regulator aflR - Aspergillus nidulans; nucleus; See PMID 8662194; See PMID 9680223; uncharacterized protein 367457 4986590 An13g01420 Aspergillus niger uncharacterized protein XP_059602062.1 365542 R 5061 CDS An13g01430 10098174 join(368578..368580,368882..368960,369031..369131) II 1 NT_166528.1 hypothetical protein 369131 10098174 An13g01430 Aspergillus niger hypothetical protein XP_003188891.2 368578 D 5061 CDS An13g01440 4986592 complement(join(369629..369769,369815..370142,370189..370319,370368..370751,370793..370913,371083..371192,371242..371378,371425..371554)) II 1 NT_166528.1 Title: strong similarity to multidrug resistance protein fnx1p - Schizosaccharomyces pombe; See PMID 9710608; uncharacterized protein 371554 4986592 An13g01440 Aspergillus niger uncharacterized protein XP_059602063.1 369629 R 5061 CDS An13g01450 4986593 join(372638..373258,373313..374011) II 1 NT_166528.1 Function: the Bacteroides fragilis TetX protein has been shown to act by chemically modifying tetracycline in a reaction that appears to require oxygen and NADPH.; Title: strong similarity to tetracycline resistance causing oxidoreductase tetX - Bacteroides fragilis; See PMID 1846135; uncharacterized protein 374011 4986593 An13g01450 Aspergillus niger uncharacterized protein XP_001396284.3 372638 D 5061 CDS An13g01460 4986594 374326..374718 II 1 NT_166528.1 Remark: the similarity of the ORF encoded protein to the mucin FIM-C. 1 from X. laevis is only based on repetitive structures.; Title: weak similarity to mucin FIM-C.1 - Xenopus laevis; uncharacterized protein 374718 4986594 An13g01460 Aspergillus niger uncharacterized protein XP_001396285.1 374326 D 5061 CDS An13g01470 4986595 complement(join(375111..375328,375404..375533)) II 1 NT_166528.1 Title: weak similarity to laminin gamma 3 chain precursor LAMC3 - Homo sapiens; uncharacterized protein 375533 4986595 An13g01470 Aspergillus niger uncharacterized protein XP_001396286.1 375111 R 5061 CDS An13g01480 4986596 377432..378601 II 1 NT_166528.1 Remark: the patent does not provide any further information on the function of the protein.; Similarity: the patent match is against the translated DNA sequence of patent FR2785293-A/43 (AC# AX024100).; Similarity: the predicted A. niger protein shows similarity to several procaryotic hypothetical proteins.; Title: strong similarity to sequence 43 from patent FR2785293-A - Neisseria meningitidis; uncharacterized protein 378601 4986596 An13g01480 Aspergillus niger uncharacterized protein XP_001396287.3 377432 D 5061 CDS An13g01490 4986597 join(379393..379693,379750..380196,380315..383073) II 1 NT_166528.1 Similarity: similarity of the predicted A. niger protein is due to low complexity sequences.; Title: weak similarity to hypothetical membrane protein YJR151c - Saccharomyces cerevisiae; uncharacterized protein 383073 4986597 An13g01490 Aspergillus niger uncharacterized protein XP_059602064.1 379393 D 5061 CDS An13g01500 84592808 complement(join(383355..383517,383586..383662,383753..383827)) II 1 NT_166528.1 Title: weak similarity to hypothetical protein encoded by An15g02450 - Aspergillus niger; uncharacterized protein 383827 84592808 An13g01500 Aspergillus niger uncharacterized protein XP_059602065.1 383355 R 5061 CDS An13g01510 84592809 complement(join(386759..386861,387032..387105,387197..387271)) II 1 NT_166528.1 Title: similarity to EST an_2981 - Aspergillus niger; uncharacterized protein 387271 84592809 An13g01510 Aspergillus niger uncharacterized protein XP_059602066.1 386759 R 5061 CDS An13g01520 4986600 complement(join(388064..388131,388328..388925)) II 1 NT_166528.1 hypothetical protein 388925 4986600 An13g01520 Aspergillus niger hypothetical protein XP_001396291.3 388064 R 5061 CDS An13g01530 4986601 join(390719..390740,390819..391105) II 1 NT_166528.1 Title: weak similarity to hypothetical protein ycnE - Bacillus subtilis; uncharacterized protein 391105 4986601 An13g01530 Aspergillus niger uncharacterized protein XP_001396292.1 390719 D 5061 CDS An13g01540 4986602 complement(391554..392261) II 1 NT_166528.1 Title: weak similarity to hypothetical protein encoded by An13g01550 - Aspergillus niger; uncharacterized protein 392261 4986602 An13g01540 Aspergillus niger uncharacterized protein XP_001396293.1 391554 R 5061 CDS An13g01550 84592810 complement(join(393690..394101,394245..394333)) II 1 NT_166528.1 Title: weak similarity to hypothetical protein encoded by An13g01540 - Aspergillus niger; uncharacterized protein 394333 84592810 An13g01550 Aspergillus niger uncharacterized protein XP_059602067.1 393690 R 5061 CDS An13g01560 4986604 join(395768..395827,395910..396080,396130..397794) II 1 NT_166528.1 Catalytic activity: receptor tyrosine kinase CCK-2 of patent US5677144-A H. sapiens catalyses the reaction ATP + a protein tyrosine = ADP + protein tyrosine phosphate.; Remark: the protein sequence of human receptor tyrosine kinase CCK-2 of patent US5677144-A (AC# AAW34671) is shorter. the same protein sequence is also covered by patent WO9834954-A2 (AC# AAW77114) and an even shorter protein sequence is covered by patent DE4239817-A (AC# AAR54089). thus, it is not clear whether the full length protein has been cloned yet.; Similarity: the predicted A. niger protein shows local similarity to protein kinases, specifically the amino acids between positions 510 and 600.; Title: similarity to receptor tyrosine kinase CCK-2 from patent US5677144-A - Homo sapiens; deleted EC_number 2.7.1.112; uncharacterized protein 397794 4986604 An13g01560 Aspergillus niger uncharacterized protein XP_001396295.3 395768 D 5061 CDS An13g01570 84592811 complement(join(398495..398592,398650..398699,398761..398891)) II 1 NT_166528.1 hypothetical protein 398891 84592811 An13g01570 Aspergillus niger hypothetical protein XP_059602068.1 398495 R 5061 CDS An13g01580 4986606 join(400032..400431,400484..400946,401008..401719) II 1 NT_166528.1 Remark: disruption of the acr-2 gene in N. crassa lead to progenies that were hypersensitive to acriflavine.; Similarity: N. crassa acr-2 is a Gal4 type transcription factor with a fungal Zn(2)Cys(6) DNA-binding domain.; Similarity: the predicted A. niger protein shows similarity to several Zn(2)Cys(6) DNA-binding domain containing proteins.; Title: strong similarity to transcription factor involved in acriflavine resistance acr-2 - Neurospora crassa; See PMID 8679704; uncharacterized protein 401719 4986606 An13g01580 Aspergillus niger uncharacterized protein XP_001396297.1 400032 D 5061 CDS An13g01590 4986607 join(402712..402931,402990..403504) II 1 NT_166528.1 Catalytic activity: cyanamide hydratase of M. verrucaria catalysys the reaction urea = cyanamide + H2O.; Regulation: the enzyme was detectable only when the fungus was grown on cyanamide as the sole nitrogen source.; Remark: cyanamide hydratase containes zinc and consists of six identical subunits with Mr = 27,700.; Remark: cyanamide hydratase of M. verrucaria is covered by the patent WO9848023-A1 (AC# AAW80804).; Similarity: the predicted A. niger protein is strongly similar to cyanamide hydratase of M. verrucaria and the hypothetical protein YFL061w of S. cerevisiae.; Title: strong similarity to cyanamide hydratase -Myrothecium verrucaria; See PMID 2034671; uncharacterized protein 403504 4986607 An13g01590 Aspergillus niger uncharacterized protein XP_001396298.1 402712 D 5061 CDS An13g01600 4986608 complement(join(403684..403722,403773..404549,404600..404842)) II 1 NT_166528.1 Title: strong similarity to hypothetical protein encoded by An08g01970 - Aspergillus niger; uncharacterized protein 404842 4986608 An13g01600 Aspergillus niger uncharacterized protein XP_001396299.1 403684 R 5061 CDS An13g01610 4986609 join(405128..405145,405212..405732,405831..406258,406313..406661,406780..406908,406958..407411) II 1 NT_166528.1 Title: similarity to hypothetical transcription regulator SPBC530.05 - Schizosaccharomyces pombe; uncharacterized protein 407411 4986609 An13g01610 Aspergillus niger uncharacterized protein XP_059602069.1 405128 D 5061 CDS An13g01620 4986610 complement(join(407674..408176,408238..409084)) II 1 NT_166528.1 Title: similarity to hypothetical protein encoded by An11g07000 - Aspergillus niger; uncharacterized protein 409084 4986610 An13g01620 Aspergillus niger uncharacterized protein XP_001396301.1 407674 R 5061 CDS An13g01630 84592812 complement(join(409945..410080,410170..410218,410424..410720,410810..410946,411063..411145)) II 1 NT_166528.1 hypothetical protein 411145 84592812 An13g01630 Aspergillus niger hypothetical protein XP_059602070.1 409945 R 5061 CDS An13g01640 4986612 join(411531..411685,411824..412475) II 1 NT_166528.1 Function: the detergent-solubilized complex of terminal quinol oxidase oxidizes caldariella quinol at high rates and is completely inhibited by cyanide and by quinolone analogs, potent inhibitors of quinol oxidases.; Remark: multiple alignments and phylogenetic analysis of the heme-bearing subunit I (DoxB) locate this oxidase at the bottom of the phylogenetic tree, in the branch of heme-copper oxidases recently suggested to be incapable of superstoichiometric proton pumping. this finding is corroborated by lack of the essential amino acid residues delineating the putative H+-pumping channel. it is therefore concluded that A. ambivalens copes with its strongly acidic environment simply by an extreme turnover of its terminal oxidase, generating a proton gradient only by chemical charge separation.; Similarity: the predicted A. niger protein shows homology to subunit I of terminal quinol oxidase of A. ambivalens which belongs to the superfamily of respiratory heme-copper oxidases.; Title: weak similarity to subunit I of terminal quinol oxidase doxB - Acidianus ambivalens; plasma membrane; See PMID 9023221; uncharacterized protein 412475 4986612 An13g01640 Aspergillus niger uncharacterized protein XP_059602071.1 411531 D 5061 CDS An13g01650 84592813 complement(join(413074..413450,413673..413691)) II 1 NT_166528.1 Remark: 'frezzled-like protein' seems to be the misspelled 'frizzled-like protein'.; Remark: this is the amino acid sequence of the full length human frezzled-like protein (HFLP), used in the method of the invention. it is a member of the frizzled protein family. it is used in the detection and treatment of differentiation-related disorders. in conditions where HFLP is under-expressed, its agonist is involved in the treatment. antagonist and antibodies of HFLP are used in the treatment of disorder where HFLP is over-expressed, e. g. the regulation of haematopoiesis, and wound healing. HFLP products are used to develop products for treating e. g. cancers, inflammatory and autoimmune diseases,infectious diseases and allergic reactions.; Similarity: the predicted A. niger protein shows homology to the protein sequence of patent WO9909152-A1 (AC# AAY03232).; Title: weak similarity to frizzled-like protein from patent WO9909152-A1 - Homo sapiens; uncharacterized protein 413691 84592813 An13g01650 Aspergillus niger uncharacterized protein XP_059602072.1 413074 R 5061 CDS An13g01660 4986614 414791..415270 II 1 NT_166528.1 Title: strong similarity to EST an_2552 -Aspergillus niger; uncharacterized protein 415270 4986614 An13g01660 Aspergillus niger uncharacterized protein XP_001396305.1 414791 D 5061 CDS An13g01680 4986616 complement(416464..418911) II 1 NT_166528.1 Catalytic activity: D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase (xfp) of. B. lactis catalyses the following reactions: D-fructose 6-phosphate + orthophosphate = acetyl phosphate + D-erythrose 4-phosphate + H2O or D-xylulose 5-phosphate + orthophosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O.; Cofactor: D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase requires thiamine diphosphate as a cofactor.; Pathway: D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase (xfp) of B. lactis is involved in the pentose phosphate cycle, pentose and glucuronate interconversions and aminosugars metabolism.; Similarity: the predicted A. niger protein shows strong similarity to D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase (xfp) of. B. lactis and to hypothetical proteins of several microorganisms.; Title: strong similarity to D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase xfp -Bifidobacterium lactis; See PMID 11292814; uncharacterized protein 418911 4986616 An13g01680 Aspergillus niger uncharacterized protein XP_001396306.1 416464 R 5061 CDS An13g01690 4986617 complement(join(419622..419766,419811..419918,419958..420169,420228..420761)) II 1 NT_166528.1 Remark: the patented protein is involved in abscission or dehiscence. expression of the protein in a transgenic plant can be used to manipulate plant abscission and reduce/prevent pod dehiscence, especially to regulate abscission of pollen from anthers, to generate male sterile plants and for hybrid seed production.; Remark: the protein sequence of the rape hypothetical protein (SAC25) is covered by the patent WO9423043-A (AC# AAR60800).; Similarity: the predicted A. niger protein shows similarity to putative oxidoreductases.; Title: strong similarity to abscission/dehiscence protein from patent WO9423043-A - Brassica napus; uncharacterized protein 420761 4986617 An13g01690 Aspergillus niger uncharacterized protein XP_059602073.1 419622 R 5061 CDS An13g01700 4986618 join(421138..421354,421410..421724,421788..422074,422127..422248,422303..422954,423117..423151,423263..423339,423461..423481,423514..423534,423583..423599) II 1 NT_166528.1 Title: weak similarity to hypothetical protein encoded by An08g05310 - Aspergillus niger; uncharacterized protein 423599 4986618 An13g01700 Aspergillus niger uncharacterized protein XP_059602074.1 421138 D 5061 CDS An13g01710 84592814 424059..424619 II 1 NT_166528.1 hypothetical protein 424619 84592814 An13g01710 Aspergillus niger hypothetical protein XP_059602075.1 424059 D 5061 CDS An13g01720 84592815 join(425793..425981,426072..426380) II 1 NT_166528.1 hypothetical protein 426380 84592815 An13g01720 Aspergillus niger hypothetical protein XP_059602076.1 425793 D 5061 CDS An13g01730 4986621 complement(join(427299..428057,428107..428277)) II 1 NT_166528.1 Remark: the nucleotide sequence partially overlaps with the 3'- non coding sequence of A. ficuum acid phosphatase (aphA).; Title: similarity to hypothetical protein encoded by An09g06230 - Aspergillus niger; uncharacterized protein 428277 4986621 An13g01730 Aspergillus niger uncharacterized protein XP_001396311.1 427299 R 5061 CDS An13g01740 4986622 complement(join(428650..429516,429578..430015)) II 1 NT_166528.1 Remark: the nucleotide sequence overlaps with the 3'- non coding sequence of A. ficuum acid phosphatase (aphA).; Title: similarity to hypothetical protein encoded by An09g06230 - Aspergillus niger; uncharacterized protein 430015 4986622 An13g01740 Aspergillus niger uncharacterized protein XP_001396312.1 428650 R 5061 CDS An13g01750 4986623 complement(join(430750..431101,431155..431595,431645..432340,432389..432744)) II 1 NT_166528.1 Catalytic activity: the acid phosphatase aphA of A. ficuum catalyses the reaction orthophosphoric monoester + H(2)O = alcohol + orthophosphate.; Gene-ID: aphA;pacA; Regulation: the level of expression of the gene in A. niger is affected by phosphate concentration and pH of the growth medium.; Similarity: the predicted A. niger protein is highly similar (identical amino acids exceed 95%) to the acid phosphatase aphA of A. ficuum and partial sequences of acid phosphatase of A. niger. the protein sequence of TREMBL:AN18554_1 of A. niger lacks the N-terminus, which can be found in the protein sequence of PIR:JT0386 of A. niger. however, this latter sequence shows some discrepancy with downstream segments of the aphA of A. ficuum or A. niger, which might be due to alternative splicing.; See PMID 3224828; acid phosphatase aphA-Aspergillus niger 432744 aphA 4986623 aphA Aspergillus niger acid phosphatase aphA-Aspergillus niger XP_001396313.1 430750 R 5061 CDS An13g01760 4986624 complement(join(434163..434338,434437..434449,434623..435198,435255..435437,435492..435821,435874..435971,436029..436183,436232..436438,436494..436768,436838..437136,437199..437265)) II 1 NT_166528.1 Function: OPT1 of C. albicans was cloned from a C. albicans genomic library through heterologous expression in the S. cerevisiae di-/tripeptide transport mutant PB1X-9B. OPT1 restored oligopeptide transport in the mutant cells,as indicated by growth on the tetrapeptide Lys-Leu-Leu-Gly,sensitivity to toxic tetra- and pentapeptides, and an increase in the initial uptake rate of the radiolabelled tetrapeptide Lys-Leu-Gly-[3H]Leu.; Remark: C. albicans oligopeptide transporter OPT1 is probably localized in the plasma membrane.; Remark: the hypothetical protein SPAC29B12. 10c of Schizosaccharomyces pombe is covered by patent WO200052162-A2 (AC# AAY96165). the present sequence is that of an oligopeptide transporter (OPT) family member from S. pombe, designated emb CAB16254. 1. members of the OPT family have been identified in yeasts and plants. the invention relates to a novel OPT of S. cerevisiae,designated OPT1 (see AAY96149). OPT1 is the first example of a genetically defined eukaryotic transport protein which can transport enkephalins across the cell membrane. vectors allowing expression of the OPT1 gene, transgenic plants, and treatment of OPT1p with toxic enkephalins as an antifungal method are claimed. also claimed is a method for obtaining mammalian enkephalin transporters by functional complementation of OPT1 deficient yeast.; Title: strong similarity to oligopeptide transporter OPT1 - Candida albicans; plasma membrane; See PMID 9043116; uncharacterized protein 437265 4986624 An13g01760 Aspergillus niger uncharacterized protein XP_059602077.1 434163 R 5061 CDS An13g01770 84592816 join(437837..437935,438039..438123,438245..438380,438464..438647) II 1 NT_166528.1 Title: weak similarity to hypothetical translated cDNA FLJ13744 - Homo sapiens; uncharacterized protein 438647 84592816 An13g01770 Aspergillus niger uncharacterized protein XP_059602078.1 437837 D 5061 CDS An13g01780 4986626 439471..439986 II 1 NT_166528.1 Remark: new sequence determined DNA fragments (SDFs) from different plant species may be useful for protein identification and for aiding in the elucidation of signal transduction and metabolic pathways. its coding sequence has a use in the control of gene expression as a promoter,coding sequence, 3'UTR or termination sequence, for controlling the behaviour of a gene within the chromosome,as a tool for use in genetic mapping, including a use in hybridisation assays, for recognition or isolation of similar DNA fragments, or for the identification of a particular organism.; Remark: the patent match is against the protein fragment SEQ ID NO: 52620 of patent EP1033405-A2 (AC# AAG42215).; Title: weak similarity to protein fragment SEQ ID NO:52620 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 439986 4986626 An13g01780 Aspergillus niger uncharacterized protein XP_001396316.1 439471 D 5061 CDS An13g01790 4986627 complement(join(440075..440423,440470..440615,440682..441698,441741..441878)) II 1 NT_166528.1 Remark: new sequence determined DNA fragments (SDFs) from different plant species may be useful for protein identification and for aiding in the elucidation of signal transduction and metabolic pathways. its coding sequence has a use in the control of gene expression as a promoter,coding sequence, 3'UTR or termination sequence, for controlling the behaviour of a gene within the chromosome,as a tool for use in genetic mapping, including a use in hybridisation assays, for recognition or isolation of similar DNA fragments, or for the identification of a particular organism.; Remark: the patent does not provide further information about the function of the protein.; Remark: the patent match is against the protein fragment SEQ ID NO: 75858 of patent EP1033405-A2 (AC# AAG58725).; Title: similarity to protein fragment SEQ ID NO:75858 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 441878 4986627 An13g01790 Aspergillus niger uncharacterized protein XP_059602079.1 440075 R 5061 CDS An13g01800 4986628 complement(442371..443399) II 1 NT_166528.1 Title: strong similarity to hypothetical protein encoded by An15g07140 - Aspergillus niger; uncharacterized protein 443399 4986628 An13g01800 Aspergillus niger uncharacterized protein XP_001396318.1 442371 R 5061 CDS An13g01810 4986629 complement(join(444908..445753,445808..445974,446022..446682,446742..446870)) II 1 NT_166528.1 Catalytic activity: 4-hydroxyacetophenone monooxygenase (HAPMO) of P. fluorescens catalyses the reaction 4-hydroxyphenylacetate + NAD(P)H + O(2) = 3,4-dihydroxyphenylacetate + NAD(P)(+) + H(2)O.; Remark: HAPMO of P. fluorescens is a homodimer of approximately 140 kDa with each subunit containing a noncovalently bound FAD molecule.; Similarity: the predicted A. niger protein and 4-hydroxyacetophenone monooxygenase (HAPMO) of P. fluorescens show homology to flavin-containing monooxygenases.; Title: strong similarity to 4-hydroxyacetophenone monooxygenase hapE - Pseudomonas fluorescens; See PMID 11322873; uncharacterized protein 446870 4986629 An13g01810 Aspergillus niger uncharacterized protein XP_059602080.1 444908 R 5061 CDS An13g01820 84592817 join(446999..447022,447131..447196,447231..447372,447409..447476,447557..447678,447784..447865) II 1 NT_166528.1 hypothetical protein 447865 84592817 An13g01820 Aspergillus niger hypothetical protein XP_059602081.1 446999 D 5061 CDS An13g01830 84592818 complement(join(448116..448170,448275..448577,448651..448978,449101..449147,449222..449336,449425..449691,449730..449827,449895..450053,450139..450298,450369..450521,450686..450824,450907..450954,451055..451060,451175..451264,451351..451560)) II 1 NT_166528.1 Remark: Sak serine-threonine kinase may be useful for identifying modulators potentially useful in treatment or prevention of proliferative disease.; Remark: the patent WO200039322-A1 (AC# AAR92214) covers SAK-b serine-threonine kinase of M. musculus.; Title: weak similarity to SAK-b serine-threonine kinase from patent CA2150789-A - Mus musculus; uncharacterized protein 451560 84592818 An13g01830 Aspergillus niger uncharacterized protein XP_059602082.1 448116 R 5061 CDS An13g01840 4986632 join(451850..453123,453177..453300) II 1 NT_166528.1 Catalytic activity: dimethylallyltryptophan synthase of C. purpurea catalyses the reaction dimethylallyl diphosphate + L-tryptophan = diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan.; Function: dimethylallyltryptophan synthase of C. purpurea (also known as tryptophan dimethylallyltransferase) is a prenyltransferase, which catalyses the first step in ergot alkaloid biosynthesis.; Remark: ergot alkaloids (EAs), products of Claviceps spp., are widely used in various fields of clinical medicine (neurology, psychiatry, endocrinology).; Remark: the A. oryzae dimethylallyl-cycloacetoacetyl-L-tryptophan synthase (DCAT-S) is involved in the synthesis of beta-CPA, from cyclo-acetoacetyl-L-tryptophan and dimethylallylpyrophosphate, by its homology to a dimethylallyltryptophan synthase (DMAT-S) from Claviceps purpurea. Aspergillus host cells having a modification in the DCAT-S gene, leading to reduced or eliminated toxin production, are useful for expression of heterologous polypeptides of interest. other toxins which may be reduced or eliminated comprise kojic acid, 3-nitropropionic acid,emodin, etc. the DCAT-S gene can be used to identify and disrupt similar genes in other filamentous fungal host strains such as Trichoderma, Penicillium and Fusarium.; Remark: the patent match is against dimethylallyl-cycloacetoacetyl-L-tryptophan synthase (DCAT-S) of A. oryzae, which is covered by patent WO200039322-A1 (AC# AAY96961).; Title: strong similarity to dimethylallyltryptophan synthase dmaW - Claviceps purpurea; See PMID 7488077; See PMID 11036684; See PMID 1605639; uncharacterized protein 453300 4986632 An13g01840 Aspergillus niger uncharacterized protein XP_001396322.1 451850 D 5061 CDS An13g01850 84592819 complement(join(453781..453834,453929..453981,454064..454255,454348..454515,454608..454668,454765..454800)) II 1 NT_166528.1 hypothetical protein 454800 84592819 An13g01850 Aspergillus niger hypothetical protein XP_059602083.1 453781 R 5061 CDS An13g01860 4986634 complement(join(455845..455885,455929..455972,456236..457408,457479..457549,457620..457787)) II 1 NT_166528.1 Induction: transcription of the gabA gene of A. nidulans is activated by the transcription factor IntA.; Remark: in A. niger GABA is used as a nitrogen source.; Remark: in agreement with the wealth of genetic data available, transcript level analyses demonstrate that gabA (A. nidulans) is subject to carbon catabolite and nitrogen metabolite repression, omega-amino acid induction and regulation in response to ambient pH (being acid-expressed).; Repression: transcription of the gabA gene of A. nidulans is repressed by the zinc finger transcription factor PacC.; Similarity: the predicted A. niger protein shows also similarity to several putative fungal aminoacid permeases.; Title: strong similarity to GABA permease gabA -Aspergillus nidulans; See PMID 10320578; uncharacterized protein 457787 4986634 An13g01860 Aspergillus niger uncharacterized protein XP_001396324.3 455845 R 5061 CDS An13g01870 4986635 join(458510..458548,458589..458666,458724..458932,459086..459160,459314..459527,459624..459689,459831..460097,460214..460639) II 1 NT_166528.1 Title: similarity to hypothetical protein encoded by An04g06980 - Aspergillus niger; uncharacterized protein 460639 4986635 An13g01870 Aspergillus niger uncharacterized protein XP_059602084.1 458510 D 5061 CDS An13g01880 4986636 join(461919..462230,462290..462637,462686..463714) II 1 NT_166528.1 Catalytic activity: Triacylglycerol + H2O = Diacylglycerol + a Carboxylate; Diacylglycerol + H2O = Monoacylglycerol + a Carboxylate.; Pathway: Glycerolipid metabolism.; Remark: R. toruloides cephalosporin esterase is covered by patent WO9812345-A1 (AC# AAW54159).; Remark: the cephalosporin esterase from Rhodosporidium toruloides has EC 3. 1. 1. 41.; Title: strong similarity to cephalosporin esterase -Rhodosporidium toruloides; See PMID 9406399; See PMID 10878123; uncharacterized protein 463714 4986636 An13g01880 Aspergillus niger uncharacterized protein XP_001396326.3 461919 D 5061 CDS An13g01890 4986637 join(464166..464247,464341..464457,464591..464779,464879..465285) II 1 NT_166528.1 Similarity: the predicted A. niger protein shows similarity to conserved hypothetical proteins from different microbial organisms.; Title: similarity to hypothetical protein Rv1147 -Mycobacterium tuberculosis; uncharacterized protein 465285 4986637 An13g01890 Aspergillus niger uncharacterized protein XP_059602085.1 464166 D 5061 CDS An13g01900 84592820 join(466374..467449,467508..467873,468055..468080,468155..468222) II 1 NT_166528.1 Title: weak similarity to hypothetical Kruppel-related gene 3 HKR3 - Homo sapiens; uncharacterized protein 468222 84592820 An13g01900 Aspergillus niger uncharacterized protein XP_059602086.1 466374 D 5061 CDS An13g01910 84592821 join(470063..470071,470311..471819) II 1 NT_166528.1 Remark: similarity is mainly due to serines and prolines in the protein.; Title: weak similarity to hypothetical pollen extensin-like protein Pex2 - Zea mays; uncharacterized protein 471819 84592821 An13g01910 Aspergillus niger uncharacterized protein XP_059602087.1 470063 D 5061 CDS An13g01920 4986640 join(472113..472394,472444..473388,473436..473636) II 1 NT_166528.1 Catalytic activity: acetyl-CoA C-acetyltransferase catalyzes the reversible reaction: acetoacetyl-CoA + CoA = 2 acetyl-CoA.; Function: acetyl-CoA C-acetyltransferase plays a major role in ketone body metabolism.; Remark: acetyl-CoA C-acetyltransferase is a tetramer of identical chains.; Title: strong similarity to precursor of acetyl-CoA C-acetyltransferase - Rattus norvegicus; localisation:mitochondrion; See PMID 2478525; uncharacterized protein 473636 4986640 An13g01920 Aspergillus niger uncharacterized protein XP_001396330.3 472113 D 5061 CDS An13g01930 4986641 complement(join(473733..475271,475344..475370)) II 1 NT_166528.1 Similarity: SSADH contains significant homology to bacterial NADP(+)-succinic semialdehyde dehydrogenase (EC 1. 2. 1. 16) and conserved regions of general aldehyde dehydrogenases (EC 1. 2. 1. 3), suggesting it is a member of the aldehyde dehydrogenase superfamily of proteins.; Title: strong similarity to succinate-semialdehyde dehydrogenase SSADH - Rattus norvegicus; See PMID 7814412; uncharacterized protein 475370 4986641 An13g01930 Aspergillus niger uncharacterized protein XP_059602088.1 473733 R 5061 CDS An13g01940 4986642 complement(475636..477276) II 1 NT_166528.1 Catalytic activity: 3-Oxoadipate enol-lactone + H2O = 3-Oxoadipate.; Title: similarity to 3-oxoadipate enol-lactone hydrolase catD - Pseudomonas sp.; See PMID 11741863; uncharacterized protein 477276 4986642 An13g01940 Aspergillus niger uncharacterized protein XP_001396332.1 475636 R 5061 CDS An13g01950 84592822 join(477336..477373,477473..477559,477646..477793,477895..477978,478060..478101,478263..478328) II 1 NT_166528.1 hypothetical protein 478328 84592822 An13g01950 Aspergillus niger hypothetical protein XP_059602089.1 477336 D 5061 CDS An13g01960 4986644 complement(join(478390..478469,478514..478941,479028..479166,479284..479469,479577..480294,480348..480554)) II 1 NT_166528.1 Function: alkJ is membrane-bound and converts aliphatic medium-chain-length alcohols into aldehydes.; Remark: Pseudomonas putida was formerly annotated as Pseudomonas oleovorans.; Remark: alkJ is encoded on the plasmid OCT in the alkBFGHJKL operon.; Remark: the alkBFGHJKL and alkST operons encode enzymes that allow Pseudomonas putida (oleovorans) to metabolize alkanes.; Title: strong similarity to alcohol dehydrogenase alkJ - Pseudomonas putida; plasma membrane; See PMID 1453953; uncharacterized protein 480554 4986644 An13g01960 Aspergillus niger uncharacterized protein XP_059602090.1 478390 R 5061 CDS An13g01970 84592823 join(480994..481021,481506..481628,482115..482184,482266..482359,482588..482804,482865..483017,483147..483226,483288..483392) II 1 NT_166528.1 hypothetical protein 483392 84592823 An13g01970 Aspergillus niger hypothetical protein XP_059602091.1 480994 D 5061 CDS An13g01980 4986646 join(484708..484717,484919..485045,485148..485576,485629..486634) II 1 NT_166528.1 Title: similarity to hypothetical membrane protein YDL237w - Saccharomyces cerevisiae; uncharacterized protein 486634 4986646 An13g01980 Aspergillus niger uncharacterized protein XP_001396336.3 484708 D 5061 CDS An13g01990 84592824 join(487532..487878,488218..488522,488628..488761) II 1 NT_166528.1 Title: similarity to hypothetical protein encoded by An08g03120 - Aspergillus niger; uncharacterized protein 488761 84592824 An13g01990 Aspergillus niger uncharacterized protein XP_059602092.1 487532 D 5061 CDS An13g02000 4986648 complement(join(489805..490501,490561..490811)) II 1 NT_166528.1 Catalytic activity: catA catalyzes the oxygenative ring cleavage of catechol to form cis,cis-muconic acid.; Title: strong similarity to catechol 1,2-dioxygenase catA - Pseudomonas putida; See PMID 7646060; uncharacterized protein 490811 4986648 An13g02000 Aspergillus niger uncharacterized protein XP_001396338.1 489805 R 5061 CDS An13g02010 84592825 complement(join(492351..492406,492452..492485)) II 1 NT_166528.1 Remark: questionable due to small size and lack of homologies.; Title: questionable ORF; uncharacterized protein 492485 84592825 An13g02010 Aspergillus niger uncharacterized protein XP_059602093.1 492351 R 5061 CDS An13g02020 4986650 join(494378..494778,494867..495041,495093..495422) II 1 NT_166528.1 Title: strong similarity to hypothetical protein YCR010c - Saccharomyces cerevisiae; uncharacterized protein 495422 4986650 An13g02020 Aspergillus niger uncharacterized protein XP_001396340.3 494378 D 5061 CDS An13g02030 4986651 complement(join(495865..496065,496141..496382,496466..496940,496997..497208,497260..497349,497408..497651,497706..497873)) II 1 NT_166528.1 Function: GAP1 is the general amino acid permease gene of S. cerevisiae that catalyses active transport of apparently all biological amino acids across the plasma membrane.; Induction: GAP1 activity is regulated according to nitrogen source, the activity being high on urea and low on glutamate; this regulation is due to differential protein sorting from the Golgi complex to either the plasma membrane or the vacuole.; Phenotype: mutations at the GAP1 locus selectively abolish the activity of the general amino acid transport system.; Title: strong similarity to general amino acid permease Gap1 - Saccharomyces cerevisiae; plasma membrane; uncharacterized protein 497873 4986651 An13g02030 Aspergillus niger uncharacterized protein XP_001396341.1 495865 R 5061 CDS An13g02040 84592826 complement(join(498342..498510,498602..498862,498955..499004)) II 1 NT_166528.1 Title: weak similarity to GAL4 DNA binding domain from patent WO9633724-A2 - Homo sapiens; uncharacterized protein 499004 84592826 An13g02040 Aspergillus niger uncharacterized protein XP_059602094.1 498342 R 5061 CDS An13g02050 4986653 join(499210..499383,499431..500183) II 1 NT_166528.1 Title: similarity to MmcH encoded protein sequence from patent WO200053737-A2 - Streptomyces lavendulae; uncharacterized protein 500183 4986653 An13g02050 Aspergillus niger uncharacterized protein XP_001396343.1 499210 D 5061 CDS An13g02060 4986654 join(502849..503107,503184..503725,503781..504120,504192..504616) II 1 NT_166528.1 Function: Tri4 gene of Fusarium sporotrichioides encodes a cytochrome P450 monooxygenase involved in trichothecene biosynthesis.; Phenotype: disruption of Tri4 results in the loss of production of both trichothecenes and apotrichodiol and the accumulation of the unoxygenated pathway intermediate trichodiene.; Remark: trichothecenes are sesquiterpenoid toxins that act by inhibiting protein biosynthesis.; Similarity: the Tri4 gene has been placed in a new cytochrome P450 gene family designated CY P58.; Title: strong similarity to cytochrome P450 monooxygenase TRI4 - Fusarium sporotrichioides; See PMID 7651333; uncharacterized protein 504616 4986654 An13g02060 Aspergillus niger uncharacterized protein XP_001396344.1 502849 D 5061 CDS An13g02070 4986655 complement(join(505913..505955,506031..506324,506392..506639)) II 1 NT_166528.1 Title: similarity to hypothetical protein MUK11 -Arabidopsis thaliana; uncharacterized protein 506639 4986655 An13g02070 Aspergillus niger uncharacterized protein XP_059602095.1 505913 R 5061 CDS An13g02080 4986656 complement(join(506870..508575,508624..508981,509030..509463,509515..509634,509684..510232,510280..511044,511092..511202,511267..511303)) II 1 NT_166528.1 Catalytic activity: 5-oxoprolinase catalyzes a reaction in which the endergonic cleavage of 5-oxo-L-proline to form L-glutamate is coupled to the exergonic hydrolysis of ATP to ADP and inorganic phosphate.; Remark: 5-oxoprolinase is composed of two strongly interacting, apparently identical subunits.; Remark: evolutionary relationships exist among the hydantoinases and rat kidney 5-oxoprolinase which share the common property of hydrolyzing the imide bond of 5-membered rings.; Title: strong similarity to ATP-hydrolyzing 5-oxoprolinase - Rattus norvegicus; See PMID 8943290; uncharacterized protein 511303 4986656 An13g02080 Aspergillus niger uncharacterized protein XP_059602096.1 506870 R 5061 CDS An13g02090 4986657 join(512076..512252,512302..512377,512424..512479,512530..512683,512750..512947,512994..513227,513274..513528,513658..513741,513821..514068) II 1 NT_166528.1 Repression: allantoate uptake by DAL5 is constitutive but is sensitive to nitrogen catabolite repression.; Similarity: DAL5 is a member of the allantoate family of the major facilitator superfamily (MFS).; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 3301804; See PMID 3549700; uncharacterized protein 514068 4986657 An13g02090 Aspergillus niger uncharacterized protein XP_059602097.1 512076 D 5061 CDS An13g02100 4986658 join(514494..514539,514595..514720,514783..515339,515394..515609,515658..515789) II 1 NT_166528.1 Title: weak similarity to transcription factor Cat8 - Kluyveromyces lactis; uncharacterized protein 515789 4986658 An13g02100 Aspergillus niger uncharacterized protein XP_001396348.3 514494 D 5061 CDS An13g02110 4986659 complement(join(516386..517652,517721..518049)) II 1 NT_166528.1 Catalytic activity: an alpha-L-fucoside + H(2)O = an alcohol + L-fucose.; Function: alpha-l-fucosidase FUCA1 is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end n-acetylglucosamine of the carbohydrate moieties of glycoproteins.; Localization: FUCA1 has a lysosomal localization.; Remark: an unusual aspect of rat liver alpha-L-fucosidase FUCA1 protein structure is its high content of tryptophan (6%).; Similarity: FUCA1 belongs to family 29 of glycosyl hydrolases.; Title: strong similarity to tissue alpha-L-fucosidase precursor FUCA1 - Rattus norvegicus; lysosome; See PMID 2482732; uncharacterized protein 518049 4986659 An13g02110 Aspergillus niger uncharacterized protein XP_001396349.3 516386 R 5061 CDS An13g02120 84592827 join(519253..519365,519411..519940,519996..>520250) II 1 NT_166528.1 Remark: C-terminally truncated due to contig border.; Title: similarity to hypothetical protein CAD37048.1 - Neurospora crassa [truncated ORF]; uncharacterized protein 520250 84592827 An13g02120 Aspergillus niger uncharacterized protein XP_059602098.1 519253 D 5061 CDS An13g02130 4986661 complement(join(520487..521478,521531..521849,521901..522068)) II 1 NT_166528.1 Catalytic activity: YPS3 of S. cerevisiae is a protease with endoproteolitic specificity for basic residue cleavage sites.; Localization: as its close homolgues YPS1 and YPS2,YPS3 of S. cerevisiae contain a C-terminal GPI-anchoring signal, and is probably bound to the plasma membrane.; Remark: YPS3 of S. cerevisiae is also called YPS4 or YLR121C.; Similarity: YPS3 of S. cerevisiae belongs to the yapsin group of enzymes, a subfamily of aspartic proteases; other yeast genes, as well as the mammalian pro-opiomelanocortin converting enzyme belong to this group.; Title: strong similarity to aspartic proteinase Yps3 - Saccharomyces cerevisiae; See PMID 10191273; uncharacterized protein 522068 4986661 An13g02130 Aspergillus niger uncharacterized protein XP_001396351.1 520487 R 5061 CDS An13g02140 84592828 complement(join(522704..523064,523121..523483,523533..524305)) II 1 NT_166528.1 Function: mal 23-c of S. cerevisiae is part of the complex locus MAL2, involved in the regulation of maltose utilization; Remark: the fungal Zn N-terminus domain forms a binuclear Zn cluster, in which two Zn atoms are bound by six Cys residues.; Similarity: in the N-terminal part of the predicted ORF there is a very well conserved fungal transcriptional regulatory protein Zn N-terminus domain, a Cys rich motif that is involved in zinc-dependent binding of DNA.; Similarity: the main feature of the predicted ORF is that it shows short regions of strong similarity with several proteins, all corresponding to well defined domains.; Title: similarity to MAL-activator 23-C Mal23-c -Saccharomyces cerevisiae; See PMID 3036644; uncharacterized protein 524305 84592828 An13g02140 Aspergillus niger uncharacterized protein XP_059602099.1 522704 R 5061 CDS An13g02150 4986663 join(524890..525241,525291..525620,525669..525876,525927..526288,526342..526634) II 1 NT_166528.1 Function: FLU1 of C. albicans confers resistance to fluconazole and cycloheximide to a S. cerevisiae strain hypersensitive to multiple drugs.; Function: multidrug transporters are membrane proteins which, by an unknown mechanism, recognize diverse toxic compounds and efflux them from cells.; Similarity: the predicted ORF shows strong similarity to known and hypothetical members of the multidrug efflux transporters belonging to the major facilitator superfamily of transport proteins.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 8987357; See PMID 11065353; uncharacterized protein 526634 4986663 An13g02150 Aspergillus niger uncharacterized protein XP_001396353.1 524890 D 5061 CDS An13g02160 4986664 join(527530..528256,528290..529161) II 1 NT_166528.1 Catalytic activity: a carboxylic ester + H2O = an alcohol + a carboxylate.; Function: PNBA of B. subtilis catalyzes hydrolysis of several beta-lactam antibiotic p-nitrobenzyl (PNB) esters to the corresponding free acid and PNB alcohol, a process that can be important in the manufacturing of clinically important oral drugs.; Function: carboxylesterases show wide specificity.; Function: in humans, carboxylesterases play an important role in the hydrolytic biotransformation of a vast number of structurally diverse drugs.; Similarity: PNBA of B. subtilis has high homology to members of carboxylesterase type B superfamily.; Similarity: the predicted ORF shows strong similarity to bacterial esterase (BEST1), patentnummer WO9902703-A1, which can be useful for the degradation and detoxification of fumonisins, which are toxic and potentially widespread in food and feed.; Title: strong similarity to p-nitrobenzyl esterase pnbA - Bacillus subtilis; See PMID 7828905; See PMID 9597156; uncharacterized protein 529161 4986664 An13g02160 Aspergillus niger uncharacterized protein XP_059602100.1 527530 D 5061 CDS An13g02170 84592829 complement(join(529375..529482,529521..529553,529691..529717)) II 1 NT_166528.1 Similarity: the predicted ORF shows a partial weak similarity to a region of the 1,3-beta-glucanase of L. esculentum (tomato).; hypothetical protein 529717 84592829 An13g02170 Aspergillus niger hypothetical protein XP_059602101.1 529375 R 5061 CDS An13g02180 4986666 complement(join(530446..531409,531455..531576,531623..531675,531720..531952,531997..532382,532434..532928)) II 1 NT_166528.1 Catalytic activity: CFL1 of C. albicans, as well as the S. cerevisiae homologue FRE1, can reduce copper (Cu2+ to Cu+) besides iron.; Catalytic activity: NADH + 2 Fe(3+) = NAD(+) + 2 Fe(2+); Function: CFL1 of C. albicans can functionally rescue the S. cerevisiae fre1 mutants, lacking the ferric reductase activity.; Function: ferric reductase in C. albicans and other yeasts is used to reduce iron extracellularly and then specifically transport the ferrous iron into the cell.; Induction: C. albicans reductase activity is induced in low-iron conditions, and upon exit of stationary growth phase.; Localization: FRE1 of S. cerevisiae, the homologue of CFL1 of C. albicans, is an integral membrane protein.; Repression: C. albicans reductase activity is negatively regulated by copper.; Title: strong similarity to ferric reductase CFL1 -Candida albicans; See PMID 8868423; See PMID 10784045; uncharacterized protein 532928 4986666 An13g02180 Aspergillus niger uncharacterized protein XP_001396356.1 530446 R 5061 CDS An13g02200 84592830 join(536177..536449,536670..536787,536824..536936) II 1 NT_166528.1 hypothetical protein 536936 84592830 An13g02200 Aspergillus niger hypothetical protein XP_059602102.1 536177 D 5061 CDS An13g02210 84592831 complement(join(537437..537603,537774..537861,537953..538123)) II 1 NT_166528.1 Similarity: the predicted ORF has partial weak similarity to the replication protein-binding trans-activator RBT1 of M. musculus.; hypothetical protein 538123 84592831 An13g02210 Aspergillus niger hypothetical protein XP_059602103.1 537437 R 5061 CDS An13g02220 4986670 join(538199..538482,538537..538573,538627..538654,538716..538752,538809..539076) II 1 NT_166528.1 Title: similarity to hypothetical protein encoded by An19g00010 - Aspergillus niger; uncharacterized protein 539076 4986670 An13g02220 Aspergillus niger uncharacterized protein XP_001396360.3 538199 D 5061 CDS An13g02230 84592832 539686..540015 II 1 NT_166528.1 Title: strong similarity to EST AN04C06 -Aspergillus niger; uncharacterized protein 540015 84592832 An13g02230 Aspergillus niger uncharacterized protein XP_059602104.1 539686 D 5061 CDS An13g02240 4986672 complement(join(540239..541372,541426..541509,541673..541911,541961..542108)) II 1 NT_166528.1 Function: HOL1 of S. cerevisiae seems to be involved in the uptake of several cations and of histidinol.; Phenotype: gain-of-function HOL1 mutations in S. cerevisiae confer increased uptake rates of cations (including K+ and Na+) and histidinol; these mutations provoke amino-acid substitutions within the predicted transmembrane domains.; Similarity: HOL1 of S. cerevisiae belongs to the major facilitator family (also known as the multidrug resistance translocase family) of transport proteins.; Title: strong similarity to multidrug resistance protein Hol1 - Saccharomyces cerevisiae; plasma membrane; See PMID 8955402; See PMID 2405251; uncharacterized protein 542108 4986672 An13g02240 Aspergillus niger uncharacterized protein XP_059602105.1 540239 R 5061 CDS An13g02250 4986673 complement(join(542789..542918,542968..543390,543443..543646,543697..543974)) II 1 NT_166528.1 Title: similarity to hypothetical protein SC1C3.21 SC1C3.21 - Streptomyces coelicolor; uncharacterized protein 543974 4986673 An13g02250 Aspergillus niger uncharacterized protein XP_001396363.1 542789 R 5061 CDS An13g02260 4986674 join(544375..546003,546063..546200) II 1 NT_166528.1 Function: glutaryl 7-ACA acylase deacetylates 7 beta-(4-carboxybutanamido)cephalosporanic acid (glutaryl 7-ACA) to 7-amino cephalosporanic acid (7-ACA).; Localization: extracellular excretion of glutaryl 7-ACA acylase was observed in a recombinant strain of B. subtilis.; Title: similarity to glutaryl 7-ACA acylase -Bacillus laterosporus; See PMID 1744041; uncharacterized protein 546200 4986674 An13g02260 Aspergillus niger uncharacterized protein XP_001396364.1 544375 D 5061 CDS An13g02270 4986675 547921..548790 II 1 NT_166528.1 Function: actVII is a dehydrase and forms part of the polyketide synthase for the antibiotic actinorhodin,which consists of discrete monofunctional components.; Title: similarity to dehydrase actVII - Streptomyces coelicolor; See PMID 1527048; uncharacterized protein 548790 4986675 An13g02270 Aspergillus niger uncharacterized protein XP_059602106.1 547921 D 5061 CDS An13g02280 84592833 complement(join(549314..549562,549671..549682)) II 1 NT_166528.1 Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 549682 84592833 An13g02280 Aspergillus niger uncharacterized protein XP_059602107.1 549314 R 5061 CDS An13g02290 4986677 550414..551415 II 1 NT_166528.1 Function: N. crassa qa-4 catalyzes the third step of the quinic acid (qa) catabolic pathway.; Function: in N. crassa five structural and two regulatory genes mediate the initial events in quinate/shikimate metabolism as a carbon source.; Induction: N. crassa qa-4 is induced by quinic acid.; Title: strong similarity to 3-dehydroshikimate dehydratase qa-4 - Neurospora crassa; See PMID 2525625; See PMID 6241580; uncharacterized protein 551415 4986677 An13g02290 Aspergillus niger uncharacterized protein XP_001396367.1 550414 D 5061 CDS An13g02300 4986678 551691..552767 II 1 NT_166528.1 Similarity: the predicted A. niger ORF contains a fungal Gal4 type Zn(2)-Cys(6) DNA-binding motif.; Title: similarity to sterigmatocystin synthesis transcription regulator aflR - Aspergillus nidulans; nucleus; See PMID 8662194; uncharacterized protein 552767 4986678 An13g02300 Aspergillus niger uncharacterized protein XP_059602108.1 551691 D 5061 CDS An13g02310 4986679 complement(join(552924..553532,553608..553805)) II 1 NT_166528.1 Catalytic activity: Ribitol dehydrogenases convert Ribitol + NAD(+) to D-ribulose + NADH.; Function: K. aerogenes rbtD is required for the utilisation of ribitol as a carbon source.; Title: strong similarity to Ribitol dehydrogenase rbtD - Klebsiella aerogenes; See PMID 2933028; uncharacterized protein 553805 4986679 An13g02310 Aspergillus niger uncharacterized protein XP_001396369.1 552924 R 5061 CDS An13g02320 84592834 complement(554369..>554827) II 1 NT_166528.1 Function: A. thaliana mrp2 is a MgATP-energized pump active in the transport of glutathione (GS) and glucuronate conjugates and other bulky amphipathic anions across the vacuolar membrane.; Localization: A. thaliana mrp2 localizes to the vacuolar membrane fraction.; Remark: ORF 5'truncated due to end of contig.; Similarity: A. thaliana mrp2 is an ATP-binding cassette (ABC) transporter of the multidrug resistance-associated protein (MRP) family.; Title: strong similarity to glutathione S-conjugate ABC-transporter MRP2 - Arabidopsis thaliana [truncated ORF]; vacuole; See PMID 9693718; See PMID 11115509; uncharacterized protein 554827 84592834 An13g02320 Aspergillus niger uncharacterized protein XP_059602109.1 554369 R 5061 CDS An13g02330 84592835 complement(<554931..556508) II 1 NT_166528.1 Function: ATP-dependent transport of bile acids is a key determinant of bile flow in mammalian liver and is associated with cholesterol excretion, gallstone formation,and numerous inherited and acquired hepatobiliary diseases.; Remark: C-terminal truncated ORF due to end of contig.; Remark: the systematic name for YBT1 of S. cerevisiae is YLL048c.; Similarity: the ORF shows similarity to various multidrug resistance proteins, which are also active in ATP-dependent substrate transport.; Similarity: the aligment is over the C-terminal part of the predicted ORF, containing putative transmembrane stretches, but not a ATP-binding domain.; Title: similarity to membrane protein Ybt1 -Saccharomyces cerevisiae [truncated ORF]; See PMID 8139928; See PMID 9182565; uncharacterized protein 556508 84592835 An13g02330 Aspergillus niger uncharacterized protein XP_059602110.1 554931 R 5061 CDS An13g02340 4986682 join(557514..557865,557945..558600) II 1 NT_166528.1 Similarity: similarity to human breast tumour-associated protein 77 patent DE19813839-A1.; Similarity: to dehydrogenases with different specificities.; Title: similarity to tumour-associated protein 77 from patent DE19813839-A1 - Homo sapiens; uncharacterized protein 558600 4986682 An13g02340 Aspergillus niger uncharacterized protein XP_001396372.1 557514 D 5061 CDS An13g02350 4986683 join(558778..558800,558982..559162,559304..559339,559429..559446,559744..559833,559873..560517,560577..561118,561175..561487) II 1 NT_166528.1 Remark: the N-terminal part of the protein shows similarity to unknown transport proteins with an aquaporin domain.; Remark: the similarity is only in the C-terminal part of the protein and shows in this part similarity to apuaporins.; Similarity: belongs to the major intrinsic protein family.; Title: similarity to aquaporin 3 AQP3 - Homo sapiens; See PMID 7558005; uncharacterized protein 561487 4986683 An13g02350 Aspergillus niger uncharacterized protein XP_059602111.1 558778 D 5061 CDS An13g02360 84592836 complement(562120..564033) II 1 NT_166528.1 Title: weak similarity to ankyrin 1 Ank-1 - Mus musculus; uncharacterized protein 564033 84592836 An13g02360 Aspergillus niger uncharacterized protein XP_059602112.1 562120 R 5061 CDS An13g02370 4986685 complement(join(564667..565299,565355..565641,565689..565989,566141..566338)) II 1 NT_166528.1 Remark: probable zinc-finger protein.; Title: strong similarity to hypothetical protein EAA72710.1 - Gibberella zeae; uncharacterized protein 566338 4986685 An13g02370 Aspergillus niger uncharacterized protein XP_059602113.1 564667 R 5061 CDS An13g02380 4986686 complement(join(567432..568245,568299..568636)) II 1 NT_166528.1 Title: weak similarity to hypothetical NADH dehydrogenase subunit 2 ND2 - Lophognathus longirostris; uncharacterized protein 568636 4986686 An13g02380 Aspergillus niger uncharacterized protein XP_001396376.1 567432 R 5061 CDS An13g02390 4986687 join(569483..569805,569881..570015,570155..570716,570766..570870,570917..571525) II 1 NT_166528.1 Remark: also similarity to Neisseria gonorrheae ORF 097 patent WO9957280-A2.; Remark: the disruption of FLU1 in C. albicans had only a slight effect on fluconazole susceptibility; however, it resulted in hypersusceptibility to mycophenolic acid,thus suggesting that this compound could be a substrate for the protein encoded by FLU1.; Title: similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353; uncharacterized protein 571525 4986687 An13g02390 Aspergillus niger uncharacterized protein XP_059602114.1 569483 D 5061 CDS An13g02400 4986688 join(572742..572867,572926..573510,573556..573707,573756..573929,573983..574324,574359..574830) II 1 NT_166528.1 Remark: nirA mediates pathway-specific nitrate assimilation in Aspergillus nidulans.; Remark: the ORF is about 200 amino acids shorter than nirA of A. nidulans.; Similarity: to unassigned GAL4-type zinc cluster proteins.; Title: similarity to nitrate assimilation regulatory protein nirA - Aspergillus nidulans; nucleus; See PMID 1756977; See PMID 1922075; uncharacterized protein 574830 4986688 An13g02400 Aspergillus niger uncharacterized protein XP_059602115.1 572742 D 5061 CDS An13g02410 4986689 join(575622..575825,575897..576011,576060..576337,576389..576667,576717..576827,576880..577080) II 1 NT_166528.1 Title: weak similarity to hypothetical cation transporter DRA0361 - Deinococcus radiodurans; uncharacterized protein 577080 4986689 An13g02410 Aspergillus niger uncharacterized protein XP_059602116.1 575622 D 5061 CDS An13g02420 4986690 complement(join(578654..578950,579021..579119,579195..579569)) II 1 NT_166528.1 Title: strong similarity to hypothetical protein EAA54802.1 - Magnaporthe grisea; uncharacterized protein 579569 4986690 An13g02420 Aspergillus niger uncharacterized protein XP_001396380.1 578654 R 5061 CDS An13g02430 4986691 join(581407..581692,581747..582131,582204..582382,582465..584200,584262..587504,587589..588347,588533..588555,588682..588685,588717..588911) II 1 NT_166528.1 Remark: PKS1 is a multifunctional polyketide synthase (PKS) with six catalytic domains arranged in the following order, starting at the N terminus: beta-ketoacyl synthase, acyltransferase, dehydratase, enoyl reductase,beta-ketoacyl reductase, and acyl carrier protein.; Remark: PKS1 is involved in production of the virulence factor T-toxin.; Remark: putative part of the lovastatin biosynthesis gene cluster as seen in Aspergillus terreus.; Similarity: shows also strong similarity to polyketide synthases of different organisms.; Title: strong similarity to polyketide synthase PKS1 - Cochliobolus heterostrophus; See PMID 8953776; See PMID 7500937; uncharacterized protein 588911 4986691 An13g02430 Aspergillus niger uncharacterized protein XP_001396381.3 581407 D 5061 CDS An13g02450 4986693 join(589631..591609,591742..591970) II 1 NT_166528.1 Title: strong similarity to hypothetical protein AAO76127.1 - Bacteroides thetaiotaomicron; uncharacterized protein 591970 4986693 An13g02450 Aspergillus niger uncharacterized protein XP_001396382.3 589631 D 5061 CDS An13g02460 4986694 join(593273..593554,593601..593862,593903..596085,596181..596570) II 1 NT_166528.1 Similarity: to nonribosomal peptide synthetases and polyketide synthetases.; Title: similarity to nonribosomal peptide synthase MxcG - Stigmatella aurantiaca; See PMID 11029592; uncharacterized protein 596570 4986694 An13g02460 Aspergillus niger uncharacterized protein XP_059602117.1 593273 D 5061 CDS An13g02470 84592837 join(596998..597321,597368..597385) II 1 NT_166528.1 hypothetical protein 597385 84592837 An13g02470 Aspergillus niger hypothetical protein XP_059602118.1 596998 D 5061 CDS An13g02480 4986696 complement(join(597568..598565,598625..598877,598926..598976,599024..599161,599219..599249,599298..599404)) II 1 NT_166528.1 Catalytic activity: N1-acetylspermine + O2 + H2O = N1-acetylspermidine + 3-aminopropanal + H2O2.; Remark: polyamine oxidase catalyses the oxidation of the secondary amino group of spermine, spermidine and their acetyl derivatives. The enzyme plays an important role in the regulation of polyamine intracellular concentration and is a member of the family of flavin-containing amine oxidases.; Similarity: belongs to amine oxidase (flavin-containing) proteins.; Title: strong similarity to polyamine oxidase PAO -Zea mays; See PMID 9598979; See PMID 10089528; uncharacterized protein 599404 4986696 An13g02480 Aspergillus niger uncharacterized protein XP_001396385.1 597568 R 5061 CDS An13g02500 84592838 join(600562..600574,600756..600809,600891..601004,601155..601401,601478..601681,601773..601928,602282..602348,602459..602566,602646..602732,602833..602882,602952..603061,603087..603367) II 1 NT_166528.1 hypothetical protein 603367 84592838 An13g02500 Aspergillus niger hypothetical protein XP_059602119.1 600562 D 5061 CDS An13g02510 4986699 join(603534..603627,603681..603961,604011..604622) II 1 NT_166528.1 Remark: members of the genus Aspergillus are opportunistic pathogens for cold- and warm-blooded animals. They are associated with an impressive spectrum of diseases in humans, ranging from benign colonization of the lung to life-threatening diseases such as invasive aspergillosis or allergic bronchopulmonary aspergillosis (ABPA).; Remark: rAsp f 9 Aspergillus fumigatus is one of those allergens. It shows similarity to various bacterial beta-glucanases and eukaryotic endotransglycosidases.; Title: strong similarity to allergen rAsp f 9 -Aspergillus fumigatus; See PMID 9482698; uncharacterized protein 604622 4986699 An13g02510 Aspergillus niger uncharacterized protein XP_001396387.1 603534 D 5061 CDS An13g02520 84592839 complement(join(604765..604941,605084..605106,605174..605273,605309..605389,605460..605462)) II 1 NT_166528.1 hypothetical protein 605462 84592839 An13g02520 Aspergillus niger hypothetical protein XP_059602120.1 604765 R 5061 CDS An13g02530 4986701 join(606003..606435,606501..606727) II 1 NT_166528.1 Catalytic activity: H2CO3 = CO2 + H2O.; Pathway: nitrogen metabolism.; Remark: most of the N. gonorrhoeae CAH seems to be produced as a soluble protein located in the periplasm of E. coli. The enzyme is homologous to carbonic anhydrases from the animal kingdom; it is an alpha-carbonic anhydrase. A comparison with the amino acid sequences of human carbonic anhydrases I and II suggests that the secondary structures are essentially intact in the bacterial enzyme but that several loops are much shorter than in the human forms.; Similarity: belongs to the carbonic anhydrase family.; Title: similarity to carbonic anhydrase CAH -Neisseria gonorrhoeae; See PMID 9108244; See PMID 9761692; See PMID 11248679; uncharacterized protein 606727 4986701 An13g02530 Aspergillus niger uncharacterized protein XP_001396389.1 606003 D 5061 CDS An13g02540 4986702 join(607420..607457,607512..607906,607973..608319) II 1 NT_166528.1 Remark: alternative names are GTT1, YIR038c.; Remark: subcellular fractionation demonstrated that Gtt1p associates with the endoplasmic reticulum. Expression of GTT1 is induced after diauxic shift and remains high throughout the stationary phase.; Remark: the glutathione S-transferases (GSTs) represent a significant group of detoxification enzymes that play an important role in drug resistance in all eukaryotic species.; Title: strong similarity to glutathione S-transferase Gtt1 - Saccharomyces cerevisiae; See PMID 9792709; uncharacterized protein 608319 4986702 An13g02540 Aspergillus niger uncharacterized protein XP_001396390.1 607420 D 5061 CDS An13g02550 84592840 complement(join(608776..609259,609498..609582,609674..609767)) II 1 NT_166528.1 hypothetical protein 609767 84592840 An13g02550 Aspergillus niger hypothetical protein XP_059602121.1 608776 R 5061 CDS An13g02560 84592841 complement(join(609821..610036,610125..610286,610389..610445)) II 1 NT_166528.1 hypothetical protein 610445 84592841 An13g02560 Aspergillus niger hypothetical protein XP_059602122.1 609821 R 5061 CDS An13g02570 84592842 complement(join(611100..611345,611418..611789)) II 1 NT_166528.1 Title: weak similarity to hypothetical protein encoded by An14g02770 - Aspergillus niger; uncharacterized protein 611789 84592842 An13g02570 Aspergillus niger uncharacterized protein XP_059602123.1 611100 R 5061 CDS An13g02580 84592843 complement(join(612073..612225,612451..612567,612883..612974,613116..613191,613365..613433,613504..613614)) II 1 NT_166528.1 hypothetical protein 613614 84592843 An13g02580 Aspergillus niger hypothetical protein XP_059602124.1 612073 R 5061 CDS An13g02590 4986707 join(613978..614152,614207..614822,614883..615125,615197..615419,615533..615592) II 1 NT_166528.1 Function: low-affinity glucose transporter. Can function as a sensor that generates an intracellular signal in the presence of high level of glucose. Required for maximal expression of the high glucose-induced hxt1 protein.; Remark: Rgt2p is a high glucose-sensing counterpart to Snf3p.; Remark: alternative name is YDL138w.; Similarity: belongs to the sugar transporter family.; Title: similarity to glucose permease Rgt2 -Saccharomyces cerevisiae; See PMID 8901598; uncharacterized protein 615592 4986707 An13g02590 Aspergillus niger uncharacterized protein XP_059602125.1 613978 D 5061 CDS An13g02600 4986709 complement(join(615853..615896,615930..616012,616141..616267,616329..616385,616438..617154,617209..617446)) II 1 NT_166528.1 Remark: all other found dioxygenases are exept the YLL057c 100 amino acids shorter.; Remark: purified recombinant yeast protein YLL057c is shown to be an Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase.; Similarity: belongs to the tfda family of dioxygenases.; Title: strong similarity to Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase YLL057c -Saccharomyces cerevisiae; See PMID 10482536; See PMID 11223942; uncharacterized protein 617446 4986709 An13g02600 Aspergillus niger uncharacterized protein XP_059602126.1 615853 R 5061 CDS An13g02610 4986710 complement(join(618058..618111,618359..618370,618775..618833,618883..619591)) II 1 NT_166528.1 Title: similarity to hypothetical protein EAA77948.1 - Gibberella zeae; uncharacterized protein 619591 4986710 An13g02610 Aspergillus niger uncharacterized protein XP_001396397.3 618058 R 5061 CDS An13g02620 4986711 complement(join(620128..620176,620318..620556,620622..621303,621367..621478,621533..621792,621851..621892,621950..622260)) II 1 NT_166528.1 Remark: also strong similarity to S. lividans proteinase (slpE).; Remark: impaired expression of such proteases by Streptomyces hosts improves the quality, quantity and stability of exogenous gene products.; Remark: strong similarity to S. lividans protease P5-6 patent WO9517512-A.; Title: strong similarity to proteinase P5-6 from patent WO9517512-A - Streptomyces lividans; See PMID 7592364; uncharacterized protein 622260 4986711 An13g02620 Aspergillus niger uncharacterized protein XP_001396398.3 620128 R 5061 CDS An13g02630 84592844 join(622731..622940,623502..623657,624223..624354) II 1 NT_166528.1 hypothetical protein 624354 84592844 An13g02630 Aspergillus niger hypothetical protein XP_059602127.1 622731 D 5061 CDS An13g02640 4986713 complement(624877..627177) II 1 NT_166528.1 Catalytic activity: L-phenylalanine = trans-cinnamate + NH3.; Pathway: tyrosine metabolism; phenylalanine metabolism; nitrogen metabolism; alkaloid biosynthesis II.; Remark: PAL is used for the prodn. of L-phenylalanine from cinnamic acid and ammonia.; Remark: also strong similarity to L-phenylalanine ammonia lyase (PAL) from Rhodosporidium turoloides patent EP278706-A.; Remark: the active sites of the enzyme phenylalanine ammonia-lyase (Pal) from Rhodosporidium toruloides contains a dehydroalanine residue that is believed to be essential for catalytic activity.; Similarity: belongs to the histidine ammonia-lyase family.; Title: strong similarity to phenylalanine ammonia-lyase Pal - Rhodosporidium toruloides; See PMID 8200528; See PMID 1368015; uncharacterized protein 627177 4986713 An13g02640 Aspergillus niger uncharacterized protein XP_059602128.1 624877 R 5061 CDS An13g02650 84592845 complement(join(627443..627566,627608..627702,627756..627866,627958..628014,628112..628153,628240..628288,628370..628422)) II 1 NT_166528.1 hypothetical protein 628422 84592845 An13g02650 Aspergillus niger hypothetical protein XP_059602129.1 627443 R 5061 CDS An13g02660 84592846 join(629061..629168,629380..629492,629547..629892,629942..630011,630320..630474,630739..630855,630966..631086,631162..631407,631456..631580) II 1 NT_166528.1 Title: weak similarity to hypothetical N-WASP binding protein WISH - Mus musculus; uncharacterized protein 631580 84592846 An13g02660 Aspergillus niger uncharacterized protein XP_059602130.1 629061 D 5061 CDS An13g02670 4986716 631742..632962 II 1 NT_166528.1 Gene-ID: Arsa-7; Remark: Arsa-7 from A. niger is differentially expressed in the pellet morphology relative to the filamentous morphology.; Remark: putative cell wall protein.; differential expressed Arsa-7 from patent US2003215950-A1-Aspergillus niger 632962 Arsa-7 4986716 Arsa-7 Aspergillus niger differential expressed Arsa-7 from patent US2003215950-A1-Aspergillus niger XP_001396403.1 631742 D 5061 CDS An13g02680 4986717 complement(join(633455..633640,633782..633896,633954..634181,634246..634361,634423..634478,634530..634633,634687..634731,634787..635017,635063..635249,635295..635373,635421..635559,635610..635731,635826..635909)) II 1 NT_166528.1 Remark: Inactivation of ribonucleotide reductase, by either hydroxyurea or a cdc22-M45 mutation, causes liz1(-) cells in G2 to undergo an aberrant mitosis, resulting in chromosome missegregation and late mitotic arrest.; Remark: Liz1p, a fission yeast membrane protein, is required for normal cell division when ribonucleotide reductase is inhibited.; Title: strong similarity to transmembrane transporter liz1p - Schizosaccharomyces pombe; See PMID 9950674; uncharacterized protein 635909 4986717 An13g02680 Aspergillus niger uncharacterized protein XP_059602131.1 633455 R 5061 CDS An13g02690 4986718 complement(join(636475..637272,637332..637478,637530..637803,637850..638052)) II 1 NT_166528.1 Catalytic activity: N,N-dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.; Function: this protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.; Remark: pulmonary microsomes from Rhesus macaque express a flavin-containing monooxygenase (FMO) resembling the FMO2 ortholog from rabbit with respect to immunochemical cross-reactivity and expression in lung, but not liver.; Similarity: belongs to the FMO family.; Title: strong similarity to flavin-containing monooxygenase FMO2 - Macaca mulatta; See PMID 9061021; uncharacterized protein 638052 4986718 An13g02690 Aspergillus niger uncharacterized protein XP_059602132.1 636475 R 5061 CDS An13g02700 4986719 join(638834..639277,639348..639889,639941..640112) II 1 NT_166528.1 Catalytic activity: taurine + 2-oxoglutarate + O2 = sulfite + aminoacetaldehyde + succinate + CO2.; EC:1.14.11.17.; Remark: taurine/alpha-ketoglutarate dioxygenase (TauD), a member of the broad class of non-heme Fe(II) oxygenases, converts taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde while decomposing alpha-ketoglutarate (alphaKG) to form succinate and CO(2).; Remark: the Escherichia coli tauD gene is required for the utilization of taurine (2-aminoethanesulfonic acid) as a sulfur source and is expressed only under conditions of sulfate starvation.; Similarity: belongs to the TFDA family.; Title: similarity to taurine dioxygenase,2-oxoglutarate-dependent tauD - Escherichia coli; See PMID 9287300; See PMID 10563813; uncharacterized protein 640112 4986719 An13g02700 Aspergillus niger uncharacterized protein XP_001396406.1 638834 D 5061 CDS An13g02710 4986720 complement(join(640713..641213,641278..641553)) II 1 NT_166528.1 Title: weak similarity to hypothetical protein YIL064w - Saccharomyces cerevisiae; uncharacterized protein 641553 4986720 An13g02710 Aspergillus niger uncharacterized protein XP_001396407.1 640713 R 5061 CDS An13g02720 84592847 complement(join(642151..642363,642469..642507,642609..642712,642818..642892,642981..643102,643246..643325)) II 1 NT_166528.1 Title: weak similarity to hypothetical urokinase plasminogen activator receptor UPAR - Aotus trivirgatus; uncharacterized protein 643325 84592847 An13g02720 Aspergillus niger uncharacterized protein XP_059602133.1 642151 R 5061 CDS An13g02730 4986722 join(643385..643487,643552..643691) II 1 NT_166528.1 Remark: the ORF is putative 5' longer.; Title: strong similarity to EST an_3461 -Aspergillus niger; uncharacterized protein 643691 4986722 An13g02730 Aspergillus niger uncharacterized protein XP_001396409.1 643385 D 5061 CDS An13g02740 84592848 join(644735..644837,644944..645027,645048..645163,645211..645249) II 1 NT_166528.1 hypothetical protein 645249 84592848 An13g02740 Aspergillus niger hypothetical protein XP_059602134.1 644735 D 5061 CDS An13g02760 84592849 complement(join(645611..645714,645775..646028,646251..646336,646396..646644)) II 1 NT_166528.1 hypothetical protein 646644 84592849 An13g02760 Aspergillus niger hypothetical protein XP_059602135.1 645611 R 5061 CDS An13g02770 4986726 join(646895..647040,647096..648029) II 1 NT_166528.1 Remark: D(--)-Mandelate dehydrogenase, the first enzyme of the mandelate pathway in the yeast Rhodotorula graminis, catalyses the NAD(+)-dependent oxidation of D(--)-mandelate to phenylglyoxylate.; Title: strong similarity to D-mandelate dehydrogenase - Rhodotorula graminis; See PMID 8411179; See PMID 1731758; uncharacterized protein 648029 4986726 An13g02770 Aspergillus niger uncharacterized protein XP_001396412.1 646895 D 5061 CDS An13g02780 4986727 complement(join(648092..648448,648495..648802,648870..649089)) II 1 NT_166528.1 Remark: ADD is a cytoskeletal heterodimeric protein which may be involved in cellular signal transduction and interacts with other membrane skeleton proteins which affect ion transport across the cell membrane.; Remark: in rat, mouse and human the adducins are playing a substantial role in hypertension.; Remark: the similarity of the ORF to proteins of higher organisms concerns the N-terminal region of adducins, however the ORF shows also homology to aldolases from lower eucaryotes over its whole lenght.; Title: similarity to alpha-adducin alpha-ADD -Rattus norvegicus; See PMID 8543181; See PMID 9678591; uncharacterized protein 649089 4986727 An13g02780 Aspergillus niger uncharacterized protein XP_001396413.3 648092 R 5061 CDS An13g02790 4986728 complement(join(649509..649676,649785..649845,649897..649972,650019..651269,651320..651437)) II 1 NT_166528.1 Remark: impaired expression of Tap by Streptomyces hosts improves the quality, quantity and stability of exogenous gene products.; Remark: strong similarity to S. lividans protease Tap patent WO9517512-A.; Remark: tripeptidyl aminopeptidase (Tap) from Streptomyces lividans is responsible for the major amino-terminal degradative activity in culture broths of S. lividans strains.; Title: strong similarity to tripeptidylaminopeptidase Tap - Streptomyces lividans; See PMID 7487044; uncharacterized protein 651437 4986728 An13g02790 Aspergillus niger uncharacterized protein XP_059602136.1 649509 R 5061 CDS An13g02800 84592850 join(652660..652761,652841..652937,653124..653235,653318..653490,653564..653742,653832..653990) II 1 NT_166528.1 hypothetical protein 653990 84592850 An13g02800 Aspergillus niger hypothetical protein XP_059602137.1 652660 D 5061 CDS An13g02810 4986730 join(654141..654350,654395..655849,655899..655915,655964..656041,656094..656202) II 1 NT_166528.1 Remark: ENB1 S. cerevisiae encodes a transporter protein (Enb1p), which specifically recognizes and transports enterobactin. Enterobactin is a catecholate-type siderophore produced by several enterobacterial genera grown in severe iron deprivation.; Similarity: belongs to the major facilitator super family (MFS).; Title: strong similarity to siderophore-iron transporter for enterobactin Enb1 - Saccharomyces cerevisiae; See PMID 10831226; uncharacterized protein 656202 4986730 An13g02810 Aspergillus niger uncharacterized protein XP_059602138.1 654141 D 5061 CDS An13g02820 4986731 complement(656310..657143) II 1 NT_166528.1 Catalytic activity: triacylglycerol + H2O = diacylglycerol + a carboxylate; Diacylglycerol + H2O = monoacylglycerol + a carboxylate.; Pathway: glycerolipid metabolism.; Remark: gehA, P. acnes was overexpressed in E. coli under the control of the bacteriophage T7 promoter, and the corresponding polypeptide was found to be present in insoluble aggregates. Active lipase was produced when the overexpressing strain was incubated at a reduced temperature in the presence of sucrose.; Similarity: belongs to the triacylglycerol lipase family.; Title: strong similarity to triacylglycerol lipase gehA - Propionibacterium acnes; See PMID 9168624; uncharacterized protein 657143 4986731 An13g02820 Aspergillus niger uncharacterized protein XP_001396417.1 656310 R 5061 CDS An13g02830 84592851 join(658300..658516,658610..658743,658840..658957,659043..659212) II 1 NT_166528.1 hypothetical protein 659212 84592851 An13g02830 Aspergillus niger hypothetical protein XP_059602139.1 658300 D 5061 CDS An13g02840 84592852 complement(join(659927..660187,660478..660619,660879..660967)) II 1 NT_166528.1 hypothetical protein 660967 84592852 An13g02840 Aspergillus niger hypothetical protein XP_059602140.1 659927 R 5061 CDS An13g02850 84592853 join(661239..661310,661435..661545,661596..661946) II 1 NT_166528.1 hypothetical protein 661946 84592853 An13g02850 Aspergillus niger hypothetical protein XP_059602141.1 661239 D 5061 CDS An13g02860 84592854 join(662068..662143,662229..662292,662369..662455,662571..662690,663171..663262,663496..663557,663627..663769,663864..664019,664068..664220,664337..664508) II 1 NT_166528.1 hypothetical protein 664508 84592854 An13g02860 Aspergillus niger hypothetical protein XP_059602142.1 662068 D 5061 CDS An13g02870 84592855 complement(join(664652..664918,664992..665129)) II 1 NT_166528.1 hypothetical protein 665129 84592855 An13g02870 Aspergillus niger hypothetical protein XP_059602143.1 664652 R 5061 CDS An13g02880 4986737 complement(667185..669743) II 1 NT_166528.1 Title: strong similarity to hypothetical integral membrane protein SPAC16A10.01 - Schizosaccharomyces pombe; uncharacterized protein 669743 4986737 An13g02880 Aspergillus niger uncharacterized protein XP_001396423.1 667185 R 5061 CDS An13g02890 84592856 complement(join(669777..670048,670230..670360,670442..670630,670697..670780,670887..670903)) II 1 NT_166528.1 Remark: the predicted ORF is questionable due to its intron-exon structure and proximity to the next N-terminally encoded ORF.; Title: questionable ORF; uncharacterized protein 670903 84592856 An13g02890 Aspergillus niger uncharacterized protein XP_059602144.1 669777 R 5061 CDS An13g02900 84592857 join(670987..671143,671247..671449) II 1 NT_166528.1 hypothetical protein 671449 84592857 An13g02900 Aspergillus niger hypothetical protein XP_059602145.1 670987 D 5061 CDS An13g02910 84592858 complement(join(671551..671859,671926..672399,672520..672732)) II 1 NT_166528.1 hypothetical protein 672732 84592858 An13g02910 Aspergillus niger hypothetical protein XP_059602146.1 671551 R 5061 CDS An13g02920 84592859 join(672771..672887,672942..673032,673131..673276,673383..673604,673814..673912) II 1 NT_166528.1 Function: due to the restricted similarity to lovF of A. terreus it is assumed, that the predicted ORF encodes another, e. g. A. niger-specific polyketide synthase with an N-terminal beta-ketoacyl synthase domain containing an active site cysteine.; Remark: lovF polyketid synthase of A. terreus is encoded in a lovastatin biosynthesis cluster.; Remark: polyketid biosynthesis in bacteria and fungi is related to fatty acid metabolism and results in wide range of biologically active secondary metabolites, e. g. lovastatin, which inhibits HMG-CoA reductase.; Similarity: the predicted ORF is only 1/10 as long as lovF of A. terreus and its similarity to lovF is restricted to the 60 N-terminal amino acids.; Title: similarity to polyketide synthase lovF -Aspergillus terreus; See PMID 10334994; See PMID 10381407; uncharacterized protein 673912 84592859 An13g02920 Aspergillus niger uncharacterized protein XP_059602147.1 672771 D 5061 CDS An13g02940 4986743 complement(675547..676629) II 1 NT_166528.1 Function: lovC of A. terreus is thought to be responsible for the three enoyl reductions predicted to be necessary for the formation of dihydromonacolin L, a intermediate of lovastatin production.; Remark: lovC of A. terreus is encoded in a lovastatin biosynthesis cluster, which also contains other proteins involved in polyketide synthesis, e. g. lovB and lovF.; Remark: lovC of A. terreus is involved in polyketide synthesis, that is related to fatty acid metabolism and results in wide range of biologically active secondary metabolites, e. g. lovastatin, which inhibits HMG-CoA reductase.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994; See PMID 10381407; uncharacterized protein 676629 4986743 An13g02940 Aspergillus niger uncharacterized protein XP_001396429.1 675547 R 5061 CDS An13g02950 84592860 join(677958..678111,678186..678252,678320..678416) II 1 NT_166528.1 hypothetical protein 678416 84592860 An13g02950 Aspergillus niger hypothetical protein XP_059602148.1 677958 D 5061 CDS An13g02960 4986745 join(678773..679403,679475..>681555) II 1 NT_166528.1 Function: lovB of A. terreus is involved in polyketide synthesis, that is related to fatty acid metabolism and results in wide range of biologically active secondary metabolites, e. g. lovastatin, which inhibits HMG-CoA reductase.; Remark: lovB of A. terreus is encoded in a lovastatin biosynthesis cluster, which also contains other proteins involved in polyketide synthesis, e. g. lovC and lovF.; Remark: the predicted ORF is C-terminally truncated due to the contig border.; Similarity: the predicted ORF shows comparable similarity to lovB and lovF of A. terreus, therefore it is assumed, that it may encode an A. niger-specific polyketide synthase.; Title: strong similarity to lovastatin nonaketide synthase lovB - Aspergillus terreus [truncated ORF]; See PMID 10381407; See PMID 11378962; uncharacterized protein 681555 4986745 An13g02960 Aspergillus niger uncharacterized protein XP_001396431.3 678773 D 5061 CDS An13g02970 84592861 681659..682015 II 1 NT_166528.1 Title: weak similarity to hypothetical protein encoded by An08g03800 - Aspergillus niger; uncharacterized protein 682015 84592861 An13g02970 Aspergillus niger uncharacterized protein XP_059602149.1 681659 D 5061 CDS An13g02980 4986747 complement(join(682904..683392,683455..683508)) II 1 NT_166528.1 Title: similarity to hypothetical protein encoded by An01g08440 - Aspergillus niger; uncharacterized protein 683508 4986747 An13g02980 Aspergillus niger uncharacterized protein XP_001396433.1 682904 R 5061 CDS An13g02990 4986748 join(684553..685223,685283..686054,686111..686236) II 1 NT_166528.1 Similarity: the predicted ORF is rich in proline,glycine and glutamine, therefore it shows unspecific similarity to some proteins with a high content of these amino acids.; Title: similarity to hypothetical protein EAA71271.1 - Gibberella zeae; uncharacterized protein 686236 4986748 An13g02990 Aspergillus niger uncharacterized protein XP_059602150.1 684553 D 5061 CDS An13g03000 4986749 complement(join(686802..687989,688066..688467)) II 1 NT_166528.1 Catalytic activity: ALK1 of Y. lipolytica catalyses RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein.; Function: ALK1 of Y. lipolytica is probably the major cytochrome P450 protein to metabolize short-chain n-alkanes such as decane and dodecane in Y. lipolytica.; Induction: ALK1 of Y. lipolytica is induced by n-tetradecane and repressed by glycerol.; Phenotype: an ALK1 of Y. lipolytica gene disruptant did not grow well on n-decane, but grew on longer-chain n-alkanes such as hexadecane as a sole carbon source.; Title: strong similarity to n-alkane-inducible cytochrome P450 protein ALK1 - Yarrowia lipolytica; See PMID 9848230; See PMID 10953079; uncharacterized protein 688467 4986749 An13g03000 Aspergillus niger uncharacterized protein XP_001396435.1 686802 R 5061 CDS An13g03010 84592862 join(689920..690084,690318..690406,690483..690559,690637..690764) II 1 NT_166528.1 Remark: the intron-exon structure is not optimal.; hypothetical protein 690764 84592862 An13g03010 Aspergillus niger hypothetical protein XP_059602151.1 689920 D 5061 CDS An13g03020 84592863 join(691699..691738,691803..691868,692031..692185) II 1 NT_166528.1 Remark: the ORF has an intron-exon structure, which is not typical for A. niger proteins and is only 86 amino acids long.; Title: questionable ORF; uncharacterized protein 692185 84592863 An13g03020 Aspergillus niger uncharacterized protein XP_059602152.1 691699 D 5061 CDS An13g03030 4986752 join(693562..693621,693731..695848) II 1 NT_166528.1 Title: similarity to hypothetical protein CAB91400.2 - Neurospora crassa [putative sequencing error]; putative sequencing error; uncharacterized protein 695848 4986752 An13g03030 Aspergillus niger uncharacterized protein XP_001396438.1 693562 D 5061 CDS An13g03040 4986753 complement(696460..700707) II 1 NT_166528.1 Function: esyn1 of F. scirpi is a multifunctional enzyme catalysing n-methyl depsipeptide formation.; Similarity: esyn1 of F. scirpi is 3131 amino acids long and the predicted ORF 1415 aa.; Similarity: the ORF show similarity to several peptide synthetases from different species.; Title: strong similarity to enniatin synthase esyn1 - Fusarium scirpi; See PMID 7601090; See PMID 8483420; uncharacterized protein 700707 4986753 An13g03040 Aspergillus niger uncharacterized protein XP_001396439.1 696460 R 5061 CDS An13g03050 4986754 join(701922..702106,702173..702615,702689..702825) II 1 NT_166528.1 Title: weak similarity to hypothetical protein encoded by An04g04070 - Aspergillus niger; uncharacterized protein 702825 4986754 An13g03050 Aspergillus niger uncharacterized protein XP_001396440.3 701922 D 5061 CDS An13g03060 4986755 complement(join(704371..706893,706950..708689)) II 1 NT_166528.1 Induction: the transcription of atrB from A. nidulans is strongly enhanced by treatment with several drugs, including antibiotics, azole fungicides and plant defense toxins.; Title: strong similarity to ATP-binding cassette multidrug transport protein atrB - Aspergillus nidulans; See PMID 9180695; uncharacterized protein 708689 4986755 An13g03060 Aspergillus niger uncharacterized protein XP_001396441.1 704371 R 5061 CDS An13g03070 84592864 complement(join(709365..709556,709639..709662,709775..709822,709880..709978,710059..710264,710337..710376)) II 1 NT_166528.1 hypothetical protein 710376 84592864 An13g03070 Aspergillus niger hypothetical protein XP_059602153.1 709365 R 5061 CDS An13g03080 4986757 complement(join(711339..711441,711714..711844)) II 1 NT_166528.1 Remark: the ORF has an intron-exon structure, which is not typical for A. niger proteins and is only 77 amino acids long.; Title: questionable ORF; uncharacterized protein 711844 4986757 An13g03080 Aspergillus niger uncharacterized protein XP_059602154.1 711339 R 5061 CDS An13g03090 84592865 join(712280..712417,712539..712733,712887..713174) II 1 NT_166528.1 Remark: the ORF contains introns, that are suboptimal long.; hypothetical protein 713174 84592865 An13g03090 Aspergillus niger hypothetical protein XP_059602155.1 712280 D 5061 CDS An13g03100 4986759 complement(join(714126..714617,714663..715617,715684..715750,715845..715881)) II 1 NT_166528.1 Function: DUK1 of S. cerevisiae is a channel permeable to outward flow of K+ ions.; Remark: DUK1 of S. cerevisiae is also called TOK1,YJL093C, YKC1 or YORK.; Repression: in excised membrane patches external divalent cations block DUK1 of S. cerevisiae in a voltage-dependent manner, and their removal allows inward channel current.; Title: strong similarity to outward-rectifier potassium channel Duk1 - Saccharomyces cerevisiae; See PMID 10089235; See PMID 7651518; uncharacterized protein 715881 4986759 An13g03100 Aspergillus niger uncharacterized protein XP_059602156.1 714126 R 5061 CDS An13g03110 4986760 complement(join(716256..717597,717665..717852)) II 1 NT_166528.1 Function: TNA1 of S. cerevisiae is a high affinity plasma membrane permease, which belongs to the allantoate permease family and is involved in the uptake of nicotinic acid.; Phenotype: the deletion of TNA1 in S. cerevisiae prevents growth at low nicotinic acid concentration.; Remark: the systematic name for TNA1 of S. cerevisiae is YGR260W.; Similarity: the ORF overlaps with A. niger EST (EMBLEST:AN784) Nig091.; Similarity: the ORF shows similarity to several transporters with different substrate specificities.; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563; See PMID 10984621; uncharacterized protein 717852 4986760 An13g03110 Aspergillus niger uncharacterized protein XP_001396446.1 716256 R 5061 CDS An13g03120 84592866 complement(join(718574..718627,718738..719053,719148..719182)) II 1 NT_166528.1 hypothetical protein 719182 84592866 An13g03120 Aspergillus niger hypothetical protein XP_059602157.1 718574 R 5061 CDS An13g03130 4986762 join(720936..721121,721170..721304,721356..722126) II 1 NT_166528.1 Similarity: the predicted ORF is 125 amino acids longer at the C-terminus than the putative cysteine-binding protein fliY of H. volcanii.; Title: similarity to hypothetical cysteine-binding protein fliY - Haloferax volcanii; uncharacterized protein 722126 4986762 An13g03130 Aspergillus niger uncharacterized protein XP_001396448.3 720936 D 5061 CDS An13g03140 4986763 join(723329..723621,723674..723729,723782..723841,723905..723976,724039..724122,724195..724367) II 1 NT_166528.1 Remark: the EC number of endo-beta-1,4-glucanase is 3. 2. 1. 4.; Similarity: the homology is restricted to the N-terminal part of celA1 from S. halstedii.; Title: weak similarity to endo-beta-1,4-glucanase celA1 - Streptomyces halstedii; See PMID 1400190; uncharacterized protein 724367 4986763 An13g03140 Aspergillus niger uncharacterized protein XP_001396449.1 723329 D 5061 CDS An13g03150 4986764 complement(join(724940..724977,725027..725589,725662..726224)) II 1 NT_166528.1 Catalytic activity: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide +CO2.; Catalytic activity: the E1 component of BCKDH requires thiamin pyrophosphate as a cofactor.; Complex: the E1 component of BCKDH is composed of two alpha and two beta chains.; Function: the E1 component of BCKDH catalyses the oxidative decarboxylation of branched-chain alpha-ketoacids, which are derived from branched-chain amino acids by transamination.; Pathway: BCKDH is a key enzyme in the catabolism of branched-chain amino acids.; Title: strong similarity to Arp2/3 complex 34 kD subunit BCKDH - Gallus gallus; localisation:mitochondrion; See PMID 11168412; uncharacterized protein 726224 4986764 An13g03150 Aspergillus niger uncharacterized protein XP_001396450.1 724940 R 5061 CDS An13g03160 4986765 complement(join(726925..728226,728277..728750)) II 1 NT_166528.1 Function: astA of E. rectale catalyzes the transfer of a sulfate moiety from an aromatic sulfate ester to another aromatic alcohol.; Title: similarity to arylsulfate sulfotransferase astA - Eubacterium rectale IIIH; See PMID 11320417; uncharacterized protein 728750 4986765 An13g03160 Aspergillus niger uncharacterized protein XP_001396451.1 726925 R 5061 CDS An13g03170 84592867 complement(join(728981..729181,729305..729395,729561..729697)) II 1 NT_166528.1 hypothetical protein 729697 84592867 An13g03170 Aspergillus niger hypothetical protein XP_059602158.1 728981 R 5061 CDS An13g03180 84592868 join(731128..731318,731390..731564,731652..731775,732059..732178,732337..732426,732471..732535,732578..732667,732742..732804) II 1 NT_166528.1 hypothetical protein 732804 84592868 An13g03180 Aspergillus niger hypothetical protein XP_059602159.1 731128 D 5061 CDS An13g03190 4986768 complement(join(733238..733509,733558..733935,734121..734263,734366..734409)) II 1 NT_166528.1 Catalytic activity: Rnh1 of M. musculus cleaves RNA-DNA hybrids at the RNA:DNA junction generating a 3'-hydroxyl-terminated oligoribonucleotide and a 5'-monophosphate-terminated polydeoxyribonucleotide.; Function: a role of RNase H1 in the removal of RNA primers during lagging-strand DNA biosynthesis is proposed.; Title: strong similarity to ribonuclease (RNase) H1 Rnh1 - Mus musculus; nucleus; See PMID 9799596; See PMID 10567561; uncharacterized protein 734409 4986768 An13g03190 Aspergillus niger uncharacterized protein XP_059602160.1 733238 R 5061 CDS An13g03200 84592869 complement(734523..734780) II 1 NT_166528.1 Remark: the ORF is short in length (85 amino acids).; hypothetical protein 734780 84592869 An13g03200 Aspergillus niger hypothetical protein XP_059602161.1 734523 R 5061 CDS An13g03210 84592870 complement(join(735303..735794,735874..735927)) II 1 NT_166528.1 hypothetical protein 735927 84592870 An13g03210 Aspergillus niger hypothetical protein XP_059602162.1 735303 R 5061 CDS An13g03220 4986771 join(736414..736528,736599..736788,736850..737960) II 1 NT_166528.1 Function: TPO1 of S. cerevisiae facilitates the uptake of the polyamines spermine and spermidine into vacuolar vesicles.; Function: TPO1 of S. cerevisiae is involved in the regulation of the spermidine and spermine content of the cytoplasm.; Remark: the systematic gene name of TPO1 in S. cerevisiae is YLL028w.; Similarity: belongs to the major facilitator superfamily (MFS-MDR).; Similarity: shows an even stronger similarity to a protein involved in cepahalosporin C biosynthesis of protein patent GENESEQPROT:W14440 which lacks a clear functional description.; Title: strong similarity to polyamine transport protein Tpo1 - Saccharomyces cerevisiae; vacuole; See PMID 9920864; See PMID 11171066; uncharacterized protein 737960 4986771 An13g03220 Aspergillus niger uncharacterized protein XP_001396457.1 736414 D 5061 CDS An13g03230 84592871 complement(join(738267..738649,738733..738817,738902..739541,739614..739953,740056..740288,740362..740603,740679..741077,741156..741331,741421..741451)) II 1 NT_166528.1 Title: similarity to hypothetical transcription regulator SPBC530.11c - Schizosaccharomyces pombe; uncharacterized protein 741451 84592871 An13g03230 Aspergillus niger uncharacterized protein XP_059602163.1 738267 R 5061 CDS An13g03240 4986773 742562..743782 II 1 NT_166528.1 Title: strong similarity to hypothetical protein Z of the rapamycin biosynthetis gene cluster - Streptomyces hygroscopicus; See PMID 8635730; uncharacterized protein 743782 4986773 An13g03240 Aspergillus niger uncharacterized protein XP_001396459.1 742562 D 5061 CDS An13g03250 4986774 complement(join(744238..744917,744980..745675,745737..745884)) II 1 NT_166528.1 Function: RAG1 of K. lactis facilitates the cellular uptake of various sugars including glucose and fructose.; Function: RAG1 of K. lactis is important for fermentative growth.; Induction: RAG1 of K. lactis is inducible by glucose, fructose, mannose, sucrose, raffinose and galactose.; Title: strong similarity to low affinity hexose transporter RAG1 - Kluyveromyces lactis; plasma membrane; See PMID 1603079; See PMID 2402460; uncharacterized protein 745884 4986774 An13g03250 Aspergillus niger uncharacterized protein XP_001396460.1 744238 R 5061 CDS An13g03260 4986775 join(746344..746422,746614..747011,747066..747962) II 1 NT_166528.1 Similarity: homologous to protein of patent database entry GENESEQPROT:B19189.; Title: strong similarity to lipid metabolism protein YGR046w from patent WO200058521-A2 - Saccharomyces cerevisiae; uncharacterized protein 747962 4986775 An13g03260 Aspergillus niger uncharacterized protein XP_059602164.1 746344 D 5061 CDS An13g03270 84592872 complement(748814..749644) II 1 NT_166528.1 Title: similarity to hypothetical protein encoded by An13g03280 - Aspergillus niger; uncharacterized protein 749644 84592872 An13g03270 Aspergillus niger uncharacterized protein XP_059602165.1 748814 R 5061 CDS An13g03280 84592873 complement(join(750124..750782,750860..750962)) II 1 NT_166528.1 Title: similarity to hypothetical protein encoded by An13g03270 - Aspergillus niger; uncharacterized protein 750962 84592873 An13g03280 Aspergillus niger uncharacterized protein XP_059602166.1 750124 R 5061 CDS An13g03290 4986778 752910..753773 II 1 NT_166528.1 Title: strong similarity to hypothetical protein of the paxilline biosynthesis gene cluster paxU - Penicillium paxilli; See PMID 11169115; uncharacterized protein 753773 4986778 An13g03290 Aspergillus niger uncharacterized protein XP_001396464.1 752910 D 5061 CDS An13g03300 4986779 join(754682..754869,754935..755034,755096..755164,755221..755284,755375..755883,755949..755996) II 1 NT_166528.1 Title: strong similarity to hypothetical conserved protein 99H12.80 - Neurospora crassa; uncharacterized protein 755996 4986779 An13g03300 Aspergillus niger uncharacterized protein XP_059602167.1 754682 D 5061 CDS An13g03310 4986780 complement(join(756431..756669,756721..757534,757585..757754,757795..757963,758021..758164)) II 1 NT_166528.1 Remark: alternative name is YGR260w.; Remark: the deletion of YGR260w in a bna1 auxotrophic mutant for nicotinic acid prevents growth at low nicotinic acid concentration. This suggests that YGR260w is necessary for nicotinic acid import into the cell. The direct measurement of nicotinic acid uptake on whole cells demonstrates that YGR260w encodes the yeast high affinity nicotinic acid permease.; Similarity: to Dal5p subfamily of the major facilitator family.; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563; uncharacterized protein 758164 4986780 An13g03310 Aspergillus niger uncharacterized protein XP_059602168.1 756431 R 5061 CDS An13g03320 84592874 complement(join(758898..759239,759296..760641,760688..760856)) II 1 NT_166528.1 Catalytic activity: a 2-oxo acid = an aldehyde + CO2; pyruvate = acetaldehyde + CO2.; Pathway: glycolysis / gluconeogenesis.; Similarity: belongs to the thiamine-diphosphate protein family.; Title: strong similarity to pyruvate decarboxylase (PDC)-2 SEQ ID NO:44292 from patent EP1033405-A2 -Arabidopsis thaliana; uncharacterized protein 760856 84592874 An13g03320 Aspergillus niger uncharacterized protein XP_059602169.1 758898 R 5061 CDS An13g03330 4986781 complement(join(<760902..761136,761191..761444,761496..761565,761624..761800,761856..761938,762000..762035,762082..762186,762231..762306)) II 1 NT_166528.1 Protein sequence is in conflict with the conceptual translation; Catalytic activity: alcohol + NAD+ = aldehyde or ketone + NADH.; Pathway: glycolysis / gluconeogenesis; atty acid metabolism; bile acid biosynthesis; tyrosine metabolism; glycerolipid metabolism.; Remark: Expression of the structural genes for alcohol and aldehyde dehydrogenase, alcA and aldA,respectively, enables the fungus Aspergillus nidulans to grow on ethanol. The pathway-specific transcriptional activator AlcR mediates the induction of ethanol catabolism in the presence of a coinducing compound. Ethanol catabolism is further subject to negative control mediated by the general carbon catabolite repressor CreA.; Remark: putative sequencing error at position 33553 generating a frame shift. 1 bases too much.; Similarity: belongs to the long-chain alcohol dehydrogenases.; Title: strong similarity to alcohol dehydrogenase alcA - Aspergillus nidulans; putative frameshift; See PMID 3297923; See PMID 11102439; uncharacterized protein 762306 4986781 An13g03330 Aspergillus niger uncharacterized protein XP_001396467.3 760902 R 5061 CDS An13g03340 84592875 complement(join(762578..762813,762903..762962,763041..763167)) II 1 NT_166528.1 hypothetical protein 763167 84592875 An13g03340 Aspergillus niger hypothetical protein XP_059602170.1 762578 R 5061 CDS An13g03350 84592876 complement(join(764258..764307,764567..764645,764685..764702,765051..765117,765481..765800)) II 1 NT_166528.1 hypothetical protein 765800 84592876 An13g03350 Aspergillus niger hypothetical protein XP_059602171.1 764258 R 5061 CDS An13g03360 4986785 join(766289..766338,766638..766816,766877..767198,767338..767359) II 1 NT_166528.1 Title: strong similarity to hypothetical protein encoded by An12g09820 - Aspergillus niger; uncharacterized protein 767359 4986785 An13g03360 Aspergillus niger uncharacterized protein XP_059602172.1 766289 D 5061 CDS An13g03370 4986786 join(768114..768356,768423..768992,769060..769590) II 1 NT_166528.1 Catalytic activity: s-adenosyl-l-methionine + sterigmatocystin = s-adenosyl-l-homocysteine + 7-o-methylsterigmatocystin.; Pathway: aflatoxin biosynthesis.; Remark: aflatoxins are polyketide-derived secondary metabolites produced by the fungi Aspergillus flavus and Aspergillus parasiticus. Among the catalytic steps in the aflatoxin biosynthetic pathway, the conversion of sterigmatocystin to O-methylsterigmatocystin and the conversion of dihydrosterigmatocystin to dihydro-O-methylsterigmatocystin are catalyzed by an S-adenosylmethionine-dependent O-methyltransferase.; Remark: omtA of A. parasiticus is also called omt-1.; Title: strong similarity to O-methyltransferase A omtA - Aspergillus parasiticus; See PMID 7557460; See PMID 8285664; See PMID 8434913; uncharacterized protein 769590 4986786 An13g03370 Aspergillus niger uncharacterized protein XP_001396472.1 768114 D 5061 CDS An13g03380 4986787 join(770065..770306,770363..770636,770694..771411,771644..771732) II 1 NT_166528.1 Remark: strong similarity to amino acid sequence of M. vaccae antigen GV-33 patent WO9932634-A2.; Title: strong similarity to amino acid sequence antigen GV-33 from patent WO9932634-A2 - Mycobacterium vaccae; uncharacterized protein 771732 4986787 An13g03380 Aspergillus niger uncharacterized protein XP_001396473.3 770065 D 5061 CDS An13g03390 84592877 complement(join(772401..772529,772581..772644,772728..772807,772886..772933)) II 1 NT_166528.1 hypothetical protein 772933 84592877 An13g03390 Aspergillus niger hypothetical protein XP_059602173.1 772401 R 5061 CDS An13g03400 84592878 join(773148..773366,773419..773710,773784..774193) II 1 NT_166528.1 Title: strong similarity to hypothetical protein encoded by An03g03680 - Aspergillus niger; uncharacterized protein 774193 84592878 An13g03400 Aspergillus niger uncharacterized protein XP_059602174.1 773148 D 5061 CDS An13g03410 84592879 join(774572..774793,774898..775000,775124..775236) II 1 NT_166528.1 hypothetical protein 775236 84592879 An13g03410 Aspergillus niger hypothetical protein XP_059602175.1 774572 D 5061 CDS An13g03420 84592880 complement(join(775611..775725,775776..775834,776241..776451,776499..777050,777154..777368)) II 1 NT_166528.1 hypothetical protein 777368 84592880 An13g03420 Aspergillus niger hypothetical protein XP_059602176.1 775611 R 5061 CDS An13g03430 4986792 join(778654..779179,779235..779580,779633..779846) II 1 NT_166528.1 Title: similarity to hypothetical protein encoded by An15g04190 - Aspergillus niger; uncharacterized protein 779846 4986792 An13g03430 Aspergillus niger uncharacterized protein XP_001396478.1 778654 D 5061 CDS An13g03440 4986793 complement(join(780425..781460,781511..781653)) II 1 NT_166528.1 Title: similarity to hypothetical protein NMA2036 -Neisseria meningitidis; uncharacterized protein 781653 4986793 An13g03440 Aspergillus niger uncharacterized protein XP_001396479.3 780425 R 5061 CDS An13g03450 4986794 complement(join(783028..783454,783514..783902,783958..784065,784123..784137)) II 1 NT_166528.1 Title: weak similarity to integral membrane protein PTH11 from patent WO9913094-A2 - Magnaporthe grisea; uncharacterized protein 784137 4986794 An13g03450 Aspergillus niger uncharacterized protein XP_001396480.3 783028 R 5061 CDS An13g03460 84592881 complement(join(784711..784756,784851..784968,785057..785263,785353..785404)) II 1 NT_166528.1 hypothetical protein 785404 84592881 An13g03460 Aspergillus niger hypothetical protein XP_059602177.1 784711 R 5061 CDS An13g03470 4986796 join(785549..785558,785624..786012,786104..786321,786375..786523,786594..786928,786983..787846) II 1 NT_166528.1 Remark: similarity to bacterial Flavin monooxygenase fccC amino acid sequence SEQ ID NO:7. patent WO200004158-A2.; Remark: the prdicted ORF seems N-terminal approximately 150 aa to long.; Title: similarity to flavin monooxygenase fccC from patent WO200004158-A2 - Bacterium 2412.1; uncharacterized protein 787846 4986796 An13g03470 Aspergillus niger uncharacterized protein XP_059602178.1 785549 D 5061 CDS An13g03480 4986797 complement(join(788893..788954,789020..789220,789321..789405,789445..789510,789568..789582,789935..790431,790513..790750,790928..791203)) II 1 NT_166528.1 Remark: all found homolog proteins differ in size.; Title: weak similarity to tonoplast intrinsic protein ZmTIP1 - Zea mays; uncharacterized protein 791203 4986797 An13g03480 Aspergillus niger uncharacterized protein XP_059602179.1 788893 R 5061 CDS An13g03490 4986798 join(791524..791586,791636..791904,791991..792285) II 1 NT_166528.1 Remark: the 1. 8 A crystal structure of E. coli ycaCgp reveals an octameric complex comprised of two tetrameric rings. A large three-layer (alphabetaalpha) sandwich domain and a small helical domain form the folded structure of the monomeric unit. Comparisons with sequence and structure databases suggest that ycaCgp belongs to a diverse family of bacterial hydrolases. The most closely related three-dimensional structure is that of the D2 tetrameric N-carbamoylsarcosine amidohydrolase (CSHase) from an Arthrobacter species.; Title: strong similarity to hydrolase of unknown specificity ycaC - Escherichia coli; See PMID 9782055; uncharacterized protein 792285 4986798 An13g03490 Aspergillus niger uncharacterized protein XP_001396484.1 791524 D 5061 CDS An13g03500 4986799 join(792690..793496,793556..793645,793735..793749) II 1 NT_166528.1 Remark: human ARSDR1 is involved in the androgen receptor-regulated gene network of the human prostate that may play a role in the pathogenesis of prostate carcinoma.; Remark: the patent sequence is nearly the same as the human androgen-regulated short-chain dehydrogenase/reductase 1 except the 4 N-terminal amino acids.; Similarity: belongs to the short-chain alcohol dehydrogenases.; Title: strong similarity to sequence 1 from patent WO0065067-A - Homo sapiens; See PMID 11245473; uncharacterized protein 793749 4986799 An13g03500 Aspergillus niger uncharacterized protein XP_059602180.1 792690 D 5061 CDS An13g03510 84592882 complement(join(794819..794910,795018..795131,795221..795398)) II 1 NT_166528.1 Remark: the predicted ORF could encode, together with ORF 110CG, another part of the Ant1 transposon (lenght: 4918 nt), as the sequence 3' to this region is probably the transposase, which is decribed to lie 3' of the Ant1 transposon 5' insertion site (niaD insertion site).; hypothetical protein 795398 84592882 An13g03510 Aspergillus niger hypothetical protein XP_059602181.1 794819 R 5061 CDS An13g03520 4986801 795567..796955 II 1 NT_166528.1 Remark: the predicted ORF could encode, together with ORF 118WK, another part of the Ant1 transposon (lenght: 4918 nt), as the sequence 3' to this region is probably the transposase, which is decribed to lie 3' of the Ant1 transposon 5' insertion site (niaD insertion site).; Title: strong similarity to hypothetical protein encoded by An05g02110 - Aspergillus niger; uncharacterized protein 796955 4986801 An13g03520 Aspergillus niger uncharacterized protein XP_001396487.1 795567 D 5061 CDS An13g03530 4986802 complement(797021..798001) II 1 NT_166528.1 Function: ORF1 of transposon Ant1 from A. niger encodes a putative Tc1-mariner class transposase.; Title: strong similarity to protein encoded by ORF1 of transposon Ant1 - Aspergillus niger; See PMID 8552048; uncharacterized protein 798001 4986802 An13g03530 Aspergillus niger uncharacterized protein XP_001396488.1 797021 R 5061 CDS An13g03540 84592883 join(798632..799150,799198..799355,799442..799599,799925..800331) II 1 NT_166528.1 Title: similarity to hypothetical protein encoded by An04g03850 - Aspergillus niger; uncharacterized protein 800331 84592883 An13g03540 Aspergillus niger uncharacterized protein XP_059602182.1 798632 D 5061 CDS An13g03550 84592884 join(801118..801183,801240..801428,801642..802529) II 1 NT_166528.1 Function: co-expression of het-e and het-c lead to cell death.; Function: het-e1 of P. anserina is responsible for vegetative incompatibility.; Remark: due to the presence of WD-40 repeats, the ORF shows similarity to several proteins, that contain this motif.; Remark: het-e1 of P. anserina shows also two sequence motifs, a GTP-binding domain and a repeated region that shares similarity with that of the beta-transducin.; Remark: the reactivity of the HET-E protein depends on two functional elements, a GTP-binding domain and several WD40 repeats.; Similarity: the ORF is much shorter than het-e-1 of P. anserina (380 amino acids compaired to 1356), and shows no similarity to the GTP-binding domain of the vegetative incompatibility protein.; Title: strong similarity to vegetative incompatibility protein het-e1 - Podospora anserina; See PMID 10875280; See PMID 10974123; See PMID 7557402; See PMID 9435787; uncharacterized protein 802529 84592884 An13g03550 Aspergillus niger uncharacterized protein XP_059602183.1 801118 D 5061 CDS An13g03560 4986805 complement(join(803259..804004,804056..804362,804413..804754)) II 1 NT_166528.1 Function: MAOB of H. sapiens plays an important role in regulating the intracellular levels of amines via there oxidation, e. g. it catalyzes the oxidative deamination of many neuro-transmitters and dietary amines.; Title: strong similarity to flavin-containing amine oxidase MAOB - Homo sapiens; uncharacterized protein 804754 4986805 An13g03560 Aspergillus niger uncharacterized protein XP_001396491.1 803259 R 5061 CDS An13g03570 4986806 complement(join(805234..805693,805755..806218,806275..807207,807263..807632,807687..808282,808329..808572,808624..808967,809021..809472,809546..809628,809685..810172)) II 1 NT_166528.1 Similarity: the ORF shows strong similarity to ABC transporters/multidrug resistance proteins with various substrate specificities.; Title: strong similarity to ABC transporter CDR4 -Candida albicans; See PMID 9767132; uncharacterized protein 810172 4986806 An13g03570 Aspergillus niger uncharacterized protein XP_001396492.1 805234 R 5061 CDS An13g03580 84592885 join(810208..810331,810460..810512,810627..810836,810911..811063,811181..811312) II 1 NT_166528.1 hypothetical protein 811312 84592885 An13g03580 Aspergillus niger hypothetical protein XP_059602184.1 810208 D 5061 CDS An13g03590 4986808 join(811331..811909,812030..812215,812277..812749,812952..813390) II 1 NT_166528.1 Similarity: the ORF shows similarity to several putative transcrption regulators.; Title: similarity to fungal ZBC protein sequence #41 from patent WO200224865-A2 - unidentified organism; uncharacterized protein 813390 4986808 An13g03590 Aspergillus niger uncharacterized protein XP_059602185.1 811331 D 5061 CDS An13g03600 4986809 814824..816506 II 1 NT_166528.1 Catalytic activity: PLCN of B. pseudomallei converts phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate.; Function: PLCN of B. pseudomallei hydrolyses phosphatidylserine and phosphatidylcholine.; Similarity: the ORF overlaps with A. niger EST (EMBLEST:BE758821) an_3066.; Similarity: the predicted ORF is 225 amino acids shorter at its C-terminus than PLCN of B. pseudomallei.; Title: strong similarity to phosphatidylcholine-hydrolyzing phospholipase C PLCN -Burkholderia pseudomallei; uncharacterized protein 816506 4986809 An13g03600 Aspergillus niger uncharacterized protein XP_001396495.3 814824 D 5061 CDS An13g03610 4986810 complement(816783..818576) II 1 NT_166528.1 Function: FLU1 of C. albicans is a multidrug efflux transporter of the major facilitator superfamily, which confers resistance to fluconazole and to cycloheximide.; Phenotype: the disruption of FLU1 in C. albicans had only a slight effect on fluconazole susceptibility; however, it resulted in hypersusceptibility to mycophenolic acid, thus suggesting that this compound could be a substrate for the protein encoded by FLU1.; Similarity: the ORF shows strong similarity to various multidrug efflux transporters with different substrate specificities.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; uncharacterized protein 818576 4986810 An13g03610 Aspergillus niger uncharacterized protein XP_001396496.1 816783 R 5061 CDS An13g03620 4986811 complement(join(818781..819038,819183..819340,819748..820201)) II 1 NT_166528.1 hypothetical protein 820201 4986811 An13g03620 Aspergillus niger hypothetical protein XP_001396497.3 818781 R 5061 CDS An13g03630 84592886 complement(join(820374..820609,820696..820779,820886..820973,821048..821147,821226..821269,821371..821505)) II 1 NT_166528.1 hypothetical protein 821505 84592886 An13g03630 Aspergillus niger hypothetical protein XP_059602186.1 820374 R 5061 CDS An13g03640 4986813 join(821865..822049,822101..822122,822195..822244,822297..822626,822674..823577) II 1 NT_166528.1 Function: polyamine transport proteins in the vacuolar membrane regulate the polyamine content in the cytoplasm.; Similarity: the ORF is 97 amino acids shorter at the N-terminus than TPO1 of S. cerevisiae.; Title: strong similarity to polyamine transport protein Tpo1 - Saccharomyces cerevisiae; vacuole; See PMID 11171066; See PMID 9920864; See PMID 10585849; uncharacterized protein 823577 4986813 An13g03640 Aspergillus niger uncharacterized protein XP_059602187.1 821865 D 5061 CDS An13g03650 4986814 complement(join(824804..826278,826344..826566)) II 1 NT_166528.1 Function: high-affinity permease for lysine; Similarity: belongs to a family that groups many amino acid permeases; Title: strong similarity to lysine permease Lyp1 -Saccharomyces cerevisiae; plasma membrane; See PMID 8368011; uncharacterized protein 826566 4986814 An13g03650 Aspergillus niger uncharacterized protein XP_001396500.1 824804 R 5061 CDS An13g03660 4986815 complement(join(826580..826881,827091..827242,827375..827667,827899..827964,828130..828161,828226..828266,828320..828603,828637..828825)) II 1 NT_166528.1 Title: weak similarity to hypothetical protein encoded by An12g09260 - Aspergillus niger; uncharacterized protein 828825 4986815 An13g03660 Aspergillus niger uncharacterized protein XP_059602188.1 826580 R 5061 CDS An13g03670 84592887 830004..>830120 II 1 NT_166528.1 Remark: C-terminally truncated ORF due to contig end.; Title: questionable ORF [truncated ORF]; uncharacterized protein 830120 84592887 An13g03670 Aspergillus niger uncharacterized protein XP_059602189.1 830004 D 5061 CDS An13g03680 4986817 complement(join(830328..831273,831332..831954)) II 1 NT_166528.1 Induction: in S. cerevisiae the relatively high basal level of DAL5 expression did not increase further upon addition of allantoin pathway intermediates.; Repression: in S. cerevisiae steady-state DAL5 mRNA levels dropped precipitously when a repressive nitrogen source was provided.; Similarity: S. cerevisiae DAL5 specifies the Dal5p subfamily of the major facilitator family, which also includes YGR260w and YLR004c.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 10869563; See PMID 3275614; uncharacterized protein 831954 4986817 An13g03680 Aspergillus niger uncharacterized protein XP_001396503.1 830328 R 5061 CDS An13g03690 4986818 complement(join(832572..833865,834036..834091)) II 1 NT_166528.1 Title: strong similarity to hypothetical protein EAA59596.1 - Aspergillus nidulans; uncharacterized protein 834091 4986818 An13g03690 Aspergillus niger uncharacterized protein XP_059602190.1 832572 R 5061 CDS An13g03700 4986819 join(834501..834919,834971..835088,835140..835463) II 1 NT_166528.1 hypothetical protein 835463 4986819 An13g03700 Aspergillus niger hypothetical protein XP_059602191.1 834501 D 5061 CDS An13g03710 4986820 join(836313..836486,836533..836991,837095..838294) II 1 NT_166528.1 Catalytic activity: hydrolysis of terminal,non-reducing 1,4-linked alpha-D-glucose residues with release of alpha-D-glucose.; Pathway: galactose metabolism; starch and sucrose metabolism.; Remark: the substrate specificity of the SAM1606 alpha-glucosidase was significantly different from those of the oligo-1,6-glucosidases.; Similarity: belongs to the alpha-glucosidases.; Title: strong similarity to alpha-glucosidase aglU -Bacillus sp.; See PMID 8125087; uncharacterized protein 838294 4986820 An13g03710 Aspergillus niger uncharacterized protein XP_059602192.1 836313 D 5061 CDS An13g03730 10098176 join(838890..838993,839027..839285) II 1 NT_166528.1 Catalytic activity: acetyl-CoA + beta-D-Galactoside = CoA + 6-acetyl-beta-D-galactoside.; Remark: Escherichia coli galactoside acetyltransferase (GAT) is a member of a large family of acetyltransferases that O-acetylate dissimilar substrates but share limited sequence homology. Steady-state kinetic analysis of over-expressed GAT demonstrated that it accepted a range of substrates, including glucosides and lactosides which were acetylated at rates comparable to galactosides.; Remark: the ORF is C-terminal shorter than the matching sequences, probably due to an previous transposon insertion.; Similarity: belongs to the acetyltransferases (the isoleucine patch superfamily).; Title: similarity to galactoside acetyltransferase lacA - Escherichia coli; See PMID 7592843; uncharacterized protein 839285 10098176 An13g03730 Aspergillus niger uncharacterized protein XP_059602193.1 838890 D 5061 CDS An13g03740 84592888 complement(join(839694..840123,840186..840202,840444..840629)) II 1 NT_166528.1 Title: weak similarity to hypothetical retrovirus-related polyprotein - Arabidopsis thaliana; uncharacterized protein 840629 84592888 An13g03740 Aspergillus niger uncharacterized protein XP_059602194.1 839694 R 5061 CDS An13g03760 84592889 complement(join(842475..842551,842643..842703,842829..843050)) II 1 NT_166528.1 Title: similarity to hypothetical protein encoded by An02g09120 - Aspergillus niger; uncharacterized protein 843050 84592889 An13g03760 Aspergillus niger uncharacterized protein XP_059602195.1 842475 R 5061 CDS An13g03790 84592890 join(844025..844046,844146..844182,844299..844608) II 1 NT_166528.1 Remark: strong similarity to Candida albicans polypeptide sequence # 24 patent EP982401-A2.; Similarity: belongs to the acetyltransferases (the isoleucine patch superfamily).; Title: strong similarity to polypeptide sequence # 24 from patent EP982401-A2 - Candida albicans; uncharacterized protein 844608 84592890 An13g03790 Aspergillus niger uncharacterized protein XP_059602196.1 844025 D 5061 CDS An13g03800 4986826 complement(844930..846600) II 1 NT_166528.1 Remark: strong similarity to bacterial esterase (BEST1) WO9606175-A2 and WO9902703-A1.; Remark: the esterase enzyme can degrade fumonisin. The polynucleotides encoding fumonisin degrading enzymes are useful for degrading fumonisins during the process of harvesting grain for animal feed, or in plant tissues,which are used for silage or as a spray on grain, fruit or vegetables. They are also useful for detoxifying fumonisins, structurally related mycotoxins, and fumonisin hydrolysis products of both.; Title: strong similarity to fumonisin esterase BEST1 from patent WO9606175-A2 - Bacterium ATCC 55552; uncharacterized protein 846600 4986826 An13g03800 Aspergillus niger uncharacterized protein XP_001396512.1 844930 R 5061 CDS An13g03810 4986827 847624..849378 II 1 NT_166528.1 Catalytic activity: digallate + H2O = 2 gallate.; Remark: also hydrolyses ester links in other tannins.; Remark: strong similarity to Aspergillus oryzae tannase protein patent JP08080196-A.; Remark: tannase gene product is translated as a single polypeptide that is cleaved by post-translational modification into two tannase subunits linked by a disulfide bond(s).; Remark: tannins have a wide range of effects on various organisms - from toxic effects on animals to growth inhibition of microorganisms.; Remark: the tannase can be used for clarification in beer production.; Title: strong similarity to precursor of tannase -Aspergillus oryzae; See PMID 8917102; See PMID 10192896; See PMID 11191769; uncharacterized protein 849378 4986827 An13g03810 Aspergillus niger uncharacterized protein XP_001396513.1 847624 D 5061 CDS An13g03820 4986828 join(850948..851524,851578..851618,851673..852472,852768..852790,852878..852956,853001..853244,853314..853457) II 1 NT_166528.1 Remark: the CZF1 gene, encoding a putative transcription factor, was shown to be involved in the regulation of hyphal growth under certain conditions,including embedded conditions. Ectopic expression of CZF1 in embedded cells promoted the rapid formation of hyphae. Elimination of CZF1 and CPH1, encoding a homologue of the S. cerevisiae Ste12p transcription factor, led to a pronounced defect in filamentous growth of embedded cells.; Similarity: contains a Zn(2)-Cys(6), fungal-type binuclear cluster domain.; Title: similarity to zinc-finger protein CZF1 -Candida albicans; See PMID 10564506; See PMID 1409649; uncharacterized protein 853457 4986828 An13g03820 Aspergillus niger uncharacterized protein XP_059602197.1 850948 D 5061 CDS An13g03840 84592891 join(856073..856159,856380..856480,856535..856781) II 1 NT_166528.1 hypothetical protein 856781 84592891 An13g03840 Aspergillus niger hypothetical protein XP_059602198.1 856073 D 5061 CDS An13g03850 84592892 complement(join(856937..857275,857395..857439)) II 1 NT_166528.1 hypothetical protein 857439 84592892 An13g03850 Aspergillus niger hypothetical protein XP_059602199.1 856937 R 5061 CDS An13g03860 4986832 complement(join(858708..859882,859942..860098)) II 1 NT_166528.1 Title: strong similarity to hypothetical protein encoded by An08g09040 - Aspergillus niger; uncharacterized protein 860098 4986832 An13g03860 Aspergillus niger uncharacterized protein XP_001396517.1 858708 R 5061 CDS An13g03870 4986833 complement(join(860782..861841,861889..862493,862664..863075,863162..863244)) II 1 NT_166528.1 Remark: genetic analysis and GFP fusions show that the NLS of a Zn-binuclear cluster transcriptional activator of Aspergillus nidulans (PrnA) is tripartite.; Remark: the prnA gene A. nidulans codes for a transcriptional activator that mediates proline induction of four other genes involved in proline utilization as a nitrogen and/or carbon source in Aspergillus nidulans.; Similarity: belongs to unassigned GAL4-type zinc cluster proteins.; Title: strong similarity to transcription activator prnA - Aspergillus nidulans; nucleus; See PMID 9622360; See PMID 10788322; uncharacterized protein 863244 4986833 An13g03870 Aspergillus niger uncharacterized protein XP_059602200.1 860782 R 5061 CDS An13g03890 4986835 complement(join(864035..864388,864487..864840,864892..865293,865343..865357,865414..865596,865734..865853)) II 1 NT_166528.1 Similarity: to multidrug-efflux transporters.; Title: strong similarity to hypothetical protein B15I20.50 - Neurospora crassa; uncharacterized protein 865853 4986835 An13g03890 Aspergillus niger uncharacterized protein XP_001396519.3 864035 R 5061 CDS An13g03900 4986836 join(868158..868450,868511..868736,868795..868869,868967..868999) II 1 NT_166528.1 hypothetical protein 868999 4986836 An13g03900 Aspergillus niger hypothetical protein XP_001396520.3 868158 D 5061 CDS An13g03910 4986837 complement(join(870715..871234,871277..872217,872265..872312)) II 1 NT_166528.1 Function: PYD2 enables Saccharomyces kluyveri to degrade the majority of pyrimidines.; Induction: PYD2 expression is inducible by dihydrouracil, though not by uracil.; Similarity: PYD2 shows similarities with dihydroorotases, allantoinases and uricases from various organisms.; Title: strong similarity to dihydropyrimidinase Pyd2 - Saccharomyces kluyveri; See PMID 10656811; uncharacterized protein 872312 4986837 An13g03910 Aspergillus niger uncharacterized protein XP_059602201.1 870715 R 5061 CDS An13g03920 4986838 join(872645..873128,873174..874486) II 1 NT_166528.1 Remark: this enzyme has strict specificity for the D-form and strict substrate specificity for N-carbamyl-D-amino acids, but does not react with N-carbamyl-beta-alanine.; Title: similarity to N-carbamyl-D-amino acid amidohydrolase - Pseudomonas sp.; See PMID 9648218; uncharacterized protein 874486 4986838 An13g03920 Aspergillus niger uncharacterized protein XP_059602202.1 872645 D 5061 CDS An13g03930 4986839 complement(join(874557..875803,875845..875930,875990..876089,876133..876301)) II 1 NT_166528.1 Function: DAL4 is responsible for the transport of allantoin into the cell.; Phenotype: DAL4 mutants are unable to transport allantoin and exhibit a 50% loss of allantoate transport.; Similarity: there is a striking similarity of DAL4 to the uracil permease component encoded by FUR4.; Title: strong similarity to allantoin transport protein Dal4 - Saccharomyces cerevisiae; plasma membrane; See PMID 1293888; See PMID 3549700; uncharacterized protein 876301 4986839 An13g03930 Aspergillus niger uncharacterized protein XP_059602203.1 874557 R 5061 CDS An13g03940 4986840 complement(join(876738..877727,877772..877849,877925..878104)) II 1 NT_166528.1 Function: LCAD is involved in the utilization of fatty acids for energy generation.; Title: strong similarity to long-chain-acyl-CoA dehydrogenase precursor LCAD - Rattus norvegicus; localisation:mitochondrion; See PMID 8268228; See PMID 2777793; uncharacterized protein 878104 4986840 An13g03940 Aspergillus niger uncharacterized protein XP_059602204.1 876738 R 5061 CDS An13g03950 4986841 join(878972..879086,879137..879407,879491..880358) II 1 NT_166528.1 Title: strong similarity to hypothetical protein EAA59522.1 - Aspergillus nidulans; uncharacterized protein 880358 4986841 An13g03950 Aspergillus niger uncharacterized protein XP_001396525.1 878972 D 5061 CDS An13g03960 84592893 complement(join(880510..880667,880777..880911,880958..881045)) II 1 NT_166528.1 hypothetical protein 881045 84592893 An13g03960 Aspergillus niger hypothetical protein XP_059602205.1 880510 R 5061 CDS An13g03970 4986843 join(881243..881354,881414..882199,882248..882299,882357..882401,882451..882504,882616..882643) II 1 NT_166528.1 Catalytic activity: FAD of M. marinus catalyzes the reaction of formaldehyde + glutathione + NAD+ = S-formylglutathione + NADH.; Remark: the ORF encoded protein also shows similarity to other dehydrogenases.; Similarity: FAD of M. marinus belongs to the zinc-containing alcohol dehydrogenase family. class-III subfamily.; Title: similarity to glutathione-dependent formaldehyde dehydrogenase FDH - Methylobacter marinus; See PMID 7926692; uncharacterized protein 882643 4986843 An13g03970 Aspergillus niger uncharacterized protein XP_059602206.1 881243 D 5061 CDS An13g03980 4986844 complement(join(883184..883234,883290..883936,883987..884371)) II 1 NT_166528.1 Phenotype: disruption of flavanone 3 beta-hydroxylase in Petunia hybrida causes white flowers.; Remark: the ORF encoded protein also shows similarity to other oxidoreductase.; Similarity: 3 beta-hydroxylase of Petunia hybrida belongs to the 1-aminocyclopropane-1-carboxylate oxidase family.; Title: similarity to flavanone 3 beta-hydroxylase -Petunia hybrida; See PMID 1544919; See PMID 2154946; uncharacterized protein 884371 4986844 An13g03980 Aspergillus niger uncharacterized protein XP_001396528.1 883184 R 5061 CDS An13g03990 4986845 join(884738..885237,885285..885389,885438..885813,885870..886012,886069..886139,886190..886731) II 1 NT_166528.1 Function: FUI1 of S. cerevisiae is required for the high-affinity transport of uridine.; Remark: YBL042C and YBL040 are alternative names for FUI1 of S. cerevisiae.; Remark: the ORF encoded protein also shows strong similarity to allantoin permeases.; Similarity: FUI1 of S. cerevisiae belongs to the allantoin permease family.; Title: strong similarity to uridine permease Fui1 -Saccharomyces cerevisiae; plasma membrane; See PMID 9485596; uncharacterized protein 886731 4986845 An13g03990 Aspergillus niger uncharacterized protein XP_059602207.1 884738 D 5061 CDS An13g04000 4986846 complement(join(886968..887829,887906..888216)) II 1 NT_166528.1 Catalytic activity: hmgA of S. solfaticus catalyzes the reaction of (S)-mevalonate + CoA + 2 NADP+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.; Function: hmgA of S. solfaticus converts HMG-CoA to mevalonate.; Similarity: hmgA of S. solfaticus belongs to the HMG-CoA reductase family.; Title: strong similarity to hydroxymethylglutaryl-CoA reductase hmgA - Sulfolobus solfataricus; See PMID 9171410; uncharacterized protein 888216 4986846 An13g04000 Aspergillus niger uncharacterized protein XP_059602208.1 886968 R 5061 CDS An13g04010 84592894 join(889569..889923,889989..890266) II 1 NT_166528.1 Title: similarity to hypothetical protein encoded by An13g04050 - Aspergillus niger; uncharacterized protein 890266 84592894 An13g04010 Aspergillus niger uncharacterized protein XP_059602209.1 889569 D 5061 CDS An13g04030 4986849 complement(join(890943..891324,891515..891633,892308..892339,892433..893330,893384..893407)) II 1 NT_166528.1 Title: similarity to hypothetical protein B11A5.10 -Neurospora crassa; uncharacterized protein 893407 4986849 An13g04030 Aspergillus niger uncharacterized protein XP_001396533.3 890943 R 5061 CDS An13g04040 84592895 join(893780..894060,894109..894712) II 1 NT_166528.1 hypothetical protein 894712 84592895 An13g04040 Aspergillus niger hypothetical protein XP_059602210.1 893780 D 5061 CDS An13g04050 84592896 join(896196..896256,896309..896346,896407..896900,896983..897202) II 1 NT_166528.1 Title: similarity to hypothetical protein encoded by An13g04010 - Aspergillus niger; uncharacterized protein 897202 84592896 An13g04050 Aspergillus niger uncharacterized protein XP_059602211.1 896196 D 5061 CDS An13g04060 4986852 complement(join(901805..902537,902604..902719,902799..903118,903189..903858)) II 1 NT_166528.1 Title: strong similarity to hypothetical protein encoded by An07g08820 - Aspergillus niger; uncharacterized protein 903858 4986852 An13g04060 Aspergillus niger uncharacterized protein XP_001396536.1 901805 R 5061 CDS An13g04070 4986853 complement(join(904837..905931,905996..906067)) II 1 NT_166528.1 Title: strong similarity to FLO11 gene expression regulator At14 from patent WO200257456-A2 - Unclassified organism; uncharacterized protein 906067 4986853 An13g04070 Aspergillus niger uncharacterized protein XP_001396537.1 904837 R 5061 CDS An13g04080 4986854 join(906528..906872,907115..907205,907272..907850,907950..908314,908465..908626) II 1 NT_166528.1 Remark: this P450 of G. fujikuroi is, together with three similar P450 monooxygenases, a putative geranylgeranyl diphosphate synthase, and a copalyl diphosphate synthase, involved in gibberellin biosynthesis.; Title: strong similarity to cytochrome P450 monooxygenase P450II - Gibberella fujikuroi; See PMID 9917370; See PMID 10531641; uncharacterized protein 908626 4986854 An13g04080 Aspergillus niger uncharacterized protein XP_059602212.1 906528 D 5061 CDS An12g00010 4985368 complement(472..1230) III 1 NT_166527.1 Remark: questionable ORF due to the absence of an intron-exon structure.; Title: questionable ORF; uncharacterized protein 1230 4985368 An12g00010 Aspergillus niger uncharacterized protein XP_059601723.1 472 R 5061 CDS An12g00015 84592438 complement(2164..2562) III 1 NT_166527.1 hypothetical protein 2562 84592438 An12g00015 Aspergillus niger hypothetical protein XP_059601724.1 2164 R 5061 CDS An12g00020 4985367 complement(join(3315..3349,3399..3441,3566..3741,3803..5077,5157..5433)) III 1 NT_166527.1 Function: lactate dehydrogenases catalyse the oxidation of lactate to pyruvate.; Remark: the predicted ORF shows homology to A. nidulans EST AA966896.; Similarity: the predicted ORF shows similarity to some lactate dehydrogenases from several species.; Title: strong similarity to D-lactate dehydrogenase dld - Kluyveromyces lactis; uncharacterized protein 5433 4985367 An12g00020 Aspergillus niger uncharacterized protein XP_059601725.1 3315 R 5061 CDS An12g00030 4985352 join(6505..6531,6642..6764,6840..7766) III 1 NT_166527.1 Catalytic activity: L-iditol 2-dehydrogenases catalyze L-sorbitol + NAD(+) = L-sorbose + NADH.; Function: L-iditol 2-dehydrogenases catalyze the oxidation by NAD+ of sorbitol to fructose.; Remark: the predicted ORF shows partial similarity to A. nidulans ESTs AA785306 and AA966892.; Title: strong similarity to L-iditol 2-dehydrogenase Sor1 - Saccharomyces cerevisiae; See PMID 8125328; See PMID 9464424; uncharacterized protein 7766 4985352 An12g00030 Aspergillus niger uncharacterized protein XP_001395093.1 6505 D 5061 CDS An12g00040 4985385 complement(join(8470..8887,9041..9320,9442..9476,9555..9607)) III 1 NT_166527.1 Function: rab4 is involved in intracellular trafficking of proteins and might play a role in transport arrest during mitosis.; Remark: human rab4 is phoshorylated by cdc2-kinase during mitosis.; Title: strong similarity to GTP-binding protein rab4 - Homo sapiens; intracellular transport vesicles; See PMID 8330623; See PMID 1902553; See PMID 2501306; uncharacterized protein 9607 4985385 An12g00040 Aspergillus niger uncharacterized protein XP_059601726.1 8470 R 5061 CDS An12g00050 4985377 complement(join(10286..12808,12925..13020)) III 1 NT_166527.1 hypothetical protein 13020 4985377 An12g00050 Aspergillus niger hypothetical protein XP_059601727.1 10286 R 5061 CDS An12g00060 4985382 14270..15256 III 1 NT_166527.1 Title: similarity to hypothetical protein CAE76586.1 - Neurospora crassa; uncharacterized protein 15256 4985382 An12g00060 Aspergillus niger uncharacterized protein XP_001395096.1 14270 D 5061 CDS An12g00080 84592439 join(19319..19405,19470..19510,19545..19563,19601..19621) III 1 NT_166527.1 Remark: questionable ORF due to the presence of only 55 amino acids coding sequence.; Title: questionable ORF; uncharacterized protein 19621 84592439 An12g00080 Aspergillus niger uncharacterized protein XP_059601728.1 19319 D 5061 CDS An12g00090 84592440 join(20244..20289,20384..20436,20526..20674,20742..20844,20949..21008) III 1 NT_166527.1 hypothetical protein 21008 84592440 An12g00090 Aspergillus niger hypothetical protein XP_059601729.1 20244 D 5061 CDS An12g00100 4985381 join(24067..24104,24211..25080,25124..25357,25403..25694,26251..26323,26473..26510) III 1 NT_166527.1 Similarity: the N-terminal part of the predicted ORF shows weak similarities to polysaccharide synthesizing proteins of fungi and plants, that are supposed to be involved in cell wall biogenesis.; Similarity: the predicted ORF shows similarities to A. nidulans EST AA784284.; Title: strong similarity to hypothetical polysaccharide synthase CPS1 - Filobasidiella neoformans; uncharacterized protein 26510 4985381 An12g00100 Aspergillus niger uncharacterized protein XP_059601730.1 24067 D 5061 CDS An12g00110 4985373 join(27685..27982,28049..28845) III 1 NT_166527.1 Function: atp12 of S. cerevisiae is required for the assembly of the mitochondrial F1-F0 complex.; Localization: atp12 of S. cerevisiae is located in the mitochondrial matrix.; Similarity: the first 40 amino acids of atp12 from S. cerevisiae, which are probably necessary for mitochondrial localization, show no homology to the predicted ORF.; Title: strong similarity to F1-F0 complex assembling factor Atp12 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 1826907; See PMID 2142305; uncharacterized protein 28845 4985373 An12g00110 Aspergillus niger uncharacterized protein XP_001395100.1 27685 D 5061 CDS An12g00120 4985375 join(29221..29240,29487..30727,30791..32166,32231..32584,32656..33426) III 1 NT_166527.1 Function: swh1 of S. cerevisiae plays a role in ergosterol synthesis.; Function: the seven homologues of the mammalian oxysterol-binding protein (OSBP) in S. cerevisiae are implicated in lipid trafficking and sterol homeostasis.; Remark: swh1 is also called osh1 or YAR044W.; Similarity: the predicted ORF shares homologies with the A. nidulans EST AA788412.; Title: strong similarity to hypothetical oxysterol binding protein homologue Swh1 - Saccharomyces cerevisiae; See PMID 11238399; uncharacterized protein 33426 4985375 An12g00120 Aspergillus niger uncharacterized protein XP_059601731.1 29221 D 5061 CDS An12g00130 4985387 join(33667..34555,34621..35306) III 1 NT_166527.1 Function: the mss51 protein of S. cerevisiae is required for the maturation and translation of cytochrome c oxidase subunit I mRNA.; Phenotype: the mss51 mutant of S. cerevisiae is respiratory deficient due to the absence of cytochrome c oxidase subunit 1 (Cox1p).; Similarity: the predicted ORF is identical to the first 42 nucleotides of A. niger EST ANI239933.; Title: strong similarity to mRNA processing protein of cytochrome c oxidase Mss51 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 6320175; See PMID 10803883; See PMID 2177521; See PMID 6297789; uncharacterized protein 35306 4985387 An12g00130 Aspergillus niger uncharacterized protein XP_001395102.1 33667 D 5061 CDS An12g00140 84592441 complement(36341..36880) III 1 NT_166527.1 Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: weak similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942; uncharacterized protein 36880 84592441 An12g00140 Aspergillus niger uncharacterized protein XP_059601732.1 36341 R 5061 CDS An12g00150 84592442 join(37999..38051,38218..38306,38535..38722) III 1 NT_166527.1 Remark: questionable ORF due to the presence of unusally long introns.; Title: questionable ORF; uncharacterized protein 38722 84592442 An12g00150 Aspergillus niger uncharacterized protein XP_059601733.1 37999 D 5061 CDS An12g00160 4985372 complement(join(39797..40134,40207..40574,40645..40911,40979..41112,41162..41290,41343..41546,41619..41840,41893..42060)) III 1 NT_166527.1 Catalytic activity: mae1 of S. cerevisiae (oxaloacetate decarboxylating) catalyses the oxidative decarboxylation of malate to pyruvate (S)-malate + NAD(+) <=> pyruvate + CO2 + NADH.; Function: mae1 of S. cerevisiae is involved in the synthesis of pyruvate by facilitating an alternative route for pyruvate synthesis, that is not dependent on the activity of pyruvate kinase.; Induction: a three to fourfold induction of mae1 from S. cerevisiae was observed during anaerobic growth on glucose.; Phenotype: the null mutant of S. cerevisiae exhibits no malic enzyme activity.; Title: strong similarity to malate dehydrogenase homolog Mae1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9062925; See PMID 9603875; uncharacterized protein 42060 4985372 An12g00160 Aspergillus niger uncharacterized protein XP_001395105.3 39797 R 5061 CDS An12g00170 4985376 complement(join(43434..44441,44521..44553)) III 1 NT_166527.1 Catalytic activity: quinone reductases catalyse NADPH + quinone = NADP(+) + semiquinone.; Function: quinone reductases catalyse the one electron reduction of certain quinones.; Title: strong similarity to quinone reductase cryz -Cavia porcellus; See PMID 9426193; See PMID 1989495; uncharacterized protein 44553 4985376 An12g00170 Aspergillus niger uncharacterized protein XP_001395106.1 43434 R 5061 CDS An12g00180 4985356 complement(join(45427..46390,46457..46584)) III 1 NT_166527.1 hypothetical protein 46584 4985356 An12g00180 Aspergillus niger hypothetical protein XP_001395107.1 45427 R 5061 CDS An12g00190 84592443 complement(join(47480..47803,48875..49049,49113..49206,49325..49442,49810..49906,49962..50041,50169..50233,50319..50410,50914..51068,51167..51273,51354..51400,51571..51650,51707..51785,51938..52039,52172..52217,52298..52370)) III 1 NT_166527.1 Remark: questionable ORF due to unusal exon-intron structure.; Title: questionable ORF; uncharacterized protein 52370 84592443 An12g00190 Aspergillus niger uncharacterized protein XP_059601734.1 47480 R 5061 CDS An12g00200 84592444 join(52373..52403,52592..52705,52871..53106,53183..53333,53454..53713,53801..53977,54016..54304,54400..54458,54514..54633,54734..54846,55290..55367,55465..55708) III 1 NT_166527.1 Remark: questionable ORF due to the presence of an unusal exon-intro structure.; Title: questionable ORF; uncharacterized protein 55708 84592444 An12g00200 Aspergillus niger uncharacterized protein XP_059601735.1 52373 D 5061 CDS An12g00210 4985365 complement(56392..61527) III 1 NT_166527.1 Function: snf2 of H. sapiens as part of the swi/snf complex is involved in reorganization of chromatin structure to facilitate binding of transcription factors.; Function: the human swi/snf complex mediates the ATP-dependent disruption of a nucleosome, thereby enabling the activators, gal4-vp16 and gal4-ah, to bind within a nucleosome core.; Remark: the predicted ORF is 100 amino acids longer at the N-terminus than human snf2.; Similarity: the predicted ORF shows similarities with several snf proteins from different species starting around amino acid 800 of the predicted ORF.; Title: strong similarity to transcription activator snf2 - Homo sapiens; nucleus; See PMID 8047169; See PMID 9099865; uncharacterized protein 61527 4985365 An12g00210 Aspergillus niger uncharacterized protein XP_001395110.1 56392 R 5061 CDS An12g00220 4985358 join(62137..62259,62332..62643,62706..62735) III 1 NT_166527.1 Similarity: the predicted ORF overlaps with A. niger EST BE759492.; Similarity: the predicted ORF shares weak similarities with one chain of human and bovine NADH dehydrogenase.; Title: strong similarity to hypothetical protein EAA61911.1 - Aspergillus nidulans; uncharacterized protein 62735 4985358 An12g00220 Aspergillus niger uncharacterized protein XP_001395111.1 62137 D 5061 CDS An12g00230 4985374 join(63687..65623,65678..65863,65921..66389,66441..67025,67083..67976) III 1 NT_166527.1 Title: strong similarity to hypothetical protein B14D6.520 - Neurospora crassa; uncharacterized protein 67976 4985374 An12g00230 Aspergillus niger uncharacterized protein XP_001395112.1 63687 D 5061 CDS An12g00240 4985362 complement(join(68429..68575,68664..>68804)) III 1 NT_166527.1 Function: a member of the yer057c/yjgf/upf0076/uk114 family, the yabJ gene from B. subtilis is required for adenine-mediated repression of purine biosynthetic genes.; Function: human recombinant uk14 (p14. 5) inhibits in vitro protein synthesis in a rabbit reticulocyte lysate system.; Induction: the uk14 mRNA of H. sapiens is weakly expressed in freshly isolated monocytes, but is significantly upregulated when these monocytes are subjected to differentiation.; Remark: the ORF is N-terminally truncated due to 3' contig boder.; Remark: uk14 belongs to the new hypothetical family of small proteins with presently unknown function, named yer057c/yjgf/upf0076/uk114 family.; Title: strong similarity to translational inhibitor uk14 - Homo sapiens [truncated ORF]; See PMID 8973653; uncharacterized protein 68804 4985362 An12g00240 Aspergillus niger uncharacterized protein XP_001395113.3 68429 R 5061 CDS An12g00250 84592445 join(<68907..68990,69044..69115,69164..69265) III 1 NT_166527.1 Remark: the ORF encoded protein is N-terminally truncated due to the contig border.; Title: weak similarity to precursor of antiplatelet protein - Haementeria officinalis [truncated ORF]; uncharacterized protein 69265 84592445 An12g00250 Aspergillus niger uncharacterized protein XP_059601736.1 68907 D 5061 CDS An12g00260 4985366 complement(join(69621..71030,71232..71354)) III 1 NT_166527.1 Remark: blastp homologies may be due to repetetive sequence motives.; Title: weak similarity to hypothetical protein AAF50995.2 - Drosophila melanogaster; uncharacterized protein 71354 4985366 An12g00260 Aspergillus niger uncharacterized protein XP_059601737.1 69621 R 5061 CDS An12g00270 84592446 join(71572..71681,71778..72117) III 1 NT_166527.1 hypothetical protein 72117 84592446 An12g00270 Aspergillus niger hypothetical protein XP_059601738.1 71572 D 5061 CDS An12g00290 84592447 join(72966..72968,73099..73341,73478..73546) III 1 NT_166527.1 hypothetical protein 73546 84592447 An12g00290 Aspergillus niger hypothetical protein XP_059601739.1 72966 D 5061 CDS An12g00300 84592448 complement(73805..74002) III 1 NT_166527.1 hypothetical protein 74002 84592448 An12g00300 Aspergillus niger hypothetical protein XP_059601740.1 73805 R 5061 CDS An12g00310 84592449 join(74451..74519,74630..74710,74793..74891,75133..75223,75295..75382,75464..75578) III 1 NT_166527.1 hypothetical protein 75578 84592449 An12g00310 Aspergillus niger hypothetical protein XP_059601741.1 74451 D 5061 CDS An12g00320 4985360 join(76298..76796,76877..77031) III 1 NT_166527.1 Catalytic activity: APT1 of S. cerevisiae catalyzes the reaction of AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.; Pathway: APT1 of S. cerevisiae play a role in the purin salvage pathway.; Remark: YML022W is the systematic name for APT1.; Title: strong similarity to adenine phosphoribosyltransferase Apt1 - Saccharomyces cerevisiae; See PMID 7642142; uncharacterized protein 77031 4985360 An12g00320 Aspergillus niger uncharacterized protein XP_001395120.1 76298 D 5061 CDS An12g00330 4985359 complement(join(77461..77494,77616..78286)) III 1 NT_166527.1 Title: weak similarity to hypothetical protein Rv0923c - Mycobacterium tuberculosis; uncharacterized protein 78286 4985359 An12g00330 Aspergillus niger uncharacterized protein XP_001395121.3 77461 R 5061 CDS An12g00340 4985369 complement(join(79220..81292,81386..81433,81488..81668,81759..81919,82025..82053,82111..82172,82215..82481,82559..82635)) III 1 NT_166527.1 Function: human alpha 1,2-mannosidase IB processes Man9GlcNAc to Man5GlcNAc.; Title: similarity to alpha 1,2-mannosidase IB - Homo sapiens; See PMID 9592125; uncharacterized protein 82635 4985369 An12g00340 Aspergillus niger uncharacterized protein XP_059601742.1 79220 R 5061 CDS An12g00350 4985361 complement(join(83407..83616,83684..84535)) III 1 NT_166527.1 hypothetical protein 84535 4985361 An12g00350 Aspergillus niger hypothetical protein XP_001395123.3 83407 R 5061 CDS An12g00360 84592450 join(84561..84577,84639..84879,84899..84979) III 1 NT_166527.1 hypothetical protein 84979 84592450 An12g00360 Aspergillus niger hypothetical protein XP_059601743.1 84561 D 5061 CDS An12g00370 4985364 complement(join(86711..86763,86819..87574,87639..87719,87825..88038)) III 1 NT_166527.1 Function: the human small nuclear ribonucleoprotein (snRNP) U5 is part of the spliceosome.; Title: strong similarity to U5 snRNP-specific 40 kDa protein - Homo sapiens; See PMID 9774689; uncharacterized protein 88038 4985364 An12g00370 Aspergillus niger uncharacterized protein XP_059601744.1 86711 R 5061 CDS An12g00380 4985384 join(88424..88461,88636..88855,88937..89128,89210..89329) III 1 NT_166527.1 Complex: Bet3p is a component of the TRAPP complex which may act upstream of the SNARE complex.; Function: Bet3p of S. cerevisiae is nvolved in targeting and fusion of ER to golgi transport vesicles.; Golgi; Phenotype: bet3-1 at the nonpermissive temperature fails to transport invertase, alpha-factor and carboxypeptidase Y to the Golgi.; Remark: YKR068C is the systematic name for BET3.; Title: strong similarity to Bet3 - Saccharomyces cerevisiae; See PMID 10698928; uncharacterized protein 89329 4985384 An12g00380 Aspergillus niger uncharacterized protein XP_059601745.1 88424 D 5061 CDS An12g00390 4985388 join(92116..92613,92670..92821,92905..94189,94255..94518,94577..94747) III 1 NT_166527.1 Title: strong similarity to hypothetical protein SOM1 - Neurospora crassa; uncharacterized protein 94747 4985388 An12g00390 Aspergillus niger uncharacterized protein XP_059601746.1 92116 D 5061 CDS An12g00400 4985389 complement(join(97834..99035,99184..99227,99294..99528,99598..99694)) III 1 NT_166527.1 Title: weak similarity to hypothetical protein K06A9.1a - Caenorhabditis elegans; uncharacterized protein 99694 4985389 An12g00400 Aspergillus niger uncharacterized protein XP_059601747.1 97834 R 5061 CDS An12g00410 4985390 complement(join(101316..102069,102130..102273,102330..102434,102497..102702)) III 1 NT_166527.1 Localization: RBP47 of N. plumbaginifolia is localized in the nucleus.; Remark: RBP47 of N. plumbaginifolia does not stimulate mRNA splicing.; Remark: in vivo UV crosslinking experiments demonstrated that RBP47 of N. plumbaginifolia is associated with the nuclear poly(A)+ RNA.; Title: strong similarity to RNA binding protein 47 RBP47 - Nicotiana plumbaginifolia; nucleus; See PMID 11105760; uncharacterized protein 102702 4985390 An12g00410 Aspergillus niger uncharacterized protein XP_059601748.1 101316 R 5061 CDS An12g00420 84592451 complement(join(104857..104964,105141..105233,105523..105913,106261..106496)) III 1 NT_166527.1 hypothetical protein 106496 84592451 An12g00420 Aspergillus niger hypothetical protein XP_059601749.1 104857 R 5061 CDS An12g00430 84592452 complement(join(107669..107735,107919..108087,108125..108180,108219..108274,108399..108650)) III 1 NT_166527.1 hypothetical protein 108650 84592452 An12g00430 Aspergillus niger hypothetical protein XP_059601750.1 107669 R 5061 CDS An12g00440 4985393 complement(join(109436..109956,110032..110440)) III 1 NT_166527.1 Title: weak similarity to hypothetical protein SPCC1494.09c - Schizosaccharomyces pombe; uncharacterized protein 110440 4985393 An12g00440 Aspergillus niger uncharacterized protein XP_001395132.1 109436 R 5061 CDS An12g00450 4985394 complement(join(111221..111247,111290..112201)) III 1 NT_166527.1 Title: similarity to hypothetical protein bK126B4.3 - Homo sapiens; uncharacterized protein 112201 4985394 An12g00450 Aspergillus niger uncharacterized protein XP_059601751.1 111221 R 5061 CDS An12g00460 4985395 complement(join(112576..112643,112692..112854,112907..112929,112993..113420,113485..113588,113659..113754,113880..113963,114057..114095)) III 1 NT_166527.1 Function: C. albicans DLH1 complements a dmc1/dmc1 null mutant in S. cerevisiae. DLH1 restores both sporulation and meiotic recombination to a Saccharomyces dmc1 delta/dmc1 delta strain.; Remark: C. albicans is a fungus that is thought not to undergo meiosis, yet the presence of an intact homologue of a meiosis-specific gene in C. albicans raises the possibility that this organism has a cryptic meiotic pathway.; Similarity: the predicted A. niger protein shows strong similarity to the functional homologue of the meiosis-specific gene DMC1 (DLH1) of C. albicans.; Title: strong similarity to protein DLH1 - Candida albicans; See PMID 8725225; uncharacterized protein 114095 4985395 An12g00460 Aspergillus niger uncharacterized protein XP_059601752.1 112576 R 5061 CDS An12g00470 4985396 complement(join(115058..115297,115357..115542,115608..115723,115885..115896,115969..116004,116071..116125)) III 1 NT_166527.1 Title: similarity to hexamer-binding protein HEXBP -Leishmania major; See PMID 8314766; uncharacterized protein 116125 4985396 An12g00470 Aspergillus niger uncharacterized protein XP_059601753.1 115058 R 5061 CDS An12g00480 4985397 complement(join(117646..117717,117801..118535,118593..119309)) III 1 NT_166527.1 Catalytic activity: UTP + N-acetyl-alpha-D-glucosamine 1-phosphate <=> diphosphate + UDP-N-acetyl-D-glucosamine; Title: strong similarity to UDP-N-acetylglucosamine pyrophosphorylase CaUAP1 - Candida albicans; See PMID 9603950; uncharacterized protein 119309 4985397 An12g00480 Aspergillus niger uncharacterized protein XP_001395136.1 117646 R 5061 CDS An12g00490 4985398 complement(join(120078..120494,120553..120749,120803..121503,121617..121696)) III 1 NT_166527.1 Catalytic activity: Peptidylproline (omega=180) <=> peptidylproline (omega=0); Remark: Cis-trans isomerization of proline imidic peptide bonds in oligopeptides.; Title: strong similarity to cyclophilin isoform 10 cyp-10 - Caenorhabditis elegans; See PMID 8694762; uncharacterized protein 121696 4985398 An12g00490 Aspergillus niger uncharacterized protein XP_001395137.1 120078 R 5061 CDS An12g00500 4985399 join(125356..125583,125630..125740,125816..126943) III 1 NT_166527.1 Title: weak similarity to hypothetical protein CG7709 - Drosophila melanogaster; uncharacterized protein 126943 4985399 An12g00500 Aspergillus niger uncharacterized protein XP_059601754.1 125356 D 5061 CDS An12g00510 4985400 complement(join(129181..129257,129329..129576,129856..129932)) III 1 NT_166527.1 Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S24.e - Saccharomyces cerevisiae; cytoplasm; 40S ribosomal protein eS24 129932 4985400 An12g00510 Aspergillus niger 40S ribosomal protein eS24 XP_001395139.1 129181 R 5061 CDS An12g00520 4985401 join(130334..130570,130704..131297,131627..131795,131876..131991) III 1 NT_166527.1 Title: similarity to hypothetical membrane protein YJR129c - Saccharomyces cerevisiae; uncharacterized protein 131991 4985401 An12g00520 Aspergillus niger uncharacterized protein XP_059601755.1 130334 D 5061 CDS An12g00530 4985402 complement(132389..134467) III 1 NT_166527.1 Title: similarity to myosin heavy chain - Gallus gallus; uncharacterized protein 134467 4985402 An12g00530 Aspergillus niger uncharacterized protein XP_059601756.1 132389 R 5061 CDS An12g00540 84592453 join(134614..134797,134852..135075) III 1 NT_166527.1 hypothetical protein 135075 84592453 An12g00540 Aspergillus niger hypothetical protein XP_059601757.1 134614 D 5061 CDS An12g00550 4985404 complement(join(135616..135845,136041..136359,136624..136730,136788..137303,137362..137608,137671..137801,137862..138088,138148..139061)) III 1 NT_166527.1 Title: strong similarity to hypothetical protein KIAA1464 - Homo sapiens; uncharacterized protein 139061 4985404 An12g00550 Aspergillus niger uncharacterized protein XP_001395143.3 135616 R 5061 CDS An12g00560 84592454 join(140100..140139,140177..140276,140344..140441,140613..140809) III 1 NT_166527.1 hypothetical protein 140809 84592454 An12g00560 Aspergillus niger hypothetical protein XP_059601758.1 140100 D 5061 CDS An12g00570 4985406 complement(join(141115..141499,141556..141977)) III 1 NT_166527.1 Title: similarity to hypothetical protein SPAC23G3.04 - Schizosaccharomyces pombe; uncharacterized protein 141977 4985406 An12g00570 Aspergillus niger uncharacterized protein XP_001395145.1 141115 R 5061 CDS An12g00580 4985407 complement(join(144377..144883,144925..144948,144981..145499,145589..145633)) III 1 NT_166527.1 Remark: DnaJ protein could behave as a functional heat shock protein in Brucella ovis.; Title: weak similarity to heat shock protein dnaJ -Brucella ovis; See PMID 1459952; uncharacterized protein 145633 4985407 An12g00580 Aspergillus niger uncharacterized protein XP_059601759.1 144377 R 5061 CDS An12g00590 4985408 join(145959..147279,147437..147579) III 1 NT_166527.1 Remark: YOR340c is the alternate name for RPA43.; Similarity: the similarity to S. cerevisiae RPA43 is concerning the N-terminal half of the predicted ORF.; Title: similarity to 36 kD subunit of DNA-dependent RNA polymerase I Rpa43 - Saccharomyces cerevisiae; See PMID 7592632; uncharacterized protein 147579 4985408 An12g00590 Aspergillus niger uncharacterized protein XP_001395147.3 145959 D 5061 CDS An12g00600 4985409 complement(join(147812..149069,149124..149313,149388..149610)) III 1 NT_166527.1 Catalytic activity: NADH + 2 monodehydroascorbate = NAD(+) + 2 ascorbate.; Remark: MDA reductase from Cucumis sativus, an FAD-enzyme, is the first enzyme to be identified whose substrate is an organic radical and catalyzes the reduction of MDA to ascorbate by NAD(P)H.; Title: similarity to monodehydroascorbate reductase MDA - Cucumis sativus; See PMID 7545669; uncharacterized protein 149610 4985409 An12g00600 Aspergillus niger uncharacterized protein XP_001395148.3 147812 R 5061 CDS An12g00610 4985410 complement(join(150602..151607,151664..153982,154069..154430)) III 1 NT_166527.1 Remark: serine rich proteins.; Remark: shows also similarities to dentin sialophosphoprotein precursor of Homo sapiens.; Title: weak similarity to RNA I and III supressor gene Srp40 - Saccharomyces cerevisiae; uncharacterized protein 154430 4985410 An12g00610 Aspergillus niger uncharacterized protein XP_059601760.1 150602 R 5061 CDS An12g00620 4985411 complement(join(155183..155872,155921..156493,156571..156783,156842..156955,157070..157282)) III 1 NT_166527.1 Title: strong similarity to hypothetical protein EAA61938.1 - Aspergillus nidulans; uncharacterized protein 157282 4985411 An12g00620 Aspergillus niger uncharacterized protein XP_001395150.3 155183 R 5061 CDS An12g00630 4985412 complement(join(157752..157855,158170..158204,158288..158515,158571..158700,158751..158789,158837..159024,159095..159335,159400..159607)) III 1 NT_166527.1 Catalytic activity: Triacylglycerol + H2O = Diacylglycerol + a Carboxylate; Diacylglycerol + H2O = Monoacylglycerol + a Carboxylate.; Pathway: Glycerolipid metabolism.; Remark: Escherichia coli cells with a disrupted diacylglycerol kinase gene are unable to grow on media containing arbutin due to a lethal accumulation of diacylglycerol.; Title: strong similarity to triacylglycerol lipase Tgl2 - Saccharomyces cerevisiae; See PMID 9544243; uncharacterized protein 159607 4985412 An12g00630 Aspergillus niger uncharacterized protein XP_059601761.1 157752 R 5061 CDS An12g00640 4985413 complement(join(160087..160260,160347..160447,160500..160531,160576..160631,160668..160706,160763..160765)) III 1 NT_166527.1 Catalytic activity: ATP + H2O = ADP + Orthophosphate.; Pathway: oxidative phosphorylation; Photosynthesis; ATP Synthase.; Remark: non-integral membrane component of the membrane integral v0 complex of vacuolar atpase. v-atpase is responible for acidifying a variety of intracellular compartment in eukaryotic cells.; Remark: the protein probably couples ATP hydrolysis and proton translocation.; Similarity: similar to the b-subunit of the F-type ATPase.; Title: strong similarity to vacuolar atp synthase subunit g vma10 - Neurospora crassa; See PMID 9559854; See PMID 10748245; uncharacterized protein 160765 4985413 An12g00640 Aspergillus niger uncharacterized protein XP_059601762.1 160087 R 5061 CDS An12g00650 4985414 join(161054..161149,161212..161385) III 1 NT_166527.1 Remark: the nuclear genes PET117 and PET191 are required for the assembly of active cytochrome c oxidase in S. cerevisiae, yet their gene products are not subunits of the final assembled cytochrome c oxidase complex.; Title: similarity to assembly factor of cytochrome c oxidase Pet117 - Saccharomyces cerevisiae; See PMID 8381337; See PMID 8811190; uncharacterized protein 161385 4985414 An12g00650 Aspergillus niger uncharacterized protein XP_001395153.1 161054 D 5061 CDS An12g00660 4985415 join(162676..163166,163224..163537,163589..163749,163806..164108,164169..164384) III 1 NT_166527.1 Catalytic activity: L-Tryptophan + O2 = N-Formylkynurenine.; Pathway: Tryptophan metabolism.; Remark: The depletion of an essential amino acid (aa), tryptophan, caused by interferon-gamma (IFN-gamma)-mediated induction of indoleamine 2,3-dioxygenase (IDO) in mouse allografted tumor cells, has been suggested as a reason for the allograft rejection.; Title: similarity to indoleamine 2,3-dioxygenase IDO - Mus musculus; See PMID 1937018; uncharacterized protein 164384 4985415 An12g00660 Aspergillus niger uncharacterized protein XP_001395154.1 162676 D 5061 CDS An12g00670 4985416 164709..165860 III 1 NT_166527.1 Catalytic activity: Cinnamyl alcohol + NADP+ = Cinnamaldehyde + NADPH.; Pathway: flavonoids, stilbene and lignin biosynthesis.; Remark: acts on coniferyl alcohol, sinapyl alcohol,4-coumaryl alcohol and cinnamyl alcohol.; Title: strong similarity to cinnamyl-alcohol dehydrogenase CAD14 - Nicotiana tabacum; See PMID 9788995; See PMID 10322194; See PMID 1643282; uncharacterized protein 165860 4985416 An12g00670 Aspergillus niger uncharacterized protein XP_059601763.1 164709 D 5061 CDS An12g00680 10098108 complement(join(167287..168474,168795..168829,168946..169660)) III 1 NT_166527.1 Remark: it contains a Fungal Zn(2)-Cys(6) binuclear cluster domain.; Title: similarity to gene expression regulator At14 from patent WO200257456-A2 - Unclassified organism; nucleus; uncharacterized protein 169660 10098108 An12g00680 Aspergillus niger uncharacterized protein XP_003188865.2 167287 R 5061 CDS An12g00690 4985418 join(170368..172779,172828..173329,173397..173866) III 1 NT_166527.1 Title: strong similarity to hypothetical protein CAD21497.1 - Neurospora crassa; uncharacterized protein 173866 4985418 An12g00690 Aspergillus niger uncharacterized protein XP_001395157.1 170368 D 5061 CDS An12g00695 84592455 175111..175347 III 1 NT_166527.1 hypothetical protein 175347 84592455 An12g00695 Aspergillus niger hypothetical protein XP_059601764.1 175111 D 5061 CDS An12g00700 4985420 complement(join(177790..178371,178445..178746,178804..178933)) III 1 NT_166527.1 Catalytic activity: a Phenyl acetate + H2O = a Phenol + Acetate.; Title: weak similarity to arylesterase EST1 -Acetobacter pasteurianus; See PMID 11330700; uncharacterized protein 178933 4985420 An12g00700 Aspergillus niger uncharacterized protein XP_001395159.1 177790 R 5061 CDS An12g00710 4985421 complement(join(179705..180301,180357..180548)) III 1 NT_166527.1 Title: strong similarity to hypothetical protein CAD21276.1 - Neurospora crassa; uncharacterized protein 180548 4985421 An12g00710 Aspergillus niger uncharacterized protein XP_001395160.1 179705 R 5061 CDS An12g00720 4985422 complement(join(182214..182376,182439..186046)) III 1 NT_166527.1 Catalytic activity: nucleoside triphosphate + RNA(n) = pyrophosphate + RNA(n+1).; Remark: catalyses DNA-template-directed extention of the 3'- end of an RNA strand by one nucleotide at a time. can initiate a chain de novo.; Remark: in eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized.; Remark: the enzyme needs DNA as template.; Title: strong similarity to 138 kD subunit of DNA-dependent RNA polymerase II rpb2p - Schizosaccharomyces pombe; nucleus; See PMID 10605121; See PMID 10916156; uncharacterized protein 186046 4985422 An12g00720 Aspergillus niger uncharacterized protein XP_059601765.1 182214 R 5061 CDS An12g00730 4985423 complement(join(186436..186455,186578..186622,186683..186800,186856..187140,187194..187708,187759..187852,187900..188134,188194..188300,188356..188597,188655..188709,188757..188783)) III 1 NT_166527.1 Remark: conserved hypothetical protein in different organisms, Schizosaccharomyces pombe, Drosophila melanogaster, Arabidopsis thaliana, Caenorhabditis elegans.; Title: strong similarity to hypothetical conserved protein SPAC1952.06c - Schizosaccharomyces pombe; uncharacterized protein 188783 4985423 An12g00730 Aspergillus niger uncharacterized protein XP_001395162.3 186436 R 5061 CDS An12g00740 4985425 join(189152..189271,189348..189401) III 1 NT_166527.1 Title: weak similarity to mitochondrial protein TOM6 - Neurospora crassa; uncharacterized protein 189401 4985425 An12g00740 Aspergillus niger uncharacterized protein XP_001395164.3 189152 D 5061 CDS An12g00750 84592456 join(190738..191136,191189..193075) III 1 NT_166527.1 Remark: functional studies have shown that the amdR genes are highly conserved and functionally interchangeable between the two species.; Remark: inactivation of the A. oryzae gene results in the inability to grow on gamma-amino-butyric acid (GABA) as a carbon and/or nitrogen source indicating that GABA utilization is amdR-dependent in A. oryzae as it is in A. nidulans.; Remark: the positively acting regulatory gene amdR of Aspergillus nidulans coordinately regulates the expression of five structural genes involved in the catabolism of certain amides (amdS), omega amino acids (gatA and gabA), and lactams (lamA and lamB) in the presence of omega amino acid inducers.; Title: strong similarity to transcription regulator amdR - Aspergillus oryzae; See PMID 2188110; See PMID 1452021; uncharacterized protein 193075 84592456 An12g00750 Aspergillus niger uncharacterized protein XP_059601766.1 190738 D 5061 CDS An12g00760 4985426 complement(join(193518..193735,193818..194256,194309..194928,194987..195070,195134..195245)) III 1 NT_166527.1 Catalytic activity: Nicotinate D-ribonucleotide + Pyrophosphate = Nicotinate + 5-Phospho-alpha-D-ribose 1-diphosphate.; Pathway: nicotinate and nicotinamide metabolism.; Remark: htere is a homology to bacterial nicotinate phosphoribosyl transferase.; Title: strong similarity to hypothetical nicotinate phosphoribosyltransferase Npt1 - Saccharomyces cerevisiae; See PMID 7030616; See PMID 8516295; See PMID 10218108; uncharacterized protein 195245 4985426 An12g00760 Aspergillus niger uncharacterized protein XP_001395165.1 193518 R 5061 CDS An12g00770 4985427 196353..197609 III 1 NT_166527.1 Remark: similarity with the human candidate tumor suppressorp33(ING1).; Remark: the yeast protein is a component of NuA4 histone acetyltransferase complex.; Title: similarity to tumour suppressor p33ING1b ING1 - Homo sapiens; nucleus; See PMID 10805724; See PMID 10866301; See PMID 11076655; uncharacterized protein 197609 4985427 An12g00770 Aspergillus niger uncharacterized protein XP_001395166.1 196353 D 5061 CDS An12g00780 4985428 complement(join(198215..199058,199094..199350)) III 1 NT_166527.1 Catalytic activity: Nucleoside triphosphate + RNA(n) = Pyrophosphate + RNA(n+1).; Remark: in yeast it is an essential subunit, since inactivation by deletion or nonsense mutations led to a recessive lethal phenotype.; Title: strong similarity to 31 kD subunit of NADH:ubiquinone reductase - Neurospora crassa; nucleus; See PMID 10384303; See PMID 1400451; uncharacterized protein 199350 4985428 An12g00780 Aspergillus niger uncharacterized protein XP_059601767.1 198215 R 5061 CDS An12g00790 4985429 join(199889..199953,200042..200235,200294..201032,201089..201680,201740..201888,202126..202276) III 1 NT_166527.1 Remark: STI1 may play a role in mediating the heat shock response of some HSP70 genes.; Title: strong similarity to stress-induced protein Sti1 - Saccharomyces cerevisiae; See PMID 2674681; See PMID 10567567; uncharacterized protein 202276 4985429 An12g00790 Aspergillus niger uncharacterized protein XP_001395168.3 199889 D 5061 CDS An12g00800 4985430 join(205975..206187,206263..206325,206412..206667,206726..209137,209192..209332,209385..209527,209581..210915) III 1 NT_166527.1 Remark: Immunoblotting revealed that vp115 was not actually a component of the glucose transporter-containing vesicles, was most abundant in the plasma membranes and high density microsome fractions of rat adipocytes, and was expressed in all the major rat tissues.; Title: strong similarity to C2-domain family vesicle protein GLUT4 - Rattus norvegicus; See PMID 10350628; uncharacterized protein 210915 4985430 An12g00800 Aspergillus niger uncharacterized protein XP_001395169.1 205975 D 5061 CDS An12g00810 84592457 complement(join(211752..211942,212067..212173,212244..212296)) III 1 NT_166527.1 hypothetical protein 212296 84592457 An12g00810 Aspergillus niger hypothetical protein XP_059601768.1 211752 R 5061 CDS An12g00820 4985432 join(214518..214619,215453..216916) III 1 NT_166527.1 Catalytic activity: UTP + alpha-D-Glucose 1-phosphate = Pyrophosphate + UDPglucose.; Pathway: pentose and glucuronate interconversions; Galactose metabolism; Starch and sucrose metabolism; Nucleotide sugars metabolism.; Remark: in yeast a few percent of enzymatic activities leading to the formation of UDP-Glc appears sufficient to provide the UDP-Glc demands required for cell viability.; Remark: the loss of function of UGP1 is lethal mainly because of the inability of yeast cells to properly form the cell wall.; Title: strong similarity to UTP-glucose-1-phosphate uridylyltransferase Ugp1 - Saccharomyces cerevisiae; See PMID 9159472; See PMID 1481573; uncharacterized protein 216916 4985432 An12g00820 Aspergillus niger uncharacterized protein XP_001395171.1 214518 D 5061 CDS An12g00830 4985433 join(217660..217775,218012..218171,218277..218876,218990..219141,219211..219387,219417..219791,219912..220503) III 1 NT_166527.1 Remark: nit-4, a pathway-specific regulatory gene in the nitrogen circuit of Neurospora crassa, is required for the expression of nit-3 and nit-6, the structural genes which encode nitrate and nitrite reductase, respectively.; Remark: there is another homologous regulatory gene from Aspergillus nidulans, nirA, which encodes a protein whose amino-terminal half has approximately 60% amino acid identity with NIT4 but whose carboxy terminus is completely different.; Title: strong similarity to nitrogen assimilation regulatory protein nit-4 - Neurospora crassa; nucleus; See PMID 1922075; See PMID 1840634; uncharacterized protein 220503 4985433 An12g00830 Aspergillus niger uncharacterized protein XP_059601769.1 217660 D 5061 CDS An12g00840 4985434 join(220980..221516,221633..222345,222404..223631) III 1 NT_166527.1 Remark: activation target is probably a protein or proteins in the basal initiation complex.; Remark: the protein contains the fungal Zn(2)-Cys(6) binuclear cluster domain.; Title: strong similarity to transcription factor ntf1p - Schizosaccharomyces pombe; See PMID 8163491; uncharacterized protein 223631 4985434 An12g00840 Aspergillus niger uncharacterized protein XP_059601770.1 220980 D 5061 CDS An12g00850 4985435 complement(join(225194..227262,227351..227429)) III 1 NT_166527.1 Function: co-expression of het-e and het-c lead to cell death.; Function: het-e1 of P. anserina is responsible for vegetative incompatibility.; Remark: het-e1 of P. anserina shows also two sequence motifs, a GTP-binding domain and a repeated region that shares similarity with that of the beta-transducin.; Remark: the A. niger gene is only one half of the lenght of the P. anserina protein.; Remark: the reactivity of the HET-E protein depends on two functional elements, a GTP-binding domain and several WD40 repeats.; Title: similarity to beta transducin-like protein het-e1 - Podospora anserina; See PMID 7557402; uncharacterized protein 227429 4985435 An12g00850 Aspergillus niger uncharacterized protein XP_001395174.3 225194 R 5061 CDS An12g00860 84592458 complement(228356..231451) III 1 NT_166527.1 Remark: the protein contains a domain of glutamine rich residues.; Title: similarity to hypothetical protein AAN36787.1 - Plasmodium falciparum; uncharacterized protein 231451 84592458 An12g00860 Aspergillus niger uncharacterized protein XP_059601771.1 228356 R 5061 CDS An12g00870 4985437 complement(join(233025..233165,233492..233777,233836..234132,234194..234562,234616..234701)) III 1 NT_166527.1 Remark: Ssu1p mediates efflux of the free form of sulphite.; Title: strong similarity to sulfite resistant protein Ssu1 - Saccharomyces cerevisiae; See PMID 8082198; See PMID 9294463; See PMID 10870099; uncharacterized protein 234701 4985437 An12g00870 Aspergillus niger uncharacterized protein XP_059601772.1 233025 R 5061 CDS An12g00880 4985438 complement(join(235515..235600,235898..236095,236200..236239,236415..236450,236551..236742,236854..237268,237323..237962,238120..238655,238713..238738)) III 1 NT_166527.1 Catalytic activity: 1,2-Bis(4-hydroxy-3-methoxyphenyl)ethylene + O2 = 2 Vanillin.; Remark: the A. niger protein seems c-terminal 200 aa to long.; Remark: the enzyme catalyses oxidative cleavage of the interphenyl double bond in the synthetic substrate and lignin-derived stilbenes. It is responsible for the degradation of a diarylpropane-type structure in lignin.; Title: strong similarity to neoxanthin cleavage enzyme NC1 - Arabidopsis thaliana; See PMID 10611388; See PMID 11006307; uncharacterized protein 238738 4985438 An12g00880 Aspergillus niger uncharacterized protein XP_059601773.1 235515 R 5061 CDS An12g00890 4985439 join(240329..241258,241316..241549,241602..241923,241995..243696,243760..244715,244768..245729,245814..245960) III 1 NT_166527.1 Title: weak similarity to ankyrin Ank2 - Mus musculus; See PMID 8486643; uncharacterized protein 245960 4985439 An12g00890 Aspergillus niger uncharacterized protein XP_059601774.1 240329 D 5061 CDS An12g00900 4985440 join(246194..247663,247729..248151) III 1 NT_166527.1 Remark: the protein shows only in a small part homology and is 300 aa longer as the homologous protein.; Title: weak similarity to nucleic acid-associated protein 36 BAA90827.1 - Asterina pectinifera; See PMID 10632699; uncharacterized protein 248151 4985440 An12g00900 Aspergillus niger uncharacterized protein XP_001395179.1 246194 D 5061 CDS An12g00910 4985441 join(249550..249590,249660..250950) III 1 NT_166527.1 Catalytic activity: Phosphatidyl-L-serine = Phosphatidylethanolamine + CO2.; Pathway: Glycine, serine and threonine metabolism; Glycerolipid metabolism.; Remark: The yeast S. cerevisiae expresses two phosphatidylserine decarboxylase (PSD) activities which are responsible for conversion of phosphatidylserine to phosphatidylethanolamine, and either enzyme alone is sufficient for normal cellular growth.; Remark: the phosphatidylserine decarboxylases show great lenght variation in different organisms.; Title: similarity to phosphatidylserine decarboxylase Psd2 - Saccharomyces cerevisiae; See PMID 7890740; See PMID 10793889; uncharacterized protein 250950 4985441 An12g00910 Aspergillus niger uncharacterized protein XP_001395180.1 249550 D 5061 CDS An12g00920 4985442 complement(join(251434..251817,251871..252013,252067..252835)) III 1 NT_166527.1 Catalytic activity: 6-Carboxyhexanoyl-CoA + L-Alanine = 8-Amino-7-oxononanoate + CoA + CO2.; Pathway: biotin metabolism.; Remark: strong similarity to many 8-amino-7-oxononanoate synthases from different organisms.; Title: strong similarity to transmembrane protein from patent WO9927105-A2 - Chlamydia pneumoniae; See PMID 9914476; See PMID 10642176; uncharacterized protein 252835 4985442 An12g00920 Aspergillus niger uncharacterized protein XP_001395181.1 251434 R 5061 CDS An12g00930 4985443 complement(254784..256190) III 1 NT_166527.1 Remark: Tri101 appears to be a defense option which the producers have independently acquired in addition to their original resistance mechanisms.; Title: strong similarity to trichothecene 3-O-acetyltransferase TRI101 - Gibberella zeae; See PMID 9762900; See PMID 10960733; uncharacterized protein 256190 4985443 An12g00930 Aspergillus niger uncharacterized protein XP_001395182.1 254784 R 5061 CDS An12g00940 4985444 complement(join(256803..256964,257072..257096,257214..257220,257277..257290,257340..258886)) III 1 NT_166527.1 Remark: SVOP and SV2 are more distantly related to eukaryotic and bacterial phosphate, sugar, and organic acid transporters.; Title: similarity to SV2 related protein SVOP -Rattus norvegicus; See PMID 9801366; See PMID 9868370; uncharacterized protein 258886 4985444 An12g00940 Aspergillus niger uncharacterized protein XP_001395183.3 256803 R 5061 CDS An12g00950 4985445 complement(join(259520..259992,260049..260250,260303..260341,260398..261024)) III 1 NT_166527.1 Catalytic activity: Random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans.; Gene-ID: rhgA; Remark: the differences in the protein sequence could be determined among sequencing errors or strain variations.; See PMID 8929397; See PMID 9212401; rhamnogalacturonase rhgA-Aspergillus niger 261024 rhgA 4985445 rhgA Aspergillus niger rhamnogalacturonase rhgA-Aspergillus niger XP_001395184.1 259520 R 5061 CDS An12g00960 4985446 complement(join(261912..262696,262765..262828)) III 1 NT_166527.1 Remark: the dna sequenz is identical to the untranslatetd region of the rhgA gen in the following ORF.; Title: strong similarity to hypothetical protein ydcF - Escherichia coli; uncharacterized protein 262828 4985446 An12g00960 Aspergillus niger uncharacterized protein XP_001395185.3 261912 R 5061 CDS An12g00970 84592459 join(263873..264285,264365..264614,264695..264865) III 1 NT_166527.1 Title: similarity to hypothetical protein encoded by An11g00960 - Aspergillus niger; uncharacterized protein 264865 84592459 An12g00970 Aspergillus niger uncharacterized protein XP_059601775.1 263873 D 5061 CDS An12g00980 4985448 join(266532..267312,267377..268419,268665..268875,268998..269098) III 1 NT_166527.1 Remark: weak similarity to small domains of different transcription factors.; Title: similarity to hypothetical protein encoded by An18g01730 - Aspergillus niger; uncharacterized protein 269098 4985448 An12g00980 Aspergillus niger uncharacterized protein XP_059601776.1 266532 D 5061 CDS An12g00990 84592460 join(269863..269993,270101..270176) III 1 NT_166527.1 Title: questionable ORF; uncharacterized protein 270176 84592460 An12g00990 Aspergillus niger uncharacterized protein XP_059601777.1 269863 D 5061 CDS An12g01000 4985450 join(273186..275267,275408..275439,275508..275708,275864..275874,276013..276044,276094..276225) III 1 NT_166527.1 Catalytic activity: acetylcholine + H2O = choline + acetate.; Function: Che1 of B. floridae hydrolyzes acetylthiocholine and butyrylthiocholine.; Remark: Che1 of B. floridae possesses an ethanolamine-glycan-phosphatidylinositol-anchor and most of the protein is anchored in vivo.; Remark: the ORF is longer than Che1 of B. floridae (829 compared to 605 amino acids), the similarity between the two proteins extends over a stretch of about 250 amino acids.; Title: strong similarity to cholinesterase 1 ChE1 -Branchiostoma floridae; See PMID 9062997; See PMID 9874207; uncharacterized protein 276225 4985450 An12g01000 Aspergillus niger uncharacterized protein XP_001395189.3 273186 D 5061 CDS An12g01010 4985451 complement(join(276715..278232,278279..278392)) III 1 NT_166527.1 Similarity: the ORF is proline-rich and thus has unspecific blast hits to some proteins.; Title: weak similarity to hypothetical protein encoded by An02g01890 - Aspergillus niger; uncharacterized protein 278392 4985451 An12g01010 Aspergillus niger uncharacterized protein XP_059601778.1 276715 R 5061 CDS An12g01020 4985452 join(283006..283046,283138..283541,283606..284076,284136..284959) III 1 NT_166527.1 Catalytic activity: acetamidases catalyze the conversion of a Monocarboxylic acid amide + H2O = a Monocarboxylate + NH3.; Function: the amdS gene codes for an acetamidase enzyme that hydrolyses acetamide to acetate and ammonium thus providing A. nidulans with a source of carbon and nitrogen.; Title: strong similarity to acetamidase amdS -Aspergillus nidulans; See PMID 7847883; uncharacterized protein 284959 4985452 An12g01020 Aspergillus niger uncharacterized protein XP_001395191.1 283006 D 5061 CDS An12g01030 4985453 join(286903..287626,287695..288202,288264..289002) III 1 NT_166527.1 Similarity: blast hits result from repetitive sequences.; Title: similarity to hypothetical protein encoded by An06g00830 - Aspergillus niger; uncharacterized protein 289002 4985453 An12g01030 Aspergillus niger uncharacterized protein XP_001395192.1 286903 D 5061 CDS An12g01040 4985454 complement(join(289706..291185,291245..291365,291403..291847)) III 1 NT_166527.1 Remark: predicted protein is probably to long at the aminoterminus.; Title: similarity to hypothetical membrane protein YMR221c - Saccharomyces cerevisiae; uncharacterized protein 291847 4985454 An12g01040 Aspergillus niger uncharacterized protein XP_059601779.1 289706 R 5061 CDS An12g01050 84592461 join(294315..294325,294460..295180) III 1 NT_166527.1 hypothetical protein 295180 84592461 An12g01050 Aspergillus niger hypothetical protein XP_059601780.1 294315 D 5061 CDS An12g01060 4985456 complement(join(297272..297940,298011..298534,298593..298876,298927..300335)) III 1 NT_166527.1 Function: contains a fungal Zn(2)-Cys(6) binuclear cluster and shows similarity to proteins with this domain,thus it might be involved in regulation of transcription.; Similarity: similarity region to crg1 of C. nicotianae covers aminoacids 300-700.; Title: similarity to cercosporin resistance protein crg1 - Cercospora nicotianae; uncharacterized protein 300335 4985456 An12g01060 Aspergillus niger uncharacterized protein XP_001395195.1 297272 R 5061 CDS An12g01070 4985457 complement(join(301571..302224,302291..303280)) III 1 NT_166527.1 Remark: the blast results suggest this ORF to be split into two, but due to the blast match against TREMBL:SPBC36B7_5 we do not split this ORF.; Similarity: shows similarity to proteins containing the zinc-binding RING finger motif related FYVE finger motif.; Title: weak similarity to phosphatidylinositol(3)-phosphate binding protein Pib1 -Saccharomyces cerevisiae; uncharacterized protein 303280 4985457 An12g01070 Aspergillus niger uncharacterized protein XP_001395196.1 301571 R 5061 CDS An12g01080 4985458 complement(join(304778..307643,307721..308301)) III 1 NT_166527.1 Function: contains several domains that are typical for transporter and shows similarity to proteins containing those motifs (compare to PFAM results).; Title: similarity to hypothetical integral membrane protein SPCC1322.03 - Schizosaccharomyces pombe; uncharacterized protein 308301 4985458 An12g01080 Aspergillus niger uncharacterized protein XP_059601781.1 304778 R 5061 CDS An12g01090 84592462 join(310095..310118,310195..310223,310299..310436,310688..310806,311007..311116,311318..311460,311845..311882,311918..312000) III 1 NT_166527.1 hypothetical protein 312000 84592462 An12g01090 Aspergillus niger hypothetical protein XP_059601782.1 310095 D 5061 CDS An12g01100 4985460 join(315027..317781,317829..318026,318085..318136,318191..318537,318599..318672) III 1 NT_166527.1 Similarity: blast hits result from repetive sequences.; hypothetical protein 318672 4985460 An12g01100 Aspergillus niger hypothetical protein XP_001395199.1 315027 D 5061 CDS An12g01110 4985461 join(318946..319107,319173..320210) III 1 NT_166527.1 Remark: the family of Cys/Met metabolism PLP-dependent enzymes includes enzymes involved in cysteine and methionine metabolism.; Similarity: shows similarity to different members belonging to the family of Cys/Met metabolism PLP-dependent enzymes.; Title: similarity to cystathionine beta-lyase metC -Lactococcus lactis; uncharacterized protein 320210 4985461 An12g01110 Aspergillus niger uncharacterized protein XP_001395200.1 318946 D 5061 CDS An12g01120 84592463 320516..320782 III 1 NT_166527.1 Function: cnxG of A. nidulans is involved in the conversion of precursor Z to molybdopterin, the intermediate section of the molybdenum cofactor biosynthetic pathway.; Title: strong similarity to molybdopterin synthase small subunit cnxG - Aspergillus nidulans; See PMID 10383438; uncharacterized protein 320782 84592463 An12g01120 Aspergillus niger uncharacterized protein XP_059601783.1 320516 D 5061 CDS An12g01130 4985463 complement(join(321037..321223,321359..321612,321705..321863)) III 1 NT_166527.1 hypothetical protein 321863 4985463 An12g01130 Aspergillus niger hypothetical protein XP_059601784.1 321037 R 5061 CDS An12g01140 4985464 join(324871..325047,325104..325441,325504..328126) III 1 NT_166527.1 Function: CYT-4 is thought to regulate mitochondrial RNA splicing by protein phosphorylation.; Remark: no later publications (than 1992) confirming the proposed function of CYT4 as phosphorylase were found. therefore a ribonuclease function of CYT4 might be possible.; Similarity: CYT-4 is similar to the SSD1/SRK1 protein of S. cerevisiae and the DIS3 protein of S. pombe,which have been implicated in protein phosphatase functions that regulate cell cycle and mitotic chromosome segregation.; Similarity: ORF is also similar to many ribonucleases.; Title: strong similarity to protein phosphatase CYT-4 - Neurospora crassa; localisation:mitochondrion; See PMID 2478417; See PMID 1311848; uncharacterized protein 328126 4985464 An12g01140 Aspergillus niger uncharacterized protein XP_059601785.1 324871 D 5061 CDS An12g01150 4985465 complement(join(328338..328512,328566..328732,328786..328893,328960..329819,329862..330057)) III 1 NT_166527.1 Function: The TRI4 geneproduct catalyzes the first oxygenation step in the trichothecene pathway and participates in apotrichodiol biosynthesis.; Remark: trichothecenes are sesquiterpene mycotoxins produced by various species of fungi, which can occur on various agricultural products.; Similarity: The TRI4 gene has been placed in a new cytochrome P450 gene family designated CY P58.; Title: strong similarity to cytochrome P450 trichodiene oxygenase TRI4 - Fusarium sporotrichioides; See PMID 7651333; uncharacterized protein 330057 4985465 An12g01150 Aspergillus niger uncharacterized protein XP_059601786.1 328338 R 5061 CDS An12g01160 84592464 join(330681..330729,331053..331115,331318..331482,331566..331608,331701..331845) III 1 NT_166527.1 hypothetical protein 331845 84592464 An12g01160 Aspergillus niger hypothetical protein XP_059601787.1 330681 D 5061 CDS An12g01170 4985467 complement(join(332172..332212,332307..332545,332600..333516,333581..333882,333947..334325)) III 1 NT_166527.1 Function: MatB is part of a three gene cluster (matABC) encoding the malonate-metabolizing system,malonate-->malonyl-CoA-->acetyl-CoA, in R. trifolii.; Similarity: the ORF encoded protein also shows strong similarity to long-chain-fatty-acid-CoA ligases of different species.; Title: strong similarity to malonyl CoA synthase matB - Rhizobium trifolii; uncharacterized protein 334325 4985467 An12g01170 Aspergillus niger uncharacterized protein XP_001395206.3 332172 R 5061 CDS An12g01180 4985468 join(334892..335005,335076..335182,335244..335421) III 1 NT_166527.1 Title: similarity to protein fragment SEQ ID NO:35753 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 335421 4985468 An12g01180 Aspergillus niger uncharacterized protein XP_001395207.3 334892 D 5061 CDS An12g01190 4985469 complement(join(336170..336237,336295..336574,336625..337091,337161..337266,337376..337381)) III 1 NT_166527.1 Function: SSO1 and SSO2 of yeast encode syntaxin homologs (post-Golgi t-SNAREs), they act in late stages of secretion.; Remark: SNAREs (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptors) are cytoplasmically oriented membrane proteins that reside on vesicular carriers (v-SNARE) and target organelles (t-SNARE). The pairing of a stage-specific v-SNARE with its cognate t-SNARE may mediate the specificity of membrane traffic.; Title: strong similarity to syntaxin-related protein (T-SNARE) Sso2 - Saccharomyces cerevisiae; See PMID 8223426; uncharacterized protein 337381 4985469 An12g01190 Aspergillus niger uncharacterized protein XP_001395208.1 336170 R 5061 CDS An12g01200 84592465 complement(join(337420..337540,337764..337982,338121..338310,338564..338702,338830..338951,339049..339124)) III 1 NT_166527.1 hypothetical protein 339124 84592465 An12g01200 Aspergillus niger hypothetical protein XP_059601788.1 337420 R 5061 CDS An12g01210 4985471 complement(join(340939..342320,342376..342710,342872..342903)) III 1 NT_166527.1 Function: PTR2 of S. cerevisiae facilitates the uptake of small peptides.; Localization: PTR2 of S. cerevisiae is a integral membrane protein.; Similarity: PTR2 of S. cerevisiae belongs to the PTR2 transporter family.; Title: strong similarity to peptide transport protein Ptr2 - Saccharomyces cerevisiae; plasma membrane; See PMID 8264579; uncharacterized protein 342903 4985471 An12g01210 Aspergillus niger uncharacterized protein XP_001395210.1 340939 R 5061 CDS An12g01220 84592466 join(343228..343451,343555..343606,343711..343851,343899..344027,344091..344293,344400..344458,344797..344944,345026..345160,345363..345407,345479..345629) III 1 NT_166527.1 Title: questionable ORF; uncharacterized protein 345629 84592466 An12g01220 Aspergillus niger uncharacterized protein XP_059601789.1 343228 D 5061 CDS An12g01230 84592467 join(345677..345820,345952..346023) III 1 NT_166527.1 hypothetical protein 346023 84592467 An12g01230 Aspergillus niger hypothetical protein XP_059601790.1 345677 D 5061 CDS An12g01250 4985475 complement(join(348164..348343,348409..349190,349303..349489,349611..349796)) III 1 NT_166527.1 Remark: the transport of pyruvate and lactate across cellular membranes is an essential process in mammalian cells and is mediated by the H+/monocarboxylate transporters (MCTs).; Title: strong similarity to monocarboxylate transporter 4 MCT4 - Mus musculus; See PMID 10926847; uncharacterized protein 349796 4985475 An12g01250 Aspergillus niger uncharacterized protein XP_059601791.1 348164 R 5061 CDS An12g01260 4985476 join(350651..350896,350963..351119,351186..351214,351277..351752,351803..351857) III 1 NT_166527.1 Catalytic activity: Nitrile + H2O = Carboxylate + NH3.; Function: The nitrilase genes of A. thaliana (NIT1-4) encode very similar proteins that hydrolyze indole-3-acetonitrile to the phytohormone indole-3-acetic acid.; Remark: Gene structure was manually adjusted fit the Arabidopsis nit1 gene.; Title: strong similarity to nitrilase NIT1 -Arabidopsis thaliana; See PMID 1555601; See PMID 8022831; uncharacterized protein 351857 4985476 An12g01260 Aspergillus niger uncharacterized protein XP_059601792.1 350651 D 5061 CDS An12g01270 84592468 complement(join(351971..352075,352192..352977)) III 1 NT_166527.1 Similarity: This ORF is also similar to many hypothetical proteins with similar lenth.; Similarity: hypothetical protein has similarity to C-terminal part of many alanyl-tRNA synthetases.; Title: similarity to hypothetical alanine--tRNA ligase alaS - Streptomyces coelicolor; uncharacterized protein 352977 84592468 An12g01270 Aspergillus niger uncharacterized protein XP_059601793.1 351971 R 5061 CDS An12g01280 4985478 complement(353497..354741) III 1 NT_166527.1 Catalytic activity: ATP + L-Citrulline + L-Aspartate = AMP + Pyrophosphate + N(omega)-(L-Arginino)succinate.; Title: strong similarity to argininosuccinate synthase argG - Streptomyces clavuligerus; See PMID 8566818; uncharacterized protein 354741 4985478 An12g01280 Aspergillus niger uncharacterized protein XP_001395216.3 353497 R 5061 CDS An12g01290 84592469 complement(356241..>356747) III 1 NT_166527.1 remark: N-terminally truncated ORF due to end of contig.; hypothetical protein [truncated ORF] 356747 84592469 An12g01290 Aspergillus niger hypothetical protein [truncated ORF] XP_059601794.1 356241 R 5061 CDS An12g01300 84592470 join(357650..358091,358200..358310,358355..358923,359037..360341) III 1 NT_166527.1 Function: in N. crassa, the fusion of hyphae of opposite mating type during vegetative growth results in growth inhibition and cell death, a process that is mediated by the tol locus.; Regulation: tol transcription is repressed to allow the coexistence of opposite mating-type nuclei during the sexual reproductive phase.; Remark: mutations in tol are recessive and suppress mating-type-associated heterokaryon incompatibility.; Title: similarity to vegetative incompatibility protein tol - Neurospora crassa; See PMID 9449795; See PMID 9927450; uncharacterized protein 360341 84592470 An12g01300 Aspergillus niger uncharacterized protein XP_059601795.1 357650 D 5061 CDS An12g01310 4985481 complement(join(361210..361532,361599..362516,362596..362779)) III 1 NT_166527.1 Similarity: ORF is also similar to hypothetical peptidoglycan binding domain protein, a and beta-mannosidase precursor and a glucan 1,3-beta-glucosidase.; Title: strong similarity to hypothetical protein PA2063 - Pseudomonas aeruginosa; uncharacterized protein 362779 4985481 An12g01310 Aspergillus niger uncharacterized protein XP_001395219.1 361210 R 5061 CDS An12g01320 4985482 join(363700..364131,364207..364371,364449..364557,364610..364699,364760..365102,365173..365959,366021..366082,366142..366618,366687..367107,367174..367407,367467..367743,368016..368164) III 1 NT_166527.1 Function: Linoleate diol synthase is a homotetrameric ferric hemeprotein, which catalyzes dioxygenation of linoleic acid to (8R)-hydroperoxylinoleate and isomerization of the hydroperoxide to (7S,8S)-dihydroxylinoleate.; Remark: The linoleate diol synthase is a cyclooxygenase-related dioxygenase.; Similarity: Belongs to family of fatty acid heme dioxygenases.; Similarity: The linoleate diol synthase is similar to prostaglandin H synthases.; Title: strong similarity to linoleate diol synthase - Gaeumannomyces graminis; See PMID 10497176; See PMID 10667399; uncharacterized protein 368164 4985482 An12g01320 Aspergillus niger uncharacterized protein XP_059601796.1 363700 D 5061 CDS An12g01330 4985483 complement(join(369557..370024,370085..370156,370221..370424)) III 1 NT_166527.1 Remark: The eIF4E gene of S. pombe encodes the cap-binding component eIF4E.; Title: strong similarity to translation initiation factor eIF-4E - Schizosaccharomyces pombe; uncharacterized protein 370424 4985483 An12g01330 Aspergillus niger uncharacterized protein XP_001395221.1 369557 R 5061 CDS An12g01340 4985484 complement(join(370969..370977,371020..371026,371112..371126,371268..371288,371367..371730,371841..371932,372177..372187)) III 1 NT_166527.1 Function: Adult mice homozygous for the Mpv17 deletion developed nephrotic syndrome and chronic renal failure.; Similarity: ORF is also similar to peroxisomal membrane proteins.; Title: strong similarity to hypothetical protein mpv17 - Mus musculus; uncharacterized protein 372187 4985484 An12g01340 Aspergillus niger uncharacterized protein XP_059605505.1 370969 R 5061 CDS An12g01350 4985485 join(372676..372939,373117..373374,373445..373702) III 1 NT_166527.1 Function: S4 of yeast is important in the assembly and function of the 40S ribosomal subunit.; Function: mutations in S4 of yeast affect the control of translational fidelity.; Remark: S4 of yeast is also called omnipotent suppressor protein SUP44.; Similarity: S4 of yeast belongs to the S5p family of ribosomal proteins.; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S4 - Saccharomyces cerevisiae; cytoplasm; See PMID 2247072; 40S ribosomal protein uS5 373702 4985485 An12g01350 Aspergillus niger 40S ribosomal protein uS5 XP_001395223.1 372676 D 5061 CDS An12g01360 4985486 join(374778..375186,375241..375275,375327..376139,376192..376713) III 1 NT_166527.1 Cofactor: Heme.; Similarity: Similarity to many different cytochrome P450 proteins.; Title: strong similarity to hypothetical cytochrome P450 protein 2E4.050 - Neurospora crassa; uncharacterized protein 376713 4985486 An12g01360 Aspergillus niger uncharacterized protein XP_001395224.1 374778 D 5061 CDS An12g01370 4985487 join(377802..377904,377985..378762,378822..379188,379285..379329,379558..379692,379999..380031,380113..380655) III 1 NT_166527.1 Similarity: Most weak blast hits are caused by repetetive sequence elements.; Title: similarity to hypothetical protein encoded by An04g06340 - Aspergillus niger; uncharacterized protein 380655 4985487 An12g01370 Aspergillus niger uncharacterized protein XP_001395225.3 377802 D 5061 CDS An12g01380 4985488 join(381873..382314,382369..382948,382986..383145) III 1 NT_166527.1 Cofactor: NADPH.; Function: krd of Z. rouxii catalyzes the asymmetric reduction of selected ketone substrates.; Function: krd of Z. rouxii reduces alpha-ketolactones, alpha-ketolactams, and diketones.; Similarity: Similarity to many different reductases.; Similarity: krd of Z. rouxii belongs to the carbonyl reductase enzyme class.; Title: strong similarity to ketoreductase krd -Zygosaccharomyces rouxii; See PMID 10951208; uncharacterized protein 383145 4985488 An12g01380 Aspergillus niger uncharacterized protein XP_059605506.1 381873 D 5061 CDS An12g01400 84592471 384131..385249 III 1 NT_166527.1 hypothetical protein 385249 84592471 An12g01400 Aspergillus niger hypothetical protein XP_059605507.1 384131 D 5061 CDS An12g01410 84592472 join(386515..386574,386757..386970,387307..387364,387485..387658,387828..388006,388171..388266,388315..388423,388580..388706,389036..389115,389325..389555,389739..389830,389998..390141,390184..390282,390388..390584) III 1 NT_166527.1 Title: questionable ORF; uncharacterized protein 390584 84592472 An12g01410 Aspergillus niger uncharacterized protein XP_059605508.1 386515 D 5061 CDS An12g01420 84592473 join(390798..390800,390851..391072,391192..391210,391263..391402) III 1 NT_166527.1 Title: weak similarity to hypothetical helicase protein Cag-omega from cagI pathogenicity island -Helicobacter pylori; See PMID 8962108; uncharacterized protein 391402 84592473 An12g01420 Aspergillus niger uncharacterized protein XP_059605509.1 390798 D 5061 CDS An12g01430 84592474 join(392442..392550,392742..392907,393252..393321,393393..393521,393599..393676) III 1 NT_166527.1 hypothetical protein 393676 84592474 An12g01430 Aspergillus niger hypothetical protein XP_059605510.1 392442 D 5061 CDS An12g01440 84592475 join(393954..394165,394251..394350,394439..394653,394929..395118,395266..395436) III 1 NT_166527.1 Title: weak similarity to hypothetical cation efflux system protein czcB3 - Aquifex aeolicus; uncharacterized protein 395436 84592475 An12g01440 Aspergillus niger uncharacterized protein XP_059605511.1 393954 D 5061 CDS An12g01460 4985496 complement(join(396669..396750,396808..396942,396997..397484,397546..397612,397676..397821)) III 1 NT_166527.1 Function: NOP-1 may function as a rhodopsin in N. crassa photobiology.; Function: Opsins are a class of retinal-binding,seven transmembrane helix proteins that function as light-responsive ion pumps or sensory receptors.; Remark: nop-1 expression of N. crassa is regulated by light and conidiation.; Title: strong similarity to opsin nop-1 - Neurospora crassa; See PMID 10393943; See PMID 10571987; uncharacterized protein 397821 4985496 An12g01460 Aspergillus niger uncharacterized protein XP_001395233.1 396669 R 5061 CDS An12g01470 4985497 complement(399072..400637) III 1 NT_166527.1 Title: strong similarity to hypothetical protein encoded by An12g01780 - Aspergillus niger; uncharacterized protein 400637 4985497 An12g01470 Aspergillus niger uncharacterized protein XP_001395234.1 399072 R 5061 CDS An12g01480 4985498 complement(401349..404366) III 1 NT_166527.1 Catalytic activity: ATP + L-Isoleucine + tRNA(Ile) = AMP + Pyrophosphate + L-Isoleucyl-tRNA(Ile).; Title: strong similarity to mitochondrial isoleucine--tRNA ligase Ism1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 6304034; See PMID 7607232; uncharacterized protein 404366 4985498 An12g01480 Aspergillus niger uncharacterized protein XP_001395235.1 401349 R 5061 CDS An12g01490 4985499 complement(join(404745..406216,406270..406333)) III 1 NT_166527.1 Complex: KIF17, a molecular motor interacts with the PDZ domain of mouse Lin-10 (Mint1/X11), which is a constituent of a large protein complex including mLin-2 (CASK), mLin-7 (MALS/Velis) and the NR2B subunit of the NMDA receptor.; Complex: rat lin-10 interacts with neurabin-II/spinophilin, which has recently been isolated as a protein interacting with protein phosphatase I and F-actin.; Function: lin-10 is required for the targeting of transmembrane receptors to the basolateral surface via specific cytosceleton dependent transport.; Localization: rat lin-10 is distributed in both the cytosol and membrane fractions.; Title: similarity to transport regulator lin-10 -Rattus norvegicus; intracellular transport vesicles; See PMID 9480860; See PMID 9514910; See PMID 10610414; See PMID 10846156; uncharacterized protein 406333 4985499 An12g01490 Aspergillus niger uncharacterized protein XP_001395236.1 404745 R 5061 CDS An12g01500 4985500 join(406841..409477,409527..410462) III 1 NT_166527.1 Function: A. nidulans bimC mutations interfere with separation of the spindle pole bodies, cause abnormal spindle morphology and prevent nuclear division.; Title: strong similarity to kinesin-like mitotic spindle organising factor bimC - Aspergillus nidulans; See PMID 2138511; uncharacterized protein 410462 4985500 An12g01500 Aspergillus niger uncharacterized protein XP_001395237.1 406841 D 5061 CDS An12g01510 10098110 complement(join(410920..412059,412140..412332,412511..412587,412645..412676,412745..413069)) III 1 NT_166527.1 Remark: the systematic name for S. cerevisiae APC11 is YDL008w.; Similarity: similarity is from the N-terminal region of the predicted A. niger protein to the N-terminal half of the S. cerevisiae RING-finger protein APC11, which is 400 aa shorter.; Similarity: the predicted A. niger protein contains a RING-finger domain.; Title: similarity to RING-finger ubiquitin ligases (E3) Apc11 - Saccharomyces cerevisiae; See PMID 10888670; uncharacterized protein 413069 10098110 An12g01510 Aspergillus niger uncharacterized protein XP_059605512.1 410920 R 5061 CDS An12g01520 4985502 join(413287..414206,414267..414321) III 1 NT_166527.1 Function: human TST catalyzes the transfer of sulfur in thiosulfate and other compounds to cyanide ion to form thiocyanate ion; Localization: TST localises in the mitochondrial matrix in animal tissues.; Title: strong similarity to thiosulfate sulfurtransferase TST - Homo sapiens; localisation:mitochondrion; See PMID 1953758; uncharacterized protein 414321 4985502 An12g01520 Aspergillus niger uncharacterized protein XP_001395239.3 413287 D 5061 CDS An12g01530 4985503 join(414768..414807,415013..415204,415258..416385,416579..416691) III 1 NT_166527.1 Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger EST an_2527.; Remark: the systematic name for S. cerevisiae RGD1 is YBR260c.; Title: weak similarity to Rho3 and Rho4 GTPase activating protein Rgd1 - Saccharomyces cerevisiae; See PMID 10526184; uncharacterized protein 416691 4985503 An12g01530 Aspergillus niger uncharacterized protein XP_001395240.3 414768 D 5061 CDS An12g01540 4985504 join(417332..417483,417562..417662,417731..417909) III 1 NT_166527.1 Similarity: the ORF shows strong similarity to EST EMBLEST:BE760874 an_0852 - Aspergillus niger.; Similarity: the predicted A. niger protein contains a DNA-binding motif and shows similarity to the putative DNA-binding domain of a fusion protein resulting from chromosomal rearrangements in human acute megakaryoblastic leukemias.; Title: similarity to hypothetical protein dJ1042K10.5 - Homo sapiens; See PMID 11431691; uncharacterized protein 417909 4985504 An12g01540 Aspergillus niger uncharacterized protein XP_001395241.1 417332 D 5061 CDS An12g01550 4985505 complement(join(418224..418863,418929..419122)) III 1 NT_166527.1 Complex: human Trax (Translin-associated factor X) has been shown to interact with TB-RBP/Translin by its coimmunoprecipitation and in yeast two-hybrid assays,forming heterodimers.; Function: Translin/TB-RBP is a single-stranded DNA-and RNA-binding protein which can bind the 3' UTR regions (Y and H elements) of stored mRNAs and can suppress in vitro translation of the mRNAs that contain these sequences.; Function: human Trax-Translin/TB-RBP interactions modulate the DNA- and RNA-binding activity of Translin/TB-RBP, while Trax has no DNA/RNA-binding activity by itself.; Localization: cell fractionation and confocal microscope studies reveal that human Trax is predominantly cytoplasmic.; Title: similarity to modifier of Translin DNA/RNA-binding Trax - Homo sapiens; cytoplasm; See PMID 9013868; See PMID 11027506; uncharacterized protein 419122 4985505 An12g01550 Aspergillus niger uncharacterized protein XP_001395242.1 418224 R 5061 CDS An12g01560 4985506 complement(join(419522..419674,419728..420729,420779..420964,421018..421040,421162..421342)) III 1 NT_166527.1 Function: N. crassa QA-Y was identified as quinic acid permease by sequence similarity and mutant phenotype.; Similarity: N. crassa QA-Y belongs to the major facilitator family.; Title: strong similarity to quinic acid permease QA-Y - Neurospora crassa; See PMID 2976880; See PMID 1533844; uncharacterized protein 421342 4985506 An12g01560 Aspergillus niger uncharacterized protein XP_059605513.1 419522 R 5061 CDS An12g01570 4985507 join(421655..421960,422028..422657) III 1 NT_166527.1 Catalytic activity: gluconolactonases convert D-glucono-1,5-lactone + H(2)O to D-gluconate; Function: gluconolactonase is involved in the biosynthesis of different monosaccharides, like ribose and xylulose, from glucose.; Title: strong similarity to gluconolactonase -Zymomonas mobilis; See PMID 1482681; uncharacterized protein 422657 4985507 An12g01570 Aspergillus niger uncharacterized protein XP_001395244.1 421655 D 5061 CDS An12g01580 4985508 complement(422713..423684) III 1 NT_166527.1 Catalytic activity: A. thaliana PGDH catalyses the oxidation of 3-phosphoglycerate to phosphohydroxypyruvate.; Function: A. thaliana PGDH is involved in serine biosynthesis.; Similarity: similarity is from the predicted A. niger protein to the N-terminal half of A. thaliana PGDH,which is 300 aa longer.; Title: similarity to 3-phosphoglycerate dehydrogenase PGDH - Arabidopsis thaliana; See PMID 9867856; uncharacterized protein 423684 4985508 An12g01580 Aspergillus niger uncharacterized protein XP_001395245.1 422713 R 5061 CDS An12g01590 4985509 complement(join(423847..423933,424001..424576,424622..424673,424730..425602,425686..425782,425867..425971,426175..426184)) III 1 NT_166527.1 Function: S. cerevisiae PPR1 regulates expression of pyrimidine biosynthetis genes.; Similarity: the predicted A. niger protein shows similarity to several fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain containing transcription factors,however it contains no such domain by itself.; Title: similarity to transcription activator Ppr1 -Saccharomyces cerevisiae; nucleus; See PMID 6278253; See PMID 7958913; uncharacterized protein 426184 4985509 An12g01590 Aspergillus niger uncharacterized protein XP_059605514.1 423847 R 5061 CDS An12g01600 4985510 join(426660..426734,426765..426997,427052..427204,427261..427552,427692..428930) III 1 NT_166527.1 Function: S. cerevisiae PPR1 regulates expression of pyrimidine biosynthetis genes.; Similarity: the predicted A. niger protein shows similarity to several fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain containing transcription factors,however it contains no such domain by itself.; Title: similarity to transcription activator Ppr1 -Saccharomyces cerevisiae; nucleus; See PMID 6278253; See PMID 7958913; uncharacterized protein 428930 4985510 An12g01600 Aspergillus niger uncharacterized protein XP_059605515.1 426660 D 5061 CDS An12g01610 4985511 complement(428977..429801) III 1 NT_166527.1 Catalytic activity: macrophomate synthase converts 5-acetyl-4-methoxy-6-methyl-2-pyrone (1) to 4-acetyl-3-methoxy-5-methylbenzoic acid (macrophomic acid,2). -; Function: macrophomate synthase is a Mg(II)-dependent dimeric enzyme that catalyzes an extraordinary, complex five-step chemical transformation from 2-pyrone and oxalacetate to benzoate involving decarboxylation, C-C bond formation, and dehydration.; Title: similarity to macrophomate synthase -Macrophoma commelinae; See PMID 10731719; See PMID 10984474; uncharacterized protein 429801 4985511 An12g01610 Aspergillus niger uncharacterized protein XP_001395248.1 428977 R 5061 CDS An12g01620 4985512 complement(join(430094..430141,430443..430579,430662..430681,430711..430910,430967..431702,431755..431969)) III 1 NT_166527.1 Function: in B. cepacia 4-hydroxyphthalate,4-chlorophthalate, 4-methylphthalate, and cinchomeronate compete for the phthalate permease.; Title: strong similarity to phthalate permease ophD - Burkholderia cepacia; plasma membrane; See PMID 10498738; uncharacterized protein 431969 4985512 An12g01620 Aspergillus niger uncharacterized protein XP_059605516.1 430094 R 5061 CDS An12g01630 4985513 complement(join(432049..432264,432482..432733,432790..433003,433065..433195,433250..433352,433402..433663,433713..433785,433875..433892,433952..434460,434540..434645)) III 1 NT_166527.1 Title: strong similarity to hypothetical protein EAA59080.1 - Aspergillus nidulans; uncharacterized protein 434645 4985513 An12g01630 Aspergillus niger uncharacterized protein XP_059605517.1 432049 R 5061 CDS An12g01640 4985514 join(435213..436361,436427..436861) III 1 NT_166527.1 Remark: blastp with the predicted A. niger protein only retrieves putative random hits to serine and proline rich proteins.; Title: weak similarity to mucin - Sus scrofa; uncharacterized protein 436861 4985514 An12g01640 Aspergillus niger uncharacterized protein XP_001395251.3 435213 D 5061 CDS An12g01650 84592476 complement(join(438164..438975,439487..440708)) III 1 NT_166527.1 Similarity: the predicted A. niger protein contains an ankyrin motif.; Title: similarity to polypeptide SEQ ID NO 29028 from patent WO200171042-A2 - Drosophila melanogaster; uncharacterized protein 440708 84592476 An12g01650 Aspergillus niger uncharacterized protein XP_059605518.1 438164 R 5061 CDS An12g01660 84592477 complement(join(441063..441509,442167..442260,442349..442495,442812..442841,442947..442974,443063..443666,443886..443966)) III 1 NT_166527.1 Similarity: the predicted A. niger protein contains an ankyrin motif.; Title: weak similarity to vertebrate left-right axis determinant inversin inv - Mus musculus; See PMID 9771707; uncharacterized protein 443966 84592477 An12g01660 Aspergillus niger uncharacterized protein XP_059605519.1 441063 R 5061 CDS An12g01670 4985517 join(445166..446305,446372..447163) III 1 NT_166527.1 Catalytic activity: monophenol monooxygenases convert L-tyrosine + L-DOPA + O(2) to L-DOPA + DOPAquinone + H(2)O.; Function: tyrosinase is a copper containing monooxygenase catalyzing the formation of melanin pigments and other polyphenolic compounds from various phenols.; Title: strong similarity to tyrosinase melO -Aspergillus oryzae; See PMID 6308414; See PMID 7893753; uncharacterized protein 447163 4985517 An12g01670 Aspergillus niger uncharacterized protein XP_001395254.1 445166 D 5061 CDS An12g01680 4985518 join(448204..448250,448306..448913,448961..449197,449247..449860) III 1 NT_166527.1 Title: weak similarity to oxidoreductase OXRD-8 from patent DE29916782-U1 - Homo sapiens; uncharacterized protein 449860 4985518 An12g01680 Aspergillus niger uncharacterized protein XP_059605520.1 448204 D 5061 CDS An12g01690 84592478 join(450371..450431,450560..450641,450812..450857) III 1 NT_166527.1 Title: similarity to hypothetical protein F2J6.1 -Arabidopsis thaliana; uncharacterized protein 450857 84592478 An12g01690 Aspergillus niger uncharacterized protein XP_059605521.1 450371 D 5061 CDS An12g01700 4985520 join(451379..451768,451839..452264,452324..452470,452532..453227) III 1 NT_166527.1 Function: S. cerevisiae CHA4 is involved in transcriptional activation of catabolic L-serine (L-threonine) deaminase via the serine/threonine response element.; Similarity: similarity is between the N-terminal 2/3s of the predicted A. niger protein and S. cerevisiae CHA4, which is 100 aa longer.; Similarity: the predicted A. niger protein contains a N-terminal fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain.; Title: similarity to transcription activator Cha4 -Saccharomyces cerevisiae; nucleus; See PMID 8889513; uncharacterized protein 453227 4985520 An12g01700 Aspergillus niger uncharacterized protein XP_001395257.1 451379 D 5061 CDS An12g01710 4985521 complement(join(454020..454166,454230..454298,454357..454950,455010..455099)) III 1 NT_166527.1 Function: might be a short chain dehydrogenase of unknown specificity.; Remark: the patent comprises novel human nucleic acid sequences from tumor breast tissue which have cytostatic activity.; Similarity: shows strong similarity to probable short chain dehydrogenases of different organisms.; Title: strong similarity to human breast tumour-associated protein 77 from patent DE19813839-A1 -Homo sapiens; uncharacterized protein 455099 4985521 An12g01710 Aspergillus niger uncharacterized protein XP_001395258.3 454020 R 5061 CDS An12g01720 84592479 join(455445..455530,455640..455937) III 1 NT_166527.1 Function: patent WO9957280-A2 covers neisserial polypeptides predicted to be useful antigens for vaccines and diagnostics SEQ ID NO:124.; Similarity: covers only a part of the patent sequence.; Title: weak similarity to ORF 297 protein sequence from patent WO9957280-A2 - Neisseria meningitidis; uncharacterized protein 455937 84592479 An12g01720 Aspergillus niger uncharacterized protein XP_059605522.1 455445 D 5061 CDS An12g01730 4985523 complement(<456558..457492) III 1 NT_166527.1 Function: the family of short chain dehydrogenases contains a wide variety of dehydrogenases involved in for example glycolysis/gluconeogenesis, fatty acid metabolism,bile acid biosynthesis, etc.; Function: the gene encoding this sequence of patent JP09075093-A are specifically expressed during the growth of cotton fibre.; Remark: blast hit against protein of patent JP09075093-A.; Remark: putative sequencing error around pos. 73231.; Similarity: predicted protein shows strong similarity to probable oxidoreductase of different organisms.; Title: strong similarity to cotton fibrous tissue specific protein from patent JP09075093-A - Gossypium barbadense [putative frameshift]; putative frameshift; uncharacterized protein 457492 4985523 An12g01730 Aspergillus niger uncharacterized protein XP_059605523.1 456558 R 5061 CDS An12g01750 4985525 complement(join(459778..460316,460534..460792)) III 1 NT_166527.1 Title: strong similarity to hypothetical protein CAD21295.1 - Neurospora crassa; uncharacterized protein 460792 4985525 An12g01750 Aspergillus niger uncharacterized protein XP_059605524.1 459778 R 5061 CDS An12g01760 84592480 join(461979..462334,462387..462419,462487..462856) III 1 NT_166527.1 Similarity: shows only short similarity to protein of B. burgdorferi.; Title: weak similarity to antigen P93 from patent WO9512676-A1 - Borrelia burgdorferi; uncharacterized protein 462856 84592480 An12g01760 Aspergillus niger uncharacterized protein XP_059605525.1 461979 D 5061 CDS An12g01770 84592481 complement(join(463647..463775,463828..464223)) III 1 NT_166527.1 Similarity: shows only short partial similarity to human protein.; Title: weak similarity to gastric mucin MUC5AC -Homo sapiens; uncharacterized protein 464223 84592481 An12g01770 Aspergillus niger uncharacterized protein XP_059605526.1 463647 R 5061 CDS An12g01780 84592482 complement(465390..466946) III 1 NT_166527.1 Remark: protein of the patent is useful useful for diagnosis or vaccine production.; Title: weak similarity to viral protein encoded by ORF1 of ET-NANB (HEV) Burma strain from patent US5824649-A - Hepatitis E virus; uncharacterized protein 466946 84592482 An12g01780 Aspergillus niger uncharacterized protein XP_059605527.1 465390 R 5061 CDS An12g01790 84592483 complement(join(467287..468119,468261..468291)) III 1 NT_166527.1 Title: similarity to hypothetical protein encoded by An06g00800 - Aspergillus niger; uncharacterized protein 468291 84592483 An12g01790 Aspergillus niger uncharacterized protein XP_059605528.1 467287 R 5061 CDS An12g01800 4985530 join(468822..468926,468993..471941) III 1 NT_166527.1 Function: it is a alpha-1,3-glucanase; alpha-1,3-glucanohydrolase.; Function: mutanase is composed of two distinct domains: a NH(2)-terminal catalytic domain and a putative COOH-terminal polysaccharide-binding domain separated by a O-glycosylated Pro-Ser-Thr-rich linker peptide.; Remark: same enzyme of T. harzianum is patented WO9818437-A1 and used as component for dental care products.; Similarity: shows similarity to the aminoterminal part of mutanase of several fungi.; Title: similarity to mutanase mutA - Trichoderma harzianum; See PMID 10636904; uncharacterized protein 471941 4985530 An12g01800 Aspergillus niger uncharacterized protein XP_001395266.1 468822 D 5061 CDS An12g01810 84592484 complement(join(472766..472946,473268..473391,473499..473568)) III 1 NT_166527.1 Similarity: shows only partial similarity at the aminoterminus.; Title: weak similarity to glutamine--tRNA ligase QARS - Homo sapiens; uncharacterized protein 473568 84592484 An12g01810 Aspergillus niger uncharacterized protein XP_059605529.1 472766 R 5061 CDS An12g01820 4985532 join(474251..474472,474721..475416) III 1 NT_166527.1 Catalytic activity: ubiquitin C-terminal thiolester + H(2)O = ubiquitin + a thiol.; Similarity: shows strong similarity to several ubiquitin thiolesterase but is around 100 AA longer at the aminoterminus.; Title: similarity to ubiquitin thiolesterase L3 -Homo sapiens; See PMID 2530630; uncharacterized protein 475416 4985532 An12g01820 Aspergillus niger uncharacterized protein XP_059605530.1 474251 D 5061 CDS An12g01830 84592485 complement(join(476393..476516,476759..477088,477299..477392,477476..477620,477741..477932)) III 1 NT_166527.1 Title: weak similarity to hypothetical ATP-binding protein bax - Escherichia coli; uncharacterized protein 477932 84592485 An12g01830 Aspergillus niger uncharacterized protein XP_059605531.1 476393 R 5061 CDS An12g01840 84592486 complement(join(477972..477991,478338..478349,478524..479709)) III 1 NT_166527.1 Title: similarity to hypothetical protein related to meiosis-specific protein NDT80 - Neurospora crassa; uncharacterized protein 479709 84592486 An12g01840 Aspergillus niger uncharacterized protein XP_059605532.1 477972 R 5061 CDS An12g01850 4985535 complement(join(480419..481198,481251..481486,481540..481970,482017..482970,483035..483168)) III 1 NT_166527.1 Function: glycosidase enzymes from organisms of the genera Staphlothermus, Pyrococcus and Thermococcus - for deriving sugar from oligosaccharides, useful in the e. g. food processing, textile or baking industries.; Localization: might be an extracellular/secreted protein.; Title: strong similarity to glycosidase from patent WO9824799-A1 - Thermotoga maritima; See PMID 11210501; See PMID 11210502; uncharacterized protein 483168 4985535 An12g01850 Aspergillus niger uncharacterized protein XP_001395271.1 480419 R 5061 CDS An12g01860 84592487 484257..484529 III 1 NT_166527.1 hypothetical protein 484529 84592487 An12g01860 Aspergillus niger hypothetical protein XP_059605533.1 484257 D 5061 CDS An12g01870 4985537 join(486311..487438,487486..488484) III 1 NT_166527.1 Similarity: might be longer at the aminoterminus because blast search showed similarity at pos. 44141-43934.; Similarity: shows only partial similarity to several transcription factors.; Title: similarity to positive regulator of the lactose-galactose regulon LAC9 - Kluyveromyces lactis; nucleus; uncharacterized protein 488484 4985537 An12g01870 Aspergillus niger uncharacterized protein XP_001395273.3 486311 D 5061 CDS An12g01880 4985538 join(489222..490214,490286..490393,490724..490845,490888..490921) III 1 NT_166527.1 Function: PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER and glycosylphosphatidylinositol (GPI) acts as a membrane anchor of many cell surface proteins.; Title: strong similarity to mannosyltransferase PIG-M - Homo sapiens; endoplasmatic reticulum; See PMID 11226175; uncharacterized protein 490921 4985538 An12g01880 Aspergillus niger uncharacterized protein XP_059605534.1 489222 D 5061 CDS An12g01890 4985539 complement(join(491177..491284,491333..491515,491568..492627,492715..492782)) III 1 NT_166527.1 Function: the central isoprenoid pathway concerned with the synthesis of prenyl lipids is present in C. utilis and active in the biosynthesis of ergosterol.; Function: the influential steps in the pathway that were manipulated were 3-hydroxy methylglutaryl coenzyme A (HMG-CoA) reductase, encoded by the HMG gene, and squalene synthase, encoded by the ERG9 gene.; Function: through metabolic engineering of the isoprenoid pathway, a sevenfold increase in the yield of lycopene has been achieved.; Title: strong similarity to squalene synthase ERG9 -Candida utilis; See PMID 9647847; uncharacterized protein 492782 4985539 An12g01890 Aspergillus niger uncharacterized protein XP_001395275.1 491177 R 5061 CDS An12g01900 4985540 join(493698..493803,493850..493893,493962..494055,494106..495142,495208..495351) III 1 NT_166527.1 Function: DnaJ homologues act in conjunction with molecular chaperones of the Hsp70 protein family in a variety of cellular processes.; Localization: the S. cerevisiae DJP1 gene encodes a cytosolic protein homologous to Escherichia coli DnaJ.; Title: strong similarity to dnaJ protein homolog YIR004w - Saccharomyces cerevisiae; cytoplasm; See PMID 9679141; uncharacterized protein 495351 4985540 An12g01900 Aspergillus niger uncharacterized protein XP_001395276.1 493698 D 5061 CDS An12g01910 4985541 join(496602..497032,497099..497166,497257..497383,497445..498309) III 1 NT_166527.1 Function: phytase as component of a feed composition for monogastric animals (e. g., pigs, poultry) enhances the nutritional value of plant material without the need for adding additional phosphate to the feed.; Function: the enzyme showed high activity with 4-nitrophenyl phosphate at a pH range of 3 to 5 and with phytic acid at a pH range of 2. 5 to 7. 5.; Function: the gene (phyA3) encoding a heat-stable enzyme has been cloned from A. fumigatus and overexpressed in A. niger.; Remark: shows also high similarity to patent EP969089-A1 that describes a consensus protein sequence (included is A. niger).; Title: strong similarity to phytase phyA3 -Aspergillus fumigatus; extracellular/secretion proteins; uncharacterized protein 498309 4985541 An12g01910 Aspergillus niger uncharacterized protein XP_059605535.1 496602 D 5061 CDS An12g01920 4985542 complement(join(498609..500713,500820..500829)) III 1 NT_166527.1 Title: strong similarity to hypothetical protein Pa5G0034 - Podospora anserina; uncharacterized protein 500829 4985542 An12g01920 Aspergillus niger uncharacterized protein XP_001395278.3 498609 R 5061 CDS An12g01930 4985543 complement(join(502089..503759,503807..503950)) III 1 NT_166527.1 Function: expression of the mouse cDNA in cultured mouse cells resulted in a nearly 10-fold increase in the incidence of point mutations.; Function: the E. coli dinB gene is an SOS gene known to be required for lambda phage untargeted mutagenesis.; Function: the product DinB is structurally related to the E. coli UmuC protein and the S. cerevisiae Rev1 and Rad30 proteins, all of which are shown to be involved in bypass synthesis at a DNA lesion.; Similarity: is around 200 AA shorter than the murine protein but longer than other predicted protein with similiar function.; Title: similarity to homologue of the E.coli mutagenesis protein DinB - Mus musculus; See PMID 10620008; uncharacterized protein 503950 4985543 An12g01930 Aspergillus niger uncharacterized protein XP_001395279.1 502089 R 5061 CDS An12g01940 4985544 join(504400..504599,504655..506416) III 1 NT_166527.1 Function: protein of E. nidulans seems to be involved in double-strand break repair.; Remark: paper might be published soon.; Similarity: shows weak similarity to patent WO9955716-A1 (nibrin of H. sapiens).; Title: strong similarity to campothecin resistance conferring protein rcaA - Aspergillus nidulans; uncharacterized protein 506416 4985544 An12g01940 Aspergillus niger uncharacterized protein XP_059605536.1 504400 D 5061 CDS An12g01950 4985545 join(508078..508573,508656..509923) III 1 NT_166527.1 Remark: the ORF shows an significant match against the EST an_2509 from Aspergillus niger.; Title: strong similarity to hypothetical protein CAD60583.1 - Podospora anserina; uncharacterized protein 509923 4985545 An12g01950 Aspergillus niger uncharacterized protein XP_001395281.1 508078 D 5061 CDS An12g01960 4985546 complement(join(510188..510212,510330..510343,510404..510739,510824..511063,511137..511256,511336..511536,511595..511701,511770..511861,511908..511983,512046..512400)) III 1 NT_166527.1 Complex: component of the allantoate transport system.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 3275614; See PMID 10869563; uncharacterized protein 512400 4985546 An12g01960 Aspergillus niger uncharacterized protein XP_001395282.3 510188 R 5061 CDS An12g01970 4985547 join(513843..514150,514205..514864,514928..515045,515238..515286,515418..515461) III 1 NT_166527.1 Title: similarity to hypothetical protein encoded by An01g00420 - Aspergillus niger; uncharacterized protein 515461 4985547 An12g01970 Aspergillus niger uncharacterized protein XP_001395283.3 513843 D 5061 CDS An12g01980 4985548 complement(join(516272..516391,516448..521090,521139..521608,521660..521686,521742..521842)) III 1 NT_166527.1 Catalytic activity: (3r)-3-hydroxyacyl-[acyl-carrier protein] + nadp(+) = 3-oxoacyl-[acyl-carrier protein] + nadph.; Catalytic activity: acetyl-coa + n malonyl-coa + 2n nadph = long-chain fatty acid + (n+1) coa + n co(2) + 2n nadp(+).; Catalytic activity: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + co(2) + [acyl-carrier protein].; Complex: fatty acid synthetase are [alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha & beta).; Complex: this subunit coordinates the binding of the six beta subunits to the enzyme complex.; Function: fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-coa,malonyl-coa and nadph.; Function: the alpha subunit contains domains for: acyl carrier protein, 3-oxoacyl-[acyl-carrier protein] reductase, and 3-oxoacyl-[acyl-carrier-protein] synthase.; Similarity: to the fatty acid synthetase, subunit alpha from other fungi.; Title: strong similarity to fatty acid synthase alpha subunit Fas2 - Saccharomyces cerevisiae; cytoplasm; uncharacterized protein 521842 4985548 An12g01980 Aspergillus niger uncharacterized protein XP_001395284.1 516272 R 5061 CDS An12g01990 4985549 join(522587..527750,527794..528276,528322..528437,528483..528875) III 1 NT_166527.1 Catalytic activity: this subunit of fatty acid synthetase, with five different catalytic activities, bears four distinct domains.; Complex: the yeast fatty acid synthase is a complex (alpha 6 beta 6) of two multifunctional proteins alpha and beta.; Title: strong similarity to fatty-acyl-CoA synthase beta chain fas1p - Schizosaccharomyces pombe; cytoplasm; uncharacterized protein 528875 4985549 An12g01990 Aspergillus niger uncharacterized protein XP_001395285.1 522587 D 5061 CDS An12g02000 4985552 complement(join(<528913..529709,529772..530013,530128..530473)) III 1 NT_166527.1 Catalytic activity: salicylate + NADH + O(2) <=> catechol + NAD(+) + H(2)O + CO(2).; Cofactor: FAD.; Pathway: nahpthalene catabolism and phenylalanine metabolism.; Remark: ORF contains a frameshift, due to a putative sequencing error.; Title: strong similarity to salicylate hydroxylase nahG - Pseudomonas putida [putative frameshift]; putative frameshift; See PMID 2363715; uncharacterized protein 530473 4985552 An12g02000 Aspergillus niger uncharacterized protein XP_059605537.1 528913 R 5061 CDS An12g02010 84592488 join(530670..530869,530969..531038,531412..531537,531577..531624) III 1 NT_166527.1 Similarity: the similarity of the ORF encoded protein to the protein sequence from ORF 982 Neisseria meningitidis is only based on repetitive structures.; Title: weak similarity to hypothetical protein At2g22660 - Arabidopsis thaliana; uncharacterized protein 531624 84592488 An12g02010 Aspergillus niger uncharacterized protein XP_059605538.1 530670 D 5061 CDS An12g02020 84592489 complement(531931..533331) III 1 NT_166527.1 Function: the trichothecene 3-O-acetyltransferase TRI101 from F. sporotrichioides converts isotrichodermol to isotrichodermin.; Function: transfection of TRI101 of F. sporotrichioides into S. cerevisiae, protects the cell from the trichothecene 4,15-diacetoxyscirpenol. Antibiotic-producing organisms, including fungi, protect themselves from their own toxins by e. g. metabolic alteration of the compound.; Pathway: F. sporotrichioides TRI101 is required for the biosynthesis of T-2 toxin.; Remark: Fusarium and related fungi produce trichothecenes which are sesquiterpenoid epoxides that act as potent inhibitors of eukaryotic protein synthesis.; Title: strong similarity to trichothecene 3-O-acetyltransferase TRI101 - Fusarium sporotrichioides; See PMID 8246841; See PMID 10583973; uncharacterized protein 533331 84592489 An12g02020 Aspergillus niger uncharacterized protein XP_059605539.1 531931 R 5061 CDS An12g02030 84592490 complement(join(533769..534014,534165..534282,534358..534658,534763..534911,535001..535116,535164..535217)) III 1 NT_166527.1 Title: weak similarity to hypothetical ATP-binding ABC transporter protein - Deinococcus radiodurans; uncharacterized protein 535217 84592490 An12g02030 Aspergillus niger uncharacterized protein XP_059605540.1 533769 R 5061 CDS An12g02040 4985554 join(535412..535610,535661..535916,535963..536494,536544..537173,537225..537392) III 1 NT_166527.1 Remark: the regulatory Aspergillus niger acuA mutation, which leads to the lost of acetyl-CoA synthetase (ACS) activity can be complemented with the A. niger facB gene.; Similarity: the FacB protein from A. niger is a zinc finger transcription factor of the fungal Zn(2)-Cys(6) binuclear cluster domain type.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus niger; See PMID 10483720; uncharacterized protein 537392 4985554 An12g02040 Aspergillus niger uncharacterized protein XP_001395290.1 535412 D 5061 CDS An12g02050 4985555 join(538565..539068,539125..541958,541999..542079,542125..>546161) III 1 NT_166527.1 Function: the A. nidulans wA PKS gene has been identified to encode a heptaketide naphthopyrone synthase.; Remark: ORF contains a frameshift, due to a putative sequencing error.; Title: strong similarity to polyketide synthase wA -Aspergillus nidulans [putative frameshift]; putative frameshift; See PMID 11251292; uncharacterized protein 546161 4985555 An12g02050 Aspergillus niger uncharacterized protein XP_059605541.1 538565 D 5061 CDS An12g02060 4985556 complement(join(547124..547560,547610..548003)) III 1 NT_166527.1 Title: strong similarity to hypothetical protein encoded by An03g02680 - Aspergillus niger; uncharacterized protein 548003 4985556 An12g02060 Aspergillus niger uncharacterized protein XP_001395292.1 547124 R 5061 CDS An12g02070 4985557 join(548710..549034,549129..549379) III 1 NT_166527.1 Function: the the ribonuclease T1 precursor RntA from Aspergillus oryzae catalyzes degradation of RNA in a two-stage endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in G-P with 2',3'-cyclic phosphate intermediates.; Title: similarity to ribonuclease T1 precursor rntA - Aspergillus oryzae; See PMID 8534978; See PMID 10029539; uncharacterized protein 549379 4985557 An12g02070 Aspergillus niger uncharacterized protein XP_001395293.1 548710 D 5061 CDS An12g02080 4985558 complement(join(<550751..551791,551837..552330)) III 1 NT_166527.1 Function: A. nidulans stcS catalyzes the conversion of versicolorin A to sterigmatocystin.; Pathway: A. nidulans stcS is involved in the sterigmatocystin biosynthesis.; Remark: ORF contains a frameshift, due to a putative sequencing error.; Remark: alternate name for A. nidulans stcS is verB.; Title: strong similarity to cytochrome P450 monooxygenase stcS - Aspergillus nidulans [putative frameshift]; putative frameshift; See PMID 7486998; See PMID 8643646; uncharacterized protein 552330 4985558 An12g02080 Aspergillus niger uncharacterized protein XP_059605542.1 550751 R 5061 CDS An12g02090 4985559 join(553228..553323,553517..553771,553834..554637,554688..554897,554950..555092,555138..555419,555591..555870) III 1 NT_166527.1 Function: nit-4 of N. crassa is a transcription factor activating gene expression of nitrate assimilatory genes nit-3 and nit-6, which encode nitrate reductase and nitrite reductase, respectively.; Remark: activation of nit-3 and nit-6 requires the synergisitc interaction of the global-acting nit-2 with the pathway-specific nit-4 transcription factors.; Similarity: the nit-4 protein from N. crassa is a zinc finger transcription factor of the fungal Zn(2)-Cys(6) binuclear cluster domain type.; Title: strong similarity to nitrogen assimilation regulatory protein nit-4 - Neurospora crassa; nucleus; See PMID 1388109; See PMID 1531376; See PMID 1829047; uncharacterized protein 555870 4985559 An12g02090 Aspergillus niger uncharacterized protein XP_059605543.1 553228 D 5061 CDS An12g02100 4985560 complement(join(555942..556237,556295..556406)) III 1 NT_166527.1 Function: Mmf1p influences the maintenance of mitochondrial DNA (mtDNA) and the cell division time. Mammalian members of this protein family may be implicated in regulation of protein translation.; Localization: electron microscopy immunogold labeling shows that S. cerevisiae Mmf1 is present in the mitochondrial matrix, and analysis of the different submitochondrial fractions demonstrated that Mmf1p is a soluble protein of the matrix.; Remark: alternate names for S. cerevisiae Mmf1: YIL051c or Mmd1.; Similarity: the ORF encoded protein and the S. cerevisiae Mmf1 protein belong to the conserved UK114 protein family.; Title: similarity to mitochondrial matrix factor 1 Mmf1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 11003673; uncharacterized protein 556406 4985560 An12g02100 Aspergillus niger uncharacterized protein XP_001395296.1 555942 R 5061 CDS An12g02110 4985561 556887..558788 III 1 NT_166527.1 Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: strong similarity to hypothetical protein CAD70448.1 - Neurospora crassa; uncharacterized protein 558788 4985561 An12g02110 Aspergillus niger uncharacterized protein XP_059605544.1 556887 D 5061 CDS An12g02120 4985562 560100..561161 III 1 NT_166527.1 Similarity: the similarities of the ORF encoded protein to matching proteins with an E-val less than 3e-11 are mainly based on repetitive structures.; Title: similarity to hypothetical mold-specific protein MS8 - Ajellomyces capsulatus; uncharacterized protein 561161 4985562 An12g02120 Aspergillus niger uncharacterized protein XP_001395298.1 560100 D 5061 CDS An12g02130 84592491 join(561735..561892,561957..562154,562204..562270,562300..562443) III 1 NT_166527.1 Title: weak similarity to hypothetical protein KIAA1235 - Homo sapiens; uncharacterized protein 562443 84592491 An12g02130 Aspergillus niger uncharacterized protein XP_059605545.1 561735 D 5061 CDS An12g02150 84592492 complement(join(563927..564034,564148..564214,564292..564497)) III 1 NT_166527.1 Title: questionable ORF; uncharacterized protein 564497 84592492 An12g02150 Aspergillus niger uncharacterized protein XP_059605546.1 563927 R 5061 CDS An12g02160 84592493 join(565036..565280,565387..565441) III 1 NT_166527.1 hypothetical protein 565441 84592493 An12g02160 Aspergillus niger hypothetical protein XP_059605547.1 565036 D 5061 CDS An12g02170 84592494 join(<567158..567509,567566..567711) III 1 NT_166527.1 Remark: truncated ORF due to end of contig.; hypothetical protein [truncated ORF] 567711 84592494 An12g02170 Aspergillus niger hypothetical protein [truncated ORF] XP_059601797.1 567158 D 5061 CDS An12g02175 4985569 join(568295..568348,568425..568511,568575..568787) III 1 NT_166527.1 hypothetical protein 568787 4985569 An12g02175 Aspergillus niger hypothetical protein XP_059601798.1 568295 D 5061 CDS An12g02180 84592495 568995..569345 III 1 NT_166527.1 Title: similarity to hypothetical protein encoded by An12g09970 - Aspergillus niger; uncharacterized protein 569345 84592495 An12g02180 Aspergillus niger uncharacterized protein XP_059601799.1 568995 D 5061 CDS An12g02190 4985570 join(569949..570234,570456..571038,571137..571188) III 1 NT_166527.1 Title: strong similarity to hypothetical protein encoded by An12g09960 - Aspergillus niger; uncharacterized protein 571188 4985570 An12g02190 Aspergillus niger uncharacterized protein XP_059601800.1 569949 D 5061 CDS An12g02200 4985571 complement(join(571569..572288,572347..572472)) III 1 NT_166527.1 Function: the stress induction of Hsp30 acts to reduce stress stimulation of the H+-ATPase.; Induction: expression of S. cerevisiae Hsp30 is induced by heat shock, ethanol treatment, and entry into stationary phase.; Remark: alternate names for S. cerevisiae Hsp30: YRO1 or YCR021C.; Similarity: S. cerevisiae Hsp30 belongs to the archaeal opsin family and to the Hsp30 subfamily.; Title: strong similarity to heat shock protein Hsp30 - Saccharomyces cerevisiae; plasma membrane; See PMID 9250391; See PMID 9414109; See PMID 7812443; uncharacterized protein 572472 4985571 An12g02200 Aspergillus niger uncharacterized protein XP_001395306.1 571569 R 5061 CDS An12g02210 4985572 complement(join(573026..573256,573306..573797,573852..574371,574419..574930)) III 1 NT_166527.1 Similarity: the FacB protein from A. nidulans is a zinc finger transcription factor of the fungal Zn(2)-Cys(6) binuclear cluster domain type.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; See PMID 9197408; uncharacterized protein 574930 4985572 An12g02210 Aspergillus niger uncharacterized protein XP_059601801.1 573026 R 5061 CDS An12g02220 4985573 join(578111..578255,578313..578610,578668..578921,578993..579130,579309..579566,579638..579879,579951..579995) III 1 NT_166527.1 Function: the biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) exocellobiohydrolases that cut the dissaccharide cellobiose from the nonreducing end of the cellulose polymer chain; (3) beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose. CHB2 from Trichoderma reesei is an exocellobiohydrolases.; Title: strong similarity to cellulose 1,4-beta-cellobiosidase II CBH2 - Trichoderma reesei; See PMID 8875646; See PMID 2377893; See PMID 3596237; uncharacterized protein 579995 4985573 An12g02220 Aspergillus niger uncharacterized protein XP_001395308.1 578111 D 5061 CDS An12g02240 4985575 complement(join(581164..581550,581629..582714,582771..583301)) III 1 NT_166527.1 Catalytic activity: ATP + glycine + tRNA(Gly) <=> AMP + diphosphate + glycyl-tRNA(Gly).; Function: the glycyl-tRNA synthetase gene GRS1 encodes both cytoplasmic and mitochondrial activities in S. cerevisiae.; Remark: alternate name for S. cerevisiae Grs1: YBR121C.; Title: strong similarity to glycine--tRNA ligase Grs1 - Saccharomyces cerevisiae; See PMID 10874035; uncharacterized protein 583301 4985575 An12g02240 Aspergillus niger uncharacterized protein XP_001395309.1 581164 R 5061 CDS An12g02250 84592496 complement(join(583764..583988,584024..584190,584288..584309,584368..584376)) III 1 NT_166527.1 hypothetical protein 584376 84592496 An12g02250 Aspergillus niger hypothetical protein XP_059601802.1 583764 R 5061 CDS An12g02280 4985579 join(586677..586710,586762..586922,586983..587114) III 1 NT_166527.1 hypothetical protein 587114 4985579 An12g02280 Aspergillus niger hypothetical protein XP_001395311.1 586677 D 5061 CDS An12g02300 4985581 join(588797..589032,589089..589394,589627..589765) III 1 NT_166527.1 Title: similarity to hypothetical protein encoded by An12g02310 - Aspergillus niger; uncharacterized protein 589765 4985581 An12g02300 Aspergillus niger uncharacterized protein XP_001395312.3 588797 D 5061 CDS An12g02310 84592497 join(590460..590695,590759..591203,591239..591292) III 1 NT_166527.1 Title: similarity to hypothetical protein encoded by An12g02300 - Aspergillus niger; uncharacterized protein 591292 84592497 An12g02310 Aspergillus niger uncharacterized protein XP_059601803.1 590460 D 5061 CDS An12g02320 4985583 complement(join(591621..591625,591693..592473)) III 1 NT_166527.1 Catalytic activity: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP(+) <=> 3-oxoacyl-[acyl-carrier protein] + NADPH.; Pathway: FabG from Salmonella typhimurium catalyzes the first reduction step in the fatty acid biosynthesis pathway.; Similarity: the ORF encoded protein and FabG from Salmonella typhimurium belong to the short-chain dehydrogenases/reductases (SDR) family.; Title: similarity to 3-oxoacyl-(acyl carrier protein) reductase fabG - Salmonella typhimurium; See PMID 9642179; uncharacterized protein 592473 4985583 An12g02320 Aspergillus niger uncharacterized protein XP_059601804.1 591621 R 5061 CDS An12g02330 4985584 complement(join(593253..593684,593762..594371,594495..594667)) III 1 NT_166527.1 Function: the AiiA enzyme from Bacillus sp. 240B1 degrades N-acylhomoserine lactone.; Remark: N-acylhomoserine lactones, known as autoinducers (AIs), are widely conserved signal molecules present in quorum-sensing systems of many gram-negative bacteria.; Similarity: AiiA from Bacillus sp. 240B1 contains a 'HXHXDH' zinc-binding motif that is conserved in several groups of metallohydrolases.; Title: similarity to acylhomoserine lactone signal inactivating enzyme aiiA - Bacillus sp.; See PMID 10716724; uncharacterized protein 594667 4985584 An12g02330 Aspergillus niger uncharacterized protein XP_059601805.1 593253 R 5061 CDS An12g02340 4985585 597692..599278 III 1 NT_166527.1 Function: PnbA from B. subtilis catalyzes the hydrolysis of several beta-lactam antibiotic PNB esters to the corresponding free acid and PNB alcohol.; Title: strong similarity to p-nitrobenzyl esterase pnbA - Bacillus subtilis; See PMID 7828905; uncharacterized protein 599278 4985585 An12g02340 Aspergillus niger uncharacterized protein XP_001395316.1 597692 D 5061 CDS An12g02350 84592498 join(600321..600424,600477..600512,600569..600929,601068..602045) III 1 NT_166527.1 Function: S. cerevisiae Lys14 activates the transcription of lysine biosynthesis genes. This activation is dependent on the inducer alpha-aminoadipate semialdehyde and repressed by lysine.; Remark: alternate name for S. cerevisiae Lys14: YDR034C.; Similarity: the ORF encoded protein also shows significant domain homology to many fungal binuclear Zn(2)-Cys(6) cluster transcription factors.; Title: similarity to transcription activator of lysine pathway Lys14 - Saccharomyces cerevisiae; nucleus; See PMID 7935367; uncharacterized protein 602045 84592498 An12g02350 Aspergillus niger uncharacterized protein XP_059601806.1 600321 D 5061 CDS An12g02360 4985587 join(602441..602548,602607..602784,602858..603434,603515..603658,603714..603963) III 1 NT_166527.1 Catalytic activity: Hippurate + H(2)O <=> benzoate + glycine.; Title: similarity to hippurate hydrolase HipO -Campylobacter jejuni; See PMID 7730270; uncharacterized protein 603963 4985587 An12g02360 Aspergillus niger uncharacterized protein XP_001395318.1 602441 D 5061 CDS An12g02370 4985588 join(605698..606091,606141..606970) III 1 NT_166527.1 Function: the MCT3 protein from rat is a proton-linked monocarboxylate transporter, that catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.; Title: similarity to monocarboxylate transporter MCT3 - Rattus norvegicus; See PMID 9632638; See PMID 9841555; uncharacterized protein 606970 4985588 An12g02370 Aspergillus niger uncharacterized protein XP_059601807.1 605698 D 5061 CDS An12g02380 4985589 complement(join(607246..608114,608181..608433)) III 1 NT_166527.1 Function: the c-ski gene product (c-Ski) was found to bind to N-CoR (nuclear hormone receptor co-repressor),an element implicated in transcriptional repression mediated by multiple transcriptional repressors including the nuclear hormone receptors and Mad. c-Ski is required for transcriptional repression mediated by Mad involved in negative regulation of cellular proliferation.; Title: similarity to transforming protein ski - Homo sapiens; nucleus; See PMID 9371722; See PMID 9988677; uncharacterized protein 608433 4985589 An12g02380 Aspergillus niger uncharacterized protein XP_001395320.3 607246 R 5061 CDS An12g02390 84592499 join(609467..609580,609670..610956) III 1 NT_166527.1 Title: similarity to hypothetical protein CAC28841.2 - Neurospora crassa; uncharacterized protein 610956 84592499 An12g02390 Aspergillus niger uncharacterized protein XP_059601808.1 609467 D 5061 CDS An12g02400 4985591 complement(join(611133..612731,612803..612913)) III 1 NT_166527.1 Title: weak similarity to transcription activator of lysine pathway Lys14 - Saccharomyces cerevisiae; uncharacterized protein 612913 4985591 An12g02400 Aspergillus niger uncharacterized protein XP_001395322.1 611133 R 5061 CDS An12g02410 4985592 join(613649..613788,613851..613996,614055..614472,614780..614805,614877..614911) III 1 NT_166527.1 Function: germins are a family of homopentameric cereal glycoproteins expressed during germination which may play a role in altering the properties of cell walls during germinative growth.; Function: spherulin is a major encystment specific protein.; Similarity: belongs to the germin-like family.; Title: strong similarity to precursor of spherulin 1a - Physarum polycephalum; cell wall; uncharacterized protein 614911 4985592 An12g02410 Aspergillus niger uncharacterized protein XP_001395323.3 613649 D 5061 CDS An12g02420 4985593 join(615819..615908,615980..616261,616313..616639,616693..616956) III 1 NT_166527.1 Function: phenylcoumaran benzylic ether reductases,2'-hydroxyisoflavone reductases and pinoresinol-lariciresinol reductases are involved in the biosynthesis of important and related phenylpropanoid-derived plant defense compounds; Similarity: shows also strong similarity to several plant 2'-hydroxyisoflavone reductases and pinoresinol-lariciresinol reductases.; Title: strong similarity to phenylcoumaran benzylic ether reductase pcbera - Populus trichocarpa; See PMID 10066819; uncharacterized protein 616956 4985593 An12g02420 Aspergillus niger uncharacterized protein XP_001395324.1 615819 D 5061 CDS An12g02430 4985594 join(618042..618652,618711..619133,619177..619486,619552..619655,619718..619877,619930..620040) III 1 NT_166527.1 Catalytic activity: 4-coumarate-CoA ligase catalyzes the conversion of ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA.; Title: strong similarity to 4-coumarate-CoA ligase 4CL1 - Populus trichocarpa; uncharacterized protein 620040 4985594 An12g02430 Aspergillus niger uncharacterized protein XP_001395325.3 618042 D 5061 CDS An12g02440 84592500 join(621440..621572,621637..621857,621964..622087,622135..622506,622556..622580,622639..623979,624033..624494,624694..624846,624943..625511,625580..625599) III 1 NT_166527.1 Title: similarity to hypothetical ATP-binding protein SCCB12.04 - Streptomyces coelicolor; uncharacterized protein 625599 84592500 An12g02440 Aspergillus niger uncharacterized protein XP_059601809.1 621440 D 5061 CDS An12g02450 4985596 complement(join(626037..626085,626150..626663,626769..626974,627042..632163,632219..633021,633109..633262,633360..633720)) III 1 NT_166527.1 Similarity: shows strong similarity to several glucosyltransferases with different specificities.; Title: strong similarity to alpha-glucan synthase mok1p - Schizosaccharomyces pombe; See PMID 10087262; uncharacterized protein 633720 4985596 An12g02450 Aspergillus niger uncharacterized protein XP_059601810.1 626037 R 5061 CDS An12g02460 4985597 635516..637165 III 1 NT_166527.1 Catalytic activity: alpha-amylase catalyses the endohydrolysis of 1,4-alpha-glucosidic linkages in oligosaccharides and polysaccharides.; Function: alpha-amylase acts on starch, glycogen and related polysaccharides and oligosaccharides in a random manner; reducing groups are liberated in the alpha-configuration.; Title: strong similarity to alpha-amylase -Aspergillus niger; uncharacterized protein 637165 4985597 An12g02460 Aspergillus niger uncharacterized protein XP_001395328.3 635516 D 5061 CDS An12g02470 4985598 complement(join(637305..637676,637734..638375)) III 1 NT_166527.1 Similarity: shows similarity to several different oxidoreductases.; Title: similarity to NADPH-protochlorophyllide-oxidoreductase - Pinus mugo; uncharacterized protein 638375 4985598 An12g02470 Aspergillus niger uncharacterized protein XP_001395329.1 637305 R 5061 CDS An12g02480 4985599 join(638742..639063,639117..639427,639478..639660) III 1 NT_166527.1 hypothetical protein 639660 4985599 An12g02480 Aspergillus niger hypothetical protein XP_001395330.1 638742 D 5061 CDS An12g02490 4985600 join(639966..641054,641102..641161) III 1 NT_166527.1 Function: putative transcription factor, due to motifs.; Similarity: shows similarity to several transcriptional regulators, but the homology regions covers always only the zinc finger motif region.; Title: weak similarity to aflatoxin biosynthesis regulator aflR - Aspergillus flavus; uncharacterized protein 641161 4985600 An12g02490 Aspergillus niger uncharacterized protein XP_059601811.1 639966 D 5061 CDS An12g02500 4985601 join(641495..642033,642096..642612) III 1 NT_166527.1 Remark: lovC interacts with LNKS and is necessary for the correct processing of the growing polyketide chain and production of dihydromonacolin L.; Remark: putative part of the lovastatin biosynthesis gene cluster as seen in Aspergillus terreus.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994; uncharacterized protein 642612 4985601 An12g02500 Aspergillus niger uncharacterized protein XP_001395332.1 641495 D 5061 CDS An12g02510 4985602 complement(642848..643885) III 1 NT_166527.1 Similarity: shows some similarity to major capsid protein orf25 of Herpesvirus saimiri.; hypothetical protein 643885 4985602 An12g02510 Aspergillus niger hypothetical protein XP_059601812.1 642848 R 5061 CDS An12g02520 4985603 complement(join(644332..644365,644542..644912,644995..645308,645392..645431)) III 1 NT_166527.1 Remark: patent WO9503416-A.; Remark: the enzyme is used to catalyse the biosynthesis of clavulanic acid from a precursor clavulanic acid aldehyde. The obtained clavulanic acid is in turn a key ingredient in the antibiotic Augmentin.; Title: strong similarity to clavulanic acid dehydrogenase from patent WO9503416-A - Streptomyces clavuligerus; uncharacterized protein 645431 4985603 An12g02520 Aspergillus niger uncharacterized protein XP_059601813.1 644332 R 5061 CDS An12g02540 4985605 complement(join(647954..647975,648032..648406,648444..648530,648819..649058,649112..649154,649210..649729)) III 1 NT_166527.1 Remark: the gene (cel1) expressing the 1. 3-kb mRNA,is differentially regulated by the carbon source of the culture medium.; Title: similarity to cellulose-growth-specific protein cel1 - Agaricus bisporus; See PMID 1398098; uncharacterized protein 649729 4985605 An12g02540 Aspergillus niger uncharacterized protein XP_001395335.3 647954 R 5061 CDS An12g02550 4985606 651572..652384 III 1 NT_166527.1 Remark: strong similarity only to the C-terminus of xynD, as the predicted ORF is 298 amino acids shorter at the N-terminus.; Remark: xynD specifically release only esters of 5-5'diFA from either xylanase-treated or insoluble fractions of cell walls, even though other esterified dimers were solubilized by preincubation with xylanase.; Title: similarity to esterase D xynD - Pseudomonas fluorescens; See PMID 8373350; See PMID 8979352; uncharacterized protein 652384 4985606 An12g02550 Aspergillus niger uncharacterized protein XP_001395336.1 651572 D 5061 CDS An12g02560 4985607 join(653616..653687,653898..653996,654685..655458,655565..655723,655764..655801,655877..655958) III 1 NT_166527.1 Remark: only in the C-terminal domain is weak similarity.; Title: weak similarity to protein-tyrosine phosphatase SH-PTP2 - Rattus norvegicus; See PMID 8048963; uncharacterized protein 655958 4985607 An12g02560 Aspergillus niger uncharacterized protein XP_059601814.1 653616 D 5061 CDS An12g02580 84592501 join(659300..659321,659378..659676) III 1 NT_166527.1 hypothetical protein 659676 84592501 An12g02580 Aspergillus niger hypothetical protein XP_059601815.1 659300 D 5061 CDS An12g02590 4985610 join(660602..660715,660750..661001) III 1 NT_166527.1 Title: similarity to hypothetical protein SPAC10F6.16 - Schizosaccharomyces pombe; uncharacterized protein 661001 4985610 An12g02590 Aspergillus niger uncharacterized protein XP_059601816.1 660602 D 5061 CDS An12g02600 84592502 complement(join(661504..661976,662017..662386,662430..662606,662713..662952)) III 1 NT_166527.1 Remark: Pth11p can activate appressorium differentiation in response to inductive surface cues and repress differentiation on poorly inductive surfaces and that multiple signaling pathways mediate differentiation.; Remark: the Pth11p protein is approximately in the C-terminal region 200 amino acids longer.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529; uncharacterized protein 662952 84592502 An12g02600 Aspergillus niger uncharacterized protein XP_059601817.1 661504 R 5061 CDS An12g02620 84592503 complement(join(663704..665182,665408..665443)) III 1 NT_166527.1 Title: similarity to hypothetical negative acting factor related protein B3E4.130 - Neurospora crassa; uncharacterized protein 665443 84592503 An12g02620 Aspergillus niger uncharacterized protein XP_059601818.1 663704 R 5061 CDS An12g02630 4985614 join(666008..666190,666248..666385,666431..666482,666553..667100) III 1 NT_166527.1 Remark: patent WO9911793-A1.; Remark: the patent is useful in the diagnosis,prevention, and treatment of infectious, vesicle trafficking, immunological, and neoplastic disorders.; Title: strong similarity to actVA-ORF4-like protein A-ORFP from patent WO9911793-A1 - Homo sapiens; uncharacterized protein 667100 4985614 An12g02630 Aspergillus niger uncharacterized protein XP_059601819.1 666008 D 5061 CDS An12g02640 4985615 complement(join(667420..667453,667514..668050,668122..668555)) III 1 NT_166527.1 Remark: patent WO9833896-A2; Remark: the patent protein is useful for producing clavulanic acid without production of 5S clavam or clavam-2-carboxylates.; Title: strong similarity to clavin biosynthesis gene orfup1 from patent WO9833896-A2 - Streptomyces clavuligerus; See PMID 10223939; uncharacterized protein 668555 4985615 An12g02640 Aspergillus niger uncharacterized protein XP_001395343.1 667420 R 5061 CDS An12g02650 4985616 complement(669164..669976) III 1 NT_166527.1 Similarity: the predicted ORF shows similarity to various methyltransferases.; Title: similarity to 24-sterol C-methyltransferase ESMT1 - Zea mays; uncharacterized protein 669976 4985616 An12g02650 Aspergillus niger uncharacterized protein XP_001395344.1 669164 R 5061 CDS An12g02660 84592504 670917..672374 III 1 NT_166527.1 Similarity: the blastp matches are mainly based on repetetive structures.; hypothetical protein 672374 84592504 An12g02660 Aspergillus niger hypothetical protein XP_059601820.1 670917 D 5061 CDS An12g02670 4985618 complement(join(672621..674723,674806..675987,676045..679597,679744..680108,680178..680233,680348..680471,680532..681644)) III 1 NT_166527.1 Remark: fumonisins are toxins associated with several mycotoxicoses and are produced by the maize pathogen Gibberella fujikuroi mating population A (MP-A). Biochemical analyses indicate that fumonisins are a product of either polyketide or fatty acid biosynthesis.; Title: strong similarity to polyketide synthase FUM5 - Gibberella fujikuroi; See PMID 10413619; uncharacterized protein 681644 4985618 An12g02670 Aspergillus niger uncharacterized protein XP_059601821.1 672621 R 5061 CDS An12g02680 4985619 683472..684029 III 1 NT_166527.1 Title: weak similarity to hypothetical protein encoded by An02g12900 - Aspergillus niger; uncharacterized protein 684029 4985619 An12g02680 Aspergillus niger uncharacterized protein XP_001395347.1 683472 D 5061 CDS An12g02690 84592505 complement(join(685227..685474,685525..685734,685780..685783)) III 1 NT_166527.1 Title: weak similarity to cytochrome b5 CB5 - Oryza sativa; See PMID 8049375; uncharacterized protein 685783 84592505 An12g02690 Aspergillus niger uncharacterized protein XP_059601822.1 685227 R 5061 CDS An12g02700 4985621 join(685908..686467,686532..686736) III 1 NT_166527.1 Catalytic activity: D-Gluconate + NAD+ or NADP+ = 5-Dehydro-D-gluconate + NADH or NADPH.; Remark: GNO is involved in the nonphosphorylative,ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate.; Remark: there is a great variety in the substrate specificity and cellular localizations in the short-chain alcohol dehydrogenase family.; Similarity: to members of the short-chain alcohol dehydrogenase family.; Title: strong similarity to gluconate 5-dehydrogenase GNO - Gluconobacter oxydans; See PMID 7981120; See PMID 7751271; uncharacterized protein 686736 4985621 An12g02700 Aspergillus niger uncharacterized protein XP_001395349.3 685908 D 5061 CDS An12g02710 84592506 complement(join(686813..686923,687012..687111,687183..687260,687357..687806,687875..688038,688281..688371,688464..688631,688714..688818,689383..689510)) III 1 NT_166527.1 Remark: CFP encodes a cercosporin transporter that contributes resistance to cercosporin by actively exporting cercosporin, thus maintaining low cellular concentrations of the toxin.; Remark: many species of the fungal genus Cercospora,including the soybean pathogen C. kikuchii, produce the phytotoxic polyketide cercosporin.; Remark: reduced expression of the membrane pump protein results in a reduction in cercosporin production,making the fungus less pathogenic to plants and also less able to protect itselt against cercosporin.; Remark: similarity to Cercospora kikuchii membrane pump protein patent WO9735001-A1.; Title: similarity to cercosporin transporter CFP -Cercospora kikuchii; See PMID 10517030; uncharacterized protein 689510 84592506 An12g02710 Aspergillus niger uncharacterized protein XP_059601823.1 686813 R 5061 CDS An12g02720 4985623 join(691662..691800,691873..692576) III 1 NT_166527.1 Remark: the sequence shows also similarity to the N-terminus of dihydrofolate reductases.; Title: similarity to hypothetical protein C25G4.2 -Caenorhabditis elegans; uncharacterized protein 692576 4985623 An12g02720 Aspergillus niger uncharacterized protein XP_001395351.1 691662 D 5061 CDS An12g02730 4985624 join(694901..695092,695175..695319,695395..695663,695729..696091,696158..697088,697142..702148,702215..702366) III 1 NT_166527.1 Remark: PKS1 is a multifunctional polyketide synthase (PKS)-encoding gene (PKS1) with six catalytic domains arranged in the following order, starting at the N terminus: beta-ketoacyl synthase, acyltransferase,dehydratase, enoyl reductase, beta-ketoacyl reductase, and acyl carrier protein.; Remark: the polyketide synthase is required for fungal virulence and production of the polyketide T-toxin.; Title: strong similarity to polyketide synthase PKS1 - Cochliobolus heterostrophus; See PMID 8953776; See PMID 10913297; uncharacterized protein 702366 4985624 An12g02730 Aspergillus niger uncharacterized protein XP_001395352.1 694901 D 5061 CDS An12g02740 4985625 complement(702901..703815) III 1 NT_166527.1 Remark: patent WO9743303-A1 and WO9737026-A1.; Title: weak similarity to ATP-dependent proteinase Clp from patent WO9743303-A1 - Streptococcus pneumoniae; uncharacterized protein 703815 4985625 An12g02740 Aspergillus niger uncharacterized protein XP_001395353.1 702901 R 5061 CDS An12g02750 4985626 complement(join(704290..705254,705314..707054,707098..707820)) III 1 NT_166527.1 Remark: due to its unusual lenght the protein could be a new polyketidesynthase.; Remark: similarity to polyketidsynthases.; Remark: similarity to the N-terminal region of acid-CoA ligases.; Title: similarity to FK520 biosynthetic gene cluster polyketide synthase fkbB - Streptomyces hygroscopicus; See PMID 9780228; See PMID 10863099; uncharacterized protein 707820 4985626 An12g02750 Aspergillus niger uncharacterized protein XP_059601824.1 704290 R 5061 CDS An12g02760 4985627 join(708901..709021,709092..709218,709273..709316,709382..709538,709755..709791,710231..710566) III 1 NT_166527.1 Title: similarity to hypothetical protein BAB49075.1 - Mesorhizobium loti; uncharacterized protein 710566 4985627 An12g02760 Aspergillus niger uncharacterized protein XP_001395355.3 708901 D 5061 CDS An12g02770 4985628 complement(710970..713183) III 1 NT_166527.1 Function: co-expression of het-e and het-c lead to cell death.; Function: het-e1 of P. anserina is responsible for vegetative incompatibility.; Remark: het-e1 of P. anserina shows also two sequence motifs, a GTP-binding domain and a repeated region that shares similarity with that of the beta-transducin.; Remark: only the N-terminal part shows similarity to het1-e1.; Remark: the C-terminal part shows similarity to ankyrin like proteins and death inducer proteins.; Remark: the reactivity of the HET-E protein depends on two functional elements, a GTP-binding domain and several WD40 repeats.; Title: similarity to beta transducin-like protein het-e1 - Podospora anserina; See PMID 9435787; See PMID 10875280; See PMID 10974123; See PMID 7557402; uncharacterized protein 713183 4985628 An12g02770 Aspergillus niger uncharacterized protein XP_001395356.1 710970 R 5061 CDS An12g02780 84592507 join(713922..715522,715669..715830,715890..715944) III 1 NT_166527.1 Remark: the sequence shows only with the N-terminal part similarity to AbsR1, but is 300 aa longer.; Title: strong similarity to hypothetical protein AAO55050.1 - Pseudomonas syringae; uncharacterized protein 715944 84592507 An12g02780 Aspergillus niger uncharacterized protein XP_059601825.1 713922 D 5061 CDS An12g02790 4985630 join(716291..716383,716441..717052,717128..717412) III 1 NT_166527.1 Catalytic activity: 3-(2-Hydroxyphenyl)propanoate + NAD+ = 2-Coumarate + NADH.; Pathway: phenylalanine metabolism.; Remark: PCBER is preferentially produced in the secondary xylem of stems and roots and is associated with the active growth period.; Remark: the enzyme is putative involved in lignan synthesis.; Title: strong similarity to phenylcoumaran benzylic ether reductase pcbera - Populus trichocarpa; See PMID 9664291; See PMID 11030549; uncharacterized protein 717412 4985630 An12g02790 Aspergillus niger uncharacterized protein XP_001395358.1 716291 D 5061 CDS An12g02800 4985631 join(717919..718606,718696..719038,719096..719351,719416..719745) III 1 NT_166527.1 Remark: TPO1 is a polyamine transport protein on the vacuolar membrane.; Similarity: to multidrug resistance proteins.; Title: strong similarity to polyamine transport protein Tpo1 - Saccharomyces cerevisiae; vacuole; See PMID 9678606; See PMID 9920864; uncharacterized protein 719745 4985631 An12g02800 Aspergillus niger uncharacterized protein XP_001395359.1 717919 D 5061 CDS An12g02810 4985632 join(720344..720505,720555..720696,720749..720875,720935..721700) III 1 NT_166527.1 Catalytic activity: S-Adenosyl-L-methionine + Sterigmatocystin = S-Adenosyl-L-homocysteine + 7-O-Methylsterigmatocystin.; Remark: RT-PCR data demonstrated that both the avfA and avfA1 as well as omtB genes in A. parasiticus were expressed only in the aflatoxin-conducive medium.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Remark: the biosynthesis of aflatoxins (B(1), G(1),B(2), and G(2)) is a multi-enzyme process controlled genetically by over 20 genes.; Title: strong similarity to O-methyltransferase omtB - Aspergillus flavus; See PMID 10328980; See PMID 10806361; uncharacterized protein 721700 4985632 An12g02810 Aspergillus niger uncharacterized protein XP_001395360.1 720344 D 5061 CDS An12g02820 4985633 complement(join(721798..722986,723038..723318)) III 1 NT_166527.1 Remark: azole resistance in Candida albicans can be mediated by several resistance mechanisms.; Remark: the fluconazole resistance protein seems N-and C-terminal longer.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353; See PMID 11181345; uncharacterized protein 723318 4985633 An12g02820 Aspergillus niger uncharacterized protein XP_001395361.1 721798 R 5061 CDS An12g02830 4985634 join(724425..724589,724647..724667,724720..724869,724921..725433) III 1 NT_166527.1 Title: weak similarity to hypothetical methyltransferase adpE - Anabaena sp.; See PMID 10931313; uncharacterized protein 725433 4985634 An12g02830 Aspergillus niger uncharacterized protein XP_001395362.1 724425 D 5061 CDS An12g02840 4985635 complement(join(725641..725934,725977..729057,729121..737283,737343..740561,740721..741128)) III 1 NT_166527.1 Remark: LPS1 activates the three amino acids of the peptide portion of ergot peptide alkaloids during D-lysergyl peptide assembly.; Title: strong similarity to d-lysergyl-peptide-synthase PS1 - Claviceps purpurea; See PMID 10071219; See PMID 1281482; uncharacterized protein 741128 4985635 An12g02840 Aspergillus niger uncharacterized protein XP_059601826.1 725641 R 5061 CDS An12g02850 4985636 join(741644..741802,741869..742711) III 1 NT_166527.1 Catalytic activity: NADPH + Oxidized thioredoxin = NADP+ + Reduced thioredoxin.; Pathway: pyrimidine metabolism; Remark: patent EP0565172-A/1.; Title: strong similarity to sulphydryl oxidase Sox from patent EP565172-A1 - Aspergillus niger; uncharacterized protein 742711 4985636 An12g02850 Aspergillus niger uncharacterized protein XP_001395364.1 741644 D 5061 CDS An12g02860 4985637 join(743319..743689,743767..744212,744275..744972) III 1 NT_166527.1 Similarity: to efflux pumps and resistance proteins.; Title: strong similarity to hypothetical protein of the lovastatin biosynthesis gene cluster - Aspergillus terreus; See PMID 10334994; uncharacterized protein 744972 4985637 An12g02860 Aspergillus niger uncharacterized protein XP_059601827.1 743319 D 5061 CDS An12g02870 84592508 join(745996..746238,746280..746393,746527..746653,746743..746783) III 1 NT_166527.1 hypothetical protein 746783 84592508 An12g02870 Aspergillus niger hypothetical protein XP_059601828.1 745996 D 5061 CDS An12g02880 4985639 complement(join(747014..747209,747265..747734,747797..748003,748056..748070,748123..748378,748434..748452,748527..748748,748804..748822,748880..749254,749311..749342,749479..749551)) III 1 NT_166527.1 Title: weak similarity to zinc binuclear cluster protein sequence #124 from patent WO200224865-A2 -Unclassified organism; uncharacterized protein 749551 4985639 An12g02880 Aspergillus niger uncharacterized protein XP_001395367.3 747014 R 5061 CDS An12g02890 4985640 complement(join(751532..751780,751887..752539,752609..752752,752833..752865,752934..752976)) III 1 NT_166527.1 Catalytic activity: L-Leucine + 2-Oxoglutarate = 4-Methyl-2-oxopentanoate + L-Glutamate.; Pathway: valine, leucine and isoleucine degradation; valine, leucine and isoleucine biosynthesis; pantothenate and CoA biosynthesis.; Remark: TOXF has a biosynthetic role in HC-toxin synthesis, perhaps to aminate a precursor of Aeo (2-amino-9, 10-epoxi-8-oxodecanoic acid).; Title: strong similarity to branched-chain amino acid aminotransferase TOXF - Cochliobolus carbonum; See PMID 10627051; uncharacterized protein 752976 4985640 An12g02890 Aspergillus niger uncharacterized protein XP_059601829.1 751532 R 5061 CDS An12g02900 4985641 complement(754176..755888) III 1 NT_166527.1 Function: het-6 of N. crassa is involved in the restriction of heterokaryon formation during asexual growth.; Remark: in filamentous fungi, vegetative cell fusion between genotypically distinct individuals leads to a cell-death reaction known as vegetative or heterokaryon incompatibility.; Similarity: het-6(OR) of N. crassa has three regions of amino acid sequence similarity to the predicted product of the het-e vegetative incompatibility gene in P. anserina and to the predicted product of tol, which mediates mating-type vegetative incompatibility in N. crassa.; Title: similarity to heterokaryon incompatibility protein het-6 - Neurospora crassa; See PMID 10880472; See PMID 11035941; See PMID 11092825; uncharacterized protein 755888 4985641 An12g02900 Aspergillus niger uncharacterized protein XP_059601830.1 754176 R 5061 CDS An12g02910 84592509 complement(join(756626..756684,756766..756814,756979..757320)) III 1 NT_166527.1 hypothetical protein 757320 84592509 An12g02910 Aspergillus niger hypothetical protein XP_059601831.1 756626 R 5061 CDS An12g02920 4985643 complement(join(759281..762001,762067..762180)) III 1 NT_166527.1 Similarity: the predicted ORF is 205 amino acids longer at the N-terminus than chiA of B. circulans; the similarity concerns the inner region of both proteins.; Title: weak similarity to chitinase A1 chiA -Bacillus circulans; See PMID 2203782; uncharacterized protein 762180 4985643 An12g02920 Aspergillus niger uncharacterized protein XP_001395371.3 759281 R 5061 CDS An12g02930 4985644 join(762815..763140,763203..763941) III 1 NT_166527.1 Title: weak similarity to ankyrin-related protein unc-44 - Caenorhabditis elegans; See PMID 7744957; uncharacterized protein 763941 4985644 An12g02930 Aspergillus niger uncharacterized protein XP_001395372.1 762815 D 5061 CDS An12g02940 84592510 join(765223..765363,765518..765626,765771..766558) III 1 NT_166527.1 hypothetical protein 766558 84592510 An12g02940 Aspergillus niger hypothetical protein XP_059601832.1 765223 D 5061 CDS An12g02950 4985646 join(767393..767439,767624..768033,768168..768640) III 1 NT_166527.1 Remark: the similarity is only in a small part of the ankyrins.; Title: weak similarity to 190 kDa ankyrin isoform AnkG190 - Rattus norvegicus; See PMID 9727010; uncharacterized protein 768640 4985646 An12g02950 Aspergillus niger uncharacterized protein XP_001395374.3 767393 D 5061 CDS An12g02960 4985647 complement(join(770004..771346,771377..771608)) III 1 NT_166527.1 hypothetical protein 771608 4985647 An12g02960 Aspergillus niger hypothetical protein XP_059601833.1 770004 R 5061 CDS An12g02970 4985648 complement(join(772138..772210,772264..772336,772395..772928,772988..773093,773157..773198,773250..773399)) III 1 NT_166527.1 Catalytic activity: a Phosphoprotein + H2O = a Protein + Orthophosphate.; Remark: protein phosphatase 2A (PP2A) comprises a family of serine/threonine phosphatases, minimally containing a well conserved catalytic subunit, the activity of which is highly regulated.; Remark: the use of specific PP2A inhibitors and molecular genetics in yeast, Drosophila and mice has revealed roles for PP2A in cell cycle regulation, cell morphology and development.; Title: strong similarity to phosphatase 2A ACP2 -Homo sapiens; See PMID 11171037; See PMID 2837763; uncharacterized protein 773399 4985648 An12g02970 Aspergillus niger uncharacterized protein XP_001395376.1 772138 R 5061 CDS An12g02980 4985649 join(773999..774178,774240..774641,774711..775010,775087..775155) III 1 NT_166527.1 Catalytic activity: a phosphoprotein + H2O = a protein + orthophosphate.; Remark: in A. nidulans, the temperature-sensitive,recessive cell cycle mutation bimG11 causes an elevated mitotic index at restrictive temperature and an inability to complete the anaphase separation of daughter nuclei.; Title: strong similarity to phosphoprotein phosphatase bimG - Aspergillus nidulans; See PMID 11104818; See PMID 2544297; uncharacterized protein 775155 4985649 An12g02980 Aspergillus niger uncharacterized protein XP_001395377.3 773999 D 5061 CDS An12g02990 4985650 complement(join(776913..777987,778052..778062)) III 1 NT_166527.1 Title: similarity to hypothetical protein encoded by An14g01970 - Aspergillus niger; uncharacterized protein 778062 4985650 An12g02990 Aspergillus niger uncharacterized protein XP_001395378.3 776913 R 5061 CDS An12g03010 4985651 complement(join(779162..779374,779426..779833)) III 1 NT_166527.1 Catalytic activity: Isochorismate + H2O = 2,3-Dihydro-2,3-dihydroxybenzoate + Pyruvate.; Pathway: ubiquinone biosynthesis; Remark: the cytosolic proteins EntE, EntF, and EntB/G, which are Escherichia coli enzymes necessary for the final stage of enterobactin synthesis, are released by osmotic shock.; Remark: the siderophore molecule enterobactin, a cyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)serine,is synthesized and secreted by Escherichia coli in response to iron starvation.; Title: similarity to isochorismatase entB -Escherichia coli; See PMID 9485415; See PMID 10692387; See PMID 2139796; uncharacterized protein 779833 4985651 An12g03010 Aspergillus niger uncharacterized protein XP_001395379.1 779162 R 5061 CDS An12g03020 4985652 join(780111..780246,780297..781690) III 1 NT_166527.1 Remark: shows also similarity to unknown geneproduct in the Aspergillus terreus lovastatin biosynthesis gene cluster.; Title: strong similarity to dityrosine transporter Dtr1 - Saccharomyces cerevisiae; See PMID 9678606; See PMID 10436161; uncharacterized protein 781690 4985652 An12g03020 Aspergillus niger uncharacterized protein XP_001395380.1 780111 D 5061 CDS An12g03030 84592511 complement(join(782776..783114,783244..783362,783442..783484)) III 1 NT_166527.1 hypothetical protein 783484 84592511 An12g03030 Aspergillus niger hypothetical protein XP_059601834.1 782776 R 5061 CDS An12g03040 4985654 complement(join(784555..785224,785379..785566,785690..785763,785805..785906,786210..786234,786374..786415)) III 1 NT_166527.1 Catalytic activity: Endonucleolytic cleavage to 5'-phosphomonoester.; Remark: acts on RNA-DNA hybrids. Similar enzymes are obtained from E. coli, chicken embryo, human KB cells, rat liver, Ustilago maydis, human leucaemic cells, S. cerevisiae (H2), and Tetrahymena.; Remark: also strong similarity to Human type 2 RNase H protein patent WO9928447-A1.; Title: similarity to ribonuclease H1 Rnh1 - Mus musculus; See PMID 9181574; See PMID 9799596; uncharacterized protein 786415 4985654 An12g03040 Aspergillus niger uncharacterized protein XP_001395382.3 784555 R 5061 CDS An12g03050 4985655 join(788840..789309,789387..789666) III 1 NT_166527.1 Title: strong similarity to hypothetical protein encoded by An11g05880 - Aspergillus niger; uncharacterized protein 789666 4985655 An12g03050 Aspergillus niger uncharacterized protein XP_001395383.1 788840 D 5061 CDS An12g03070 4985657 complement(join(790730..790892,790977..791005,791077..791214,791321..791385,791439..792807,792871..793191)) III 1 NT_166527.1 Title: strong similarity to hypothetical protein SPAC4H3.03c - Schizosaccharomyces pombe; uncharacterized protein 793191 4985657 An12g03070 Aspergillus niger uncharacterized protein XP_059601835.1 790730 R 5061 CDS An12g03080 84592512 join(793727..793735,793991..794113) III 1 NT_166527.1 hypothetical protein 794113 84592512 An12g03080 Aspergillus niger hypothetical protein XP_059601836.1 793727 D 5061 CDS An12g03090 84592513 join(794829..795385,795422..795464) III 1 NT_166527.1 hypothetical protein 795464 84592513 An12g03090 Aspergillus niger hypothetical protein XP_059601837.1 794829 D 5061 CDS An12g03100 84592514 complement(796037..>797260) III 1 NT_166527.1 Remark: the ORF encoded protein ist N-terminally truncated due to contig boundary.; Title: strong similarity to hypothetical protein CAD71224.1 - Neurospora crassa [truncated ORF]; uncharacterized protein 797260 84592514 An12g03100 Aspergillus niger uncharacterized protein XP_059601838.1 796037 R 5061 CDS An12g03110 4985661 join(<797362..797391,797456..797636,797691..798427) III 1 NT_166527.1 Function: the membrane pump protein of C. kikuchii confers resistance to the polyketide phytotoxin cercosporin.; Title: strong similarity to membrane pump protein from patent WO9735001-A1 - Cercospora kikuchii [truncated ORF]; plasma membrane; See PMID 10517030; uncharacterized protein 798427 4985661 An12g03110 Aspergillus niger uncharacterized protein XP_001395388.3 797362 D 5061 CDS An12g03120 4985662 complement(join(798550..798579,798680..799582)) III 1 NT_166527.1 Function: lipP of Pseudomonas sp. shows 1,3-positional specificity towards triolein.; Function: lipP of Pseudomonas sp. shows high activity towards short-chain to medium-chain fatty acids.; Similarity: lipP of Pseudomonas sp. belongs to the 'gdxg' family of lipolytic enzymes.; Title: strong similarity to lipase LipP -Pseudomonas sp.; See PMID 9464382; uncharacterized protein 799582 4985662 An12g03120 Aspergillus niger uncharacterized protein XP_001395389.3 798550 R 5061 CDS An12g03130 4985663 join(800927..801016,801149..801796) III 1 NT_166527.1 Remark: the similarity of the ORF encoded protein is only based on repetitive amino acids.; hypothetical protein 801796 4985663 An12g03130 Aspergillus niger hypothetical protein XP_001395390.3 800927 D 5061 CDS An12g03140 4985664 join(802508..802644,802711..804004) III 1 NT_166527.1 Remark: the homology is mainly based on repetitiv amino acids.; Title: weak similarity to hypothetical megakaryocyte stimulating factor - Mus musculus; uncharacterized protein 804004 4985664 An12g03140 Aspergillus niger uncharacterized protein XP_001395391.1 802508 D 5061 CDS An12g03150 4985665 complement(join(804919..804945,804999..805971,806023..806552,806602..806884,806904..807394,807440..808034,808081..808682,808734..808788,808853..808968,809022..809309)) III 1 NT_166527.1 Phenotype: Delta atrD mutants in A. nidulans display a hypersensitive phenotype to compounds such as cycloheximide, the cyclosporin derivative PSC 833,nigericin and valinomycin, indicating that AtrDp is involved in protection against cytotoxic compounds.; Similarity: atrD of A. nidulans shows similarity to the ATP-binding transport protein family (ABC transporters).; Title: strong similarity to multidrug resistance protein atrD - Aspergillus nidulans; plasma membrane; See PMID 10954082; uncharacterized protein 809309 4985665 An12g03150 Aspergillus niger uncharacterized protein XP_059604376.1 804919 R 5061 CDS An12g03160 4985666 join(810175..810465,810539..810871,810927..811412,811467..811684,811747..811966) III 1 NT_166527.1 Remark: a splice site was detected upstream of the START codon.; hypothetical protein 811966 4985666 An12g03160 Aspergillus niger hypothetical protein XP_059604377.1 810175 D 5061 CDS An12g03170 4985667 join(812526..812614,812683..814373,814442..814645,814715..814914) III 1 NT_166527.1 Function: facB of A. nidulans encodes a Zn(II)2Cys6 transcriptional activator.; Phenotype: facB recessive loss of function mutants in A. nidulans are deficient in acetate induction of acetyl-CoA synthase, isocitrate lyase, malate synthase,acetamidase, and NADP-isocitrate dehydrogenase.; Title: strong similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; nucleus; See PMID 9197408; See PMID 9367656; uncharacterized protein 814914 4985667 An12g03170 Aspergillus niger uncharacterized protein XP_001395394.3 812526 D 5061 CDS An12g03180 4985668 complement(join(815344..815934,815991..816442,816549..816694,816752..816848,816906..816948)) III 1 NT_166527.1 Catalytic activity: salicylate + NADH + O(2) = catechol + NAD(+) + H(2)O + CO(2).; Pathway: nahpthalene catabolism and phenylalanine metabolism.; Title: strong similarity to salicylate hydroxylase nahG - Pseudomonas putida; See PMID 1993181; See PMID 2363715; uncharacterized protein 816948 4985668 An12g03180 Aspergillus niger uncharacterized protein XP_059604378.1 815344 R 5061 CDS An12g03190 4985669 join(817305..817571,817634..817806,817871..817980,818022..818164,818197..818319) III 1 NT_166527.1 Title: strong similarity to hypothetical protein YAL049c - Saccharomyces cerevisiae; uncharacterized protein 818319 4985669 An12g03190 Aspergillus niger uncharacterized protein XP_059604379.1 817305 D 5061 CDS An12g03200 10098111 complement(join(819204..819587,819644..820277,820588..820641,820711..821117,821278..821450,821502..821691,821749..822234,822340..822345)) III 1 NT_166527.1 Function: human actVA-ORF4-like protein is useful in the treatment of infectious, vesicle trafficking,immunological and neoplastic disorders.; Remark: the ORF encoded protein also shows weak similarity to several transkription factors.; Title: similarity to actVA-ORF4-like protein from patent WO9911793-A1 - Homo sapiens; uncharacterized protein 822345 10098111 An12g03200 Aspergillus niger uncharacterized protein XP_059604380.1 819204 R 5061 CDS An12g03210 4985671 join(822908..822944,823041..823533,823609..823708,823763..823822,823881..823964) III 1 NT_166527.1 Function: the nor-1 gene is involved in aflatoxin biosynthesis in Aspergillus parasiticus. Recombinant Nor-1 expressed in Escherichia coli converted the 1' keto group of norsolorinic acid to the 1' hydroxyl group of averantin in crude E. coli cell extracts in the presence of NADPH.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins. athway: nor-1 of A. parasiticus is involved in the aflatoxin biosynthesis.; Remark: nar-1 is an alternative name for nor-1.; Similarity: nor-1 of A. parasiticus belongs to the short-chain dehydrogenases/reductases (sdr) family.; Title: strong similarity to norsolorinic acid ketoreductase nor-1 - Aspergillus parasiticus; See PMID 7993094; uncharacterized protein 823964 4985671 An12g03210 Aspergillus niger uncharacterized protein XP_001395398.3 822908 D 5061 CDS An12g03220 4985672 complement(join(824637..824968,825024..825135)) III 1 NT_166527.1 Title: similarity to hypothetical protein encoded by slr0318 - Synechocystis sp; uncharacterized protein 825135 4985672 An12g03220 Aspergillus niger uncharacterized protein XP_001395399.1 824637 R 5061 CDS An12g03230 4985673 join(825364..825499,825569..825872,825922..>827616) III 1 NT_166527.1 Catalytic activity: l-serine + 1-(indol-3-yl)glycerol 3-phosphate = l-tryptophan + glyceraldehyde 3-phosphate + H(2)O.; Pathway: last (fifth) step in biosynthesis of tryptophan.; Remark: a putative sequencing error results in an frameshift.; Title: strong similarity to tryptophan synthase-encoding trpB - Aspergillus nidulans [putative frameshift]; putative frameshift; See PMID 10905354; uncharacterized protein 827616 4985673 An12g03230 Aspergillus niger uncharacterized protein XP_059604381.1 825364 D 5061 CDS An12g03240 4985674 complement(join(828655..829113,829229..829274,829335..829765)) III 1 NT_166527.1 Catalytic activity: acetyl-CoA + arylamine = CoA + N-acetylarylamine.; Remark: pineal gland isozyme NAT-10 and arylamine acetylase are alternative names for arylamine N-acetyltransferase.; Similarity: belongs to the arylamine N-acetyltransferase family.; Title: similarity to arylamine N-acetyltransferase -Gallus gallus; See PMID 2583181; uncharacterized protein 829765 4985674 An12g03240 Aspergillus niger uncharacterized protein XP_059604382.1 828655 R 5061 CDS An12g03250 4985675 complement(830631..832373) III 1 NT_166527.1 Title: similarity to immunogenic protein #5097 from patent WO200181581-A2 - Propionibacterium acnes; uncharacterized protein 832373 4985675 An12g03250 Aspergillus niger uncharacterized protein XP_001395402.1 830631 R 5061 CDS An12g03260 4985676 join(832790..833050,833112..833804) III 1 NT_166527.1 Catalytic activity: (3S)-3-Hydroxyacyl-CoA + NAD+ = 3-Oxoacyl-CoA + NADH.; Title: strong similarity to 3-hydroxyacyl-CoA dehydrogenase hmgA - Sulfolobus solfataricus; See PMID 9171410; uncharacterized protein 833804 4985676 An12g03260 Aspergillus niger uncharacterized protein XP_001395403.1 832790 D 5061 CDS An12g03270 4985677 join(834563..834596,834643..834752,834813..835700) III 1 NT_166527.1 Title: similarity to hypothetical BH0305 - Bacillus halodurans; uncharacterized protein 835700 4985677 An12g03270 Aspergillus niger uncharacterized protein XP_001395404.3 834563 D 5061 CDS An12g03280 4985678 complement(join(836489..836624,836707..837147,837231..837370,837460..837496,837571..837768,837866..837971,838018..838308,838357..838772,838925..839013,839145..839265,839346..839448,839635..839715,839956..840093,840170..840203)) III 1 NT_166527.1 hypothetical protein 840203 4985678 An12g03280 Aspergillus niger hypothetical protein XP_059604383.1 836489 R 5061 CDS An12g03290 4985679 join(841414..841597,841651..841733,841790..843010) III 1 NT_166527.1 Catalytic activity: catalyzes the conversion of RCH2NH2 + H2O + O2 = RCHO + NH3 + H2O2.; Gene-ID: maoN; monoamine oxidase maoN-Aspergillus niger 843010 maoN 4985679 maoN Aspergillus niger monoamine oxidase maoN-Aspergillus niger XP_001395406.1 841414 D 5061 CDS An12g03300 4985680 complement(join(843111..843494,843544..843859,843910..844565)) III 1 NT_166527.1 Title: strong similarity to aspartic protease pr1 -Phaffia rhodozyma; extracellular/secretion proteins; uncharacterized protein 844565 4985680 An12g03300 Aspergillus niger uncharacterized protein XP_001395407.1 843111 R 5061 CDS An12g03310 84592515 join(845931..846021,846126..847389,847476..847534,847875..847985,848137..848310,848386..848436,848591..848737,848834..848892,849053..849174,849259..849375,849530..849586,849895..849992,850100..850171,850302..850387) III 1 NT_166527.1 hypothetical protein 850387 84592515 An12g03310 Aspergillus niger hypothetical protein XP_059604384.1 845931 D 5061 CDS An12g03320 84592516 complement(join(850970..851347,851415..851561,852106..852223,852305..852388,852485..852512,852659..852773,852851..852877,852987..853070,853118..853214,853300..853517,853606..853679,853990..854085,854203..854271,854376..854424,855322..855451,855579..855696,855804..856001,856105..856363)) III 1 NT_166527.1 hypothetical protein 856363 84592516 An12g03320 Aspergillus niger hypothetical protein XP_059604385.1 850970 R 5061 CDS An12g03330 84592517 complement(join(856849..857169,857589..857728,858576..858676,858719..860394)) III 1 NT_166527.1 Remark: blast matches are random.; Title: weak similarity to protein-tyrosine-phosphatase ptp-bk - Mus musculus; uncharacterized protein 860394 84592517 An12g03330 Aspergillus niger uncharacterized protein XP_059604386.1 856849 R 5061 CDS An12g03340 84592518 complement(join(861281..861375,861563..862319)) III 1 NT_166527.1 hypothetical protein 862319 84592518 An12g03340 Aspergillus niger hypothetical protein XP_059604387.1 861281 R 5061 CDS An12g03350 84592519 join(862584..862720,862830..862911,863003..863064,863155..863450,863502..863590,863675..863855,864332..864405,864476..864734,864823..864900,865001..865074,865329..865396,865488..865643,865750..865960,866039..866260) III 1 NT_166527.1 Title: weak similarity to hypothetical protein encoded by An08g04870 - Aspergillus niger; uncharacterized protein 866260 84592519 An12g03350 Aspergillus niger uncharacterized protein XP_059604388.1 862584 D 5061 CDS An12g03360 84592520 complement(join(866377..866622,866850..866962,867176..867250,867384..867639)) III 1 NT_166527.1 hypothetical protein 867639 84592520 An12g03360 Aspergillus niger hypothetical protein XP_059604389.1 866377 R 5061 CDS An12g03370 4985687 join(868134..868194,868277..868492,868536..870229,870267..870455) III 1 NT_166527.1 Title: similarity to protein fragment SEQ ID NO:37063 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 870455 4985687 An12g03370 Aspergillus niger uncharacterized protein XP_059604390.1 868134 D 5061 CDS An12g03380 84592521 complement(join(871946..872153,872216..872882,872956..873061)) III 1 NT_166527.1 Title: weak similarity to transcription factor BKLF - Mus musculus; uncharacterized protein 873061 84592521 An12g03380 Aspergillus niger uncharacterized protein XP_059604391.1 871946 R 5061 CDS An12g03390 84592522 complement(join(873535..873649,874545..874606,874681..874900,875325..875426,875456..876070,876211..876281)) III 1 NT_166527.1 hypothetical protein 876281 84592522 An12g03390 Aspergillus niger hypothetical protein XP_059604392.1 873535 R 5061 CDS An12g03400 84592523 complement(join(877986..878196,878261..878691)) III 1 NT_166527.1 Title: weak similarity to transcription factor MHY1 - Yarrowia lipolytica; uncharacterized protein 878691 84592523 An12g03400 Aspergillus niger uncharacterized protein XP_059604393.1 877986 R 5061 CDS An12g03410 84592524 join(880387..880535,880609..880696) III 1 NT_166527.1 hypothetical protein 880696 84592524 An12g03410 Aspergillus niger hypothetical protein XP_059604394.1 880387 D 5061 CDS An12g03420 84592525 complement(join(881438..881555,881699..881784,881836..881944,882036..882273,882351..882565,882945..883058,883280..883624,883839..883879)) III 1 NT_166527.1 Similarity: shows similarity to N-terminal part of gap of M. hominis.; Title: weak similarity to glyceraldehyde 3-phosphate dehydrogenase gap - Mycoplasma hominis; uncharacterized protein 883879 84592525 An12g03420 Aspergillus niger uncharacterized protein XP_059604395.1 881438 R 5061 CDS An12g03440 4985693 complement(884113..886080) III 1 NT_166527.1 Catalytic activity: glucose oxidase catalyzes the conversion of Beta-D-glucose + O(2) <=> D-glucono-1,5-lactone + H(2)O(2).; Title: similarity to glucose oxidase goxC -Aspergillus niger; uncharacterized protein 886080 4985693 An12g03440 Aspergillus niger uncharacterized protein XP_001395420.1 884113 R 5061 CDS An12g03460 4985695 complement(886991..888328) III 1 NT_166527.1 Title: strong similarity to proline permease prnB -Aspergillus nidulans; plasma membrane; See PMID 9140969; See PMID 10613888; See PMID 8437566; uncharacterized protein 888328 4985695 An12g03460 Aspergillus niger uncharacterized protein XP_001395421.3 886991 R 5061 CDS An12g03470 84592526 complement(join(888805..889011,889227..889265,889369..889401,889465..889584,889659..889748)) III 1 NT_166527.1 hypothetical protein 889748 84592526 An12g03470 Aspergillus niger hypothetical protein XP_059604396.1 888805 R 5061 CDS An12g03480 84592527 join(890170..890271,890539..890606,890966..891064,891556..891633,891681..891747) III 1 NT_166527.1 Title: weak similarity to hypothetical protein encoded by An12g03490 - Aspergillus niger; uncharacterized protein 891747 84592527 An12g03480 Aspergillus niger uncharacterized protein XP_059604397.1 890170 D 5061 CDS An12g03490 84592528 join(891799..891862,891947..892049,892340..892413,892616..892696,892744..892804,892876..892959,893144..893168,893271..893367,893417..893550,893592..893761,893945..894031,894127..894165,894261..894425,894526..894583,894682..894827,894919..894996,895099..895141) III 1 NT_166527.1 Title: weak similarity to hypothetical protein encoded by An12g03480 - Aspergillus niger; uncharacterized protein 895141 84592528 An12g03490 Aspergillus niger uncharacterized protein XP_059604398.1 891799 D 5061 CDS An12g03500 4985699 complement(join(896437..896852,896923..897173,897242..897288)) III 1 NT_166527.1 Title: weak similarity to hypothetical protein CAD71089.1 - Neurospora crassa; uncharacterized protein 897288 4985699 An12g03500 Aspergillus niger uncharacterized protein XP_001395425.3 896437 R 5061 CDS An12g03510 84592529 complement(898334..899758) III 1 NT_166527.1 Title: strong similarity to hypothetical protein encoded by An15g07630 - Aspergillus niger; uncharacterized protein 899758 84592529 An12g03510 Aspergillus niger uncharacterized protein XP_059604399.1 898334 R 5061 CDS An12g03520 84592530 complement(899903..900049) III 1 NT_166527.1 hypothetical protein 900049 84592530 An12g03520 Aspergillus niger hypothetical protein XP_059604400.1 899903 R 5061 CDS An12g03530 4985702 complement(join(<900814..900988,901063..901229,901296..901403,901472..901513,901518..902325,902380..902575)) III 1 NT_166527.1 Function: cytochrome P450s are involved in the oxidative degradation of various compounds.; Function: the cytochrome P450 enzymes usually act as terminal oxidases in multicomponent electron transfer chains, called P450-containing monooxygenase systems.; Remark: a putative sequencing error results in an frameshift.; Title: similarity to cytochrome P450 trichodiene oxygenase TRI4 - Fusarium sporotrichioides [putative frameshift]; putative frameshift; uncharacterized protein 902575 4985702 An12g03530 Aspergillus niger uncharacterized protein XP_059604401.1 900814 R 5061 CDS An12g03540 84592531 complement(902794..903177) III 1 NT_166527.1 hypothetical protein 903177 84592531 An12g03540 Aspergillus niger hypothetical protein XP_059604402.1 902794 R 5061 CDS An12g03550 4985704 complement(join(904174..904358,904419..904767,904818..905237,905295..905355,905415..905559,905619..905714,905765..906014)) III 1 NT_166527.1 Remark: the systematic genename of S. cerevisiae DAL5 is YJR152W.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 10869563; See PMID 3301804; uncharacterized protein 906014 4985704 An12g03550 Aspergillus niger uncharacterized protein XP_001395430.3 904174 R 5061 CDS An12g03560 84592532 join(906319..906369,906438..906495,906575..906720) III 1 NT_166527.1 hypothetical protein 906720 84592532 An12g03560 Aspergillus niger hypothetical protein XP_059604403.1 906319 D 5061 CDS An12g03570 4985706 complement(join(907133..907818,907888..908044)) III 1 NT_166527.1 Catalytic activity: catalyzes the conversion of orotidine-5'-phosphate = UMP + CO2.; Gene-ID: pyrA;pyrG; Mapping: pyrA/pyrG from A. niger is mapped to chromosome III; see list from DSM, EMBL X96734.; Pathway: sixth and last step in the biosynthesis of pyrimidines.; Remark: pyrA ang pyrG from A. niger are probable identical.; Similarity: belongs to the omp decarboxylase family.; See PMID 8650301; See PMID 3357784; orotidine-5-phosphate decarboxylase pyrA-Aspergillus niger 908044 pyrA 4985706 pyrA Aspergillus niger orotidine-5-phosphate decarboxylase pyrA-Aspergillus niger XP_001395432.1 907133 R 5061 CDS An12g03580 4985707 complement(join(908566..908856,908916..909051,909126..909157)) III 1 NT_166527.1 Catalytic activity: glutathione S-transferases catalyze the conversion of RX + glutathione <=> HX + R-S-glutathione.; Title: strong similarity to microsomal glutathione S-transferase 3 MGST3 - Homo sapiens; uncharacterized protein 909157 4985707 An12g03580 Aspergillus niger uncharacterized protein XP_001395433.1 908566 R 5061 CDS An12g03590 84592533 join(909159..909211,909256..909421) III 1 NT_166527.1 hypothetical protein 909421 84592533 An12g03590 Aspergillus niger hypothetical protein XP_059604404.1 909159 D 5061 CDS An12g03600 4985709 complement(join(909555..909754,909804..910761,910867..910978,911022..911122)) III 1 NT_166527.1 Catalytic activity: diacylglycerol acyltransferases catalyze the conversion of acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.; EC:2.3.1.20; Function: diacylglycerol acyltransferase DAGAT of A. thaliana catalyzes the acylation of diacylglycerol by oleoylcoA to give triacylglycerol.; Remark: might alternatively be a sterol O-acyltransferase.; Title: strong similarity to diacylglycerol acyltransferase DAGAT - Arabidopsis thaliana; See PMID 10601854; uncharacterized protein 911122 4985709 An12g03600 Aspergillus niger uncharacterized protein XP_059604405.1 909555 R 5061 CDS An12g03610 84592534 join(911164..911238,911378..911476,911571..911843) III 1 NT_166527.1 hypothetical protein 911843 84592534 An12g03610 Aspergillus niger hypothetical protein XP_059604406.1 911164 D 5061 CDS An12g03620 4985711 join(911924..912017,912112..912227,912301..912501,912565..>913167) III 1 NT_166527.1 Function: Pfs2p of S. cerevisiae is required for mRNA 3'-end processing, it bridges two mRNA 3'-end processing factors.; Remark: the systematic genename of PFS2 of S. cerevisiae is YNL317w.; Remark: truncated ORF due to end of contig.; Title: similarity to polyadenylation factor I subunit 2 Pfs2 - Saccharomyces cerevisiae [truncated ORF]; See PMID 10619842; uncharacterized protein 913167 4985711 An12g03620 Aspergillus niger uncharacterized protein XP_059604407.1 911924 D 5061 CDS An12g03640 84592535 join(<913296..913689,913740..913927) III 1 NT_166527.1 Remark: truncated ORF due to end of contig.; hypothetical protein [truncated ORF] 913927 84592535 An12g03640 Aspergillus niger hypothetical protein [truncated ORF] XP_059604408.1 913296 D 5061 CDS An12g03630 4985713 complement(join(913968..914088,914146..914435)) III 1 NT_166527.1 Title: similarity to hypothetical membrane protein YPR153w - Saccharomyces cerevisiae; uncharacterized protein 914435 4985713 An12g03630 Aspergillus niger uncharacterized protein XP_001395439.1 913968 R 5061 CDS An12g03650 4985714 join(914774..914847,914910..916356,916410..916631,916702..916995) III 1 NT_166527.1 Remark: PEX17 is required for the import of a subset of matrix proteins into peroxisomes in Yarrowia lipolytica.; Title: similarity to peroxisomal membrane protein PEX17 - Yarrowia lipolytica; peroxisome; See PMID 9111320; uncharacterized protein 916995 4985714 An12g03650 Aspergillus niger uncharacterized protein XP_059604409.1 914774 D 5061 CDS An12g03660 4985715 complement(join(917236..917324,917388..918138)) III 1 NT_166527.1 Catalytic activity: S-adenosyl-L-methionine + protein S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.; EC:2.1.1.100; Remark: STE14 mediates C-terminal methylation of the isoprenylated C-terminal cysteine in a-factor mating pheromone and RAS-proteins in S. cerevisiae.; Remark: STE14 null mutant exhibits a profound block in a-factor export in S. cerevisiae.; Title: strong similarity to farnesyl cysteine carboxyl-methyltransferase Ste14 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 8212897; uncharacterized protein 918138 4985715 An12g03660 Aspergillus niger uncharacterized protein XP_001395441.1 917236 R 5061 CDS An12g03670 4985716 join(918845..919005,919158..919518,919604..919681) III 1 NT_166527.1 EC:2.3.1.-; Function: maltose O-acetyltransferase mac of E. coli acetylates glucose, maltose, mannose, galactose and fructose in Escherichia coli.; Function: putative O-acetyltransferase.; Title: strong similarity to maltose O-acetyltransferase maa - Escherichia coli; See PMID 1856235; uncharacterized protein 919681 4985716 An12g03670 Aspergillus niger uncharacterized protein XP_059604410.1 918845 D 5061 CDS An12g03680 84592536 join(920027..920234,920311..920397,920521..920615,920713..920802) III 1 NT_166527.1 Protein sequence is in conflict with the conceptual translation; putative sequencing error; hypothetical protein [putative sequencing error] 920802 84592536 An12g03680 Aspergillus niger hypothetical protein [putative sequencing error] XP_059604411.1 920027 D 5061 CDS An12g03690 84592537 complement(join(921297..921396,921469..921548)) III 1 NT_166527.1 hypothetical protein 921548 84592537 An12g03690 Aspergillus niger hypothetical protein XP_059604412.1 921297 R 5061 CDS An12g03700 4985719 join(921695..922557,922648..925381,925481..925609,925663..926409,926459..926562,926611..926810,926888..927451,927511..929646,929703..929759,929861..929913,930016..930087,930177..930254) III 1 NT_166527.1 Function: Ubiquitin-specific proteases (UBPs) are a family of unique hydrolases that specifically remove polypeptides covalently linked via peptide or isopeptide bonds to the C-terminal glycine of ubiquitin.; Title: strong similarity to ubiquitin specific protease UBP12 - Arabidopsis thaliana; See PMID 11115897; uncharacterized protein 930254 4985719 An12g03700 Aspergillus niger uncharacterized protein XP_059604413.1 921695 D 5061 CDS An12g03710 4985720 complement(join(931610..932780,932857..932952,933018..933112)) III 1 NT_166527.1 Title: strong similarity to alpha subunit of transcription initiation factor TFIIE Tfa1 - Saccharomyces cerevisiae; nucleus; See PMID 7961670; uncharacterized protein 933112 4985720 An12g03710 Aspergillus niger uncharacterized protein XP_001395446.1 931610 R 5061 CDS An12g03720 4985721 join(933559..933785,933883..934065,934130..934583,934707..935337,935415..>935625) III 1 NT_166527.1 Catalytic activity: tRNA-pseudouridine synthase catalyzes the conversion of tRNA uridine to tRNA pseudouridine.; Remark: Pus1p in S. cerevisiae is an intranuclear protein which exhibits a nucleotide-specific and intron-dependent tRNA pseudouridine synthase activity.; Remark: possible sequencing error at position 28835; 2 bp too much.; Title: strong similarity to tRNA-pseudouridine synthase I Pus1 - Saccharomyces cerevisiae [putative frameshift]; nucleus; putative frameshift; See PMID 8641292; uncharacterized protein 935625 4985721 An12g03720 Aspergillus niger uncharacterized protein XP_059604414.1 933559 D 5061 CDS An12g03730 4985722 complement(join(936010..936602,936633..936971,937004..937252,937376..937598)) III 1 NT_166527.1 Function: Sen1 of S. cerevisiae is involved in tRNA processing.; Similarity: the ORF is shorter than Sen1 of S. cerevisiae and the homology between the two proteins is restricted to a stretch of about 300 amino acids.; Title: similarity to ATP dependent RNA helicase Sen1 - Saccharomyces cerevisiae; See PMID 8544822; See PMID 9365256; See PMID 9819377; See PMID 1569945; uncharacterized protein 937598 4985722 An12g03730 Aspergillus niger uncharacterized protein XP_059604415.1 936010 R 5061 CDS An12g03740 84592538 complement(join(938109..938333,938445..938809,938901..939129,939279..939326,939502..939663)) III 1 NT_166527.1 Remark: the ORF has an unusual exon/intron structure for A. niger.; Title: weak similarity to hypothetical protein encoded by An12g03800 - Aspergillus niger; uncharacterized protein 939663 84592538 An12g03740 Aspergillus niger uncharacterized protein XP_059604416.1 938109 R 5061 CDS An12g03750 84592539 complement(join(939838..939957,940190..940286,940368..940438,940531..940590,940650..940754)) III 1 NT_166527.1 Remark: the ORF has an unusual exon/intron structure for A. niger.; hypothetical protein 940754 84592539 An12g03750 Aspergillus niger hypothetical protein XP_059604417.1 939838 R 5061 CDS An12g03760 4985725 complement(join(940964..941016,941097..941124,941260..941477,941545..941611,941724..942001,942222..942339,942389..942796)) III 1 NT_166527.1 Title: similarity to hypothetical protein encoded by An12g03780 - Aspergillus niger; uncharacterized protein 942796 4985725 An12g03760 Aspergillus niger uncharacterized protein XP_059604418.1 940964 R 5061 CDS An12g03770 4985726 complement(join(943440..943497,943632..943722,943847..943936,944008..944056,944121..944317,944384..944450,944510..944773,944839..944924,944979..945042,945121..945489)) III 1 NT_166527.1 Title: similarity to hypothetical protein encoded by An12g03780 - Aspergillus niger; uncharacterized protein 945489 4985726 An12g03770 Aspergillus niger uncharacterized protein XP_001395452.3 943440 R 5061 CDS An12g03780 4985727 join(945519..945608,945756..946074,946280..946650,946934..947275,947353..947419,947475..947692,947761..947862) III 1 NT_166527.1 Similarity: shows also weak similarity to vimentin and myosin of different organisms.; Title: weak similarity to hypothetical methyl-accepting chemotaxis related protein PAB1308 -Pyrococcus abyssi; uncharacterized protein 947862 4985727 An12g03780 Aspergillus niger uncharacterized protein XP_059604419.1 945519 D 5061 CDS An12g03790 84592540 complement(join(947887..947970,948470..948725,948784..948899)) III 1 NT_166527.1 Title: weak similarity to elongation factor Ts tsf -Guillardia theta; uncharacterized protein 948899 84592540 An12g03790 Aspergillus niger uncharacterized protein XP_059604420.1 947887 R 5061 CDS An12g03800 84592541 complement(join(949087..949317,949423..949519,949730..949932,950307..950672)) III 1 NT_166527.1 Remark: the ORF has an unusual exon/intron structure for A. niger.; Title: weak similarity to hypothetical protein encoded by An12g03740 - Aspergillus niger; uncharacterized protein 950672 84592541 An12g03800 Aspergillus niger uncharacterized protein XP_059604421.1 949087 R 5061 CDS An12g03810 84592542 complement(join(951262..951390,951449..951565)) III 1 NT_166527.1 Remark: the ORF is short in sequence.; hypothetical protein 951565 84592542 An12g03810 Aspergillus niger hypothetical protein XP_059604422.1 951262 R 5061 CDS An12g03820 84592543 complement(join(952300..952503,952704..952793)) III 1 NT_166527.1 hypothetical protein 952793 84592543 An12g03820 Aspergillus niger hypothetical protein XP_059604423.1 952300 R 5061 CDS An12g03830 4985732 complement(join(953244..953816,953872..954575,954631..957403)) III 1 NT_166527.1 Function: alpha INT1 of C. albicans mediates enhanced aggregation/adhesion and plays a role in morphogenesis.; Similarity: the ORF is shorter than alpha INT1 of C. albicans (1349 compared to 1664 amino acids) and the homology between the two proteins is restricted to a central stretch of about 400 amino acids.; Title: similarity to integrin-like protein alpha chain alpha INT1 - Candida albicans; See PMID 8552638; uncharacterized protein 957403 4985732 An12g03830 Aspergillus niger uncharacterized protein XP_001395458.3 953244 R 5061 CDS An12g03840 84592544 complement(957990..958652) III 1 NT_166527.1 hypothetical protein 958652 84592544 An12g03840 Aspergillus niger hypothetical protein XP_059604424.1 957990 R 5061 CDS An12g03850 4985734 join(958723..959364,959464..>960553) III 1 NT_166527.1 Function: CHR1 of C. albicans complements a rok1 mutant of S. cerevisiae which is required for cell cycle progression and also for rRNA processing.; Remark: a putative sequencing error results in an frameshift.; Title: similarity to DEAD box RNA helicase CHR1 -Candida albicans [putative frameshift]; nucleus; putative frameshift; See PMID 10705369; uncharacterized protein 960553 4985734 An12g03850 Aspergillus niger uncharacterized protein XP_059604425.1 958723 D 5061 CDS An12g03860 84592545 complement(join(<960905..961162,961250..962601)) III 1 NT_166527.1 EC:3.1.1.-; Function: putative carboxylic esterase.; Remark: possible sequencing error at position 1047,2 bp too much.; Similarity: shows similarity to several kinds of different esterases, e. g. acetylcholinesterases,triacylglycerol lipases.; Title: strong similarity to precursor of cephalosporin esterase - Rhodosporidium toruloides [putative frameshift]; putative frameshift; See PMID 9406399; uncharacterized protein 962601 84592545 An12g03860 Aspergillus niger uncharacterized protein XP_059604426.1 960905 R 5061 CDS An12g03880 4985736 complement(join(963279..965075,965138..965248)) III 1 NT_166527.1 Title: similarity to hypothetical protein SPCC4B3.12 - Schizosaccharomyces pombe; uncharacterized protein 965248 4985736 An12g03880 Aspergillus niger uncharacterized protein XP_001395462.1 963279 R 5061 CDS An12g03890 4985737 join(965747..965761,965837..965921,965994..966218,966288..966358) III 1 NT_166527.1 Title: strong similarity to mitochondrial ribosomal protein of the large subunit L14 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 2060626; mitochondrial 54S ribosomal protein uL14m 966358 4985737 An12g03890 Aspergillus niger mitochondrial 54S ribosomal protein uL14m XP_001395463.1 965747 D 5061 CDS An12g03900 4985738 complement(join(966548..966592,966655..966744,966944..967168)) III 1 NT_166527.1 Function: enzyme of S. cerevisiae is required for normal cell growth over a wide temperature range, but is not essential for synthesis of mRNA.; Title: strong similarity to 14.2 kD subunit of DNA-directed RNA polymerase II Rpb9 - Saccharomyces cerevisiae; nucleus; See PMID 1918023; uncharacterized protein 967168 4985738 An12g03900 Aspergillus niger uncharacterized protein XP_059604427.1 966548 R 5061 CDS An12g03910 4985739 join(967695..967697,967774..968177,968226..968342,968411..968420) III 1 NT_166527.1 Function: pin1 may modulate cell cycle control through interaction with Cdc25 and its activator, Plx1.; Function: the cis/trans peptidyl-prolyl isomerase,Pin1, is a regulator of mitosis that is well conserved from yeast to man.; Title: strong similarity to peptidyl-prolyl cis/trans isomerase pinA - Aspergillus nidulans; nucleus; uncharacterized protein 968420 4985739 An12g03910 Aspergillus niger uncharacterized protein XP_059604428.1 967695 D 5061 CDS An12g03920 4985740 complement(join(971750..971807,971867..972042,972094..974199,974260..974544)) III 1 NT_166527.1 Title: strong similarity to hypothetical protein EAA57929.1 - Aspergillus nidulans; uncharacterized protein 974544 4985740 An12g03920 Aspergillus niger uncharacterized protein XP_001395466.1 971750 R 5061 CDS An12g03930 4985741 join(974899..974964,975025..975119,975168..975212,975271..975462,975513..975645) III 1 NT_166527.1 Function: CBC mediates the effect of the cap structure in U snRNA export, and provide direct evidence for the involvement of a cellular RNA-binding factor in the transport of RNA to the cytoplasm.; Function: cap structures are added cotranscriptionally to all RNA polymerase II transcripts and affect several processes including RNA stability,pre-messenger RNA splicing, RNA export from the nucleus and translation initiation.; Localization: might be a nuclear protein.; Title: strong similarity to CAP binding protein CBP20-X - Xenopus laevis; See PMID 7651522; uncharacterized protein 975645 4985741 An12g03930 Aspergillus niger uncharacterized protein XP_001395467.1 974899 D 5061 CDS An12g03940 4985742 complement(join(975796..976369,976428..976681)) III 1 NT_166527.1 Remark: in Cercospora pyridoxine auxotrophy due to gene disruption.; Title: strong similarity to hypothetical pyridoxine synthesis protein PDX2 - Cercospora nicotianae; uncharacterized protein 976681 4985742 An12g03940 Aspergillus niger uncharacterized protein XP_001395468.1 975796 R 5061 CDS An12g03950 4985743 977120..978076 III 1 NT_166527.1 Remark: npgA of E. nidulans maps next to aatA and might also be involved in biosynthesis of penicillin or other antibiotics.; Title: strong similarity to hypothetical protein npgA - Aspergillus nidulans; uncharacterized protein 978076 4985743 An12g03950 Aspergillus niger uncharacterized protein XP_001395469.1 977120 D 5061 CDS An12g03960 4985744 complement(join(978445..978614,978673..979384)) III 1 NT_166527.1 Function: the penicillin biosynthesis is catalysed by three enzymes encoded by acvA (pcbAB), ipnA (pcbC) and ataA (penDE).; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to acyltransferase ataA -Aspergillus nidulans; See PMID 9729600; See PMID 10422583; uncharacterized protein 979384 4985744 An12g03960 Aspergillus niger uncharacterized protein XP_001395470.1 978445 R 5061 CDS An12g03970 4985745 complement(join(980245..980316,980381..982227,982277..982450,982556..982892)) III 1 NT_166527.1 Function: The recessive, temperature-sensitive bimA1 mutation of Aspergillus nidulans blocks nuclei in metaphase at restrictive temperature.; Function: the sequence of the bimA gene indicates that it is a member of a family of mostly nuclear proteins that contain a degenerate 34 amino acid repeat, the TPR (tetratricopeptide repeat) gene family. -; Title: strong similarity to nuclear protein bimA -Aspergillus nidulans; nucleus; uncharacterized protein 982892 4985745 An12g03970 Aspergillus niger uncharacterized protein XP_001395471.1 980245 R 5061 CDS An12g03980 4985746 join(983938..983946,984017..984538) III 1 NT_166527.1 Title: strong similarity to hypothetical protein AAN52526.1 - Pichia angusta; uncharacterized protein 984538 4985746 An12g03980 Aspergillus niger uncharacterized protein XP_001395472.1 983938 D 5061 CDS An12g03990 4985747 complement(join(985038..986760,986815..987401)) III 1 NT_166527.1 Title: strong similarity to hypothetical protein EAA57923.1 - Aspergillus nidulans; uncharacterized protein 987401 4985747 An12g03990 Aspergillus niger uncharacterized protein XP_001395473.3 985038 R 5061 CDS An12g04000 4985748 join(989071..992044,992097..993655) III 1 NT_166527.1 Function: it could also be an activator of 3'-5' ribonuclease or might be directly implicated in association with the RNA14 protein in the nuclear polyadenylation of the mRNAs.; Function: protein of S. cerevisiae may be a nuclease which would normally be inactive owing to inhibition by wild-type RNA14 protein and could be activated either as a normal component of mRNA decay or during some specific cellular stress.; Localization: integral membrane protein.; Similarity: shows similarity at carboxyterminus to several known and putative mrna stability proteins.; Title: similarity to mrna stability protein Ssm4 -Saccharomyces cerevisiae; uncharacterized protein 993655 4985748 An12g04000 Aspergillus niger uncharacterized protein XP_059604429.1 989071 D 5061 CDS An12g04010 4985749 join(994627..994663,994780..997995,998066..998499) III 1 NT_166527.1 Similarity: shows partial similarity mainly to Arabidopsis sequences.; Title: similarity to hypothetical protein encoded by An09g00360 - Aspergillus niger; uncharacterized protein 998499 4985749 An12g04010 Aspergillus niger uncharacterized protein XP_059604430.1 994627 D 5061 CDS An12g04020 4985750 complement(join(999579..1006109,1006180..1006350,1006427..1006576)) III 1 NT_166527.1 Catalytic activity: it converts ATP + Acetyl-CoA + HCO(3)(-) = ADP + + malonyl-CoA.; Catalytic activity: it converts ATP + biotin-carboxyl-carrier protein + CO(2) = ADP + Orthophosphate.; Cofactor: biotin.; Function: the S. pombe protein carries three functions i. e. biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.; Localization: cytoplasmic.; Pathway: first step in long-chain fatty acid synthesis.; Similarity: strong similarity to acetyl-CoA carboxylase accA A. nidulans.; Title: strong similarity to acetyl-CoA carboxylase SPAC56E4.04c - Schizosaccharomyces pombe; cytoplasm; See PMID 9871120; uncharacterized protein 1006576 4985750 An12g04020 Aspergillus niger uncharacterized protein XP_001395476.1 999579 R 5061 CDS An12g04030 4985751 complement(join(1011927..1013507,1013592..1013828)) III 1 NT_166527.1 Function: NUDE, is a homologue of the nuclear distribution protein RO11 of Neurospora crassa.; Function: movement and distribution of nuclei in fungi have been shown to be dependent on cytoplasmic microtubules and the microtubule-associated motor cytoplasmic dynein.; Similarity: similar to Neurospora crassa RO11.; Title: strong similarity to nuclear distribution protein nudE - Aspergillus nidulans; cytoplasm; See PMID 10931877; uncharacterized protein 1013828 4985751 An12g04030 Aspergillus niger uncharacterized protein XP_001395477.1 1011927 R 5061 CDS An12g04040 84592546 join(1017121..1017208,1017258..1017492,1017589..1017639,1017688..1018201) III 1 NT_166527.1 hypothetical protein 1018201 84592546 An12g04040 Aspergillus niger hypothetical protein XP_059604431.1 1017121 D 5061 CDS An12g04050 4985753 join(1019070..1019176,1019313..1019737,1019805..1019936,1019995..1020491,1020563..1020685) III 1 NT_166527.1 Remark: the ORF encoded protein also shows similarity to CSHase of Arthrobacter sp from patent R22271. .; Title: similarity to hypothetical protein b1011 -Escherichia coli; uncharacterized protein 1020685 4985753 An12g04050 Aspergillus niger uncharacterized protein XP_001395479.3 1019070 D 5061 CDS An12g04060 4985754 join(1021264..1021280,1021401..1021513,1021746..1023178) III 1 NT_166527.1 Remark: the ORF also shows similarity to the EST d1g09a1. r1 of Aspergillus nidulans.; Title: similarity to hypothetical protein SPAC29A4.06c - Schizosaccharomyces pombe; uncharacterized protein 1023178 4985754 An12g04060 Aspergillus niger uncharacterized protein XP_001395480.3 1021264 D 5061 CDS An12g04070 4985755 complement(join(1023472..1024698,1024753..1024883,1024935..1024989)) III 1 NT_166527.1 Phenotype: in S. cerevisiae zrt3 mutants inefficiently mobilize stored zinc to offset deficiency.; Remark: YKL175w is an alternative name for ZRT3.; Similarity: Zrt3p is a member of the ZIP family of metal transporters.; Title: similarity to zinc-transporter Zrt3 -Saccharomyces cerevisiae; vacuole; See PMID 10856230; uncharacterized protein 1024989 4985755 An12g04070 Aspergillus niger uncharacterized protein XP_001395481.1 1023472 R 5061 CDS An12g04080 84592547 complement(join(1025402..1025444,1025523..1025641)) III 1 NT_166527.1 hypothetical protein 1025641 84592547 An12g04080 Aspergillus niger hypothetical protein XP_059604432.1 1025402 R 5061 CDS An12g04090 4985757 join(1027187..1027649,1027756..1027787,1027947..1028060) III 1 NT_166527.1 Title: similarity to hypothetical protein encoded by An04g09490 - Aspergillus niger; uncharacterized protein 1028060 4985757 An12g04090 Aspergillus niger uncharacterized protein XP_001395483.3 1027187 D 5061 CDS An12g04100 4985758 complement(1028320..1029000) III 1 NT_166527.1 hypothetical protein 1029000 4985758 An12g04100 Aspergillus niger hypothetical protein XP_001395484.1 1028320 R 5061 CDS An12g04110 4985759 1029691..1030695 III 1 NT_166527.1 Phenotype: mitochondrial DNA recombination was reduced in an yeast mutant lacking the NUC1 endo/exonuclease.; Similarity: the ORF encoded protein shows strong similarity to several described mitochondrial nucleases.; Title: strong similarity to precursor of mitochondrial nuclease Nuc1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8087883; See PMID 2836791; uncharacterized protein 1030695 4985759 An12g04110 Aspergillus niger uncharacterized protein XP_001395485.1 1029691 D 5061 CDS An12g04120 4985760 complement(join(1031044..1031363,1031434..1031689,1031742..1032323)) III 1 NT_166527.1 Title: similarity to hypothetical protein T25B24.3 -Arabidopsis thaliana; uncharacterized protein 1032323 4985760 An12g04120 Aspergillus niger uncharacterized protein XP_001395486.1 1031044 R 5061 CDS An12g04130 84592548 complement(join(1032981..1034095,1034185..1034314)) III 1 NT_166527.1 Remark: blastp matches are unspecific.; hypothetical protein 1034314 84592548 An12g04130 Aspergillus niger hypothetical protein XP_059604433.1 1032981 R 5061 CDS An12g04140 4985762 complement(join(1036348..1038857,1038916..1040151,1040256..1040682)) III 1 NT_166527.1 Title: similarity to hypothetical Sec76 domain protein - Schizosaccharomyces pombe; uncharacterized protein 1040682 4985762 An12g04140 Aspergillus niger uncharacterized protein XP_001395488.1 1036348 R 5061 CDS An12g04150 84592549 join(1040832..1040962,1041081..1041203,1041443..1041563) III 1 NT_166527.1 Remark: blastp matches are due to repetitive amino acids.; hypothetical protein 1041563 84592549 An12g04150 Aspergillus niger hypothetical protein XP_059604434.1 1040832 D 5061 CDS An12g04160 84592550 join(1042514..1042628,1042961..1043053,1043136..1043235,1043564..1043657) III 1 NT_166527.1 hypothetical protein 1043657 84592550 An12g04160 Aspergillus niger hypothetical protein XP_059604435.1 1042514 D 5061 CDS An12g04170 4985765 join(1044540..1044950,1045023..1046477) III 1 NT_166527.1 Function: ECM14 of S. cerevisisae is involved in cell wall biogenesis and architecture.; Similarity: the ORF encoded protein shows similarity to different types of carboxypeptidases.; Title: similarity to Ecm14 - Saccharomyces cerevisiae; See PMID 9335584; uncharacterized protein 1046477 4985765 An12g04170 Aspergillus niger uncharacterized protein XP_001395491.1 1044540 D 5061 CDS An12g04180 4985766 complement(join(1047035..1048349,1048409..1048569,1048627..1048633,1048685..1048742,1048802..1048952)) III 1 NT_166527.1 Function: DIP5 of S. cerevisiae mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate.; Phenotype: the dip5 mutation caused a several hundred-fold reduction of uptake of L-glutamate and L-aspartate.; Remark: YPL265W is an alternative name for DIP5.; Similarity: DIP5 of S. cerevisiae belongs to the amino acid permease family.; Title: strong similarity to dicarboxylic amino acid permease Dip5 - Saccharomyces cerevisiae; plasma membrane; See PMID 9508791; uncharacterized protein 1048952 4985766 An12g04180 Aspergillus niger uncharacterized protein XP_001395492.1 1047035 R 5061 CDS An12g04190 4985767 complement(join(1050015..1051308,1051358..>1052874)) III 1 NT_166527.1 Remark: YBT1 and YLL048C are alternative names for BAT1.; Remark: the ORF encoded protein is N-terminally truncated due to the contig border.; Similarity: the ORF encoded protein shows similarity to various ABC transporters with different function.; Title: strong similarity to bile acid transporter Bat1 - Saccharomyces cerevisiae [truncated ORF]; vacuole; See PMID 9182565; uncharacterized protein 1052874 4985767 An12g04190 Aspergillus niger uncharacterized protein XP_001395493.3 1050015 R 5061 CDS An12g04200 84592551 join(1053229..1053344,1053433..1053451) III 1 NT_166527.1 hypothetical protein 1053451 84592551 An12g04200 Aspergillus niger hypothetical protein XP_059604436.1 1053229 D 5061 CDS An12g04210 4985769 join(1054623..1054712,1054768..1055920,1055973..1056349) III 1 NT_166527.1 Catalytic activity: PhacA catalyzes the ortho-hydroxylation of phenylacetate, the first step of A. nidulans phenylacetate catabolism.; Remark: Aspergillus nidulans utilizes phenylacetate as a carbon source via homogentisate, which is degraded to fumarate and acetoacetate.; Remark: PhacA is a novel cytochrome P450 monooxygenase.; Title: strong similarity to phenylacetate 2-hydroxylase phacA - Aspergillus nidulans; See PMID 10329644; uncharacterized protein 1056349 4985769 An12g04210 Aspergillus niger uncharacterized protein XP_001395495.1 1054623 D 5061 CDS An12g04220 4985770 join(1056583..1056678,1056737..1056852,1056923..1057401,1057483..1057619,1057670..1057738) III 1 NT_166527.1 Catalytic activity: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + NAD(+) = 3-alpha,12-alpha-dihydroxy-7-oxo-5-beta-cholanate + NADH.; Function: HdhA catalyses the oxidation of the 7-alpha-hydroxyl group of bile acids and alcohols both in their free and conjugated forms.; Title: similarity to 7-alpha-hydroxysteroid dehydrogenase hdhA - Escherichia coli; See PMID 2007545; uncharacterized protein 1057738 4985770 An12g04220 Aspergillus niger uncharacterized protein XP_001395496.1 1056583 D 5061 CDS An12g04230 84592552 complement(1058349..1059086) III 1 NT_166527.1 hypothetical protein 1059086 84592552 An12g04230 Aspergillus niger hypothetical protein XP_059604437.1 1058349 R 5061 CDS An12g04240 84592553 complement(join(1059463..1059499,1059631..1059926)) III 1 NT_166527.1 hypothetical protein 1059926 84592553 An12g04240 Aspergillus niger hypothetical protein XP_059604438.1 1059463 R 5061 CDS An12g04250 4985773 join(1061526..1061807,1061915..1062160,1062213..1062839,1062893..1063000,1063047..1063097,1063160..1063186,1063242..>1063306) III 1 NT_166527.1 Function: PDAT9 from the fungus Nectria haematococca encodes pisatin demethylase, an enzyme that detoxifies the phytoalexin pisatin, an antimicrobial compound produced by pea in response to infection by this plant pathogen.; Remark: a putative sequencing error results in an frameshift.; Similarity: PDAT9 is a cytochrome P450 whose deduced amino acid sequence is distinct from all other reported cytochrome P-450s, and therefore has been assigned to a new cytochrome P450 family, CYP57.; Title: strong similarity to cytochrome P450 pisatin demethylase PDAT9 - Nectria haematococca [putative frameshift]; putative frameshift; See PMID 2034215; See PMID 8208242; uncharacterized protein 1063306 4985773 An12g04250 Aspergillus niger uncharacterized protein XP_059604439.1 1061526 D 5061 CDS An12g04260 4985774 1063931..1064890 III 1 NT_166527.1 Catalytic activity: UDP-glucose = UDP-galactose.; Pathway: Galactose metabolism.; Title: similarity to UDP-glucose 4-epimerase GALE -Streptomyces lividans; See PMID 3335481; uncharacterized protein 1064890 4985774 An12g04260 Aspergillus niger uncharacterized protein XP_001395500.1 1063931 D 5061 CDS An12g04280 4985776 complement(join(1065772..1065804,1066064..1066802,1066856..1066976,1067039..1067087)) III 1 NT_166527.1 Function: The serine esterase est from Acinetobacter calcoaceticus confers the ability to grow on simple triglycerides such as triacetin (TAC).; Similarity: Belongs to the GDXG family of lipolytic enzymes.; Title: similarity to esterase est - Acinetobacter calcoaceticus; See PMID 2545531; uncharacterized protein 1067087 4985776 An12g04280 Aspergillus niger uncharacterized protein XP_059604440.1 1065772 R 5061 CDS An12g04310 4985779 <1069702..1070760 III 1 NT_166527.1 Catalytic activity: Cinnamyl alcohol+NADP(+)<=>cinnamaldehyde+NADPH.; Function: CAD1 from Eucalyptus gunnii catalyzes the reversible oxidation of cinnamyl alcohol to cinnamacetaldehyde with the concomitant reduction of NADP.; Pathway: lignin biosynthesis.; Remark: a putative sequencing error results in an frameshift.; Title: strong similarity to cinnamyl-alcohol dehydrogenase CAD1 - Eucalyptus gunnii [putative frameshift]; putative frameshift; See PMID 9526508; uncharacterized protein 1070760 4985779 An12g04310 Aspergillus niger uncharacterized protein XP_001395502.3 1069702 D 5061 CDS An12g04320 84592554 complement(join(1071255..1071308,1071420..1071590,1071636..1071719)) III 1 NT_166527.1 Title: weak similarity to hypothetical protein clone Bal50 - Unclassified organism; uncharacterized protein 1071719 84592554 An12g04320 Aspergillus niger uncharacterized protein XP_059604441.1 1071255 R 5061 CDS An12g04330 4985781 complement(join(1071898..1071939,1072008..1072361,1072442..1072678,1072742..1072761,1072834..1073244,1073298..1073403,1073457..1073535,1073634..1073695)) III 1 NT_166527.1 Catalytic activity: NADH + acceptor <=> NAD(+) + reduced acceptor.; Cofactor: FAD, FeS.; Title: strong similarity to thermostable NADH oxidase - Thermoanaerobium brockii; See PMID 1599437; See PMID 8357835; uncharacterized protein 1073695 4985781 An12g04330 Aspergillus niger uncharacterized protein XP_059604442.1 1071898 R 5061 CDS An12g04340 4985782 complement(join(1074256..1074734,1074795..1074926,1074984..1075270,1075322..1075587)) III 1 NT_166527.1 Function: the human zeta-crystallin/quinone reductase CRYZ is specific for NADPH. It catalyses the one electron reduction of certain quinones. Orthoquinones are the best substrates.; Similarity: the ORF encoded protein shows also strong similarities to many Arabidopsis thaliana patent oxidoreductases which are functionally not decribed.; Title: strong similarity to zeta-crystallin/quinone reductase CRYZ - Homo sapiens; See PMID 8466529; uncharacterized protein 1075587 4985782 An12g04340 Aspergillus niger uncharacterized protein XP_001395505.3 1074256 R 5061 CDS An12g04350 4985783 complement(join(1075989..1076115,1076275..1077308)) III 1 NT_166527.1 Catalytic activity: a carboxylic ester + H(2)O <=> an alcohol + a carboxylic anion.; Function: LipP from Pseudomonas sp. B11-1 is a lipase that showes a 1,3-positional specificity toward triolein. p-Nitrophenyl esters of fatty acids with short to medium chains (C4 and C6) served as good substrates.; Title: similarity to lipase LipP - Pseudomonas sp.; See PMID 9464382; uncharacterized protein 1077308 4985783 An12g04350 Aspergillus niger uncharacterized protein XP_001395506.3 1075989 R 5061 CDS An12g04360 4985784 join(1077568..1077624,1077654..1077822,1077853..1078146,1078224..1078858) III 1 NT_166527.1 Remark: the prostate specific androgen regulated protein ARSDR1 from patent WO200065067-A2 is identical to the androgen-regulated short-chain dehydrogenase/reductase 1 (TREMBL:AF167438_1).; Title: similarity to prostate specific androgen regulated protein ARSDR1 from patent WO200065067-A2 - Homo sapiens; See PMID 11245473; uncharacterized protein 1078858 4985784 An12g04360 Aspergillus niger uncharacterized protein XP_059604443.1 1077568 D 5061 CDS An12g04370 4985785 join(1079536..1079772,1079864..1080182,1080244..1080572,1080628..1080965,1081014..1081227) III 1 NT_166527.1 Remark: A. parasiticus moxY is part of the aflatoxin biosynthetic pathway gene cluster and is expressed concurrently with genes involved in aflatoxin biosynthesis.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Title: strong similarity to monooxygenase moxY -Aspergillus parasiticus; See PMID 10855719; uncharacterized protein 1081227 4985785 An12g04370 Aspergillus niger uncharacterized protein XP_059604444.1 1079536 D 5061 CDS An12g04380 4985786 complement(1081719..1082417) III 1 NT_166527.1 Title: strong similarity to immunogenic protein #19801 from patent WO200181581-A2 - Propionibacterium acnes; uncharacterized protein 1082417 4985786 An12g04380 Aspergillus niger uncharacterized protein XP_001395509.1 1081719 R 5061 CDS An12g04390 4985787 complement(1082889..1083926) III 1 NT_166527.1 Function: the 12-hydroxydehydrogenase LTB4DH from Sus scrofa catalyzes the conversion of leukotriene b4 into its biologically less active metabolite, 12-oxo-leukotriene b4. This is an initial and key step of metabolic inactivation of leukotriene b4 in various tissues other than leukocytes.; Similarity: the ORF encoded protein shows also strong similarities to many Arabidopsis thaliana patent oxidoreductases which are functionally not decribed.; Title: strong similarity to NADP dependent leukotriene b4 12-hydroxydehydrogenase LTB4DH - Sus scrofa; See PMID 8576264; uncharacterized protein 1083926 4985787 An12g04390 Aspergillus niger uncharacterized protein XP_001395510.1 1082889 R 5061 CDS An12g04410 84592555 complement(join(<1085954..1086029,1086262..1086359)) III 1 NT_166527.1 Remark: the ORF is short in length (58 amino acids) and has an unusual exon/intron structure for A. niger.; Title: questionable ORF; uncharacterized protein 1086359 84592555 An12g04410 Aspergillus niger uncharacterized protein XP_059606420.1 1085954 R 5061 CDS An12g04430 84592556 complement(1087115..1087687) III 1 NT_166527.1 hypothetical protein 1087687 84592556 An12g04430 Aspergillus niger hypothetical protein XP_059606421.1 1087115 R 5061 CDS An12g04440 84592557 join(1087717..1088038,1088431..1088672,1089059..1089418,1089514..1089655,1089796..1089884) III 1 NT_166527.1 hypothetical protein 1089884 84592557 An12g04440 Aspergillus niger hypothetical protein XP_059606422.1 1087717 D 5061 CDS An12g04450 4985793 1090166..1091167 III 1 NT_166527.1 Remark: the ORF contains many Prolins.; Title: similarity to EST SEQ ID NO:4177 from patent WO200056762-A2 - Aspergillus niger; uncharacterized protein 1091167 4985793 An12g04450 Aspergillus niger uncharacterized protein XP_001395514.1 1090166 D 5061 CDS An12g04460 84592558 join(1091473..1091633,1091974..1092013,1092088..1092169,1092234..1092415) III 1 NT_166527.1 Title: similarity to EST SEQ ID NO:4349 from patent WO200056762-A2 - Aspergillus niger; uncharacterized protein 1092415 84592558 An12g04460 Aspergillus niger uncharacterized protein XP_059606423.1 1091473 D 5061 CDS An12g04470 4985795 join(1092458..1092685,1092761..1092771,1092830..1092902,1092954..1093039,1093095..1093373,1093424..1093569,1093634..1093686,1093771..1094226) III 1 NT_166527.1 Remark: hoxN gene has several features typical of a hydrophobic integral membrane protein. Alkaline phosphatase fusion proteins produced by insertion of the transposon TnphoA into hoxN gave significant levels of alkaline phosphatase activity indicating that protein HoxN contains periplasmic domains. Taken together, our results suggest that gene hoxN encodes the high-affinity nickel transporter of A. eutrophus.; Title: strong similarity to high affinity nickel transporter - Ralstonia eutropha; See PMID 7896709; See PMID 7934894; See PMID 1847142; uncharacterized protein 1094226 4985795 An12g04470 Aspergillus niger uncharacterized protein XP_059606424.1 1092458 D 5061 CDS An12g04480 4985796 complement(join(1094849..1094910,1094972..1095336,1095397..1095689)) III 1 NT_166527.1 Catalytic activity: chitin + H2O = chitosan + acetate.; Pathway: aminosugars metabolism.; Remark: strong similarity to C. lindemuthianum chitin deacetylase patent DE19810349-A1.; Remark: the protein of the patent is also used to produce chitosan oligosaccharides from chitin oligosaccharides and for removing N-acetyl from other amino sugars, making it suitable for synthesis of new sugar chains.; Title: strong similarity to chitin deacetylase from patent DE19810349-A1 - Colletotrichum lindemuthianum; uncharacterized protein 1095689 4985796 An12g04480 Aspergillus niger uncharacterized protein XP_001395517.1 1094849 R 5061 CDS An12g04490 4985797 1097359..1099389 III 1 NT_166527.1 Remark: mRNA expression of pol lambda is highest in mouse testis and fetal liver. The biological function may differ from DNA translesion synthesis.; Title: strong similarity to DNA polymerase lambda POLL - Mus musculus; See PMID 10982892; uncharacterized protein 1099389 4985797 An12g04490 Aspergillus niger uncharacterized protein XP_001395518.1 1097359 D 5061 CDS An12g04500 4985798 complement(join(1099949..1100797,1100861..1101164,1101216..1104139)) III 1 NT_166527.1 Catalytic activity: ATP + H2O = ADP + orthophosphate.; Pathway: oxidative phosphorylation.; Remark: hydrolysis of ATP is coupled with the transport of Ca2+ ions. The enzyme from the plasma membrane of eucaryotes differs from that found in sarcoplasmic reticulum in that it is activated by calmodulin, is sensitive to low concentrations of vanadate, and is of higher molecular mass (150 kDa).; Similarity: belongs to the cation transport ATPases.; Title: strong similarity to transport ATPase Drs2 -Saccharomyces cerevisiae; See PMID 8247005; See PMID 9852106; See PMID 10601336; uncharacterized protein 1104139 4985798 An12g04500 Aspergillus niger uncharacterized protein XP_001395519.1 1099949 R 5061 CDS An12g04510 4985799 complement(join(1105743..1105927,1105977..1106514,1106586..1106920,1106993..1107184,1107249..1107727,1107793..1107830)) III 1 NT_166527.1 Catalytic activity: benzoate + NADPH + O2 = 4-hydroxybenzoate + NADP+ + H2O.; Induction: bphA of A. niger is inducible by benzoate.; Pathway: phenylalanine metabolism.; Remark: analysis revealed that CYP53 is a member of a P450 gene family designated P450LIII.; Similarity: belongs to the cytochrome P450 family.; Title: strong similarity to benzoate 4-monooxygenase cytochrome P450 53 bphA - Aspergillus niger; See PMID 2250647; uncharacterized protein 1107830 4985799 An12g04510 Aspergillus niger uncharacterized protein XP_001395520.1 1105743 R 5061 CDS An12g04520 4985800 complement(join(1109563..1109897,1109984..1110560,1110614..1111306)) III 1 NT_166527.1 Function: probable transporter. confers resistance to cycloheximide.; Remark: the CYHR gene from Candida maltosa confers resistance to cycloheximide.; Similarity: belongs to the major facilitator family (also known as the drug resistance translocase family). belongs to the car1/cyhr subfamily.; Title: strong similarity to cycloheximide resistance protein CYHR - Candida maltosa; plasma membrane; See PMID 1628836; uncharacterized protein 1111306 4985800 An12g04520 Aspergillus niger uncharacterized protein XP_001395521.1 1109563 R 5061 CDS An12g04530 84592559 join(1111856..1112135,1112190..1113027,1113143..>1113774) III 1 NT_166527.1 Catalytic activity: versicolorin B synthase of A. parasiticus catalyzes the side chain cyclization of racemic versiconal hemiacetal to the bisfuran ring system of versicolorin B.; Pathway: versicolorin B synthase catalyzes an essential transformation in the aflatoxin biosynthetic pathway of A. parasiticus.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Remark: putative sequencing error at position 27713,1 base too much and at position 26638; putative sequencing error leads to a STOP Codon.; Remark: the biosynthesis of aflatoxin B1 proceeds through three configurationally labile intermediates to racemic versiconal hemiacetal. Subsequent enzymatic cyclization establishes the stereochemistry of this,critical ring fusion in (-)-versicolorin B and is catalyzed by versicolorin B synthase (VBS).; Remark: vbs of A. parasiticus possesses an amino-terminal sequence homologous to the ADP-binding region of other flavoenzymes; however, this enzyme does not require flavin or nicotinamide cofactors for its cyclase activity.; Similarity: belongs to the choline dehydrogenase and related flavoproteins.; Title: strong similarity to versicolorin B synthase vbs - Aspergillus parasiticus [putative frameshift]; putative frameshift; See PMID 8662689; See PMID 8784203; uncharacterized protein 1113774 84592559 An12g04530 Aspergillus niger uncharacterized protein XP_059606425.1 1111856 D 5061 CDS An12g04540 4985802 complement(join(1113948..1114046,1114098..1114682,1114850..1115382,1115424..1115542,1116001..1116058,1116134..1116229,1116536..1116615,1116738..1116950,1117024..1117113,1117192..1117290,1117382..1117965,1118025..1118264)) III 1 NT_166527.1 Title: weak similarity to hypothetical protein CAD60719.1 - Podospora anserina; uncharacterized protein 1118264 4985802 An12g04540 Aspergillus niger uncharacterized protein XP_059606426.1 1113948 R 5061 CDS An12g04550 84592560 join(1120095..1120125,1120214..1120315,1120412..1120501,1120630..1120706,1120761..1120800,1120830..1120879) III 1 NT_166527.1 hypothetical protein 1120879 84592560 An12g04550 Aspergillus niger hypothetical protein XP_059606427.1 1120095 D 5061 CDS An12g04560 4985804 complement(join(1121029..1121623,1121685..1121804,1121865..1122028)) III 1 NT_166527.1 Complex: the human 75-kD autoantigen (PM-Sc1) is part of the nuclear/nucleolar particle termed PM-Scl (polymyositis/scleroderma). the PM-Scl complex consists of 11 to 16 proteins.; Remark: the PM/Scl complex is the human counterpart of the yeast (S. cerevisiae) exosome, which is an RNA-processing complex consisting of 11 3' --> 5' exoribonucleases.; Remark: the exosome plays a major role in diverse RNA processing and degradation pathways.; Remark: yeast Rrp45p is homologous to PM-Scl75.; Similarity: the predicted A. niger protein shows strong similarity to the human 75-kD autoantigen (PM-Sc1) and related conserved hypothetical proteins from procaryotic and eucaryotic species, which belong to the RNase PH family.; Title: strong similarity to 75-kD autoantigen PM-Sc1 - Homo sapiens; See PMID 10465791; See PMID 11178117; See PMID 2007859; uncharacterized protein 1122028 4985804 An12g04560 Aspergillus niger uncharacterized protein XP_001395525.1 1121029 R 5061 CDS An12g04570 4985805 join(1122278..1122287,1122341..1122363,1122412..1122488,1122536..1122820,1122872..1122956,1123006..1123176,1123232..1123297) III 1 NT_166527.1 Title: strong similarity to hypothetical protein BAA90629.1 - Oryza sativa; uncharacterized protein 1123297 4985805 An12g04570 Aspergillus niger uncharacterized protein XP_001395526.3 1122278 D 5061 CDS An12g04580 4985806 join(1123467..1123546,1123593..1123845,1124050..1124118,1124204..1124382,1124556..1124601) III 1 NT_166527.1 hypothetical protein 1124601 4985806 An12g04580 Aspergillus niger hypothetical protein XP_059606428.1 1123467 D 5061 CDS An12g04590 4985807 join(1124847..1125602,1125659..1125724) III 1 NT_166527.1 Catalytic activity: 5,6,7,8-tetrahydrofolate + NADP(+) <=> 7,8-dihydrofolate + NADPH; Function: dihydrofolate reductase catalyzes the reduction of dihydrofolic acid to tetrahydrofolic acid with NADPH an essential step in de novo synthesis both of glycine and of purines and deoxythymidine phosphate (the precursors of DNA synthesis), and important also in the conversion of deoxyuridine monophosphate to deoxythymidine monophosphate.; Similarity: similarity to dihydrofolate reductase of several species is restricted to aminoterminus.; Title: similarity to dihydrofolate reductase DHFR -Pneumocystis carinii; See PMID 2682653; uncharacterized protein 1125724 4985807 An12g04590 Aspergillus niger uncharacterized protein XP_001395528.3 1124847 D 5061 CDS An12g04600 4985808 complement(join(1126026..1126151,1126183..1126569,1126625..1127813,1127970..1128643)) III 1 NT_166527.1 Function: CIC-3 in rat may play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C.; Remark: a splice site was detected upstream of the START codon.; Remark: alternative splicing at the aminoterminus possible because of long and short forms of chloride channels.; Similarity: strong similarity to chloride channels at the aminoterminus but no similarity at the carboxyterminus.; Title: similarity to protein kinase C-regulated chloride channel ClC3 - Rattus rattus; See PMID 8155321; uncharacterized protein 1128643 4985808 An12g04600 Aspergillus niger uncharacterized protein XP_059606429.1 1126026 R 5061 CDS An12g04610 4985809 1133802..1134638 III 1 NT_166527.1 Function: might be involved in degradation of cellulose or similiar substances.; Similarity: restricted to aminoterminus, partial similarity might point to a pseudogene.; Title: similarity to endoglucanase IV egl4 -Trichoderma reesei; See PMID 9370370; uncharacterized protein 1134638 4985809 An12g04610 Aspergillus niger uncharacterized protein XP_001395530.1 1133802 D 5061 CDS An12g04620 4985810 join(1136198..1136452,1136511..1136934,1136985..1137726,1137787..1137919) III 1 NT_166527.1 Function: might be a membrane transporter used in A. chrysogenum to improve the fermentation ability.; Remark: patent W14439 against protein.; Title: similarity to protein involved in cephalosporin C biosynthesis from patent JP09009966-A -Acremonium chrysogenum; uncharacterized protein 1137919 4985810 An12g04620 Aspergillus niger uncharacterized protein XP_059606430.1 1136198 D 5061 CDS An12g04630 4985811 join(1139935..1140275,1140330..1140378,1140447..1141403) III 1 NT_166527.1 Function: PVA is used for the enzymatic hydrolysis of penicillin V (phenoxy-methylpenicillin) to 6-aminopenicillanic acid (6-APA).; Remark: alternative splicing possible.; Similarity: shows strong similarity to proteins of patents W00291 (full length) and W00290 (mature).; Title: strong similarity to full length Penicillin V amidohydrolase from patent US5516679-A - Fusarium oxysporum; uncharacterized protein 1141403 4985811 An12g04630 Aspergillus niger uncharacterized protein XP_001395532.3 1139935 D 5061 CDS An12g04640 4985812 join(1142083..1142221,1142278..1142317,1142384..1142462,1142521..1143045) III 1 NT_166527.1 Function: isoamyl acetate hydrolytic enzyme of S. cerevisiae is involved in C-compound and carbohydrate utilization and fermentation.; Function: might be a lipase/acylhydrolase with GDSL-like motif according to pfam-domain.; Remark: patent not found in DSM-patentdatabase.; Similarity: shows also similarity to isoamyl acetate hydrolytic enzyme of S. cerevisiae.; Title: similarity to sequence 28 from patent WO0032789 - Mangifera indica; uncharacterized protein 1143045 4985812 An12g04640 Aspergillus niger uncharacterized protein XP_001395533.1 1142083 D 5061 CDS An12g04650 4985813 join(1144220..1144421,1144498..1145963) III 1 NT_166527.1 Title: weak similarity to hypothetical secreted antigen SagA - Enterococcus faecium; uncharacterized protein 1145963 4985813 An12g04650 Aspergillus niger uncharacterized protein XP_001395534.1 1144220 D 5061 CDS An12g04655 4985814 complement(join(1146099..1146624,1146687..1146738,1146905..1146935)) III 1 NT_166527.1 Title: strong similarity to hypothetical protein AAF47250.1 - Drosophila melanogaster; uncharacterized protein 1146935 4985814 An12g04655 Aspergillus niger uncharacterized protein XP_059606431.1 1146099 R 5061 CDS An12g04660 4985815 complement(join(1147200..1147454,1147506..1147606,1147652..1148028,1148084..1148497,1148547..1148682,1148732..1148908,1148959..1149058)) III 1 NT_166527.1 Function: gene disruption demonstrated that the thi6 null strain is auxotrophic for thiamin, indicating that the THI6 protein is essential for thiamin synthesis in yeast.; Function: thiamin-phosphate pyrophosphorylase (TMP-PPase; EC 2. 5. 1. 3) involved in de novo synthesis of thiamin in S. cerevisiae is a bifunctional enzyme with 4-methyl-5-beta-hydroxyethylthiazole kinase (Th-kinase; EC 2. 7. 1. 50) activity.; Title: strong similarity to thiamin-phosphate pyrophosphorylase/hydroxyethylthiazole kinase Thi6 -Saccharomyces cerevisiae; See PMID 7982968; uncharacterized protein 1149058 4985815 An12g04660 Aspergillus niger uncharacterized protein XP_001395536.1 1147200 R 5061 CDS An12g04670 4985816 1151209..1152486 III 1 NT_166527.1 Function: eukaryotic translation initiation factor 5 (eIF-5) catalyzes hydrolysis of GTP bound to a 40 S ribosomal initiation complex with the subsequent joining of a 60 S ribosomal subunit to form an 80 S initiation complex.; Remark: a splice site was detected upstream of the START codon.; Remark: translation initiation factor eIF-5 exists as long and short form (alternative splicing).; Title: strong similarity to translation initiation factor Eif-5 - Saccharomyces cerevisiae; cytoplasm; uncharacterized protein 1152486 4985816 An12g04670 Aspergillus niger uncharacterized protein XP_001395537.1 1151209 D 5061 CDS An12g04680 4985817 complement(join(1152965..1156480,1156526..1156558)) III 1 NT_166527.1 Title: similarity to hypothetical protein SPCC622.13c - Schizosaccharomyces pombe; uncharacterized protein 1156558 4985817 An12g04680 Aspergillus niger uncharacterized protein XP_059606432.1 1152965 R 5061 CDS An12g04690 4985818 join(1157351..1158569,1158624..1159009,1159061..1159333,1159384..1159614,1159665..1160210) III 1 NT_166527.1 Function: DNA ligases catalyze the formation of phosphodiester bonds at single-strand breaks in double-strand DNA.; Similarity: DNA ligases of several species seem to be highly variable at the aminoterminus.; Title: strong similarity to ATP-dependent DNA ligase LigI - Xenopus laevis; nucleus; See PMID 8682316; uncharacterized protein 1160210 4985818 An12g04690 Aspergillus niger uncharacterized protein XP_059606433.1 1157351 D 5061 CDS An12g04700 4985819 join(1160899..1160966,1161032..1161083,1161141..1161379,1161438..1162449,1162509..1162731,1162794..1163026,1163109..1163320,1163405..1163546) III 1 NT_166527.1 Function: Tri r 4 is associated with IgE antibody binding and delayed type hypersensitivity in Homo sapiens.; Function: dipeptidyl peptidase IV (DPP IV) is responsible for the removal of N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini, provided that the penultimate residue is proline.; Similarity: similarity to several peptidase families.; Title: strong similarity to allergen Tri r 4 -Trichophyton rubrum; uncharacterized protein 1163546 4985819 An12g04700 Aspergillus niger uncharacterized protein XP_001395540.1 1160899 D 5061 CDS An12g04710 4985820 complement(join(1164126..1164520,1164576..1165884,1165938..1166183,1166247..1166718,1166788..1166792)) III 1 NT_166527.1 Function: a novel gene family in which null mutations cause pleiotropic effects on metal-ion resistance or sensitivity and distribution of membrane proteins in different targets was discovered.; Function: deletion of the VTC1 gene (DeltaVTC1) results in a reduced amount of V-ATPase in the vacuolar membrane.; Function: the family was defined as VTC (Vacuolar Transporter Chaperon) and it contains four genes in the S. cerevisiae genome.; Function: these mutant cells fail to accumulate quinacrine into their vacuoles, but they are able to grow at pH 7. 5. The VTC1 null mutant also results in a reduced amount of the plasma membrane H(+)-ATPase (Pma1p) in membrane preparations and possibly mis-targeting.; Similarity: similarity to VTC1 is only partial because VTC1 is much smaller but the predicted protein might be a member of the same family.; Similarity: strong similarity to several fungal hypothetical proteins.; Title: similarity to negative regulator of Cdc Fourty two Vtc1 - Saccharomyces cerevisiae; See PMID 10480897; uncharacterized protein 1166792 4985820 An12g04710 Aspergillus niger uncharacterized protein XP_001395541.1 1164126 R 5061 CDS An12g04720 4985821 complement(join(1169612..1170199,1170257..1171449,1171500..1171571,1171622..1171720,1171811..1172491,1172548..1172911)) III 1 NT_166527.1 Complex: the predominant form is a heterohexamer of MCM2, MCM3, MCM4, MCM5, MCM6, and MCM7, sometimes called the RLF-M component of replication licensing factor.; Function: as replication proceeds, MCM proteins are phosphorylated and dissociate from the chromatin.; Function: part of the replication licensing system that permits DNA replication to occur once and only once within a single cell division cycle.; Function: the complex of six MCM proteins is one of several proteins that must be bound at the origins of replication for the initiation of DNA replication.; Title: strong similarity to replication licensing factor mcm4p - Schizosaccharomyces pombe; nucleus; uncharacterized protein 1172911 4985821 An12g04720 Aspergillus niger uncharacterized protein XP_059606434.1 1169612 R 5061 CDS An12g04730 4985822 join(1173443..1173466,1173496..1173566,1173887..1174040,1174221..1174414,1174477..1176905,1176961..1177979) III 1 NT_166527.1 Similarity: shows only wear similarity at the aminoterminus.; Title: similarity to hypothetical membrane protein YMR266w - Saccharomyces cerevisiae; uncharacterized protein 1177979 4985822 An12g04730 Aspergillus niger uncharacterized protein XP_059606435.1 1173443 D 5061 CDS An12g04740 4985823 complement(1178219..1179529) III 1 NT_166527.1 Function: N-delta-arginine methylation may be important during logarithmic growth and may be dispensable or even deleterious during post-exponential growth.; Title: similarity to N-delta-arginine methyltransferase Rmt2 - Saccharomyces cerevisiae; See PMID 9873020; uncharacterized protein 1179529 4985823 An12g04740 Aspergillus niger uncharacterized protein XP_001395544.1 1178219 R 5061 CDS An12g04750 4985824 complement(join(1180109..1180432,1180487..1180842,1180896..1180964,1181024..1181195)) III 1 NT_166527.1 Complex: Phb2p of S. cerevisiae forms a large multimeric complex with Phb1p.; Function: Phb1/Phb2 complex of S. cerevisiae is involved in stabilization of mitochondrial proteins.; Function: prohibitins are ubiquitous, abundant and evolutionarily strongly conserved proteins that play a role in important cellular processes.; Function: prohibitins in S. cerevisiae regulate membrane protein degradation and replicative lifespan.; Remark: the systematic genenmae of PHB2 of S. cerevisiae is YGR231C.; Title: strong similarity to prohibitin Phb2 -Saccharomyces cerevisiae; See PMID 9259555; See PMID 9632789; See PMID 10207067; See PMID 10835343; uncharacterized protein 1181195 4985824 An12g04750 Aspergillus niger uncharacterized protein XP_001395545.1 1180109 R 5061 CDS An12g04760 4985825 join(1181590..1181638,1181712..1182550) III 1 NT_166527.1 Complex: CF I in S. cerevisiae contains five subunits, Rna14, Rna15, Pcf11, Clp1 and Hrp1.; Complex: subunit of cleavage factor I (CF I).; Function: CF I is involved in pre-mRNA 3'-end processing.; Remark: the systematic genename of RNA15 of S. cerevisiae is YGL044C.; Title: strong similarity to cleavage and polyadenylation factor CF I component Rna15 - Saccharomyces cerevisiae; See PMID 11344258; uncharacterized protein 1182550 4985825 An12g04760 Aspergillus niger uncharacterized protein XP_001395546.1 1181590 D 5061 CDS An12g04770 4985826 join(1184090..1184474,1184526..1184670,1184718..1185449,1185501..1190360,1190438..1190688,1190893..1190936) III 1 NT_166527.1 Remark: might be a transcription factor, despite the only weak similarity to other proteins, but some motifs are present.; Title: weak similarity to helicase-like transcription factor HLTF-1 - Homo sapiens; uncharacterized protein 1190936 4985826 An12g04770 Aspergillus niger uncharacterized protein XP_059606436.1 1184090 D 5061 CDS An12g04780 4985827 complement(join(1191397..1191792,1191868..1192158,1192289..1192411)) III 1 NT_166527.1 Catalytic activity: NADH:ubiquinone reductase catalyzes the conversion of NADH + ubiquinone = NAD+ + ubiquinol.; Function: the 24 kD subunit of respiratory chain complex I is believed to be a component of the flavoprotein-sulfur fragment.; Title: strong similarity to 24 kD subunit of NADH:ubiquinone reductase Nuo24 - Neurospora crassa; localisation:mitochondrion; uncharacterized protein 1192411 4985827 An12g04780 Aspergillus niger uncharacterized protein XP_001395548.1 1191397 R 5061 CDS An12g04790 4985828 complement(1192786..1193382) III 1 NT_166527.1 Title: similarity to hypothetical protein PA3762 -Pseudomonas aeruginosa; uncharacterized protein 1193382 4985828 An12g04790 Aspergillus niger uncharacterized protein XP_001395549.1 1192786 R 5061 CDS An12g04800 4985829 complement(1193670..1194743) III 1 NT_166527.1 Catalytic activity: adenosine deaminase catalyzes the conversion of adenosine + H2O = inosine + NH3.; Pathway: adenosine deaminase is an enzyme of the purine salvage pathway.; Remark: the systenatic name of AAH1 of S. cerevisiae is YNL141W.; Title: strong similarity to adenosine deaminase Aah1 - Saccharomyces cerevisiae; See PMID 3072477; See PMID 6392474; See PMID 9335580; uncharacterized protein 1194743 4985829 An12g04800 Aspergillus niger uncharacterized protein XP_001395550.1 1193670 R 5061 CDS An12g04810 4985830 complement(join(1195632..1195836,1195948..1196936)) III 1 NT_166527.1 Function: SUA5 is a gene required for normal growth in S. cerevisiae.; Function: SUA5 is annotatied at the yeast databases SGD, YPD, and MIPS as being involved in translation initation.; Title: strong similarity to protein involved in translation initiation Sua5 - Saccharomyces cerevisiae; See PMID 1325384; See PMID 1666843; uncharacterized protein 1196936 4985830 An12g04810 Aspergillus niger uncharacterized protein XP_059606437.1 1195632 R 5061 CDS An12g04820 4985831 complement(join(1197616..1199251,1199305..1200893,1200959..1201276)) III 1 NT_166527.1 Title: strong similarity to hypothetical conserved protein SPCC132.01c - Schizosaccharomyces pombe; uncharacterized protein 1201276 4985831 An12g04820 Aspergillus niger uncharacterized protein XP_059606438.1 1197616 R 5061 CDS An12g04830 4985832 complement(join(1201748..1201988,1202062..1202284,1202318..1202426)) III 1 NT_166527.1 Complex: the coatomer is an oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta,epsilon and zeta subunits.; Function: the coatomer complex is required for budding from golgi membranes, and is essential for the retrograde golgi-to-ER transport of dilysine-tagged proteins.; Function: the coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER,via the golgi up to the trans golgi network.; Function: the coatomer zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.; Remark: the systematic name of RET3 is YPL010W.; Title: strong similarity to coatomer protein zeta chain Ret3 - Saccharomyces cerevisiae; See PMID 8617224; uncharacterized protein 1202426 4985832 An12g04830 Aspergillus niger uncharacterized protein XP_059606439.1 1201748 R 5061 CDS An12g04840 4985833 complement(1203209..1205224) III 1 NT_166527.1 Title: similarity to hypothetical nuclear protein -Xenopus laevis; uncharacterized protein 1205224 4985833 An12g04840 Aspergillus niger uncharacterized protein XP_059606440.1 1203209 R 5061 CDS An12g04850 84592561 join(1206957..1206959,1207126..1207267,1207364..1207386) III 1 NT_166527.1 Title: questionable ORF; uncharacterized protein 1207386 84592561 An12g04850 Aspergillus niger uncharacterized protein XP_059606441.1 1206957 D 5061 CDS An12g04860 4985835 join(1208345..1208417,1208481..1208518,1208591..1208707,1208833..1208925) III 1 NT_166527.1 Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L30 - Saccharomyces cerevisiae; cytoplasm; 60S ribosomal protein eL30 1208925 4985835 An12g04860 Aspergillus niger 60S ribosomal protein eL30 XP_001395556.1 1208345 D 5061 CDS An12g04870 4985836 join(1209506..1209550,1209767..1209942,1210002..1210452) III 1 NT_166527.1 Function: L10 of S. cerevisiae is involved in control of cell growth and proliferation.; Remark: L10 of S. cerevisiae is also called L9, GRC5, L2341, YLR075w, or QSR1.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L10 - Saccharomyces cerevisiae; cytoplasm; See PMID 9301022; 60S ribosomal protein uL16 1210452 4985836 An12g04870 Aspergillus niger 60S ribosomal protein uL16 XP_001395557.1 1209506 D 5061 CDS An12g04880 4985837 join(1212449..1214257,1214375..1214398) III 1 NT_166527.1 hypothetical protein 1214398 4985837 An12g04880 Aspergillus niger hypothetical protein XP_001395558.3 1212449 D 5061 CDS An12g04890 4985838 join(1214883..1215136,1215240..1215278,1215394..1216258) III 1 NT_166527.1 Title: weak similarity to proline iminopeptidase homolog MG310 - Mycoplasma genitalium; uncharacterized protein 1216258 4985838 An12g04890 Aspergillus niger uncharacterized protein XP_001395559.3 1214883 D 5061 CDS An12g04900 4985839 join(<1218813..1219096,1219160..1219370,1219431..1220521,1220777..1220805,1220871..1220949,1220980..1221103,1221163..1221783,1221831..1222199,1222257..>1222384) III 1 NT_166527.1 Remark: truncated due to end of contig.; Title: strong similarity to hypothetical protein CAE85584.1 - Neurospora crassa [truncated ORF]; uncharacterized protein 1222384 4985839 An12g04900 Aspergillus niger uncharacterized protein XP_059599543.1 1218813 D 5061 CDS An12g04910 4985840 complement(join(<1222533..1222591,1222652..1224793)) III 1 NT_166527.1 Remark: Prp16 is an essential yeast splicing factor that catalyzes RNA-dependent hydrolysis of nucleoside triphosphates. Prp16 is a member of the DEAH-box protein family, which is defined by six co-linear sequence motifs.; Remark: might be C-terminally truncated due to contig end.; Title: strong similarity to mRNA splicing factor Prp16 - Saccharomyces cerevisiae [truncated ORF]; See PMID 9550699; See PMID 9611193; uncharacterized protein 1224793 4985840 An12g04910 Aspergillus niger uncharacterized protein XP_001395561.3 1222533 R 5061 CDS An12g04920 4985841 complement(join(1225145..1226407,1226464..1226847)) III 1 NT_166527.1 Title: similarity to hypothetical protein SPCC70.11c - Schizosaccharomyces pombe; uncharacterized protein 1226847 4985841 An12g04920 Aspergillus niger uncharacterized protein XP_001395562.1 1225145 R 5061 CDS An12g04930 4985842 join(1227473..1227596,1227653..1228776) III 1 NT_166527.1 Similarity: shows similarity to several putative mitochondrial carrier proteins.; Title: strong similarity to hypothetical mitochondrial carrier protein SPBP23A10.06 -Schizosaccharomyces pombe; See PMID 2158156; See PMID 8206158; uncharacterized protein 1228776 4985842 An12g04930 Aspergillus niger uncharacterized protein XP_001395563.3 1227473 D 5061 CDS An12g04940 4985843 complement(join(1229904..1231417,1231485..1231626,1231709..1231816)) III 1 NT_166527.1 Function: in S. cerevisiae lack of functional Hsp60 did not result in increased folding, but in the aggregation of protein, suggesting that Hsp60 and Hsp70 act in an ordered pathway with substrate transfer predominantly in the direction from Hsp70 to Hsp60.; Function: protein folding in mitochondria depends on the functional cooperation of the Hsp70 and Hsp60 chaperone systems, at least for a subset of mitochondrial polypeptides.; Title: strong similarity to mitochondrial heat shock protein Hsp60 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9476895; See PMID 9563826; uncharacterized protein 1231816 4985843 An12g04940 Aspergillus niger uncharacterized protein XP_001395564.1 1229904 R 5061 CDS An12g04950 4985844 join(1233382..1233413,1233488..1233602,1233699..1233764) III 1 NT_166527.1 Function: F-type ATPases have 2 components, cf(1) -the catalytic core and cf(0) the membrane proton channel. cf(1) has five subunits: alpha(3), beta(3), gamma(1),delta(1), epsilon(1). cf(0) has three main subunits: a, b and c.; Function: the epsilon subunit is the smallest of the 5 chains of the enzymatic component (coupling factor cf(1)) of the mitochondrial ATPase complex.; Title: strong similarity to epsilon chain of mitochondrial ATP-Synthase - Ipomoea batatas; localisation:mitochondrion; See PMID 8349605; uncharacterized protein 1233764 4985844 An12g04950 Aspergillus niger uncharacterized protein XP_059604445.1 1233382 D 5061 CDS An12g04960 4985845 join(1234226..1234450,1234533..1234673,1234745..1234981,1235042..1235500,1235554..1235811,1235886..1235984,1236034..1236978) III 1 NT_166527.1 Function: S. cererevisiae MAK10 is necessary for the propagation of the L-A dsRNA virus.; Function: in S. cerevisiae loss of L-A by mak10-1 mutants is partially suppressed by loss of the mitochondrial genome, suggesting that the mitochondrial genome and L-A dsRNA compete for the MAK10 protein.; Repression: S. cererevisiae MAK10 is glucose repressible.; Title: strong similarity to Mak10 - Saccharomyces cerevisiae; See PMID 1398065; uncharacterized protein 1236978 4985845 An12g04960 Aspergillus niger uncharacterized protein XP_059604446.1 1234226 D 5061 CDS An12g04970 84592562 join(1239492..1240512,1240684..1240774,1240924..1241860) III 1 NT_166527.1 Similarity: similarity is confined to N-terminal 50 aa containing the Zn-finger DNA-binding motif.; Title: weak similarity to zinc-finger transcription factor CAA19035.1 - Schizosaccharomyces pombe; uncharacterized protein 1241860 84592562 An12g04970 Aspergillus niger uncharacterized protein XP_059604447.1 1239492 D 5061 CDS An12g04975 84592563 complement(join(1242180..1242650,1242868..1243080,1243211..1243489)) III 1 NT_166527.1 hypothetical protein 1243489 84592563 An12g04975 Aspergillus niger hypothetical protein XP_059604448.1 1242180 R 5061 CDS An12g04980 84592564 complement(join(1245022..1245051,1245137..1245202)) III 1 NT_166527.1 Remark: ORF questionable due to short length.; Title: questionable ORF; uncharacterized protein 1245202 84592564 An12g04980 Aspergillus niger uncharacterized protein XP_059604449.1 1245022 R 5061 CDS An12g04990 4985849 1246449..1247246 III 1 NT_166527.1 Catalytic activity: D-sorbitol 6-phosphate + NAD(+) <=> D-fructose 6-phosphate + NADH.; Remark: glucitol is synonymous to sorbitol.; Title: strong similarity to glucitol 6-phosphate dehydrogenase gutD - Clostridium beijerinckii; See PMID 9572925; uncharacterized protein 1247246 4985849 An12g04990 Aspergillus niger uncharacterized protein XP_001395570.1 1246449 D 5061 CDS An12g05000 4985850 1249008..1250654 III 1 NT_166527.1 Catalytic activity: Cyclohexanone + NADPH + O(2) <=> 6-hexanolide + NADP(+) + H(2)O.; Function: chnB from Acinetobacter is a FAD monooxygenase and catalyzes the conversion of cyclohexanone to caprolactone in the cyclohexanol oxidation.; Title: strong similarity to cyclohexanone monooxygenase chnB - Acinetobacter sp.; See PMID 10940013; uncharacterized protein 1250654 4985850 An12g05000 Aspergillus niger uncharacterized protein XP_001395571.1 1249008 D 5061 CDS An12g05010 4985851 join(1252363..1252564,1252636..1252892,1252973..1253425) III 1 NT_166527.1 Catalytic activity: a carboxylic ester + H(2)O <=> an alcohol + a carboxylic anion.; Function: aceA from A. awamori liberates acetic acid from wheat bran, and hydrolysed alpha-naphthyl acetate and propionate only when aromatic esters were used for the substrate.; Gene-ID: aceA;axeA; Remark: aceA from A. niger is described in Patent number EP0507369-A/7, 07-OCT-1992, GIST-BROCADES.; See PMID 9291122; acetyl xylan esterase axeA-Aspergillus niger 1253425 aceA 4985851 aceA Aspergillus niger acetyl xylan esterase axeA-Aspergillus niger XP_001395572.1 1252363 D 5061 CDS An12g05020 84592565 complement(join(1254612..1254638,1254909..1254992,1255050..1255145)) III 1 NT_166527.1 Function: hydrophobins lower the water surface tension, coat aerial hyphae with a hydrophobic layer and mediate attachment of hyphae to hydrophobic surfaces.; Localization: HFBI from T. reesei is secreted.; Title: similarity to hydrophobin HFBI - Trichoderma reesei; See PMID 8631337; See PMID 10998570; uncharacterized protein 1255145 84592565 An12g05020 Aspergillus niger uncharacterized protein XP_059604450.1 1254612 R 5061 CDS An12g05030 4985853 join(1259683..1261522,1261576..1261800,1261849..1261880) III 1 NT_166527.1 Function: SKT5 from S. cerevisiae is a posttranlational activator of chitin synthase 3 activity by combining with Chs3p to interact synergistically in chitin biosynthesis.; Remark: CAL2, CHS4 and CSD4 are synonymous for SKT5.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to enzyme activator protein Skt5 - Saccharomyces cerevisiae; See PMID 9234668; uncharacterized protein 1261880 4985853 An12g05030 Aspergillus niger uncharacterized protein XP_001395574.1 1259683 D 5061 CDS An12g05040 84592566 complement(join(1262028..1262161,1262278..1262342,1262830..1262930)) III 1 NT_166527.1 Title: similarity to hypothetical protein lin-10 -Caenorhabditis elegans; uncharacterized protein 1262930 84592566 An12g05040 Aspergillus niger uncharacterized protein XP_059604451.1 1262028 R 5061 CDS An12g05050 4985855 1263927..1265978 III 1 NT_166527.1 Function: semi-dominant mutations in the amdA gene of E. nidulans lead to elevated expression of the gene encoding acetamidase, amdS.; Function: the C2H2 zinc-finger motifs identified in the protein of E. nidulans are similar to those found in the carbon catabolite repressor protein, CreA, which also regulates amdS and recognizes sequences which overlap with the proposed site of action for AmdA.; Localization: seems to be a nuclear protein.; Title: similarity to zinc-finger transcription factor amdA - Aspergillus nidulans; See PMID 7596297; uncharacterized protein 1265978 4985855 An12g05050 Aspergillus niger uncharacterized protein XP_001395576.3 1263927 D 5061 CDS An12g05060 4985856 complement(1266087..1267607) III 1 NT_166527.1 Function: S. cerevisiae enzyme is a high affinity transporter of nicotinic acid.; Remark: a splice site was detected upstream of the START codon.; Similarity: belongs to the allantoate transporter family.; Title: similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; plasma membrane; See PMID 10649454; See PMID 10869563; uncharacterized protein 1267607 4985856 An12g05060 Aspergillus niger uncharacterized protein XP_001395577.1 1266087 R 5061 CDS An12g05070 4985857 1268118..1268930 III 1 NT_166527.1 Function: the HHED aldolase catalyses the analogous reaction in the catechol meta-fission pathway.; Function: the homoprotocatechuic acid (HPC) pathway is a typical catabolic sequence for converting peripheral metabolites into intermediates of central metabolism.; Similarity: strong similarity at the first 2/3 of the the protein.; Title: similarity to 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase hpcH - Escherichia coli; See PMID 8529896; uncharacterized protein 1268930 4985857 An12g05070 Aspergillus niger uncharacterized protein XP_001395578.1 1268118 D 5061 CDS An12g05080 4985858 complement(join(1269529..1269753,1269816..1269889,1269949..1270000)) III 1 NT_166527.1 Function: might be involved in regulation of translation initiation.; Similarity: predicted protein seems to be highly conserved.; Title: strong similarity to hypothetical translation initiation inhibitor SPAC922.01 - Schizosaccharomyces pombe; uncharacterized protein 1270000 4985858 An12g05080 Aspergillus niger uncharacterized protein XP_001395579.1 1269529 R 5061 CDS An12g05090 4985859 join(1270601..1270846,1270903..1271028,1271085..1271673,1271740..1271984) III 1 NT_166527.1 Function: 1-Aminocyclopropane carboxylase oxidase (ACC oxidase) GEFE-1 (W09880) is an enzyme involved in the biosynthesis of ethylene in plants important for fruit ripening.; Remark: blast hit against protein of patent WO9717429-A1.; Title: similarity to 1-aminocyclopropane-1-carboxylate oxidase GEFE-1 from patent WO9717429-A1 - Pelargonium domesticum; uncharacterized protein 1271984 4985859 An12g05090 Aspergillus niger uncharacterized protein XP_001395580.1 1270601 D 5061 CDS An12g05100 4985860 complement(join(1272153..1272248,1272289..1272346,1272425..1272641,1272733..1273160,1273253..1273308)) III 1 NT_166527.1 Remark: the enzyme of B. subtilis is used in a novel method (patent EP955375-A2) to produce optically active 4-haol-3-hydroxybutyric acid ester, with a high purity.; Similarity: seems to be highly conserved.; Title: strong similarity to 3-oxoacyl-(acyl-carrier-protein) reductase fabG - Bacillus subtilis; See PMID 8759840; uncharacterized protein 1273308 4985860 An12g05100 Aspergillus niger uncharacterized protein XP_059604452.1 1272153 R 5061 CDS An12g05110 4985861 join(1274369..1274413,1274464..1274512,1274561..1276275) III 1 NT_166527.1 Title: strong similarity to hypothetical protein encoded by An15g01870 - Aspergillus niger; uncharacterized protein 1276275 4985861 An12g05110 Aspergillus niger uncharacterized protein XP_059604453.1 1274369 D 5061 CDS An12g05120 4985862 join(1277152..1277584,1277832..1277941,1278009..1278344) III 1 NT_166527.1 Complex: in various organisms, cdc2 has been identified as a component of the M-phase specific histone H1 kinase (maturation-promoting factor, growth-associated H1 kinase) and CTD kinase.; Function: PfPK5 of P. falciparum has kinase activity against casein and histone H1.; Function: PfPK5 of P. falciparum is present in approximately constant amounts throughout the intra-erythrocytic asexual reproductive stage of the life cycle.; Localization: PfPK5 of P. falciparum is located in the parasite's cytosol.; Similarity: shows similarity to the carboxyterminal part of cdc2 and related protein kinases.; Title: similarity to protein kinase cdc2 homolog PfPK5 - Plasmodium falciparum; deleted EC_number 2.7.1.37; uncharacterized protein 1278344 4985862 An12g05120 Aspergillus niger uncharacterized protein XP_059604454.1 1277152 D 5061 CDS An12g05140 84592567 1279134..1280471 III 1 NT_166527.1 Title: weak similarity to hypothetical protein encoded by An15g00660 - Aspergillus niger; uncharacterized protein 1280471 84592567 An12g05140 Aspergillus niger uncharacterized protein XP_059604455.1 1279134 D 5061 CDS An12g05150 4985865 complement(join(1280951..1281393,1281478..1281643,1281722..1281864,1281922..1282118,1282160..1282187,1282230..1282407)) III 1 NT_166527.1 Function: putative dioxygenase.; Similarity: shows similarity to several dioxygenases.; Title: similarity to protein sequence SEQ ID NO:1465 from patent WO200294867-A2 - Photorhabdus luminescens; uncharacterized protein 1282407 4985865 An12g05150 Aspergillus niger uncharacterized protein XP_059604456.1 1280951 R 5061 CDS An12g05160 84592568 join(1282652..1282813,1282860..1282946,1283081..1283144,1283250..1283323,1283410..1283491,1283566..1283640,1283827..1283978) III 1 NT_166527.1 hypothetical protein 1283978 84592568 An12g05160 Aspergillus niger hypothetical protein XP_059604457.1 1282652 D 5061 CDS An12g05170 4985867 complement(join(1284873..1285021,1285128..1285436,1285529..1285958)) III 1 NT_166527.1 Title: similarity to hypothetical protein AAM35689.1 - Xanthomonas axonopodis; uncharacterized protein 1285958 4985867 An12g05170 Aspergillus niger uncharacterized protein XP_001395587.3 1284873 R 5061 CDS An12g05180 4985868 complement(join(1287719..1287748,1287815..1288296,1288362..1288857)) III 1 NT_166527.1 Catalytic activity: CPEP phosphonomutase catalyzes the rearrangement of the carboxyphosphono group of CPEP to form the C-P bond of phosphinopyruvate.; Function: an enzyme catalyzing the formation of an unusual C-P bond that is involved in the biosynthesis of the antibiotic bialaphos (BA) was isolated from the cell extract of a mutant (NP71) of Streptomyces hygroscopicus SF1293.; Title: strong similarity to carboxyphosphonoenolpyruvate phosphonomutase bcpA -Streptomyces hygroscopicus; uncharacterized protein 1288857 4985868 An12g05180 Aspergillus niger uncharacterized protein XP_001395588.1 1287719 R 5061 CDS An12g05190 4985869 join(1289260..1289391,1289433..1289508,1289564..1289735,1289800..1290068,1290129..1290967) III 1 NT_166527.1 Complex: component of the allantoate transport system.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 3275614; See PMID 10869563; uncharacterized protein 1290967 4985869 An12g05190 Aspergillus niger uncharacterized protein XP_059604458.1 1289260 D 5061 CDS An12g05200 4985870 join(1291130..1291443,1291497..1291805,1291862..1292760,1292828..1293549) III 1 NT_166527.1 Function: protein of S. cerevisiae is involved in regulation of aromatic aminotransferase II that catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism.; Localization: although not found in literature,nuclear localization is highly probable.; Similarity: shows similarity to aminoterminal and central part of S. cerevisiae transcription factor.; Title: similarity to transcription factor Aro80 -Saccharomyces cerevisiae; See PMID 10207060; uncharacterized protein 1293549 4985870 An12g05200 Aspergillus niger uncharacterized protein XP_001395590.3 1291130 D 5061 CDS An12g05210 4985871 complement(join(1294352..1295115,1295188..1295478,1295573..1295897)) III 1 NT_166527.1 Function: in lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium.; Function: trout MAO oxidizes both serotonin [5-hydroxytryptamine (5-HT)] and beta-phenylethylamine (PEA).; Title: strong similarity to monoamine oxidase MAO -Oncorhynchus mykiss; See PMID 7808446; uncharacterized protein 1295897 4985871 An12g05210 Aspergillus niger uncharacterized protein XP_059604459.1 1294352 R 5061 CDS An12g05220 4985872 join(1296714..1296763,1296861..1296983,1297053..1297177,1297252..1297991,1298057..1298330,1298387..1298562,1298627..1298807,1298875..1299413) III 1 NT_166527.1 Function: the nmt1+ gene of the fission yeast Schizosaccharomyces pombe is subject to transcriptional repression mediated by thiamine and ntf1+ encodes a 6-cysteine zinc finger-containing transcription factor that regulates the nmt1 promoter.; Similarity: shows only similarity to the amino- and central part of nft1.; Title: similarity to transcription factor nft1p -Schizosaccharomyces pombe; nucleus; See PMID 8163491; uncharacterized protein 1299413 4985872 An12g05220 Aspergillus niger uncharacterized protein XP_059604460.1 1296714 D 5061 CDS An12g05230 84592569 join(1300808..1300906,1300992..1301204) III 1 NT_166527.1 hypothetical protein 1301204 84592569 An12g05230 Aspergillus niger hypothetical protein XP_059604461.1 1300808 D 5061 CDS An12g05240 4985874 join(1302059..1302426,1302499..1303180) III 1 NT_166527.1 Title: weak similarity to RNA polymerase -Paramyxoviridae sp.; uncharacterized protein 1303180 4985874 An12g05240 Aspergillus niger uncharacterized protein XP_001395594.1 1302059 D 5061 CDS An12g05250 4985875 complement(join(1303393..1303968,1304020..1304349)) III 1 NT_166527.1 Similarity: shows only weak similarity to aminoterminal and central part of TH7 protein and also to parts of several patented proteins.; Title: weak similarity to phenylcoumaran benzylic ether reductase homolog TH7 - Tsuga heterophylla; See PMID 10066819; uncharacterized protein 1304349 4985875 An12g05250 Aspergillus niger uncharacterized protein XP_059604462.1 1303393 R 5061 CDS An12g05260 4985876 join(1304845..1305144,1305196..1305290,1305356..1305860) III 1 NT_166527.1 Catalytic activity: hydroxyisoflavone reductases catalyse vestitone + NADP(+) <=> 2'-hydroxyformononetin + NADPH.; Function: hydroxyisoflavone reductases are involved in the biosysthesis of the pterocarpin phytoalexins medicarpin and maachiain, which play a significant role in the defense response of plants.; Similarity: strong similarity to Sequence 17 from Patent EP0845532, which decribes enzymes for the synthesis of coniferyl alcohol, coniferyl aldehyde, ferulic acid,vanillin, vanillic acid and their applications.; Title: similarity to 2-hydroxyisoflavone reductase -Pisum sativum; See PMID 10680168; uncharacterized protein 1305860 4985876 An12g05260 Aspergillus niger uncharacterized protein XP_001395596.1 1304845 D 5061 CDS An12g05270 4985877 join(1306337..1306479,1306545..1306998,1307055..1307627) III 1 NT_166527.1 Remark: only the N-terminal domain of the protein is matching.; Similarity: to Zn(2)-Cys(6) binuclear cluster family.; Title: weak similarity to transcription activator CMR1 - Colletotrichum lagenarium; uncharacterized protein 1307627 4985877 An12g05270 Aspergillus niger uncharacterized protein XP_001395597.1 1306337 D 5061 CDS An12g05280 4985878 1308416..1309372 III 1 NT_166527.1 Remark: esterases are contributing to detoxification of pyrethroid compounds, as a resistant mechanism in Mexican strains of the southern cattle tick.; Title: weak similarity to esterase - Boophilus microplus; See PMID 10899463; uncharacterized protein 1309372 4985878 An12g05280 Aspergillus niger uncharacterized protein XP_001395598.1 1308416 D 5061 CDS An12g05290 84592570 join(1309560..1309667,1309763..1309898,1309992..1310188,1310403..1310576) III 1 NT_166527.1 Title: weak similarity to hypothetical protein encoded by An04g00640 - Aspergillus niger; uncharacterized protein 1310576 84592570 An12g05290 Aspergillus niger uncharacterized protein XP_059604463.1 1309560 D 5061 CDS An12g05300 84592571 join(1310683..1310840,1310923..1311007,1311066..1311297,1311359..1312018,1312101..1312210) III 1 NT_166527.1 hypothetical protein 1312210 84592571 An12g05300 Aspergillus niger hypothetical protein XP_059604464.1 1310683 D 5061 CDS An12g05310 4985881 join(1313220..1313541,1313611..1315262) III 1 NT_166527.1 Remark: possibly involved in the degradation of external UDP-glucose by similarity; Similarity: belongs to 5' nucleotidase family.; Title: strong similarity to hypothetical 5 nucleotidase family protein SPBPB2B2.06c -Schizosaccharomyces pombe; uncharacterized protein 1315262 4985881 An12g05310 Aspergillus niger uncharacterized protein XP_059604465.1 1313220 D 5061 CDS An12g05320 4985882 join(1316859..1317099,1317161..1317438) III 1 NT_166527.1 Title: similarity to hypothetical protein encoded by An09g02090 - Aspergillus niger; uncharacterized protein 1317438 4985882 An12g05320 Aspergillus niger uncharacterized protein XP_001395602.1 1316859 D 5061 CDS An12g05330 84592572 join(1318944..1319430,1319525..1319595,1319648..1319990,1320128..1320658,1320734..1321355,1321465..1321873,1322019..1322399) III 1 NT_166527.1 Catalytic activity: random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins.; Pathway: aminosugars metabolism.; Remark: some chitinases also display lysozyme activity.; Similarity: to protein with hevein chitin-binding domain homology.; Title: strong similarity to RF2 - Candida sphaerica; See PMID 6387625; See PMID 6473099; uncharacterized protein 1322399 84592572 An12g05330 Aspergillus niger uncharacterized protein XP_059604466.1 1318944 D 5061 CDS An12g05350 84592573 complement(join(1323970..1324035,1324118..1324285,1324447..1324516,1324732..1324828,1325276..1325407,1325494..1325625,1325950..1326059,1326309..1326408,1326712..1326864,1327032..1327197)) III 1 NT_166527.1 hypothetical protein 1327197 84592573 An12g05350 Aspergillus niger hypothetical protein XP_059604467.1 1323970 R 5061 CDS An12g05360 4985886 join(1328252..1328639,1328714..1329540,1329622..1330116) III 1 NT_166527.1 Remark: cholesterol 24-hydroxylase is expressed predominantly in the brain as judged by RNA and protein blotting. In situ mRNA hybridization and immunohistochemistry localize the expression of this P450 to neurons in multiple subregions of the brain.; Remark: the turnover of cholesterol in the brain is thought to occur via conversion of excess cholesterol into 24S-hydroxycholesterol, an oxysterol that is readily secreted from the central nervous system into the plasma.; Similarity: belongs to cytochrome P450 family proteins.; Title: strong similarity to cholesterol 24-hydroxylase - Mus musculus; See PMID 10377398; uncharacterized protein 1330116 4985886 An12g05360 Aspergillus niger uncharacterized protein XP_059604468.1 1328252 D 5061 CDS An12g05370 4985887 complement(join(1330616..1330835,1330901..1331442,1331496..1331828,1331888..1332139)) III 1 NT_166527.1 Catalytic activity: s-adenosyl-l-methionine + sterigmatocystin = s-adenosyl-l-homocysteine + 7-o-methylsterigmatocystin.; Pathway: aflatoxin biosynthesis.; Remark: aflatoxins are polyketide-derived secondary metabolites produced by the fungi Aspergillus flavus and Aspergillus parasiticus. Among the catalytic steps in the aflatoxin biosynthetic pathway, the conversion of sterigmatocystin to O-methylsterigmatocystin and the conversion of dihydrosterigmatocystin to dihydro-O-methylsterigmatocystin are catalyzed by an S-adenosylmethionine-dependent O-methyltransferase.; Remark: omtA of A. parasiticus is also called omt-1.; Title: strong similarity to O-methyltransferase A omtA - Aspergillus parasiticus; See PMID 7557460; See PMID 8285664; See PMID 8434913; uncharacterized protein 1332139 4985887 An12g05370 Aspergillus niger uncharacterized protein XP_001395606.3 1330616 R 5061 CDS An12g05380 4985888 join(1332943..1333231,1333328..1333574,1333690..1334059,1334168..1334311,1334424..1334593,1334670..1334767,1334853..1334883,1334953..1335313) III 1 NT_166527.1 Remark: confer resistance to various antibiotics and toxins in fungi and bacteria.; Remark: many species of the fungal genus Cercospora,including the soybean pathogen C. kikuchii, produce the phytotoxic polyketide cercosporin.; Title: strong similarity to cercosporin transporter CFP - Cercospora kikuchii; See PMID 10517030; uncharacterized protein 1335313 4985888 An12g05380 Aspergillus niger uncharacterized protein XP_059604469.1 1332943 D 5061 CDS An12g05390 4985889 complement(join(1335831..1336123,1336221..1336415,1336494..1336580,1336632..1337007,1337159..1337215)) III 1 NT_166527.1 Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea; uncharacterized protein 1337215 4985889 An12g05390 Aspergillus niger uncharacterized protein XP_059604470.1 1335831 R 5061 CDS An12g05400 4985890 join(1337940..1338136,1338187..1338948,1339023..1339546,1339678..1339865) III 1 NT_166527.1 Catalytic activity: cholesterol + NADPH + O2 = 7alpha-hydroxycholesterol + NADP+ + H2O.; Pathway: bile acid biosynthesis.; Remark: cholesterol 7 alpha-hydroxylase, the key enzyme in a series of metabolic changes for the production of bile acids from cholesterol, shows circadian rhythms.; Similarity: belongs to the human cytochrome P450 family.; Title: similarity to cholesterol 7alpha-monooxygenase CYP7 - Oryctolagus cuniculus; See PMID 7751825; uncharacterized protein 1339865 4985890 An12g05400 Aspergillus niger uncharacterized protein XP_001395609.1 1337940 D 5061 CDS An12g05420 4985892 join(1340518..1341300,1341552..1341602) III 1 NT_166527.1 Title: similarity to hypothetical protein encoded by An03g01830 - Aspergillus niger; uncharacterized protein 1341602 4985892 An12g05420 Aspergillus niger uncharacterized protein XP_001395610.3 1340518 D 5061 CDS An12g05430 84592574 join(1342118..1342531,1342573..1342755) III 1 NT_166527.1 Title: similarity to hypothetical protein CAF32108.1 - Aspergillus fumigatus; uncharacterized protein 1342755 84592574 An12g05430 Aspergillus niger uncharacterized protein XP_059604471.1 1342118 D 5061 CDS An12g05440 4985894 complement(join(1343386..1343493,1343569..1344623,1344681..1345107,1345141..1345581)) III 1 NT_166527.1 Induction: by allophanate or its non-metabolized analog oxalurate. Sensitive to nitrogen catabolite repression.; Remark: DUR3 expression in yeast is highly sensitive to nitrogen catabolite repression and also has a partial requirement for the GLN3 product.; Title: strong similarity to urea transport protein Dur3 - Saccharomyces cerevisiae; See PMID 8335627; uncharacterized protein 1345581 4985894 An12g05440 Aspergillus niger uncharacterized protein XP_059604472.1 1343386 R 5061 CDS An12g05450 84592575 complement(join(1346121..1348001,1348060..1348356,1348413..1350947,1351076..1351991,1352052..1352176)) III 1 NT_166527.1 Function: het-6 of N. crassa is involved in the restriction of heterokaryon formation during asexual growth.; Remark: in filamentous fungi, vegetative cell fusion between genotypically distinct individuals leads to a cell-death reaction known as vegetative or heterokaryon incompatibility.; Similarity: het-6(OR) of N. crassa has three regions of amino acid sequence similarity to the predicted product of the het-e vegetative incompatibility gene in P. anserina and to the predicted product of tol, which mediates mating-type vegetative incompatibility in N. crassa.; Title: similarity to heterokaryon incompatibility protein het-6 - Neurospora crassa; See PMID 10880472; See PMID 11035941; See PMID 11092825; uncharacterized protein 1352176 84592575 An12g05450 Aspergillus niger uncharacterized protein XP_059604473.1 1346121 R 5061 CDS An12g05460 4985896 complement(join(1352930..1353732,1353818..1354019,1354087..1354365,1354418..1354524,1354580..1355682,1355735..1356896,1356949..1357134,1357195..1357237)) III 1 NT_166527.1 Catalytic activity: ATP + 5-oxo-L-proline + 2 H2O = ADP + orthophosphate + L-glutamate.; Pathway: 5-OPase of R. norvegicus is involved in glutathione biosynthesis.; Phenotype: deficiency of 5-OPase of R. norvegicus is associated with 5-oxoprolinuria.; Remark: 5-OPase of R. norvegicus belongs to the oxoprolinase family.; Title: strong similarity to 5-oxoprolinase from patent WO9825945-A1 - Rattus norvegicus; See PMID 8943290; See PMID 9516961; See PMID 9751079; uncharacterized protein 1357237 4985896 An12g05460 Aspergillus niger uncharacterized protein XP_059604474.1 1352930 R 5061 CDS An12g05470 4985897 complement(join(1357551..1358022,1358194..1358432,1358482..1358625,1358653..1359018)) III 1 NT_166527.1 Similarity: the ORF shows strong local similarity to yraM of B. subtilis along the N-terminal half.; Title: strong similarity to hypothetical protein yraM - Bacillus subtilis; uncharacterized protein 1359018 4985897 An12g05470 Aspergillus niger uncharacterized protein XP_059604475.1 1357551 R 5061 CDS An12g05490 4985899 join(1360578..1360637,1360691..1361206,1361306..1361395,1361443..1361575,1361669..1362189,1362317..1362376) III 1 NT_166527.1 Similarity: the N-terminus of the ORF shows strong similarity to several other proteins including transcription factors.; Title: similarity to hypothetical protein encoded by An01g03400 - Aspergillus niger; uncharacterized protein 1362376 4985899 An12g05490 Aspergillus niger uncharacterized protein XP_059604476.1 1360578 D 5061 CDS An12g05500 4985900 complement(join(1362655..1362942,1363010..1363128,1363192..1363410,1363485..1363782)) III 1 NT_166527.1 Function: dsk1 of S. pombe plays a role in the regulation of chromosome segregation at the metaphase/anaphase transition.; Function: recently, it was found that dsk1 of S. pombe also functions as a kinase specific for SR proteins,a family of pre-mRNA splicing factors containing arginine-serine repeats, and is thus presumably involved in pre-mRNA splicing.; Remark: dsk1 (dis1-suppressing protein kinase) of S. pombe is also called SPBC530. 14C.; Similarity: the ORF is shorter than dsk1 of S. pombe (307 compared to 455 amino acids).; Similarity: the ORF shows local strong similarity to dsk1 of S. pombe over two stretches of ca. 100 and ca. 60 amino acids.; Title: similarity to protein kinase dsk1p -Schizosaccharomyces pombe; See PMID 9488736; See PMID 10629038; uncharacterized protein 1363782 4985900 An12g05500 Aspergillus niger uncharacterized protein XP_001395617.3 1362655 R 5061 CDS An12g05510 4985901 complement(join(1364516..1365450,1365512..1366125,1366179..1366417)) III 1 NT_166527.1 Function: TAF1 of S. cerevisiae encodes a transporter for the fungal siderophore triacetylfusarinine C.; Phenotype: disruption of TAF1 of S. cerevisiae leads to yeast cells unable to take up and utilize iron from triacetylfusarinine C und fusigen.; Remark: TAF1 is also called ARN2 or YHL047c.; Remark: siderophores (e. g. ferrioxamine B,ferrichrome, triacetylfusarinine C and ferricrocin) are iron chelators and are used by bacteria to bind extracellular iron. After iron binding they are recognized by membrane proteins such as TAF1 and the bound iron is internalized.; Title: strong similarity to triacetylfusarinine C transporter Taf1 - Saccharomyces cerevisiae; plasma membrane; See PMID 10816729; See PMID 11158346; See PMID 2531838; uncharacterized protein 1366417 4985901 An12g05510 Aspergillus niger uncharacterized protein XP_001395618.1 1364516 R 5061 CDS An12g05520 84592576 join(1366698..1366771,1366856..1366896,1367150..1367571) III 1 NT_166527.1 Remark: the ORF has an unusual exon/intron structure for A. niger.; hypothetical protein 1367571 84592576 An12g05520 Aspergillus niger hypothetical protein XP_059604477.1 1366698 D 5061 CDS An12g05530 84592577 join(1368408..1368513,1368621..1368758,1368841..1368900,1368985..1369115) III 1 NT_166527.1 Remark: the ORF has an unusual exon/intron structure for A. niger.; hypothetical protein 1369115 84592577 An12g05530 Aspergillus niger hypothetical protein XP_059604478.1 1368408 D 5061 CDS An12g05540 84592578 join(1369361..1369620,1369685..1369823) III 1 NT_166527.1 hypothetical protein 1369823 84592578 An12g05540 Aspergillus niger hypothetical protein XP_059604479.1 1369361 D 5061 CDS An12g05550 84592579 complement(join(1370233..1370603,1370659..1370887,1370949..1371149)) III 1 NT_166527.1 hypothetical protein 1371149 84592579 An12g05550 Aspergillus niger hypothetical protein XP_059604480.1 1370233 R 5061 CDS An12g05570 4985907 join(1372516..1372635,1372684..1373669,1373730..1373922) III 1 NT_166527.1 Function: faoA of A. terreus is an FAD-binding oxidoreductase, which deglycates glycated compounds like N-epsilon-fructosyl N-sigma-Z-lysine and N-fructosyl valine, oxidatively into free fructosamine.; Title: strong similarity to fructosyl amino acid oxidase faoA - Aspergillus terreus; See PMID 9022674; uncharacterized protein 1373922 4985907 An12g05570 Aspergillus niger uncharacterized protein XP_001395623.1 1372516 D 5061 CDS An12g05580 4985908 join(1374972..1375203,1375254..1376566) III 1 NT_166527.1 Remark: the ORF is shorter than SPBC530. 11c of S. pombe (514 compared to 819 amino acids).; Similarity: the ORF shows local similarity to SPBC530. 11c of S. pombe over a stretch of 260 amino acids.; Title: weak similarity to hypothetical transcriptional regulator SPBC530.11c - Schizosaccharomyces pombe; uncharacterized protein 1376566 4985908 An12g05580 Aspergillus niger uncharacterized protein XP_001395624.3 1374972 D 5061 CDS An12g05590 4985909 complement(1376859..1378517) III 1 NT_166527.1 Catalytic activity: B. subtilis pnbA catalyzes hydrolysis of several beta-lactam antibiotic PNB esters to the corresponding free acids and PNB alcohols.; Title: strong similarity to p-nitrobenzyl esterase pnbA - Bacillus subtilis; See PMID 7828905; uncharacterized protein 1378517 4985909 An12g05590 Aspergillus niger uncharacterized protein XP_001395625.1 1376859 R 5061 CDS An12g05600 4985910 join(1381619..1381668,1381840..1383562) III 1 NT_166527.1 Function: het-6 of N. crassa is involved in the restriction of heterokaryon formation during asexual growth.; Remark: in filamentous fungi, vegetative cell fusion between genotypically distinct individuals leads to a cell-death reaction known as vegetative or heterokaryon incompatibility.; Similarity: het-6(OR) of N. crassa has three regions of amino acid sequence similarity to the predicted product of the het-e vegetative incompatibility gene in P. anserina and to the predicted product of tol, which mediates mating-type vegetative incompatibility in N. crassa.; Similarity: the ORF is about 100 amino acids shorter than het-6 of N. crassa.; Title: similarity to heterokaryon incompatibility protein het-6 - Neurospora crassa; See PMID 10880472; See PMID 11035941; See PMID 11092825; uncharacterized protein 1383562 4985910 An12g05600 Aspergillus niger uncharacterized protein XP_059604481.1 1381619 D 5061 CDS An12g05610 4985911 join(1384337..1384793,1384848..1385039,1385092..1385480,1385546..1385962) III 1 NT_166527.1 Function: mtr of N. crassa is required for the transport of neutral aliphatic and aromatic amino acids via the N system and belongs to the Amino Acid/Auxin Permease (AAAP)family (TC 2. A. 42).; Remark: mtr is a short cut for methyltryptophan resistance (protein).; Title: strong similarity to neutral amino acid permease mtr from patent WO9325663-A - Neurospora crassa; plasma membrane; See PMID 8001794; See PMID 1838345; uncharacterized protein 1385962 4985911 An12g05610 Aspergillus niger uncharacterized protein XP_059604482.1 1384337 D 5061 CDS An12g05630 4985913 1387791..1389194 III 1 NT_166527.1 Function: TRI101 of F. sporotrichioides confers resistance to the trichothecene 4,15-diacetoxyscirpenol.; Function: TRI101 of F. sporotrichioides converts isotrichodermol to isotrichodermin and is required for the biosynthesis of the trichothecene T-2 toxin.; Phenotype: mutation of TRI101 of F. sporotrichioides leads to abolished synthesis of T-2 toxin and to accumulation of isotrichodermol.; Remark: fungi protect themselves from their own toxins by e. g. modification of the toxins.; Remark: trichothecenes are mycotoxins and act as potent inhibitors of eukaryotic protein synthesis.; Title: similarity to trichothecene 3-O-acetyltransferase TRI101 - Fusarium sporotrichioides; See PMID 10583973; See PMID 10960733; uncharacterized protein 1389194 4985913 An12g05630 Aspergillus niger uncharacterized protein XP_001395628.1 1387791 D 5061 CDS An12g05640 4985914 complement(1389634..1390728) III 1 NT_166527.1 Similarity: the ORF is much shorter than Y57A10A. p of C. elegans (364 compared to 1718 amino acids).; Title: weak similarity to hypothetical protein Y57A10A.p - Caenorhabditis elegans; uncharacterized protein 1390728 4985914 An12g05640 Aspergillus niger uncharacterized protein XP_001395629.1 1389634 R 5061 CDS An12g05650 4985915 join(1392048..1393065,1393115..1393934,1393983..1397095,1397174..1398081) III 1 NT_166527.1 Function: ankyrins serve as linkers between the spectrin-based cytoskeleton and integral membrane protein.; Localization: ank3 of M. musculus is plasma-membrane associated.; Remark: the ORF shows local similarity to ank3 of M. musculus (about 500 C-terminal amino acid of the ORF are aligned with ank3); the ank motifs are included in the alignment between the two proteins.; Title: strong similarity to ankyrin 3 Ank3 - Mus musculus; See PMID 7615634; See PMID 10810176; uncharacterized protein 1398081 4985915 An12g05650 Aspergillus niger uncharacterized protein XP_059604483.1 1392048 D 5061 CDS An12g05660 4985916 complement(join(1398463..1398879,1398931..1399074)) III 1 NT_166527.1 Title: similarity to hypothetical protein encoded by An12g02830 - Aspergillus niger; uncharacterized protein 1399074 4985916 An12g05660 Aspergillus niger uncharacterized protein XP_059604484.1 1398463 R 5061 CDS An12g05670 4985917 join(1399487..1399577,1399645..1402619) III 1 NT_166527.1 Title: similarity to protein fragment SEQ ID NO:19345 from patent EP1033405-A2 - Arabidopsis thaliana [putative frameshift]; putative frameshift; uncharacterized protein 1402619 4985917 An12g05670 Aspergillus niger uncharacterized protein XP_059604485.1 1399487 D 5061 CDS An12g05680 4985918 complement(join(1402918..1406055,1406116..1406622)) III 1 NT_166527.1 Function: ANK1 is a cytoskeleton component and generates the p57 membrane proteinase which cleaves C3, the third component of complement.; Title: similarity to erythrocyte splice form 1 of ankyrin ANK1 - Homo sapiens; plasma membrane; See PMID 7526850; See PMID 2141335; uncharacterized protein 1406622 4985918 An12g05680 Aspergillus niger uncharacterized protein XP_001395633.3 1402918 R 5061 CDS An12g05690 84592580 join(1406933..1407046,1407421..1407595,1407647..1407690,1407774..1407823,1407896..1407991,1408081..1408122,1408205..1408250) III 1 NT_166527.1 hypothetical protein 1408250 84592580 An12g05690 Aspergillus niger hypothetical protein XP_059604486.1 1406933 D 5061 CDS An12g05700 4985920 join(1409244..1409304,1409347..1410570,1410642..1411855) III 1 NT_166527.1 Catalytic activity: RhaA is able to hydrolyze alpha-1,2 and alpha-1,6 linkages to beta-D-glucosides.; Title: similarity to alpha-L-rhamnosidase A precursor rhaA - Aspergillus aculeatus; See PMID 11319105; uncharacterized protein 1411855 4985920 An12g05700 Aspergillus niger uncharacterized protein XP_059604487.1 1409244 D 5061 CDS An12g05710 4985921 join(1412454..1412544,1412604..1412805,1412858..1413402,1413465..1413661,1413722..1414093) III 1 NT_166527.1 Catalytic activity: fucP has L-fucose-H+ symport activity.; Function: fucP mediates the transport of L-Fucose (6-deoxy-L-galactose) into Escherichia coli.; Title: strong similarity to L-fucose permease fucP -Escherichia coli; plasma membrane; See PMID 8052131; uncharacterized protein 1414093 4985921 An12g05710 Aspergillus niger uncharacterized protein XP_059604488.1 1412454 D 5061 CDS An12g05720 4985922 join(1415374..1415846,1415901..>1416701) III 1 NT_166527.1 Pathway: heml is involved in porphyrin and chlorophyll metabolism.; Remark: Deletion of heml does not ablate heme biosynthesis.; Remark: the Bacillus subtilis hemAXCDBL gene cluster encodes enzymes of the biosynthetic pathway from glutamate to uroporphyrinogen III.; Title: strong similarity to glutamate-1-semialdehyde 2,1-aminomutase hemL - Bacillus subtilis [putative frameshift]; putative frameshift; See PMID 1672867; uncharacterized protein 1416701 4985922 An12g05720 Aspergillus niger uncharacterized protein XP_059604489.1 1415374 D 5061 CDS An12g05730 4985923 join(1417583..1417676,1417789..1418036,1418092..1418185,1418244..1418316,1418368..1418503) III 1 NT_166527.1 Title: weak similarity to hypothetical protein encoded by An08g11010 - Aspergillus niger; uncharacterized protein 1418503 4985923 An12g05730 Aspergillus niger uncharacterized protein XP_059604490.1 1417583 D 5061 CDS An12g05740 4985924 complement(join(1419114..1419599,1419654..1419803,1419850..1420164,1420321..1420860,1420906..1420959)) III 1 NT_166527.1 Title: strong similarity to hypothetical protein EAA70268.1 - Gibberella zeae; uncharacterized protein 1420959 4985924 An12g05740 Aspergillus niger uncharacterized protein XP_059604491.1 1419114 R 5061 CDS An12g05750 4985925 complement(join(1422472..1423790,1423867..1424187,1424252..1424549)) III 1 NT_166527.1 Function: PHO84 is a high-affinity inorganic phosphate/H+ symporter.; Induction: PHO84 transcription is regulated by Pi.; Phenotype: disruption of PHO84 is not lethal.; Title: strong similarity to high-affinity inorganic phosphate/H+ symporter Pho84 - Saccharomyces cerevisiae; plasma membrane; See PMID 10518922; See PMID 2038328; uncharacterized protein 1424549 4985925 An12g05750 Aspergillus niger uncharacterized protein XP_059604492.1 1422472 R 5061 CDS An12g05760 84592581 join(1424627..1424648,1424734..1424866,1424970..1425249) III 1 NT_166527.1 hypothetical protein 1425249 84592581 An12g05760 Aspergillus niger hypothetical protein XP_059604493.1 1424627 D 5061 CDS An12g05770 84592582 complement(join(1425370..1425567,1425701..1425964)) III 1 NT_166527.1 hypothetical protein 1425964 84592582 An12g05770 Aspergillus niger hypothetical protein XP_059604494.1 1425370 R 5061 CDS An12g05780 84592583 join(1426604..1426637,1426674..1426735,1426804..1426818) III 1 NT_166527.1 Title: questionable ORF; uncharacterized protein 1426818 84592583 An12g05780 Aspergillus niger uncharacterized protein XP_059604495.1 1426604 D 5061 CDS An12g05790 84592584 complement(join(1429080..1429136,1429238..1429276)) III 1 NT_166527.1 Title: questionable ORF; uncharacterized protein 1429276 84592584 An12g05790 Aspergillus niger uncharacterized protein XP_059604496.1 1429080 R 5061 CDS An12g05800 84592585 complement(1429760..1429861) III 1 NT_166527.1 Title: questionable ORF; uncharacterized protein 1429861 84592585 An12g05800 Aspergillus niger uncharacterized protein XP_059604497.1 1429760 R 5061 CDS An12g05810 4985931 join(1437880..1438224,1438281..1438389,1438445..1438468,1438519..1438763,1438822..1438906,1438963..1439018,1439072..1439216,1439267..1439853,1439948..1440370) III 1 NT_166527.1 Catalytic activity: laccases convert 4 benzenediol + O(2) <=> 4 benzosemiquinone + 2 H(2)O.; Function: laccase (urishiol oxidase) is an multi-copper enzyme found in fungi and plants with low specificity on both catechol and p-benzenediol, which oxidizes many different types of phenols and diamines.; Function: laccase of C. parasitica is involved in the lignin degradation an detoxification of lignin-derived products.; Induction: copper is needed as cofactor.; Remark: the A. nidulans homologue of the ORF encodes a dihydrogeodin oxidase, that catalyzes the regio- and stereospecific phenol oxidative coupling reaction to form (+)-geodin from dihydrogeodin.; Similarity: shows similarity to several laccases,phenol oxidases of different organisms.; Title: strong similarity to laccase - Cryphonectria parasitica; See PMID 3032923; See PMID 7665560; See PMID 1535523; uncharacterized protein 1440370 4985931 An12g05810 Aspergillus niger uncharacterized protein XP_001395646.1 1437880 D 5061 CDS An12g05820 4985932 complement(join(1440624..1441754,1441831..1442082,1442208..1442324)) III 1 NT_166527.1 Phenotype: HGT1 disruption strains show much-reduced uptake of glucose at low concentrations and growth are particularly affected in low-glucose medium.; Similarity: HGT1 belongs to the sugar transporter family.; Title: strong similarity to high-affinity glucose transporter HGT1 - Kluyveromyces lactis; plasma membrane; See PMID 8830679; uncharacterized protein 1442324 4985932 An12g05820 Aspergillus niger uncharacterized protein XP_001395647.3 1440624 R 5061 CDS An12g05830 4985933 join(1443721..1443800,1443856..1445572) III 1 NT_166527.1 Title: weak similarity to transcription regulator PRO1 - Sordaria macrospora; uncharacterized protein 1445572 4985933 An12g05830 Aspergillus niger uncharacterized protein XP_059604498.1 1443721 D 5061 CDS An12g05840 4985934 join(1446317..1447244,1447300..1448535,1448664..1448759,1448920..>1450009) III 1 NT_166527.1 Function: E1 is involved in lipid metabolism and in the detoxification of xenobiotics.; Remark: possible sequencing error at position 51887,2 bp too much.; Title: similarity to precursor of liver carboxylesterase E1 - Rattus norvegicus [putative frameshift]; endoplasmatic reticulum; putative frameshift; See PMID 2973315; See PMID 3235453; See PMID 8006016; uncharacterized protein 1450009 4985934 An12g05840 Aspergillus niger uncharacterized protein XP_059604499.1 1446317 D 5061 CDS An12g05850 84592586 join(1451082..1451304,1451387..1451424) III 1 NT_166527.1 hypothetical protein 1451424 84592586 An12g05850 Aspergillus niger hypothetical protein XP_059604500.1 1451082 D 5061 CDS An12g05870 4985937 complement(join(1452015..1452444,1452506..1453025,1453094..1453136)) III 1 NT_166527.1 Induction: mmsR has been identified as a member of the XylS/AraC family of transcriptional regulators and appears to act as a positive regulator of the mmsAB operon.; Remark: mmsB belongs to the mmsAB operon of Pseudomonas aeruginosa PAO containing two structural genes involved in valine metabolism.; Title: similarity to 3-hydroxyisobutyrate dehydrogenase mmsB - Pseudomonas aeruginosa; See PMID 1339433; uncharacterized protein 1453136 4985937 An12g05870 Aspergillus niger uncharacterized protein XP_001395651.1 1452015 R 5061 CDS An12g05880 84592587 complement(join(1454360..1454497,1454550..1454675)) III 1 NT_166527.1 hypothetical protein 1454675 84592587 An12g05880 Aspergillus niger hypothetical protein XP_059604501.1 1454360 R 5061 CDS An12g05890 4985939 complement(1455899..1457065) III 1 NT_166527.1 Title: weak similarity to outer spore coat protein cotB - Bacillus subtilis; uncharacterized protein 1457065 4985939 An12g05890 Aspergillus niger uncharacterized protein XP_059604502.1 1455899 R 5061 CDS An12g05900 4985940 complement(1458090..1459199) III 1 NT_166527.1 Remark: Prt1 activity is inhibited by phenanthroline, suggesting that it is a metalloprotease.; Title: strong similarity to extracellular metalloproteinase precursor Prt1 - Erwinia carotovora; extracellular/secretion proteins; See PMID 1917878; uncharacterized protein 1459199 4985940 An12g05900 Aspergillus niger uncharacterized protein XP_001395654.1 1458090 R 5061 CDS An12g05910 84592588 complement(join(1459904..1459971,1460114..1460504)) III 1 NT_166527.1 hypothetical protein 1460504 84592588 An12g05910 Aspergillus niger hypothetical protein XP_059604503.1 1459904 R 5061 CDS An12g05920 84592589 join(1461623..1461855,1461912..1462140,1462200..1462541) III 1 NT_166527.1 Title: weak similarity to negative regulatory protein Hex2 - Saccharomyces cerevisiae; uncharacterized protein 1462541 84592589 An12g05920 Aspergillus niger uncharacterized protein XP_059604504.1 1461623 D 5061 CDS An12g05930 4985943 complement(join(1462993..1463787,1463861..1464625,1464661..1464711)) III 1 NT_166527.1 Title: similarity to hypothetical protein SPCC970.02 - Schizosaccharomyces pombe; uncharacterized protein 1464711 4985943 An12g05930 Aspergillus niger uncharacterized protein XP_059604505.1 1462993 R 5061 CDS An12g05940 84592590 join(1464970..1465033,1465127..1465215,1465298..1465405) III 1 NT_166527.1 hypothetical protein 1465405 84592590 An12g05940 Aspergillus niger hypothetical protein XP_059604506.1 1464970 D 5061 CDS An12g05950 4985945 complement(join(1465730..1467017,1467049..1467530)) III 1 NT_166527.1 Similarity: the central part produces deliberate homology matches with a variety of serine/threonine-rich glycoproteins.; Title: weak similarity to hypothetical protein YMR317w - Saccharomyces cerevisiae; uncharacterized protein 1467530 4985945 An12g05950 Aspergillus niger uncharacterized protein XP_001395659.3 1465730 R 5061 CDS An12g05960 4985946 1468339..1470048 III 1 NT_166527.1 Catalytic activity: DPPII of R. norvegicus hydrolyzes the peptide bond between the second and third amino acid residue of oligo- and polypeptides,preferentially those following a proline residue.; Complex: DPPII of R. norvegicus probably forms a homodimer by means of a leucine zipper motif.; Function: DPPII of R. norvegicus is involved in the degradation of some oligopeptides or their fragments, such as substance P, casomorphin, bradykinin and thyroliberin.; Similarity: DPPII of R. norvegicus belongs to the serine protease superfamily.; Similarity: DPPII of R. norvegicus shares strong homology with human quiescent cells proline dipeptidase QPP.; Similarity: shows also strong similarity to the Haem 84-1 portion of H. contortus 55A surface protein of patent GENESEQPROT:R12098.; Similarity: the 3'-part of the ORF shows strong similarity to a 3'-EST of the A. niger cDNA clone 0418 (EMBLEST:BE760748).; Title: strong similarity to dipeptidyl peptidase II DPPII - Rattus norvegicus; lysosome; See PMID 11139392; See PMID 11173530; uncharacterized protein 1470048 4985946 An12g05960 Aspergillus niger uncharacterized protein XP_001395660.1 1468339 D 5061 CDS An12g05970 4985947 complement(join(1470198..1470483,1470548..1471357,1471419..1471570)) III 1 NT_166527.1 Catalytic activity: NahW of P. stutzeri is a NADH-dependent monooxygenase that catalyzes the conversion of salicylate to catechol.; Function: NahW of P. stutzeri is an isoenzyme of the NahG salicylate hydroxylase.; Pathway: NahW of P. stutzeri is involved in the metabolization of naphtalene and salicylates (lower naphtalene degradation pathway).; Title: strong similarity to salicylate hydroxylase nahW - Pseudomonas stutzeri; See PMID 10197990; uncharacterized protein 1471570 4985947 An12g05970 Aspergillus niger uncharacterized protein XP_001395661.1 1470198 R 5061 CDS An12g05980 84592591 complement(join(1471918..1472198,1472296..1472410)) III 1 NT_166527.1 hypothetical protein 1472410 84592591 An12g05980 Aspergillus niger hypothetical protein XP_059604507.1 1471918 R 5061 CDS An12g05990 4985949 join(1472490..1472612,1472663..1472804,1472858..1473948) III 1 NT_166527.1 Similarity: the central part also shares similarity with the serine/threonine-rich domain of the cell wall maintanance and heat response related protein WSC2 of S. cerevisiae.; Title: weak similarity to hypothetical protein AAA19110.1 - Pichia angusta; uncharacterized protein 1473948 4985949 An12g05990 Aspergillus niger uncharacterized protein XP_001395663.1 1472490 D 5061 CDS An12g06000 4985950 complement(join(1474067..1474269,1474324..1474348,1474411..1474500,1474671..1474739)) III 1 NT_166527.1 hypothetical protein 1474739 4985950 An12g06000 Aspergillus niger hypothetical protein XP_001395664.1 1474067 R 5061 CDS An12g06010 4985951 complement(join(<1475450..1475669,1475723..1476390,1476455..1476595,1476689..1476776,1476880..1476936)) III 1 NT_166527.1 Catalytic activity: PAO of Z. mays catalyzes the FAD-dependent oxidation of secondary amino groups of spermidine and spermine and their acetyl derivatives,thereby producing hydrogen peroxide.; Function: PAO in Z. mays plays an impotant role in the homeostasis of polyamines which are involved in cell growth and differentiation.; Localization: plant PAOs are predominantly localised in the cell wall.; Pathway: PAO of Zea mays is a key enzyme in the polyamine catabolism.; Remark: possible frameshift at position 10905.; Title: strong similarity to polyamine oxidase PAO -Zea mays [putative frameshift]; putative frameshift; See PMID 9598979; See PMID 11164591; uncharacterized protein 1476936 4985951 An12g06010 Aspergillus niger uncharacterized protein XP_001395665.3 1475450 R 5061 CDS An12g06030 4985953 complement(1478123..1479235) III 1 NT_166527.1 Catalytic activity: sulfite oxidase of G. gallus catalyzes the reaction 'sulfite + H2O + O2 = sulfate + H2O2'.; Complex: sulfite oxidase of G. gallus is a homodimer.; Function: sulfite oxidase of G. gallus contains a cytochrome b-like heme-binding domain and a molybdopterin-binding domain.; Function: the catalytic activity of sulfite oxidase of G. gallus requires molybdenum.; Localization: sulfite oxidase of G. gallus is localized to the mitochondrial intermembrane space.; Pathway: sulfite oxidase of G. gallus catalyzes the conversion of sulfite to sulfate, the terminal step in the oxidative degradation of cysteine and methionine.; Remark: in the presence of cytochrome c sulfite oxidase of G. gallus transfers the electrons on cytochrom c and not on oxygen.; Similarity: the A. niger protein also shows strong similarity to various bacterial sulfite dehydrogenases (EC 1. 8. 2. 1) involved in lithotrophic sulfur oxidation.; Title: strong similarity to sulfite oxidase - Gallus gallus; localisation:mitochondrion; See PMID 510290; See PMID 2687265; See PMID 9428520; uncharacterized protein 1479235 4985953 An12g06030 Aspergillus niger uncharacterized protein XP_001395666.3 1478123 R 5061 CDS An12g06040 84592592 join(1479497..1479625,1479678..1479719,1479777..1480033,1480081..1480226,1480281..1480489,1480542..1480624,1480684..1481074) III 1 NT_166527.1 Catalytic activity: ACC synthase catalyzes the reaction 'S-adenosylmethionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine'.; Function: ACC synthase is a critical regulatory enzyme for ethylene dependent development processes such as fruit ripening and flower senescence and response to various environmental stimuli.; Function: ACC synthase requires pyridoxal phosphate as a prosthetic group.; Pathway: ACC synthase is the key enzyme in the biosynthesis of the plant hormone ethylene.; Remark: possible sequence error leading to a premature STOP at position 15543.; Similarity: the A. niger gene shows strong similarity to the protein patent database entry GENESEQPROT:W57484.; Title: strong similarity to 1-aminocyclopropane-1-carboxylic acid synthase from patent US5767376-A - Carica papaya [putative sequencing error]; putative sequencing error; See PMID 9449850; See PMID 10889246; See PMID 7891663; uncharacterized protein 1481074 84592592 An12g06040 Aspergillus niger uncharacterized protein XP_059604508.1 1479497 D 5061 CDS An12g06050 4985955 complement(join(1481582..1481623,1481678..1481948,1482005..1482200,1482250..1482291,1482349..1482680,1482734..1482753,1482809..1483075,1483141..1483527)) III 1 NT_166527.1 Function: Flr1p of S. cerevisiae confers resistance to various antibiotics including fluconazole, diazaborine,cerulenin, benomyl and methotrexate.; Function: Flr1p of S. cerevisiae participates in the Yap1p-mediated oxidative stress response.; Induction: FLR1 expression in S. cerevisiae is transcriptionally activated by the bZip transcription factor Yap1p.; Remark: the systematic name of FLR1 of S. cerevisiae is YBR008c.; Similarity: FLR1 of S. cerevisiae belongs to the major facilitator superfamily.; Title: strong similarity to fluconazole resistance transporter Flr1 - Saccharomyces cerevisiae; plasma membrane; See PMID 10102370; See PMID 10572257; See PMID 10903515; See PMID 11056165; uncharacterized protein 1483527 4985955 An12g06050 Aspergillus niger uncharacterized protein XP_001395668.1 1481582 R 5061 CDS An12g06060 4985956 join(1484146..1484605,1484642..1484919) III 1 NT_166527.1 Title: similarity to hypothetical protein AAK28431.1 - Streptococcus gordonii; uncharacterized protein 1484919 4985956 An12g06060 Aspergillus niger uncharacterized protein XP_059604509.1 1484146 D 5061 CDS An12g06070 4985957 complement(join(1485336..1485899,1485939..1486667)) III 1 NT_166527.1 Function: AflR in A. flavus is required for the expression of the nor1 and ver1 genes.; Pathway: AflR in A. flavus is involved in the regulation of aflatoxin biosynthesis.; Similarity: AflR of A. flavus encodes a putative transcription factor containing a Zn(2)-Cys(6) fungal-type binuclear cluster domain.; Similarity: the homology is limited to the N-terminus containing the Zn(2)-Cys(6) fungal-type binuclear cluster domain.; Title: similarity to aflatoxin biosynthesis regulator aflR - Aspergillus flavus; See PMID 8074521; uncharacterized protein 1486667 4985957 An12g06070 Aspergillus niger uncharacterized protein XP_059604510.1 1485336 R 5061 CDS An12g06080 84592593 join(1488740..1488799,1488911..1488999,1489092..1489472,1489612..1489765,1490092..1490181) III 1 NT_166527.1 hypothetical protein 1490181 84592593 An12g06080 Aspergillus niger hypothetical protein XP_059604511.1 1488740 D 5061 CDS An12g06090 84592594 join(1490810..1490871,1491087..1491357) III 1 NT_166527.1 Title: similarity to hypothetical 12.8K protein G3L - Vaccinia virus; uncharacterized protein 1491357 84592594 An12g06090 Aspergillus niger uncharacterized protein XP_059604512.1 1490810 D 5061 CDS An12g06100 84592595 complement(join(1492193..1492228,1492297..1492531,1492587..1492726,1492815..1492907,1493015..1493350)) III 1 NT_166527.1 Similarity: also shows weak similarity to the N-terminal part of human dentatorubral-pallidoluysian atrophy protein DRPLA (atrophin-1).; Title: weak similarity to hypothetical precursor of extensin - Lycopersicon esculentum; uncharacterized protein 1493350 84592595 An12g06100 Aspergillus niger uncharacterized protein XP_059604513.1 1492193 R 5061 CDS An12g06110 84592596 complement(join(1494200..1494568,1494652..1494939)) III 1 NT_166527.1 Title: similarity to hypothetical protein encoded by An03g04820 - Aspergillus niger; uncharacterized protein 1494939 84592596 An12g06110 Aspergillus niger uncharacterized protein XP_059604514.1 1494200 R 5061 CDS An12g06120 84592597 complement(join(1496017..1496142,1496321..1496454,1496552..1496788,1497050..1497437)) III 1 NT_166527.1 Similarity: AAB98428. 1 of M. jannaschii is a homolog of the conserved hypothetical protein HI0902 from Haemophilus influenzae.; Title: weak similarity to hypothetical protein AAB98428.1 - Methanococcus jannaschii; uncharacterized protein 1497437 84592597 An12g06120 Aspergillus niger uncharacterized protein XP_059604515.1 1496017 R 5061 CDS An12g06130 4985963 1497915..1498985 III 1 NT_166527.1 Title: similarity to glutamyl endoprotease polypeptide from patent WO200268623-A2 - Aspergillus niger; uncharacterized protein 1498985 4985963 An12g06130 Aspergillus niger uncharacterized protein XP_001395676.3 1497915 D 5061 CDS An12g06140 84592598 complement(1500158..>1500484) III 1 NT_166527.1 Remark: the ORF is N-terminally truncated due to the end of the contig.; Similarity: the N-terminal part of the truncated ORF produces deliberate homology matches to a variety of proline-rich proteins from diverse species.; Title: similarity to hypothetical protein encoded by An16g07930 - Aspergillus niger [truncated ORF]; uncharacterized protein 1500484 84592598 An12g06140 Aspergillus niger uncharacterized protein XP_059604516.1 1500158 R 5061 CDS An12g06147 84592599 join(1501457..1501478,1501625..1502103) III 1 NT_166527.1 hypothetical protein 1502103 84592599 An12g06147 Aspergillus niger hypothetical protein XP_059601839.1 1501457 D 5061 CDS An12g06150 84592600 join(1502229..1502265,1502345..1502601,1502853..1503000,1503064..1503120,1503177..1503631) III 1 NT_166527.1 hypothetical protein 1503631 84592600 An12g06150 Aspergillus niger hypothetical protein XP_059601840.1 1502229 D 5061 CDS An12g06160 84592601 complement(join(1504864..1505269,1505387..1505468,1505525..1505556,1505661..1505770)) III 1 NT_166527.1 hypothetical protein 1505770 84592601 An12g06160 Aspergillus niger hypothetical protein XP_059601841.1 1504864 R 5061 CDS An12g06170 84592602 join(1505956..1506188,1506238..1506355) III 1 NT_166527.1 hypothetical protein 1506355 84592602 An12g06170 Aspergillus niger hypothetical protein XP_059601842.1 1505956 D 5061 CDS An12g06180 4985969 1506522..1507673 III 1 NT_166527.1 Catalytic activity: GnT-IV generates the beta-1,4-glycosidic bond between a N-acetylglucosamin moiety (from GlcNAc-UDP) and the alpha-1,3-linked Mannose residiue of the biantennary core structure of N-glycans (Man3GlcNAc2-Asn).; Function: GnT-IV is one of the essential enzymes in the production of tri- and tetra-antennary Asn-linked sugar chains.; Function: MGAT4B of H. sapiens has GnT-IV enzymatic activity.; Title: weak similarity to isoenzyme B of UDP-N-acetylglucosamine:alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV MGAT4B - Homo sapiens; See PMID 10372966; See PMID 9278430; See PMID 9565571; uncharacterized protein 1507673 4985969 An12g06180 Aspergillus niger uncharacterized protein XP_001395682.1 1506522 D 5061 CDS An12g06190 4985970 complement(join(1509744..1510610,1510660..1510728,1510785..1510823,1510880..1511420,1511474..1511838,1511910..1511955,1512019..1512062)) III 1 NT_166527.1 Function: acu-15 in N. crassa is involved in the regulation of acetate induction.; Similarity: the similarity is restricted to the N-terminal part.; Title: weak similarity to transcription activator acu-15 - Neurospora crassa; uncharacterized protein 1512062 4985970 An12g06190 Aspergillus niger uncharacterized protein XP_059601843.1 1509744 R 5061 CDS An12g06200 4985971 1512425..1514146 III 1 NT_166527.1 Title: strong similarity to hypothetical protein SCF91.02c - Streptomyces coelicolor; uncharacterized protein 1514146 4985971 An12g06200 Aspergillus niger uncharacterized protein XP_001395684.1 1512425 D 5061 CDS An12g06210 84592603 complement(join(1514321..1514773,1514935..1515267,1515418..1515564)) III 1 NT_166527.1 Title: similarity to hypothetical protein encoded by An11g09010 - Aspergillus niger; uncharacterized protein 1515564 84592603 An12g06210 Aspergillus niger uncharacterized protein XP_059601844.1 1514321 R 5061 CDS An12g06230 84592604 join(1516336..1516437,1516609..1516693,1516748..1516878) III 1 NT_166527.1 hypothetical protein 1516878 84592604 An12g06230 Aspergillus niger hypothetical protein XP_059601845.1 1516336 D 5061 CDS An12g06240 4985975 complement(join(1516922..1517245,1517309..1517986)) III 1 NT_166527.1 Title: weak similarity to hypothetical protein AAL32543.1 - Arabidopsis thaliana; uncharacterized protein 1517986 4985975 An12g06240 Aspergillus niger uncharacterized protein XP_059601846.1 1516922 R 5061 CDS An12g06250 4985976 complement(join(1519427..1519879,1520206..1520280)) III 1 NT_166527.1 Function: the secreted protein of patent Y11086 may be useful for treating or reducing the risk of H. pylori infections.; Similarity: shows weak similarity to the protein patent database entry GENESEQPROT:Y11086.; Title: weak similarity to secreted protein from patent WO9824475-A1 - Helicobacter pylori; uncharacterized protein 1520280 4985976 An12g06250 Aspergillus niger uncharacterized protein XP_059601847.1 1519427 R 5061 CDS An12g06270 84592605 complement(join(1520903..1521232,1521314..1521430,1521516..1521591,1521693..1521768,1521845..1521908)) III 1 NT_166527.1 Title: weak similarity to hypothetical caspase-8 CASP8 - Rattus norvegicus; uncharacterized protein 1521908 84592605 An12g06270 Aspergillus niger uncharacterized protein XP_059601848.1 1520903 R 5061 CDS An12g06280 84592606 join(1522041..1522383,1522438..1522483,1522850..1522968,1523118..1523188,1523285..1523515) III 1 NT_166527.1 Similarity: the sequence of residues 79 to 123 is similar to the repeat sequence of autolysin from Enterococcus faecalis (PubMed 1679432; patent GENESEQPROT:R85290).; hypothetical protein 1523515 84592606 An12g06280 Aspergillus niger hypothetical protein XP_059601849.1 1522041 D 5061 CDS An12g06290 4985980 join(1523778..1524101,1524157..1524983,1525031..1525260,1525315..1525496,1525549..1525578,1525632..1525705,1525757..1525805) III 1 NT_166527.1 Catalytic activity: KlDLD in K. lactis catalyzes the stereospecific oxidation of D-lactate to pyruvate: (R)-lactate + 2 ferricytochrome c <=> pyruvate + 2 ferrocytochrome c.; Function: KlDLD of K. lactis transfers two electrons from D-lactate to cytochrome c via FAD.; Induction: KlDLD in K. lactis is induced by it's substrate lactate at the transcriptional level.; Pathway: KlDLD of K. lactis is the key enzyme of D-lactate utilization which is linked to the respiratory chain.; Repression: KlDLD in K. lactis is repressed by glucose at the transcriptional level.; Title: strong similarity to D-lactate dehydrogenase dld - Kluyveromyces lactis; localisation:mitochondrion; See PMID 9683671; See PMID 7969031; uncharacterized protein 1525805 4985980 An12g06290 Aspergillus niger uncharacterized protein XP_059601850.1 1523778 D 5061 CDS An12g06300 4985981 complement(1526309..1527358) III 1 NT_166527.1 Function: LovC of A. terreus encodes a putative enoyl reductase.; Similarity: contains a Zn-binding dehydrogenases similarity domain.; Similarity: the 5'-part of the ORF shows similarity to a 5'-EST of the A. niger cDNA clone 3213 (EMBLEST:BE758951).; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994; uncharacterized protein 1527358 4985981 An12g06300 Aspergillus niger uncharacterized protein XP_001395692.1 1526309 R 5061 CDS An12g06310 4985982 join(1528310..1528375,1528449..1528559,1528626..1528784) III 1 NT_166527.1 Title: weak similarity to hypothetical protein MGD8.2 - Arabidopsis thaliana; uncharacterized protein 1528784 4985982 An12g06310 Aspergillus niger uncharacterized protein XP_001395693.1 1528310 D 5061 CDS An12g06340 4985985 complement(join(1529540..1529596,1529895..1531695,1531743..1532564,1532660..1532956,1533011..1533120)) III 1 NT_166527.1 Function: the human erythrocyte ankyrin ANK1 attachs integral membrane proteins to cytoskeletal elements. It binds to the erythrocyte membrane protein band 4. 2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein.; Title: similarity to erythrocyte ankyrin ANK1 - Homo sapiens; cytoskeleton; See PMID 1689849; See PMID 8226993; See PMID 8640229; uncharacterized protein 1533120 4985985 An12g06340 Aspergillus niger uncharacterized protein XP_059601851.1 1529540 R 5061 CDS An12g06350 10098114 join(1534110..1535450,1535570..1535624,1535795..1535861,1535913..1537044) III 1 NT_166527.1 Title: weak similarity to glucan synthase FKS -Paracoccidioides brasiliensis; uncharacterized protein 1537044 10098114 An12g06350 Aspergillus niger uncharacterized protein XP_003188870.2 1534110 D 5061 CDS An12g06360 84592607 join(1538257..1538486,1538580..1538778,1539178..1539201,1539244..1539295,1539355..1539575,1539663..1539830,1540212..1540313) III 1 NT_166527.1 Similarity: the similarities of the ORF encoded protein to all matching proteins are based on repetitive structures.; Title: weak similarity to transamidase GPI8 -Plasmodium falciparum; uncharacterized protein 1540313 84592607 An12g06360 Aspergillus niger uncharacterized protein XP_059601852.1 1538257 D 5061 CDS An12g06370 84592608 join(1540503..1540566,1540665..1540682,1540725..1540804,1540921..1541181) III 1 NT_166527.1 hypothetical protein 1541181 84592608 An12g06370 Aspergillus niger hypothetical protein XP_059601853.1 1540503 D 5061 CDS An12g06380 4985989 1542393..1544075 III 1 NT_166527.1 Function: fibroin heavy chain Fib-H from Bombyx mori (domestic silkworm) forms the silk filament; a strong,inextensible, insoluble and chemically inert fibre.; Remark: Bombyx mori=domestic silkworm.; Remark: the structure of the ORF encoded protein is highly repetitive.; Title: similarity to fibroin heavy chain Fib-H -Bombyx mori; extracellular/secretion proteins; See PMID 10366732; uncharacterized protein 1544075 4985989 An12g06380 Aspergillus niger uncharacterized protein XP_001395698.1 1542393 D 5061 CDS An12g06400 4985991 complement(join(1544896..1544966,1545013..1545164,1545234..1545817)) III 1 NT_166527.1 Function: recombinant Nor-1 from A. parasiticus expressed in E. coli converted the 1' keto group of norsolorinic acid to the 1' hydroxyl group of averantin in crude E. coli cell extracts in the presence of NADPH. The results confirm that Nor-1 functions as a ketoreductase in vitro.; Pathway: the Nor-1 ketoreductase from A. parasiticus is involved in the aflatoxin biosynthesis.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Title: strong similarity to norsolorinic acid ketoreductase nor-1 - Aspergillus parasiticus; See PMID 10584035; See PMID 7993094; uncharacterized protein 1545817 4985991 An12g06400 Aspergillus niger uncharacterized protein XP_059601854.1 1544896 R 5061 CDS An12g06420 84592609 <1548102..1549361 III 1 NT_166527.1 Remark: N-terminally truncated ORF due to the end of contig.; Title: similarity to gag-like protein protein from transposon TART-B1 - Drosophila melanogaster [truncated ORF]; See PMID 7809068; uncharacterized protein 1549361 84592609 An12g06420 Aspergillus niger uncharacterized protein XP_059601855.1 1548102 D 5061 CDS An12g06430 4985993 1549394..1553260 III 1 NT_166527.1 Title: strong similarity to reverse transcriptase of the LINE-like retrotransposon Tad1-1 - Neurospora crassa; See PMID 7512193; uncharacterized protein 1553260 4985993 An12g06430 Aspergillus niger uncharacterized protein XP_001395701.3 1549394 D 5061 CDS An12g06440 4985994 complement(1553509..1554651) III 1 NT_166527.1 Function: Lovastatin is a fungal polyketide derived metabolite isolated from a strain of Aspergillus terreus,which inhibits the 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase an enzyme involved as key rate-controlling step early in the cholesterol biosynthetic pathway.; Title: strong similarity to transesterase involved in the lovastatin biosynthesis LovD - Aspergillus terreus; See PMID 10334994; uncharacterized protein 1554651 4985994 An12g06440 Aspergillus niger uncharacterized protein XP_001395702.3 1553509 R 5061 CDS An12g06460 84592610 join(1556911..1556955,1557126..1557431,1557466..1557684) III 1 NT_166527.1 Title: similarity to hypothetical protein CG10383 -Drosophila melanogaster; uncharacterized protein 1557684 84592610 An12g06460 Aspergillus niger uncharacterized protein XP_059601856.1 1556911 D 5061 CDS An12g06470 4985997 complement(1558163..1559503) III 1 NT_166527.1 Title: weak similarity to AP1 protein from patent US5811536-A - Arabidopsis thaliana; uncharacterized protein 1559503 4985997 An12g06470 Aspergillus niger uncharacterized protein XP_001395704.3 1558163 R 5061 CDS An12g06480 4985998 complement(join(1560014..1561064,1561162..1561274,1561328..1561861,1561968..1562605,1562655..1562841)) III 1 NT_166527.1 Function: the AmdA transcriptional activator from A. nidulans is involved in the induction of the A. nidulans structual gene amdS (acetamidase).; Title: similarity to zinc-finger transcription factor amdA - Aspergillus nidulans; nucleus; See PMID 7596297; See PMID 9126617; uncharacterized protein 1562841 4985998 An12g06480 Aspergillus niger uncharacterized protein XP_001395705.3 1560014 R 5061 CDS An12g06490 4985999 join(1563550..1563669,1563731..1564545,1564596..1565391) III 1 NT_166527.1 Cofactor: the cofactor from human FMO1 enzyme is FAD.; Function: the human hepatic monooxygenase FMO1 is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. FMO1 catalyzes the N-oxygenation of secondary and tertiary amines.; Title: similarity to N-oxide-forming dimethylaniline monooxygenase FMO1 - Homo sapiens; See PMID 8128486; See PMID 1712018; uncharacterized protein 1565391 4985999 An12g06490 Aspergillus niger uncharacterized protein XP_001395706.1 1563550 D 5061 CDS An12g06500 4986000 complement(join(1566222..1566307,1566362..1566482,1566537..1566694,1566769..1567008,1567067..1567668,1567736..1567830,1567886..1568089,1568147..1568200)) III 1 NT_166527.1 Function: the S. cerevisiae Tna1 transporter is involved in the uptake of nicotinic acid.; Remark: alternate name for S. cerevisiae Tna1: YGR260W.; Similarity: the ORF encoded protein shows also strong similarity to the allantoate transporter Dal5/YJR152W from S. cerevisiae, but the accessible literature does not describe any functional characterization of Dal5 (Pubmed 3275614).; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563; uncharacterized protein 1568200 4986000 An12g06500 Aspergillus niger uncharacterized protein XP_059601857.1 1566222 R 5061 CDS An12g06510 4986001 join(1568615..1568651,1568712..1568885,1568950..1569126,1569182..1569493,1569559..1569700,1569758..1569839) III 1 NT_166527.1 Function: the gibberellin 7-oxidase from Cucurbita maxima is a 2-oxoglutarate dependent dioxygenase involved in final steps of gibberellin (GA) plant hormones biosynthesis.; Pathway: Gibberellin (GA) plant hormones biosynthesis.; Similarity: the ORF shows similarity to several putative oxidoreductases.; Similarity: the gibberellin 7-oxidase from Cucurbita maxima (winter squash) belongs to the superfamily of the 1-aminocyclopropane-1-carboxylate oxidases.; Title: similarity to gibberellin 7-oxidase -Cucurbita maxima; See PMID 9177256; uncharacterized protein 1569839 4986001 An12g06510 Aspergillus niger uncharacterized protein XP_059601858.1 1568615 D 5061 CDS An12g06520 4986002 complement(join(1570626..1570718,1570782..1570916,1570996..1571048,1571124..1571151,1571339..1571749,1571838..1572038,1572095..1572157)) III 1 NT_166527.1 Catalytic activity: a carboxylic ester + H(2)O <=> an alcohol + a carboxylic anion.; Remark: the esterase described in patent JP11075860-A is identical to the arylesterase from Acetobacter pasteurianus EST1; Title: similarity to esterase from patent JP11075860-A - Acetobacter pasteurianus; uncharacterized protein 1572157 4986002 An12g06520 Aspergillus niger uncharacterized protein XP_059601859.1 1570626 R 5061 CDS An12g06530 4986003 join(1572442..1572698,1572760..1572941,1573013..1573467,1573525..1573595,1573653..1574103,1574207..1574317) III 1 NT_166527.1 Catalytic activity: (S)-lactate + 2 ferricytochrome C <=> pyruvate + 2 ferrocytochrome C.; Cofactor: FMN; Protoheme IX.; Complex: Homotetramer.; Localization: the flavocytochrome b2 L-lactate dehydrogenas CYB2 from Pichia anomala is located in the mitochondrial intermembrane space.; Remark: Pichia anomala=Hansenula anomala.; Title: strong similarity to flavocytochrome b2 L-lactate dehydrogenase CYB2 - Pichia anomala; localisation:mitochondrion; See PMID 2688640; See PMID 3319613; uncharacterized protein 1574317 4986003 An12g06530 Aspergillus niger uncharacterized protein XP_059601860.1 1572442 D 5061 CDS An12g06540 4986004 join(1574683..1574802,1574954..1575395,1575450..1575877,1575949..1576118,1576199..1576541) III 1 NT_166527.1 Title: similarity to hypothetical conserved protein PA2682 - Pseudomonas aeruginosa; uncharacterized protein 1576541 4986004 An12g06540 Aspergillus niger uncharacterized protein XP_001395711.3 1574683 D 5061 CDS An12g06550 4986005 join(1577252..1577492,1577558..1577757,1577809..1578218,1578336..1578786,1578818..1578875,1578996..1579477) III 1 NT_166527.1 Title: similarity to hypothetical protein encoded by An01g11860 - Aspergillus niger; uncharacterized protein 1579477 4986005 An12g06550 Aspergillus niger uncharacterized protein XP_059601861.1 1577252 D 5061 CDS An12g06560 4986006 join(1580124..1580496,1580557..1580784,1580838..1581943,1582073..1582108) III 1 NT_166527.1 Catalytic activity: Triacylglycerol + H2O = Diacylglycerol + a Carboxylate; Diacylglycerol + H2O = Monoacylglycerol + a Carboxylate.; Pathway: Glycerolipid metabolism.; Title: strong similarity to triacylglycerol lipase Lip4 - Candida rugosa; See PMID 8440480; See PMID 10787175; uncharacterized protein 1582108 4986006 An12g06560 Aspergillus niger uncharacterized protein XP_059601862.1 1580124 D 5061 CDS An12g06580 4986008 1583331..1585541 III 1 NT_166527.1 Remark: Inactivation of the A. oryzae gene results in the inability to grow on gamma-amino-butyric acid (GABA) as a carbon and/or nitrogen source indicating that GABA utilization is amdR-dependent in A. oryzae as it is in A. nidulans.; Remark: amdR genes are highly conserved and functionally interchangeable between species.; Title: similarity to transcription regulator amdR -Aspergillus oryzae; See PMID 1452021; See PMID 2188110; uncharacterized protein 1585541 4986008 An12g06580 Aspergillus niger uncharacterized protein XP_001395714.1 1583331 D 5061 CDS An12g06590 4986009 1586359..1587393 III 1 NT_166527.1 Title: similarity to essential gene #7448 from patent WO200277183-A2 - Burkholderia fungorum; uncharacterized protein 1587393 4986009 An12g06590 Aspergillus niger uncharacterized protein XP_001395715.1 1586359 D 5061 CDS An12g06600 84592611 1588207..1588554 III 1 NT_166527.1 hypothetical protein 1588554 84592611 An12g06600 Aspergillus niger hypothetical protein XP_059601863.1 1588207 D 5061 CDS An12g06610 4986011 join(1589467..1589880,1589930..1590407,1590460..1591102,1591147..1591618) III 1 NT_166527.1 Title: weak similarity to mitogen-activated protein kinase MKC1 - Candida albicans; See PMID 7891715; uncharacterized protein 1591618 4986011 An12g06610 Aspergillus niger uncharacterized protein XP_001395717.3 1589467 D 5061 CDS An12g06620 84592612 join(1591879..1591927,1591969..1592008,1592066..1592085,1592203..1592297,1592328..1592588) III 1 NT_166527.1 hypothetical protein 1592588 84592612 An12g06620 Aspergillus niger hypothetical protein XP_059601864.1 1591879 D 5061 CDS An12g06630 84592613 complement(join(1593060..1593131,1593184..1593428,1593495..1593633)) III 1 NT_166527.1 Title: weak similarity to hypothetical protein F17K2.5 - Arabidopsis thaliana; uncharacterized protein 1593633 84592613 An12g06630 Aspergillus niger uncharacterized protein XP_059601865.1 1593060 R 5061 CDS An12g06640 84592614 join(1594538..1594561,1594770..1594873,1594917..1594965,1595138..1595173,1595440..1595521,1595608..1595816,1595873..1596277) III 1 NT_166527.1 Remark: Cdc48p of S. cerevisiae is more than twice the length of this protein.; Remark: the Yeast cell cycle protein CDC48p is a member of a protein family involved in secretion,peroxisome formation, and gene expression.; Title: weak similarity to valosin-containing protein like AAA-ATPase Cdc48 - Saccharomyces cerevisiae; See PMID 9695811; See PMID 1860879; uncharacterized protein 1596277 84592614 An12g06640 Aspergillus niger uncharacterized protein XP_059601866.1 1594538 D 5061 CDS An12g06650 84592615 complement(join(1596716..1598265,1598316..1598871)) III 1 NT_166527.1 Remark: similarity to dnaJ proteins belongs only to the dnaJ motif.; Title: weak similarity to hypothetical surface-located membrane protein 1 lmp1 - Borrelia burgdorferi; uncharacterized protein 1598871 84592615 An12g06650 Aspergillus niger uncharacterized protein XP_059601867.1 1596716 R 5061 CDS An12g06660 84592616 complement(join(1600605..1600662,1600794..1600841,1601119..1602531,1602764..1602772,1602901..1603027,1603195..1603282,1603645..1603764,1603810..1603983)) III 1 NT_166527.1 Title: strong similarity to hypothetical protein encoded by An11g03400 - Aspergillus niger; uncharacterized protein 1603983 84592616 An12g06660 Aspergillus niger uncharacterized protein XP_059601868.1 1600605 R 5061 CDS An12g06670 4986017 complement(join(1604506..1606755,1606807..1606878,1606929..1606967)) III 1 NT_166527.1 Title: similarity to hypothetical protein encoded by An08g12240 - Aspergillus niger; uncharacterized protein 1606967 4986017 An12g06670 Aspergillus niger uncharacterized protein XP_001395723.1 1604506 R 5061 CDS An12g06680 84592617 join(1607456..1607809,1607869..1607964) III 1 NT_166527.1 Title: similarity to hypothetical protein slr0852 -Synechocystis sp.; uncharacterized protein 1607964 84592617 An12g06680 Aspergillus niger uncharacterized protein XP_059601869.1 1607456 D 5061 CDS An12g06690 84592618 complement(join(1608135..1609002,1609162..1609606,1609658..1610197,1610244..1611246)) III 1 NT_166527.1 Catalytic activity: Phosphatidylcholine + H2O = 1-Acylglycerophosphocholine + a Carboxylate.; Remark: the homology is only at the C-terminal part.; Remark: the normal cofactor of this enzyme class is calcium.; Remark: the phospholipase A(2) (PLA(2)) superfamily consists of a broad range of enzymes defined by their ability to catalyze the hydrolysis of the middle (sn-2) ester bond of substrate phospholipids.; Title: similarity to calcium-independent phospholipase A2 - Homo sapiens; See PMID 10833412; See PMID 11080672; uncharacterized protein 1611246 84592618 An12g06690 Aspergillus niger uncharacterized protein XP_059601870.1 1608135 R 5061 CDS An12g06700 84592619 complement(join(1611509..1611898,1611949..1611996)) III 1 NT_166527.1 hypothetical protein 1611996 84592619 An12g06700 Aspergillus niger hypothetical protein XP_059601871.1 1611509 R 5061 CDS An12g06710 84592620 1612196..1612834 III 1 NT_166527.1 Remark: match found in blastXpatent analysis.; Title: weak similarity to ApoE4Lx2 protease from patent WO9413798-A - Homo sapiens; uncharacterized protein 1612834 84592620 An12g06710 Aspergillus niger uncharacterized protein XP_059601872.1 1612196 D 5061 CDS An12g06720 84592621 complement(join(1613169..1613264,1613312..1613481,1613534..1614069,1614582..1614632,1614778..1614862,1614980..1614995,1615051..1615170,1615266..1615286,1615453..1615545,1615902..>1616039)) III 1 NT_166527.1 Remark: N-terminal truncated orf due to end of contig.; Remark: only weakly conserved PFAM motif (PF00069 Eukaryotic protein kinase domain), but this ORF can probably be considered as having this domain; compare to the PFAM results,; Remark: shows weak similarity to several serine/threonine protein kinases.; Title: weak similarity to translation initiation factor eIF-2 alpha kinase GCN2 - Drosophila melanogaster [truncated ORF]; uncharacterized protein 1616039 84592621 An12g06720 Aspergillus niger uncharacterized protein XP_059601873.1 1613169 R 5061 CDS An12g06730 84592622 join(1618254..1618692,1618745..1618818,1618870..1619072,1619294..1620104) III 1 NT_166527.1 Title: weak similarity to metalloreductase freA -Aspergillus nidulans; uncharacterized protein 1620104 84592622 An12g06730 Aspergillus niger uncharacterized protein XP_059601874.1 1618254 D 5061 CDS An12g06740 84592623 1620482..1621267 III 1 NT_166527.1 Title: similarity to hypothetical protein encoded by An12g06730 - Aspergillus niger; uncharacterized protein 1621267 84592623 An12g06740 Aspergillus niger uncharacterized protein XP_059601875.1 1620482 D 5061 CDS An12g06750 84592624 complement(join(1621654..1621750,1621797..1622006,1622097..1622254)) III 1 NT_166527.1 hypothetical protein 1622254 84592624 An12g06750 Aspergillus niger hypothetical protein XP_059601876.1 1621654 R 5061 CDS An12g06760 84592625 complement(join(1622697..1622756,1622842..1623215,1623292..1623306,1623650..1623742,1623827..1623896)) III 1 NT_166527.1 Remark: the protein shows weak similarity to the mlr9023 transposase sequences of Mesorhizobium loti within the aminoacid sequence 89-148.; hypothetical protein 1623896 84592625 An12g06760 Aspergillus niger hypothetical protein XP_059601877.1 1622697 R 5061 CDS An12g06770 84592626 join(1624047..1625317,1625417..1625828) III 1 NT_166527.1 Remark: co-expression of antagonistic alleles of the unlinked loci het-e and het-c triggers a cell death reaction that prevents the formation of viable heterokaryons between strains that contain incompatible combinations of het-c and het-e alleles.; Remark: the A. niger gene is only one half of the lenght of the P. anserina protein.; Remark: the het-e-1 gene of the fungus Podospora anserina is responsible for vegetative incompatibility through specific interactions with different alleles of the unlinked gene, het-c.; Title: similarity to beta transducin-like protein het-e1 - Podospora anserina; See PMID 7557402; See PMID 9435787; uncharacterized protein 1625828 84592626 An12g06770 Aspergillus niger uncharacterized protein XP_059601878.1 1624047 D 5061 CDS An12g06780 84592627 complement(join(1625943..1626107,1626354..1626372,1626457..1626877,1626922..1626994)) III 1 NT_166527.1 Title: similarity to hypothetical protein encoded by An04g07590 - Aspergillus niger; uncharacterized protein 1626994 84592627 An12g06780 Aspergillus niger uncharacterized protein XP_059601879.1 1625943 R 5061 CDS An12g06790 84592628 complement(join(1629024..1629208,1629254..1629526,1629588..1630537,1630585..1630610)) III 1 NT_166527.1 hypothetical protein 1630610 84592628 An12g06790 Aspergillus niger hypothetical protein XP_059601880.1 1629024 R 5061 CDS An12g06800 84592629 join(1631215..1631364,1631436..1632491) III 1 NT_166527.1 Title: weak similarity to hypothetical protein encoded by An04g07590 - Aspergillus niger; uncharacterized protein 1632491 84592629 An12g06800 Aspergillus niger uncharacterized protein XP_059601881.1 1631215 D 5061 CDS An12g06810 4986031 join(1634239..1634439,1634487..1634699) III 1 NT_166527.1 hypothetical protein 1634699 4986031 An12g06810 Aspergillus niger hypothetical protein XP_001395737.1 1634239 D 5061 CDS An12g06820 4986032 complement(join(1634999..1636058,1636179..1636662,1637177..1637285,1637443..1637628)) III 1 NT_166527.1 hypothetical protein 1637628 4986032 An12g06820 Aspergillus niger hypothetical protein XP_059601882.1 1634999 R 5061 CDS An12g06830 4986033 1638493..1639428 III 1 NT_166527.1 Title: strong similarity to hypothetical protein encoded by An11g08100 - Aspergillus niger; uncharacterized protein 1639428 4986033 An12g06830 Aspergillus niger uncharacterized protein XP_001395739.1 1638493 D 5061 CDS An12g06840 84592630 complement(1640206..1640772) III 1 NT_166527.1 Title: similarity to hypothetical protein encoded by An02g09280 - Aspergillus niger; uncharacterized protein 1640772 84592630 An12g06840 Aspergillus niger uncharacterized protein XP_059601883.1 1640206 R 5061 CDS An12g06850 84592631 join(1641646..1641819,1641876..1642262) III 1 NT_166527.1 Title: similarity to hypothetical protein encoded by An12g06870 - Aspergillus niger; uncharacterized protein 1642262 84592631 An12g06850 Aspergillus niger uncharacterized protein XP_059601884.1 1641646 D 5061 CDS An12g06860 4986036 complement(join(1644454..1645219,1645266..1645483)) III 1 NT_166527.1 Title: strong similarity to hypothetical protein 68B2.10 - Neurospora crassa; uncharacterized protein 1645483 4986036 An12g06860 Aspergillus niger uncharacterized protein XP_001395742.3 1644454 R 5061 CDS An12g06870 84592632 complement(join(1646384..1646569,1646627..1646815)) III 1 NT_166527.1 Title: similarity to hypothetical protein encoded by An12g06850 - Aspergillus niger; uncharacterized protein 1646815 84592632 An12g06870 Aspergillus niger uncharacterized protein XP_059601885.1 1646384 R 5061 CDS An12g06880 84592633 complement(join(1648131..1650279,1650311..1650356,1650409..1650721)) III 1 NT_166527.1 hypothetical protein 1650721 84592633 An12g06880 Aspergillus niger hypothetical protein XP_059601886.1 1648131 R 5061 CDS An12g06890 4986039 complement(join(1652576..1654101,1654151..1654166)) III 1 NT_166527.1 Remark: the schistosome homologues of heat-shock protein Hsp70 elicit a dominant antibody response in humans infected with S. mansoni.; Title: strong similarity to dnaK-type molecular chaperone hsp70 - Schistosoma mansoni; See PMID 1484560; uncharacterized protein 1654166 4986039 An12g06890 Aspergillus niger uncharacterized protein XP_059601887.1 1652576 R 5061 CDS An12g06900 84592634 <1654959..1656113 III 1 NT_166527.1 Remark: ORF 5' truncated due to end of contig.; Title: weak similarity to DNA gyrase B subunit gyrB - Flexibacter japonensis [truncated ORF]; uncharacterized protein 1656113 84592634 An12g06900 Aspergillus niger uncharacterized protein XP_059604517.1 1654959 D 5061 CDS An12g06910 84592635 join(1658450..1658613,1658787..1658874) III 1 NT_166527.1 Similarity: similarity from predicted A. niger protein is to the N-terminus of C. thermosaccharolyticum xylose isomerase, which is 350 aa longer.; Title: weak similarity to xylose isomerase -Clostridium thermosaccharolyticum; uncharacterized protein 1658874 84592635 An12g06910 Aspergillus niger uncharacterized protein XP_059604518.1 1658450 D 5061 CDS An12g06920 84592636 join(1660015..1660458,1660511..1660996,1661044..1661361) III 1 NT_166527.1 Title: weak similarity to NAD-dependent DNA ligase -Thermus sp.; uncharacterized protein 1661361 84592636 An12g06920 Aspergillus niger uncharacterized protein XP_059604519.1 1660015 D 5061 CDS An12g06930 4986043 complement(join(1662331..1662618,1662698..1662938,1663004..1663150,1663216..1663378,1663437..1663665,1663734..1663842,1663912..1664027,1664114..1664152,1664208..1664372)) III 1 NT_166527.1 Catalytic activity: alpha-amylases catalyse the endohydrolysis of 1,4-alpha-glucosidic linkages in oligosaccharides and polysaccharides.; Gene-ID: amyA;amyB; Remark: nearly identical matches (even on DNA level) were found to other ORFs.; Remark: the A. niger transposon Ant1 is known to contain amyA 3'UTR sequences, therefore the genomic localization of the predicted A. niger protein could be due to a transposon induced rearrangment.; Remark: the adjacent genomic region contains several remnants of transposable elements and likely is a hotspot for transoposn insertion.; Similarity: the nucleotide sequences of amyA and amyB from A. niger are identical throughout all but the last few nucleotides of their respective coding regions.; See PMID 2340591; extracellular alpha-amylase amyA/amyB-Aspergillus niger 1664372 amyA 4986043 amyA Aspergillus niger extracellular alpha-amylase amyA/amyB-Aspergillus niger XP_001395749.3 1662331 R 5061 CDS An12g06940 4986044 join(1665327..1665380,1665462..1666949) III 1 NT_166527.1 Remark: the adjacent genomic region contains several remnants of transposable elements and likely is a hotspot for transoposon insertion.; Remark: the central region of the A. niger transposon Ant1 contains the 3' UTR of the amyA from A. niger.; Remark: the predicted A. niger protein shows strong similarity on DNA level to the 3' UTR of amyA from A. niger.; Title: strong similarity to hypothetical protein encoded by An05g02110 - Aspergillus niger; See PMID 8552048; uncharacterized protein 1666949 4986044 An12g06940 Aspergillus niger uncharacterized protein XP_059604520.1 1665327 D 5061 CDS An12g06960 4986045 join(1667243..1667651,1667711..1668030,1668082..1668546) III 1 NT_166527.1 Remark: the adjacent genomic region contains several remnants of transposable elements and likely is a hotspot for transoposn insertion.; Similarity: similarity is from C-terminal 100 aa of the predicted A. niger protein to N-terminus of PDC E1 alpha from A. thaliana.; Title: weak similarity to E1 alpha subunit of pyruvate dehydrogenase complex PDC - Arabidopsis thaliana; See PMID 7590338; uncharacterized protein 1668546 4986045 An12g06960 Aspergillus niger uncharacterized protein XP_059604521.1 1667243 D 5061 CDS An12g06970 4986046 complement(join(1668937..1669494,1669576..1669734)) III 1 NT_166527.1 Complex: other domains of S. cerevisiae Djp1p interact with the substrates for the Hsp70 machinery.; Complex: the DnaJ-domain of S. cerevisiae Djp1p specifies the interaction with a particular Hsp70.; Function: S. cerevisiae Djp1p in conjunction with hsp70 proteins is specifically required for peroxisomal protein import.; Remark: YIR004w is the systematic name for S. cerevisiae Djp1p.; Remark: the adjacent genomic region contains several remnants of transposable elements and likely is a hotspot for transoposn insertion.; Similarity: similarity of predicted A. niger protein is confined to N-terminal half of S. cerevisiae Djp1p which is 200 aa longer.; Title: similarity to DnaJ-like protein Djp1 -Saccharomyces cerevisiae; cytoplasm; See PMID 9679141; uncharacterized protein 1669734 4986046 An12g06970 Aspergillus niger uncharacterized protein XP_001395752.1 1668937 R 5061 CDS An12g06980 4986047 join(1670953..1671400,1671460..1671506) III 1 NT_166527.1 Remark: the adjacent genomic region contains several remnants of transposable elements and likely is a hotspot for transoposn insertion.; Title: strong similarity to EST SEQ ID NO:6341 from patent WO200056762-A2 - Aspergillus oryzae; uncharacterized protein 1671506 4986047 An12g06980 Aspergillus niger uncharacterized protein XP_001395753.1 1670953 D 5061 CDS An12g06990 4986048 join(1672560..1672599,1672647..1672828) III 1 NT_166527.1 Remark: the adjacent genomic region contains several transposon related sequences, indicating a hotspot for transposon insertion.; Similarity: the predicted A. niger protein is only a 100 aa remnant of the 1230 aa reverse transcriptase homologe from C. intestinalis.; Title: similarity to hypothetical reverse transcriptase homolog - Ciona intestinalis; uncharacterized protein 1672828 4986048 An12g06990 Aspergillus niger uncharacterized protein XP_001395754.3 1672560 D 5061 CDS An12g07000 4986049 complement(1673003..1673983) III 1 NT_166527.1 Function: ORF1 of A. niger Ant1 encodes the Ant1 transposase.; Remark: in the adjacent genomic region only remnants of the complete Ant1 transposon are found on both DNA strands, spaced from base 55168 to 63290.; Remark: the adjacent genomic region contains several transposon related sequences, indicating a hotspot for transposon insertion.; Title: strong similarity to protein encoded by ORF1 of transposon Ant1 - Aspergillus niger; See PMID 8552048; uncharacterized protein 1673983 4986049 An12g07000 Aspergillus niger uncharacterized protein XP_001395755.1 1673003 R 5061 CDS An12g07020 4986051 complement(1675364..1676629) III 1 NT_166527.1 Complex: S. cerevisiae Hoc1 together with Anp1, Mnn9, Mnn10, and Mnn11 forms the Golgi mannosyltransferase A-complex.; Function: S. cerevisiae HOC1 has been suggested to encode a Golgi-localized putative mannosyltransferase required for the proper construction of the cell wall.; Function: S. cerevisiae Hoc1 is a component of the Golgi mannosyltransferase A-complex, which also shows protein O-glycosylation activity.; Golgi; Title: strong similarity to alpha-1,6-mannosyltransferase Hoc1 - Saccharomyces cerevisiae; See PMID 9055074; See PMID 10635561; uncharacterized protein 1676629 4986051 An12g07020 Aspergillus niger uncharacterized protein XP_001395756.3 1675364 R 5061 CDS An12g07030 4986052 join(1677173..1677179,1677374..1677515,1677592..1678168) III 1 NT_166527.1 Function: S. cerevisiae Wsc proteins are putative transmembrane stress receptors and upstream activators of the RHO1-regulated PKC1-MAP kinase cascade.; Function: S. cerevisiae Wsc proteins are required for maintenance of cell wall integrity and the stress response.; Remark: YOL105c is the systematic name for WSC3.; Similarity: the predicted A. niger protein contains predicted WSC- and transmembrane domains.; Title: weak similarity to stress response mediator Wsc3 - Saccharomyces cerevisiae; See PMID 10394905; See PMID 10430578; uncharacterized protein 1678168 4986052 An12g07030 Aspergillus niger uncharacterized protein XP_059604522.1 1677173 D 5061 CDS An12g07040 84592637 join(1679043..1679085,1679246..1679277,1679610..1679789) III 1 NT_166527.1 Remark: ORF questionable due to short length and nearly entirely consisting of lysine.; Similarity: ORF shows unspecific similarity to lysine rich proteins.; Title: questionable ORF; uncharacterized protein 1679789 84592637 An12g07040 Aspergillus niger uncharacterized protein XP_059604523.1 1679043 D 5061 CDS An12g07050 84592638 complement(join(1680318..1680471,1680545..1680986,1681048..1681131,1681187..1681205,1681263..1681304)) III 1 NT_166527.1 Remark: 5' of this predicted A. niger protein is an ORF which also shows similarity to the N-terminal region of drf1, possibly indicating a gene duplication.; Similarity: the similarity of the predicted A. niger protein is to the N-termnal region of S. pombe dfr1, while the conserved dihydrofolate reductase domain is at the C-terminus of dfr1.; Title: weak similarity to dihydrofolate reductase dfr1p - Schizosaccharomyces pombe; See PMID 8088538; uncharacterized protein 1681304 84592638 An12g07050 Aspergillus niger uncharacterized protein XP_059604524.1 1680318 R 5061 CDS An12g07060 4986055 complement(join(1681555..1681712,1681784..1682269,1682375..1682393,1682443..1682484)) III 1 NT_166527.1 Remark: coincidentally the ORF 3' of this predicted A. niger protein itself shows similarity to dfr1 of S. pombe indicating a possible gene duplication.; Remark: the hypothetical protein YMR222c of S. cerevisiae shows similarity to dihydrofolate reductase dfr1 of S. pombe.; Title: similarity to hypothetical protein YMR222c -Saccharomyces cerevisiae; uncharacterized protein 1682484 4986055 An12g07060 Aspergillus niger uncharacterized protein XP_059604525.1 1681555 R 5061 CDS An12g07070 4986056 join(1683170..1683882,1683957..1684243,1684304..1689138,1689186..1689966,1690238..1690335) III 1 NT_166527.1 Title: strong similarity to polyketide synthase PKS1 - Cochliobolus heterostrophus; See PMID 8953776; uncharacterized protein 1690335 4986056 An12g07070 Aspergillus niger uncharacterized protein XP_059604526.1 1683170 D 5061 CDS An12g07090 4986058 complement(join(1690608..1691386,1691437..1691560,1691611..1692036)) III 1 NT_166527.1 Function: 6-HDNO of A. oxidans specifically oxidizes 6-hydroxy-D-nicotine to 6-hydroxy-N-methylmyosmine.; Remark: at position 37530 a possible sequencing error was corrected.; Similarity: the predicted A. niger protein shows similarity to several oxygen oxidoreductases that covalently bind FAD.; Similarity: the similarity between the predicted A. niger protein and 6-HDNO from A. oxidans is confined to the FAD binding domain.; Title: similarity to 6-hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans [putative sequencing error]; putative sequencing error; See PMID 2115879; See PMID 3622516; uncharacterized protein 1692036 4986058 An12g07090 Aspergillus niger uncharacterized protein XP_059604527.1 1690608 R 5061 CDS An12g07100 4986059 complement(join(1693583..1694041,1694116..1694457,1694506..1694718)) III 1 NT_166527.1 Function: cucumopine synthase produces cucumopine, a guanido amino acid of unknown function.; Remark: no literature was available also a Genbank entry from 08-SEP-2000 contains a 'in press' statement.; Title: strong similarity to cucumopine synthase cus - Agrobacterium rhizogenes; uncharacterized protein 1694718 4986059 An12g07100 Aspergillus niger uncharacterized protein XP_001395763.1 1693583 R 5061 CDS An12g07110 4986060 join(1696524..1696537,1696721..1696810,1696941..1696980,1697400..1698629) III 1 NT_166527.1 Catalytic activity: the anthranilate synthase complex catalyses the reaction, Chorismate + L-glutamine <=> anthranilate + pyruvate + L-glutamate.; Function: Y. pestis YbtS is part of the anthranilate synthase complex, which can be involved in the biosynthesis of tryptophan.; Function: Y. pestis YbtS might be necessary for converting chorismate to salicylate.; Title: strong similarity to anthranilate synthase component I ybtS - Yersinia pestis; See PMID 9818149; uncharacterized protein 1698629 4986060 An12g07110 Aspergillus niger uncharacterized protein XP_001395764.3 1696524 D 5061 CDS An12g07120 4986061 join(1703429..1703560,1703612..1703653,1703711..1703830,1703898..1704069,1704151..1704234,1704304..1704400,1704462..1704579,1704648..1704933,1705021..1705258,1705319..1705505) III 1 NT_166527.1 Function: P450 enzymes usually act as terminal oxidases in multicomponent electron transfer chains in a multitude of biochemical pathways. .; Similarity: the C-terminus of the predicted A. niger protein contains a conserved P450 monooxygenase domain.; Title: similarity to cytochrome P450 monooxygenase P450II - Gibberella fujikuroi; See PMID 9917370; uncharacterized protein 1705505 4986061 An12g07120 Aspergillus niger uncharacterized protein XP_059604528.1 1703429 D 5061 CDS An12g07130 4986062 complement(join(1705877..1706821,1706876..1706944)) III 1 NT_166527.1 Title: strong similarity to hypothetical protein cipA - Aspergillus nidulans; uncharacterized protein 1706944 4986062 An12g07130 Aspergillus niger uncharacterized protein XP_001395766.1 1705877 R 5061 CDS An12g07140 4986063 complement(1707494..1709203) III 1 NT_166527.1 Function: Rdr1 from S. cerevisiae acts as a transcriptional repressor of multiple genes.; Similarity: the N-terminal region of the predicted A. niger protein contains a GAL4-type Z(2)-Cys(6) DNA-binding domain.; Title: strong similarity to zinc-finger transcription factor Rdr1 - Saccharomyces cerevisiae; nucleus; See PMID 11882665; uncharacterized protein 1709203 4986063 An12g07140 Aspergillus niger uncharacterized protein XP_001395767.1 1707494 R 5061 CDS An12g07150 4986064 join(1711504..1711578,1711646..1712062) III 1 NT_166527.1 Function: R. etlic NifA is a transcriptional regulator of nitrogen fixation.; Similarity: the predicted A. niger protein shows similarity to a domain of the transcriptional regulator NifA from R. etli required for RNA pol-II sigma-54 factor interaction and ATP-binding.; Title: weak similarity to NIF-specific regulatory protein NIFA - Rhizobium etli; See PMID 9560416; uncharacterized protein 1712062 4986064 An12g07150 Aspergillus niger uncharacterized protein XP_001395768.1 1711504 D 5061 CDS An12g07160 10098117 join(1712853..1712870,1712930..1713292,1713460..1713495,1713550..1714890) III 1 NT_166527.1 Similarity: predicted A. niger protein contains a C-terminal putative ATPase domain and shows similarity to several ATPase domain containing proteins.; Similarity: similarity of predicted A. niger protein is between its C-terminus and the C-terminal ATPase domain of myosin heavey chain of G. gallus.; Title: weak similarity to myosin heavy chain -Gallus gallus; uncharacterized protein 1714890 10098117 An12g07160 Aspergillus niger uncharacterized protein XP_003188873.2 1712853 D 5061 CDS An12g07170 4986066 complement(join(1714982..1716184,1716246..1716523,1716579..1716840,1716900..1717169)) III 1 NT_166527.1 Function: S. cerevisiae DUR3 is a urea symporter mediating urea import.; Induction: High-level expression of S. cerevisiae DUR3 is inducer dependent, requiring functional DAL81 and DAL82 genes.; Regulation: Expression of S. cerevisiae DUR3 is regulated in a manner similar to that of other genes in the allantoin pathway.; Repression: DUR3 expression is highly sensitive to nitrogen catabolite repression and also has a partial requirement for the GLN3 product.; Repression: Maintenance of S. cerevisiae DUR3 mRNA at uninduced, nonrepressed basal levels requires the negatively acting DAL80 gene product.; Similarity: S. cerevisiae DUR3 belongs to the major facilitator family.; Title: strong similarity to urea transport protein Dur3 - Saccharomyces cerevisiae; plasma membrane; See PMID 8335627; uncharacterized protein 1717169 4986066 An12g07170 Aspergillus niger uncharacterized protein XP_001395770.1 1714982 R 5061 CDS An12g07180 4986067 complement(join(1719228..1719566,1719626..1720051)) III 1 NT_166527.1 Function: SalE of Acinetobacter sp. was shown to have esterase activity against short-chain alkyl esters of 4-nitrophenol but was also able to hydrolyze ethyl salicylate to ethanol and salicylic acid.; Title: similarity to alkyl salicylate esterase salE - Acinetobacter sp.; See PMID 10715011; uncharacterized protein 1720051 4986067 An12g07180 Aspergillus niger uncharacterized protein XP_001395771.1 1719228 R 5061 CDS An12g07190 4986068 complement(join(1720698..1721250,1721329..1721667,1721729..1721893,1721950..1722101,1722160..1722756,1722814..1722942)) III 1 NT_166527.1 Function: nirA of A. nidulans is a zinc finger transcription factor mediating nitrate induction of genes involved in nitrate assimilation (nitrate reductase,nitrite reductases and a nitrate permease, niaD, niiA and crnA, respectively).; Remark: the nitrate assimilation genes are induced by nitrate and repressed by ammonium at the transcriptional level.; Remark: the predicted A. niger protein is C-terminal 200 aa shorter than nirA of A. nidulans.; Similarity: nirA of A. nidulans belongs to the family of Gal4 Zn(2)-Cys(6)-finger transcription factors.; Title: similarity to nitrate assimilation regulatory protein nirA - Aspergillus nidulans; nucleus; See PMID 1922075; uncharacterized protein 1722942 4986068 An12g07190 Aspergillus niger uncharacterized protein XP_059604529.1 1720698 R 5061 CDS An12g07200 84592639 1723919..1724545 III 1 NT_166527.1 Title: weak similarity to hypothetical seryl-tRNA synthase APE1976 - Aeropyrum pernix; uncharacterized protein 1724545 84592639 An12g07200 Aspergillus niger uncharacterized protein XP_059604530.1 1723919 D 5061 CDS An12g07210 84592640 join(1725481..1725887,1726018..1726150) III 1 NT_166527.1 Remark: the predicted A. niger protein shows similarity to the N-terminal region of S. cerevisiae YML002w, which is 550 aa longer.; Title: weak similarity to hypothetical membrane protein YML002w - Saccharomyces cerevisiae; uncharacterized protein 1726150 84592640 An12g07210 Aspergillus niger uncharacterized protein XP_059604531.1 1725481 D 5061 CDS An12g07220 4986071 1727870..1729201 III 1 NT_166527.1 Similarity: similarity is confined to N-terminal region.; Title: weak similarity to antibacterial glycoprotein achacin - Achatina fulica; See PMID 1396687; uncharacterized protein 1729201 4986071 An12g07220 Aspergillus niger uncharacterized protein XP_001395775.3 1727870 D 5061 CDS An12g07230 4986072 join(1730969..1731344,1731413..1743030) III 1 NT_166527.1 Function: the S. chrysomallus actinomycin synthetases ACMS I, II, and III catalyze the assembly of the acyl peptide lactone precursor of actinomycin by a nonribosomal mechanism.; Title: strong similarity to enniatin synthase esyn1 - Fusarium scirpi; See PMID 9573200; See PMID 9667890; uncharacterized protein 1743030 4986072 An12g07230 Aspergillus niger uncharacterized protein XP_001395776.1 1730969 D 5061 CDS An12g07240 4986073 join(1743719..1744443,1744719..1744752) III 1 NT_166527.1 Title: similarity to hypothetical protein AAM35689.1 - Xanthomonas axonopodis; uncharacterized protein 1744752 4986073 An12g07240 Aspergillus niger uncharacterized protein XP_001395777.3 1743719 D 5061 CDS An12g07250 4986074 complement(join(1745020..1745085,1745195..1745316,1745348..1745368,1745462..1745566,1745648..1746029,1746090..1746319,1746377..1747218,1747270..1747307,1747362..1747479,1747530..1748722)) III 1 NT_166527.1 Similarity: protein is more than twice as long as protein from T. maritima and shows similarity twice to full length of T. maritima protein, stronger at N-terminus and weaker at C-terminus.; Title: similarity to hypothetical conserved protein - Thermotoga maritima; uncharacterized protein 1748722 4986074 An12g07250 Aspergillus niger uncharacterized protein XP_001395778.3 1745020 R 5061 CDS An12g07260 4986075 join(1749361..1749786,1749823..1750149) III 1 NT_166527.1 Title: strong similarity to hypothetical protein SC4B10.22 - Streptomyces coelicolor; uncharacterized protein 1750149 4986075 An12g07260 Aspergillus niger uncharacterized protein XP_059604532.1 1749361 D 5061 CDS An12g07270 84592641 1750534..1751580 III 1 NT_166527.1 Title: similarity to hypothetical protein encoded by An14g02930 - Aspergillus niger; uncharacterized protein 1751580 84592641 An12g07270 Aspergillus niger uncharacterized protein XP_059604533.1 1750534 D 5061 CDS An12g07280 4986077 complement(join(1751828..1753408,1753466..1753693)) III 1 NT_166527.1 Catalytic activity: an aromatic primary alcohol + O(2) <=> an aromatic aldehyde + H(2)O(2).; Function: a double bond conjugated with a primary alcohol is necessary for substrate recognition by P. eryngii aao, and that activity is increased by the presence of additional conjugated double bonds and electron donor groups.; Function: aao from P. eryngii is an extracellular enzyme and constitutes a source for H2O2 required in lignin biodegradation.; Function: aao from P. eryngii presents wide specificity, showing activity on benzyl, cinnamyl, naphthyl and aliphatic unsaturated alcohols.; Title: strong similarity to aryl-alcohol oxidase precursor aao - Pleurotus eryngii; extracellular/secretion proteins; See PMID 10377251; See PMID 1425667; uncharacterized protein 1753693 4986077 An12g07280 Aspergillus niger uncharacterized protein XP_001395781.1 1751828 R 5061 CDS An12g07300 4986079 complement(1759368..1759913) III 1 NT_166527.1 hypothetical protein 1759913 4986079 An12g07300 Aspergillus niger hypothetical protein XP_001395782.1 1759368 R 5061 CDS An12g07320 4986081 join(1761329..1761682,1761760..1761943,1762021..1762280,1762341..1762673) III 1 NT_166527.1 Function: AWI 31 from A. thaliana is specifically induced by wounding.; Title: strong similarity to induced upon wounding stress protein AWI 31 - Arabidopsis thaliana; See PMID 9085278; uncharacterized protein 1762673 4986081 An12g07320 Aspergillus niger uncharacterized protein XP_059604534.1 1761329 D 5061 CDS An12g07330 4986082 complement(join(1762823..1763797,1763852..1764439,1764500..1765274,1765382..1765572)) III 1 NT_166527.1 Function: deletion and fusion constructs and in vitro mutagenesis indicated that the Zn(II)2Cys6 cluster and the C-terminal end of A. nidulans FacB are required for function.; Function: deletion of the gene confirmed that it is required for growth on acetate as a sole carbon source.; Function: facB of A. nidulans encodes a N-terminal GAL4-like Zn(II)2Cys6 transcriptional activator.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; uncharacterized protein 1765572 4986082 An12g07330 Aspergillus niger uncharacterized protein XP_001395784.3 1762823 R 5061 CDS An12g07340 84592642 join(1766189..1766656,1766695..1766734,1766792..1767002,1767058..1767202) III 1 NT_166527.1 Title: similarity to hypothetical protein EAA61153.1 - Aspergillus nidulans; uncharacterized protein 1767202 84592642 An12g07340 Aspergillus niger uncharacterized protein XP_059604535.1 1766189 D 5061 CDS An12g07350 84592643 complement(join(1770095..1770327,1770586..1770619,1770862..1770872,1770942..1771146,1771406..1771648)) III 1 NT_166527.1 Remark: shows unspecific similarity to serine rich proteins.; hypothetical protein 1771648 84592643 An12g07350 Aspergillus niger hypothetical protein XP_059604536.1 1770095 R 5061 CDS An12g07360 4986085 complement(1773977..1774210) III 1 NT_166527.1 Function: S. cerevisiae Hub1 is an ubiquitin like protein that becomes covalently attached to target proteins and likely regulates activity of target proteins.; Remark: information regarding S. cerevisiae Hub1 has not been published and is available at http://www. biochem. mpg. de/jentsch/Jentsch. html.; Remark: the systematic name for S. cerevisiae HUB1 is YNR032c-a.; Title: strong similarity to ubiquitin like modifier Hub1 - Saccharomyces cerevisiae; uncharacterized protein 1774210 4986085 An12g07360 Aspergillus niger uncharacterized protein XP_001395787.3 1773977 R 5061 CDS An12g07370 4986086 complement(join(1775036..1775412,1775461..1775756,1775803..1775894,1775941..1776946,1777230..1777528)) III 1 NT_166527.1 Remark: part of the predicted A. niger protein is identical to an A. niger EST, an_3257.; Similarity: a DNA-binding motif within the predicted A. niger protein is only detected against the Structural Classification of Proteins database, not against other protein motif databases.; Similarity: the predicted A. niger protein shows similarity to several DNA-binding proteins.; Title: similarity to hypothetical protein CAE76230.1 - Neurospora crassa; uncharacterized protein 1777528 4986086 An12g07370 Aspergillus niger uncharacterized protein XP_059604537.1 1775036 R 5061 CDS An12g07380 4986087 complement(join(1778626..1778825,1778882..1779580,1779728..1779908,1779960..1780124,1780184..1780377,1780435..1780693)) III 1 NT_166527.1 Remark: moxY of A. parasiticus is expressed concurrently with genes involved in aflatoxin biosynthesis and it lies on one end of the cluster of this genes. Therefore moxY of A. parasiticus is presumably also involved in aflatoxin biosynthesis.; Similarity: the predicted A. niger protein shows simiilarity to several monooxygenases involved in polyketide or sterois metabolism.; Title: strong similarity to monooxygenase moxY -Aspergillus parasiticus; See PMID 10855719; uncharacterized protein 1780693 4986087 An12g07380 Aspergillus niger uncharacterized protein XP_059604538.1 1778626 R 5061 CDS An12g07390 4986088 join(1783294..1784398,1784455..1784477,1784534..1784993,1785066..1785466) III 1 NT_166527.1 Catalytic activity: phenol hydroxylases transform phenol + NADPH2 + O2 to catechol + NADP + H2O.; Complex: T. cutaneum phenol hydroxylase is a dimeric flavoenzyme.; Function: T. cutaneum phenol hydroxylase forms the first step in phenol metabolism by o-hydroxylysing phenol.; Title: strong similarity to phenol hydroxylase -Trichosporon cutaneum; See PMID 1429434; See PMID 7851397; uncharacterized protein 1785466 4986088 An12g07390 Aspergillus niger uncharacterized protein XP_001395790.1 1783294 D 5061 CDS An12g07400 4986089 join(1786549..1786944,1786990..1787379,1787426..1788433) III 1 NT_166527.1 Function: S. cerevisiae TPO1 mediates H+-gradient dependent vacuolar transport of polyamines, like spermine (TC 2. A. 1. 2).; Function: S. cerevisiae TPO1 shows hight structural similarity to E. coli PotE which mediates membrane potential dependent uptake of putrescine, while excretion involves an exchange reaction between putrescine and ornithine.; Remark: the systematic name for S. cerevisiae TOP1 is YLL028w.; Title: strong similarity to polyamine transport protein Tpo1 - Saccharomyces cerevisiae; vacuole; See PMID 9920864; See PMID 10585849; See PMID 11470516; uncharacterized protein 1788433 4986089 An12g07400 Aspergillus niger uncharacterized protein XP_001395791.1 1786549 D 5061 CDS An12g07420 4986091 complement(1789698..1790519) III 1 NT_166527.1 Title: weak similarity to hypothetical protein encoded by An01g10470 - Aspergillus niger; uncharacterized protein 1790519 4986091 An12g07420 Aspergillus niger uncharacterized protein XP_001395792.1 1789698 R 5061 CDS An12g07430 4986092 complement(join(1791186..1791613,1791667..1791832,1791891..1792033,1792082..1792234,1792287..1792524)) III 1 NT_166527.1 Similarity: the central region of the predicted A. niger protein contains a glyoxalase II hydrolase motif.; Title: similarity to homeostasis assocoiated protein sequence SEQ ID NO:380 from patent WO200100842-A2 -Corynebacterium glutamicum; uncharacterized protein 1792524 4986092 An12g07430 Aspergillus niger uncharacterized protein XP_001395793.1 1791186 R 5061 CDS An12g07450 4986094 complement(join(1795180..1795197,1795338..1795616,1795662..1796012,1796062..1796113,1796190..1796926,1796985..1797152)) III 1 NT_166527.1 Function: S. cerevisiae Rgt2p is a glucose sensor in the membrane which generates the intracellular signal inhibiting the transcriptional repressor Rgt1.; Function: inhibition of Rgt1 by S. cerevisiae Rgt2p induces expression of HXT glucose transporters.; Remark: the systematic name for S. cerevisiae RGT2 is YDL138w.; Title: strong similarity to glucose permease Rgt2 -Saccharomyces cerevisiae; plasma membrane; See PMID 9564039; See PMID 10477308; uncharacterized protein 1797152 4986094 An12g07450 Aspergillus niger uncharacterized protein XP_059604539.1 1795180 R 5061 CDS An12g07460 84592644 complement(join(1798917..1799282,1799833..1799904)) III 1 NT_166527.1 hypothetical protein 1799904 84592644 An12g07460 Aspergillus niger hypothetical protein XP_059604540.1 1798917 R 5061 CDS An12g07470 4986096 complement(join(1800267..1800511,1800654..1800795)) III 1 NT_166527.1 Function: N. ellipsosporum CV-N has anti-HIV activity.; Remark: blastp shows significant similarity (45% positives) between predicted A. niger protein and N. ellipsosporum CV-N but due to shortness of both peptides the calculated probability is low (p=0,018).; Title: weak similarity to cyanovirin-N CV-N - Nostoc ellipsosporum; See PMID 9299483; uncharacterized protein 1800795 4986096 An12g07470 Aspergillus niger uncharacterized protein XP_001395796.3 1800267 R 5061 CDS An12g07480 84592645 complement(join(1801232..1801244,1801321..1801427,1801510..1801551)) III 1 NT_166527.1 Title: questionable ORF; uncharacterized protein 1801551 84592645 An12g07480 Aspergillus niger uncharacterized protein XP_059604541.1 1801232 R 5061 CDS An12g07490 4986098 complement(join(1802179..1802384,1802433..1803032,1803095..1803164)) III 1 NT_166527.1 Function: rhlG encodes an NADPH-dependent beta-ketoacyl reductase which is specifically involved in the synthetic pathway for the fatty acid moiety of rhamnolipids.; Title: similarity to beta-ketoacyl reductase rhlG -Pseudomonas aeruginosa; See PMID 9721281; uncharacterized protein 1803164 4986098 An12g07490 Aspergillus niger uncharacterized protein XP_001395798.1 1802179 R 5061 CDS An12g07500 4986099 complement(join(1804231..1804278,1804329..1804403,1804457..1804558,1804611..1804799,1804851..1805011,1805063..1805121,1805178..1805544,1805609..1805915)) III 1 NT_166527.1 Catalytic activity: {(1,4)-alpha-D-galacturonide}(N) + H(2)O = {(1,4)-alpha-D- galacturonide}(N-1) + D-galacturonate.; Function: pgaX is an exopolygalacturonase [poly(1,4-alpha-D-galacturonide)galacturonohydrolase] that cleaves monomer units from the non-reducing end of pectate and other galacturonans.; Induction: expression of the pgaX gene is inducible with galacturonic acid.; Repression: expression of the pgaX gene is subject to catabolite repression.; Title: strong similarity to exopolygalacturonase pgaX - Aspergillus tubingensis; extracellular/secretion proteins; See PMID 10467119; See PMID 8856078; uncharacterized protein 1805915 4986099 An12g07500 Aspergillus niger uncharacterized protein XP_001395799.1 1804231 R 5061 CDS An12g07510 4986100 complement(join(1806832..1807015,1807072..1807208,1807313..1807328,1807427..1807620)) III 1 NT_166527.1 Title: similarity to secreted protein #70 from patent WO9925825-A2 - Homo sapiens; uncharacterized protein 1807620 4986100 An12g07510 Aspergillus niger uncharacterized protein XP_001395800.1 1806832 R 5061 CDS An12g07520 4986101 join(1808133..1808218,1808282..1808388,1808451..1808483,1808539..1808597) III 1 NT_166527.1 Remark: the 10. 5 kD subunit of the respiratory chain complex I is one of the smallest chains.; Title: strong similarity to 10.5 kD subunit of NADH:ubiquinone reductase CI-B8 - Bos taurus; localisation:mitochondrion; See PMID 1518044; uncharacterized protein 1808597 4986101 An12g07520 Aspergillus niger uncharacterized protein XP_001395801.1 1808133 D 5061 CDS An12g07530 4986102 complement(join(<1808730..1809193,1809249..1809409,1809477..1810085)) III 1 NT_166527.1 Remark: sequencing error at position 15524, 1 bp too much.; Title: strong similarity to hypothetical protein B2J23.80 - Neurospora crassa [putative frameshift]; putative frameshift; uncharacterized protein 1810085 4986102 An12g07530 Aspergillus niger uncharacterized protein XP_059604542.1 1808730 R 5061 CDS An12g07540 4986103 complement(join(1810781..1810914,1810971..1813163,1813216..1813579)) III 1 NT_166527.1 Complex: it appears that Chs4p is involved in chitin synthase 3 activity by combining with Chs3p to interact synergistically in chitin biosynthesis.; Function: CHS4 is involved in chitin biosynthesis.; Phenotype: CSH4 null mutants have a chitin content of 10% of that of the parental strain.; Title: similarity to chitin synthase regulatory factor CHS4 - Candida albicans; See PMID 10439400; uncharacterized protein 1813579 4986103 An12g07540 Aspergillus niger uncharacterized protein XP_001395803.1 1810781 R 5061 CDS An12g07550 4986104 join(1815547..1815679,1815716..1815782,1815936..1816028,1816319..1816435,1816497..1816681,1816763..1816890) III 1 NT_166527.1 Title: weak similarity to regulator protein Cbp4 -Saccharomyces cerevisiae; uncharacterized protein 1816890 4986104 An12g07550 Aspergillus niger uncharacterized protein XP_001395804.3 1815547 D 5061 CDS An12g07560 84592646 complement(join(1816981..1817036,1817239..1817484,1817604..1817722,1817800..1817889,1817980..1818092,1818195..1818341,1818415..1818486)) III 1 NT_166527.1 hypothetical protein 1818486 84592646 An12g07560 Aspergillus niger hypothetical protein XP_059604543.1 1816981 R 5061 CDS An12g07570 4986106 join(1819048..1819155,1819376..1819675) III 1 NT_166527.1 Function: SNC2 mediates the targeting and transport of secretory proteins.; Similarity: SNC2 is a homolog of the yeast SNC1 gene and of the vertebrate synaptic vesicle-associated membrane proteins synaptobrevin and VAMP.; Title: strong similarity to synaptobrevin Snc2 -Saccharomyces cerevisiae; intracellular transport vesicles; See PMID 8374953; uncharacterized protein 1819675 4986106 An12g07570 Aspergillus niger uncharacterized protein XP_001395806.3 1819048 D 5061 CDS An12g07580 4986107 join(1821443..1823857,1823921..1824161,1824228..1824283) III 1 NT_166527.1 Remark: N-Acetylglutamate kinase (AGK) and N-acetyl-gamma-glutamyl-phosphate reductase (AGPR) function as two separate mitochondrial enzymes, but are encoded by the single nuclear gene arg-6 in Neurospora crassa.; Title: strong similarity to acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase precursor arg-6 - Neurospora crassa; localisation:mitochondrion; See PMID 7907589; uncharacterized protein 1824283 4986107 An12g07580 Aspergillus niger uncharacterized protein XP_001395807.3 1821443 D 5061 CDS An12g07590 4986108 join(<1825560..1825594,1825660..1825800,1825868..1826002,1826072..1826558,1826616..1827185,1827247..1828017) III 1 NT_166527.1 Function: cohesin Rec8 is required for reductional chromosome segregation at meiosis.; Phenotype: when the rec8 gene is deleted, sister chromatids separate at meiosis I, resulting in equational rather than reductional chromosome segregation.; Remark: N-terminally truncated due to contig border.; Remark: the reductional segregation of the first stage of meiotic cell division (meiosis I) requires that sister chromatids remain associated through their centromeres and move together to the same pole.; Title: similarity to meiotic cohesin rec8p -Schizosaccharomyces pombe [truncated ORF]; See PMID 1339382; See PMID 10440376; uncharacterized protein 1828017 4986108 An12g07590 Aspergillus niger uncharacterized protein XP_059605548.1 1825560 D 5061 CDS An12g07600 4986109 join(1830130..1830198,1830290..1830784,1830854..1831174,1831234..1831528,1831586..1831614) III 1 NT_166527.1 Title: weak similarity to protein SEQ ID NO: 2310 from patent US6562958-B1 - Acinetobacter baumannii; uncharacterized protein 1831614 4986109 An12g07600 Aspergillus niger uncharacterized protein XP_001395809.1 1830130 D 5061 CDS An12g07610 84592647 complement(join(1832051..1832380,1832556..1832603)) III 1 NT_166527.1 hypothetical protein 1832603 84592647 An12g07610 Aspergillus niger hypothetical protein XP_059605549.1 1832051 R 5061 CDS An12g07620 4986111 complement(1833229..1834569) III 1 NT_166527.1 Title: strong similarity to hypothetical protein encoded by An15g05550 - Aspergillus niger; uncharacterized protein 1834569 4986111 An12g07620 Aspergillus niger uncharacterized protein XP_001395811.1 1833229 R 5061 CDS An12g07630 4986112 complement(join(1835794..1835801,1835856..1836109,1836162..1836585,1836642..1837054,1837104..1837392,1837452..1837761)) III 1 NT_166527.1 Catalytic activity: 2-methylisocitrate is converted to succinate and pyruvate by ICL2.; Induction: in glucose-limited cultures, growth with threonine as a nitrogen source results in a threefold induction of ICL2 mRNA levels and of 2-methylisocitrate lyase activity in cell extracts relative to cultures grown with ammonia as the nitrogen source.; Localization: 2-methylisocitrate lyase is located in the mitochondrial matrix.; Pathway: ICL2 catalyzes a step in the methylcitrate cycle of threonine catabolism.; Remark: the catalyzed reaction is similar to that catalyzed by isocitrate lyase.; Repression: transcription of ICL2 is subject to glucose catabolite repression.; Title: strong similarity to 2-methylisocitrate lyase Icl2 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 11092862; uncharacterized protein 1837761 4986112 An12g07630 Aspergillus niger uncharacterized protein XP_001395812.3 1835794 R 5061 CDS An12g07640 84592648 complement(join(1837998..1838108,1838231..1838266,1838566..1838724,1838795..1839152,1839435..1839465,1839536..1839659)) III 1 NT_166527.1 hypothetical protein 1839659 84592648 An12g07640 Aspergillus niger hypothetical protein XP_059605550.1 1837998 R 5061 CDS An12g07650 84592649 join(1841633..1841699,1841785..1841936,1841998..1842303) III 1 NT_166527.1 hypothetical protein 1842303 84592649 An12g07650 Aspergillus niger hypothetical protein XP_059605551.1 1841633 D 5061 CDS An12g07660 4986115 join(1842306..1842474,1842531..1842988,1843047..1843152,1843209..1843448,1843499..1844598) III 1 NT_166527.1 Catalytic activity: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate.; Function: asnB is involved in asparagine biosynthesis in vegetative cells.; Induction: in rich sporulation medium asnB is expressed only during exponential growth but is constitutively expressed in minimal medium.; Phenotype: deletion of asnB leads to a slow-growth phenotype, even in the presence of asparagine.; Remark: Bacillus subtilis has three asparagine synthetase genes, asnB, asnH, and asnO.; Title: strong similarity to asparagine synthase asnB - Bacillus subtilis; See PMID 10498721; uncharacterized protein 1844598 4986115 An12g07660 Aspergillus niger uncharacterized protein XP_059605552.1 1842306 D 5061 CDS An12g07670 4986116 complement(join(1844880..1845516,1845601..1845728)) III 1 NT_166527.1 Title: strong similarity to hypothetical lactam utilization protein lamB - Aspergillus nidulans; uncharacterized protein 1845728 4986116 An12g07670 Aspergillus niger uncharacterized protein XP_001395816.1 1844880 R 5061 CDS An12g07680 84592650 complement(join(1845854..1845924,1845977..1846057,1846107..1846231,1846284..1846364,1846431..1846618,1846711..1846822,1846958..1847072,1847127..1847259,1847381..1847542,1847667..1847684)) III 1 NT_166527.1 hypothetical protein 1847684 84592650 An12g07680 Aspergillus niger hypothetical protein XP_059605553.1 1845854 R 5061 CDS An12g07690 4986118 join(1847838..1848011,1848074..1848341,1848402..1850342,1850414..1850733) III 1 NT_166527.1 Function: LYS14 activates the transcription of at least four genes involved in lysine biosynthesis.; Induction: transcriptional activation by LYS14 is dependent on the inducer alpha-aminoadipate semialdehyde,an intermediate of the pathway.; Remark: LYS14 has a cysteine-rich DNA-binding motif of the Zn(II)2Cys6 type in its N-terminal portion.; Repression: LYS14 mediates repression by lysine.; Title: similarity to transcription activator of lysine pathway Lys14 - Saccharomyces cerevisiae; See PMID 7935367; uncharacterized protein 1850733 4986118 An12g07690 Aspergillus niger uncharacterized protein XP_059605554.1 1847838 D 5061 CDS An12g07695 84592651 1851343..1851600 III 1 NT_166527.1 hypothetical protein 1851600 84592651 An12g07695 Aspergillus niger hypothetical protein XP_059605555.1 1851343 D 5061 CDS An12g07700 4986120 join(1852280..1852377,1852469..1852700,1852775..1852801) III 1 NT_166527.1 Similarity: the predicted ORF shows strong similarity to Aspergillus oryzae EST SEQ ID NO:6167 of patent n. WO200056762-A2.; Title: weak similarity to hypothetical protein b2460 - Escherichia coli; uncharacterized protein 1852801 4986120 An12g07700 Aspergillus niger uncharacterized protein XP_001395820.1 1852280 D 5061 CDS An12g07710 4986121 join(1854281..1854848,1854899..1856213,1856266..1856353) III 1 NT_166527.1 Function: DBF20 of S. cerevisiae is involved in termination of M-phase.; Induction: the transcription of DBF20 of S. cerevisiae is not cell-cycle regulated.; Similarity: the predicted ORF and DBF20 of S. cerevisiae show strong similarity to Dbf2 and to other Ser/Thr protein kinases.; Title: strong similarity to protein kinase Dbf20 -Saccharomyces cerevisiae; See PMID 9613578; See PMID 1916278; See PMID 8131744; See PMID 8307336; See PMID 9528782; uncharacterized protein 1856353 4986121 An12g07710 Aspergillus niger uncharacterized protein XP_001395821.1 1854281 D 5061 CDS An12g07715 4986122 complement(join(1856543..1856623,1856696..1857025,1857108..1857122)) III 1 NT_166527.1 Title: weak similarity to hypothetical protein SPAC25B8.18 - Schizosaccharomyces pombe; uncharacterized protein 1857122 4986122 An12g07715 Aspergillus niger uncharacterized protein XP_001395822.1 1856543 R 5061 CDS An12g07720 4986123 complement(join(1857566..1858435,1858457..1859453,1859501..1859655)) III 1 NT_166527.1 Catalytic activity: NADH + 2 Fe3+ = NAD+ + 2 Fe2+.; Function: iron uptake in S. cerevisiae involves at least two steps: reduction of ferric to ferrous ions extracellularly and transport of the reduced ions through the plasma membrane; FRE2, together with FRE1, is shown to account for the total membrane-associated ferric reductase activity of the cell.; Induction: FRE2 of S. cerevisiae is induced by iron-deprivation like FRE1, but temporal regulation during growth differs from that of FRE1.; Title: strong similarity to ferric/cupric reductase Fre2 - Saccharomyces cerevisiae; plasma membrane; See PMID 9546033; See PMID 9726978; See PMID 8164662; See PMID 8940093; See PMID 9153234; uncharacterized protein 1859655 4986123 An12g07720 Aspergillus niger uncharacterized protein XP_059601888.1 1857566 R 5061 CDS An12g07730 4986124 join(1860346..1860830,1860861..1860864) III 1 NT_166527.1 Similarity: the aligment is over the first half of both proteins.; Title: weak similarity to copper transport protein COPT1 - Arabidopsis thaliana; See PMID 7499355; uncharacterized protein 1860864 4986124 An12g07730 Aspergillus niger uncharacterized protein XP_059601889.1 1860346 D 5061 CDS An12g07740 4986125 complement(join(1861723..1862780,1862844..1862977,1863030..1863142)) III 1 NT_166527.1 Remark: mithramycin is a glycosylated aromatic polyketide produced by Streptomyces argillaceus, and is used as an antitumor drug.; Remark: the mtmU gene from Streptomyces argillaceus codes for a 4-ketoreductase involved in D-oliose biosynthesis, and its inactivation resulted in the accumulation of premithramycinone and premithramycin A, the first glycosylated intermediate which contains a D-olivose unit.; Title: similarity to D-oliose 4-ketoreductase mtmU -Streptomyces argillaceus; See PMID 11254130; uncharacterized protein 1863142 4986125 An12g07740 Aspergillus niger uncharacterized protein XP_001395825.1 1861723 R 5061 CDS An12g07750 4986126 join(1864230..1864646,1864698..1864973) III 1 NT_166527.1 Title: similarity to hypothetical serine repeat antigen BAA78500.1 - Plasmodium falciparum; uncharacterized protein 1864973 4986126 An12g07750 Aspergillus niger uncharacterized protein XP_001395826.1 1864230 D 5061 CDS An12g07760 4986127 join(1866484..1866566,1866630..1866641,1866724..1866814,1866875..1866928,1866984..1867372,1867430..1867532) III 1 NT_166527.1 Catalytic activity: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.; Pathway: phospholipid degradation.; Remark: strong similarity to human lysophospholipase extended NHLP patent WO9849319-A1.; Title: strong similarity to lysophospholipase extended NHLP from patent WO9849319-A1 - Homo sapiens; uncharacterized protein 1867532 4986127 An12g07760 Aspergillus niger uncharacterized protein XP_001395827.1 1866484 D 5061 CDS An12g07770 4986128 complement(join(1867785..1868287,1868409..1868481,1868602..1868643)) III 1 NT_166527.1 Remark: similarity to Arabidopsis thaliana protein fragment SEQ ID NO: 6347 patent EP1033405-A2.; Title: similarity to protein fragment SEQ ID NO:6347 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 1868643 4986128 An12g07770 Aspergillus niger uncharacterized protein XP_059601890.1 1867785 R 5061 CDS An12g07780 4986129 join(1869137..1869305,1869370..1870208) III 1 NT_166527.1 Remark: strong similarity to human sequence 79 from patent EP1067182-A/79.; Similarity: to dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases).; Title: strong similarity to sequence 79 from patent EP1067182-A - Homo sapiens; uncharacterized protein 1870208 4986129 An12g07780 Aspergillus niger uncharacterized protein XP_001395829.1 1869137 D 5061 CDS An12g07790 4986130 join(1871349..1871394,1871798..1871971,1872051..1872298) III 1 NT_166527.1 Remark: BTF3 is a protein initially identified in HeLa cells that may be involved in the initiation of transcription. Although its specific role in transcription is unclear, BTF3 can form a stable complex with RNA polymerase II.; Remark: the ORF encoded protein shows also strong similarity to Aspergillus oryzae EST SEQ ID NO:4910.; Title: strong similarity to transcription factor btf3p - Schizosaccharomyces pombe; See PMID 8809106; uncharacterized protein 1872298 4986130 An12g07790 Aspergillus niger uncharacterized protein XP_059601891.1 1871349 D 5061 CDS An12g07800 4986131 complement(join(1873079..1876154,1876236..1877437)) III 1 NT_166527.1 Remark: most of the homologues are only the half of the length.; Title: strong similarity to hypothetical coronin-like protein SPAC11E3.05 - Schizosaccharomyces pombe; uncharacterized protein 1877437 4986131 An12g07800 Aspergillus niger uncharacterized protein XP_059601892.1 1873079 R 5061 CDS An12g07810 4986132 join(1878234..1878286,1878350..1878438,1878491..1878622,1878687..1878862) III 1 NT_166527.1 Catalytic activity: ATP + ubiquitin + protein lysine = AMP + pyrophosphate + protein N-ubiquityllysine.; Pathway: second step in ubiquitin conjugation.; Remark: strong similarity to human ubiquitin-conjugating enzyme 2 UCE2 patent CN1268564-A.; Remark: the human gene product expressed in Escherichia coli exhibited the ability to form a thiol ester linkage with ubiquitin in a ubiquitin-activating enzyme E1-dependent manner.; Similarity: to the Drosophila's bendless gene product.; Title: strong similarity to ubiquitin-conjugating enzyme 2 UCE2 from patent CN1268564-A - Homo sapiens; See PMID 8902611; uncharacterized protein 1878862 4986132 An12g07810 Aspergillus niger uncharacterized protein XP_001395832.1 1878234 D 5061 CDS An12g07820 84592652 join(1879669..1879691,1879787..1880226,1880301..1880524,1880582..1880962,1881020..1881280) III 1 NT_166527.1 hypothetical protein 1881280 84592652 An12g07820 Aspergillus niger hypothetical protein XP_059601893.1 1879669 D 5061 CDS An12g07830 4986134 join(1881629..1881679,1881828..1881971,1882273..1882557) III 1 NT_166527.1 Remark: ribosomal protein L32 regulates the splicing of the transcript of its own gene, RPL32.; Remark: strong similarity to EST an_2400 and an_3018 Aspergillus niger.; Similarity: belongs to the ribosomal protein L24E family.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L30 - Kluyveromyces lactis; cytoplasm; See PMID 2040015; 60S ribosomal protein eL24 1882557 4986134 An12g07830 Aspergillus niger 60S ribosomal protein eL24 XP_001395834.1 1881629 D 5061 CDS An12g07840 4986135 complement(join(1883645..1883734,1883811..1884248)) III 1 NT_166527.1 Catalytic activity: acetyl-CoA + D-glucosamine 6-phosphate = CoA + N-acetyl-D-glucosamine 6-phosphate.; Pathway: glutamate metabolism; aminosugars metabolism.; Remark: GNA1 (also known as PAT1) is required for multiple steps in the cell cycle, such as exit from G0,progression of DNA synthesis, and mitosis.; Remark: the recombinant yeast protein for YFL017C (GNA1) displayed phosphoglucosamine acetyltransferase activities in vitro and utilized glucosamine 6-phosphate as the substrate. GNA1, a member of the Gcn5-related N-acetyltransferase (GNAT) superfamily, participates in UDP-GlcNAc biosynthesis by catalyzing the formation of GlcNAc6P from AcCoA and GlcN6P.; Similarity: belongs to the family of acetyltransferases.; Title: strong similarity to glucosamine-phosphate N-acetyltransferase Gna1 - Saccharomyces cerevisiae; See PMID 9077451; See PMID 9867860; See PMID 11278591; uncharacterized protein 1884248 4986135 An12g07840 Aspergillus niger uncharacterized protein XP_059601894.1 1883645 R 5061 CDS An12g07850 4986136 complement(join(1885073..1885259,1885318..1886335,1886394..1886509,1886603..1886640,1886706..1886750,1886854..1887051)) III 1 NT_166527.1 Catalytic activity: (S)-malate = fumarate + H2O.; Pathway: citrate cycle (TCA cycle); reductive carboxylate cycle (CO2 fixation).; Remark: a splice site was detected upstream of the START codon.; Remark: the level of fumR RNA from R. oryzae increased in cells producing FA under stress conditions (high carbon and low nitrogen levels in the medium),suggesting that transcriptional regulation of fumR might be involved in the overproduction and accumulation of FA by Ro cells under stress conditions.; Similarity: belongs to the fumarate hydratase.; Title: strong similarity to fumarate hydratase fumR - Rhizopus oryzae; See PMID 7557464; uncharacterized protein 1887051 4986136 An12g07850 Aspergillus niger uncharacterized protein XP_001395836.3 1885073 R 5061 CDS An12g07860 4986137 complement(join(1887595..1887852,1887920..1888237,1888301..1888828)) III 1 NT_166527.1 Remark: also strong similarity to Sulfolobus solfataricus esterase P1-8LC patent WO9730160-A1.; Remark: strong similarity to EST SEQ ID NO:4009 from Aspergillus niger.; Title: strong similarity to esterase P1-8LC from patent WO9730160-A1 - Sulfolobus solfataricus; uncharacterized protein 1888828 4986137 An12g07860 Aspergillus niger uncharacterized protein XP_001395837.1 1887595 R 5061 CDS An12g07870 4986138 join(1890135..1891211,1891275..1891380,1891455..1891519) III 1 NT_166527.1 Catalytic activity: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.; Remark: alternative names are YLR027c, ASP5.; Remark: the gene AAT2 codes for the cytosolic and peroxisomal AAT activities. Disruption of the AAT2 gene did not affect growth on oleate. Furthermore beta-oxidation of palmitate was normal. AAT2 is not essential for the peroxisomal NAD(H) redox shuttle.; Similarity: belongs to the class-I of pyridoxal-phosphate-dependent aminotransferases.; Title: strong similarity to cytosolic aspartate transaminase Aat2 - Saccharomyces cerevisiae; See PMID 9288922; See PMID 9655342; uncharacterized protein 1891519 4986138 An12g07870 Aspergillus niger uncharacterized protein XP_001395838.1 1890135 D 5061 CDS An12g07880 4986139 complement(join(1892227..1893411,1893537..1893608)) III 1 NT_166527.1 Remark: CHS5 of S. cerevisiae is involved in chitin synthase III activity, also required for homozygosis in the first stages of mating.; Remark: Chs5p is required for the polarization of Chs3p. in wild-type cells, Chs3p is polarized as a diffuse ring at the incipient bud site and at the neck between the mother and bud in small-budded cells; it is not found at the neck in large-budded cells containing a single nucleus.; Remark: alternative names are CAL3, YLR330W.; Remark: the homologues proteins are C-terminally longer.; Title: strong similarity to chitin synthesis protein Chs5 - Saccharomyces cerevisiae; See PMID 9008706; See PMID 9111317; uncharacterized protein 1893608 4986139 An12g07880 Aspergillus niger uncharacterized protein XP_001395839.3 1892227 R 5061 CDS An12g07890 84592653 complement(1894115..1894660) III 1 NT_166527.1 hypothetical protein 1894660 84592653 An12g07890 Aspergillus niger hypothetical protein XP_059601895.1 1894115 R 5061 CDS An12g07900 4986141 join(1895269..1895289,1895538..1895966) III 1 NT_166527.1 Remark: shows strong similarity to EST an_3273 Aspergillus niger.; Remark: the small human eukaryotic initiation factor (eIF)-4C is implicated in the initiation pathway, where it enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(i) to 40 S ribosomal subunits.; Similarity: belongs to the eif-1a family.; Title: strong similarity to protein synthesis factor eIF-4C - Homo sapiens; See PMID 8106356; uncharacterized protein 1895966 4986141 An12g07900 Aspergillus niger uncharacterized protein XP_001395841.1 1895269 D 5061 CDS An12g07910 4986142 complement(join(1896641..1897558,1897609..1898710,1898762..1899238,1899289..1899340,1899400..1899470,1899520..1899607,1899677..1899854,1899929..1899976)) III 1 NT_166527.1 Remark: mus-38 participates in a different NER (nucleotide excision repair) pathway from that involving the mus-18 gene.; Similarity: to the yeast RAD1 protein.; Title: strong similarity to component of the nucleotide excision repairosome MUS38 - Neurospora crassa; See PMID 9560435; uncharacterized protein 1899976 4986142 An12g07910 Aspergillus niger uncharacterized protein XP_059601896.1 1896641 R 5061 CDS An12g07920 4986143 complement(join(1900387..1900448,1900511..1900661)) III 1 NT_166527.1 Remark: the ORF is short in length (70 amino acids).; hypothetical protein 1900661 4986143 An12g07920 Aspergillus niger hypothetical protein XP_001395843.1 1900387 R 5061 CDS An12g07930 84592654 join(1901712..1901935,1902000..>1903275) III 1 NT_166527.1 Remark: C-terminal truncated ORF due to end of contig.; Remark: yeast Las17 protein is homologous to the Wiskott-Aldrich Syndrome protein, which is implicated in severe immunodeficiency. Las17p/Bee1p has been shown to be important for actin patch assembly and actin polymerization.; Title: strong similarity to proline-rich protein Las17 - Saccharomyces cerevisiae [truncated ORF]; See PMID 9742397; See PMID 10512884; See PMID 10648568; See PMID 8105860; uncharacterized protein 1903275 84592654 An12g07930 Aspergillus niger uncharacterized protein XP_059601897.1 1901712 D 5061 CDS An12g07940 4986144 join(<1903379..1903715,1903769..1903800) III 1 NT_166527.1 Title: similarity to hypothetical protein Y48E1B.1 -Caenorhabditis elegans [truncated ORF]; uncharacterized protein 1903800 4986144 An12g07940 Aspergillus niger uncharacterized protein XP_001395844.3 1903379 D 5061 CDS An12g07950 4986146 join(1905064..1905663,1905731..1906359,1906421..1906925) III 1 NT_166527.1 Function: MRS2 of S. cerevisiae is essential for the excision of group II introns from mitochondrial transcripts in vivo.; Remark: MRS2 of S. cerevisiae is a nuclear encoded protein involved in mitochondrial biogenesis.; Title: strong similarity to mitochondrial RNA splicing protein Mrs2 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 1551905; uncharacterized protein 1906925 4986146 An12g07950 Aspergillus niger uncharacterized protein XP_001395846.1 1905064 D 5061 CDS An12g07960 4986147 complement(join(1907250..1907274,1907331..1907398,1907594..1909351)) III 1 NT_166527.1 Title: strong similarity to hypothetical protein YPL030w - Saccharomyces cerevisiae; uncharacterized protein 1909351 4986147 An12g07960 Aspergillus niger uncharacterized protein XP_001395847.3 1907250 R 5061 CDS An12g07970 84592655 complement(join(1909808..1909900,1909965..1910017,1910231..1910397,1910485..1910561)) III 1 NT_166527.1 hypothetical protein 1910561 84592655 An12g07970 Aspergillus niger hypothetical protein XP_059601898.1 1909808 R 5061 CDS An12g07980 84592656 complement(join(1910729..1910857,1910952..1911056,1911146..1911258,1911337..1911438,1911532..1911787,1911910..1912014,1912092..1912304)) III 1 NT_166527.1 hypothetical protein 1912304 84592656 An12g07980 Aspergillus niger hypothetical protein XP_059601899.1 1910729 R 5061 CDS An12g07990 84592657 complement(join(1915604..1915609,1915677..1915734,1915967..1916026,1916110..1916171,1916296..1916432,1916481..1916675,1916790..1916815,1916856..1916866)) III 1 NT_166527.1 Similarity: shows unspecific matches to Glu-rich domains of various proteins from diverse species.; hypothetical protein 1916866 84592657 An12g07990 Aspergillus niger hypothetical protein XP_059601900.1 1915604 R 5061 CDS An12g08000 4986151 join(1916881..1916914,1917083..1917203,1917261..1917301,1917364..1917793,1917858..1919481) III 1 NT_166527.1 Function: Pfam and COG motives suggest a putative ketopantoate reductase.; Title: strong similarity to hypothetical protein SPCC1902.02 - Schizosaccharomyces pombe; uncharacterized protein 1919481 4986151 An12g08000 Aspergillus niger uncharacterized protein XP_001395851.1 1916881 D 5061 CDS An12g08010 84592658 complement(join(1920087..1920215,1920421..1920504,1920562..1920620,1920695..1920898,1921049..1921055)) III 1 NT_166527.1 Title: weak similarity to homeobox protein HOXC13 -Homo sapiens; uncharacterized protein 1921055 84592658 An12g08010 Aspergillus niger uncharacterized protein XP_059601901.1 1920087 R 5061 CDS An12g08020 4986153 complement(join(1921168..1921234,1921288..1921503,1921626..1921889,1921980..1922155)) III 1 NT_166527.1 Pathway: phosphoglycerate mutase catalyzes the conversion of 3-phosphoglycerate to 2-phosphoglycerate (the substrate of enolase) in glycolysis and the reverse reaction in gluconeogenesis.; Title: strong similarity to hypothetical phosphoglycerate mutase YKR043c - Saccharomyces cerevisiae; uncharacterized protein 1922155 4986153 An12g08020 Aspergillus niger uncharacterized protein XP_001395853.1 1921168 R 5061 CDS An12g08030 4986154 complement(join(1922850..1922895,1922948..1923205,1923255..1923615,1923668..1924078,1924676..1924922)) III 1 NT_166527.1 Function: SUB2 of S. cerevisiae is essential for prespliceosome formation.; Remark: the systematic gene name of SUB2 of S. cerevisiae is YDL084w.; Similarity: belongs to the DEAD-box family of ATP-dependent RNA helicases.; Similarity: belongs to the superfamily II of DNA and RNA helicases.; Title: strong similarity to NADH oxidoreductase complex I subunit Sub2 - Saccharomyces cerevisiae; nucleus; See PMID 11156604; uncharacterized protein 1924922 4986154 An12g08030 Aspergillus niger uncharacterized protein XP_001395854.1 1922850 R 5061 CDS An12g08040 4986155 1925363..1925971 III 1 NT_166527.1 Complex: ribonuclease P of H. sapiens is a ribonucleoprotein complex with several protein subunits.; Function: ribonuclease P of H. sapiens is involved in tRNA processing in the nucleus.; Title: similarity to hypothetical ribonuclease P subunit Rpp21 - Homo sapiens; uncharacterized protein 1925971 4986155 An12g08040 Aspergillus niger uncharacterized protein XP_001395855.1 1925363 D 5061 CDS An12g08050 84592659 complement(1926901..1927275) III 1 NT_166527.1 Title: strong similarity to EST an_2641 -Aspergillus niger; uncharacterized protein 1927275 84592659 An12g08050 Aspergillus niger uncharacterized protein XP_059601902.1 1926901 R 5061 CDS An12g08060 4986157 complement(join(1927294..1927524,1927692..1927967)) III 1 NT_166527.1 Similarity: shows similarity to 5'-ESTs of the A. nidulans cDNA clones r2e05a1 and m7g05a1.; Title: strong similarity to hypothetical protein CAE76529.1 - Neurospora crassa; uncharacterized protein 1927967 4986157 An12g08060 Aspergillus niger uncharacterized protein XP_001395857.1 1927294 R 5061 CDS An12g08070 84592660 join(1928247..1928302,1928381..1928415,1928458..1928599,1928683..1928714,1928836..1928900) III 1 NT_166527.1 hypothetical protein 1928900 84592660 An12g08070 Aspergillus niger hypothetical protein XP_059601903.1 1928247 D 5061 CDS An12g08080 84592661 complement(join(1929000..1929194,1929284..1929346,1929506..1929655)) III 1 NT_166527.1 hypothetical protein 1929655 84592661 An12g08080 Aspergillus niger hypothetical protein XP_059601904.1 1929000 R 5061 CDS An12g08090 4986160 1929889..1930773 III 1 NT_166527.1 Title: weak similarity to actin filament-binding protein b-nexilin - Rattus norvegicus; See PMID 9832551; uncharacterized protein 1930773 4986160 An12g08090 Aspergillus niger uncharacterized protein XP_001395860.1 1929889 D 5061 CDS An12g08100 4986161 complement(join(1931653..1933629,1933688..1933740,1933809..1933860)) III 1 NT_166527.1 Function: nimA of A. nidulans is involved in cell cycle control and chromatin condensation.; Function: the kinase activity of nimA of A. nidulans has not been demonstrated experimentally.; Phenotype: overexpression of nimA in A. nidulans causes mitotic induction.; Similarity: also shows similarity to other protein kinases.; Similarity: an N-terminal fragment of nimA of A. nidulans is subject of the protein patent WO9966051-A2 (PATENTPROT:AAY59147).; Title: strong similarity to serine/threonine protein kinase nimA - Aspergillus nidulans; See PMID 3359487; uncharacterized protein 1933860 4986161 An12g08100 Aspergillus niger uncharacterized protein XP_001395861.1 1931653 R 5061 CDS An12g08110 4986162 join(1934513..1934749,1934814..1934899,1934969..1935960,1936015..1936562) III 1 NT_166527.1 Similarity: contains ankyrin-repeat and BPOZ-domain-like regions which are thought to mediate protein-protein interactions.; Similarity: shows homology to the protein patent database entry PATENTPROT:AAB64399.; Title: strong similarity to intracellular signalling protein INTRA31 from patent WO200077040-A2 - Homo sapiens; uncharacterized protein 1936562 4986162 An12g08110 Aspergillus niger uncharacterized protein XP_059601905.1 1934513 D 5061 CDS An12g08120 84592662 complement(join(1936687..1936801,1936889..1936970,1937008..1937272)) III 1 NT_166527.1 hypothetical protein 1937272 84592662 An12g08120 Aspergillus niger hypothetical protein XP_059601906.1 1936687 R 5061 CDS An12g08130 84592663 join(1937865..1937870,1937915..1938082) III 1 NT_166527.1 Title: questionable ORF; uncharacterized protein 1938082 84592663 An12g08130 Aspergillus niger uncharacterized protein XP_059601907.1 1937865 D 5061 CDS An12g08140 84592664 complement(join(1938493..1938760,1938857..1939072,1939123..1939274,1939329..1939468,1939559..1939624,1939730..1939841)) III 1 NT_166527.1 hypothetical protein 1939841 84592664 An12g08140 Aspergillus niger hypothetical protein XP_059601908.1 1938493 R 5061 CDS An12g08150 84592665 complement(join(1939960..1940046,1940149..1940271,1940385..1940446,1940562..1940660,1940741..1940804,1940893..1941009)) III 1 NT_166527.1 hypothetical protein 1941009 84592665 An12g08150 Aspergillus niger hypothetical protein XP_059601909.1 1939960 R 5061 CDS An12g08160 84592666 complement(join(1941576..1941687,1941861..1941889)) III 1 NT_166527.1 Title: questionable ORF; uncharacterized protein 1941889 84592666 An12g08160 Aspergillus niger uncharacterized protein XP_059601910.1 1941576 R 5061 CDS An12g08170 84592667 complement(join(1943201..1943333,1943384..1943443,1943515..1943648,1943727..1943793,1943842..1943879)) III 1 NT_166527.1 Remark: shep-GRP of C. bursa-pastoris is a precursor polypeptide for two glycine/histidine-rich peptides,shepherins I (28 aa) and II (38 aa).; Similarity: the homology region covers the complete shepherin I sequence.; Title: weak similarity to antimicrobial peptide precursor shep-GRP - Capsella bursapastoris; See PMID 11117262; uncharacterized protein 1943879 84592667 An12g08170 Aspergillus niger uncharacterized protein XP_059601911.1 1943201 R 5061 CDS An12g08180 84592668 join(1944855..1944940,1945063..1945139,1945223..1945327,1945626..1945838,1945927..1945982,1946361..1946450,1946612..1946728,1946798..1946863,1946935..1947175,1947407..1947484,1947588..1947734,1947878..1947954,1948052..1948150) III 1 NT_166527.1 hypothetical protein 1948150 84592668 An12g08180 Aspergillus niger hypothetical protein XP_059601912.1 1944855 D 5061 CDS An12g08190 84592669 complement(join(1948748..1948897,1948940..1948952,1949033..1949152,1949180..1949310)) III 1 NT_166527.1 hypothetical protein 1949310 84592669 An12g08190 Aspergillus niger hypothetical protein XP_059601913.1 1948748 R 5061 CDS An12g08200 84592670 complement(join(1950922..1951009,1951070..1951259,1951483..1951697,1951802..1951902)) III 1 NT_166527.1 hypothetical protein 1951902 84592670 An12g08200 Aspergillus niger hypothetical protein XP_059601914.1 1950922 R 5061 CDS An12g08210 84592671 complement(join(1951975..1952173,1952203..1952218,1952323..1952371)) III 1 NT_166527.1 Similarity: the C-terminus shows similarity to a conserved domain of transcription factors of the Brn-3b family.; Title: questionable ORF; uncharacterized protein 1952371 84592671 An12g08210 Aspergillus niger uncharacterized protein XP_059601915.1 1951975 R 5061 CDS An12g08220 84592672 join(1953341..1953393,1953469..1953949) III 1 NT_166527.1 hypothetical protein 1953949 84592672 An12g08220 Aspergillus niger hypothetical protein XP_059601916.1 1953341 D 5061 CDS An12g08230 4986174 join(1955939..1956200,1956275..1956990) III 1 NT_166527.1 Remark: the initiation of conidiophore development in the filamentous fungus Aspergillus nidulans is a complex process requiring the activities of several genes including fluG, flbA, flbB, flbC, flbD, and flbE. Recessive mutations in any one of these genes result in greatly reduced expression of the brlA developmental regulatory gene and a colony morphology described as fluffy. These fluffy mutants have somewhat diverse phenotypes but generally grow as undifferentiated masses of vegetative hyphae to form large cotton-like colonies.; Title: strong similarity to zinc-finger protein flbC - Aspergillus nidulans; See PMID 9339347; See PMID 8978035; uncharacterized protein 1956990 4986174 An12g08230 Aspergillus niger uncharacterized protein XP_001395874.1 1955939 D 5061 CDS An12g08240 4986175 complement(join(1958044..1958088,1958123..1958138,1958224..1958315,1958680..1959738,1959788..1959915,1959968..1960040,1960100..1960987,1961037..1961948,1962005..1963015)) III 1 NT_166527.1 Remark: similarity to HTRM (human transcriptional regulatory molecule) clone 2674047 patent WO9957144-A2.; Title: similarity to human transcriptional regulatory protein from patent WO9957144-A2 - Homo sapiens; uncharacterized protein 1963015 4986175 An12g08240 Aspergillus niger uncharacterized protein XP_001395875.3 1958044 R 5061 CDS An12g08250 4986176 join(1963438..1963551,1963647..1963832) III 1 NT_166527.1 hypothetical protein 1963832 4986176 An12g08250 Aspergillus niger hypothetical protein XP_001395876.1 1963438 D 5061 CDS An12g08260 4986177 complement(join(1964592..1967636,1967695..1968054)) III 1 NT_166527.1 Remark: all other found homologues are shorter in lenght.; Remark: similarity to amino acid sequence of a human hydrolytic enzyme HYENZ8 patent WO200116334-A.; Title: similarity to C-terminus of a human hydrolytic enzyme HYENZ8 from patent WO200116334-A2 - Homo sapiens; uncharacterized protein 1968054 4986177 An12g08260 Aspergillus niger uncharacterized protein XP_001395877.1 1964592 R 5061 CDS An12g08270 4986178 complement(join(1968619..1968956,1969009..1969651,1969713..1969734,1969815..1970023)) III 1 NT_166527.1 Catalytic activity: (S)-lactate + O2 = acetate + CO2 + H2O.; Pathway: pyruvate metabolism.; Remark: L-Lactate 2-monooxygenase catalyzes the oxidation of L-lactate to acetate and carbon dioxide.; Similarity: belongs to the FMN-dependent alpha-hydroxy acid dehydrogenases family.; Title: strong similarity to L-lactate 2-monooxygenase LA2M - Mycobacterium smegmati; See PMID 2324094; See PMID 3571231; uncharacterized protein 1970023 4986178 An12g08270 Aspergillus niger uncharacterized protein XP_001395878.1 1968619 R 5061 CDS An12g08280 4986179 complement(join(1970364..1971584,1971645..1972037)) III 1 NT_166527.1 Catalytic activity: hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides; Function: the exo-inulinase inu1 from A. niger hydrolyses inulin and levan.; Gene-ID: inu1; Pathway: galactose metabolism; starch and sucrose metabolism.; Remark: Sucrose-inducible secretory sucrose:sucrose 1-fructosyltransferase (1-SST) from Aspergillus foetidus is extensively glycosylated, and the active form is probably represented by a dimer of identical subunits with an apparent molecular mass of 180 kDa. Expression of the cloned gene in an invertase-deficient mutant of S. cerevisiae resulted in 1-kestose production, with 6-kestose and neokestose being side products of the reaction.; Remark: identical to DNA and protein sequence of sucrose:sucrose 1-fructosyltransferase from Aspergillus foetidus.; Similarity: belongs to family 32 of glycosyl hydrolases.; See PMID 9495772; exo-inulinase inu1-Aspergillus niger 1972037 inu1 4986179 inu1 Aspergillus niger exo-inulinase inu1-Aspergillus niger XP_001395879.1 1970364 R 5061 CDS An12g08290 84592673 complement(join(1973372..1973465,1973577..1973729,1973798..1973820)) III 1 NT_166527.1 hypothetical protein 1973820 84592673 An12g08290 Aspergillus niger hypothetical protein XP_059601917.1 1973372 R 5061 CDS An12g08300 84592674 join(1974000..1974006,1974195..1974545,1974600..1975111) III 1 NT_166527.1 Title: similarity to hypothetical protein encoded by An04g09580 - Aspergillus niger; uncharacterized protein 1975111 84592674 An12g08300 Aspergillus niger uncharacterized protein XP_059601918.1 1974000 D 5061 CDS An12g08310 84592675 complement(join(1975636..1975806,1975897..1975952,1976047..1976127,1976222..1976288,1976352..1976480,1976614..1976745)) III 1 NT_166527.1 hypothetical protein 1976745 84592675 An12g08310 Aspergillus niger hypothetical protein XP_059601919.1 1975636 R 5061 CDS An12g08320 4986183 join(1977047..1977127,1977223..1977349,1977517..1977717,1977798..1977898,1977955..1978102,1978154..1979199) III 1 NT_166527.1 Function: the S. cerevisiae Tna1 transporter is involved in the uptake of nicotinic acid.; Remark: alternate name for S. cerevisiae Tna1: YGR260W.; Similarity: belongs to the permeases of the major facilitator superfamily.; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563; See PMID 10984621; uncharacterized protein 1979199 4986183 An12g08320 Aspergillus niger uncharacterized protein XP_001395883.3 1977047 D 5061 CDS An12g08330 84592676 join(1980088..1980263,1980358..1980514) III 1 NT_166527.1 hypothetical protein 1980514 84592676 An12g08330 Aspergillus niger hypothetical protein XP_059601920.1 1980088 D 5061 CDS An12g08340 4986185 join(1981308..1981390,1981460..1982633) III 1 NT_166527.1 Title: strong similarity to hypothetical protein B2J23.50 - Neurospora crassa; uncharacterized protein 1982633 4986185 An12g08340 Aspergillus niger uncharacterized protein XP_001395885.1 1981308 D 5061 CDS An12g08350 4986186 complement(join(1983207..1983620,1983689..1983819,1983873..1984167,1984302..1984681,1984747..1984903,1984964..1985019,1985058..1985151,1985224..1985367)) III 1 NT_166527.1 Phenotype: disruption of TRI12 of F. sporotrichioides results in both reduced growth on complex media and reduced levels of trichothecene production.; Remark: growth of TRI12 mutants on trichothecene-containing media is inhibited, suggesting that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.; Remark: trichothecenes are sesquiterpenoid mycotoxins and act as protein synthesis inhibitors for eukaryotic organisms.; Title: strong similarity to trichothecene efflux pump TRI12 - Fusarium sporotrichioides; See PMID 10485289; uncharacterized protein 1985367 4986186 An12g08350 Aspergillus niger uncharacterized protein XP_059601921.1 1983207 R 5061 CDS An12g08360 4986187 complement(join(1986227..1986604,1986687..1987223)) III 1 NT_166527.1 Title: similarity to hypothetical protein YER182w -Saccharomyces cerevisiae; uncharacterized protein 1987223 4986187 An12g08360 Aspergillus niger uncharacterized protein XP_001395887.3 1986227 R 5061 CDS An12g08370 4986188 complement(join(1987429..1987490,1987557..1989203,1989275..1989290)) III 1 NT_166527.1 Catalytic activity: UBP6 of S. cerevisiae preferentially hydrolyzes ubiquitin-carboxy-terminal alpha-NH-protein extensions.; Function: UBP6 of S. cerevisiae is probably involved in the deubiquitination of polyubiquitinated proteins targeted for proteasomal degradation.; Function: UBP6 of S. cerevisiae probably plays an important role in the generation of free ubiquitin and ribosomal proteins from ubiquitin-ribosomal protein fusions.; Remark: the systematic gene name of UBP6 in S. cerevisiae is YFR010w.; Similarity: UBP6 of S. cerevisiae belongs to the ubiquitin carboxyl-terminal hydrolases family 2 (also known as peptidase family C19).; Similarity: also shows strong similarity to queuine tRNA-ribosyltransferase (tRNA-guanine transglycosylase,guanine insertion enzyme; EC 2. 4. 2. 29) of various species.; Similarity: contains a ubiquitin-like domain in the N-terminal part.; Similarity: the 3'-part of the ORF is nearly identical to a 5'-EST of the A. niger cDNA clone 3200 (EMBLEST:BE758940).; Title: strong similarity to ubiquitin specific protease Ubp6 - Saccharomyces cerevisiae; See PMID 9344467; See PMID 10386876; See PMID 8982460; uncharacterized protein 1989290 4986188 An12g08370 Aspergillus niger uncharacterized protein XP_001395888.1 1987429 R 5061 CDS An12g08380 4986189 join(1990002..1990004,1990060..1990154,1990223..1990537,1990607..1990649,1990705..1990749,1990798..1990806) III 1 NT_166527.1 Complex: p20-Arc of H. sapiens forms part of the heteroheptameric Arp2/3 complex composed of Arp2, Arp3,p41-Arc, p34-Arc, p21-Arc, p20-Arc, and p16-Arc.; Function: the Arp2/3 complex of H. sapiens promotes actin polymerization in lamellipodia of motile cells and participates in lamellipodial protrusion.; Localization: the Arp2/3 complex of H. sapiens is localized to the actin-rich lamellipodia at the leading edge of motile cells.; Similarity: the 5'-part of the ORF shows strong similarity to a 5'-EST of the A. niger cDNA clone 3082 (EMBLEST:BE758834).; Title: strong similarity to Arp2/3 complex subunit p20-Arc - Homo sapiens; cytoskeleton; See PMID 9230079; uncharacterized protein 1990806 4986189 An12g08380 Aspergillus niger uncharacterized protein XP_001395889.1 1990002 D 5061 CDS An12g08390 4986190 join(1991714..1992148,1992201..1992608,1992663..1992725,1992773..1993081,1993179..1993685) III 1 NT_166527.1 Complex: hnRNP F in H. sapiens forms part of hnRNP complexes associated with pre-mRNAs containing guanosine-rich sequences.; Function: hnRNP F in H. sapiens is involved in the processing of mRNAs containing guanosine-rich sequences.; Localization: hnRNP F in H. sapiens is concentrated in discrete regions of the nucleoplasm.; Title: similarity to heterogeneous nuclear ribonucleoprotein hnRNP F - Homo sapiens; See PMID 7512260; uncharacterized protein 1993685 4986190 An12g08390 Aspergillus niger uncharacterized protein XP_001395890.3 1991714 D 5061 CDS An12g08400 4986191 complement(join(1994208..1994738,1994963..1995439)) III 1 NT_166527.1 Similarity: the 3'-part of the ORF shows strong similarity to a 3'-EST of the A. niger cDNA clone 1672 (EMBLEST:BE760426).; Title: strong similarity to hypothetical protein YGL050w - Saccharomyces cerevisiae; uncharacterized protein 1995439 4986191 An12g08400 Aspergillus niger uncharacterized protein XP_001395891.1 1994208 R 5061 CDS An12g08410 84592677 join(1995547..1995643,1995814..1996100,1996190..1996306,1996435..1996602,1996660..1996673,1996765..1996870) III 1 NT_166527.1 Similarity: also shares some homology with the C-terminal part of the Alpha-ketoglutarate dehydrogenase E1 subunit of patent GENESEQPROT:Y32087.; Title: weak similarity to hypothetical transcription factor MBK20.16 - Arabidopsis thaliana; uncharacterized protein 1996870 84592677 An12g08410 Aspergillus niger uncharacterized protein XP_059601922.1 1995547 D 5061 CDS An12g08420 84592678 complement(join(1997916..1998070,1998222..1998352,1998495..1998565,1998654..1998799,1998861..1999013,1999154..1999229,1999497..1999610,1999654..1999771,1999841..1999895,1999977..2000137,2000224..2000389,2000848..2000917,2001038..2001138,2001245..2001371)) III 1 NT_166527.1 hypothetical protein 2001371 84592678 An12g08420 Aspergillus niger hypothetical protein XP_059601923.1 1997916 R 5061 CDS An12g08430 84592679 complement(join(2001945..2002054,2002162..2002432,2002529..2002597,2002651..2002944,2003023..2003088)) III 1 NT_166527.1 Title: weak similarity to hypothetical protein PA2750 - Pseudomonas aeruginosa; uncharacterized protein 2003088 84592679 An12g08430 Aspergillus niger uncharacterized protein XP_059601924.1 2001945 R 5061 CDS An12g08440 84592680 join(2003120..2003251,2003355..2003469,2003766..2003807,2003909..2004126,2004153..2004254) III 1 NT_166527.1 Title: weak similarity to hypothetical protein gom -Drosophila melanogaster; uncharacterized protein 2004254 84592680 An12g08440 Aspergillus niger uncharacterized protein XP_059601925.1 2003120 D 5061 CDS An12g08450 84592681 complement(join(2004276..2004341,2004401..2004588,2005001..2005045,2005142..2005247,2005273..2005419)) III 1 NT_166527.1 hypothetical protein 2005419 84592681 An12g08450 Aspergillus niger hypothetical protein XP_059601926.1 2004276 R 5061 CDS An12g08460 84592682 join(2005681..2005741,2005924..2006141) III 1 NT_166527.1 Function: the products of patent GENESEQPROT:Y07772 are useful for diagnosis, prevention, treatment or amelioration of medical conditions by means of e. g. protein or gene therapy.; Remark: protein patent GENESEQPROT:Y07772 describes human genes and their protein products.; Title: weak similarity to human secreted protein 29 from patent WO9909155-A1 - Homo sapiens; uncharacterized protein 2006141 84592682 An12g08460 Aspergillus niger uncharacterized protein XP_059601927.1 2005681 D 5061 CDS An12g08470 84592683 complement(join(2006298..2006468,2006542..2006759,2006804..2006880,2007052..2007086)) III 1 NT_166527.1 hypothetical protein 2007086 84592683 An12g08470 Aspergillus niger hypothetical protein XP_059601928.1 2006298 R 5061 CDS An12g08480 84592684 complement(join(2007163..2007167,2007262..2007294,2007351..2007522,2007725..2007898,2008343..2008506,2008585..2008762)) III 1 NT_166527.1 hypothetical protein 2008762 84592684 An12g08480 Aspergillus niger hypothetical protein XP_059601929.1 2007163 R 5061 CDS An12g08490 84592685 join(2009060..2009137,2009288..2009363,2009395..2009522,2009613..2009834,2010033..2010076,2010107..2010152,2010407..2010423,2010482..2010526,2010669..2010693,2010747..2010839,2010923..2010961) III 1 NT_166527.1 hypothetical protein 2010961 84592685 An12g08490 Aspergillus niger hypothetical protein XP_059601930.1 2009060 D 5061 CDS An12g08500 84592686 complement(join(2011744..2011797,2012054..2012068,2012121..2012330)) III 1 NT_166527.1 Title: questionable ORF; uncharacterized protein 2012330 84592686 An12g08500 Aspergillus niger uncharacterized protein XP_059601931.1 2011744 R 5061 CDS An12g08510 4986202 join(2014583..2014765,2014955..2015233,2015330..2015635,2015701..2016108) III 1 NT_166527.1 Similarity: contains a putative fungal Zn(2)-Cys(6)-type DNA-binding domain.; Similarity: shows unspecific matches to diverse proline-rich proteins of various species.; Title: similarity to hypothetical protein encoded by An11g02690 - Aspergillus niger; uncharacterized protein 2016108 4986202 An12g08510 Aspergillus niger uncharacterized protein XP_001395902.1 2014583 D 5061 CDS An12g08520 84592687 join(2016516..2016582,2016765..2017209,2017460..2017485,2017790..2017885,2018091..2018125) III 1 NT_166527.1 hypothetical protein 2018125 84592687 An12g08520 Aspergillus niger hypothetical protein XP_059601932.1 2016516 D 5061 CDS An12g08530 4986204 complement(join(2018432..2018607,2018735..2019040,2019093..2020909,2020991..2021044,2021138..>2021361)) III 1 NT_166527.1 Function: Hsl1p in S. cerevisiae is involved in Swe1p-targeting for degradation during the G2/M transition.; Function: Hsl1p in S. cerevisiae is part of the septin-dependent morphogenesis checkpoint for the G2/M-transition.; Function: Hsl1p in S. cerevisiae is required for Swe1p localization to the bud neck septin ring.; Function: Hsl1p in S. cerevisiae requires septins and Hsl7p binding for proper targeting of Swe1p.; Localization: Hsl1p in S. cerevisiae colocalizes with Hsl7p and Swe1p to the daughter side of the mother bud neck.; Pathway: Hsl1p in S. cerevisiae down-regulates Swe1p which in turn is an inhibitor of Cdc28.; Phenotype: disruption of HSL1 in S. cerevisiae is synthetically lethal in combination with a deletion of the amino terminus of histone H3.; Phenotype: disruption of HSL1 in S. cerevisiae leads to a Swe1p-mediated G2 delay.; Remark: HSL1 in S. cerevisiae is also called NIK1.; Remark: the ORF is N-terminally truncated due to end of contig.; Remark: the systematic name of HSL1 in S. cerevisiae is YKL101w.; Title: similarity to Swe1 regulating protein kinase Hsl1 - Saccharomyces cerevisiae [truncated ORF]; See PMID 10805747; See PMID 8647431; uncharacterized protein 2021361 4986204 An12g08530 Aspergillus niger uncharacterized protein XP_059601933.1 2018432 R 5061 CDS An12g08540 84592688 complement(<2021474..2022004) III 1 NT_166527.1 Function: together with Hsl7, the Hsl1 protein kinase induces the degradation of the Swe1 protein kinase. Hsl1p and Hsl7p interact directly with Swe1 to promote its recognition by the ubiquitination complex. Hsl1 is a negative regulator for Swe1. Swe1 phosphorylates Cdc2-type cyclin-dependent kinases (Cdc28p in S. cerevisiae). Morphogenesis influences cell-cycle and nuclear division. A cell cycle delay induced by the morphogenesis checkpoint requires Swe1p.; Remark: C-terminally truncated ORF due to the end of contig.; Remark: alternate names for S. cerevisiae Hsl1: YKL101W, Nik1.; Title: strong similarity to Swe1 regulating protein kinase Hsl1 - Saccharomyces cerevisiae [truncated ORF]; See PMID 10490630; See PMID 10679396; See PMID 11230131; uncharacterized protein 2022004 84592688 An12g08540 Aspergillus niger uncharacterized protein XP_059601934.1 2021474 R 5061 CDS An12g08550 4986206 complement(join(2023465..2023858,2024149..2024228)) III 1 NT_166527.1 Title: strong similarity to hypothetical protein AAC25763.1 - Streptomyces lividans; uncharacterized protein 2024228 4986206 An12g08550 Aspergillus niger uncharacterized protein XP_001395906.1 2023465 R 5061 CDS An12g08560 4986207 join(2025450..2025668,2025719..2025908,2025961..2026242,2026381..2027193,2027240..2027330,2027389..2027449,2027510..2027728) III 1 NT_166527.1 Title: strong similarity to proteinase SlpE -Streptomyces lividans; See PMID 7592364; uncharacterized protein 2027728 4986207 An12g08560 Aspergillus niger uncharacterized protein XP_059601935.1 2025450 D 5061 CDS An12g08570 4986208 join(2029808..2029857,2030021..2030297,2030356..2030499,2030557..2030592) III 1 NT_166527.1 Function: Peroxidases of the peroxiredoxin (Prx) family catalyze the reduction of H(2)O(2) and lipid peroxides.; Title: similarity to type 2 peroxiredoxin PrxII -Brassica napus; peroxisome; See PMID 10329461; uncharacterized protein 2030592 4986208 An12g08570 Aspergillus niger uncharacterized protein XP_001395908.1 2029808 D 5061 CDS An12g08580 4986209 join(2031201..2031533,2031616..2033913) III 1 NT_166527.1 Catalytic activity: the yeast RNAseP shows endonucleolytic cleavage activity for RNA, removing 5'-extra-nucleotide from a tRNA precursor.; Complex: the yeast RNAseP consists of a RNA moiety and at least 8 protein subunits: Pop1, Pop3, Pop4, Pop5,Pop6, Pop7, Pop8 and Ppp1.; Function: the Pop1 gene product from S. cerevisiae is required for processing of 5. 8s rRNA (short form) at site A3 and for 5' and 3' processing of pre-tRNA.; Title: strong similarity to ribonuclease P chain Pop1 - Saccharomyces cerevisiae; nucleus; See PMID 7926742; uncharacterized protein 2033913 4986209 An12g08580 Aspergillus niger uncharacterized protein XP_001395909.1 2031201 D 5061 CDS An12g08590 4986210 complement(join(2034270..2034794,2034861..2034918,2035156..2035214)) III 1 NT_166527.1 Title: similarity to hypothetical protein YFR011c -Saccharomyces cerevisiae; uncharacterized protein 2035214 4986210 An12g08590 Aspergillus niger uncharacterized protein XP_001395910.1 2034270 R 5061 CDS An12g08600 84592689 complement(2036244..2036792) III 1 NT_166527.1 Remark: this ORF overlaps with an EST that belongs to the following A. niger glkA gene.; Title: questionable ORF; uncharacterized protein 2036792 84592689 An12g08600 Aspergillus niger uncharacterized protein XP_059601936.1 2036244 R 5061 CDS An12g08610 4986212 join(2037174..2037356,2037416..2038720) III 1 NT_166527.1 Catalytic activity: ATP + D-glucose <=> ADP + D-glucose 6-phosphate.; Function: the glucokinase GlkA from A. niger has great affinity for glucose. Mannose, 2-deoxyglucose and glucosamine can serve as substrates. Its activity is relatively constant between pH 7. 5 and pH 9. 0. below pH 7. 5, the activity decreases with pH.; Gene-ID: GlkA; Pathway: Glycolysis.; cytoplasm; See PMID 8856049; glucokinase glkA-Aspergillus niger 2038720 GlkA 4986212 GlkA Aspergillus niger glucokinase glkA-Aspergillus niger XP_001395912.1 2037174 D 5061 CDS An12g08620 4986213 join(2039854..2040144,2040192..2040998,2041050..2041697) III 1 NT_166527.1 Remark: Botryotinia fuckeliana=Botrytis cinerea.; Similarity: the Bcmfs1 protein from Botryotinia fuckeliana belongs to the major facilitator family of transporters.; Title: strong similarity to MFS drug transporter Bcmfs1 - Botryotinia fuckeliana; plasma membrane; See PMID 11374155; uncharacterized protein 2041697 4986213 An12g08620 Aspergillus niger uncharacterized protein XP_001395913.1 2039854 D 5061 CDS An12g08630 4986214 complement(join(2043266..2044159,2044208..2044798,2044890..2044967)) III 1 NT_166527.1 Function: TRI11 (F. s.) catalyzes the hydroxylation at C-15 of isotricodermin.; Pathway: the TRI11 enzyme from F. sporotrichioides is involved trichothecene biosynthesis. Trichothecenes are sesquiterpenoid toxins that act by inhibiting protein biosynthesis.; Similarity: TRI11 (F. s.) belongs to the cytochrome p450 family.; Title: strong similarity to cytochrome P450 monooxygenase TRI11 - Fusarium sporotrichioides; See PMID 9435078; uncharacterized protein 2044967 4986214 An12g08630 Aspergillus niger uncharacterized protein XP_001395914.1 2043266 R 5061 CDS An12g08640 4986215 complement(2045885..2047456) III 1 NT_166527.1 Function: mammalian ASC-1 is involved in transcriptional activation.; Remark: the mammalian ASC-1 protein is a coactivator molecule of nuclear receptors which functions in conjunction with CBP-p300 and SRC-1.; Title: similarity to transcription coactivator ASC-1 - Mus musculus; nucleus; See PMID 10454579; uncharacterized protein 2047456 4986215 An12g08640 Aspergillus niger uncharacterized protein XP_001395915.1 2045885 R 5061 CDS An12g08650 4986216 complement(join(2048506..2049426,2049506..2049571)) III 1 NT_166527.1 Remark: the E. nidulans ptaC mRNA can become alternatively spliced.; Title: strong similarity to hypothetical transcriptional activator ptaC - Aspergillus nidulans; uncharacterized protein 2049571 4986216 An12g08650 Aspergillus niger uncharacterized protein XP_001395916.1 2048506 R 5061 CDS An12g08660 4986217 2050632..2051780 III 1 NT_166527.1 Title: weak similarity to protein fragment SEQ ID NO: 16694 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 2051780 4986217 An12g08660 Aspergillus niger uncharacterized protein XP_001395917.1 2050632 D 5061 CDS An12g08670 4986218 join(2053125..2053370,2053485..2053664,2053788..2053997,2054115..2054336) III 1 NT_166527.1 Complex: S. cerevisiae Rrp42 is an 'exosome' 3->5 exoribonuclease complex component with Rrp4, Rrp41, Rrp43 and Dis3 (Rrp44); Function: this S. cerevisiae 'exosome' 3->5 exoribonuclease complex is required for the 3' processing of the 7s pre-rRNA to the mature 5. 8s rRNA.; Remark: alternate name for S. cerevisiae Rrp42: YDL111c.; Similarity: S. cerevisiae Rrp42p is related to RNase PH.; Title: similarity to 3-5 exoribonuclease involved in rRNA processing Rrp42 - Saccharomyces cerevisiae; nucleus; See PMID 9390555; See PMID 10465791; uncharacterized protein 2054336 4986218 An12g08670 Aspergillus niger uncharacterized protein XP_059601937.1 2053125 D 5061 CDS An12g08680 4986219 join(2054688..2054720,2054771..2054812,2054886..2055299) III 1 NT_166527.1 Catalytic activity: Peptidylproline (omega=180) <=> peptidylproline (omega=0).; Similarity: cyp-4 from C. elegans belongs to the cyclophilin-type peptidylprolyl isomerasease family.; Title: strong similarity to cyclophilin isoform 4 cyp-4 - Caenorhabditis elegans; See PMID 8694762; uncharacterized protein 2055299 4986219 An12g08680 Aspergillus niger uncharacterized protein XP_001395919.1 2054688 D 5061 CDS An12g08690 4986220 join(2056464..2056537,2056592..2056710,2056771..2057784,2057973..2058307) III 1 NT_166527.1 Function: S. cerevisiae Mrs6 (geranylgeranyl transferase component A) binds to unprenylated Rab (G-protein), presents it to the catalytic component B (Bet2), and remains bound to it after the geranylgeranyl transfer reaction. Mrs6 (component A) may be regenerated by transferring its prenylated Rab to a protein acceptor.; Remark: alternate names for S. cerevisiae Mrs6: YOR370C, MSI4.; Title: strong similarity to Rab geranylgeranyl transferase component A Mrs6 - Saccharomyces cerevisiae; See PMID 8183917; See PMID 7882424; See PMID 8132658; uncharacterized protein 2058307 4986220 An12g08690 Aspergillus niger uncharacterized protein XP_001395920.1 2056464 D 5061 CDS An12g08700 84592690 join(2059204..2059557,2059696..2059864,2059914..2060499,2060567..2060954) III 1 NT_166527.1 hypothetical protein 2060954 84592690 An12g08700 Aspergillus niger hypothetical protein XP_059601938.1 2059204 D 5061 CDS An12g08710 84592691 join(2063045..2063126,2063165..2063265,2063480..2063674,2063783..2063926,2064009..2064068,2064286..2064475,2064590..2064693,2064784..2064873,2064972..2065020,2065163..2065211,2065417..2065527,2065623..2065941) III 1 NT_166527.1 hypothetical protein 2065941 84592691 An12g08710 Aspergillus niger hypothetical protein XP_059601939.1 2063045 D 5061 CDS An12g08720 4986223 2066896..2068461 III 1 NT_166527.1 Title: similarity to hypothetical protein AAG27909.1 - Arabidopsis thaliana; uncharacterized protein 2068461 4986223 An12g08720 Aspergillus niger uncharacterized protein XP_001395923.3 2066896 D 5061 CDS An12g08730 4986224 join(2072731..2072976,2073161..2073295,2073376..2073650,2073823..2073865) III 1 NT_166527.1 Function: the S. cerevisiae Mcm1 protein is a DNA-binding transcription factor involved in transcriptional regulation of several different target genes. For example it interacts with the alpha-2 repressor or with the alpha-1 activator thereby regulating the expression of mating-type-specific genes.; Remark: alternate names for S. cerevisiae Mcm1: Fun80, YMR043W.; Title: similarity to MADS-box domain transcription factor Mcm1 - Saccharomyces cerevisiae; nucleus; See PMID 9490409; See PMID 3066908; uncharacterized protein 2073865 4986224 An12g08730 Aspergillus niger uncharacterized protein XP_059601940.1 2072731 D 5061 CDS An12g08740 84592692 complement(join(2074338..2074536,2074651..2074709,2074839..2074859)) III 1 NT_166527.1 hypothetical protein 2074859 84592692 An12g08740 Aspergillus niger hypothetical protein XP_059601941.1 2074338 R 5061 CDS An12g08750 4986226 complement(join(2075453..2076924,2077012..2077123)) III 1 NT_166527.1 Title: similarity to hypothetical protein At2g21120 - Arabidopsis thaliana; uncharacterized protein 2077123 4986226 An12g08750 Aspergillus niger uncharacterized protein XP_059601942.1 2075453 R 5061 CDS An12g08760 4986227 join(2078046..2078078,2078157..2078668,2078740..2078890) III 1 NT_166527.1 Complex: N. crassa Vma-4 belongs to the v-ATPase an heteromultimeric enzyme composed of a peripheral catalytic v1 complex (components A to H) attached to an integral membrane v0 proton pore complex (components: A, C, C', C'' and D).; Function: N. crassa Vma-4 is a subunit of the peripheral v1 complex of vacuolar ATPase (v-ATPase). The V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to vacuolar ATPase subunit E Vma-4 - Neurospora crassa; vacuole; See PMID 10340846; See PMID 7619848; uncharacterized protein 2078890 4986227 An12g08760 Aspergillus niger uncharacterized protein XP_001395927.1 2078046 D 5061 CDS An12g08770 4986228 complement(join(2079648..2080286,2080335..2080488,2080540..2080618,2080671..2080800,2080857..2080909,2080959..2081060,2081113..2082151)) III 1 NT_166527.1 hypothetical protein 2082151 4986228 An12g08770 Aspergillus niger hypothetical protein XP_001395928.1 2079648 R 5061 CDS An12g08780 84592693 join(2082869..2083029,2083063..2083096) III 1 NT_166527.1 hypothetical protein 2083096 84592693 An12g08780 Aspergillus niger hypothetical protein XP_059601943.1 2082869 D 5061 CDS An12g08790 4986230 join(2085449..2085928,2085989..2088925,2088978..2089207,2089255..2090170) III 1 NT_166527.1 Function: the human FIC1 protein encodes putative integral membrane P-type ATPase and potential aminophospholipid translocase (or flippase). It may play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids in the canicular membrane. It may have a role in transport of bile acids into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both.; Remark: defects in FIC1 also are the cause of benign recurrent intrahepatic cholestasis (bric or summerskill syndrome), an autosomal recessive disorder, characterized by intermittent episodes of cholestasis without extrahepatic bile duct obstruction, with initial elevation of serum bile acids, followed by cholestatic jaundice which generally spontaneously resolves after periods of weeks to months.; Remark: defects in FIC1 are the cause of progressive familial intrahepatic cholestasis type 1 (pfic1 or byler disease), an autosomal recessive disorder, characterized by early infancy cholestasis, that may be initially episodic but progresses to malnutrition, growth retardation and end-stage liver disease before adulthood.; Remark: defects in fic1 could be associated with recurrent intrahepatic cholestasis of pregnancy (icp or ricp pregnancy-related cholestasis), characterized by generalized itching, with or without jaundice, absence of biliary colic, absence of jaundice or pruritus between pregnancies, and absence of chronic liver disease. appears during pregnancy (primarily in the third trimester), and disappears shortly postpartum. may be a female-limited autosomal dominant inheritance.; Title: strong similarity to P-type ATPase FIC1 -Homo sapiens; See PMID 9500542; uncharacterized protein 2090170 4986230 An12g08790 Aspergillus niger uncharacterized protein XP_059601944.1 2085449 D 5061 CDS An12g08800 4986231 join(2091343..2091365,2091435..2097561,2097613..2097708,2097770..2097874) III 1 NT_166527.1 Function: S. cerevisiae Sen1 is required for endonucleolytic cleavage of introns from all families of precursor tRNAs. Sen1 is also involved in processing of rRNAs and small nuclear and nucleolar RNAs.; Remark: alternate names for S. cerevisiae Sen1: YLR430w, Cik3, Nrd2.; Similarity: S. cerevisiae Sen1 belongs to the Dna2/Nam7 helicase family.; Title: strong similarity to ATP dependent RNA helicase Sen1 - Saccharomyces cerevisiae; nucleus; See PMID 9365256; See PMID 9819377; See PMID 1569945; uncharacterized protein 2097874 4986231 An12g08800 Aspergillus niger uncharacterized protein XP_001395931.1 2091343 D 5061 CDS An12g08810 84592694 complement(join(2100752..2100947,2101023..2101110,2101224..2101286,2101393..2101573)) III 1 NT_166527.1 hypothetical protein 2101573 84592694 An12g08810 Aspergillus niger hypothetical protein XP_059601945.1 2100752 R 5061 CDS An12g08820 4986233 2102731..>2104341 III 1 NT_166527.1 Remark: C-terminally truncated ORF due to the end of contig.; Title: weak similarity to for serine/threonine protein kinase NPKCSD - Suberites domuncula [truncated ORF]; uncharacterized protein 2104341 4986233 An12g08820 Aspergillus niger uncharacterized protein XP_059601946.1 2102731 D 5061 CDS An12g08830 4986234 join(2104992..2105024,2105115..2105831) III 1 NT_166527.1 Title: weak similarity to outer arm dynein light chain LC7 - Chlamydomonas reinhardtii; See PMID 10402468; uncharacterized protein 2105831 4986234 An12g08830 Aspergillus niger uncharacterized protein XP_001395934.1 2104992 D 5061 CDS An12g08840 84592695 complement(join(2106290..2106405,2106487..2106577,2106679..2106753,2106852..2107026,2107363..2107579,2107693..2107803,2107854..2108159,2108279..2108619,2108755..2108843)) III 1 NT_166527.1 hypothetical protein 2108843 84592695 An12g08840 Aspergillus niger hypothetical protein XP_059601947.1 2106290 R 5061 CDS An12g08850 84592696 join(2109234..2109440,2109496..2109624) III 1 NT_166527.1 hypothetical protein 2109624 84592696 An12g08850 Aspergillus niger hypothetical protein XP_059601948.1 2109234 D 5061 CDS An12g08860 84592697 join(2110464..2110489,2110593..2110725) III 1 NT_166527.1 hypothetical protein 2110725 84592697 An12g08860 Aspergillus niger hypothetical protein XP_059601949.1 2110464 D 5061 CDS An12g08870 84592698 join(2111169..2111304,2111345..2111445) III 1 NT_166527.1 hypothetical protein 2111445 84592698 An12g08870 Aspergillus niger hypothetical protein XP_059601950.1 2111169 D 5061 CDS An12g08880 84592699 complement(join(2112455..2112601,2112692..2112794,2112852..2112935,2113035..2113192,2113306..2113341)) III 1 NT_166527.1 hypothetical protein 2113341 84592699 An12g08880 Aspergillus niger hypothetical protein XP_059601951.1 2112455 R 5061 CDS An12g08890 4986240 complement(join(2113795..2113935,2114068..2114859)) III 1 NT_166527.1 Title: similarity to hypothetical protein EAA72664.1 - Gibberella zeae; uncharacterized protein 2114859 4986240 An12g08890 Aspergillus niger uncharacterized protein XP_059601952.1 2113795 R 5061 CDS An12g08900 4986241 complement(join(2115980..2117697,2117764..2118175)) III 1 NT_166527.1 Remark: also similarity to Trypanosoma cruzi cyclin 4 (cyc4).; Title: similarity to hypothetical Pcl-like cyclin pas1p - Schizosaccharomyces pombe; uncharacterized protein 2118175 4986241 An12g08900 Aspergillus niger uncharacterized protein XP_001395941.1 2115980 R 5061 CDS An12g08910 84592700 join(2118253..2118320,2118538..2118714,2118801..2118883,2118927..2119098,2119184..2119441,2119515..2119674,2119718..2119771) III 1 NT_166527.1 hypothetical protein 2119771 84592700 An12g08910 Aspergillus niger hypothetical protein XP_059601953.1 2118253 D 5061 CDS An12g08915 84592701 complement(join(2120353..2120424,2120475..2120566,2120919..2120928)) III 1 NT_166527.1 hypothetical protein 2120928 84592701 An12g08915 Aspergillus niger hypothetical protein XP_059601954.1 2120353 R 5061 CDS An12g08920 84592702 complement(join(2121575..2121710,2122007..2122127,2122168..2122483)) III 1 NT_166527.1 hypothetical protein 2122483 84592702 An12g08920 Aspergillus niger hypothetical protein XP_059601955.1 2121575 R 5061 CDS An12g08930 4986245 complement(join(2123577..2123666,2123714..2123869,2123924..2124044,2124090..2124276,2124332..2124613,2124664..2124797,2124844..2125061)) III 1 NT_166527.1 Catalytic activity: an epoxide + H2O = a glycol.; Function: hyl1 of A. niger hydrolyses 4-nitrostyrene epoxide and other epoxides.; Pathway: tetrachloroethene degradation; Remark: also strong similarity to Aspergillus niger epoxide hydrolase protein sequence SEQ ID NO:2 patent WO200068394-A1.; Remark: epoxide hydrolases have important roles in the defense of cells against potentially harmful epoxides. Conversion of epoxides into less toxic and more easily excreted diols is a universally successful strategy.; Remark: the sequence variantion might be sequence errors or strain variation.; Title: strong similarity to epoxide hydrolase hyl1 -Aspergillus niger; See PMID 10548561; See PMID 10673439; uncharacterized protein 2125061 4986245 An12g08930 Aspergillus niger uncharacterized protein XP_001395945.1 2123577 R 5061 CDS An12g08940 4986246 complement(join(2125511..2125566,2125613..2126120,2126166..2126243,2126291..2126611,2126656..2126785,2126831..2126864,2126924..2126999)) III 1 NT_166527.1 Remark: strong similarity to E. coli bioS1 protein patent DE19806872-A1.; Similarity: to nifS proteins.; Title: strong similarity to biotin biosynthesis gene bioS1 from patent DE19806872-A1 - Escherichia coli; uncharacterized protein 2126999 4986246 An12g08940 Aspergillus niger uncharacterized protein XP_001395946.1 2125511 R 5061 CDS An12g08950 4986247 join(2127384..2127614,2127763..2128024,2128078..2128712,2128757..2129581) III 1 NT_166527.1 Remark: the allantoin permease component encoded by DAL4 in S. cerevisiae has similarity to the uracil permease component encoded by FUR4.; Title: strong similarity to allantoin transport protein Dal4 - Saccharomyces cerevisiae; See PMID 1293888; See PMID 11409177; uncharacterized protein 2129581 4986247 An12g08950 Aspergillus niger uncharacterized protein XP_001395947.3 2127384 D 5061 CDS An12g08960 4986248 complement(join(2131258..2133448,2133542..2133990)) III 1 NT_166527.1 Function: major nitrogen regulatory protein. positively acting regulatory gene of nitrogen metabolite repression.; Gene-ID: areA; Mapping: areA from A. niger is mapped to chromosome III (LG III); see list from DSM, PUBMED 11589576.; Remark: northern analysis indicates the synthesis of multiple transcripts, the major species being approximately 2. 95 kb and 3. 1 kb. Maximal expression of areAnig is observed under conditions of nitrogen starvation and is mainly due to an increase in the level of the shorter transcript.; Remark: putative sequencing error at position 41647,generating a stop codon.; Remark: the differences in the sequence are caused by strain variations or sequencing errors.; Similarity: to other fungal nitrogen regulatory proteins. To gata transcription factors in the zinc-finger region.; nucleus; putative sequencing error; See PMID 9540832; See PMID 11589576; regulator of nitrogen metabolite repression areA-Aspergillus niger [putative sequencing error] 2133990 areA 4986248 areA Aspergillus niger regulator of nitrogen metabolite repression areA-Aspergillus niger [putative sequencing error] XP_059604544.1 2131258 R 5061 CDS An12g08970 84592703 join(2134473..2134555,2134651..2134662,2135067..2135149,2135251..2135327,2135532..2135573) III 1 NT_166527.1 Remark: the ORF encoded protein shows similarities to the upstream region of the areA gene from Aspergillus niger.; hypothetical protein 2135573 84592703 An12g08970 Aspergillus niger hypothetical protein XP_059604545.1 2134473 D 5061 CDS An12g08980 84592704 complement(join(2136052..2136153,2136346..2136399,2136491..2136964,2137005..2137214)) III 1 NT_166527.1 hypothetical protein 2137214 84592704 An12g08980 Aspergillus niger hypothetical protein XP_059604546.1 2136052 R 5061 CDS An12g08990 84592705 join(2137706..2138087,2138488..2138651) III 1 NT_166527.1 hypothetical protein 2138651 84592705 An12g08990 Aspergillus niger hypothetical protein XP_059604547.1 2137706 D 5061 CDS An12g09000 84592706 complement(join(2139459..2139703,2139771..2139855,2140194..2140323,2140444..2140691,2140775..2140915,2141019..2141081,2141165..2141278,2141328..2141449,2141501..2141557,2141705..2141804)) III 1 NT_166527.1 hypothetical protein 2141804 84592706 An12g09000 Aspergillus niger hypothetical protein XP_059604548.1 2139459 R 5061 CDS An12g09010 84592707 join(2141965..2142174,2142314..2142673,2142757..2142775,2142849..2142956,2143004..2143227) III 1 NT_166527.1 hypothetical protein 2143227 84592707 An12g09010 Aspergillus niger hypothetical protein XP_059604549.1 2141965 D 5061 CDS An12g09020 4986254 complement(join(2143929..2144578,2144645..2144974,2145030..2145096)) III 1 NT_166527.1 Remark: the similarity is restricted only to the N-terminus.; Title: similarity to hypothetical protein CAD79668.1 - Neurospora crassa; uncharacterized protein 2145096 4986254 An12g09020 Aspergillus niger uncharacterized protein XP_059604550.1 2143929 R 5061 CDS An12g09030 84592708 join(2145384..2145467,2145741..2145766,2145836..2145867,2145932..2145983,2146119..2146146,2146338..2146391) III 1 NT_166527.1 hypothetical protein 2146391 84592708 An12g09030 Aspergillus niger hypothetical protein XP_059604551.1 2145384 D 5061 CDS An12g09040 84592709 join(2146728..2146750,2146900..2146978,2147135..2147214,2147296..2147358,2147496..2147600,2147882..2147980,2148287..2148437,2148533..2148604) III 1 NT_166527.1 hypothetical protein 2148604 84592709 An12g09040 Aspergillus niger hypothetical protein XP_059604552.1 2146728 D 5061 CDS An12g09050 84592710 complement(join(2148771..2148807,2149012..2149154,2149399..2149488,2149760..2149780)) III 1 NT_166527.1 Title: questionable ORF; uncharacterized protein 2149780 84592710 An12g09050 Aspergillus niger uncharacterized protein XP_059604553.1 2148771 R 5061 CDS An12g09060 84592711 join(2150411..2150425,2150541..2150626,2150782..2150849,2151025..2151215) III 1 NT_166527.1 hypothetical protein 2151215 84592711 An12g09060 Aspergillus niger hypothetical protein XP_059604554.1 2150411 D 5061 CDS An12g09070 84592712 join(2151577..2151607,2151639..2151923,2152017..2152168,2152364..2152444,2152558..2152792,2153280..2153350) III 1 NT_166527.1 hypothetical protein 2153350 84592712 An12g09070 Aspergillus niger hypothetical protein XP_059604555.1 2151577 D 5061 CDS An12g09080 84592713 complement(join(2153558..2153624,2153702..2153800,2153877..2154135,2154298..2154373,2154444..2154518)) III 1 NT_166527.1 Title: similarity to EST an_3065 - Aspergillus niger; uncharacterized protein 2154518 84592713 An12g09080 Aspergillus niger uncharacterized protein XP_059604556.1 2153558 R 5061 CDS An12g09090 84592714 complement(2155609..2155926) III 1 NT_166527.1 Title: similarity to hypothetical protein encoded by An08g08730 - Aspergillus niger; uncharacterized protein 2155926 84592714 An12g09090 Aspergillus niger uncharacterized protein XP_059604557.1 2155609 R 5061 CDS An12g09100 84592715 join(2156328..2156352,2156427..2156523,2156886..2157196,2157317..2157422,2157602..2157772,2157893..2158085,2158136..2158276) III 1 NT_166527.1 hypothetical protein 2158276 84592715 An12g09100 Aspergillus niger hypothetical protein XP_059604558.1 2156328 D 5061 CDS An12g09110 84592716 join(2158716..2158729,2158825..2158997,2159081..2159173,2159244..2159410) III 1 NT_166527.1 hypothetical protein 2159410 84592716 An12g09110 Aspergillus niger hypothetical protein XP_059604559.1 2158716 D 5061 CDS An12g09120 4986264 complement(join(2160754..2163543,2163604..2163825)) III 1 NT_166527.1 Title: strong similarity to hypothetical protein EAA47516.1 - Magnaporthe grisea; uncharacterized protein 2163825 4986264 An12g09120 Aspergillus niger uncharacterized protein XP_001395964.1 2160754 R 5061 CDS An12g09130 4986265 complement(join(2164592..2165055,2165118..2165165,2165215..2165285,2165353..2165454,2165520..2165794,2165959..2165970)) III 1 NT_166527.1 Remark: similarity to maize ZmGnsN3 glucanase of patent WO200073470-A2 found in TREMBL:AX053132_1.; Remark: the predicted ORF is approximately N-terminal 60 amino acids longer.; Title: similarity to glucanase ZmGnsN3 from patent WO200073470-A2 - Zea mays; uncharacterized protein 2165970 4986265 An12g09130 Aspergillus niger uncharacterized protein XP_059604560.1 2164592 R 5061 CDS An12g09140 4986266 join(2168338..2168476,2168556..2168806,2168864..2168897,2168952..2169858,2169912..2170050) III 1 NT_166527.1 Remark: alternative name is YGR065c.; Remark: expression of YGR065C S. cerevisiae under the control of the constitutive ADH1 promoter resulted in very high biotin transport rates across the plasma membrane that were no longer regulated by the biotin concentration in the growth medium.; Similarity: belongs to the major facilitator superfamily (MFS).; Title: strong similarity to H+-biotin symporter Vht1 - Saccharomyces cerevisiae; See PMID 10373489; uncharacterized protein 2170050 4986266 An12g09140 Aspergillus niger uncharacterized protein XP_001395966.1 2168338 D 5061 CDS An12g09150 4986267 join(2170420..2170524,2170580..2170768,2170815..2171062,2171131..2172046) III 1 NT_166527.1 Remark: strong similarity to Corynebacterium glutamicum sequence 419 from Patent WO0100842-A/419.; Similarity: belongs to the nitrilotriacetate monooxygenases.; Title: strong similarity to sequence 419 from patent WO0100842-A - Corynebacterium glutamicum; uncharacterized protein 2172046 4986267 An12g09150 Aspergillus niger uncharacterized protein XP_001395967.1 2170420 D 5061 CDS An12g09160 84592717 join(2172251..2172299,2172480..2172596,2172657..2172669,2172755..2172829,2173042..2173105,2173158..2173238) III 1 NT_166527.1 hypothetical protein 2173238 84592717 An12g09160 Aspergillus niger hypothetical protein XP_059604561.1 2172251 D 5061 CDS An12g09170 84592718 <2173592..2174050 III 1 NT_166527.1 Remark: N-terminal truncated ORF due to end of contig.; hypothetical protein [truncated ORF] 2174050 84592718 An12g09170 Aspergillus niger hypothetical protein [truncated ORF] XP_059601956.1 2173592 D 5061 CDS An12g09180 4986270 complement(join(2174284..2174676,2174821..2174898,2174959..2175459)) III 1 NT_166527.1 hypothetical protein 2175459 4986270 An12g09180 Aspergillus niger hypothetical protein XP_059601957.1 2174284 R 5061 CDS An12g09190 4986271 complement(join(2175992..2176102,2176160..2177287)) III 1 NT_166527.1 Remark: similarity to human nucleic acid-binding protein, NuABP-10 patent WO200044900-A2.; Remark: the predicted ORF represents an putative zinc-finger protein.; Title: similarity to nucleic acid-binding protein NuABP-10 from patent WO200044900-A2 - Homo sapiens; uncharacterized protein 2177287 4986271 An12g09190 Aspergillus niger uncharacterized protein XP_001395971.3 2175992 R 5061 CDS An12g09200 84592719 join(2178137..2178142,2178233..2178298,2178383..2178475) III 1 NT_166527.1 hypothetical protein 2178475 84592719 An12g09200 Aspergillus niger hypothetical protein XP_059601958.1 2178137 D 5061 CDS An12g09210 84592720 join(2179097..2179101,2179181..2179361,2179462..2179575,2179690..2180073) III 1 NT_166527.1 hypothetical protein 2180073 84592720 An12g09210 Aspergillus niger hypothetical protein XP_059601959.1 2179097 D 5061 CDS An12g09220 84592721 complement(join(2180466..2180734,2180871..2181010,2181165..2181394)) III 1 NT_166527.1 hypothetical protein 2181394 84592721 An12g09220 Aspergillus niger hypothetical protein XP_059601960.1 2180466 R 5061 CDS An12g09230 84592722 complement(join(2181633..2181768,2181809..2182027,2182125..2182219)) III 1 NT_166527.1 hypothetical protein 2182219 84592722 An12g09230 Aspergillus niger hypothetical protein XP_059601961.1 2181633 R 5061 CDS An12g09240 84592723 complement(join(2182250..2182365,2182439..2182521,2182602..2182758,2182809..2182884)) III 1 NT_166527.1 hypothetical protein 2182884 84592723 An12g09240 Aspergillus niger hypothetical protein XP_059601962.1 2182250 R 5061 CDS An12g09250 84592724 join(2182995..2183150,2183246..2183362) III 1 NT_166527.1 hypothetical protein 2183362 84592724 An12g09250 Aspergillus niger hypothetical protein XP_059601963.1 2182995 D 5061 CDS An12g09260 4986278 join(2184839..2184982,2185061..2185287,2185354..2185588,2185658..2185771,2185842..2186270) III 1 NT_166527.1 Title: strong similarity to hypothetical protein CAF06101.1 - Neurospora crassa; uncharacterized protein 2186270 4986278 An12g09260 Aspergillus niger uncharacterized protein XP_001395978.1 2184839 D 5061 CDS An12g09270 4986279 complement(join(2186495..2186740,2186807..2187234,2187309..2187531,2187629..2187978,2188055..2188268,2188324..2188470)) III 1 NT_166527.1 Function: Lac12 from K. lactis mediates the transport of lactose and it would appear that the permease works in part by a proton symport mechanism.; Title: strong similarity to lactose permease Lac12 -Kluyveromyces lactis; See PMID 3053697; uncharacterized protein 2188470 4986279 An12g09270 Aspergillus niger uncharacterized protein XP_001395979.1 2186495 R 5061 CDS An12g09280 4986280 complement(join(2189207..2189334,2189622..2190015)) III 1 NT_166527.1 Title: similarity to hypothetical protein encoded by An01g02930 - Aspergillus niger; uncharacterized protein 2190015 4986280 An12g09280 Aspergillus niger uncharacterized protein XP_001395980.3 2189207 R 5061 CDS An12g09290 84592725 join(2190945..2191036,2191117..2191182,2191318..2191391,2191445..2191662) III 1 NT_166527.1 hypothetical protein 2191662 84592725 An12g09290 Aspergillus niger hypothetical protein XP_059601964.1 2190945 D 5061 CDS An12g09300 4986282 join(2191866..2191981,2192088..2192365,2192421..2192460,2192517..2192592) III 1 NT_166527.1 hypothetical protein 2192592 4986282 An12g09300 Aspergillus niger hypothetical protein XP_059601965.1 2191866 D 5061 CDS An12g09310 4986283 join(2193178..2193283,2193333..2193705,2193751..2195341) III 1 NT_166527.1 Function: Bacillus subtilis PNB carboxy-esterase (PNBCE) catalyzes hydrolysis of several beta-lactam antibiotic PNB esters to the corresponding free acid and PNB alcohol.; Remark: p-Nitrobenzyl esters serve as protecting groups on intermediates in the manufacture of clinically important oral beta-lactam antibiotics; de-esterification of the intermediates is required for synthesis of the final product.; Similarity: belongs to the carboxylesterases type B.; Title: similarity to para-nitrobenzyl esterase pnbA - Bacillus subtilis; See PMID 7828905; uncharacterized protein 2195341 4986283 An12g09310 Aspergillus niger uncharacterized protein XP_001395983.1 2193178 D 5061 CDS An12g09320 84592726 join(2195803..2195856,2195965..2196141,2196188..2196285,2196394..2196477,2196554..2196840,2196912..2196980,2197084..2197270,2197358..2197442) III 1 NT_166527.1 hypothetical protein 2197442 84592726 An12g09320 Aspergillus niger hypothetical protein XP_059601966.1 2195803 D 5061 CDS An12g09330 4986285 complement(2197910..2198683) III 1 NT_166527.1 Remark: in yeast PAD (phenylacrylic acid decarboxylase) activity and CA (cinnamic acid) resistance,but not steady-state PAD1 mRNA levels, are influenced by mitochondrial genotype. PAD1 is a single-copy gene in the yeast genome and not essential for viability.; Title: strong similarity to phenylacrylic acid decarboxylase Pad1 - Saccharomyces cerevisiae; See PMID 8181743; uncharacterized protein 2198683 4986285 An12g09330 Aspergillus niger uncharacterized protein XP_001395985.1 2197910 R 5061 CDS An12g09340 4986286 2199245..2200849 III 1 NT_166527.1 Remark: strong similarity to S. cerevisiae ferulic acid decarboxylasepatent EP857789-A2.; Remark: the S. cerevisiae enzyme is able to transform ferulic acid and p-coumaric acid to 4-vinylguaiacol and 4-vinylphenol, respectively, by nonoxidative decarboxylation.; Title: strong similarity to ferulic acid decarboxylase FDC1 from patent EP857789-A2 - Saccharomyces cerevisiae; uncharacterized protein 2200849 4986286 An12g09340 Aspergillus niger uncharacterized protein XP_001395986.1 2199245 D 5061 CDS An12g09350 4986287 join(2201181..2201974,2202227..2202407) III 1 NT_166527.1 Title: similarity to hypothetical protein PaxU -Penicillium paxilli; uncharacterized protein 2202407 4986287 An12g09350 Aspergillus niger uncharacterized protein XP_001395987.3 2201181 D 5061 CDS An12g09360 84592727 join(2202552..2202756,2202846..2203115,2203210..2203350,2203442..2203529,2203625..2203666,2203743..2203971) III 1 NT_166527.1 hypothetical protein 2203971 84592727 An12g09360 Aspergillus niger hypothetical protein XP_059601967.1 2202552 D 5061 CDS An12g09370 4986289 join(2204104..2204463,2204523..2205809) III 1 NT_166527.1 Remark: alternativ name is YDR497c.; Remark: gene disruption and tetrad analysis showed that yeast cells contain two separate myoinositol transporters. The ITR1 product was the major transporter and the ITR2 product the minor one in cells grown in minimum medium containing glucose. Northern blot analysis showed that ITR1 mRNA was much more abundant than ITR2 mRNA.; Title: strong similarity to myo-inositol permease Itr1 - Saccharomyces cerevisiae; See PMID 2040626; uncharacterized protein 2205809 4986289 An12g09370 Aspergillus niger uncharacterized protein XP_001395989.1 2204104 D 5061 CDS An12g09380 84592728 complement(join(2206081..2206134,2206227..2206303,2206402..2206544,2206618..2206692,2207094..2207196,2207470..2207532,2207692..2207749,2207835..2208044,2208080..2208154)) III 1 NT_166527.1 hypothetical protein 2208154 84592728 An12g09380 Aspergillus niger hypothetical protein XP_059601968.1 2206081 R 5061 CDS An12g09390 84592729 join(2208778..2208963,2209081..2209461) III 1 NT_166527.1 hypothetical protein 2209461 84592729 An12g09390 Aspergillus niger hypothetical protein XP_059601969.1 2208778 D 5061 CDS An12g09400 84592730 join(2210209..2210337,2210415..2210801) III 1 NT_166527.1 hypothetical protein 2210801 84592730 An12g09400 Aspergillus niger hypothetical protein XP_059601970.1 2210209 D 5061 CDS An12g09410 84592731 complement(join(2211142..2211556,2211736..2211872)) III 1 NT_166527.1 hypothetical protein 2211872 84592731 An12g09410 Aspergillus niger hypothetical protein XP_059601971.1 2211142 R 5061 CDS An12g09420 84592732 join(2212798..2212947,2213057..2213152,2213227..2213341,2213458..2213536,2213674..2213722) III 1 NT_166527.1 hypothetical protein 2213722 84592732 An12g09420 Aspergillus niger hypothetical protein XP_059601972.1 2212798 D 5061 CDS An12g09430 84592733 join(2215502..2215549,2215723..2215951,2216015..2216091,2216145..2216603) III 1 NT_166527.1 hypothetical protein 2216603 84592733 An12g09430 Aspergillus niger hypothetical protein XP_059601973.1 2215502 D 5061 CDS An12g09440 4986296 complement(join(2217233..2217389,2217453..2217758,2217815..2218301,2218351..2218605,2218916..2218979,2219345..2219401,2219516..2219707)) III 1 NT_166527.1 Title: similarity to hypothetical protein PA1213 -Pseudomonas aeruginosa; uncharacterized protein 2219707 4986296 An12g09440 Aspergillus niger uncharacterized protein XP_001395996.3 2217233 R 5061 CDS An12g09450 4986297 join(2220866..2221486,2221618..2222283) III 1 NT_166527.1 Remark: a heterologous gene encoding a gene product which confers trichothecene resistance can be used to transform plant cells to make them resistant to fungal infection.; Remark: similarity to yeast sequence encoding trichothecene resistance polypeptide patent WO200060061-A2.; Title: similarity to trichothecene resistance polypeptide from patent WO200060061-A2 - Saccharomyces cerevisiae; uncharacterized protein 2222283 4986297 An12g09450 Aspergillus niger uncharacterized protein XP_059601974.1 2220866 D 5061 CDS An12g09460 4986298 complement(join(2222444..2222870,2222930..2223165,2223224..2223658,2223741..2224036,2224118..2224137,2224222..2224515,2224569..2224607,2224743..2224766,2224833..2225056)) III 1 NT_166527.1 Remark: similarity to A. terreus ORF13 Zinc finger II protein patent WO200037629-A2.; Remark: the homologue regulatory protein is a member of the Aspergillus terreus lovastatin biosynthesis gene cluster.; Similarity: belongs to the unassigned GAL4-type zinc cluster proteins.; Title: similarity to ORF13 Zinc finger II protein from patent WO200037629-A2 - Aspergillus terreus; uncharacterized protein 2225056 4986298 An12g09460 Aspergillus niger uncharacterized protein XP_001395998.3 2222444 R 5061 CDS An12g09470 4986299 join(2225489..2225805,2225870..2225918,2225979..2226099,2226147..2226280) III 1 NT_166527.1 Remark: Cofilin and related proteins isolated from diverse organisms are low molecular weight proteins (15-20 kD) that possess several activities in vitro. All bind to monomeric actin and sever filaments, and some can stably associate with filaments.; Remark: Cofilin from S. cerevisiae binds to and severs actin filaments in vitro, and also enhances their depolymerization.; Remark: alternate name is YLL050c .; Title: similarity to cofilin Cof1 - Saccharomyces cerevisiae; See PMID 10231390; See PMID 8421056; See PMID 8440472; uncharacterized protein 2226280 4986299 An12g09470 Aspergillus niger uncharacterized protein XP_001395999.3 2225489 D 5061 CDS An12g09480 4986300 complement(join(2226469..2226712,2226769..2227196,2227251..2227374,2227422..2227590,2227640..2227741,2227792..2227846)) III 1 NT_166527.1 Function: M. sativa F3H is involved in the synthesis of flavonoids.; Title: similarity to naringenin 3-dioxygenase F3H -Medicago sativa; See PMID 8541503; uncharacterized protein 2227846 4986300 An12g09480 Aspergillus niger uncharacterized protein XP_001396000.1 2226469 R 5061 CDS An12g09490 4986301 join(2228350..2228545,2228595..2228612,2228660..2228810,2228860..2229011,2229064..2229439,2229494..2229736,2229795..2229921) III 1 NT_166527.1 Function: S. cerevisiae VHT1 is a plasma membrane H+-biotin symporter.; Remark: the systematic name for S. cerevisiae VHT1 is YGR065. C; Title: strong similarity to H+-biotin symporter Vht1 - Saccharomyces cerevisiae; plasma membrane; See PMID 10373489; uncharacterized protein 2229921 4986301 An12g09490 Aspergillus niger uncharacterized protein XP_001396001.1 2228350 D 5061 CDS An12g09500 4986302 complement(2230433..2232586) III 1 NT_166527.1 Function: human ankyrin-1 provides the primary linkage between the membrane skeleton and integral plasma membrane proteins.; Title: similarity to ankyrin ANK1 - Homo sapiens; cytoskeleton; See PMID 10810176; uncharacterized protein 2232586 4986302 An12g09500 Aspergillus niger uncharacterized protein XP_001396002.1 2230433 R 5061 CDS An12g09510 4986303 join(<2234210..2234406,2234491..2235655) III 1 NT_166527.1 Catalytic activity: Hg + NADP(+) + H(+) = Hg(2+) + NADPH.; Remark: Microbes can detoxify organo-mercurials and mercury salts through sequential action of two enzymes,organomercury lyase and mercuric ion reductase (MerA).; Remark: N-terminally truncated due to contig border.; Similarity: MerA from Bacillus sp. strain RC607 shows homology to FAD-dependent disulphide oxidoreductases and to dihydrolipoamide dehydrogenases.; Title: similarity to mercury(II) reductase merA -Bacillus sp. [truncated ORF]; See PMID 2067577; See PMID 2536669; uncharacterized protein 2235655 4986303 An12g09510 Aspergillus niger uncharacterized protein XP_001396003.3 2234210 D 5061 CDS An12g09520 4986304 2236164..2237105 III 1 NT_166527.1 Title: weak similarity to hypothetical protein encoded by An02g13400 - Aspergillus niger; uncharacterized protein 2237105 4986304 An12g09520 Aspergillus niger uncharacterized protein XP_001396004.1 2236164 D 5061 CDS An12g09530 4986305 complement(2237233..2237781) III 1 NT_166527.1 hypothetical protein 2237781 4986305 An12g09530 Aspergillus niger hypothetical protein XP_001396005.1 2237233 R 5061 CDS An12g09540 84592734 2238849..2239940 III 1 NT_166527.1 Title: strong similarity to hypothetical yellow-related protein DR1790 - Deinococcus radiodurans; uncharacterized protein 2239940 84592734 An12g09540 Aspergillus niger uncharacterized protein XP_059606969.1 2238849 D 5061 CDS An12g09550 84592735 join(2240340..2240432,2240496..2240557,2240736..2241399) III 1 NT_166527.1 Title: weak similarity to hypothetical poly(A) binding protein II PABPII - Xenopus laevis; uncharacterized protein 2241399 84592735 An12g09550 Aspergillus niger uncharacterized protein XP_059606970.1 2240340 D 5061 CDS An12g09560 4986308 join(2243392..2243454,2243520..2244632,2244705..2244871,2244935..2245088) III 1 NT_166527.1 Function: AvnA is involved in the conversion of averantin to averufin in aflatoxin biosynthesis in Aspergillus parasiticus.; Remark: Aflatoxins are synthesized by condensation of acetate units.; Remark: Aflatoxins are toxic and carcinogenic secondary metabolites produced by the fungi Aspergillus flavus and A. parasiticus.; Similarity: The avnA gene encodes a cytochrome P-450-type monooxygenase that has been assigned to a new P-450 gene family named CYP60A1.; Title: strong similarity to cytochrome P450 monooxygenase avnA - Aspergillus parasiticus; See PMID 7793957; See PMID 9097431; uncharacterized protein 2245088 4986308 An12g09560 Aspergillus niger uncharacterized protein XP_001396008.1 2243392 D 5061 CDS An12g09565 84592736 complement(2246210..2246557) III 1 NT_166527.1 hypothetical protein 2246557 84592736 An12g09565 Aspergillus niger hypothetical protein XP_059606971.1 2246210 R 5061 CDS An12g09570 84592737 complement(join(2246813..2247004,2247125..2247310)) III 1 NT_166527.1 hypothetical protein 2247310 84592737 An12g09570 Aspergillus niger hypothetical protein XP_059606972.1 2246813 R 5061 CDS An12g09580 4986311 join(2250773..2250916,2251000..2251608,2251678..2251829,2251886..2252056,2252111..2252452,2252527..2253130) III 1 NT_166527.1 Function: nit-4 is a pathway-specific regulatory gene in the nitrogen circuit of Neurospora crassa which is required for the expression of the structural genes for nitrate and nitrite reductase.; Remark: nit-4 possesses a single Zn(II)2Cys6 binuclear-type zinc finger, which may mediate DNA binding.; Title: similarity to nitrogen assimilation regulatory protein nit-4 - Neurospora crassa; nucleus; See PMID 1388109; See PMID 1840634; uncharacterized protein 2253130 4986311 An12g09580 Aspergillus niger uncharacterized protein XP_001396011.1 2250773 D 5061 CDS An12g09590 84592738 complement(join(2254742..2254897,2254981..2255029,2255154..2255233)) III 1 NT_166527.1 hypothetical protein 2255233 84592738 An12g09590 Aspergillus niger hypothetical protein XP_059606973.1 2254742 R 5061 CDS An12g09600 4986313 join(2255251..2255416,2255524..2255549,2255616..2255901,2255951..2256369) III 1 NT_166527.1 Function: TNA1 is the yeast high affinity nicotinic acid permease.; Induction: The transcript levels of TNA1 increase when extracellular nicotinic acid and thiamine,respectively, are absent.; Similarity: TNA1 belongs to the yeast Dal5p subfamily of the major facilitator family.; Title: similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563; uncharacterized protein 2256369 4986313 An12g09600 Aspergillus niger uncharacterized protein XP_001396013.3 2255251 D 5061 CDS An12g09610 84592739 complement(join(2256464..2256882,2256923..2257047,2257136..2258227,2258419..2258463,2258572..2258655,2258785..2258840)) III 1 NT_166527.1 Title: weak similarity to hypothetical extensin homolog HRGP2 - Glycine max; uncharacterized protein 2258840 84592739 An12g09610 Aspergillus niger uncharacterized protein XP_059606974.1 2256464 R 5061 CDS An12g09620 84592740 join(2259395..2259687,2259781..2259926,2260007..2260260) III 1 NT_166527.1 hypothetical protein 2260260 84592740 An12g09620 Aspergillus niger hypothetical protein XP_059606975.1 2259395 D 5061 CDS An12g09630 4986316 complement(join(<2260347..2260653,2260700..2262368)) III 1 NT_166527.1 Remark: Alterations of the azole target enzyme and the overexpression of multidrug efflux transporter genes are the most frequent azole resistance mechanisms in Candida albicans.; Remark: possible sequencing error at position 59218,2 bp too much.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans [putative frameshift]; putative frameshift; See PMID 11065353; uncharacterized protein 2262368 4986316 An12g09630 Aspergillus niger uncharacterized protein XP_059606976.1 2260347 R 5061 CDS An12g09640 4986317 complement(join(2263271..2263342,2263431..2263567,2263619..2263763,2263831..2264787,2264857..2264916)) III 1 NT_166527.1 Title: strong similarity to hypothetical GTP cyclohydrolase CAB65619.1 - Schizosaccharomyces pombe; uncharacterized protein 2264916 4986317 An12g09640 Aspergillus niger uncharacterized protein XP_059606977.1 2263271 R 5061 CDS An12g09650 4986318 complement(join(2265484..2266106,2266159..2266335,2266389..2266716,2266765..2266920)) III 1 NT_166527.1 Title: strong similarity to hypothetical uracil phosphoribosyltranferase SPAC1002.17 - Schizosaccharomyces pombe; uncharacterized protein 2266920 4986318 An12g09650 Aspergillus niger uncharacterized protein XP_001396018.1 2265484 R 5061 CDS An12g09660 4986319 join(2267297..2267712,2267767..2267962) III 1 NT_166527.1 Catalytic activity: UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.; Pathway: salvage pathway of pyrimidine metabolism.; Title: strong similarity to uracil phosphoribosyltransferase upp - Bacillus caldolyticus; See PMID 9268683; uncharacterized protein 2267962 4986319 An12g09660 Aspergillus niger uncharacterized protein XP_001396019.1 2267297 D 5061 CDS An12g09670 4986320 complement(join(2268376..2268433,2268488..2268692,2268762..2268862,2268922..2269069,2269135..2269300)) III 1 NT_166527.1 Catalytic activity: UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.; Pathway: Salvage pathway of pyrimidine metabolism.; Title: strong similarity to uracil phosphoribosyltransferase UPRT - Toxoplasma gondii; See PMID 9247925; uncharacterized protein 2269300 4986320 An12g09670 Aspergillus niger uncharacterized protein XP_001396020.1 2268376 R 5061 CDS An12g09680 4986321 join(2270493..2270612,2270669..2270854,2270910..2271080,2271132..2271296,2271349..2272147,2272202..2272536) III 1 NT_166527.1 Catalytic activity: 2-methyl-3-oxopropanoate + CoA + NAD(+) = propanoyl-CoA + CO(2) + NADH.; Title: strong similarity to methylmalonate-semialdehyde dehydrogenase precursor MMSDH -Bos taurus; See PMID 8514806; uncharacterized protein 2272536 4986321 An12g09680 Aspergillus niger uncharacterized protein XP_059606978.1 2270493 D 5061 CDS An12g09690 84592741 complement(join(2273081..2273184,2273268..2273385)) III 1 NT_166527.1 hypothetical protein 2273385 84592741 An12g09690 Aspergillus niger hypothetical protein XP_059606979.1 2273081 R 5061 CDS An12g09700 4986323 join(2274098..2274449,2274562..2275214) III 1 NT_166527.1 Complex: PRAP (PRL Receptor Associated Protein) is an ovarian-specific protein that associates with the short form of the prolactin receptor.; Function: PRAP may contribute to the luteotropic effects of PRL on the corpus luteum during pregnancy.; Remark: Prolactin (PRL) is essential for progesterone biosynthesis and luteal cell hypertrophy of the rat corpus luteum during pregnancy.; Title: similarity to ovarian-specific phosphoprotein PRAP - Rattus norvegicus; See PMID 8663045; uncharacterized protein 2275214 4986323 An12g09700 Aspergillus niger uncharacterized protein XP_001396023.1 2274098 D 5061 CDS An12g09710 4986324 complement(join(2276200..2276960,2277041..2277881,2278080..2278121)) III 1 NT_166527.1 Title: weak similarity to hypothetical protein SCH63.38 - Streptomyces coelicolor; uncharacterized protein 2278121 4986324 An12g09710 Aspergillus niger uncharacterized protein XP_001396024.3 2276200 R 5061 CDS An12g09720 4986325 join(2278825..2278882,2278952..2279523,2279591..2279635,2279759..2280036,2280095..2280200,2280254..2280357,2280413..2280572,2280637..2280784,2280852..2281015,2281064..2281444,2281619..2281696) III 1 NT_166527.1 Function: Ecm10 is involved in protein folding and assembling/disassembling of protein complexes.; Remark: Besides Ssc1 and Ssq1, Ecm10 is the third Hsp70 protein identified in the mitochondrial matrix.; Similarity: Ecm10 belongs to the heat shock protein 70 (Hsp70) superfamily.; Title: similarity to dnaK-type molecular chaperone Ecm10 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 11150530; uncharacterized protein 2281696 4986325 An12g09720 Aspergillus niger uncharacterized protein XP_059606980.1 2278825 D 5061 CDS An12g09750 4986328 join(2283040..2283430,2283497..2283940,2284011..2284192) III 1 NT_166527.1 Title: strong similarity to hypothetical protein CAD70289.1 - Neurospora crassa; uncharacterized protein 2284192 4986328 An12g09750 Aspergillus niger uncharacterized protein XP_001396026.1 2283040 D 5061 CDS An12g09760 4986329 complement(join(2284498..2285522,2285575..2285640,2285689..2286256)) III 1 NT_166527.1 Title: strong similarity to hypothetical protein BAC67939.1 - Streptomyces avermitilis; uncharacterized protein 2286256 4986329 An12g09760 Aspergillus niger uncharacterized protein XP_001396027.1 2284498 R 5061 CDS An12g09770 84592742 join(2287128..2287235,2287295..2287313,2287526..2287768,2288084..2288940) III 1 NT_166527.1 Function: Bfr1+ serves as an efflux pump that confers resistance to brefeldin A and various antibiotics.; Similarity: Bfr1+ protein is a member of the ATP-binding cassette superfamily.; Similarity: The bfr1+ protein exhibits significant homology in primary and secondary structures with two multidrug resistance gene products of S. cerevisiae, Snq2 and Sts1/Pdr5/Ydr1.; Similarity: The structural characteristic of bfr1+ protein resembles that of mammalian P-glycoprotein, which is responsible for multidrug resistance in tumor cells.; Title: similarity to brefeldin A resistance protein bfr1p - Schizosaccharomyces pombe; See PMID 7883711; uncharacterized protein 2288940 84592742 An12g09770 Aspergillus niger uncharacterized protein XP_059606981.1 2287128 D 5061 CDS An12g09780 4986331 complement(join(2289496..2289600,2289692..2290625,2290716..2290723)) III 1 NT_166527.1 Title: weak similarity to alkyl salicylate esterase salE - Acinetobacter sp.; uncharacterized protein 2290723 4986331 An12g09780 Aspergillus niger uncharacterized protein XP_001396029.3 2289496 R 5061 CDS An12g09790 4986332 complement(join(2291377..2291451,2291591..2291687,2291754..2292484,2292541..2292633,2292683..2292724)) III 1 NT_166527.1 hypothetical protein 2292724 4986332 An12g09790 Aspergillus niger hypothetical protein XP_001396030.3 2291377 R 5061 CDS An12g09800 84592743 join(2293197..2293331,2293385..2293690,2293740..2293913) III 1 NT_166527.1 hypothetical protein 2293913 84592743 An12g09800 Aspergillus niger hypothetical protein XP_059606982.1 2293197 D 5061 CDS An12g09810 4986334 complement(join(2294515..2294633,2294755..2294999,2295081..2295513,2295573..2295855)) III 1 NT_166527.1 Catalytic activity: An alcohol + NAD(+) = an aldehyde or ketone + NADH.; Function: AdhT catalyzes the oxidation of primary and secondary alcohols to aldehydes and ketones,respectively, by NAD+.; Pathway: Alcohol degradation.; Remark: AdhT is a zinc-metalloprotein.; Similarity: The deduced protein sequence of adhT shows significant similarity with the highly thermostable ADH from the thermoacidophilic archaebacterium Sulfolobus solfataricus.; Title: strong similarity to thermostable alcohol dehydrogenase adhT - Bacillus stearothermophilus; See PMID 8020473; uncharacterized protein 2295855 4986334 An12g09810 Aspergillus niger uncharacterized protein XP_001396032.3 2294515 R 5061 CDS An12g09820 4986335 join(2298484..2298628,2298696..2299079,2299196..2299326) III 1 NT_166527.1 Title: strong similarity to hypothetical protein encoded by An13g03360 - Aspergillus niger; uncharacterized protein 2299326 4986335 An12g09820 Aspergillus niger uncharacterized protein XP_001396033.3 2298484 D 5061 CDS An12g09830 4986336 join(2299924..2300013,2300078..2300277,2300349..2300455,2300504..2300853,2300911..2300965,2301021..2301183,2301418..2301682,2301758..2301793) III 1 NT_166527.1 Title: similarity to hypothetical protein SC1C3.21 -Streptomyces coelicolor; uncharacterized protein 2301793 4986336 An12g09830 Aspergillus niger uncharacterized protein XP_001396034.3 2299924 D 5061 CDS An12g09850 84592744 join(2303172..2303342,2303438..2303725) III 1 NT_166527.1 Title: weak similarity to cell wall protein Crh1 -Saccharomyces cerevisiae; uncharacterized protein 2303725 84592744 An12g09850 Aspergillus niger uncharacterized protein XP_059606983.1 2303172 D 5061 CDS An12g09860 4986339 join(2304262..2304480,2304532..2304675,2304731..2304810,2304861..2305656) III 1 NT_166527.1 Title: strong similarity to hypothetical protein CAD70545.1 - Neurospora crassa; uncharacterized protein 2305656 4986339 An12g09860 Aspergillus niger uncharacterized protein XP_001396036.1 2304262 D 5061 CDS An12g09870 84592745 complement(2306174..2306467) III 1 NT_166527.1 Remark: it looks like only a glycin, prolin rich region.; hypothetical protein 2306467 84592745 An12g09870 Aspergillus niger hypothetical protein XP_059606984.1 2306174 R 5061 CDS An12g09880 4986341 join(2306786..2306887,2306994..2307155,2307851..2308128,2308224..2308611) III 1 NT_166527.1 Catalytic activity: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate.; Pathway: cysteine metabolism; selenoamino acid metabolism; sulfur metabolism.; Remark: a pyridoxal-phosphate protein. Some alkyl thiols, cyanide, pyrazole and some other heterocyclic compounds can act as acceptors.; Remark: the rcs2 transcript of Oryza sativa accumulated in shoots grown in the light, but disappeared almost completely by dark treatment.; Title: strong similarity to cysteine synthase rcs2 -Oryza sativa; See PMID 10095115; uncharacterized protein 2308611 4986341 An12g09880 Aspergillus niger uncharacterized protein XP_001396038.3 2306786 D 5061 CDS An12g09890 84592746 complement(join(2309080..2309277,2309340..2309586,2309661..2310139)) III 1 NT_166527.1 Title: similarity to hypothetical protein encoded by An11g00960 - Aspergillus niger; uncharacterized protein 2310139 84592746 An12g09890 Aspergillus niger uncharacterized protein XP_059606985.1 2309080 R 5061 CDS An12g09900 4986343 join(2311030..2311351,2311405..2311916,2311975..2312136,2312184..2312759) III 1 NT_166527.1 Remark: amino acid transporters are essential participants in the resource allocation processes that support plant growth and development.; Remark: the transporter designated BAT1 (b(0,+)-type amino acid transporter 1) from rat kidney was found to be structurally related to recently identified amino acid transporters for system L, system y(+)L, and system x(-)C, which are linked, via a disulfide bond, to the other type II membrane glycoprotein, 4F2hc (4F2 heavy chain).; Title: strong similarity to amino acid transporter BAT1 - Rattus norvegicus; See PMID 10506124; See PMID 10748260; uncharacterized protein 2312759 4986343 An12g09900 Aspergillus niger uncharacterized protein XP_001396040.1 2311030 D 5061 CDS An12g09910 4986344 join(2313351..2313728,2313813..2314019) III 1 NT_166527.1 Remark: the Nudix family proteins, are fused to other domains and form multidomain proteins whose functions are known or could be predicted seem to be related to stress-response and elimination of damage products.; Similarity: to Nudix (MutT) family of pyrophosphohydrolases.; Title: similarity to mutator MutT/nudix family protein DR0329 - Deinococcus radiodurans; See PMID 11145417; uncharacterized protein 2314019 4986344 An12g09910 Aspergillus niger uncharacterized protein XP_059606986.1 2313351 D 5061 CDS An12g09920 84592747 complement(join(2314277..2314623,2314731..2315124)) III 1 NT_166527.1 Remark: weak similarity to Porphorymonas gingivalis protein PG123 patent WO9929870-A1.; Title: weak similarity to PG123 from patent WO9929870-A1 - Porphorymonas gingivalis; uncharacterized protein 2315124 84592747 An12g09920 Aspergillus niger uncharacterized protein XP_059606987.1 2314277 R 5061 CDS An12g09930 84592748 complement(join(2317212..2317349,2317443..2318091,2318535..2318611,2318645..2318767,2318845..2319116,2319205..2319376)) III 1 NT_166527.1 Remark: weak similarity to Vesicular stomatitis virus G stem polypeptide patent WO9932648-A1.; Title: weak similarity to virus G stem polypeptide from patent WO9932648-A1 - Vesicular stomatitis; See PMID 2168974; uncharacterized protein 2319376 84592748 An12g09930 Aspergillus niger uncharacterized protein XP_059606988.1 2317212 R 5061 CDS An12g09940 4986347 join(2319522..2319759,2319824..2320851) III 1 NT_166527.1 Catalytic activity: stearoyl-CoA + AH2 + O2 = oleoyl-CoA + A + 2 H2O.; Remark: delta 9-desaturase gene (Ole1), codes for a key enzyme involved in regulating membrane fluidity in animal cells and microorganisms.; Title: strong similarity to stearoyl-CoA desaturase ole1 - Ajellomyces capsulatus; See PMID 8538376; uncharacterized protein 2320851 4986347 An12g09940 Aspergillus niger uncharacterized protein XP_001396044.1 2319522 D 5061 CDS An12g09950 4986348 2321576..2322574 III 1 NT_166527.1 Catalytic activity: alcohol + NAD+ = aldehyde or ketone + NADH.; Pathway: glycolysis / gluconeogenesis; fatty acid metabolism; bile acid biosynthesis; tyrosine metabolism; glycerolipid metabolism.; Remark: ADH is a zinc protein. It acts on primary or secondary alcohols or hemiacetals; the animal, but not the yeast, enzyme acts also on cyclic secondary alcohols. The insect enzyme is a member of the nonmetallo-short-chain alcohol dehydrogenase (ADH) family.; Title: strong similarity to thermostable alcohol dehydrogenase adhT - Bacillus stearothermophilus; See PMID 10971204; See PMID 1735726; uncharacterized protein 2322574 4986348 An12g09950 Aspergillus niger uncharacterized protein XP_001396045.1 2321576 D 5061 CDS An12g09960 4986349 complement(join(2322643..2322688,2322830..2323062,2323121..2323386,2323443..2323740)) III 1 NT_166527.1 Title: strong similarity to hypothetical protein encoded by An12g02190 - Aspergillus niger; uncharacterized protein 2323740 4986349 An12g09960 Aspergillus niger uncharacterized protein XP_059606989.1 2322643 R 5061 CDS An12g09970 4986350 complement(join(2324656..2325351,2325404..2325513,2325598..2325628,2325670..2325782,2325958..2326105)) III 1 NT_166527.1 Title: similarity to hypothetical protein encoded by An12g02180 - Aspergillus niger; uncharacterized protein 2326105 4986350 An12g09970 Aspergillus niger uncharacterized protein XP_059606990.1 2324656 R 5061 CDS An12g09980 4986351 complement(join(2326952..2327061,2327125..2327556,2327628..2327736,2328111..2328199,2328234..2328316,2328635..2328665,2328825..2329614)) III 1 NT_166527.1 Remark: only a smalll part of the protein match the sequence.; Title: weak similarity to zinc-binding protein Rar1 - Toxoplasma gondii; See PMID 10571178; uncharacterized protein 2329614 4986351 An12g09980 Aspergillus niger uncharacterized protein XP_059606991.1 2326952 R 5061 CDS An12g09990 4986352 complement(join(2332137..2332173,2332346..2332383,2332655..2333521,2333652..2333756,2333831..2333989)) III 1 NT_166527.1 Title: similarity to hypothetical protein encoded by An16g06080 - Aspergillus niger; uncharacterized protein 2333989 4986352 An12g09990 Aspergillus niger uncharacterized protein XP_059606992.1 2332137 R 5061 CDS An12g10000 4986353 join(2335596..2335718,2335789..2335859,2335914..2335937,2335998..2336087,2336139..2336221,2336280..2336677,2336724..2337053,2337112..2337591) III 1 NT_166527.1 Remark: transcript level analyses demonstrate that gabA is subject to carbon catabolite and nitrogen metabolite repression.; Similarity: to other choline transport proteins.; Title: strong similarity to GABA permease gabA -Aspergillus nidulans; See PMID 10320578; uncharacterized protein 2337591 4986353 An12g10000 Aspergillus niger uncharacterized protein XP_001396050.1 2335596 D 5061 CDS An12g10020 4986355 join(2338718..2338954,2339016..2340641) III 1 NT_166527.1 Catalytic activity: an aromatic primary alcohol + O2 = an aromatic aldehyde + H2O2.; Remark: aao from Pleurotus eryngii presents wide specificity, showing activity on benzyl, cinnamyl, naphthyl and aliphatic unsaturated alcohols.; Remark: aryl-alcohol oxidase is a unique flavoprotein with 15% carbohydrate content.; Title: strong similarity to aryl-alcohol oxidase precursor aao - Pleurotus eryngii; See PMID 1425667; uncharacterized protein 2340641 4986355 An12g10020 Aspergillus niger uncharacterized protein XP_001396051.1 2338718 D 5061 CDS An12g10030 4986356 complement(join(2340923..2341587,2341639..2341852)) III 1 NT_166527.1 Remark: rev7 is involved in polarity establishment/cellular polarization during budding.; Title: weak similarity to membrane protein YIL140w Rev7 - Saccharomyces cerevisiae; See PMID 7871890; uncharacterized protein 2341852 4986356 An12g10030 Aspergillus niger uncharacterized protein XP_059606993.1 2340923 R 5061 CDS An12g10050 4986358 join(2343417..2343604,2343660..2343733,2343795..2344648) III 1 NT_166527.1 Remark: can be used in a method to produce aromatic hydrocarbons, particularly catechol which is used in the development of pharmaceuticals such as L-DOPA and adrenaline, agrobiochemicals such as carbofuran, and antioxidants such as 4-tert-butyl catechol and veratol.; Remark: similarity to Aspergillus niger 2,3-dihydroxybenzoic acid decarboxylase patent WO9909048-A1.; Title: similarity to 2,3-dihydroxybenzoic acid decarboxylase from patent WO9909048-A1 - Aspergillus niger; uncharacterized protein 2344648 4986358 An12g10050 Aspergillus niger uncharacterized protein XP_059606994.1 2343417 D 5061 CDS An12g10060 4986359 complement(2344998..2345960) III 1 NT_166527.1 Remark: also show homology to different oxidoreductases.; Remark: strong similarity to human breast tumour-associated protein 77 patent DE19813839-A1.; Title: strong similarity to breast tumour-associated protein 77 from patent DE19813839-A1 - Homo sapiens; uncharacterized protein 2345960 4986359 An12g10060 Aspergillus niger uncharacterized protein XP_001396054.1 2344998 R 5061 CDS An12g10080 84592749 complement(join(2347020..2347453,2347585..2347648,2347712..2348050)) III 1 NT_166527.1 hypothetical protein 2348050 84592749 An12g10080 Aspergillus niger hypothetical protein XP_059606995.1 2347020 R 5061 CDS An12g10090 4986362 complement(join(2348395..2348796,2348869..2351054,2351112..2351379,2351438..2351731)) III 1 NT_166527.1 Catalytic activity: L-2-Aminoadipate 6-semialdehyde + NAD+ or NADP+ + H2O = L-2-Aminoadipate + NADH or NADPH.; Pathway: sixth step in lysine biosynthesis; lysine degradation.; Remark: lys2 from S. cerevisiae catalyzes the activation of 2-aminoadipate by ATP-dependent adenylation,and the reduction of activated 2-aminoadipate. Together with lys5 protein, it catalyzes the overall interconversion of 2-aminoadipate and 2-aminoadipic-2-semialdehyde. It may be a component of the enzyme complex L-aminoadipate-semialdehyde dehydrogenase.; Title: strong similarity to L-aminoadipate-semialdehyde dehydrogenase Lys2 -Saccharomyces cerevisiae; See PMID 2013406; See PMID 7900426; uncharacterized protein 2351731 4986362 An12g10090 Aspergillus niger uncharacterized protein XP_001396056.1 2348395 R 5061 CDS An12g10100 4986363 complement(join(2352336..2353177,2353234..2353426)) III 1 NT_166527.1 Title: strong similarity to hypothetical membrane protein YDL144c - Saccharomyces cerevisiae; uncharacterized protein 2353426 4986363 An12g10100 Aspergillus niger uncharacterized protein XP_001396057.1 2352336 R 5061 CDS An12g10110 4986364 join(2353777..2354922,2355119..2355958) III 1 NT_166527.1 Remark: ARGR2 from yeast is a positive and negative regulator of many arginine-responsive genes.; Remark: there is evidence that ArgRII is the sensor of the effector arginine and that the binding site of arginine would be the region downstream from the zinc cluster, sharing some identity with the arginine binding domain of bacterial arginine repressors.; Similarity: to unassigned GAL4-type zinc cluster proteins; GAL4 zinc binuclear cluster homology.; Title: similarity to transcription factor Arg81 -Saccharomyces cerevisiae; See PMID 3709534; See PMID 10688655; uncharacterized protein 2355958 4986364 An12g10110 Aspergillus niger uncharacterized protein XP_059606996.1 2353777 D 5061 CDS An12g10120 4986365 complement(join(2356031..2356105,2356156..2356687,2356744..2357021)) III 1 NT_166527.1 Remark: adducin is a ubiquitously expressed membrane-skeletal protein localized at spectrin-actin junctions that binds calmodulin and is an in vivo substrate for protein kinase C (PKC) and Rho-associated kinase.; Remark: the human adducin is approximately 400 amino acids longer.; Similarity: to adducins of different organisms.; Title: strong similarity to adducin alpha chain (splice form 1) ADD1 - Homo sapiens; See PMID 10950304; See PMID 1840603; uncharacterized protein 2357021 4986365 An12g10120 Aspergillus niger uncharacterized protein XP_001396059.1 2356031 R 5061 CDS An12g10130 4986366 2357630..2359246 III 1 NT_166527.1 Remark: prnB A. nidulans, encoding the major proline transport system is one of a cluster of four genes necessary and sufficient for the utilization of proline as sole nitrogen and/or carbon source.; Remark: the proline utilisation gene cluster of Aspergillus nidulans can be repressed efficiently only when both repressing nitrogen and repressing carbon sources are present.; Title: strong similarity to proline permease prnB -Aspergillus nidulans; See PMID 2664423; See PMID 8437566; uncharacterized protein 2359246 4986366 An12g10130 Aspergillus niger uncharacterized protein XP_001396060.1 2357630 D 5061 CDS An12g10140 4986367 complement(join(2359354..2359429,2359490..2359566,2359621..2359874,2359926..2360000,2360053..2360217,2360270..2360699,2360762..2360848)) III 1 NT_166527.1 Catalytic activity: (S)-2-hydroxy acid + O2 = 2-oxo acid + h2O2.; Pathway: Glyoxylate and dicarboxylate metabolism.; Remark: the IRE-like sequence in mouse GOX exhibited strong binding to IRPs at room temperature.; Title: strong similarity to glycolate oxidase GOX -Mus musculus; See PMID 9891009; uncharacterized protein 2360848 4986367 An12g10140 Aspergillus niger uncharacterized protein XP_059606997.1 2359354 R 5061 CDS An12g10150 4986368 join(2361213..2361941,2361994..2363058) III 1 NT_166527.1 Catalytic activity: RCH2NH2 + H2O + O2 = RCHO + NH3 + H2O2.; Pathway: glycine, serine and threonine metabolism; arginine and proline metabolism; histidine metabolism; tyrosine metabolism; phenylalanine metabolism; tryptophan metabolism.; Remark: flavoprotein(FAD). Acts on primary amines,and usually also on some secondary and tertiary amines.; Remark: trout MAO oxidizes both serotonin [5-hydroxytryptamine (5-HT)] and beta-phenylethylamine (PEA).; Title: strong similarity to monoamine oxidase MAO -Oncorhynchus mykiss; See PMID 7808446; uncharacterized protein 2363058 4986368 An12g10150 Aspergillus niger uncharacterized protein XP_059606998.1 2361213 D 5061 CDS An12g10160 4986369 2363544..2364812 III 1 NT_166527.1 Title: similarity to hypothetical UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase C1galt1 - Rattus norvegicus; uncharacterized protein 2364812 4986369 An12g10160 Aspergillus niger uncharacterized protein XP_001396063.1 2363544 D 5061 CDS An12g10170 4986370 complement(join(2364987..2365026,2365154..2365629)) III 1 NT_166527.1 Title: weak similarity to hypothetical PxORF73 peptide Pxorf73 - Plutella xylostella; uncharacterized protein 2365629 4986370 An12g10170 Aspergillus niger uncharacterized protein XP_059606999.1 2364987 R 5061 CDS An12g10180 4986371 complement(join(2367229..2368202,2368265..2368808)) III 1 NT_166527.1 Title: strong similarity to hypothetical protein BAC67939.1 - Streptomyces avermitilis; uncharacterized protein 2368808 4986371 An12g10180 Aspergillus niger uncharacterized protein XP_059607000.1 2367229 R 5061 CDS An12g10190 4986372 complement(join(2370620..2370870,2370931..2371248,2371304..2371405,2371459..2371815,2371863..2371985,2372033..2372193,2372260..2372404,2372491..2372503)) III 1 NT_166527.1 Remark: Tna1p is necessary for nicotinic acid import into the cell.; Similarity: belongs to the allantoate permease family; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563; uncharacterized protein 2372503 4986372 An12g10190 Aspergillus niger uncharacterized protein XP_001396066.1 2370620 R 5061 CDS An12g10200 84592750 complement(2373696..2374676) III 1 NT_166527.1 Remark: the protein shows partial homology to ice nucleation proteins.; Title: weak similarity to ice nucleation gene inaX -Xanthomonas campestris; See PMID 2259339; uncharacterized protein 2374676 84592750 An12g10200 Aspergillus niger uncharacterized protein XP_059607001.1 2373696 R 5061 CDS An12g10210 10098163 join(<2375676..2375940,2376017..2376148,2376210..2376340,2376550..>2376791) III 1 NT_166527.1 Title: similarity to hypothetical protein CAD21295.1 - Neurospora crassa; 2376791 10098163 An12g10210 Aspergillus niger 2375676 D 5061 CDS An12g10220 4986375 join(2377660..2377694,2377765..2377853,2377890..2377961,2378051..2378185,2378268..2378492,2378679..2378818,2379240..2379273,2379355..2379472,2379520..2379649) III 1 NT_166527.1 Function: oxidation of leucoanthocyanidins into anthocyanidins.; Pathway: flavonoid synthesis; anthocyanidins biosynthesis.; Remark: steady-state level of mRNAs encoded by the flavonoid biosynthetic genes as determined in young seedlings is coordinately induced by light.; Similarity: belongs to the iron/ascorbate-dependent family of oxidoreductases.; Title: similarity to leucoanthocyanidin dioxygenase LDOX - Vitis vinifera; See PMID 8193299; uncharacterized protein 2379649 4986375 An12g10220 Aspergillus niger uncharacterized protein XP_059607002.1 2377660 D 5061 CDS An12g10230 4986376 2380199..2381155 III 1 NT_166527.1 Remark: atf21 regulates meiosis and mitosis in fission yeast by two branches of a MAP kinase cascade.; Title: similarity to ATF/CREB-family transcription factor atf21p - Schizosaccharomyces pombe; See PMID 8824587; See PMID 10102365; uncharacterized protein 2381155 4986376 An12g10230 Aspergillus niger uncharacterized protein XP_001396069.1 2380199 D 5061 CDS An12g10240 4986377 complement(join(2381887..2382075,2382134..2382259)) III 1 NT_166527.1 Remark: expression of the con-10 gene in various mutants defective at different stages of conidiation indicates that it plays a role after aerial hyphal development.; Title: strong similarity to conidiation-specific protein pCon-10a - Neurospora crassa; See PMID 2970007; uncharacterized protein 2382259 4986377 An12g10240 Aspergillus niger uncharacterized protein XP_059607003.1 2381887 R 5061 CDS An12g10250 4986378 complement(join(2383639..2384515,2384564..2384604,2384650..2384885,2384938..2385102,2385159..2385402,2385509..2385760)) III 1 NT_166527.1 Catalytic activity: Phenol + NADPH + O2 = Catechol + NADP+ + H2O.; Pathway: phenylalanine metabolism; toluene degradation.; Remark: southern blot analysis revealed the presence of phenol hydroxylase gene-related sequences in a number of T. cutaneum and Trichosporon beigelii strains and in Cryptococcus elinovii but not in Trichosporon pullulans,Trichosporon penicillatum, or Candida tropicalis.; Title: strong similarity to phenol 2-monooxygenase -Trichosporon beigelii; See PMID 1429434; uncharacterized protein 2385760 4986378 An12g10250 Aspergillus niger uncharacterized protein XP_001396071.1 2383639 R 5061 CDS An12g10260 84592751 complement(join(2386232..2386381,2386477..2386519,2386612..2386706)) III 1 NT_166527.1 hypothetical protein 2386706 84592751 An12g10260 Aspergillus niger hypothetical protein XP_059607004.1 2386232 R 5061 CDS An12g10270 84592752 join(2388462..2388526,2388762..2388893,2388920..2389138,2389324..2389532,2389615..2389966,2389971..2390100) III 1 NT_166527.1 Catalytic activity: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine.; Pathway: propanoate metabolism.; Remark: comparative analysis of structural and expression characteristics of ACC synthase genes from Arabidopsis and other plant species suggests that the sequence divergence of the ACC synthase genes and possibly the distinct regulatory networks governing the expression of ACC synthase subfamilies arose early in plant evolution and before the divergence of monocots and dicots.; Title: similarity to 1-aminocyclopropane-1-carboxylate synthase ACS1 -Arabidopsis thaliana; See PMID 8566772; See PMID 1438312; uncharacterized protein 2390100 84592752 An12g10270 Aspergillus niger uncharacterized protein XP_059607005.1 2388462 D 5061 CDS An12g10280 4986381 join(2390984..2391635,2391713..2393292) III 1 NT_166527.1 Remark: the protein seems approximately N-terminal 200 amino acids shorter.; Title: similarity to hypothetical protein 1A9.40 -Neurospora crassa; uncharacterized protein 2393292 4986381 An12g10280 Aspergillus niger uncharacterized protein XP_001396074.1 2390984 D 5061 CDS An12g10290 4986382 join(2394258..2394354,2395103..2395375,2395569..2396650) III 1 NT_166527.1 Phenotype: mutations in S. cerevisiae HOL1 confer the ability of cells to take up histidinol from the medium.; Similarity: to ion transporters similar to the major facilitator superfamily of transporters.; Title: similarity to multidrug resistance protein Hol1 - Saccharomyces cerevisiae; See PMID 2405251; See PMID 8955402; uncharacterized protein 2396650 4986382 An12g10290 Aspergillus niger uncharacterized protein XP_059607006.1 2394258 D 5061 CDS An12g10300 84592753 complement(join(2397057..2397452,2397522..2397636,2397697..2397899,2397986..2398093)) III 1 NT_166527.1 Remark: only a part of the protein match to serine/threonine protein kinase-like protein in Arabidopsis thaliana.; hypothetical protein 2398093 84592753 An12g10300 Aspergillus niger hypothetical protein XP_059607007.1 2397057 R 5061 CDS An12g10310 84592754 join(2398230..2398603,2398656..2398704) III 1 NT_166527.1 hypothetical protein 2398704 84592754 An12g10310 Aspergillus niger hypothetical protein XP_059607008.1 2398230 D 5061 CDS An12g10320 4986385 join(2400956..2401135,2401178..2401975) III 1 NT_166527.1 Function: high affinity zinc transport protein.; Remark: also strong similarity to metal-regulated transporter polypeptide ZRT2 in Arabidopsis thaliana patent WO9745000-A1.; Similarity: to other zinc transport proteins of Arabidopsis thaliana, Schizosaccharomyces pombe.; Title: strong similarity to high affinity zinc transport protein Zrt1 - Saccharomyces cerevisiae; See PMID 8322518; uncharacterized protein 2401975 4986385 An12g10320 Aspergillus niger uncharacterized protein XP_059607009.1 2400956 D 5061 CDS An12g10330 4986386 complement(2403566..>2404168) III 1 NT_166527.1 Remark: N-terminal truncated ORF due to end of contig.; Title: weak similarity to hypothetical protein encoded by An02g14500 - Aspergillus niger [truncated ORF]; uncharacterized protein 2404168 4986386 An12g10330 Aspergillus niger uncharacterized protein XP_001396079.1 2403566 R 5061 CDS An12g10340 4986387 complement(join(2406428..2407153,2407210..2407326)) III 1 NT_166527.1 Similarity: shows similarity to N-terminal half of purine-cytosine permease homolog yxlA of B. subtilis and to N-terminal half of hypothetical proteins of M. pneumoniae and M . genitalium. .; Title: weak similarity to hypothetical purine-cytosine permease homolog yxlA - Bacillus subtilis; uncharacterized protein 2407326 4986387 An12g10340 Aspergillus niger uncharacterized protein XP_001396080.1 2406428 R 5061 CDS An12g10350 4986388 complement(join(2408400..2408445,2408503..2408570,2408634..2408768)) III 1 NT_166527.1 Title: strong similarity to hypothetical protein encoded by An15g07090 - Aspergillus niger; uncharacterized protein 2408768 4986388 An12g10350 Aspergillus niger uncharacterized protein XP_001396081.1 2408400 R 5061 CDS An12g10360 4986389 complement(join(2410308..2411204,2411268..2411486)) III 1 NT_166527.1 Title: similarity to hypothetical protein encoded by An08g08280 - Aspergillus niger; uncharacterized protein 2411486 4986389 An12g10360 Aspergillus niger uncharacterized protein XP_001396082.1 2410308 R 5061 CDS An12g10370 84592755 join(2414534..2415294,2415345..2415381) III 1 NT_166527.1 hypothetical protein 2415381 84592755 An12g10370 Aspergillus niger hypothetical protein XP_059601975.1 2414534 D 5061 CDS An12g10380 4986391 complement(join(2415814..2415951,2416014..2417690,2417807..2418168,2418230..2418623,2418697..2418780)) III 1 NT_166527.1 Catalytic activity: chitin synthase catalyzes the conversion of UDP-N-acetyl-D-glucosamine + [1,4-(N-Acetyl-beta-D-glucosaminyl)]n = UDP + [1,4-(N-Acetyl-beta-D-glucosaminyl)]n+1.; Function: chitin synthase catalyzes the alpha-1,4-glycosylation of chitin by UDP-N-acetyl-D-glucosamine producing elongated chitin and UDP.; Title: strong similarity to chitin synthase C chsC -Aspergillus fumigatus; uncharacterized protein 2418780 4986391 An12g10380 Aspergillus niger uncharacterized protein XP_001396084.1 2415814 R 5061 CDS An12g10390 4986392 complement(join(2422180..2423414,2423493..2423823)) III 1 NT_166527.1 Function: The tannase of A. oryzae hydrolyzes the ester bonds of tannic acid to produce gallic acid and glucose.; Title: similarity to precursor of tannase -Aspergillus oryzae; See PMID 8917102; uncharacterized protein 2423823 4986392 An12g10390 Aspergillus niger uncharacterized protein XP_001396085.1 2422180 R 5061 CDS An12g10400 4986393 complement(2425139..2426311) III 1 NT_166527.1 Similarity: shows similarity to C-terminal part of PA1406 of P. aeruginosa.; Title: similarity to hypothetical protein encoded by An16g01890 - Aspergillus niger; uncharacterized protein 2426311 4986393 An12g10400 Aspergillus niger uncharacterized protein XP_059601976.1 2425139 R 5061 CDS An12g10410 4986394 complement(join(2427810..2428738,2428823..2429117)) III 1 NT_166527.1 Catalytic activity: UDPglucose = UDPgalactose.; Pathway: galactose metabolism; nucleotide sugars metabolism.; Remark: the enzyme requires NAD+. Also acts on UDP-2-deoxyglucose.; Title: strong similarity to UDP-Glc-4-epimerase galE - Escherichia coli; See PMID 10531250; uncharacterized protein 2429117 4986394 An12g10410 Aspergillus niger uncharacterized protein XP_059601977.1 2427810 R 5061 CDS An12g10420 84592756 complement(join(2430806..2431126,2431383..2431776,2431880..2431983)) III 1 NT_166527.1 Remark: spherulin 4 from Physarum polycephalum accumulates during spherulation.; Title: similarity to developmentally regulated spherulin 4 - Physarum polycephalum; See PMID 2930775; uncharacterized protein 2431983 84592756 An12g10420 Aspergillus niger uncharacterized protein XP_059601978.1 2430806 R 5061 CDS An12g10430 4986396 complement(join(2432299..2432573,2432736..2433018,2433119..2433470,2433535..2433832,2433915..2434014)) III 1 NT_166527.1 Remark: it seems that there has been an gene duplication with 22CK but the similarity here is much better.; Remark: spherulin 4 from Physarum polycephalum accumulates during spherulation.; Title: strong similarity to developmentally regulated spherulin 4 - Physarum polycephalum; See PMID 2930775; uncharacterized protein 2434014 4986396 An12g10430 Aspergillus niger uncharacterized protein XP_059601979.1 2432299 R 5061 CDS An12g10440 4986397 join(2434536..2434604,2434673..2434775,2434848..2435752,2435803..2437716,2437800..2441967,2442020..2442479,2442538..2442748,2442809..2443432) III 1 NT_166527.1 Title: strong similarity to hypothetical protein CAD70539.1 - Neurospora crassa; uncharacterized protein 2443432 4986397 An12g10440 Aspergillus niger uncharacterized protein XP_059601980.1 2434536 D 5061 CDS An12g10450 4986398 complement(join(2443555..2443865,2443900..2443952,2444231..2445009)) III 1 NT_166527.1 Title: weak similarity to hypothetical protein SCC88.10c - Streptomyces coelicolor; uncharacterized protein 2445009 4986398 An12g10450 Aspergillus niger uncharacterized protein XP_059601981.1 2443555 R 5061 CDS An12g10460 84592757 join(2445627..2446000,2446032..2446110) III 1 NT_166527.1 Title: weak similarity to hypothetical protein encoded by Orf10 - Yersinia enterocolitica; uncharacterized protein 2446110 84592757 An12g10460 Aspergillus niger uncharacterized protein XP_059601982.1 2445627 D 5061 CDS An12g10470 4986400 join(2447248..2447392,2447444..2449806,2449875..2450385,2450509..2450654) III 1 NT_166527.1 Remark: only repetitive sequences are shown homology.; Title: weak similarity to retinitis pigmentosa GTPase regulator RPGR - Homo sapiens; uncharacterized protein 2450654 4986400 An12g10470 Aspergillus niger uncharacterized protein XP_001396093.3 2447248 D 5061 CDS An12g10480 4986401 join(2451305..2451318,2451379..2455043,2455083..2455363,2455437..>2455772) III 1 NT_166527.1 Remark: C-terminal truncated ORF due to end of contig.; Remark: the SEN1 gene, which is essential for growth in the yeast S. cerevisiae, is required for endonucleolytic cleavage of introns from all 10 families of precursor tRNAs.; Title: similarity to protein Sen1 - Saccharomyces cerevisiae [truncated ORF]; See PMID 1569945; uncharacterized protein 2455772 4986401 An12g10480 Aspergillus niger uncharacterized protein XP_059601983.1 2451305 D 5061 CDS An12g10490 4986402 join(2457262..2457729,2457798..2457986,2458051..2458334,2458387..2458510) III 1 NT_166527.1 Title: weak similarity to WbpV - Pseudomonas aeruginosa; See PMID 10627048; uncharacterized protein 2458510 4986402 An12g10490 Aspergillus niger uncharacterized protein XP_001396095.1 2457262 D 5061 CDS An12g10500 4986403 complement(join(2458785..2458860,2458914..2459741,2459810..2460172,2460205..2460359)) III 1 NT_166527.1 Remark: also strong similarity to patent FR2728905-A1 which is also the stereospecific, heat-stable amino acid amidohydrolase from B. stearothermophilus.; Remark: the deacetylating capacity of purified aminoacylase Bacillus stearothermophilus varies considerably depending on the nature of the amino acid residue in the substrate.; Similarity: belongs to peptidase M40, also known as the AMA/HIPO/HYUC family of hydrolases.; Title: strong similarity to N-carbamyl-L-amino acid amidohydrolase amaB - Bacillus stearothermophilus; See PMID 8285691; See PMID 9023955; uncharacterized protein 2460359 4986403 An12g10500 Aspergillus niger uncharacterized protein XP_059601984.1 2458785 R 5061 CDS An12g10510 4986404 2460653..2462920 III 1 NT_166527.1 Remark: the predicted ORF probably encodes a fusion protein between a acetylornithine deacetylase (EC 3. 5. 1. 16) (C-terminal) and a dehydratase (N-terminal), as the predicted ORF has a 359 amino acid extention at the N-terminus compaired to argE of M. xanthus, which shows similarity to threonine dehydratases (EC 4. 2. 1. 16).; Title: similarity to acetylornithine deacetylase argE - Myxococcus xanthus; See PMID 8092856; See PMID 9829957; uncharacterized protein 2462920 4986404 An12g10510 Aspergillus niger uncharacterized protein XP_001396097.1 2460653 D 5061 CDS An12g10520 4986405 2463372..2465084 III 1 NT_166527.1 Remark: Meis1 from Homo sapiens encodes a homeobox protein belonging to the TALE (three amino acid loop extension) family of homeodomain-containing proteins.; Remark: the similarity is only in the homeodomain in the found proteins.; Similarity: belongs to the TALE/MEIS family of homeobox proteins.; Title: similarity to Meis1-related protein 2 MRG2 -Homo sapiens; See PMID 9049632; uncharacterized protein 2465084 4986405 An12g10520 Aspergillus niger uncharacterized protein XP_059601985.1 2463372 D 5061 CDS An12g10530 84592758 complement(2466257..2467912) III 1 NT_166527.1 Title: similarity to kinesin light chain KLC -Plectonema boryanum; uncharacterized protein 2467912 84592758 An12g10530 Aspergillus niger uncharacterized protein XP_059601986.1 2466257 R 5061 CDS An12g10540 84592759 join(2468722..2468882,2469201..2469280,2469298..2469455) III 1 NT_166527.1 Similarity: shows similarity to N-terminal part of mrsA of M. tuberculosis.; Title: weak similarity to hypothetical phosphoglucomutase or phosphomannomutase mrsA -Mycobacterium tuberculosis; uncharacterized protein 2469455 84592759 An12g10540 Aspergillus niger uncharacterized protein XP_059601987.1 2468722 D 5061 CDS An12g10550 4986408 complement(join(2470787..2470933,2470997..2471270,2471331..2472347,2472405..2473121,2473177..2474340,2474500..2474558)) III 1 NT_166527.1 Similarity: shows similarity to several sensor/response regulator proteins, the similarity is restricted to the His Kinase A phosphoacceptor domain and Histidine kinase-ATPase domain.; Title: similarity to histidine protein kinase/response regulator luxQ - Vibrio harveyi; uncharacterized protein 2474558 4986408 An12g10550 Aspergillus niger uncharacterized protein XP_059601988.1 2470787 R 5061 CDS An12g10560 4986409 join(2475566..2476169,2476250..2476408,2476470..2476870) III 1 NT_166527.1 Similarity: aminoacids 5-257 show similarity to N-terminal half of S. cerevisiae Gal80p.; Similarity: shows similarity to several oxidoreductases.; Title: similarity to negative regulator for expression of galactose-induced genes Gal80 - Saccharomyces cerevisiae; uncharacterized protein 2476870 4986409 An12g10560 Aspergillus niger uncharacterized protein XP_001396102.1 2475566 D 5061 CDS An12g10570 4986410 complement(join(2477099..2477159,2477212..2477364,2477432..2477594,2477664..2478308,2478539..2478749,2478933..2479664)) III 1 NT_166527.1 Title: weak similarity to hypothetical isoflavone reductase homolog F18A5.50 - Arabidopsis thaliana; uncharacterized protein 2479664 4986410 An12g10570 Aspergillus niger uncharacterized protein XP_001396103.3 2477099 R 5061 CDS An12g10580 4986411 join(2479966..2480216,2480248..2480923) III 1 NT_166527.1 Title: similarity to hypothetical protein 4 -Streptomyces coelicolor; uncharacterized protein 2480923 4986411 An12g10580 Aspergillus niger uncharacterized protein XP_059601989.1 2479966 D 5061 CDS An12g10590 4986412 complement(join(2481160..2481410,2481477..2482695)) III 1 NT_166527.1 hypothetical protein 2482695 4986412 An12g10590 Aspergillus niger hypothetical protein XP_001396105.1 2481160 R 5061 CDS An12g10600 4986413 complement(2483368..2484495) III 1 NT_166527.1 hypothetical protein 2484495 4986413 An12g10600 Aspergillus niger hypothetical protein XP_001396106.1 2483368 R 5061 CDS An12g10610 4986414 complement(join(2485050..2485354,2485410..2485547,2485606..2485971,2486038..2486293)) III 1 NT_166527.1 Similarity: shows similarity to several dihydroflavonol an cinnamoyl-coA reductases.; Title: similarity to aldehyde reductase ARII -Sporidiobolus salmonicolor; See PMID 10583966; uncharacterized protein 2486293 4986414 An12g10610 Aspergillus niger uncharacterized protein XP_059601990.1 2485050 R 5061 CDS An12g10620 84592760 join(2486627..2486992,2487059..2487467,2487572..2487681,2487915..2488556) III 1 NT_166527.1 Title: similarity to hypothetical transcription activator SPAC139.03 - Schizosaccharomyces pombe; uncharacterized protein 2488556 84592760 An12g10620 Aspergillus niger uncharacterized protein XP_059601991.1 2486627 D 5061 CDS An12g10630 4986416 complement(join(2489072..2490435,2490505..2490637)) III 1 NT_166527.1 Catalytic activity: acid phosphatase catalyzes the conversion of an orthophosphoric monoester + H2O = an alcohol + orthophosphate.; Title: similarity to acid phosphatase aphA -Aspergillus ficuum; uncharacterized protein 2490637 4986416 An12g10630 Aspergillus niger uncharacterized protein XP_001396109.1 2489072 R 5061 CDS An12g10640 4986417 complement(join(2491354..2492301,2492361..2492432)) III 1 NT_166527.1 Similarity: shows similarity to several hydroxyisoflavone reductases.; Title: similarity to 2-hydroxyisoflavone reductase IRL - Zea mays; uncharacterized protein 2492432 4986417 An12g10640 Aspergillus niger uncharacterized protein XP_001396110.1 2491354 R 5061 CDS An12g10650 4986418 complement(join(2493458..2493886,2493960..2494007)) III 1 NT_166527.1 Title: weak similarity to hypothetical protein DR0722 - Deinococcus radiodurans; uncharacterized protein 2494007 4986418 An12g10650 Aspergillus niger uncharacterized protein XP_059601992.1 2493458 R 5061 CDS An12g10660 4986419 join(2494624..2494757,2494843..2495864,2495918..2496050,2496099..2496308,2496344..2496520,2496577..2497252) III 1 NT_166527.1 Function: nirA of A. nidulans is a zinc finger transcription factor mediating nitrate induction of genes involved in nitrate assimilation (nitrate reductase,nitrite reductases and a nitrate permease, niaD, niiA and crnA, respectively).; Remark: the nitrate assimilation genes are induced by nitrate and repressed by ammonium at the transcriptional level.; Similarity: the ORF shows similarity to several transcriptional activators.; Title: similarity to nitrate assimilation regulatory protein nirA - Aspergillus nidulans; nucleus; uncharacterized protein 2497252 4986419 An12g10660 Aspergillus niger uncharacterized protein XP_059601993.1 2494624 D 5061 CDS An12g10670 4986420 join(2498239..2498396,2498438..2498799,2498858..2499014,2499071..2499160,2499212..2499245,2499302..2499513,2499566..2499638) III 1 NT_166527.1 Title: similarity to hypothetical lyase SC7E4.19 -Streptomyces coelicolor; uncharacterized protein 2499638 4986420 An12g10670 Aspergillus niger uncharacterized protein XP_059601994.1 2498239 D 5061 CDS An12g10680 4986421 join(2501098..2501393,2501491..2501768,2501818..2502188,2502238..2502912) III 1 NT_166527.1 Similarity: shows strong similarity to several hypothetical monooxygenases and epoxigenases of different organisms.; Title: strong similarity to hypothetical monooxygenase paxM - Penicillium paxilli; See PMID 11169115; uncharacterized protein 2502912 4986421 An12g10680 Aspergillus niger uncharacterized protein XP_001396114.1 2501098 D 5061 CDS An12g10690 84592761 2502985..2503665 III 1 NT_166527.1 hypothetical protein 2503665 84592761 An12g10690 Aspergillus niger hypothetical protein XP_059601995.1 2502985 D 5061 CDS An12g10700 4986423 complement(join(2506262..2506426,2506584..2507021,2507098..2507223)) III 1 NT_166527.1 Title: similarity to hypothetical protein SPAC1952.10c - Schizosaccharomyces pombe; uncharacterized protein 2507223 4986423 An12g10700 Aspergillus niger uncharacterized protein XP_059601996.1 2506262 R 5061 CDS An12g10710 4986424 complement(join(2508354..2508677,2508741..2509079)) III 1 NT_166527.1 Title: strong similarity to hypothetical protein SPAC869.06c - Schizosaccharomyces pombe; uncharacterized protein 2509079 4986424 An12g10710 Aspergillus niger uncharacterized protein XP_001396117.1 2508354 R 5061 CDS An12g10720 4986425 join(2509795..2510113,2510184..2510242,2510310..2510471,2510538..2510662,2510719..2510808,2510858..2511125,2511185..2511916) III 1 NT_166527.1 Catalytic activity: catalase catalyzes the converison of 2 H2O2 = O2 + 2 H2O.; Similarity: shows strong similarity to several catalases of different species.; Title: strong similarity to catalase kat -Methanosarcina barkeri; See PMID 10382262; uncharacterized protein 2511916 4986425 An12g10720 Aspergillus niger uncharacterized protein XP_001396118.1 2509795 D 5061 CDS An12g10730 4986426 2512450..2513574 III 1 NT_166527.1 Title: strong similarity to hypothetical protein AAO51653.1 - Dictyostelium discoideum; uncharacterized protein 2513574 4986426 An12g10730 Aspergillus niger uncharacterized protein XP_001396119.1 2512450 D 5061 CDS An12g10740 4986427 complement(2514918..2515976) III 1 NT_166527.1 Similarity: similarity hypothetical protocatechuate 3,4-dioxygenase beta chain of Streptomyces cover the N-terminal 300 aminoacids.; Title: similarity to hypothetical exported protein YPO0987 - Yersinia pestis; uncharacterized protein 2515976 4986427 An12g10740 Aspergillus niger uncharacterized protein XP_001396120.3 2514918 R 5061 CDS An12g10750 4986428 join(2516679..2516753,2516849..2516952,2517001..2517700,2517749..2518501) III 1 NT_166527.1 Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; uncharacterized protein 2518501 4986428 An12g10750 Aspergillus niger uncharacterized protein XP_001396121.3 2516679 D 5061 CDS An12g10760 84592762 join(2519330..2519563,2519750..2519851,2519935..2520275,2520361..2520526,2520609..2520686,2520914..2521083,2521167..2521245) III 1 NT_166527.1 Title: similarity to hypothetical protein YPL146c -Saccharomyces cerevisiae; uncharacterized protein 2521245 84592762 An12g10760 Aspergillus niger uncharacterized protein XP_059601997.1 2519330 D 5061 CDS An12g10770 84592763 complement(join(2521491..2522422,2522468..2522741,2522772..2523030,2523091..2523218,2523264..2523501,2523578..2523633)) III 1 NT_166527.1 Catalytic activity: aao uses oxygen as an acceptor to produce hydrogen peroxide from primary aromatic or poly-unsaturated aliphatic alcohols.; Pathway: aao is involved in lignin degradation by Pleurotus pulmonarius.; Remark: the purified aao is an extracellular glycoprotein with 14% N-carbohydrate content.; Title: strong similarity to aryl-alcohol oxidase precursor aao - Pleurotus pulmonarius; extracellular/secretion proteins; See PMID 10606774; uncharacterized protein 2523633 84592763 An12g10770 Aspergillus niger uncharacterized protein XP_059601998.1 2521491 R 5061 CDS An12g10780 4986430 complement(join(2525058..2525243,2525353..2525554,2525652..2525934,2525991..2526058,2526117..2526536,2526588..2526627,2526687..2526723,2526777..2526976,2527031..2527145,2527195..2527306,2527441..2527613)) III 1 NT_166527.1 Function: the pathogenicity protein PTH11 functions at the cell cortex as an upstream effector of appressorium differentiation in response to surface cues.; Localization: a PTH11-green fluorescent protein fusion was localized to the cell membrane and vacuoles.; Title: strong similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529; uncharacterized protein 2527613 4986430 An12g10780 Aspergillus niger uncharacterized protein XP_059601999.1 2525058 R 5061 CDS An12g10790 4986432 join(2529797..2529936,2530020..2530144,2530269..2530445,2530509..2530829,2530881..2531055,2531119..2531449) III 1 NT_166527.1 Title: strong similarity to hypothetical oxidase dotB - Mycosphaerella pini; uncharacterized protein 2531449 4986432 An12g10790 Aspergillus niger uncharacterized protein XP_059602000.1 2529797 D 5061 CDS An12g10800 84592764 join(2532960..2533064,2533227..2533275,2533309..2533349) III 1 NT_166527.1 hypothetical protein 2533349 84592764 An12g10800 Aspergillus niger hypothetical protein XP_059602001.1 2532960 D 5061 CDS An12g10810 4986434 join(2533582..2533750,2533835..2534124) III 1 NT_166527.1 Remark: the mRNA sequence of cDNA clone 2678 shows 100 percent identity to the genomic DNA.; Similarity: the ORF encoded protein shows a significant selfblast hit to the hypothetical protein An06g00160 from Aspergillus niger.; Title: strong similarity to EST an_2678 -Aspergillus niger; uncharacterized protein 2534124 4986434 An12g10810 Aspergillus niger uncharacterized protein XP_001396127.1 2533582 D 5061 CDS An12g10820 84592765 complement(2535988..2536428) III 1 NT_166527.1 hypothetical protein 2536428 84592765 An12g10820 Aspergillus niger hypothetical protein XP_059602002.1 2535988 R 5061 CDS An12g10830 4986436 join(2536453..2536471,2536549..2536785,2536842..2536898,2537019..2537569) III 1 NT_166527.1 Induction: mRNA of binA from A. nidulans was induced by bafilomycin.; Remark: the ORF shows also a match with the A. niger EST SEQ ID NO:4020 from patent WO200056762-A2.; Title: similarity to hypothetical protein EAA74834.1 - Gibberella zeae; uncharacterized protein 2537569 4986436 An12g10830 Aspergillus niger uncharacterized protein XP_059602003.1 2536453 D 5061 CDS An12g10840 84592766 complement(2537871..2538521) III 1 NT_166527.1 hypothetical protein 2538521 84592766 An12g10840 Aspergillus niger hypothetical protein XP_059602004.1 2537871 R 5061 CDS An12g10850 4986438 join(2540913..2541164,2541283..2541542,2541583..2541940) III 1 NT_166527.1 Function: macrophomate synthase from the fungus Macrophoma commelinae is a Mg(II)-dependent dimeric enzyme that catalyzes an extraordinary, complex five-step chemical transformation from 2-pyrone and oxalacetate to benzoate involving decarboxylation, C-C bond formation, and dehydration.; Induction: oxalacetate inhibits the enzyme activity at a concentration higher than 5 mM, and magnesium chloride stimulates the enzyme activity.; Title: strong similarity to macrophomate synthase -Macrophoma commelinae; See PMID 10731719; See PMID 10984474; uncharacterized protein 2541940 4986438 An12g10850 Aspergillus niger uncharacterized protein XP_059602005.1 2540913 D 5061 CDS An12g10860 4986439 join(2543241..2543549,2543670..2543883,2543947..2546153,2546224..2546616) III 1 NT_166527.1 Function: lys2 catalyzes both the activation and reduction of alpha-aminoadipic acid to its semialdehyde.; Similarity: lys2 belongs to the superfamily of acyladenylate-forming enzymes.; Title: similarity to aminoadipate reductase enzyme lys2 - Acremonium chrysogenum; See PMID 11254122; uncharacterized protein 2546616 4986439 An12g10860 Aspergillus niger uncharacterized protein XP_059602006.1 2543241 D 5061 CDS An12g10870 4986440 complement(join(2549118..2549214,2549362..2549792)) III 1 NT_166527.1 Title: similarity to hypothetical acetyltransferase 2SCG4.07c - Streptomyces coelicolor; uncharacterized protein 2549792 4986440 An12g10870 Aspergillus niger uncharacterized protein XP_001396133.3 2549118 R 5061 CDS An12g10880 84592767 join(2551592..2551649,2551873..2552016,2552190..2552205,2552306..2552561,2552743..2552900,2552990..2553044) III 1 NT_166527.1 hypothetical protein 2553044 84592767 An12g10880 Aspergillus niger hypothetical protein XP_059602007.1 2551592 D 5061 CDS An12g10890 84592768 complement(join(2553169..2553248,2553354..2553913,2553998..2554032)) III 1 NT_166527.1 Title: weak similarity to dehydrogenase LovC from patent WO200037629-A2 - Aspergillus terreus; uncharacterized protein 2554032 84592768 An12g10890 Aspergillus niger uncharacterized protein XP_059602008.1 2553169 R 5061 CDS An12g10900 84592769 join(2554977..2555178,2555345..2555709) III 1 NT_166527.1 Title: weak similarity to tropinone reductase II TRN2 - Datura stramonium; uncharacterized protein 2555709 84592769 An12g10900 Aspergillus niger uncharacterized protein XP_059602009.1 2554977 D 5061 CDS An12g10910 4986444 join(2556052..2556174,2556244..2556266,2556317..2556433,2556506..2556933,2556970..2557050,2557102..2557247) III 1 NT_166527.1 Function: lovC from A. terreus is essential for formation of 4a,5-dihydromonacolin L.; Title: similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 11386351; See PMID 11412974; uncharacterized protein 2557247 4986444 An12g10910 Aspergillus niger uncharacterized protein XP_059602010.1 2556052 D 5061 CDS An12g10920 84592770 join(2558707..2558763,2558898..2559064,2559095..2559116,2559147..2559374) III 1 NT_166527.1 Title: similarity to protein cognate of protein kinase C-theta from patent WO9714038-A1 - Homo sapiens; uncharacterized protein 2559374 84592770 An12g10920 Aspergillus niger uncharacterized protein XP_059602011.1 2558707 D 5061 CDS An12g10930 84592771 join(2560058..2560362,2560447..2560670,2560745..2560818,2560987..2561124) III 1 NT_166527.1 Title: similarity to hypothetical protein encoded by An12g10570 - Aspergillus niger; uncharacterized protein 2561124 84592771 An12g10930 Aspergillus niger uncharacterized protein XP_059602012.1 2560058 D 5061 CDS An12g10940 84592772 join(2562784..2562789,2563268..2563292,2563589..2563666,2563963..2564000) III 1 NT_166527.1 Title: questionable ORF; uncharacterized protein 2564000 84592772 An12g10940 Aspergillus niger uncharacterized protein XP_059602013.1 2562784 D 5061 CDS An12g10950 4986448 complement(join(2565000..2565292,2565354..2565645)) III 1 NT_166527.1 Title: similarity to guanine nucleotide-specific ribonuclease Po1 - Pleurotus ostreatus; See PMID 7798182; uncharacterized protein 2565645 4986448 An12g10950 Aspergillus niger uncharacterized protein XP_001396141.1 2565000 R 5061 CDS An12g10960 84592773 2566417..>2566731 III 1 NT_166527.1 Remark: C-terminally truncated due to contig border.; Title: strong similarity to hypothetical protein encoded by An03g02680 - Aspergillus niger [truncated ORF]; uncharacterized protein 2566731 84592773 An12g10960 Aspergillus niger uncharacterized protein XP_059602014.1 2566417 D 5061 CDS An15g00010 4987607 complement(join(<1..261,309..444,501..571,662..763,822..953,1011..2003,2064..2114)) III 1 NT_166530.1 Complex: Sec15p of S. cerevisiae and six other proteins (Sec6p, Sec8p, Sec3p, Sec5p, Sec10p and Exo70p) together form the exocyst complex.; Function: Sec15p of S. cerevisiae and six other proteins (Sec6p, Sec8p, Sec3p, Sec5p, Sec10p and Exo70p) function together in a complex (exocyst) required for exocytosis, and not other intracellular trafficking steps.; Localization: the exocyst of S. cerevisiae is specifically located at sites of vesicle fusion at the tip of the bud.; Remark: C-terminally truncated ORF due to end of contig.; Title: strong similarity to exocyst complex vesicular traffic control protein Sec15 - Saccharomyces cerevisiae [truncated ORF]; plasma membrane; See PMID 10873817; See PMID 8978675; uncharacterized protein 2114 4987607 An15g00010 Aspergillus niger uncharacterized protein XP_059602396.1 1 R 5061 CDS An15g00020 4987632 join(3793..3983,4016..4424,4521..4955,5012..5377,5436..5471,5539..5605,5692..5780,5828..5845,5895..5940,5978..6070,6202..6321,6377..6597) III 1 NT_166530.1 Complex: Mei2p of S. pombe also binds to the novel WD-repeat protein Mip1p, which facilitates function of the meiotic regulator Mei2p.; Complex: Mei2p of S. pombe binds to a polyadenylated RNA molecule, meiRNA, loss of which blocks meiosis I.; Function: mei2 of S. pombe is required also for meiosis I.; Function: mei2 of S. pombe, which is essential but not sufficient for the initiation of premeiotic DNA synthesis, encodes an RNA-binding protein.; Localization: binding of Mei2p of S. pombe to mRNA is necessary for nuclear localization of Mei2p.; Repression: the expression of mei2 of S. pombe is negatively regulated by cAMP.; Title: similarity to meiotic RNA-binding protein mei2p - Schizosaccharomyces pombe; See PMID 2840284; See PMID 7520368; See PMID 9778252; uncharacterized protein 6597 4987632 An15g00020 Aspergillus niger uncharacterized protein XP_059602397.1 3793 D 5061 CDS An15g00025 84593076 7721..7960 III 1 NT_166530.1 Title: strong similarity to hypothetical protein EAA57835.1 - Aspergillus nidulans; uncharacterized protein 7960 84593076 An15g00025 Aspergillus niger uncharacterized protein XP_059602398.1 7721 D 5061 CDS An15g00030 4987619 complement(join(8003..8127,8302..8469,8625..9149,9617..10216,10282..10652,10708..10835,10900..11239,11346..11545)) III 1 NT_166530.1 Function: Las21p of S. cerevisiae participates in extracellular/cell surface phenomena.; Function: the major facilitator super family is the largest family of secondary transport carriers and each newly identified family has been shown to exhibit specificity for a single class of substrates.; Remark: Las21 is a synonymous name for Yj1062W.; Remark: the N-terminal of An15g00030 shows high similarity to regions conserved in many phosphodiesterases and nucleotide pyrophosphatases as shown by alignment with Pig-o - Mus musculus.; Similarity: Las21 (Yj1062W) of S. cerevisiae is a member of the major facilitator super family, possessing multimembrane spanning domains.; Title: strong similarity to member of the major facilitator superfamily Las21 - Saccharomyces cerevisiae; plasma membrane; See PMID 10734606; See PMID 10781593; See PMID 10943556; uncharacterized protein 11545 4987619 An15g00030 Aspergillus niger uncharacterized protein XP_059602399.1 8003 R 5061 CDS An15g00040 4987636 complement(join(11697..11733,11830..12070,12242..12328,12419..12466,12525..12705)) III 1 NT_166530.1 Remark: N-terminal half shows similarity to YBL028c of S. cerevisiae; S. cerevisiae YBL028c is 100 aa shorter.; Remark: YBL028c of S. cerevisiae has been classified as mating type regulating protein by the MIPS database,but no supporting literature was found.; Title: similarity to hypothetical protein YBL028c -Saccharomyces cerevisiae; uncharacterized protein 12705 4987636 An15g00040 Aspergillus niger uncharacterized protein XP_059602400.1 11697 R 5061 CDS An15g00050 4987605 join(13268..13415,13510..13855,13938..14232,14330..14435,14485..14710,14769..15279) III 1 NT_166530.1 Function: SIZ1 of S. cerevisiae is required for septin-sumoylation where together with the SUMO1/Smt3-ligase it acts as an adaptor between the conjugating enzyme and substrates.; Remark: SIZ1 of S. cerevisiae is also known as YDR409W.; Remark: the function of SIZ1 in S. cerrevisiae may contribute to the regulation of chromatin structure and chromosome maintenance.; Similarity: SIZ1 of S. cerevisiae is a member of the PIAS family that contain a zinc-binding RING domain.; Title: strong similarity to an E3-like factor Siz1 -Saccharomyces cerevisiae; See PMID 11333221; See PMID 11572779; See PMID 11577116; See PMID 11587849; uncharacterized protein 15279 4987605 An15g00050 Aspergillus niger uncharacterized protein XP_059602401.1 13268 D 5061 CDS An15g00060 4987611 join(15802..16031,16200..16317,16404..16493,16570..16701) III 1 NT_166530.1 Complex: TRAPP (transport protein particle) of S. cereviesiae is a multiprotein complex containing ten subunits, Bet5p, Trs20p, Bet3p, Trs23p, Trs33p,Trs31p,Trs65p, Trs85p, Trs120p and Trs130p.; Function: targeting of ER vesicles to Golgi.; Golgi; Remark: Trs33p of S. cerevisiae is N-terminally 50 AA longer.; Remark: Trs33p of S. cerevisiae is a 33 kDa subunit of TRAPP.; Remark: the systematic name for Trs33p of S. cerevisiae is YOR115c.; Title: strong similarity to TRAPP complex subunit involved in targeting and fusion of ER transport vesicles to golgi Trs33 - Saccharomyces cerevisiae; See PMID 10698928; uncharacterized protein 16701 4987611 An15g00060 Aspergillus niger uncharacterized protein XP_001396545.1 15802 D 5061 CDS An15g00070 4987622 complement(join(17160..17300,17360..17504,17558..17642,17698..18075,18136..18223,18296..18406,18509..18540,18629..18641)) III 1 NT_166530.1 Catalytic activity: (S)-malate + NAD(+) <=> oxaloacetate + NADH, and also oxidizes some other 2-hydroxydicarboxylic acids.; Function: malat-dehydrogenase catalyzes the conversion of oxaloacetate and malate.; Localization: normally mitochondrial, but some plant isoforms are localized in the glyoxisome.; Similarity: shows also strong similarity to cytosolic mdh from Piromyces sp. E2.; Title: strong similarity to malate dehydrogenase precursor MDH - Mus musculus; localisation:mitochondrion; See PMID 9834842; uncharacterized protein 18641 4987622 An15g00070 Aspergillus niger uncharacterized protein XP_003188908.1 17160 R 5061 CDS An15g00080 4987625 complement(join(20176..20350,20430..20554,20626..20649,20713..20807,20918..20960)) III 1 NT_166530.1 Complex: L28 of R. norvegicus is a component of the 60S fragment of the ribosome.; Function: the ribosome translates mRNA into protein.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L28 - Rattus norvegicus; cytoplasm; See PMID 2207170; uncharacterized protein 20960 4987625 An15g00080 Aspergillus niger uncharacterized protein XP_001396547.1 20176 R 5061 CDS An15g00090 4987614 join(21509..21563,21631..21950) III 1 NT_166530.1 Title: similarity to hypothetical protein SPAC1687.07 - Schizosaccharomyces pombe; uncharacterized protein 21950 4987614 An15g00090 Aspergillus niger uncharacterized protein XP_001396548.1 21509 D 5061 CDS An15g00100 4987612 complement(join(22612..23271,23352..23727,23797..23816)) III 1 NT_166530.1 Complex: in addition to the RNA-binding activity of the human SAP 49, this protein is associated specifically with U2 snRNP and the U2 snRNP-associated spliceosomal protein SAP 145.; Function: SAP 49 of H. sapiens is associated specifically with U2 snRNP and binds to a region in the pre-mRNA immediately upstream of the branchpoint sequence in the prespliceosomal complex A.; Title: strong similarity to splicosome associated protein SAP49 - Homo sapiens; nucleus; See PMID 7958871; uncharacterized protein 23816 4987612 An15g00100 Aspergillus niger uncharacterized protein XP_001396549.1 22612 R 5061 CDS An15g00110 4987608 join(25261..25378,25494..25739,25856..26115,26182..26472) III 1 NT_166530.1 Function: FLX1 from S. cerevisiae is involved in maintaining the balance of flavin nucleotides in mitochondria.; Function: FLXI from S. cerevisiae is a flavin adenine dinucleotide transporter, maintaining a normal ratio of FAD/FMN in mitochondria.; Localization: FLXI from S. cerevisiae is localized to the inner membrane of mitochondria.; Title: strong similarity to mitochondrial FAD carrier protein Flx1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8631763; uncharacterized protein 26472 4987608 An15g00110 Aspergillus niger uncharacterized protein XP_059602402.1 25261 D 5061 CDS An15g00120 4987627 complement(join(27007..27357,27425..27598,27698..27751,27814..28578)) III 1 NT_166530.1 Function: WT1 from H. sapiens recognises and binds to the DNA sequence 5'-CGCCCCCGC-3'.; Function: WT1 proteins from H. sapiens act as nucleic acid-binding zinc finger-containing transcription factors involved in both transactivation and -repression.; Remark: proteins from data banks are N-terminally longer (approx. 100 AA).; Similarity: shows similarity to various Zn-finger proteins but strongest similarity to WT1 - H. sapiens.; Title: similarity to Wilms tumor susceptibility protein WT1 - Homo sapiens; See PMID 10333728; uncharacterized protein 28578 4987627 An15g00120 Aspergillus niger uncharacterized protein XP_001396551.1 27007 R 5061 CDS An15g00130 84593077 complement(join(30638..30662,30797..30839,31250..31296,31419..31543,31876..31984,32041..32048)) III 1 NT_166530.1 Remark: shows weak similarity to N-terminal half of cytidylate kinase CP0181 Chlamydophila pneumoniae.; Title: questionable ORF; uncharacterized protein 32048 84593077 An15g00130 Aspergillus niger uncharacterized protein XP_059602403.1 30638 R 5061 CDS An15g00140 4987601 complement(join(37514..37538,37636..37711,37785..37917,37985..38455,38565..39100,39173..39501,39571..39652,39890..39989)) III 1 NT_166530.1 Complex: in S. cerevisiae Tup1 forms a complex with Ssn6 and Histone H3 and H4.; Function: Tup1 from S. cerevisiae interacts directly with histones H3 and H4 to act as general repressor of transcription.; Function: the Ssn6-Tup1 complex from S. cerevisiae likely actively recruits deacetylase activities to deacetylate adjacent nucleosomes and promote Tup1-histone interaction.; Similarity: Roc1 from Candida albicans and TupA from Aspergillus nidulans also show strong similarity.; Title: similarity to transcription repressor Tup1 -Saccharomyces cerevisiae; nucleus; See PMID 10871883; See PMID 11069890; uncharacterized protein 39989 4987601 An15g00140 Aspergillus niger uncharacterized protein XP_001396553.3 37514 R 5061 CDS An15g00150 4987615 join(41195..41463,41560..42349) III 1 NT_166530.1 Function: this enzyme introduces a C-5 double bond in the B ring of ergosterol.; Remark: the C5-sterol desaturase is required for ergosterol biosynthesis in yeast.; Title: strong similarity to C-5 sterol desaturase Erg3 - Saccharomyces cerevisiae; See PMID 1864507; See PMID 10514567; See PMID 10933640; uncharacterized protein 42349 4987615 An15g00150 Aspergillus niger uncharacterized protein XP_001396554.1 41195 D 5061 CDS An15g00160 4987633 complement(join(43083..43972,44077..44258,44312..45258,45323..45590,45678..45784,45856..45947,46100..46163)) III 1 NT_166530.1 Remark: GCR3 is involved in the expression of glycolytic genes.; Title: strong similarity to transcription regulator CaGCR3 - Candida albicans; See PMID 10206191; uncharacterized protein 46163 4987633 An15g00160 Aspergillus niger uncharacterized protein XP_001396555.1 43083 R 5061 CDS An15g00170 4987617 complement(join(47808..47941,48008..48212,48266..48459,48515..48863,48992..49075,49133..49305,49395..49440)) III 1 NT_166530.1 Function: Schizosaccharomyces pombe skp1+ encodes a protein kinase related to mammalian glycogen synthase kinase 3.; Function: glycogen synthase kinase 3 (GSK-3) family is involved in cell fate determination, nuclear signalling,and hormonal regulation in higher eukaryotes.; Title: strong similarity to protein kinase skp1p -Schizosaccharomyces pombe; See PMID 8524294; See PMID 9064503; uncharacterized protein 49440 4987617 An15g00170 Aspergillus niger uncharacterized protein XP_001396556.1 47808 R 5061 CDS An15g00180 84593078 complement(join(54614..54729,54798..54834,54937..54994,55393..55454)) III 1 NT_166530.1 hypothetical protein 55454 84593078 An15g00180 Aspergillus niger hypothetical protein XP_059602404.1 54614 R 5061 CDS An15g00190 4987624 complement(join(59348..59455,59529..60173,60252..60563)) III 1 NT_166530.1 Title: strong similarity to mitochondrial import receptor MOM38 - Neurospora crassa; localisation:mitochondrion; uncharacterized protein 60563 4987624 An15g00190 Aspergillus niger uncharacterized protein XP_001396558.1 59348 R 5061 CDS An15g00200 4987600 join(61614..61627,61762..61950,62009..62044,62106..62203,62308..62477,62541..62621,62677..62784,62836..62955,63027..63401,63462..63638,63698..63937) III 1 NT_166530.1 Remark: the H. sapiens PFKFB4 product encodes bifunctional enzyme 6-Phosphofructo-2-kinase/fructose 2,6-bisphosphatase (PFK-2/FBPase-2), responsible for the synthesis and breakdown of Fru-2,6-P2, a key metabolite in the regulation of glycolysis.; Title: similarity to 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase PFKFB4 - Homo sapiens; See PMID 10095107; uncharacterized protein 63937 4987600 An15g00200 Aspergillus niger uncharacterized protein XP_001396559.1 61614 D 5061 CDS An15g00210 4987618 join(64872..65000,65086..67377) III 1 NT_166530.1 Remark: the systematic genename of ELP2 is YGR200C.; Title: strong similarity to elongator complex and elongating RNA pol II holoenzyme 90 kDa subunit Elp2 -Saccharomyces cerevisiae; See PMID 10777588; uncharacterized protein 67377 4987618 An15g00210 Aspergillus niger uncharacterized protein XP_001396560.1 64872 D 5061 CDS An15g00220 4987634 complement(join(67690..68402,68466..68598)) III 1 NT_166530.1 Remark: the homologe S. pombe SPAC20G4. 01 protein sequence is fragmented (see database entry).; Title: strong similarity to hypothetical ATP-dependent transporter SPAC20G4.01 - Schizosaccharomyces pombe; uncharacterized protein 68598 4987634 An15g00220 Aspergillus niger uncharacterized protein XP_001396561.1 67690 R 5061 CDS An15g00230 4987628 join(69014..69112,69191..70582) III 1 NT_166530.1 Catalytic activity: tRNA isopentenyltransferases catalyze the conversion of isopentenyl diphosphate + tRNA = diphosphate + tRNA containing 6-isopentenyladenosine.; Title: strong similarity to tRNA isopentenyltransferase Mod5 - Saccharomyces cerevisiae; uncharacterized protein 70582 4987628 An15g00230 Aspergillus niger uncharacterized protein XP_001396562.1 69014 D 5061 CDS An15g00240 4987629 complement(join(71155..71300,71369..71668,71751..71921,71971..72074,72131..72138,72189..72216,72270..72301,72370..72612,72670..72744)) III 1 NT_166530.1 Function: Rai1p (Rat1p interacting protein 1) of S. cerevisisae is required for normal 5. 8S rRNA processing.; Function: S. cerevisisae rai1 deletion mutant indicated a defect in 60S rRNA biogenesis.; Remark: the systematic genename of RAI1 of S. cerevisiae is YGL246c.; Title: strong similarity to nuclear exoribonuclease binding protein Rai1 - Saccharomyces cerevisiae; See PMID 10805743; uncharacterized protein 72744 4987629 An15g00240 Aspergillus niger uncharacterized protein XP_001396563.1 71155 R 5061 CDS An15g00250 4987602 join(73280..73323,73425..73681,73789..73941,74000..74595) III 1 NT_166530.1 Title: strong similarity to hypothetical protein YOR164c - Saccharomyces cerevisiae; uncharacterized protein 74595 4987602 An15g00250 Aspergillus niger uncharacterized protein XP_001396564.1 73280 D 5061 CDS An15g00260 4987610 complement(join(74695..74792,74977..75331)) III 1 NT_166530.1 hypothetical protein 75331 4987610 An15g00260 Aspergillus niger hypothetical protein XP_059602405.1 74695 R 5061 CDS An15g00270 4987613 join(76033..76121,76193..76413,76473..76572,76628..77050,77113..77338) III 1 NT_166530.1 Complex: human replication factor C is a heteropentamer of subunits of 140/145, 40, 38, 37, and 36. 5 kD that forms a complex with proliferating cell nuclear antigen (PCNA) in the presence of ATP.; Function: the 40 kd subunit of human replication factor C binds ATP. replication factor C and PCNA are necessary for the elongation of primed DNA templates by DNA polymerase delta and epsilon.; Similarity: the predicted A. niger protein shows strong similarity to human 40 kD subunit of replication factor C (RFC2), which is also known as activator 1.; Title: strong similarity to 40 kD subunit of replication factor C RFC2 - Homo sapiens; nucleus; uncharacterized protein 77338 4987613 An15g00270 Aspergillus niger uncharacterized protein XP_001396566.1 76033 D 5061 CDS An15g00280 4987621 complement(join(77572..77707,77770..77873,77940..78517,78650..78755)) III 1 NT_166530.1 Title: strong similarity to hypothetical protein jhp0295 - Helicobacter pylori; uncharacterized protein 78755 4987621 An15g00280 Aspergillus niger uncharacterized protein XP_001396567.1 77572 R 5061 CDS An15g00290 4987620 complement(join(79400..80287,80350..80531,80597..80873,80935..80956,81026..81279)) III 1 NT_166530.1 Catalytic activity: A monocarboxylic acid amide + H(2)O = a monocarboxylate + NH(3).; Title: strong similarity to acetamidase amdS -Aspergillus nidulans; See PMID 6769897; uncharacterized protein 81279 4987620 An15g00290 Aspergillus niger uncharacterized protein XP_059602406.1 79400 R 5061 CDS An15g00300 4987609 join(82250..82346,82598..83738,83797..84394,84443..84718) III 1 NT_166530.1 Function: the Aspergillus oryzae amyR protein binds to DNA as a homodimer, which is responsible for starch/maltose induction of amylolytic genes.; Remark: similarity corresponds only to central region of homologous protein.; Title: similarity to transcription regulator of maltose utilization amyR - Aspergillus oryzae; See PMID 10830498; uncharacterized protein 84718 4987609 An15g00300 Aspergillus niger uncharacterized protein XP_059602407.1 82250 D 5061 CDS An15g00310 4987630 complement(join(85028..86104,86158..86454,86524..86736)) III 1 NT_166530.1 Title: strong similarity to monosaccharide transporter AmMst-1 - Amanita muscaria; plasma membrane; See PMID 9487692; uncharacterized protein 86736 4987630 An15g00310 Aspergillus niger uncharacterized protein XP_001396570.1 85028 R 5061 CDS An15g00320 4987604 join(87666..89067,89134..89585) III 1 NT_166530.1 Catalytic activity: hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranoside.; Remark: the purified A. niger enzyme hydrolyses sucrose and raffinose but there was no detectable hydrolysis of inulin, melezitose or PNPG.; Title: strong similarity to beta-fructofuranosidase precursor suc1 - Aspergillus niger; uncharacterized protein 89585 4987604 An15g00320 Aspergillus niger uncharacterized protein XP_059602408.1 87666 D 5061 CDS An15g00330 4987599 complement(join(90226..91017,91073..91714)) III 1 NT_166530.1 Title: strong similarity to glycoprotein-associated amino acid transporter b0,+AT1 - Mus musculus; plasma membrane; See PMID 8631857; See PMID 10588648; uncharacterized protein 91714 4987599 An15g00330 Aspergillus niger uncharacterized protein XP_001396572.3 90226 R 5061 CDS An15g00340 4987616 92475..93635 III 1 NT_166530.1 Function: protein involved in import of cytochrome c into mitochondria in yeast.; Title: similarity to mitochondrial import factor of cytochrome c Cyc2 - Saccharomyces cerevisiae; uncharacterized protein 93635 4987616 An15g00340 Aspergillus niger uncharacterized protein XP_001396573.1 92475 D 5061 CDS An15g00350 4987626 93891..96200 III 1 NT_166530.1 Catalytic activity: 2-Hydroxybutane-1,2,4-tricarboxylate = But-1-ene-1,2,4-tricarboxylate + H2O.; Function: responsible for the dehydration of cis-homoaconitate to homoisocitrate acid.; Pathway: third step in lysine biosynthesis.; Title: strong similarity to homoaconitate hydratase lYSF - Aspergillus nidulans; localisation:mitochondrion; uncharacterized protein 96200 4987626 An15g00350 Aspergillus niger uncharacterized protein XP_001396574.1 93891 D 5061 CDS An15g00360 4987603 join(97005..97450,97511..100280) III 1 NT_166530.1 Remark: similarity corresonds only to the N-terminal region, which binds integral membrane proteins. The acidic C-terminal 'regulatory' domain contains an alternatively spliced sequence.; Title: similarity to ankyrin ANK1 - Homo sapiens; See PMID 2137557; uncharacterized protein 100280 4987603 An15g00360 Aspergillus niger uncharacterized protein XP_059602409.1 97005 D 5061 CDS An15g00370 84593079 join(100626..100795,100864..100926,100993..101134) III 1 NT_166530.1 hypothetical protein 101134 84593079 An15g00370 Aspergillus niger hypothetical protein XP_059602410.1 100626 D 5061 CDS An15g00380 84593080 complement(join(101964..103544,103630..103896)) III 1 NT_166530.1 Function: MSS1 of S. cerevisiae works in association with the small subunit of mitoribosomes and seems to play some part in mitochondrial translation.; Title: strong similarity to mitochondrial GTPase Mss1 - Saccharomyces cerevisiae; See PMID 8392589; See PMID 9774408; uncharacterized protein 103896 84593080 An15g00380 Aspergillus niger uncharacterized protein XP_059602411.1 101964 R 5061 CDS An15g00390 4987637 complement(join(104732..105565,105622..110223)) III 1 NT_166530.1 Function: sepA function in A. nidulans requires a preceding mitosis; sepA acts prior to actin ring formation during septation in A. nidulans.; Remark: the A. nidulans sepA gene encodes a member of the FH1/2 protein family, which appear to have roles in morphogenesis and cytokinesis in yeast and Drosophila.; Title: strong similarity to cytokinesis protein sepA - Aspergillus nidulans; See PMID 8150280; uncharacterized protein 110223 4987637 An15g00390 Aspergillus niger uncharacterized protein XP_001396578.3 104732 R 5061 CDS An15g00400 4987638 join(111094..111120,111183..111599) III 1 NT_166530.1 Title: similarity to hypothetical protein CAD70967.1 - Neurospora crassa; uncharacterized protein 111599 4987638 An15g00400 Aspergillus niger uncharacterized protein XP_001396579.1 111094 D 5061 CDS An15g00410 4987640 complement(join(112630..113521,113611..113786,113853..113867)) III 1 NT_166530.1 Function: insertional inactivation of A. nidulans aciA did not reveal an altered phenotype. Acetate inducibility of aciA was found to be dependent on the amdA regulatory gene.; Remark: strong similarity also to formate dehydrogenases (EC 1. 2. 1. 2).; Title: strong similarity to acetate-inducible gene aciA - Aspergillus nidulans; See PMID 3916805; uncharacterized protein 113867 4987640 An15g00410 Aspergillus niger uncharacterized protein XP_001396580.3 112630 R 5061 CDS An15g00420 4987641 complement(join(116603..118906,118963..119103,119171..119695)) III 1 NT_166530.1 Catalytic activity: ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).; Title: strong similarity to mitochondrial leucine--tRNA ligase leu-5 - Neurospora crassa; localisation:mitochondrion; See PMID 4940374; uncharacterized protein 119695 4987641 An15g00420 Aspergillus niger uncharacterized protein XP_001396581.1 116603 R 5061 CDS An15g00430 84593081 join(120103..120128,120297..120361,120440..120522) III 1 NT_166530.1 Title: questionable ORF; uncharacterized protein 120522 84593081 An15g00430 Aspergillus niger uncharacterized protein XP_059602412.1 120103 D 5061 CDS An15g00440 4987643 join(123855..125721,125783..125979,126033..126071) III 1 NT_166530.1 Remark: homology corresponds to multiple serine repeats.; hypothetical protein 126071 4987643 An15g00440 Aspergillus niger hypothetical protein XP_001396583.1 123855 D 5061 CDS An15g00450 4987644 complement(join(127226..127707,127765..128883,129082..129103)) III 1 NT_166530.1 Title: strong similarity to hypothetical protein SPBC16A3.10 - Schizosaccharomyces pombe; uncharacterized protein 129103 4987644 An15g00450 Aspergillus niger uncharacterized protein XP_059602413.1 127226 R 5061 CDS An15g00460 4987645 join(129529..129570,129625..129654,129717..130742,130815..131453) III 1 NT_166530.1 Function: h1Vps45 is believed to be implicated in vesicular transportation from Golgi to vacuole.; Function: the protein is necessary for the correct sorting and delivery of vacuolar hydrolases.; Title: strong similarity to vacuolar protein sorting protein hlVps45 - Homo sapiens; See PMID 10404641; uncharacterized protein 131453 4987645 An15g00460 Aspergillus niger uncharacterized protein XP_059602414.1 129529 D 5061 CDS An15g00470 4987646 complement(join(132191..135475,135528..136511)) III 1 NT_166530.1 Function: in A. nidulans the hypA gene is required for multiple aspects of hyphal morphogenesis.; Remark: hyp mutants have aberrant patterns of septation and show defects in polarity establishment and tip growth in A. nidulans.; Title: strong similarity to hypercellular protein hypA - Aspergillus nidulans; See PMID 10049919; uncharacterized protein 136511 4987646 An15g00470 Aspergillus niger uncharacterized protein XP_001396586.3 132191 R 5061 CDS An15g00480 4987647 join(137531..137658,137719..142737,142808..142892) III 1 NT_166530.1 Title: strong similarity to hypothetical protein 99H12.140 - Neurospora crassa; uncharacterized protein 142892 4987647 An15g00480 Aspergillus niger uncharacterized protein XP_059602415.1 137531 D 5061 CDS An15g00490 4987648 join(143219..143243,143375..143736,143811..144326) III 1 NT_166530.1 Complex: The Mediator complex is composed of two subcomplexes, the Rgr1 and Srb4 subcomplexes, which appear to function in the reception of activator signals and the subsequent modulation of Pol II activity, respectively; Complex: the Med6-containing subcomplex is composed of: Srb4p, Srb2p, Srb5p, Srb6p, Med6p, Rox3p.; Complex: the Rgr1-associated subcomplex is composed of : Rgr1p, Gal11p, Sin4p, Med3p, Srb7p, Med1p, Med4p,Med7p, Med8p, Med9p.; Function: Med6p of S. cerevisiae is subunit of the multisubunit Mediator complex which is required for most RNA polymerase II (Pol II) transcription.; Remark: the systematic genename of MED6 is YHR058C.; Title: strong similarity to RNA pol II transcription mediator Med6 - Saccharomyces cerevisiae; See PMID 9234719; See PMID 9671455; See PMID 9710620; See PMID 9891034; uncharacterized protein 144326 4987648 An15g00490 Aspergillus niger uncharacterized protein XP_059602416.1 143219 D 5061 CDS An15g00500 4987649 join(144872..144915,145033..145228,145295..145762) III 1 NT_166530.1 Title: strong similarity to hypothetical protein YJL055w - Saccharomyces cerevisiae; uncharacterized protein 145762 4987649 An15g00500 Aspergillus niger uncharacterized protein XP_059602417.1 144872 D 5061 CDS An15g00510 4987650 complement(join(145917..146555,146628..146739,146827..146864)) III 1 NT_166530.1 Catalytic activity: the proteasome has an ATP-dependent proteolytic activity.; Function: the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph.; Pathway: is involved in an atp/ubiquitin-dependent non-lysosomal proteolytic pathway.; Title: strong similarity to proteasome 20S subunit C2 - Rattus norvegicus; See PMID 2335242; See PMID 2819072; uncharacterized protein 146864 4987650 An15g00510 Aspergillus niger uncharacterized protein XP_001396590.1 145917 R 5061 CDS An15g00520 4987651 join(147377..147415,147495..147708,147864..147997) III 1 NT_166530.1 Title: strong similarity to hypothetical membrane protein YJR044c - Saccharomyces cerevisiae; uncharacterized protein 147997 4987651 An15g00520 Aspergillus niger uncharacterized protein XP_001396591.1 147377 D 5061 CDS An15g00530 4987652 join(148368..148428,148492..148563,148617..149935) III 1 NT_166530.1 hypothetical protein 149935 4987652 An15g00530 Aspergillus niger hypothetical protein XP_001396592.3 148368 D 5061 CDS An15g00540 4987653 join(150365..150463,150527..150787,150896..150993,151056..151119) III 1 NT_166530.1 Title: strong similarity to hypothetical protein B13O20.120 - Neurospora crassa; uncharacterized protein 151119 4987653 An15g00540 Aspergillus niger uncharacterized protein XP_001396593.1 150365 D 5061 CDS An15g00550 4987654 complement(join(151848..151958,152043..152150,152177..152404,152478..152894)) III 1 NT_166530.1 Title: strong similarity to hypothetical protein YBR101c - Saccharomyces cerevisiae; uncharacterized protein 152894 4987654 An15g00550 Aspergillus niger uncharacterized protein XP_001396594.3 151848 R 5061 CDS An15g00560 4987655 join(155508..155514,155642..155672,155930..155985,156173..156203,156278..157049,157112..157342) III 1 NT_166530.1 Title: strong similarity to actin gamma -Aspergillus nidulans; cytoskeleton; See PMID 2975248; uncharacterized protein 157342 4987655 An15g00560 Aspergillus niger uncharacterized protein XP_003188912.1 155508 D 5061 CDS An15g00570 4987656 complement(join(158794..160412,160475..161002,161073..161352)) III 1 NT_166530.1 Catalytic activity: the AIRS part of S. pombe ADE1 converts 1-(5-phospho-D-ribosyl)acetamidine to ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.; Catalytic activity: the GARS part of S. pombe ADE1 converts ATP + 5-phospho-D-ribosylamine + glycine to ADP + phosphate + N 1-(5-phospho-D-ribosyl)glycinamide.; Function: S. pombe ADE1 has glycinamide ribotide synthetase (GARSase) and aminoimidazole ribotide synthetase (AIRSase) enzyme activities which catalyse the 2nd and 5th steps, respectively, of the purine synthetic pathway. ATP + 2-(formamido)-N; Title: strong similarity to bifunctional purine synthase ade1p - Schizosaccharomyces pombe; See PMID 3502942; uncharacterized protein 161352 4987656 An15g00570 Aspergillus niger uncharacterized protein XP_001396596.1 158794 R 5061 CDS An15g00580 4987657 join(162358..162546,162637..163060,163120..163183,163254..164844) III 1 NT_166530.1 Function: Overexpression of PET127 completely blocked respiratory growth and caused cells to lose wild-type mitochondrial DNA, suggesting that too much Pet127p prevents mitochondrial gene expression.; Function: S. cerevisiae Pet127 is membrane bound and is involved in processing of the 5' ends of mitochondrial mRNAs.; Similarity: similarity is from the central region of the prediced A. niger protein to the N-terminal half of S. cerevisiae Pet127.; Title: strong similarity to mitochondrial mRNA processing protein Pet127 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 10397341; See PMID 9111353; uncharacterized protein 164844 4987657 An15g00580 Aspergillus niger uncharacterized protein XP_059602418.1 162358 D 5061 CDS An15g00590 4987658 complement(166182..170114) III 1 NT_166530.1 Function: human Nod2 is required for LPS-induced NF-kB activation and might be a cytosolic receptor for pathogen components.; Title: weak similarity to NOD2 - Homo sapiens; See PMID 11058605; uncharacterized protein 170114 4987658 An15g00590 Aspergillus niger uncharacterized protein XP_001396598.1 166182 R 5061 CDS An15g00600 4987659 complement(join(172562..172765,173085..173173,173400..173491,173587..173960,174056..174148)) III 1 NT_166530.1 Title: weak similarity to hypothetical protein CAD11363.1 - Neurospora crassa; uncharacterized protein 174148 4987659 An15g00600 Aspergillus niger uncharacterized protein XP_001396599.3 172562 R 5061 CDS An15g00610 4987660 join(174621..174939,175022..175413,175452..175475) III 1 NT_166530.1 Catalytic activity: imidazoleglycerolphosphate dehydratases convert D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O.; Function: imidazoleglycerolphosphate dehydratases are required for histidine biosynthesis.; Regulation: expression of the igh gene in T. harzianum is not inhibited by external histidine and the level of igh mRNA was about threefold higher in cells starved of histidine.; Title: strong similarity to imidazoleglycerolphosphate dehydratase igh - Trichoderma harzianum; See PMID 1406594; uncharacterized protein 175475 4987660 An15g00610 Aspergillus niger uncharacterized protein XP_059602419.1 174621 D 5061 CDS An15g00620 4987661 complement(join(175565..175878,175945..176239)) III 1 NT_166530.1 hypothetical protein 176239 4987661 An15g00620 Aspergillus niger hypothetical protein XP_001396601.3 175565 R 5061 CDS An15g00630 4987662 complement(join(177395..178039,178092..178247,178317..178595)) III 1 NT_166530.1 Function: S. cerevisiae SUR1 is required for the mannosylation of inositolphosphorylceramide (IPC) to form mannosylinositolphosphorylceramide (MIPC).; Title: strong similarity to sphingolipid metabolism Sur1 - Saccharomyces cerevisiae; See PMID 9323360; uncharacterized protein 178595 4987662 An15g00630 Aspergillus niger uncharacterized protein XP_001396602.1 177395 R 5061 CDS An15g00640 4987663 complement(join(185144..185695,185764..185952)) III 1 NT_166530.1 Title: strong similarity to hypothetical protein GABA-A receptor epsilon subunit - Caenorhabditis elegans; uncharacterized protein 185952 4987663 An15g00640 Aspergillus niger uncharacterized protein XP_001396603.1 185144 R 5061 CDS An15g00650 84593082 186898..187266 III 1 NT_166530.1 Function: replacement histone H3. 2 genes of M. sativa may affect nucleosome assembly and chromatin repression.; Title: strong similarity to replacement histone H3.2 - Medicago sativa; nucleus; See PMID 8722568; uncharacterized protein 187266 84593082 An15g00650 Aspergillus niger uncharacterized protein XP_059602420.1 186898 D 5061 CDS An15g00660 4987665 complement(join(188235..189076,189160..189800,189849..189964,190029..190046,190100..190210,190289..191300,191479..191656,191852..193052)) III 1 NT_166530.1 Remark: the N-terminal 400 aa of the predicted A. niger protein show no similarity to other proteins, aa 400 to 800 show similarity to proline rich proteins and the remaining C-terminal region shows similarity to two hypothetical proteins from N. crassa and S. pombe respectevly.; Remark: the predicted A. niger protein potentially is N-terminally 800 aa too long.; Title: strong similarity to hypothetical protein 65E11.60 - Neurospora crassa; uncharacterized protein 193052 4987665 An15g00660 Aspergillus niger uncharacterized protein XP_059602421.1 188235 R 5061 CDS An15g00670 4987666 join(194032..194814,194865..195025,195080..195160,195220..195343,195392..195520,195570..195755) III 1 NT_166530.1 Remark: information regarding S. cerevisiae EHT1 has not been published and is available from http://genome-www. stanford. edu/cgi-bin/SGD/genehunter.; Remark: the systematic name for S. cerevisiae EHT1 is YBR177c.; Title: strong similarity to alcohol acyl transferase Eht1 - Saccharomyces cerevisiae; uncharacterized protein 195755 4987666 An15g00670 Aspergillus niger uncharacterized protein XP_001396606.1 194032 D 5061 CDS An15g00680 4987667 complement(join(195933..196064,196148..196297,196364..196651)) III 1 NT_166530.1 Function: S. cerevisiae Loc1p is a double-stranded RNA-binding protein and is involved in localization of mRNA.; Function: S. cerevisiae Loc1p is required for the localization of transcriptional repressor ASH1 mRNA to the distal end of daughter cells during anaphase of the cell cycle.; Localization: by immunofluorescence S. cerevisiae Loc1p was observed to be a nuclear protein that did not shuttle between the nucleus and cytoplasm.; Remark: information regarding S. cerevisiae Loc1 has not been published and is available from http://www. ncbi. nlm. nih. gov/cgi-bin/Entrez/coglist?gi=34&cog=-,http://genome-www. stanford. edu/cgi-bin/SGD/genehunter and http://www. google. de/search?q=cache:www. wisc. edu/union/info/conf/rna/RNA2000_poster. pdf+loc1+cerevisiae&hl=de.; Title: strong similarity to RNA-binding protein Loc1 - Saccharomyces cerevisiae; nucleus; uncharacterized protein 196651 4987667 An15g00680 Aspergillus niger uncharacterized protein XP_001396607.1 195933 R 5061 CDS An15g00690 4987668 join(197109..197151,197264..197325,197540..197686,197804..197923) III 1 NT_166530.1 Title: strong similarity to 14.8 kD subunit of NADH:ubiquinone reductase - Neurospora crassa; localisation:mitochondrion; See PMID 10940377; See PMID 8166654; uncharacterized protein 197923 4987668 An15g00690 Aspergillus niger uncharacterized protein XP_001396608.1 197109 D 5061 CDS An15g00700 4987669 complement(join(198502..198635,198710..198786,198871..198962,199037..199195)) III 1 NT_166530.1 Complex: in S. cerevisiae Rpc19p and Rpc40p form a heterodimer that may be a equivalent of alpha homodimers found in E. coli RNA polymerase.; Function: Rpc19p of S. cerevisiae is a shared subunit of RNA polymerases I and III.; Remark: YNL113W is the systematic name for RPC19.; Similarity: Rpc19p of S. cerevisiae belongs to the archaebacteria RPOL/eukaryotic RPB11/RPC19 RNA polymerase family.; Title: strong similarity to 16 kD subunit of DNA-directed RNA polymerase I,III Rpc19 - Saccharomyces cerevisiae; nucleus; See PMID 1869554; uncharacterized protein 199195 4987669 An15g00700 Aspergillus niger uncharacterized protein XP_001396609.3 198502 R 5061 CDS An15g00710 84593083 complement(join(199444..199618,199766..199826,199924..200028,200121..200140,200330..200356,200789..200826)) III 1 NT_166530.1 hypothetical protein 200826 84593083 An15g00710 Aspergillus niger hypothetical protein XP_059602422.1 199444 R 5061 CDS An15g00720 84593084 join(202604..202816,202860..202916) III 1 NT_166530.1 hypothetical protein 202916 84593084 An15g00720 Aspergillus niger hypothetical protein XP_059602423.1 202604 D 5061 CDS An15g00728 4987672 204230..205378 III 1 NT_166530.1 hypothetical protein 205378 4987672 An15g00728 Aspergillus niger hypothetical protein XP_001396612.3 204230 D 5061 CDS An15g00730 4987673 complement(join(206294..207259,207312..207485)) III 1 NT_166530.1 Title: strong similarity to hypothetical protein 99H12.280 - Neurospora crassa; uncharacterized protein 207485 4987673 An15g00730 Aspergillus niger uncharacterized protein XP_059602424.1 206294 R 5061 CDS An15g00740 4987674 208356..210047 III 1 NT_166530.1 Title: similarity to hypothetical protein SPBC1271.03c - Schizosaccharomyces pombe; uncharacterized protein 210047 4987674 An15g00740 Aspergillus niger uncharacterized protein XP_001396614.3 208356 D 5061 CDS An15g00750 84593085 complement(210776..>211249) III 1 NT_166530.1 Complex: elongation factor 1 is composed of four subunits: alpha, beta, delta, and gamma.; Function: elongation factor 1-gamma probably plays a role in anchoring the complex to other cellular components.; Remark: CAM1 and YPL048W are alternativ names for TEF3.; Remark: the ORF encoded protein is N-terminally truncated due to the contig border.; Title: strong similarity to elongation factor 1-gamma 1 Tef3 - Saccharomyces cerevisiae [truncated ORF]; cytoplasm; See PMID 8041634; uncharacterized protein 211249 84593085 An15g00750 Aspergillus niger uncharacterized protein XP_059602425.1 210776 R 5061 CDS An15g00760 4987675 complement(join(<211354..211460,211701..211902,212008..212037)) III 1 NT_166530.1 Function: Elongation factor 1 mediates the transport of aminoacyl-tRNA to 80S ribosomes. It is composed of three subunits, named alpha, beta and gamma.; Remark: the ORF encoded protein also shows strong similarity to a hypothetical protein in A. nidulans that might play a role in sterigmatocystin biosynthesis (PMID 8643646) and similarity to glutathione S-transferase of Issatchenkia orientalis (PMID 10217793).; Remark: the ORF encoded protein is C-terminally truncated due to the contig border.; Title: strong similarity to translation elongation factor eEF-1 gamma chain - Artemia sp. [truncated ORF]; cytoplasm; See PMID 3666137; uncharacterized protein 212037 4987675 An15g00760 Aspergillus niger uncharacterized protein XP_001396615.3 211354 R 5061 CDS An15g00770 4987677 join(212674..213247,213322..213413) III 1 NT_166530.1 Function: MRP-S9 of S. cerevisiae plays a role in assembly and/or function of the 30s subunit of yeast mitochondrial ribosomes.; Phenotype: S. cerevisiae cells disrupted in the chromosomal copy of MRP-S9 were unable to respire and displayed a characteristic phenotype of mutants with defects in mitochondrial protein synthesis as indicated by a loss of cytochrome c oxidase activity.; Remark: YBR146w is the systematic name for MRP-S9.; Title: strong similarity to mitochondrial ribosomal protein of the small subunit S9 - Saccharomyces cerevisiae; localisation:mitochondrion; mitochondrial 37S ribosomal protein uS9m 213413 4987677 An15g00770 Aspergillus niger mitochondrial 37S ribosomal protein uS9m XP_001396617.3 212674 D 5061 CDS An15g00780 84593086 complement(join(218154..218289,218342..218586)) III 1 NT_166530.1 Remark: HMD1 and YPL190C are alternative names for NAB3.; Title: weak similarity to RNA binding protein Nab3 -Saccharomyces cerevisiae; uncharacterized protein 218586 84593086 An15g00780 Aspergillus niger uncharacterized protein XP_059602426.1 218154 R 5061 CDS An15g00790 4987679 join(218977..218981,219181..220103,220309..220575,220641..220711) III 1 NT_166530.1 Title: similarity to hypothetical protein 82C3.050 -Neurospora crassa; uncharacterized protein 220711 4987679 An15g00790 Aspergillus niger uncharacterized protein XP_059602427.1 218977 D 5061 CDS An15g00800 84593087 complement(join(222140..222210,222355..222538,222612..222630,222851..224043)) III 1 NT_166530.1 Title: weak similarity to hypothetical protein encoded by An14g07230 - Aspergillus niger; uncharacterized protein 224043 84593087 An15g00800 Aspergillus niger uncharacterized protein XP_059602428.1 222140 R 5061 CDS An15g00810 4987681 join(224647..224795,224957..226301,226448..226549) III 1 NT_166530.1 Title: similarity to hypothetical zinc-finger protein CAC28841.2 - Neurospora crassa; uncharacterized protein 226549 4987681 An15g00810 Aspergillus niger uncharacterized protein XP_001396621.3 224647 D 5061 CDS An15g00820 4987682 complement(join(226715..226940,227018..227160,227253..227588,227644..227881,227937..229381)) III 1 NT_166530.1 Remark: blastp matches are due to repetitiv amino acids.; Title: weak similarity to Alpha-D-glucosyltransferase from patent WO9606173-A1 -Streptococcus salivarius; uncharacterized protein 229381 4987682 An15g00820 Aspergillus niger uncharacterized protein XP_059602429.1 226715 R 5061 CDS An15g00830 4987683 complement(229775..230776) III 1 NT_166530.1 hypothetical protein 230776 4987683 An15g00830 Aspergillus niger hypothetical protein XP_001396623.1 229775 R 5061 CDS An15g00840 4987684 complement(join(231366..231985,232038..232125,232177..232622,232678..232797,232856..233022,233083..233291)) III 1 NT_166530.1 Catalytic activity: chitinase hydrolyses the 1,4-beta-linkages of N-acetyl-D-glucosamine polymers of chitin.; Remark: chitodextrinase, 1,4-beta-poly-N-acetylglucosaminidase and poly-beta-glucosaminidase are alternative names for chitinase.; Title: strong similarity to chitinase - Chelonus sp.; See PMID 8063715; uncharacterized protein 233291 4987684 An15g00840 Aspergillus niger uncharacterized protein XP_001396624.1 231366 R 5061 CDS An15g00850 4987685 join(233688..234068,234133..235668) III 1 NT_166530.1 Title: similarity to hypothetical secreted hydrolase - Streptomyces avermitilis; uncharacterized protein 235668 4987685 An15g00850 Aspergillus niger uncharacterized protein XP_001396625.1 233688 D 5061 CDS An15g00860 4987686 join(236315..236582,236650..236888,236941..236965,237016..237365,237401..237865) III 1 NT_166530.1 Title: similarity to hypothetical protein CAD79655.1 - Neurospora crassa; uncharacterized protein 237865 4987686 An15g00860 Aspergillus niger uncharacterized protein XP_059602430.1 236315 D 5061 CDS An15g00870 4987687 complement(join(239122..239509,239595..239668,239738..239790,239868..239976)) III 1 NT_166530.1 Function: cnb-1 antisense expression caused increase in hyphal branching, changes in hyphal morphology and concomitant loss of the distinctive tip-high Ca2+ gradient typical for growing wild-type hyphae and finally growth arrest.; Function: cnb-1 of N. crassa has a specific role in the precise regulation of apical growth.; Title: strong similarity to calcineurin subunit B cnb-1 - Neurospora crassa; See PMID 9349701; uncharacterized protein 239976 4987687 An15g00870 Aspergillus niger uncharacterized protein XP_001396627.3 239122 R 5061 CDS An15g00880 4987688 join(240507..240647,240789..241271,241338..241634,241690..242493) III 1 NT_166530.1 Function: in D. melanogaster E(Pc) may have a wider role in chromatin formation or gene regulation than other Polycomb group genes.; Localization: in D. melanogaster E(Pc) is a chromatin protein, binding to polytene chromosomes at about 100 sites.; Phenotype: mutations in E(Pc) in D. melanogaster are strong enhancers of mutations in many Polycomb group genes and are also strong suppressors of position-effect variegation.; Title: similarity to polycomb protein enhancer E(Pc) - Drosophila melanogaster; See PMID 9735366; uncharacterized protein 242493 4987688 An15g00880 Aspergillus niger uncharacterized protein XP_001396628.3 240507 D 5061 CDS An15g00890 4987689 complement(join(242964..243458,243518..243745,243807..244402,244511..244661)) III 1 NT_166530.1 Remark: YDR257C is the systematic name for RMS1.; Title: strong similarity to hypothetical regulator protein Rms1 - Saccharomyces cerevisiae; uncharacterized protein 244661 4987689 An15g00890 Aspergillus niger uncharacterized protein XP_001396629.1 242964 R 5061 CDS An15g00900 4987690 join(245242..245593,245750..246483) III 1 NT_166530.1 Function: O-sialoglycoprotein endopeptidase does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated.; Function: O-sialoglycoprotein endopeptidase of P. haemolytica specifically hydrolyzes O-linked sialoglycoproteins.; Similarity: O-sialoglycoprotein endopeptidase of P. haemolytica belongs to peptidase family M22.; Title: strong similarity to O-sialoglycoprotein endopeptidase - Pasteurella haemolytica; See PMID 9314606; uncharacterized protein 246483 4987690 An15g00900 Aspergillus niger uncharacterized protein XP_001396630.1 245242 D 5061 CDS An15g00910 4987691 complement(join(247273..247320,247370..247955,248059..248801)) III 1 NT_166530.1 Complex: the Snf1 kinase is a heterotrimeric enzyme composed of a catalytic alpha-subunit, a regulatory gamma-subunit and a beta-subunit that mediates heterotrimer formation. S. cerevisiae encodes three beta-subunit genes,SIP1, SIP2 and GAL83.; Function: the yeast SNF1 complex is switched on by glucose starvation, and its targets include transcription factors that repress transcription of genes required for catabolism of alternative carbon sources.; Localization: Green fluorescent protein fusions to Gal83, Sip1, and Sip2 show different patterns of localization to the nucleus, vacuole, and/or cytoplasm.; Phenotype: the sip1Delta sip2Delta gal83Delta strain is unable to derepress invertase, grows poorly on alternative carbon sources and fails to direct the phosphorylation of the Mig1 and Sip4 proteins in vivo.; Remark: SPM2 and YGL208W are alternative names for SIP2.; Title: strong similarity to protein Sip2 -Saccharomyces cerevisiae; See PMID 10990457; See PMID 11331606; uncharacterized protein 248801 4987691 An15g00910 Aspergillus niger uncharacterized protein XP_001396631.1 247273 R 5061 CDS An15g00920 4987692 251325..252800 III 1 NT_166530.1 Function: Ttp1 participates in the cellular event of glycoprotein glycosylation essential for growth and morphogenesis, in parallel with the pathways involving Mpk1 MAP kinase and calcineurin.; Golgi; Phenotype: mnn2 mutants are defective in the addition of the first -1,2-linked mannose as it has no branches on the backbone.; Remark: TTP1 (type II membrane protein) and YBR015C are alternative names for MNN2.; Title: similarity to mannosyltransferases Mnn2 -Saccharomyces cerevisiae; See PMID 9413431; See PMID 9756928; uncharacterized protein 252800 4987692 An15g00920 Aspergillus niger uncharacterized protein XP_001396632.1 251325 D 5061 CDS An15g00930 4987693 complement(join(253146..253175,253279..254378,254427..254709,254766..255533)) III 1 NT_166530.1 Function: abc1p has a dual function: overexpression of abc1p in S. cerevisiae suppresses a cytochrome b mRNA translation defect and the protein is essential for the electron transfer in the bc1 complex.; Function: it is possible that abc1 is involved in the correct folding and/or assembly of cytochrome b and that this folding occurs during the translation process.; Phenotype: the inactivation of abc1 in S. cerevisiae leads to a respiratory deficiency suggesting a block in the bc1 segment of the respiratory chain.; Remark: YGL119w is an alternative name for ABC1.; Similarity: abc1 of S. cerevisiae belongs to the abc1 family.; Similarity: shows also weak similarity to ABC transporters.; Title: strong similarity to chaperone for ubiquinol-cytochrome c reductase Abc1 - Saccharomyces cerevisiae; See PMID 1648478; See PMID 9210471; uncharacterized protein 255533 4987693 An15g00930 Aspergillus niger uncharacterized protein XP_059602431.1 253146 R 5061 CDS An15g00940 4987694 join(255833..255971,256070..256827) III 1 NT_166530.1 Catalytic activity: urease catalyzes the reaction Urea + H(2)O <=> CO(2) + 2 H(3).; Function: the accessory protein ureF is proposed to modulate the activation process of urease by eliminating the binding of nickel irons to noncarbamylated protein.; Title: similarity to urease accessory protein ureF -Actinobacillus pleuropneumoniae; See PMID 9353010; uncharacterized protein 256827 4987694 An15g00940 Aspergillus niger uncharacterized protein XP_059602432.1 255833 D 5061 CDS An15g00950 4987695 complement(join(257429..257602,257674..258747,258805..259461,259517..259660,259787..>259981)) III 1 NT_166530.1 Remark: the ORF encoded protein is N-terminally truncated due to the contig border.; Title: strong similarity to hypothetical membrane protein YDL074c - Saccharomyces cerevisiae [truncated ORF]; uncharacterized protein 259981 4987695 An15g00950 Aspergillus niger uncharacterized protein XP_059602433.1 257429 R 5061 CDS An15g00960 4987696 join(260315..260342,260422..262127) III 1 NT_166530.1 Complex: Tfc5p (chain B') in S. cerevisiae forms part of TFIIIB, composed of B', Brf, and TBP.; Function: TFIIIB in S. cerevisiae binds autonomously to the SNR6 (U6 snRNA) promoter.; Function: Tfc5p in S. cerevisiae is involved in the initiation of the transcription of type III genes by RNA polymerase III.; Function: Tfc5p in S. cerevisiae is required for assembly of the TFIIIB-TFIIIC-DNA complex.; Remark: the systematic name of TFC5 in S. cerevisiae is YNL039w.; Title: strong similarity to transcription initiation factor IIIB chain B Tfc5 - Saccharomyces cerevisiae; nucleus; See PMID 10384303; See PMID 7568218; See PMID 8617241; See PMID 9585500; uncharacterized protein 262127 4987696 An15g00960 Aspergillus niger uncharacterized protein XP_059602434.1 260315 D 5061 CDS An15g00970 4987697 complement(262480..263403) III 1 NT_166530.1 Similarity: shows strong similarity to the protein patent database entry GENSEQPROT:W74726; Title: strong similarity to secreted protein fg949_3 from patent WO9846757-A2 - Homo sapiens; extracellular/secretion proteins; uncharacterized protein 263403 4987697 An15g00970 Aspergillus niger uncharacterized protein XP_001396637.1 262480 R 5061 CDS An15g00980 4987698 join(263851..263866,263927..263957,264021..265428) III 1 NT_166530.1 Complex: MMM1 of N. crassa probably forms part of an oligomeric protein complex.; Function: MMM1 in N. crassa is required for normal mitochondrial morphology independently of the major cytoskeletal system used for mitochondrial transport.; Localization: in N. crassa the insertion of MMM1 into the mitochondrial outer membrane is dependent on a mitochondrial surface receptor.; Localization: the N-terminus of MMM1 in N. crassa faces the mitochiondrial intermembrane space and the C-terminus faces the cytoplasm.; Phenotype: mmm1 mutants of N. crassa are female sterile.; Phenotype: mmm1 mutants of N. crassa exhibit abnormal giant mitochondria and abberrant mitochondria distribution.; Title: strong similarity to maintaining mitochondrial morphology protein MMM1 - Neurospora crassa; localisation:mitochondrion; See PMID 10982393; uncharacterized protein 265428 4987698 An15g00980 Aspergillus niger uncharacterized protein XP_001396638.1 263851 D 5061 CDS An15g00990 4987699 complement(join(265664..265798,265860..266231,266340..266369)) III 1 NT_166530.1 Catalytic activity: masB enzyme E2 (containing Ni2+) of K. oxytoca catalyzes the 1,3-oxygenlytic reaction of the aci-reductone intermediate to yield CO, formate, and methylthiopropionic acid.; Catalytic activity: masB enzyme E2' (containing Fe2+) of K. oxytoca catalyzes the 1,2-oxygenlytic reaction of the aci-reductone intermediate to yield formate and methylthio-alpha-ketobutyric acid, the alpha-ketoacid precursor of methionine.; Function: masB of K. oxytoca encodes a protein with two different 5-methylthio-3-oxo-1-penten-1,2-diol dioxygenase activities E2 or E2' in the presence of Ni2+ or Fe2+ respectively.; Pathway: the masB-encoded enzymes E-2 and E-2' in K. oxytoca catalyze different oxidation reactions of an aci-reductone intermediate in the methionine salvage pathway.; Remark: in the cited literature K. oxytoca is designated a derivative of K. pneumoniae.; Remark: the masB-encoded enzymes E-2 and E-2' of K. oxytoca are interconvertable.; Similarity: also shows similarity to the EST z3a11a1. f1 from A. nidulans (EMBLEST:AI213520).; Title: similarity to methionine salvage pathway enzyme E-2/E-2 masB - Klebsiella oxytoca; See PMID 9880484; uncharacterized protein 266369 4987699 An15g00990 Aspergillus niger uncharacterized protein XP_001396639.1 265664 R 5061 CDS An15g01000 4987700 join(266769..266884,266951..268931) III 1 NT_166530.1 Complex: Mto1p of S. cerevisiae probably forms a heterodimeric complex with Mss1p.; Function: MTO1 of S. cerevisiae is involved in the regulation of the processing of mitochondrial COX1 pre-mRNA for subunit 1 of cytochrome oxidase.; Function: gidA of bacteria is involved in the regulation of DNA replication.; Phenotype: mto1 mutants of S. cerevisiae in a paromomycin-resistant background (due to a point mutation in the mitochondrial 15S rRNA) show reduced respiratory competence.; Remark: the systematic gene name of MTO1 in S. cerevisiae is YGL236c.; Similarity: also shows strong similarity to the glucose inhibited division protein gidA of diverse bacteria.; Title: strong similarity to mitochondrial translation optimization protein Mto1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9774408; uncharacterized protein 268931 4987700 An15g01000 Aspergillus niger uncharacterized protein XP_001396640.1 266769 D 5061 CDS An15g01020 4987702 complement(join(270337..270605,270672..270976,271084..271159,271228..271426)) III 1 NT_166530.1 Catalytic activity: Crd1p of S. cerevisiae catalyzes the transfer of a phosphatidyl moiety from CDP-diacylglycerol to phosphatidylglycerol in the presence of Mg2+.; Complex: Crd1p of S. cerevisiae forms an oligomeric complex whose biogenesis and/or activity is influenced by the assembly of cytochrome oxidase.; Localization: Crd1p of S. cerevisiae is located to the inner mitochondrial membrane.; Pathway: Crd1p of S. cerevisiae catalyzes the final step of the cardiolipin biosynthesis.; Phenotype: crd1- mutants of S. cerevisiae are not viable under elevated-temperature conditions.; Phenotype: in crd1- mutants of S. cerevisiae the efficiency of oxidative phosphorylation is decreased.; Remark: the systematic name of CRD1 (CLS1) of S. cerevisiae is YDL142c.; Similarity: belongs to the CDP-alcohol phosphatidyltransferase family.; Title: strong similarity to cardiolipin synthase Crd1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 10769171; See PMID 9370334; See PMID 9442089; See PMID 9462830; See PMID 9614098; uncharacterized protein 271426 4987702 An15g01020 Aspergillus niger uncharacterized protein XP_059602435.1 270337 R 5061 CDS An15g01030 84593088 complement(join(272475..273382,273759..273899,274098..274120,274235..274366,274696..274772,275005..275023,275136..275170)) III 1 NT_166530.1 hypothetical protein 275170 84593088 An15g01030 Aspergillus niger hypothetical protein XP_059602436.1 272475 R 5061 CDS An15g01040 84593089 join(276894..276980,277014..277180,277409..277412,277460..277573,277615..277736,277771..277813) III 1 NT_166530.1 hypothetical protein 277813 84593089 An15g01040 Aspergillus niger hypothetical protein XP_059602437.1 276894 D 5061 CDS An15g01050 84593090 join(279672..279737,279792..279915,280007..280073,280174..280201,280295..280345) III 1 NT_166530.1 Title: weak similarity to hypothetical protein R03H4.2 - Caenorhabditis elegans; uncharacterized protein 280345 84593090 An15g01050 Aspergillus niger uncharacterized protein XP_059602438.1 279672 D 5061 CDS An15g01060 84593091 join(280721..280772,280884..280902,281020..281066,281212..281420) III 1 NT_166530.1 Similarity: also shows weak homology to the C-terminal part of the small nuclear ribonucleoprotein SIK1 of S. cerevisiae involved in 35S rRNA primary transcript processing.; Similarity: also shows weak homology to the N-terminal part of cGMP-gated ion channel proteins from diverse mammalian species.; Similarity: the homology is restricted to a small centrally located region of At2g28290 from A. thaliana.; Title: weak similarity to hypothetical SNF2 subfamily global transcription activator At2g28290 -Arabidopsis thaliana; uncharacterized protein 281420 84593091 An15g01060 Aspergillus niger uncharacterized protein XP_059602439.1 280721 D 5061 CDS An15g01070 84593092 join(282295..282375,282650..283063) III 1 NT_166530.1 hypothetical protein 283063 84593092 An15g01070 Aspergillus niger hypothetical protein XP_059602440.1 282295 D 5061 CDS An15g01080 84593093 complement(join(284942..285026,285193..285443,285622..285783,286211..286367,286497..286561)) III 1 NT_166530.1 hypothetical protein 286561 84593093 An15g01080 Aspergillus niger hypothetical protein XP_059602441.1 284942 R 5061 CDS An15g01090 84593094 join(286925..286964,287043..287172,287264..287413,287520..287616,287698..287859,288205..288383,288621..288713,288790..288922,289146..289226,289311..289367) III 1 NT_166530.1 hypothetical protein 289367 84593094 An15g01090 Aspergillus niger hypothetical protein XP_059602442.1 286925 D 5061 CDS An15g01100 84593095 join(290296..290388,290547..290651,290709..290888) III 1 NT_166530.1 hypothetical protein 290888 84593095 An15g01100 Aspergillus niger hypothetical protein XP_059602443.1 290296 D 5061 CDS An15g01110 4987711 295007..296434 III 1 NT_166530.1 Remark: the gti1 (gluconate transport inducer 1) mutation in S. pombe leads to a 10-fold decrease in the onset of gluconate uptake in response to starvation.; Title: similarity to gluconate transport-inducing protein gti1p - Schizosaccharomyces pombe; See PMID 9372449; uncharacterized protein 296434 4987711 An15g01110 Aspergillus niger uncharacterized protein XP_001396650.1 295007 D 5061 CDS An15g01120 4987712 complement(join(298612..298740,298796..298882,298921..298996,299043..299269,299348..300328)) III 1 NT_166530.1 hypothetical protein 300328 4987712 An15g01120 Aspergillus niger hypothetical protein XP_059602444.1 298612 R 5061 CDS An15g01130 4987713 join(305590..309276,309332..309715,309773..310309) III 1 NT_166530.1 Function: the ATP-binding cassette transporter bfr1 from Schizosaccharomyces pombe confers hyper-resistance to brefeldin A (BFA), an inhibitor of intracellular protein transport. It could serve as an efflux pump of various antibiotics.; Remark: alternate names for S. pombe bfr1 ABC-transporter: SPBC18B5. 01C or hba2.; Similarity: the ORF encoded protein shows also strong similarity to the weak acid pump protein Pdr12 from S. cerevisiae described in patent WO9951746-A1.; Title: strong similarity to brefeldin A resistance protein bfr1p - Schizosaccharomyces pombe; See PMID 7646493; See PMID 7883711; uncharacterized protein 310309 4987713 An15g01130 Aspergillus niger uncharacterized protein XP_001396652.1 305590 D 5061 CDS An15g01140 4987714 complement(join(310731..310758,310997..311251,311330..311430,311493..311725,311853..311913,311967..312084,312132..312304,312359..312541,312622..313437)) III 1 NT_166530.1 Similarity: the ORF encoded protein shows significant similarity to a group of hypothetical proteins,which are homologs to the Caenorhabditis elegans hypothetical protein F52C12. 1.; Title: similarity to tyrosine-DNA phosphodiesterase TDP1 from patent WO200125407-A2 - Homo sapiens; uncharacterized protein 313437 4987714 An15g01140 Aspergillus niger uncharacterized protein XP_059602445.1 310731 R 5061 CDS An15g01150 4987715 join(314256..314274,314386..315161) III 1 NT_166530.1 hypothetical protein 315161 4987715 An15g01150 Aspergillus niger hypothetical protein XP_059602446.1 314256 D 5061 CDS An15g01155 4987716 complement(join(315216..315512,315564..315737)) III 1 NT_166530.1 Title: strong similarity to hypothetical protein CAC18246.1 - Neurospora crassa; uncharacterized protein 315737 4987716 An15g01155 Aspergillus niger uncharacterized protein XP_001396655.1 315216 R 5061 CDS An15g01160 4987717 join(316084..316287,316344..319739) III 1 NT_166530.1 Function: the Dhr1p from S. cerevisiae is a probable ATP-binding RNA helicase, which is required for 18S rRNA synthesis. It associates with the U3 snoRNP and may play a role in restructuring of the pre-rRNA. Depletion of Dhr1 inhibited processing steps that require base pairing of U3 to the 5' end of the 18S rRNA.; Remark: alternate names for S. cerevisiae Dhr1: Ecm16 or YMR128W.; Title: strong similarity to DEAH-box RNA helicase Dhr1 - Saccharomyces cerevisiae; nucleus; See PMID 10982841; uncharacterized protein 319739 4987717 An15g01160 Aspergillus niger uncharacterized protein XP_001396656.1 316084 D 5061 CDS An15g01170 4987718 complement(319977..320606) III 1 NT_166530.1 Complex: the human SRm160 and the related protein SRm300 form a complex that is required for the splicing of specific pre-mRNAs.; Function: the SRm160/300 complex associates with splicing complexes and promotes splicing through interactions with SR family proteins.; Remark: SRm300= 300-kD nuclear matrix antigen.; Title: similarity to splicing coactivator subunit SRM300 - Homo sapiens; nucleus; See PMID 9531537; See PMID 10668804; uncharacterized protein 320606 4987718 An15g01170 Aspergillus niger uncharacterized protein XP_001396657.1 319977 R 5061 CDS An15g01180 4987719 complement(join(321553..321983,322037..322592,322645..322923,322973..324559)) III 1 NT_166530.1 Function: the Pumilio protein from D. melanogaster is involved in translational regulation of hunchback (hb) mRNA, which is essential for posterior patterning of the Drosophila embryo. This regulation is mediated by sequences in the 3'-untranslated region of hb mRNA (the Nanos response elements or NREs.). Nonos and Pumilio are the two important trans-acting factors.; Similarity: the ORF encoded protein belongs to the Pumilio/Mpt5 family. It also shows strong similarity to the human protein of the Pumilio/Mpt5 family described in patent WO9824815-A1.; Title: strong similarity to RNA binding protein Pumilio Pum - Drosophila melanogaster; cytoplasm; See PMID 10541556; See PMID 10662662; uncharacterized protein 324559 4987719 An15g01180 Aspergillus niger uncharacterized protein XP_059602447.1 321553 R 5061 CDS An15g01190 84593096 complement(join(332277..332359,332577..332616,332792..332844,332973..333159,333642..>333770)) III 1 NT_166530.1 Remark: N-terminally truncated ORF due to the end of contig.; Title: weak similarity to hypothetical protein YNL224 - Saccharomyces cerevisiae [truncated ORF]; uncharacterized protein 333770 84593096 An15g01190 Aspergillus niger uncharacterized protein XP_059602448.1 332277 R 5061 CDS An15g01200 84593097 334466..334945 III 1 NT_166530.1 Title: weak similarity to hypothetical protein PA3340 - Pseudomonas aeruginosa; uncharacterized protein 334945 84593097 An15g01200 Aspergillus niger uncharacterized protein XP_059607010.1 334466 D 5061 CDS An15g01210 84593098 join(337438..337755,337832..338572) III 1 NT_166530.1 Title: weak similarity to phospholipid scramblase 3 - Homo sapiens; uncharacterized protein 338572 84593098 An15g01210 Aspergillus niger uncharacterized protein XP_059607011.1 337438 D 5061 CDS An15g01220 84593099 complement(join(339158..339412,339525..339674,339719..339991)) III 1 NT_166530.1 hypothetical protein 339991 84593099 An15g01220 Aspergillus niger hypothetical protein XP_059607012.1 339158 R 5061 CDS An15g01230 4987724 complement(343569..348269) III 1 NT_166530.1 Function: gigas mutant cells are enlarged and repeat S phase without entering M phase, but differentiate normally to produce adult structures.; Similarity: the predicted A. niger protein shows similarity to the gigas protein gig of D. melanogaster, to human tuberous sclerosis 2 protein (TSC2) and related proteins. the best match is to the conserved hypothetical protein SPAC630. 13c of S. pombe.; Title: similarity to gigas protein gig - Drosophila melanogaster; See PMID 10052455; uncharacterized protein 348269 4987724 An15g01230 Aspergillus niger uncharacterized protein XP_001396663.1 343569 R 5061 CDS An15g01240 4987725 join(349077..349146,349257..349567,349624..349794,349871..351195,351251..351333,351389..351692,351748..351927,351979..352423) III 1 NT_166530.1 Title: strong similarity to protein required for accurate mitotic chromosome segregation Cse1 -Saccharomyces cerevisiae; See PMID 8336709; See PMID 9774694; uncharacterized protein 352423 4987725 An15g01240 Aspergillus niger uncharacterized protein XP_001396664.1 349077 D 5061 CDS An15g01250 4987726 complement(join(352738..353139,353219..353413)) III 1 NT_166530.1 Similarity: PrfB belongs to the prokaryotic and mitochondrial release factors family.; Title: similarity to peptide chain release factor 2 PrfB - Streptomyces coelicolor; See PMID 7545157; uncharacterized protein 353413 4987726 An15g01250 Aspergillus niger uncharacterized protein XP_001396665.1 352738 R 5061 CDS An15g01260 84593100 complement(join(355187..355464,355516..355587,355630..355699,355757..355831)) III 1 NT_166530.1 Title: weak similarity to hypothetical protein C24A8.3 - Caenorhabditis elegans; uncharacterized protein 355831 84593100 An15g01260 Aspergillus niger uncharacterized protein XP_059607013.1 355187 R 5061 CDS An15g01270 4987728 complement(join(356327..356596,356653..356703)) III 1 NT_166530.1 Function: the S. cerevisiae PET100 protein is required for the biogenesis of the cytochrome c oxidase. It is probably involved in its assembly into the active holoenzyme.; Remark: alternate name for S. cerevisiae Pet100: YDR079W.; Title: similarity to assembly factor of cytochrome c oxidase Pet100 - Saccharomyces cerevisiae; See PMID 8702496; uncharacterized protein 356703 4987728 An15g01270 Aspergillus niger uncharacterized protein XP_001396667.1 356327 R 5061 CDS An15g01280 4987729 join(357365..357561,357628..358264) III 1 NT_166530.1 Function: A bacterially expressed form of the S. cerevisiae Eci1 protein catalyzed the isomerization of 3-cis-octenoy-CoA to 2-trans-octenoyl-CoA.; Remark: A S. cerevisiae mutant devoid of Eci1 was unable to grow on media containing unsaturated fatty acids such as oleic acid but was proficient for growth when a saturated fatty acid such as palmitic acid was the sole carbon source.; Remark: alternate name for S. cerevisiae Eci1: YLR284c.; Title: strong similarity to delta3-cis-delta2-trans-enoyl-CoA isomerase Eci1 -Saccharomyces cerevisiae; peroxisome; See PMID 9813046; See PMID 9837886; uncharacterized protein 358264 4987729 An15g01280 Aspergillus niger uncharacterized protein XP_001396668.1 357365 D 5061 CDS An15g01290 4987730 complement(join(358502..358719,358861..359627,359692..359822)) III 1 NT_166530.1 Remark: the human D123 protein is identical to the protein described in patent JP08092288-A and to the human HT-1080 protein.; Title: strong similarity to protein D123 - Homo sapiens; See PMID 8601400; uncharacterized protein 359822 4987730 An15g01290 Aspergillus niger uncharacterized protein XP_059607014.1 358502 R 5061 CDS An15g01300 4987731 join(360386..360497,360554..362616) III 1 NT_166530.1 Title: weak similarity to suppressor of telomeric repression-7 STR7 from patent WO9612811-A2 - Saccharomyces cerevisiae; uncharacterized protein 362616 4987731 An15g01300 Aspergillus niger uncharacterized protein XP_001396670.3 360386 D 5061 CDS An15g01310 4987732 join(362944..364093,364155..364354) III 1 NT_166530.1 Function: the MOZ protein represents a chromatin-associated acetyltransferase.; Remark: the human MOZ protein participates in a T(8; 16)(P11;P13) chromosomal translocation that produces a MOZ-CBP chimaera observed in the M4/M5 subtype of acute myeloid leukemia.; Title: similarity to monocytic leukemia zinc finger protein MOZ - Homo sapiens; See PMID 10839822; See PMID 11243405; uncharacterized protein 364354 4987732 An15g01310 Aspergillus niger uncharacterized protein XP_001396671.1 362944 D 5061 CDS An15g01320 4987733 complement(join(365033..366607,366665..366966,366998..367244,367304..368581,368645..369001,369057..371504)) III 1 NT_166530.1 Title: strong similarity to hypothetical protein pi070 - Schizosaccharomyces pombe; uncharacterized protein 371504 4987733 An15g01320 Aspergillus niger uncharacterized protein XP_059607015.1 365033 R 5061 CDS An15g01330 4987734 join(371808..372021,372086..372711) III 1 NT_166530.1 Similarity: the ORF encoded protein shows also strong similarity to the Chlamydia pneumoniae protein of unknown function described in patent WO9927105-A2.; Title: strong similarity to hypothetical conserved protein aq_1575 - Aquifex aeolicus; uncharacterized protein 372711 4987734 An15g01330 Aspergillus niger uncharacterized protein XP_001396673.1 371808 D 5061 CDS An15g01340 4987735 complement(join(372942..374036,374088..375115,375173..375302)) III 1 NT_166530.1 Function: Mis6 from S. pombe is located in the inner regions of the centromeres and is essential for sister chromatid segregation during the G1/S phase following mitosis.; Similarity: the ORF encoded protein shows strong similarity to the rat protein of unknown function LRPR1.; Title: similarity to inner centromere protein mis6p - Schizosaccharomyces pombe; nucleus; See PMID 9230309; See PMID 10766735; See PMID 10900382; uncharacterized protein 375302 4987735 An15g01340 Aspergillus niger uncharacterized protein XP_059607016.1 372942 R 5061 CDS An15g01350 4987736 complement(join(376083..376400,376456..376941,377015..378016)) III 1 NT_166530.1 Similarity: the ORF encoded protein shows similarity to the functional unknown human secreted protein encoded by gene 55 of the patent WO9931117-A1.; Title: strong similarity to hypothetical cleft lip and palate transmembrane protein 1 CLPTM1 - Homo sapiens; See PMID 9828125; uncharacterized protein 378016 4987736 An15g01350 Aspergillus niger uncharacterized protein XP_001396675.3 376083 R 5061 CDS An15g01360 4987737 join(378520..378794,378853..378938,378996..379160,379215..379285,379351..379908) III 1 NT_166530.1 Catalytic activity: retinol + NADP(+) <=> retinal + NADPH.; Function: the human retinol dehydrogenase (prRDH) catalyzes the reduction of all-trans-retinal to all-trans-retinol within the photoreceptor outer segment.; Title: similarity to all-trans-retinol dehydrogenase from photoreceptor outer segments prRDH - Homo sapiens; See PMID 10753906; uncharacterized protein 379908 4987737 An15g01360 Aspergillus niger uncharacterized protein XP_001396676.1 378520 D 5061 CDS An15g01370 4987738 complement(join(380111..380830,380894..381373,381454..381579)) III 1 NT_166530.1 Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: weak similarity to hypothetical protein CAD70933.1 - Neurospora crassa; uncharacterized protein 381579 4987738 An15g01370 Aspergillus niger uncharacterized protein XP_001396677.1 380111 R 5061 CDS An15g01380 4987739 join(381951..381984,382067..382101,382181..382290,382362..382767,382817..382879) III 1 NT_166530.1 Function: Sec22 from S. cerevisiae is a v-SNARE involved in the visicle transport between the endoplasmic reticulum and Golgi complex.; Remark: SNAREs (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptors) are cytoplasmically oriented membrane proteins that reside on vesicular carriers (v-SNARE) and target organelles (t-SNARE). The pairing of a stage-specific v-SNARE with its cognate t-SNARE may mediate the specificity of membrane traffic.; Remark: alternate names for S. cerevisiae Sec22: Sly2, Tsl26, YLR268W.; Similarity: S. cerevisiae Sec22 belongs to the synaptobrevin family.; Title: strong similarity to Synaptobrevin homolog v-SNARE Sec22 - Saccharomyces cerevisiae; intracellular transport vesicles; See PMID 9202032; See PMID 11001058; uncharacterized protein 382879 4987739 An15g01380 Aspergillus niger uncharacterized protein XP_001396678.1 381951 D 5061 CDS An15g01390 4987740 complement(join(383198..383928,383990..384146,384290..384448)) III 1 NT_166530.1 Function: S. cerevisiae Iki1 is essential for the intracellular killing process of pGKL killer toxin. The S. cerevisiae iki mutants show an insensitive phenotype to the pGKL killer toxin.; Remark: an alternate name for S. cerevisiae Iki1 is YHR187W.; Title: strong similarity to hypothetical killer toxin insensitive protein 1 Iki1 - Saccharomyces cerevisiae; See PMID 9145530; uncharacterized protein 384448 4987740 An15g01390 Aspergillus niger uncharacterized protein XP_001396679.1 383198 R 5061 CDS An15g01400 4987741 join(385837..386161,386220..386614) III 1 NT_166530.1 Similarity: the ORF encoded protein is very repetitive. It has arginine-rich regions and shows similarities to proteins which may be able to bind RNA. The ORF DNA sequence is similar to the E. nidulans EST p0h09a1. r1.; Title: similarity to U1 snRNP 70K protein -Arabidopsis thaliana; See PMID 8776903; uncharacterized protein 386614 4987741 An15g01400 Aspergillus niger uncharacterized protein XP_001396680.1 385837 D 5061 CDS An15g01410 4987742 join(387061..387100,387189..388381) III 1 NT_166530.1 Title: strong similarity to protein fragment SEQ ID NO:57973 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 388381 4987742 An15g01410 Aspergillus niger uncharacterized protein XP_001396681.1 387061 D 5061 CDS An15g01420 4987743 join(388669..388915,388997..389476,389542..389699,389751..389796,389855..390233,390296..391205,391265..391513) III 1 NT_166530.1 Function: S. cerevisiae Cwh41 cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor highly specifically.; Pathway: S. cerevisiae Cwh41 is the first enzyme in the N-linked oligosaccharide processing pathway.; Remark: alternate names for S. cerevisiae Cwh41: Gls1, YGL027C.; Title: strong similarity to glucosidase I Cwh41 -Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 9363442; See PMID 9763440; See PMID 9878780; uncharacterized protein 391513 4987743 An15g01420 Aspergillus niger uncharacterized protein XP_001396682.1 388669 D 5061 CDS An15g01430 4987744 complement(join(391636..392332,392397..392434)) III 1 NT_166530.1 Title: similarity to protein fragment SEQ ID NO:47464 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 392434 4987744 An15g01430 Aspergillus niger uncharacterized protein XP_059607017.1 391636 R 5061 CDS An15g01440 4987745 join(392954..393140,393202..394123,394180..395803) III 1 NT_166530.1 Similarity: the ORF DNA sequence shows also similarity to the E. nidulans EST d5b12a1. f1.; Title: weak similarity to hypothetical protein SPBC27B12.05 - Schizosaccharomyces pombe; uncharacterized protein 395803 4987745 An15g01440 Aspergillus niger uncharacterized protein XP_059607018.1 392954 D 5061 CDS An15g01450 4987746 complement(join(396609..397363,397475..397606,397667..398441)) III 1 NT_166530.1 Complex: In yeast two-hybrid assays the Drosophila protein ARI-1 interacts with a novel ubiquitin-conjugating enzyme UbcD10.; Title: similarity to ariadne-1 protein ari -Drosophila melanogaster; See PMID 10880484; uncharacterized protein 398441 4987746 An15g01450 Aspergillus niger uncharacterized protein XP_059607019.1 396609 R 5061 CDS An15g01460 4987747 join(399768..399815,399905..400094,400165..400631) III 1 NT_166530.1 Remark: S. cerevisiae cwh8/cax4 mutants show an anomalous cell wall, the mutation also affects the actin organization.; Remark: alternate names for S. cerevisiae Cwh8: Cax4 or YGR036c.; Similarity: the S. cerevisiae Cwh8 (Cax4) protein contains 3 short stretches of amino acids that are characteristic for a wide variety of phosphatases,including lipid phosphatases and a protein phosphatase.; Title: strong similarity to Cwh8 - Saccharomyces cerevisiae; See PMID 9725829; See PMID 10024662; uncharacterized protein 400631 4987747 An15g01460 Aspergillus niger uncharacterized protein XP_001396686.1 399768 D 5061 CDS An15g01470 4987748 join(401518..403476,403528..403640,403698..403870,403922..404051,404099..404189,404340..404927) III 1 NT_166530.1 Title: similarity to secreted protein #5 from patent WO200107459-A1 - Homo sapiens; uncharacterized protein 404927 4987748 An15g01470 Aspergillus niger uncharacterized protein XP_059607020.1 401518 D 5061 CDS An15g01480 4987749 join(405293..405354,405503..406430) III 1 NT_166530.1 Localization: SmMAK16, the Schistosoma mansoni homologue of the S. cerevisiae Mak16 protein is localized exclusively in nucleoli (Pubmed 10838225).; Remark: S. cerevisiae mak16 mutants show a decreased amount of free 60S ribosomal subunits. Conditional mutants arrest at G(sub)1, are deficient in maintenance of killer M1 double-stranded RNA.; Remark: alternate name for S. cerevisiae Mak16: YAL025C.; Title: strong similarity to Mak16 - Saccharomyces cerevisiae; nucleus; See PMID 7739558; See PMID 3045810; uncharacterized protein 406430 4987749 An15g01480 Aspergillus niger uncharacterized protein XP_001396688.1 405293 D 5061 CDS An15g01490 4987750 407115..407867 III 1 NT_166530.1 Title: weak similarity to hypothetical conserved protein encoded by 9G6.060 - Araneus diadematus; uncharacterized protein 407867 4987750 An15g01490 Aspergillus niger uncharacterized protein XP_001396689.1 407115 D 5061 CDS An15g01500 4987751 join(409696..410257,410330..411432) III 1 NT_166530.1 Remark: Saccharomyces pastorianus=Saccharomyces carlsbergensis.; Title: strong similarity to fructose symporter Fsy1 - Saccharomyces pastorianus; plasma membrane; See PMID 10986274; uncharacterized protein 411432 4987751 An15g01500 Aspergillus niger uncharacterized protein XP_001396690.1 409696 D 5061 CDS An15g01510 4987752 complement(join(412238..414207,414259..414733,414830..414996,415102..416071)) III 1 NT_166530.1 Function: the S. cerevisiae Drs2 protein is a magnesium dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium . It is involved in the late Golgi function and a possible link between membrane asymmetry and clathrin function at the Golgi complex (Pubmed 10601336). It seems to be less important for aminophospholipid translocation as earlier published (compare Pubmed 8633245 with 9852106;10429211).; Golgi; Localization: Subcellular fractionation and immunofluorescence analysis indicate that Drs2 localizes to late Golgi membranes containing Kex2.; Remark: alternate names for S. cerevisiae Drs2: Fun38, Swa8 or YAL026C.; Title: strong similarity to P-type ATPase Drs2 -Saccharomyces cerevisiae; See PMID 10601336; uncharacterized protein 416071 4987752 An15g01510 Aspergillus niger uncharacterized protein XP_059607021.1 412238 R 5061 CDS An15g01520 4987753 join(416702..416829,417151..417183,417242..422436,422497..423071) III 1 NT_166530.1 Remark: Sec16p S. cerevisiae engages in multiple protein-protein interactions both on the ER membrane and as part of the coat of a completed vesicle. Some Sec16p is localized to the ER by immunofluorescence microscopy. Membrane-associated Sec16p is incorporated into transport vesicles derived from the ER that are formed in an in vitro vesicle budding reaction.; Title: strong similarity to multidomain vesicle coat protein Sec16 - Saccharomyces cerevisiae; See PMID 7593161; uncharacterized protein 423071 4987753 An15g01520 Aspergillus niger uncharacterized protein XP_059607022.1 416702 D 5061 CDS An15g01530 4987754 complement(join(423536..423577,423798..423874,423948..424755,424808..424926,425057..425099)) III 1 NT_166530.1 Complex: Hus1 participates in a protein complex with Rad9 and Rad1.; Localization: Hus1 is a nuclear protein and that this localization depends on Rad17.; Remark: Hus1 fission yeast protein levels are not affected by S-phase arrest, and are not altered by mutations in other checkpoint genes, suggesting that Hus1 is not regulated at the transcriptional or translational levels.; Similarity: the predicted A. niger protein shows strong similarity to mitotic and DNA damage checkpoint protein Hus1 of S. pombe and homologous proteins from diverse eucaryotic species.; Title: strong similarity to mitotic and DNA damage checkpoint protein hus1p - Schizosaccharomyces pombe; See PMID 9180692; See PMID 10648611; uncharacterized protein 425099 4987754 An15g01530 Aspergillus niger uncharacterized protein XP_059607023.1 423536 R 5061 CDS An15g01540 84593101 join(425860..425949,426023..426094,426183..426321,426379..426424,426518..426799,426947..427015,427219..427419,427458..427510,427588..427700) III 1 NT_166530.1 hypothetical protein 427700 84593101 An15g01540 Aspergillus niger hypothetical protein XP_059607024.1 425860 D 5061 CDS An15g01550 10098198 427945..432069 III 1 NT_166530.1 Title: similarity to hypothetical conserved protein B11N2.10 - Neurospora crassa; uncharacterized protein 432069 10098198 An15g01550 Aspergillus niger uncharacterized protein XP_059607025.1 427945 D 5061 CDS An15g01560 4987757 complement(join(433087..433475,433539..433857,433913..434175,434230..435601,435667..435822)) III 1 NT_166530.1 Remark: Gyp7p S. cerevisiae was able to most effectively accelerate the intrinsic GTPase activity of Ypt7p. It was also active, but to a lesser extent, on Ypt31p, Ypt32p and Ypt1p. Ypt6p, Sec4p and the human H-Ras protein did not serve as substrates.; Title: strong similarity to GTPase activating protein Gyp7 - Saccharomyces cerevisiae; See PMID 10091609; See PMID 10508155; uncharacterized protein 435822 4987757 An15g01560 Aspergillus niger uncharacterized protein XP_001396696.1 433087 R 5061 CDS An15g01570 84593102 complement(join(435948..436044,436138..436258,436350..436415,436622..436685)) III 1 NT_166530.1 hypothetical protein 436685 84593102 An15g01570 Aspergillus niger hypothetical protein XP_059607026.1 435948 R 5061 CDS An15g01580 4987759 join(437598..437816,437899..438298,438359..438486) III 1 NT_166530.1 Remark: weak similarity to H. pylori cell envelope protein 05ae20220orf32 patent WO9640893-A1.; Title: weak similarity to cell envelope protein 05ae20220orf32 from patent WO9640893-A1 - Helicobacter pylori; uncharacterized protein 438486 4987759 An15g01580 Aspergillus niger uncharacterized protein XP_059607027.1 437598 D 5061 CDS An15g01590 4987760 join(438945..439225,439295..439764,439830..440175,440230..440459,440517..440530) III 1 NT_166530.1 Remark: Growth of Alcaligenes sp. strain O-1 with 2-aminobenzenesulfonate (ABS; orthanilate) as sole source of carbon and energy requires expression of the soluble,multicomponent 2-aminobenzenesulfonate 2,3-dioxygenase system (deaminating) (ABSDOS).; Similarity: belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family.; Title: similarity to 2-aminobenzenesulfonate dioxygenase large subunit absA - Alcaligenes sp.; putative frameshift; See PMID 10589735; uncharacterized protein 440530 4987760 An15g01590 Aspergillus niger uncharacterized protein XP_059607028.1 438945 D 5061 CDS An15g01600 4987761 join(441508..441606,441702..441755,441798..442106,442359..442490) III 1 NT_166530.1 Title: similarity to hypothetical peroxisomal organisation and biogenesis protein SPAC3G6.05 -Schizosaccharomyces pombe; uncharacterized protein 442490 4987761 An15g01600 Aspergillus niger uncharacterized protein XP_059607029.1 441508 D 5061 CDS An15g01610 84593103 complement(join(442787..443004,443102..443163,443628..443742,443835..444086,444600..444688,444847..444953)) III 1 NT_166530.1 hypothetical protein 444953 84593103 An15g01610 Aspergillus niger hypothetical protein XP_059607030.1 442787 R 5061 CDS An15g01620 4987763 join(445116..447357,447511..448352) III 1 NT_166530.1 Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: weak similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942; uncharacterized protein 448352 4987763 An15g01620 Aspergillus niger uncharacterized protein XP_059607031.1 445116 D 5061 CDS An15g01630 84593104 join(448912..448959,449028..449162,449245..449488,449581..449704,449784..449817,449870..449980) III 1 NT_166530.1 hypothetical protein 449980 84593104 An15g01630 Aspergillus niger hypothetical protein XP_059607032.1 448912 D 5061 CDS An15g01640 4987765 join(450402..450445,450528..450694,450779..450917,451113..451249,451300..451351,451417..451619,451673..451741,451791..451877,451932..452132,452165..453682,453743..454383) III 1 NT_166530.1 Title: weak similarity to kinesin light chain KLC -Plectonema boryanum; uncharacterized protein 454383 4987765 An15g01640 Aspergillus niger uncharacterized protein XP_059607033.1 450402 D 5061 CDS An15g01650 4987766 complement(join(455426..455716,455783..457237,457341..457416,457722..457729)) III 1 NT_166530.1 Function: the TetH from Pasteurella multocida gives resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/h+ antiporter.; Similarity: belongs to the prokaryotic drug resistance translocase family.; Title: similarity to tetracycline resistance protein TetH - Pasteurella multocida; See PMID 8109938; uncharacterized protein 457729 4987766 An15g01650 Aspergillus niger uncharacterized protein XP_059607034.1 455426 R 5061 CDS An15g01670 4987768 complement(join(458411..459663,459899..460184,460245..460463)) III 1 NT_166530.1 Remark: SRP101 from Yarrowia lipolytica is presumably involved in protein targeting to and translocation across the endoplasmic reticulum.; Title: strong similarity to signal sequence receptor alpha subunit SRP101 - Yarrowia lipolytica; See PMID 10992287; uncharacterized protein 460463 4987768 An15g01670 Aspergillus niger uncharacterized protein XP_059607035.1 458411 R 5061 CDS An15g01680 4987769 join(460753..461040,461097..461660,461714..461929) III 1 NT_166530.1 Remark: strong similarity to human signal peptide-containing protein (SIGP) (clone ID 2328134) patent WO9933981-A2.; Title: strong similarity to signal peptide-containing protein SIGP from patent WO9933981-A2 -Homo sapiens; uncharacterized protein 461929 4987769 An15g01680 Aspergillus niger uncharacterized protein XP_001396707.1 460753 D 5061 CDS An15g01690 4987770 join(463314..463439,463538..463801,463965..464024) III 1 NT_166530.1 Remark: a splice site was detected upstream of the START codon.; Remark: strong similarity to EST BE758857 A. niger.; Remark: there are to L14 proteins in yeast and there are part of the large ribosomal (60s) subunit.; Similarity: belongs to the L14e family of ribosomal proteins.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L14.a - Saccharomyces cerevisiae; cytoplasm; See PMID 9559554; See PMID 10542411; See PMID 10690410; 60S ribosomal protein eL14 464024 4987770 An15g01690 Aspergillus niger 60S ribosomal protein eL14 XP_001396708.1 463314 D 5061 CDS An15g01700 4987771 join(464778..465008,465126..465184,465248..465566) III 1 NT_166530.1 Remark: NAC (nascent polypeptide-associated complex) is an alpha/beta heterodimeric complex binding the newly synthesized polypeptide chains as they emerge from the ribosome.; Remark: a splice site was detected upstream of the START codon.; Remark: differential splicing converts alphaNAC from mouse into a tissue-specific DNA-binding activator and suggest that this regulation may be an important event in the proper control of gene expression during myogenic differentiation.; Title: strong similarity to nascent polypeptide-associated complex alpha chain alpha-NAC - Mus musculus; See PMID 8698236; uncharacterized protein 465566 4987771 An15g01700 Aspergillus niger uncharacterized protein XP_001396709.1 464778 D 5061 CDS An15g01710 4987772 join(466064..466072,466152..466547,466628..466714,466786..466815) III 1 NT_166530.1 Catalytic activity: ATP + H2O = ADP + orthophosphate.; Function: ATP7 from Kluyveromyces lactis is one of the chains of the nonenzymatic component (cf(0) subunit) of the mitochondrial ATPase complex.; Pathway: oxidative phosphorylation; photosynthesis; ATP synthase.; Remark: the subunit D is nuclear encoded.; Similarity: to the H+-transporting ATP synthases chain d.; Title: strong similarity to F1Fo-ATP synthase subunit 7 ATP7 - Kluyveromyces lactis; See PMID 9790576; uncharacterized protein 466815 4987772 An15g01710 Aspergillus niger uncharacterized protein XP_001396710.1 466064 D 5061 CDS An15g01720 4987773 467831..468859 III 1 NT_166530.1 Title: similarity to hypothetical protein encoded by An03g03510 - Aspergillus niger; uncharacterized protein 468859 4987773 An15g01720 Aspergillus niger uncharacterized protein XP_001396711.1 467831 D 5061 CDS An15g01730 84593105 join(469688..469711,469781..469942,470039..470200,470266..470331) III 1 NT_166530.1 hypothetical protein 470331 84593105 An15g01730 Aspergillus niger hypothetical protein XP_059607036.1 469688 D 5061 CDS An15g01740 4987775 complement(join(470485..471937,472011..472249,472297..472557)) III 1 NT_166530.1 Catalytic activity: succinate semialdehyde + NAD+ or NADP+ + H2O = succinate + NADH or NADPH.; Pathway: 4-aminobutyrate (GABA) degradation pathway.; Similarity: belongs to the aldehyde dehydrogenase family.; Title: similarity to succinate-semialdehyde dehydrogenase NAD(P)+ gabD - Escherichia coli; See PMID 8297211; See PMID 2254272; uncharacterized protein 472557 4987775 An15g01740 Aspergillus niger uncharacterized protein XP_059607037.1 470485 R 5061 CDS An15g01750 4987776 complement(473144..474571) III 1 NT_166530.1 Remark: the ORF shows C-terminal similarity to the apurinic/apyrimidinic endonuclease III family.; Title: similarity to hypothetical protein B2J23.160 - Neurospora crassa; uncharacterized protein 474571 4987776 An15g01750 Aspergillus niger uncharacterized protein XP_001396714.3 473144 R 5061 CDS An15g01760 4987777 complement(join(475083..475602,475658..476798,476876..476960)) III 1 NT_166530.1 Catalytic activity: 5-phospho-beta-D-ribosylamine + pyrophosphate + L-Glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O.; Pathway: purine metabolism; glutamate metabolism.; Remark: also strong similarity to Sequence 3 from Ashbya possypii Patent EP0927761.; Remark: northern blots demonstrate that ADE4 expression in yeast is transcriptionally regulated.; Similarity: belongs to the amidophosphoribosyltransferases.; Title: strong similarity to amidophosphoribosyltransferase Ade4 - Saccharomyces cerevisiae; See PMID 6376509; uncharacterized protein 476960 4987777 An15g01760 Aspergillus niger uncharacterized protein XP_001396715.1 475083 R 5061 CDS An15g01770 4987778 join(478440..479848,479902..480334) III 1 NT_166530.1 Catalytic activity: S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA 5-methylcytosine.; Remark: the disruption of masc1 has no effect on viability or methylation maintenance but prevents the de novo methylation of DNA repeats, which takes place after fertilization, through the methylation induced premeiotically (MIP) process.; Similarity: belongs to the site-specific DNA methylase dcm.; Title: strong similarity to C5-DNA methyltransferase Masc1 - Ascobolus immersus; See PMID 9346245; uncharacterized protein 480334 4987778 An15g01770 Aspergillus niger uncharacterized protein XP_001396716.1 478440 D 5061 CDS An15g01780 4987779 join(481612..481725,481802..482579,482635..482819,482882..483313) III 1 NT_166530.1 Catalytic activity: 2-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O.; Pathway: lysine biosynthesis.; Remark: the prpBCDE genes constitute an operon in Salmonella typhimurium which encodes catabolic functions required for propionate catabolism.; Title: strong similarity to 2-methylcitrate dehydratase PrpD - Salmonella typhimurium; See PMID 9006051; See PMID 10482501; uncharacterized protein 483313 4987779 An15g01780 Aspergillus niger uncharacterized protein XP_001396717.3 481612 D 5061 CDS An15g01790 4987780 join(484341..484492,484548..484706,484768..484827,484871..485135,485187..485450,485505..485605,485676..485741,485794..486028,486111..486292,486463..486526) III 1 NT_166530.1 Remark: the DAL5 gene product is highly hydrophobic. DAL5 gene, encoding a necessary component of the allantoate transport system, is constitutively expressed in S. cerevisiae.; Similarity: member of the allantoate family of the major facilitator superfamily (MFS).; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 3275614; See PMID 3301804; uncharacterized protein 486526 4987780 An15g01790 Aspergillus niger uncharacterized protein XP_059607038.1 484341 D 5061 CDS An15g01800 4987781 complement(join(486689..486912,486982..487121,487188..487993,488195..488242)) III 1 NT_166530.1 Remark: strong similarity to corynebacterium glutamicum gene sequence 211 from Patent WO0100842.; Similarity: to metal-dependent amidohydrolases/aminoacylases.; Title: strong similarity to protein from patent WO0100842-A - Corynebacterium glutamicum; uncharacterized protein 488242 4987781 An15g01800 Aspergillus niger uncharacterized protein XP_059607039.1 486689 R 5061 CDS An15g01810 4987782 join(488867..488894,488935..490025,490106..490262,490310..490357,490408..490574,490624..490803) III 1 NT_166530.1 Title: strong similarity to hypothetical protein encoded by An01g11620 - Aspergillus niger; uncharacterized protein 490803 4987782 An15g01810 Aspergillus niger uncharacterized protein XP_059607040.1 488867 D 5061 CDS An15g01820 84593106 complement(join(491115..491190,491335..491496,491798..492210)) III 1 NT_166530.1 Title: weak similarity to lung Kruppel-like factor LKLF - Mus musculus; uncharacterized protein 492210 84593106 An15g01820 Aspergillus niger uncharacterized protein XP_059607041.1 491115 R 5061 CDS An15g01830 4987784 join(492408..492875,492939..493204,493257..495303,495364..496041) III 1 NT_166530.1 Remark: the main function of the ATPases is the adaptation to stress conditions.; Similarity: belongs to the cation transport ATPases.; Title: strong similarity to sodium P-type ATPase ena-1 - Neurospora crassa; See PMID 10712689; uncharacterized protein 496041 4987784 An15g01830 Aspergillus niger uncharacterized protein XP_001396722.3 492408 D 5061 CDS An15g01840 4987785 complement(join(496213..496269,496320..496503,496574..497113,497168..497229)) III 1 NT_166530.1 Remark: a splice site was detected upstream of the START codon.; Remark: strong similarity to Secoisolariciresinol dehydrogenase protein clone SMDEHY511 patent WO9955846-A1.; Remark: the patant protein is involved in lignan biosynthetic pathway.; Similarity: belongs to the dehydrogenases with different specificities.; Title: strong similarity to secoisolariciresinol dehydrogenase SMDEHY511 from patent WO9955846-A1 -Forsythia intermedia; See PMID 10629170; uncharacterized protein 497229 4987785 An15g01840 Aspergillus niger uncharacterized protein XP_001396723.1 496213 R 5061 CDS An15g01850 4987786 join(497861..498296,498348..498604,498650..498702,498746..499439) III 1 NT_166530.1 Catalytic activity: ATP + L-Glutamate + NH3 = ADP + Orthophosphate + L-Glutamine.; Pathway: glutamate metabolism; peptideglycan biosynthesis; nitrogen metabolism.; Remark: Glutamine synthetase (GS), an essential enzyme in ammonia assimilation and glutamine biosynthesis,has three distinctive types: GSI, GSII and GSIII. Genes for GSI have been found only in bacteria (eubacteria) and archaea (archaebacteria), while GSII genes only occur in eukaryotes and a few soil-dwelling bacteria.; Similarity: belongs to the glutamate-ammonia ligase.; Title: strong similarity to glutamine synthase glnA - Pyrococcus sp; See PMID 7916055; See PMID 9172372; uncharacterized protein 499439 4987786 An15g01850 Aspergillus niger uncharacterized protein XP_001396724.3 497861 D 5061 CDS An15g01860 4987787 join(500653..501013,501075..501700,501753..502106,502165..502452) III 1 NT_166530.1 Catalytic activity: L-malate + CoA = acetyl-CoA + H2O + glyoxylate.; Pathway: pyruvate metabolism; glyoxylate and dicarboxylate metabolism.; Remark: in fungi, the malate synthase proteins are located in glyoxysomes and the deduced acuE and acu-9 proteins both contain a C-terminal S-K-L sequence, which has been implicated in transport into peroxisomes.; Similarity: belongs to the malate synthase family.; Title: strong similarity to malate synthase acuE -Aspergillus nidulans; uncharacterized protein 502452 4987787 An15g01860 Aspergillus niger uncharacterized protein XP_001396725.1 500653 D 5061 CDS An15g01870 4987788 complement(join(503359..505110,505187..505312)) III 1 NT_166530.1 Title: strong similarity to hypothetical protein encoded by An12g05110 - Aspergillus niger; uncharacterized protein 505312 4987788 An15g01870 Aspergillus niger uncharacterized protein XP_059602449.1 503359 R 5061 CDS An15g01880 4987789 complement(join(505636..505772,505926..506118,506210..506494)) III 1 NT_166530.1 Title: strong similarity to hypothetical IgE-binding protein - Aspergillus fumigatus; uncharacterized protein 506494 4987789 An15g01880 Aspergillus niger uncharacterized protein XP_059602450.1 505636 R 5061 CDS An15g01890 4987790 complement(join(508144..508263,508537..508611,508719..511108,511154..511325,511377..511430)) III 1 NT_166530.1 Catalytic activity: hydrolysis of terminal,non-reducing beta-D-glucose residues with release of beta-D-glucose.; Pathway: cyanoamino acid metabolism; starch and sucrose metabolism; flavonoids, stilbene and lignin biosynthesis.; Remark: beta-glucosidase plays a morphogenetic role in the parasitic cycle of C. immitis.; Similarity: belongs to the beta-glucosidase-related glycosidases.; Title: strong similarity to beta-glucosidase precursor bgl2 - Coccidioides immitis; See PMID 11254576; uncharacterized protein 511430 4987790 An15g01890 Aspergillus niger uncharacterized protein XP_001396728.3 508144 R 5061 CDS An15g01900 4987791 complement(join(512289..512422,512491..513428,513475..513956)) III 1 NT_166530.1 Remark: disruption of the CTR locus completely abolished the choline transport activity, indicating that the CTR product is the sole choline transporter in yeast.; Title: strong similarity to choline permease Hnm1 -Saccharomyces cerevisiae; See PMID 2203793; uncharacterized protein 513956 4987791 An15g01900 Aspergillus niger uncharacterized protein XP_001396729.1 512289 R 5061 CDS An15g01910 4987792 complement(join(514589..514643,514693..515367,515417..518040)) III 1 NT_166530.1 Function: the translational elongation factor 3 (EF-3) superfamily stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome.; Remark: the requirement for EF-3 is unique to fungi,a functional analog has not been found in prokaryotes or other eukaryotes.; Similarity: the C. albicans homolog ELF1 has homology to the ATP-binding cassette (ABC) gene family. Members of this gene family include both membrane transport proteins which confer a drug-resistance phenotype, and proteins whose functions are associated with protein translation.; Title: strong similarity to elongation-like factor ELF - Candida albicans; See PMID 9720054; uncharacterized protein 518040 4987792 An15g01910 Aspergillus niger uncharacterized protein XP_001396730.1 514589 R 5061 CDS An15g01920 4987793 join(519212..519268,519320..520456,520505..520708) III 1 NT_166530.1 Catalytic activity: 2-methylcitrate + CoA = propanoyl-CoA + H2O + oxaloacetate; Pathway: propanoate metabolism.; Remark: propionate is oxidized to pyruvate via the methylcitrate cycle. The key enzyme is methylcitrate synthase. A mcsA deletion strain was unable to grow on propionate. The inhibitory growth effect of propionate on glucose medium was enhanced in this strain, which led to the assumption that trapping of the available CoA as propionyl-CoA and/or the accumulating propionyl-CoA itself interferes with other biosynthetic pathways such as fatty acid and polyketide syntheses.; Similarity: belongs to the citrate (si)-synthases.; Title: strong similarity to methylcitrate synthase mcsA - Aspergillus nidulans; See PMID 10712680; uncharacterized protein 520708 4987793 An15g01920 Aspergillus niger uncharacterized protein XP_001396731.1 519212 D 5061 CDS An15g01930 4987794 complement(join(520824..521555,521629..521769,521847..521929,521988..521996,522076..522112,522160..522345,522399..522466,522535..522748)) III 1 NT_166530.1 Remark: Pth11p functions at the cell cortex as an upstream effector of appressorium differentiation in response to surface cues.; Remark: inhibition of of the genes PTH2, PTH3, PTH11 and PTH12 results in the reduction or elimination of the pathogenic phenotype of the fungus. The genes are useful in the design of screens to identify inhibitors of the fungal pathogenic gene products.; Remark: similarity to integral membrane protein PTH11 - Magnaporthe grisea patent WO9913094-A2.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529; uncharacterized protein 522748 4987794 An15g01930 Aspergillus niger uncharacterized protein XP_059602451.1 520824 R 5061 CDS An15g01940 4987795 complement(join(524500..524697,524781..526047,526123..526394)) III 1 NT_166530.1 Function: the ORF seems to be a putative isoamyl alcohol oxidase.; Similarity: strong similarity to thale cress sequence 70 from Patent WO9813478 found in TREMBL:A71637_1.; Similarity: the ORF shows similarity to several oxidoreductases.; Title: strong similarity to antifungal protein from patent WO9813478-A - Arabidopsis thaliana; uncharacterized protein 526394 4987795 An15g01940 Aspergillus niger uncharacterized protein XP_001396733.1 524500 R 5061 CDS An15g01950 4987796 complement(join(527435..527852,527927..529394,529472..529481)) III 1 NT_166530.1 Remark: strong similarity to A. crisogenum Cephalosporin C patent JP06038763-A.; Similarity: belongs to the acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II.; Title: strong similarity to Cephalosporin C from patent JP06038763-A - Acremonium chrysogenum; See PMID 11405634; uncharacterized protein 529481 4987796 An15g01950 Aspergillus niger uncharacterized protein XP_059602452.1 527435 R 5061 CDS An15g01960 4987797 complement(join(530226..530710,530754..531567)) III 1 NT_166530.1 Remark: Fructosyl amino acid oxidase (FAOD), is active toward model compounds of the glycated proteins in blood, N epsilon-fructosyl N sigma-Z-lysine and N-fructosyl valine.; Title: strong similarity to fructosyl amino acid oxidase faoP - Penicillium janthinellum; See PMID 9022674; uncharacterized protein 531567 4987797 An15g01960 Aspergillus niger uncharacterized protein XP_001396735.1 530226 R 5061 CDS An15g01970 4987798 join(532276..533197,533259..533419) III 1 NT_166530.1 Remark: in the CNS Brn-3. 2 is selectively expressed in postmitotic neurons, implying a role in specifying terminally differentiated neuronal phenotypes.; Title: similarity to unassigned homeobox protein Brn-3.2 - Mus sp.; See PMID 7904822; See PMID 8162704; uncharacterized protein 533419 4987798 An15g01970 Aspergillus niger uncharacterized protein XP_001396736.3 532276 D 5061 CDS An15g01980 4987799 complement(join(533691..534023,534090..534232,534316..535090)) III 1 NT_166530.1 Catalytic activity: 6-carboxyhexanoyl-CoA + L-alanine = 8-amino-7-oxononanoate + CoA + CO2.; Pathway: biotin metabolism.; Remark: belongs to a putative biotin synthesis cluster.; Remark: strong similarity to hlamydia pneumoniae transmembrane protein sequence patent WO9927105-A2.; Similarity: belongs to the 7-keto-8-aminopelargonate synthetase and related enzymes.; Title: strong similarity to 8-amino-7-oxononanoate synthase from patent WO9927105-A2 - Chlamydia pneumoniae; uncharacterized protein 535090 4987799 An15g01980 Aspergillus niger uncharacterized protein XP_001396737.1 533691 R 5061 CDS An15g01990 4987800 join(536217..536404,536465..536596,536643..537980,538050..538630,538724..538899) III 1 NT_166530.1 Catalytic activity: S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate.; Pathway: biotin metabolism.; Remark: similarity to metabolic pathway protein patent WO0100843-A/639 from Corynebacterium glutamicum found in TREMBL:AX064357_1.; Remark: the predicted ORF seems N-terminal approximately 250 amino acids to long.; Remark: this ORF is probable a adenosylmethionine-8-amino-7-oxononanoate aminotransferase-like protein and belongs to a putative biotin synthesis cluster.; Similarity: the ORF shows strong similarity to several putative adenosylmethionine--8-amino-7-oxononanoate transaminases.; Title: strong similarity to biotin synthesis enzyme from patent WO0100843-A - Corynebacterium glutamicum; uncharacterized protein 538899 4987800 An15g01990 Aspergillus niger uncharacterized protein XP_059602453.1 536217 D 5061 CDS An15g02000 4987801 join(539949..540155,540237..541184) III 1 NT_166530.1 Catalytic activity: dethiobiotin + sulfur = biotin.; Pathway: biotin metabolism.; Remark: biotin synthase catalyzes the insertion of a sulfur atom between two carbon atoms of dethiobiotin to form biotin in the last step of the biotin biosynthesis pathway.; Similarity: belongs to the biotin and lipoic acid synthetases family.; Title: strong similarity to biotin synthase Bio2 -Saccharomyces cerevisiae; See PMID 8117110; uncharacterized protein 541184 4987801 An15g02000 Aspergillus niger uncharacterized protein XP_001396739.1 539949 D 5061 CDS An15g02010 84593107 complement(join(541339..541471,541542..541903)) III 1 NT_166530.1 hypothetical protein 541903 84593107 An15g02010 Aspergillus niger hypothetical protein XP_059602454.1 541339 R 5061 CDS An15g02020 84593108 join(542024..542101,542589..542656,542708..542857,542927..542994,543081..543194,543285..543357,543440..543548) III 1 NT_166530.1 hypothetical protein 543548 84593108 An15g02020 Aspergillus niger hypothetical protein XP_059602455.1 542024 D 5061 CDS An15g02030 84593109 complement(join(543948..544409,544467..544494,544623..544742,544981..545068,545162..545281,545339..545408)) III 1 NT_166530.1 hypothetical protein 545408 84593109 An15g02030 Aspergillus niger hypothetical protein XP_059602456.1 543948 R 5061 CDS An15g02040 4987805 join(546399..546484,546540..546571,546627..546790) III 1 NT_166530.1 Remark: the N-terminus of the ORF is identical to EST SEQ ID NO:4121 from patent WO200056762-A2.; Title: strong similarity to EST an_3318 -Aspergillus niger; uncharacterized protein 546790 4987805 An15g02040 Aspergillus niger uncharacterized protein XP_001396743.1 546399 D 5061 CDS An15g02050 84593110 complement(join(547693..548104,548216..548395,548435..548691)) III 1 NT_166530.1 Title: similarity to hypothetical protein encoded by An04g09900 - Aspergillus niger; uncharacterized protein 548691 84593110 An15g02050 Aspergillus niger uncharacterized protein XP_059602457.1 547693 R 5061 CDS An15g02060 84593111 549732..549989 III 1 NT_166530.1 hypothetical protein 549989 84593111 An15g02060 Aspergillus niger hypothetical protein XP_059602458.1 549732 D 5061 CDS An15g02070 4987808 551118..552380 III 1 NT_166530.1 Catalytic activity: salicylate + NADH + O(2) <=> catechol + NAD(+) + H(2)O + CO(2).; Cofactor: FAD.; Function: the salicylate 1-monooxygenase NahG from Pseudomonas putida strain PpG7 is involved in the lower napthalene catabolic pathway which involves conversion of salicylate to lower amphibolic intermediates.; Pathway: nahpthalene catabolism and phenylalanine metabolism.; Title: similarity to salicylate hydroxylase nahG -Pseudomonas putida; See PMID 1993181; See PMID 2363715; uncharacterized protein 552380 4987808 An15g02070 Aspergillus niger uncharacterized protein XP_001396746.1 551118 D 5061 CDS An15g02080 4987809 complement(join(552534..554204,554256..554691,554905..555123,555188..555546)) III 1 NT_166530.1 Remark: the regulator An1000 is involved in the gene expression regulation of FLO11, lovF, lovE or acvA.; Remark: the similarity of the ORF encoded protein to blastp matches is restricted to the Fungal Zn(2)-Cys(6) binuclear cluster.; Title: strong similarity to lovF gene expression regulator An1000 from patent WO200257456-A2 - Unclassified organism; nucleus; uncharacterized protein 555546 4987809 An15g02080 Aspergillus niger uncharacterized protein XP_059602459.1 552534 R 5061 CDS An15g02090 4987810 join(556439..557363,557413..557783) III 1 NT_166530.1 Title: strong similarity to hypothetical protein EAA77948.1 - Gibberella zeae; uncharacterized protein 557783 4987810 An15g02090 Aspergillus niger uncharacterized protein XP_059602460.1 556439 D 5061 CDS An15g02100 84593112 complement(join(558276..558421,558558..558589,558638..558675)) III 1 NT_166530.1 hypothetical protein 558675 84593112 An15g02100 Aspergillus niger hypothetical protein XP_059602461.1 558276 R 5061 CDS An15g02110 4987812 join(560315..560611,560648..560703,560759..561739,561814..562050,562110..562141,562271..562323) III 1 NT_166530.1 Catalytic activity: Penicillin + H2O = a Carboxylate + 6-Aminopenicillanate.; Remark: PVA is used for the enzymatic hydrolysis of penicillin V (phenoxy-methylpenicillin) to 6-aminopenicillanic acid (6-APA). 6-APA is the active beta-lactam nucleus used in the manufacture of semi-synthetic penicillins.; Title: similarity to penicillin V amidohydrolase PVA from patent US5516679-A - Fusarium oxysporum; uncharacterized protein 562323 4987812 An15g02110 Aspergillus niger uncharacterized protein XP_059602462.1 560315 D 5061 CDS An15g02120 4987813 complement(562511..564532) III 1 NT_166530.1 Phenotype: A. nidulans cells lacking the tcsA gene are unable to produce conidia on standard Aspergillus growth media.; Remark: the ORF encoded protein shows similarity to many hypothetical two component histidin kinases and contains a corresponding PFAM domain.; Remark: the tscA protein has not been described.; Title: strong similarity to histidine kinase tcsA -Aspergillus nidulans; See PMID 10905426; uncharacterized protein 564532 4987813 An15g02120 Aspergillus niger uncharacterized protein XP_001396751.1 562511 R 5061 CDS An15g02130 4987814 complement(join(566636..567505,567563..567883,567951..573410,573481..573637,573698..574131,574189..574457,574518..574662,574728..574940)) III 1 NT_166530.1 Function: lovF from A. terreus specifies formation of 2-methylbutyrate.; Remark: lovF is synonymous to lovastatin diketide synthase LDKS.; Title: strong similarity to lovastatin diketide synthase lovF - Aspergillus terreus; See PMID 10334994; See PMID 10381407; uncharacterized protein 574940 4987814 An15g02130 Aspergillus niger uncharacterized protein XP_001396752.1 566636 R 5061 CDS An15g02140 4987815 complement(join(575093..575235,575332..575793,575847..575924,575993..576011,576129..576170)) III 1 NT_166530.1 Similarity: the similarity of the predicted A. niger protein is to the N-termnal region of S. pombe dfr1, while the conserved dihydrofolate reductase domain is at the C-terminus of dfr1.; Title: weak similarity to dihydrofolate reductase dfr1p - Schizosaccharomyces pombe; See PMID 8088538; uncharacterized protein 576170 4987815 An15g02140 Aspergillus niger uncharacterized protein XP_001396753.3 575093 R 5061 CDS An15g02150 4987816 join(577681..578195,578259..578332,578397..578854) III 1 NT_166530.1 Function: the pathogenicity protein PTH11 functions at the cell cortex as an upstream effector of appressorium differentiation in response to surface cues.; Localization: a PTH11-green fluorescent protein fusion was localized to the cell membrane and vacuoles.; Remark: the A. niger protein is 300 amino acids shorter than PTH11.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529; uncharacterized protein 578854 4987816 An15g02150 Aspergillus niger uncharacterized protein XP_001396754.3 577681 D 5061 CDS An15g02160 84593113 complement(join(579139..579568,579724..579875)) III 1 NT_166530.1 Title: similarity to hypothetical protein BAC45498.1 - Bradyrhizobium japonicum; uncharacterized protein 579875 84593113 An15g02160 Aspergillus niger uncharacterized protein XP_059602463.1 579139 R 5061 CDS An15g02170 84593114 complement(join(580980..581414,581544..581603,581772..581876)) III 1 NT_166530.1 hypothetical protein 581876 84593114 An15g02170 Aspergillus niger hypothetical protein XP_059602464.1 580980 R 5061 CDS An15g02180 4987819 join(581948..581983,582049..582407,582498..583380) III 1 NT_166530.1 Catalytic activity: salicylate hydroxylases convert Salicylate + NADH + O2 = Catechol + NAD+ + H2O + CO2.; Function: NahW of P. stutzeri exhibits a broad substrate specificities and metabolize salicylate,methylsalicylates, and chlorosalicylates.; Function: NahW of P. stutzeri is involved in naphthalene and salicylate metabolism.; Remark: the A. niger protein also shows similarity to 6-hydroxynicotinic acid mono-oxygenase from Pseudomonas fluorescens strain TN5 from patent JP09121864-A.; Remark: the similarity is restricted to small region of the proteins.; Title: similarity to salicylate hydroxylase nahW -Pseudomonas stutzeri; See PMID 10197990; uncharacterized protein 583380 4987819 An15g02180 Aspergillus niger uncharacterized protein XP_059602465.1 581948 D 5061 CDS An15g02190 4987820 join(584464..584765,584827..586165) III 1 NT_166530.1 Function: the bmr3 transporter of B. subtilis functions as a multidrug transporter: it mediates resistance to puromycin, tosufloxacin, and norfloxacin.; Induction: expression of bmr3 is dependent on the growth phase of B. subtilis.; Title: strong similarity to multidrug transporter bmr3 - Bacillus subtilis; See PMID 9023234; uncharacterized protein 586165 4987820 An15g02190 Aspergillus niger uncharacterized protein XP_001396758.1 584464 D 5061 CDS An15g02200 4987821 join(586741..586801,586869..587212,587277..588680) III 1 NT_166530.1 Catalytic activity: AOD1 of C. boidinii converts primary alcohol + O2 = aldehyde + H2O2.; Function: the AOD1 protein of C. boidinii is the first key enzyme for methanol metabolism.; Remark: AOD1 of C. boidinii belongs to the oxidoreductases family.; Similarity: the A. niger EST ID NO:4251 in PATENTDNA:AAF11728 overlaps with the ORF at the ORF's extreme C-terminus (patent WO200056762-A2).; Title: strong similarity to alcohol oxidase AOD1 -Candida boidinii; See PMID 1587486; uncharacterized protein 588680 4987821 An15g02200 Aspergillus niger uncharacterized protein XP_001396759.1 586741 D 5061 CDS An15g02210 4987822 complement(join(589021..589640,589703..590173,590241..590474,590534..590615,590670..590711,590771..591016)) III 1 NT_166530.1 Function: the triacylglycerol of C. rugosa mediates the breakdown of lipids.; Remark: C. rugosa is also named C. cylindricacea.; Remark: the triacylglycerol lipase of C. rugosa belongs to the type-B carboxylesterase/lipase family.; Similarity: the ORF shows also strong similarity to the cholesterol esterase of C. rugosa.; Title: strong similarity to extracellular triacylglycerol lipase Lip1 - Candida rugosa; See PMID 8142346; See PMID 8509417; See PMID 11457462; See PMID 1610906; uncharacterized protein 591016 4987822 An15g02210 Aspergillus niger uncharacterized protein XP_059602466.1 589021 R 5061 CDS An15g02220 84593115 join(593256..593397,593483..593757) III 1 NT_166530.1 hypothetical protein 593757 84593115 An15g02220 Aspergillus niger hypothetical protein XP_059602467.1 593256 D 5061 CDS An15g02230 84593116 complement(join(594212..594529,594907..594946,595070..595080)) III 1 NT_166530.1 Remark: unusual exon/intron structure for A. niger and short length (122 amino acids).; hypothetical protein 595080 84593116 An15g02230 Aspergillus niger hypothetical protein XP_059602468.1 594212 R 5061 CDS An15g02240 84593117 join(595312..595419,595501..595602,595650..595780,595850..595988) III 1 NT_166530.1 hypothetical protein 595988 84593117 An15g02240 Aspergillus niger hypothetical protein XP_059602469.1 595312 D 5061 CDS An15g02250 84593118 complement(596860..597111) III 1 NT_166530.1 Remark: the ORF is short in length; hypothetical protein 597111 84593118 An15g02250 Aspergillus niger hypothetical protein XP_059602470.1 596860 R 5061 CDS An15g02260 84593119 complement(join(597273..597591,597663..597744,597820..597952)) III 1 NT_166530.1 hypothetical protein 597952 84593119 An15g02260 Aspergillus niger hypothetical protein XP_059602471.1 597273 R 5061 CDS An15g02270 4987828 598034..598441 III 1 NT_166530.1 hypothetical protein 598441 4987828 An15g02270 Aspergillus niger hypothetical protein XP_001396766.1 598034 D 5061 CDS An15g02280 4987829 complement(join(598994..599178,599236..599454,599494..599625,599701..600013,600064..600105)) III 1 NT_166530.1 Function: the WOX1 protein of M. musculus is a mitochondrial apoptogenic protein.; Induction: the WOX1 protein of M. musculus downregulates the apoptosis inhibitors Bcl-2 and Bcl-x(L) and upregulates pro-apoptotic p53.; Induction: the WOX1 protein of M. musculus is induced by hyaluronidase.; Localization: WOX1 protein of M. musculus is mainly located in the mitochondria.; Remark: WOX1 of M. musculus belongs to the short-chain dehydrogenases/reductases (sdr) family.; Title: similarity to WW domain-containing oxidoreductase WOX1 - Mus musculus; See PMID 11058590; uncharacterized protein 600105 4987829 An15g02280 Aspergillus niger uncharacterized protein XP_059602472.1 598994 R 5061 CDS An15g02290 4987830 join(601477..602745,602807..602930,602980..603280,603330..603530,603600..603813) III 1 NT_166530.1 Function: mepB of A. fumigatus is probably involved in the intracellular degradation of small peptides.; Phenotype: gene disruption of the mepB gene of A. fumigatus did not reveal any detectable phenotype.; Remark: mepB of A. fumigatus is a cytosolic zinc metalloproteinase of the thimet oligopeptidase family (M3).; Similarity: the ORF shows also strong similarity to S. cerevisiae saccharolysin and to thimet oligopeptidases of various species also involved in cytoplasmic peptide degradation.; Similarity: the extreme C-terminus of the ORF overlaps with the 5' genomic sequence preceding the A. niger abf B gene (see adjacent ORF An15g02300) in EMBL:ANABFB and EMBL:ANABFB1.; Title: strong similarity to cytoplasmic metalloproteinase mepB - Aspergillus fumigatus; cytoplasm; See PMID 9245813; uncharacterized protein 603813 4987830 An15g02290 Aspergillus niger uncharacterized protein XP_001396768.1 601477 D 5061 CDS An15g02300 4987831 605172..606671 III 1 NT_166530.1 Catalytic activity: abfB of A. niger is involved in the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.; Function: abfB of A. niger is involved in degradation of the cell wall polysaccharide L-arabinan.; Gene-ID: abfB;abf2;awabfB;exoB; Similarity: abfB of A. niger belongs to family 54 of glycosyl hydrolases.; Similarity: the ORF differs from the abfB protein from patent EP506190-A in a single amino acid (G19A).; Similarity: the ORF is nearly identical to the abfB protein from A. niger in PIR:S39113: they differ in a single amino acid (D465E).; See PMID 8299175; arabinofuranosidase B abfB-Aspergillus niger 606671 abfB 4987831 abfB Aspergillus niger arabinofuranosidase B abfB-Aspergillus niger XP_001396769.1 605172 D 5061 CDS An15g02310 84593120 complement(join(607120..607629,607687..608892)) III 1 NT_166530.1 Similarity: the ORF overlaps with the A. niger sequence from patent EP506190-A; the overlapping patent sequence is the 3' untranslated sequence of the abfB gene,which is encoded on the neighbouring ORF (An15g02300).; hypothetical protein 608892 84593120 An15g02310 Aspergillus niger hypothetical protein XP_059602473.1 607120 R 5061 CDS An15g02320 4987833 complement(join(609454..610288,610343..610518)) III 1 NT_166530.1 Function: the ATP11 protein of S. cerevisiae (together with ATP12) is essential for the expression of the functional F1-ATPase in acting as a chaperone (it binds the ATPase's beta-subunit).; Localization: the ATP11 protein of S. cerevisiae is found in mitochondria (immunochemical evidence).; Phenotype: ATP11 gene mutants of S. cerevisiae had 10% or less of wild-type ATPase activity.; Remark: alternate names for ATP11 of S. cerevisiae are protein N0357 and YNL315c.; Title: strong similarity to chaperone protein Atp11 - Saccharomyces cerevisiae; See PMID 10681564; See PMID 1532796; uncharacterized protein 610518 4987833 An15g02320 Aspergillus niger uncharacterized protein XP_001396771.1 609454 R 5061 CDS An15g02330 84593121 join(610800..610846,611050..611211,611299..611485) III 1 NT_166530.1 Remark: unusual intron/exon structure for A. niger.; hypothetical protein 611485 84593121 An15g02330 Aspergillus niger hypothetical protein XP_059602474.1 610800 D 5061 CDS An15g02340 4987835 join(612647..612686,612767..612805,612867..613022,613079..613114,613168..613424,613479..613497,613557..613589,613644..613910,613969..614095,614149..614203,614261..614427,614498..614555) III 1 NT_166530.1 Pathway: arg1 of S. cerevisiae in active in the urea cycle, where it is involved in the penultimate step of the arginine biosynthetic pathway.; Phenotype: systematic deletion of the arg1 gene of S. cerevisiae produced a viable phenotype.; Regulation: transcription of arg1 protein of S. cerevisiae is not affected by the presence of arginine in the growth medium whereas enzyme activity is.; Remark: Alternate names for arg1 of S. cerevisiae are arg10, citrulline-aspartate ligase, protein O1228, and YOL058w.; Remark: arg1 of S. cerevisiae is a member of the argininosuccinate synthase family.; Title: strong similarity to argininosuccinate synthase Arg1 - Saccharomyces cerevisiae; cytoplasm; See PMID 2897249; uncharacterized protein 614555 4987835 An15g02340 Aspergillus niger uncharacterized protein XP_001396773.1 612647 D 5061 CDS An15g02350 4987836 615625..616767 III 1 NT_166530.1 Remark: the ORF has some gaps (one over 30 amino acids) if aligned with the N. crassa protein.; Similarity: the ORF is serine rich and therefore shows unspecific homologies to other serine rich proteins (e. g. D. discoideum spore coat protein sp96).; Title: strong similarity to hypothetical precursor of spore coat protein sp96 - Neurospora crassa; uncharacterized protein 616767 4987836 An15g02350 Aspergillus niger uncharacterized protein XP_001396774.1 615625 D 5061 CDS An15g02360 4987837 complement(617532..618956) III 1 NT_166530.1 Localization: acetylornithine aminotransferases localize to the mitochondrial matrix.; Pathway: acetylornithine aminotransferases catalyze the fourth step in arginine biosynthesis.; Phenotype: disruption of the arg8 gene in K. lactis resulted in strains auxotrophic for arginine.; Remark: acetylornithine aminotransferases belong to class-III of pyridoxal-phosphate-dependent aminotransferases.; Similarity: the A. niger EST an_2621 in EMBLEST:BE759720 overlaps with the ORF.; Title: strong similarity to acetylornithine aminotransferase arg8 - Kluyveromyces lactis; localisation:mitochondrion; See PMID 9544247; uncharacterized protein 618956 4987837 An15g02360 Aspergillus niger uncharacterized protein XP_001396775.1 617532 R 5061 CDS An15g02370 4987838 join(620701..620995,621063..622231) III 1 NT_166530.1 Induction: the expression level of ccg-8 of N. crassa is influenced by circadian rhythm (it preferentially accumulates from light-night to early-morning).; Remark: the ORF shows also similarity to the transcription regulator OPI1 of S. cerevisiae and due to its relatively high serine content unspecific similarity to proteophosphoglycans.; Similarity: the ccg-8 gene of N. crassa is 199 amino acids shorter at the N-terminus than the ORF.; Title: similarity to clock-controlled gene-8 ccg-8 -Neurospora crassa; See PMID 8917550; uncharacterized protein 622231 4987838 An15g02370 Aspergillus niger uncharacterized protein XP_001396776.1 620701 D 5061 CDS An15g02380 4987839 join(623037..624154,624346..>624624) III 1 NT_166530.1 Remark: the ORF is C-terminally truncated due to the contig border.; Title: strong similarity to hypothetical transmembrane protein SPAC977.11 - Schizosaccharomyces pombe [truncated ORF]; uncharacterized protein 624624 4987839 An15g02380 Aspergillus niger uncharacterized protein XP_001396777.3 623037 D 5061 CDS An15g02390 4987840 complement(<624725..625870) III 1 NT_166530.1 Catalytic activity: estradiol 17beta-dehydrogenase type 1 catalyzes the reaction Estradiol-17-beta + NAD(P)(+) <=> estrone + NAD(P)H.; Remark: the A. niger protein also shows strong similarity to many different hypothetical dehydrogenases and it contains a short chain dehydrogenase PFAM domain.; Title: similarity to estradiol 17-beta-dehydrogenase type 1 - Homo sapiens; See PMID 2779584; See PMID 3456799; uncharacterized protein 625870 4987840 An15g02390 Aspergillus niger uncharacterized protein XP_059606729.1 624725 R 5061 CDS An15g02400 4987841 complement(join(626217..626838,626983..628037)) III 1 NT_166530.1 Remark: the A. niger ORF also shows strong similarity to EST an_0173 of A. niger.; Title: similarity to hypothetical protein CG11840 -Drosophila melanogaster; uncharacterized protein 628037 4987841 An15g02400 Aspergillus niger uncharacterized protein XP_059606730.1 626217 R 5061 CDS An15g02410 4987842 join(629596..629638,629696..629910,629984..630137,630189..630521,630572..630794,631033..631141,631280..631288) III 1 NT_166530.1 Function: hNmrr is a nitrogen metabolic repression regulator protein.; Title: similarity to nitrogen metabolic repression regulator hNmrr from patent CN1269419-A - Homo sapiens; uncharacterized protein 631288 4987842 An15g02410 Aspergillus niger uncharacterized protein XP_001396780.3 629596 D 5061 CDS An15g02420 4987843 join(631613..631738,631806..631860,631937..633006,633061..633137,633192..633250,633313..633353,633411..633560) III 1 NT_166530.1 Function: eIF-2B is a guanin nucleotide releasing protein for eIF-2. eIF-2 forms a complex with GTP and mediates the binding of the methionyl initiator tRNA to the small rubosomal subunit, which then binds to the 5' cap of the mRNA and begins scanning along the mRNA.; Function: eIF-2B is required to cause GDP release so that a nex GTP molecule can bind and eIF2 can be reused.; Title: similarity to eukaryotic translation initiation factor eIF2B subunit 3 - Homo sapiens; cytoplasm; See PMID 10900014; uncharacterized protein 633560 4987843 An15g02420 Aspergillus niger uncharacterized protein XP_001396781.1 631613 D 5061 CDS An15g02440 4987845 complement(<634751..637007) III 1 NT_166530.1 Function: Gcn20p of S. cerevisiae functions together with Gcn1p in facilitating the activation of Gcn2p by uncharged tRNA on translating ribosomes.; Function: Gcn20p of S. cerevisiae is a component of a protein complex that couples the kinase activity of GCN2 to the availability of amino acids.; Remark: the A. niger ORF contains a putative sequencing error at position 28062.; Similarity: Gcn20p of S. cerevisiae is a member of ATP-binding cassette (ABC) family, eF-3 subfamily.; Title: strong similarity to positive effector of Gcn2p Gcn20 - Saccharomyces cerevisiae [putative frameshift]; cytoplasm; putative frameshift; See PMID 7621831; See PMID 9234705; uncharacterized protein 637007 4987845 An15g02440 Aspergillus niger uncharacterized protein XP_059606731.1 634751 R 5061 CDS An15g02450 4987846 complement(join(637389..637781,637856..638144,638197..638620,638673..639084)) III 1 NT_166530.1 Title: weak similarity to regulator protein Ppr1 -Saccharomyces cerevisiae; uncharacterized protein 639084 4987846 An15g02450 Aspergillus niger uncharacterized protein XP_001396783.3 637389 R 5061 CDS An15g02460 4987847 640554..642143 III 1 NT_166530.1 Phenotype: aro8 mutants cannot grow on minimal medium supplemented with tryptophane, kinurenine,phenylalanine and tyrosine.; Remark: YGL202W is the systematic name for ARO8.; Similarity: ARO8 belongs to the aminotransferase subgroup I.; Title: similarity to aromatic aminotransferase I Aro8 - Saccharomyces cerevisiae; See PMID 9491083; See PMID 9491082; uncharacterized protein 642143 4987847 An15g02460 Aspergillus niger uncharacterized protein XP_001396784.1 640554 D 5061 CDS An15g02470 4987848 complement(642805..644325) III 1 NT_166530.1 Title: weak similarity to hypothetical variant surface glycoprotein MVAT5 homolog - Trypanosoma brucei; uncharacterized protein 644325 4987848 An15g02470 Aspergillus niger uncharacterized protein XP_001396785.3 642805 R 5061 CDS An15g02480 84593122 complement(join(644666..645040,645308..645310)) III 1 NT_166530.1 hypothetical protein 645310 84593122 An15g02480 Aspergillus niger hypothetical protein XP_059606732.1 644666 R 5061 CDS An15g02490 4987850 complement(join(645510..646353,646421..646590,646656..646696,646769..646799)) III 1 NT_166530.1 Catalytic activity: leuB of Sulfolobus sp. catalyzes the reaction 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH (the product decarboxylates to 4-methyl-2-oxopentanoate).; Pathway: leuB of Sulfolobus sp. catalyzes the third step in leucine biosynthesis.; Remark: the A. niger protein also shows strong similarity to the unpublished homo-isocitrate dehydrogenase LYS12 of S. cerevisiae that is involved in lysine biosynthesis.; Similarity: leuB of Sulfolobus sp. belongs to the isocitrate and isopropylmalate dehydrogenases family.; Title: similarity to 3-isopropylmalate dehydrogenase leuB - Sulfolobus sp.; See PMID 9023199; uncharacterized protein 646799 4987850 An15g02490 Aspergillus niger uncharacterized protein XP_001396787.1 645510 R 5061 CDS An15g02500 84593123 join(646822..646958,647142..647244,647355..647508,647603..647679) III 1 NT_166530.1 hypothetical protein 647679 84593123 An15g02500 Aspergillus niger hypothetical protein XP_059606733.1 646822 D 5061 CDS An15g02510 84593124 complement(648118..648588) III 1 NT_166530.1 Remark: blastp matches are unspecific.; Title: weak similarity to prokaryotic essential gene #5987 from patent WO200277183-A2 - Bacteroides fragilis; uncharacterized protein 648588 84593124 An15g02510 Aspergillus niger uncharacterized protein XP_059606734.1 648118 R 5061 CDS An15g02520 4987853 complement(join(649260..649595,649908..650285)) III 1 NT_166530.1 hypothetical protein 650285 4987853 An15g02520 Aspergillus niger hypothetical protein XP_001396790.3 649260 R 5061 CDS An15g02530 84593125 join(650329..650372,650702..650867,650996..651190) III 1 NT_166530.1 hypothetical protein 651190 84593125 An15g02530 Aspergillus niger hypothetical protein XP_059606735.1 650329 D 5061 CDS An15g02540 84593126 complement(join(651653..651835,651898..652126,652195..652547)) III 1 NT_166530.1 Title: strong similarity to hypothetical protein encoded by An18g01500 - Aspergillus niger; uncharacterized protein 652547 84593126 An15g02540 Aspergillus niger uncharacterized protein XP_059606736.1 651653 R 5061 CDS An15g02550 4987856 join(653234..654156,654213..654438,654552..654655,654908..654928,654967..655003,655152..655184) III 1 NT_166530.1 Title: strong similarity to hypothetical protein encoded by An19g00370 - Aspergillus niger; uncharacterized protein 655184 4987856 An15g02550 Aspergillus niger uncharacterized protein XP_001396793.3 653234 D 5061 CDS An15g02560 84593127 join(656117..656386,656418..656450) III 1 NT_166530.1 Remark: blastp matches are only due to repetitive amino acids.; hypothetical protein 656450 84593127 An15g02560 Aspergillus niger hypothetical protein XP_059606737.1 656117 D 5061 CDS An15g02570 84593128 join(657090..657182,657262..657323,657416..657571,657626..657689) III 1 NT_166530.1 Title: weak similarity to precursor of agglutinin isolectin 1 - Triticum aestivum; uncharacterized protein 657689 84593128 An15g02570 Aspergillus niger uncharacterized protein XP_059606738.1 657090 D 5061 CDS An15g02580 4987859 join(658022..658144,658372..658964,659118..659230,659368..659374,659474..659549,659665..659705,659815..659892,660078..660096) III 1 NT_166530.1 Title: strong similarity to hypothetical protein encoded by An16g02740 - Aspergillus niger; uncharacterized protein 660096 4987859 An15g02580 Aspergillus niger uncharacterized protein XP_059606739.1 658022 D 5061 CDS An15g02590 4987860 complement(660247..662805) III 1 NT_166530.1 Catalytic activity: human DMGDH catalyzes the reaction N,N-dimethylglycine + acceptor + H2O = sarcosine + formaldehyde + reduced acceptor.; Function: human dimethylglycine dehydrogenase (DMGDH) is a mitochondrial matrix enzyme involved in the metabolism of choline, converting dimethylglycine to sarcosine. Sarcosine is then transformed to glycine by sarcosine dehydrogenase.; Title: strong similarity to dimethylglycine dehydrogenase precursor DMGDH - Homo sapiens; localisation:mitochondrion; See PMID 11231903; uncharacterized protein 662805 4987860 An15g02590 Aspergillus niger uncharacterized protein XP_001396797.1 660247 R 5061 CDS An15g02600 4987861 complement(663523..664221) III 1 NT_166530.1 hypothetical protein 664221 4987861 An15g02600 Aspergillus niger hypothetical protein XP_001396798.3 663523 R 5061 CDS An15g02610 4987862 665083..665937 III 1 NT_166530.1 Function: aphA-6 of A. baumannii phosphorylates, and thereby inactivates, the antibiotic kanamycin and structurally related aminoglycosides.; Title: similarity to kanamycin kinase type IV aphA-6 - Acinetobacter baumannii; See PMID 2846986; uncharacterized protein 665937 4987862 An15g02610 Aspergillus niger uncharacterized protein XP_001396799.1 665083 D 5061 CDS An15g02620 4987863 complement(join(666116..666904,666962..667279,667336..667419)) III 1 NT_166530.1 Title: weak similarity to fungal ZBC protein sequence #116 from patent WO200224865-A2 - Unclassified organism; uncharacterized protein 667419 4987863 An15g02620 Aspergillus niger uncharacterized protein XP_001396800.1 666116 R 5061 CDS An15g02630 4987864 667843..668955 III 1 NT_166530.1 Function: lovC from A. terreus interacts with LNKS and is necessary for the correct processing of the growing polyketide chain and production of dihydromonacolin L.; Function: lovC of A. terreus is involved in lovastatin production.; Similarity: the ORF shows similarity to several unspecified oxidoreductases.; Title: similarity to enoyl reductase lovC from patent WO200037629-A2 - Aspergillus terreus; See PMID 10334994; uncharacterized protein 668955 4987864 An15g02630 Aspergillus niger uncharacterized protein XP_059606740.1 667843 D 5061 CDS An15g02640 4987865 complement(join(669093..669138,669247..670406)) III 1 NT_166530.1 Title: similarity to human cancer associated protein sequence SEQ ID NO:1313 from patent WO200055350-A1 - Homo sapiens; uncharacterized protein 670406 4987865 An15g02640 Aspergillus niger uncharacterized protein XP_001396802.3 669093 R 5061 CDS An15g02650 4987866 complement(join(670785..671144,671213..671299)) III 1 NT_166530.1 Title: similarity to hypothetical protein CC3092 -Caulobacter crescentus; uncharacterized protein 671299 4987866 An15g02650 Aspergillus niger uncharacterized protein XP_001396803.1 670785 R 5061 CDS An15g02660 84593129 complement(672106..672597) III 1 NT_166530.1 Title: strong similarity to essential protein SEQ ID NO:22 from patent WO2003076464-A2 - Aspergillus fumigatus; uncharacterized protein 672597 84593129 An15g02660 Aspergillus niger uncharacterized protein XP_059606741.1 672106 R 5061 CDS An15g02670 84593130 complement(<672699..674733) III 1 NT_166530.1 Remark: the ORF is truncated and contains no stop codon, due to the end of the contig.; Title: strong similarity to essential protein #22 from patent WO2003076464-A2 - Aspergillus fumigatus [truncated ORF]; uncharacterized protein 674733 84593130 An15g02670 Aspergillus niger uncharacterized protein XP_059602475.1 672699 R 5061 CDS An15g02680 4987868 complement(join(675311..675351,675381..676833,676893..677153)) III 1 NT_166530.1 Function: tetA from E. coli encodes a tetracycline cation/proton antiporter.; Function: tetA from E. coli is necessary for tetracycline resistance.; Title: strong similarity to tetracyclin resistance protein tetA - Escherichia coli; plasma membrane; See PMID 11069672; See PMID 6310527; uncharacterized protein 677153 4987868 An15g02680 Aspergillus niger uncharacterized protein XP_059602476.1 675311 R 5061 CDS An15g02690 4987870 complement(join(677954..678411,678472..679054,679123..679344)) III 1 NT_166530.1 Catalytic activity: protoporphyrin + Fe(2+) <=> protoheme + 2 H(+).; Function: catalyzes the insertion of iron into protoporphyrin to produce heme.; Remark: Danio rerio = zebrafish.; Title: strong similarity to ferrochelatase fch -Danio rerio; See PMID 10985389; uncharacterized protein 679344 4987870 An15g02690 Aspergillus niger uncharacterized protein XP_001396807.1 677954 R 5061 CDS An15g02700 4987871 join(679864..679929,679987..680598,680673..681504,681569..681672,681742..681969,682043..682147) III 1 NT_166530.1 Function: Ku70 of M. musculus has a role in chromosome translocation.; Function: Ku70 of M. musculus is a ssDNA/ATP-dependent helicase.; Function: the DNA helicase II complex binds preferentially to fork-like ends of dsDNA in a cell cycle-dependent manner.; Similarity: belongs to the ATP-dependent DNA helicase II 70kDa subunit family.; Title: strong similarity to ATP-dependent DNA helicase II subunit Ku70 - Mus musculus; nucleus; See PMID 10689133; See PMID 1701785; uncharacterized protein 682147 4987871 An15g02700 Aspergillus niger uncharacterized protein XP_059602477.1 679864 D 5061 CDS An15g02710 4987872 complement(join(682859..682907,682981..683616,683683..683933)) III 1 NT_166530.1 Title: strong similarity to hypothetical protein encoded by An02g01160 - Aspergillus niger; uncharacterized protein 683933 4987872 An15g02710 Aspergillus niger uncharacterized protein XP_001396809.1 682859 R 5061 CDS An15g02720 84593131 complement(join(684736..684930,685051..685158,685253..685366)) III 1 NT_166530.1 Title: weak similarity to hypothetical hsp70-related protein ORP150RP - Leishmania major; uncharacterized protein 685366 84593131 An15g02720 Aspergillus niger uncharacterized protein XP_059602478.1 684736 R 5061 CDS An15g02730 84593132 complement(join(687703..687804,687863..688006,688112..688365,688452..688522,688570..688668,688795..688927,689202..689312,689440..689555,689626..689636)) III 1 NT_166530.1 Title: weak similarity to cancer associated protein sequence SEQ ID NO:1409 from patent WO200055350-A1 - Homo sapiens; uncharacterized protein 689636 84593132 An15g02730 Aspergillus niger uncharacterized protein XP_059602479.1 687703 R 5061 CDS An15g02740 4987875 join(689891..690301,690342..694761,694837..694913) III 1 NT_166530.1 Function: apsA of A. nidulans is required for nuclear positioning and completion of asexual development.; Phenotype: apsA mutants of A. nidulans are partially blocked in conidiation (asexual sporulation) due to failure of the organized migration of nuclei into the conidiophore metulae.; Phenotype: apsA mutants of A. nidulans have a slightly reduced hyphal growth rate and en irregular distribution of nuclei in vegetative hyphae.; Remark: Emericella nidulans = Aspergillus nidulans.; Title: strong similarity to anucleate primary sterigmata gene apsA - Aspergillus nidulans; See PMID 8025681; See PMID 7860626; uncharacterized protein 694913 4987875 An15g02740 Aspergillus niger uncharacterized protein XP_059602480.1 689891 D 5061 CDS An15g02750 4987876 complement(join(695623..695709,695821..695858,695970..696421,696484..697541)) III 1 NT_166530.1 Title: similarity to hypothetical protein B13N4.250 - Neurospora crassa; uncharacterized protein 697541 4987876 An15g02750 Aspergillus niger uncharacterized protein XP_001396813.3 695623 R 5061 CDS An15g02760 4987877 join(698630..698740,698927..699241,699350..699466,699534..700517) III 1 NT_166530.1 Complex: Rvs167 from S. cerevisiae may be part of a cytoskeletal complex with Vrp1, Rvs161 and Sac6.; Function: Rvs167 from S. cerevisiae affects actin distribution and bipolar budding.; Phenotype: rvs167 mutants from S. cerevisiae has reduced viability upon starvation.; Phenotype: rvs167 mutants from S. cerevisiae show defectes in sporulation.; Remark: the synonym for Rvs167 from S. cerevisiae is YDR388w.; Title: strong similarity to protein involved in actin distribution and bipolar budding Rsv167 -Saccharomyces cerevisiae; cytoskeleton; See PMID 9395067; See PMID 9434108; See PMID 10992286; uncharacterized protein 700517 4987877 An15g02760 Aspergillus niger uncharacterized protein XP_001396814.1 698630 D 5061 CDS An15g02770 4987878 complement(join(700748..700848,700984..703564)) III 1 NT_166530.1 Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942; uncharacterized protein 703564 4987878 An15g02770 Aspergillus niger uncharacterized protein XP_001396815.3 700748 R 5061 CDS An15g02780 84593133 complement(join(704480..704594,704803..704930,705412..705600)) III 1 NT_166530.1 Remark: about the EST of patent WO200056762-A2 are no further informations available.; Title: strong similarity to EST SEQ ID NO:4136 from patent WO200056762-A2 - Aspergillus niger; uncharacterized protein 705600 84593133 An15g02780 Aspergillus niger uncharacterized protein XP_059602481.1 704480 R 5061 CDS An15g02790 84593134 join(706075..706172,706348..706453,706691..706765) III 1 NT_166530.1 hypothetical protein 706765 84593134 An15g02790 Aspergillus niger hypothetical protein XP_059602482.1 706075 D 5061 CDS An15g02800 84593135 complement(join(707587..708033,708119..708148)) III 1 NT_166530.1 Title: weak similarity to protamine I-1 - Chrysemys picta; uncharacterized protein 708148 84593135 An15g02800 Aspergillus niger uncharacterized protein XP_059602483.1 707587 R 5061 CDS An15g02810 4987882 complement(710865..712190) III 1 NT_166530.1 Catalytic activity: D-myo-inositol 1,4,5-trisphosphate + H(2)O <=> D-myo-inositol 1,4-bisphosphate + phosphate.; Remark: the synonyms for Inp52 from S. cerevisiae are Sjl2, Pie3 and YNL106c.; Similarity: Inp52 from S. cerevisiae belongs to the Inositol-1,4,5-trisphosphate 5-phosphatase type II family.; Title: similarity to phosphatidylinositol phosphate phosphatase Inp52 - Saccharomyces cerevisiae; See PMID 9560389; See PMID 10029994; uncharacterized protein 712190 4987882 An15g02810 Aspergillus niger uncharacterized protein XP_059602484.1 710865 R 5061 CDS An15g02820 4987883 complement(join(712554..714462,714515..714558)) III 1 NT_166530.1 Catalytic activity: ATP + pyruvate + HCO(3)(-) = ADP + phosphate + oxaloacetate.; Cofactor: Biotin, Manganese and acetyl-CoA.; Function: pyruvate carboxylase pcb catalyzes tissue specific the initial reactions of glucose (liver,kidney) and lipid (adipose tissue,liver,brain) synthesis from pyruvate.; Title: strong similarity to pyruvate carboxylase pcb - Homo sapiens; See PMID 7918683; See PMID 3555348; See PMID 6548474; uncharacterized protein 714558 4987883 An15g02820 Aspergillus niger uncharacterized protein XP_001396820.1 712554 R 5061 CDS An15g02830 4987884 join(714832..715461,715524..716106,716168..716646) III 1 NT_166530.1 Catalytic activity: ATP + Propanoyl-CoA + HCO3- = ADP + Orthophosphate + (S)-Methylmalonyl-CoA; Cofactor: Biotin; Function: PCCB of H. sapiens is a biotin-dependent enzyme involved in the degradation of branched-chain amino acids, fatty acids with odd-numbered chain lengths, and other metabolites.; Remark: PCCB of H. sapiens is a biotinyl-protein,carboxylates butanoyl-CoA and catalyses transcarboxylation.; Title: strong similarity to propionyl-CoA carboxylase beta chain precursor PCCB - Homo sapiens; See PMID 2154743; See PMID 3460076; uncharacterized protein 716646 4987884 An15g02830 Aspergillus niger uncharacterized protein XP_001396821.1 714832 D 5061 CDS An15g02840 4987885 join(717074..717161,717228..717703,717874..717930) III 1 NT_166530.1 Title: strong similarity to hypothetical protein CAE76274.1 - Neurospora crassa; uncharacterized protein 717930 4987885 An15g02840 Aspergillus niger uncharacterized protein XP_001396822.3 717074 D 5061 CDS An15g02850 4987886 complement(join(718219..718722,718840..718899)) III 1 NT_166530.1 hypothetical protein 718899 4987886 An15g02850 Aspergillus niger hypothetical protein XP_001396823.1 718219 R 5061 CDS An15g02860 4987887 join(719473..719527,719583..719841,719898..720061,720119..720318,720374..720524,720578..720702) III 1 NT_166530.1 Catalytic activity: trans-2,3-Didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-Tetradehydroacyl-CoA + NADPH.; Phenotype: Sps19 from S. cerevisiae is dispensable for growth and sporulation on solid acetate and oleate media, but is essential for these processes to occur on petroselineate.; Remark: ORF contains 1 frameshift, due to a putative sequencing error.; Remark: synonyms for Sps19 from S. cerevisiae are Spx19 and YNL202w.; Title: strong similarity to peroxisomal 2,4-dienoyl-CoA reductase involved in sporulation Sps19 -Saccharomyces cerevisiae [putative sequencing error]; peroxisome; See PMID 7969036; See PMID 9268358; See PMID 9427398; uncharacterized protein 720702 4987887 An15g02860 Aspergillus niger uncharacterized protein XP_001396824.1 719473 D 5061 CDS An15g02870 84593136 721230..723134 III 1 NT_166530.1 Similarity: the similarities are based on repetetive structures.; Title: similarity to Kaposis sarcoma-associated herpesvirus glycoprotein M - Herpesvirus 8; See PMID 9151804; uncharacterized protein 723134 84593136 An15g02870 Aspergillus niger uncharacterized protein XP_059602485.1 721230 D 5061 CDS An15g02880 4987889 join(723695..723931,724006..724944) III 1 NT_166530.1 Similarity: the ORF also shows strong similarity to the EST an_2290 from Aspergillus niger.; Similarity: the similarities are mainly based on repetetive structures.; Title: weak similarity to bZIP transcription factor L-Maf - Gallus gallus; uncharacterized protein 724944 4987889 An15g02880 Aspergillus niger uncharacterized protein XP_001396826.1 723695 D 5061 CDS An15g02890 4987890 join(725471..725581,725638..726553,726610..726961,727008..729258) III 1 NT_166530.1 Function: Mic1 from S. cerevisiae is an efficient GTPase-activating protein for Ypt6 and Sec4.; Remark: Mic1 from S. cerevisiae interacts with the transcription factor Mac1.; Remark: synonyms for Mic1 from S. cerevisiae are Mdr1, Gyp2 and YGR100w.; Title: strong similarity to GTPase-activating protein Mic1 - Saccharomyces cerevisiae; See PMID 10559187; uncharacterized protein 729258 4987890 An15g02890 Aspergillus niger uncharacterized protein XP_059602486.1 725471 D 5061 CDS An15g02900 4987891 complement(join(730196..730927,730981..731250,731318..735826)) III 1 NT_166530.1 Remark: ROM1 from S. cerevisiae is a GDP-GTP exchange protein (GEP) for the Rho1p SmallGTP-binding protein.; Remark: the predicted ORF seems approximately 600 aa longer than the found homologues.; Title: similarity to GDP/GTP exchange protein Rom1 -Saccharomyces cerevisiae; See PMID 8641285; uncharacterized protein 735826 4987891 An15g02900 Aspergillus niger uncharacterized protein XP_001396828.1 730196 R 5061 CDS An15g02910 84593137 complement(join(736954..737064,737185..737215,737262..737269)) III 1 NT_166530.1 Remark: the ORF is short in length (49 amino acids) and has an unusual exon/intron structure for A. niger.; Title: questionable ORF; uncharacterized protein 737269 84593137 An15g02910 Aspergillus niger uncharacterized protein XP_059602487.1 736954 R 5061 CDS An15g02920 84593138 complement(join(738028..738123,738309..738440)) III 1 NT_166530.1 hypothetical protein 738440 84593138 An15g02920 Aspergillus niger hypothetical protein XP_059602488.1 738028 R 5061 CDS An15g02930 4987894 join(738684..739261,739348..740860,740966..742459,742510..742973,743028..743451) III 1 NT_166530.1 Remark: CDR4 seems to be involved in fluconazole resistance in C. albicans.; Title: strong similarity to ABC transporter CDR4 -Candida albicans; See PMID 9767132; uncharacterized protein 743451 4987894 An15g02930 Aspergillus niger uncharacterized protein XP_001396831.1 738684 D 5061 CDS An15g02940 84593139 join(743905..744000,744073..744228,744334..744426,744516..744623) III 1 NT_166530.1 hypothetical protein 744623 84593139 An15g02940 Aspergillus niger hypothetical protein XP_059602489.1 743905 D 5061 CDS An15g02950 84593140 join(745133..745273,745324..745594,745808..746181) III 1 NT_166530.1 hypothetical protein 746181 84593140 An15g02950 Aspergillus niger hypothetical protein XP_059602490.1 745133 D 5061 CDS An15g02960 4987897 join(746395..746471,746614..747997) III 1 NT_166530.1 Title: similarity to hypothetical protein CAD37071.1 - Neurospora crassa; uncharacterized protein 747997 4987897 An15g02960 Aspergillus niger uncharacterized protein XP_059602491.1 746395 D 5061 CDS An15g02970 84593141 complement(join(749354..749569,749641..749676)) III 1 NT_166530.1 hypothetical protein 749676 84593141 An15g02970 Aspergillus niger hypothetical protein XP_059602492.1 749354 R 5061 CDS An15g02980 4987899 join(750388..750865,750936..751417,751470..751532) III 1 NT_166530.1 Catalytic activity: 1-CARBOXYVINYL CARBOXYPHOSPHONATE = 3-(HYDROHYDROXYPHOSPHORYL)PYRUVATE + CO(2).; Function: the Streptomyces hygroscopicus homolog BCPA catalyzes the formation of an unusual C-P bond that is involved in the biosynthesis of the antibiotic bialaphos (BA). BCPA catalyzes the rearrangement of the carboxyphosphono group of CPEP to form the C-P bond of phosphoenolpyruvate.; Pathway: Bialaphos biosynthesis pathway (BAP).; Title: strong similarity to carboxyphosphonoenolpyruvate mutase bcpA - Streptomyces hygroscopicus; uncharacterized protein 751532 4987899 An15g02980 Aspergillus niger uncharacterized protein XP_001396836.1 750388 D 5061 CDS An15g02990 4987900 join(752303..752320,752397..753125) III 1 NT_166530.1 Catalytic activity: S-adenosyl-L-methionine + catechol <=> S-adenosyl-L-homocysteine + guaiacol.; Function: the murine homolog COMT is a Mg2+-dependent enzyme which catalyses the transfer of methyl groups from S-adenosyl methionine to a hydroxyl group of a catecholic substrate. It converts, and thereby inactivates, dopamine to 3-methoxytyramine and norepinephrine to noemetanephrine.; Remark: COMT also shortens the biological half-lives of certain neuroactive drugs, like L-dopa, alpha-methyl dopa and isoproterenol.; Title: strong similarity to catechol-O-methyltransferase COMT from patent WO9832878-A1 - Mus sp.; uncharacterized protein 753125 4987900 An15g02990 Aspergillus niger uncharacterized protein XP_001396837.3 752303 D 5061 CDS An15g03000 84593142 complement(join(753411..753458,753538..753645)) III 1 NT_166530.1 hypothetical protein 753645 84593142 An15g03000 Aspergillus niger hypothetical protein XP_059602493.1 753411 R 5061 CDS An15g03010 4987902 join(753673..753674,753903..754025,754106..754506,754680..754729) III 1 NT_166530.1 Title: strong similarity to hypothetical protein B7F18.180 - Neurospora crassa; uncharacterized protein 754729 4987902 An15g03010 Aspergillus niger uncharacterized protein XP_059602494.1 753673 D 5061 CDS An15g03020 4987903 complement(join(754860..755405,755487..755706,755770..755808,755866..755891)) III 1 NT_166530.1 Complex: the P. patens RPN10 is part of the 26S proteasome, the primary protease of the ubiquitin-mediated proteolytic system in eukaryotes.; Function: the P. patens RPN10 has affinity for multiubiquitin chains in vitro and as a result may function as a receptor for ubiquitinated substrates.; Phenotype: the disruption of the rpn10 gene in P. patens shows strains which are viable but are under developmental arrest, generating abnormal caulonema that are unable to form buds and gametophores.; Title: strong similarity to proteasome 19S regulatory particle multiubiquitin chain binding subunit RPN10 - Physcomitrella patens; See PMID 10449580; uncharacterized protein 755891 4987903 An15g03020 Aspergillus niger uncharacterized protein XP_001396840.1 754860 R 5061 CDS An15g03030 4987904 join(756312..756459,756512..756803,756871..757594) III 1 NT_166530.1 Title: strong similarity to hypothetical protein B7F18.200 - Neurospora crassa; uncharacterized protein 757594 4987904 An15g03030 Aspergillus niger uncharacterized protein XP_001396841.1 756312 D 5061 CDS An15g03040 4987905 complement(join(759122..759577,759633..759919,759980..761077,761154..761798,761867..762569,762626..762862)) III 1 NT_166530.1 Remark: Note that in the older literature, some RING-fingers are denoted as LIM-domains. The LIM-domain Zn-finger is a fundamentally different family, albeit with similar Cys-spacing.; Title: strong similarity to hypothetical LIM domain protein - Schizosaccharomyces pombe; uncharacterized protein 762862 4987905 An15g03040 Aspergillus niger uncharacterized protein XP_001396842.3 759122 R 5061 CDS An15g03050 84593143 join(763532..763623,763747..763993,764084..764153,764239..764285) III 1 NT_166530.1 hypothetical protein 764285 84593143 An15g03050 Aspergillus niger hypothetical protein XP_059602495.1 763532 D 5061 CDS An15g03060 84593144 join(764717..764813,764901..765447,765552..765622,765711..765751) III 1 NT_166530.1 hypothetical protein 765751 84593144 An15g03060 Aspergillus niger hypothetical protein XP_059602496.1 764717 D 5061 CDS An15g03070 84593145 join(766017..766318,766413..766523,766681..766777) III 1 NT_166530.1 hypothetical protein 766777 84593145 An15g03070 Aspergillus niger hypothetical protein XP_059602497.1 766017 D 5061 CDS An15g03080 4987909 join(767018..767349,767483..767651,767708..768570,768721..768859) III 1 NT_166530.1 Function: E2 enzymes/ubc's in general catalyse the covalent attachment of ubiquitin to other target proteins or ubiquitin itself.; Golgi; Similarity: contains a domain typically for ubiquitin conjugating enzymes E2/ubc's. So does the A. thaliana homolog MJK13.; Similarity: the ORF shows similarity to a C-terminal region of M musculus BRUCE protein, but not to the N-terminally located baculovirus inhibitor of apoptosis repeat (BIR) motif.; Title: similarity to BIR repeat containing ubiquitin-conjugating enzyme BRUCE - Mus musculus; uncharacterized protein 768859 4987909 An15g03080 Aspergillus niger uncharacterized protein XP_059602498.1 767018 D 5061 CDS An15g03090 4987910 join(769282..769857,769917..770579) III 1 NT_166530.1 Catalytic activity: 3-beta-hydroxy-4-alpha-methyl-5-alpha-cholest-7-ene-4-beta -carboxylate + NAD(+) <=> 4-alpha-methyl-5-alpha-cholest-7-en-3-one + CO(2) + NADH.; Function: the C. albicans homolog ERG26 is a C-3 sterol dehydrogenase/C-4 decarboxylase; Pathway: C. albicans ERG26 is involved in ergosterol biosynthesis.; Title: strong similarity to C-3 sterol dehydrogenase/C-4 decarboxylase ERG26 - Candida albicans; uncharacterized protein 770579 4987910 An15g03090 Aspergillus niger uncharacterized protein XP_001396847.1 769282 D 5061 CDS An15g03100 4987911 join(771910..772355,772520..773402,773528..773957,774011..774057) III 1 NT_166530.1 Catalytic activity: the A. parasiticus homolog versicolorin B synthase vsb catalyzes the side chain cyclization of racemic versiconal hemiacetal to the bisfuran ring system of(-)-versicolorin B.; Function: aflatoxin B1 is a potent environmental carcinogen produced by certain strains of Aspergillus. Central to the biosynthesis of this mycotoxin is the reaction catalyzed by versicolorin B synthase vbs.; Pathway: aflatoxin biosynthetic pathway.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Title: strong similarity to versicolorin B synthase vbs - Aspergillus parasiticus; See PMID 8662689; uncharacterized protein 774057 4987911 An15g03100 Aspergillus niger uncharacterized protein XP_059602499.1 771910 D 5061 CDS An15g03110 84593146 join(774969..775039,775183..775311,775407..775466,775566..775641,776005..776079) III 1 NT_166530.1 hypothetical protein 776079 84593146 An15g03110 Aspergillus niger hypothetical protein XP_059602500.1 774969 D 5061 CDS An15g03120 84593147 join(776186..776206,776241..776322,776442..776549,776635..776738,776815..777001,777151..777255,777339..777820,777890..777949) III 1 NT_166530.1 hypothetical protein 777949 84593147 An15g03120 Aspergillus niger hypothetical protein XP_059602501.1 776186 D 5061 CDS An15g03130 84593148 complement(join(778046..778201,778683..778865,779084..779159,779320..779429)) III 1 NT_166530.1 hypothetical protein 779429 84593148 An15g03130 Aspergillus niger hypothetical protein XP_059602502.1 778046 R 5061 CDS An15g03140 4987915 join(779543..780109,780179..785788) III 1 NT_166530.1 Function: overexpression of S. pombe CEK1 complements a fission yeast mutation that blocks anaphase.; Remark: the S. pombe homolog CEK1 is significantly shorter.; Title: similarity to protein kinase cek1p -Schizosaccharomyces pombe; uncharacterized protein 785788 4987915 An15g03140 Aspergillus niger uncharacterized protein XP_001396852.1 779543 D 5061 CDS An15g03150 4987916 complement(join(787333..789498,789562..790200)) III 1 NT_166530.1 Title: strong similarity to hypothetical protein SPCC1183.11 - Schizosaccharomyces pombe; uncharacterized protein 790200 4987916 An15g03150 Aspergillus niger uncharacterized protein XP_001396853.1 787333 R 5061 CDS An15g03160 84593149 join(790581..790642,790671..790863) III 1 NT_166530.1 hypothetical protein 790863 84593149 An15g03160 Aspergillus niger hypothetical protein XP_059602503.1 790581 D 5061 CDS An15g03170 84593150 join(791053..791180,791277..791324,791404..791475,791565..791826) III 1 NT_166530.1 hypothetical protein 791826 84593150 An15g03170 Aspergillus niger hypothetical protein XP_059602504.1 791053 D 5061 CDS An15g03180 84593151 join(792141..792153,792246..792444,792827..793040) III 1 NT_166530.1 hypothetical protein 793040 84593151 An15g03180 Aspergillus niger hypothetical protein XP_059602505.1 792141 D 5061 CDS An15g03190 4987920 join(793374..793385,793541..793599,793682..793835,793896..793983,794034..794105,794166..794669,794738..795204) III 1 NT_166530.1 Complex: the E. nidulans homolog tubB encodes one of two alpha-tubulin isoforms that are required for microtubule formation.; Function: Microtubules are polymers that are essential for, among other functions, cell transport and cell division in all eukaryotes. Gamma-tubulin is necessary to initiate the assembly of alpha-beta tubulin heterodimers into microtubule polymers.; Title: strong similarity to hypothetical tubulin alpha-2 chain tubB - Aspergillus nidulans; uncharacterized protein 795204 4987920 An15g03190 Aspergillus niger uncharacterized protein XP_001396857.1 793374 D 5061 CDS An15g03200 4987921 complement(join(795533..796412,796481..796533,796667..796699)) III 1 NT_166530.1 Function: the H. sapiens homolog MUP1 is a mitochondrial deoxynucleotide carrier (TC 2. A. 29). Its physiological role is probably to supply deoxynucleotides to the mitochondrial matrix for conversion to triphosphates and incorporation into mitochondrial DNA.; Title: strong similarity to mitochondrial uncoupling protein MUP1 from patent WO200061614-A2 - Homo sapiens; localisation:mitochondrion; See PMID 11226231; uncharacterized protein 796699 4987921 An15g03200 Aspergillus niger uncharacterized protein XP_001396858.1 795533 R 5061 CDS An15g03210 4987922 797395..799026 III 1 NT_166530.1 Catalytic activity: H. sapiens BBH converts gamma-butyrobetaine (4-trimethylammoniobutanoate),alpha-ketoglutarate and molecular oxygen into carnitine (3-hydroxy-4-trimethylammoniobutanoate), succinate and CO2; Function: the H. sapiens homolog gamma-butyrobetaine hydroxylase BBH is a alpha-ketoglutarate-dependent dioxygenase. It mediates the last step in carnitine biosynthesis and uses iron (2+) and ascorbate as co-factors.; Remark: gamma-butyrobetaine hydroxylase is inhibited by MET-88, 3-(2,2,2-trimethylhydrazinium) propionate.; Title: strong similarity to gamma-butyrobetaine hydroxylase BBH - Homo sapiens; uncharacterized protein 799026 4987922 An15g03210 Aspergillus niger uncharacterized protein XP_001396859.1 797395 D 5061 CDS An15g03220 4987923 complement(join(799482..799550,799622..800374)) III 1 NT_166530.1 Similarity: shows strong similarity to thioredoxin superfamily.; Title: strong similarity to member of the subfamily of yeast glutaredoxins Grx4 - Saccharomyces cerevisiae; See PMID 10567543; uncharacterized protein 800374 4987923 An15g03220 Aspergillus niger uncharacterized protein XP_001396860.1 799482 R 5061 CDS An15g03230 4987924 join(801183..801603,801721..802086,802165..803353,803444..803552,803608..803928) III 1 NT_166530.1 Title: strong similarity to hypothetical exonuclease - Schizosaccharomyces pombe; uncharacterized protein 803928 4987924 An15g03230 Aspergillus niger uncharacterized protein XP_059602506.1 801183 D 5061 CDS An15g03240 4987925 complement(join(804065..805556,805619..805911)) III 1 NT_166530.1 Title: weak similarity to hypothetical retrotransposon protein AAK72287.1 - Oryza sativa; uncharacterized protein 805911 4987925 An15g03240 Aspergillus niger uncharacterized protein XP_001396862.1 804065 R 5061 CDS An15g03250 84593152 join(806373..806453,806542..806691) III 1 NT_166530.1 hypothetical protein 806691 84593152 An15g03250 Aspergillus niger hypothetical protein XP_059602507.1 806373 D 5061 CDS An15g03260 4987927 join(807434..807515,807588..808579) III 1 NT_166530.1 Catalytic activity: the threonin aldolase converts L-threonine to glycine and acetaldehyde.; Remark: riboflavin production in the filamentous fungus Ashbya gossypii is limited by glycine and is enhanced by activation of the threonin aldolase.; Remark: the A. gossypii gly1 gene encoding the threonine aldolase was isolated by heterologous complementation of the glycine-auxotrophic S. cerevisiae strain YM13 with a genomic library from A. gossypii.; Title: strong similarity to threonine aldolase -Ashbya gossypii; See PMID 9797278; uncharacterized protein 808579 4987927 An15g03260 Aspergillus niger uncharacterized protein XP_001396864.3 807434 D 5061 CDS An15g03270 84593153 complement(join(808854..809028,809191..809393,809530..809667)) III 1 NT_166530.1 hypothetical protein 809667 84593153 An15g03270 Aspergillus niger hypothetical protein XP_059602508.1 808854 R 5061 CDS An15g03280 4987929 join(809885..810727,810786..811186,811235..812984) III 1 NT_166530.1 Catalytic activity: Rad53p phosphorylates proteins on serine, threonine, and tyrosine.; Function: S. cerevisiae Rad53p is required for DNA damage-induced checkpoint arest in G1, S/M, and G2/M in mitosis. It is dispensable for sporulation but required for wild-type spore viability.; Induction: S. cerevisiae Mec1p and Tel1p regulate Rad53p phosphorylation.; Remark: alternative gene names for the S. cerevisiae homolog RAD53 are LSD1, MEC2 and SPK1.; Title: strong similarity to protein kinase RAD53 from patent US5674996-A - Saccharomyces cerevisiae; uncharacterized protein 812984 4987929 An15g03280 Aspergillus niger uncharacterized protein XP_001396866.3 809885 D 5061 CDS An15g03290 84593154 complement(join(813654..813809,813889..813938,814029..814089)) III 1 NT_166530.1 hypothetical protein 814089 84593154 An15g03290 Aspergillus niger hypothetical protein XP_059602509.1 813654 R 5061 CDS An15g03300 4987931 815632..816075 III 1 NT_166530.1 hypothetical protein 816075 4987931 An15g03300 Aspergillus niger hypothetical protein XP_001396868.1 815632 D 5061 CDS An15g03310 84593155 join(818070..818127,818195..818311,818415..818494) III 1 NT_166530.1 hypothetical protein 818494 84593155 An15g03310 Aspergillus niger hypothetical protein XP_059602510.1 818070 D 5061 CDS An15g03320 84593156 complement(join(819105..819183,819255..819368,819460..819557)) III 1 NT_166530.1 hypothetical protein 819557 84593156 An15g03320 Aspergillus niger hypothetical protein XP_059602511.1 819105 R 5061 CDS An15g03330 4987934 join(819700..820135,820193..820478,820528..821191) III 1 NT_166530.1 Catalytic activity: Bed1p is a alpha-1,6-mannosyltransferase.; Complex: Bed1p, Anp1p, Mnn9p, Mnn11p, and Hoc1p are subunits of the same complex.; Function: S. cerevisiae Bed1p gene is a component of one of two complexes in the cis-Golgi, which elongates the alpha-1,6-linked mannose backbone of many cell wall proteins in yeast. Bed1p/Mnn10p and Mnn11p are responsible for the majority of the alpha-1, 6- polymerizing activity of the complex.; Title: strong similarity to galactosyltransferase Bed1 - Saccharomyces cerevisiae; uncharacterized protein 821191 4987934 An15g03330 Aspergillus niger uncharacterized protein XP_001396871.3 819700 D 5061 CDS An15g03340 4987935 join(821724..821949,822069..822163) III 1 NT_166530.1 Similarity: the ORF shows strong similarity to expressed sequence tag seq id no:3902 of patent WO200056762-A2 from Aspergillus niger.; Title: strong similarity to hypothetical protein NUO-12.3 - Neurospora crassa; uncharacterized protein 822163 4987935 An15g03340 Aspergillus niger uncharacterized protein XP_001396872.1 821724 D 5061 CDS An15g03350 4987936 complement(join(822541..822798,822850..824142)) III 1 NT_166530.1 Function: the E. nidulans homolog PalC participates in regulation of gene expression by ambient (extracellular) pH.; Pathway: the E. nidulans palA, B, C, F, H, and I genes encode components of an ambient pH signal transduction pathway which regulates the zinc finger transcription factor pacC.; Title: strong similarity to palC - Aspergillus nidulans; uncharacterized protein 824142 4987936 An15g03350 Aspergillus niger uncharacterized protein XP_001396873.3 822541 R 5061 CDS An15g03360 4987937 complement(824732..825379) III 1 NT_166530.1 Remark: TAF47 S. cerevisiae is a TAF(II) complex (TBP-associated protein complex) component.; Remark: also similarity to Yeast transcriptional activator factor TAF-47 protein patent WO9749828-A.; Remark: alternate name is YPL011c.; Title: similarity to component of the TBP-associated protein complex Taf47 - Saccharomyces cerevisiae; See PMID 9845373; uncharacterized protein 825379 4987937 An15g03360 Aspergillus niger uncharacterized protein XP_001396874.1 824732 R 5061 CDS An15g03370 4987938 join(825743..826775,826893..827224) III 1 NT_166530.1 Remark: ptr6, causes accumulation of mRNA in the nucleus and inhibition of growth at the nonpermissive temperature. Ptr6p is required for mRNA transport and is a Schizosaccharomyces pombe homologue of yTAFII67 and hTAFII55.; Title: strong similarity to subunit of transcription initiation factor TFIID ptr6p - Schizosaccharomyces pombe; nucleus; See PMID 10388808; uncharacterized protein 827224 4987938 An15g03370 Aspergillus niger uncharacterized protein XP_059602512.1 825743 D 5061 CDS An15g03380 4987939 complement(join(827318..827338,827376..827978)) III 1 NT_166530.1 hypothetical protein 827978 4987939 An15g03380 Aspergillus niger hypothetical protein XP_001396876.3 827318 R 5061 CDS An15g03390 4987940 join(828913..829232,829301..829805) III 1 NT_166530.1 Remark: strong similarity to Arabidopsis thaliana protein fragment SEQ ID NO: 38749 patent EP1033405-A2.; Similarity: belongs to enoyl-CoA hydratases family.; Title: strong similarity to protein fragment SEQ ID NO:38749 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 829805 4987940 An15g03390 Aspergillus niger uncharacterized protein XP_001396877.1 828913 D 5061 CDS An15g03400 4987941 join(830746..831082,831119..831150) III 1 NT_166530.1 hypothetical protein 831150 4987941 An15g03400 Aspergillus niger hypothetical protein XP_059602513.1 830746 D 5061 CDS An15g03410 4987942 complement(831733..832515) III 1 NT_166530.1 Title: weak similarity to hypothetical protein B12J7.240 - Neurospora crassa; uncharacterized protein 832515 4987942 An15g03410 Aspergillus niger uncharacterized protein XP_001396879.1 831733 R 5061 CDS An15g03420 4987943 join(833222..833385,833452..834866,834996..835258) III 1 NT_166530.1 Remark: similarity to EST an_0838 Aspergillus niger.; Title: strong similarity to hypothetical protein YER049w - Saccharomyces cerevisiae; uncharacterized protein 835258 4987943 An15g03420 Aspergillus niger uncharacterized protein XP_059602514.1 833222 D 5061 CDS An15g03430 84593157 join(835983..836027,836100..836133,836167..836197,836314..836392,836434..836469) III 1 NT_166530.1 hypothetical protein 836469 84593157 An15g03430 Aspergillus niger hypothetical protein XP_059602515.1 835983 D 5061 CDS An15g03440 84593158 join(837265..837276,837358..837518,837589..837630,837719..837860,837977..838075) III 1 NT_166530.1 hypothetical protein 838075 84593158 An15g03440 Aspergillus niger hypothetical protein XP_059602516.1 837265 D 5061 CDS An15g03450 84593159 join(838579..838638,838757..838866,838981..839097,839182..839315,839491..839690,839794..839899,840150..840377,840460..840522,840614..840668,841004..841104,841190..841321,841413..841543,841717..841754,841805..841924,842186..842240) III 1 NT_166530.1 Title: similarity to EST an_0903 - Aspergillus niger; uncharacterized protein 842240 84593159 An15g03450 Aspergillus niger uncharacterized protein XP_059602517.1 838579 D 5061 CDS An15g03460 84593160 complement(join(842299..842376,842425..842586,842627..842722,842904..843057,843152..843281,843385..843586)) III 1 NT_166530.1 hypothetical protein 843586 84593160 An15g03460 Aspergillus niger hypothetical protein XP_059602518.1 842299 R 5061 CDS An15g03470 84593161 complement(join(844094..844384,844539..844604,844964..845093,845845..845989,846110..846170)) III 1 NT_166530.1 hypothetical protein 846170 84593161 An15g03470 Aspergillus niger hypothetical protein XP_059602519.1 844094 R 5061 CDS An15g03480 84593162 complement(join(846892..847030,847115..847146,847226..847282)) III 1 NT_166530.1 hypothetical protein 847282 84593162 An15g03480 Aspergillus niger hypothetical protein XP_059602520.1 846892 R 5061 CDS An15g03490 10098192 join(847606..848611,848668..848907,848974..849286,849588..849828,849891..849979,850030..850343,850729..850951,850991..855021,855250..855290) III 1 NT_166530.1 Title: strong similarity to hypothetical bHLH transcription factor hpa3 - Aspergillus nidulans; uncharacterized protein 855290 10098192 An15g03490 Aspergillus niger uncharacterized protein XP_059602521.1 847606 D 5061 CDS An15g03500 4987951 complement(855709..856488) III 1 NT_166530.1 Title: weak similarity to hypothetical protein AAP68395.1 - Oryza sativa; uncharacterized protein 856488 4987951 An15g03500 Aspergillus niger uncharacterized protein XP_001396888.1 855709 R 5061 CDS An15g03510 84593163 complement(join(856668..856800,856862..857019,857096..857188)) III 1 NT_166530.1 hypothetical protein 857188 84593163 An15g03510 Aspergillus niger hypothetical protein XP_059602522.1 856668 R 5061 CDS An15g03520 84593164 complement(join(857309..857422,857653..857724,857837..857926)) III 1 NT_166530.1 hypothetical protein 857926 84593164 An15g03520 Aspergillus niger hypothetical protein XP_059602523.1 857309 R 5061 CDS An15g03530 4987954 join(858058..858519,858597..859860,859918..860294) III 1 NT_166530.1 Catalytic activity: a dinucleotide + H2O = 2 mononucleotide; hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.; Function: human PC-1 is an ecto-enzyme possessing alkaline phosphodiesterase I and nucleotide pyrophosphatase activities.; Pathway: purine metabolism; starch and sucrose metabolism; riboflavin metabolism; nicotinate and nicotinamide metabolism; pantothenate and CoA biosynthesis.; Remark: he murine cell membrane glycoprotein PC-1 is a homodimer with restricted tissue distribution, being first characterized in plasma cells. In situ chromosomal hybridization localizes the gene for human PC-1 to chromosome 6q22-q23, a common site for deletions in human lymphoid neoplasia.; Similarity: belongs to the nucleotide pyrophosphatases.; Title: strong similarity to plasma cell membrane glycoprotein PC-1 - Homo sapiens; See PMID 1315502; See PMID 2211644; See PMID 8001561; uncharacterized protein 860294 4987954 An15g03530 Aspergillus niger uncharacterized protein XP_001396891.1 858058 D 5061 CDS An15g03540 4987955 join(861062..862819,862910..862951) III 1 NT_166530.1 Remark: respiratory deficient pet mutants of S. cerevisiae assigned to complementation group G2 define a gene, named BCS1, whose product is shown to be necessary for the expression of functional ubiquinol-cytochrome c reductase (bc1) complex. The BCS1 protein is anchored in the mitochondrial inner membrane via a single transmembrane domain and has an N(out)-C(in) topology. Unlike the majority of nuclear encoded mitochondrial preproteins, the BCS1 protein does not contain an N-terminal targeting sequence.; Title: strong similarity to protein precursor Bcs1 -Saccharomyces cerevisiae; See PMID 1327750; See PMID 8599931; uncharacterized protein 862951 4987955 An15g03540 Aspergillus niger uncharacterized protein XP_001396892.3 861062 D 5061 CDS An15g03550 4987956 complement(join(863389..863475,863538..864206)) III 1 NT_166530.1 Title: weak similarity to protopectinase from patent WO9806832-A1 - Bacillus subtilis; uncharacterized protein 864206 4987956 An15g03550 Aspergillus niger uncharacterized protein XP_059602524.1 863389 R 5061 CDS An15g03560 84593165 join(864442..864631,864751..864837,865290..865436,865506..865655,865721..865917,866115..866186,866267..866440,866515..866640) III 1 NT_166530.1 hypothetical protein 866640 84593165 An15g03560 Aspergillus niger hypothetical protein XP_059602525.1 864442 D 5061 CDS An15g03570 4987958 complement(join(866888..867820,867888..868283)) III 1 NT_166530.1 Remark: similarity to human secreted protein sequence SEQ ID NO:154 patent WO200004140-A1.; Title: similarity to secreted protein SEQ ID NO:154 from patent WO200004140-A1 - Homo sapiens; uncharacterized protein 868283 4987958 An15g03570 Aspergillus niger uncharacterized protein XP_001396895.1 866888 R 5061 CDS An15g03580 4987959 complement(join(869365..874229,874313..874370)) III 1 NT_166530.1 Function: mouse KIF1B works as a monomeric motor for anterograde transport of mitochondria.; Remark: KIF1B is expressed ubiquitously in various kinds of tissues. In situ hybridization revealed that KIF1B is expressed abundantly in differentiated nerve cells.; Remark: also strong similarity to Thermomyces lanuginosus kinesin motor protein TL-gamma patent WO9937659-A1 but this protein is only 784 amino acis in lenght.; Title: strong similarity to kinesin-like protein KIF1B - Mus musculus; See PMID 7528108; uncharacterized protein 874370 4987959 An15g03580 Aspergillus niger uncharacterized protein XP_059602526.1 869365 R 5061 CDS An15g03590 84593166 complement(join(874675..874992,875313..875401,875443..875538,875631..875763,875830..875913)) III 1 NT_166530.1 hypothetical protein 875913 84593166 An15g03590 Aspergillus niger hypothetical protein XP_059602527.1 874675 R 5061 CDS An15g03600 84593167 complement(join(877021..877541,877714..877765)) III 1 NT_166530.1 hypothetical protein 877765 84593167 An15g03600 Aspergillus niger hypothetical protein XP_059602528.1 877021 R 5061 CDS An15g03610 84593168 complement(join(878065..878115,878228..878324,878374..878546)) III 1 NT_166530.1 hypothetical protein 878546 84593168 An15g03610 Aspergillus niger hypothetical protein XP_059602529.1 878065 R 5061 CDS An15g03620 84593169 complement(join(878600..878778,878866..878947,879047..879101,879279..879350,879494..879651)) III 1 NT_166530.1 hypothetical protein 879651 84593169 An15g03620 Aspergillus niger hypothetical protein XP_059602530.1 878600 R 5061 CDS An15g03630 84593170 join(881195..881228,881320..881437,881681..>881813) III 1 NT_166530.1 Remark: C-terminal truncated ORF due to end of contig.; hypothetical protein [truncated ORF] 881813 84593170 An15g03630 Aspergillus niger hypothetical protein [truncated ORF] XP_059602531.1 881195 D 5061 CDS An15g03640 84593171 complement(join(882529..882779,882857..882962,883179..883239,883384..883467,883652..883718,883769..883811,883905..883984,884052..884247)) III 1 NT_166530.1 hypothetical protein 884247 84593171 An15g03640 Aspergillus niger hypothetical protein XP_059606475.1 882529 R 5061 CDS An15g03650 4987966 884538..885656 III 1 NT_166530.1 Complex: the HapB, HapC and HapE proteins of A. nidulans form the complex AnCF, which binds to the CCAAT sequence in the amdS promoter of Aspergillus nidulans.; Function: in A. nidulans, AnCF regulates positively the expression of the amdS gene (encoding acetamidase) and two penicillin biosynthesis genes (ipnA and aatA). in A. nidulans, AnCF negatively regulates the expression of lysF,which encodes homoaconitase.; Phenotype: A. nidulans strains with deletions of each of the hapB, hapC, and hapE genes have identical phenotypes of slow growth, poor conidiation, and reduced expression of amdS.; Regulation: the A. nidulans multimeric CCAAT binding complex AnCF is negatively autoregulated via its hapB subunit gene, which contains two inversely oriented,conserved CCAAT boxes (box alpha and box beta).; Similarity: the predicted A. niger protein shows strong similarity to the HapB protein of A. nidulans. a domain of approximately 65 amino acids is conserved in fungal, plant and vertebrate species.; Title: strong similarity to protein hapB -Aspergillus nidulans; nucleus; See PMID 9858535; See PMID 11243777; See PMID 11285740; uncharacterized protein 885656 4987966 An15g03650 Aspergillus niger uncharacterized protein XP_001396903.3 884538 D 5061 CDS An15g03660 84593172 complement(join(886089..886269,886347..886606,886685..886736,886809..887021,887101..887181,887293..887507,887627..887695,887989..888074,888178..888304)) III 1 NT_166530.1 hypothetical protein 888304 84593172 An15g03660 Aspergillus niger hypothetical protein XP_059606476.1 886089 R 5061 CDS An15g03670 4987968 join(888385..888487,888575..890589,890642..891274) III 1 NT_166530.1 Remark: a splice site was detected upstream of the START codon.; Title: similarity to hypothetical C2H2-type zinc-finger protein - Schizosaccharomyces pombe; uncharacterized protein 891274 4987968 An15g03670 Aspergillus niger uncharacterized protein XP_001396905.1 888385 D 5061 CDS An15g03680 4987969 complement(join(891515..891745,891778..891936,892100..893176)) III 1 NT_166530.1 Title: similarity to hypothetical protein CAC86582.1 - Podospora anserina; uncharacterized protein 893176 4987969 An15g03680 Aspergillus niger uncharacterized protein XP_001396906.3 891515 R 5061 CDS An15g03690 84593173 join(893810..894147,894239..894355,894508..894567,894658..894738,894827..895223) III 1 NT_166530.1 hypothetical protein 895223 84593173 An15g03690 Aspergillus niger hypothetical protein XP_059606477.1 893810 D 5061 CDS An15g03700 84593174 join(896576..896605,896720..897280) III 1 NT_166530.1 hypothetical protein 897280 84593174 An15g03700 Aspergillus niger hypothetical protein XP_059606478.1 896576 D 5061 CDS An15g03710 4987972 join(897682..897763,898109..898189,898249..898336,898399..898947,899003..899465) III 1 NT_166530.1 Title: weak similarity to hypothetical transcription regulator meaB - Aspergillus nidulans; See PMID 8690087; uncharacterized protein 899465 4987972 An15g03710 Aspergillus niger uncharacterized protein XP_001396909.1 897682 D 5061 CDS An15g03720 4987973 complement(join(899763..899792,899827..899844,899952..900278,900333..900413)) III 1 NT_166530.1 Remark: Hap1 of S. cerevisiae binds to two classes of DNA elements, UAS1/CYC1 and UAS/CYC7, and permits differential transcriptional activation at these sites. in yeast, oxygen sensing and heme signaling are primarily mediated by the heme activator protein Hap1, which, in response to heme, activates the transcription of genes required for respiration and for controlling oxidative damage.; Similarity: the predicted A. niger protein shows weak similarity to the CYC1/CYP3/HAP1 transcription activator of S. cerevisiae which belongs to the unassigned GAL4-type zinc cluster proteins.; Title: weak similarity to CYC1/CYP3 transcription activator Hap1 - Saccharomyces cerevisiae; See PMID 10617612; See PMID 11212295; See PMID 2643482; uncharacterized protein 900413 4987973 An15g03720 Aspergillus niger uncharacterized protein XP_001396910.3 899763 R 5061 CDS An15g03730 4987974 complement(901116..902195) III 1 NT_166530.1 Similarity: the predicted A. niger protein shows strong similarity to hypothetical proteins of several procaryotic species.; Title: strong similarity to hypothetical 41.5 kD protein of cosmid clone 65G3 - Zymomonas mobilis; uncharacterized protein 902195 4987974 An15g03730 Aspergillus niger uncharacterized protein XP_001396911.1 901116 R 5061 CDS An15g03740 4987975 join(902628..902886,902933..903651) III 1 NT_166530.1 Function: A. parasiticus adhA catalyses the conversion of 5'-hydroxyaverantin (HAVN) to 5'-ketoaverantin, the open-chain form of averufin (AVF) in the synthesis of aflatoxin.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Similarity: the protein shows strong similarity to several mammalian NAD+-dependent 15-hydroxyprostaglandin dehydrogenases.; Title: similarity to short-chain alcohol dehydrogenase adhA - Aspergillus parasiticus; See PMID 11055914; uncharacterized protein 903651 4987975 An15g03740 Aspergillus niger uncharacterized protein XP_059606479.1 902628 D 5061 CDS An15g03750 4987976 join(904434..904440,904532..906150) III 1 NT_166530.1 Remark: the patent does not provide further information about the function of the protein.; Similarity: the predicted A. niger protein shows similarity to the adhesion protease of patent WO0109293-A/1 of H. sapiens (AC# CAC33153) and strong similarity to probable zinc metallopeptidase of S. pombe.; Title: similarity to adhesion protease from patent WO0109293-A - Homo sapiens; uncharacterized protein 906150 4987976 An15g03750 Aspergillus niger uncharacterized protein XP_059606480.1 904434 D 5061 CDS An15g03760 4987977 join(906491..906644,906695..907382,907540..907571,907805..908061) III 1 NT_166530.1 Title: weak similarity to hypothetical protein CAD21317.1 - Neurospora crassa; uncharacterized protein 908061 4987977 An15g03760 Aspergillus niger uncharacterized protein XP_059606481.1 906491 D 5061 CDS An15g03770 84593175 join(908867..909675,909814..909852,909882..909918) III 1 NT_166530.1 Catalytic activity: MR1 of M. ramanniana catalyses the reaction acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.; Function: MR1 of M. ramanniana is active in the formation of triacylglycerol from diacylglycerol and fatty acyl substrates.; Remark: the DNA sequence encoding MR1 of M. ramanniana can be used to modify the triacylglycerol and lipid composition of plant cells.; Similarity: the predicted A. niger protein shows strong similarity to the protein sequence diacylglycerol acyl transferase (MR1) of patent WO200001713-A2 (AC# AAY68640) of M. ramanniana.; Title: strong similarity to diacylglycerol acyl transferase MR1 from patent WO200001713-A2 - Mortierella ramanniana; uncharacterized protein 909918 84593175 An15g03770 Aspergillus niger uncharacterized protein XP_059606482.1 908867 D 5061 CDS An15g03780 4987979 complement(join(910042..911594,911660..911867)) III 1 NT_166530.1 Complex: Moe1 from S. pombe interacts with a Ras effector, Scd1 of S. pombe, Mal3 of S. pombe, which is a member of a conserved family of microtubule-binding proteins (includes human EB1 and budding yeast Bim1) and Yin6 of S. pombe, which is a homolog of the human breast cancer gene Int6.; Function: Moe1 from S. pombe is a negative regulator for microtubule dynamics which induces instabilty in microtubules and affects spindle formation.; Pathway: Moe1 from S. pombe is a component of the ras protooncogene mediated signal transduction pathway that regulates cell proliferation.; Phenotype: a moe1 null (Delta) mutant exhibits numerous phenotypes indicative of abnormal microtubule functioning, including an abnormality in the spindle. moe1Delta mutants are resistant to microtubule destabilizing agents; moreover, moe1Delta rescued the growth defects of tubulin mutants containing unstable microtubules.; Similarity: the predicted A. niger protein shows strong similarity to Moe1 from S. pombe and several hypothetical proteins from various eucaryotic organisms,which belong to the eIF3S7 family.; Title: strong similarity to ras pathway interacting protein moe1p - Schizosaccharomyces pombe; nucleus; See PMID 9892665; See PMID 11102508; See PMID 11121040; See PMID 11268035; uncharacterized protein 911867 4987979 An15g03780 Aspergillus niger uncharacterized protein XP_001396916.1 910042 R 5061 CDS An15g03790 84593176 join(912383..912646,912839..912917,912993..913168) III 1 NT_166530.1 hypothetical protein 913168 84593176 An15g03790 Aspergillus niger hypothetical protein XP_059606483.1 912383 D 5061 CDS An15g03800 4987981 join(913445..913733,913796..913857,913906..913947) III 1 NT_166530.1 Similarity: the nucleotide sequence of the ORF shows strong similarity to two ESTs of A. niger (an_3228 and an_3303).; Title: strong similarity to EST an_3228 -Aspergillus niger; uncharacterized protein 913947 4987981 An15g03800 Aspergillus niger uncharacterized protein XP_001396918.1 913445 D 5061 CDS An15g03810 4987982 complement(join(914373..914417,914470..914724,914798..914983)) III 1 NT_166530.1 Title: similarity to hypothetical protein mlr1783 -Mesorhizobium loti; uncharacterized protein 914983 4987982 An15g03810 Aspergillus niger uncharacterized protein XP_001396919.3 914373 R 5061 CDS An15g03820 4987983 complement(join(915381..915428,915492..915655,915721..916077,916233..916902,916955..917225,917286..917367,917421..917466)) III 1 NT_166530.1 Catalytic activity: an aromatic primary alcohol + O(2) <=> an aromatic aldehyde + H(2)O(2).; Function: a double bond conjugated with a primary alcohol is necessary for substrate recognition by P. eryngii aao, and that activity is increased by the presence of additional conjugated double bonds and electron donor groups.; Function: aao from P. eryngii is an extracellular enzyme and constitutes a source for H(2)O(2) required in lignin biodegradation.; Function: aao from P. eryngii presents wide specificity, showing activity on benzyl, cinnamyl, naphthyl and aliphatic unsaturated alcohols.; Title: strong similarity to aryl-alcohol oxidase precursor aao - Pleurotus pulmonarius; extracellular/secretion proteins; See PMID 10377251; See PMID 1425667; uncharacterized protein 917466 4987983 An15g03820 Aspergillus niger uncharacterized protein XP_059606484.1 915381 R 5061 CDS An15g03830 4987984 complement(join(918158..918922,918968..919061,919130..919545)) III 1 NT_166530.1 hypothetical protein 919545 4987984 An15g03830 Aspergillus niger hypothetical protein XP_059606485.1 918158 R 5061 CDS An15g03850 84593177 complement(join(920837..921165,921238..921334)) III 1 NT_166530.1 hypothetical protein 921334 84593177 An15g03850 Aspergillus niger hypothetical protein XP_059606486.1 920837 R 5061 CDS An15g03860 4987987 complement(join(<921903..922917,923076..923541,923718..924010,924075..924514,924565..924605,924704..924824,924883..925016)) III 1 NT_166530.1 Induction: transcription of the gabA gene of A. nidulans is activated by the transcription factor IntA.; Remark: a putative sequencing error results in an frameshift.; Remark: in A. niger GABA is used as a nitrogen source.; Remark: in agreement with the wealth of genetic data available, transcript level analyses demonstrate that gabA (A. nidulans) is subject to carbon catabolite and nitrogen metabolite repression, omega-amino acid induction and regulation in response to ambient pH (being acid-expressed).; Repression: transcription of the gabA gene of A. nidulans is repressed by the zinc finger transcription factor PacC.; Similarity: the predicted A. niger protein shows also similarity to several putative fungal aminoacid permeases.; Title: strong similarity to GABA permease gabA -Aspergillus nidulans [putative frameshift]; putative frameshift; See PMID 10320578; uncharacterized protein 925016 4987987 An15g03860 Aspergillus niger uncharacterized protein XP_059606487.1 921903 R 5061 CDS An15g03870 84593178 complement(join(925280..925582,925701..925770,925895..925952,926287..926360,926549..926694)) III 1 NT_166530.1 hypothetical protein 926694 84593178 An15g03870 Aspergillus niger hypothetical protein XP_059606488.1 925280 R 5061 CDS An15g03880 4987989 join(926888..927439,927559..927680,927733..927763,927800..927868) III 1 NT_166530.1 hypothetical protein 927868 4987989 An15g03880 Aspergillus niger hypothetical protein XP_059606489.1 926888 D 5061 CDS An15g03890 84593179 join(928566..928750,928844..928936,928953..929023,929135..929292) III 1 NT_166530.1 hypothetical protein 929292 84593179 An15g03890 Aspergillus niger hypothetical protein XP_059606490.1 928566 D 5061 CDS An15g03900 4987991 join(929501..929579,929638..929684,929752..929838,929896..930253,930571..931295) III 1 NT_166530.1 Function: Zinc-replete cells accumulate zinc in the vacuole via the Zrc1p (and Cot1p) transporters.; Localization: a Zrc1-GFP fusion protein is localized to the vacuolar membrane in S. cerevisiae.; Regulation: the Zap1p transcriptional activator of S. cerevisiae induces the expression of ZRC1 when the intracellular zinc level is decreased and this induction is repressed by zinc. Zap1p also activates zinc transporters of the ZIP family (Zrt1p, Zrt2p and Zrt3p).; Remark: ZRC1 from S. cerevisiae was initially identified as a gene conferring resistance to zinc and cadmium ions. the oxidative-stress-resistance (OSR) gene from S. cerevisiae, which enhances resistance against oxidative stress caused by lipid hydroperoxide, was isolated independently and found to be identical to ZRC1.; Similarity: the predicted A. niger protein shows strong similarity to heavy metal ion resistance protein ZRC1/OSD from S. cerevisiae and additional heavy metal ion transporting proteins from S. cerevisiae and other species. ZRC1 from S. cerevisiae belongs to the cation diffusion facilitator (CDF) family.; Title: strong similarity to heavy metal ion resistance protein Zrc1 - Saccharomyces cerevisiae; vacuole; See PMID 8867889; See PMID 10856230; See PMID 11027563; See PMID 11263974; See PMID 2693940; uncharacterized protein 931295 4987991 An15g03900 Aspergillus niger uncharacterized protein XP_059606491.1 929501 D 5061 CDS An15g03910 4987992 join(932043..932357,932434..934079,934169..934196) III 1 NT_166530.1 Remark: CDC1 protein of S. cerevisiae plays a role in manganese homeostasis.; Remark: the N. crassa mutant frost has a hyperbranching phenotype that can be corrected by adding Ca(2+).; Remark: the fr mutant of N. crassa was sensitive to Mn(2+), and a revertant allele whose product differs by one amino acid was tolerant to Mn(2+). Mn(2+) depletion induced the wild-type strain to hyperbranch, resulting in a morphology similar to that of fr. the fr mutant of N. crassa was also sensitive to calcineurin inhibitors.; Similarity: the predicted A. niger protein shows strong similarity to the frost gene (fr) of N. crassa and to the CDC1 proteins from the yeasts S. cerevisiae and S. pombe.; Title: strong similarity to frost gene fr -Neurospora crassa; See PMID 10669587; uncharacterized protein 934196 4987992 An15g03910 Aspergillus niger uncharacterized protein XP_001396928.3 932043 D 5061 CDS An15g03930 84593180 complement(join(934919..934981,935032..935120,935312..935438,935551..935694,935773..935886)) III 1 NT_166530.1 hypothetical protein 935886 84593180 An15g03930 Aspergillus niger hypothetical protein XP_059606492.1 934919 R 5061 CDS An15g03940 4987995 join(936381..936478,936542..936870,936926..937387,937441..938135) III 1 NT_166530.1 Function: monosaccharide transporter Mst-1 of A. muscaria is involved in the active uptake of monosaccharides.; Induction: monosaccharide transporter Mst-1 of A. muscaria is upregulated in ectomycorrhizas by a monosaccharide-controlled mechanism.; Similarity: the predicted A. niger protein shows strong similarity to the monosaccharide transporter Mst-1 of A. muscaria, which belongs to the sugar transporter family.; Title: strong similarity to monosaccharide transporter AmMst-1 - Amanita muscaria; plasma membrane; See PMID 9487692; uncharacterized protein 938135 4987995 An15g03940 Aspergillus niger uncharacterized protein XP_001396930.1 936381 D 5061 CDS An15g03950 4987996 join(938642..939388,939428..940552) III 1 NT_166530.1 Catalytic activity: lingual triacylglycerol lipase of R. norvegicus catalyses the reaction triacylglycerol + H(2)O = diacylglycerol + a fatty acid anion.; Pathway: lingual triacylglycerol lipase of R. norvegicus catalyses the first step in glycerolipid catabolism.; Title: strong similarity to precursor of lingual triacylglycerol lipase - Rattus norvegicus; See PMID 3839077; uncharacterized protein 940552 4987996 An15g03950 Aspergillus niger uncharacterized protein XP_059606493.1 938642 D 5061 CDS An15g03960 84593181 complement(join(940720..940946,941047..941108,941302..941426)) III 1 NT_166530.1 hypothetical protein 941426 84593181 An15g03960 Aspergillus niger hypothetical protein XP_059606494.1 940720 R 5061 CDS An15g03970 84593182 complement(join(942087..942181,942364..942445,942528..942560,942784..942941,943237..943420)) III 1 NT_166530.1 hypothetical protein 943420 84593182 An15g03970 Aspergillus niger hypothetical protein XP_059606495.1 942087 R 5061 CDS An15g03980 4987999 join(944051..944345,944424..944513,944643..944658,944717..944888,944953..945020,945105..945225,945284..945788,945858..945960,946016..946103) III 1 NT_166530.1 Catalytic activity: oxalate decarboxylase from C. velutipes catalyses the reaction oxalate = formate + CO(2).; Pathway: oxalate decarboxylase from C. velutipes is involved in glyoxylate and dicarboxylate metabolism.; Remark: an oxalate decarboxylase (APOXD) from A. phoenices is covered by patent WO9842827-A2 (AC# AAW79948). APOXD may be used for e. g. degrading oxalic acid,protecting against oxalic toxicity or as a selectable marker in plants.; Remark: oxalic acid is present as nutritional stress in many crop plants like Amaranth and Lathyrus. oxalic acid has also been found to be involved in the attacking mechanism of several phytopathogenic fungi.; Remark: transgenic tobacco and tomato plants expressing oxalate decarboxylase from C. velutipes show remarkable resistance to phytopathogenic fungus Sclerotinia sclerotiorum that utilizes oxalic acid during infestation.; Title: strong similarity to oxalate decarboxylase -Collybia velutipes; See PMID 10702293; uncharacterized protein 946103 4987999 An15g03980 Aspergillus niger uncharacterized protein XP_001396934.3 944051 D 5061 CDS An15g03990 4988000 complement(join(946320..946355,946443..946761,946833..947104,947187..947440,947527..947675,947762..947953,948020..948152,948212..948404)) III 1 NT_166530.1 Function: OMST-oxidoreductase from A. flavus converts O-methylsterigmatocystin (OMST) to aflatoxin B1.; Pathway: OMST-oxidoreductase from A. flavus catalyses the last step of the aflatoxin biosynthetic pathway.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Similarity: the predicted A. niger protein shows strong similarity to OMST-oxidoreductase (ord1) from A. flavus, which belongs to the cytochrome P-450-type monooxygenase gene family CYP64.; Title: strong similarity to O-methylsterigmatocystin oxidoreductase ord1 - Aspergillus flavus; See PMID 9143099; See PMID 7793957; uncharacterized protein 948404 4988000 An15g03990 Aspergillus niger uncharacterized protein XP_001396935.3 946320 R 5061 CDS An15g04000 84593183 complement(join(949564..949794,949890..950100,950493..950607,950707..950766,950868..950966,951078..951129)) III 1 NT_166530.1 hypothetical protein 951129 84593183 An15g04000 Aspergillus niger hypothetical protein XP_059606496.1 949564 R 5061 CDS An15g04010 4988002 complement(join(951467..951723,951757..952537)) III 1 NT_166530.1 Title: strong similarity to hypothetical protein encoded by An14g06160 - Aspergillus niger; uncharacterized protein 952537 4988002 An15g04010 Aspergillus niger uncharacterized protein XP_059606497.1 951467 R 5061 CDS An15g04020 84593184 complement(join(952728..952864,952918..953082,953167..953269)) III 1 NT_166530.1 hypothetical protein 953269 84593184 An15g04020 Aspergillus niger hypothetical protein XP_059606498.1 952728 R 5061 CDS An15g04030 84593185 complement(join(953396..953527,953617..953641,953686..953736,954084..954190)) III 1 NT_166530.1 Title: questionable ORF; uncharacterized protein 954190 84593185 An15g04030 Aspergillus niger uncharacterized protein XP_059606499.1 953396 R 5061 CDS An15g04040 4988005 join(954422..954823,954920..959209) III 1 NT_166530.1 Function: the toxins have activity against Lepidopteran insects and Coleopteran insects, and are active against strains resistant to known insecticides.; Remark: P. luminescens is a member of the Enterobacteriaceae family and is a symbiotic bacterium of nematodes of the genus Heterorhabditis; the nematodes colonise insect larvae, kill them, and their offspring feed on the dead larvae; however, the insecticidal agents are produced by P. luminescens rather than the nematodes.; Remark: the 176 kD insecticidal toxin from P. luminescens is one of five insecticidal toxins encoded by ORFs arranged in an operon-like structure in a 9. 7kb fragment of P. luminescens DNA.; Similarity: the predicted ORF is also very similar to the nematicidal protein 2 produced by Xenorhabdus bovienii, still unpublished.; Title: strong similarity to 176 kD insecticidal toxin from patent WO9942589-A2 - Photorhabdus luminescens; uncharacterized protein 959209 4988005 An15g04040 Aspergillus niger uncharacterized protein XP_059606500.1 954422 D 5061 CDS An15g04050 4988006 join(959870..959977,960030..960446,960498..961160,961210..962271) III 1 NT_166530.1 Phenotype: KHA1 mutants in S. cerevisiae accumulate K+, show net influx without a significant difference in efflux, as well as an increased growth rate, smaller cells,and twice the cell yield per glucose used; mutant cells also produce a greater acidification of the medium coincident with an internal pH alkalinization and show a higher oxygen consumption velocity.; Remark: KHA1 of S. cerevisiae is also known as YJL094c.; Title: strong similarity to K+/H+ exchanger Kha1 -Saccharomyces cerevisiae; plasma membrane; See PMID 8720066; See PMID 9348664; See PMID 9678606; See PMID 9811642; See PMID 10628851; uncharacterized protein 962271 4988006 An15g04050 Aspergillus niger uncharacterized protein XP_001396941.3 959870 D 5061 CDS An15g04060 4988007 complement(962950..964686) III 1 NT_166530.1 Function: S. cerevisiae Flr1 is a transmembrane transporter confering fluconazole resistance.; Induction: S. cerevisiae Flr1 is transcriptionally regulated by the Cap1 and yAP-1 proteins.; Remark: YBR008c is the systematic name for S. cerevisiae Flr1.; Similarity: S. cerevisiae Flr1 belongs to the major facilitator family (TC 2. A. 1).; Title: strong similarity to fluconazole resistance transporter Flr1 - Saccharomyces cerevisiae; plasma membrane; See PMID 9235926; uncharacterized protein 964686 4988007 An15g04060 Aspergillus niger uncharacterized protein XP_001396942.3 962950 R 5061 CDS An15g04070 84593186 complement(join(965005..965158,965248..965381,965460..965585)) III 1 NT_166530.1 hypothetical protein 965585 84593186 An15g04070 Aspergillus niger hypothetical protein XP_059606501.1 965005 R 5061 CDS An15g04080 84593187 join(965621..965708,965792..965935,966030..966051,966111..966432) III 1 NT_166530.1 hypothetical protein 966432 84593187 An15g04080 Aspergillus niger hypothetical protein XP_059606502.1 965621 D 5061 CDS An15g04100 4988011 join(970552..970782,970848..971144,971207..971527,971596..972183) III 1 NT_166530.1 Pathway: the DOX proteins constitute a complete upper naphthalene catabolic pathway.; Remark: DoxF is one of the DOX proteins, converting naphthalene to salicylate and phenanthrene to 1-hydroxy-2-naphthoic acid.; Title: strong similarity to salicylaldehyde dehydrogenase doxF - Pseudomonas sp.; See PMID 8226631; uncharacterized protein 972183 4988011 An15g04100 Aspergillus niger uncharacterized protein XP_001396945.1 970552 D 5061 CDS An15g04110 84593188 join(973129..973231,973359..973730,973794..973900,973984..974150,974462..974555,974697..974892,975074..975090) III 1 NT_166530.1 Remark: the ORF has an unusual exon/intron structure.; Title: weak similarity to hypothetical protein encoded by An08g09080 - Aspergillus niger; uncharacterized protein 975090 84593188 An15g04110 Aspergillus niger uncharacterized protein XP_059606503.1 973129 D 5061 CDS An15g04120 4988013 join(975863..976524,976622..977092,977141..977247,977390..977406) III 1 NT_166530.1 Title: strong similarity to hypothetical protein encoded by An01g01140 - Aspergillus niger; uncharacterized protein 977406 4988013 An15g04120 Aspergillus niger uncharacterized protein XP_059606504.1 975863 D 5061 CDS An15g04130 4988014 complement(join(977979..978372,978444..978823,978883..978980,979046..979133)) III 1 NT_166530.1 Function: pth11 of M. grisea is not required for appressorium morphogenesis but is involved in host surface recognition; it represses differentiation on poorly inductive surfaces; Function: pth11 of M. grisea mediates appressorium differentiation in response to inductive substrate cues.; Localization: pth11 of M. grisea is found at the cell membrane and vacuoles.; Phenotype: pth11 mutants of M. grisea are nonpathogenic due to the defect in appressorium differentiation.; Remark: fungi infect plants by appressorium formation.; Title: similarity to appressorium differentiation protein pth11 - Magnaporthe grisea; See PMID 10521529; uncharacterized protein 979133 4988014 An15g04130 Aspergillus niger uncharacterized protein XP_001396948.3 977979 R 5061 CDS An15g04140 4988015 join(981010..981252,981303..981447,981500..981768,981824..982681,982892..984331,984386..988279,988336..989184) III 1 NT_166530.1 Function: PKS1 from C. heterostrophus encodes a multifunctional polyketide synthase with six catalytic domains: beta-ketoacyl synthase, acyltransferase,dehydratase, enoyl reductase, beta-ketoacyl reductase and acyl carrier protein.; Phenotype: PKS1 in race T of the fungal pathogen C. heterostrophus was inactivated by targeted gene disruption,T-toxin production and high virulence were eliminated,indicating that this PKS is required for fungal virulence.; Remark: race T of the fungal pathogen C. heterostrophus may have acquired PKS1 by horizontal DNA-transfer rather than by vertical inheritance from an ancestral strain.; Title: strong similarity to polyketide synthase PKS1 - Cochliobolus heterostrophus; See PMID 8953776; uncharacterized protein 989184 4988015 An15g04140 Aspergillus niger uncharacterized protein XP_059606505.1 981010 D 5061 CDS An15g04150 4988016 join(<989638..989930,990014..990204,990275..>990670) III 1 NT_166530.1 Function: the introduction of extra copies of Orf11 genes in a S. coelicolor actIII mutant restores the ability to produce actinorhodin.; Remark: the ORF is truncated and contains no stop codon, due to the end of the contig.; Remark: the disruption of the Orf11 gene in S. coelicolor appears to have no significant effect on the production of actinorhodin.; Title: strong similarity to oxidoreductase involved in actinorhodin production encoded by Orf11 - Streptomyces lividans; See PMID 10400594; uncharacterized protein 990670 4988016 An15g04150 Aspergillus niger uncharacterized protein XP_001396950.3 989638 D 5061 CDS An15g04160 4988017 complement(join(<990776..991328,991473..991813)) III 1 NT_166530.1 Remark: it is assumed, that this sequence probably has been incorporated into the A. niger sample and is a putative cloning artefact.; Remark: the predicted ORF is identical to exodeoxyribonuclease I sbc originally found in E. coli.; Title: strong similarity to exodeoxyribonuclease I sbc - Escherichia coli [putative cloning artefact]; uncharacterized protein 991813 4988017 An15g04160 Aspergillus niger uncharacterized protein XP_059606506.1 990776 R 5061 CDS An15g04170 4988018 991829..992389 III 1 NT_166530.1 Remark: the distance to ORF 110WK is only 15 base pairs.; hypothetical protein 992389 4988018 An15g04170 Aspergillus niger hypothetical protein XP_001396952.3 991829 D 5061 CDS An15g04180 4988019 993326..994636 III 1 NT_166530.1 Title: strong similarity to hypothetical cytochrome P450 related protein B13N20.260 - Neurospora crassa; uncharacterized protein 994636 4988019 An15g04180 Aspergillus niger uncharacterized protein XP_001396953.1 993326 D 5061 CDS An15g04190 4988020 complement(join(997610..997841,997903..999086)) III 1 NT_166530.1 Title: similarity to hypothetical protein encoded by An13g03430 - Aspergillus niger; uncharacterized protein 999086 4988020 An15g04190 Aspergillus niger uncharacterized protein XP_001396954.3 997610 R 5061 CDS An15g04200 84593189 complement(join(999505..999666,999732..999932,1000005..1000159,1000190..1000248,1000328..1000797)) III 1 NT_166530.1 Title: similarity to hypothetical protein encoded by An02g01120 - Aspergillus niger; uncharacterized protein 1000797 84593189 An15g04200 Aspergillus niger uncharacterized protein XP_059606507.1 999505 R 5061 CDS An15g04210 4988022 1001640..1002650 III 1 NT_166530.1 Similarity: the predicted ORF shows strong similarity to putative oxidoreductases with various substrate specificities and also strong homology to potassium channels from some species.; Title: strong similarity to hypothetical oxidoreductase SPAC977.14c - Schizosaccharomyces pombe; uncharacterized protein 1002650 4988022 An15g04210 Aspergillus niger uncharacterized protein XP_001396956.1 1001640 D 5061 CDS An15g04220 4988023 complement(join(1002901..1004542,1004699..1005018)) III 1 NT_166530.1 Title: strong similarity to hypothetical protein EAA59582.1 - Aspergillus nidulans; uncharacterized protein 1005018 4988023 An15g04220 Aspergillus niger uncharacterized protein XP_059606508.1 1002901 R 5061 CDS An15g04230 4988024 join(1005209..1005667,1005726..1006253) III 1 NT_166530.1 Catalytic activity: dihydrodipicolinate synthases catalyse L-aspartate 4-semialdehyde + pyruvate <=> dihydrodipicolinate + 2 H(2)O.; Function: dapA of C. glutamicum is involved in the lysine biosynthesis by catalyzing the first step in diaminopimelate and lysine biosynthesis.; Similarity: the ORF shows similarity to several bacterial dihydrodipicolinate synthases.; Title: strong similarity to dihydrodipicolinate synthase dapA - Corynebacterium glutamicum; See PMID 8659901; See PMID 9559056; See PMID 10498736; uncharacterized protein 1006253 4988024 An15g04230 Aspergillus niger uncharacterized protein XP_001396958.1 1005209 D 5061 CDS An15g04240 84593190 join(1006661..1006888,1007006..1007069,1007141..1007164,1007248..1007402) III 1 NT_166530.1 hypothetical protein 1007402 84593190 An15g04240 Aspergillus niger hypothetical protein XP_059606509.1 1006661 D 5061 CDS An15g04250 84593191 join(1007985..1009232,1009294..1009484,1009689..1010013) III 1 NT_166530.1 hypothetical protein 1010013 84593191 An15g04250 Aspergillus niger hypothetical protein XP_059606510.1 1007985 D 5061 CDS An15g04260 4988027 complement(1010471..1011625) III 1 NT_166530.1 Title: similarity to hypothetical protein MRI1 -Arabidopsis thaliana; uncharacterized protein 1011625 4988027 An15g04260 Aspergillus niger uncharacterized protein XP_001396961.1 1010471 R 5061 CDS An15g04270 4988028 join(1012122..1012340,1012390..1013100,1013162..1013518,1013573..1013669,1013736..1013917) III 1 NT_166530.1 Similarity: shows strong similarity to several hexose transporter.; Title: strong similarity to quinate transport protein qutD - Aspergillus nidulans; See PMID 1339361; See PMID 2175387; See PMID 2835177; See PMID 2976880; See PMID 3049934; uncharacterized protein 1013917 4988028 An15g04270 Aspergillus niger uncharacterized protein XP_059606511.1 1012122 D 5061 CDS An15g04280 4988029 join(1015411..1015855,1015918..1016276,1016379..1016441) III 1 NT_166530.1 Function: in S. cerevisiae biosynthesis of phosphatidic acid through the dihydroxyacetone phosphate pathway requires NADPH-dependent reduction of the intermediate 1-acyldihydroxyacetone phosphate by AYR1 before the second step of acylation.; Function: phosphatidic acid is a key intermediate in the formation of glycerophospholipids and triacylglycerols.; Localization: in S. cerevisiae lipid particles and the endoplasmic reticulum harbor 1-acyldihydroxyacetone-phosphate reductase (ADR) activity.; Pathway: dihydroxyacetone phosphate pathway.; Remark: the systematic genename of AYR1 is YIL124w.; Title: strong similarity to 1-acyldihydroxyacetone-phosphate reductase Ayr1 -Saccharomyces cerevisiae; See PMID 10617610; uncharacterized protein 1016441 4988029 An15g04280 Aspergillus niger uncharacterized protein XP_001396963.1 1015411 D 5061 CDS An15g04290 4988030 complement(join(1016581..1017064,1017175..1018196,1018255..1018323)) III 1 NT_166530.1 Catalytic activity: 6-hydroxy-D-nicotine oxidases catalyze the conversion of (D)-6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H2O2.; Pathway: 6-hydroxy-D-nicotine oxidases are involved in the degradation of nicotine.; Similarity: shows similarity to several putative oxidoreductases.; Title: similarity to 6-hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans; uncharacterized protein 1018323 4988030 An15g04290 Aspergillus niger uncharacterized protein XP_059606512.1 1016581 R 5061 CDS An15g04300 4988031 complement(join(1018717..1018861,1018920..1019203,1019264..1019452,1019506..1019964)) III 1 NT_166530.1 Title: strong similarity to hypothetical protein encoded by EAA61985.1 - Aspergillus nidulans; uncharacterized protein 1019964 4988031 An15g04300 Aspergillus niger uncharacterized protein XP_001396965.1 1018717 R 5061 CDS An15g04310 4988032 join(1020533..1020665,1020728..1021174,1021228..1021694) III 1 NT_166530.1 Catalytic activity: alcohol dehydrogenases convert alcohol + NAD(+) to aldehyde or ketone + NADH.; Similarity: shows strong similarity to several putative alcohol dehydrogenases and oxidoreductases.; Title: strong similarity to alcohol dehydrogenase adhT - Bacillus stearothermophilus; uncharacterized protein 1021694 4988032 An15g04310 Aspergillus niger uncharacterized protein XP_001396966.1 1020533 D 5061 CDS An15g04320 4988033 complement(join(1021837..1023950,1024105..1024111)) III 1 NT_166530.1 Similarity: N-terminal third shows similarity to N-terminal third of the A. nidulans facB.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; uncharacterized protein 1024111 4988033 An15g04320 Aspergillus niger uncharacterized protein XP_001396967.3 1021837 R 5061 CDS An15g04330 84593192 complement(1025954..>1026283) III 1 NT_166530.1 Remark: DAL5 of S. cerevsiae encodes a component of the allantoate transport system.; Remark: N-terminally truncated ORF due to contig border.; Remark: the relatively high basal level of expression of S. cerevisiae DAL5 did not increase further upon addition of allantoin pathway intermediates.; Remark: the systematic genename of S. cerevisiae DAL5 is YJR152W.; Title: similarity to allantoate permease Dal5 -Saccharomyces cerevisiae [truncated ORF]; See PMID 3275614; See PMID 3301804; uncharacterized protein 1026283 84593192 An15g04330 Aspergillus niger uncharacterized protein XP_059606513.1 1025954 R 5061 CDS An15g04340 4988035 complement(join(<1026388..1026638,1026695..1026780,1026841..1026981,1027031..1027400,1027455..1027552,1027601..1027662,1027710..1027764,1027809..1027872,1027922..1028033)) III 1 NT_166530.1 Function: Dal5 from S. cerevisiae is a component of the allantoate transport system.; Regulation: DAL5 gene from S. cerevisiae is constitutively expressed but repressed when a nitrogen source was provided.; Remark: synonyms for Dal5 from S. cerevisiae are UreP1, J2230 and YJR152w.; Similarity: Dal5 from S. cerevisiae belongs to the allantoate permease family.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 3294799; See PMID 3301804; uncharacterized protein 1028033 4988035 An15g04340 Aspergillus niger uncharacterized protein XP_001396969.3 1026388 R 5061 CDS An15g04350 4988036 join(1028557..1028788,1028847..1029136,1029206..1029782,1029840..1030101,1030146..1030176) III 1 NT_166530.1 Similarity: the ORF encoded protein shows also strong similarities to other oxidoreductases.; Title: strong similarity to hypothetical oxidoreductase encoded by mll6520 - Mesorhizobium loti; uncharacterized protein 1030176 4988036 An15g04350 Aspergillus niger uncharacterized protein XP_001396970.3 1028557 D 5061 CDS An15g04360 4988037 complement(join(1030238..1030376,1030434..1030995,1031056..1031095)) III 1 NT_166530.1 Catalytic activity: (S)-2-haloacid + H(2)O <=> (R)-2-hydroxyacid + halide.; Remark: Acts on acids of short-chain lengths, C(2) to C(4), with inversion of configuration at C-2.; Title: similarity to haloacid dehalogenase dhlB -Xanthobacter autotrophicus; See PMID 1744048; uncharacterized protein 1031095 4988037 An15g04360 Aspergillus niger uncharacterized protein XP_001396971.1 1030238 R 5061 CDS An15g04370 4988038 join(1031565..1031743,1031857..1031964,1032025..1032970) III 1 NT_166530.1 Catalytic activity: hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl- hydroxyproline analogs.; Remark: Microbacterium esteraromaticum = Aureobacterium esteraromaticum.; Title: similarity to proline dipeptidase from patent JP11318454-A - Microbacterium esteraromaticum; uncharacterized protein 1032970 4988038 An15g04370 Aspergillus niger uncharacterized protein XP_059606514.1 1031565 D 5061 CDS An15g04380 4988039 complement(join(1033255..1033643,1033701..1034048,1034097..1034317,1034369..1034669,1034719..1035100)) III 1 NT_166530.1 Catalytic activity: PhacA catalyzes the ortho-hydroxylation of phenylacetate, the first step of A. nidulans phenylacetate catabolism.; Remark: Aspergillus nidulans utilizes phenylacetate as a carbon source via homogentisate, which is degraded to fumarate and acetoacetate.; Remark: Emericella nidulans = Aspergillus nidulans.; Remark: PhacA is a novel cytochrome P450 monooxygenase.; Title: strong similarity to phenylacetate 2-hydroxylase phacA - Aspergillus nidulans; endoplasmatic reticulum; See PMID 10329644; uncharacterized protein 1035100 4988039 An15g04380 Aspergillus niger uncharacterized protein XP_001396973.1 1033255 R 5061 CDS An15g04390 4988040 join(1035383..1035452,1035507..1035660,1035733..1036127,1036193..1036431) III 1 NT_166530.1 Function: hdhA from E. coli catalyses the oxidation of the 7-alpha-hydroxyl group of bile acids and alcohols both in their free and conjugated forms.; Similarity: there are also strong similarities to other oxidoreductases.; Title: strong similarity to 7-alpha-hydroxysteroid dehydrogenase gene hdhA - Escherichia coli; See PMID 2007545; uncharacterized protein 1036431 4988040 An15g04390 Aspergillus niger uncharacterized protein XP_059606515.1 1035383 D 5061 CDS An15g04400 84593193 complement(join(1037222..1038041,1038145..1038239,1038300..1038341)) III 1 NT_166530.1 Similarity: the ORF encoded protein shows significant domain homology to binuclear Zn(2)-Cys(6) cluster domains of many fungal transcription factors.; Title: similarity to transcription factor Sip4 -Saccharomyces cerevisiae; nucleus; See PMID 9843506; See PMID 11169757; uncharacterized protein 1038341 84593193 An15g04400 Aspergillus niger uncharacterized protein XP_059606516.1 1037222 R 5061 CDS An15g04410 4988042 join(1038703..1038729,1038861..1038955,1039008..1039774,1039811..1039887,1039940..1040824) III 1 NT_166530.1 Function: Ppr1 from S. cerevisiaeis is a positive transcriptional regulator of the Ura1 and Ura3 genes.; Remark: the synonym for Ppr1 from S. cerevisiae is YLR014c.; Remark: the zinc finger and additional 14 amino acids of the carboxyl side of Ppr1 from S. cerevisiae are sufficient for the DNA-binding specificity.; Title: similarity to transcription activator Ppr1 -Saccharomyces cerevisiae; nucleus; See PMID 2118990; See PMID 6096562; uncharacterized protein 1040824 4988042 An15g04410 Aspergillus niger uncharacterized protein XP_059606517.1 1038703 D 5061 CDS An15g04420 4988043 complement(join(1041025..1041084,1041141..1041494,1041550..1042214,1042276..1042450)) III 1 NT_166530.1 Catalytic activity: NADH + acceptor = NAD+ + reduced acceptor.; Cofactor: FAD; contains 2 FAD molecules per subunit.; Complex: the NADH oxidase from T. brockii exists as a homohexamer.; Function: the NADH oxidase from T. brockii reduces a range of alternative electron acceptors.; Function: the role of the NADH oxidase from T. brockii is not clear.; Remark: ORF contains an internal stop codon, due to a putative sequencing error.; Remark: the NADH oxidase from T. brockii is thermostable.; Title: similarity to NADH oxidase -Thermoanaerobacter brockii [putative sequencing error]; putative sequencing error; See PMID 8357835; See PMID 1599437; uncharacterized protein 1042450 4988043 An15g04420 Aspergillus niger uncharacterized protein XP_001396977.3 1041025 R 5061 CDS An15g04430 4988044 complement(1043661..1045463) III 1 NT_166530.1 hypothetical protein 1045463 4988044 An15g04430 Aspergillus niger hypothetical protein XP_001396978.1 1043661 R 5061 CDS An15g04440 4988045 complement(join(1046075..1046460,1046533..1046669,1046722..1046809,1046859..1046911,1046965..1047287)) III 1 NT_166530.1 Remark: the encoded protein of patent WO200100844-A2 is a sugar metabolism and oxidative phosphorylation protein for production or modulation of production of fine chemicals e. g. amino acids, carbohydrates or enzymes.; Title: strong similarity to protein involved in carbon metabolism and energy production from patent WO200100844-A2 - Corynebacterium glutamicum; uncharacterized protein 1047287 4988045 An15g04440 Aspergillus niger uncharacterized protein XP_059606518.1 1046075 R 5061 CDS An15g04450 84593194 complement(join(1047474..1047589,1047674..1047890)) III 1 NT_166530.1 hypothetical protein 1047890 84593194 An15g04450 Aspergillus niger hypothetical protein XP_059606519.1 1047474 R 5061 CDS An15g04460 84593195 complement(join(1048810..1048950,1048996..1049190,1049245..1049283)) III 1 NT_166530.1 hypothetical protein 1049283 84593195 An15g04460 Aspergillus niger hypothetical protein XP_059606520.1 1048810 R 5061 CDS An15g04470 4988048 join(1049778..1050783,1050832..1052273) III 1 NT_166530.1 Remark: the matching coding sequence was isolated by carrying out RT-PCR on all of the mRNA obtained from A. thaliana.; Remark: the patent EP1033405-A2 does not provide further information about the function of the protein.; Title: similarity to protein from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 1052273 4988048 An15g04470 Aspergillus niger uncharacterized protein XP_001396982.1 1049778 D 5061 CDS An15g04480 4988049 join(1052652..1053098,1053183..1053317) III 1 NT_166530.1 Title: similarity to hypothetical protein B13C5.110 - Neurospora crassa; uncharacterized protein 1053317 4988049 An15g04480 Aspergillus niger uncharacterized protein XP_001396983.1 1052652 D 5061 CDS An15g04490 4988050 complement(join(1053496..1053926,1053979..1054541,1054588..1054847,1054883..1054974,1055021..1056718,1056769..1057251,1057328..1057373,1057470..1057706,1057799..1057801)) III 1 NT_166530.1 Catalytic activity: ATP + H(2)O <=> ADP + phosphate.; Function: myoA involved in hyphal morphogenesis,vesicle migration, septal wall formation, and cell polarity.; Localization: a GFP-myoA fusion protein in Aspergillus nidulans is enriched in growing hyphal tips, at sites of septum formation and in patches at the cell cortex.; Title: strong similarity to myosin I myoA -Aspergillus nidulans; cytoskeleton; See PMID 7860631; See PMID 9756952; See PMID 10658211; uncharacterized protein 1057801 4988050 An15g04490 Aspergillus niger uncharacterized protein XP_059606521.1 1053496 R 5061 CDS An15g04500 84593196 complement(join(1058659..1058858,1059097..1059323,1059398..1059684)) III 1 NT_166530.1 hypothetical protein 1059684 84593196 An15g04500 Aspergillus niger hypothetical protein XP_059606522.1 1058659 R 5061 CDS An15g04510 84593197 complement(join(1060054..1060848,1060910..1060969)) III 1 NT_166530.1 Remark: the patent does not provide further information about the function of the protein.; Remark: the sequence of the patent EP1033405-A2 from A. thaliana was obtained by carrying out RT-PCR on all mRNAs.; Title: similarity to protein fragment from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 1060969 84593197 An15g04510 Aspergillus niger uncharacterized protein XP_059606523.1 1060054 R 5061 CDS An15g04520 4988053 join(1061771..1062082,1062153..1062595,1062650..1064759,1064812..1065372) III 1 NT_166530.1 Complex: Cdc5 from S. cerevisiae is probably recruitet to origin complexes by Dbf4.; Function: Cdc5 from S. cerevisiae is a positive regulator of cyclin-specific anaphase-promoting complex (APC) activity in late mitosis.; Function: Cdc5 from S. cerevisiae is essential for the onset of Clb2p proteolysis but not for Clb5p proteolysis.; Function: Cdc5 from S. cerevisiae is involved in regulation of DNA replication.; Function: Cdc5 from S. cerevisiae is required for exit of mitosis.; Function: Cdc5 from S. cerevisiae phosphorylates Dbf4p.; Function: the degradation of Cdc5p from S. cerevisiae in G1 might provide a feedback mechanism by which the APC destroys its activator at the onset of the next cell cycle.; Induction: CDC5 transcript from S. cerevisiae accumulation peaks at the G2/M boundary.; Phenotype: cdc5-1 mutants are defective in destruction of cyclins and show a reduction in the cyclin-ubiquitin ligase activity of the anaphase-promoting complex.; Remark: synonyms for Cdc5 from S. cerevisiae are Pkx2, Msd2 and YMR001c.; Repression: Cdc5 from S. cerevisiae degraded in G1 by an anaphase-promoting complex and Hct1 dependent mechanism.; Title: similarity to polo-like protein kinase Cdc5 -Saccharomyces cerevisiae; deleted EC_number 2.7.1.37; nucleus; See PMID 8321244; See PMID 9819423; See PMID 10594031; See PMID 10678171; See PMID 11157974; uncharacterized protein 1065372 4988053 An15g04520 Aspergillus niger uncharacterized protein XP_001396987.1 1061771 D 5061 CDS An15g04530 84593198 join(1066467..1066527,1066582..1067007,1067094..1067549,1067709..1067829,1067920..1068082) III 1 NT_166530.1 Function: rhaB is a polysaccharidase.; Similarity: shows only partial similarity to rhaB.; Title: weak similarity to rhamnosidase B precursor rhaB - Aspergillus aculeatus; See PMID 11319105; uncharacterized protein 1068082 84593198 An15g04530 Aspergillus niger uncharacterized protein XP_059606524.1 1066467 D 5061 CDS An15g04540 84593199 complement(1068597..1069400) III 1 NT_166530.1 Function: contains a BTB/POZ domain that mediates homomeric dimerisation and in some instances heteromeric dimerisation in proteins mainly involved in transcriptional regulation.; Similarity: shows only partial similarity to several hypothetical proteins.; Title: weak similarity to hypothetical protein B21O8.120 - Neurospora crassa; uncharacterized protein 1069400 84593199 An15g04540 Aspergillus niger uncharacterized protein XP_059606525.1 1068597 R 5061 CDS An15g04550 4988056 complement(join(1070540..1070939,1070995..1071365)) III 1 NT_166530.1 Catalytic activity: endohydrolysis of 1,4-beta-D-xylosidic linkages in xylans.; Pathway: xylan degradation.; Remark: patented enzyme is used for bleaching at increased temperatures.; Title: strong similarity to xylanase A xynA from patent WO200068396-A2 - Aspergillus niger; extracellular/secretion proteins; uncharacterized protein 1071365 4988056 An15g04550 Aspergillus niger uncharacterized protein XP_001396990.1 1070540 R 5061 CDS An15g04560 84593200 join(1071861..1071961,1072883..1072966,1073052..1073303,1073419..1073489,1073621..1074057) III 1 NT_166530.1 hypothetical protein 1074057 84593200 An15g04560 Aspergillus niger hypothetical protein XP_059606526.1 1071861 D 5061 CDS An15g04570 4988058 join(1074611..1074941,1075012..1075255,1075320..1075767) III 1 NT_166530.1 Function: enzyme of T. reesei is involved in degradation of polysaccharids.; Title: strong similarity to endoglucanase IV -Trichoderma reesei; extracellular/secretion proteins; See PMID 9370370; uncharacterized protein 1075767 4988058 An15g04570 Aspergillus niger uncharacterized protein XP_001396992.1 1074611 D 5061 CDS An15g04580 4988059 complement(join(1076366..1076698,1076763..1077637,1077702..1077967,1078025..1078140)) III 1 NT_166530.1 Function: it is assumed, that the A. chrysogenum protein might be a membrane transporter used in A. chrysogenum to improve the fermentation ability.; Remark: patent W14439 against protein.; Similarity: shows strong similarity to several major facilitator transport proteins of S. pombe, C. albicans,P. olsonii.; Title: strong similarity to protein involved in cephalosporin C biosynthesis from patent JP09009966-A -Acremonium chrysogenum; uncharacterized protein 1078140 4988059 An15g04580 Aspergillus niger uncharacterized protein XP_001396993.1 1076366 R 5061 CDS An15g04590 4988060 join(1078849..1080563,1080617..1080731,1080777..1080812) III 1 NT_166530.1 Function: might be a transcriptional regulator.; Similarity: shows similarity to several proteins containing Zn(II)2Cys6 clusters.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; uncharacterized protein 1080812 4988060 An15g04590 Aspergillus niger uncharacterized protein XP_059606527.1 1078849 D 5061 CDS An15g04600 4988061 join(1082809..1083061,1083113..1083258,1083305..1085335) III 1 NT_166530.1 Function: P. chrysogenum uses sulfate as a source of sulfur for the biosynthesis of penicillin.; Function: sutB of P. chrysogenum is a sulfate transporter.; Remark: protein of P. chrysogenum is patented and there exist two similiar genes sutA and sutB.; Title: strong similarity to sulfate permease SutB -Penicillium chrysogenum; plasma membrane; See PMID 10572125; See PMID 11010912; uncharacterized protein 1085335 4988061 An15g04600 Aspergillus niger uncharacterized protein XP_001396995.1 1082809 D 5061 CDS An15g04610 4988062 join(<1085793..1085909,1085981..1086946) III 1 NT_166530.1 Catalytic activity: the enzyme of G. mastotermitis catalyses the second step in the xylose utilising pathway converting xylose to xylulosephosphate.; Pathway: Xylulose-phosphate is further degraded by the transaldolase and transketolase reactions of the pentose phosphate pathway.; Title: strong similarity to xylitol dehydrogenase xdh - Galactocandida mastotermitis [truncated ORF]; See PMID 10661867; uncharacterized protein 1086946 4988062 An15g04610 Aspergillus niger uncharacterized protein XP_001396996.3 1085793 D 5061 CDS An15g04620 4988063 complement(join(1086996..1087501,1087555..1087869,1087925..1088130,1088186..1088211)) III 1 NT_166530.1 Catalytic activity: DTDP-Glucose = DTDP-4-Dehydro-6-Deoxy-D- Glucose + H(2)O.; Function: involved in anabolism pathway to biosynthesis of the O antigen of lipopolysaccharide.; Similarity: shows similarity to glucose-4,6-dehydratase enzymes of different species.; Title: similarity to dTDP-glucose-4,6-dehydratase rmlB - Streptococcus mutans; See PMID 9023194; uncharacterized protein 1088211 4988063 An15g04620 Aspergillus niger uncharacterized protein XP_001396997.1 1086996 R 5061 CDS An15g04630 4988064 join(1089564..1089875,1089931..1090328,1090481..1091369) III 1 NT_166530.1 Function: contains domain typical for sugar transporter.; Remark: similarity to patented sequence from Pompejus M., Kroeger B., Schroeder H., Zelder O., Haberhauer G.; 'corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport'; Patent number WO0100805-A/513, 04-JAN-2001. BASF AKTIENGESELLSCHAFT (DE).; Similarity: shows higher similarity to putative membrane transporter form S. pombe.; Title: similarity to sequence 513 from patent WO0100805 - Corynebacterium glutamicum; plasma membrane; uncharacterized protein 1091369 4988064 An15g04630 Aspergillus niger uncharacterized protein XP_059602532.1 1089564 D 5061 CDS An15g04640 4988065 complement(join(1091494..1091834,1091918..1092347)) III 1 NT_166530.1 Function: protein of in involved in antibiotic resistance.; Similarity: shows only partial similarity to proteins containing domain typical for acetyltransferase (GNAT) family.; Title: weak similarity to puromycin N-acetyltransferase pac - Streptomyces anulatus; uncharacterized protein 1092347 4988065 An15g04640 Aspergillus niger uncharacterized protein XP_001396999.1 1091494 R 5061 CDS An15g04650 4988066 complement(1092779..1093807) III 1 NT_166530.1 Title: strong similarity to hypothetical protein EAA64269.1 - Aspergillus nidulans; uncharacterized protein 1093807 4988066 An15g04650 Aspergillus niger uncharacterized protein XP_001397000.1 1092779 R 5061 CDS An15g04660 4988067 join(1095208..1095425,1095506..1095789,1095860..1096443) III 1 NT_166530.1 Remark: blast hit against patented sequence from Pompejus M., Kroeger B., Schroeder H., Zelder O., Haberhauer G.; 'corynebacterium glutamicum genes encoding proteins involved in carbon metabolism and energy production' Patent number WO0100844-A/143, 04-JAN-2001. BASF AKTIENGESELLSCHAFT (DE).; Title: similarity to sequence 143 from patent WO0100844 - Corynebacterium glutamicum; uncharacterized protein 1096443 4988067 An15g04660 Aspergillus niger uncharacterized protein XP_059602533.1 1095208 D 5061 CDS An15g04670 4988068 complement(join(1096545..1096872,1096936..1097639)) III 1 NT_166530.1 Similarity: shows only partial similarity to the patented proteinsequence.; Title: similarity to protein #1230 from patent WO200177335-A - Listeria monocytogenes; uncharacterized protein 1097639 4988068 An15g04670 Aspergillus niger uncharacterized protein XP_001397002.1 1096545 R 5061 CDS An15g04680 4988069 complement(join(1098013..1099787,1099834..1100198,1100244..1100650)) III 1 NT_166530.1 Function: the polynucleotides described in AAQ97525-27 encode the human analogues of the prokaryotic mutL4 DNA repair gene.; Similarity: shows only partial similarity to mutL homologues.; Title: similarity to DNA repair protein hMLH2 from patent WO9520678-A1 - Homo sapiens; nucleus; uncharacterized protein 1100650 4988069 An15g04680 Aspergillus niger uncharacterized protein XP_001397003.1 1098013 R 5061 CDS An15g04690 4988070 join(1100962..1101296,1101347..1101518,1101572..1101871,1101929..1102007,1102055..1102219,1102313..1102446) III 1 NT_166530.1 Similarity: shows only partial similarity to patented protein.; Title: similarity to protein fragment SEQ ID NO:49734 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 1102446 4988070 An15g04690 Aspergillus niger uncharacterized protein XP_059602534.1 1100962 D 5061 CDS An15g04700 4988071 complement(join(1102695..1105433,1105867..1106106,1106361..1106510,1106637..1106702)) III 1 NT_166530.1 Title: similarity to hypothetical hydroxymethyltransferase AAL18983.1 - Salmonella typhimurium; uncharacterized protein 1106702 4988071 An15g04700 Aspergillus niger uncharacterized protein XP_001397005.3 1102695 R 5061 CDS An15g04710 84593201 join(1107295..1107405,1107513..1107551,1107599..1107715) III 1 NT_166530.1 hypothetical protein 1107715 84593201 An15g04710 Aspergillus niger hypothetical protein XP_059602535.1 1107295 D 5061 CDS An15g04720 4988073 join(1109060..1109338,1109393..1109656,1109793..1109914,1110189..1110811,1110927..1111046,1111120..1111296,1111401..1111489) III 1 NT_166530.1 Similarity: blast hits mainly result from repetitive sequences.; Title: weak similarity to transactivator EBNA-2 -Herpesvirus papio HVP; uncharacterized protein 1111489 4988073 An15g04720 Aspergillus niger uncharacterized protein XP_059602536.1 1109060 D 5061 CDS An15g04740 4988075 join(1112164..1113127,1113219..1113609,1113667..1113955,1114017..1114336,1114415..1114757) III 1 NT_166530.1 Similarity: Similarity is restricted to zinc cluster in N-terminal part of protein.; Title: weak similarity to transcription activator of lysine pathway Lys14 - Saccharomyces cerevisiae; uncharacterized protein 1114757 4988075 An15g04740 Aspergillus niger uncharacterized protein XP_059602537.1 1112164 D 5061 CDS An15g04750 10097992 complement(join(1114926..1114966,1115016..1116009,1116347..1116913)) III 1 NT_166530.1 Similarity: partial similarity results from repetitive sequences.; Title: weak similarity to EH domain binding protein h-NUMB-R from patent WO9846744-A1 - Homo sapiens; uncharacterized protein 1116913 10097992 An15g04750 Aspergillus niger uncharacterized protein XP_003188925.2 1114926 R 5061 CDS An15g04760 4988077 complement(join(1118061..1118228,1118413..1119789,1119848..1119931)) III 1 NT_166530.1 Catalytic activity: glucan endo-1,3-alpha-glucosidase catalyzes the conversion of endohydrolysis of 1,3-alpha-D-glucosidic linkages in isolichenin, pseudonigeran and nigeran.; Function: P. purporogenum mutA is a mutanase (glucan endo-1,3-alpha-glucosidase) involved in polysaccharid catabolism.; Title: similarity to mutanase mutA - Penicillium purporogenum; See PMID 10636904; uncharacterized protein 1119931 4988077 An15g04760 Aspergillus niger uncharacterized protein XP_001397010.3 1118061 R 5061 CDS An15g04770 4988078 complement(join(1121550..1121655,1121716..1122254,1122315..1122950,1123004..1123031,1123087..1123307)) III 1 NT_166530.1 Catalytic activity: GAD catalyzes the conversion of glutamic acid to gamma-aminobutyric acid and the plant GAD binds calmodulin which has not been decribed so far.; Function: It might be possible that intracellular Ca2+ signals via calmodulin are involved in the regulation of gamma-aminobutyric acid synthesis in plants.; Similarity: shows a very strong similarity to undescribed GAD from A. oryzae.; Title: strong similarity to calmodulin-binding glutamate decarboxylase GAD - Petunia hybrida; uncharacterized protein 1123307 4988078 An15g04770 Aspergillus niger uncharacterized protein XP_001397011.1 1121550 R 5061 CDS An15g04780 4988079 join(1124028..1124205,1124254..1125113) III 1 NT_166530.1 Function: this family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.; Similarity: belongs to the aldo/keto reductase family.; Title: strong similarity to protein fragment SEQ ID NO:37791 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 1125113 4988079 An15g04780 Aspergillus niger uncharacterized protein XP_001397012.1 1124028 D 5061 CDS An15g04790 10097993 complement(join(1125238..1127464,1127711..1127797,1127861..1127958)) III 1 NT_166530.1 Function: might be involved in transcriptional regulation.; Similarity: shows partial similarity to protein containing fungal Zn(2)-Cys(6) binuclear cluster.; Title: weak similarity to LEU3 from patent WO8806593-A - Saccharomyces cerevisiae; uncharacterized protein 1127958 10097993 An15g04790 Aspergillus niger uncharacterized protein XP_059602538.1 1125238 R 5061 CDS An15g04800 4988081 join(1130637..1130814,1130871..1133152) III 1 NT_166530.1 Catalytic activity: B2Tom hydrolysis of beta-1,2-glucose residue from tetrasaccharide moeity of alpha-tomatine.; Function: B2Tom is involved in the detoxification of alpha-tomatine found in Lycopersicon spp.; Similarity: shows strong similarity to corresponding enzymes of G. graminis, B. fuckeliana etc and several patented proteins.; Title: strong similarity to beta-1,2-D-glucosidase B2Tom - Septoria lycopersici; extracellular/secretion proteins; uncharacterized protein 1133152 4988081 An15g04800 Aspergillus niger uncharacterized protein XP_001397014.1 1130637 D 5061 CDS An15g04810 4988082 complement(1136669..1138204) III 1 NT_166530.1 Catalytic activity: alpha-1,3-mannosyltransferases are responsible for adding the terminal mannose residues of O-linked oligosaccharides.; Title: similarity to alpha-1,3-mannosyltransferase Mnt2 - Saccharomyces cerevisiae; See PMID 10521541; uncharacterized protein 1138204 4988082 An15g04810 Aspergillus niger uncharacterized protein XP_001397015.1 1136669 R 5061 CDS An15g04820 4988083 join(1139970..1140332,1140396..1140431,1140465..1141905,1141987..1142049,1142117..1142208) III 1 NT_166530.1 Function: vbs of A. parasiticus catalyzes the step from versiconal hemiacetal to versicolorinB.; Pathway: vbs of A. parasiticus catalyzes a step in the aflatoxin biosynthesis.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Title: strong similarity to versicolorin B synthase vbs - Aspergillus parasiticus; See PMID 10855719; uncharacterized protein 1142208 4988083 An15g04820 Aspergillus niger uncharacterized protein XP_059602539.1 1139970 D 5061 CDS An15g04830 4988084 join(1142950..1143430,1143512..1145260,1145510..1145631) III 1 NT_166530.1 Function: in N. crassa, the fusion of hyphae of opposite mating type during vegetative growth results in growth inhibition and cell death, a process that is mediated by the tol locus.; Regulation: tol transcription is repressed to allow the coexistence of opposite mating-type nuclei during the sexual reproductive phase.; Remark: mutations in tol are recessive and suppress mating-type-associated heterokaryon incompatibility.; Title: similarity to vegetative incompatibility protein tol - Neurospora crassa; See PMID 9449795; See PMID 9927450; uncharacterized protein 1145631 4988084 An15g04830 Aspergillus niger uncharacterized protein XP_001397017.3 1142950 D 5061 CDS An15g04840 84593202 complement(join(1145710..1146021,1146105..1146234,1146412..1146591,1146832..1146903,1146996..1147033)) III 1 NT_166530.1 hypothetical protein 1147033 84593202 An15g04840 Aspergillus niger hypothetical protein XP_059602540.1 1145710 R 5061 CDS An15g04850 4988086 join(1147237..1147375,1147431..1149443,1149493..1149551,1149591..1149639,1149745..1149845,1149896..1150169,1150221..1150768) III 1 NT_166530.1 Remark: the Pho85P gene of S. cerevisiae is also called YPL110c or LPH16, but is not identical to Pho85.; Similarity: the predicted ORF is 115 amino acids shorter at the N-terminus than Pho85P of S. cerevisiae.; Title: strong similarity to hypothetical cyclin-dependent protein kinase Pho85 - Saccharomyces cerevisiae; uncharacterized protein 1150768 4988086 An15g04850 Aspergillus niger uncharacterized protein XP_059602541.1 1147237 D 5061 CDS An15g04860 4988087 join(1151543..1151687,1151764..1152388,1152449..1153514) III 1 NT_166530.1 Catalytic activity: UGT51C1 of C. albicans conbverts UDP-glucose + a sterol <=> UDP + an O-glucosylsterol.; Function: UDP-glucose:sterol glucosyltransferases synthesize sterol glucosides, typical membrane-bound lipids of many eukaryotes.; Similarity: the ORF shares the strongest homology with the hypothetical protein CHIP6 of G. cingulata.; Title: strong similarity to UDP-glucose:sterol glucosyltransferase UGT51C1 - Candida albicans; uncharacterized protein 1153514 4988087 An15g04860 Aspergillus niger uncharacterized protein XP_001397020.3 1151543 D 5061 CDS An15g04870 84593203 join(1153636..1154340,1154393..1154531,1154587..1154810) III 1 NT_166530.1 Title: similarity to hypothetical protein expressed during hard surface attachment CHIP6 - Glomerella cingulata; uncharacterized protein 1154810 84593203 An15g04870 Aspergillus niger uncharacterized protein XP_059602542.1 1153636 D 5061 CDS An15g04880 4988089 1155386..1156906 III 1 NT_166530.1 Function: annexins are a family of proteins that bind to acidic phospholipids in a calcium-dependent manner.; Function: annexins have been claimed to be involved in cytoskeletal interactions, phospholipase inhibition,intracellular signalling, anticoagulation, membrane fusion and exocytosis.; Remark: anx7 of H. sapiens is also called ANXA7 or synexin.; Similarity: the ORF show strong similarity to different annexin forms from several species.; Title: strong similarity to annexin 7 anx7 - Homo sapiens; uncharacterized protein 1156906 4988089 An15g04880 Aspergillus niger uncharacterized protein XP_001397022.1 1155386 D 5061 CDS An15g04900 4988091 complement(1159376..1160614) III 1 NT_166530.1 Function: endoglucanases hydrolyse internal 1,4-beta-D-glucosidic linkages in cellulose.; Similarity: the ORF shows similarity with some exoglucanases (EC 3. 2. 1. 91) from different species.; Title: strong similarity to endoglucanase IV egl4 -Trichoderma reesei; uncharacterized protein 1160614 4988091 An15g04900 Aspergillus niger uncharacterized protein XP_059602543.1 1159376 R 5061 CDS An15g04920 4988093 complement(join(1162540..1162767,1162804..1162865,1163041..1163366,1163528..1163580)) III 1 NT_166530.1 Title: similarity to hypothetical protein encoded by An04g06270 - Aspergillus niger; uncharacterized protein 1163580 4988093 An15g04920 Aspergillus niger uncharacterized protein XP_059602544.1 1162540 R 5061 CDS An15g04930 4988094 complement(join(1165056..1166761,1166853..1166888,1167005..1167176)) III 1 NT_166530.1 Function: in N. crassa, the fusion of hyphae of opposite mating type during vegetative growth results in growth inhibition and cell death, a process that is mediated by the tol locus.; Regulation: tol transcription is repressed to allow the coexistence of opposite mating-type nuclei during the sexual reproductive phase.; Remark: mutations in tol are recessive and suppress mating-type-associated heterokaryon incompatibility.; Similarity: the predicted ORF 196 amino acids shorter at the N-terminus and 180 amino acids at the C-terminal end than tol of N. crassa.; Title: strong similarity to vegetative incompatibility protein tol - Neurospora crassa; See PMID 9927450; See PMID 9449795; uncharacterized protein 1167176 4988094 An15g04930 Aspergillus niger uncharacterized protein XP_059602545.1 1165056 R 5061 CDS An15g04940 4988095 1168120..1169277 III 1 NT_166530.1 Function: A. parasiticus norA has norsolorinic acid reductase (NOR) activity.; Function: norA of A. parasiticus is genomically localized within the aflatoxin biosynthetic cluster and has been implicated in aflatoxin biosynthesis.; Induction: A. parasiticus norA mRNA and protein is present only when the fungus is grown in medium conductive to aflatoxin biosynthesis.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Similarity: the ORF shows also strong similarity to several aryl-alcohol dehyrogenases from different species.; Title: strong similarity to norsolorinic acid reductase norA - Aspergillus parasiticus; uncharacterized protein 1169277 4988095 An15g04940 Aspergillus niger uncharacterized protein XP_001397026.1 1168120 D 5061 CDS An15g04950 84593204 complement(join(1169527..1170273,1170335..1170472)) III 1 NT_166530.1 Title: weak similarity to hypothetical protein B11H24.070 - Neurospora crassa; uncharacterized protein 1170472 84593204 An15g04950 Aspergillus niger uncharacterized protein XP_059602546.1 1169527 R 5061 CDS An15g04960 4988097 join(1171408..1171500,1171560..1171657,1171730..1171940) III 1 NT_166530.1 Title: weak similarity to hypothetical protein CAF32133.1 - Aspergillus fumigatus; uncharacterized protein 1171940 4988097 An15g04960 Aspergillus niger uncharacterized protein XP_059602547.1 1171408 D 5061 CDS An15g04970 84593205 complement(join(1172418..1172741,1172927..1172956,1173287..1173340)) III 1 NT_166530.1 Remark: the ORF has an intron-exon structure, which is not typical for A. niger proteins and is only 135 amino acids long.; Title: questionable ORF; uncharacterized protein 1173340 84593205 An15g04970 Aspergillus niger uncharacterized protein XP_059602548.1 1172418 R 5061 CDS An15g04980 84593206 join(1174841..1175297,1175367..1175872) III 1 NT_166530.1 Title: strong similarity to hypothetical protein encoded by An18g00860 - Aspergillus niger; uncharacterized protein 1175872 84593206 An15g04980 Aspergillus niger uncharacterized protein XP_059602549.1 1174841 D 5061 CDS An15g04990 84593207 complement(join(1176072..1176167,1176307..1176657)) III 1 NT_166530.1 Remark: the EST an_2920 of A. niger has database entry code EMBLEST:BE759970.; Remark: the sequence of EST an_2920 of A. niger contains several undefinied bases (n).; Title: similarity to EST an_2920 - Aspergillus niger; uncharacterized protein 1176657 84593207 An15g04990 Aspergillus niger uncharacterized protein XP_059602550.1 1176072 R 5061 CDS An15g05000 84593208 join(1177911..1177990,1178230..1178546,1178673..1179001) III 1 NT_166530.1 Remark: the intron-exon structure of the predicted ORF is not common to A. niger proteins.; hypothetical protein 1179001 84593208 An15g05000 Aspergillus niger hypothetical protein XP_059602551.1 1177911 D 5061 CDS An15g05010 4988102 complement(join(1179972..1180314,1180372..1180512,1180568..1180674)) III 1 NT_166530.1 hypothetical protein 1180674 4988102 An15g05010 Aspergillus niger hypothetical protein XP_001397033.3 1179972 R 5061 CDS An15g05020 4988103 join(1181098..1181321,1181381..1182119) III 1 NT_166530.1 hypothetical protein 1182119 4988103 An15g05020 Aspergillus niger hypothetical protein XP_001397034.1 1181098 D 5061 CDS An15g05030 4988104 1183201..1184334 III 1 NT_166530.1 Function: EstA from S. chrysomallus specifically hydrolyzes short-chain p-nitrophenyl esters.; Remark: formation of EstA from S. chrysomallus starts at the end of growth phase, and its activity level remains constant throughout stationary phase.; Title: strong similarity to esterase A gene EstA -Streptomyces chrysomallus; See PMID 9829953; See PMID 1474897; uncharacterized protein 1184334 4988104 An15g05030 Aspergillus niger uncharacterized protein XP_001397035.1 1183201 D 5061 CDS An15g05050 4988106 join(1185530..1186526,1186589..1187124,1187289..1188213,1188246..1188493) III 1 NT_166530.1 Title: similarity to polypeptide SEQ ID NO:1833 from patent WO200171042-A2 - Drosophila melanogaster; uncharacterized protein 1188493 4988106 An15g05050 Aspergillus niger uncharacterized protein XP_059602552.1 1185530 D 5061 CDS An15g05060 4988107 complement(1188787..1190451) III 1 NT_166530.1 Function: CFP from C. kikuchii is required for wild type cercosporin production, resistance and virulence on soybean.; Remark: cercosporin is a photoactivated perylenequinone toxin that belongs to a family of photosensitizers which absorb light energy and produce extremely cytotoxic, reactive oxygen species.; Similarity: to multidrug resistance transporter proteins of the major facilitator superfamily.; Title: strong similarity to protein involved in cercosporin production CFP - Cercospora kikuchii; See PMID 10517030; uncharacterized protein 1190451 4988107 An15g05060 Aspergillus niger uncharacterized protein XP_001397037.1 1188787 R 5061 CDS An15g05070 4988108 complement(join(1191151..1191169,1191285..1191958,1192022..1193050)) III 1 NT_166530.1 Function: cytochrome P450s are involved in the oxidative degradation of various compounds.; Phenotype: when Cyp3a-13 cDNA from M. musculus was expressed in CR119 cells which had been established as a cell line stably expressing NADPH-cytochrome P-450 reductase cDNA of guinea pigs, aflatoxin B1-dependent cytotoxicity was observed.; Title: similarity to cytochrome P-450 protein Cyp3a-13 - Mus musculus; See PMID 7803471; uncharacterized protein 1193050 4988108 An15g05070 Aspergillus niger uncharacterized protein XP_001397038.3 1191151 R 5061 CDS An15g05080 4988109 complement(join(1193783..1194806,1194865..1195338,1195398..1195546,1195612..1195893,1195968..1196033)) III 1 NT_166530.1 Title: weak similarity to hypothetical protein CAD21084.1 - Neurospora crassa; uncharacterized protein 1196033 4988109 An15g05080 Aspergillus niger uncharacterized protein XP_001397039.1 1193783 R 5061 CDS An15g05090 4988110 join(1197635..1197686,1197742..1198588,1198654..1205174,1205225..1205229) III 1 NT_166530.1 Function: G. fujikuroi FUM5 is a polyketide synthase required for fumonisin-toxin biosynthesis.; Remark: polyketides are synthesized by an evolutionarily related but architecturally diverse family of multifunctional enzymes called polyketide synthases.; Title: strong similarity to polyketide synthase FUM5 - Gibberella moniliformis; See PMID 10413619; uncharacterized protein 1205229 4988110 An15g05090 Aspergillus niger uncharacterized protein XP_001397040.3 1197635 D 5061 CDS An15g05100 4988111 complement(join(1205312..1206613,1206680..1206778)) III 1 NT_166530.1 Induction: expression of S. cerevisiae UPC2 is induced both in anaerobic and cold-shocked cells.; Phenotype: upc2 null mutant of S. cerevisiae does not show the calcium ion sensitivity and sterol uptake seen in upc2-1 mutants.; Phenotype: upc2-1 mutants of S. cerevisiae show a pleiotrophic phenotype including aerobic accumulation of sterols, total lipid storage, sensitivity to metabolic inhibitors, response to altered sterol structures, and cation requirements.; Remark: synonyms for Upc2 from S. cerevisiae are Mox4 and YDR213w.; Similarity: Upc2 from S. cerevisiae belongs to a fungal regulatory familiy containing the Zn(II)2Cys6 binuclear cluster DNA binding domain.; Title: similarity to transcription activator Upc2 -Saccharomyces cerevisiae; nucleus; See PMID 9696767; See PMID 10073572; See PMID 11292809; uncharacterized protein 1206778 4988111 An15g05100 Aspergillus niger uncharacterized protein XP_001397041.1 1205312 R 5061 CDS An15g05110 4988112 complement(join(1207172..1207593,1207661..1208246,1208279..1208391,1208461..1208563,1208634..1208957)) III 1 NT_166530.1 Function: gibberlin synthesis in G. fujikuroi involves at least four cytochrome P450 monooxygenase-catalyzed steps and at least three P450 monooxygenases are involved one of them beeing P450I.; Title: strong similarity to cytochrome P450 monooxygenase P450I - Gibberella fujikuroi; See PMID 9501474; See PMID 9917370; See PMID 10531641; uncharacterized protein 1208957 4988112 An15g05110 Aspergillus niger uncharacterized protein XP_059602553.1 1207172 R 5061 CDS An15g05120 4988113 complement(join(1210730..1210892,1210954..1211071,1211153..1211434,1211675..1211741)) III 1 NT_166530.1 Function: Ypc1 from S. cerevisiae also has reverse activity, catalyzing synthesis of phytoceramide from palmitic acid and phytosphingosine.; Function: Ypc1 from S. cerevisiae encodes a alkaline ceramidase with reverse (CoA-independent) activity.; Function: Ypc1 from S. cerevisiae encodes an alkaline ceramidase activity responsible for the breakdown of dihydroceramide and phytoceramide but not unsaturated ceramide.; Remark: Ceramide is a core intermediate of sphingolipids, an important modulator of many cellular events including apoptosis, cell cycle arrest, senescence,differentiation, and stress responses.; Remark: the synonym for Ypc1 from S. cerevisiae is YBR183W; Title: similarity to alkaline ceramidase Ypc1 -Saccharomyces cerevisiae; See PMID 10702247; See PMID 10900202; uncharacterized protein 1211741 4988113 An15g05120 Aspergillus niger uncharacterized protein XP_059602554.1 1210730 R 5061 CDS An15g05130 4988114 complement(join(1212792..1213163,1213217..1213329,1213405..1214212,1214266..1214423,1214479..1214785)) III 1 NT_166530.1 Catalytic activity: phenol sulfate + H(2)O <=> phenol + sulfate.; Function: ars-1 from N. crassa catalyzes the hydrolysis of Sulfate esters.; Remark: N. crassa ars-1 gene is expressed under conditions of sulfur limitation.; Title: strong similarity to arylsulfatase gene ars-1 - Neurospora crassa; See PMID 2528685; uncharacterized protein 1214785 4988114 An15g05130 Aspergillus niger uncharacterized protein XP_059602555.1 1212792 R 5061 CDS An15g05150 4988116 1217775..1219295 III 1 NT_166530.1 Similarity: the ORF encoded protein shows also weak similarity to other transporter proteins.; Title: similarity to immunogenic protein #19915 from patent WO200181581-A2 - Propionibacterium acnes; uncharacterized protein 1219295 4988116 An15g05150 Aspergillus niger uncharacterized protein XP_001397045.1 1217775 D 5061 CDS An15g05160 84593209 complement(join(1219447..1219525,1219668..1219829,1219920..1219986,1220068..1220224,1220356..1220383,1220477..1220882,1220999..1221065,1221153..1221212)) III 1 NT_166530.1 Title: weak similarity to ORF 711 from patent WO9957280-A2 - Neisseria meningitidis; uncharacterized protein 1221212 84593209 An15g05160 Aspergillus niger uncharacterized protein XP_059602556.1 1219447 R 5061 CDS An15g05170 4988118 1221641..1222597 III 1 NT_166530.1 Catalytic activity: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate.; Cofactor: Pyridoxal-phosphate.; Remark: Some alkyl thiols, cyanide, pyrazole and some other heterocyclic compounds can act as acceptors.; Title: strong similarity to cysteine synthase cysK -Methanosarcina thermophila; cytoplasm; See PMID 10930739; uncharacterized protein 1222597 4988118 An15g05170 Aspergillus niger uncharacterized protein XP_001397047.1 1221641 D 5061 CDS An15g05180 4988119 complement(join(1222818..1224471,1224552..1224655)) III 1 NT_166530.1 hypothetical protein 1224655 4988119 An15g05180 Aspergillus niger hypothetical protein XP_059602557.1 1222818 R 5061 CDS An15g05190 84593210 complement(join(1226226..1226365,1226482..1226502,1226540..1226636,1226781..1226816)) III 1 NT_166530.1 hypothetical protein 1226816 84593210 An15g05190 Aspergillus niger hypothetical protein XP_059602558.1 1226226 R 5061 CDS An15g05200 4988121 complement(join(1227311..1227522,1227594..1228116)) III 1 NT_166530.1 Similarity: the ORF encoded protein shows also similarities to other methyltransferases.; Title: weak similarity to O-methyltransferase MdmC -Streptomyces mycarofaciens; uncharacterized protein 1228116 4988121 An15g05200 Aspergillus niger uncharacterized protein XP_059602559.1 1227311 R 5061 CDS An15g05210 84593211 complement(join(1228651..1228780,1228877..1229056,1229170..1229186)) III 1 NT_166530.1 hypothetical protein 1229186 84593211 An15g05210 Aspergillus niger hypothetical protein XP_059602560.1 1228651 R 5061 CDS An15g05220 84593212 join(1229521..1229607,1229655..1229900,1229948..1230274) III 1 NT_166530.1 Catalytic activity: 5,6,7,8-tetrahydrofolate + NADP(+) <=> 7,8-dihydrofolate + NADPH.; Function: the dihydrofolate reductase from animals and some microorganisms also slowly reduces folate to 5,6,7, 8-tetrahydrofolate.; Remark: essential step for de novo glycine and purine synthesis.; Title: similarity to dihydrofolate reductase dfr1p -Schizosaccharomyces pombe; See PMID 8088538; uncharacterized protein 1230274 84593212 An15g05220 Aspergillus niger uncharacterized protein XP_059602561.1 1229521 D 5061 CDS An15g05230 4988124 complement(1231108..1232106) III 1 NT_166530.1 Title: weak similarity to hypothetical protein encoded by mll5172 - Mesorhizobium loti; uncharacterized protein 1232106 4988124 An15g05230 Aspergillus niger uncharacterized protein XP_001397053.1 1231108 R 5061 CDS An15g05240 84593213 join(1232942..1233142,1233228..1233335,1233417..1233551) III 1 NT_166530.1 Title: weak similarity to hypothetical protein B14D6.120 - Neurospora crassa; uncharacterized protein 1233551 84593213 An15g05240 Aspergillus niger uncharacterized protein XP_059602562.1 1232942 D 5061 CDS An15g05250 4988126 join(1234062..1234348,1234388..1234931) III 1 NT_166530.1 Induction: human Hep27 is synthesized and accumulated in the nucleus of human hepatoblastoma (HepG2) cells, following growth arrest induced by butyrate treatment.; Remark: an alternative name for human Hep27 is protein D.; Similarity: human Hep27 is a putative member of the short-chain alcohol dehydrogenase enzymes (SCAD) family.; Title: similarity to nuclear protein Hep27 - Homo sapiens; nucleus; See PMID 7556196; uncharacterized protein 1234931 4988126 An15g05250 Aspergillus niger uncharacterized protein XP_059602563.1 1234062 D 5061 CDS An15g05260 4988127 complement(join(1235300..1237924,1237979..1238530)) III 1 NT_166530.1 Remark: The deletion spectrum at het-6 thus resembles other cases where mitotic deletions occur such as of tumor suppressor genes and of the hprt gene (coding for hypoxanthine-guanine phosphoribosyl-transferase) in humans.; Similarity: to heterokaryon incompatibility proteins.; Title: similarity to heterokaryon incompatibility protein het-6 - Neurospora crassa; See PMID 10880472; See PMID 11035941; uncharacterized protein 1238530 4988127 An15g05260 Aspergillus niger uncharacterized protein XP_059602564.1 1235300 R 5061 CDS An15g05270 4988128 complement(1239088..1241133) III 1 NT_166530.1 Catalytic activity: a carboxylic ester + H(2)O <=> an alcohol + a carboxylic anion.; Function: the carboxylesterase ES-4 from R. norvegicus also hydrolyses acetanilide and, distinctively,palmitoyl-CoA.; Function: the carboxylesterase ES-4 from R. norvegicus expressed in COS cells hydrolyses omicron-nitrophenyl acetate and alpha-naphthyl acetate.; Remark: changes in activity and expression of ES-4 from R. norvegicus correlate to thyroxine status in the rat suggesting a physiological regulatory role by this hormone.; Title: strong similarity to carboxylesterase precursor protein ES-4 - Rattus norvegicus; See PMID 10395963; See PMID 8611161; uncharacterized protein 1241133 4988128 An15g05270 Aspergillus niger uncharacterized protein XP_001397057.1 1239088 R 5061 CDS An15g05280 4988129 join(1241535..1241839,1241894..1241936,1241994..1242958,1243006..1243330) III 1 NT_166530.1 Catalytic activity: the F. oxysporum homolog PVA hydrolyses penicillin V (phenoxy-methylpenicillin) to 6-aminopenicillanic acid 6-APA).; Title: strong similarity to penicillin V amidohydrolase PVA from patent US5516679-A - Fusarium oxysporum; uncharacterized protein 1243330 4988129 An15g05280 Aspergillus niger uncharacterized protein XP_001397058.1 1241535 D 5061 CDS An15g05290 4988130 complement(join(1244072..1244790,1244842..1247623,1247679..1248482,1248551..1248874)) III 1 NT_166530.1 Function: S. cerevisiae Ybt1p transports bile acids in vitro.; Remark: alternative gene names for the S. cerevisiae homolog YLL048c are YBT1 and BAT1.; Similarity: belongs to the superfamily of ATP binding cassette (ABC) transporter.; Title: strong similarity to bile acid transporter Ybt1 - Saccharomyces cerevisiae; uncharacterized protein 1248874 4988130 An15g05290 Aspergillus niger uncharacterized protein XP_059602565.1 1244072 R 5061 CDS An15g05300 84593214 complement(join(1249975..1250001,1250088..1250122,1250153..1250162,1250193..1250403,1250451..1250609,1250670..1250686)) III 1 NT_166530.1 hypothetical protein 1250686 84593214 An15g05300 Aspergillus niger hypothetical protein XP_059602566.1 1249975 R 5061 CDS An15g05310 4988132 1250923..1252674 III 1 NT_166530.1 Function: the S. cerevisiae homolog Upc2p encodes a binucleate zinc cluster protein controlling expression of an anaerobic sterol transport system that is responsible for uptake and intracellular esterification of intracellular cholesterol.; Remark: alternative gene names for UPC2 are MOX4 and YDR213w.; Repression: S. cerevisiae Upc2p is heme-inhibited.; Title: strong similarity to RNA polymerase II transcription factor Upc2 - Saccharomyces cerevisiae; uncharacterized protein 1252674 4988132 An15g05310 Aspergillus niger uncharacterized protein XP_001397061.1 1250923 D 5061 CDS An15g05320 4988133 join(1253342..1253698,1253787..1253852,1253927..1254091) III 1 NT_166530.1 Title: similarity to hypothetical protein DR0703 -Deinococcus radiodurans; uncharacterized protein 1254091 4988133 An15g05320 Aspergillus niger uncharacterized protein XP_001397062.1 1253342 D 5061 CDS An15g05330 84593215 join(1254371..1254605,1254653..1254705,1254845..1255018,1255149..1255321,1255352..1255435,1255518..1255638) III 1 NT_166530.1 hypothetical protein 1255638 84593215 An15g05330 Aspergillus niger hypothetical protein XP_059602567.1 1254371 D 5061 CDS An15g05340 84593216 join(1255866..1255919,1256136..1256589,1256694..1256824) III 1 NT_166530.1 hypothetical protein 1256824 84593216 An15g05340 Aspergillus niger hypothetical protein XP_059602568.1 1255866 D 5061 CDS An15g05350 4988136 join(1257322..1258121,1258193..1258487,1258738..1258775,1258829..1259027) III 1 NT_166530.1 Function: S. cerevisiae Crh1p is a putative glycosidases involved in cell wall biogenesis.; Induction: transcription of Crh1p is cell cycle dependent.; Similarity: the S. cerevisiae homolog Crh1p shows similarity with various bacterial beta-glucanases and eukaryotic endotransglycosidases.; Title: strong similarity to cell wall protein Crh1 -Saccharomyces cerevisiae; plasma membrane; uncharacterized protein 1259027 4988136 An15g05350 Aspergillus niger uncharacterized protein XP_001397065.3 1257322 D 5061 CDS An15g05360 4988137 join(1259346..1259388,1259450..1259661,1259732..1259882,1259957..1260289,1260345..1260604) III 1 NT_166530.1 Title: similarity to actVA-ORF4-like protein from patent WO9911793-A1 - Homo sapiens; uncharacterized protein 1260604 4988137 An15g05360 Aspergillus niger uncharacterized protein XP_001397066.1 1259346 D 5061 CDS An15g05370 4988138 complement(join(1261383..1261841,1261894..1262523)) III 1 NT_166530.1 Catalytic activity: catalyzes the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans.; Function: pgaII encodes the A. niger polygalacturonase (pectinase).; Gene-ID: pgaII;pgx2; polygalacturonase pgaII-Aspergillus niger 1262523 pgaII 4988138 pgaII Aspergillus niger polygalacturonase pgaII-Aspergillus niger XP_001397067.1 1261383 R 5061 CDS An15g05380 84593217 join(1263017..1263159,1263284..1263427,1263503..1263619,1263668..1263773) III 1 NT_166530.1 Remark: this hypothetical orf is most likely the prepro-region of the following gene identical to A. niger PGII.; hypothetical protein 1263773 84593217 An15g05380 Aspergillus niger hypothetical protein XP_059602569.1 1263017 D 5061 CDS An15g05390 84593218 complement(join(1264066..1264220,1264340..1264402,1264660..1264712,1264810..1265025,1265101..1265228)) III 1 NT_166530.1 hypothetical protein 1265228 84593218 An15g05390 Aspergillus niger hypothetical protein XP_059602570.1 1264066 R 5061 CDS An15g05400 4988141 1265903..1266586 III 1 NT_166530.1 hypothetical protein 1266586 4988141 An15g05400 Aspergillus niger hypothetical protein XP_001397070.1 1265903 D 5061 CDS An15g05410 4988142 1267168..1267611 III 1 NT_166530.1 Function: belongs to a family of low-molecular-weight HSPs related to stress response and protein folding.; Title: strong similarity to heat-shock protein hsp30 - Aspergillus nidulans; uncharacterized protein 1267611 4988142 An15g05410 Aspergillus niger uncharacterized protein XP_001397071.1 1267168 D 5061 CDS An15g05430 84593219 complement(join(1268396..1268496,1268532..1268671,1268775..1268870,1268956..1269035,1269126..1269252,1269310..1269373,1269452..1269758)) III 1 NT_166530.1 hypothetical protein 1269758 84593219 An15g05430 Aspergillus niger hypothetical protein XP_059606528.1 1268396 R 5061 CDS An15g05440 4988145 join(1269909..1270113,1270170..1271503) III 1 NT_166530.1 Phenotype: Disruption strains showed much-reduced uptake of glucose at low concentrations and growth was particularly affected in low-glucose medium.; Similarity: the ORF encoded protein also shows similarity to other hexose transporters.; Title: strong similarity to high-affinity glucose transporter HGT1 - Kluyveromyces lactis; plasma membrane; putative frameshift; See PMID 8830679; uncharacterized protein 1271503 4988145 An15g05440 Aspergillus niger uncharacterized protein XP_001397073.1 1269909 D 5061 CDS An15g05450 4988146 complement(1272241..1273041) III 1 NT_166530.1 Catalytic activity: R-CHOH-R' + NADP(+) <=> R-CO-R' + NADPH.; Remark: the carbonyl reductase from Candida magnoliae is also described in patent WO9835025-A1.; Similarity: the ORF encoded protein shows also strong similarity to the functionally less characterized dehydrogenases Sou2 and Sou1 from C. albicans. C. albicans Sou(-) mutants are unable to utilize L-sorbose.; Title: strong similarity to NADPH-dependent carbonyl reductase S1 - Candida magnoliae; See PMID 10945260; uncharacterized protein 1273041 4988146 An15g05450 Aspergillus niger uncharacterized protein XP_001397074.1 1272241 R 5061 CDS An15g05460 4988147 join(1273471..1273559,1273620..1273736,1273784..1273837,1273885..1275325) III 1 NT_166530.1 Remark: S. cerevisiae cells expressing Tpo1 become resistant to polyamine toxicity,the resistance was overcome by bafilomycin A1, an inhibitor of vacuolar H+-ATPase.; Remark: alternate name for S. cerevisiae Tpo1: YLL028w.; Similarity: the ORF encoded protein shows also similarity to a protein involved in cephalosporin C biosynthesis of patent JP09009966-A.; Title: strong similarity to polyamine transport protein Tpo1 - Saccharomyces cerevisiae; vacuole; See PMID 9920864; uncharacterized protein 1275325 4988147 An15g05460 Aspergillus niger uncharacterized protein XP_001397075.1 1273471 D 5061 CDS An15g05470 4988148 complement(join(1275413..1275932,1275999..1276093,1276156..1276491)) III 1 NT_166530.1 Title: similarity to hypothetical protein BH0305 -Bacillus halodurans; uncharacterized protein 1276491 4988148 An15g05470 Aspergillus niger uncharacterized protein XP_001397076.1 1275413 R 5061 CDS An15g05480 84593220 join(1278425..1278744,1278791..1278815) III 1 NT_166530.1 hypothetical protein 1278815 84593220 An15g05480 Aspergillus niger hypothetical protein XP_059606529.1 1278425 D 5061 CDS An15g05490 4988150 complement(join(1279559..1279922,1279974..1280212,1280262..1280723,1280783..1281099,1281149..1281603,1281660..1281856)) III 1 NT_166530.1 Title: strong similarity to hypothetical protein encoded by An02g01140 - Aspergillus niger; uncharacterized protein 1281856 4988150 An15g05490 Aspergillus niger uncharacterized protein XP_059606530.1 1279559 R 5061 CDS An15g05500 4988151 complement(join(1283402..1284120,1284153..1284504,1284590..1284711,1284782..1285131,1285185..1285561,1285612..1286061)) III 1 NT_166530.1 Induction: CFL1 transcription in C. albicans is regulated in response to levels of iron and copper.; Title: similarity to ferric reductase cfl1 - Candida albicans; See PMID 10784045; uncharacterized protein 1286061 4988151 An15g05500 Aspergillus niger uncharacterized protein XP_059606531.1 1283402 R 5061 CDS An15g05510 4988152 complement(1287398..1288531) III 1 NT_166530.1 Induction: CaFTR2 expression was repressed under iron-limited conditions and induced when iron supply was sufficient.; Similarity: CaFTR2 from C. albicans is a high-affinity iron permease; Title: strong similarity to high-affinity iron permease CaFTR2 - Candida albicans; plasma membrane; See PMID 10807578; uncharacterized protein 1288531 4988152 An15g05510 Aspergillus niger uncharacterized protein XP_001397080.1 1287398 R 5061 CDS An15g05520 4988153 1288878..1290743 III 1 NT_166530.1 Cofactor: copper.; Function: fet3 from C. albicans is an essential component of copper-dependent iron transport.; Function: fet3 from C. albicans is an iron transport multicopper ferroxidase required for ferrous iron high affinity uptake.; Phenotype: the fet3 deletion mutant of C. albicans was unable to grow in low-iron medium.; Similarity: fet3 from C. albicans belongs to the multicopper oxidase family (TC 9. A. 10).; Title: strong similarity to iron transport multicopper oxidase Fet3 - Candida albicans; plasma membrane; See PMID 10517594; uncharacterized protein 1290743 4988153 An15g05520 Aspergillus niger uncharacterized protein XP_059606532.1 1288878 D 5061 CDS An15g05530 4988154 complement(join(1291404..1291477,1291580..1291691,1291763..1291876,1291941..1293053,1293151..1293345)) III 1 NT_166530.1 Function: FLU1 in C. albicans is a multidrug efflux transporter gene of the major facilitator superfamily.; Phenotype: expression of FLU1 in C. albicans mediated not only resistance to fluconazole but also to cycloheximide.; Phenotype: the disruption of FLU1 in C. albicans had only a slight effect on fluconazole susceptibility but resulted in hypersusceptibility to mycophenolic acid.; Phenotype: the disruption of FLU1 in a background of C. albicans mutants with deletions in several multidrug efflux transporter genes, including CDR1, CDR2 and CaMDR1,resulted in enhanced susceptibility to several azole derivatives.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353; uncharacterized protein 1293345 4988154 An15g05530 Aspergillus niger uncharacterized protein XP_001397082.3 1291404 R 5061 CDS An15g05540 4988155 complement(join(1293709..1293792,1293849..1293964,1294014..1294041,1294090..1294287,1294339..1294553,1294603..1294746,1294797..1295128,1295191..1295298,1295388..1295533)) III 1 NT_166530.1 Function: the gene product of the mtr locus of N. crassa is required for the transport of neutral aliphatic and aromatic amino acids via the N system.; Title: strong similarity to neutral amino acid permease mtr - Neurospora crassa; plasma membrane; See PMID 1838345; uncharacterized protein 1295533 4988155 An15g05540 Aspergillus niger uncharacterized protein XP_059606533.1 1293709 R 5061 CDS An15g05550 4988156 complement(1296313..1297716) III 1 NT_166530.1 Title: weak similarity to neuronal apoptosis inhibitory protein Naip1 - Mus musculus; uncharacterized protein 1297716 4988156 An15g05550 Aspergillus niger uncharacterized protein XP_001397084.1 1296313 R 5061 CDS An15g05560 84593221 1297981..1298334 III 1 NT_166530.1 Similarity: the ORF encoded protein shows also weak similarities to other proteins, which are based on repetetive structures.; Title: similarity to EST Nig004 - Aspergillus niger; uncharacterized protein 1298334 84593221 An15g05560 Aspergillus niger uncharacterized protein XP_059606534.1 1297981 D 5061 CDS An15g05570 84593222 join(1299243..1299256,1299393..1299507) III 1 NT_166530.1 Title: questionable ORF; uncharacterized protein 1299507 84593222 An15g05570 Aspergillus niger uncharacterized protein XP_059606535.1 1299243 D 5061 CDS An15g05580 4988159 complement(1300405..1301280) III 1 NT_166530.1 Function: the fused gene Lux::npt-II with comprises a gene conferring conditional growth advantage and a marker gene, used as a probe to select and isolate genetic elements.; Remark: the matched sequence is that of a fusion protein encoded by the firefly (P. pyralis) luciferase:neomycin phosphotransferase-II chimeric gene.; Title: similarity to Lux/npt-II fusion protein from patent WO9217593-A - synthetic; uncharacterized protein 1301280 4988159 An15g05580 Aspergillus niger uncharacterized protein XP_001397087.1 1300405 R 5061 CDS An15g05590 84593223 complement(join(1302857..1302898,1303009..1303189,1303258..1303439)) III 1 NT_166530.1 Title: weak similarity to protein fragment SEQ ID NO:13253 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 1303439 84593223 An15g05590 Aspergillus niger uncharacterized protein XP_059606536.1 1302857 R 5061 CDS An15g05600 84593224 complement(1303680..1303886) III 1 NT_166530.1 Title: weak similarity to indole-3-glycerol phosphate synthase - Staphylococcus aureus; uncharacterized protein 1303886 84593224 An15g05600 Aspergillus niger uncharacterized protein XP_059606537.1 1303680 R 5061 CDS An15g05610 4988162 complement(join(1304179..1304501,1304556..>1305540)) III 1 NT_166530.1 Remark: the ORF is truncated and contains no start codon, due to the end of the contig.; Title: weak similarity to polypeptide SEQ ID NO:1833 from patent WO200171042-A2 - Drosophila melanogaster; uncharacterized protein 1305540 4988162 An15g05610 Aspergillus niger uncharacterized protein XP_001397090.3 1304179 R 5061 CDS An15g05620 84593225 join(1306154..1306322,1306375..1307084) III 1 NT_166530.1 hypothetical protein 1307084 84593225 An15g05620 Aspergillus niger hypothetical protein XP_059602571.1 1306154 D 5061 CDS An15g05630 4988164 complement(join(1308031..1310478,1310554..1312260,1312340..1313308)) III 1 NT_166530.1 Function: co-expression of het-e and het-c lead to cell death.; Function: het-e1 of P. anserina is responsible for vegetative incompatibility.; Remark: the reactivity of the HET-E protein depends on two functional elements, a GTP-binding domain and several WD40 repeats.; Similarity: contains 12 WD40-like repeats.; Similarity: the A. niger protein, like het-e1 of P. anserina, contains both a GTP-binding domain and a WD40-repeat domain reminiscent of G-protein alpha and beta subunits, respectively.; Title: similarity to vegetative heterokaryon incompatibility factor het-e1 - Podospora anserina; See PMID 7557402; See PMID 9435787; See PMID 10875280; See PMID 10974123; uncharacterized protein 1313308 4988164 An15g05630 Aspergillus niger uncharacterized protein XP_059602572.1 1308031 R 5061 CDS An15g05640 84593226 complement(join(1313536..1313710,1313823..1314301)) III 1 NT_166530.1 hypothetical protein 1314301 84593226 An15g05640 Aspergillus niger hypothetical protein XP_059602573.1 1313536 R 5061 CDS An15g05650 4988166 join(1315741..1316018,1316080..1316408,1316469..1316770,1316858..1317020,1317075..1317253) III 1 NT_166530.1 Function: SRPK2 of H. sapiens specifically phosphorylates the SR family of splicing factors involved in spliceosome assembly and alternative splicing regulation.; Title: strong similarity to SR-protein-specific serine kinase SRPK2 - Homo sapiens; See PMID 9472028; uncharacterized protein 1317253 4988166 An15g05650 Aspergillus niger uncharacterized protein XP_001397094.1 1315741 D 5061 CDS An15g05660 4988167 complement(join(1317533..1317674,1317742..1317770,1317828..1317944)) III 1 NT_166530.1 Title: questionable ORF; uncharacterized protein 1317944 4988167 An15g05660 Aspergillus niger uncharacterized protein XP_001397095.1 1317533 R 5061 CDS An15g05670 4988168 1320622..1322505 III 1 NT_166530.1 Catalytic activity: N,N-Dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP(+) + H2O.; Title: strong similarity to flavin-containing monooxygenase 1C1 - Oryctolagus cuniculus; See PMID 8486656; uncharacterized protein 1322505 4988168 An15g05670 Aspergillus niger uncharacterized protein XP_001397096.3 1320622 D 5061 CDS An15g05680 4988169 complement(join(1323524..1323590,1323732..1323887,1323985..1324022,1324117..1324122)) III 1 NT_166530.1 Complex: the Sm proteins B', B, D1, D2, D3, E, F and G constitute the core of the spliceosomal ribonucleoprotein particles U1, U2, U4/U6 and U5.; Function: the Sm proteins are necessary for spliceosome assembly.; Function: the Sm proteins interact with the Sm site present in four of the major spliceosomal small nuclear RNAs.; Title: strong similarity to Sm-type small nuclear ribonucleoprotein F - Homo sapiens; nucleus; See PMID 7744013; uncharacterized protein 1324122 4988169 An15g05680 Aspergillus niger uncharacterized protein XP_001397097.1 1323524 R 5061 CDS An15g05690 4988170 complement(join(1324696..1324839,1324956..1325078,1325170..1325235,1325300..1325414,1325569..1325603)) III 1 NT_166530.1 Similarity: also shows strong similarity to the Aspergillus oryzae EST SEQ ID NO:4834 of the DNA patent WO200056762-A2 (PATENTDNA:AAF12311).; Title: strong similarity to hypothetical conserved protein SPBC2D10.03c - Schizosaccharomyces pombe; uncharacterized protein 1325603 4988170 An15g05690 Aspergillus niger uncharacterized protein XP_001397098.1 1324696 R 5061 CDS An15g05700 4988171 join(1327302..1327360,1327420..1327993,1328049..1328653,1328858..1328918,1328991..1329275) III 1 NT_166530.1 Title: similarity to hypothetical protein CAB91732.2 - Neurospora crassa; uncharacterized protein 1329275 4988171 An15g05700 Aspergillus niger uncharacterized protein XP_001397099.3 1327302 D 5061 CDS An15g05710 4988172 join(1330230..1331249,1331310..1332630,1332688..1332825,1332882..1333357) III 1 NT_166530.1 Catalytic activity: phosphatidic acid (derivative) + H2O = 2-acylphosphoglyceride (derivative) + fatty acid.; Title: strong similarity to hypothetical phosphatidic acid-preferring phospholipase A1 B14D6.220 -Neurospora crassa; uncharacterized protein 1333357 4988172 An15g05710 Aspergillus niger uncharacterized protein XP_059602574.1 1330230 D 5061 CDS An15g05720 4988173 complement(join(1333743..1335208,1335314..1335538,1335593..1335630,1335692..1335732,1335786..1336190)) III 1 NT_166530.1 Function: gephyrin of R. norvegicus binds with high affinity to molybdopterin, the metabolic precursor of the molybdenum cofactor.; Function: gephyrin of R. norvegicus catalyzes the final step in the biosynthesis of the molybdenum cofactor,the insertion of molybdenum into molybdopterin.; Function: gephyrin of R. norvegicus forms a submembraneous scaffold for anchoring inhibitory neurotransmitter receptors in the postsynaptic membrane to subsynaptic microtubules.; Function: gephyrin of R. norvegicus is able to reconstitute molybdenum cofactor (MoCo) biosynthesis in Moco-deficient bacteria, a molybdenum-dependent mouse cell line, and a Moco-deficient plant mutant.; Function: the molybdenum cofactor biosynthesis enzyme Cnx1 of A. thaliana binds to the cytoskeleton in the same way that its mammalian homolog gephyrin does in neuronal cells.; Similarity: also shows strong similarity to the molybdenum cofactor biosynthesis enzyme Cnx1 of Arabidopsis thaliana.; Title: strong similarity to postsynaptic receptor clustering and molybdenum cofactor biosynthesis protein gephyrin - Rattus norvegicus; See PMID 9990024; See PMID 11325967; uncharacterized protein 1336190 4988173 An15g05720 Aspergillus niger uncharacterized protein XP_059602575.1 1333743 R 5061 CDS An15g05730 4988174 complement(join(1336520..1336628,1336682..1336990,1337053..1337144,1337203..1337237,1337309..1337366)) III 1 NT_166530.1 Complex: Vma16p of S. cerevisiae forms part of the membrane-embedded multi-subunit V0-complex of vacuolar H(+)-transporting ATPase.; Function: Vma16p of S. cerevisiae is involved in the assembly of the V0V1-complex of vacuolar H(+)-transporting ATPase.; Function: Vma16p of S. cerevisiae is required for H(+)-transport activity of the vacuolar H(+)-transporting ATPase.; Function: vacuolar H(+)-transporting ATPase is required for the acidification of the vacuolar lumen.; Localization: Vma16p of S. cerevisiae is incorporated into the vacuolar membrane.; Remark: an alternative name for VMA16 of S. cerevisiae is PPA1.; Title: strong similarity to vacuolar H(+)-transporting ATPase V0-complex proteolipid subunit c Vma16 - Saccharomyces cerevisiae; vacuole; See PMID 9030535; uncharacterized protein 1337366 4988174 An15g05730 Aspergillus niger uncharacterized protein XP_001397102.1 1336520 R 5061 CDS An15g05740 4988175 join(1337888..1337940,1338002..1338027,1338096..1338184,1338314..1338716,1338781..1338839) III 1 NT_166530.1 Function: Rab6 of H. sapiens is probably involved in vesicle traffic targeting.; Similarity: belongs to the ras superfamily.; Title: strong similarity to GTP-binding protein Rab6 - Homo sapiens; See PMID 2501306; uncharacterized protein 1338839 4988175 An15g05740 Aspergillus niger uncharacterized protein XP_001397103.1 1337888 D 5061 CDS An15g05750 4988176 join(1339812..1339841,1339871..1340165,1340214..1341280) III 1 NT_166530.1 Title: similarity to hypothetical protein SPAC26H5.13c - Schizosaccharomyces pombe; uncharacterized protein 1341280 4988176 An15g05750 Aspergillus niger uncharacterized protein XP_059602576.1 1339812 D 5061 CDS An15g05760 84593227 complement(join(1342240..1342317,1342528..1342764,1342912..1342974)) III 1 NT_166530.1 hypothetical protein 1342974 84593227 An15g05760 Aspergillus niger hypothetical protein XP_059602577.1 1342240 R 5061 CDS An15g05770 4988178 join(1343031..1343061,1343171..1343310,1343372..1343920,1344086..1347754,1347814..1347843) III 1 NT_166530.1 Function: four conserved cystein residues in the sulphite reductase domain are required for binding of a 4Fe4S cluster and a siroheme as cofactors.; Function: the protein is likely to incorporate a flavodoxin oxidoreductase (electron donor undetermined), a flavodoxin electron transfer domain and a sulfite reductase catalytic domain.; Similarity: the C-terminus is highly similar to a variety of sulphite reductases.; Similarity: the N-terminus is similar to pyruvate:ferrodoxin/flavodoxin oxidoreductases.; Similarity: the middle domain is homologous to FMN-containing flavodoxins.; Title: strong similarity to hypothetical sulphite reductase SPAC4C5.05c - Schizosaccharomyces pombe; uncharacterized protein 1347843 4988178 An15g05770 Aspergillus niger uncharacterized protein XP_059602578.1 1343031 D 5061 CDS An15g05780 4988180 join(1348365..1348614,1348714..1348827,1348909..1349180,1349253..1349477) III 1 NT_166530.1 Complex: RPC37 of S. cerevisiae is the RNA Polymerase C (III) 37 kDa subunit and interacts with the C53 subunit.; Function: RNA polymerase III is necessary for the transcription of tRNAs, the 5S rRNA and other small stable RNAs.; Remark: RPC37 of S. cerevisiae is also called YKR025w.; Similarity: the C-terminal region of the predicted protein shows no similarity.; Title: strong similarity to 37 kD subunit of DNA-directed RNA polymerase III Rpc37 - Saccharomyces cerevisiae; nucleus; See PMID 9159472; See PMID 10375630; See PMID 10393904; uncharacterized protein 1349477 4988180 An15g05780 Aspergillus niger uncharacterized protein XP_059602579.1 1348365 D 5061 CDS An15g05790 84593228 join(1350265..1351083,1351142..1354426) III 1 NT_166530.1 Regulation: RPO1 of S. cerevisiae is subject to catabolite repression.; Remark: mitochondrial RNA polymerases have also been assigned the role of a primase in the replication of mtDNA.; Similarity: RPO41 of S. cerevisiae and the predicted protein show similarity to bacteriophage-coded RNA polymerases.; Title: strong similarity to mitochondrial DNA-directed RNA polymerase Rpo41 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 3308116; See PMID 3517858; See PMID 2152961; See PMID 2677667; See PMID 3045116; uncharacterized protein 1354426 84593228 An15g05790 Aspergillus niger uncharacterized protein XP_059602580.1 1350265 D 5061 CDS An15g05800 84593229 complement(join(1355057..1355241,1355364..1355492,1355588..1355736,1355825..1355904)) III 1 NT_166530.1 Remark: the ORF is classified as questionable because it has no similarity and is located, on the opposite strand, in region corresponding to the 5'-UTR of the following A. niger xylR transcript.; Title: questionable ORF; uncharacterized protein 1355904 84593229 An15g05800 Aspergillus niger uncharacterized protein XP_059602581.1 1355057 R 5061 CDS An15g05810 4988182 join(1356148..1356373,1356438..1358695,1358750..1358893) III 1 NT_166530.1 Function: the transcriptional activator XlnR regulates both xylanolytic and endoglucanase gene expression in A. niger, constituting a key factor allowing A. niger to harmonize its sugar metabolism and extracellular xylan degradation through regulation of gene expression.; Gene-ID: xlnR;xylR; Mapping: xlnR from A. niger is mapped to chromosome III (LG III); see list from DSM, EMBL AJ001909.; nucleus; See PMID 9466262; See PMID 9758775; See PMID 10376490; See PMID 10508057; See PMID 10760176; xylanolytic transcriptional activator xlnR-Aspergillus niger 1358893 xlnR 4988182 xlnR Aspergillus niger xylanolytic transcriptional activator xlnR-Aspergillus niger XP_001397110.3 1356148 D 5061 CDS An15g05820 4988183 join(1359342..1359746,1359813..1360340,1360389..1360514) III 1 NT_166530.1 Similarity: many of the hypothetical proteins showing similarity to the predicted ORF are annotated as pyruvate formate-lyase activating enzyme; the predicted protein shows only a stretch of 31 residues with 41% identity to the first enzymatically characterized pyruvate formate-lyase activating enzyme (of E. coli), then nothing can be concluded about its enzymatic activity or function.; Title: strong similarity to hypothetical conserved protein aq_729 - Aquifex aeolicus; uncharacterized protein 1360514 4988183 An15g05820 Aspergillus niger uncharacterized protein XP_059602582.1 1359342 D 5061 CDS An15g05830 84593230 join(1362374..1362633,1363013..1363310,1363643..1363999) III 1 NT_166530.1 hypothetical protein 1363999 84593230 An15g05830 Aspergillus niger hypothetical protein XP_059602583.1 1362374 D 5061 CDS An15g05840 4988185 complement(join(1365421..1365547,1365720..1367339,1367515..1367708,1367760..1368273,1368341..1368369,1368426..1368476)) III 1 NT_166530.1 Similarity: the first three exons of the predicted protein correspond to A. niger EST SEQ ID NO:4205 of patent WO200056762-A2.; Title: similarity to hypothetical protein CAC28841.2 - Neurospora crassa; uncharacterized protein 1368476 4988185 An15g05840 Aspergillus niger uncharacterized protein XP_001397113.3 1365421 R 5061 CDS An15g05850 4988186 join(1369146..1369331,1369394..1369611,1369673..1370045,1370080..1370442) III 1 NT_166530.1 Similarity: the C-terminal region of the predicted protein shows no similarity.; Title: similarity to hypothetical protein AAH08596.1 - Homo sapiens; uncharacterized protein 1370442 4988186 An15g05850 Aspergillus niger uncharacterized protein XP_059602584.1 1369146 D 5061 CDS An15g05860 84593231 complement(1370714..1371922) III 1 NT_166530.1 Similarity: the similarity to F12F6. 5 of C. elegans is due to a very short stretch of quite well conserved amino acids.; Title: weak similarity to hypothetical protein F12F6.5 - Caenorhabditis elegans; uncharacterized protein 1371922 84593231 An15g05860 Aspergillus niger uncharacterized protein XP_059602585.1 1370714 R 5061 CDS An15g05870 84593232 complement(join(1372540..1372636,1372776..1373158)) III 1 NT_166530.1 Title: weak similarity to hypothetical protein AAH07476.1 - Mus musculus; uncharacterized protein 1373158 84593232 An15g05870 Aspergillus niger uncharacterized protein XP_059602586.1 1372540 R 5061 CDS An15g05880 4988189 join(1373457..1373752,1373823..1374502,1374612..1374827,1374892..1375764,1375912..1376103,1376151..1376232,1376280..1376346) III 1 NT_166530.1 Title: strong similarity to hypothetical protein SPBC1604.01 - Schizosaccharomyces pombe; uncharacterized protein 1376346 4988189 An15g05880 Aspergillus niger uncharacterized protein XP_059602587.1 1373457 D 5061 CDS An15g05890 4988190 join(1376658..1377959,1378018..1378131) III 1 NT_166530.1 Catalytic activity: aldehyde dehydrogenase catalyzes the NAD-dependent conversion of an aldehyde to the corresponding carboxylate.; Similarity: the predicted protein shows similarity to several aldehyde dehydrogenases from different species,and to different isoforms of the enzyme within single organisms; such enzymes show often a variety of different substrate specificities, of subcellular localization and tissue distribution.; Title: strong similarity to aldehyde dehydrogenase AHD-M1 - Mus musculus; See PMID 8058062; uncharacterized protein 1378131 4988190 An15g05890 Aspergillus niger uncharacterized protein XP_001397118.1 1376658 D 5061 CDS An15g05900 84593233 complement(join(1379245..1379300,1379392..1379456,1379566..1379612,1379808..1379937,1380038..1380061,1380108..1380131,1380383..1380428,1380842..1380867,1381028..1381332)) III 1 NT_166530.1 Title: questionable ORF; uncharacterized protein 1381332 84593233 An15g05900 Aspergillus niger uncharacterized protein XP_059602588.1 1379245 R 5061 CDS An15g05910 4988192 complement(join(1381788..1382688,1382754..1382799,1382879..1383092)) III 1 NT_166530.1 hypothetical protein 1383092 4988192 An15g05910 Aspergillus niger hypothetical protein XP_001397120.1 1381788 R 5061 CDS An15g05920 4988193 complement(join(1383771..1383917,1384008..1384155,1384211..1384251)) III 1 NT_166530.1 Function: TOA2 from S. cerevisiae is necessary for the basal transcription machinery of RNA polymerase II; by binding to TATA binding protein (TBP) transcription is initiated from the Pol II promoter.; Phenotype: the S. cerevisiae TOA2 null mutant is inviable.; Remark: the systematic name of TOA2 from S. cerevisiae is YKL058W.; Similarity: the ORF overlaps with A. niger EST (PATENTDNA:AAF11372) SEQ ID NO:3895.; Title: strong similarity to small subunit of transcription factor TFIIA Toa2 - Saccharomyces cerevisiae; nucleus; See PMID 10692576; uncharacterized protein 1384251 4988193 An15g05920 Aspergillus niger uncharacterized protein XP_001397121.1 1383771 R 5061 CDS An15g05930 4988194 join(1384454..1384571,1384637..1384836,1384891..1384911,1384971..1385022,1385075..1385307) III 1 NT_166530.1 Remark: A. niger EST an_3119 has the database entry number EMBLEST:BE758865.; Similarity: additionally, the ORF overlaps with a short part of A. niger EST (EMBLEST:BE759083) an_3391.; Title: strong similarity to EST an_3119 -Aspergillus niger; uncharacterized protein 1385307 4988194 An15g05930 Aspergillus niger uncharacterized protein XP_001397122.3 1384454 D 5061 CDS An15g05940 4988195 complement(join(1385434..1386676,1386764..1387395)) III 1 NT_166530.1 Function: in addition to their catalytic role,hexokinases are thought to be involved in triggering carbon catabolite repression.; Phenotype: mutations in the A. nidulans xprF (and xprG) genes have been shown to result in elevated levels of extracellular protease in response to carbon limitation.; Remark: a splice site was detected upstream of the START codon.; Remark: no loss of glucose or fructose phosphorylating activity was detected in A. nidulans xprF1 or xprF2 mutants, which could mean, that (1) the xprF gene may encode a minor hexokinase or (2) the xprF gene may encode a protein with no hexose phosphorylating activity.; Similarity: the ORF overlaps with A. niger EST (EMBLEST:BE759083) an_3391.; Title: strong similarity to hexokinase-like protein xprF - Aspergillus nidulans; See PMID 11102357; uncharacterized protein 1387395 4988195 An15g05940 Aspergillus niger uncharacterized protein XP_001397123.1 1385434 R 5061 CDS An15g05950 84593234 join(1387698..1387739,1387784..1387823,1387925..1388124,1388352..1388479,1388562..1388691,1389290..1389462,1389669..1389753,1389936..1390208,1390286..1390374,1390472..1390679) III 1 NT_166530.1 Title: questionable ORF; uncharacterized protein 1390679 84593234 An15g05950 Aspergillus niger uncharacterized protein XP_059602589.1 1387698 D 5061 CDS An15g05960 4988197 join(1391351..1391805,1391864..1392386) III 1 NT_166530.1 Similarity: the predicted protein shows also weak similarity to a D. melanogaster hypothetical protein with unknown function.; Title: weak similarity to hypothetical protein AAF54945.1 - Drosophila melanogaster; uncharacterized protein 1392386 4988197 An15g05960 Aspergillus niger uncharacterized protein XP_001397125.1 1391351 D 5061 CDS An15g05970 4988198 1392985..1393947 III 1 NT_166530.1 hypothetical protein 1393947 4988198 An15g05970 Aspergillus niger hypothetical protein XP_001397126.1 1392985 D 5061 CDS An15g05980 4988199 join(1394415..1394775,1394866..1395536,1395724..1396125,1396377..1396387,1396499..1396565) III 1 NT_166530.1 Function: the S. cerevisiae TNA1 transporter is involved in the uptake of nicotinic acid.; Remark: TNA1 of S. cerevisiae is also called YGR260w.; Similarity: the C-terminal part of the predicted protein shows only weak similarity to TNA1.; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10649454; See PMID 10869563; See PMID 10984621; uncharacterized protein 1396565 4988199 An15g05980 Aspergillus niger uncharacterized protein XP_059602590.1 1394415 D 5061 CDS An15g05990 4988200 complement(join(1396972..1397651,1397724..1398006)) III 1 NT_166530.1 Catalytic activity: D-arabinitol + NAD+ = D-ribulose + NADH.; Catalytic activity: xylitol, D-glucitol and galactitol can also acts as substrates for ARDH of P. stipitis.; Complex: ARDH of P. stipitis is a homotetramer.; Similarity: ARDH of P. stipitis belongs to the short-chain dehydrogenase family; the predicted protein shows similarity also to other members of this family, thus another substrate specificity cannot be excluded.; Title: strong similarity to D-arabinitol 2-dehydrogenase ARDH - Pichia stipitis; See PMID 7483848; uncharacterized protein 1398006 4988200 An15g05990 Aspergillus niger uncharacterized protein XP_001397128.1 1396972 R 5061 CDS An15g06000 84593235 join(1398121..1398387,1398607..1398729,1398819..1398919,1399026..1399218) III 1 NT_166530.1 hypothetical protein 1399218 84593235 An15g06000 Aspergillus niger hypothetical protein XP_059602591.1 1398121 D 5061 CDS An15g06010 4988202 complement(1400495..1402888) III 1 NT_166530.1 Function: human 76p is involved in microtubule nucleation.; Localization: human 76p is located at the centrosome; the similarity is too weak to draw conclusions about the localization of the predicted protein.; Similarity: the similarity to human 76p is limited to the N-terminal part of the predicted protein and shows significant gaps.; Title: similarity to gamma tubulin ring complex protein 76p - Homo sapiens; See PMID 10562286; uncharacterized protein 1402888 4988202 An15g06010 Aspergillus niger uncharacterized protein XP_001397130.1 1400495 R 5061 CDS An15g06020 4988203 join(1403812..1403817,1403877..1403965,1404034..1404119,1404171..1406955,1407012..1407150) III 1 NT_166530.1 Catalytic activity: ATP + ubiquitin + protein lysine = AMP + pyrophosphate + protein N-ubiquityllysine.; Function: UBA1 of S. cerevisiae activates ubiquitin by first adenylating with ATP its carboxy-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thiolester and free AMP; thereafter the ubiquitin is transferred to any of a number of ubiquitin-conjugating E2 enzymes.; Pathway: first step in ubiquitin conjugation.; Title: strong similarity to ubiquitin activating protein Uba1 - Saccharomyces cerevisiae; See PMID 7629121; See PMID 8982460; See PMID 1989885; uncharacterized protein 1407150 4988203 An15g06020 Aspergillus niger uncharacterized protein XP_001397131.3 1403812 D 5061 CDS An15g06030 4988204 join(1407713..1407718,1407791..1407959,1408026..1408112,1408171..1408346,1408409..1408981) III 1 NT_166530.1 Function: ECM4 of S. cerevisiae is involved in cell wall biogenesis and architecture.; Remark: ECM4 of S. cerevisiae is also called YKR076w.; Title: strong similarity to hypothetical protein Ecm4 - Saccharomyces cerevisiae; See PMID 9159472; See PMID 9335584; uncharacterized protein 1408981 4988204 An15g06030 Aspergillus niger uncharacterized protein XP_001397132.3 1407713 D 5061 CDS An15g06040 4988205 complement(join(1409675..1410194,1410257..1410289,1410343..1410446,1410504..1410565,1410615..1411234,1411300..1411507,1411600..1411680,1411750..1411879)) III 1 NT_166530.1 Localization: the rabbit Ca-dependent carrier is mainly located in the peroxisomal membrane, although a minor fraction is found in the mitochondria; the Ca2+ binding N-terminal half of the transporter faces the cytosol.; Similarity: the C-terminal part of these proteins has strong similarity to mitochondrial carrier proteins,that have a variety of substrate specificities and that are involved in energy transfer in the inner mitochondrial membrane.; Similarity: the predicted protein shows strong similarity to the rabbit Ca2+-dependent carrier and to other similar mammalian proteins like human Aralar.; Similarity: these proteins are characterized by the presence, in the N-terminal, of EF-hands that bind calcium and cause conformational changes.; Title: strong similarity to Ca-dependent solute carrier - Oryctolagus cuniculus; See PMID 9238007; See PMID 9722566; uncharacterized protein 1411879 4988205 An15g06040 Aspergillus niger uncharacterized protein XP_059602592.1 1409675 R 5061 CDS An15g06050 4988206 join(1412558..1412717,1412753..1412986,1413042..1413577) III 1 NT_166530.1 Complex: UME3 of S. cerevisiae is a component of RNA polymerase II holoenzyme, involved in RNA pol II carboxy-terminal domain phosphorylation.; Function: activity of the kinase (SSN3)/cyclin (SSN8) pair is required, along with SSN6 & TUP1, for transcriptional repression of specific genes.; Remark: UME3 of S. cerevisiae is also known as GIG3,NUT9, SRB11, SSN8 or YNL025C.; Similarity: UME3 of S. cerevisiae and the predicted ORF show strong similarity to human cyclin C and to H. sapiens cyclin H/S. cerevisiae ccl1, which are decribed to be a companion of cdk7, the cyclin-dependent kinase involved in the phosphorylation of the largest subunit of the RNA polymerase II; both are part of a subcomplex of TFIIH, the transcription initation factor TFIIK.; Title: strong similarity to cyclin homolog Ume3 -Saccharomyces cerevisiae; nucleus; See PMID 7732022; See PMID 8524287; See PMID 9303311; See PMID 9488431; See PMID 9520600; uncharacterized protein 1413577 4988206 An15g06050 Aspergillus niger uncharacterized protein XP_059602593.1 1412558 D 5061 CDS An15g06060 84593236 join(1414457..1414541,1414874..1415089,1415140..1415377,1415426..1415536,1415620..1415689,1415773..1415946,1416169..1416294,1416337..1416402) III 1 NT_166530.1 hypothetical protein 1416402 84593236 An15g06060 Aspergillus niger hypothetical protein XP_059602594.1 1414457 D 5061 CDS An15g06070 84593237 complement(join(1417005..1417053,1417101..1417255)) III 1 NT_166530.1 Title: questionable ORF; uncharacterized protein 1417255 84593237 An15g06070 Aspergillus niger uncharacterized protein XP_059602595.1 1417005 R 5061 CDS An15g06080 4988209 join(1418498..1418788,1418903..1419217) III 1 NT_166530.1 Title: similarity to hypothetical protein SPAC22H10.02 - Schizosaccharomyces pombe; uncharacterized protein 1419217 4988209 An15g06080 Aspergillus niger uncharacterized protein XP_001397137.1 1418498 D 5061 CDS An15g06090 84593238 complement(join(1420053..1420202,1420280..1420381,1420462..1420530,1420775..1420885,1421021..1421092)) III 1 NT_166530.1 hypothetical protein 1421092 84593238 An15g06090 Aspergillus niger hypothetical protein XP_059602596.1 1420053 R 5061 CDS An15g06100 4988211 join(1421582..1421705,1421767..1421879,1421985..1422095) III 1 NT_166530.1 Title: weak similarity to hypothetical protein B21O8.60 - Neurospora crassa; uncharacterized protein 1422095 4988211 An15g06100 Aspergillus niger uncharacterized protein XP_001397139.1 1421582 D 5061 CDS An15g06110 4988212 complement(1422603..1423385) III 1 NT_166530.1 Function: syntaxins are involved in intracellular vesicle trafficking.; Similarity: the predicted protein shows much stronger similarity to syntaxin 8 related protein of Neurospora crassa, a hypothetical protein.; Title: weak similarity to syntaxin 6 STX6 - Rattus norvegicus; See PMID 8663448; uncharacterized protein 1423385 4988212 An15g06110 Aspergillus niger uncharacterized protein XP_001397140.1 1422603 R 5061 CDS An15g06120 4988213 join(1424041..1424577,1424635..1425435) III 1 NT_166530.1 Similarity: mouse TRAF5 is member of the TNF receptor-associated factors family, implicated in signal transduction especially in lymphocytes.; Similarity: the predicted protein shares with TRAF5 many structural and functional domains, implicating a conservation of the signal transduction properties,although in different physiological contexts.; Title: similarity to TRAF5 - Mus musculus; See PMID 9990039; See PMID 10202013; See PMID 10449775; See PMID 10523862; See PMID 11046039; uncharacterized protein 1425435 4988213 An15g06120 Aspergillus niger uncharacterized protein XP_001397141.1 1424041 D 5061 CDS An15g06140 4988215 complement(join(1427006..1428296,1428405..1429052,1429124..1429282,1429343..1429490,1429546..1429642)) III 1 NT_166530.1 Function: hyphal fusion between N. crassa strains that are of alternative het-C specificity results in vegetative heterokaryons that are aconidial and which show growth inhibition and hyphal compartmentation and death.; Function: in Neurospora crassa, 11 het loci have been identified that affect the viability of vegetative heterokaryons; the het-C locus has at least three mutually incompatible alleles, termed het-c(OR), het-c(PA), and het-c(GR).; Function: in filamentous fungi, nonself recognition during vegetative growth is believed to be mediated by genetic differences at heterokaryon incompatibility (het) loci.; Title: strong similarity to heterokaryon incompatibility protein HET-C - Neurospora crassa; See PMID 8001163; See PMID 8088519; See PMID 8844148; See PMID 9258675; See PMID 124288; uncharacterized protein 1429642 4988215 An15g06140 Aspergillus niger uncharacterized protein XP_059602597.1 1427006 R 5061 CDS An15g06150 4988216 1431239..1432198 III 1 NT_166530.1 Title: strong similarity to hypothetical protein EAA64210.1 - Aspergillus nidulans; uncharacterized protein 1432198 4988216 An15g06150 Aspergillus niger uncharacterized protein XP_001397143.1 1431239 D 5061 CDS An15g06160 4988217 complement(join(1432466..1432705,1432755..1433462,1433697..1433735)) III 1 NT_166530.1 Similarity: the predicted ORF shows similarity to different known or hypothetical methyltransferases with different specificity.; Title: similarity to gamma-tocopherol methyltransferase gamma-TMT from patent WO9904622-A1 -Synechocystis sp.; uncharacterized protein 1433735 4988217 An15g06160 Aspergillus niger uncharacterized protein XP_001397144.1 1432466 R 5061 CDS An15g06170 84593239 complement(join(1434164..1434326,1434418..1434480,1434573..1434586,1434730..1434879)) III 1 NT_166530.1 hypothetical protein 1434879 84593239 An15g06170 Aspergillus niger hypothetical protein XP_059602598.1 1434164 R 5061 CDS An15g06180 4988219 complement(join(1436033..1437803,1437859..1438388,1438443..1439261)) III 1 NT_166530.1 Remark: the ORF is also called SPAC22H10. 03c.; Title: strong similarity to hypothetical protein ranbp7p - Schizosaccharomyces pombe; uncharacterized protein 1439261 4988219 An15g06180 Aspergillus niger uncharacterized protein XP_001397146.1 1436033 R 5061 CDS An15g06190 84593240 join(1444030..1444369,1444430..1444689,1444756..1444863) III 1 NT_166530.1 Complex: the 'Spindle Checkpoint Complex' is composed of Mad1, Mad2 and Mad3. It interacts with Cdc20.; Function: the S. cerevisiae Mad2 protein is involved in the feedback control that prevents cells with incompletely assembled spindles from leaving mitosis.; Remark: alternate name for S. cerevisiae Mad2: YJL030W.; Similarity: the ORF DNA sequence shows also similarity to the E. nidulans EST v7h04a1. f1.; Title: similarity to spindle checkpoint protein Mad2 - Saccharomyces cerevisiae; nucleus; See PMID 10366450; See PMID 10837255; uncharacterized protein 1444863 84593240 An15g06190 Aspergillus niger uncharacterized protein XP_059602599.1 1444030 D 5061 CDS An15g06200 4988221 complement(join(1447061..1447234,1447387..1447504,1447563..1447749,1447792..1448689,1448733..1448765,1448800..1448992,1449047..1449714)) III 1 NT_166530.1 Title: similarity to transcriptional regulator molecule HTRM clone 693452 from patent WO9957144-A2 - Homo sapiens; uncharacterized protein 1449714 4988221 An15g06200 Aspergillus niger uncharacterized protein XP_059602600.1 1447061 R 5061 CDS An15g06210 4988222 join(1450927..1451063,1451105..1452509) III 1 NT_166530.1 Similarity: the ORF encoded protein closer related to hypothetical protein YGR111w from S. cerevisiae.; Title: weak similarity to alpha-2 subunit of propyl-4-hydrolase from patent WO9738121-A1 - Mus sp.; uncharacterized protein 1452509 4988222 An15g06210 Aspergillus niger uncharacterized protein XP_001397149.3 1450927 D 5061 CDS An15g06220 4988223 complement(join(1452667..1452956,1453027..1453766,1453832..1453950)) III 1 NT_166530.1 Title: weak similarity to hypothetical replicase ORF-I - Garlic virus C; uncharacterized protein 1453950 4988223 An15g06220 Aspergillus niger uncharacterized protein XP_059602601.1 1452667 R 5061 CDS An15g06230 4988224 complement(join(1454571..1454951,1455002..1455321,1455373..1456055,1456207..1456298)) III 1 NT_166530.1 Function: the S. cerevisiae Anp1 protein involved in the organization of the secretory pathway. It required to maintain a functional Golgi-apparatus.; Golgi; Remark: alternate names for S. cerevisiae Anp1: Gem3, Mnn8 or YEL036C.; Similarity: the S. cerevisiae Anp1 belongs to the Anp1 / Mmn9 / Van1 family.; Title: strong similarity to aminonitrophenyl propanediol resistance protein Anp1 - Saccharomyces cerevisiae; See PMID 7957057; See PMID 9434768; See PMID 10635561; uncharacterized protein 1456298 4988224 An15g06230 Aspergillus niger uncharacterized protein XP_001397151.1 1454571 R 5061 CDS An15g06240 4988225 complement(join(1456989..1457390,1457460..1458095)) III 1 NT_166530.1 Catalytic activity: chlorophyllide A + NADP(+) <=> protochlorophyllide + NADPH.; Function: the PorB protein from Hordeum vulgare is involved in the phototransformation of protochlorophyllide (pchlide) to chlorophyllide (chlide).; Similarity: the ORF DNA sequence shows strong similarity to the Aspergillus niger EST an_2781. The ORF encoded protein is also similar to the protein from patent WO9423043-A, which is functionally not clearly enough described.; Title: similarity to NADPH-protochlorophyllide oxidoreductase PorB - Hordeum vulgare; See PMID 7724548; uncharacterized protein 1458095 4988225 An15g06240 Aspergillus niger uncharacterized protein XP_001397152.1 1456989 R 5061 CDS An15g06250 4988226 complement(join(1461334..1461461,1461547..1462032,1462097..1462183,1462265..1462513,1462604..1462637,1462817..1462903)) III 1 NT_166530.1 Catalytic activity: (R,R)-butane-2,3-diol + NAD(+) <=> (R)-acetoin + NADH.; Title: strong similarity to 2,3-butanediol dehydrogenase ADH - Pseudomonas putida; See PMID 7813883; uncharacterized protein 1462903 4988226 An15g06250 Aspergillus niger uncharacterized protein XP_001397153.1 1461334 R 5061 CDS An15g06260 4988227 complement(1463336..1464682) III 1 NT_166530.1 Function: the S. cerevisiae Arc1 protein binds specifically G4 quadruplex nucleic acid structures (these are four-stranded right-handed helices, stabilized by guanine base quartets). It binds to tRNA and functions as a cofactor for the methionyl- and glutamyl-tRNA synthetases.; Remark: alternate names for S. cerevisiae Arc1: G4P1 or YGL105W.; Title: strong similarity to GU4 nucleic-binding protein 1 Arc1 - Saccharomyces cerevisiae; See PMID 8895587; See PMID 9659920; See PMID 11069915; uncharacterized protein 1464682 4988227 An15g06260 Aspergillus niger uncharacterized protein XP_001397154.1 1463336 R 5061 CDS An15g06270 4988228 join(1465815..1465982,1466042..1466956) III 1 NT_166530.1 Similarity: the ORF encoded protein exclusively shows strong similarity to the hypothetical protein B11B22. 120 from Neurospora crassa.; Title: similarity to potassium-dependent sodium-calcium exchanger NCKX1 - Gallus gallus; See PMID 10662833; See PMID 11023899; uncharacterized protein 1466956 4988228 An15g06270 Aspergillus niger uncharacterized protein XP_001397155.1 1465815 D 5061 CDS An15g06280 4988229 complement(join(1467346..1467476,1467535..1468295,1468353..>1468606)) III 1 NT_166530.1 Function: A. niger Aspergillopepsin I catalyzes the hydrolysis of proteins with a broad specificity. It generally favors hydrophobic residues in P1 and P1', but also accepts Lys in P1, which leads to activation of trypsinogen. It does not clot milk.; Remark: N-terminally truncated ORF due to the end of contig.; Remark: alternate names for the A. niger Aspergillopepsin I protease: Awamorin, Aspergillopepsin A,Proteinase B, Proctase B, PepA or Aspergillopeptidase A.; Title: strong similarity to aspartic proteinase aspergillopepsin I pepA - Aspergillus niger [truncated ORF]; extracellular/secretion proteins; See PMID 7787314; See PMID 1508158; uncharacterized protein 1468606 4988229 An15g06280 Aspergillus niger uncharacterized protein XP_001397156.3 1467346 R 5061 CDS An15g06290 4988230 complement(join(1470727..1471673,1471738..1471822)) III 1 NT_166530.1 Function: the B. subtilis MinD ATPase is required for the correct placement of the division site. The cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. It rapidly oscillates between the poles of the cell to destabilize FTSZ filaments that have formed before they mature into polar Z rings.; Similarity: the ORF encoded protein shows strongest similarity to the protein of unknown function Nbp35 from S. cerevisiae. It also shows strong similarity to the protein sequence HTRM clone 1870914 from patent WO9957144-A2,which function is not clearly enough described.; Title: similarity to cell division inhibitor ATPase minD - Bacillus subtilis; See PMID 10411726; uncharacterized protein 1471822 4988230 An15g06290 Aspergillus niger uncharacterized protein XP_001397157.1 1470727 R 5061 CDS An15g06300 84593241 join(1472663..1472719,1472815..1472976,1473065..1473112) III 1 NT_166530.1 hypothetical protein 1473112 84593241 An15g06300 Aspergillus niger hypothetical protein XP_059602602.1 1472663 D 5061 CDS An15g06310 4988232 join(1473899..1474079,1474216..1476160,1476215..1476784,1476853..1476943,1477006..1477070,1477318..1477340,1477400..1477758) III 1 NT_166530.1 Catalytic activity: S-adenosyl-L-methionine + phosphatidylethanolamine <=> S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine.; Pathway: S. pombe Cho2 catalyzes the first step in phosphatidylethanolamine methylation pathway.; Title: strong similarity to phosphatidylethanolamine methyltransferase cho2p - Schizosaccharomyces pombe; See PMID 10799484; See PMID 1655700; uncharacterized protein 1477758 4988232 An15g06310 Aspergillus niger uncharacterized protein XP_059602603.1 1473899 D 5061 CDS An15g06320 4988233 join(1478830..1478968,1479027..1479862) III 1 NT_166530.1 Remark: the human protein hRrp41p was expressed in yeast and shown to suppress the lethality of genetic depletion of yeast Rrp41p.; Similarity: the ORF DNA sequence very strong similar to the Aspergillus niger EST an_2945.; Title: similarity to exosome component Rrp41 - Homo sapiens; See PMID 11017189; See PMID 11110791; uncharacterized protein 1479862 4988233 An15g06320 Aspergillus niger uncharacterized protein XP_001397160.1 1478830 D 5061 CDS An15g06330 84593242 join(1480310..1480381,1480440..1480841,1481197..1481291,1481327..1481357,1481408..1481431,1481464..1481483,1481562..1481640) III 1 NT_166530.1 Title: weak similarity to SFV4 non-structural polyprotein from patent WO9210578-A - Semliki forest virus; uncharacterized protein 1481640 84593242 An15g06330 Aspergillus niger uncharacterized protein XP_059602604.1 1480310 D 5061 CDS An15g06340 84593243 complement(join(1482698..1482829,1482873..1482947,1483234..1483287,1483357..1483569,1483671..1483808)) III 1 NT_166530.1 Title: weak similarity to myosin-IA - Acanthamoeba castellanii; uncharacterized protein 1483808 84593243 An15g06340 Aspergillus niger uncharacterized protein XP_059602605.1 1482698 R 5061 CDS An15g06350 4988236 1484194..1486242 III 1 NT_166530.1 Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: weak similarity to splicing coactivator subunit SRm300 - Homo sapiens; uncharacterized protein 1486242 4988236 An15g06350 Aspergillus niger uncharacterized protein XP_001397163.1 1484194 D 5061 CDS An15g06360 4988237 complement(join(1487181..1487191,1487258..1488519,1488589..1488758,1488815..1489186)) III 1 NT_166530.1 Remark: In Drosophila, glutamyl-prolyl-tRNA synthetase Aats-glupro is a multifunctional synthetase encoded by a unique gene and composed of three domains: the amino- and carboxy-terminal domains catalyze the aminoacylation of glutamic acid and proline tRNA species,respectively, and the central domain is made of 75 amino acids repeated six times amongst which 46 are highly conserved and constitute the repeated motifs.; Similarity: the predited ORF is about 1000 amino acids shorter at the N-terminus than D. melanogaster Aats-glupro.; Title: similarity to multifunctional glutamine-proline--tRNA ligase Aats-glupro - Drosophila melanogaster; See PMID 1756734; See PMID 9063462; uncharacterized protein 1489186 4988237 An15g06360 Aspergillus niger uncharacterized protein XP_001397164.1 1487181 R 5061 CDS An15g06370 4988238 join(1489439..1489481,1489523..1489594,1489651..1489736,1489796..1489900,1489969..1491003,1491064..1491447) III 1 NT_166530.1 Function: TCP1 is proposed to be required for normal development and function of actin and microtubules either through direct or indirect interaction with the major cytoskeletal components.; Localization: TCP1 from S. cerevisiae was localized to the cytoplasm and the cell cortex.; Title: strong similarity to T-complex-type molecular chaperone Tcp1 - Saccharomyces cerevisiae; See PMID 1901944; See PMID 7865875; uncharacterized protein 1491447 4988238 An15g06370 Aspergillus niger uncharacterized protein XP_059602606.1 1489439 D 5061 CDS An15g06380 4988239 complement(join(1491946..1493327,1493384..1493503,1493547..1494189)) III 1 NT_166530.1 Function: l(2)dtl encodes a signal transduction protein involved in cell cycle control.; Induction: induction of l(2)dtl is by heat shock.; Title: similarity to lethal(2)denticleless l(2)dtl -Drosophila melanogaster; See PMID 8666267; uncharacterized protein 1494189 4988239 An15g06380 Aspergillus niger uncharacterized protein XP_059602607.1 1491946 R 5061 CDS An15g06390 4988240 join(1494600..1495082,1495143..1499570,1499629..1500186) III 1 NT_166530.1 Function: RRP5 is required for formation of both 18S and 5. 8S rRNA in yeast.; Localization: Nucleolus; Title: strong similarity to ribosomal RNA processing protein Rrp5 - Saccharomyces cerevisiae; nucleus; See PMID 8896463; uncharacterized protein 1500186 4988240 An15g06390 Aspergillus niger uncharacterized protein XP_001397167.1 1494600 D 5061 CDS An15g06400 4988241 complement(join(1500398..1501599,1501691..1501700)) III 1 NT_166530.1 Title: similarity to hypothetical protein CAD70839.1 - Neurospora crassa; uncharacterized protein 1501700 4988241 An15g06400 Aspergillus niger uncharacterized protein XP_059602608.1 1500398 R 5061 CDS An15g06410 4988242 join(1503337..1503737,1503826..1504948) III 1 NT_166530.1 Title: similarity to hypothetical membrane protein YDL237w - Saccharomyces cerevisiae; uncharacterized protein 1504948 4988242 An15g06410 Aspergillus niger uncharacterized protein XP_001397169.1 1503337 D 5061 CDS An15g06420 4988243 complement(1505584..1506654) III 1 NT_166530.1 Title: weak similarity to urease accessory gene ureD - Bacillus sp.; uncharacterized protein 1506654 4988243 An15g06420 Aspergillus niger uncharacterized protein XP_001397170.1 1505584 R 5061 CDS An15g06430 4988244 join(1507862..1508363,1508430..1511581) III 1 NT_166530.1 Complex: XSA1 is a subunit of the cohesin complex which plays an essential role in sister chromatid cohesion in Xenopus laevis cell-free extracts.; Similarity: XSA1 belongs to the SA family of mammalian proteins and exhibit similarity to Scc3p, a recently identified component of yeast cohesin.; Title: strong similarity to cohesin subunit XSA1 -Xenopus laevis; See PMID 10931856; uncharacterized protein 1511581 4988244 An15g06430 Aspergillus niger uncharacterized protein XP_001397171.1 1507862 D 5061 CDS An15g06440 4988245 complement(join(<1513212..1513877,1513937..1514446,1514736..1514969)) III 1 NT_166530.1 Function: Srp1p (importin alpha) functions as the nuclear localization signal (NLS) receptor in S. cerevisiae.; Function: Srp1p of S. cerevisiae has also a role in regulation of protein degradation separate from its well-established role as the NLS receptor.; Function: Srp1p of S. cerevisiae is involved in nuclear import, nuclear structure, chromosome segregation,and cell cycle.; Remark: C-terminally truncated ORF due to contig border.; Title: strong similarity to karyopherin alpha Srp1 -Saccharomyces cerevisiae [truncated ORF]; See PMID 7644471; See PMID 10394916; See PMID 10913188; uncharacterized protein 1514969 4988245 An15g06440 Aspergillus niger uncharacterized protein XP_001397172.3 1513212 R 5061 CDS An15g06450 4988246 join(1515673..1515942,1516000..1516909,1517107..1517338,1517425..1517716) III 1 NT_166530.1 Title: similarity to hypothetical protein SPAC26H5.06 - Schizosaccharomyces pombe; uncharacterized protein 1517716 4988246 An15g06450 Aspergillus niger uncharacterized protein XP_059602609.1 1515673 D 5061 CDS An15g06460 4988247 complement(join(1518291..1519526,1519585..1519587)) III 1 NT_166530.1 Title: strong similarity to hypothetical protein CAD21104.1 - Neurospora crassa; uncharacterized protein 1519587 4988247 An15g06460 Aspergillus niger uncharacterized protein XP_059602610.1 1518291 R 5061 CDS An15g06470 4988248 join(1520452..1520523,1520598..1521028,1521086..1521371) III 1 NT_166530.1 Function: the signal-sequence receptor (SSR) has been shown to be a component of the environment which nascent polypeptides meet on passage through the endoplasmic reticulum (ER) membrane.; Remark: shows similarity to other eukaryotic signal sequence receptor alpha chains, but in most cases the C-terminal part differs.; Title: similarity to signal sequence receptor alpha chain - Canis lupus; endoplasmatic reticulum; uncharacterized protein 1521371 4988248 An15g06470 Aspergillus niger uncharacterized protein XP_001397175.1 1520452 D 5061 CDS An15g06480 4988249 complement(join(1521730..1522487,1522577..1522679)) III 1 NT_166530.1 Remark: the matching TREMBL entry SCCDC31_2 does not contain the sequence of the S. cerevisiae CDC31 but that of YOR258w.; Similarity: shows also strong similarity to hypothetical protein YOR258w of S. cerevisiae.; Title: strong similarity to hypothetical protein SPCC18.09c - Schizosaccharomyces pombe; uncharacterized protein 1522679 4988249 An15g06480 Aspergillus niger uncharacterized protein XP_001397176.1 1521730 R 5061 CDS An15g06490 4988250 join(1522989..1523231,1523318..1526852,1526940..1527208) III 1 NT_166530.1 Function: might be involved in mRNA splicing.; Similarity: shows strong similarity to several hypothetical ATP-dependent helicases.; Title: strong similarity to hypothetical ATP-dependent RNA helicase YLR419w - Saccharomyces cerevisiae; See PMID 11230534; uncharacterized protein 1527208 4988250 An15g06490 Aspergillus niger uncharacterized protein XP_001397177.1 1522989 D 5061 CDS An15g06500 4988251 complement(join(1528243..1528506,1528560..1529099,1529161..1530141)) III 1 NT_166530.1 Similarity: shows similarity to several B-type cyclins of different organisms, but onlythe nimE of A. nidulans shows an almost overall similarity.; Title: strong similarity to cyclin B nimE -Aspergillus nidulans; See PMID 9647650; See PMID 9802893; See PMID 10564263; See PMID 10601021; See PMID 11102358; uncharacterized protein 1530141 4988251 An15g06500 Aspergillus niger uncharacterized protein XP_059602611.1 1528243 R 5061 CDS An15g06510 84593244 complement(join(1531285..1531465,1531528..1531604)) III 1 NT_166530.1 hypothetical protein 1531604 84593244 An15g06510 Aspergillus niger hypothetical protein XP_059602612.1 1531285 R 5061 CDS An15g06520 84593245 complement(join(1532505..1532575,1532667..1532944,1533130..1533332)) III 1 NT_166530.1 hypothetical protein 1533332 84593245 An15g06520 Aspergillus niger hypothetical protein XP_059602613.1 1532505 R 5061 CDS An15g06530 84593246 complement(join(1534061..1534480,1534687..1535076)) III 1 NT_166530.1 Remark: blastp matches due to glycine-richness of protein.; hypothetical protein 1535076 84593246 An15g06530 Aspergillus niger hypothetical protein XP_059602614.1 1534061 R 5061 CDS An15g06540 4988255 join(1535123..1535899,1535978..1537264) III 1 NT_166530.1 Remark: a splice site was detected upstream of the START codon.; Title: similarity to hypothetical protein CAC28648.1 - Neurospora crassa; uncharacterized protein 1537264 4988255 An15g06540 Aspergillus niger uncharacterized protein XP_001397182.1 1535123 D 5061 CDS An15g06550 4988256 join(1538501..1540279,1540747..1540781,1540826..1540863,1540944..1540948,1541071..1541244) III 1 NT_166530.1 Title: weak similarity to 47 kD subunit of DNA-directed RNA polymerase III Rpc53 - Saccharomyces cerevisiae; uncharacterized protein 1541244 4988256 An15g06550 Aspergillus niger uncharacterized protein XP_001397183.3 1538501 D 5061 CDS An15g06560 4988257 join(1542063..1542417,1542719..1542772,1542952..1543070) III 1 NT_166530.1 Similarity: shows only similarity against the N-terminal part of the A. thaliana ORF.; Title: weak similarity to hypothetical proline-rich protein T20D16.24 - Arabidopsis thaliana; uncharacterized protein 1543070 4988257 An15g06560 Aspergillus niger uncharacterized protein XP_059602615.1 1542063 D 5061 CDS An15g06570 84593247 join(1543255..1543438,1543680..1544041) III 1 NT_166530.1 hypothetical protein 1544041 84593247 An15g06570 Aspergillus niger hypothetical protein XP_059602616.1 1543255 D 5061 CDS An15g06580 4988259 complement(join(1544253..1544659,1544789..1544888,1544944..1545120)) III 1 NT_166530.1 Catalytic activity: uracil phosphoribosyltransferase catalyzes the conversion of UMP + pyrophosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.; Gene-ID: furA; Pathway: pyrimidine salvage pathway.; Remark: the matching sequence of furA from A. niger (EMBL: AAK08633) was identified by an BLASTX search.; uracil phosphoribosyltransferase furA-Aspergillus niger 1545120 furA 4988259 furA Aspergillus niger uracil phosphoribosyltransferase furA-Aspergillus niger XP_001397186.1 1544253 R 5061 CDS An15g06590 84593248 complement(1545891..1546160) III 1 NT_166530.1 Title: weak similarity to hypothetical mitochondrial H+-transporting ATP synthase protein 6 homolog MURF4 -Leishmania tarentolae; uncharacterized protein 1546160 84593248 An15g06590 Aspergillus niger uncharacterized protein XP_059602617.1 1545891 R 5061 CDS An15g06600 4988261 complement(join(1546360..1546501,1546559..1547553,1547609..1548765,1548918..1549053)) III 1 NT_166530.1 Function: AmdA (A. nidulans) fusions with the GAL4 DNA binding domain in S. cerevisiae revealed its ability to activate transcription.; Remark: amdA of A. nidulans has only two introns.; Title: strong similarity to zinc-finger transcription factor amdA - Aspergillus nidulans; nucleus; See PMID 7596297; See PMID 9126617; uncharacterized protein 1549053 4988261 An15g06600 Aspergillus niger uncharacterized protein XP_059602618.1 1546360 R 5061 CDS An15g06610 84593249 join(1549449..1549569,1549639..1550111) III 1 NT_166530.1 hypothetical protein 1550111 84593249 An15g06610 Aspergillus niger hypothetical protein XP_059602619.1 1549449 D 5061 CDS An15g06620 84593250 join(1551801..1552145,1552208..1552600) III 1 NT_166530.1 Similarity: shows matches to proline-rich proteins.; hypothetical protein 1552600 84593250 An15g06620 Aspergillus niger hypothetical protein XP_059602620.1 1551801 D 5061 CDS An15g06630 84593251 join(1553804..1553942,1554082..1554178,1554443..1554843,1554961..1555009,1555158..1555217,1555290..1555493,1555604..1555670) III 1 NT_166530.1 Similarity: aminoacids 120 to 215 show similarity to AL0 protein of Indian cassava mosaic virus.; hypothetical protein 1555670 84593251 An15g06630 Aspergillus niger hypothetical protein XP_059602621.1 1553804 D 5061 CDS An15g06640 84593252 join(1555713..1555920,1556309..1556433) III 1 NT_166530.1 hypothetical protein 1556433 84593252 An15g06640 Aspergillus niger hypothetical protein XP_059602622.1 1555713 D 5061 CDS An15g06650 4988266 join(1563113..1563500,1563546..1566304,1566369..1566585,1566656..1566923,1567188..1567644) III 1 NT_166530.1 Similarity: N-terminal half differs from all homologs, except the N-terminal SH3 domain.; Similarity: shows similarity to several guanine-nucleotide exchange proteins.; Title: similarity to guanine-nucleotide exchange protein Cdc25 - Saccharomyces cerevisiae; See PMID 10747046; See PMID 1667084; See PMID 1668647; uncharacterized protein 1567644 4988266 An15g06650 Aspergillus niger uncharacterized protein XP_059602623.1 1563113 D 5061 CDS An15g06660 4988267 complement(join(1568078..1568214,1568531..1569448,1569517..1569541)) III 1 NT_166530.1 Complex: the COP9 signalosome has eight core subunits that are highly conserved between plants and animals; some of the subunits in Arabidopsis are found in forms that are independent of the complex.; Function: mouse JAB1/CSN5 has been implicated in numerous signaling pathways including those that regulate light signaling in plants, larval development in Drosophila, and integrin signaling, cell cycle control, and steroid hormone signaling in a number of systems.; Function: the COP9 signalosome may have both an evolutionary and a physical relationship with both the regulatory lid of the proteasome and eIF3.; Function: the Constitutive Photomorphogenic9 (COP9) complex is a nuclear localized, multisubunit protein complex essential for repression of light-mediated development in Arabidopsis.; Function: the mouse Jun activating binding protein (JAB1) specifically stabilizes complexes of c-Jun or JunD with AP-1 sites, increasing the specificity of target gene activation by AP-1 proteins; JAB1 is also known as COP9 signalosome subunit 5 (CSN5), which is a component of the COP9 signalosome regulatory complex (CSN).; Similarity: shows also strong similarity to Jun coactivator Jab1 of M. musculus and related proteins.; Title: strong similarity to constitutive photomorphogenic COP9 complex chain AJH2 - Arabidopsis thaliana; nucleus; See PMID 10363642; See PMID 11019806; See PMID 11258719; uncharacterized protein 1569541 4988267 An15g06660 Aspergillus niger uncharacterized protein XP_001397194.3 1568078 R 5061 CDS An15g06670 4988268 join(1570255..1570371,1570423..1570475,1570532..1570746,1570797..1572742) III 1 NT_166530.1 Expression: human PRC1 protein levels are high during S and G2/M and drop dramatically after cells exit mitosis and enter G1.; Function: human PRC1 is a good substrate for several CDKs in vitro and is phosphorylated in vivo at sites that are phosphorylated by CDK in vitro, strongly suggesting that PRC1 is an in vivo CDK substrate.; Function: human PRC1 is involved in cytokinesis.; Localization: PRC1 is a nuclear protein in interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis.; Similarity: shows also similarity to anaphase spindle elongation protein ASE1 of S. cerevisiae.; Title: strong similarity to protein regulating cytokinesis PRC1 - Homo sapiens; uncharacterized protein 1572742 4988268 An15g06670 Aspergillus niger uncharacterized protein XP_001397195.1 1570255 D 5061 CDS An15g06680 4988269 complement(join(1573694..1574288,1574357..1574523,1574582..1574839,1574893..1575306,1575367..1575404,1575474..1575546,1575625..1575915)) III 1 NT_166530.1 Catalytic activity: glutamate--tRNA ligases catalyze the conversion of ATP + L-glutamate + tRNA(Glu) = AMP + pyrophosphate + L-glutamyl-tRNA(Glu).; Similarity: shows strong similarity to several eukaryotic mitochondrial and prokaryotic glutamate--tRNA ligases.; Title: strong similarity to mitochondrial glutamate--tRNA ligase Mse1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 7607232; uncharacterized protein 1575915 4988269 An15g06680 Aspergillus niger uncharacterized protein XP_001397196.1 1573694 R 5061 CDS An15g06690 4988270 join(1576331..1576334,1576410..1576436,1576529..1576587,1576652..1577096,1577159..1577336,1577393..1577916,1578207..1578355) III 1 NT_166530.1 Function: human HIRIP4 has been shown to be a positive cochaperones of hsc70.; Function: the chaperone function of Hsp70 proteins in these events is regulated by members of the DnaJ-like protein family, which occurs through direct interaction of different Hsp70 and DnaJ-like protein pairs that appear to be specifically adapted to each other.; Function: the folding of proteins and the assembly of protein complexes within subcompartments of the eukaryotic cell is catalysed by different members of the Hsp70 protein family.; Similarity: shows similarity to several other eukaryotic dnaJ related proteins.; Title: strong similarity to dnaJ related protein HIRIP4 - Homo sapiens; See PMID 8016869; See PMID 10816573; uncharacterized protein 1578355 4988270 An15g06690 Aspergillus niger uncharacterized protein XP_001397197.3 1576331 D 5061 CDS An15g06700 4988271 join(1580039..1580482,1580548..1580702,1580758..1581973) III 1 NT_166530.1 Catalytic activity: dihydroxy-acid dehydratase catalyzes the conversion of 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O.; Pathway: fourth step in valine and isoleucine biosynthesis.; Title: strong similarity to dihydroxy-acid dehydratase ilvD - Bacillus subtilis; See PMID 1400210; uncharacterized protein 1581973 4988271 An15g06700 Aspergillus niger uncharacterized protein XP_001397198.3 1580039 D 5061 CDS An15g06710 4988272 1584512..1585006 III 1 NT_166530.1 hypothetical protein 1585006 4988272 An15g06710 Aspergillus niger hypothetical protein XP_001397199.1 1584512 D 5061 CDS An15g06720 4988273 complement(join(1585976..1586426,1586489..1586565)) III 1 NT_166530.1 Title: strong similarity to hypothetical conserved protein PA5185 - Pseudomonas aeruginosa; uncharacterized protein 1586565 4988273 An15g06720 Aspergillus niger uncharacterized protein XP_001397200.1 1585976 R 5061 CDS An15g06730 4988274 join(1589601..1589843,1589910..1590430,1590533..1591223) III 1 NT_166530.1 Similarity: patentmatch against protein AC A46560_1 Trembl.; Title: strong similarity to sequence 3 from patent WO9526406 - Eremothecium gossypii; uncharacterized protein 1591223 4988274 An15g06730 Aspergillus niger uncharacterized protein XP_059602624.1 1589601 D 5061 CDS An15g06740 4988275 complement(join(1591986..1592094,1592165..1592411,1592782..1592821,1592874..1592892,1593065..1593189)) III 1 NT_166530.1 Alternative name: Rp49; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L32 - Drosophila subobscura; cytoplasm; See PMID 6087289; 60S ribosomal eL32 domain-containing protein 1593189 4988275 An15g06740 Aspergillus niger 60S ribosomal eL32 domain-containing protein XP_001397202.3 1591986 R 5061 CDS An15g06750 4988276 join(1593532..1593641,1593691..1594860,1594915..1597045) III 1 NT_166530.1 Remark: ankyrins attach integral membrane proteins to cytoskeletal elements; they bind to Na-K Atpase and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin.; Remark: the H. sapiens brain variant ank2 gene might be alternative spliced producing two variants.; Title: similarity to ankyrin Ank2 - Homo sapiens; See PMID 8253844; See PMID 8557748; uncharacterized protein 1597045 4988276 An15g06750 Aspergillus niger uncharacterized protein XP_059602625.1 1593532 D 5061 CDS An15g06760 4988277 complement(join(1597217..1597710,1597783..1598060,1598132..1598325,1598386..1598411,1598497..1598533)) III 1 NT_166530.1 Title: similarity to D-oliose 4-ketoreductase mtmU -Streptomyces argillaceus; See PMID 8654997; See PMID 9150235; See PMID 10102355; uncharacterized protein 1598533 4988277 An15g06760 Aspergillus niger uncharacterized protein XP_001397204.1 1597217 R 5061 CDS An15g06770 4988278 complement(join(1599049..1599602,1599666..1599885)) III 1 NT_166530.1 Title: weak similarity to myosin heavy chain II -Acanthamoeba castellanii; See PMID 3040773; See PMID 3944121; uncharacterized protein 1599885 4988278 An15g06770 Aspergillus niger uncharacterized protein XP_001397205.1 1599049 R 5061 CDS An15g06780 4988279 complement(join(1601111..1601553,1601607..1601709,1601772..1602150,1602208..1602608,1602843..1602959)) III 1 NT_166530.1 Title: similarity to vesicular acetylcholine transporter VAChT - Homo sapiens; plasma membrane; See PMID 8071310; See PMID 9237624; See PMID 9782459; See PMID 7559575; uncharacterized protein 1602959 4988279 An15g06780 Aspergillus niger uncharacterized protein XP_001397206.3 1601111 R 5061 CDS An15g06790 4988280 complement(join(1604692..1605677,1605755..1606063,1606138..1606206,1606327..1606371,1606428..1606484,1606585..1606588)) III 1 NT_166530.1 Function: when overexpressed, Sce3 of S. pombe rescues all mutants of cdc11.; Localization: Sce3p of S. pombe is located predominantly in the cytoplasm.; Remark: in S. pombe, the cdc11 gene is required for the initiation of septum formation at the end of mitosis.; Remark: sce3 of S. pombe encodes a putative RNA-binding protein which shows homology to human eIF4B.; Similarity: the predicted A. niger protein shows strong similarity to the suppressor of the septation mutant cdc11 (Sce3) of S. pombe.; Title: strong similarity to suppressor of the septation mutant cdc11 sce3p - Schizosaccharomyces pombe; cytoplasm; See PMID 9254700; uncharacterized protein 1606588 4988280 An15g06790 Aspergillus niger uncharacterized protein XP_059602626.1 1604692 R 5061 CDS An15g06800 84593253 complement(join(1607555..1607674,1607730..1607801,1607952..1608014)) III 1 NT_166530.1 hypothetical protein 1608014 84593253 An15g06800 Aspergillus niger hypothetical protein XP_059602627.1 1607555 R 5061 CDS An15g06810 4988282 join(1609172..1609424,1609485..1609562,1609702..1610252) III 1 NT_166530.1 Catalytic activity: NADH + 2 ferricytochrome b5 = NAD(+) + 2 ferrocytochrome b5.; Remark: About one third of the S. cerevisiae Mcr1 precursor protein is inserted into the outer mitochondrium membrane whereas the remaining molecules pass through the outer membrane into the inner membrane, are cleaved by inner membrane protease 1, and are released into the intermembrane space.; Remark: The S. cerevisiae gene MCR1 encodes two mitochondrial isoforms of NADH-cytochrome b5 reductase.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to cytochrome-b5 reductase Mcr1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8001120; See PMID 9199337; uncharacterized protein 1610252 4988282 An15g06810 Aspergillus niger uncharacterized protein XP_001397209.1 1609172 D 5061 CDS An15g06820 4988283 join(1612871..1613722,1613792..1614945,1615018..1617424,1617467..1618508,1618641..1620545,1620756..1621447,1621497..1621597,1621648..1621708) III 1 NT_166530.1 Title: strong similarity to hypothetical protein SPAC3H5.09c - Schizosaccharomyces pombe; uncharacterized protein 1621708 4988283 An15g06820 Aspergillus niger uncharacterized protein XP_059602628.1 1612871 D 5061 CDS An15g06830 84593254 complement(join(1622784..1622841,1622882..1622988)) III 1 NT_166530.1 hypothetical protein 1622988 84593254 An15g06830 Aspergillus niger hypothetical protein XP_059602629.1 1622784 R 5061 CDS An15g06840 4988285 complement(join(1623962..1624327,1624410..1624649,1624785..1625426)) III 1 NT_166530.1 Title: strong similarity to hypothetical protein encoded by EAA61711.1 - Aspergillus nidulans; uncharacterized protein 1625426 4988285 An15g06840 Aspergillus niger uncharacterized protein XP_059602630.1 1623962 R 5061 CDS An15g06850 4988286 1625919..1626638 III 1 NT_166530.1 Title: strong similarity to hypothetical protein YBR261c - Saccharomyces cerevisiae; uncharacterized protein 1626638 4988286 An15g06850 Aspergillus niger uncharacterized protein XP_001397213.1 1625919 D 5061 CDS An15g06860 4988287 complement(join(1627343..1627597,1627648..1627997,1628054..1628079,1628129..1628190,1628243..1628361,1628424..1628601)) III 1 NT_166530.1 Title: similarity to hypothetical protein encoded by An06g02540 - Aspergillus niger; uncharacterized protein 1628601 4988287 An15g06860 Aspergillus niger uncharacterized protein XP_001397214.1 1627343 R 5061 CDS An15g06870 4988288 join(1629553..1629567,1629784..1630683) III 1 NT_166530.1 Title: strong similarity to hypothetical protein encoded by An15g02610 - Aspergillus niger; uncharacterized protein 1630683 4988288 An15g06870 Aspergillus niger uncharacterized protein XP_059602631.1 1629553 D 5061 CDS An15g06880 4988289 join(1631153..1631187,1631444..1631521,1631641..1631900,1632130..1633235,1633299..1637648) III 1 NT_166530.1 Title: similarity to hypothetical transcription factor subunit SPBC336.07 - Schizosaccharomyces pombe; uncharacterized protein 1637648 4988289 An15g06880 Aspergillus niger uncharacterized protein XP_059602632.1 1631153 D 5061 CDS An15g06890 84593255 complement(1638247..>1638552) III 1 NT_166530.1 Remark: ORF is N-terminal truncated due to contig end. Overlap with contig cmhx. 00.; hypothetical protein [truncated ORF] 1638552 84593255 An15g06890 Aspergillus niger hypothetical protein [truncated ORF] XP_059602633.1 1638247 R 5061 CDS An15g06900 4988291 complement(<1638653..1639040) III 1 NT_166530.1 Remark: ORF 3'truncated due to end of contig.; Remark: ubiquitin-conjugating enzymes (UBCs) selectively target proteins for proteasomal degradation by the covalent attachment of ubiquitin moieties.; Similarity: the M musculus NCUBE1, yeast UBC6 and chicken NCUBE1 constitute a distinct family of UBCs sharing a conserved noncanonical active site sequence and a C-terminal transmembrane domain.; Title: strong similarity to non-canonical ubiquitin conjugating enzyme 1 ncube1 - Mus musculus [truncated ORF]; endoplasmatic reticulum; See PMID 10708578; uncharacterized protein 1639040 4988291 An15g06900 Aspergillus niger uncharacterized protein XP_001397218.3 1638653 R 5061 CDS An15g06910 4988292 complement(join(1639353..1640680,1640744..1640942)) III 1 NT_166530.1 Remark: the predicted A. niger protein harbours a DHHC region PF01529 (aa 121-185) which is predicted to be a zink finger domain.; Title: similarity to educed expression in colorectal cancer protein rec - Homo sapiens; See PMID 10918388; uncharacterized protein 1640942 4988292 An15g06910 Aspergillus niger uncharacterized protein XP_059604728.1 1639353 R 5061 CDS An15g06920 4988293 complement(join(1641571..1641624,1641674..1642701,1642754..1643213)) III 1 NT_166530.1 Title: strong similarity to hypothetical membrane protein CAC18292.2 - Neurospora crassa; plasma membrane; uncharacterized protein 1643213 4988293 An15g06920 Aspergillus niger uncharacterized protein XP_001397220.1 1641571 R 5061 CDS An15g06925 4988294 complement(1644790..1645233) III 1 NT_166530.1 Title: weak similarity to hypothetical protein SPAC23A1.05 - Schizosaccharomyces pombe; uncharacterized protein 1645233 4988294 An15g06925 Aspergillus niger uncharacterized protein XP_001397221.1 1644790 R 5061 CDS An15g06930 84593256 complement(join(1645823..1645990,1646078..1646138,1646215..1646271,1646377..1646460,1646541..1646710)) III 1 NT_166530.1 hypothetical protein 1646710 84593256 An15g06930 Aspergillus niger hypothetical protein XP_059604729.1 1645823 R 5061 CDS An15g06950 84593257 complement(join(1649804..1650884,1651245..1651330)) III 1 NT_166530.1 Remark: A. niger var. awamori contains multiple copies of a transposable element, Vader.; Remark: the predicted A. niger ORF contains 16 possible sequencing errors leading to stop codons and frame-shifts and therefore likely is a pseudogene.; Remark: this 437-bp element caused a 2-bp duplication (TA) of the target sequence in A. niger var. awamori and A. niger.; Title: strong similarity to hypothetical transposable element Tan1 - Aspergillus niger [putative pseudogene]; putative pseudogene; See PMID 8625427; 1651330 84593257 An15g06950 Aspergillus niger 1649804 R 5061 CDS An15g06960 4988297 join(1653642..1653685,1653719..1655493,1655533..1655666) III 1 NT_166530.1 Title: weak similarity to hypothetical regulator protein CAB16735.1 - Schizosaccharomyces pombe; uncharacterized protein 1655666 4988297 An15g06960 Aspergillus niger uncharacterized protein XP_059604730.1 1653642 D 5061 CDS An15g06970 4988298 complement(join(1656975..1657288,1657356..1657810,1657871..1657994,1658062..1658188,1658245..1658385)) III 1 NT_166530.1 Catalytic activity: sterigmatocystin 7-O-methyltransferase of A. parasiticus catalyses the reaction S-adenosyl-L-methionine + sterigmatocystin = S-adenosyl-L-homocysteine + 7-O-methylsterigmatocystin.; Pathway: sterigmatocystin 7-O-methyltransferase of A. parasiticus is involved in aflatoxin biosynthesis.; Similarity: the predicted A. niger protein and sterigmatocystin 7-O-methyltransferase of A. parasiticus belong to the superfamily of O-methyltransferases.; Title: strong similarity to methyltransferase B omtB - Aspergillus parasiticus; See PMID 7557460; See PMID 8285664; See PMID 8434913; uncharacterized protein 1658385 4988298 An15g06970 Aspergillus niger uncharacterized protein XP_001397224.1 1656975 R 5061 CDS An15g06980 4988299 join(1658439..1659017,1659071..1659732,1659788..1660769) III 1 NT_166530.1 Similarity: the predicted protein of A. niger shows similarity to hypothetical transcription regulatory proteins with GAL4-type zinc binuclear cluster domains of the yeasts S. pombe and S. cerevisiae.; Title: similarity to hypothetical transcription regulator protein CAD21130.1 - Schizosaccharomyces pombe; uncharacterized protein 1660769 4988299 An15g06980 Aspergillus niger uncharacterized protein XP_001397225.3 1658439 D 5061 CDS An15g06990 4988300 join(1661324..1662379,1662483..1663529) III 1 NT_166530.1 Title: similarity to hypothetical membrane protein YGL060w - Saccharomyces cerevisiae; uncharacterized protein 1663529 4988300 An15g06990 Aspergillus niger uncharacterized protein XP_059605568.1 1661324 D 5061 CDS An15g07000 4988301 complement(join(1663772..1663998,1664047..1665167,1665218..1665374,1665419..1665557)) III 1 NT_166530.1 Catalytic activity: phytase catalyses the reaction myo-inositol hexakisphosphate + H2O = D-myo-inositol 1,2,4,5,6-pentakisphosphate + orthophosphate.; Function: phytase as component of a feed composition for monogastric animals (e. g., pigs, poultry) enhances the nutritional value of plant material without the need for adding additional phosphate to the feed.; Function: the enzyme showed high activity with 4-nitrophenyl phosphate at a pH range of 3 to 5 and with phytic acid at a pH range of 2. 5 to 7. 5.; Function: the gene (phyA) encoding a heat-stable enzyme has been cloned from A. fumigatus and overexpressed in A. niger.; Remark: shows also high similarity to patent EP969089-A1 that describes a consensus protein sequence (included is A. niger).; Title: strong similarity to phytase phyA -Aspergillus fumigatus; extracellular/secretion proteins; See PMID 9143104; See PMID 10679211; See PMID 11195907; uncharacterized protein 1665557 4988301 An15g07000 Aspergillus niger uncharacterized protein XP_059605569.1 1663772 R 5061 CDS An15g07010 84593258 complement(join(1666402..1666586,1666694..1666782,1666804..1667082,1667136..1667251)) III 1 NT_166530.1 hypothetical protein 1667251 84593258 An15g07010 Aspergillus niger hypothetical protein XP_059605570.1 1666402 R 5061 CDS An15g07020 84593259 join(1667294..1667579,1667612..1667943) III 1 NT_166530.1 hypothetical protein 1667943 84593259 An15g07020 Aspergillus niger hypothetical protein XP_059605571.1 1667294 D 5061 CDS An15g07030 84593260 1668522..1669400 III 1 NT_166530.1 Catalytic activity: farnesyltranstransferase (GGPS1) of H. sapiens catalyses the reaction trans-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.; Complex: the human farnesyltranstransferase behaves as an oligomeric molecule with 280 kDa on a gel filtration column.; Function: farnesyltranstransferase (GGPS1) of H. sapiens synthesizes an important precursor of carotenoids and geranylgeranylated proteins such as small G proteins and for the regulation of a nuclear hormone receptor (LXR-RXR).; Remark: some forms of this enzyme will also use geranyl diphosphate and dimethylallyl diphosphate as donors; it will not use larger prenyl diphosphates as efficient donors.; Similarity: the predicted protein of A. niger shows similarity to geranylgeranyl diphosphate synthases, which are officially named farnesyltranstransferases.; Title: strong similarity to geranylgeranyl diphosphate synthase GGPS1 - Homo sapiens; See PMID 10101267; uncharacterized protein 1669400 84593260 An15g07030 Aspergillus niger uncharacterized protein XP_059605572.1 1668522 D 5061 CDS An15g07040 4988305 complement(join(1671199..1671882,1671931..1674179,1674231..1674374,1674432..1674798,1674868..1675068)) III 1 NT_166530.1 Catalytic activity: phospholipase D (SPO14) of S. cerevisiae catalyses the reaction phosphatidylcholine + H(2)O = choline + phosphatidatephenol.; Function: the SPO14 gene encodes a phospholipase D (PLD) that is essential for meiosis. analysis of two mutant proteins, one with a point mutation that inactivated the PLD activity (Spo14pK--> H) and one with an amino-terminal deletion (Spo14pDeltaN) which doid not affect PLD activity demonstrated that these mutants could not restore meiosis in a spo14 deletion strain.; Localization: Spo14p is initially distributed throughout the cell, becomes concentrated at the spindle pole bodies after the meiosis I division, and at meiosis II localizes to the new spore membrane as it surrounds the nuclei and then expands to encapsulate the associated cytoplasm during the formation of spores.; Pathway: SPO14p of S. cerevisiae is involved in glycerolipid metabolism and phospholipid degradation.; Remark: the catalytically inactive protein also undergoes relocalization during meiosis; however, in the absence of PLD activity, no membrane is formed. in contrast, Spo14pDeltaN does not relocalize properly, indicating that the failure of this protein to complement a spo14 mutant is due to its inability to localize its PLD activity.; Similarity: the predicted A. niger protein shows strong similarity to the superfamily of phospholipase D. similarity is restricted to a domain of approximately 400 amino acids.; Title: strong similarity to phospholipase D Spo14 -Saccharomyces cerevisiae; See PMID 9425156; See PMID 10425393; See PMID 1582554; uncharacterized protein 1675068 4988305 An15g07040 Aspergillus niger uncharacterized protein XP_001397231.1 1671199 R 5061 CDS An15g07050 4988306 complement(join(1676060..1676956,1677003..1677025,1677074..1678043,1678111..1678254)) III 1 NT_166530.1 Catalytic activity: phenol hydroxylase of T. cutaneum catalyses the reaction phenol + NADPH + O(2) = catechol + NADP(+) + H(2)O.; Pathway: phenol hydroxylase of T. cutaneum is involved in phenylalanine metabolism and catabolism of aromates.; Remark: phenol hydroxylase of T. cutaneum is inhibited by excess phenol.; Similarity: the predicted A. niger protein shows particularly strong similarity to fungal phenol hydroxylases, which belong to the FAD-dependent oxidoreductases.; Title: strong similarity to phenol hydroxylase -Trichosporon cutaneum; See PMID 1429434; uncharacterized protein 1678254 4988306 An15g07050 Aspergillus niger uncharacterized protein XP_059605573.1 1676060 R 5061 CDS An15g07060 4988307 complement(join(1678825..1680962,1681033..1681087)) III 1 NT_166530.1 Remark: the gene zas1 of S. pombe encodes putative C2H2 zinc finger proteins that may be due to alternative splicing of zas1 hnRNA.; Title: similarity to hypothetical C2H2 zinc finger protein Zas1A - Schizosaccharomyces pombe; See PMID 10718196; uncharacterized protein 1681087 4988307 An15g07060 Aspergillus niger uncharacterized protein XP_001397233.3 1678825 R 5061 CDS An15g07070 4988308 join(1682183..1682203,1682271..1682710,1682763..1682784) III 1 NT_166530.1 Catalytic activity: cyanase of E. coli catalyses the reaction cyanate + bicarbonate = CO(2) + carbamate.; Remark: cyanase of E. coli belongs to the cyanate-inducible cyn operon. the cyn operon comprises approximately 2600 base pairs and includes cynT, cynS, and cynX, which encode cyanate permease, cyanase, and a protein of unknown function, respectively.; Remark: the covalent structure of cyanase is made up of a cynS dimer which is linked by a disulfide bond between the single cystine residue. the native enzyme (Mr 150,000) then appears to be a complex of four or five such subunit dimers.; Remark: the cyn operon of E. coli is located next to the lac operon, and the direction of cynS transcription was opposite that of lac.; Similarity: the predicted A. niger protein is similar to conserved procaryotic and plant cyanases.; Title: strong similarity to cyanate lyase cynS -Escherichia coli; cytoplasm; uncharacterized protein 1682784 4988308 An15g07070 Aspergillus niger uncharacterized protein XP_001397234.1 1682183 D 5061 CDS An15g07080 4988309 join(1683231..1683479,1683554..1684191,1684251..1684497) III 1 NT_166530.1 Remark: CTCF of G. gallus binds to a specific DNA region of the c-myc promoter and is important for chicken c-myc transcription.; Remark: six major nuclear isoforms of CTCF protein are differentially expressed in different chicken cell lines and tissues.; Remark: the DNA-binding domain of CTCF of G. gallus is composed of 11 Zn fingers: 10 are of C2H2 class, and 1 is of C2HC class.; Similarity: the predicted A. niger protein and CTCF of G. gallus shows similarity to zinc- finger transcription factors.; Title: similarity to zinc-finger transcription factor CTCF - Gallus gallus; nucleus; See PMID 8246978; uncharacterized protein 1684497 4988309 An15g07080 Aspergillus niger uncharacterized protein XP_001397235.1 1683231 D 5061 CDS An15g07090 4988310 complement(join(1684930..1684975,1685045..1685109,1685183..1685323)) III 1 NT_166530.1 Remark: the predicted A. niger ORF is encoded entirely by the ESTs an_3153 and an_2361 of A. niger.; Title: strong similarity to hypothetical protein encoded by An12g10350 - Aspergillus niger; uncharacterized protein 1685323 4988310 An15g07090 Aspergillus niger uncharacterized protein XP_001397236.1 1684930 R 5061 CDS An15g07100 84593261 join(1686923..1687017,1687096..1687185,1687327..1687496,1687589..1687698) III 1 NT_166530.1 hypothetical protein 1687698 84593261 An15g07100 Aspergillus niger hypothetical protein XP_059605574.1 1686923 D 5061 CDS An15g07110 4988312 join(1688050..1688970,1689032..1689172) III 1 NT_166530.1 Catalytic activity: homocysteine S-methyltransferase AtHMT-1 of A. thaliana catalyses the reaction S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine.; Cofactor: homocysteine S-methyltransferase AtHMT-1 of A. thaliana may require zinc as a cofactor.; Function: AtHMT-1 of A. thaliana catalyses methyl transfer from S-methylmethionine or S-adenosylmethionine (less efficient) to homocysteine, selenohomocysteine and less efficiently selenocysteine.; Remark: AtHMT-1 of A. thaliana complements an Escherichia coli yagD mutant, which lacks HMT (SMM:Hcy S-methyltransferase) activity.; Remark: AtHMT-1 of A. thaliana is strongly inhibited by methionine.; Similarity: the predicted A. niger protein belongs to the homocysteine S-methyltransferases.; Title: strong similarity to homocysteine S-methyltransferase AtHMT-1 - Arabidopsis thaliana; See PMID 10747987; uncharacterized protein 1689172 4988312 An15g07110 Aspergillus niger uncharacterized protein XP_001397238.1 1688050 D 5061 CDS An15g07120 4988313 complement(join(1689323..1689439,1689496..1689836,1689892..1691074)) III 1 NT_166530.1 Remark: prnB of A. nidulans encodes the major proline transport system and is part of a cluster of four genes necessary and sufficient for the utilization of proline as sole nitrogen and/or carbon source.; Remark: the proline utilisation gene cluster of A. nidulans can be repressed efficiently only when both repressing nitrogen and repressing carbon sources are present.; Title: strong similarity to proline permease prnB -Aspergillus nidulans; plasma membrane; See PMID 8437566; See PMID 9140969; See PMID 10613888; uncharacterized protein 1691074 4988313 An15g07120 Aspergillus niger uncharacterized protein XP_001397239.3 1689323 R 5061 CDS An15g07130 84593262 1692364..1692942 III 1 NT_166530.1 Similarity: similarity of the predicted A. niger protein and various protein sequences is due to low complexity sequences.; Title: weak similarity to hypothetical protein M01E5.4 - Caenorhabditis elegans; uncharacterized protein 1692942 84593262 An15g07130 Aspergillus niger uncharacterized protein XP_059605575.1 1692364 D 5061 CDS An15g07140 4988315 complement(1693671..1694705) III 1 NT_166530.1 Title: strong similarity to hypothetical protein encoded by An13g01800 - Aspergillus niger; uncharacterized protein 1694705 4988315 An15g07140 Aspergillus niger uncharacterized protein XP_001397241.1 1693671 R 5061 CDS An15g07150 4988316 complement(join(1695604..1696342,1696393..1698578,1698633..1699025)) III 1 NT_166530.1 Catalytic activity: DNA polymerase delta of S. pombe catalyses the reaction n deoxynucleoside triphosphate = n pyrophosphate + DNA(n).; Complex: highly purified, active spPol delta of S. pombe was shown to contain at least four distinct subunits,a large catalytic subunit Pol3, and three smaller subunits Cdc1, Cdc27, and Cdm1 with molecular masses of 125, 51, 42, and 19 kDa, respectively.; Function: DNA polymerase delta of S. pombe possesses two enzymatic activities: DNA synthesis (polymerase) and a 3' to 5' exonucleolytic activity that degrades single stranded DNA.; Remark: aphidicolin inhibits DNA polymerase delta of S. pombe, but not DNA polymerase alpha.; Similarity: the predicted protein of A. niger shows strong similarity to the large subunit (delta chain) of DNA- directed DNA polymerases, which belong to the DNA polymerase type-B family.; Title: strong similarity to catalytic subunit of DNA-directed DNA polymerase delta ol3p -Schizosaccharomyces pombe; nucleus; See PMID 10671561; See PMID 1960723; uncharacterized protein 1699025 4988316 An15g07150 Aspergillus niger uncharacterized protein XP_001397242.1 1695604 R 5061 CDS An15g07160 4988317 complement(join(1700335..1701058,1701118..1701202,1701258..1701879)) III 1 NT_166530.1 Catalytic activity: pectin lyases catalyse the eliminative cleavage of pectin to give oligosaccharides with terminal 4-deoxy-6-methyl-alpha-D-galact-4-enuronosyl groups.; Remark: Aspergillus niger pectin lyases are encoded by a multigene family with five characterized members (pelA, B, C, D, E and F).; Remark: microbial pectin and pectate lyases are virulence factors that degrade the pectic components of the plant cell wall. the homogalacturan backbone of pectin varies in its degree of methylation from the highly methylated and relatively hydrophobic form known as pectin,to the fully demethylated and highly charged form known as pectate. methylated and demethylated regions of pectin are cleaved by pectin lyase and calcium-dependent pectate lyases, respectively. protein engineering of lyases specific for particular patterns of methylation, will yield modified pectins of high value to the food and pharmaceutical industries.; Remark: pectin lyases A and D (formerly known as PLII and PLI, respectively) are the major components of the commercial pectinase preparation Ultrazym.; Title: strong similarity to pectin lyase pelA -Aspergillus niger; See PMID 9195887; See PMID 1934134; See PMID 2225145; uncharacterized protein 1701879 4988317 An15g07160 Aspergillus niger uncharacterized protein XP_001397243.1 1700335 R 5061 CDS An15g07170 84593263 complement(join(1702147..1702445,1702693..1702831)) III 1 NT_166530.1 hypothetical protein 1702831 84593263 An15g07170 Aspergillus niger hypothetical protein XP_059605576.1 1702147 R 5061 CDS An15g07180 84593264 join(1703151..1703399,1703515..1703586,1703682..1703771) III 1 NT_166530.1 hypothetical protein 1703771 84593264 An15g07180 Aspergillus niger hypothetical protein XP_059605577.1 1703151 D 5061 CDS An15g07190 4988320 1703946..1705010 III 1 NT_166530.1 Induction: the ZRT1 gene is induced at the transcriptional level by low intracellular concentration of zinc.; Remark: Zrt1p of S. cerevisiae (also known as YGL255W or NRC376) is a high-affinity zinc transport protein.; Remark: the protein sequence of patent WO9745000-A1 (ID-# AAW41170) is identical to Zrt1p of S. cerevisiae,although the description refers to a metal-regulated transporter (MRT) polypeptide of Arabidopsis thaliana and calls the protein ZRT2.; Similarity: the predicted amino acid sequence of Zrt1p of S. cerevisiae is similar to that of Irt1p, a probable Fe(II) transporter from Arabidopsis thaliana.; Title: strong similarity to high-affinity zinc transport protein Zrt1 - Saccharomyces cerevisiae; plasma membrane; See PMID 8637895; See PMID 9784581; See PMID 9786854; See PMID 10748254; uncharacterized protein 1705010 4988320 An15g07190 Aspergillus niger uncharacterized protein XP_001397246.1 1703946 D 5061 CDS An15g07200 4988321 1705476..1706417 III 1 NT_166530.1 Remark: the nucleotide sequence is highly similar to the 5'-EST BE760062 of Aspergillus niger.; Title: similarity to hypothetical transmembrane protein - Erysiphe pisi; uncharacterized protein 1706417 4988321 An15g07200 Aspergillus niger uncharacterized protein XP_001397247.1 1705476 D 5061 CDS An15g07210 84593265 complement(join(1706623..1706698,1706759..1706951,1707020..1707058,1707310..1707412,1707517..1707696,1707796..1707876)) III 1 NT_166530.1 hypothetical protein 1707876 84593265 An15g07210 Aspergillus niger hypothetical protein XP_059605578.1 1706623 R 5061 CDS An15g07220 4988323 join(1708015..1708103,1708156..1709572) III 1 NT_166530.1 Remark: the mutant upc2 of S. cerevisiae was identified by its impaired aerobic sterol exclusion and its simultanous hypersensitivity to Ca2+.; Similarity: the ORF of A. niger and UPC2 (YDR213W) of S. cerevisiae contain a Zn(II)2Cys6 binuclear cluster DNA binding domain.; Title: similarity to transcription activator Upc2 -Saccharomyces cerevisiae; See PMID 9696767; uncharacterized protein 1709572 4988323 An15g07220 Aspergillus niger uncharacterized protein XP_001397249.3 1708015 D 5061 CDS An15g07230 4988324 complement(join(1709713..1709905,1710015..1710278,1710435..1710529)) III 1 NT_166530.1 Remark: the nucleotide sequence of the ORF is found in many highly similar ESTs of A. niger.; Remark: this is the amino acid sequence of the rat thioredoxin 2 (TrX2), used in the method of the invention in protein repair. Trx2 proteins are translocated to mitochondria and are resistant to oxidation. mitochondria are the sites of vital cellular functions such as lipid metabolism and aerobic respiration (oxidative phosphorylation). in respiration, incomplete reduction of dioxygen results in the formation of reactive oxygen intermediates (ROIs) (hydrogen peroxide, the superoxide anion O2, and the hydroxyl radical OH). increased levels of ROIs, referred to as oxidative stress, can result in lipid peroxidation, inactivation of proteins and strand breakage in DNA. Thioredoxin can act as an antioxidant molecule and scavenge hydroxyl radicals, reduce hydrogen peroxide and reactive proteins inactivated by oxidation. more specifically, Trx2 may be used to protect against ischaemic damage (heart attacks and strokes), eye disease (acts as radio-protectant), radiation and drug toxicity.; Title: similarity to mitochondrial thioredoxin from patent WO9832863-A2 - Rattus sp.; uncharacterized protein 1710529 4988324 An15g07230 Aspergillus niger uncharacterized protein XP_059605579.1 1709713 R 5061 CDS An15g07240 4988325 join(1711150..1711219,1711407..1713325) III 1 NT_166530.1 Remark: the DNA sequence (AAT34137) which encodes the biosynthetic enzymes of icosapentaenoic acid (EPA) can be used to transform Escherichia coli. the DNA sequence allows efficient microbial production of EPA, which is a raw material for drugs, agrochemicals, foods and animal feedstuffs. EPA is also useful for lipid balance correction and as an antihypertensive, antiinflammatory and anticancer agent.; Title: strong similarity to icosapentaenoic acid synthase from patent WO9621735-A1 - Shewanella putrefaciens; uncharacterized protein 1713325 4988325 An15g07240 Aspergillus niger uncharacterized protein XP_001397251.3 1711150 D 5061 CDS An15g07250 4988326 complement(1713995..1716127) III 1 NT_166530.1 Function: human ankyrin-1 provides the primary linkage between the membrane skeleton and integral plasma membrane proteins.; Title: similarity to ankyrin B - Homo sapiens; See PMID 10810176; uncharacterized protein 1716127 4988326 An15g07250 Aspergillus niger uncharacterized protein XP_001397252.1 1713995 R 5061 CDS An15g07260 4988327 join(1716685..1716909,1716963..1717070,1717122..1717547,1717611..1717747,1717807..1717978,1718045..1718113) III 1 NT_166530.1 Similarity: the predicted A. niger protein shows strong similarity to several putative microbial and plant oxidoreductases and several patented sequences derived from Arabidopsis thaliana.; Title: strong similarity to hypothetical oxidoreductase PA0147 - Pseudomonas aeruginosa; uncharacterized protein 1718113 4988327 An15g07260 Aspergillus niger uncharacterized protein XP_001397253.3 1716685 D 5061 CDS An15g07270 84593266 join(1719133..1719255,1719310..1719547,1719598..1719783,1719837..1720075,1720143..1720286) III 1 NT_166530.1 Expression: CAR1 mRNA levels are low in growing cells, rise to peak expression at 5-10 hr of development when the cAMP signaling system is maximally active, and decrease as development proceeds.; Function: these receptors of D. discoideum coordinate the aggregation of individual cells into a multicellular organism and regulate the expression of a large number of developmentally regulated genes.; Similarity: the predicted protein of A. niger is similar to the multigene family of cell surface cyclic adenosine monophosphate (cAMP) receptors of D. discoideum which includes the chemoattractant receptor CAR1 .; Title: similarity to chemoattractant receptor CAR1 -Dictyostelium discoideum; plasma membrane; uncharacterized protein 1720286 84593266 An15g07270 Aspergillus niger uncharacterized protein XP_059605580.1 1719133 D 5061 CDS An15g07280 84593267 complement(join(1720815..1720871,1720988..1721224)) III 1 NT_166530.1 hypothetical protein 1721224 84593267 An15g07280 Aspergillus niger hypothetical protein XP_059605581.1 1720815 R 5061 CDS An15g07290 84593268 join(1721462..1721698,1721789..1722163) III 1 NT_166530.1 Title: weak similarity to hypothetical protein CAB92903.1 - Streptomyces coelicolor; uncharacterized protein 1722163 84593268 An15g07290 Aspergillus niger uncharacterized protein XP_059605582.1 1721462 D 5061 CDS An15g07300 4988331 join(1722397..1725109,1725200..1727199,1727249..1727884) III 1 NT_166530.1 Similarity: the 3' nucleotide sequence of the ORF shows strong similarity to two ESTs of A. niger (the 5'EST an_3564 and the 3'EST an_1208) and the 5'EST r7h08a1. r1 of A. nidulans.; Title: similarity to hypothetical protein encoded by An03g06670 - Aspergillus niger; uncharacterized protein 1727884 4988331 An15g07300 Aspergillus niger uncharacterized protein XP_059605583.1 1722397 D 5061 CDS An15g07310 84593269 join(1728204..1728420,1728719..1728956,1728987..1729600,1729660..1729811,1729899..1730594) III 1 NT_166530.1 Title: similarity to hypothetical protein YER080w -Saccharomyces cerevisiae; uncharacterized protein 1730594 84593269 An15g07310 Aspergillus niger uncharacterized protein XP_059605584.1 1728204 D 5061 CDS An15g07330 4988334 join(1732072..1732154,1732202..1733648) III 1 NT_166530.1 Title: similarity to hypothetical protein encoded by 17E5.150 - Neurospora crassa; uncharacterized protein 1733648 4988334 An15g07330 Aspergillus niger uncharacterized protein XP_059605585.1 1732072 D 5061 CDS An15g07340 84593270 1734236..1735249 III 1 NT_166530.1 Catalytic activity: the ezyme 4,5-dihydroxyphthalate decarboxylase of B. cepacia catalyzes the conversion of 4,5-dihydroxyphthalate to 3,4-dihydroxybenzoate and carbon dioxide.; Remark: 4,5-dihydroxyphthalate decarboxylase of B. cepacia participates in the aerobic phthalate degradation pathway.; Remark: the genes for phthalate degradation are arranged in at least three transcriptional units in B. cepacia. the gene for phthalate dioxygenase reductase (ophA1) is present by itself, while the genes for an inactive transporter (ophD) and 4,5-dihydroxyphthalate decarboxylase (ophC) are linked and the genes for phthalate dioxygenase oxygenase (ophA2) and cis-phthalate dihydrodiol dehydrogenase (ophB) are linked.; Title: strong similarity to 4,5-dihydroxyphthalate decarboxylase ophC - Burkholderia cepacia; See PMID 9851995; uncharacterized protein 1735249 84593270 An15g07340 Aspergillus niger uncharacterized protein XP_059605586.1 1734236 D 5061 CDS An15g07350 4988336 complement(join(1735457..1736993,1737024..1737135,1737229..1737328)) III 1 NT_166530.1 Title: strong similarity to hypothetical protein CAC28841.2 - Neurospora crassa; uncharacterized protein 1737328 4988336 An15g07350 Aspergillus niger uncharacterized protein XP_059605587.1 1735457 R 5061 CDS An15g07360 4988337 join(1738190..1738375,1738435..1738479,1738536..1738583,1738649..1739118,1739174..1739591,1739679..1739752,1739817..1739898) III 1 NT_166530.1 Function: the protein PRG3 is a flavin-oxidase that increases the intracellular content of reactive oxygen species (ROS).; Localization: PRG3 is localised in the cytoplasm.; Remark: PRG nucleotides, proteins and antibodies are useful as diagnostic and therapeutic agents for detection and treatment of cancer and other proliferative diseases. the gene/cDNA may be used for gene therapy, to restore a gene function downstream of p53, that cannot be activated in the p53-deficient tumour cell. Antibodies can be used as inducers of cell cycle arrest and/or apoptosis. The DNA sequences can be used to generate 'knockout' animals as a model of cancer susceptibility.; Remark: the patent match is against the translated DNA sequence of patent WO200012526-A1 (AC# AAZ51672).; Remark: the patented sequence is the complete cDNA of PRG3 gene, whose RNA levels are upregulated in response to induction of p53 activity in human colon cancer EB1 cells.; Similarity: the patented DNA sequence encodes the human homolog of Drosophila melanogaster peroxidasin and shares a motif with bacterial flavin-oxidases.; Title: strong similarity to PRG3 protein from patent WO200012526-A1 - Homo sapiens; cytoplasm; See PMID 10441517; uncharacterized protein 1739898 4988337 An15g07360 Aspergillus niger uncharacterized protein XP_001397262.3 1738190 D 5061 CDS An15g07370 4988338 complement(1740251..1740517) III 1 NT_166530.1 Similarity: similarity to the ORF CG4090 of D. melanogaster is due to a repeated sequence motif.; Title: similarity to hypothetical protein encoded by CG4090 - Drosophila melanogaster; uncharacterized protein 1740517 4988338 An15g07370 Aspergillus niger uncharacterized protein XP_001397263.1 1740251 R 5061 CDS An15g07380 84593271 join(1741033..1741126,1741173..1741352,1741474..1741881,1741968..1742034,1742118..1742168,1742250..1742341,1742394..1742521) III 1 NT_166530.1 hypothetical protein 1742521 84593271 An15g07380 Aspergillus niger hypothetical protein XP_059605588.1 1741033 D 5061 CDS An15g07390 4988340 complement(join(1745044..1745123,1745180..1746291,1746351..1746403)) III 1 NT_166530.1 Catalytic activity: GPD1 of S. cerevisiae catalyzes the reaction: sn-glycerol 3-phosphate + NAD(+) <=> glycerone phosphate + NADH.; Catalytic activity: glycerol-3-phosphate dehydrogenase (G3PDH) of S. cerevisiae catalyzes the reaction sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH.; Function: as osmotic balance regulates cell fusion during mating in S. cerevisiae, a secondary effect of GDP1 mutations is an impairment of cell fusion.; Function: whereas GDP1 is mainly involved in osmoregulation, GDP2 is required to regulate metabolism under anoxic conditions, when glycerol formation is strictly required as a redox sink for excess cytosolic NADH.; Induction: expression of GPD1 of S. cerevisiae is induced by osmotic stress.; Remark: GPD1 of S. cerevisiae is produced with an N-terminal extension that is removed from the functional enzyme; this extension does not target GDP1 to any organelle.; Similarity: S. cerevisiae has a second glycerol-3-phosphate dehydrogenase called GPD2, which is 69% identical to GPD1.; Similarity: the predicted ORF belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.; Title: strong similarity to glycerol-3-phosphate dehydrogenase (NAD+) precursor Gpd1 - Saccharomyces cerevisiae; cytoplasm; uncharacterized protein 1746403 4988340 An15g07390 Aspergillus niger uncharacterized protein XP_001397265.1 1745044 R 5061 CDS An15g07400 84593272 join(1746638..1746767,1746935..1747002,1747281..1747289,1747332..1747359,1747430..1747485,1747569..1747664,1747819..1747956) III 1 NT_166530.1 Remark: the ORF has an unusual exon/intron structure for A. niger.; hypothetical protein 1747956 84593272 An15g07400 Aspergillus niger hypothetical protein XP_059605589.1 1746638 D 5061 CDS An15g07460 4988347 1751591..1753990 III 1 NT_166530.1 Function: OPT1 of C. albicans was cloned from a C. albicans genomic library through heterologous expression in the S. cerevisiae di-/tripeptide transport mutant PB1X-9B. OPT1 restored oligopeptide transport in the mutant cells,as indicated by growth on the tetrapeptide Lys-Leu-Leu-Gly,sensitivity to toxic tetra- and pentapeptides, and an increase in the initial uptake rate of the radiolabelled tetrapeptide Lys-Leu-Gly-[3H]Leu.; Similarity: OPT1 of C. albicans is not a member of the ABC or PTR membrane transport families.; Title: strong similarity to oligopeptide transporter OPT1 - Candida albicans; See PMID 9043116; uncharacterized protein 1753990 4988347 An15g07460 Aspergillus niger uncharacterized protein XP_001397267.1 1751591 D 5061 CDS An15g07470 4988348 join(1754593..1754802,1754918..1754951,1755016..1755089,1755145..1755528) III 1 NT_166530.1 Function: M. grisea Pth11p can activate appressorium differentiation in response to inductive surface cues and repress differentiation on poorly inductive surfaces using multiple signaling pathways to mediate differentiation.; Similarity: the entire predicted A. niger protein is similar to the N-terminal region of M. grisea PTH11, which is approximately three times longer.; Title: similarity to surface recognition protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529; uncharacterized protein 1755528 4988348 An15g07470 Aspergillus niger uncharacterized protein XP_059605590.1 1754593 D 5061 CDS An15g07480 4988349 complement(join(1756295..1756424,1756512..1756634,1756749..1756957)) III 1 NT_166530.1 Similarity: similarities are due to low complexity sequence.; Title: weak similarity to hypothetical eggshell precursor protein - Schistosoma mansoni; See PMID 2911280; uncharacterized protein 1756957 4988349 An15g07480 Aspergillus niger uncharacterized protein XP_001397269.1 1756295 R 5061 CDS An15g07490 4988350 complement(join(1757865..1757960,1758018..1758240,1758486..1759102)) III 1 NT_166530.1 Remark: the 2,4-dichlorophenoxyacetate monooxygenase gene (tfdA) of A. eutrophus is localized on plasmid pJP4 together with five additional genes (tfdB, tfdC, tfdD, tfdE and tfdF). plasmid pJP4 permits its host bacterium, strain JMP134, to degrade and utilize as sole sources of carbon and energy 3-chlorobenzoate and 2,4-dichlorophenoxyacetic acid.; Title: strong similarity to 2,4-dichlorophenoxyacetate monooxygenase tfdA - Alcaligenes eutrophus; See PMID 3036764; uncharacterized protein 1759102 4988350 An15g07490 Aspergillus niger uncharacterized protein XP_059605591.1 1757865 R 5061 CDS An15g07500 4988351 1760268..1761293 III 1 NT_166530.1 Catalytic activity: ribokinase catalyses the reaction ATP + D-ribose = ADP + D-ribose 5-phosphate.; Pathway: ribokinase activates D- ribose for the pentose cycle.; Remark: ribokinase of E. coli has been cloned and purified to homogeneity. protein sequence analyses of peptides generated by cyanogen bromide cleavage and o-iodosobenzoic acid cleavage confirmed the translation initiation site and the reading frame of the DNA sequence. amino acid compositions of native ribokinase and the C-terminal dodecapeptide agree with the predicted amino acid compositions, confirming the accuracy of the DNA sequence and the translation termination site.; Remark: the patent match is against the translated DNA sequence 391 of patent WO0100844-A/391 (AC# AX065265),which covers corynebacterium glutamicum genes encoding proteins involved in carbon metabolism and energy production.; Similarity: the ribokinase of E. coli and the predicted A. niger protein are highly conserved in diverse procaryotic and eucaryotic organisms including H. sapiens.; Title: strong similarity to ribokinase rbsK -Escherichia coli; See PMID 3011794; uncharacterized protein 1761293 4988351 An15g07500 Aspergillus niger uncharacterized protein XP_001397271.1 1760268 D 5061 CDS An15g07510 4988352 complement(join(1761690..1763058,1763118..1763253,1763310..1763625,1764205..1764276)) III 1 NT_166530.1 Function: CaPTR2 of C. albicans is involved in the uptake of small peptides. plasmids encoding CaPTR2 restored peptide transport to peptide transport deficient mutants of S. cerevisiae as determined by uptake of radiolabelled dileucine, growth on dipeptides as sources of required amino acids, and restoration of growth inhibition by toxic peptides.; Remark: CaPTR2 of C. albicans was cloned from a C. albicans genomic library by functional complementation of a peptide transport deficient mutant (strain ptr2-2) of S. cerevisiae.; Remark: the patent match is against the protein sequence of patent WO9525114-A1 (AC# AAR84891). The patent covers the peptide transport protein ATPTR2Ap of Arabidopsis thaliana, which will be used to increase plant resistance to herbicidal peptide(s), preferentially those produced by a plant pathogen.; Similarity: the peptide transport gene (CaPTR2) of C. albicans belongs to the PTR2 family of transporters.; Title: strong similarity to peptide transport gene CaPTR2 - Candida albicans; plasma membrane; See PMID 7773409; uncharacterized protein 1764276 4988352 An15g07510 Aspergillus niger uncharacterized protein XP_059605592.1 1761690 R 5061 CDS An15g07520 4988353 complement(join(1765306..1765390,1765462..1765684,1765746..1765965)) III 1 NT_166530.1 Title: similarity to hypothetical protein mlr2143 -Mesorhizobium loti; uncharacterized protein 1765965 4988353 An15g07520 Aspergillus niger uncharacterized protein XP_001397273.1 1765306 R 5061 CDS An15g07530 4988354 complement(join(1767557..1767730,1767896..1771255,1771320..1784561,1784619..1785044)) III 1 NT_166530.1 Function: AM-toxin synthetase (AMT) is a primary determinant of virulence and specificity in the A. alternata apple pathotype/apple interaction.; Remark: Afternaria afternata apple pathotype causes Alternaria blotch of susceptible apple cultivars through the production of a cyclic peptide host-specific toxin,AM-toxin.; Title: strong similarity to cyclic peptide AM-toxin synthase AMT - Alternaria alternata; See PMID 10875335; uncharacterized protein 1785044 4988354 An15g07530 Aspergillus niger uncharacterized protein XP_059605593.1 1767557 R 5061 CDS An15g07540 84593273 join(1785268..1785337,1785425..1785483,1785569..1785676,1785760..1785892,1786000..1786066,1786203..1786364,1786435..1786525,1786602..1786751,1786857..1786928,1787004..1787080,1787167..1787331,1787410..>1787515) III 1 NT_166530.1 Remark: C-terminal truncated ORF due to end of contig.; hypothetical protein [truncated ORF] 1787515 84593273 An15g07540 Aspergillus niger hypothetical protein [truncated ORF] XP_059605594.1 1785268 D 5061 CDS An15g07550 4988356 join(1788679..1790013,1790077..1790136) III 1 NT_166530.1 Function: neutral amino acid permease Mtr of N. crassa is required for the transport of neutral aliphatic and aromatic amino acids via the N system.; Remark: the protein sequence of neutral amino acid permease Mtr of N. crassa is covered by patent WO9325663-A (AC# AAR47118). the patented Mtr of N. crassa is intended to be used as a selection marker.; Similarity: the predicted A. niger protein shows strong similarity to neutral amino acid permease Mtr of N. crassa and weak similarity to other amino acid transporters.; Title: strong similarity to neutral amino acid permease mtr - Neurospora crassa; See PMID 1838345; uncharacterized protein 1790136 4988356 An15g07550 Aspergillus niger uncharacterized protein XP_001397276.1 1788679 D 5061 CDS An15g07560 4988357 join(1791765..1791896,1791983..1792216,1792272..1792325) III 1 NT_166530.1 Title: similarity to hypothetical protein dag11 -Agaricus bisporus; uncharacterized protein 1792325 4988357 An15g07560 Aspergillus niger uncharacterized protein XP_001397277.1 1791765 D 5061 CDS An15g07570 4988358 join(1792685..1793030,1793080..1794063,1794137..1794258,1794318..1794650) III 1 NT_166530.1 Catalytic activity: arylsulfatase ars-1 of N. crassa catalyses the reaction: a phenol sulfate + H(2)O = a phenol + sulfate.; Remark: arylsulfatase of N. crassa is expressed under conditions of sulfur limitation and is under coordinate control of the cys-3+ and scon+ regulatory genes.; Title: strong similarity to arylsulfatase ars-1 -Neurospora crassa; See PMID 2528685; uncharacterized protein 1794650 4988358 An15g07570 Aspergillus niger uncharacterized protein XP_001397278.1 1792685 D 5061 CDS An15g07580 4988359 complement(join(1794864..1796140,1796191..1796368)) III 1 NT_166530.1 Function: fructosyl amine oxygen oxidoreductase of A. fumigatus oxidatively degrades glycated low molecular weight amines and amino acids under formation of hydrogen peroxide and glucosone.; Title: strong similarity to fructosyl amine oxygen oxidoreductase - Aspergillus fumigatus; See PMID 9013588; See PMID 9139700; uncharacterized protein 1796368 4988359 An15g07580 Aspergillus niger uncharacterized protein XP_001397279.1 1794864 R 5061 CDS An15g07590 4988360 join(1796995..1797119,1797166..1797393,1797445..1797539,1797586..1797675,1797719..1798647) III 1 NT_166530.1 Remark: ttuB codes for a protein with homology to transporter proteins and is required for entry of tartrate into bacteria.; Similarity: belongs to the allantoate permease family.; Title: strong similarity to tartrate transport protein ttuB - Agrobacterium vitis; plasma membrane; See PMID 7592429; uncharacterized protein 1798647 4988360 An15g07590 Aspergillus niger uncharacterized protein XP_001397280.1 1796995 D 5061 CDS An15g07600 4988361 join(1799233..1799509,1799560..1799673,1799742..1799835,1799927..1800323,1800382..1800903) III 1 NT_166530.1 Remark: the patent match is against the translated DNA sequence of patent EP1097998-A/6 (AC# AX135967), which covers the tetracycline resistance gene tetA.; Remark: the resistance protein TetA is a tetracycline/metal-proton antiporter located in the cytoplasmic membrane.; Similarity: the ORF shows weak similarity to some tetracycline resistance proteins.; Title: weak similarity to protein tetA from patent EP1097998-A - Corynebacterium glutamicum; See PMID 7826010; uncharacterized protein 1800903 4988361 An15g07600 Aspergillus niger uncharacterized protein XP_059602634.1 1799233 D 5061 CDS An15g07610 84593274 complement(join(1801179..1801378,1801467..1801562,1801654..1801729,1801786..1801848)) III 1 NT_166530.1 hypothetical protein 1801848 84593274 An15g07610 Aspergillus niger hypothetical protein XP_059602635.1 1801179 R 5061 CDS An15g07620 84593275 join(1801984..1802268,1802335..1802457) III 1 NT_166530.1 hypothetical protein 1802457 84593275 An15g07620 Aspergillus niger hypothetical protein XP_059602636.1 1801984 D 5061 CDS An15g07630 84593276 complement(1803271..1804716) III 1 NT_166530.1 Title: strong similarity to hypothetical protein encoded by An12g03510 - Aspergillus niger; uncharacterized protein 1804716 84593276 An15g07630 Aspergillus niger uncharacterized protein XP_059602637.1 1803271 R 5061 CDS An15g07640 84593277 join(1804910..1804967,1805013..1805047,1805095..1805213,1805342..1805470,1805522..1805593,1805697..1805831,1805911..1805950,1806034..1806117) III 1 NT_166530.1 hypothetical protein 1806117 84593277 An15g07640 Aspergillus niger hypothetical protein XP_059602638.1 1804910 D 5061 CDS An15g07650 84593278 complement(join(1806258..1806385,1806468..1806573,1806666..1806729,1806915..1807041,1807348..1807471,1807551..1807622,1807709..1807759)) III 1 NT_166530.1 hypothetical protein 1807759 84593278 An15g07650 Aspergillus niger hypothetical protein XP_059602639.1 1806258 R 5061 CDS An15g07660 84593279 join(1807798..1808091,1808175..1808270,1808483..1808626,1808716..1808830,1809084..1809271) III 1 NT_166530.1 hypothetical protein 1809271 84593279 An15g07660 Aspergillus niger hypothetical protein XP_059602640.1 1807798 D 5061 CDS An15g07670 4988368 complement(join(1809400..1809678,1809742..1810063,1810133..1810227,1810276..1810614)) III 1 NT_166530.1 Catalytic activity: monophenol monooxygenase of S. glaucescens catalyses the reaction L-tyrosine + L-DOPA + O(2) = L-DOPA + DOPAquinone + H(2)O.; Cofactor: monophenol monooxygenase of S. glaucescens requires copper as a cofactor.; Localization: intracellular and extracellular forms of monophenol monooxygenase of S. glaucescens were found to be indentical in molecular weight (29 000), in copper content (0. 21%), in the 19 amino acids at the amino-terminal end and in the ratio of cresolase to catecholase activity (0,005).; Pathway: monophenol monooxygenase plays a role in the metabolism of tyrosine and riboflavin and in the biosynthesis of flavonoids, stilbene and lignin as well as alkaloids.; Similarity: the predicted A. niger protein shows similarity to monophenol monooxygenase (tyrosinase) from S. glaucescens and many other organisms.; Title: similarity to monophenol monooxygenase tyrosinase - Streptomyces glaucescens; extracellular/secretion proteins; See PMID 3002431; See PMID 6804598; See PMID 1901488; uncharacterized protein 1810614 4988368 An15g07670 Aspergillus niger uncharacterized protein XP_059602641.1 1809400 R 5061 CDS An15g07680 84593280 join(1811369..1811500,1811549..1811625,1811706..1811790,1811869..1811928,1812051..1812177,1812272..1812375,1812580..1812621,1812745..1812884,1812974..1813121) III 1 NT_166530.1 hypothetical protein 1813121 84593280 An15g07680 Aspergillus niger hypothetical protein XP_059602642.1 1811369 D 5061 CDS An15g07690 84593281 complement(join(1813273..1813359,1813480..1813615,1813665..1813786,1813855..1813999,1814081..1814193)) III 1 NT_166530.1 hypothetical protein 1814193 84593281 An15g07690 Aspergillus niger hypothetical protein XP_059602643.1 1813273 R 5061 CDS An15g07700 4988371 1815294..1816091 III 1 NT_166530.1 Catalytic activity: aspergillopepsin II of A. niger hydrolyses peptide bonds in proteins, preferentially at Tyr-X, Phe-X, His-X, Asn-X, Asp-X, Gln-X, and Glu-X residues.; Inhibition: aspergillopepsin II of A. niger is a unique acid endopeptidase that is insensitive (or less sensitive) to specific inhibitors of ordinary acid or aspartic proteinases, such as pepstatin,diazoacetyl-DL-norleucine methyl ester, and 1,2-epoxy-3-(p-nitrophenoxy)-propane.; Remark: Glu-219 and Asp-123 are deduced to be the catalytic residues of aspergillopepsin II.; Remark: pH titration analysis using small-angle X-ray scattering (SAXS) as well as circular dichroism (CD) and gel filtration indicated that the enzyme was unfolded around a neutral pH with concomitant dissociation of the two chains.; Remark: the protein sequence of aspergillopepsin II precursor of A. niger is covered by patent JP04075586-A (AC# AAR22752). the patented aspergillopepsin II (proctase-A) is used to produce secreted acid protease for digestive enzyme preparations.; Similarity: the predicted A. niger protein shows strong similarity, but not identity, to aspergillopepsin II precursor (acid proteinase A) of A. niger, which is a non-pepsin-type acid proteinase and belongs to peptidase family A4.; Structure: aspergillopepsin II of A. niger has a unique two-chain structure with a 39-residue light (L) chain and a 173-residue heavy (H) chain linked noncovalently. the mature two-chain form is processed from the single peptide chain preproenzyme of 282 residues.; Title: strong similarity to aspergillopepsin II precursor (acid proteinase A) - Aspergillus niger; extracellular/secretion proteins; See PMID 7674918; See PMID 9058983; See PMID 10684617; See PMID 10854444; See PMID 1918060; uncharacterized protein 1816091 4988371 An15g07700 Aspergillus niger uncharacterized protein XP_001397291.1 1815294 D 5061 CDS An15g07710 4988372 complement(join(1816528..1816632,1816682..1816851,1816906..1816998,1817065..1817101)) III 1 NT_166530.1 Title: similarity to hypothetical membrane protein YJR085c - Saccharomyces cerevisiae; uncharacterized protein 1817101 4988372 An15g07710 Aspergillus niger uncharacterized protein XP_059602644.1 1816528 R 5061 CDS An15g07720 4988373 complement(join(1817862..1818484,1818544..1818688,1818751..1818885)) III 1 NT_166530.1 Catalytic activity: carboxyphosphonoenolpyruvate mutase of S. hygroscopicus catalyses the reaction 1-carboxyvinyl carboxyphosphonate = 3-(hydrohydroxyphosphoryl)pyruvate + CO(2).; Pathway: carboxyphosphonoenolpyruvate mutase is involved in the synthesis of bialaphos, a potent herbicide isolated from S. hygroscopicus.; Similarity: the predicted A. niger protein shows strong similarity to carboxyphosphonoenolpyruvate mutase of S. hygroscopicus and related sequences from other procaryotic species as well as some fungi and A. thaliana.; Title: strong similarity to carboxyphosphonoenolpyruvate mutase - Streptomyces hygroscopicus; cytoplasm; uncharacterized protein 1818885 4988373 An15g07720 Aspergillus niger uncharacterized protein XP_001397293.1 1817862 R 5061 CDS An15g07730 4988374 join(1819576..1819695,1819755..1819937,1819991..1820350,1820399..1820939,1820996..1821321,1821374..1821551,1821608..1821975) III 1 NT_166530.1 Catalytic activity: 3-isopropylmalate dehydratase (leu1) of R. niveus catalyses 3-isopropylmalate = 2-isopropylmaleate + H(2)O, but also 2-isopropylmaleate + H(2)O = 3-hydroxy-4-methyl-3-carboxypentanone).; Function: the R. niveus leul gene complements leucine auxotrophy of R. niveus M-37 (leu1-), which is deficient for alpha-IPMI.; Pathway: 3-isopropylmalate dehydratase catalyses the second step in leucine biosynthesis.; Similarity: the predicted A. niger protein shows strong similarity to 3-isopropylmalate dehydratase (leu1) of R. niveus, which belongs to the aconitase/IPM isomerase family.; Title: strong similarity to 3-isopropylmalate dehydratase leu1 - Rhizopus niveus; uncharacterized protein 1821975 4988374 An15g07730 Aspergillus niger uncharacterized protein XP_001397294.3 1819576 D 5061 CDS An15g07740 4988375 complement(join(1822116..1822867,1822932..1823194,1823258..1823695,1823744..1824086,1824162..1824268,1824326..1824486,1824630..1824650)) III 1 NT_166530.1 Function: the Leu3 protein of yeast is a dual-function regulator, stimulating transcription when the inducer alpha-isopropylmalate (alpha-IPM) is present and suppressing transcription when the inducer is absent.; Remark: yeast zinc cluster proteins form a major class of yeast transcriptional regulators. they usually bind as homodimers to target DNA sequences, with each monomer recognizing a CGG triplet. orientation and spacing between the CGG triplet specifies the recognition sequence for a given zinc cluster protein. Leu3p recognizes CGG triplets, but when oriented in opposite directions, an everted repeat.; Similarity: the predicted A. niger protein shows strong similarity to Leu3p, which belongs to the family of Zn(II)2Cys6 proteins.; Title: strong similarity to leucine-specific regulatory protein Leu3 - Saccharomyces cerevisiae; nucleus; See PMID 8428928; See PMID 8706857; See PMID 9660826; See PMID 10383402; uncharacterized protein 1824650 4988375 An15g07740 Aspergillus niger uncharacterized protein XP_059602645.1 1822116 R 5061 CDS An15g07750 84593282 join(1824802..1824882,1825186..1825270,1825369..1825386,1825438..1825617,1825750..1826003,1826098..1826184) III 1 NT_166530.1 hypothetical protein 1826184 84593282 An15g07750 Aspergillus niger hypothetical protein XP_059602646.1 1824802 D 5061 CDS An15g07760 4988377 1826361..1827368 III 1 NT_166530.1 Catalytic activity: purified manA of D. thermophilum hydrolyses 1,4-beta-D-mannosidic linkages in mannose,mannobiose, and mannotriose.; Pathway: manA of D. thermophilum is involved in fructose and mannose metabolism.; Remark: manA of D. thermophilum is a monomeric enzyme with an optimal temperature and pH for activity of 80 degrees C and 5. 0. in the absence of substrate, the enzyme showed no loss of activity at 80 degrees C over 16 h, while at 90 degrees C the enzyme had a half-life of 5. 4 min.; Similarity: the predicted A. niger protein shows strong similarity to beta-mannanase (manA) of D. thermophilum, which is a single-domain enzyme related to one group of beta-mannanases (glycosyl hydrolase family 26).; Title: strong similarity to beta-mannanase manA -Dictyoglomus thermophilum; extracellular/secretion proteins; See PMID 10525841; uncharacterized protein 1827368 4988377 An15g07760 Aspergillus niger uncharacterized protein XP_001397297.1 1826361 D 5061 CDS An15g07770 84593283 join(1827679..1827752,1827837..1827985,1828041..1828377,1828428..1828887) III 1 NT_166530.1 Remark: not all of the pregnancy-associated glycoproteins have the conserved active sites of the aspartic proteinase family and, therefore, may not be enzymatically active.; Similarity: the predicted A. niger protein shows weak similarity to pregnancy-associated glycoprotein 2 (PAG2) of S. scrofa, which, together with many other pregnancy-associated glycoproteins of S. scrofa and of ruminant species, belongs to the aspartic proteinase gene family (peptidase family A1).; Title: weak similarity to pregnancy-associated glycoprotein 2 PAG2 - Sus scrofa; See PMID 7669851; See PMID 9509990; uncharacterized protein 1828887 84593283 An15g07770 Aspergillus niger uncharacterized protein XP_059602647.1 1827679 D 5061 CDS An15g07780 84593284 join(1828995..1829133,1829175..1829292,1829593..1829624,1829695..1829831,1829912..1829983) III 1 NT_166530.1 hypothetical protein 1829983 84593284 An15g07780 Aspergillus niger hypothetical protein XP_059602648.1 1828995 D 5061 CDS An15g07790 4988380 complement(join(1830357..1830559,1830711..1830907,1830985..1831244)) III 1 NT_166530.1 Similarity: similarity of the predicted A. niger protein to various protein sequences is due to low complexity sequences (serine and threonine).; Title: similarity to hypothetical protein encoded by An11g02730 - Aspergillus niger; uncharacterized protein 1831244 4988380 An15g07790 Aspergillus niger uncharacterized protein XP_059602649.1 1830357 R 5061 CDS An15g07800 4988381 complement(join(1832415..1833070,1833141..1833192,1833257..1833331,1833382..1833472,1833522..1833684,1833742..1833850,1833905..1834060,1834114..1834217,1834330..1834384,1834450..1834692)) III 1 NT_166530.1 Title: strong similarity to precursor of alpha-amylase A - Aspergillus niger; See PMID 2340591; uncharacterized protein 1834692 4988381 An15g07800 Aspergillus niger uncharacterized protein XP_001397301.1 1832415 R 5061 CDS An15g07810 4988382 join(1836330..1836692,1836756..1836931,1836991..1837219,1837272..1837753,1837816..1838108,1838158..1838656,1838742..1839186,1839246..1841461,1841521..1841562,1841622..1842777,1842836..1843006,1843067..1843217,1843274..1843575,1843643..1844003,1844067..1844257,1844665..1844754) III 1 NT_166530.1 Title: strong similarity to hypothetical cell wall alpha-glucan synthase ags1p - Schizosaccharomyces pombe; uncharacterized protein 1844754 4988382 An15g07810 Aspergillus niger uncharacterized protein XP_059602650.1 1836330 D 5061 CDS An15g07820 4988383 join(1845029..1845205,1845281..1845403,1845464..1845589,1845643..1845843) III 1 NT_166530.1 hypothetical protein 1845843 4988383 An15g07820 Aspergillus niger hypothetical protein XP_001397303.1 1845029 D 5061 CDS An15g07830 4988384 join(1846429..1846660,1846761..1847132,1847221..1847708) III 1 NT_166530.1 Title: similarity to hypothetical protein attM -Agrobacterium tumefaciens; uncharacterized protein 1847708 4988384 An15g07830 Aspergillus niger uncharacterized protein XP_001397304.1 1846429 D 5061 CDS An15g07840 4988385 1848063..1848839 III 1 NT_166530.1 Title: similarity to alkyl salicylate esterase salE - Acinetobacter sp.; See PMID 10715011; uncharacterized protein 1848839 4988385 An15g07840 Aspergillus niger uncharacterized protein XP_001397305.1 1848063 D 5061 CDS An15g07850 84593285 join(1850272..1850336,1850384..1851047) III 1 NT_166530.1 hypothetical protein 1851047 84593285 An15g07850 Aspergillus niger hypothetical protein XP_059602651.1 1850272 D 5061 CDS An15g07860 4988387 complement(join(1851102..1851375,1851437..1851729,1851893..1852007,1852117..1852311,1852435..1852517)) III 1 NT_166530.1 Title: strong similarity to hypothetical short chain dehydrogenase SPCC736.13 - Schizosaccharomyces pombe; uncharacterized protein 1852517 4988387 An15g07860 Aspergillus niger uncharacterized protein XP_059602652.1 1851102 R 5061 CDS An15g07870 4988388 complement(1852983..1854095) III 1 NT_166530.1 Catalytic activity: An alcohol + NAD(+) <=> an aldehyde or ketone + NADH.; Cofactor: Zinc or Iron.; Remark: Acts on primary or secondary alcohols or hemiacetals. The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.; Title: strong similarity to alcohol dehydrogenase adhT - Bacillus stearothermophilus; See PMID 4578954; See PMID 436831; See PMID 1735726; uncharacterized protein 1854095 4988388 An15g07870 Aspergillus niger uncharacterized protein XP_001397308.1 1852983 R 5061 CDS An15g07880 4988389 complement(join(1855355..1855632,1855693..1856232,1856283..1856721,1856840..1856888,1856992..1857116)) III 1 NT_166530.1 Title: strong similarity to hypothetical hydroxylase A - Amycolatopsis orientalis; uncharacterized protein 1857116 4988389 An15g07880 Aspergillus niger uncharacterized protein XP_059602653.1 1855355 R 5061 CDS An15g07890 84593286 complement(join(1857798..1857802,1857961..1858508,1858562..1858674)) III 1 NT_166530.1 Title: similarity to protein c-fos - Xenopus laevis; See PMID 2632235; uncharacterized protein 1858674 84593286 An15g07890 Aspergillus niger uncharacterized protein XP_059602654.1 1857798 R 5061 CDS An15g07900 4988391 join(1859696..1859903,1859970..1860838,1860899..1860924,1860972..1861056,1861105..1861268,1861327..1861504) III 1 NT_166530.1 Title: strong similarity to cytochrome P450 -Myrothecium roridum; See PMID 9529523; uncharacterized protein 1861504 4988391 An15g07900 Aspergillus niger uncharacterized protein XP_001397311.1 1859696 D 5061 CDS An15g07910 4988392 join(1862045..1862404,1862454..1867736) III 1 NT_166530.1 Title: strong similarity to cyclic peptide AM-toxin synthase AMT - Alternaria alternata; See PMID 10875335; uncharacterized protein 1867736 4988392 An15g07910 Aspergillus niger uncharacterized protein XP_001397312.3 1862045 D 5061 CDS An15g07920 4988393 join(1868857..1869196,1869263..1869531,1869619..1870855,1870916..1872045,1872099..1873706,1873772..1873833,1873888..1875706,1875784..1876092,1876151..1876821,1876905..1877016) III 1 NT_166530.1 Title: strong similarity to lovastatin nonaketide synthase lovB - Aspergillus terreus; See PMID 10381407; See PMID 11378962; uncharacterized protein 1877016 4988393 An15g07920 Aspergillus niger uncharacterized protein XP_059602655.1 1868857 D 5061 CDS An15g07930 4988394 join(1878048..1878603,1878667..1878743,1878816..1879129,1879182..1879298,1879359..>1879820) III 1 NT_166530.1 Catalytic activity: L-arginine + N NADPH + M O(2) <=> citrulline + nitric oxide + N NADP(+).; Remark: truncated due to contig end.; Title: strong similarity to nitric-oxide synthase -Manduca sexta [truncated ORF]; See PMID 9736646; uncharacterized protein 1879820 4988394 An15g07930 Aspergillus niger uncharacterized protein XP_059602656.1 1878048 D 5061 CDS An02g00010 4979615 join(26..78,160..574) IV 1 NT_166519.1 Remark: the ORF has an unusual exon/intron structure for A. niger.; hypothetical protein 574 4979615 An02g00010 Aspergillus niger hypothetical protein XP_001399139.1 26 D 5061 CDS An02g00020 84590178 complement(713..988) IV 1 NT_166519.1 Remark: the ORF is short in length (91 amino acids).; Similarity: the ORF shows over a stretch of ca. 40 amino acids strong similarity to the N-terminus of several yeast allantoin permeases (ca. 500 amino acids in length).; Title: similarity to hypothetical allantoate permease - Schizosaccharomyces pombe; uncharacterized protein 988 84590178 An02g00020 Aspergillus niger uncharacterized protein XP_059605924.1 713 R 5061 CDS An02g00030 4979640 complement(join(1606..2378,2434..2977)) IV 1 NT_166519.1 Function: S. cerevisiae ARO8 is specialised for aromatic amino acid and alpha-aminoadipate transamination.; Phenotype: a double mutant of ARO8 and ARO9 of S. cerevisiae is auxotroph for phenylalanine/tyrosine.; Title: strong similarity to aromatic aminotransferases I Aro8 - Saccharomyces cerevisiae; See PMID 9491082; See PMID 9491083; uncharacterized protein 2977 4979640 An02g00030 Aspergillus niger uncharacterized protein XP_059605925.1 1606 R 5061 CDS An02g00040 4979623 join(3736..4114,4171..4836,4891..5238,5291..5430) IV 1 NT_166519.1 Function: DAL5 of S. cerevisiae is a component of the allantoate transport system.; Remark: DAL5 of S. cerevisiae belongs to the allantoate permease family.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 3275614; uncharacterized protein 5430 4979623 An02g00040 Aspergillus niger uncharacterized protein XP_001399142.1 3736 D 5061 CDS An02g00050 4979626 join(5800..7196,7266..7488) IV 1 NT_166519.1 Function: pnba of B. subtilis hydrolysis several beta-lactam antibiotic pnb esters to the corresponding free acid and pnb alcohol.; Remark: pnba of B. subtilis belongs to the type-B carboxylesterase/lipase family.; Similarity: the ORF overlaps with pnba of B. subtilis N-terminally (up to amino acid 300).; Title: strong similarity to para-nitrobenzyl esterase pnba - Bacillus subtilis; See PMID 7828905; uncharacterized protein 7488 4979626 An02g00050 Aspergillus niger uncharacterized protein XP_001399143.1 5800 D 5061 CDS An02g00060 4979618 10494..12038 IV 1 NT_166519.1 Function: Mst-1 of A. muscaria transports monosaccharids via the plasma membrane.; Induction: Mst-1 of A. muscaria is upregulated by monosaccharids.; Remark: Mst-1 of A. muscaria belongs to the sugar transporter family.; Title: strong similarity to monosaccharide transporter AmMst-1 - Amanita muscaria; plasma membrane; See PMID 9487692; uncharacterized protein 12038 4979618 An02g00060 Aspergillus niger uncharacterized protein XP_001399144.1 10494 D 5061 CDS An02g00070 4979632 12833..13969 IV 1 NT_166519.1 Function: bah of S. hygroscopicus removes the N-acetyl group from bialaphos.; Pathway: bah of S. hygroscopicus catalyzes one of the final steps in the bialaphos biosynthetic pathway.; Remark: bah of S. hygroscopicus belongs to the 'GDXG' family of lipolytic enzymes.; Remark: bialaphos is an antibiotic.; Title: strong similarity to bialaphos acetylhydrolase bah - Streptomyces hygroscopicus; See PMID 2066341; See PMID 8688624; uncharacterized protein 13969 4979632 An02g00070 Aspergillus niger uncharacterized protein XP_059605926.1 12833 D 5061 CDS An02g00080 4979627 complement(14732..15307) IV 1 NT_166519.1 Catalytic activity: flhA of P. denitrificans catalyzes the reaction: formaldehyde + glutathione + NAD+ = S-formylglutathione + NADH.; Complex: flhA of P. denitrificans forms a tetramer.; Function: flhA of P. denitrificans is is essential for the oxidation of formaldehyde produced during methylotrophic growth.; Pathway: flhA of P. denitrificans is a component of the formaldehyde detoxification pathway.; Phenotype: mutation of flhA of P. denitrificans abolishes the bacterium's ability to grow on methanol,methylamine, or choline, whereas heterotrophic growth remains unaffected.; Title: strong similarity to NAD-GSH-dependent formaldehyde dehydrogenase flhA - Paracoccus denitrificans; deleted EC_number 1.2.1.1; See PMID 7798140; uncharacterized protein 15307 4979627 An02g00080 Aspergillus niger uncharacterized protein XP_001399146.1 14732 R 5061 CDS An02g00090 4979647 17548..18852 IV 1 NT_166519.1 Catalytic activity: prolidase of A. esteraromaticum hydrolyses Xaa-|-Pro dipeptides.; Similarity: the ORF overlaps with the A. niger EST an_2700 in EMBLEST:BE759786 at it's C-terminus.; Title: strong similarity to prolidase -Aureobacterium esteraromaticum; See PMID 9989239; uncharacterized protein 18852 4979647 An02g00090 Aspergillus niger uncharacterized protein XP_001399147.1 17548 D 5061 CDS An02g00100 4979639 complement(join(19415..19789,19864..20388)) IV 1 NT_166519.1 Localization: est of A. calcoaceticus is external to the cytoplasmic membrane.; Phenotype: est mutants of A. calcoaceticus loose the ability to grow on simple triglycerides such as triacetin,but they are still able to grow on acetate.; Remark: A. calcoaceticus is an oil-degrading bacterium.; Remark: est of A. calcoaceticus belongs to the 'gdxg' family of lipolytic enzymes.; Similarity: the ORF is aligned to the est of A. calcoaceticus N-terminally (up to amino acid 236) and the alignement encompasses 3 gaps (with one gap > 20 amino acids).; Title: similarity to esterase est - Acinetobacter calcoaceticus; See PMID 2545531; uncharacterized protein 20388 4979639 An02g00100 Aspergillus niger uncharacterized protein XP_059605927.1 19415 R 5061 CDS An02g00110 4979624 22533..23489 IV 1 NT_166519.1 Title: strong similarity to hypothetical protein encoded by An11g10340 - Aspergillus niger; uncharacterized protein 23489 4979624 An02g00110 Aspergillus niger uncharacterized protein XP_001399149.1 22533 D 5061 CDS An02g00120 4979619 complement(join(24371..24800,24862..24995,25054..25179)) IV 1 NT_166519.1 hypothetical protein 25179 4979619 An02g00120 Aspergillus niger hypothetical protein XP_059605928.1 24371 R 5061 CDS An02g00130 84590179 join(25596..25666,25772..25883,26461..26535,26638..26679,26876..27184,27240..27419,27510..27551,27643..27867) IV 1 NT_166519.1 Remark: the ORF has an unusual exon/intron structure for A. niger with very long introns (> 500 bp).; Title: questionable ORF; uncharacterized protein 27867 84590179 An02g00130 Aspergillus niger uncharacterized protein XP_059605929.1 25596 D 5061 CDS An02g00140 4979621 complement(join(28383..29110,29166..29622,29682..30080)) IV 1 NT_166519.1 Catalytic activity: xynB of B. subtilis hydrolysis 1, 4-beta-D-xylans in removing successive D-xylose residues from the non-reducing termini.; Pathway: xynB of B. subtilis is involved xylan degradation/utilization.; Phenotype: the xynB mutant of B. subtilis is deficient in xylan utilization.; Similarity: the similarity of the ORF to xynB of B. subtilis is restricted to the first 400 amino acids (4/5 of the protein).; Title: strong similarity to xylan 1,4-beta-xylosidase xynB - Bacillus subtilis; See PMID 6413490; See PMID 9649739; uncharacterized protein 30080 4979621 An02g00140 Aspergillus niger uncharacterized protein XP_001399152.1 28383 R 5061 CDS An02g00150 4979625 complement(join(30332..30526,30580..30711,30767..30868,30915..31676,31737..31822,31863..32115)) IV 1 NT_166519.1 Function: pdat9 of N. haematococca detoxifies the phytoalexin pisatin.; Remark: pdat9 of N. haematococca was assigned to a new cytochrome P450 family, CYP57.; Remark: pisatin is an antimicrobial compound produced by pea in response to infection by N. haematococca.; Title: strong similarity to cytochrome P450 pisatin demethylase PDAT9 - Nectria haematococca; See PMID 8208242; See PMID 8755624; uncharacterized protein 32115 4979625 An02g00150 Aspergillus niger uncharacterized protein XP_059605930.1 30332 R 5061 CDS An02g00160 4979614 join(32492..32617,32896..33183,33231..33691,33854..34247) IV 1 NT_166519.1 Function: pth11 of M. grisea is not required for appressorium morphogenesis but is involved in host surface recognition; it represses differentiation on poorly inductive surfaces; Function: pth11 of M. grisea mediates appressorium differentiation in response to inductive substrate cues.; Localization: pth11 of M. grisea is found at the cell membrane and vacuoles.; Phenotype: pth11 mutants of M. grisea are nonpathogenic due to the defect in appressorium differentiation.; Remark: fungi infect plants by appressorium formation.; Title: strong similarity to appressorium differentiation protein pth11 - Magnaporthe grisea; See PMID 10521529; uncharacterized protein 34247 4979614 An02g00160 Aspergillus niger uncharacterized protein XP_059605931.1 32492 D 5061 CDS An02g00170 4979648 complement(join(34365..37321,37384..37432)) IV 1 NT_166519.1 Function: hyuA of Pseudomonas sp. hydrolyzes hydantoin.; Pathway: stereospecific conversion of DL-5-substituted hydantoins to the corresponding L-amino acids.; Similarity: the ORF overlaps solely N-terminal with the hyuA gene of Pseudomonas sp. (up to amino acid 398 of the ORF).; Title: similarity to hydantoin hydrolase hyuA -Pseudomonas sp.; See PMID 1732229; See PMID 9028051; uncharacterized protein 37432 4979648 An02g00170 Aspergillus niger uncharacterized protein XP_001399155.1 34365 R 5061 CDS An02g00180 4979631 complement(join(37868..38157,38209..39663,39748..39829)) IV 1 NT_166519.1 Function: pho-4 of N. crassa encodes a phosphate transporter.; Remark: pho-4 of N. crassa belongs to the pho-4 family of transporters.; Remark: pho-4 of N. crassa serves presumably as Na(+)-phosphate symporter, because phosphate uptake is stimulated 85-fold by the addition of Na+.; Repression: pho-4 of N. crassa is repressed by phosphate.; Similarity: the ORF overlaps with the A. niger EST an_2869 in EMBLEST:BE759926.; Title: strong similarity to phosphate-repressible phosphate permease pho-4 - Neurospora crassa; See PMID 2531109; See PMID 7732001; uncharacterized protein 39829 4979631 An02g00180 Aspergillus niger uncharacterized protein XP_059605932.1 37868 R 5061 CDS An02g00190 4979610 complement(join(40940..41967,42024..42451,42505..42800)) IV 1 NT_166519.1 Complex: the amdA protein of Rhodococcus forms a homodimer.; Remark: amdA of Rhodococcus belongs to the indoleacetamide hydrolases.; Similarity: the ORF overlaps with amdA only at it's N-terminus (up to amino acid 333).; Similarity: the ORF shows strong similarity to amidases and amidotransferases of various species.; Title: similarity to enantiomer-selective amidase amdA - Rhodococcus sp.; See PMID 1938876; uncharacterized protein 42800 4979610 An02g00190 Aspergillus niger uncharacterized protein XP_001399157.1 40940 R 5061 CDS An02g00200 4979629 join(44179..44400,44474..44982,45047..45575) IV 1 NT_166519.1 Function: pth11 of M. grisea is not required for appressorium morphogenesis but is involved in host surface recognition; it represses differentiation on poorly inductive surfaces.; Function: pth11 of M. grisea mediates appressorium differentiation in response to inductive substrate cues.; Localization: pth11 of M. grisea is found at the cell membrane and vacuoles.; Phenotype: pth11 mutants of M. grisea are nonpathogenic due to the defect in appressorium differentiation.; Remark: fungi infect plants by appressorium formation.; Similarity: the alignment of the ORF with pth11 of M. grisea excludes 88 C-terminal amino acids of the ORF and 111 N-terminal and 235 C-terminal amino acids of pth11.; Title: similarity to appressorium differentiation protein pth11 - Magnaporthe grisea; See PMID 10521529; uncharacterized protein 45575 4979629 An02g00200 Aspergillus niger uncharacterized protein XP_001399158.1 44179 D 5061 CDS An02g00210 4979636 48541..52371 IV 1 NT_166519.1 Function: mxaA of S. aurantiaca extends the assembled polyketide chain of the myxalamids with alanine.; Pathway: mxaA of S. aurantiaca is involved in myxalamid biosynthesis.; Remark: myxalamids are typical polyketide structures with incorporated amino acids.; Similarity: the ORF shows also similarity to other peptide synthetases.; Title: strong similarity to nonribosomal peptide synthase MxaA - Stigmatella aurantiaca; See PMID 11182319; uncharacterized protein 52371 4979636 An02g00210 Aspergillus niger uncharacterized protein XP_001399159.1 48541 D 5061 CDS An02g00220 4979633 complement(join(52734..52809,52873..53203,53271..53593,53643..53728)) IV 1 NT_166519.1 Function: the 17beta-HSD protein of C. lunatus catalyses the reduction of steroids and of nonsteroidal substrates.; Remark: 17beta-HSD of C. lunatus belongs to the short chain alcohol dehydrogenase/reductase family.; Remark: expression studies revealed that 17beta-HSD of C. lunatus is mainly expressed in the stationary phase of growth indicating its possible involvement in secondary metabolism.; Similarity: the ORF shows also strong similarity to oxygenase-reductases but these enzymes have about twice the length of the ORF and overlap with the ORF at their C-terminus.; Title: strong similarity to 17beta-hydroxysteroid dehydrogenase 17beta-HSDcl - Cochliobolus lunatus; See PMID 11165029; See PMID 9895285; See PMID 10624836; uncharacterized protein 53728 4979633 An02g00220 Aspergillus niger uncharacterized protein XP_001399160.1 52734 R 5061 CDS An02g00230 4979612 complement(join(54271..54622,54681..55126)) IV 1 NT_166519.1 Function: Fum9 of G. moniliformis is presumably involved in fumonisin biosynthesis.; Remark: fumonisins are mycotoxins found in infected maize and sorghum.; Title: similarity to hypothetical fumonisin biosynthesis protein FUM9 - Gibberella moniliformis; uncharacterized protein 55126 4979612 An02g00230 Aspergillus niger uncharacterized protein XP_059605933.1 54271 R 5061 CDS An02g00240 4979613 join(55801..56013,56080..56202,56252..56361,56420..56826,56871..57029,57129..57274,57327..57803) IV 1 NT_166519.1 Induction: GABA of A. nidulans is induced via the intA gene.; Repression: GABA of A. nidulans is subject of ammonium repression mediated by the areA gene.; Title: strong similarity to GABA permease gabA -Aspergillus nidulans; See PMID 375001; See PMID 10320578; uncharacterized protein 57803 4979613 An02g00240 Aspergillus niger uncharacterized protein XP_059605934.1 55801 D 5061 CDS An02g00250 4979635 complement(join(57859..58098,58132..58638)) IV 1 NT_166519.1 Catalytic activity: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.; Pathway: the dra protein of B. subtilis is involved in the nucleotide and deoxyribonucleotide catabolism.; Remark: the dra gene of B. subtilis is part of the dra-nupC-pdp operon.; Repression: the dra-nupC-pdp operon of B. subtilis is subject to glucose repression.; Title: strong similarity to deoxyribose-phosphate aldolase dra - Bacillus subtilis; cytoplasm; See PMID 8550462; uncharacterized protein 58638 4979635 An02g00250 Aspergillus niger uncharacterized protein XP_059605935.1 57859 R 5061 CDS An02g00260 4979616 complement(join(58884..59053,59102..60308,60477..60944,61000..61004,61361..61416,61548..61558)) IV 1 NT_166519.1 Function: acu-15 of N. crassa functions as a positive regulator of acetate induction.; Similarity: the ORF and acu-15 of N. crassa are aligned only at a stretch shorter than 200 amino acids and this alignment does not encompass the Zn2Cys6 DNA-binding domain of acu-15 of N. crassa or the leucine zipper of the ORF.; Similarity: the ORF shows also weak similarity to other (putative) transcription factors.; Similarity: the ORF shows strong similarity to the hypothetical protein encoded by An07g01280 from A. niger.; Title: weak similarity to hypothetical transcription activator protein acu-1 - Neurospora crassa; uncharacterized protein 61558 4979616 An02g00260 Aspergillus niger uncharacterized protein XP_059605936.1 58884 R 5061 CDS An02g00270 84590180 complement(join(62718..62813,62853..63071)) IV 1 NT_166519.1 Induction: it was reported that the mRNA for binA of A. nidulans was induced by bafilomycin.; Title: strong similarity to hypothetical protein binA - Aspergillus nidulans; uncharacterized protein 63071 84590180 An02g00270 Aspergillus niger uncharacterized protein XP_059605937.1 62718 R 5061 CDS An02g00280 84590181 join(63553..63612,63793..64113,64116..64180,64242..64344) IV 1 NT_166519.1 Function: the CefT protein confers resistance to some toxic organic acids, including isovaleric acid and phenylacetic acid.; Remark: 2 possible sequencing errors were corrected by intron insertion: the first putative error is located between exons 2 and 3 (1 bp missing) and the second is located between exons 3 and 4 (1 bp too much).; Similarity: the predicted ORF is about 280 amino acids shorter than several major facilitator protein homologs.; Title: similarity to multidrug resistant protein cefT - Acremonium chrysogenum [putative sequencing error]; See PMID 12172807; uncharacterized protein 64344 84590181 An02g00280 Aspergillus niger uncharacterized protein XP_059605938.1 63553 D 5061 CDS An02g00290 4979643 join(64897..65926,65993..66410,66494..67241) IV 1 NT_166519.1 Function: putative transcriptional regulator.; Title: strong similarity to hypothetical protein EAA61130.1 - Aspergillus nidulans; uncharacterized protein 67241 4979643 An02g00290 Aspergillus niger uncharacterized protein XP_059605939.1 64897 D 5061 CDS An02g00300 4979644 join(68162..68379,68467..68961,69017..69104) IV 1 NT_166519.1 Title: similarity to hypothetical protein MDB19 -Arabidopsis thaliana; uncharacterized protein 69104 4979644 An02g00300 Aspergillus niger uncharacterized protein XP_001399168.3 68162 D 5061 CDS An02g00310 4979645 complement(join(69480..70426,70492..70555)) IV 1 NT_166519.1 Remark: AFAR is a protein in rat liver cytosol that reduces aflatoxin B1-dialdehyde.; Similarity: shows similarity to several different oxidoreductases with different specificities.; Title: strong similarity to aflatoxin B1 aldehyde reductase AFAR - Rattus norvegicus; See PMID 8526867; See PMID 9331086; uncharacterized protein 70555 4979645 An02g00310 Aspergillus niger uncharacterized protein XP_001399169.1 69480 R 5061 CDS An02g00320 4979649 complement(join(70646..70784,70834..70896,71518..71916,72155..72369)) IV 1 NT_166519.1 Title: weak similarity to hypothetical biotin activation protein jhp1068 - Helicobacter pylori; uncharacterized protein 72369 4979649 An02g00320 Aspergillus niger uncharacterized protein XP_001399170.3 70646 R 5061 CDS An02g00330 4979628 72573..73094 IV 1 NT_166519.1 hypothetical protein 73094 4979628 An02g00330 Aspergillus niger hypothetical protein XP_001399171.1 72573 D 5061 CDS An02g00340 4979617 join(73691..73981,74037..74159,74210..74362,74412..75266,75315..75399,75450..75565) IV 1 NT_166519.1 Function: the A. oryzae amdS gene encodes an acetamidase enzyme that hydrolyses acetamide to acetate and ammonium thus providing A. oryzae with a source of carbon and nitrogen.; Title: strong similarity to acetamidase amds -Aspergillus oryzae; See PMID 1840550; uncharacterized protein 75565 4979617 An02g00340 Aspergillus niger uncharacterized protein XP_001399172.1 73691 D 5061 CDS An02g00350 4979637 complement(75868..77619) IV 1 NT_166519.1 Function: tannase (tannin acyl hydrolase) is a carboxylic ester hydrolase which hydrolyzes the ester bonds of tannic acid to produce gallic acid and glucose.; Title: strong similarity to precursor of tannase -Aspergillus oryzae; See PMID 8917102; uncharacterized protein 77619 4979637 An02g00350 Aspergillus niger uncharacterized protein XP_001399173.1 75868 R 5061 CDS An02g00360 84590182 join(77727..77866,78056..78397,78509..78731,78878..79003,79139..79210,79289..79384,79461..79478) IV 1 NT_166519.1 hypothetical protein 79478 84590182 An02g00360 Aspergillus niger hypothetical protein XP_059605940.1 77727 D 5061 CDS An02g00370 84590183 complement(join(79745..80897,81002..83097)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein encoded by An06g00670 - Aspergillus niger; uncharacterized protein 83097 84590183 An02g00370 Aspergillus niger uncharacterized protein XP_059605941.1 79745 R 5061 CDS An02g00380 84590184 join(83248..83416,83501..83811) IV 1 NT_166519.1 hypothetical protein 83811 84590184 An02g00380 Aspergillus niger hypothetical protein XP_059605942.1 83248 D 5061 CDS An02g00390 4979609 complement(join(84337..84442,84646..85038,85105..85478,85531..85635,85695..85865)) IV 1 NT_166519.1 Remark: PTH11 is a pathogenicity gene predicted to encode a novel transmembrane protein. pth11 mutants are nonpathogenic and it is suggested that the protein is involved in host surface recognition by functioning as an upstream effector of appressorium differentiation.; Similarity: shows similarity to central part of M. grisea PTH11 protein, might be a putative pseudogene.; Title: similarity to integral membrane protein PTH11 from patent WO9913094-A2 - Magnaporthe grisea; See PMID 10521529; uncharacterized protein 85865 4979609 An02g00390 Aspergillus niger uncharacterized protein XP_001399177.3 84337 R 5061 CDS An02g00400 4979620 join(86467..86682,86746..88356) IV 1 NT_166519.1 Similarity: show similarity to several prokaryotic and eukaryotic GMC oxidoreductases with different specificities.; Title: similarity to aryl-alcohol oxidase precursor aao - Pleurotus pulmonarius; See PMID 10606774; uncharacterized protein 88356 4979620 An02g00400 Aspergillus niger uncharacterized protein XP_001399178.1 86467 D 5061 CDS An02g00410 84590185 join(88741..88769,88812..88883,88983..89145) IV 1 NT_166519.1 hypothetical protein 89145 84590185 An02g00410 Aspergillus niger hypothetical protein XP_059605943.1 88741 D 5061 CDS An02g00420 4978523 complement(join(89478..89672,89765..90411,90501..90567,90774..90878,90929..91017,91058..91123,91210..91317,91395..91497)) IV 1 NT_166519.1 Similarity: the ORF shows similarity to several multi-drug transporter.; Title: similarity to multidrug resistance protein fnx1p - Schizosaccharomyces pombe; uncharacterized protein 91497 4978523 An02g00420 Aspergillus niger uncharacterized protein XP_059605944.1 89478 R 5061 CDS An02g00430 84590186 complement(join(91507..91629,91698..91913)) IV 1 NT_166519.1 hypothetical protein 91913 84590186 An02g00430 Aspergillus niger hypothetical protein XP_059605945.1 91507 R 5061 CDS An02g00440 4978525 complement(join(92015..92514,92571..92608,92714..92732,92803..92932,93190..93242,93338..93344)) IV 1 NT_166519.1 Title: weak similarity to dihydrofolate reductase dfr1p - Schizosaccharomyces pombe; See PMID 8088538; uncharacterized protein 93344 4978525 An02g00440 Aspergillus niger uncharacterized protein XP_059605946.1 92015 R 5061 CDS An02g00450 10098058 join(93601..94200,94257..94605,94688..94738,94816..94979,95032..95511,95578..95698,95751..95910,95965..96365,96411..96895,96898..96987,97052..98371,98430..98759,98795..98856,98919..99001,99083..99622,99691..100307,100310..100822,100878..101172,101258..102087) IV 1 NT_166519.1 Remark: 4 possible sequencing errors were predicted by genewise, which were corrected by (mini) intron insertions, at position 55739 (1 bp missing), at position 53016 (1 base missing), at position 52327 (1 bp missing),and at position 51457 (1 bp missing).; Title: strong similarity to lovastatin diketide synthase lovF - Aspergillus terreus [putative sequencing error]; See PMID 10334994; uncharacterized protein 102087 10098058 An02g00450 Aspergillus niger uncharacterized protein XP_059605947.1 93601 D 5061 CDS An02g00460 4978527 complement(103169..104875) IV 1 NT_166519.1 Protein sequence is in conflict with the conceptual translation; Title: similarity to hypothetical oxidoreductase ox1 - Claviceps purpurea [putative sequencing error]; putative sequencing error; uncharacterized protein 104875 4978527 An02g00460 Aspergillus niger uncharacterized protein XP_001399184.3 103169 R 5061 CDS An02g00470 4978528 join(106208..106403,106503..106543,106612..106991,107043..107107,107165..107553) IV 1 NT_166519.1 Localization: PTH11 of M. grisea was localised as a GFP-fusion protein in the cell membrane and in the vacuoles.; Phenotype: pth11 mutants of strain 4091-5-8 are nonpathogenic due to a defect in appressorium differentiation. This suggests that Pth11p functions at the cell cortex as an upstream effector of appressorium differentiation.; Title: similarity to transmembrane protein PTH11 -Magnaporthe grisea; See PMID 10521529; uncharacterized protein 107553 4978528 An02g00470 Aspergillus niger uncharacterized protein XP_059605948.1 106208 D 5061 CDS An02g00480 84590187 complement(join(108006..108085,108135..108194,108295..108349)) IV 1 NT_166519.1 Title: questionable ORF; uncharacterized protein 108349 84590187 An02g00480 Aspergillus niger uncharacterized protein XP_059605949.1 108006 R 5061 CDS An02g00490 4978530 join(109430..110094,110150..110822,110908..111799,112514..112719) IV 1 NT_166519.1 Title: weak similarity to mitochondrial precursor protein import receptor tom70 - Neurospora crassa; uncharacterized protein 112719 4978530 An02g00490 Aspergillus niger uncharacterized protein XP_059605950.1 109430 D 5061 CDS An02g00500 4978531 join(113267..113668,113718..113870) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein encoded by An07g03540 - Aspergillus niger; uncharacterized protein 113870 4978531 An02g00500 Aspergillus niger uncharacterized protein XP_059605951.1 113267 D 5061 CDS An02g00510 4978532 join(114196..114345,114402..114514,114574..114699,114895..114948,115021..115138,115348..115431) IV 1 NT_166519.1 Title: weak similarity to hypothetical protein encoded by YDL218w - Saccharomyces cerevisiae; uncharacterized protein 115431 4978532 An02g00510 Aspergillus niger uncharacterized protein XP_059605952.1 114196 D 5061 CDS An02g00520 84590188 join(117963..118080,118136..118263) IV 1 NT_166519.1 hypothetical protein 118263 84590188 An02g00520 Aspergillus niger hypothetical protein XP_059605953.1 117963 D 5061 CDS An02g00530 4978534 join(119087..119308,119370..119972,120037..120405) IV 1 NT_166519.1 Remark: Rsb1 of S. cerevisiae is predicted to be an integral membrane protein with seven transmembrane-spanning domains.; Remark: Rsb1 overproducing cells showed an ATP-dependen decrease in accumulation of exogenously added sphingosine and dihydrosphingosine because of their increased release.; Title: weak similarity to sphingoid long-chain base resistancy protein Rsb1 - Saccharomyces cerevisiae; See PMID 12034738; uncharacterized protein 120405 4978534 An02g00530 Aspergillus niger uncharacterized protein XP_059605954.1 119087 D 5061 CDS An02g00540 4978535 complement(join(120643..121110,121167..122628,122674..122900)) IV 1 NT_166519.1 Title: similarity to hypothetical transcription regulator protein CAA91958.1 - Schizosaccharomyces pombe; nucleus; uncharacterized protein 122900 4978535 An02g00540 Aspergillus niger uncharacterized protein XP_001399192.3 120643 R 5061 CDS An02g00550 4978536 122975..123958 IV 1 NT_166519.1 Remark: the gibberellin (GA) 20-oxidase encoded by the GA5 gene of Arabidopsis directs GA biosynthesis.; Similarity: shows similarity to several oxidoreductases.; Title: similarity to gibberellin 20-oxidase GA5 -Arabidopsis thaliana; See PMID 7604047; See PMID 10330476; uncharacterized protein 123958 4978536 An02g00550 Aspergillus niger uncharacterized protein XP_001399193.1 122975 D 5061 CDS An02g00560 4978537 complement(join(124105..124499,124562..125025,125072..125751,125798..126094,126124..126162)) IV 1 NT_166519.1 Remark: uapA of A. nidulans is a high-affinity,high-capacity specific xanthine/uric acid transporter; the region including amino acid residues 378-446 in UapA is critical for purine recognition and transport.; Title: strong similarity to uric acid-xanthine permease uapA - Aspergillus nidulans; See PMID 9670000; See PMID 10824738; uncharacterized protein 126162 4978537 An02g00560 Aspergillus niger uncharacterized protein XP_059605955.1 124105 R 5061 CDS An02g00570 4978538 join(126179..126646,126716..127708) IV 1 NT_166519.1 Function: atrazine chlorocyclohydrolase hydrolytically dechlorinates atrazine to hydroxyatrazine.; Pathway: atrazine chlorocyclohydrolase catalyzes the first step in atrazine degradation pathway.; Title: strong similarity to atrazine chlorocyclohydrolase atzA - Pseudomonas sp.; See PMID 8759853; See PMID 11010866; uncharacterized protein 127708 4978538 An02g00570 Aspergillus niger uncharacterized protein XP_001399195.1 126179 D 5061 CDS An02g00580 4978539 complement(127756..129306) IV 1 NT_166519.1 Function: pyruvate dehydrogenase phosphatase PDPc of B. taurus is a serine/threonine phosphatase removing the serine- or threonine-bound phosphate group from pyruvate dehydrogenase.; Title: similarity to pyruvate dehydrogenase phosphatase PDPc - Bos taurus; See PMID 8396421; uncharacterized protein 129306 4978539 An02g00580 Aspergillus niger uncharacterized protein XP_001399196.3 127756 R 5061 CDS An02g00590 4978540 complement(join(129844..130598,130668..131053,131103..131303,131361..131662)) IV 1 NT_166519.1 Title: strong similarity to high-affinity glucose transporter HGT1 - Kluyveromyces lactis; See PMID 8830679; uncharacterized protein 131662 4978540 An02g00590 Aspergillus niger uncharacterized protein XP_001399197.1 129844 R 5061 CDS An02g00600 84590189 complement(join(131930..132071,132200..132552,132632..132721,132762..132865,133205..133276,133527..133671,133755..133850)) IV 1 NT_166519.1 hypothetical protein 133850 84590189 An02g00600 Aspergillus niger hypothetical protein XP_059605956.1 131930 R 5061 CDS An02g00610 4978542 complement(join(134497..134794,134844..134974,135023..135163,135222..135437,135487..135890,135943..136392,136442..136769)) IV 1 NT_166519.1 Catalytic activity: beta-galactosidase catalyzes the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides.; Title: similarity to beta-galactosidase bgaM -Bacillus megaterium; See PMID 10322036; uncharacterized protein 136769 4978542 An02g00610 Aspergillus niger uncharacterized protein XP_059605957.1 134497 R 5061 CDS An02g00620 84590190 complement(join(136860..137149,137232..137357,137500..137539)) IV 1 NT_166519.1 Title: weak similarity to endometrium tumour EST encoded protein 15 from patent DE19817948-A1 - Homo sapiens; uncharacterized protein 137539 84590190 An02g00620 Aspergillus niger uncharacterized protein XP_059605958.1 136860 R 5061 CDS An02g00630 84590191 complement(137719..138303) IV 1 NT_166519.1 hypothetical protein 138303 84590191 An02g00630 Aspergillus niger hypothetical protein XP_059605959.1 137719 R 5061 CDS An02g00640 84590192 complement(join(138711..138845,138958..139061,139209..139407)) IV 1 NT_166519.1 hypothetical protein 139407 84590192 An02g00640 Aspergillus niger hypothetical protein XP_059605960.1 138711 R 5061 CDS An02g00650 84590193 join(139410..139487,139612..139658,139749..139889,139957..140043,140228..140337,140657..140934,141010..141281,141337..141448) IV 1 NT_166519.1 hypothetical protein 141448 84590193 An02g00650 Aspergillus niger hypothetical protein XP_059605961.1 139410 D 5061 CDS An02g00660 4978547 join(142215..143382,143430..145264) IV 1 NT_166519.1 Title: similarity to hypothetical protein CAC18275.2 - Neurospora crassa; uncharacterized protein 145264 4978547 An02g00660 Aspergillus niger uncharacterized protein XP_001399204.3 142215 D 5061 CDS An02g00670 4978548 join(145609..145649,145702..145795,145845..145899,145957..146156,146216..146739,146821..146884) IV 1 NT_166519.1 Catalytic activity: ketopantoate reductase catalyzes the conversion of (r)-pantoate + NADP+ = 2-dehydropantoate + NADPH.; Function: ketopantoate reductase catalyzes the nadph-dependent reduction of ketopantoate into pantoic acid.; Pathway: ketopantoate reductase is involved in the alternative pyrimidine biosynthetic (apb) pathway.; Remark: the encoded protein shows also similarities to ketopantoate reductases from other organisms.; Title: similarity to hypothetical protein encoded by all1319 - Nostoc sp.; uncharacterized protein 146884 4978548 An02g00670 Aspergillus niger uncharacterized protein XP_001399205.3 145609 D 5061 CDS An02g00680 4978549 complement(join(148444..148769,148824..148902,148961..148990)) IV 1 NT_166519.1 Title: weak similarity to hypothetical protein YMR192w - Saccharomyces cerevisiae; uncharacterized protein 148990 4978549 An02g00680 Aspergillus niger uncharacterized protein XP_001399206.1 148444 R 5061 CDS An02g00690 84590194 join(151333..151532,151574..151691,152122..152187) IV 1 NT_166519.1 hypothetical protein 152187 84590194 An02g00690 Aspergillus niger hypothetical protein XP_059605962.1 151333 D 5061 CDS An02g00700 4978551 complement(join(152519..153138,153194..153830)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein encoded by An02g06510 - Aspergillus niger; uncharacterized protein 153830 4978551 An02g00700 Aspergillus niger uncharacterized protein XP_001399208.1 152519 R 5061 CDS An02g00710 4978552 join(154305..154368,154437..154942,154978..155064,155131..155200,155256..155530,155655..155689,155743..155920,155989..156118,156204..156421) IV 1 NT_166519.1 Similarity: the ORF encoded protein shows weak similarity to many heat shock proteins.; Title: similarity to hypothetical protein CAE76621.1 - Neurospora crassa; uncharacterized protein 156421 4978552 An02g00710 Aspergillus niger uncharacterized protein XP_059605963.1 154305 D 5061 CDS An02g00720 84590195 complement(join(156948..157007,157083..157120,157191..157244,157356..157448,157541..157605,157683..157744)) IV 1 NT_166519.1 Title: questionable ORF; uncharacterized protein 157744 84590195 An02g00720 Aspergillus niger uncharacterized protein XP_059605964.1 156948 R 5061 CDS An02g00730 4978554 join(158335..158653,158755..158945,159018..159377) IV 1 NT_166519.1 Function: the Cutinase CutA from Botrytis cinerea catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle.; Function: the Cutinase allows pathogenic fungi to penetrate through the cuticular barrier into the host plant during the initial stage of the fungal infection.; Title: similarity to cutinase A gene CutA - Botrytis cinerea; extracellular/secretion proteins; See PMID 9002269; uncharacterized protein 159377 4978554 An02g00730 Aspergillus niger uncharacterized protein XP_001399211.1 158335 D 5061 CDS An02g00740 4978555 complement(join(159568..160072,160147..160385,160460..160805,160862..160965,161034..161324)) IV 1 NT_166519.1 Catalytic activity: 6-Hydroxy-D-nicotine oxidases convert (R)-6-hydroxynicotine + H(2)O + O(2) to 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H(2)O(2).; Cofactor: FAD.; Pathway: degradation of nicotine.; Title: similarity to 6-Hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 2115879; See PMID 2680607; See PMID 3622516; uncharacterized protein 161324 4978555 An02g00740 Aspergillus niger uncharacterized protein XP_001399212.1 159568 R 5061 CDS An02g00750 4978556 complement(join(161850..162148,162252..162319,162374..162448,162499..162708,162975..163026,163157..163346)) IV 1 NT_166519.1 Function: Pth11 from M. grisea is involved in surface dependent signal transduction during plant infection. Pth11 can activate appressorium differentiation in response to inductive surface cues and repress differentiation on poorly inductive surfaces.; Remark: the filamentous ascomycete Magnaporthe grisea is the blast pathogen of many grass species,including rice.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529; uncharacterized protein 163346 4978556 An02g00750 Aspergillus niger uncharacterized protein XP_059605965.1 161850 R 5061 CDS An02g00760 4978557 complement(join(163985..164348,164510..164665,165246..165445,165536..165911,165977..166713,166777..166890)) IV 1 NT_166519.1 Remark: the Flu1 gene product from C. albicans complements the fluconazole hypersusceptibility of a S. cerevisiae pdr5 mutant, lacking the ABC (ATP-binding cassette) transporter gene PDR5.; Title: similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353; uncharacterized protein 166890 4978557 An02g00760 Aspergillus niger uncharacterized protein XP_001399214.3 163985 R 5061 CDS An02g00770 84590196 complement(join(167475..167605,167802..167823)) IV 1 NT_166519.1 Title: questionable ORF; uncharacterized protein 167823 84590196 An02g00770 Aspergillus niger uncharacterized protein XP_059605966.1 167475 R 5061 CDS An02g00780 4978559 complement(join(168482..169147,169271..169806,169855..169869,169916..170075)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein PA2063 - Pseudomonas aeruginosa; uncharacterized protein 170075 4978559 An02g00780 Aspergillus niger uncharacterized protein XP_059605967.1 168482 R 5061 CDS An02g00790 84590197 complement(join(<170351..170483,170562..170612,170694..170906,170974..171109,171654..171782,171804..171874,171966..172001,172323..172363)) IV 1 NT_166519.1 hypothetical protein 172363 84590197 An02g00790 Aspergillus niger hypothetical protein XP_059605968.1 170351 R 5061 CDS An02g00800 84590198 join(172600..172919,173131..173215,173258..173485,173521..173549,173595..173665,173756..173790) IV 1 NT_166519.1 hypothetical protein 173790 84590198 An02g00800 Aspergillus niger hypothetical protein XP_059605969.1 172600 D 5061 CDS An02g00810 4978562 complement(join(174560..174897,174958..175394,175448..175571,175618..175747,175802..175978)) IV 1 NT_166519.1 Catalytic activity: S-Adenosyl-L-methionine + 6-Demethylsterigmatocystin = S-Adenosyl-L-homocysteine + Sterigmatocystin.; Function: O-Methyltransferase I catalyzes both the conversion of demethylsterigmatocystin to sterigmatocystin and the conversion of dihydrodemethylsterigmatocystin to dihydrosterigmatocystin during aflatoxin biosynthesis.; Pathway: aflatoxin biosynthesis.; Remark: aflatoxins are polyketide-derived secondary metabolites produced by the fungi Aspergillus flavus and Aspergillus parasiticus. Among the catalytic steps in the aflatoxin biosynthetic pathway, the conversion of sterigmatocystin to O-methylsterigmatocystin and the conversion of dihydrosterigmatocystin to dihydro-O-methylsterigmatocystin are catalyzed by an S-adenosylmethionine-dependent O-methyltransferase.; Remark: omtB of A. parasiticus is also called dmtA.; Title: strong similarity to O-methyltransferase B omtB - Aspergillus parasiticus; See PMID 8285664; See PMID 10543813; uncharacterized protein 175978 4978562 An02g00810 Aspergillus niger uncharacterized protein XP_001399219.1 174560 R 5061 CDS An02g00820 84590199 complement(join(176363..176496,176707..177015,177108..177262,177339..177424)) IV 1 NT_166519.1 hypothetical protein 177424 84590199 An02g00820 Aspergillus niger hypothetical protein XP_059605970.1 176363 R 5061 CDS An02g00830 84590200 join(178031..178162,178274..178319,178409..178573,178641..178688,178754..178846,179076..179315,179382..179467,179519..179576,179662..179804) IV 1 NT_166519.1 hypothetical protein 179804 84590200 An02g00830 Aspergillus niger hypothetical protein XP_059605971.1 178031 D 5061 CDS An02g00840 4978565 join(179874..180143,180193..180950,181002..182013,182064..183194) IV 1 NT_166519.1 Title: similarity to nonribosomal peptide synthase MxcG - Stigmatella aurantiaca; See PMID 11029592; uncharacterized protein 183194 4978565 An02g00840 Aspergillus niger uncharacterized protein XP_001399222.1 179874 D 5061 CDS An02g00850 4978566 complement(183804..186023) IV 1 NT_166519.1 Remark: putative mixed-linked glucanase but the homologe protein from Neurospora with the similar lenght is not described.; Title: strong similarity to hypothetical mixed-linked glucanase precursor related protein MLG1 -Neurospora crassa; uncharacterized protein 186023 4978566 An02g00850 Aspergillus niger uncharacterized protein XP_001399223.1 183804 R 5061 CDS An02g00860 84590201 complement(join(186448..186671,186795..186873,187122..187445,187505..187630,187720..187803,187893..187908,187987..188030)) IV 1 NT_166519.1 hypothetical protein 188030 84590201 An02g00860 Aspergillus niger hypothetical protein XP_059605972.1 186448 R 5061 CDS An02g00870 4978568 complement(join(188888..188986,189063..189142,189202..190156,190215..190571)) IV 1 NT_166519.1 Remark: the pap1+ gene is required for spk1(+)-conferred staurosporine resistance.; Title: similarity to transcription factor ap1p -Schizosaccharomyces pombe; See PMID 1899230; See PMID 10731689; uncharacterized protein 190571 4978568 An02g00870 Aspergillus niger uncharacterized protein XP_001399225.1 188888 R 5061 CDS An02g00880 4978569 complement(join(191428..192131,192185..192870,192926..193835,193892..194360)) IV 1 NT_166519.1 Remark: only the region of the MYND finger domain is found in all proteins.; Title: weak similarity to ubiquitin specific protease 15 UBP15 - Arabidopsis thaliana; See PMID 11115897; uncharacterized protein 194360 4978569 An02g00880 Aspergillus niger uncharacterized protein XP_059605973.1 191428 R 5061 CDS An02g00890 4978570 complement(join(194998..195083,195136..195226,195282..195474,195524..195709,195758..195783,195836..195958,196013..196181,196237..196411,196466..196584,196643..196749)) IV 1 NT_166519.1 Catalytic activity: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.; Pathway: glycine, serine and threonine metabolism; vitamin B6 metabolism.; Remark: the SER1 gene encodes 3-phosphoserine aminotransferase which catalyzes the formation of phosphoserine from 3-phosphohydroxy-pyruvate, which is obtained by oxidation of 3-phosphoglycerate, an intermediate of glycolysis.; Similarity: belongs to class-v of pyridoxal-phosphate-dependent aminotransferases.; Title: strong similarity to phosphoserine transaminase Ser1 - Saccharomyces cerevisiae; See PMID 7553933; See PMID 8017107; uncharacterized protein 196749 4978570 An02g00890 Aspergillus niger uncharacterized protein XP_001399227.1 194998 R 5061 CDS An02g00910 4978572 join(198158..198262,198314..198549,198602..198948,198995..199236) IV 1 NT_166519.1 Catalytic activity: vestitone + NADP+ = 2'-hydroxyformononetin + NADPH.; Remark: IFRH plays a distinct role in plant antioxidant defense and are possibly involved in NAD(P)/NAD(P)H homeostasis.; Similarity: belongs to the isoflavone reductases.; Title: similarity to 2-hydroxyisoflavone reductase IFRH - Arabidopsis thaliana; See PMID 7592828; uncharacterized protein 199236 4978572 An02g00910 Aspergillus niger uncharacterized protein XP_001399228.1 198158 D 5061 CDS An02g00920 84590202 complement(join(200161..200204,200263..200452)) IV 1 NT_166519.1 hypothetical protein 200452 84590202 An02g00920 Aspergillus niger hypothetical protein XP_059605974.1 200161 R 5061 CDS An02g00930 84590203 join(200807..200884,200959..201018,201103..201222) IV 1 NT_166519.1 hypothetical protein 201222 84590203 An02g00930 Aspergillus niger hypothetical protein XP_059605975.1 200807 D 5061 CDS An02g00950 84590204 join(201677..202121,202205..202644) IV 1 NT_166519.1 Remark: the ORF seems approximately 150 amino acids shorter than the Neurospora homolog.; Title: similarity to hypothetical protein B2A19.90 -Neurospora crassa; uncharacterized protein 202644 84590204 An02g00950 Aspergillus niger uncharacterized protein XP_059605976.1 201677 D 5061 CDS An02g00957 84590205 join(203227..203367,203615..203766,203830..204391) IV 1 NT_166519.1 Title: weak similarity to the transcription factor Pip2 - Saccharomyces cerevisiae; uncharacterized protein 204391 84590205 An02g00957 Aspergillus niger uncharacterized protein XP_059605977.1 203227 D 5061 CDS An02g00960 4978578 205045..205755 IV 1 NT_166519.1 Remark: a splice site upstream of the START codon was detected.; Similarity: the FrcK protein from Sinorhizobium meliloti shows homology with some kinases.; Title: strong similarity to kinase FrcK -Sinorhizobium meliloti; See PMID 11466273; uncharacterized protein 205755 4978578 An02g00960 Aspergillus niger uncharacterized protein XP_001399233.1 205045 D 5061 CDS An02g00970 4978579 complement(join(205899..206063,206135..206296,206390..206497)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein 13E11.200 - Neurospora crassa; uncharacterized protein 206497 4978579 An02g00970 Aspergillus niger uncharacterized protein XP_001399234.3 205899 R 5061 CDS An02g00980 4978580 join(207112..207254,207314..208778) IV 1 NT_166519.1 Remark: radixin is a capping protein for the barbed end of actin filaments and it is proposed to play a role in the association of actin filaments with the plasma membrane.; Similarity: to translation initiation factors eIF-2B but the protein seems approximately 200 aa to long.; Title: weak similarity to cytoskeletal protein radixin - Homo sapiens; uncharacterized protein 208778 4978580 An02g00980 Aspergillus niger uncharacterized protein XP_001399235.3 207112 D 5061 CDS An02g00990 4978581 complement(208894..210174) IV 1 NT_166519.1 Remark: putative amidohydrolase by similarity.; Title: strong similarity to amidohydrolase from patent WO0100843-A - Corynebacterium glutamicum; uncharacterized protein 210174 4978581 An02g00990 Aspergillus niger uncharacterized protein XP_001399236.1 208894 R 5061 CDS An02g01000 4978582 join(211805..211985,212036..212449,212526..212749,212807..213189,213252..213798) IV 1 NT_166519.1 Function: glutaryl 7-ACA acylase converts 7 beta-(4-carboxybutanamido)cephalosporanic acid (glutaryl 7-ACA) to 7-amino cephalosporanic acid (7-ACA).; Remark: extracellular excretion of the enzyme was observed in a recombinant strain of B. subtilis.; Remark: strong similarity to GL-7ACA aycylase Bacillus laterosporus J1 patent EP482844-A.; Title: strong similarity to glutaryl 7-ACA acylase precursor GL-7ACA - Bacillus laterosporus; See PMID 1744041; uncharacterized protein 213798 4978582 An02g01000 Aspergillus niger uncharacterized protein XP_001399237.1 211805 D 5061 CDS An02g01010 84590206 join(213901..214440,214865..215065) IV 1 NT_166519.1 hypothetical protein 215065 84590206 An02g01010 Aspergillus niger hypothetical protein XP_059605978.1 213901 D 5061 CDS An02g01020 84590207 complement(join(215133..215222,215358..215391,215447..215814)) IV 1 NT_166519.1 hypothetical protein 215814 84590207 An02g01020 Aspergillus niger hypothetical protein XP_059605979.1 215133 R 5061 CDS An02g01022 84590208 complement(215909..216145) IV 1 NT_166519.1 hypothetical protein 216145 84590208 An02g01022 Aspergillus niger hypothetical protein XP_059605980.1 215909 R 5061 CDS An02g01025 84590209 complement(join(216278..216337,216389..216409)) IV 1 NT_166519.1 hypothetical protein 216409 84590209 An02g01025 Aspergillus niger hypothetical protein XP_059605981.1 216278 R 5061 CDS An02g01030 84590210 join(216560..216622,216691..216977,217059..217173) IV 1 NT_166519.1 hypothetical protein 217173 84590210 An02g01030 Aspergillus niger hypothetical protein XP_059605982.1 216560 D 5061 CDS An02g01040 4978588 join(217512..217679,217900..217981,218042..218750,218829..218979) IV 1 NT_166519.1 Title: similarity to hypothetical protein EAA71860.1 - Gibberella zeae; uncharacterized protein 218979 4978588 An02g01040 Aspergillus niger uncharacterized protein XP_059605983.1 217512 D 5061 CDS An02g01050 4978589 complement(join(219257..219868,219942..220307,220364..220425,220487..220638,220701..220782,220854..220896)) IV 1 NT_166519.1 Catalytic activity: salicylate + NADH + O2 = catechol + NAD+ + H2O + CO2.; Pathway: phenylalanine metabolism.; Remark: nahG from Pseudomonas putida catalyzes the formation of catechol from salicylate, a key intermediate in naphthalene catabolism.; Similarity: belongs to the tetracycline 6-hydroxylase family.; Title: strong similarity to salicylate hydroxylase nahG - Pseudomonas putida; See PMID 6296054; See PMID 8328809; See PMID 1993181; uncharacterized protein 220896 4978589 An02g01050 Aspergillus niger uncharacterized protein XP_059605984.1 219257 R 5061 CDS An02g01060 84590211 join(221183..221373,221530..221567,221601..221709,221799..221973) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein encoded by An02g01130 - Aspergillus niger; uncharacterized protein 221973 84590211 An02g01060 Aspergillus niger uncharacterized protein XP_059605985.1 221183 D 5061 CDS An02g01070 4978591 join(223010..223325,223424..223531,223594..223866,223918..223949) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein encoded by An03g03570 - Aspergillus niger; uncharacterized protein 223949 4978591 An02g01070 Aspergillus niger uncharacterized protein XP_001399246.3 223010 D 5061 CDS An02g01080 4978592 complement(join(224059..224302,224361..225138,225248..225733,225789..226023)) IV 1 NT_166519.1 Title: similarity to hypothetical transcription regulator SPAC11D3.07c - Schizosaccharomyces pombe; uncharacterized protein 226023 4978592 An02g01080 Aspergillus niger uncharacterized protein XP_059605986.1 224059 R 5061 CDS An02g01090 4978593 join(226711..226747,226793..227324,227387..227465,227542..227613) IV 1 NT_166519.1 Function: the nor-1 ketoreductase from Aspergillus parasiticus may be involved in the dehydration of norsolorinic acid to form averantin.; Pathway: aflatoxin biosynthesis.; Remark: a mutation of nor-1 in Aspergillus parasiticus SU-1 blocks the aflatoxin B1 biosynthesis, and results in the accumulation of norsolorinic acid (NA).; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Similarity: belongs to the short-chain alcohol dehydrogenases.; Title: strong similarity to norsolorinic acid ketoreductase nor-1 - Aspergillus parasiticus; See PMID 7993094; uncharacterized protein 227613 4978593 An02g01090 Aspergillus niger uncharacterized protein XP_059605987.1 226711 D 5061 CDS An02g01100 4978594 join(228062..229167,229219..229387,229472..229776,229851..229935) IV 1 NT_166519.1 Remark: YOR273c (TPO4) is a polyamine transporter and it was detected on the vacuolar membrane. Cells overexpressing these gene were resistant to polyamine toxicity and showed an increase in polyamine uptake activity and polyamine content in vacuoles.; Remark: alternative name is YOR273c.; Similarity: belongs to the benomyl/methotrexate resistance protein family.; Title: strong similarity to polyamine transport protein Tpo4 - Saccharomyces cerevisiae; See PMID 11171066; See PMID 9593122; uncharacterized protein 229935 4978594 An02g01100 Aspergillus niger uncharacterized protein XP_001399249.3 228062 D 5061 CDS An02g01110 4978595 complement(join(230438..230902,230983..231348,231411..231452)) IV 1 NT_166519.1 Remark: AiiA Bacillus sp., is an enzyme that inactivates the acylhomoserine lactone quorum-sensing signal and attenuates the virulence of Erwinia carotovora.; Title: similarity to metallohydrolase aiiA -Bacillus sp.; See PMID 10716724; uncharacterized protein 231452 4978595 An02g01110 Aspergillus niger uncharacterized protein XP_059605988.1 230438 R 5061 CDS An02g01120 4978596 complement(join(231646..231699,231835..231906,232487..232515,232707..232826,232928..232988,233050..233299,233397..233902)) IV 1 NT_166519.1 Title: weak similarity to hypothetical protein encoded by An18g01500 - Aspergillus niger; uncharacterized protein 233902 4978596 An02g01120 Aspergillus niger uncharacterized protein XP_059605989.1 231646 R 5061 CDS An02g01130 4978597 join(234255..235276,235372..235570) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein encoded by An13g03430 - Aspergillus niger; uncharacterized protein 235570 4978597 An02g01130 Aspergillus niger uncharacterized protein XP_001399252.1 234255 D 5061 CDS An02g01140 4978598 complement(join(235874..236348,236405..236637,236704..237129,237183..237499,237552..238030,238097..238197,238276..238389,238433..238465)) IV 1 NT_166519.1 Similarity: belongs to the unassigned GAL4-type zinc cluster proteins.; Title: weak similarity to acetate regulatory DNA binding protein facB - Aspergillus niger; See PMID 9197408; uncharacterized protein 238465 4978598 An02g01140 Aspergillus niger uncharacterized protein XP_059605990.1 235874 R 5061 CDS An02g01150 84590212 complement(join(238839..238982,239041..239176,239312..239445,239674..239826)) IV 1 NT_166519.1 hypothetical protein 239826 84590212 An02g01150 Aspergillus niger hypothetical protein XP_059605991.1 238839 R 5061 CDS An02g01160 4978600 join(240032..240282,240336..240941,240990..241038) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein encoded by An15g02710 - Aspergillus niger; uncharacterized protein 241038 4978600 An02g01160 Aspergillus niger uncharacterized protein XP_001399255.1 240032 D 5061 CDS An02g01170 84590213 complement(join(241347..241379,241458..241592)) IV 1 NT_166519.1 Remark: the ORF is short in length (55 amino acids).; hypothetical protein 241592 84590213 An02g01170 Aspergillus niger hypothetical protein XP_059605992.1 241347 R 5061 CDS An02g01180 4978602 complement(join(242000..242972,243043..243116)) IV 1 NT_166519.1 Catalytic activity: DPP1 removes the beta phosphate from DGPP (Diacylglycerol pyrophosphate) to form phosphatidate.; Remark: alternative name is YDR284C.; Remark: the DPP1 gene, encoding diacylglycerol pyrophosphate (DGPP) phosphatase from S. cerevisiae, has been identified as a zinc-regulated gene, and it contains a putative zinc-responsive element (UAS(ZRE)) in its promoter.; Similarity: to the PAP2 superfamily.; Title: similarity to diacylglycerol pyrophosphate phosphatase Dpp1 - Saccharomyces cerevisiae; See PMID 9452443; See PMID 11139591; uncharacterized protein 243116 4978602 An02g01180 Aspergillus niger uncharacterized protein XP_001399257.3 242000 R 5061 CDS An02g01190 84590214 complement(join(243242..243431,243638..243686,243868..243970,244056..244149,244296..244591,244743..244769)) IV 1 NT_166519.1 hypothetical protein 244769 84590214 An02g01190 Aspergillus niger hypothetical protein XP_059605993.1 243242 R 5061 CDS An02g01200 4978604 complement(join(245088..245264,245319..246883,246940..247071,247432..247764,247819..247960,248015..248032)) IV 1 NT_166519.1 Remark: loss of KLPA function redresses unbalanced forces within the spindle caused by mutation in bimC, and KLPA and BIMC kinesin-like proteins play opposing roles in spindle function.; Similarity: to kinesin-related protein KLPA.; Title: strong similarity to kinesin-related protein kLPA - Aspergillus nidulans; See PMID 8416986; uncharacterized protein 248032 4978604 An02g01200 Aspergillus niger uncharacterized protein XP_001399259.3 245088 R 5061 CDS An02g01210 4978605 join(248808..249041,249107..249249,249305..249353,249428..249531,249596..250057,250107..250815,250871..251068) IV 1 NT_166519.1 Function: CRN1 of S. cerevisiae is involved in microtubuli filament assembly by promoting the rapid barbed-end assembly of actin filaments and cross-linking filaments into bundles and more complex networks.; Remark: coronin and the ORF show sequence similarities to G protein beta subunits (WD40 repeats).; Remark: the systematic name for CRN1 of S. cerevisiae is YLR429W.; Title: strong similarity to coronin Crn1 -Saccharomyces cerevisiae; See PMID 9885246; uncharacterized protein 251068 4978605 An02g01210 Aspergillus niger uncharacterized protein XP_059605994.1 248808 D 5061 CDS An02g01220 4978606 complement(join(252052..253078,253147..254176,254244..254526,254581..254969,255032..255141,255222..255265)) IV 1 NT_166519.1 Function: U1 snRNP 70K mediated the splicing of pre-mRNA by binding to the stem loop I region of U1-snRNA.; Similarity: the arginine/asparagine-rich C-terminus of the ORF shows similarity to C-terminal sequences in splicing factors, but not to RNA-binding domains.; Title: strong similarity to U1 snRNP 70K protein -Xenopus laevis; uncharacterized protein 255265 4978606 An02g01220 Aspergillus niger uncharacterized protein XP_059605995.1 252052 R 5061 CDS An02g01230 84590215 join(256764..256804,256972..257026,257136..257401,257469..257637) IV 1 NT_166519.1 Remark: the predicted ORF contains an relatively long intron.; hypothetical protein 257637 84590215 An02g01230 Aspergillus niger hypothetical protein XP_059605996.1 256764 D 5061 CDS An02g01240 4978608 join(257780..258404,258481..258743) IV 1 NT_166519.1 Function: negative co-factor 2 (NC2) of H. sapiens regulates transcription of the class II genes through binding to TFIID and inhibition of pre-initiation complex formation by interacting with TBP-promoter complexes via heterodimeric histone fold domains.; Similarity: the C-terminal half of the ORF shows similarity to the N-terminal half of NC2 of H. sapiens.; Title: strong similarity to alpha chain of transcription regulator NC2 - Homo sapiens; uncharacterized protein 258743 4978608 An02g01240 Aspergillus niger uncharacterized protein XP_001399263.1 257780 D 5061 CDS An02g01250 4978609 complement(join(260391..261915,261971..262192,262256..262941,263006..263113,263169..263177)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein encoded by 5E6.080 - Neurospora crassa; uncharacterized protein 263177 4978609 An02g01250 Aspergillus niger uncharacterized protein XP_001399264.1 260391 R 5061 CDS An02g01255 4978610 complement(join(263538..263752,263840..263944,264038..264322,264381..264642)) IV 1 NT_166519.1 hypothetical protein 264642 4978610 An02g01255 Aspergillus niger hypothetical protein XP_059605997.1 263538 R 5061 CDS An02g01260 4978611 join(265454..267313,267366..269720) IV 1 NT_166519.1 Function: het-e mediates vegetative incompatibility in the fungus P. anserina.; Similarity: the similarity of the ORF to het-e of P. anserina does not include the GTP-binding region or WD repeats.; Title: weak similarity to beta transducin-like protein het-e1 - Podospora anserina; uncharacterized protein 269720 4978611 An02g01260 Aspergillus niger uncharacterized protein XP_001399266.1 265454 D 5061 CDS An02g01270 4978612 complement(join(270157..270904,270974..271216,271285..271463,271916..272852,272927..273173,273320..273698)) IV 1 NT_166519.1 Similarity: the aligment is restricted to the inner part of the S. pombe protein and the C-terminus of the predicted ORF.; Title: similarity to hypothetical protein SPAC1783.02c - Schizosaccharomyces pombe; uncharacterized protein 273698 4978612 An02g01270 Aspergillus niger uncharacterized protein XP_059605998.1 270157 R 5061 CDS An02g01280 84590216 join(274817..274825,274909..274944,274996..275058) IV 1 NT_166519.1 Remark: the predicted ORF is only 35 amino acids long.; Title: questionable ORF; uncharacterized protein 275058 84590216 An02g01280 Aspergillus niger uncharacterized protein XP_059605999.1 274817 D 5061 CDS An02g01290 4978614 complement(join(275752..276299,276363..277878)) IV 1 NT_166519.1 Function: PRR1 of S. cerevisiae is involved in pheromone-induced growth arrest, probably by inhibiting gene transcription in pheromone signaling.; Remark: the systematic name for PRR1 of S. cerevisiae is YKL116C.; Similarity: the ORF shows similarity to several unspecified serine/threonine-specific protein kinases from different species.; Title: strong similarity to protein kinase Prr1 -Saccharomyces cerevisiae; See PMID 11337509; uncharacterized protein 277878 4978614 An02g01290 Aspergillus niger uncharacterized protein XP_001399269.1 275752 R 5061 CDS An02g01300 4978615 complement(join(280233..280763,281283..281553,281611..281858)) IV 1 NT_166519.1 Remark: the predcited ORF contains an relatively long intron.; Title: strong similarity to hypothetical protein encoded by An12g03010 - Aspergillus niger; uncharacterized protein 281858 4978615 An02g01300 Aspergillus niger uncharacterized protein XP_059606000.1 280233 R 5061 CDS An02g01310 84590217 complement(join(283331..283509,283610..283781,283867..283983,284247..284306)) IV 1 NT_166519.1 Title: weak similarity to outer membrane protein A precursor ompA - Shigella dysenteriae; uncharacterized protein 284306 84590217 An02g01310 Aspergillus niger uncharacterized protein XP_059606001.1 283331 R 5061 CDS An02g01320 4978617 284398..284886 IV 1 NT_166519.1 Remark: blast matches are not significant.; Title: weak similarity to hypothetical protein encoded by An03g06340 - Aspergillus niger; uncharacterized protein 284886 4978617 An02g01320 Aspergillus niger uncharacterized protein XP_001399272.1 284398 D 5061 CDS An02g01330 4978618 join(285609..285773,285831..286931) IV 1 NT_166519.1 Similarity: shows similarity to several hypothetical NADH-dependent flavin oxidoreductases.; Title: similarity to hypothetical nadh-dependent flavin oxidoreductase SPBC23G7.10c - Schizosaccharomyces pombe; uncharacterized protein 286931 4978618 An02g01330 Aspergillus niger uncharacterized protein XP_001399273.1 285609 D 5061 CDS An02g01340 84590218 complement(join(287177..287284,287343..287539,287613..287976)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein encoded by An16g06660 - Aspergillus niger; uncharacterized protein 287976 84590218 An02g01340 Aspergillus niger uncharacterized protein XP_059606002.1 287177 R 5061 CDS An02g01350 4978620 join(289369..289459,289580..292053) IV 1 NT_166519.1 Function: human ankyrin is a protein linker between the integral membrane proteins and spectrin-based cytoskeleton.; Similarity: human ankyrin is C-terminal 1000 aa longer.; Title: similarity to ankyrin - Homo sapiens; cytoskeleton; See PMID 2137557; See PMID 11018513; uncharacterized protein 292053 4978620 An02g01350 Aspergillus niger uncharacterized protein XP_059606003.1 289369 D 5061 CDS An02g01360 4978621 complement(join(292458..292625,292739..293323)) IV 1 NT_166519.1 Complex: in yeast the preprotein import machinery of the inner membrane (MIM complex) consists of MIM23, MIM17,MIM33 and MIM14.; Function: the yeast MIM complex constitutes a proteinaceous channel that accepts preproteins from the MOM complex, facilitates their reversible transmembrane movement, and mediates unidirectional transport by linkage to the ATP-dependent mt-Hsp70-MIM44 system.; Title: strong similarity to subunit of the mitochondrial inner membrane protein import machinery Mim23 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 7600576; uncharacterized protein 293323 4978621 An02g01360 Aspergillus niger uncharacterized protein XP_059606004.1 292458 R 5061 CDS An02g01370 4978622 join(293920..294023,294115..295040,295094..296039,296087..296323,296371..296599,296648..296958,297007..297524,297575..297715,297762..298384,298437..299258) IV 1 NT_166519.1 Title: strong similarity to hypothetical transmembran protein SPCC1494.07 - Schizosaccharomyces pombe; uncharacterized protein 299258 4978622 An02g01370 Aspergillus niger uncharacterized protein XP_001399277.3 293920 D 5061 CDS An02g01380 84590219 299607..300395 IV 1 NT_166519.1 Similarity: predicted protein has prolin repeats and therefore shows unspecific similarity to various prolin rich proteins.; hypothetical protein 300395 84590219 An02g01380 Aspergillus niger hypothetical protein XP_059606005.1 299607 D 5061 CDS An02g01390 4978624 join(300697..300787,300851..301131,301186..301452,301505..302665,302719..302814) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein SPBC14F5.11c - Schizosaccharomyces pombe; uncharacterized protein 302814 4978624 An02g01390 Aspergillus niger uncharacterized protein XP_001399279.1 300697 D 5061 CDS An02g01400 4978625 join(303641..304686,304797..304972,305055..305083,305140..305195,305246..305252) IV 1 NT_166519.1 Function: ABN A from A. niger endohydrolyses 1,5-alpha-L-arabinofuranosidic linkages in 1,5-arabinanse; Similarity: predicted protein is C-terminal 80 aa longer than all homologies, but no later Startcodon was found.; Title: similarity to endo-alpha-1,5-arabinanase abnA - Aspergillus niger; See PMID 7764386; uncharacterized protein 305252 4978625 An02g01400 Aspergillus niger uncharacterized protein XP_059606006.1 303641 D 5061 CDS An02g01410 84590220 complement(join(305399..305444,305477..306177)) IV 1 NT_166519.1 Similarity: shows unspecific similarity to proteins with serine repeats.; hypothetical protein 306177 84590220 An02g01410 Aspergillus niger hypothetical protein XP_059606007.1 305399 R 5061 CDS An02g01420 4978627 complement(join(307040..307812,307863..308532,308584..309944,309997..312015,312428..312590)) IV 1 NT_166519.1 Catalytic activity: mouse unp converts ubiquitin c-terminal thiolester + h(2)o = ubiquitin + a thiol.; Function: the M. musculus homolog Unp is a de-ubiquitinating enzyme,being able to cleave ubiquitin from both natural and engineered linear ubiquitin-protein fusions, including the polyubiquitin precursor.; Similarity: all similar proteins are at least 500 aa shorter.; Title: similarity to ubiquitin specific protease Unp - Mus musculus; See PMID 9602026; See PMID 11018721; uncharacterized protein 312590 4978627 An02g01420 Aspergillus niger uncharacterized protein XP_059606008.1 307040 R 5061 CDS An02g01430 4978628 join(314363..314393,314454..314969,315043..315701) IV 1 NT_166519.1 Function: AWI 31 form A. thaliana is induced upon wounding.; Title: similarity to induced upon wounding stress protein AWI 31 - Arabidopsis thaliana; See PMID 9085278; uncharacterized protein 315701 4978628 An02g01430 Aspergillus niger uncharacterized protein XP_001399283.1 314363 D 5061 CDS An02g01440 84590221 complement(join(315891..315917,316047..316065,316117..316499)) IV 1 NT_166519.1 hypothetical protein 316499 84590221 An02g01440 Aspergillus niger hypothetical protein XP_059606009.1 315891 R 5061 CDS An02g01450 84590222 join(320348..320648,320859..321103) IV 1 NT_166519.1 hypothetical protein 321103 84590222 An02g01450 Aspergillus niger hypothetical protein XP_059606010.1 320348 D 5061 CDS An02g01460 84590223 join(323120..323203,323236..323243,323324..323378) IV 1 NT_166519.1 Title: questionable ORF; uncharacterized protein 323378 84590223 An02g01460 Aspergillus niger uncharacterized protein XP_059606011.1 323120 D 5061 CDS An02g01470 4978632 complement(join(323645..323784,323909..324314,324421..325016,325186..325217,325369..325430,325533..325545,325623..325776,325883..325940)) IV 1 NT_166519.1 Similarity: shows weak similarity to several DNA-binding zinc-finger proteins due to serine and glutamic acid repeats.; Title: weak similarity to C2H2 zinc finger transcription factor D-Sp1 - Drosophila melanogaster; uncharacterized protein 325940 4978632 An02g01470 Aspergillus niger uncharacterized protein XP_001399287.3 323645 R 5061 CDS An02g01480 4978633 join(328182..329655,329711..329755,329821..330131) IV 1 NT_166519.1 Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; plasma membrane; See PMID 10943556; See PMID 11065353; uncharacterized protein 330131 4978633 An02g01480 Aspergillus niger uncharacterized protein XP_001399288.1 328182 D 5061 CDS An02g01490 4978634 join(331796..332170,332270..332332,332412..332545,332824..333085) IV 1 NT_166519.1 Catalytic activity: human Pcd converts (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7, 8-tetrahydro-4a-hydroxypterin <=> (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pter in + H(2)O.; Function: the human Pcd/dimerization cofactor for the transcription factor HNF-1 alpha is a bifunctional protein proposed to be involved in entirely different biochemical functions.; Title: weak similarity to pterin-4-alpha-carbinolamine dehydratase Pcd - Homo sapiens; See PMID 7763270; uncharacterized protein 333085 4978634 An02g01490 Aspergillus niger uncharacterized protein XP_001399289.3 331796 D 5061 CDS An02g01500 4978635 334256..336673 IV 1 NT_166519.1 Similarity: shows unspecific similarity to maize extensin and murin mucin due to serine and proline repeats.; Title: similarity to hypothetical protein B2E7.150 -Neurospora crassa; uncharacterized protein 336673 4978635 An02g01500 Aspergillus niger uncharacterized protein XP_001399290.1 334256 D 5061 CDS An02g01510 4978636 complement(join(337354..337561,337705..337743,338084..338241,338301..338857,338919..339354)) IV 1 NT_166519.1 Complex: Sec62p from S. cerevisiea is part of the oligomeric Sec-protein complex in the endoplasmic reticulum membrane.; Function: Sec62p from S. cerevisiea is an essential component of the Sec-complex that is responsible for posttranslational protein translocation across the membrane of the endoplasmic reticulum.; Remark: Sec62p from S. cerevisiea binds via its cytosolic N- and C-terminal domains to the Sec-complex.; Title: strong similarity to component of the endoplasmic reticulum protein translocation machinery Sec62 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 11071912; uncharacterized protein 339354 4978636 An02g01510 Aspergillus niger uncharacterized protein XP_001399291.3 337354 R 5061 CDS An02g01520 4978637 join(339787..339846,339911..341695) IV 1 NT_166519.1 Similarity: the weakly similar glucan 1,4-alpha-glucosidase from S. cerevisiae is classified as EC 3. 2. 1. 3.; Title: strong similarity to hypothetical protein YHR151c - Saccharomyces cerevisiae; uncharacterized protein 341695 4978637 An02g01520 Aspergillus niger uncharacterized protein XP_059606012.1 339787 D 5061 CDS An02g01530 4978638 complement(join(342047..343816,343854..344045,344115..344294)) IV 1 NT_166519.1 Remark: the ORF is shorter than the replicase protein of Turnip yellow mosaic virus (713 compared to 1844 amino acids), the alignment between the two proteins encompasses only about 150 amino acids.; Title: similarity to hypothetical replicase protein - Turnip yellow mosaic virus; See PMID 2800335; uncharacterized protein 344294 4978638 An02g01530 Aspergillus niger uncharacterized protein XP_059606013.1 342047 R 5061 CDS An02g01540 4978639 join(344758..345063,345128..345562,345622..346438,346526..346542) IV 1 NT_166519.1 Function: human ferrodoxin-NADP+ oxidoreductase is a flavoprotein mediating electron transport to all mitochondrial forms of cytochrome P450.; Function: plant ferredoxin-NADP+ (oxido)reductase catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin.; Remark: in mammals Adrenodoxin reductase is synonymous for FNR.; Title: strong similarity to ferredoxin-NADP+ reductase FNR - Homo sapiens; localisation:mitochondrion; See PMID 2236061; See PMID 9039955; See PMID 10899784; uncharacterized protein 346542 4978639 An02g01540 Aspergillus niger uncharacterized protein XP_001399294.3 344758 D 5061 CDS An02g01550 4978640 complement(346786..347235) IV 1 NT_166519.1 Function: CS-Ag from C. immitis is a heat-stable,19-kDa antigen with serine protease activity.; Title: strong similarity to secreted serine protease 19 kDa CS antigen CS-Ag - Coccidioides immitis; See PMID 7558310; uncharacterized protein 347235 4978640 An02g01550 Aspergillus niger uncharacterized protein XP_001399295.1 346786 R 5061 CDS An02g01560 4978641 join(350679..351248,351310..351993) IV 1 NT_166519.1 Function: human Edg-4 is a functional G protein-coupled receptor for lysophosphatidic acid (LPA).; Title: weak similarity to G protein-coupled receptor Edg-4 - Homo sapiens; See PMID 9525886; uncharacterized protein 351993 4978641 An02g01560 Aspergillus niger uncharacterized protein XP_001399296.1 350679 D 5061 CDS An02g01570 4978642 complement(join(356217..358418,358769..359206)) IV 1 NT_166519.1 Remark: N-terminal 300 aa longer than most similar predicted ORFs.; Title: strong similarity to hypothetical protein B1D1.130 - Neurospora crassa; uncharacterized protein 359206 4978642 An02g01570 Aspergillus niger uncharacterized protein XP_001399297.3 356217 R 5061 CDS An02g01580 4978643 join(359634..359801,359870..360171,360229..360403,360457..360696) IV 1 NT_166519.1 Function: SNAP proteins activate and recycle SNARE proteins by serving as adaptors between SNAREs and the cytosolic chaperone NSF.; Function: SNAP proteins play an essential role in membrane trafficking in eukaryotic cells.; Similarity: SEC17 from P. pastoris belongs to the SNAP protein family.; Title: strong similarity to vesicular transport protein SEC17 - Pichia pastoris; intracellular transport vesicles; See PMID 9693958; See PMID 10445030; See PMID 10923020; uncharacterized protein 360696 4978643 An02g01580 Aspergillus niger uncharacterized protein XP_059606014.1 359634 D 5061 CDS An02g01590 4978644 complement(join(361453..363282,363345..363814,363886..363997)) IV 1 NT_166519.1 Similarity: the predicted A. niger protein shows strong similarity to conserved hypothetical proteins from diverse eucaryotic species. conservation of the protein sequences among fungal species is particularily strong.; Title: strong similarity to hypothetical protein B5O22.240 - Neurospora crassa; uncharacterized protein 363997 4978644 An02g01590 Aspergillus niger uncharacterized protein XP_001399299.1 361453 R 5061 CDS An02g01600 4978645 join(364383..365015,365073..366047) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein B5O22.250 - Neurospora crassa; See PMID 9545376; uncharacterized protein 366047 4978645 An02g01600 Aspergillus niger uncharacterized protein XP_001399300.1 364383 D 5061 CDS An02g01610 4978646 complement(join(366437..366980,367067..367165,367229..367401)) IV 1 NT_166519.1 Catalytic activity: Klebsiella aerogenes UreG is a GTPase.; Complex: in Klebsiella aerogenes UreG forms a complex containing urease apoprotein and the UreD, and UreF accessory proteins.; Function: Eu3 from G. max is necessary for accumulation of the embryo-specific urease Eu1, perhaps by stabilizing it by Ni insertion and activation of the tissue-ubiquitous urease Eu4.; Remark: Eu3 is synonymous to UreG.; Title: strong similarity to nickel-binding urease accessory protein Eu3 - Glycine max; See PMID 10500143; See PMID 10652150; uncharacterized protein 367401 4978646 An02g01610 Aspergillus niger uncharacterized protein XP_001399301.1 366437 R 5061 CDS An02g01615 84590224 367818..368039 IV 1 NT_166519.1 hypothetical protein 368039 84590224 An02g01615 Aspergillus niger hypothetical protein XP_059606015.1 367818 D 5061 CDS An02g01620 4978648 complement(join(368184..368717,368775..369044,369104..369397,369465..370276,370422..370725)) IV 1 NT_166519.1 Remark: the matching protein ptaB from Aspergillus nidulans is probably involved in regulation of transcription.; Similarity: shows unspecific similarity to several glutamine rich proteins.; Title: similarity to ptaB - Aspergillus nidulans; See PMID 11309119; uncharacterized protein 370725 4978648 An02g01620 Aspergillus niger uncharacterized protein XP_001399303.3 368184 R 5061 CDS An02g01630 4978649 join(372462..372655,372866..372969,373077..375928) IV 1 NT_166519.1 Function: AAA proteases are a conserved class of ATP-dependent proteases that mediate the degradation of membrane proteins in bacteria, mitochondria and chloroplasts.; Function: AAA proteases combine proteolytic and chaperone-like activities and thus form a membrane-integrated quality-control system.; Function: inactivation of AAA proteases causes severe defects in various organisms, including neurodegeneration in humans.; Title: similarity to spastin protein Spast - Homo sapiens; See PMID 10610178; See PMID 10782097; uncharacterized protein 375928 4978649 An02g01630 Aspergillus niger uncharacterized protein XP_059606016.1 372462 D 5061 CDS An02g01640 4978650 join(376586..377759,377930..378398,378485..378503) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein EAA58646.1 - Aspergillus nidulans; uncharacterized protein 378503 4978650 An02g01640 Aspergillus niger uncharacterized protein XP_001399305.3 376586 D 5061 CDS An02g01650 4978651 complement(join(378986..386159,386282..386511)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein B8B20.20 - Neurospora crassa; uncharacterized protein 386511 4978651 An02g01650 Aspergillus niger uncharacterized protein XP_001399306.3 378986 R 5061 CDS An02g01660 84590225 join(388639..388817,388930..389023,389136..389492) IV 1 NT_166519.1 Title: weak similarity to hypothetical AP2 domain transcription factor-like protein MPE11.5 - Arabidopsis thaliana; uncharacterized protein 389492 84590225 An02g01660 Aspergillus niger uncharacterized protein XP_059606017.1 388639 D 5061 CDS An02g01670 84590226 complement(join(389496..389556,389667..390064)) IV 1 NT_166519.1 hypothetical protein 390064 84590226 An02g01670 Aspergillus niger hypothetical protein XP_059606018.1 389496 R 5061 CDS An02g01680 4978654 join(390673..391943,392116..392227) IV 1 NT_166519.1 Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942; uncharacterized protein 392227 4978654 An02g01680 Aspergillus niger uncharacterized protein XP_001399309.3 390673 D 5061 CDS An02g01690 4978655 complement(join(392435..392479,392535..392833,392885..395654,395710..395943,395998..396103,396161..396277,396354..396562)) IV 1 NT_166519.1 Complex: COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex, and the protein Sar1.; Function: Sec31 is the 150 kDa component of the COPII coat, that covers ER-derived vesicles involved in transport from the Endoplasmic Reticulum to the Golgi Apparatus.; Remark: alternate names for S. cerevisiae Sec31: Web1 or YDL195W.; Title: strong similarity to p150 component of the COPII coat of secretory pathway vesicles Sec31 -Saccharomyces cerevisiae; intracellular transport vesicles; See PMID 11210564; See PMID 9190202; uncharacterized protein 396562 4978655 An02g01690 Aspergillus niger uncharacterized protein XP_001399310.1 392435 R 5061 CDS An02g01700 4978656 join(397048..397368,397430..397567) IV 1 NT_166519.1 Similarity: the similarity of the ORF encoded protein to the human RNA binding cyclophilin-33B only concerns the RNA binding domain, there are no similarities to the peptidylprolyl isomerase part of CYP-33.; Title: similarity to RNA binding cyclophilin-33B CYP-33 - Homo sapiens; See PMID 8977107; uncharacterized protein 397567 4978656 An02g01700 Aspergillus niger uncharacterized protein XP_001399311.1 397048 D 5061 CDS An02g01710 4978657 complement(join(397857..397956,398174..398246,398428..>398611)) IV 1 NT_166519.1 Remark: the ORF is truncated due to the border of contig.; Title: weak similarity to hypothetical protein CAD70407.1 - Neurospora crassa [truncated ORF]; uncharacterized protein 398611 4978657 An02g01710 Aspergillus niger uncharacterized protein XP_059606019.1 397857 R 5061 CDS An02g01720 4978658 join(398800..398866,399038..399068,399154..399235,399312..399375,399447..399481) IV 1 NT_166519.1 Catalytic activity: 4 ferrocytochrome c + O(2) <=> 4 ferricytochrome c + 2 H(2)O (catalyzed by the complete complex).; Function: the S. cerevisiae Cox12 protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. It is essential during assembly of the cytochrome c oxidase complex for its full activity but apparently can be removed after the oxidase is assembled.; Remark: alternate name for S. cerevisiae Cox12: YLR038C.; Title: strong similarity to subunit VIb of cytochrome c oxidase Cox12 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 1331057; uncharacterized protein 399481 4978658 An02g01720 Aspergillus niger uncharacterized protein XP_059599883.1 398800 D 5061 CDS An02g01730 4978659 complement(join(400902..401585,401656..401754,401873..401877,401949..402102)) IV 1 NT_166519.1 Function: the S. cerevisiae dicarboxylate transport protein DTP catalyzes an electroneutral exchange across the inner mitochondrial membrane of dicarboxylates (e. g. malonate, malate, succinate) for inorganic phosphate and certain sulfur-containing compounds (e. g. sulfite, sulfate, thiosulfate) (TC 2. A. 29).; Remark: alternate names for S. cerevisiae DTP: DIC1 or YLR348c.; Title: strong similarity to mitochondrial dicarboxylate transport protein Dtp - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9020177; uncharacterized protein 402102 4978659 An02g01730 Aspergillus niger uncharacterized protein XP_001399314.3 400902 R 5061 CDS An02g01740 4978660 complement(402842..404386) IV 1 NT_166519.1 Catalytic activity: ATP + L-phenylalanine + tRNA(Phe) <=> AMP + diphosphate + L-phenylalanyl-tRNA(Phe).; Remark: alternate name for S. cerevisiae Msf1: YPR047W.; Remark: in contrast to the cytosolic protein, the mitochondrial phenylalanine--tRNA ligase is active as monomer.; Title: strong similarity to mitochondrial phenylalanine--tRNA ligase alpha subunit Msf1 -Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 1924298; See PMID 3029120; uncharacterized protein 404386 4978660 An02g01740 Aspergillus niger uncharacterized protein XP_001399315.1 402842 R 5061 CDS An02g01750 4978661 complement(join(405180..405209,405271..405699,405799..406062)) IV 1 NT_166519.1 Function: S. cerevisiae Mge1 cooperates with mitochondrial Hsp70 (Ssc1) in the mitochondrial import of proteins from the cytoplasm. It seems to control the nucleotide-dependent binding of Ssc1 to substrate proteins and the association of Ssc1 with Mim44.; Localization: S. cerevisiae Mge1 is localized in the mitochondrial matrix.; Remark: alternate names for S. cerevisiae Mge1: Yge1 or YOR232W.; Similarity: S. cerevisiae Mge1 belongs to the GrpE family.; Title: strong similarity to chaperone involved in mitochondrial protein import Mge1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9048947; See PMID 8022808; See PMID 8798629; uncharacterized protein 406062 4978661 An02g01750 Aspergillus niger uncharacterized protein XP_001399316.1 405180 R 5061 CDS An02g01760 4978662 join(409242..409823,409857..410141) IV 1 NT_166519.1 Complex: CBP1 from Cryptococcus neoformans binds to calcineurin in vitro and in vivo.; Function: Cryptococcus neoformans cbp1 mutant strains exhibit modest defects in growth under stress conditions and virulence.; Remark: Cryptococcus neoformans = Filobasidiella neoformans.; Similarity: the ORF encoded protein shows strongest similarity to the nebula related protein from Neurospora crassa (B5O22. 230) which is functionally not characterized.; Title: similarity to calcineurin-binding protein CBP1 - Cryptococcus neoformans; See PMID 10899116; uncharacterized protein 410141 4978662 An02g01760 Aspergillus niger uncharacterized protein XP_059599884.1 409242 D 5061 CDS An02g01770 4978663 complement(join(410794..410919,411031..411302,411368..411433,411495..411617,411662..411876,411929..412090,412148..412270,412327..412389,412464..412539,412645..412689,413060..413117)) IV 1 NT_166519.1 Catalytic activity: L-arginyl-tRNA + protein <=> tRNA + L-arginyl-protein.; Function: S. cerevisiae Ate1 functions in the N-end rule pathway of protein degradation, where it conjugates Arg, a primary destabilizing residue, to N-termini of proteins bearing secondary destabilizing residues aspartic acid or glutamic acid.; Remark: alternate name for S. cerevisiae Ate1: YGL017W.; Title: strong similarity to arginyl-tRNA-protein transferase Ate1 - Saccharomyces cerevisiae; See PMID 2185248; uncharacterized protein 413117 4978663 An02g01770 Aspergillus niger uncharacterized protein XP_059599885.1 410794 R 5061 CDS An02g01780 84590227 complement(join(414133..414221,414323..414466,414558..414700,414793..414834,414915..415065,415864..415902,416153..416222,416292..416346,416463..416534,416605..416831,416980..417171,417264..417323,417361..417504,417583..417597)) IV 1 NT_166519.1 hypothetical protein 417597 84590227 An02g01780 Aspergillus niger hypothetical protein XP_059599886.1 414133 R 5061 CDS An02g01790 4978665 join(417755..417806,417951..418378) IV 1 NT_166519.1 Function: S. pombe Aps1 catalyzes the hydrolysis of dinucleoside oligophosphates.; Remark: dinucleoside polyphosphates (Ap3A,1 Ap4A,Ap5A, and Ap6A) are involved in intracellular and extracellular signaling functions in several biological systems.; Similarity: S. pombe Aps1 belongs to the nudix hydrolase family.; Title: strong similarity to diadenosine 5,5-P1,P6-hexaphosphate hydrolase aps1p - Schizosaccharomyces pombe; See PMID 10090752; See PMID 10419486; uncharacterized protein 418378 4978665 An02g01790 Aspergillus niger uncharacterized protein XP_001399320.3 417755 D 5061 CDS An02g01800 4978666 join(419373..419426,419546..420114,420246..420639) IV 1 NT_166519.1 Catalytic activity: N nucleoside triphosphate <=> N diphosphate + {RNA}(N).; Function: S. cerevisiae Rpb3 is a component of the DNA-dependent RNA polymerase II catalyzes the transcription of DNA into mRNA using the four ribonucleoside triphosphates as substrates.; Remark: alternate name for S. cerevisiae Rpb3: YIL021W.; Title: strong similarity to 45 kD subunit of DNA-directed RNA polymerase II Rpb3 - Saccharomyces cerevisiae; nucleus; See PMID 9556554; See PMID 9738888; See PMID 2685562; uncharacterized protein 420639 4978666 An02g01800 Aspergillus niger uncharacterized protein XP_001399321.1 419373 D 5061 CDS An02g01810 4978667 complement(join(422319..423643,423716..424259)) IV 1 NT_166519.1 Title: weak similarity to huntingtin interacting protein 1 related Hip1R - Mus musculus; uncharacterized protein 424259 4978667 An02g01810 Aspergillus niger uncharacterized protein XP_001399322.1 422319 R 5061 CDS An02g01820 84590228 complement(join(426537..426614,426680..426769)) IV 1 NT_166519.1 Title: questionable ORF; uncharacterized protein 426769 84590228 An02g01820 Aspergillus niger uncharacterized protein XP_059599887.1 426537 R 5061 CDS An02g01830 4978669 complement(join(427216..427240,427307..427401,427466..427624,427698..427729,428152..428179)) IV 1 NT_166519.1 Gene-ID: cyc; localisation:mitochondrion; See PMID 2544196; cytochrome c cyc-Aspergillus niger 428179 cyc 4978669 cyc Aspergillus niger cytochrome c cyc-Aspergillus niger XP_001399324.1 427216 R 5061 CDS An02g01840 84590229 join(428280..428433,428535..428581) IV 1 NT_166519.1 hypothetical protein 428581 84590229 An02g01840 Aspergillus niger hypothetical protein XP_059599888.1 428280 D 5061 CDS An02g01850 84590230 complement(join(428670..428713,428794..428988,429168..429222)) IV 1 NT_166519.1 hypothetical protein 429222 84590230 An02g01850 Aspergillus niger hypothetical protein XP_059599889.1 428670 R 5061 CDS An02g01860 4978672 join(429274..429660,429752..430152,430273..430624) IV 1 NT_166519.1 Title: similarity to hypothetical protein CAD21170.1 - Neurospora crassa; uncharacterized protein 430624 4978672 An02g01860 Aspergillus niger uncharacterized protein XP_059599890.1 429274 D 5061 CDS An02g01870 4978673 join(431235..431337,431407..431876) IV 1 NT_166519.1 Function: the peripheral-type benzodiazepine receptor from mouse is responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. It may play a role in the transport of porphyrins and heme.; Title: strong similarity to peripheral-type benzodiazepine receptor 1 isoquinoline-binding protein MBR - Mus musculus; localisation:mitochondrion; See PMID 8125973; uncharacterized protein 431876 4978673 An02g01870 Aspergillus niger uncharacterized protein XP_001399328.1 431235 D 5061 CDS An02g01880 4978674 join(432782..432830,433001..433629) IV 1 NT_166519.1 Similarity: the similarities of the ORF encoded protein are mainly based on repetitive structures.; Title: weak similarity to hypothetical protein AAH29548.1 - Mus musculus; uncharacterized protein 433629 4978674 An02g01880 Aspergillus niger uncharacterized protein XP_001399329.3 432782 D 5061 CDS An02g01890 4978675 complement(join(433914..434968,435026..435128,435183..435977)) IV 1 NT_166519.1 Similarity: the similarities of the ORF encoded protein to all matching proteins are based on repetitive structures.; Title: weak similarity to hydroxyproline-rich cell wall glycoprotein HRGPnt3 - Nicotiana tabacum; uncharacterized protein 435977 4978675 An02g01890 Aspergillus niger uncharacterized protein XP_001399330.1 433914 R 5061 CDS An02g01900 4978676 complement(join(437144..437257,437322..437714,437912..438146,438213..438239,438292..438365)) IV 1 NT_166519.1 Title: similarity to hypothetical protein SPBP8B7.28c - Schizosaccharomyces pombe; uncharacterized protein 438365 4978676 An02g01900 Aspergillus niger uncharacterized protein XP_059599891.1 437144 R 5061 CDS An02g01910 84590231 join(438442..438548,438631..438715) IV 1 NT_166519.1 hypothetical protein 438715 84590231 An02g01910 Aspergillus niger hypothetical protein XP_059599892.1 438442 D 5061 CDS An02g01920 84590232 complement(join(442062..442296,442532..443072,443161..443194)) IV 1 NT_166519.1 hypothetical protein 443194 84590232 An02g01920 Aspergillus niger hypothetical protein XP_059599893.1 442062 R 5061 CDS An02g01930 84590233 complement(join(443378..443512,443598..443813)) IV 1 NT_166519.1 hypothetical protein 443813 84590233 An02g01930 Aspergillus niger hypothetical protein XP_059599894.1 443378 R 5061 CDS An02g01940 84590234 complement(join(444521..444826,444898..445167,445219..445261,445343..445454,445566..445705,445817..445881,445975..446073)) IV 1 NT_166519.1 hypothetical protein 446073 84590234 An02g01940 Aspergillus niger hypothetical protein XP_059599895.1 444521 R 5061 CDS An02g01950 4978681 join(446210..446383,446443..447186,447240..448676) IV 1 NT_166519.1 Function: S. cerevisiae Sme1 is an essential for pre-mRNA splicing, cap modification and U1, U2, U4 and U5 snRNA stability.; Remark: alternate name for S. cerevisiae Sme1: YOR159C.; Similarity: the S. cerevisiae Sme1 protein is a human E core protein homolog.; Title: similarity to homolog of the human E core protein Sme1 - Saccharomyces cerevisiae; nucleus; See PMID 8918241; See PMID 9012791; uncharacterized protein 448676 4978681 An02g01950 Aspergillus niger uncharacterized protein XP_001399336.1 446210 D 5061 CDS An02g01960 84590235 complement(join(449003..449094,449191..449224,449314..449368,449663..449742)) IV 1 NT_166519.1 Title: questionable ORF; uncharacterized protein 449742 84590235 An02g01960 Aspergillus niger uncharacterized protein XP_059599896.1 449003 R 5061 CDS An02g01970 4978683 join(450002..450550,450617..451225) IV 1 NT_166519.1 Title: similarity to hypothetical membrane protein YDL111c - Saccharomyces cerevisiae; uncharacterized protein 451225 4978683 An02g01970 Aspergillus niger uncharacterized protein XP_001399338.1 450002 D 5061 CDS An02g01980 4978684 complement(451731..452453) IV 1 NT_166519.1 Function: DRAP-deaminase of A. gossypii converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.; Pathway: DRAP-deaminase of A. gossypii belongs to the riboflavin biosynthesis pathway.; Remark: the patented gene was isolated from an A. gossypii cDNA library and clones were isolated by functional complementation in S. cerevisiae mutants. it can be used for production of riboflavin in eukaryotic cells.; Title: similarity to DRAP-deaminase rib2 from patent DE4420785-A1 - Ashbya gossypii; uncharacterized protein 452453 4978684 An02g01980 Aspergillus niger uncharacterized protein XP_001399339.1 451731 R 5061 CDS An02g01990 4978685 join(452830..453031,453106..453875) IV 1 NT_166519.1 Remark: the DnaJ-like protein HSPJ2 of H. sapiens may be used to treat or prevent tissue damage, e. g. in cases of ankylosing spondylitis, heart attack, ischaemia,UV exposure, insulin-dependent diabetes and for wound healing, and may be expressed from a vector containing the nucleic acids. antagonists of HSPJ2 of H. sapiens are used to treat or prevent a wide variety of solid cancers,leukaemia and lymphoma, immune disorders and inflammation.; Title: similarity to DnaJ-like protein HSPJ2 from patent WO9855509-A2 - Homo sapiens; cytoplasm; uncharacterized protein 453875 4978685 An02g01990 Aspergillus niger uncharacterized protein XP_001399340.1 452830 D 5061 CDS An02g02000 4978686 join(455212..456391,456448..457196,457246..457307,457368..457533) IV 1 NT_166519.1 Remark: the ORF is similar to an EST (AA788334) from A. nidulans.; Similarity: the C-terminus of the ORF is similar to the C-terminus of the hypothetical protein SPAC167. 05 of S. pombe. similarities to other ORFs are due to low complexity of sequence.; Title: strong similarity to hypothetical protein SPAC167.05 - Schizosaccharomyces pombe; uncharacterized protein 457533 4978686 An02g02000 Aspergillus niger uncharacterized protein XP_001399341.1 455212 D 5061 CDS An02g02010 4978687 complement(join(458116..458337,458399..458640,458699..458765,458822..459279,459346..459384,459471..459591)) IV 1 NT_166519.1 Catalytic activity: tyrosyl-tRNA synthetase catalyses ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).; Pathway: the activation of amino acids and transfer to specific tRNA molecules is the first step in protein biosynthesis.; Phenotype: the null mutant of tyrosyl-tRNA synthetase of S. cerevisiae is inviable.; Remark: the tyrosyl-tRNA synthetase gene of S. cerevisiae was isolated by functional complementation of a mutant Escherichia coli suppressor tRNA defective in aminoacylation.; Similarity: the ORF is similar to tyrosyl-tRNA synthetase.; Title: strong similarity to cytoplasmic tyrosine--tRNA ligase Tyrrs - Saccharomyces cerevisiae; cytoplasm; See PMID 8509419; uncharacterized protein 459591 4978687 An02g02010 Aspergillus niger uncharacterized protein XP_001399342.1 458116 R 5061 CDS An02g02020 4978688 join(460568..460666,460753..460837,460904..460923,461005..461040,461093..461254,461305..461621,461669..461943,461991..462209,462258..462568) IV 1 NT_166519.1 Function: V-ATPase of S. cerevisiae is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. it is an electrogenic proton pump that generates a proton motive force of 180 mV, inside positive and acidic, in the vacuolar membrane vesicles. V-ATPase catalyses the reaction ATP + H(2)O = ADP + phosphate.; Phenotype: the null mutant of vma-2 of S. cerevisiae is viable, but severely defective for growth in medium buffered at neutral pH.; Remark: the protein vma-2 of S. cerevisiae is a noncatalytic subunit (B) of the peripheral heteromultimeric V1 complex of vacuolar ATPase (V-ATPase).; Title: strong similarity to vacuolar H(+)-transporting ATPase subunit B Vma2 - Saccharomyces cerevisiae; vacuole; See PMID 9819393; See PMID 10358087; See PMID 2478556; See PMID 8626613; uncharacterized protein 462568 4978688 An02g02020 Aspergillus niger uncharacterized protein XP_001399343.1 460568 D 5061 CDS An02g02030 4978689 complement(join(462756..463392,463483..464231)) IV 1 NT_166519.1 Function: isopenicillin N epimerase of N. lactamdurans catalyzes the reversible isomerization between isopenicillin N and penicillin N and requires pyridoxal phosphate as a cofactor.; Pathway: isopenicillin N epimerase is involved in the biosynthesis of cephalosporin antibiotics.; Remark: expression of cefD of N. lactamdurans in S. lividans transformants results in isopenicillin N epimerase activities that are 10-12 times higher than those in N. lactamdurans.; Remark: the sequence SXHKXL in isopenicillin N epimerase of N. lactamdurans resembles the consensus sequence for pyridoxal phosphate binding found in several amino acid decarboxylases from Enterobacteria.; Similarity: isopenicillin N epimerase of N. lactamdurans belongs to class-V of pyridoxal-phosphate-dependent aminotransferases.; Title: strong similarity to isopenicillin N epimerase cefD - Nocardia lactamdurans; cytoplasm; See PMID 1867773; uncharacterized protein 464231 4978689 An02g02030 Aspergillus niger uncharacterized protein XP_059599897.1 462756 R 5061 CDS An02g02040 4978690 complement(join(464626..464924,464972..468767,468864..469296,469427..469524)) IV 1 NT_166519.1 Similarity: the ORF is similar to various long proteins due to low complexity of sequence.; Title: strong similarity to hypothetical protein SPAC4F10.13c - Schizosaccharomyces pombe; uncharacterized protein 469524 4978690 An02g02040 Aspergillus niger uncharacterized protein XP_059599898.1 464626 R 5061 CDS An02g02050 84590236 join(469560..469622,469710..469936,470199..470214,470300..470478,470597..470647,470816..471037,471126..471311,471420..471501) IV 1 NT_166519.1 hypothetical protein 471501 84590236 An02g02050 Aspergillus niger hypothetical protein XP_059599899.1 469560 D 5061 CDS An02g02060 4978692 join(472614..473423,473483..473779) IV 1 NT_166519.1 Remark: the patented alcohol dehydrogenase is used for the synthesis of coniferyl alcohol, coniferyl aldehyde,ferulic acid, vanillin, vanillic acid and their applications.; Similarity: the protein is similar to alcohol dehydrogenases.; Title: strong similarity to alcohol dehydrogenase from patent EP0845532-A - Unclassified organism; cytoplasm; uncharacterized protein 473779 4978692 An02g02060 Aspergillus niger uncharacterized protein XP_001399347.1 472614 D 5061 CDS An02g02070 4978693 join(474080..474199,474259..474834) IV 1 NT_166519.1 Similarity: ORF has similarity to several coiled-coil proteins.; hypothetical protein 474834 4978693 An02g02070 Aspergillus niger hypothetical protein XP_059599900.1 474080 D 5061 CDS An02g02080 84590237 complement(join(474901..475094,475198..475311,475415..475615,475711..475780)) IV 1 NT_166519.1 hypothetical protein 475780 84590237 An02g02080 Aspergillus niger hypothetical protein XP_059599901.1 474901 R 5061 CDS An02g02090 84590238 join(476098..476175,476687..476851,477128..477193,477280..477447) IV 1 NT_166519.1 hypothetical protein 477447 84590238 An02g02090 Aspergillus niger hypothetical protein XP_059599902.1 476098 D 5061 CDS An02g02100 84590239 join(478886..478946,479077..479110,479198..479316,479368..479441,479536..479632,479729..479808,479874..479965,480056..480161,480248..480413,480491..480561,480643..480700,480754..480890) IV 1 NT_166519.1 hypothetical protein 480890 84590239 An02g02100 Aspergillus niger hypothetical protein XP_059599903.1 478886 D 5061 CDS An02g02110 84590240 complement(join(481695..481823,481866..482189,482369..482396,482435..482541)) IV 1 NT_166519.1 hypothetical protein 482541 84590240 An02g02110 Aspergillus niger hypothetical protein XP_059599904.1 481695 R 5061 CDS An02g02120 84590241 complement(join(482792..482870,482939..483003,483089..483247)) IV 1 NT_166519.1 hypothetical protein 483247 84590241 An02g02120 Aspergillus niger hypothetical protein XP_059599905.1 482792 R 5061 CDS An02g02130 84590242 join(483405..483460,483550..483675,483827..483916,483985..484056,484152..484228,484325..484368,484412..484433,484476..484560,484645..484701,484778..484959,485098..485156) IV 1 NT_166519.1 hypothetical protein 485156 84590242 An02g02130 Aspergillus niger hypothetical protein XP_059599906.1 483405 D 5061 CDS An02g02140 84590243 join(487498..487527,487638..487685,487759..487992,488024..488153,488234..488286) IV 1 NT_166519.1 hypothetical protein 488286 84590243 An02g02140 Aspergillus niger hypothetical protein XP_059599907.1 487498 D 5061 CDS An02g02150 4978701 join(488600..488639,488771..>490005) IV 1 NT_166519.1 Function: Mutations in the developmental modifier medusa (medA) of A. nidulans result in aberrant conidiophores with branching chains of reiterated reproductive cells (metulae), delayed conidial differentiation and frequent reinitiation of secondary conidiophores.; Function: the medusa protein of A. nidulans is required for correct temporal expression of both brlA transcripts (brlA alpha and brlA beta). the medusa protein of A. nidulans is a coactivator required for normal levels of abacus (abaA) expression.; Remark: C-terminus is missing due to truncated ORF.; Title: strong similarity to hypothetical Medusa medA - Aspergillus nidulans [truncated ORF]; See PMID 8722771; uncharacterized protein 490005 4978701 An02g02150 Aspergillus niger uncharacterized protein XP_001399356.3 488600 D 5061 CDS An02g02160 84590244 complement(join(<490147..490297,490332..490484,490526..490590)) IV 1 NT_166519.1 Remark: the ORF is highly similar to ESTs BE759272 and BE759284 of A. niger.; hypothetical protein 490590 84590244 An02g02160 Aspergillus niger hypothetical protein XP_059606020.1 490147 R 5061 CDS An02g02170 4978703 join(491574..491709,491785..492088,492147..493878) IV 1 NT_166519.1 Function: tryptophan synthase TRP5 of S. cerevisiae catalyses the reaction L-serine + 1-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H(2)O. TRP5 also catalyses the conversion of indoleglycerol phosphate into indole and glyceraldehyde phosphate. the enzyme requires the co-factor pyridoxal-phosphate.; Pathway: tryptophan synthase catalyzes the last (fifth) step in the biosynthesis of tryptophan.; Remark: in bacteria and plants, each domain is found on a separate subunit (alpha and beta chains), while in fungi the two domains are fused together on a single multifunctional protein.; Remark: yeast genomic DNA fragments expressed in the yeast shuttle vector pCN60 rescue the trp5 mutation of the yeast cell C9 when they harbor TRP5.; Title: strong similarity to tryptophan synthase Trp5 - Saccharomyces cerevisiae; cytoplasm; See PMID 2675471; See PMID 2734310; See PMID 6276387; uncharacterized protein 493878 4978703 An02g02170 Aspergillus niger uncharacterized protein XP_001399358.1 491574 D 5061 CDS An02g02180 4978704 complement(join(494662..494701,494734..494883,494941..495241,495312..495425,495470..495971,496022..496129)) IV 1 NT_166519.1 Remark: HTRM are human transcriptional regulator molecules. The patent gives no further information about the function of the protein.; Title: similarity to HTRM clone 052927 from patent WO9957144-A2 - Homo sapiens; uncharacterized protein 496129 4978704 An02g02180 Aspergillus niger uncharacterized protein XP_059606021.1 494662 R 5061 CDS An02g02190 4978705 complement(join(496700..497029,497084..497177,497245..497263,497320..497338)) IV 1 NT_166519.1 Function: the protein is a putative transmembrane protein.; Similarity: the protein is similar to patented HRM-7 of H. sapiens and hypothetical proteins from several divergent species.; Title: strong similarity to human regulatory molecule HRM-7 from patent WO9915658-A2 - Homo sapiens; uncharacterized protein 497338 4978705 An02g02190 Aspergillus niger uncharacterized protein XP_001399360.1 496700 R 5061 CDS An02g02200 10098042 join(497870..498051,498107..498280,498397..498629,498799..499006,499452..499671,499745..500293) IV 1 NT_166519.1 Similarity: the ORF contains repetitive proline and threonine residues.; Title: similarity to hypothetical SNF2/SWI2 protein family member SRCAP - Homo sapiens; uncharacterized protein 500293 10098042 An02g02200 Aspergillus niger uncharacterized protein XP_003188604.2 497870 D 5061 CDS An02g02210 4978707 complement(join(500656..501192,501298..503432,503482..504265)) IV 1 NT_166519.1 Function: HLTF of H. sapiens binds to the B Box of the plasminogen activator inhibitor-1 (PAI-1) gene. in vitro transcription from the PAI-1 promoter in HeLa cell extracts was inhibited by HLTF antibodies and by the HLTF DNA binding domain.; Localization: HLTF from H. sapiens was located in the nucleoplasm and can be immunoprecipitated from HeLa cell nuclear extracts.; Similarity: helicase-like transcription factor (HLTF) from H. sapiens contains a DNA-binding domain, a RING finger domain, and seven helicase domains and is homologous to SWI/SNF proteins of S. cerevisiae.; Title: strong similarity to helicase-like transcription factor - Homo sapiens; nucleus; See PMID 8672239; uncharacterized protein 504265 4978707 An02g02210 Aspergillus niger uncharacterized protein XP_059606022.1 500656 R 5061 CDS An02g02220 84590245 join(504279..504415,504467..504638,504723..504815) IV 1 NT_166519.1 hypothetical protein 504815 84590245 An02g02220 Aspergillus niger hypothetical protein XP_059606023.1 504279 D 5061 CDS An02g02230 4978709 complement(join(505213..506079,506140..506343,506395..506597,506685..507636)) IV 1 NT_166519.1 Similarity: the ORF is strongly similar to hypothetical proteins from several divergent species.; Title: strong similarity to hypothetical protein SPAC824.01 - Schizosaccharomyces pombe; uncharacterized protein 507636 4978709 An02g02230 Aspergillus niger uncharacterized protein XP_059606024.1 505213 R 5061 CDS An02g02240 4978710 join(508627..508677,508848..508969,509387..509441,509473..509508,509635..509993,510192..510285,510664..510852,510948..511667) IV 1 NT_166519.1 Function: an Asd-4 null mutant of N. crassa obtained by the rip procedure did not show any effect upon nitrogen control, but instead resulted in severe defects in ascus and ascospore genesis.; Function: mobility shift assays demonstrated that ASD4 acts as a sequence-specific DNA binding protein and recognizes DNA fragments that contain GATA core elements.; Remark: ASD4 protein of N. crassa contains a single GATA-type zinc finger and a putative coiled-coil domain. the ASD4 protein exists as a tetramer in solution.; Title: strong similarity to GATA type zinc finger protein ASD4 - Neurospora crassa; nucleus; See PMID 10998244; uncharacterized protein 511667 4978710 An02g02240 Aspergillus niger uncharacterized protein XP_001399365.3 508627 D 5061 CDS An02g02250 4978711 join(513397..513734,513796..514115,514178..514473,514523..514685,514741..514925) IV 1 NT_166519.1 Function: SRPK2 of H. sapiens is involved in spliceosome assembly for pre-mRNA splicing and the control of trafficking of splicing factors, probably by phosphorylating arginine and serine-rich (RS) domains in respective proteins.; Similarity: the ORF shows similarity to several serine/arginine-rich protein-specific kinases from different species with various cellular fucntions.; Title: strong similarity to serine kinase SRPK2 -Homo sapiens; uncharacterized protein 514925 4978711 An02g02250 Aspergillus niger uncharacterized protein XP_059606025.1 513397 D 5061 CDS An02g02260 4978712 complement(join(515579..516066,516115..516302,516356..516980,517038..517079,517199..517331,517391..517462,517533..517613)) IV 1 NT_166519.1 Title: strong similarity to hypothetical membrane protein YMR155w - Saccharomyces cerevisiae; uncharacterized protein 517613 4978712 An02g02260 Aspergillus niger uncharacterized protein XP_059606026.1 515579 R 5061 CDS An02g02270 4978713 join(518610..518660,518713..518792,518871..519459,519529..520245) IV 1 NT_166519.1 Title: strong similarity to hypothetical membrane protein YDR105c - Saccharomyces cerevisiae; uncharacterized protein 520245 4978713 An02g02270 Aspergillus niger uncharacterized protein XP_001399368.3 518610 D 5061 CDS An02g02280 4978714 join(520683..520818,520896..522360,522919..523927) IV 1 NT_166519.1 Function: PMS1 of S. cerevisiae is a mutL homolog and is similar to and associates with Mlh1p, possibly by forming a heterodimer, that binds to a Msh2p-heteroduplex complex containing a G-T mismatch.; Function: PMS1 of S. cerevisiae is required for DNA mismatch repair in mitosis and meiosis, low levels of postmeiotic segregation, and high spore viability, but is dispensable for homologous recombination.; Phenotype: mutations in the DNA mismatch repair protein PMS1 of S. cerevisiae results in elevated rates of spontaneous mutation and causes a marked increase in the instability of simple DNA repeats.; Remark: PMS1 of S. cerevisiae is also called YNL082W or N2317.; Title: strong similarity to DNA mismatch repair gene Pms1 - Saccharomyces cerevisiae; See PMID 8842147; See PMID 7618086; uncharacterized protein 523927 4978714 An02g02280 Aspergillus niger uncharacterized protein XP_059606027.1 520683 D 5061 CDS An02g02290 4978715 join(524495..524617,524690..524797,524844..526328) IV 1 NT_166519.1 Catalytic activity: delta-1-pyrroline-5-carboxylate dehydrogenases catalyse 1-pyrroline-5-carboxylate + NAD(+) + H(2)O <=> L-glutamate + NADH.; Function: prnC of A. nidulans is involved in the mitochondrial pathway for proline utilization.; Remark: in A. nidulans the genes prnB, prnC, and prnD are clustered.; Repression: prnC of A. nidulans is repressed by the simultaneous presence of glucose and ammonium.; Title: strong similarity to delta-1-pyrroline-5-carboxylate dehydrogenase prnC -Aspergillus nidulans; See PMID 10613888; See PMID 355839; uncharacterized protein 526328 4978715 An02g02290 Aspergillus niger uncharacterized protein XP_001399370.1 524495 D 5061 CDS An02g02300 84590246 join(526831..527083,527256..527584) IV 1 NT_166519.1 Similarity: the ORF shows weak similarity to peptide synthetases from different species, which are all around 1000 amino acids longer.; Title: weak similarity to nonribosomal peptide synthetase tex1 - Hypocrea virens; uncharacterized protein 527584 84590246 An02g02300 Aspergillus niger uncharacterized protein XP_059606028.1 526831 D 5061 CDS An02g02310 4978717 complement(join(528534..528642,528716..529260)) IV 1 NT_166519.1 Function: the human IBSP product binds tightly to hydroxyapatite. It appears to form an integral part of the mineralized matrix. It probably important to cell-matrix interaction and promotes Arg-Gly-Asp-dependent cell attachment.; Title: similarity to bone sialoprotein precursor IBSP - Homo sapiens; extracellular/secretion proteins; See PMID 3597437; uncharacterized protein 529260 4978717 An02g02310 Aspergillus niger uncharacterized protein XP_001399372.3 528534 R 5061 CDS An02g02320 4978718 complement(join(530246..530980,531030..531095)) IV 1 NT_166519.1 Remark: alternate name for S. cerevisiae Upc2: YDR213W.; Similarity: the ORF encoded protein and S. cerevisiae are zinc finger transcription factors of the Zn(2)-Cys(6) binuclear cluster domain type.; Title: similarity to RNA polymerase II transcription factor Upc2 - Saccharomyces cerevisiae; See PMID 9696767; uncharacterized protein 531095 4978718 An02g02320 Aspergillus niger uncharacterized protein XP_001399373.3 530246 R 5061 CDS An02g02330 4978719 join(531446..531617,531692..532347) IV 1 NT_166519.1 Function: S. cerevisiae Rta1 is involved in 7-aminocholesterol resistance.; Remark: alternate name for S. cerevisiae Rta1: YGR213C.; Similarity: the ORF encoded protein and S. cerevisiae are also strong similar to yeast RTM1 and YER185w.; Title: strong similarity to hypothetical 7-aminocholesterol resistance protein Rta1 - Saccharomyces cerevisiae; See PMID 8660468; uncharacterized protein 532347 4978719 An02g02330 Aspergillus niger uncharacterized protein XP_001399374.1 531446 D 5061 CDS An02g02340 4978720 complement(join(532994..533091,533142..534409,534457..538080,538130..538422)) IV 1 NT_166519.1 Catalytic activity: UDP-N-acetyl-D-glucosamine + {(1, 4)-(N-acetyl-beta-D-glucosaminyl)}(N) <=> UDP + {(1,4)-(N-acetyl-beta-D-glucosaminyl)}(N+1).; Remark: CsmA=asmA (PIR:JC5546).; Title: strong similarity to chitin synthase with a myosin motor-like domain csmA - Aspergillus nidulans; See PMID 9223429; See PMID 10368147; uncharacterized protein 538422 4978720 An02g02340 Aspergillus niger uncharacterized protein XP_001399375.1 532994 R 5061 CDS An02g02350 84590247 complement(join(541376..541552,541758..541772)) IV 1 NT_166519.1 hypothetical protein 541772 84590247 An02g02350 Aspergillus niger hypothetical protein XP_059606029.1 541376 R 5061 CDS An02g02360 4978722 join(542477..542589,542646..542834,542878..>547418) IV 1 NT_166519.1 Catalytic activity: UDP-N-acetyl-D-glucosamine + {(1, 4)-(N-acetyl-beta-D-glucosaminyl)}(N) <=> UDP + {(1,4)-(N-acetyl-beta-D-glucosaminyl)}(N+1).; Remark: C-terminally truncated ORF due to the end of contig.; Remark: CsmA=asmA (PIR:JC5546).; Title: strong similarity to chitin synthase with a myosin motor-like domain csmA - Aspergillus nidulans [truncated ORF]; See PMID 9223429; See PMID 10368147; uncharacterized protein 547418 4978722 An02g02360 Aspergillus niger uncharacterized protein XP_059606030.1 542477 D 5061 CDS An02g02370 4978723 complement(join(<547519..550783,551068..551286)) IV 1 NT_166519.1 Function: N. crassa ro-3 is required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. The dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.; Remark: C-terminally truncated ORF due to the end of contig.; Remark: alternate names for N. crassa ro-3: p150Glued, Dynactin 150 kDa isoform,DP-150, DAP-150 or 150 kDa Dynein-associated polypeptide.; Title: strong similarity to 150 kDa Dynein-associated polypeptide ro-3 - Neurospora crassa [truncated ORF]; cytoskeleton; See PMID 8744947; See PMID 10878138; uncharacterized protein 551286 4978723 An02g02370 Aspergillus niger uncharacterized protein XP_059599908.1 547519 R 5061 CDS An02g02380 4978724 complement(join(551720..552411,552477..552512,552574..552586,552651..552725)) IV 1 NT_166519.1 Remark: Expression of the SSM1 gene was found to be repressed in the transcription elongation factor S-II null mutant. Ssm1 confers yeast resistance to 6-azauracil.; Remark: alternate names for S. cerevisiae Ssm1: Sdt1 or YGL224c.; Title: strong similarity to hypothetical suppressor of deletion of TFIIS Ssm1 - Saccharomyces cerevisiae; See PMID 10858443; uncharacterized protein 552725 4978724 An02g02380 Aspergillus niger uncharacterized protein XP_059599909.1 551720 R 5061 CDS An02g02390 4978725 553753..556197 IV 1 NT_166519.1 Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: similarity to Ser/Arg-related nuclear matrix protein SRM160 - Homo sapiens; nucleus; See PMID 10339552; See PMID 10668804; uncharacterized protein 556197 4978725 An02g02390 Aspergillus niger uncharacterized protein XP_001399380.3 553753 D 5061 CDS An02g02400 84590248 complement(join(557024..557043,557156..>557228)) IV 1 NT_166519.1 Remark: N-terminally truncated ORF due to the end of contig.; hypothetical protein [truncated ORF] 557228 84590248 An02g02400 Aspergillus niger hypothetical protein [truncated ORF] XP_059599910.1 557024 R 5061 CDS An02g02410 4978727 join(558882..559319,559388..559669,559721..560182,560234..560558,560605..560969,561016..561213,561261..562121) IV 1 NT_166519.1 Induction: HBP undergoes up-regulation in response to cholesterol loading of cells.; Pathway: the 110-kDa membrane protein HBP is a component of a cellular pathway that facilitates removal of excess cholesterol from cells, perhaps through its interaction with HDL.; Remark: HBP preferentially binds HDL apolipoproteins.; Title: similarity to high density lipoprotein-binding protein HBP - Homo sapiens; plasma membrane; See PMID 1318310; uncharacterized protein 562121 4978727 An02g02410 Aspergillus niger uncharacterized protein XP_001399382.3 558882 D 5061 CDS An02g02420 84590249 complement(join(562741..562845,563082..563084)) IV 1 NT_166519.1 hypothetical protein 563084 84590249 An02g02420 Aspergillus niger hypothetical protein XP_059599911.1 562741 R 5061 CDS An02g02430 84590250 join(563810..563884,564076..564172,564251..564288,564378..564488) IV 1 NT_166519.1 Title: weak similarity to G-protein coupled human rhodopsin from patent WO9405695-A1 - Homo sapiens; uncharacterized protein 564488 84590250 An02g02430 Aspergillus niger uncharacterized protein XP_059599912.1 563810 D 5061 CDS An02g02440 84590251 join(564674..564820,564917..565006,565097..565215,565377..565603,565704..565843) IV 1 NT_166519.1 hypothetical protein 565843 84590251 An02g02440 Aspergillus niger hypothetical protein XP_059599913.1 564674 D 5061 CDS An02g02450 84590252 join(566418..566560,566688..566814,567040..567209,567515..567640,567766..567869,567949..568080,568183..568257,568371..568469,568547..568587) IV 1 NT_166519.1 hypothetical protein 568587 84590252 An02g02450 Aspergillus niger hypothetical protein XP_059599914.1 566418 D 5061 CDS An02g02460 4978732 569418..570359 IV 1 NT_166519.1 hypothetical protein 570359 4978732 An02g02460 Aspergillus niger hypothetical protein XP_001399387.1 569418 D 5061 CDS An02g02470 84590253 join(572591..572763,572858..572969) IV 1 NT_166519.1 hypothetical protein 572969 84590253 An02g02470 Aspergillus niger hypothetical protein XP_059599915.1 572591 D 5061 CDS An02g02480 4978734 join(573936..574252,574317..574484,574542..574684,574743..576112) IV 1 NT_166519.1 Function: PT1 has a role in the acquisition of phosphate from the environment.; Induction: PT1 transcript levels increase in response to phosphate starvation.; Induction: PT1 transcripts are present in roots and were not detected in leaves.; Similarity: PT1 shares identity with high-affinity phosphate transporters from Arabidopsis, yeast, Neurospora crassa.; Title: strong similarity to inorganic phosphate transport protein PT1 - Medicago truncatula; plasma membrane; See PMID 9425684; uncharacterized protein 576112 4978734 An02g02480 Aspergillus niger uncharacterized protein XP_001399389.1 573936 D 5061 CDS An02g02490 4978735 complement(join(576880..577679,577731..578043,578169..578270,578325..578893,578949..579178,579225..579235)) IV 1 NT_166519.1 Function: functional rad9 cognates from S. malidevorans can restore radioresistance and the radiation-induced G2 delay response to S. pombe rad9 deletion cells.; Function: rad9p from S. pombe is involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation.; Title: similarity to DNA repair protein rad9p -Schizosaccharomyces malidevorans; See PMID 7821792; uncharacterized protein 579235 4978735 An02g02490 Aspergillus niger uncharacterized protein XP_059599916.1 576880 R 5061 CDS An02g02500 4978736 join(580093..580229,580287..580541,580591..580715,580794..580838,580903..581050,581100..582028,582080..582120) IV 1 NT_166519.1 hypothetical protein 582120 4978736 An02g02500 Aspergillus niger hypothetical protein XP_059599917.1 580093 D 5061 CDS An02g02510 4978737 join(582571..582960,583018..584739,584796..585353,585405..586145,586199..587182) IV 1 NT_166519.1 Catalytic activity: N deoxynucleoside triphosphate = N pyrophosphate + DNA(N).; Function: POL1 catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.; Remark: POL1 cannot initiate a chain de novo but requires a primer which may be DNA or RNA.; Similarity: POL1 belongs to DNA-polymerase type-B family.; Title: strong similarity to polymerase I Pol1 -Saccharomyces cerevisiae; nucleus; See PMID 3047550; See PMID 3287376; uncharacterized protein 587182 4978737 An02g02510 Aspergillus niger uncharacterized protein XP_059599918.1 582571 D 5061 CDS An02g02520 4978738 join(587342..587586,587653..587834,587887..587969,588036..588580,588639..588789,588843..588908,588977..589085,589162..589377,589443..589570) IV 1 NT_166519.1 Function: thi-4 is believed to be involved in the condensation of pyrimidine and thiazole precursors, which is necessary for the synthesis of thiamine.; Title: strong similarity to thiamin biosynthesis protein thi-4 - Neurospora crassa; See PMID 8662211; uncharacterized protein 589570 4978738 An02g02520 Aspergillus niger uncharacterized protein XP_001399393.3 587342 D 5061 CDS An02g02530 4978739 join(590198..590244,590489..591678,591734..591841,592347..592475,592534..592757) IV 1 NT_166519.1 Complex: the nucleolar protein fibrillarin interacts with p68.; Function: a role for p68 is either in postmitotic nucleolar reassembly or in the activation of ribosomal DNA transcription/preribosomal RNA processing.; Localization: p68 shows a distinct granular distribution in the nucleus.; Similarity: p68 shows extensive homology with the translation initiation factor eIF-4A.; Similarity: p68 was first identified because of its specific immunological cross-reaction with the DNA tumour virus nuclear oncogene SV40 large T.; Title: strong similarity to ATP-dependent RNA helicase p68 - Homo sapiens; nucleus; See PMID 10837141; See PMID 10648785; uncharacterized protein 592757 4978739 An02g02530 Aspergillus niger uncharacterized protein XP_001399394.3 590198 D 5061 CDS An02g02540 4978740 complement(join(594501..595143,595198..595324,595571..595760)) IV 1 NT_166519.1 Catalytic activity: an acetic ester + H(2)O <=> an alcohol + acetate.; Remark: acetyl esterase I is active on acetylated xylan and mannan.; Remark: acetyl esterase I is used in the preparation of feed or food, and in the paper or pulp industry.; Title: strong similarity to acetyl-esterase I from patent WO9502689-A - Aspergillus aculeatus; uncharacterized protein 595760 4978740 An02g02540 Aspergillus niger uncharacterized protein XP_059599919.1 594501 R 5061 CDS An02g02550 84590254 join(596133..596461,596552..596611,596651..596749,597044..597122,597208..597254,597326..597401) IV 1 NT_166519.1 hypothetical protein 597401 84590254 An02g02550 Aspergillus niger hypothetical protein XP_059599920.1 596133 D 5061 CDS An02g02560 84590255 join(597465..597519,597759..597845,598116..598166,598258..598434,598472..598653) IV 1 NT_166519.1 hypothetical protein 598653 84590255 An02g02560 Aspergillus niger hypothetical protein XP_059599921.1 597465 D 5061 CDS An02g02570 84590256 complement(join(598990..599123,599421..599451,599489..599542)) IV 1 NT_166519.1 hypothetical protein 599542 84590256 An02g02570 Aspergillus niger hypothetical protein XP_059599922.1 598990 R 5061 CDS An02g02580 84590257 complement(join(601407..601631,601835..601853,601971..602057,602292..602428)) IV 1 NT_166519.1 hypothetical protein 602428 84590257 An02g02580 Aspergillus niger hypothetical protein XP_059599923.1 601407 R 5061 CDS An02g02600 4978745 join(605688..606039,606127..606323,606568..606748,607109..607464) IV 1 NT_166519.1 Title: strong similarity to hypothetical transcriptional regulator CON7 - Magnaporthe grisea; uncharacterized protein 607464 4978745 An02g02600 Aspergillus niger uncharacterized protein XP_059599924.1 605688 D 5061 CDS An02g02610 84590258 complement(join(608101..608819,608999..609038,609093..609139,609178..609263,609667..609698)) IV 1 NT_166519.1 hypothetical protein 609698 84590258 An02g02610 Aspergillus niger hypothetical protein XP_059599925.1 608101 R 5061 CDS An02g02620 4978747 join(610131..610757,610849..>611325) IV 1 NT_166519.1 Remark: C-terminally truncated due to contig border.; Title: weak similarity to hypothetical protein T21J18.80 - Arabidopsis thaliana [truncated orf]; uncharacterized protein 611325 4978747 An02g02620 Aspergillus niger uncharacterized protein XP_001399402.3 610131 D 5061 CDS An02g02630 84590259 611506..612348 IV 1 NT_166519.1 Title: weak similarity to hypothetical ABC-transporter yvfR - Bacillus cereus; uncharacterized protein 612348 84590259 An02g02630 Aspergillus niger uncharacterized protein XP_059599926.1 611506 D 5061 CDS An02g02640 4978749 join(612969..613056,613180..613412,613560..613597,613656..613808,613868..614117) IV 1 NT_166519.1 Complex: the regulation of vesicular transport in eukaryotic cells involves Ras-like GTPases of the Ypt/Rab family. The S. cerevisiae Yip1 protein specifically binds to the transport GTPases Ypt1p and Ypt31p.; Golgi; Remark: alternate name for S. cerevisiae Yip1: YGR172C.; Similarity: the ORF encoded protein shows strong similarity to human secreted protein encoded by gene 82 clone HSKHL65 from patent WO9842738-A1, but its function is not clearly enough decribed.; Title: similarity to Golgi membrane protein Yip1 -Saccharomyces cerevisiae; See PMID 11278413; See PMID 9724632; uncharacterized protein 614117 4978749 An02g02640 Aspergillus niger uncharacterized protein XP_059599927.1 612969 D 5061 CDS An02g02645 84590260 join(614201..614287,614348..614587,614642..614743,614954..615007) IV 1 NT_166519.1 hypothetical protein 615007 84590260 An02g02645 Aspergillus niger hypothetical protein XP_059599928.1 614201 D 5061 CDS An02g02650 4978751 join(615127..615163,615256..615291,615367..615878,615942..616458,616511..616818,616870..616935) IV 1 NT_166519.1 Complex: Yrb2p binds to GTP-Gsp1p, but not to GDP-Gsp1p. Yrb2p also binds to the Ran nucleotide exchanger Prp20p/Rcc1 as well as to a novel 150-kDa GTP-binding protein.; Function: Yrb2p is involved in export of nuclear export signal (NES)-containing proteins out of the nucleus.; Localization: Yrb2p is located inside the nucleus,and this localization relies on the N terminus.; Remark: Yrb2p interacts with Xpo1p and not with other members of the importin/karyopherin beta superfamily.; Remark: the Ran binding domain of Yrb2p is essential for function and for its association with Prp20p and the GTP-binding proteins.; Similarity: the predicted A. niger protein shows similarity to Yrb2p (YRB2) of S. cerevisiae, a brefeldin A resistance protein from S. pombe, which is the S. pombe orthologue of Yrb2p of S. cerevisiae, and nuclear pore protein NUP2 from S. cerevisiae. the systematic name of yeast Yrb2p is YIL063c.; Title: similarity to protein Yrb2 - Saccharomyces cerevisiae; nucleus; See PMID 9121474; See PMID 9395535; See PMID 9636166; See PMID 10050047; uncharacterized protein 616935 4978751 An02g02650 Aspergillus niger uncharacterized protein XP_001399406.1 615127 D 5061 CDS An02g02660 4978752 complement(join(617664..617719,617761..617792,617996..618054,618125..618703,618770..619225,619301..619548,619611..619701)) IV 1 NT_166519.1 Remark: alternate name for S. cerevisiae Dcw1 is YKL046c.; Title: strong similarity to hypothetical protein Dcw1 - Saccharomyces cerevisiae; uncharacterized protein 619701 4978752 An02g02660 Aspergillus niger uncharacterized protein XP_001399407.3 617664 R 5061 CDS An02g02680 4978754 join(620768..623465,623511..623884,623957..624349) IV 1 NT_166519.1 Function: the musN gene from E. nidulans was identified in a screen searching for methyl methane-sulfonate (MMS)-sensitive and radiation-induced mutants. Further characterization showed the musN mutation apparently caused high levels solely of mitotic crossing over.; Similarity: the ORF encoded protein is strong similar to many probable RNA helicases e. g. SPAC23A1. 19c (S. pombe) and YDR291w (S. cerevisiae).; Title: similarity to RecQ helicase musN -Aspergillus nidulans; See PMID 1582555; uncharacterized protein 624349 4978754 An02g02680 Aspergillus niger uncharacterized protein XP_059599929.1 620768 D 5061 CDS An02g02690 4978755 complement(join(625150..625950,626008..627114)) IV 1 NT_166519.1 Similarity: the Pro1 protein from Sordaria macrospora is a zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type.; Title: similarity to transcription factor required for fruiting body development Pro1 - Sordaria macrospora; See PMID 10224253; uncharacterized protein 627114 4978755 An02g02690 Aspergillus niger uncharacterized protein XP_001399409.3 625150 R 5061 CDS An02g02700 4978756 complement(join(627954..628196,628312..628722)) IV 1 NT_166519.1 Catalytic activity: 10-formyltetrahydrofolate + 5'-phosphoribosylglycinamide <=> tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide.; Pathway: the S. cerevisiae Ade8 gene product is involved in third step (the first of two transformylation reactions) in de novo purine biosynthesis.; Remark: alternate names for S. cerevisiae Ade8: YDR408c,GART or GARtransformylase.; Title: strong similarity to phosphoribosylglycinamide formyltransferase Ade8 -Saccharomyces cerevisiae; See PMID 2183217; See PMID 4581491; uncharacterized protein 628722 4978756 An02g02700 Aspergillus niger uncharacterized protein XP_001399410.1 627954 R 5061 CDS An02g02710 4978757 complement(join(629729..629836,629890..630165,630196..632406)) IV 1 NT_166519.1 Remark: A splice site was detected upstream of the START codon.; Similarity: the ORF encoded protein shows also strong similarity to the S. pombe hypothetical protein SPBP4H10. 07, but the similarity to SPCC4G3. 12c is more extented. It also show many hits to hypothetical Arabidopsis thaliana RING-H2 finger proteins.; Title: strong similarity to hypothetical RING finger protein SPCC4G3.12c - Schizosaccharomyces pombe; uncharacterized protein 632406 4978757 An02g02710 Aspergillus niger uncharacterized protein XP_059605087.1 629729 R 5061 CDS An02g02720 4978758 633926..635263 IV 1 NT_166519.1 Function: Colicins are polypeptide toxins produced by and active against, Escherichia coli and closely related bacteria.; Function: the Colicin E9 is a plasmid-coded bactericidal protein with an endonuclease activity for both single-and double-stranded DNA with undefined specificity.; Title: similarity to Colicin E9 - Escherichia coli; See PMID 9716496; See PMID 2646600; uncharacterized protein 635263 4978758 An02g02720 Aspergillus niger uncharacterized protein XP_001399412.1 633926 D 5061 CDS An02g02730 4978759 635691..637304 IV 1 NT_166519.1 Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942; uncharacterized protein 637304 4978759 An02g02730 Aspergillus niger uncharacterized protein XP_059605088.1 635691 D 5061 CDS An02g02740 4978760 complement(join(638032..639889,639920..640290)) IV 1 NT_166519.1 Complex: Rabex-5 from Bos taurus forms a tight physical complex with Rabaptin-5, and this complex is essential for endocytic membrane fusion.; Function: Rabex-5 displays GDP/GTP exchange activity on Rab5(a small GTPase Rab5 which plays an essential role in endocytic traffic) upon delivery of the GTPase to the membrane.; Similarity: the ORF encoded protein and the Rabex-5 protein from Bos taurus show similarity to the VPS9 protein from S. cerevisiae which is required for Golgi to vacuole trafficking.; Title: similarity to Rab5 GDP/GTP exchange factor Rabex-5 - Bos taurus; See PMID 9323142; See PMID 10633070; uncharacterized protein 640290 4978760 An02g02740 Aspergillus niger uncharacterized protein XP_059605089.1 638032 R 5061 CDS An02g02750 4978761 complement(join(640992..642422,642472..642524,642599..642620)) IV 1 NT_166519.1 Catalytic activity: 2 H(2)O(2) <=> O(2) + 2 H(2)O.; Cofactor: Heme; Manganese.; Function: the catalase occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.; Title: strong similarity to catalase cta1p -Schizosaccharomyces pombe; See PMID 8537298; See PMID 10380645; uncharacterized protein 642620 4978761 An02g02750 Aspergillus niger uncharacterized protein XP_001399415.1 640992 R 5061 CDS An02g02760 84590261 complement(join(644502..644839,644914..644944)) IV 1 NT_166519.1 Similarity: the similarities of the ORF encoded protein to other proteins are mainly based on repetitive structures.; Title: weak similarity to skeleton binding protein 1 Pfsbp1 - Plasmodium falciparum; uncharacterized protein 644944 84590261 An02g02760 Aspergillus niger uncharacterized protein XP_059605090.1 644502 R 5061 CDS An02g02770 84590262 join(645763..645899,645930..645957,646002..646025) IV 1 NT_166519.1 hypothetical protein 646025 84590262 An02g02770 Aspergillus niger hypothetical protein XP_059605091.1 645763 D 5061 CDS An02g02780 4978764 646134..647840 IV 1 NT_166519.1 Function: TOXA of C. carbonum exports the cyclic tetrapeptide HC-toxin, which is responsible for the maize pathogenicity of the fungus.; Function: TOXA of C. carbonum may function in self-protection against the HC-toxin and/or the secretion of HC-toxin into the extracellular milieu.; Remark: the HC-toxin exerts a potent cytostatic effect on plant and animal cells by inhibiting histone deacetylase.; Title: strong similarity to HC-toxin efflux pump TOXA - Cochliobolus carbonum; plasma membrane; See PMID 8704997; uncharacterized protein 647840 4978764 An02g02780 Aspergillus niger uncharacterized protein XP_001399418.3 646134 D 5061 CDS An02g02790 4978765 complement(join(647895..649024,649157..649430)) IV 1 NT_166519.1 Function: Filobasidiella neoformans produces a thick extracellular polysaccharide capsule, which is well recognized as a virulence factor. CAP10 from Filobasidiella neoformans is required for capsule formation.; Remark: Filobasidiella neoformans=Cryptococcus neoformans.; Title: strong similarity to capsular associated protein CAP10 - Filobasidiella neoformans; cytoplasm; See PMID 10482503; uncharacterized protein 649430 4978765 An02g02790 Aspergillus niger uncharacterized protein XP_059605092.1 647895 R 5061 CDS An02g02800 84590263 join(649975..650021,650276..650356,650408..650477,650693..650882,651167..651204,651244..651333) IV 1 NT_166519.1 hypothetical protein 651333 84590263 An02g02800 Aspergillus niger hypothetical protein XP_059605093.1 649975 D 5061 CDS An02g02810 4978767 join(653442..653762,653877..655283) IV 1 NT_166519.1 Function: Mal11 from S. cerevisiae is a high-affinity transporter for uptake of alpha-glucosides such as maltose, turanose, isomaltose,alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose. It acts with the concomitant export of a proton (symport system).; Remark: alternate names for S. cerevisiae Mal11: Agt1 or YGR289C.; Title: strong similarity to alpha-glucoside-hydrogen symporter Mal11 - Saccharomyces cerevisiae; See PMID 8594329; uncharacterized protein 655283 4978767 An02g02810 Aspergillus niger uncharacterized protein XP_001399421.1 653442 D 5061 CDS An02g02820 4978768 complement(join(655471..655520,655573..656118,656192..656329,656421..656571)) IV 1 NT_166519.1 Catalytic activity: (3S)-3-hydroxyacyl-CoA <=> trans-2(or 3)-enoyl-CoA + H(2)O.; Function: straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed by the rat mitochondrial enoyl-CoA hydratase ECHS1.; Title: strong similarity to mitochondrial enoyl-CoA hydratase ECHS1 - Rattus norvegicus; localisation:mitochondrion; See PMID 8895557; See PMID 2806264; uncharacterized protein 656571 4978768 An02g02820 Aspergillus niger uncharacterized protein XP_001399422.1 655471 R 5061 CDS An02g02830 4978769 join(657086..657154,657308..657728,657802..657881) IV 1 NT_166519.1 Golgi; Remark: the human RER1 protein complements the phenotype (mislocalization of the Sec12-reporter protein) of a S. cerevisiae rer1 mutant.; Title: strong similarity to protein RER1 - Homo sapiens; See PMID 9309388; uncharacterized protein 657881 4978769 An02g02830 Aspergillus niger uncharacterized protein XP_001399423.1 657086 D 5061 CDS An02g02840 4978770 complement(join(659087..659216,659275..659477,659532..659670,659723..661001,661174..661430,661481..661497,661549..661680,661743..661994)) IV 1 NT_166519.1 Title: similarity to protein involved in betaine lipid production btaA from patent WO200283844-A2 -Agrobacterium tumefaciens; uncharacterized protein 661994 4978770 An02g02840 Aspergillus niger uncharacterized protein XP_059605094.1 659087 R 5061 CDS An02g02850 4978771 complement(join(663653..664375,664418..665017,665068..665594,665646..665818,665871..666796)) IV 1 NT_166519.1 Remark: alternate name for B. subtilis ISP-1: IspA.; Similarity: Only the c-terminal part of the ORF encoded protein shows similarity to the serine proteinase IspA from B. subtilis, the n-terminal part shows weak similarity to the mammalian transcription factors (e. g. NF-kappa-B2).; Title: similarity to intracellular microbial serine proteinase ISP-1 - Bacillus subtilis; See PMID 3087947; uncharacterized protein 666796 4978771 An02g02850 Aspergillus niger uncharacterized protein XP_059605095.1 663653 R 5061 CDS An02g02860 4978772 join(667526..667531,667563..667986,668194..668345,668397..669905) IV 1 NT_166519.1 Title: similarity to hypothetical protein encoded by An15g05550 - Aspergillus niger; uncharacterized protein 669905 4978772 An02g02860 Aspergillus niger uncharacterized protein XP_001399426.3 667526 D 5061 CDS An02g02870 4978773 complement(join(670210..670394,670458..670714,670763..670813,670868..670961,671017..671097,671158..671179,671232..671313,671364..671412,671482..671713)) IV 1 NT_166519.1 Catalytic activity: an alcohol + NAD(+) <=> an aldehyde or ketone + NADH.; Cofactor: Zinc.; Remark: the Emericella nidulans functional cDNA encoding the alcohol dehydrogenase (ADHIII) was isolated by its ability to complement an adh1 mutation in S. cerevisiae.; Similarity: the ORF encoded protein shows also strong similarity to the alcohol-dehydrogenase from A. niger AdhA described in patent WO8704464-A.; Title: strong similarity to alcohol dehydrogenase adhIII - Aspergillus nidulans; See PMID 2998782; uncharacterized protein 671713 4978773 An02g02870 Aspergillus niger uncharacterized protein XP_059605096.1 670210 R 5061 CDS An02g02880 4978774 complement(join(672609..672635,672697..673020,673105..673188,673255..673293,673370..673444)) IV 1 NT_166519.1 Function: biochemical analyses of purified recombinant yeast ARL1 (yARL1) protein revealed properties similar to other ADP-ribosylation factors (ARFs) e. g. the ability to bind and hydrolyze GTP.; Remark: The amino terminus of Arl1 from S. cerevisiae is myristoylated.; Remark: alternate name for S. cerevisiae Alr1: YBR164c.; Title: strong similarity to ADP-ribosylation factor-like protein Arl1 - Saccharomyces cerevisiae; See PMID 9388248; uncharacterized protein 673444 4978774 An02g02880 Aspergillus niger uncharacterized protein XP_001399428.1 672609 R 5061 CDS An02g02890 4978775 join(674106..674148,674207..674285,674390..674795,674852..676483) IV 1 NT_166519.1 Similarity: the ORF encoded protein shows also similarity A. chrysogenum gamma-actin described in patent WO9839459-A1.; Similarity: the ORF encoded protein shows strong similarity to the not functionally characterized proteins from S. cervisiae ARP8 type e. g. the actin-like protein SPAC664. 02c, S. pombe.; Title: similarity to actin cps8p -Schizosaccharomyces pombe; cytoskeleton; See PMID 8292390; See PMID 8774852; See PMID 3309892; uncharacterized protein 676483 4978775 An02g02890 Aspergillus niger uncharacterized protein XP_001399429.1 674106 D 5061 CDS An02g02900 4978776 join(677152..677416,677484..678730) IV 1 NT_166519.1 Complex: Paf1 was identified by affinity chromatography, it is member of a collection of factors that associate with S. cerevisiae RNA polymerase II.; Remark: alternate name for S. cerevisiae Paf1: YBR279W.; Title: strong similarity to RNA polymerase II-associated factor Paf1 - Saccharomyces cerevisiae; nucleus; See PMID 8552095; See PMID 9891041; See PMID 10219085; uncharacterized protein 678730 4978776 An02g02900 Aspergillus niger uncharacterized protein XP_001399430.3 677152 D 5061 CDS An02g02910 4978777 join(679356..679358,679533..680051,680110..681222) IV 1 NT_166519.1 Catalytic activity: (S)-dihydroorotate + NAD(+) <=> orotate + NADH.; Cofactor: FAD; FMN.; Pathway: the PyrE gene product from Emericella nidulans is involved in the pyrimidine metabolism.; Remark: alternate name for E. nidulans PyrE: DHO-DH.; Remark: the orotate reductase PyrE from Emericella nidulans is the target site of the antifungal compound LY214352 [8-chloro-4-(2-chloro-4-fluorophenoxy) quinoline].; Title: strong similarity to orotate reductase pyrE -Aspergillus nidulans; See PMID 8660469; uncharacterized protein 681222 4978777 An02g02910 Aspergillus niger uncharacterized protein XP_059605097.1 679356 D 5061 CDS An02g02920 4978778 complement(682555..683403) IV 1 NT_166519.1 Catalytic activity: D-glyceraldehyde 3-phosphate <=> glycerone phosphate.; Pathway: the TpiA product from B. stearothermophilus is involved in Glycolysis,Gluconeogenesis,Glycerolipid metabolism, Fructose and mannose metabolism.; Similarity: the ORF encoded protein shows also strong similarity to the protein described in patent WO9928475-A2.; Title: strong similarity to triosephosphate isomerase tpiA - Bacillus stearothermophilus; See PMID 6105959; See PMID 8244026; See PMID 8421318; uncharacterized protein 683403 4978778 An02g02920 Aspergillus niger uncharacterized protein XP_001399432.1 682555 R 5061 CDS An02g02930 4978779 686251..686739 IV 1 NT_166519.1 Catalytic activity: D-ribose 5-phosphate <=> D-ribulose 5-phosphate.; Complex: ribose-5-phosphate isomerase RpiB from Escherichia coli is a homodimer.; Pathway: the RpiB product from E. coli is involved in the nonoxidative branch of the pentose phosphate pathway.; Title: strong similarity to ribose-5-phosphate isomerase rpiB - Escherichia coli; See PMID 8576032; uncharacterized protein 686739 4978779 An02g02930 Aspergillus niger uncharacterized protein XP_001399433.1 686251 D 5061 CDS An02g02940 4978780 join(687815..687897,687986..688523,688587..688820) IV 1 NT_166519.1 Function: the mammalian Chip homologue is well characterized as chaperone Pubmed 10330192.; Remark: the Drosophila melanogaster Chip protein plays a important role in fly development.; Similarity: the ORF encoded protein shows also strong similarity to the human PPRM-1 protein described in patent WO9949037-A2.; Title: strong similarity to Hsp70-interacting protein Chip - Drosophila melanogaster; See PMID 10488341; uncharacterized protein 688820 4978780 An02g02940 Aspergillus niger uncharacterized protein XP_001399434.1 687815 D 5061 CDS An02g02950 4978781 complement(join(689245..689471,689545..689705,689767..690668,690718..690879,690926..690943)) IV 1 NT_166519.1 Catalytic activity: ATP + {tetrahydrofolyl-[Glu]}(N) + L-glutamate <=> ADP + phosphate + {tetrahydrofolyl-[Glu]}(N+1).; Function: in organisms that synthesize folate coenzymes de novo, the addition of the glutamyl side chains is achieved by the action of two enzymes, dihydrofolate synthetase and folylpolyglutamate synthetase.; Remark: alternate name for S. cerevisiae Met7: YOR241w.; Title: strong similarity to tetrahydrofolylpolyglutamate synthase Met7 - Saccharomyces cerevisiae; See PMID 10799479; uncharacterized protein 690943 4978781 An02g02950 Aspergillus niger uncharacterized protein XP_059605098.1 689245 R 5061 CDS An02g02960 4978782 join(691802..692053,692161..692226,692330..692446) IV 1 NT_166519.1 Function: the ACBP type 2 from Saccharomyces carlsbergensis binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters.; Remark: alternate name for S. carlsbergensis ACBP type 2: ACB2.; Similarity: the DNA sequence of the ORF is nearly identical to the A. niger EST Nig058c.; Title: similarity to acyl-CoA-binding type 2 protein Acbp - Saccharomyces carlsbergensis; See PMID 8093000; See PMID 9434347; uncharacterized protein 692446 4978782 An02g02960 Aspergillus niger uncharacterized protein XP_001399436.1 691802 D 5061 CDS An02g02970 4978783 complement(join(692635..693360,693424..693817,693864..693976,694140..694586)) IV 1 NT_166519.1 Similarity: the ORF encoded protein shows similarity to a yet unpublished human tyrosyl-DNA phosphodiesterase TDP1 (literature about this, but which does not describe this protein directly: Pubmed 10521354).; Title: strong similarity to hypothetical protein SPCP31B10.05 - Schizosaccharomyces pombe; uncharacterized protein 694586 4978783 An02g02970 Aspergillus niger uncharacterized protein XP_059605099.1 692635 R 5061 CDS An02g02980 4978784 complement(join(694766..694960,695081..695691,695740..695877,695925..696681)) IV 1 NT_166519.1 Function: the Die2 protein promotes the expression of the inositol transporter gene ITR1 in S. cerevisiae.; Remark: alternate names for S. cerevisiae Die2: YGR227W, Alg10.; Title: strong similarity to protein influencing Itr1 expression Die2 - Saccharomyces cerevisiae; See PMID 7565092; uncharacterized protein 696681 4978784 An02g02980 Aspergillus niger uncharacterized protein XP_059605100.1 694766 R 5061 CDS An02g02990 4978785 join(696986..697099,697157..697743,697823..697931) IV 1 NT_166519.1 Title: similarity to hypothetical protein OSJNBa0049B20.21 - Oryza sativa; uncharacterized protein 697931 4978785 An02g02990 Aspergillus niger uncharacterized protein XP_001399439.1 696986 D 5061 CDS An02g03000 4978786 complement(join(698545..698841,698988..699269)) IV 1 NT_166519.1 Similarity: the ORF encoded protein shows significant similarity to S. pombe SPCC4G3. 13c and to mammalian AMFR, but this proteins are functionally not characterized.; Title: weak similarity to B-type cyclin - Nicotiana tabacum; See PMID 8580965; See PMID 9193070; uncharacterized protein 699269 4978786 An02g03000 Aspergillus niger uncharacterized protein XP_001399440.1 698545 R 5061 CDS An02g03010 4978787 complement(join(700022..700286,700339..701012,701062..701436,701485..703642,703715..703755,703813..703839)) IV 1 NT_166519.1 Function: the S. pombe Cut14 protein is involved in chromosome segregation.; Remark: better characterized are the human and the chicken homologues Pubmed 7929577;9789013;10958694; Similarity: the S. pombe Cut14 protein belongs to the SMC family.; Title: strong similarity to chromosome segregation protein cut14p - Schizosaccharomyces pombe; nucleus; See PMID 8395535; uncharacterized protein 703839 4978787 An02g03010 Aspergillus niger uncharacterized protein XP_001399441.1 700022 R 5061 CDS An02g03030 84590264 complement(join(704568..704703,704775..704932)) IV 1 NT_166519.1 hypothetical protein 704932 84590264 An02g03030 Aspergillus niger hypothetical protein XP_059605101.1 704568 R 5061 CDS An02g03060 84590265 join(707662..707673,707719..707988) IV 1 NT_166519.1 Title: weak similarity to hypothetical protein T12C22.20 - Arabidopsis thaliana; uncharacterized protein 707988 84590265 An02g03060 Aspergillus niger uncharacterized protein XP_059605102.1 707662 D 5061 CDS An02g03070 4978793 complement(join(708378..709078,709135..709890,709958..709983,710044..710081,710159..710239)) IV 1 NT_166519.1 Similarity: the ORF encoded protein and Gel3 from Aspergillus fumigatus belong to the fungal Gas1 protein family.; Title: strong similarity to glycosylphosphatidylinositol-anchored beta(1-3)glucanosyltransferase gel3 - Aspergillus fumigatus; plasma membrane; See PMID 10769178; uncharacterized protein 710239 4978793 An02g03070 Aspergillus niger uncharacterized protein XP_001399444.1 708378 R 5061 CDS An02g03100 4978795 join(712312..712693,712798..712898,712940..712976,713053..713438) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein encoded by An04g09510 - Aspergillus niger; uncharacterized protein 713438 4978795 An02g03100 Aspergillus niger uncharacterized protein XP_059605103.1 712312 D 5061 CDS An02g03090 4978796 complement(join(713750..713839,713916..714276,714325..714590,714643..714707,714760..715286,715385..715526,715594..715701,716027..716039)) IV 1 NT_166519.1 Complex: human NOT2, NOT3, NOT4 and a CAF1-like factor, CALIF form a protein complex like their yeast homologues.; Remark: the yeast CCR4-NOT protein complex is a global regulator of RNA polymerase II transcription.; Title: similarity to Not2p - Homo sapiens; See PMID 10637334; uncharacterized protein 716039 4978796 An02g03090 Aspergillus niger uncharacterized protein XP_059605104.1 713750 R 5061 CDS An02g03110 4978797 join(716762..717128,717189..717355,717492..717604,717941..718115) IV 1 NT_166519.1 Remark: YmL4 of S. cerevisiae is also called MRPL4,YLR439W, or L9753. 1.; Title: similarity to mitochondrial ribosomal protein of the large subunit Yml4 - Saccharomyces cerevisiae; See PMID 7828914; mitochondrial 54S ribosomal protein uL29m 718115 4978797 An02g03110 Aspergillus niger mitochondrial 54S ribosomal protein uL29m XP_001399447.3 716762 D 5061 CDS An02g03120 4978798 join(718445..718490,718545..718569,718631..718690,718753..718780,718862..719207,719259..719813,719867..720124,720180..720268) IV 1 NT_166519.1 Function: Regulates vesicle traffic in secretory pathway by regulating dissociation of GDP from Sec4/Ypt/rab family of GTP-binding proteins.; Title: strong similarity to GDP dissociation inhibitor in the secretory pathway Gdi1 - Saccharomyces cerevisiae; See PMID 8157010; uncharacterized protein 720268 4978798 An02g03120 Aspergillus niger uncharacterized protein XP_001399448.1 718445 D 5061 CDS An02g03130 4978799 complement(join(720561..720790,720838..720851,720882..721174)) IV 1 NT_166519.1 hypothetical protein 721174 4978799 An02g03130 Aspergillus niger hypothetical protein XP_059605105.1 720561 R 5061 CDS An02g03140 4978800 join(722194..723759,723831..724469) IV 1 NT_166519.1 Remark: ORC binds chromatin throughout the cell cycle.; Remark: origin recognition complex binds to sequences A and B1 of the DNA replication origins.; Remark: origin recognition complex(ORC) is comprised of Orc1p, Rrr1p, Orc3p, Orc4p, Orc5p, and Orc6p.; Title: similarity to origin recognition complex subunit 4-related protein orp4p - Schizosaccharomyces pombe; See PMID 10077566; See PMID 10713440; uncharacterized protein 724469 4978800 An02g03140 Aspergillus niger uncharacterized protein XP_001399450.1 722194 D 5061 CDS An02g03150 84590266 join(730756..730792,730868..730879,731132..731262,731508..731537,731590..731639,731761..731803,731873..731938) IV 1 NT_166519.1 hypothetical protein 731938 84590266 An02g03150 Aspergillus niger hypothetical protein XP_059605106.1 730756 D 5061 CDS An02g03160 4978802 join(738027..738740,738847..739975,740034..740221,740276..740422) IV 1 NT_166519.1 Function: flbA encodes an Emericella nidulans RGS (regulator of G protein signaling) domain protein that is required for control of mycelial proliferation and activation of asexual sporulation.; Title: strong similarity to developmental regulator flbA - Aspergillus nidulans; See PMID 7830576; See PMID 8895563; See PMID 11156981; uncharacterized protein 740422 4978802 An02g03160 Aspergillus niger uncharacterized protein XP_001399452.1 738027 D 5061 CDS An02g03170 84590267 complement(join(740975..741175,741311..741400,741653..741712)) IV 1 NT_166519.1 Title: weak similarity to lactose operon repressor lacI - Escherichia coli; uncharacterized protein 741712 84590267 An02g03170 Aspergillus niger uncharacterized protein XP_059605107.1 740975 R 5061 CDS An02g03180 4978804 complement(join(743016..743756,743815..743975,744063..744504)) IV 1 NT_166519.1 Complex: the S. cerevisiae Cdc73 protein was found in complexes with RNA polymerase II and Paf1p. The Cdc73p,Paf1p complex includes Gal11p TFIIb and TFIIF, but lacks TBP, TFIIH TFIIS and Srbps.; Remark: alternate name for S. cerevisiae Cdc73: YLR418c.; Title: strong similarity to DNA-directed RNA polymerase II accessory protein Cdc73 - Saccharomyces cerevisiae; nucleus; See PMID 9032243; uncharacterized protein 744504 4978804 An02g03180 Aspergillus niger uncharacterized protein XP_059605108.1 743016 R 5061 CDS An02g03190 4978805 complement(join(744765..745499,745553..746147,746179..746318)) IV 1 NT_166519.1 Title: similarity to monocarboxylate transporter MCT3 - Rattus norvegicus; See PMID 9632638; See PMID 9841555; uncharacterized protein 746318 4978805 An02g03190 Aspergillus niger uncharacterized protein XP_059605109.1 744765 R 5061 CDS An02g03200 4978806 complement(join(746526..747034,747127..747313)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein Pep2 - Nectria haematococca; uncharacterized protein 747313 4978806 An02g03200 Aspergillus niger uncharacterized protein XP_001399456.1 746526 R 5061 CDS An02g03210 4978807 complement(749014..751761) IV 1 NT_166519.1 Complex: the human SRm160 and a related protein SRm300 (the 300-kD nuclear matrix antigen recognized by mAb B4A11) form a complex that is required for the splicing of specific pre-mRNAs.; Similarity: the similarity of the ORF encoded protein to SRm160 is partly based on repetitive structures.; Title: similarity to SR-related matrix protein of 160 kD SRm160 - Homo sapiens; nucleus; See PMID 9531537; See PMID 10339552; See PMID 10694877; uncharacterized protein 751761 4978807 An02g03210 Aspergillus niger uncharacterized protein XP_001399457.1 749014 R 5061 CDS An02g03220 4978808 complement(755573..757096) IV 1 NT_166519.1 Function: the PrnB product is required for high-affinity proline transport in A. nidulans.; Title: strong similarity to proline permease prnB -Aspergillus nidulans; plasma membrane; See PMID 8550020; See PMID 2664423; See PMID 7590163; uncharacterized protein 757096 4978808 An02g03220 Aspergillus niger uncharacterized protein XP_059605110.1 755573 R 5061 CDS An02g03230 4978809 complement(join(757784..758626,758704..758886)) IV 1 NT_166519.1 Complex: the Seh1 protein from S. cerevisiae interacts with Nup84, Nup85, Nup120 and Sec13.; Function: the Seh1 protein from S. cerevisiae required for correct nuclear pore biogenesis.; Localization: the Seh1 protein from S. cerevisiae is localized at the nuclear pore complex.; Remark: alternate names for S. cerevisiae Seh1: Sec13p homolog or YGL100w.; Similarity: the ORF encoded Protein and the Seh1 protein from S. cerevisiae are strong similar to the S. cerevisiae Sec13.; Title: strong similarity to nucleoporin-interacting component Seh1 - Saccharomyces cerevisiae; nucleus; See PMID 8565072; uncharacterized protein 758886 4978809 An02g03230 Aspergillus niger uncharacterized protein XP_001399459.3 757784 R 5061 CDS An02g03240 4978810 join(759373..759617,759710..759890,759950..760930) IV 1 NT_166519.1 Catalytic activity: UDP-N-acetyl-D-glucosamine + dolichyl phosphate <=> UMP + N-acetyl-D-glucosaminyl-diphosphodolichol.; Function: the Alg7 product from S. cerevisiae catalyzes the initial step in the synthesis of dolichol-P-P-oligosaccharides.; Remark: alternate names for S. cerevisiae Alg7: Tur1, GPT or YBR243C.; Title: strong similarity to UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase Alg7 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 7873591; See PMID 2678101; uncharacterized protein 760930 4978810 An02g03240 Aspergillus niger uncharacterized protein XP_001399460.1 759373 D 5061 CDS An02g03250 4978811 join(764063..764269,764338..766449) IV 1 NT_166519.1 Catalytic activity: 3-isopropylmalate <=> 2-isopropylmaleate + H(2)O; Remark: Also: 2-isopropylmaleate + H(2)O = 3-hydroxy-4-methyl-3- carboxypentanone, thus bringing about an interconversion between the two isomers.; Title: strong similarity to 3-isopropylmalate dehydratase LEU2 - Phycomyces blakesleeanus; uncharacterized protein 766449 4978811 An02g03250 Aspergillus niger uncharacterized protein XP_001399461.1 764063 D 5061 CDS An02g03260 4978812 complement(join(767446..767494,767554..768064,768120..768325,768374..774343,774408..774583,774671..775024)) IV 1 NT_166519.1 Title: strong similarity to hypothetical cell wall alpha-glucan synthase ags1p - Schizosaccharomyces pombe; uncharacterized protein 775024 4978812 An02g03260 Aspergillus niger uncharacterized protein XP_059605111.1 767446 R 5061 CDS An02g03270 4978813 join(783085..783908,783974..784845,784904..785088) IV 1 NT_166519.1 Catalytic activity: 5-methyltetrahydrofolate + NADP(+) <=> 5,10-methylenetetrahydrofolate + NADPH; Cofactor: FAD; Remark: two contradictory functions have been assigned to yeast MET13: methylenetetrahydrofolate reductase and mitochondrial ribosomal protein.; Title: strong similarity to methylenetetrahydrofolate reductase Met13 - Saccharomyces cerevisiae; localisation:mitochondrion; uncharacterized protein 785088 4978813 An02g03270 Aspergillus niger uncharacterized protein XP_001399463.1 783085 D 5061 CDS An02g03280 4978814 complement(join(785773..785830,785916..785981,786470..787969,788115..789100)) IV 1 NT_166519.1 Title: similarity to hypothetical protein UNC-89 -Caenorhabditis elegans; See PMID 9427008; See PMID 10591098; See PMID 10677831; uncharacterized protein 789100 4978814 An02g03280 Aspergillus niger uncharacterized protein XP_001399464.3 785773 R 5061 CDS An02g03290 4978815 complement(join(790090..791166,791246..791503)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein SPCC4G3.11 - Schizosaccharomyces pombe; uncharacterized protein 791503 4978815 An02g03290 Aspergillus niger uncharacterized protein XP_001399465.1 790090 R 5061 CDS An02g03300 4978816 join(791872..791898,791962..791996,792056..792089,792161..792298,792401..792541) IV 1 NT_166519.1 Catalytic activity: ATP + H(2)O <=> ADP + phosphate; Title: strong similarity to vacuolar ATPase subunit F - Neurospora crassa; See PMID 10340846; uncharacterized protein 792541 4978816 An02g03300 Aspergillus niger uncharacterized protein XP_001399466.1 791872 D 5061 CDS An02g03310 4978817 complement(join(793182..793280,793347..793563,793621..793829)) IV 1 NT_166519.1 Title: strong similarity to hypothetical phosphatidylglycerol/phosphatidylinositol transfer protein pltpao - Aspergillus oryzae; uncharacterized protein 793829 4978817 An02g03310 Aspergillus niger uncharacterized protein XP_001399467.1 793182 R 5061 CDS An02g03320 4978818 complement(join(794533..794571,794639..794750,794801..794865,794918..795766,795825..795920,795982..796086)) IV 1 NT_166519.1 Catalytic activity: Acyl-CoA + acetyl-CoA <=> CoA + 3-oxoacyl-CoA.; Title: strong similarity to peroxisomal acetyl-CoA C-acyltransferase POT1 - Yarrowia lipolytica; peroxisome; See PMID 7916689; uncharacterized protein 796086 4978818 An02g03320 Aspergillus niger uncharacterized protein XP_001399468.1 794533 R 5061 CDS An02g03330 4978819 join(797355..797640,797696..797851,797920..799066,799136..799285,799337..799508) IV 1 NT_166519.1 Catalytic activity: long-chain fatty acyl-CoA synthetases catalyse ATP + a long-chain carboxylic acid + CoA <=> AMP + diphosphate + an acyl-CoA.; Title: strong similarity to very long-chain fatty acyl-CoA synthase Fat1 - Saccharomyces cerevisiae; See PMID 9660783; uncharacterized protein 799508 4978819 An02g03330 Aspergillus niger uncharacterized protein XP_001399469.1 797355 D 5061 CDS An02g03340 4978820 join(800035..800144,800207..800598,801039..801325,801456..801791) IV 1 NT_166519.1 Title: similarity to hypothetical protein Aut4 -Saccharomyces cerevisiae; uncharacterized protein 801791 4978820 An02g03340 Aspergillus niger uncharacterized protein XP_059605112.1 800035 D 5061 CDS An02g03350 4978821 complement(join(802273..803043,803111..803383,803463..803522)) IV 1 NT_166519.1 Title: strong similarity to hypothetical rev interacting protein mis3p - Schizosaccharomyces pombe; uncharacterized protein 803522 4978821 An02g03350 Aspergillus niger uncharacterized protein XP_001399471.1 802273 R 5061 CDS An02g03360 4978822 complement(join(804332..804606,804644..804759,804858..805051,805148..805412,805633..805789,805838..806100,806177..806298,806446..806529,806588..806707)) IV 1 NT_166519.1 Title: similarity to hypothetical protein CAD21381.1 - Neurospora crassa; uncharacterized protein 806707 4978822 An02g03360 Aspergillus niger uncharacterized protein XP_059605113.1 804332 R 5061 CDS An02g03370 84590268 join(807083..807221,807278..807447) IV 1 NT_166519.1 hypothetical protein 807447 84590268 An02g03370 Aspergillus niger hypothetical protein XP_059605114.1 807083 D 5061 CDS An02g03380 4978824 complement(join(809638..809843,809990..810203,810294..810704)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein EAA61757.1 - Aspergillus nidulans; uncharacterized protein 810704 4978824 An02g03380 Aspergillus niger uncharacterized protein XP_001399474.1 809638 R 5061 CDS An02g03390 4978825 complement(join(811712..811793,811842..812059,812108..814092,814162..814330)) IV 1 NT_166519.1 Title: strong similarity to spindle pole body protein GCP2 - Homo sapiens; See PMID 9566967; uncharacterized protein 814330 4978825 An02g03390 Aspergillus niger uncharacterized protein XP_059605115.1 811712 R 5061 CDS An02g03400 4978826 join(814950..814974,815032..815044,815114..815192,815291..815634,815724..816003) IV 1 NT_166519.1 Catalytic activity: Cleavage at Xaa-bonds in which Xaa carries a hydrophobic, basic or acidic side chain.; Complex: S. cerevisiae Pup2p is the alpha-5 subunit of the 20S proteasome core.; Remark: A multisubunit protein abundant in the cytoplasm of most eukaryotic cells, apparently containing at least three distinct endopeptidase active sites. Inhibited by mercurial reagents and some inhibitors of serine endopeptidases. Belongs to peptidase family S25.; Title: strong similarity to proteasome 20S subunit Pup2 - Saccharomyces cerevisiae; uncharacterized protein 816003 4978826 An02g03400 Aspergillus niger uncharacterized protein XP_001399476.1 814950 D 5061 CDS An02g03410 4978827 complement(816262..817782) IV 1 NT_166519.1 Title: strong similarity to protein SEQ ID NO:7875 from patent WO200253728-A2 - Candida albicans; uncharacterized protein 817782 4978827 An02g03410 Aspergillus niger uncharacterized protein XP_001399477.1 816262 R 5061 CDS An02g03420 4978828 join(818590..818764,818819..820364,820418..821567) IV 1 NT_166519.1 Title: weak similarity to fungal ZBC protein sequence #33 from patent WO200224865-A2 - unidentified organism; uncharacterized protein 821567 4978828 An02g03420 Aspergillus niger uncharacterized protein XP_001399478.1 818590 D 5061 CDS An02g03430 84590269 join(822928..822994,823063..823205) IV 1 NT_166519.1 hypothetical protein 823205 84590269 An02g03430 Aspergillus niger hypothetical protein XP_059605116.1 822928 D 5061 CDS An02g03440 84590270 complement(join(825592..825897,826211..826267)) IV 1 NT_166519.1 hypothetical protein 826267 84590270 An02g03440 Aspergillus niger hypothetical protein XP_059605117.1 825592 R 5061 CDS An02g03450 4978831 join(826457..827137,827238..827311,827355..827877) IV 1 NT_166519.1 Title: weak similarity to hypothetical protein AAA72367.1 - Homo sapiens; uncharacterized protein 827877 4978831 An02g03450 Aspergillus niger uncharacterized protein XP_059605118.1 826457 D 5061 CDS An02g03460 4978832 join(828371..828436,828544..828629,828766..828921,828991..829552,829607..829738,829800..829832) IV 1 NT_166519.1 Title: similarity to hypothetical protein YIL041w -Saccharomyces cerevisiae; uncharacterized protein 829832 4978832 An02g03460 Aspergillus niger uncharacterized protein XP_001399482.3 828371 D 5061 CDS An02g03470 84590271 complement(join(830240..830378,830487..830561,830760..830844,831016..831190,831342..831344)) IV 1 NT_166519.1 hypothetical protein 831344 84590271 An02g03470 Aspergillus niger hypothetical protein XP_059605119.1 830240 R 5061 CDS An02g03480 4978834 complement(join(831559..832617,832686..832739,832789..832977)) IV 1 NT_166519.1 Remark: cells lacking Arv1p display altered intracellular sterol distribution and are defective in sterol uptake, consistent with a role for Arv1p in trafficking sterol into the plasma membrane.; Remark: the S. cerevisiae protein is involved in sterol uptake and distribution into the plasma membrane.; Title: similarity to protein involved in sterol distribution Arv1 - Saccharomyces cerevisiae; See PMID 11063737; uncharacterized protein 832977 4978834 An02g03480 Aspergillus niger uncharacterized protein XP_001399484.1 831559 R 5061 CDS An02g03490 4978835 complement(join(833225..833481,833550..834126,834184..834552,834593..834793)) IV 1 NT_166519.1 Remark: all found proteins found are probable oxidoreductases.; Title: strong similarity to hypothetical oxidoreductase mll4186 - Mesorhizobium loti; uncharacterized protein 834793 4978835 An02g03490 Aspergillus niger uncharacterized protein XP_059605120.1 833225 R 5061 CDS An02g03500 84590272 join(834912..835126,835208..835245,835346..835405,835468..835563,835646..835860) IV 1 NT_166519.1 hypothetical protein 835860 84590272 An02g03500 Aspergillus niger hypothetical protein XP_059605121.1 834912 D 5061 CDS An02g03510 4978837 join(836295..836690,836764..837216,837259..837292,837461..837619,837650..837747) IV 1 NT_166519.1 Remark: pike AANAT-1 is nearly exclusively expressed in the retina.; Remark: serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AANAT, EC 2. 3. 1. 87) is the first enzyme in the conversion of serotonin to melatonin.; Title: similarity to arylalkylamine N-acetyltransferase AANAT1 - Esox lucius; See PMID 10085157; uncharacterized protein 837747 4978837 An02g03510 Aspergillus niger uncharacterized protein XP_059605122.1 836295 D 5061 CDS An02g03520 4978838 join(837964..837984,838070..838178,838287..838388,838475..840168,840227..840268) IV 1 NT_166519.1 Remark: CRFG mRNA was localized to the outer medulla and was highly expressed in epithelial cells. The specific renal expression of CRFG mRNA in the outer medulla was reduced dramatically in several rat models of renal disease, including diabetic nephropathy, partial nephrectomy,ischemia, and anti-Thy1. 1-induced nephritis. CRFG was localized selectively in the nucleus of human and rodent cells, as determined by immunocytochemistry and green fluorescence fusion protein.; Title: strong similarity to G protein-binding protein CRFG - Homo sapiens; See PMID 11316846; uncharacterized protein 840268 4978838 An02g03520 Aspergillus niger uncharacterized protein XP_001399488.1 837964 D 5061 CDS An02g03530 84590273 join(841113..841195,841246..841299,841374..841392,841427..841642,841721..841828) IV 1 NT_166519.1 hypothetical protein 841828 84590273 An02g03530 Aspergillus niger hypothetical protein XP_059605123.1 841113 D 5061 CDS An02g03540 4978840 complement(join(841937..843295,843355..843467,843529..843739)) IV 1 NT_166519.1 Function: low-affinity glucose transporter.; Induction: repressed at high glucose concentrations.; Remark: HXT3::lacZ in S. cerevisiae is maximally expressed after entry into stationary phase.; Similarity: belongs to the sugar transporter family.; Title: strong similarity to hexose transporter Hxt3 - Saccharomyces cerevisiae; See PMID 8417358; uncharacterized protein 843739 4978840 An02g03540 Aspergillus niger uncharacterized protein XP_001399490.1 841937 R 5061 CDS An02g03550 84590274 join(843964..844236,844609..844770) IV 1 NT_166519.1 Remark: the sequence seems to be a promotor sequence.; Title: weak similarity to hypothetical protein encoded by CG9894 - Drosophila melanogaster; uncharacterized protein 844770 84590274 An02g03550 Aspergillus niger uncharacterized protein XP_059605124.1 843964 D 5061 CDS An02g03560 84590275 complement(join(845719..845926,846011..846067,846178..846545,846623..846651,846753..847142,847259..847289,847360..847413,847488..847523,847610..847698,847756..847806,847967..848023,848127..848151,848222..848256,848323..848431)) IV 1 NT_166519.1 hypothetical protein 848431 84590275 An02g03560 Aspergillus niger hypothetical protein XP_059605125.1 845719 R 5061 CDS An02g03570 4978843 complement(join(848524..849387,849446..849622)) IV 1 NT_166519.1 Remark: YBR159w S. cerevisiae has probably 17beta-hydroxysteroid dehydrogenases (17beta-HSDs) activity.; Similarity: belongs to the dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases).; Title: strong similarity to membrane protein YBR159w - Saccharomyces cerevisiae; See PMID 11090658; uncharacterized protein 849622 4978843 An02g03570 Aspergillus niger uncharacterized protein XP_001399493.1 848524 R 5061 CDS An02g03580 4978844 849956..850405 IV 1 NT_166519.1 Remark: strong similarity to S. cerevisiae lipid metabolism protein encoded by the open reading frame YERO44c patent WO200058521-A2.; Remark: the S. cerevisiae protein is involved in the synthesis of ergosterol.; Title: strong similarity to lipid metabolism protein YER044c from patent WO200058521-A2 - Saccharomyces cerevisiae; See PMID 10929718; uncharacterized protein 850405 4978844 An02g03580 Aspergillus niger uncharacterized protein XP_059605126.1 849956 D 5061 CDS An02g03590 4978845 complement(join(851093..851198,851251..852016,852077..852261,852343..852443)) IV 1 NT_166519.1 Catalytic activity: UTP + alpha-D-Galactose 1-phosphate = pyrophosphate + UDPgalactose.; Pathway: galactose metabolism.; Remark: GAL7 converts galactose to glucose in S. cerevisiae.; Similarity: belongs to the UDPglucose-hexose-1-phosphate uridylyltransferases.; Title: strong similarity to UDP-glucose-hexose-1-phosphate uridylyltransferase Gal7 -Saccharomyces cerevisiae; See PMID 10993714; See PMID 2851900; See PMID 6715281; uncharacterized protein 852443 4978845 An02g03590 Aspergillus niger uncharacterized protein XP_001399495.1 851093 R 5061 CDS An02g03600 4978846 join(853174..853221,853286..853652,853712..854136) IV 1 NT_166519.1 hypothetical protein 854136 4978846 An02g03600 Aspergillus niger hypothetical protein XP_001399496.3 853174 D 5061 CDS An02g03610 84590276 join(854707..854744,854844..854928,855167..855397,855478..855783) IV 1 NT_166519.1 hypothetical protein 855783 84590276 An02g03610 Aspergillus niger hypothetical protein XP_059605127.1 854707 D 5061 CDS An02g03620 4978848 856003..857850 IV 1 NT_166519.1 Remark: Acremonium chrysogenum gene involved in biosynthesis of cephalosporin C patent JP09009966-A.; Remark: shows also strong similarity to YLL028w (TPO1) S. cerevisiae.; Title: strong similarity to protein involved in cephalosporin C biosynthesis from patent JP09009966-A -Acremonium chrysogenum; uncharacterized protein 857850 4978848 An02g03620 Aspergillus niger uncharacterized protein XP_001399498.3 856003 D 5061 CDS An02g03630 4978849 join(858764..859356,859403..860032,860123..860435) IV 1 NT_166519.1 Remark: all found homologues proteins are deduced to polyketid synthesis clusters in different organisms.; Title: similarity to pimaricin biosynthetic gene cluster protein pimK - Streptomyces natalensis; See PMID 11094342; uncharacterized protein 860435 4978849 An02g03630 Aspergillus niger uncharacterized protein XP_001399499.1 858764 D 5061 CDS An02g03640 4978850 join(860932..860979,861059..861931) IV 1 NT_166519.1 Catalytic activity: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH.; Pathway: valine, leucine and isoleucine degradation.; Similarity: belongs to the 3-hydroxyisobutyrate dehydrogenase and related proteins family.; Title: strong similarity to hypothetical 3-hydroxyacid dehydrogenase - Helicobacter pylori; uncharacterized protein 861931 4978850 An02g03640 Aspergillus niger uncharacterized protein XP_001399500.1 860932 D 5061 CDS An02g03650 4978851 complement(join(862141..862839,863165..863268,863317..863344)) IV 1 NT_166519.1 Remark: the protein sequence shows similarity to different prolin rich proteins with different length.; hypothetical protein 863344 4978851 An02g03650 Aspergillus niger hypothetical protein XP_001399501.3 862141 R 5061 CDS An02g03660 84590277 join(864208..864447,864539..864623,864802..864900,864993..865106,865500..865999) IV 1 NT_166519.1 hypothetical protein 865999 84590277 An02g03660 Aspergillus niger hypothetical protein XP_059605128.1 864208 D 5061 CDS An02g03670 4978853 join(866048..866328,866393..866765,866826..866909,866959..867786) IV 1 NT_166519.1 Remark: strong similarity to Acremonium chrysogenum gene involved in biosynthesis of cephalosporin C patent JP09009966-A.; Title: strong similarity to protein involved in cephalosporin C biosynthesis from patent JP09009966-A -Acremonium chrysogenum; uncharacterized protein 867786 4978853 An02g03670 Aspergillus niger uncharacterized protein XP_001399503.1 866048 D 5061 CDS An02g03690 84590278 join(868994..869059,869129..869404) IV 1 NT_166519.1 hypothetical protein 869404 84590278 An02g03690 Aspergillus niger hypothetical protein XP_059605129.1 868994 D 5061 CDS An02g03700 4978856 complement(869713..870810) IV 1 NT_166519.1 Remark: the ORF shows only to the C-terminal end weak similarity.; Title: weak similarity to nicotinic acetylcholine receptor alpha-4 chain ACh4 - Rattus norvegicus; See PMID 3829125; uncharacterized protein 870810 4978856 An02g03700 Aspergillus niger uncharacterized protein XP_001399505.1 869713 R 5061 CDS An02g03710 4978857 complement(join(871121..871500,871549..871645)) IV 1 NT_166519.1 Title: similarity to hypothetical protein CAD79137.1 - Pirellula sp.; uncharacterized protein 871645 4978857 An02g03710 Aspergillus niger uncharacterized protein XP_059605130.1 871121 R 5061 CDS An02g03720 4978858 871949..874747 IV 1 NT_166519.1 Function: involved in nucleotide excision repair of dna damaged with uv light, bulky adducts, or cross-linking agents.; Remark: Rad4. Rad23 interacts with DNA damage during NER (nucleotide excision repair) and may play a role in recognition of the damage.; Similarity: to S. pombe spac12b10. 12c and some, to mammalian xpcc.; Title: similarity to excision repair protein Rad4 -Saccharomyces cerevisiae; nucleus; See PMID 9837874; See PMID 2649477; uncharacterized protein 874747 4978858 An02g03720 Aspergillus niger uncharacterized protein XP_001399507.1 871949 D 5061 CDS An02g03728 4978859 complement(join(875793..877100,877203..877673)) IV 1 NT_166519.1 Function: Mob1p from S. cerevisiae binds Mps1p (protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation) in a two-hybrid assay.; Function: Mob1p is an essential S. cerevisiae protein; Function: Mutations in Mob1p cause a late nuclear division arrest.; Remark: Mob1p from S. cerevisiae is a phosphoprotein in vivo and a substrate for the Mps1p kinase in vitro.; Title: similarity to protein involved in cell cycle Mob1 - Saccharomyces cerevisiae; See PMID 9436989; uncharacterized protein 877673 4978859 An02g03728 Aspergillus niger uncharacterized protein XP_059606823.1 875793 R 5061 CDS An02g03730 4978860 join(877748..877868,877972..878057,878196..878292,878348..878879,878940..879192,879525..879576,879648..879691) IV 1 NT_166519.1 Function: might be involved in cobalt reduction leading to cobalt(i) corrinoids.; Pathway: cobalamin biosynthesis.; Title: strong similarity to hypothetical dopamine responsive protein - Rattus norvegicus; uncharacterized protein 879691 4978860 An02g03730 Aspergillus niger uncharacterized protein XP_059606824.1 877748 D 5061 CDS An02g03740 4978861 complement(join(879967..882315,882358..882705)) IV 1 NT_166519.1 Function: human erbB2 catalyzes the phosphorylation of a peptidyl tyrosine residue by ATP.; Remark: the ORF encoded protein shows similarity to several tyrosine kinases of different organisms.; Title: weak similarity to protein-tyrosine kinase erbB2 - Homo sapiens; deleted EC_number 2.7.1.112; uncharacterized protein 882705 4978861 An02g03740 Aspergillus niger uncharacterized protein XP_059606825.1 879967 R 5061 CDS An02g03750 84590279 complement(join(884924..885159,885282..885325,885361..885512,885596..885769,886337..886521,886661..886720,886794..886893)) IV 1 NT_166519.1 hypothetical protein 886893 84590279 An02g03750 Aspergillus niger hypothetical protein XP_059606826.1 884924 R 5061 CDS An02g03760 4978863 complement(join(887994..888155,888211..891390)) IV 1 NT_166519.1 Function: PIM1 catalyzes the initial steps of protein degradation.; Function: PIM1 degrades alpha-,beta-, and gamma-subunits of the F1ATPase, the beta-subunit of the matrix processing peptidase (Mas1p) and several mitochondrial ribosomal proteins.; Function: PIM1 probably mediates both assembly of protein complexes and degradation of disassembled proteins; Phenotype: pim1 mutant shows deficiencies in splicing of COX1 and CYTB pre-mRNA and subsequent degradation of the transcripts.; Phenotype: pim1 null mutant has a nonfunctional mitochondrial genome.; Remark: LON and YBL022C are alternative names for PIM1 in S. cerevisiae.; Title: strong similarity to precursor of endopeptidase La-like enzyme Pim1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8276800; See PMID 9585511; uncharacterized protein 891390 4978863 An02g03760 Aspergillus niger uncharacterized protein XP_001399512.1 887994 R 5061 CDS An02g03770 4978864 join(891880..892092,892163..893406,893467..893653) IV 1 NT_166519.1 Function: MDJ1 of S. cerevisiae is required for proper folding of precursor proteins being transported into the mitochondria.; Phenotype: mdj1 null mutants in S. cerevisiae have petite phenotype and are ts.; Remark: YFL016C is the systematic name for MDJ1.; Title: strong similarity to precursor of heat shock protein Mdj1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8168133; uncharacterized protein 893653 4978864 An02g03770 Aspergillus niger uncharacterized protein XP_001399513.1 891880 D 5061 CDS An02g03780 4978865 join(894674..894951,895026..896622,896681..897799) IV 1 NT_166519.1 Function: human histidine domain-protein tyrosine phosphatase might be a tumour suppressor.; Remark: the ORFencoded protein also shows similarity to the unknown protein BRO1 of S. cerevisiae. A null mutation in BRO1 is synthetically lethal with null mutations in BCK1, MPK1, which encodes a mitogen-activated protein kinase that functions downstream of Bck1p, or PKC1,a gene encoding a protein kinase C homolog that activates Bck1p.; Title: similarity to histidine domain-protein tyrosine phosphatase from patent WO200063392-A1 - Homo sapiens; uncharacterized protein 897799 4978865 An02g03780 Aspergillus niger uncharacterized protein XP_001399514.1 894674 D 5061 CDS An02g03790 4978866 complement(join(898962..899450,899561..899782)) IV 1 NT_166519.1 Remark: blastp matches are due to repetive amino acids.; hypothetical protein 899782 4978866 An02g03790 Aspergillus niger hypothetical protein XP_001399515.1 898962 R 5061 CDS An02g03800 84590280 join(901077..901239,901524..901628,901704..901760,902032..902102,902187..902367,902427..902451,902519..902636,902716..902764,902846..902890,903046..903158) IV 1 NT_166519.1 hypothetical protein 903158 84590280 An02g03800 Aspergillus niger hypothetical protein XP_059606827.1 901077 D 5061 CDS An02g03810 84590281 join(905161..905213,905298..905406,905679..905738,905790..905942,906004..906100,906338..906441,906516..906526,906594..906739,907003..907134,907202..907318,907719..907822,908176..908260,908438..908541,908581..908769) IV 1 NT_166519.1 hypothetical protein 908769 84590281 An02g03810 Aspergillus niger hypothetical protein XP_059606828.1 905161 D 5061 CDS An02g03820 84590282 join(908829..908849,908939..909023,909329..909466,909618..909794,909904..910186,911039..911205,911285..911316,911389..911440,911524..911731,911855..911903,912002..912181,912429..912551) IV 1 NT_166519.1 hypothetical protein 912551 84590282 An02g03820 Aspergillus niger hypothetical protein XP_059606829.1 908829 D 5061 CDS An02g03830 4978870 914318..915601 IV 1 NT_166519.1 Function: creA of A. nidulans is involved in carbon catabolite repression. creA of A. nidulans represses the transcription of the alcR, alcA and aldA genes by binding to a GC-rich region in their promoter.; Gene-ID: creA; Mapping: creA from A. niger is mapped to chromosome IV; see list from DSM.; Remark: creA of A. niger complements the creA204 mutation of A. nidulans.; nucleus; See PMID 8359691; catabolite repressor creA-Aspergillus niger 915601 creA 4978870 creA Aspergillus niger catabolite repressor creA-Aspergillus niger XP_001399519.1 914318 D 5061 CDS An02g03840 4978871 join(917800..917912,917990..918668) IV 1 NT_166519.1 Title: strong similarity to hypothetical DNA-binding protein creA - Aspergillus oryzae; uncharacterized protein 918668 4978871 An02g03840 Aspergillus niger uncharacterized protein XP_059606830.1 917800 D 5061 CDS An02g03850 4978872 join(919603..919675,919755..919823,919902..920017,920107..920280) IV 1 NT_166519.1 Function: snRPG of H. sapiens is associated with small nuclear ribonucleoproteins (sn-RNP) U1, U2 U4/U6 and U5, necessary for mRNA splicing.; Remark: in humans, snRNPs represent the major targets for the so-called anti-Sm auto-antibodies which are diagnostic for systemic lupus erythematosus (SLE).; Similarity: the predicted ORF belongs to the snRNP Sm proteins family.; Title: similarity to small nuclear ribonucleoprotein G snRPG - Homo sapiens; nucleus; See PMID 7744013; uncharacterized protein 920280 4978872 An02g03850 Aspergillus niger uncharacterized protein XP_001399521.3 919603 D 5061 CDS An02g03860 4978873 join(921104..921166,921284..923194,923247..925070) IV 1 NT_166519.1 Remark: the ORF encoded protein also shows strong similarity to YPL012w of S. cerevisiae. Loss of function mutations of the unknown protein YPL012w are not viable.; Title: strong similarity to hypothetical protein B1D1.160 - Neurospora crassa; uncharacterized protein 925070 4978873 An02g03860 Aspergillus niger uncharacterized protein XP_001399522.1 921104 D 5061 CDS An02g03870 84590283 complement(join(925602..925629,925736..925814,925906..925927)) IV 1 NT_166519.1 hypothetical protein 925927 84590283 An02g03870 Aspergillus niger hypothetical protein XP_059606831.1 925602 R 5061 CDS An02g03880 84590284 join(927061..927283,927354..927727) IV 1 NT_166519.1 hypothetical protein 927727 84590284 An02g03880 Aspergillus niger hypothetical protein XP_059606832.1 927061 D 5061 CDS An02g03890 84590285 join(928328..928664,928739..928816,928942..929079,929100..929305) IV 1 NT_166519.1 hypothetical protein 929305 84590285 An02g03890 Aspergillus niger hypothetical protein XP_059606833.1 928328 D 5061 CDS An02g03900 84590286 complement(join(929367..929410,929555..929742,929835..929921,930031..930328,930432..930703,930804..930936,931093..931314,931402..931570,932028..932132)) IV 1 NT_166519.1 hypothetical protein 932132 84590286 An02g03900 Aspergillus niger hypothetical protein XP_059606834.1 929367 R 5061 CDS An02g03910 84590287 complement(join(933783..933794,933827..934033)) IV 1 NT_166519.1 hypothetical protein 934033 84590287 An02g03910 Aspergillus niger hypothetical protein XP_059606835.1 933783 R 5061 CDS An02g03920 84590288 complement(join(934257..934306,934506..934604,935117..935268,935475..935659)) IV 1 NT_166519.1 hypothetical protein 935659 84590288 An02g03920 Aspergillus niger hypothetical protein XP_059606836.1 934257 R 5061 CDS An02g03930 84590289 complement(join(936915..936949,937086..937275)) IV 1 NT_166519.1 hypothetical protein 937275 84590289 An02g03930 Aspergillus niger hypothetical protein XP_059606837.1 936915 R 5061 CDS An02g03940 4978881 join(938853..939027,939112..939315,939376..939458,939518..939697,939750..939842,939898..940054,940105..940349,940405..941844) IV 1 NT_166519.1 Function: General repressor of transcription (with Tup1p); mediates glucose repression; Title: strong similarity to glucose repression mediator protein Ssn6 - Saccharomyces cerevisiae; See PMID 9733762; See PMID 3316983; uncharacterized protein 941844 4978881 An02g03940 Aspergillus niger uncharacterized protein XP_001399530.1 938853 D 5061 CDS An02g03950 4978882 join(942907..942908,942985..943016,943105..943162,943235..943391,943490..944163,944221..944476) IV 1 NT_166519.1 Function: the L3 protein is a component of the large subunit of cytoplasmic ribosomes.; Remark: L3 of S. cerevisiae is also called RPL3,TCM1, MAK8, YOR063W or YOR29-14.; Remark: putative sequence error in exon1, no start codon, frameshift between exon 1 and 2.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L3 - Saccharomyces cerevisiae; cytoplasm; See PMID 6355773; 60S ribosomal protein uL3 944476 4978882 An02g03950 Aspergillus niger 60S ribosomal protein uL3 XP_001399531.1 942907 D 5061 CDS An02g03960 4978883 join(945164..945410,945493..945752) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein CAD70372.1 - Neurospora crassa; uncharacterized protein 945752 4978883 An02g03960 Aspergillus niger uncharacterized protein XP_001399532.3 945164 D 5061 CDS An02g03970 84590290 946444..947466 IV 1 NT_166519.1 Similarity: the predicted ORF shows weak similarity to asparagine-rich proteins in different organisms.; hypothetical protein 947466 84590290 An02g03970 Aspergillus niger hypothetical protein XP_059606838.1 946444 D 5061 CDS An02g03980 4978885 join(950666..951276,951350..951530,951592..951708,951746..952268,952330..952807,952863..952914) IV 1 NT_166519.1 Function: required for synthesis of beta-1,6-glucan; directly involved in cell surface assembly; may be functionally redundant with Skn1p for beta-1,6-glucan synthesis.; Title: strong similarity to beta-glucan synthesis associated protein Kre6 - Saccharomyces cerevisiae; See PMID 1837148; See PMID 7929594; uncharacterized protein 952914 4978885 An02g03980 Aspergillus niger uncharacterized protein XP_059606839.1 950666 D 5061 CDS An02g03990 4978886 join(954031..954277,954465..954571,954651..954881,955138..955176) IV 1 NT_166519.1 hypothetical protein 955176 4978886 An02g03990 Aspergillus niger hypothetical protein XP_059606840.1 954031 D 5061 CDS An02g04000 4978887 complement(join(955964..956027,956092..957083,957144..957292,957392..957503)) IV 1 NT_166519.1 Catalytic activity: ATP + [pyruvate dehydrogenase (lipoamide)] <=> ADP + [pyruvate dehydrogenase (lipoamide)] phosphate; Function: inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylating the E1 alpha subunit, thus probably contributing to the regulation of glucose metabolism.; Title: strong similarity to pyruvate dehydrogenase kinase isoform 2 - Zea mays; uncharacterized protein 957503 4978887 An02g04000 Aspergillus niger uncharacterized protein XP_001399536.1 955964 R 5061 CDS An02g04010 4978888 join(962163..962464,962583..962914,962986..963186,963263..963687,963744..963770) IV 1 NT_166519.1 hypothetical protein 963770 4978888 An02g04010 Aspergillus niger hypothetical protein XP_059606841.1 962163 D 5061 CDS An02g04020 4978889 complement(join(964961..965211,965285..965342,965400..965406,965469..965547,965601..965673,965731..965847,965913..966640,966708..966794,966873..966924)) IV 1 NT_166519.1 Catalytic activity: N6-(1,2-dicarboxyethyl)AMP <=> fumarate + AMP; Function: Adenylosuccinate lyase ADSL is a bifunctional enzyme, which catalyzes the eight step in the de novo biosynthesis of purines and purine nucleotide recycling.; Function: Adenylosuccinate lyase is one of three enzymes that are involved the purine nucleotide cycle,which converts AMP into IMP and reconverts IMP into AMP.; Title: strong similarity to adenylosuccinate lyase ADSL - Homo sapiens; See PMID 10888601; See PMID 1529104; uncharacterized protein 966924 4978889 An02g04020 Aspergillus niger uncharacterized protein XP_001399538.1 964961 R 5061 CDS An02g04030 4978890 complement(join(967217..968891,968953..969236)) IV 1 NT_166519.1 Remark: 70 kDa exocyst component protein.; Title: strong similarity to 70 kDa exocyst component protein Exo70 - Saccharomyces cerevisiae; See PMID 8978675; uncharacterized protein 969236 4978890 An02g04030 Aspergillus niger uncharacterized protein XP_059606842.1 967217 R 5061 CDS An02g04040 4978891 969745..972264 IV 1 NT_166519.1 Catalytic activity: Phosphatidylcholine + H2O = 1-Acylglycerophosphocholine + Carboxylate.; Title: strong similarity to cytosolic phospholipase A2 beta PLA2G4 - Homo sapiens; See PMID 10358058; uncharacterized protein 972264 4978891 An02g04040 Aspergillus niger uncharacterized protein XP_001399540.1 969745 D 5061 CDS An02g04050 4978892 complement(join(972950..974562,974648..974732,974803..974805)) IV 1 NT_166519.1 Remark: P-TEN is a potential tumor suppressor, that is multiply mutated in many advanced human cancers.; Similarity: the predicted ORF is 149 amino acids longer at the C-terminus than P-TEN of H. sapiens.; Similarity: weak similarity to tensin, as the ORF probably contains a tensin domain, which is also present in P-TEN.; Title: similarity to protein-tyrosine phosphatase P-TEN - Homo sapiens; uncharacterized protein 974805 4978892 An02g04050 Aspergillus niger uncharacterized protein XP_059606843.1 972950 R 5061 CDS An02g04060 4978893 complement(975560..975982) IV 1 NT_166519.1 hypothetical protein 975982 4978893 An02g04060 Aspergillus niger hypothetical protein XP_001399542.1 975560 R 5061 CDS An02g04070 4978894 complement(join(977410..978861,978920..979558)) IV 1 NT_166519.1 Title: weak similarity to hypothetical protein BAC84898.1 - Oryza sativa; uncharacterized protein 979558 4978894 An02g04070 Aspergillus niger uncharacterized protein XP_059606844.1 977410 R 5061 CDS An02g04080 4978895 complement(join(979931..980101,980178..980369,980437..980439)) IV 1 NT_166519.1 Remark: homozygosity for the mutation led to a recessive embryonic lethal phenotype.; Remark: putative role in U6 snRNP assembly and function; Title: strong similarity to Small nuclear ribonucleoprotein Lsm4 - Mus musculus; See PMID 10629062; uncharacterized protein 980439 4978895 An02g04080 Aspergillus niger uncharacterized protein XP_001399544.1 979931 R 5061 CDS An02g04090 84590291 join(981292..982030,982068..982123) IV 1 NT_166519.1 hypothetical protein 982123 84590291 An02g04090 Aspergillus niger hypothetical protein XP_059606845.1 981292 D 5061 CDS An02g04100 4978897 complement(join(982268..983071,983117..983228,983278..983542,983614..983889,983967..983982)) IV 1 NT_166519.1 Catalytic activity: Acetyl-CoA + histone <=> CoA + acetyl-histone.; Function: may play a role in telomeric silencing.; Title: strong similarity to histone acetyltransferase Hat1 - Saccharomyces cerevisiae; See PMID 10637607; uncharacterized protein 983982 4978897 An02g04100 Aspergillus niger uncharacterized protein XP_059606846.1 982268 R 5061 CDS An02g04110 4978898 984731..985747 IV 1 NT_166519.1 Catalytic activity: (S)-3-hydroxyacyl-CoA + NAD(+) <=> 3-oxoacyl-CoA + NADH.; Title: similarity to phenylacetaldehyde dehydrogenase padA - Escherichia coli; See PMID 9109378; uncharacterized protein 985747 4978898 An02g04110 Aspergillus niger uncharacterized protein XP_059606847.1 984731 D 5061 CDS An02g04120 4978899 join(986313..986362,986447..987418,987473..987656) IV 1 NT_166519.1 Title: similarity to protein SEQ ID NO:13148 from patent EP1074617-A2 - Homo sapiens; uncharacterized protein 987656 4978899 An02g04120 Aspergillus niger uncharacterized protein XP_059606848.1 986313 D 5061 CDS An02g04130 4978900 join(989758..990180,990260..990906,990968..991679,991756..991947) IV 1 NT_166519.1 Remark: sel-10 is a negative regulator of lin-12/Notch-mediated signaling.; Title: similarity to sel-10 - Caenorhabditis elegans; See PMID 9389650; See PMID 9861048; uncharacterized protein 991947 4978900 An02g04130 Aspergillus niger uncharacterized protein XP_001399549.1 989758 D 5061 CDS An02g04140 4978902 join(992688..992885,993038..>993754) IV 1 NT_166519.1 Remark: the ORF is C-terminally truncated due to contig border.; Title: strong similarity to hypothetical protein EAA58004.1 - Aspergillus nidulans [truncated ORF]; uncharacterized protein 993754 4978902 An02g04140 Aspergillus niger uncharacterized protein XP_059606849.1 992688 D 5061 CDS An02g04150 84590292 <993882..994682 IV 1 NT_166519.1 Title: similarity to hypothetical protein encoded by An16g01110 - Aspergillus niger [truncated ORF]; uncharacterized protein 994682 84590292 An02g04150 Aspergillus niger uncharacterized protein XP_059599930.1 993882 D 5061 CDS An02g04160 4978903 join(995762..995852,996001..996651,996713..996836,996898..996949) IV 1 NT_166519.1 Remark: O3 exposure for 2 h was sufficient for Mpt1 induction in Betula pendula.; Title: strong similarity to mitochondrial phosphate translocator Mpt1 - Betula pendula; localisation:mitochondrion; See PMID 9349251; uncharacterized protein 996949 4978903 An02g04160 Aspergillus niger uncharacterized protein XP_059599931.1 995762 D 5061 CDS An02g04170 4978904 join(997467..997853,997909..998373) IV 1 NT_166519.1 Function: phosphophoryn binds tightly to collagen and is believed to initiate the formation of apatite crystals which play a central role in the mineralization process.; Remark: similarity is mainly due to repetitive sequence !; Title: weak similarity to dentin phosphoprotein precursor AAC52774.1 - Rattus norvegicus; See PMID 8702961; uncharacterized protein 998373 4978904 An02g04170 Aspergillus niger uncharacterized protein XP_059599932.1 997467 D 5061 CDS An02g04180 4978905 complement(join(999359..999435,999519..1001016)) IV 1 NT_166519.1 Title: strong similarity to hypothetical membrane protein YDL001w - Saccharomyces cerevisiae; uncharacterized protein 1001016 4978905 An02g04180 Aspergillus niger uncharacterized protein XP_059599933.1 999359 R 5061 CDS An02g04190 4978906 complement(join(1001752..1002253,1002319..1002980)) IV 1 NT_166519.1 Remark: similarities are mainly based on glutamate rich regions.; Title: similarity to hypothetical protein AAP68958.1 - Caenorhabditis elegans; uncharacterized protein 1002980 4978906 An02g04190 Aspergillus niger uncharacterized protein XP_001399555.3 1001752 R 5061 CDS An02g04200 4978907 complement(join(1003320..1003898,1003979..1004137)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein SPCC4B3.08 - Schizosaccharomyces pombe; uncharacterized protein 1004137 4978907 An02g04200 Aspergillus niger uncharacterized protein XP_001399556.1 1003320 R 5061 CDS An02g04210 4978908 complement(join(1004759..1006237,1006290..1006381,1006428..1006542,1006592..1006744,1006796..1007492,1007554..1007693)) IV 1 NT_166519.1 Function: OmCLC-3 and OmCLC-5 function as intracellular chloride channels.; Similarity: CLC channels are closely related to the mammalian CLC-3, -4, and-5 subfamily.; Title: strong similarity to chloride channel CLC-3 -Tilapia mossambica; See PMID 10082675; uncharacterized protein 1007693 4978908 An02g04210 Aspergillus niger uncharacterized protein XP_059599934.1 1004759 R 5061 CDS An02g04220 4978909 join(1007995..1015941,1015998..1022795) IV 1 NT_166519.1 Remark: putative coiled-coil protein; possible motor protein; similar to dynein.; Title: strong similarity to hypothetical coiled-coil protein SPCC737.08 - Schizosaccharomyces pombe; uncharacterized protein 1022795 4978909 An02g04220 Aspergillus niger uncharacterized protein XP_059599935.1 1007995 D 5061 CDS An02g04230 4978910 complement(1023105..>1024289) IV 1 NT_166519.1 Remark: partial similarity due to repetitive sequence.; hypothetical protein [truncated ORF] 1024289 4978910 An02g04230 Aspergillus niger hypothetical protein [truncated ORF] XP_001399559.1 1023105 R 5061 CDS An02g04240 4978911 join(1024843..1025796,1025904..1025957) IV 1 NT_166519.1 Remark: Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation.; Remark: most blastp hits are due to repetetive sequence motives.; Title: weak similarity to acinusS mRNA - Homo sapiens; See PMID 10490026; uncharacterized protein 1025957 4978911 An02g04240 Aspergillus niger uncharacterized protein XP_001399560.3 1024843 D 5061 CDS An02g04250 4978912 complement(join(1026058..1026492,1026545..1026805,1026855..1026936,1026995..1027065,1027122..1027145,1027202..1027303)) IV 1 NT_166519.1 Golgi; Remark: p58 in Rattus norvegicus is localized to tubulo-vesicular elements at the endoplasmic reticulum-Golgi interface and the cis-Golgi cisternae in pancreatic acinar cells.; Title: similarity to protein p58 - Rattus norvegicus; See PMID 8626736; See PMID 1478936; uncharacterized protein 1027303 4978912 An02g04250 Aspergillus niger uncharacterized protein XP_001399561.1 1026058 R 5061 CDS An02g04260 4978913 join(1027864..1027986,1028056..1028232) IV 1 NT_166519.1 Remark: alternate name in Schizosaccharomyces pombe = SPAC17C9. 09c; Title: strong similarity to hypothetical small hypothetical zinc-finger protein tim13p -Schizosaccharomyces pombe; uncharacterized protein 1028232 4978913 An02g04260 Aspergillus niger uncharacterized protein XP_001399562.1 1027864 D 5061 CDS An02g04270 4978914 complement(join(1029226..1029706,1029768..1030021,1030089..1030874)) IV 1 NT_166519.1 Gene-ID: pkaC; Remark: A number of transformants also showed a strongly reduced or complete absence of sporulation as phenotype, which was quickly lost upon propagation of the strains.; Remark: Transformants overexpressing pkaC were phenotypically different with respect to growth, showing a more compact colony morphology, accompanied by a more dense sporulation, especially on media containing trehalose and glycerol.; deleted EC_number 2.7.1.37; See PMID 9141684; cAMP-dependent protein kinase catalytic subunit pkaC-Aspergillus niger 1030874 pkaC 4978914 pkaC Aspergillus niger cAMP-dependent protein kinase catalytic subunit pkaC-Aspergillus niger XP_059599936.1 1029226 R 5061 CDS An02g04280 4978915 complement(join(1033078..1035103,1035168..1035635,1035741..1035763)) IV 1 NT_166519.1 Function: Sin1 of Schizosaccharomyces pombe is a conserved component of the eukaryotic of the stress-activated MAP kinase (SAPK) signal pathway.; Remark: Sin1 of Schizosaccharomyces pombe interacts with Sty1/Spc1 MAP-kinase.; Title: strong similarity to stress activated map kinase interacting protein sin1p - Schizosaccharomyces pombe; See PMID 10428959; uncharacterized protein 1035763 4978915 An02g04280 Aspergillus niger uncharacterized protein XP_001399564.1 1033078 R 5061 CDS An02g04290 4978916 complement(join(1036616..1037229,1037283..1039648,1039703..1039790,1039846..1039867,1039951..1040037)) IV 1 NT_166519.1 Function: RFC1 in S. cerevisiae is probably not involved in repair of double-stranded DNA breaks.; Function: RFC1 in S. cerevisiae may signal end of replication.; Function: RFC1 in S. cerevisiae plays a role in DNA replication and DNA repair; Title: strong similarity to replication factor C chain Rfc1 - Saccharomyces cerevisiae; nucleus; See PMID 7651383; uncharacterized protein 1040037 4978916 An02g04290 Aspergillus niger uncharacterized protein XP_001399565.1 1036616 R 5061 CDS An02g04300 4978917 join(1040377..1040434,1040497..1040964,1041036..1041214) IV 1 NT_166519.1 Remark: MRPL16 is component of the large subunit of mitochondrial ribosome in S. cerevisiae.; Remark: alternate name in S. cerevisiae = YBL038w.; Title: strong similarity to mitochondrial ribosomal protein of the large subunit L16 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 2060626; See PMID 7478995; mitochondrial 54S ribosomal protein uL16m 1041214 4978917 An02g04300 Aspergillus niger mitochondrial 54S ribosomal protein uL16m XP_059599937.1 1040377 D 5061 CDS An02g04310 4978918 complement(join(1041289..1041383,1041537..1041683,1041743..1041801,1041869..1041918)) IV 1 NT_166519.1 Remark: The ubc1 gene encodes a type II regulatory subunit of cAMP-dependent protein kinase (PKA) in Ustilago maydis.; Title: weak similarity to cAMP-dependent protein kinase type II regulatory chain uac1 - Ustilago maydis; See PMID 7995519; uncharacterized protein 1041918 4978918 An02g04310 Aspergillus niger uncharacterized protein XP_001399567.1 1041289 R 5061 CDS An02g04320 4978919 complement(join(1042482..1042506,1042565..1042620,1042678..1042776,1042830..1042998,1043061..1043683,1043748..1043834)) IV 1 NT_166519.1 Remark: RFC3 is a heteropentamer of subunits of 140/145, 40, 38, 37, and 36. 5 kDa that forms a complex with pcna in the presence of ATP.; Title: strong similarity to replication factor C 38-kDa subunit RFC3 - Homo sapiens; nucleus; See PMID 9488738; uncharacterized protein 1043834 4978919 An02g04320 Aspergillus niger uncharacterized protein XP_001399568.1 1042482 R 5061 CDS An02g04330 4978920 complement(join(1044597..1045055,1045118..1045187,1045240..1045361)) IV 1 NT_166519.1 Function: COX11 is a nuclear genes of S. cerevisiae whose product is localized in mitochondria and is required for the synthesis/assembly of cytochrome oxidase.; Title: strong similarity to assembly factor of cytochrome c oxidase Cox11 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8118433; See PMID 2167832; uncharacterized protein 1045361 4978920 An02g04330 Aspergillus niger uncharacterized protein XP_001399569.3 1044597 R 5061 CDS An02g04340 4978921 complement(join(1046770..1047666,1048099..1048210,1048306..1048361)) IV 1 NT_166519.1 Title: similarity to hypothetical protein BAA97377.1 - Arabidopsis thaliana; uncharacterized protein 1048361 4978921 An02g04340 Aspergillus niger uncharacterized protein XP_059599938.1 1046770 R 5061 CDS An02g04350 4978922 join(1049803..1049866,1049921..1051206) IV 1 NT_166519.1 Remark: CpG methylation of the recognition site greatly inhibits DNA binding, suggesting that DNA methylation may regulate the c-myc/max complex in Mus musculus in vivo.; Remark: Max forms a sequence-specific DNA-binding protein complex with myc or mad in Mus musculus.; Remark: in Mus musculus the myc-max complex is a transcriptional activator, whereas the mad-max complex is a repressor.; Similarity: Max belongs to members of the myc family of helix-loop-helix transcription factors.; Title: weak similarity to helix-loop-helix transcription factor Max - Mus musculus; nucleus; See PMID 8193530; See PMID 9308235; See PMID 1840505; uncharacterized protein 1051206 4978922 An02g04350 Aspergillus niger uncharacterized protein XP_001399571.1 1049803 D 5061 CDS An02g04360 4978923 join(1052036..1052446,1052504..1052668,1052723..1052830,1052892..1053044) IV 1 NT_166519.1 Title: similarity to hypothetical protein SPCC1235.07 - Schizosaccharomyces pombe; uncharacterized protein 1053044 4978923 An02g04360 Aspergillus niger uncharacterized protein XP_059599939.1 1052036 D 5061 CDS An02g04355 4978925 join(1054140..1054356,1054460..1054482,1054626..1054644,1054752..1054807) IV 1 NT_166519.1 Title: weak similarity to hypothetical protein CAD37032.1 - Neurospora crassa; uncharacterized protein 1054807 4978925 An02g04355 Aspergillus niger uncharacterized protein XP_059599940.1 1054140 D 5061 CDS An02g04370 84590293 join(1055010..1055049,1055102..1055856,1055915..1056111,1056167..1056218) IV 1 NT_166519.1 Similarity: weak similarity to transcription factors of the fungal Zn(2)-Cys(6) binuclear cluster type.; Title: similarity to hypothetical protein B23I11.340 - Neurospora crassa; uncharacterized protein 1056218 84590293 An02g04370 Aspergillus niger uncharacterized protein XP_059599941.1 1055010 D 5061 CDS An02g04380 4978926 join(1056601..1056643,1056712..1056954,1057005..1057058,1057113..1057163,1057230..1057372,1057430..1057607,1057736..1057809,1057855..1057947) IV 1 NT_166519.1 Title: similarity to hypothetical protein EAA68518.1 - Gibberella zeae; uncharacterized protein 1057947 4978926 An02g04380 Aspergillus niger uncharacterized protein XP_059599942.1 1056601 D 5061 CDS An02g04390 4978927 join(1059067..1059160,1059206..1059303,1059446..1059613,1059643..1059882,1059998..1060399) IV 1 NT_166519.1 Title: similarity to hypothetical protein CAD37031.1 - Neurospora crassa; uncharacterized protein 1060399 4978927 An02g04390 Aspergillus niger uncharacterized protein XP_059599943.1 1059067 D 5061 CDS An02g04400 4978928 complement(join(1061090..1061326,1061380..1061450,1061942..1063619)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein SCF91.02c - Streptomyces coelicolor; uncharacterized protein 1063619 4978928 An02g04400 Aspergillus niger uncharacterized protein XP_001399577.3 1061090 R 5061 CDS An02g04410 4978929 complement(join(1064447..1065111,1065168..1065705,1065796..1066068)) IV 1 NT_166519.1 Remark: Candida albicans FLU1 seems not to be required for the development of azole resistance in clinical isolates of Candida albicans.; Remark: Candida albicans FLU1 showed similarity to CaMDR1 (formerly BEN(r)), a member of the major facilitator superfamily of multidrug efflux transporters.; Remark: The disruption of FLU1 in C. albicans had only a slight effect on fluconazole susceptibility; however, it resulted in hypersusceptibility to mycophenolic acid,thus suggesting that this compound could be a substrate for the protein encoded by FLU1.; Title: similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353; uncharacterized protein 1066068 4978929 An02g04410 Aspergillus niger uncharacterized protein XP_001399578.1 1064447 R 5061 CDS An02g04420 4978930 complement(join(1066934..1067756,1067879..1067947,1067991..1068040,1068102..1068642,1068721..1069073,1069164..1069333,1069366..1069450,1069772..1069990)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein encoded by An12g06190 - Aspergillus niger; uncharacterized protein 1069990 4978930 An02g04420 Aspergillus niger uncharacterized protein XP_059599944.1 1066934 R 5061 CDS An02g04430 4978931 1070360..1071688 IV 1 NT_166519.1 Catalytic activity: S-Adenosyl-L-methionine = 1-Aminocyclopropane-1-carboxylate + Methylthioadenosine.; Title: strong similarity to 1-aminocyclopropane-1-carboxylate synthase acs -Penicillium citrinum; See PMID 10227140; See PMID 10737185; uncharacterized protein 1071688 4978931 An02g04430 Aspergillus niger uncharacterized protein XP_001399580.1 1070360 D 5061 CDS An02g04440 4978932 join(1072585..1073040,1073102..1073282,1073368..1073831,1073893..1074417,1074530..1074550) IV 1 NT_166519.1 Function: the S. cerevisiae homolog GAP1 encodes the low affinitiy, high capacity general aminoacid permease which is responsible for uptake of aminoacids as source of nitrogen when grown on media with limited N supply.; Induction: S. cerevisiae GAP1 expression is induced by growth on poor nitrogen sources.; Localization: Gap1p is sorted differently on different nitrogen sorces. Gap1p is found predominantly internally by growth on rich nitrogen sources. when grown on poor nitrogen sources Gap1p is sorted from the golgi to the plasma membran.; Title: strong similarity to general amino acid permease Gap1 - Saccharomyces cerevisiae; plasma membrane; uncharacterized protein 1074550 4978932 An02g04440 Aspergillus niger uncharacterized protein XP_001399581.3 1072585 D 5061 CDS An02g04450 84590294 join(1075123..1075199,1075257..1075335,1075387..1075527) IV 1 NT_166519.1 hypothetical protein 1075527 84590294 An02g04450 Aspergillus niger hypothetical protein XP_059599945.1 1075123 D 5061 CDS An02g04460 4978934 complement(join(1075828..1077130,1077305..1078132,1078177..1078463,1078516..1079052)) IV 1 NT_166519.1 Title: strong similarity to protein SEQ ID NO:7789 from patent WO200253728-A2 - Candida albicans; uncharacterized protein 1079052 4978934 An02g04460 Aspergillus niger uncharacterized protein XP_059599946.1 1075828 R 5061 CDS An02g04470 84590295 complement(join(1079770..1079928,1079969..1080055)) IV 1 NT_166519.1 hypothetical protein 1080055 84590295 An02g04470 Aspergillus niger hypothetical protein XP_059599947.1 1079770 R 5061 CDS An02g04480 4978936 1080879..1081733 IV 1 NT_166519.1 Title: strong similarity to hypothetical protein B5O22.190 - Neurospora crassa; uncharacterized protein 1081733 4978936 An02g04480 Aspergillus niger uncharacterized protein XP_001399585.1 1080879 D 5061 CDS An02g04490 84590296 complement(join(1081887..1082213,1082279..1082350)) IV 1 NT_166519.1 hypothetical protein 1082350 84590296 An02g04490 Aspergillus niger hypothetical protein XP_059599948.1 1081887 R 5061 CDS An02g04500 4978938 join(1082418..1082949,1083019..1084059,1084114..1084991) IV 1 NT_166519.1 Function: S. cerevisiae Rgp1p seems to participate in recycling of proteins from the late endosome to the Golgi.; Remark: the S. cerevisiae homolog RGP1 is significantly shorter.; Title: similarity to golgi recycling factor Rgp1 -Saccharomyces cerevisiae; uncharacterized protein 1084991 4978938 An02g04500 Aspergillus niger uncharacterized protein XP_059599949.1 1082418 D 5061 CDS An02g04510 4978939 join(1085849..1085967,1086100..1086263,1086338..1086431,1086490..1086623,1086715..1086956) IV 1 NT_166519.1 Complex: S. cerevisiae Mob1 binds the cell cycle-regulated protein kinase Dbf2p.; Function: Mob1p is part of a group of proteins, the mitotic exit network (MEN) required for the telophase/G1 transition, which includes Lte1, Tem1, Cdc5, Cdc15,Dbf2/Dbf20, and Mob1.; Induction: Expression of S. cerevisiae MOB1 is cell cycle-regulated, peaking at the at the G2/M boundary.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to protein required for completion of mitosis and maintenance of ploidy Mob1 -Saccharomyces cerevisiae; uncharacterized protein 1086956 4978939 An02g04510 Aspergillus niger uncharacterized protein XP_059599950.1 1085849 D 5061 CDS An02g04520 4978940 join(1087392..1087559,1087791..1088105,1088165..1088254,1088311..1088424) IV 1 NT_166519.1 Catalytic activity: ATP + H(2)O <=> ADP + phosphate.; Similarity: strong similarity to family of H+-transporting ATP synthases.; Similarity: the ORF shows strong similarity to expressed sequence tag seq id no:3989 of patent WO200056762-A2 from Aspergillus niger.; Title: strong similarity to H+-transporting ATP synthase delta chain precursor Atp5 - Saccharomyces cerevisiae; See PMID 7866306; uncharacterized protein 1088424 4978940 An02g04520 Aspergillus niger uncharacterized protein XP_001399589.1 1087392 D 5061 CDS An02g04530 4978941 join(1088955..1089071,1089141..1090264,1090328..1090436,1090517..1090699) IV 1 NT_166519.1 Catalytic activity: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.; Function: the E. coli homolog cfa encodes a cyclopropane fatty acid synthase that catalyzes a modification of the acyl chains of phospholipid bilayers. cfa adds a methylene group across the 9,10 position of a delta(9)- olefinic acyl chain in phosphatidylethanolamine or, more slowly, phosphatidylglycerol or phosphatidylinositol forming a cyclopropane derivative.; Title: strong similarity to cyclopropane-fatty-acyl-phospholipid synthase - Escherichia coli; uncharacterized protein 1090699 4978941 An02g04530 Aspergillus niger uncharacterized protein XP_001399590.1 1088955 D 5061 CDS An02g04540 4978942 complement(join(1091508..1091880,1091943..1092728,1092777..1092873,1092925..1094371,1094437..1094536,1094593..1094710,1094770..1094792,1094879..1094894,1094974..1095097)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein YMR196w - Saccharomyces cerevisiae; uncharacterized protein 1095097 4978942 An02g04540 Aspergillus niger uncharacterized protein XP_001399591.1 1091508 R 5061 CDS An02g04550 84590297 complement(join(1095687..1095735,1095900..1096019,1096431..1096540,1096619..1096696,1096780..1096812,1096886..1097236)) IV 1 NT_166519.1 hypothetical protein 1097236 84590297 An02g04550 Aspergillus niger hypothetical protein XP_059599951.1 1095687 R 5061 CDS An02g04555 4978944 complement(join(1097348..1097439,1097507..1097667,1097761..1097850,1097915..1097961)) IV 1 NT_166519.1 hypothetical protein 1097961 4978944 An02g04555 Aspergillus niger hypothetical protein XP_001399593.1 1097348 R 5061 CDS An02g04560 84590298 join(1098260..1098388,1098501..1098629,1098719..1099024) IV 1 NT_166519.1 hypothetical protein 1099024 84590298 An02g04560 Aspergillus niger hypothetical protein XP_059599952.1 1098260 D 5061 CDS An02g04570 84590299 complement(join(1099081..1099253,1099313..1099372,1099824..1099962,1100296..1100401,1100456..1100499)) IV 1 NT_166519.1 hypothetical protein 1100499 84590299 An02g04570 Aspergillus niger hypothetical protein XP_059599953.1 1099081 R 5061 CDS An02g04580 4978947 join(1100665..1100807,1100860..1101115,1101171..1101527) IV 1 NT_166519.1 Similarity: the ORF shows strong similarity to expressed sequence tag an_2257 from Aspergillus niger.; Title: strong similarity to hypothetical protein YAL049c - Saccharomyces cerevisiae; uncharacterized protein 1101527 4978947 An02g04580 Aspergillus niger uncharacterized protein XP_001399596.1 1100665 D 5061 CDS An02g04590 4978948 join(1102220..1102471,1102596..1103627) IV 1 NT_166519.1 Title: similarity to hypothetical monocarboxylate permease Esbp6 - Saccharomyces cerevisiae; uncharacterized protein 1103627 4978948 An02g04590 Aspergillus niger uncharacterized protein XP_059599954.1 1102220 D 5061 CDS An02g04600 84590300 join(1104079..1104172,1104225..1104541,1104663..1104818) IV 1 NT_166519.1 hypothetical protein 1104818 84590300 An02g04600 Aspergillus niger hypothetical protein XP_059599955.1 1104079 D 5061 CDS An02g04610 84590301 complement(join(1105391..1105818,1105925..1106012)) IV 1 NT_166519.1 hypothetical protein 1106012 84590301 An02g04610 Aspergillus niger hypothetical protein XP_059603384.1 1105391 R 5061 CDS An02g04620 4978951 1106264..1109053 IV 1 NT_166519.1 Remark: similarities are mainly based on repetetive structures.; Remark: there is also some similarity to EST SEQ ID NO:6064 from patent WO200056762-A2 of Aspergillus oryzae.; Title: similarity to S-layer protein - Clostridium thermocellum; See PMID 8458832; uncharacterized protein 1109053 4978951 An02g04620 Aspergillus niger uncharacterized protein XP_001399600.1 1106264 D 5061 CDS An02g04630 4978952 complement(join(1109291..1110444,1110528..1110678)) IV 1 NT_166519.1 Remark: diphtheria toxin inhibits eukaryotic protein synthesis by ADP-ribosylating diphthamide, a posttranslationally modified histidine residue present in EF2.; Remark: strong similarity to Amino acid sequecne of the DPH1 gene product patent WO9953762-A1.; Title: strong similarity to diphtheria toxin resistance protein DPH1 from patent WO9953762-A1 -Saccharomyces cerevisiae; uncharacterized protein 1110678 4978952 An02g04630 Aspergillus niger uncharacterized protein XP_001399601.1 1109291 R 5061 CDS An02g04640 4978953 join(1110958..1111212,1111299..1112108) IV 1 NT_166519.1 Catalytic activity: (S)-3-hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate.; Pathway: synthesis and degradation of ketone bodies; valine, leucine and isoleucine degradation; butanoate metabolism.; Remark: rat liver, cannot produce ketone bodies from fatty acid oxidation but, since the tissue possesses a high activity of HMG-CoA lyase, it produce ketone bodies from leucine catabolism.; Similarity: belongs to the HMG-CoA lyase family.; Title: strong similarity to 3-hydroxy-3-methylglutaryl CoA lyase HMG-CoA lyase - Rattus norvegicus; See PMID 9798904; See PMID 10796071; See PMID 3741427; See PMID 9425122; uncharacterized protein 1112108 4978953 An02g04640 Aspergillus niger uncharacterized protein XP_001399602.1 1110958 D 5061 CDS An02g04650 84590302 complement(join(1112288..1113021,1113228..1113599,1113669..1113765)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein EAA59178.1 - Aspergillus nidulans; uncharacterized protein 1113765 84590302 An02g04650 Aspergillus niger uncharacterized protein XP_059603385.1 1112288 R 5061 CDS An02g04660 4978955 complement(1114741..1115160) IV 1 NT_166519.1 Title: similarity to hypothetical protein YBR269c -Saccharomyces cerevisiae; uncharacterized protein 1115160 4978955 An02g04660 Aspergillus niger uncharacterized protein XP_001399604.1 1114741 R 5061 CDS An02g04670 4978956 join(1115819..1115957,1116042..1116750,1116807..1117314) IV 1 NT_166519.1 Remark: BTN1 is a nonessential gene under most growth conditions which functions in the vacuole in yeast S. cerevisiae.; Remark: Batten disease is caused by a defect in vacuolar (lysosomal) pH control.; Similarity: to human Batten disease-related protein CLN3.; Title: strong similarity to Batten disease-related protein Btn1 - Saccharomyces cerevisiae; See PMID 10319861; See PMID 11053386; See PMID 11332774; See PMID 9753630; uncharacterized protein 1117314 4978956 An02g04670 Aspergillus niger uncharacterized protein XP_001399605.1 1115819 D 5061 CDS An02g04680 4978957 join(1118130..1118136,1118199..1118283,1118337..1120548) IV 1 NT_166519.1 Function: lipe of R. norvegicus is a key enzyme in fatty acid mobilization from adipose tissue triglycerides,overall energy homeostasis and probably is important in steroidogenesis.; Function: lipe of R. norvegicus is responsible for hormone-sensitive acylglycerol hydrolase and cholesteryl ester hydrolase activity in a variety of tissues.; Induction: the activity of the hormone-sensitive lipase lipe of R. norvegicus is controlled by insulin.; Title: strong similarity to hormone-sensitive lipase lipe - Rattus norvegicus; uncharacterized protein 1120548 4978957 An02g04680 Aspergillus niger uncharacterized protein XP_001399606.1 1118130 D 5061 CDS An02g04690 4978958 complement(join(<1120995..1121105,1121183..1121905,1121969..1122389,1122447..1122592,1122647..1122821)) IV 1 NT_166519.1 Function: carboxypeptidase cdpS from A. saitoi removes acidic, neutral and basic amino acids as well as proline from the C-terminal position of proteins at pH 2-5.; Function: the A. niger carboxypeptidase in addition partially digests preferentially peptides containing a hydrophobic residue in position P1, as well as arginine,lysine or phenylalanine in P1 of ester substrates.; Remark: a putative frameshift due to a possible sequencing error at position 8766 (1 bp too much) was corrected.; Repression: cdpS of A. saitoi is inhibited by DFP (diisopropyl fluorophosphate).; Similarity: the predicted ORF is strongly similar/identical to the precursor form of the published A. niger cdp-I carboxypeptidase, which mature form was described as protein of 471 amino acid, but with 9 different amino acids.; Title: strong similarity to serine-type carboxypeptidase I cdpS - Aspergillus saitoi; putative frameshift; See PMID 1637154; See PMID 7772020; See PMID 9748653; uncharacterized protein 1122821 4978958 An02g04690 Aspergillus niger uncharacterized protein XP_001399607.3 1120995 R 5061 CDS An02g04700 84590303 complement(join(1122989..1123189,1123266..1123508,1123706..1123922,1124092..1124165)) IV 1 NT_166519.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF; uncharacterized protein 1124165 84590303 An02g04700 Aspergillus niger uncharacterized protein XP_059603386.1 1122989 R 5061 CDS An02g04710 84590304 complement(join(1124924..1125139,1125242..1125522,1125635..1125759,1126039..1126100)) IV 1 NT_166519.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF; uncharacterized protein 1126100 84590304 An02g04710 Aspergillus niger uncharacterized protein XP_059603387.1 1124924 R 5061 CDS An02g04720 84590305 complement(join(1126324..1126491,1126619..1126704,1126782..1126872)) IV 1 NT_166519.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF; uncharacterized protein 1126872 84590305 An02g04720 Aspergillus niger uncharacterized protein XP_059603388.1 1126324 R 5061 CDS An02g04730 4978962 join(1126963..1127231,1127303..1128383) IV 1 NT_166519.1 Title: similarity to hypothetical membrane protein YDL237w - Saccharomyces cerevisiae; uncharacterized protein 1128383 4978962 An02g04730 Aspergillus niger uncharacterized protein XP_001399611.3 1126963 D 5061 CDS An02g04740 84590306 complement(join(1129018..1129147,1129216..1129274)) IV 1 NT_166519.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF; uncharacterized protein 1129274 84590306 An02g04740 Aspergillus niger uncharacterized protein XP_059603389.1 1129018 R 5061 CDS An02g04750 4978964 join(1130132..1130582,1131418..1131516,1131669..1133349,1133405..1134440) IV 1 NT_166519.1 Title: weak similarity to hypothetical protein encoded by CG7709 - Drosophila melanogaster; uncharacterized protein 1134440 4978964 An02g04750 Aspergillus niger uncharacterized protein XP_001399613.3 1130132 D 5061 CDS An02g04760 84590307 complement(1134622..1136142) IV 1 NT_166519.1 Title: weak similarity to hypothetical DNA-binding protein DF1 - Pisum sativum; uncharacterized protein 1136142 84590307 An02g04760 Aspergillus niger uncharacterized protein XP_059605131.1 1134622 R 5061 CDS An02g04770 84590308 complement(join(1136741..1136777,1136811..1136835,1136988..1137204)) IV 1 NT_166519.1 hypothetical protein 1137204 84590308 An02g04770 Aspergillus niger hypothetical protein XP_059605132.1 1136741 R 5061 CDS An02g04780 84590309 complement(join(1138166..1138289,1138339..1138811)) IV 1 NT_166519.1 Title: weak similarity to 3,5-cyclic-nucleotide phosphodiesterase regA - Dictyostelium discoideum; uncharacterized protein 1138811 84590309 An02g04780 Aspergillus niger uncharacterized protein XP_059605133.1 1138166 R 5061 CDS An02g04790 4978968 join(1140178..1140797,1140921..1140957) IV 1 NT_166519.1 Title: similarity to hypothetical protein encoded by An01g02260 - Aspergillus niger; uncharacterized protein 1140957 4978968 An02g04790 Aspergillus niger uncharacterized protein XP_059605134.1 1140178 D 5061 CDS An02g04800 4978969 complement(join(1141225..1142919,1143000..1143317)) IV 1 NT_166519.1 Function: sconB of E. nidulans functions as a negative regulator of sulfur metabolism.; Similarity: belongs to the met30/sconb/scon-2 family of wd-repeat proteins; Similarity: contains 8 wd repeats (trp-asp domains); Title: strong similarity to sulfur metabolite repression control protein sconB - Aspergillus nidulans; See PMID 11085267; See PMID 8479426; See PMID 9520259; uncharacterized protein 1143317 4978969 An02g04800 Aspergillus niger uncharacterized protein XP_001399618.3 1141225 R 5061 CDS An02g04810 84590310 complement(join(1144122..1144343,1144416..1144467,1144552..1144617,1144734..1144828)) IV 1 NT_166519.1 hypothetical protein 1144828 84590310 An02g04810 Aspergillus niger hypothetical protein XP_059605135.1 1144122 R 5061 CDS An02g04820 4978971 1144920..1146560 IV 1 NT_166519.1 Function: APG17 of S. cerevisiae is a component of a Apg1/Cvt9-containing complex, which is involved in autophagy, a membrane trafficking to vacuole/lysosome induced by nutrient starvation necessary for the sequestration and delivery of cytoplasmic material in vacuoles. .; Function: the apg1 complex could be necessary for switching between two distinct vesicular transport systems in a nutrient-dependent manner.; Title: similarity to cytokeratin-like protein Apg17 - Saccharomyces cerevisiae; See PMID 10582243; See PMID 10966461; See PMID 10995454; uncharacterized protein 1146560 4978971 An02g04820 Aspergillus niger uncharacterized protein XP_001399620.1 1144920 D 5061 CDS An02g04830 4978972 complement(1147697..1149403) IV 1 NT_166519.1 Remark: sudD of A. nidulans is another suppressor of the bimD6 mutation, which is a recessive,temperature-sensitive lethal mutation. at a restrictive temperature, the chromosomes of bimD6 mutant strains fail to attach properly to the spindle microtubules, and the mutant also displays a high rate of chromosome loss.; Similarity: the predicted A. niger protein shows strong similarity to the extragenic suppressor of the bimD6 mutation (sudD) of A. nidulans and orthologues of diverse eucaryotic species.; Title: strong similarity to extragenic suppressor of the bimD6 mutation sudD - Aspergillus nidulans; uncharacterized protein 1149403 4978972 An02g04830 Aspergillus niger uncharacterized protein XP_001399621.1 1147697 R 5061 CDS An02g04840 4978973 join(1149781..1149818,1149885..1150044,1150097..1153268,1153330..1153622) IV 1 NT_166519.1 Remark: DA-box proteins have been shown to function in chromosome structure and segregation.; Remark: a putative frameshift results in an premature STOP codon.; Remark: sudA of A. nidulans is a suppressor of the bimD6 mutation, which is a recessive, temperature-sensitive lethal mutation.; Similarity: the predicted A. niger protein shows strong similarity to the chromosome scaffold protein (sudA) of A. nidulans and orthologues of diverse eucaryotic species, which belong to the DA-box protein family.; Title: strong similarity to chromosome scaffold protein sudA - Aspergillus nidulans [putative frameshift]; putative frameshift; See PMID 8849887; uncharacterized protein 1153622 4978973 An02g04840 Aspergillus niger uncharacterized protein XP_059605136.1 1149781 D 5061 CDS An02g04850 4978974 complement(join(1153995..1154599,1154966..1155080)) IV 1 NT_166519.1 Remark: the matching protein is essential for viability in C. albicans.; Title: similarity to protein SEQ ID NO:7804 from patent WO200253728-A2 - Candida albicans; uncharacterized protein 1155080 4978974 An02g04850 Aspergillus niger uncharacterized protein XP_001399623.1 1153995 R 5061 CDS An02g04860 4978975 join(1155723..1155727,1155793..1155935,1156006..1156625,1156683..1156832) IV 1 NT_166519.1 Title: strong similarity to cytochrome-b5 reductase - Saccharomyces cerevisiae; See PMID 8307010; uncharacterized protein 1156832 4978975 An02g04860 Aspergillus niger uncharacterized protein XP_001399624.1 1155723 D 5061 CDS An02g04870 4978976 complement(join(1157102..1157848,1157919..1158191)) IV 1 NT_166519.1 Title: weak similarity to hypothetical phosphatidylinositol-4-phosphate 5-kinase -Schizosaccharomyces pombe; See PMID 9660759; uncharacterized protein 1158191 4978976 An02g04870 Aspergillus niger uncharacterized protein XP_059605137.1 1157102 R 5061 CDS An02g04880 4978977 join(1158724..1158948,1159031..1160325,1160380..1160793,1160852..1160858) IV 1 NT_166519.1 Catalytic activity: ATP + L-arginine + tRNA(arg) = AMP + pyrophosphate + L-arginyl-tRNA(arg); Similarity: shows stronger similarity to cytoplasmic proteins from different species than to mitochondrial localized.; Title: strong similarity to arginine--tRNA ligase Msr1 - Saccharomyces cerevisiae; See PMID 7607232; uncharacterized protein 1160858 4978977 An02g04880 Aspergillus niger uncharacterized protein XP_001399626.1 1158724 D 5061 CDS An02g04890 84590311 join(1162399..1162407,1162534..1162626,1162678..1162738,1162839..1163129,1163251..1163306,1163409..1163465,1163737..1163832,1163870..1163971) IV 1 NT_166519.1 hypothetical protein 1163971 84590311 An02g04890 Aspergillus niger hypothetical protein XP_059605138.1 1162399 D 5061 CDS An02g04900 4978979 join(1164656..1164862,1164933..1165349,1165425..1165889) IV 1 NT_166519.1 Catalytic activity: random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans; Gene-ID: pgaB; Mapping: pgaB from A. niger is mapped to chromosome IV; see EMBL Y18805.; Remark: pgaB-specific mRNA accumulates in mycelia grown on sucrose.; See PMID 10642523; endopolygalacturonases pgaB-Aspergillus niger 1165889 pgaB 4978979 pgaB Aspergillus niger endopolygalacturonases pgaB-Aspergillus niger XP_001399628.1 1164656 D 5061 CDS An02g04910 4978980 join(1167439..1167509,1167660..1167919,1167992..1168232,1168283..1168541,1168591..1169050,1169101..1169180,1169242..1169724,1169789..1169948,1170046..1170058,1170152..1170176,1170223..1170315,1170481..1170554,1170884..1170953) IV 1 NT_166519.1 Similarity: the ORF shows similarity to various ABC transporters.; Title: strong similarity to multidrug resistance ABC transporter bfr1p - Schizosaccharomyces pombe; See PMID 9537449; uncharacterized protein 1170953 4978980 An02g04910 Aspergillus niger uncharacterized protein XP_059605139.1 1167439 D 5061 CDS An02g04920 4978981 complement(1171296..>1172567) IV 1 NT_166519.1 Title: similarity to hypothetical protein encoded by An09g02960 - Aspergillus niger [truncated ORF]; uncharacterized protein 1172567 4978981 An02g04920 Aspergillus niger uncharacterized protein XP_001399630.3 1171296 R 5061 CDS An02g04930 84590312 complement(join(1173958..1174103,1174189..1174275,1174363..1174455,1174534..1174738)) IV 1 NT_166519.1 hypothetical protein 1174738 84590312 An02g04930 Aspergillus niger hypothetical protein XP_059599956.1 1173958 R 5061 CDS An02g04940 84590313 complement(join(1175034..1175174,1175273..1175329)) IV 1 NT_166519.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF; uncharacterized protein 1175329 84590313 An02g04940 Aspergillus niger uncharacterized protein XP_059599957.1 1175034 R 5061 CDS An02g04950 84590314 complement(join(1175978..1176116,1176211..1176316,1176434..1176612,1176688..1176777,1176849..1176969,1177109..1177156,1177270..1177459)) IV 1 NT_166519.1 hypothetical protein 1177459 84590314 An02g04950 Aspergillus niger hypothetical protein XP_059599958.1 1175978 R 5061 CDS An02g04960 4978985 1177668..1178834 IV 1 NT_166519.1 Title: strong similarity to hypothetical protein 68B2.80 - Neurospora crassa; uncharacterized protein 1178834 4978985 An02g04960 Aspergillus niger uncharacterized protein XP_001399634.1 1177668 D 5061 CDS An02g04970 4978986 complement(join(1179415..1180763,1180794..1180974)) IV 1 NT_166519.1 hypothetical protein 1180974 4978986 An02g04970 Aspergillus niger hypothetical protein XP_001399635.3 1179415 R 5061 CDS An02g04980 4978987 join(1181458..1181662,1181715..1181791,1181856..1182334,1182398..1183487) IV 1 NT_166519.1 Function: ddx21 of H. sapiens can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase).; Remark: ddx21 of H. sapiens is also called nuleolar RNA helicase GU, dead box protein 21 or RHII/GU.; Similarity: the ORF shows similarity to several RNA helicases from different species.; Title: strong similarity to DEAD-box RNA helicase II ddx21 - Homo sapiens; nucleus; uncharacterized protein 1183487 4978987 An02g04980 Aspergillus niger uncharacterized protein XP_001399636.1 1181458 D 5061 CDS An02g04990 4978988 complement(1183898..1185181) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein B21J21.225 - Neurospora crassa; uncharacterized protein 1185181 4978988 An02g04990 Aspergillus niger uncharacterized protein XP_059599959.1 1183898 R 5061 CDS An02g05000 4978989 complement(join(1186058..1186871,1186943..1187053,1187144..1187162,1187240..1187453)) IV 1 NT_166519.1 Function: acyltransferases catalyse the transfer of acyl groups from a donor to a variety of substrates such as glycerides, sterols, stanols and phosphatides and play a key role in lipid synthesis.; Remark: the patent WO200018889-A2 is corresponding to AAY9948 of the PATENTPROT database; the DNA is found under PATENTDNA AAA37527.; Title: strong similarity to acyltransferase yscat1 from patent WO200018889-A2 - Saccharomyces sp.; uncharacterized protein 1187453 4978989 An02g05000 Aspergillus niger uncharacterized protein XP_001399638.1 1186058 R 5061 CDS An02g05010 4978990 join(1187802..1187845,1187962..1188191,1188308..1188360) IV 1 NT_166519.1 Remark: mRpL31 of S. cerevisiae is also called YKL138c, ribosomal protein MRP31 or YmL31.; Title: strong similarity to mitochondrial ribosomal protein of the large subunit L31 - Saccharomyces cerevisiae; localisation:mitochondrion; mitochondrial 54S ribosomal protein mL60 1188360 4978990 An02g05010 Aspergillus niger mitochondrial 54S ribosomal protein mL60 XP_001399639.3 1187802 D 5061 CDS An02g05020 84590315 complement(join(1188876..1190674,1190758..1190766,1191256..1191386,1191471..1191484)) IV 1 NT_166519.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF; uncharacterized protein 1191484 84590315 An02g05020 Aspergillus niger uncharacterized protein XP_059599960.1 1188876 R 5061 CDS An02g05030 84590316 join(1192191..1192232,1192585..1192735,1193067..1193191,1193281..1193426,1193527..1193584) IV 1 NT_166519.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF; uncharacterized protein 1193584 84590316 An02g05030 Aspergillus niger uncharacterized protein XP_059599961.1 1192191 D 5061 CDS An02g05040 84590317 join(1194133..1194261,1194484..1194563,1194655..1194885,1195078..1195305,1195367..1195481) IV 1 NT_166519.1 hypothetical protein 1195481 84590317 An02g05040 Aspergillus niger hypothetical protein XP_059599962.1 1194133 D 5061 CDS An02g05050 84590318 complement(join(1195486..1195547,1195612..1195801,1195881..1196016,1196109..1196206)) IV 1 NT_166519.1 hypothetical protein 1196206 84590318 An02g05050 Aspergillus niger hypothetical protein XP_059599963.1 1195486 R 5061 CDS An02g05060 4978995 join(1197082..1197508,1197564..1197652) IV 1 NT_166519.1 hypothetical protein 1197652 4978995 An02g05060 Aspergillus niger hypothetical protein XP_001399644.1 1197082 D 5061 CDS An02g05070 84590319 complement(join(1199428..1204743,1204799..1205076,1205176..1205206)) IV 1 NT_166519.1 Remark: LPS1 activates the three amino acids of the peptide portion of ergot peptide alkaloids during D-lysergyl peptide assembly.; Title: strong similarity to d-lysergyl-peptide-synthase PS1 - Claviceps purpurea; cytoplasm; See PMID 10071219; See PMID 1281482; uncharacterized protein 1205206 84590319 An02g05070 Aspergillus niger uncharacterized protein XP_059599964.1 1199428 R 5061 CDS An02g05080 4978997 join(1206218..1206389,1206448..1207040,1207098..1207444,1207509..1207776) IV 1 NT_166519.1 Function: Mak1 from N. haematococca specifically hydroxylates the phytoalexins medicarpin and maackiain,converting them to less fungitoxic derivatives.; Localization: heterologous expression of the Mak1 cDNA construct in plants indicated that Mak1 protein accumulates in the plant cytoplasm, associated with endoplasmic reticulum membranes.; Similarity: the predicted A. niger protein shows strong similarity to Mak1 from the fungal pathogen N. haematococca. Mak1 belongs to the flavin-containing mono-oxygenases.; Title: strong similarity to maackiain detoxification protein MAK1 - Nectria haematococca; endoplasmatic reticulum; See PMID 8709942; See PMID 11485199; uncharacterized protein 1207776 4978997 An02g05080 Aspergillus niger uncharacterized protein XP_001399646.1 1206218 D 5061 CDS An02g05090 84590320 join(1207962..1207965,1208047..1208158,1208301..1208312,1208450..1208687,1208736..1208874,1209106..1209816,1209907..1210225,1210354..1210432) IV 1 NT_166519.1 Function: gibberelin synthesis in G. fujikuroi involves at least four cytochrome P450 monooxygenase-catalyzed steps and at least three P450 monooxygenases are involved, one of them beeing P450I.; Title: strong similarity to cytochrome P450 monooxygenase P450I - Gibberella fujikuroi; See PMID 9501474; See PMID 9917370; See PMID 10531641; uncharacterized protein 1210432 84590320 An02g05090 Aspergillus niger uncharacterized protein XP_059599965.1 1207962 D 5061 CDS An02g05100 4978999 complement(1210881..1211396) IV 1 NT_166519.1 Similarity: similarity of the predicted A. niger protein to various protein sequences is due to low complexity sequences.; hypothetical protein 1211396 4978999 An02g05100 Aspergillus niger hypothetical protein XP_001399648.1 1210881 R 5061 CDS An02g05110 84590321 join(1211757..1211877,1211969..1212033,1212155..1212285,1212390..1212681) IV 1 NT_166519.1 hypothetical protein 1212681 84590321 An02g05110 Aspergillus niger hypothetical protein XP_059599966.1 1211757 D 5061 CDS An02g05120 4979001 complement(1212884..1213468) IV 1 NT_166519.1 hypothetical protein 1213468 4979001 An02g05120 Aspergillus niger hypothetical protein XP_001399650.1 1212884 R 5061 CDS An02g05140 4979003 complement(join(1215203..1215249,1215297..1215765,1215910..1216694,1216831..1217135,1217281..1218096,1218144..1218568)) IV 1 NT_166519.1 Similarity: similarity of the predicted A. niger protein to various protein sequences is due to low complexity sequences.; hypothetical protein 1218568 4979003 An02g05140 Aspergillus niger hypothetical protein XP_059599967.1 1215203 R 5061 CDS An02g05150 4979004 1219861..1220772 IV 1 NT_166519.1 Catalytic activity: C-8,7 sterol isomerase of A. thaliana catalyses the isomerization of the C-8 double bond to the C-7 position within the steroid B ring.; Pathway: C-8,7 sterol isomerase of A. thaliana is involved in steroid biosynthesis.; Remark: the activity of C-8,7 sterol isomerase of A. thaliana is inhibited by the presence of sigma ligands,haloperidol, ifenprodil and verapamil.; Similarity: the predicted A. niger protein shows strong similarity to C-8,7 sterol isomerase of A. thaliana and other members of the superfamily of emopamil-binding proteins.; Title: strong similarity to C-8,7 sterol isomerase -Arabidopsis thaliana; uncharacterized protein 1220772 4979004 An02g05150 Aspergillus niger uncharacterized protein XP_001399652.1 1219861 D 5061 CDS An02g05160 4979005 complement(join(1221437..1222011,1222095..1222303,1222420..1222644,1222697..1223110,1223290..1223384)) IV 1 NT_166519.1 Title: similarity to hypothetical protein encoded by An11g09150 - Aspergillus niger; uncharacterized protein 1223384 4979005 An02g05160 Aspergillus niger uncharacterized protein XP_059599968.1 1221437 R 5061 CDS An02g05170 4979006 join(1223643..1223802,1223864..1224410,1224477..1224540,1224627..1224976,1225060..1225369) IV 1 NT_166519.1 Function: Mak1 from N. haematococca specifically hydroxylates the phytoalexins medicarpin and maackiain,converting them to less fungitoxic derivatives.; Localization: heterologous expression of the Mak1 cDNA construct in plants indicated that Mak1 protein accumulates in the plant cytoplasm, associated with endoplasmic reticulum membranes.; Remark: another ORF An02g05080 also shows strong similarity to Mak1 from N. haematococca.; Similarity: the predicted A. niger protein shows strong similarity to Mak1 from the fungal pathogen N. haematococca. Mak1 belongs to the flavin-containing mono-oxygenases.; Title: strong similarity to maackiain detoxification protein MAK1 - Nectria haematococca; endoplasmatic reticulum; See PMID 8709942; See PMID 11485199; uncharacterized protein 1225369 4979006 An02g05170 Aspergillus niger uncharacterized protein XP_001399654.1 1223643 D 5061 CDS An02g05180 10098257 complement(join(1225607..1225621,1225677..1226183)) IV 1 NT_166519.1 Similarity: similarity of the predicted A. niger protein to various protein sequences is due to low complexity sequences.; hypothetical protein 1226183 10098257 An02g05180 Aspergillus niger hypothetical protein XP_003188609.2 1225607 R 5061 CDS An02g05190 4979008 complement(join(1227464..1227893,1227990..1228585)) IV 1 NT_166519.1 Remark: the predicted A. niger protein shows strong similarity to the protein sequence of patent EP1033405-A2 (AC# AAG34578) of A. thaliana and several putative zinc finger proteins from divergent organisms.; Title: strong similarity to protein sequence a from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 1228585 4979008 An02g05190 Aspergillus niger uncharacterized protein XP_001399656.1 1227464 R 5061 CDS An02g05210 4979010 join(1229475..1229493,1229553..1230883) IV 1 NT_166519.1 Function: synexin (annexin VII) of M. musculus is a calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.; Remark: murine synexin (annexin VII) has four annexin repeats.; Similarity: the predicted A. niger protein shows similarity to murine synexin (annexin VII) and many other proteins that belong to the annexin family.; Title: strong similarity to synexin (annexin VII) -Mus musculus; See PMID 7916616; See PMID 11108960; uncharacterized protein 1230883 4979010 An02g05210 Aspergillus niger uncharacterized protein XP_001399657.1 1229475 D 5061 CDS An02g05220 4979011 complement(join(1231512..1234283,1234514..1234576)) IV 1 NT_166519.1 Function: the human Staf-50 down-regulates the transcription directed by the long terminal repeat promoter region of human immunodeficiency virus type 1 in transfected cells.; Function: the human Staf-50 is a member of the Ring finger family and contains all the features of a transcriptional regulator able to initiate a second cascade of gene induction.; Title: similarity to transcription regulator Staf-50 - Homo sapiens; See PMID 7797467; uncharacterized protein 1234576 4979011 An02g05220 Aspergillus niger uncharacterized protein XP_059599969.1 1231512 R 5061 CDS An02g05230 4979012 complement(join(1234864..1236201,1236292..1236327)) IV 1 NT_166519.1 Remark: the patent does not provide further information about the function of the protein.; Similarity: the predicted A. niger protein shows similarity to protein fragment SEQ ID NO: 65270 of patent EP1033405-A2 (AC# AAG51428) and peroxisomal membrane proteins of various species.; Title: similarity to protein fragment SEQ ID NO:65270 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 1236327 4979012 An02g05230 Aspergillus niger uncharacterized protein XP_001399659.1 1234864 R 5061 CDS An02g05240 4979013 complement(join(1237136..1237437,1237683..1237692)) IV 1 NT_166519.1 Function: histone H4 forms part of the octameric (2*H2A, 2*H2B, 2*H3, 2*H4) nucleosome core.; Title: strong similarity to histone 4 from patent WO9919502-A1 - Homo sapiens; nucleus; uncharacterized protein 1237692 4979013 An02g05240 Aspergillus niger uncharacterized protein XP_001399660.1 1237136 R 5061 CDS An02g05250 84590322 1237960..1238322 IV 1 NT_166519.1 hypothetical protein 1238322 84590322 An02g05250 Aspergillus niger hypothetical protein XP_059599970.1 1237960 D 5061 CDS An02g05260 4979015 complement(1239103..1240743) IV 1 NT_166519.1 Function: PTG of M. musculus belongs to a gene family known collectively as glycogen targeting subunits of protein phosphatase-1, that participate in the assembly and regulation of the enzymes of glycogen metabolism within mammalian cells. in addition to binding and localizing phosphatase PP1C to glycogen, PTG formes complexes with phosphorylase kinase, phosphorylase a, and glycogen synthase, the primary enzymes involved in the hormonal regulation of glycogen metabolism.; Similarity: the predicted A. niger protein shows similarity to protein phosphatase 1 binding protein (PTG,also known as PPP1R5) of M. musculus and other species.; Title: similarity to protein phosphatase 1 binding protein PTG - Mus musculus; cytoplasm; See PMID 9045612; See PMID 9756875; uncharacterized protein 1240743 4979015 An02g05260 Aspergillus niger uncharacterized protein XP_001399662.3 1239103 R 5061 CDS An02g05270 84590323 join(1241285..1241364,1241824..1241950) IV 1 NT_166519.1 hypothetical protein 1241950 84590323 An02g05270 Aspergillus niger hypothetical protein XP_059599971.1 1241285 D 5061 CDS An02g05280 84590324 complement(join(1243582..1243869,1243908..1244038,1244171..1244179,1244399..1244540)) IV 1 NT_166519.1 hypothetical protein 1244540 84590324 An02g05280 Aspergillus niger hypothetical protein XP_059599972.1 1243582 R 5061 CDS An02g05290 84590325 complement(1245149..1245505) IV 1 NT_166519.1 hypothetical protein 1245505 84590325 An02g05290 Aspergillus niger hypothetical protein XP_059599973.1 1245149 R 5061 CDS An02g05300 84590326 join(1246836..1246847,1246864..1247204,1247254..1247343,1247506..1247579,1247667..1247923) IV 1 NT_166519.1 hypothetical protein 1247923 84590326 An02g05300 Aspergillus niger hypothetical protein XP_059599974.1 1246836 D 5061 CDS An02g05310 84590327 complement(join(1248052..1248160,1248223..1248300,1248507..1248635,1248692..1248778,1248963..1249059,1249167..1249238,1249430..1249487)) IV 1 NT_166519.1 hypothetical protein 1249487 84590327 An02g05310 Aspergillus niger hypothetical protein XP_059599975.1 1248052 R 5061 CDS An02g05320 4979021 complement(1250337..1254890) IV 1 NT_166519.1 Similarity: the predicted A. niger protein shows similarity to the putative verprolin related protein of N. crassa. similarities to other protein sequences are due to low complexity sequences consisting of prolines and serines.; Title: similarity to hypothetical verprolin related protein - Neurospora crassa; uncharacterized protein 1254890 4979021 An02g05320 Aspergillus niger uncharacterized protein XP_059599976.1 1250337 R 5061 CDS An02g05330 84590328 join(1255853..1255855,1256057..1256300,1256364..1256466,1256549..1256940,1257424..1257514,1257540..1257654) IV 1 NT_166519.1 hypothetical protein 1257654 84590328 An02g05330 Aspergillus niger hypothetical protein XP_059599977.1 1255853 D 5061 CDS An02g05340 4979023 complement(1258047..1259009) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein 68B2.110 - Neurospora crassa; uncharacterized protein 1259009 4979023 An02g05340 Aspergillus niger uncharacterized protein XP_001399670.1 1258047 R 5061 CDS An02g05350 84590329 join(1259316..1259503,1259580..1259619,1259766..1259799,1259884..1259972) IV 1 NT_166519.1 hypothetical protein 1259972 84590329 An02g05350 Aspergillus niger hypothetical protein XP_059599978.1 1259316 D 5061 CDS An02g05360 4979025 complement(join(1260297..1260404,1260480..1261142)) IV 1 NT_166519.1 Similarity: the predicted A. niger protein shows strong similarity to putative protein 9G6. 360of N. crassa. similarity to other proteins is due to low complexity sequences consisting of threonines.; Title: strong similarity to hypothetical protein 9G6.360 - Neurospora crassa; uncharacterized protein 1261142 4979025 An02g05360 Aspergillus niger uncharacterized protein XP_001399672.1 1260297 R 5061 CDS An02g05370 84590330 complement(join(1261370..1261735,1261975..1262103)) IV 1 NT_166519.1 hypothetical protein 1262103 84590330 An02g05370 Aspergillus niger hypothetical protein XP_059599979.1 1261370 R 5061 CDS An02g05380 4979027 complement(join(1262465..1263961,1264020..1264231,1264514..1264709,1264793..1264870)) IV 1 NT_166519.1 Function: VPS33 of S. cerevisiae is involved in the sorting of vacuolar proteins from the Golgi apparatus and their targeting to the vacuole and that is required for the morphogenesis of vacuoles and subsequent expression of vacuolar functions. VPS33 mutants missort and secrete multiple vacuolar hydrolases and exhibit extreme defects in vacuolar morphology.; Remark: VPS33 of S. cerevisiae is also known as CLS14, MET27, PEP14, SLP1, VAM5, VPL25, VPT33 and has a systematic name of YLR396C.; Similarity: the predicted A. niger protein shows strong similarity to vacuolar protein-sorting protein VPS33 of S. cerevisiae and putative homologues from other species, including a partial C-terminal protein sequence from Aspergillus fumigatus. a partial C-terminal protein sequence (HbrA) from Aspergillus nidulans is covered by patent WO200056893-A1 (AC# AAB29042).; Title: strong similarity to vacuolar protein sorting-associated protein Vps33 - Saccharomyces cerevisiae; cytoplasm; See PMID 2183024; See PMID 2201898; See PMID 3062374; See PMID 3131304; See PMID 3131305; uncharacterized protein 1264870 4979027 An02g05380 Aspergillus niger uncharacterized protein XP_001399674.1 1262465 R 5061 CDS An02g05390 4979028 join(1265425..1266624,1266683..1266742) IV 1 NT_166519.1 Complex: SEC9 of S. cerevisiae is physically associated with two proteins that are homologous to components of the neuronal SNARE complex.; Function: SEC9 of S. cerevisiae is a t-SNARE required for post-Golgi vesicle fusion of secretory vesicles with the plasma membrane.; Localization: SEC9 of S. cerevisiae is bound to the yeast plasma membrane, but absent from post-Golgi vesicles.; Similarity: the predicted A. niger protein shows strong similarity to SEC9 of S. cerevisiae and several synaptosomal proteins like SNAP-25.; Title: strong similarity to t-SNARE Sec9 -Saccharomyces cerevisiae; plasma membrane; uncharacterized protein 1266742 4979028 An02g05390 Aspergillus niger uncharacterized protein XP_001399675.1 1265425 D 5061 CDS An02g05400 4979029 join(1269179..1269188,1269248..1269889,1269968..1272936) IV 1 NT_166519.1 Remark: the 146D nuclear protein of X. laevis is found in the nucleoplasm with high local concentrations during interphase. during mitosis, when transcription and splicing are downregulated, the protein is released from the nuclear speckles and transiently dispersed throughout the cytoplasm.; Remark: the 146D nuclear protein of X. laevis is part of a large particle of approximately 12S.; Similarity: the predicted A. niger protein shows strong similarity to the 146D nuclear protein of X. laevis,human spliceosomal protein SAP 155 and other putative nuclear proteins.; Title: strong similarity to 146D nuclear protein -Xenopus laevis; nucleus; See PMID 9436997; uncharacterized protein 1272936 4979029 An02g05400 Aspergillus niger uncharacterized protein XP_059599980.1 1269179 D 5061 CDS An02g05410 4979030 1273720..1275288 IV 1 NT_166519.1 Catalytic activity: fumarate reductase flavocytochrome c3 (fccA) from S. frigidimarina catalyses the reaction succinate + acceptor <=> fumarate + reduced acceptor.; Cofactor: fumarate reductase flavocytochrome c3 (fccA) from S. frigidimarina is a flavoprotein (FAD) and contains iron-sulfur centres.; Complex: fumarate reductase flavocytochrome c3 (fccA) from S. frigidimarina is a component of succinate dehydrogenase (EC 1. 3. 5. 1).; Pathway: fumarate reductase flavocytochrome c3 (fccA) from S. frigidimarin is involved in the citrate cycle, oxidative phosphorylation, butanoate metabolism and the reductive carboxylate cycle (CO2 fixation).; Remark: Shewanella frigidimarina was formerly named S. putrefaciens.; Similarity: the predicted protein of A. niger shows strong similarity to fumarate reductase flavocytochrome c3 (fccA) from S. frigidimarina and from many other species.; Title: strong similarity to fumarate reductase flavocytochrome c3 fccA - Shewanella frigidimarina; See PMID 10479620; uncharacterized protein 1275288 4979030 An02g05410 Aspergillus niger uncharacterized protein XP_001399677.1 1273720 D 5061 CDS An02g05417 84590331 join(1275705..1275737,1276312..1276710) IV 1 NT_166519.1 hypothetical protein 1276710 84590331 An02g05417 Aspergillus niger hypothetical protein XP_059605140.1 1275705 D 5061 CDS An02g05420 4979032 join(1276871..1277343,1277428..1277915,1277977..1278095) IV 1 NT_166519.1 Similarity: the predicted A. niger protein shows strong similarity to the putative zinc finger protein (flbC) of A. nidulans and similarity to the C2H2 domain of many zinc finger proteins of the Kruppel subfamily.; Title: strong similarity to hypothetical zinc-finger protein flbC - Aspergillus nidulans; uncharacterized protein 1278095 4979032 An02g05420 Aspergillus niger uncharacterized protein XP_001399679.1 1276871 D 5061 CDS An02g05430 84590332 complement(join(1279118..1279197,1279292..1279440,1280052..1280098)) IV 1 NT_166519.1 Title: questionable ORF; uncharacterized protein 1280098 84590332 An02g05430 Aspergillus niger uncharacterized protein XP_059605141.1 1279118 R 5061 CDS An02g05440 4979034 complement(join(1280589..1281051,1281107..1281823,1281872..1282409,1282460..1282546,1282599..1282946,1283001..1283868)) IV 1 NT_166519.1 Similarity: the predicted A. niger protein shows also similarity to the C-termini of hypothetical proteins from M. musculus and H. sapiens.; Title: similarity to hypothetical protein Leucine-rich protein - Schizosaccharomyces pombe; uncharacterized protein 1283868 4979034 An02g05440 Aspergillus niger uncharacterized protein XP_001399681.1 1280589 R 5061 CDS An02g05450 4979035 join(1284250..1284278,1284326..1284427,1284550..1284629,1284678..1284974,1285029..1285780) IV 1 NT_166519.1 Complex: human hUba3 forms a complex with APP-BP1 (amyloid precursor protein-binding protein) which behaves like the ubiquitin activating enzyme E1 in a novel ubiquitinylation-related pathway involving the ubiquitin-like molecule NEDD8. hUba3 contains the active cysteine and ATP binding site.; Function: expression of human APP-BP1 in ts41 cells drives the cell cycle through the S-M checkpoint and this function requires both hUba3 and hUbc12 (a human homolog of yeast Ub-conjugating enzyme Ubc12p).; Remark: the protein sequence of human hUba3, here named NAE1-beta protein, is covered by patent WO9932624-A1 (AC# AAY25339).; Remark: ubiquitin (ub) and ubiquitin-like proteins (i. e. human NEDD8) are ligated to proteins by a protein system consisting of E1- (Ub-activating), E2-like (Ub-conjugating) enzymes and E3 (Ub-ligating) enzymes. the covalent attachment of ubiquitin to other proteins mediates the selective degradation of short-lived and abnormal proteins.; Title: strong similarity to Nedd8-activating enzyme hUba3 - Homo sapiens; See PMID 9694792; See PMID 10722740; uncharacterized protein 1285780 4979035 An02g05450 Aspergillus niger uncharacterized protein XP_059605142.1 1284250 D 5061 CDS An02g05460 4979036 complement(join(1286043..1286285,1286328..1287014,1287113..1287217,1287294..1287338)) IV 1 NT_166519.1 Complex: RCP40 of S. cerevisiae associates with RCP19 of S. cerevisiae, another subunit shared only by RNAP I and RNAP III. The RCP19/RCP40 heterodimer interacts with the ABC10 beta subunit (encoded by RPB10) of S. cerevisiae, which is one of the five polypeptides common to all three nuclear RNA polymerases.; Complex: RCP40 of S. cerevisiae is a subunit of RNA polymerases I(A) (RNAP I) and III(C) (RNAP III), but not RNA polymerase II.; Remark: RCP40 of S. cerevisiae is also called AC40,RPC5, YPR110C or P8283. 18.; Remark: RCP40 of S. cerevisiae is unique in the yeast genome and is required for cell viability.; Similarity: the predicted A. niger protein shows strong similarity to RPC40, a subunit of RNA polymerase I and III from S. cerevisiae and many other eucaryotic organisms. RCP40 of S. cerevisiae shows a local sequence similarity to prokaryotic alpha subunits.; Title: strong similarity to 40 kD subunit of DNA-directed RNA polymerase I,III Rpc40 - Saccharomyces cerevisiae; nucleus; See PMID 8516295; See PMID 3815519; uncharacterized protein 1287338 4979036 An02g05460 Aspergillus niger uncharacterized protein XP_059605143.1 1286043 R 5061 CDS An02g05470 4979037 join(1287768..1288439,1288507..1289227,1289287..1289324) IV 1 NT_166519.1 Catalytic activity: NADH:ubiquinone oxidoreductase catalyses the reaction NADH + ubiquinone = NADH(+) + ubiquinol.; Cofactor: NADH:ubiquinone oxidoreductase requires iron-sulfur as a cofactor.; Complex: the 49 kd subunit from N. crassa is a component of the iron-sulphur subcomplex of the enzyme.; Function: the proton-pumping NADH:ubiquinone oxidoreductase is the first of the respiratory chain complexes in many bacteria and mitochondria of most eukaryotes. NADH:ubiquinone oxidoreductase transfers electrons from NADH to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.; Localization: NADH:ubiquinone oxidoreductase is located on the matrix side of the mitochondrial inner membrane.; Remark: the mitochondrial NADH-ubiquinone reductase (complex I) is an assembly of approximately 30 different polypeptides. the 49 kd subunit from N. crassa is a nuclear gene product, that is imported into the mitochondria.; Similarity: the predicted A. niger protein shows strong similarity to the mitochondrial 49 K subunit of NADH: ubiquinone reductase (complex I) from N. crassa and many other eucaryotic and procaryotic organisms.; Title: strong similarity to 49 kD subunit of NADH:ubiquinone reductase - Neurospora crassa; localisation:mitochondrion; See PMID 11004444; See PMID 2147127; uncharacterized protein 1289324 4979037 An02g05470 Aspergillus niger uncharacterized protein XP_001399684.1 1287768 D 5061 CDS An02g05480 4979038 complement(join(1290201..1290484,1290581..1290731,1290941..1290967)) IV 1 NT_166519.1 Function: the protein encoded by UBC2-1 from A. thaliana is shown to accept 125I-ubiquitin from wheat E1 enzymes, when expressed from E. coli hosts as fusion protein carrying N-terminal extensions. UBC2-1 is deubiquitinated in the presence of lysine and, by these criteria, is considered a functional E2 enzyme.; Remark: ubiquitin (ub) and ubiquitin-like proteins are ligated to proteins by a protein system consisting of E1- (Ub-activating), E2-like (Ub-conjugating) enzymes and E3 (Ub-ligating) enzymes. the covalent attachment of ubiquitin to other proteins mediates the selective degradation of short-lived and abnormal proteins.; Remark: ubiquitin is coupled to protein by a peptide bond between the C-terminal glycine of ubiquitin and epsilon-amino groups of lysine residues in the protein. an intermediate in the reaction contains one ubiquitin residue bound as a thiolester to the enzyme, and a residue of ubiquitin adenylate non-covalently bound to the enzyme.; Title: strong similarity to ubiquitin conjugating enzyme UBC2 - Arabidopsis thaliana; See PMID 8219072; uncharacterized protein 1290967 4979038 An02g05480 Aspergillus niger uncharacterized protein XP_059605144.1 1290201 R 5061 CDS An02g05490 4979039 complement(join(1291756..1292558,1292629..1292785,1292838..1293045,1293117..1293168,1293554..1293560)) IV 1 NT_166519.1 Catalytic activity: CMK2 of S. cerevisiae catalyses the reaction ATP + protein = ADP + O-phosphoprotein.; Cofactor: CMK2 of S. cerevisiae needs Ca2+/calmodulin as a cofactor.; Remark: CMK1 and CMK2 of S. cerevisiae were found to have different biochemical properties in terms of autoregulatory activity and preference for yeast CaM or bovine CaM for maximal activity.; Remark: mutant S. cerevisiae cells with deletion of CMK2, or both CMK1 and CMK2, are viable, although loss of CMK2 causes a slow rate of spore germination.; Similarity: the predicted A. niger protein shows strong similarity to Ca2+/calmodulin-dependent protein kinase (CMK2) from S. cerevisiae and many other eucaryotic organisms. in S. cerevisiae, there are two known Ca2+/calmodulin-dependent protein kinases, CMK1 and CMK2.; Title: strong similarity to Ca(2+)/calmodulin-dependent protein kinase Cmk2 -Saccharomyces cerevisiae; See PMID 2026147; See PMID 2061341; uncharacterized protein 1293560 4979039 An02g05490 Aspergillus niger uncharacterized protein XP_001399686.1 1291756 R 5061 CDS An02g05510 84590333 join(1293972..1294060,1294251..1294353) IV 1 NT_166519.1 hypothetical protein 1294353 84590333 An02g05510 Aspergillus niger hypothetical protein XP_059605145.1 1293972 D 5061 CDS An02g05520 4979041 complement(join(1294953..1295066,1295108..1295177,1295339..1296180)) IV 1 NT_166519.1 hypothetical protein 1296180 4979041 An02g05520 Aspergillus niger hypothetical protein XP_001399688.3 1294953 R 5061 CDS An02g05530 4979042 complement(join(1297227..1299074,1299122..1299291,1299340..1299454,1299532..1300853,1300905..1300975,1301024..1301067)) IV 1 NT_166519.1 Function: severin kinase is a kinase from cytosolic extracts that specifically phosphorylates severin, a Ca2+-dependent F-actin fragmenting protein.; Pathway: the presence of severin kinase in Dictyostelium suggests a direct signal transduction from the plasma membrane to the cytoskeleton by phosphorylation of actin-binding proteins.; Similarity: the central part of the predicted A. niger protein shows strong similarity to severin kinase from D. discoideum and (mostly hypothetical) kinases from diverse eucaryotic species, that belong to the Ste20p- or p21-activated protein kinase family.; Title: similarity to severin kinase - Dictyostelium discoideum; cytoplasm; See PMID 9582328; uncharacterized protein 1301067 4979042 An02g05530 Aspergillus niger uncharacterized protein XP_001399689.1 1297227 R 5061 CDS An02g05540 4979043 complement(join(1302719..1302973,1303035..1303859,1303919..1303995,1304052..1304262,1304320..1304351,1304402..1304438,1304518..1304679)) IV 1 NT_166519.1 Catalytic activity: kynurenine/alpha-aminoadipate aminotransferase of R. norvegicus catalyses the reaction L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate and the reaction L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate.; Cofactor: kynurenine/alpha-aminoadipate aminotransferase of R. norvegicus needs pyridoxal-phosphate as a co-factor.; Function: kynurenine aminotransferase catalyses the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid, which is thought to be an endogenous modulator of glutamatergic neurotransmission.; Similarity: the predicted A. niger protein shows strong similarity to kynurenine/alpha-aminoadipate aminotransferase of R. norvegicus, but also to probable valine-pyruvate transaminase of S. pombe.; Title: strong similarity to kynurenine/alpha-aminoadipate aminotransferase - Rattus norvegicus; cytoplasm; See PMID 7493966; uncharacterized protein 1304679 4979043 An02g05540 Aspergillus niger uncharacterized protein XP_001399690.1 1302719 R 5061 CDS An02g05550 84590334 join(1304818..1304855,1304929..1305105,1305273..1305423) IV 1 NT_166519.1 hypothetical protein 1305423 84590334 An02g05550 Aspergillus niger hypothetical protein XP_059605146.1 1304818 D 5061 CDS An02g05560 4979045 1306817..1307881 IV 1 NT_166519.1 Catalytic activity: 2,3-dihydroxybenzoic acid decarboxylase of A. niger catalyses the reaction 2,3-dihydroxybenzoate = catechol + CO(2).; Complex: 2,3-dihydroxybenzoic acid decarboxylase is a homotetramer.; Pathway: 2,3-dihydroxybenzoic acid decarboxylase of A. niger catalyses the last step in the metabolism of indole to catechol.; Remark: the products of the invention can be used in a method to produce aromatic hydrocarbons, particularly catechol which is used in the development of pharmaceuticals such as L-DOPA and adrenaline,agrobiochemicals such as carbofuran, and antioxidants such as 4-tert-butyl catechol and veratol. unlike the invention,prior art aromatic hydrocarbon production methods involve the use of non-renewable resources, have a negative impact on the environment, and involve high temperatures and acid conditions which pose environmental and safety concerns,are expensive and are energy consuming.; Similarity: the predicted A. niger protein shows strong similarity, but not identity, to the protein sequence 2,3-dihydroxybenzoic acid decarboxylase of patent WO9909048-A1 of A. niger (AC# AAW93483).; Title: strong similarity to 2,3-dihydroxybenzoic acid decarboxylase from patent WO9909048-A1 - Aspergillus niger; cytoplasm; uncharacterized protein 1307881 4979045 An02g05560 Aspergillus niger uncharacterized protein XP_001399692.1 1306817 D 5061 CDS An02g05570 84590335 complement(join(1308348..1308396,1308484..1308948,1309159..1309166)) IV 1 NT_166519.1 Title: weak similarity to hypothetical protein encoded by An17g00640 - Aspergillus niger; uncharacterized protein 1309166 84590335 An02g05570 Aspergillus niger uncharacterized protein XP_059605147.1 1308348 R 5061 CDS An02g05580 84590336 join(1309336..1309541,1309573..1309897) IV 1 NT_166519.1 hypothetical protein 1309897 84590336 An02g05580 Aspergillus niger hypothetical protein XP_059605148.1 1309336 D 5061 CDS An02g05590 4979048 complement(join(1310622..1310667,1310757..1312366,1312434..1312646,1312712..1312870,1313211..1313264)) IV 1 NT_166519.1 Catalytic activity: benzoylformate decarboxylase of P. putida catalyses the reaction benzoylformate = benzaldehyde + CO(2); Cofactor: benzoylformate decarboxylase of P. putida requires thiamine pyrophosphate as a cofactor.; Pathway: benzoylformate decarboxylase of P. putida is one of the five known enzymes of the mandelate pathway.; Remark: the genes for (S)-mandelate dehydrogenase,benzoylformate decarboxylase and mandelate racemase of P. putida are organized in an operon (mdlCBA).; Title: similarity to benzoylformate decarboxylase -Pseudomonas putida; cytoplasm; See PMID 2271624; uncharacterized protein 1313264 4979048 An02g05590 Aspergillus niger uncharacterized protein XP_059605149.1 1310622 R 5061 CDS An02g05600 4979049 join(1313622..1313858,1313920..1314736,1314795..1315660) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein CAD70734.1 - Neurospora crassa; uncharacterized protein 1315660 4979049 An02g05600 Aspergillus niger uncharacterized protein XP_059605150.1 1313622 D 5061 CDS An02g05610 4979050 complement(join(1316551..1316968,1317068..1317757,1317817..1317952,1318023..1318044)) IV 1 NT_166519.1 Catalytic activity: branched-chain alpha-ketoacid dehydrogenase kinase of R. norvegicus catalyzes the reaction ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] = ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate.; Complex: mammalian mitochondrial branched-chain alpha-ketoacid dehydrogenase complex consists of three catalytic components: E1 (a heterotetrameric thiamine pyrophosphate-dependent decarboxylase), E2 (a 24-mer of identical lipoate-bearing proteins), E3 (a dimeric dehydrogenase) and two regulatory enzymes, a specific kinase (branched-chain alpha-ketoacid dehydrogenase kinase) and a specific phosphatase, which control enzyme activity by reversible phosphorylation/dephosphorylation.; Function: branched-chain alpha-ketoacid dehydrogenase kinase of R. norvegicus catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways.; Remark: alpha-chloroisocaproate and dichloroacetate inhibit branched-chain alpha-ketoacid dehydrogenase kinase of R. norvegicus; Similarity: the predicted A. niger protein shows strong similarity to branched-chain alpha-ketoacid dehydrogenase kinase (BCKDK) from R. norvegicus, which belongs to the PDK(pyruvate dehydrogenase kinase)/BCKDK family of protein kinases.; Title: strong similarity to branched-chain alpha-ketoacid dehydrogenase kinase BCKDK - Rattus norvegicus; localisation:mitochondrion; uncharacterized protein 1318044 4979050 An02g05610 Aspergillus niger uncharacterized protein XP_059605151.1 1316551 R 5061 CDS An02g05620 4979051 join(1318536..1318553,1318613..1318653,1318713..1318781,1318845..1318932) IV 1 NT_166519.1 Similarity: the predicted A. niger protein shows strong similarity to the five ESTs an_2860, an_2570,an_2857, AN06C0 and an_2883 of A. niger.; Similarity: the predicted A. niger protein shows weak similarity to the hypothetical protein YHR138c from S. cerevisiae, which is similar to yeast protease B inhibitor 2 (PBI2).; Title: weak similarity to hypothetical protein encoded by An07g10060 - Aspergillus niger; uncharacterized protein 1318932 4979051 An02g05620 Aspergillus niger uncharacterized protein XP_001399698.1 1318536 D 5061 CDS An02g05630 4979052 complement(join(1319451..1320440,1320489..1320635,1320681..1321445,1321491..1321751,1321806..1322006)) IV 1 NT_166519.1 Induction: the N. crassa HAK1 transporter is only expressed when cells are K+ starved.; Remark: the N. crassa HAK1 transporter expressed by the corresponding cDNAs in a trk1 delta trk2 delta mutant of S. cerevisiae exhibits a high affinity for Rb+ and K+.; Remark: the N. crassa HAK1 transporter shows a high concentrative capacity and is the K(+)-H+ symporter described in N. crassa.; Title: strong similarity to potassium transporter hak-1 - Neurospora crassa; plasma membrane; See PMID 10027968; uncharacterized protein 1322006 4979052 An02g05630 Aspergillus niger uncharacterized protein XP_001399699.3 1319451 R 5061 CDS An02g05640 4979053 complement(join(1323492..1323691,1323743..1324048,1324103..1324478)) IV 1 NT_166519.1 Similarity: the predicted A. niger protein shows strong similarity to the hypothetical protein SPAC11D3. 03c from S. pombe and also strong similarity to the hypothetical protein CG10208 of D. melanogaster, but only weak similarity to hypothetical proteins from several procaryotic organisms.; Title: strong similarity to hypothetical protein SPAC11D3.03c - Schizosaccharomyces pombe; uncharacterized protein 1324478 4979053 An02g05640 Aspergillus niger uncharacterized protein XP_059605152.1 1323492 R 5061 CDS An02g05650 4979054 join(1325058..1325115,1325189..1325259,1325326..1325415,1325482..1328805) IV 1 NT_166519.1 Remark: the N-terminus of the human protein sequence is covered by patent WO200073801-A2 (AC# AAB63577).; Similarity: the predicted A. niger protein shows strong similarity to the hypothetical protein YPL217c from S. cerevisiae and also strong similarity to hypothetical proteins from several eucaryotic organisms.; Title: strong similarity to hypothetical protein YPL217c - Saccharomyces cerevisiae; uncharacterized protein 1328805 4979054 An02g05650 Aspergillus niger uncharacterized protein XP_001399701.1 1325058 D 5061 CDS An02g05660 4979055 join(1328987..1329015,1329194..1329347,1329623..1330288,1330394..1331270,1331358..1331635) IV 1 NT_166519.1 hypothetical protein 1331635 4979055 An02g05660 Aspergillus niger hypothetical protein XP_059605153.1 1328987 D 5061 CDS An02g05670 4979056 1331770..1332384 IV 1 NT_166519.1 Catalytic activity: lactoylglutathione lyase (glyoxalase-I) of L. esculentum catalyses the reaction (R)-S-lactoylglutathione = glutathione + methylglyoxal.; Cofactor: glyoxalase-I of L. esculentum contains zinc (by similarity).; Function: glyoxalase-I of L. esculentum catalyses the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (by similarity) and thus may serve to detoxify methylglyoxal produced from triosephosphates in all cells.; Induction: glyoxalase-I of L. esculentum is induced by salt-stress.; Pathway: glyoxalase-I of L. esculentum belongs to the glyoxal pathway.; Similarity: the predicted A. niger protein shows similarity to lactoylglutathione lyase (glyoxalase-I) of L. esculentum, which belongs to the glyoxalase I family.; Title: similarity to lactoylglutathione lyase glyoxalase-I - Lycopersicon esculentum; See PMID 8616220; uncharacterized protein 1332384 4979056 An02g05670 Aspergillus niger uncharacterized protein XP_001399703.3 1331770 D 5061 CDS An02g05680 4979057 join(1333496..1333564,1333633..1334349) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein EAA62513.1 - Aspergillus nidulans; uncharacterized protein 1334349 4979057 An02g05680 Aspergillus niger uncharacterized protein XP_001399704.3 1333496 D 5061 CDS An02g05690 4979058 complement(join(1335301..1335654,1335719..1336731,1336794..1337438,1337511..1337629,1337714..1337778)) IV 1 NT_166519.1 Title: similarity to hypothetical coiled-coil protein - Schizosaccharomyces pombe; uncharacterized protein 1337778 4979058 An02g05690 Aspergillus niger uncharacterized protein XP_001399705.1 1335301 R 5061 CDS An02g05700 4979059 complement(join(1338494..1338511,1338575..1340353,1340410..1341065,1341144..1341201,1341330..1341345,1341485..1341492)) IV 1 NT_166519.1 Function: eEF-2 of C. griseus promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome.; Remark: eEF-2 of C. griseus is completely inactivated by phosphorylation mediated by EF-2 kinase.; Similarity: the predicted A. niger protein shows strong similarity to GTP-binding translation elongation factor eEF-2 of C. griseus, which belongs to the EF-G/EF-2 family.; Title: strong similarity to translation elongation factor eEF-2 - Cricetulus griseus; cytoplasm; uncharacterized protein 1341492 4979059 An02g05700 Aspergillus niger uncharacterized protein XP_001399706.1 1338494 R 5061 CDS An02g05710 84590337 join(1341961..1341976,1342093..1342130,1342224..1342311,1342402..1342497,1342593..1342794,1342907..1343039) IV 1 NT_166519.1 hypothetical protein 1343039 84590337 An02g05710 Aspergillus niger hypothetical protein XP_059605154.1 1341961 D 5061 CDS An02g05720 84590338 complement(join(1343650..1343919,1344160..1344252)) IV 1 NT_166519.1 hypothetical protein 1344252 84590338 An02g05720 Aspergillus niger hypothetical protein XP_059605155.1 1343650 R 5061 CDS An02g05730 4979062 join(1344920..1345088,1345237..1346271,1346322..1346592,1346643..1346715) IV 1 NT_166519.1 Catalytic activity: cellulose synthase of A. xylinum catalyses the reaction UDP-glucose + {(1,4)-beta-D-glucosyl}(N) = UDP + {(1,4)-beta-D-glucosyl}(N+1).; Pathway: cellulose synthase of A. xylinum is involved in the synthesis of cellulose.; Remark: cellulose synthase of A. xylinum is the second protein encoded by the cellulose biosynthesis (bcs) operon.; Title: similarity to cellulose synthase protein bcsB - Acetobacter xylinum; See PMID 2146681; See PMID 2151718; uncharacterized protein 1346715 4979062 An02g05730 Aspergillus niger uncharacterized protein XP_059605156.1 1344920 D 5061 CDS An02g05740 4979063 complement(join(1347406..1357034,1357157..1357181)) IV 1 NT_166519.1 Title: strong similarity to hypothetical membrane protein YLR087c - Saccharomyces cerevisiae; uncharacterized protein 1357181 4979063 An02g05740 Aspergillus niger uncharacterized protein XP_059605157.1 1347406 R 5061 CDS An02g05750 4979064 join(1357760..1357854,1358022..1358075,1358131..1358218,1358272..1359285,1359343..1359701,1359771..1359948) IV 1 NT_166519.1 Similarity: the ORF overlpas with A. niger EST an_1043 entry EMBLEST:BE760156.; Similarity: the predicted ORF is 162 amino acids longer at the C-terminus than the hypothetical protein SPAC30D11. 06c of S. pombe.; Title: strong similarity to hypothetical protein SPAC30D11.06c - Schizosaccharomyces pombe; uncharacterized protein 1359948 4979064 An02g05750 Aspergillus niger uncharacterized protein XP_059605158.1 1357760 D 5061 CDS An02g05760 4979065 join(1360876..1360996,1361072..1362366) IV 1 NT_166519.1 Remark: glucan 1,4-alpha-glucosidase of S. cerevisiae has the EC number 3. 2. 1. 3.; Remark: the ORF shows strong similarity to EST an_3103 of A. niger. It has the database entry number EMBLEST:BE758851.; Similarity: additionally, the ORF overlaps with A. niger EST entry EMBLEST:BE759644.; Similarity: the blastp hits are mostly unspecific.; Title: weak similarity to glucan 1,4-alpha-glucosidase Muc1 - Saccharomyces cerevisiae; uncharacterized protein 1362366 4979065 An02g05760 Aspergillus niger uncharacterized protein XP_001399712.3 1360876 D 5061 CDS An02g05770 84590339 complement(join(1363032..1363247,1363331..1363605,1363709..1363770,1363859..1363926,1364043..1364111)) IV 1 NT_166519.1 hypothetical protein 1364111 84590339 An02g05770 Aspergillus niger hypothetical protein XP_059605159.1 1363032 R 5061 CDS An02g05780 84590340 complement(join(1364285..1364449,1364490..1364606)) IV 1 NT_166519.1 hypothetical protein 1364606 84590340 An02g05780 Aspergillus niger hypothetical protein XP_059605160.1 1364285 R 5061 CDS An02g05790 4979068 join(1364712..1364831,1364894..1365400) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein encoded by An09g03310 - Aspergillus niger; uncharacterized protein 1365400 4979068 An02g05790 Aspergillus niger uncharacterized protein XP_059605161.1 1364712 D 5061 CDS An02g05800 84590341 join(1365765..1365892,1365952..1366225) IV 1 NT_166519.1 hypothetical protein 1366225 84590341 An02g05800 Aspergillus niger hypothetical protein XP_059605162.1 1365765 D 5061 CDS An02g05810 84590342 join(1366349..1366476,1366519..1366636) IV 1 NT_166519.1 Remark: the ORF is questionable due to its short lenght of only 81 amino acids.; Title: questionable ORF; uncharacterized protein 1366636 84590342 An02g05810 Aspergillus niger uncharacterized protein XP_059605163.1 1366349 D 5061 CDS An02g05820 84590343 complement(join(1366668..1366784,1366832..1366933)) IV 1 NT_166519.1 Remark: the ORF is questionable due to its short lenght of only 72 amino acids.; Title: questionable ORF; uncharacterized protein 1366933 84590343 An02g05820 Aspergillus niger uncharacterized protein XP_059605164.1 1366668 R 5061 CDS An02g05830 4979072 1367024..1368190 IV 1 NT_166519.1 Catalytic activity: mannitol-1-phosphate 5-dehydrogenases convert D-mannitol 1-phosphate + NAD(+) <=> D-fructose 6-phosphate + NADH.; Function: mannitol-1-phosphate 5-dehydrogenase mtlD of S. mutans is acting as part of the phosphoenolpyruvate-dependent phosphotransferase system (PTS), which facilitates the vectorial translocation of metabolisable carbohydrates to form the corresponding sugar phosphates, which are then converted to glycolytic intermediates.; Similarity: the ORF shows a weak homologues overlap with A. niger EST entry EMBLEST:BE760637 and strong similarity to PATENTDNA:AAF11255 EST SEQ ID NO:3778 as well as with PATENTDNA:AAF11568 EST SEQ ID NO:4091.; Title: strong similarity to mannitol-1-phosphate 5-dehydrogenase mtlD - Streptococcus mutans; See PMID 10878121; uncharacterized protein 1368190 4979072 An02g05830 Aspergillus niger uncharacterized protein XP_001399719.1 1367024 D 5061 CDS An02g05840 4979073 complement(join(1368503..1369107,1369213..1369441)) IV 1 NT_166519.1 Catalytic activity: phaA of P. putida catalyses (3S)-3-hydroxyacyl-CoA <=> trans-2(or 3)-enoyl-CoA + H(2)O.; Function: phaA of P. putida is involved in the the aerobic degradation of phenylacetic acid.; Title: strong similarity to enoyl CoA hydratase phaA - Pseudomonas putida; uncharacterized protein 1369441 4979073 An02g05840 Aspergillus niger uncharacterized protein XP_001399720.1 1368503 R 5061 CDS An02g05850 4979074 complement(join(1370023..1371474,1371551..1371643)) IV 1 NT_166519.1 Function: ada2 of S. cerevisiae functions as adaptor for some transcriptional activation domains and thereby facilitates activation, probably by potentiating the activity of the transcriptional activator complex GAL4-VP16.; Phenotype: mutations in ada2 of S. cerevisiae reduced the activity of GAL4-VP16 and GCN4.; Remark: ada2 of S. cerevisiae is also called YDR448W, D9461. 33 or SWI8.; Title: strong similarity to transcription adaptor Ada2 - Saccharomyces cerevisiae; nucleus; See PMID 10490601; uncharacterized protein 1371643 4979074 An02g05850 Aspergillus niger uncharacterized protein XP_001399721.3 1370023 R 5061 CDS An02g05860 4979075 join(1372857..1372878,1372959..1373102,1373166..1374317,1374369..1374733,1374791..1374988) IV 1 NT_166519.1 Function: dagA of D. discoideum is required for receptor and G protein-mediated activation of adenylyl cyclase.; Similarity: the ORF shows similarity to several serine/threonine protein kinases from different species with various function.; Title: strong similarity to rac-family serine/threonine protein kinase homolog dagA -Dictyostelium discoideum; deleted EC_number 2.7.1.37; uncharacterized protein 1374988 4979075 An02g05860 Aspergillus niger uncharacterized protein XP_001399722.1 1372857 D 5061 CDS An02g05870 4979076 complement(join(<1376204..1377422,1377478..1378746,1378804..1378835,1378895..1378916,1378966..1379028,1379145..1379162)) IV 1 NT_166519.1 Function: coatomer beta' subunit copB2 (p102) of H. sapiens is part of the Golgi coatomer complex necessary for membrane traffic in the constitutive exocytic pathway and retro-Golgi to ER transport by facilitating the formation of non-clathrin coated vesicles.; Remark: a putative frameshift due to an possible error at position 23672 (one bp too much) was corrected.; Title: strong similarity to coatomer beta subunit copB2 - Homo sapiens [putative frameshift]; cytoplasm; putative frameshift; See PMID 8334999; uncharacterized protein 1379162 4979076 An02g05870 Aspergillus niger uncharacterized protein XP_059603390.1 1376204 R 5061 CDS An02g05880 4979077 complement(join(1379852..1379918,1379976..1380080,1380143..1380684)) IV 1 NT_166519.1 Catalytic activity: the NADH dehydrogenase from N. crassa converts NADH + ubiquinone <=> NAD(+) + ubiquinol.; Function: subunit of the bioenergetic enzyme complex NADH:ubiquinone reductase, which is involved in electron transfer from NADH to ubiquinone in the respiratory chain.; Induction: the level of the corresponding mRNA of the NADH dehydrogenase from N. crassa is increased 3-fold if cells are grown in the presence of chloramphenicol.; Similarity: the ORF overlaps with A. niger EST entry in PATENTDNA:AAF11473 EST SEQ ID NO:3996.; Title: strong similarity to 29.9 kD subunit of NADH:ubiquinone reductase - Neurospora crassa; localisation:mitochondrion; See PMID 1830489; uncharacterized protein 1380684 4979077 An02g05880 Aspergillus niger uncharacterized protein XP_001399724.1 1379852 R 5061 CDS An02g05890 4979078 join(1381234..1381454,1381516..1381597,1381667..1383196,1383258..1383620) IV 1 NT_166519.1 Complex: protein disulfate isomerases are part of variuos enzymes with different functions, e. g. are active as beta subunit of prolyl 4-hydroxylases.; Function: pdi1 of C. elegans is facilitating the rearrangement of both intrachain and interchain disulfide bonds in proteins to form the native structures from maturating protein chains.; Similarity: the ORF show similarity to several protein disulfide-isomerases from different species.; Title: strong similarity to protein disulfide-isomerase pdi1 - Caenorhabditis elegans; endoplasmatic reticulum; uncharacterized protein 1383620 4979078 An02g05890 Aspergillus niger uncharacterized protein XP_001399725.1 1381234 D 5061 CDS An02g05900 4979079 join(1384197..1384199,1384556..1384634,1384704..1384987,1385062..1385070) IV 1 NT_166519.1 Similarity: the ORF shows strong similarity to A. niger EST PATENTDNA: AAF11580 SEQ ID NO:4103.; Title: similarity to hypothetical protein AA57718.1 - Aspergillus nidulans; uncharacterized protein 1385070 4979079 An02g05900 Aspergillus niger uncharacterized protein XP_059603391.1 1384197 D 5061 CDS An02g05910 84590344 join(1385326..1385580,1385725..1385754,1386084..1386338) IV 1 NT_166519.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF; uncharacterized protein 1386338 84590344 An02g05910 Aspergillus niger uncharacterized protein XP_059603392.1 1385326 D 5061 CDS An02g05920 4979081 join(1386845..1387100,1387153..1387264,1387316..1388642) IV 1 NT_166519.1 Function: uga4 of S. cerevisiae additionally transports delta-aminolevulinic acid (ALA), another precursor of the porphyrin biosynthesis.; Function: uga4 of S. cerevisiae is the specific GABA transport protein of the yeast, in which additionally the amino acid permease (GAP1 gene) and the proline permease (PUT4 gene) exist.; Induction: the presence of GABA induces the expression of uga4 in S. cerevisiae; this induction is conferred by the 5' flanking region and requires the integrity of two positive regulatory proteins, the inducer-specific factor UGA3 and the pleiotropic factor UGA35/DURL/DAL81.; Remark: uga4 of S. cerevisiae is also called YDL210W or D1037.; Similarity: the ORF shows strong similarity to specialized amino acid and GABA transporters from several species, which belong both to the superfamily of choline transport proteins.; Title: strong similarity to GABA permease Uga4 -Saccharomyces cerevisiae; plasma membrane; See PMID 2109179; See PMID 10713424; uncharacterized protein 1388642 4979081 An02g05920 Aspergillus niger uncharacterized protein XP_001399728.1 1386845 D 5061 CDS An02g05930 4979082 join(1389219..1389398,1389442..1390354,1390414..1390466,1390517..1390558) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein encoded by An16g01290 - Aspergillus niger; uncharacterized protein 1390558 4979082 An02g05930 Aspergillus niger uncharacterized protein XP_059603393.1 1389219 D 5061 CDS An02g05940 84590345 join(1392210..1392267,1392360..1392490,1392578..1392622,1392676..1392774) IV 1 NT_166519.1 hypothetical protein 1392774 84590345 An02g05940 Aspergillus niger hypothetical protein XP_059603394.1 1392210 D 5061 CDS An02g05950 84590346 complement(join(1392822..1392871,1392984..1393131,1393171..1393323,1393500..1393631)) IV 1 NT_166519.1 hypothetical protein 1393631 84590346 An02g05950 Aspergillus niger hypothetical protein XP_059603395.1 1392822 R 5061 CDS An02g05960 84590347 complement(join(1394058..1394249,1394365..1394655,1394727..1394741)) IV 1 NT_166519.1 hypothetical protein 1394741 84590347 An02g05960 Aspergillus niger hypothetical protein XP_059603396.1 1394058 R 5061 CDS An02g05970 84590348 complement(join(1395863..1396001,1396048..1396410,1396500..1396548,1396623..1396718,1396815..1396871,1396971..1396998)) IV 1 NT_166519.1 hypothetical protein 1396998 84590348 An02g05970 Aspergillus niger hypothetical protein XP_059603397.1 1395863 R 5061 CDS An02g05980 84590349 complement(join(1397310..1397437,1397481..1397608,1397693..1397761,1397898..1398002,1398070..1398526,1398618..1398667,1398716..1398850,1398969..1399076,1399396..1399460)) IV 1 NT_166519.1 hypothetical protein 1399460 84590349 An02g05980 Aspergillus niger hypothetical protein XP_059603398.1 1397310 R 5061 CDS An02g05990 84590350 complement(join(1399561..1399680,1399772..1400212,1400285..1400368)) IV 1 NT_166519.1 hypothetical protein 1400368 84590350 An02g05990 Aspergillus niger hypothetical protein XP_059603399.1 1399561 R 5061 CDS An02g06000 4979089 join(1400652..1401156,1401246..1402010,1402262..1402434) IV 1 NT_166519.1 Title: strong similarity to gene expression regulator protein SEQ ID NO:119 from patent WO200257456-A2 - Unclassified organism; nucleus; uncharacterized protein 1402434 4979089 An02g06000 Aspergillus niger uncharacterized protein XP_059599981.1 1400652 D 5061 CDS An02g06010 4979090 1404695..1405303 IV 1 NT_166519.1 Title: weak similarity to protein CARD-6 from patent WO200100826-A2 - Homo sapiens; uncharacterized protein 1405303 4979090 An02g06010 Aspergillus niger uncharacterized protein XP_001399737.1 1404695 D 5061 CDS An02g06020 4979091 complement(join(1406031..1407355,1407413..1407470,1407518..1407538,1407585..1407686)) IV 1 NT_166519.1 Similarity: the ORF show much weaker similarity to several tetracycline efflux pumps from different species.; Title: strong similarity to hypothetical amine transporter SPCC18.02 - Schizosaccharomyces pombe; uncharacterized protein 1407686 4979091 An02g06020 Aspergillus niger uncharacterized protein XP_059599982.1 1406031 R 5061 CDS An02g06030 4979092 join(1408400..1408539,1408596..1409242,1409308..1409429) IV 1 NT_166519.1 Catalytic activity: uaz of A. flavus converts urate + O(2) + H(2)O <=> 5-hydroxyxyisourate + H(2)O(2), and 5-hydroxyisourate decompose autocatalytically to form allantoin.; Function: uricase (urate oxidase) is the peroxisomal enzyme responsible for the degradation of the purine ring in urate into allantoin.; Remark: uaz of A. flavus is also called uox.; Title: strong similarity to urate oxidase uaz -Aspergillus flavus; peroxisome; See PMID 1339455; uncharacterized protein 1409429 4979092 An02g06030 Aspergillus niger uncharacterized protein XP_001399739.1 1408400 D 5061 CDS An02g06040 4979093 complement(join(1409778..1409896,1410029..1410389,1410512..1410532)) IV 1 NT_166519.1 Similarity: the ORF shows also strong similarity to several ribosomal proteins L13 from different species with mitochondrial and cytoplasmic localization, which belongs to the same superfamily as L23, to the L13 family of ribosomal proteins.; Title: strong similarity to mitochondrial ribosomal protein of the large subunit L23 - Kluyveromyces lactis; See PMID 10743564; mitochondrial 54S ribosomal protein uL13m 1410532 4979093 An02g06040 Aspergillus niger mitochondrial 54S ribosomal protein uL13m XP_001399740.1 1409778 R 5061 CDS An02g06050 4979094 join(1410880..1410925,1411037..1411059,1411441..1411512,1411587..1411877) IV 1 NT_166519.1 Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S16.e - Saccharomyces cerevisiae; cytoplasm; See PMID 1544921; 40S ribosomal protein uS9 1411877 4979094 An02g06050 Aspergillus niger 40S ribosomal protein uS9 XP_001399741.1 1410880 D 5061 CDS An02g06060 4979095 complement(join(1412818..1413303,1413352..1413822,1414061..1414135,1414208..1414217,1414322..1414374)) IV 1 NT_166519.1 Function: nrd1 of S. pombe is involved in blocking the onset of sexual development by repressing the Ste11-regulated genes essential for conjugation and meiosis until cells reach a critical level of starvation.; Phenotype: deletion of nrd1 IN S. pombe causes cells to initiate sexual development without nutrient starvation.; Title: similarity to RNA binding protein nrd1p -Schizosaccharomyces pombe; uncharacterized protein 1414374 4979095 An02g06060 Aspergillus niger uncharacterized protein XP_059599983.1 1412818 R 5061 CDS An02g06070 4979096 complement(join(1416376..1418121,1418216..1418326)) IV 1 NT_166519.1 Function: crgA of M. circinelloides is involved in the regulation of carotenoid biosynthesis by light.; Similarity: the ORF shows similarity to RING finger proteins/transcription regulators from several species with diverse cellular function.; Title: strong similarity to carotenoid biosynthesis protein cgrA - Mucor circinelloide; See PMID 10651817; uncharacterized protein 1418326 4979096 An02g06070 Aspergillus niger uncharacterized protein XP_059599984.1 1416376 R 5061 CDS An02g06080 4979097 complement(join(1418843..1419044,1419114..1419280,1419338..1421179,1421228..1422958)) IV 1 NT_166519.1 Phenotype: S. pombe ste20 mutants are methylamine-sensitive, exhibit enhanced medium acidification and are defective in the utilization of glycerol as a carbon source.; Remark: ste20 of S. pombe is also called ste16 or SPBC12C2. 02c.; Similarity: the ORF shows strong similarity another developmental protein, to piaA of D. discoideum, a regulator protein involved in chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase.; Title: strong similarity to sexual differentiation and meiosis protein ste20p - Schizosaccharomyces pombe; See PMID 10467002; uncharacterized protein 1422958 4979097 An02g06080 Aspergillus niger uncharacterized protein XP_001399744.1 1418843 R 5061 CDS An02g06090 4979098 complement(join(1423888..1425143,1425203..1425251)) IV 1 NT_166519.1 Function: cellobiose dehydrogenase (CDH) is an enzyme produced under lignocellulose-degrading conditions by T. versicolor strain 52J (Tv) and several other wood-degrading fungi.; Similarity: the predicted ORF shows only weak similarity to the N-terminal part of cdh of T. versicolor,which is involved in heme binding; the C-terminal flavin domain is not homologues to the ORF.; Title: weak similarity to cellobiose dehydrogenase cdh - Trametes versicolor; uncharacterized protein 1425251 4979098 An02g06090 Aspergillus niger uncharacterized protein XP_001399745.1 1423888 R 5061 CDS An02g06100 84590351 join(1425896..1426081,1426137..1426347,1426452..1426548,1426636..1426754,1426823..1426911,1427024..1427293) IV 1 NT_166519.1 hypothetical protein 1427293 84590351 An02g06100 Aspergillus niger hypothetical protein XP_059599985.1 1425896 D 5061 CDS An02g06110 84590352 join(1427897..1428101,1428322..1428683) IV 1 NT_166519.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF; uncharacterized protein 1428683 84590352 An02g06110 Aspergillus niger uncharacterized protein XP_059599986.1 1427897 D 5061 CDS An02g06120 4979101 complement(join(1429604..1429762,1429935..1430066,1430196..1430795,1430918..1431066,1431155..1431266,1431334..1431394,1431651..1431661)) IV 1 NT_166519.1 Catalytic activity: tyr1 of S. cerevisiae converts prephenate + NADP(+) <=> 4-hydroxyphenylpyruvate + CO(2) + NADPH.; Remark: alternate names for tyr1 of S. cerevisiae are YBR1218 or YBR166c.; Title: strong similarity to prephenate dehydrogenase Tyr1 - Saccharomyces cerevisiae; uncharacterized protein 1431661 4979101 An02g06120 Aspergillus niger uncharacterized protein XP_059599987.1 1429604 R 5061 CDS An02g06130 4979102 join(1432386..1432452,1432526..1432598,1432761..1432921,1432982..1433133) IV 1 NT_166519.1 Remark: S14. e of N. crassa is also called crp-2.; Similarity: the ORF overlaps with A. niger ESTs an_3158, database entry EMBLEST:BE758901 and an_3216 EMBLEST:BE758954.; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S14.e - Neurospora crassa; cytoplasm; See PMID 1977135; 40S ribosomal protein uS11 1433133 4979102 An02g06130 Aspergillus niger 40S ribosomal protein uS11 XP_001399749.1 1432386 D 5061 CDS An02g06140 4979103 1433839..1435239 IV 1 NT_166519.1 Function: it is assumed that the B. napus subsp. napus Sll3 S-locus protein Cepp is involved in self-incompatibility.; Similarity: the predicted ORF shows weak similarity to S-locus protein 3 SP3 of B. rapa.; Title: similarity to hypothetical S-locus protein Cepp - Brassica napus; See PMID 10471721; See PMID 10559445; uncharacterized protein 1435239 4979103 An02g06140 Aspergillus niger uncharacterized protein XP_059599988.1 1433839 D 5061 CDS An02g06150 4979104 complement(join(1436529..1436714,1436785..1437389,1437479..1437893)) IV 1 NT_166519.1 Catalytic activity: bat2 of S. cerevisiae catalyses e. g. L-leucine + 2-oxoglutarate <=> 4-methyl-2-oxopentanoate + L-glutamate.; Phenotype: deletion of the gene for the cytosolic BAT2 of S. cerevisiae and the mitochondrial gene for bat1 resulted in an auxotrophy for branched-chain amino acids (Ile, Leu, and Val) and in a severe growth reduction on glucose-containing media, even after supply of these amino acids.; Remark: alternate names for bat2 of S. cerevisiae are J2209, YJR148w and TWT2.; Title: strong similarity to branched-chain amino acid aminotransferase Bat2 - Saccharomyces cerevisiae; See PMID 8798704; uncharacterized protein 1437893 4979104 An02g06150 Aspergillus niger uncharacterized protein XP_001399751.1 1436529 R 5061 CDS An02g06160 84590353 join(1439414..1439576,1439670..1439836,1439930..1440027,1440103..1440206,1440295..1440479) IV 1 NT_166519.1 hypothetical protein 1440479 84590353 An02g06160 Aspergillus niger hypothetical protein XP_059599989.1 1439414 D 5061 CDS An02g06170 84590354 complement(join(1440686..1440761,1440854..1440940,1441054..1441151,1441275..1441370)) IV 1 NT_166519.1 Remark: the ORF has an intron-exon structure, which is not typical for A. niger ORFs and is only 118 amino acids long.; Title: questionable ORF; uncharacterized protein 1441370 84590354 An02g06170 Aspergillus niger uncharacterized protein XP_059599990.1 1440686 R 5061 CDS An02g06180 4979107 join(1442152..1442292,1442491..1443081,1443131..1443282,1443358..1443537,1443591..1443945) IV 1 NT_166519.1 Function: nit-4 of N. crassa is a pathway-specific regulatory transcription activator, which is required for the expression of the structural genes for nitrate and nitrite reductase.; Similarity: The predicted ORF is 423 amino aids shorter at its C-terminus than nit-4 of N. crassa.; Similarity: the ORF shows similarity to some zinc finger transcription activators with various cellular function.; Title: strong similarity to nitrogen assimilation regulatory protein nit-4 - Neurospora crassa; nucleus; See PMID 1388109; See PMID 1531376; See PMID 1840634; uncharacterized protein 1443945 4979107 An02g06180 Aspergillus niger uncharacterized protein XP_001399754.3 1442152 D 5061 CDS An02g06185 84590355 complement(join(1444227..1444290,1444367..1444446)) IV 1 NT_166519.1 hypothetical protein 1444446 84590355 An02g06185 Aspergillus niger hypothetical protein XP_059599991.1 1444227 R 5061 CDS An02g06190 84590356 complement(join(1444641..1444968,1445074..1445166,1445261..1445415)) IV 1 NT_166519.1 hypothetical protein 1445415 84590356 An02g06190 Aspergillus niger hypothetical protein XP_059599992.1 1444641 R 5061 CDS An02g06200 84590357 complement(join(1445877..1446061,1446181..1446278,1446332..1446446,1446540..1446639)) IV 1 NT_166519.1 hypothetical protein 1446639 84590357 An02g06200 Aspergillus niger hypothetical protein XP_059599993.1 1445877 R 5061 CDS An02g06210 84590358 complement(join(1447453..1447713,1447818..1447855,1447903..1448194,1448248..1448256)) IV 1 NT_166519.1 hypothetical protein 1448256 84590358 An02g06210 Aspergillus niger hypothetical protein XP_059599994.1 1447453 R 5061 CDS An02g06220 4979112 join(1448281..1449232,1449293..1451190) IV 1 NT_166519.1 Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to hypothetical protein CAF06122.1 - Neurospora crassa; uncharacterized protein 1451190 4979112 An02g06220 Aspergillus niger uncharacterized protein XP_001399759.1 1448281 D 5061 CDS An02g06230 4979113 complement(1452332..1453387) IV 1 NT_166519.1 Complex: TFIIB binds directly to TBP, recruits RNA polymerase II, in part through an interaction with the small subunit of TFIIF.; Function: TFIIB is required for association of RNA polymerase II to the mRNA transcription initiation complex.; Function: TFIIB stabilizes TBP binding to the TATA element.; Remark: a splice site upstream of the START codon was detected.; Similarity: the predicted ORF shows strong similarity to TFIIB of several species.; Title: strong similarity to transcription initiation factor TFIIB - Kluyveromyces lactis; nucleus; See PMID 9519295; See PMID 8346020; uncharacterized protein 1453387 4979113 An02g06230 Aspergillus niger uncharacterized protein XP_001399760.1 1452332 R 5061 CDS An02g06240 4979114 join(1453945..1453967,1454168..1454330,1454404..1454482,1454594..1454862) IV 1 NT_166519.1 Catalytic activity: ATP14 of S. cerevisiae catalyses the reaction ATP + H2O <=> ADP + phosphate.; Function: ATP14 of S. cerevisiae couples H+ transport via the inner mitochondrial membrane to ATP synthesis.; Phenotype: the ATP14 mutant of S. cerevisiae shows a high percentage of rho-cells arising spontaneously and no detectable oligomycin-sensitive ATPase activity.; Remark: ATP14 of S. cerevisiae is also called YLR295C or L8003. 20.; Similarity: the predicted ORF shows local identity with some A. niger ESTs, e. g. EMBLEST:BE760081.; Title: similarity to ATP synthase subunit h Atp14 -Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8702761; See PMID 11083870; uncharacterized protein 1454862 4979114 An02g06240 Aspergillus niger uncharacterized protein XP_001399761.3 1453945 D 5061 CDS An02g06250 84590359 join(1454930..1454945,1455017..1455117,1455229..1455482,1455577..1455625) IV 1 NT_166519.1 hypothetical protein 1455625 84590359 An02g06250 Aspergillus niger hypothetical protein XP_059599995.1 1454930 D 5061 CDS An02g06260 84590360 join(1456161..1456167,1456500..1456765) IV 1 NT_166519.1 hypothetical protein 1456765 84590360 An02g06260 Aspergillus niger hypothetical protein XP_059599996.1 1456161 D 5061 CDS An02g06270 84590361 join(1457276..1457338,1457517..1457579,1457673..1457770,1457832..1458055,1458308..1458714) IV 1 NT_166519.1 hypothetical protein 1458714 84590361 An02g06270 Aspergillus niger hypothetical protein XP_059599997.1 1457276 D 5061 CDS An02g06280 4979118 join(1458738..1459585,1459644..1462173) IV 1 NT_166519.1 Similarity: the predicted ORF shows local weak similarity to chitinase A of A. nidulans in the N-terminal region.; Similarity: the similarity of the predicted ORF to SPAC7D4. 03c of S. pombe is particularly strong in the central part of the molecule.; Title: strong similarity to hypothetical protein SPAC7D4.03c - Schizosaccharomyces pombe; uncharacterized protein 1462173 4979118 An02g06280 Aspergillus niger uncharacterized protein XP_001399765.1 1458738 D 5061 CDS An02g06290 84590362 join(1462751..1462759,1462884..1462903,1463113..1463135,1463219..1463268) IV 1 NT_166519.1 Title: questionable ORF; uncharacterized protein 1463268 84590362 An02g06290 Aspergillus niger uncharacterized protein XP_059599998.1 1462751 D 5061 CDS An02g06300 4979120 complement(join(1463834..1464022,1464077..1466554)) IV 1 NT_166519.1 Function: in human hydrolysis of the neuropeptide N-acetyl-L-aspartyl-L-glutamate (NAAG) by N-acetylated alpha-linked acidic dipeptidase (NAALADase) to release glutamate may be important in a number of neurodegenerative disorders in which excitotoxic mechanisms are implicated.; Similarity: the predicted A. niger protein shows similarity to several putative and known carboxypeptidase proteins.; Similarity: the predicted A. niger proteins is about 150-200 aminoacids longer at the N-terminus in comparison to similar proteins.; Title: similarity to naaladase II - Homo sapiens; See PMID 10085079; uncharacterized protein 1466554 4979120 An02g06300 Aspergillus niger uncharacterized protein XP_001399767.1 1463834 R 5061 CDS An02g06310 84590363 complement(join(1466624..1466825,1466911..1467049,1467145..1467210,1467483..1467537,1467646..1467719,1467827..1467862,1467935..1468103,1468417..1468560,1468643..1468804)) IV 1 NT_166519.1 Title: questionable ORF; uncharacterized protein 1468804 84590363 An02g06310 Aspergillus niger uncharacterized protein XP_059606850.1 1466624 R 5061 CDS An02g06320 4979122 join(1469944..1470003,1470084..1470186,1470264..1471345,1471409..1471546) IV 1 NT_166519.1 Catalytic activity: hydroxymethylglutaryl-CoA synthases convert (S)-3-hydroxy-3-methylglutaryl-CoA + CoA to acetyl-CoA + H2O + acetoacetyl-CoA.; Function: hmgs of S. cerevisiae condenses acetyl-CoA with acetoacetyl-CoA to form hmg-CoA, which is the substrate for hmg-CoA reductase.; Remark: alternative names for S. cerevisiae HMGS are YM4987. 09c and YML126c.; Title: strong similarity to 3-hydroxy-3-methylglutaryl-CoA synthase Erg13 -Saccharomyces cerevisiae; See PMID 2880580; uncharacterized protein 1471546 4979122 An02g06320 Aspergillus niger uncharacterized protein XP_001399769.1 1469944 D 5061 CDS An02g06330 4979123 1473355..1475307 IV 1 NT_166519.1 Title: similarity to hypothetical protein B2I10.080 - Neurospora crassa; uncharacterized protein 1475307 4979123 An02g06330 Aspergillus niger uncharacterized protein XP_001399770.1 1473355 D 5061 CDS An02g06340 4979124 join(1475804..1476143,1476219..1476435,1476500..1476990,1477065..1477671,1477732..1477742,1477878..1477939,1477972..1478319) IV 1 NT_166519.1 Title: similarity to hypothetical protein BAB76423.1 - Nostoc sp.; uncharacterized protein 1478319 4979124 An02g06340 Aspergillus niger uncharacterized protein XP_059606851.1 1475804 D 5061 CDS An02g06350 4979125 join(1479040..1479174,1479364..1479603,1479667..1480521,1480587..1481017,1481072..1481214,1481268..>1483463) IV 1 NT_166519.1 Function: pmc1 of S. cerevisiae pumps Ca2+ into the vacuole and participates in the control of the cytosolic free calcium together with atc1 protein.; Phenotype: mutations in calcineurin A or B subunits or the inhibitory compounds FK506 and cyclosporin A restore growth of pmc1 mutants in high Ca2+ media.; Remark: a putative sequencing error results in an frameshift.; Remark: alternate names for pmc1 of S. cerevisiae are G3749 or YGL006w.; Remark: the predicted ORF shows similarity with the A. nidulans EST AA784502.; Repression: the growth of S. cerevisae pmc1 mutants is inhibited by added Ca2+ only after activation of calcineurin.; Title: strong similarity to calcium-transporting ATPase Pmc1 - Saccharomyces cerevisiae [putative frameshift]; vacuole; putative frameshift; See PMID 7507493; uncharacterized protein 1483463 4979125 An02g06350 Aspergillus niger uncharacterized protein XP_059606852.1 1479040 D 5061 CDS An02g06360 4979126 join(1484166..1484524,1484611..1484827) IV 1 NT_166519.1 Complex: arc16 of H. sapiens belongs to a complex composed of arp2, arp3, p41-arc, p34-arc, p21-arc, p20-arc and p16-arc.; Function: arc16 of H. sapiens is part of a complex implicated in the control of actin polymerisation in cells.; Remark: a splice site was detected upstream of the START codon; Remark: synomys for arc16 of H. sapiens are p16-arc or arpC5 family protein.; Title: similarity to arp2/3 complex 16kD subunit arc16 - Homo sapiens; cytoskeleton; See PMID 9230079; uncharacterized protein 1484827 4979126 An02g06360 Aspergillus niger uncharacterized protein XP_001399773.1 1484166 D 5061 CDS An02g06370 4979127 complement(join(1485011..1485847,1485915..1486175)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein B12F1.50 - Neurospora crassa; uncharacterized protein 1486175 4979127 An02g06370 Aspergillus niger uncharacterized protein XP_001399774.1 1485011 R 5061 CDS An02g06380 4979128 join(1486572..1486625,1486662..1486915,1486982..1488318,1488465..1488653,1488747..1488818,1488973..>1489167) IV 1 NT_166519.1 Function: N. crassa ro-2 mutations disrupted nuclear and vacuole distribution.; Remark: N. crassa ro-2 has independently been cloned twice with different N- and C-terminal sequences.; Remark: information concerning N. crassa ro-2 has only partially been published and additional information is avialable via http://www. fgsc. net/asil2000/invitedabs. htm.; Similarity: N. crassa ro-2 has independently been classified as p62 subunit of Arp1.; Similarity: N. crassa ro-2 originally has been classified as a novel 80 kDa protein that has two Cys-rich motifs which resemble zinc-binding LIM or RING domains thought to mediate protein-protein interactions as well as several potential binding sites for Src homology 3 (SH3) domains.; Title: strong similarity to RO2 - Neurospora crassa [putative frameshift]; putative frameshift; See PMID 9159520; uncharacterized protein 1489167 4979128 An02g06380 Aspergillus niger uncharacterized protein XP_059606853.1 1486572 D 5061 CDS An02g06390 4979129 complement(join(1489747..1490110,1490269..1490351,1490703..1490858)) IV 1 NT_166519.1 Remark: RP30 is also called RPS7A or RPS30 or YOR096W or YOR3177W.; Remark: there are two genes for the ribosomal protein S7 in yeast.; Similarity: the predicted ORF is identical to the EMBLEST BE759339 of A. niger.; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit Rp30 - Saccharomyces cerevisiae; cytoplasm; See PMID 1737755; 40S ribosomal protein eS7 1490858 4979129 An02g06390 Aspergillus niger 40S ribosomal protein eS7 XP_001399776.1 1489747 R 5061 CDS An02g06400 4979130 complement(join(1491540..1492180,1492332..1492395,1492500..1492583)) IV 1 NT_166519.1 Function: S. cerevisiae VPS21 encodes a rab5 like small GTPase that is involved in both the vacuolar protein sorting and the endocytic trafficking and mediates fusion of transport vesicles with the endosomal/prevacuolar compartment.; Remark: VPS21 of S. cerevisiae is also called YPT51 or O3154 or YOR089c or YOR3154c.; Remark: a splice site was detected upstream of the START codon.; Similarity: the predicted ORF partially overlaps with the A. nidulans EMBLEST AA788364.; Title: strong similarity to small Ras-like GTPase Vps21 - Saccharomyces cerevisiae; endosome; See PMID 8586662; uncharacterized protein 1492583 4979130 An02g06400 Aspergillus niger uncharacterized protein XP_001399777.1 1491540 R 5061 CDS An02g06410 84590364 join(1493030..1493122,1493138..1493237,1493304..1493459,1493729..1493989,1495271..1495357,1495712..1495806,1496996..1497077,1497103..1497269,1497903..1497967,1498569..1498800,1501503..1501618,1501732..1501772,1502243..1502315,1503087..1503172,1503603..1503721) IV 1 NT_166519.1 Remark: multiple short Exons of the genemodel suggest a questionable ORF, but the N-terminal region shows some similarity to type II secretion system protein gspE1 of Halobacterium sp.; Title: questionable ORF; uncharacterized protein 1503721 84590364 An02g06410 Aspergillus niger uncharacterized protein XP_059606854.1 1493030 D 5061 CDS An02g06420 4979132 complement(join(1505596..1506054,1506107..1506179,1506233..1506295,1506354..1507048)) IV 1 NT_166519.1 Catalytic activity: acetate kinases convert ATP + acetate to ADP + acetyl phosphate.; Function: acetate kinases facilitate the production of acetyl-CoA by phosphorylating acetate in the presence of ATP and a divalent cation.; Phenotype: the growth of a bacterial mutant lacking acetate kinase has been shown to be inhibited by glucose,suggesting that the enzyme is also involved in excretion of excess carbohydrate.; Title: strong similarity to acetate kinase ackA -Escherichia coli; cytoplasm; See PMID 7883769; See PMID 8226682; uncharacterized protein 1507048 4979132 An02g06420 Aspergillus niger uncharacterized protein XP_001399779.3 1505596 R 5061 CDS An02g06430 4979133 join(1507504..1507666,1507720..1507794,1507855..1508089,1508139..1508291,1508342..1508651,1508701..1509321,1509382..1510207,1510266..1510303) IV 1 NT_166519.1 Catalytic activity: transketolase catalyzes the reversible transfer of a two-carbon ketol unit to an aldose receptor, e. g. Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-ribose 5-phosphate + D-xylulose 5-phosphate.; Remark: the transketolase TKL1 of S. cerevisiae is also called YPR074C or YP9499. 29C.; Similarity: the predicted ORF shows strong similarity to the hypothetical transketolase SPBC24C6. 09c of S. pombe.; Title: similarity to transketolase Tkt1 -Saccharomyces cerevisiae; cytoplasm; See PMID 8226984; See PMID 9924800; uncharacterized protein 1510303 4979133 An02g06430 Aspergillus niger uncharacterized protein XP_001399780.1 1507504 D 5061 CDS An02g06440 4979134 join(1511881..1512103,1512163..1512255,1512317..1512915) IV 1 NT_166519.1 Function: rtm1 of S. cerevisiae confers resistance to the toxicity of molasse and might thus be a transporter involved in detoxification.; Title: strong similarity to molasses resistency protein Rtm1 - Saccharomyces cerevisiae; plasma membrane; See PMID 7672593; uncharacterized protein 1512915 4979134 An02g06440 Aspergillus niger uncharacterized protein XP_001399781.1 1511881 D 5061 CDS An02g06450 4979135 complement(join(1513898..1514649,1514716..1515019)) IV 1 NT_166519.1 Similarity: shows some similarity to several NADH dehydrogenase subunits.; hypothetical protein 1515019 4979135 An02g06450 Aspergillus niger hypothetical protein XP_001399782.1 1513898 R 5061 CDS An02g06460 4979136 complement(join(1515477..1515920,1515978..1516318,1516371..1516612,1516675..1517040,1517100..1517401)) IV 1 NT_166519.1 Similarity: aminoacids 240 to 450 show some similarity to proteins of M. jannaschii and P. horikoshii.; Title: weak similarity to hypothetical protein MJ0147 - Methanococcus jannaschii; uncharacterized protein 1517401 4979136 An02g06460 Aspergillus niger uncharacterized protein XP_001399783.1 1515477 R 5061 CDS An02g06470 4979137 join(1519087..1519632,1519755..1520846,1520981..1521133,1521248..1521322,1521422..1521457) IV 1 NT_166519.1 Function: het-6 of N. crassa is involved in the restriction of heterokaryon formation during asexual growth.; Remark: in filamentous fungi, vegetative cell fusion between genotypically distinct individuals leads to a cell-death reaction known as vegetative or heterokaryon incompatibility.; Similarity: het-6(OR) of N. crassa has three regions of amino acid sequence similarity to the predicted product of the het-e vegetative incompatibility gene in P. anserina and to the predicted product of tol, which mediates mating-type vegetative incompatibility in N. crassa.; Title: similarity to heterokaryon incompatibility protein het-6 - Neurospora crassa; See PMID 10880472; See PMID 11035941; See PMID 11092825; uncharacterized protein 1521457 4979137 An02g06470 Aspergillus niger uncharacterized protein XP_059606855.1 1519087 D 5061 CDS An02g06490 84590365 join(1523117..1523125,1523178..1523335,1523421..1523539,1523595..1523848) IV 1 NT_166519.1 hypothetical protein 1523848 84590365 An02g06490 Aspergillus niger hypothetical protein XP_059606856.1 1523117 D 5061 CDS An02g06500 4979141 complement(join(1524750..1524875,1524963..1525223,1525279..1525411,1525483..1525589,1525647..1525924,1525971..1526037,1526091..1526135,1526210..1526751,1526825..1526876)) IV 1 NT_166519.1 Remark: dnaK proteins belong to the heat shock protein 70 family.; Similarity: the similarity of the predicted ORF to heat shock proteins of different spezies is restricted to the N-terminal region.; Title: similarity to dnaK-type molecular chaperone dnaK - Buchnera sp.; uncharacterized protein 1526876 4979141 An02g06500 Aspergillus niger uncharacterized protein XP_059606857.1 1524750 R 5061 CDS An02g06510 84590366 join(1527239..1527241,1527390..1527942,1528027..1528673) IV 1 NT_166519.1 Similarity: shows similarity to central region of putative lipid transfer proteins of P. sativum and A. thaliana.; Title: weak similarity to hypothetical precursor of chloroplastic lipid transfer protein M30 - Pisum sativum; uncharacterized protein 1528673 84590366 An02g06510 Aspergillus niger uncharacterized protein XP_059606858.1 1527239 D 5061 CDS An02g06520 4979143 complement(join(1529660..1529962,1530053..1530070,1530130..1530320,1530390..1530664,1530723..1530894,1530946..1531278,1531334..1531370)) IV 1 NT_166519.1 Catalytic activity: Na+ (in) + 2H+ (out) Na+ (out) + 2H+ (in).; Function: the Na+/H+ antiporter NapA of E. hirae can mediate sodium uptake when a transmembrane pH gradient is present.; Similarity: the predicted ORF shows similarity to Na+/H+ antiporters of several bacteria.; Title: strong similarity to Na+/H+ antiporter NapA -Enterococcus hirae; See PMID 9278382; uncharacterized protein 1531370 4979143 An02g06520 Aspergillus niger uncharacterized protein XP_059606859.1 1529660 R 5061 CDS An02g06530 4979144 join(1532297..1532333,1532411..1532476,1532544..1532599,1532671..1536261) IV 1 NT_166519.1 Function: cluA of D. discoideum is supposed to act as a linker between motor molecules and mitochondria.; Phenotype: disruption of cluA in D. discoideum results in clustering of mitochondria near the cell center,in addition the mutants show a cytokinesis defect.; Similarity: the predicted ORF includes the EST BE758770 of A. niger.; Similarity: the predicted ORF shows strong similarity to proteins annotated as predicted EIF3 proteins of different spezies, this might be a database annotation error.; Title: strong similarity to protein required for dispersion of mitochondria cluA - Dictyostelium discoideum; See PMID 9150866; uncharacterized protein 1536261 4979144 An02g06530 Aspergillus niger uncharacterized protein XP_001399789.1 1532297 D 5061 CDS An02g06540 84590367 complement(join(1536954..1537113,1537251..1537327,1537386..1537704,1537761..1537823,1537897..1538028,1538092..1538195)) IV 1 NT_166519.1 hypothetical protein 1538195 84590367 An02g06540 Aspergillus niger hypothetical protein XP_059606860.1 1536954 R 5061 CDS An02g06550 4979146 join(1540844..1541507,1541565..1541671,1541824..1541862,1541919..>1542689) IV 1 NT_166519.1 Catalytic activity: NADH + 2 Fe(3+) <=> NAD(+) + 2 Fe(2+).; Function: Fre1p of S. cerevisiae is required for the activity of the principal iron uptake system which utilizes a reductase activity that acts on ferric iron chelates external to the cell.; Remark: the ferric reductase FRE1 of S. cerevisiae is also called L8167. 2 or YLR214w.; Repression: mRNA levels of FRE1 from S. cerevisiae are repressed by iron.; Similarity: Fre1p of S. cerevisiae is about 100 amino acids longer at the N- and C-terminus.; Similarity: the predicted ORF shares similarities with several other putative ferric reductases, e. g. the gene product of cfl1 from C. albicans.; Title: similarity to ferric reductase Fre1 -Saccharomyces cerevisiae; plasma membrane; See PMID 1570306; uncharacterized protein 1542689 4979146 An02g06550 Aspergillus niger uncharacterized protein XP_059606861.1 1540844 D 5061 CDS An02g06560 4979147 join(1543823..1543902,1543961..1544014,1544072..1544690) IV 1 NT_166519.1 Catalytic activity: RX + glutathione = HX + R-S-glutathione.; Pathway: glutathione metabolism.; Remark: the isoJ gene from Rhodococcus sp. was overexpressed in Escherichia coli and was found to have activity with 1-chloro-2,4-dinitrobenzene and 3,4-dichloro-1-nitrobenzene but not with 1,2-epoxy-2-methyl-3-butene.; Similarity: belongs to the glutathione transferase family.; Title: strong similarity to glutathione S-transferase isoJ - Rhodococcus sp.; See PMID 10715003; uncharacterized protein 1544690 4979147 An02g06560 Aspergillus niger uncharacterized protein XP_001399792.3 1543823 D 5061 CDS An02g06570 4979148 join(1545021..1545186,1545246..1545459,1545519..1545736,1545988..1546211,1546266..1546374,1546424..1546629,1546686..1547207,1547259..1547300) IV 1 NT_166519.1 Remark: functional assays establish the ZFM1 protein as a transcriptional repressor. ZFM1 protein represses Gal4-GQC-mediated transcription, and this activity requires both a repression domain found in the N-terminal 137 amino acids of the protein, as well as a GQC interaction region.; Title: strong similarity to transcription factor ZFM1 - Homo sapiens; See PMID 9506990; uncharacterized protein 1547300 4979148 An02g06570 Aspergillus niger uncharacterized protein XP_001399793.1 1545021 D 5061 CDS An02g06580 4979149 join(1548061..1548446,1548545..1548693,1548763..1548850,1548905..1549401,1549451..1550346) IV 1 NT_166519.1 Remark: AE2 anion exchangers from chicken are involved in the regulation of intracellular pH in each of these gastric epithelial cell types. In situ hybridization analyses have further revealed that AE2 transcripts accumulate to very high levels within the acid-secreting epithelial cells of the profound gland in the stomach and,to a lesser extent, within the mucus-secreting cells of the superficial gland that line the stomach lumen.; Similarity: belongs to the anion exchanger family.; Title: strong similarity to anion exchanger AE2-1 -Gallus gallus; See PMID 8621532; See PMID 11193604; uncharacterized protein 1550346 4979149 An02g06580 Aspergillus niger uncharacterized protein XP_001399794.1 1548061 D 5061 CDS An02g06590 4979150 join(1552265..1552381,1552813..1553187,1553237..1553349,1553401..1553603,1553655..1553803,1553860..1555696,1555758..1555954) IV 1 NT_166519.1 Remark: GERp95 belongs to a family of highly conserved proteins in metazoans and Schizosaccharomyces pombe. It has recently been determined that plant and Drosophila homologues of GERp95 are important for controlling the differentiation of stem cells (Bohmert et al., 1998; Cox et al., 1998; Moussian et al., 1998).; Remark: GERp95 is a cytoplasmically exposed peripheral membrane protein that exists in a protease-resistant complex.; Remark: these proteins may exert their effects on cell differentiation from the level of intracellular membranes.; Title: strong similarity to Golgi ER protein 95 kDa GERp95 - Rattus norvegicus; See PMID 10512872; uncharacterized protein 1555954 4979150 An02g06590 Aspergillus niger uncharacterized protein XP_001399795.3 1552265 D 5061 CDS An02g06600 4979151 complement(join(1558018..1558642,1558699..1559384,1559434..1560572,1560635..1561712)) IV 1 NT_166519.1 Remark: SPT7 from yeast is a histone acetyltransferase SAGA complex member transcription factor.; Remark: SPT7 plays an important role in transcription initiation in vivo.; Similarity: belongs to the unassigned bromodomain proteins.; Title: strong similarity to transcription factor Spt7 - Saccharomyces cerevisiae; See PMID 7713415; See PMID 1350857; uncharacterized protein 1561712 4979151 An02g06600 Aspergillus niger uncharacterized protein XP_001399796.1 1558018 R 5061 CDS An02g06610 4979152 join(1562215..1562320,1562675..1563282) IV 1 NT_166519.1 Title: similarity to hypothetical protein SPAC11E3.10 - Schizosaccharomyces pombe; uncharacterized protein 1563282 4979152 An02g06610 Aspergillus niger uncharacterized protein XP_059606862.1 1562215 D 5061 CDS An02g06620 84590368 join(1563997..1564124,1564241..1564292) IV 1 NT_166519.1 hypothetical protein 1564292 84590368 An02g06620 Aspergillus niger hypothetical protein XP_059606863.1 1563997 D 5061 CDS An02g06630 4979154 complement(join(1564422..1565267,1565326..1565591,1565725..1566152,1566200..1566310,1567055..1567071)) IV 1 NT_166519.1 Catalytic activity: protein tyrosine phosphate + H2O = protein tyrosine + orthophosphate.; Remark: pyp2+ act as negative regulators of mitosis upstream of the wee1+/mik1+ pathway.; Remark: the pyp2 in fission yeast is about 150 amino acids longer, but the variability in length is great over different organisms.; Similarity: belongs to the tyrosine specific protein phosphatase and dual specificity protein phosphatase family.; Title: strong similarity to protein-tyrosine-phosphatase yp2p - Schizosaccharomyces pombe; See PMID 1448087; See PMID 1464319; uncharacterized protein 1567071 4979154 An02g06630 Aspergillus niger uncharacterized protein XP_059606864.1 1564422 R 5061 CDS An02g06640 84590369 complement(join(1567104..1567199,1567318..1567486,1567577..1567785,1567867..1567926,1568019..1568087)) IV 1 NT_166519.1 hypothetical protein 1568087 84590369 An02g06640 Aspergillus niger hypothetical protein XP_059606865.1 1567104 R 5061 CDS An02g06650 84590370 join(1568309..1568460,1568799..1568858,1568939..1569013,1569242..1569274,1569391..1569514,1570004..1570057) IV 1 NT_166519.1 hypothetical protein 1570057 84590370 An02g06650 Aspergillus niger hypothetical protein XP_059606866.1 1568309 D 5061 CDS An02g06660 4979157 1570768..1571589 IV 1 NT_166519.1 Remark: putative serin threonin rich protein.; hypothetical protein 1571589 4979157 An02g06660 Aspergillus niger hypothetical protein XP_001399802.1 1570768 D 5061 CDS An02g06670 4979158 join(1572940..1573531,1573598..1573872) IV 1 NT_166519.1 Remark: only a small domain matches with homologe proteins.; Title: weak similarity to regulator protein Snf5 -Saccharomyces cerevisiae; uncharacterized protein 1573872 4979158 An02g06670 Aspergillus niger uncharacterized protein XP_001399803.1 1572940 D 5061 CDS An02g06680 4979159 complement(join(1574390..1574506,1574580..1575433,1575513..>1575636)) IV 1 NT_166519.1 Remark: Pex19p in Pichia pastoris functions at an early stage of peroxisome biogenesis.; Remark: import of peroxisomal targeting signal 1-and 2-containing peroxisomal matrix proteins is defective in pex19 mutants.; Similarity: to pex19 proteins in different organisms such as S. cerevisiae, Homo sapines. .; Title: strong similarity to protein Pex19 - Pichia pastoris [truncated ORF]; See PMID 10051604; See PMID 10359594; uncharacterized protein 1575636 4979159 An02g06680 Aspergillus niger uncharacterized protein XP_001399804.1 1574390 R 5061 CDS An02g06700 4979160 join(1579738..1579917,1580392..1580608,1580720..1581220,1581300..1581604) IV 1 NT_166519.1 Remark: mutations within the meaB gene elicit the inappropriate expression of several activities subject to nitrogen metabolite repression in Aspergillus nidulans and also have some unrelated phenotypic effects.; Title: strong similarity to nitrogen metabolite repression protein mEAB - Aspergillus nidulans; See PMID 8690087; See PMID 9352912; uncharacterized protein 1581604 4979160 An02g06700 Aspergillus niger uncharacterized protein XP_001399805.3 1579738 D 5061 CDS An02g06710 4979161 join(1582940..1582960,1583271..1583289,1583490..1583660,1583733..1583874,1583965..1584523) IV 1 NT_166519.1 Remark: STM1 gene has been identified as a multicopy suppressor of mutations in several genes involved in mitosis (e. g. TOM1, MPT5, and POP2).; Title: strong similarity to suppressor of tom1 protein Mpt4 - Saccharomyces cerevisiae; See PMID 7548221; See PMID 10681538; uncharacterized protein 1584523 4979161 An02g06710 Aspergillus niger uncharacterized protein XP_001399806.1 1582940 D 5061 CDS An02g06720 4979162 complement(join(1585450..1585479,1585636..1585780,1585910..1586604,1586655..1586785,1586837..1587842,1587897..1588302,1588356..1588615)) IV 1 NT_166519.1 Catalytic activity: L-glutamine + H2O = L-glutamate + NH3.; Pathway: glutamate metabolism; D-glutamine and D-glutamate metabolism; nitrogen metabolism.; Remark: also strong similarity to A. oryzae glutaminase protein patent WO9960104-A1.; Remark: purified glutaminase from A. oryzae catalysed the hydrolysis not only of L-glutamine but also of D-glutamine.; Remark: the glutaminase from Neurospora crassa is approximately the same lenght as the predicted orf, whereas the homolog protein from A. oryzae is 200 amino acids shorter.; Remark: the purified glutaminase and determined partial amino-acid sequence can be used for enhancing taste particularly in glutamic acid-converting food processing to give e. g. seasoning sauces and pastes as well as other seasoning materials.; Title: strong similarity to glutaminase A gtaA -Aspergillus oryzae; See PMID 10952006; uncharacterized protein 1588615 4979162 An02g06720 Aspergillus niger uncharacterized protein XP_001399807.3 1585450 R 5061 CDS An02g06730 84590371 complement(join(1590498..1590588,1590933..1591339)) IV 1 NT_166519.1 hypothetical protein 1591339 84590371 An02g06730 Aspergillus niger hypothetical protein XP_059603400.1 1590498 R 5061 CDS An02g06740 4979164 join(1591500..1591808,1591890..1592039,1592094..1592732) IV 1 NT_166519.1 hypothetical protein 1592732 4979164 An02g06740 Aspergillus niger hypothetical protein XP_059603401.1 1591500 D 5061 CDS An02g06750 4979165 complement(join(1593129..1594188,1594249..1594757)) IV 1 NT_166519.1 Remark: also strong similarity to DEADbox family protein 3 Homo sapiens patent WO9825145-A1.; Remark: proteins of the DEAD family of putative ATP-dependent RNA helicases have been implicated in translation initiation, ribosome assembly, and RNA processing in a variety of organisms from E. coli to man.; Similarity: belongs to the 'dead' box family helicase.; Title: strong similarity to DEAD box protein Dbp45A - Drosophila melanogaster; See PMID 7692973; uncharacterized protein 1594757 4979165 An02g06750 Aspergillus niger uncharacterized protein XP_001399810.1 1593129 R 5061 CDS An02g06760 4979166 complement(join(1594852..1594911,1594988..1595304,1595393..1596094,1596149..1597151,1597214..1597645,1597702..1598610)) IV 1 NT_166519.1 Remark: RNA14 and RNA15 in yeast correlate with a reduction of mRNA stability and poly(A) tail length.; Remark: the yeast RNA14 is a component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing. interacts with fip1 and probably also with RNA15.; Title: similarity to mRNA 3-end processing protein Rna14 - Saccharomyces cerevisiae; See PMID 1674817; uncharacterized protein 1598610 4979166 An02g06760 Aspergillus niger uncharacterized protein XP_001399811.3 1594852 R 5061 CDS An02g06770 4979167 join(1599346..1599454,1599507..1599546,1599607..1599915,1599971..1600376) IV 1 NT_166519.1 Remark: also strong similarity to wheat anti-silencing protein ASP from Triticum aestivum patent WO9955870-A2.; Remark: the phenotype suggested a role for ASF1 in DNA repair and chromosome maintenance.; Remark: yeast ASF1 overexpression weakens repression of genes near telomeres.; Title: strong similarity to anti-silencing function protein Asf1 - Saccharomyces cerevisiae; See PMID 9290207; See PMID 10759893; uncharacterized protein 1600376 4979167 An02g06770 Aspergillus niger uncharacterized protein XP_001399812.1 1599346 D 5061 CDS An02g06780 4979168 complement(join(1601740..1601765,1601818..1602099,1602152..1602273,1602328..1602883,1602931..1604502,1604561..1604900,1604990..1605076)) IV 1 NT_166519.1 Remark: Sro7 function was believed to be the targeting of the myosin proteins to their intrinsic pathways, but nowadays more likely is its role in protein exocytosis, as it is implicated in docking and fusion of post-Golgi vesicles with the plasma membrane.; Remark: yeast SRO7 was identified as a multicopy suppressor of a defect in Rho3p, a small GTPase that maintains cell polarity.; Similarity: belongs to the lethal(2)giant protein family.; Title: strong similarity to suppressor of rho3 Sro7 - Saccharomyces cerevisiae; See PMID 9691031; See PMID 10402465; uncharacterized protein 1605076 4979168 An02g06780 Aspergillus niger uncharacterized protein XP_001399813.1 1601740 R 5061 CDS An02g06790 4979169 complement(join(1605666..1605807,1605926..1606018,1606085..1606545)) IV 1 NT_166519.1 Title: weak similarity to hypothetical protein CAD60729.1 - Podospora anserina; uncharacterized protein 1606545 4979169 An02g06790 Aspergillus niger uncharacterized protein XP_001399814.3 1605666 R 5061 CDS An02g06800 84590372 join(1607008..1607037,1607078..1607143,1607225..1607500) IV 1 NT_166519.1 hypothetical protein 1607500 84590372 An02g06800 Aspergillus niger hypothetical protein XP_059603402.1 1607008 D 5061 CDS An02g06810 4979171 complement(join(1608142..1608258,1608332..1608472,1608537..1608751,1608817..1608982,1609090..1609224,1609322..1609363)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein YGL232w - Saccharomyces cerevisiae; uncharacterized protein 1609363 4979171 An02g06810 Aspergillus niger uncharacterized protein XP_001399816.3 1608142 R 5061 CDS An02g06820 4979172 join(1610241..1610430,1610513..1611740,1611798..1612005,1612084..>1612157) IV 1 NT_166519.1 Catalytic activity: a 2-oxo acid = an aldehyde + CO2; pyruvate = acetaldehyde + CO2.; Pathway: glycolysis / gluconeogenesis.; Remark: PDC levels are a major determinant of ethanol production.; Similarity: belongs to the thiamine-diphosphate protein family.; Title: strong similarity to pyruvate decarboxylase pdcA - Aspergillus oryzae; putative sequencing error; See PMID 9210590; uncharacterized protein 1612157 4979172 An02g06820 Aspergillus niger uncharacterized protein XP_059603403.1 1610241 D 5061 CDS An02g06830 4979173 join(1613776..1618505,1618558..1618675) IV 1 NT_166519.1 Catalytic activity: ATP + a protein = ADP + a phosphoprotein.; Remark: the cellular integrity and response to hypoosmotic conditions in the yeast S. cerevisiae are ensured by a MAP kinase signal transduction pathway mediated by the yeast homolog of mammalian protein kinase C. Bck1p functions as the MAP kinase kinase kinase of this pathway.; Similarity: belongs to unassigned Ser/Thr or Tyr-specific protein kinases; shows protein kinase homology.; Title: similarity to MAP kinase kinase kinase KLBCK1 - Candida sphaerica; deleted EC_number 2.7.1.37; See PMID 10329146; uncharacterized protein 1618675 4979173 An02g06830 Aspergillus niger uncharacterized protein XP_001399818.1 1613776 D 5061 CDS An02g06840 4979174 complement(join(1619060..1621000,1621035..1621374,1621438..1621646)) IV 1 NT_166519.1 Remark: SEC34 encodes a protein of 93-kD,peripherally associated with membranes. Fractionation of yeast cytosol indicates that Sec34p and Sec35p exist in an approximately 750-kD protein complex.; Title: strong similarity to vesicle tethering protein Sec34 - Saccharomyces cerevisiae; See PMID 10562277; See PMID 11292827; uncharacterized protein 1621646 4979174 An02g06840 Aspergillus niger uncharacterized protein XP_059603404.1 1619060 R 5061 CDS An02g06850 4979175 join(1621955..1623643,1623825..1623881) IV 1 NT_166519.1 Title: similarity to hypothetical membrane protein YLR077w - Saccharomyces cerevisiae; uncharacterized protein 1623881 4979175 An02g06850 Aspergillus niger uncharacterized protein XP_059603405.1 1621955 D 5061 CDS An02g06860 4979176 join(1624182..1624226,1624358..1625998) IV 1 NT_166519.1 Catalytic activity: L-glutamate = 4-aminobutanoate + CO2.; Pathway: glutamate metabolism; alanine and aspartate metabolism; beta-alanine metabolism; taurine and hypotaurine metabolism; butanoate metabolism.; Remark: also strong similarity to glutamate decarboxylase from mouse patent WO9214485-A.; Similarity: belongs to the family of human glutamate decarboxylases.; Title: strong similarity to glutamate decarboxylase 1 - Felis silvestris catus; See PMID 10331265; See PMID 3453123; uncharacterized protein 1625998 4979176 An02g06860 Aspergillus niger uncharacterized protein XP_001399821.1 1624182 D 5061 CDS An02g06870 4979177 complement(join(1626291..1627919,1627969..1628113,1628167..1628472,1628527..1628774,1628846..1628995)) IV 1 NT_166519.1 Remark: RINT-1 human specifically binds to Rad50 only during late S and G(2)/M phases, suggesting that RINT-1 may be involved in cell cycle regulation.; Title: strong similarity to RAD50-interacting protein 1 RINT-1 - Homo sapiens; See PMID 11096100; uncharacterized protein 1628995 4979177 An02g06870 Aspergillus niger uncharacterized protein XP_001399822.1 1626291 R 5061 CDS An02g06890 4979178 1629219..1631723 IV 1 NT_166519.1 Catalytic activity: ATP + deoxyribonucleotide(N) + deoxyribonucleotide(M) <=> AMP + diphosphate + deoxyribonucleotide(N+M); Function: Catalyses the formation of a phosphodiester at the site of a single strand break in duplex DNA.; Remark: RNA can also act as substrate to some extent.; Title: strong similarity to DNA ligase cdc17p -Schizosaccharomyces pombe; uncharacterized protein 1631723 4979178 An02g06890 Aspergillus niger uncharacterized protein XP_001399823.1 1629219 D 5061 CDS An02g06900 4979179 complement(join(1632600..1633610,1633721..1633780)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein CAD60743.1 - Podospora anserina; uncharacterized protein 1633780 4979179 An02g06900 Aspergillus niger uncharacterized protein XP_001399824.1 1632600 R 5061 CDS An02g06910 4979180 join(1638630..1638941,1639002..1639097,1639186..1640923,1640982..1641108,1641167..1641263) IV 1 NT_166519.1 Title: strong similarity to hypothetical membrane protein YIL108w - Saccharomyces cerevisiae; uncharacterized protein 1641263 4979180 An02g06910 Aspergillus niger uncharacterized protein XP_001399825.1 1638630 D 5061 CDS An02g06920 84590373 complement(join(1643316..1643389,1643430..1643462,1643527..1643716)) IV 1 NT_166519.1 hypothetical protein 1643716 84590373 An02g06920 Aspergillus niger hypothetical protein XP_059603406.1 1643316 R 5061 CDS An02g06930 84590374 complement(join(1650191..1650277,1650333..1650432,1650626..1650687)) IV 1 NT_166519.1 hypothetical protein 1650687 84590374 An02g06930 Aspergillus niger hypothetical protein XP_059603407.1 1650191 R 5061 CDS An02g06940 4979183 join(1651712..1651725,1651812..1651946,1652062..1652583,1652646..1653940,1653986..1654314) IV 1 NT_166519.1 Title: similarity to transcription factor BOM - Mus musculus; nucleus; See PMID 12175488; uncharacterized protein 1654314 4979183 An02g06940 Aspergillus niger uncharacterized protein XP_059603408.1 1651712 D 5061 CDS An02g06950 84590375 join(1659182..1659239,1659287..1659343,1659408..1659494,1659547..1660007) IV 1 NT_166519.1 Catalytic activity: hydrolysis of terminal 1,4-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.; Remark: STA1 of S. cerevisiae is also known as DEX2 and MAL5.; Title: weak similarity to glucan 1,4-alpha-glucosidase precursor Sta1 - Saccharomyces cerevisiae; uncharacterized protein 1660007 84590375 An02g06950 Aspergillus niger uncharacterized protein XP_059603409.1 1659182 D 5061 CDS An02g06960 4979185 complement(join(1660398..1660422,1660524..1660562,1660629..1660917,1660977..1664289,1664341..1664367,1664421..1664741)) IV 1 NT_166519.1 Function: vacuolar protein sorting; Remark: Mutations in the yeast gene VPS41 give rise to poor growth on low iron medium, severe alterations in vacuolar morphology, and cause the missorting of membranous and soluble vacuolar proteins.; Title: strong similarity to vacuolar assembly protein VPS41 - Lycopersicon esculentum; See PMID 7596406; See PMID 9159129; uncharacterized protein 1664741 4979185 An02g06960 Aspergillus niger uncharacterized protein XP_001399830.3 1660398 R 5061 CDS An02g06970 4979186 join(1665115..1665453,1665512..1666480) IV 1 NT_166519.1 Title: similarity to hypothetical membrane protein YDR282c - Saccharomyces cerevisiae; uncharacterized protein 1666480 4979186 An02g06970 Aspergillus niger uncharacterized protein XP_001399831.1 1665115 D 5061 CDS An02g06980 4979187 join(1666946..1667199,1667296..1667590,1667646..1667838,1667889..1668196) IV 1 NT_166519.1 Remark: The enzymatic properties including base specificity of RNase Trv were very similar to those of typical T2-family RNases such as RNase T2 from Aspergillus oryzae and RNase M from A. saitoi.; Title: similarity to ribonuclease TRV - Trichoderma viride; See PMID 1794979; uncharacterized protein 1668196 4979187 An02g06980 Aspergillus niger uncharacterized protein XP_001399832.3 1666946 D 5061 CDS An02g06990 84590376 1668400..1668528 IV 1 NT_166519.1 hypothetical protein 1668528 84590376 An02g06990 Aspergillus niger hypothetical protein XP_059603410.1 1668400 D 5061 CDS An02g07000 4979189 complement(join(1669788..1671448,1671507..1672161)) IV 1 NT_166519.1 Remark: recognizes a specific sequence in the promoter of the HO gene; found in nucleus in G1 but in cytoplasm in S, G2, and M phase of cell cycle; entry into nucleus is controlled during cell cycle by phosphorylation within the nuclear localization; sequence inhibited by Ash1p in daughter cells resulting in mother cell-specific HO expression; activation of HO gene requires Swi4p/Swi6p in addition to Swi5p; dephosphorylated by Cdc14p.; Title: similarity to transcription factor Swi5 -Saccharomyces cerevisiae; See PMID 3284746; uncharacterized protein 1672161 4979189 An02g07000 Aspergillus niger uncharacterized protein XP_001399834.1 1669788 R 5061 CDS An02g07010 4979190 join(1673850..1673943,1674020..1674300,1674366..1674455) IV 1 NT_166519.1 Remark: a splice site was detected upstream of the START codon.; Remark: high homology to other polyubiquitin and CEP-80 genes at the N- and C-terminus; Remark: ubi1 of A. nidulans is a ubiquitin/ribosomal fusion protein.; Title: strong similarity to ubiquitin ubi1 -Aspergillus nidulans; cytoplasm; See PMID 10684969; uncharacterized protein 1674455 4979190 An02g07010 Aspergillus niger uncharacterized protein XP_001399835.1 1673850 D 5061 CDS An02g07020 4979191 complement(join(1674698..1675356,1675430..1675490,1675549..1675598,1675668..1675697,1675756..1676009,1676089..1676189,1676283..1676369,1676501..1676506)) IV 1 NT_166519.1 Catalytic activity: Hydrolysis of the 1,4-beta-linkages of N-acetyl-D-glucosamine polymers of chitin.; Remark: Chitinase has been suggested to play a pivotal role in autolysis of the parasitic cell wall of Coccidioides immitis during the asexual reproductive cycle (endosporulation) of this systemic pathogen. Loss of CTS1 function had no effect on virulence or endosporulation. The absence of a functional CTS1 gene can be compensated for by elevated expression of the CTS2 gene.; Title: strong similarity to chitinase 1 precursor cts1 - Coccidioides immitis; See PMID 8566773; See PMID 10992492; uncharacterized protein 1676506 4979191 An02g07020 Aspergillus niger uncharacterized protein XP_001399836.1 1674698 R 5061 CDS An02g07030 4979192 complement(join(1679430..1679558,1679621..1680018,1680085..1680097)) IV 1 NT_166519.1 hypothetical protein 1680097 4979192 An02g07030 Aspergillus niger hypothetical protein XP_001399837.1 1679430 R 5061 CDS An02g07040 4979193 complement(join(1682214..1682294,1682322..1682600,1682666..1682878,1682938..1683032,1683154..1683213,1683287..1683293)) IV 1 NT_166519.1 Localization: yeast proteasomes are mainly localized in the nuclear envelope-ER network.; Title: strong similarity to proteasome 20S subunit Scl1 - Saccharomyces cerevisiae; See PMID 9285707; See PMID 10582237; See PMID 187288; uncharacterized protein 1683293 4979193 An02g07040 Aspergillus niger uncharacterized protein XP_059603411.1 1682214 R 5061 CDS An02g07050 4979194 complement(1684096..1685355) IV 1 NT_166519.1 Remark: Homology is mainly based on repetitive sequences.; Title: weak similarity to hypothetical protein B0041.7 - Caenorhabditis elegans; uncharacterized protein 1685355 4979194 An02g07050 Aspergillus niger uncharacterized protein XP_059603412.1 1684096 R 5061 CDS An02g07060 4979195 complement(join(1685918..1687495,1687497..1689122)) IV 1 NT_166519.1 Remark: Alp6 localizes to spindle pole body (SPB) and also to the equatorial microtubule organizing centre. Alp6 may play a crucial role in the spindle pole-mediated checkpoint pathway. temperature-sensitive (ts) alp4 and alp6 mutants show two types of microtubular defects.; Title: strong similarity to gamma-tubulin-interacting protein alp6p -Schizosaccharomyces pombe; See PMID 11080156; uncharacterized protein 1689122 4979195 An02g07060 Aspergillus niger uncharacterized protein XP_059603413.1 1685918 R 5061 CDS An02g07070 4979196 complement(join(1690294..1690600,1690666..1691908,1692231..1692333)) IV 1 NT_166519.1 Remark: Atf1, and its binding site are necessary for the induction of ctt1(+) by osmotic stress, UV irradiation, and heat shock. Atf1 is activated by menadione treatment in pap1 mutant cells; Title: strong similarity to transcription factor atf1p - Schizosaccharomyces pombe; See PMID 8557039; See PMID 10102365; See PMID 10731689; uncharacterized protein 1692333 4979196 An02g07070 Aspergillus niger uncharacterized protein XP_059603414.1 1690294 R 5061 CDS An02g07080 4979197 complement(1695673..1696266) IV 1 NT_166519.1 Function: thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.; Remark: synonyms: prealbumin precursor; TBPA precursor.; Title: similarity to transthyretin precursor TTR -Rattus norvegicus; See PMID 3839240; See PMID 8246408; See PMID 1519447; uncharacterized protein 1696266 4979197 An02g07080 Aspergillus niger uncharacterized protein XP_001399842.1 1695673 R 5061 CDS An02g07090 4979198 join(1697374..1697760,1697829..1698418,1698481..1698529) IV 1 NT_166519.1 Function: ASNA1 anion-transporting atpase catalyzes the extrusion of arsenite.; Title: strong similarity to ASNA1 product arsenite translocating ATPase - Homo sapiens; See PMID 8884272; uncharacterized protein 1698529 4979198 An02g07090 Aspergillus niger uncharacterized protein XP_001399843.1 1697374 D 5061 CDS An02g07100 84590377 join(1698635..1698685,1698812..1699022,1699098..1699144) IV 1 NT_166519.1 hypothetical protein 1699144 84590377 An02g07100 Aspergillus niger hypothetical protein XP_059603415.1 1698635 D 5061 CDS An02g07110 4979200 1701418..1701615 IV 1 NT_166519.1 Remark: a splice site was detected upstream of the START codon.; hypothetical protein 1701615 4979200 An02g07110 Aspergillus niger hypothetical protein XP_001399845.3 1701418 D 5061 CDS An02g07120 4979201 complement(join(1702533..1702551,1702618..1702812,1702874..1704018)) IV 1 NT_166519.1 Function: binds to the 40s ribosome and promotes the binding of methionyl-tRNAi and mRNA.; Remark: Int-6 synonym: eukaryotic translation initiation factor 3 subunit 6.; Title: strong similarity to viral integration site protein int-6/EIF-3 P48 - Mus musculus; cytoplasm; See PMID 7853537; uncharacterized protein 1704018 4979201 An02g07120 Aspergillus niger uncharacterized protein XP_001399846.1 1702533 R 5061 CDS An02g07130 4979202 join(1704312..1704639,1704717..1705150,1705238..1705261) IV 1 NT_166519.1 Title: similarity to hypothetical neighbour-of-FAU protein NOF1 - Homo sapiens; See PMID 8786148; mitochondrial 54S ribosomal protein mL49 1705261 4979202 An02g07130 Aspergillus niger mitochondrial 54S ribosomal protein mL49 XP_059603416.1 1704312 D 5061 CDS An02g07140 4979203 complement(1706534..>1708939) IV 1 NT_166519.1 Remark: Swi1p is component of the Swi/Snf chromatin remodelling complex.; Remark: the Swi/Snf complex includes Swi1p, Snf2p,Swi3p, Snf5p, Snf6p, Snf11p and other proteins.; Title: similarity to transcription regulator Swi1 -Saccharomyces cerevisiae [truncated ORF]; nucleus; See PMID 7917331; See PMID 8939065; See PMID 3143101; uncharacterized protein 1708939 4979203 An02g07140 Aspergillus niger uncharacterized protein XP_001399848.3 1706534 R 5061 CDS An02g07150 84590378 join(<1709055..1709116,1709250..1709366,1709453..1709517,1709575..1709702,1709799..1709879,1709985..1710017,1710100..1710251,1710321..1710402,1710792..1710866) IV 1 NT_166519.1 Remark: ORF 5'truncated due to start of contig.; Similarity: the predicted A. niger protein shows similarity to several RNA-binding proteins.; Title: weak similarity to splicing coactivator subunit SRm300 - Homo sapiens [truncated ORF]; See PMID 10668804; uncharacterized protein 1710866 84590378 An02g07150 Aspergillus niger uncharacterized protein XP_059599999.1 1709055 D 5061 CDS An02g07160 4979205 join(1711069..1711212,1711336..1711686,1711750..1711851) IV 1 NT_166519.1 Catalytic activity: Maltose O-acetyltransferases catalyse the reaction, Acetyl-CoA + maltose <=> CoA + acetyl-maltose.; Function: E. coli maa acetylates glucose, maltose,mannose, galactose, and fructose in decreasing relative rates of 1, 0. 55, 0. 20, 0. 07 and 0. 04.; Remark: alternative names for E. coli maa are mac,b0459 and ylaD.; Similarity: E. coli maa belongs to the cyse/laca/lpxa/nodl family of acetyltransferases, composed of multiple repeats of [liv]-g-x(4).; Title: similarity to maltose O-acetyltransferase maa - Escherichia coli; See PMID 1856235; uncharacterized protein 1711851 4979205 An02g07160 Aspergillus niger uncharacterized protein XP_059600000.1 1711069 D 5061 CDS An02g07170 4979206 complement(join(1712033..1712050,1712085..1712721,1712777..1712910,1712967..1713274,1713327..1713770,1713829..1713841)) IV 1 NT_166519.1 Similarity: N. crassa acr-2 is a Gal4 type transcription factor with a fungal Zn(2)Cys(6) DNA-binding domain.; Similarity: the predicted A. niger protein shows similarity to several Zn(2)Cys(6) DNA-binding domain containing proteins.; Title: weak similarity to transcription factor involved in acriflavine resistance acr-2 - Neurospora crassa; See PMID 8679704; uncharacterized protein 1713841 4979206 An02g07170 Aspergillus niger uncharacterized protein XP_059600001.1 1712033 R 5061 CDS An02g07180 84590379 join(1714136..1714256,1714355..1714581) IV 1 NT_166519.1 hypothetical protein 1714581 84590379 An02g07180 Aspergillus niger hypothetical protein XP_059600002.1 1714136 D 5061 CDS An02g07190 4979208 join(1715006..1715163,1715219..1715263,1715325..1715423,1715476..1715762,1715828..1716702) IV 1 NT_166519.1 Function: A. niger tbpA is homologe to human TBP-7.; Gene-ID: tbpA; Remark: information about A. niger tbpA has not been published and is available via Swissprot and EMBL.; Similarity: A. niger tbpA belongs to the AAA family of ATPases.; Similarity: the predicted ORF is 64 amino acids longer than the A. niger tbpA protein sequence in the database, additionally three amino acids do not exactly match in the alignment.; See PMID 10664589; 26S protease regulatory subunit tbpA-Aspergillus niger 1716702 tbpA 4979208 tbpA Aspergillus niger 26S protease regulatory subunit tbpA-Aspergillus niger XP_059600003.1 1715006 D 5061 CDS An02g07200 84590380 complement(join(1716972..1717054,1717177..1717305,1717391..1717424)) IV 1 NT_166519.1 hypothetical protein 1717424 84590380 An02g07200 Aspergillus niger hypothetical protein XP_059600004.1 1716972 R 5061 CDS An02g07210 4979210 join(1717460..1717561,1717653..1717803,1717857..1718511,1718570..1718858) IV 1 NT_166519.1 Function: the intracellular protease pepE is responsible for 68% of total intracellular proteolytic activity.; Gene-ID: pepE; Mapping: pepE from A. niger is mapped to chromosome IV (LG IV); see list from DSM, PUBMED 9309173.; See PMID 9266703; aspartic protease pepE-Aspergillus niger 1718858 pepE 4979210 pepE Aspergillus niger aspartic protease pepE-Aspergillus niger XP_001399855.1 1717460 D 5061 CDS An02g07220 84590381 complement(join(1718930..1719013,1719095..1719250,1719333..1719416,1719448..1719510)) IV 1 NT_166519.1 Remark: ORF classified questionable because according to patent Q87111 the DNA-region of this predicted A. niger ORF belongs to the 5'UTR of A. niger pepE.; Title: questionable ORF; uncharacterized protein 1719510 84590381 An02g07220 Aspergillus niger uncharacterized protein XP_059600005.1 1718930 R 5061 CDS An02g07230 4979212 join(1719821..1720068,1720133..1720219,1720382..1722413) IV 1 NT_166519.1 Function: A. nidulans pod mutants have defects in establishing polar hyphal growth but are capable of nuclear division.; Function: a conditional mutation in pod40 from A. nidulans results in a polarity-defective phenotype.; Title: strong similarity to CTD phosphatase-like protein pod40 - Aspergillus nidulans; See PMID 11273680; uncharacterized protein 1722413 4979212 An02g07230 Aspergillus niger uncharacterized protein XP_059600006.1 1719821 D 5061 CDS An02g07240 4979213 complement(join(1722970..1723085,1723162..1723393)) IV 1 NT_166519.1 hypothetical protein 1723393 4979213 An02g07240 Aspergillus niger hypothetical protein XP_059600007.1 1722970 R 5061 CDS An02g07250 4979214 complement(join(1724102..1724405,1724478..1725061,1725159..1725245)) IV 1 NT_166519.1 Gene-ID: argA; Remark: by a BLASTX search argA from A. niger (EMBL: AF242315) was found: the ORF and argA from A. niger are identical in sequence, however, the ORF is N-terminal 23 amino acids longer and C-terminal 34.; Remark: depending on the growth conditions A. nidulans agaA transcripts have different 5'ends.; Similarity: the ORF is almost identical to A. nidulans arginase agaA.; See PMID 10547040; See PMID 9056996; arginase argA-Aspergillus niger 1725245 argA 4979214 argA Aspergillus niger arginase argA-Aspergillus niger XP_001399859.1 1724102 R 5061 CDS An02g07260 4979215 complement(join(1725790..1727045,1727098..1727239,1727295..1727371,1727428..1727758)) IV 1 NT_166519.1 Function: S. cerevisiae PET112 is nuclear encoded and seems to have a general function in mitochondrial gene expression, probably in translation.; Function: S. cerevisiae pet112 mutations lead to loss of mitochondrial DNA.; Function: the predicted A. niger protein, A. nidulans nempA and S. cerevisiae pet112 all show high similarity to bacterial glutamyl-tRNA amidotransferases.; Title: strong similarity to mitochondrial glutamyl-tRNA amidotransferase Pet112 - Saccharomyces cerevisiae; See PMID 8082172; See PMID 9287027; uncharacterized protein 1727758 4979215 An02g07260 Aspergillus niger uncharacterized protein XP_001399860.3 1725790 R 5061 CDS An02g07270 84590382 complement(join(1727979..1728124,1728236..1728362)) IV 1 NT_166519.1 hypothetical protein 1728362 84590382 An02g07270 Aspergillus niger hypothetical protein XP_059600008.1 1727979 R 5061 CDS An02g07280 84590383 complement(join(1728867..1728957,1729048..1729196,1729240..1729320)) IV 1 NT_166519.1 hypothetical protein 1729320 84590383 An02g07280 Aspergillus niger hypothetical protein XP_059600009.1 1728867 R 5061 CDS An02g07290 4979218 join(1729421..1730501,1730558..1730942,1730997..1731039) IV 1 NT_166519.1 Title: weak similarity to hypothetical protein encoded by An11g05410 - Aspergillus niger; uncharacterized protein 1731039 4979218 An02g07290 Aspergillus niger uncharacterized protein XP_001399863.1 1729421 D 5061 CDS An02g07300 4979219 complement(join(1732221..1734600,1734656..1734879)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein CAF05875.1 - Neurospora crassa; uncharacterized protein 1734879 4979219 An02g07300 Aspergillus niger uncharacterized protein XP_001399864.1 1732221 R 5061 CDS An02g07310 4979220 join(1735338..1735622,1735662..1739150) IV 1 NT_166519.1 hypothetical protein 1739150 4979220 An02g07310 Aspergillus niger hypothetical protein XP_059600010.1 1735338 D 5061 CDS An02g07320 4979221 join(1739358..1739695,1739763..1740333) IV 1 NT_166519.1 Catalytic activity: enoyl-CoA hydratases convert (3S)-3-hydroxyacyl-CoAc <=> trans-2(or 3)-enoyl-CoA + H(2)O.; Function: enoyl-CoA hydratases are involved in fatty acid metabolism.; Function: the decribed function of H. sapiens AUH as AU-specific RNA-binding protein may indicate a role in mRNA degradation.; Remark: also acts in the reverse direction. With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4. 2. 1. 74).; Title: strong similarity to AU-specific RNA-binding protein / enoyl-CoA hydratase AUH - Homo sapiens; uncharacterized protein 1740333 4979221 An02g07320 Aspergillus niger uncharacterized protein XP_001399866.1 1739358 D 5061 CDS An02g07330 4979222 join(1742978..1743283,1743356..1743997) IV 1 NT_166519.1 Title: similarity to hypothetical protein F17H10.1 -Caenorhabditis elegans; uncharacterized protein 1743997 4979222 An02g07330 Aspergillus niger uncharacterized protein XP_001399867.3 1742978 D 5061 CDS An02g07340 4979223 join(1744354..1744363,1744470..1747915) IV 1 NT_166519.1 Title: similarity to hypothetical protein CAE76294.1 - Neurospora crassa; uncharacterized protein 1747915 4979223 An02g07340 Aspergillus niger uncharacterized protein XP_001399868.3 1744354 D 5061 CDS An02g07350 4979224 join(1748785..1748995,1749053..1749261) IV 1 NT_166519.1 Title: weak similarity to hypothetical group 3 Lea protein MGL3 - Zea mays; uncharacterized protein 1749261 4979224 An02g07350 Aspergillus niger uncharacterized protein XP_001399869.1 1748785 D 5061 CDS An02g07360 4979225 join(1749927..1750420,1750478..1751459) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein B23L21.110 - Neurospora crassa; uncharacterized protein 1751459 4979225 An02g07360 Aspergillus niger uncharacterized protein XP_001399870.1 1749927 D 5061 CDS An02g07370 4979226 complement(1754491..1757103) IV 1 NT_166519.1 Title: similarity to hypothetical retinitis pigmentosa GTPase regulator-like protein - Takifugu rubripes retinitis; uncharacterized protein 1757103 4979226 An02g07370 Aspergillus niger uncharacterized protein XP_001399871.1 1754491 R 5061 CDS An02g07380 4979227 complement(join(1757573..1757632,1757693..1757779,1758492..1762211,1762269..1762310)) IV 1 NT_166519.1 Title: strong similarity to myosin II heavy chain -Drosophila melanogaster; cytoskeleton; uncharacterized protein 1762310 4979227 An02g07380 Aspergillus niger uncharacterized protein XP_059600011.1 1757573 R 5061 CDS An02g07390 4979228 join(1763112..1763296,1763417..1763786) IV 1 NT_166519.1 Title: strong similarity to essential protein #41 from patent WO2003076464-A2 - Aspergillus fumigatus; uncharacterized protein 1763786 4979228 An02g07390 Aspergillus niger uncharacterized protein XP_001399873.3 1763112 D 5061 CDS An02g07400 4979229 join(1767128..1767188,1767239..1767334,1767386..1767507,1767564..1767596) IV 1 NT_166519.1 Title: strong similarity to nonhistone chromosomal protein Nhp6b - Saccharomyces cerevisiae; nucleus; uncharacterized protein 1767596 4979229 An02g07400 Aspergillus niger uncharacterized protein XP_001399874.1 1767128 D 5061 CDS An02g07410 4979230 join(1770912..1771327,1771390..1771824,1771877..1771954,1772003..1772235,1772331..1772412,1772460..1772564,1772611..1772798,1772850..1772896) IV 1 NT_166519.1 hypothetical protein 1772896 4979230 An02g07410 Aspergillus niger hypothetical protein XP_059600012.1 1770912 D 5061 CDS An02g07420 4979231 complement(1773250..1774344) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein B24B19.20 - Neurospora crassa; uncharacterized protein 1774344 4979231 An02g07420 Aspergillus niger uncharacterized protein XP_001399876.1 1773250 R 5061 CDS An02g07430 4979232 join(1774610..1774640,1774761..1775842) IV 1 NT_166519.1 Function: homoserine dehydrogenases catalyze the NAD-dependent reduction of aspartate beta-semialdehyde into homoserine, which participates in the biosynthesis of threonine and then isoleucine as well as in that of methionine.; Remark: the yeast enzyme acts most rapidly with NAD(+); Neurospora enzyme with NADP(+). Enzyme from E. coli is a multifunctional protein, which also acts as aspartate kinase (EC 2. 7. 2. 4).; Title: strong similarity to homoserine dehydrogenase YJR139c - Saccharomyces cerevisiae; uncharacterized protein 1775842 4979232 An02g07430 Aspergillus niger uncharacterized protein XP_001399877.1 1774610 D 5061 CDS An02g07440 4979233 complement(join(1775934..1776164,1776254..1776984,1777057..1777189,1777242..1777343)) IV 1 NT_166519.1 Title: strong similarity to protein SEQ ID NO:7812 from patent WO200253728-A2 - Candida albicans; uncharacterized protein 1777343 4979233 An02g07440 Aspergillus niger uncharacterized protein XP_001399878.1 1775934 R 5061 CDS An02g07450 84590384 join(1777871..1777907,1777961..1778036,1778259..1778709) IV 1 NT_166519.1 hypothetical protein 1778709 84590384 An02g07450 Aspergillus niger hypothetical protein XP_059600013.1 1777871 D 5061 CDS An02g07460 4979235 complement(join(1779667..1781889,1781948..1782496,1782559..1782642)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein SPBC354.08c - Schizosaccharomyces pombe; uncharacterized protein 1782642 4979235 An02g07460 Aspergillus niger uncharacterized protein XP_001399880.1 1779667 R 5061 CDS An02g07470 4979236 complement(join(1784500..1785060,1785114..1785416,1785492..1785602,1785676..1785783)) IV 1 NT_166519.1 Catalytic activity: D-fructose 1,6-bisphosphate <=> glycerone phosphate + D-glyceraldehyde 3-phosphate, the sixth step in glycolysis.; Remark: a splice site was detected upstream of the START codon.; Remark: also acts on (3S,4R)-ketose 1-phosphates. The enzyme increases electron-attraction by the carbonyl group, some (class I) forming a protonatedimine with it,others (class II), mainly of microbial origin, polarizing it with a metal ion, e. g. zinc.; Title: strong similarity to fructose-bisphosphate aldolase Fba1 - Saccharomyces cerevisiae; cytoplasm; See PMID 1959676; uncharacterized protein 1785783 4979236 An02g07470 Aspergillus niger uncharacterized protein XP_001399881.1 1784500 R 5061 CDS An02g07480 4979237 complement(join(1786585..1787000,1787218..1788028,1788084..1788586,1788714..1788927)) IV 1 NT_166519.1 Title: strong similarity to pheromone response pathway suppressor Srm1 - Saccharomyces cerevisiae; uncharacterized protein 1788927 4979237 An02g07480 Aspergillus niger uncharacterized protein XP_001399882.3 1786585 R 5061 CDS An02g07490 4979238 complement(<1789782..1791591) IV 1 NT_166519.1 Remark: C-terminally truncated due to contig border.; Remark: the human USP21 gene is located on chromosome 1q21 and encodes a member of the ubiquitin-specific protease family with highly conserved Cys and His domains.; Title: similarity to NEDD8-specific protease USP21 -Homo sapiens [truncated ORF]; See PMID 10799498; uncharacterized protein 1791591 4979238 An02g07490 Aspergillus niger uncharacterized protein XP_059600014.1 1789782 R 5061 CDS An02g07500 4979239 complement(join(1792844..1793129,1793193..1793340,1793392..1793488,1793539..1793741,1793796..1794036,1794098..1794114,1794252..1794332,1794390..1794450)) IV 1 NT_166519.1 Catalytic activity: N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD(+) + H(2)O = L-lysine + 2-oxoglutarate + NADH.; Pathway: LYS1 from Candida albicans catalyzes the 8th step of the alpha-aminoadipate pathway of lysine biosynthesis.; Title: strong similarity to saccharopine dehydrogenase LYS1 - Candida albicans; See PMID 1429460; See PMID 7927784; uncharacterized protein 1794450 4979239 An02g07500 Aspergillus niger uncharacterized protein XP_001399884.1 1792844 R 5061 CDS An02g07510 4979240 complement(join(1794912..1795402,1795500..1795539)) IV 1 NT_166519.1 Title: weak similarity to heavy neurofilament subunit NF-H - Rattus norvegicus; uncharacterized protein 1795539 4979240 An02g07510 Aspergillus niger uncharacterized protein XP_001399885.1 1794912 R 5061 CDS An02g07520 4979241 complement(1796194..1797456) IV 1 NT_166519.1 Title: weak similarity to hypothetical anthranilate synthase trpE - Bacillus halodurans; uncharacterized protein 1797456 4979241 An02g07520 Aspergillus niger uncharacterized protein XP_001399886.1 1796194 R 5061 CDS An02g07530 4979242 join(1798636..1798936,1799013..>1799652) IV 1 NT_166519.1 Remark: C-terminally truncated due to contig border.; Remark: PspA has been shown to be immunogenic in humans and therefore may have efficacy as a human vaccine.; Remark: PspA is a serologically variable protein of Streptococcus pneumoniae that has a surface-exposed domain and a variable-length proline-rich putative cell wall-associated domain.; Remark: Similarity to PspA is based mainly on the repetitive character of the sequence (PAPA stretches).; Title: similarity to pneumococcal surface protein A PspA - Streptococcus pneumoniae [truncated ORF]; cell wall; See PMID 10992499; See PMID 11015380; uncharacterized protein 1799652 4979242 An02g07530 Aspergillus niger uncharacterized protein XP_001399887.3 1798636 D 5061 CDS An02g07550 4979244 complement(join(1803677..1804777,1804834..1804899)) IV 1 NT_166519.1 Title: similarity to hypothetical protein encoded by B9B15.005 - Neurospora crassa; uncharacterized protein 1804899 4979244 An02g07550 Aspergillus niger uncharacterized protein XP_059600015.1 1803677 R 5061 CDS An02g07560 4979245 join(1805488..1805659,1805727..1806385) IV 1 NT_166519.1 Function: RTM1 of S. cerevisiae increased the resistance to the toxicity of molasses in the growth medium.; Title: strong similarity to molasses toxicity resisitance protein RTM1 from patent WO9514774-A2 -Saccharomyces cerevisiae; uncharacterized protein 1806385 4979245 An02g07560 Aspergillus niger uncharacterized protein XP_001399889.1 1805488 D 5061 CDS An02g07570 4979246 complement(join(1807868..1808662,1808723..1808777,1808825..1809150,1809263..1809334)) IV 1 NT_166519.1 Function: KES1 of S. cerevisae plays a role in ergosterol synthesis.; Phenotype: mutations in the KES1 gene result in pleiotropic sterol-related phenotypes.; Remark: Kes1p of S. cerevisae consists of only the ligand binding domain.; Remark: inactivation of the KES1 gene resulted in the ability of yeast to survive in the absence of Sec14p,a phosphatidylinositol/phosphatidylcholine transfer protein that is normally required for cell viability due to its essential requirement in transporting vesicles from the Golgi.; Similarity: KES1 of S. cerevisae belongs to the OSBP (oxysterol binding protein) family.; Title: strong similarity to ergosterol biosynthesis protein Kes1 - Saccharomyces cerevisiae; See PMID 8017104; uncharacterized protein 1809334 4979246 An02g07570 Aspergillus niger uncharacterized protein XP_001399890.1 1807868 R 5061 CDS An02g07580 4979247 join(1811618..1812031,1812090..1812323,1812386..1813291) IV 1 NT_166519.1 Function: CYHR of C. maltosa confers resistance to cycloheximide.; Localization: CYHR of C. maltosa is an integral membrane protein.; Remark: the ORF encoded protein also shows strong similarity to a protein involved in cephalosporin C biosynthesis of Acremonium chrysogenum (Patent W14439),which is only poorly described.; Similarity: CYHR of C. maltosa belongs to the car1/cyhr subfamily.; Similarity: CYHR of C. maltosa belongs to the major facilitator family (also known as the drug resistance translocase family).; Title: strong similarity to cycloheximide resistance protein CYHR - Candida maltosa; plasma membrane; See PMID 1628836; uncharacterized protein 1813291 4979247 An02g07580 Aspergillus niger uncharacterized protein XP_001399891.3 1811618 D 5061 CDS An02g07590 4979248 join(1813993..1814028,1814094..1814216,1814304..1816355,1816432..1816800) IV 1 NT_166519.1 Function: nagA of S. thermoviolaceus hydrolyzes chitin oligosaccharides to N-acetylglucosamine.; Title: similarity to beta-N-Acetylglucosaminidase nagA - Streptomyces thermoviolaceus; See PMID 9687451; uncharacterized protein 1816800 4979248 An02g07590 Aspergillus niger uncharacterized protein XP_001399892.1 1813993 D 5061 CDS An02g07600 4979249 join(1817057..1817217,1817282..1817372,1817469..1817819,1817921..1819288) IV 1 NT_166519.1 Catalytic activity: succinate + ubiquinone = fumarate + ubiquinol.; Complex: SDH1 of S. cerevisiae forms part of complex II containing four subunits: a 70 kda flavoprotein (FP), a 27 kda iron-sulfur protein (IP), a cytochrome b and a membrane-anchoring protein.; Localization: SDH1 of S. cerevisiae forms part of the mitochondrial inner membrane.; Pathway: SDH1 of S. cerevisiae is involved tricarboxylic acid cycle.; Remark: SDH1 of S. cerevisiae uses FAD as cofactor.; Remark: SDHA, YKL148C and YKL602 are alternative names for SDH1.; Similarity: SDH1 of S. cerevisiae shows similarity to the flavoprotein subunits of bacterial succinate dehydrogenase and of fumarate reductase.; Title: strong similarity to succinate dehydrogenase Sdh1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 1511876; See PMID 1518827; uncharacterized protein 1819288 4979249 An02g07600 Aspergillus niger uncharacterized protein XP_001399893.1 1817057 D 5061 CDS An02g07610 4979250 complement(join(1820044..1820266,1820331..1820445,1820497..1821503,1821566..1821656,1821716..1821741,1821826..1822089,1822151..1822278)) IV 1 NT_166519.1 Remark: strong similarity to A. niger EST from cDNA clone 2283 5' mRNA sequenc in pYES2.; Title: strong similarity to mannitol transporter mat1 - Apium graveolens; See PMID 10759540; uncharacterized protein 1822278 4979250 An02g07610 Aspergillus niger uncharacterized protein XP_001399894.3 1820044 R 5061 CDS An02g07620 84590385 complement(join(1824136..1824496,1824571..1824835,1825089..1825141,1825189..1825217)) IV 1 NT_166519.1 hypothetical protein 1825217 84590385 An02g07620 Aspergillus niger hypothetical protein XP_059600016.1 1824136 R 5061 CDS An02g07630 84590386 join(1825400..1825567,1825764..1825995,1826083..1826158,1826206..1826355,1826437..1826498,1826549..1827317,1827391..1827451,1827656..1827663,1827729..1828458) IV 1 NT_166519.1 Title: similarity to hypothetical c-module-binding factor - Neurospora crassa; uncharacterized protein 1828458 84590386 An02g07630 Aspergillus niger uncharacterized protein XP_059600017.1 1825400 D 5061 CDS An02g07640 4979253 join(1829398..1830427,1830481..1830809,1830864..1831235) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein CAF06119.1 - Neurospora crassa; uncharacterized protein 1831235 4979253 An02g07640 Aspergillus niger uncharacterized protein XP_001399897.1 1829398 D 5061 CDS An02g07650 4979254 join(1833060..1833112,1833186..1833487,1833546..1834858) IV 1 NT_166519.1 Catalytic activity: alpha-D-Glucose 1-phosphate = alpha-D-Glucose 6-phosphate.; Catalytic activity: alpha-D-Hexose 1-phosphate = alpha-D-Hexose 6-phosphate.; Catalytic activity: alpha-D-Ribose 1-phosphate = alpha-D-Ribose 5-phosphate.; Remark: Transcription of pgmB was low during hyphal growth and in the sexual phase of development, but was significantly increased during the asexual stage of the Aspergillus nidulans life cycle.; Title: strong similarity to phosphoglucomutase pgmB - Aspergillus nidulans; See PMID 10660061; uncharacterized protein 1834858 4979254 An02g07650 Aspergillus niger uncharacterized protein XP_001399898.1 1833060 D 5061 CDS An02g07660 4979255 complement(1835081..1836688) IV 1 NT_166519.1 Remark: the ORF is longer than the StrI-related protein of D. radiodurans (535 compared to 403 amino acids).; Title: strong similarity to streptomycin biosynthesis protein StrI-related protein - Deinococcus radiodurans; See PMID 7845353; uncharacterized protein 1836688 4979255 An02g07660 Aspergillus niger uncharacterized protein XP_001399899.1 1835081 R 5061 CDS An02g07670 4979256 complement(1837157..1838857) IV 1 NT_166519.1 Remark: Similarity corresponds to multiple S-repeats.; Title: similarity to hypothetical protein K06A9.1a -Caenorhabditis elegans; uncharacterized protein 1838857 4979256 An02g07670 Aspergillus niger uncharacterized protein XP_001399900.3 1837157 R 5061 CDS An02g07680 84590387 join(1841486..1841514,1841648..1841772,1841841..1841940,1842030..1842207) IV 1 NT_166519.1 hypothetical protein 1842207 84590387 An02g07680 Aspergillus niger hypothetical protein XP_059600018.1 1841486 D 5061 CDS An02g07690 4979258 complement(join(1843415..1843471,1843557..1844041,1844106..1844183,1844257..1844291,1844406..1844477,1844555..1844568)) IV 1 NT_166519.1 Localization: Mal3 is a cytoplasmic protein that also associates with mitotic microtubule structures.; Remark: loss of the S. pombe mal3+ gene product had no gross effect on mitotic spindle morphology. overexpression of mal3+ compromised spindle formation and function and led to severe growth inhibition and abnormal cell morphology.; Similarity: the predicted A. niger protein shows strong similarity to the chromosome segregation protein Mal3 of S. pombe and EB-1 proteins from vertebrate species.; Title: strong similarity to chromosome segregation protein mal3p - Schizosaccharomyces pombe; See PMID 9348288; uncharacterized protein 1844568 4979258 An02g07690 Aspergillus niger uncharacterized protein XP_001399902.1 1843415 R 5061 CDS An02g07700 4979259 complement(join(1845115..1845863,1845981..1846087,1846143..1847146)) IV 1 NT_166519.1 Function: the receptor subunit binds specifically to pIkappaBalpha and promotes its in vitro ubiquitination,thus allowing the pIkappaBalpha-ubiquitin ligase to mark proteins for degradation by the proteasome system.; Remark: the H. sapiens b-TRCP variant E3RS-IkappaB is a receptor component of IkappaBa-ubiquitin ligase.; Remark: the H. sapiens b-TRCP variant E3RS-IkappaB protein contains beta-transducin repeats, F-box and WD regions.; Title: similarity to b-TRCP variant E3RS-IkappaB -Homo sapiens; See PMID 9859996; uncharacterized protein 1847146 4979259 An02g07700 Aspergillus niger uncharacterized protein XP_059600019.1 1845115 R 5061 CDS An02g07710 4979260 complement(join(1848758..1849022,1849082..1849172,1849235..1849916,1850030..1850158,1850210..1850233)) IV 1 NT_166519.1 Title: similarity to hypothetical protein encoded by Z2629 - Escherichia coli; uncharacterized protein 1850233 4979260 An02g07710 Aspergillus niger uncharacterized protein XP_059600020.1 1848758 R 5061 CDS An02g07720 4979261 1850933..1851898 IV 1 NT_166519.1 Catalytic activity: L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H(2)O.; Function: catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate.; Pathway: first step in diaminopimelate and lysine biosynthesis.; Title: similarity to dihydrodipicolinate synthase dapA - Escherichia coli; uncharacterized protein 1851898 4979261 An02g07720 Aspergillus niger uncharacterized protein XP_001399905.3 1850933 D 5061 CDS An02g07730 4979262 complement(join(1853567..1853707,1853756..1854941,1854972..>1855306)) IV 1 NT_166519.1 Function: isoform 1 of ING1 from M. musculus inhibits p53-dependent transcriptional activation and may function as an oncoprotein.; Function: isoform 2 of ING1 from M. musculus acts as a negative growth regulator by cooperating with p53 in transcriptional activation of p53-responsive genes and may act as a tumor suppressor.; Remark: 5'-truncated ORF due to end of contig.; Remark: ING1 from M. musculus contains 1 phd-finger domain.; Remark: ING1 from M. musculus is found in 2 isoforms produced by alternative splicing.; Remark: ING1 is widely expressed with highest levels in thymus and testis in the adult mouse.; Title: similarity to growth regulator ING1 - Mus musculus [truncated ORF]; See PMID 9440695; See PMID 10542254; See PMID 11461112; See PMID 9102209; uncharacterized protein 1855306 4979262 An02g07730 Aspergillus niger uncharacterized protein XP_059600021.1 1853567 R 5061 CDS An02g07740 4979263 join(1857294..1857376,1857432..1857894,1857951..1858145,1858196..1858486) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein SPAC1952.10c - Schizosaccharomyces pombe; uncharacterized protein 1858486 4979263 An02g07740 Aspergillus niger uncharacterized protein XP_001399907.1 1857294 D 5061 CDS An02g07750 4979264 1860021..1860845 IV 1 NT_166519.1 Title: similarity to hypothetical protein SPAC2C4.08 - Schizosaccharomyces pombe; uncharacterized protein 1860845 4979264 An02g07750 Aspergillus niger uncharacterized protein XP_001399908.3 1860021 D 5061 CDS An02g07760 4979265 join(1861449..1861968,1862011..1862131,1862428..1862485) IV 1 NT_166519.1 Title: similarity to hypothetical transcription regulator PAB1642 - Pyrococcus abyssi; uncharacterized protein 1862485 4979265 An02g07760 Aspergillus niger uncharacterized protein XP_059600022.1 1861449 D 5061 CDS An02g07770 4979266 complement(join(1863882..1864582,1864649..1864758,1864811..1865275,1865335..1865610,1865661..1866070,1866130..1866234)) IV 1 NT_166519.1 Catalytic activity: trehalose synthase catalyzes the trehalose synthesis from alpha-D-glucose 1-phosphate and D-glucose.; Remark: TSase and TSase synthase are alternative names for trehalose synthase.; Title: strong similarity to trehalose synthase TSase - Grifola frondosa; See PMID 9763690; uncharacterized protein 1866234 4979266 An02g07770 Aspergillus niger uncharacterized protein XP_001399910.1 1863882 R 5061 CDS An02g07780 4979267 join(1867522..1867615,1867685..1867843,1867915..1868061,1868124..1868236,1868292..1868333) IV 1 NT_166519.1 Function: ARFs are GTP-binding proteins that function as an allosteric activators of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. ARFs are involved in protein trafficking they may modulate vesicle budding and uncoating within the golgi apparatus.; Similarity: ARF6 of H. sapiens belongs to the ARF family of GTP-binding proteins.; Title: strong similarity to ADP-ribosylation factor 6 ARF6 - Homo sapiens; See PMID 1993656; uncharacterized protein 1868333 4979267 An02g07780 Aspergillus niger uncharacterized protein XP_001399911.1 1867522 D 5061 CDS An02g07790 4979268 join(1869305..1869353,1869484..1869596,1869670..1869738) IV 1 NT_166519.1 Title: similarity to hypothetical protein B3E4.280 -Neurospora crassa; uncharacterized protein 1869738 4979268 An02g07790 Aspergillus niger uncharacterized protein XP_001399912.1 1869305 D 5061 CDS An02g07800 4979269 complement(join(1870123..1870694,1870756..1871172,1871241..1871460)) IV 1 NT_166519.1 Remark: the ORF encoded protein also shows strong similarity to one of the proteins from patent Y34744, that represents the proteins encoded by all the open reading frames in the complete genome of Chlamydia pneumoniae.; Title: strong similarity to hypothetical protein CP0630 - Chlamydophila pneumoniae; uncharacterized protein 1871460 4979269 An02g07800 Aspergillus niger uncharacterized protein XP_001399913.1 1870123 R 5061 CDS An02g07810 84590388 join(1871865..1871904,1872141..1872250) IV 1 NT_166519.1 Title: questionable ORF; uncharacterized protein 1872250 84590388 An02g07810 Aspergillus niger uncharacterized protein XP_059600023.1 1871865 D 5061 CDS An02g07820 10098260 join(1872647..1873781,1873853..1873857,1873958..1873985,1874132..1874241,1874356..1874748,1874898..1875627,1875745..1875770) IV 1 NT_166519.1 hypothetical protein 1875770 10098260 An02g07820 Aspergillus niger hypothetical protein XP_059600024.1 1872647 D 5061 CDS An02g07830 4979272 complement(join(1876081..1877138,1877198..1878788)) IV 1 NT_166519.1 Function: the PHD finger, is a C4HC3 zinc-finger-like motif found in nuclear proteins thought to be involved in chromatin-mediated transcriptional regulation.; Similarity: the ORF encoded protein also shows similarity to several hypothetical and known phd finger transcription regulators; the region of similarity is restricted to the phd-domain.; Title: similarity to hypothetical phd finger transcription regulator - Schizosaccharomyces pombe; nucleus; uncharacterized protein 1878788 4979272 An02g07830 Aspergillus niger uncharacterized protein XP_059600025.1 1876081 R 5061 CDS An02g07840 4979273 join(1881288..1881580,1881632..1883261) IV 1 NT_166519.1 Title: weak similarity to hypothetical protein encoded by An14g03700 - Aspergillus niger; uncharacterized protein 1883261 4979273 An02g07840 Aspergillus niger uncharacterized protein XP_059600026.1 1881288 D 5061 CDS An02g07850 4979274 complement(join(1883691..1884734,1884826..1884906,1884974..1885176,1885238..1885406)) IV 1 NT_166519.1 Phenotype: Disruption strains showed much-reduced uptake of glucose at low concentrations and growth was particularly affected in low-glucose medium.; Similarity: the ORF encoded protein also shows similarity to other hexose transporters.; Title: strong similarity to high-affinity glucose transporter HGT1 - Kluyveromyces lactis; plasma membrane; See PMID 8830679; uncharacterized protein 1885406 4979274 An02g07850 Aspergillus niger uncharacterized protein XP_059600027.1 1883691 R 5061 CDS An02g07860 4979275 join(1887421..1887700,1887766..1888570,1888643..1889254,1889307..1890762) IV 1 NT_166519.1 Remark: a splice site was detected upstream of the START codon.; Remark: the facB gene of Aspergillus nidulans is a major regulatory gene involved in acetamide and acetate utilisation.; Similarity: belongs to Zn[2]-Cys[6] fungal-type binuclear cluster proteins.; Title: strong similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; nucleus; See PMID 9197408; See PMID 9524126; See PMID 10483720; uncharacterized protein 1890762 4979275 An02g07860 Aspergillus niger uncharacterized protein XP_001399919.1 1887421 D 5061 CDS An02g07870 4979276 complement(join(1890924..1890942,1891063..1891617,1891692..1891999)) IV 1 NT_166519.1 Catalytic activity: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2.; Pathway: arginine and proline metabolism.; Remark: prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline in collagens.; Remark: the recently identified peptide-binding domain showed a relatively low identity to those from other species, and the Km of the Drosophila enzyme for (Pro-Pro-Gly)10 was higher than that of any other animal prolyl 4-hydroxylase studied.; Title: similarity to prolyl-4-hydroxylase-alpha -Drosophila melanogaster; See PMID 10037780; uncharacterized protein 1891999 4979276 An02g07870 Aspergillus niger uncharacterized protein XP_001399920.3 1890924 R 5061 CDS An02g07880 4979277 join(1894109..1894648,1894754..1895464,1895531..1895890) IV 1 NT_166519.1 Remark: QUTD gene encodes an essential component of a permease required for transport of quinate ion into mycelium at pH 6. 5. The QUTD gene has been located within the cloned QUT gene cluster of A. nidulans.; Similarity: belongs to the sugar transporter family.; Title: strong similarity to quinate transport protein qutD - Aspergillus nidulans; See PMID 2835177; See PMID 2976880; uncharacterized protein 1895890 4979277 An02g07880 Aspergillus niger uncharacterized protein XP_001399921.1 1894109 D 5061 CDS An02g07890 4979278 join(1897956..1898219,1898359..1898647,1898701..1900151) IV 1 NT_166519.1 Gene-ID: pacC; Mapping: pacC from A. niger is mapped to chromosome IV (LG IV); see list from DSM, PUBMED 8709960.; Remark: identical to pacC A. niger patent WO9925735-A1.; Remark: the Aspergillus PacC zinc finger transcription factor mediates regulation of both acid- and alkaline-expressed genes by ambient pH.; Remark: the differences in the sequence are caused by strain variations or sequencing errors.; nucleus; See PMID 8602152; transcription factor pacC-Aspergillus niger 1900151 pacC 4979278 pacC Aspergillus niger transcription factor pacC-Aspergillus niger XP_001399922.1 1897956 D 5061 CDS An02g07900 4979279 join(1902309..1902422,1902484..1903509,1903561..1904438,1904507..1904575,1904656..1904695) IV 1 NT_166519.1 Remark: FKH2 S. cerevisiae, caused a form of yeast pseudohyphal growth.; Remark: Fkh2p assembles into ternary complexes with Mcm1p on both the SWI5 and CLB2 cell-cycle-regulated upstream activating sequence (UAS) elements in vitro, and in an Mcm1 p-dependent manner in vivo.; Remark: investigation of the relationship between Fkh2 and a related forkhead protein Fkh1 demonstrates that these proteins act in overlapping pathways to regulate cell morphology and cell separation.; Title: strong similarity to fork head 2 protein Fkh2 - Saccharomyces cerevisiae; See PMID 10747051; See PMID 10894548; See PMID 10899128; See PMID 10959837; uncharacterized protein 1904695 4979279 An02g07900 Aspergillus niger uncharacterized protein XP_001399923.3 1902309 D 5061 CDS An02g07910 4979280 complement(join(1906778..1907247,1907303..1907777,1908056..1908168,1908206..1908260)) IV 1 NT_166519.1 Remark: SLG1 S. cerevisiae plays a regulatory role in bud emergence or stationary phase.; Title: similarity to hypothetical protein Slg1 -Saccharomyces cerevisiae; See PMID 8896276; See PMID 10660075; uncharacterized protein 1908260 4979280 An02g07910 Aspergillus niger uncharacterized protein XP_059600028.1 1906778 R 5061 CDS An02g07920 84590389 complement(join(1909078..1909154,1909399..1909840)) IV 1 NT_166519.1 Title: weak similarity to hypothetical stringent starvation protein B PA4427 - Pseudomonas aeruginosa; uncharacterized protein 1909840 84590389 An02g07920 Aspergillus niger uncharacterized protein XP_059600029.1 1909078 R 5061 CDS An02g07930 4979282 complement(join(1911356..1911417,1911473..1911752,1911802..1912038,1912091..1912505,1912559..1913046,1913099..1913442,1913492..1913822,1913874..1913964,1914020..1914160,1914215..1914419,1914473..1914714,1914771..1914868,1914933..1915331)) IV 1 NT_166519.1 Remark: linoleate diol synthase from Gaeumannomyces graminis is a homotetrameric ferric hemeprotein, which catalyzes dioxygenation of linoleic acid to (8R)-hydroperoxylinoleate and isomerization of the hydroperoxide to (7S,8S)-dihydroxylinoleate. Ferryl intermediates and a tyrosyl radical are formed in the reaction.; Similarity: belongs to a gene family of fatty acid heme dioxygenases.; Title: strong similarity to precursor of linoleate diol synthase - Gaeumannomyces graminis; See PMID 10497176; uncharacterized protein 1915331 4979282 An02g07930 Aspergillus niger uncharacterized protein XP_001399926.1 1911356 R 5061 CDS An02g07940 4979283 join(1919085..1919210,1919293..1921095) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein YEL023c - Saccharomyces cerevisiae; uncharacterized protein 1921095 4979283 An02g07940 Aspergillus niger uncharacterized protein XP_001399927.1 1919085 D 5061 CDS An02g07950 4979284 complement(join(1921720..1922847,1922917..1923003)) IV 1 NT_166519.1 Remark: shows similarity also to E. nidulans sterigmatocystin synthesis transcription regulator aflR.; Remark: the S. cerevisiae protein is a transcriptional activator, necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4).; Similarity: belongs to unassigned GAL4-type zinc cluster proteins; GAL4 zinc binuclear cluster homology.; Title: similarity to regulator protein Uga3 -Saccharomyces cerevisiae; See PMID 2109179; uncharacterized protein 1923003 4979284 An02g07950 Aspergillus niger uncharacterized protein XP_001399928.1 1921720 R 5061 CDS An02g07960 4979285 complement(join(1923822..1923994,1924060..1924180,1924240..1924331,1924407..1924512,1924569..1924716,1924787..1925134,1925191..1925299,1925356..1925501,1925641..1925868,1925905..1926263,1926320..1926474,1926531..1926731,1926809..1927007)) IV 1 NT_166519.1 Remark: sterol glycosyltransferase (SGT) isolated from A. thaliana is used in a method to produce transgenic plants which have a better tolerance of/resistance against adverse environmental factors such as drought, high salt content of the soil, cold/frost and fungal attack using recombinant SGT.; Remark: strong similarity to A. thaliana protein containing sterol glycosyltransferase patent WO9817789-A1.; Title: strong similarity to sterol glycosyltransferase SGT from patent WO9817789-A1 -Arabidopsis thaliana; uncharacterized protein 1927007 4979285 An02g07960 Aspergillus niger uncharacterized protein XP_059600030.1 1923822 R 5061 CDS An02g07970 4979286 join(1927762..1927924,1927995..1928237,1928300..1928766) IV 1 NT_166519.1 Remark: RTA1 from S. cerevisiae led to strong resistance to 7-aminocholesterol a strong inhibitor of yeast and of Gram+-bacteria proliferation.; Remark: the protein shows also strong similarity to molasses toxicity resisitance protein RTM1 from S. cerevisiae patent WO9514774-A2.; Title: strong similarity to 7-aminocholesterol resistance protein Rta1 - Saccharomyces cerevisiae; See PMID 8660468; See PMID 7672593; uncharacterized protein 1928766 4979286 An02g07970 Aspergillus niger uncharacterized protein XP_001399930.1 1927762 D 5061 CDS An02g07980 4979287 complement(join(1929326..1929369,1929507..1929770,1929841..1930049,1930107..1930801,1930858..1931211)) IV 1 NT_166519.1 Remark: strong similarity to Microdochium nivale carbohydrate oxidase patent WO9931990-A1.; Remark: the M. nivale CHO oxidase has an oxidizing activity on maltotetraose which is at least twice as much as the oxidizing activity on glucose at a substrate concentration of 0. 83 mM. The CHO can oxidase the reducing end of an oligosaccharide more efficiently than the corresponding monosaccharide, e. g. preferentially oxidizing maltodextrins or cellodextrins over glucose.; Title: strong similarity to carbohydrate oxidase CHO from patent WO9931990-A1 - Microdochium nivale; uncharacterized protein 1931211 4979287 An02g07980 Aspergillus niger uncharacterized protein XP_001399931.3 1929326 R 5061 CDS An02g07990 84590390 join(1934111..1934207,1934280..1934422) IV 1 NT_166519.1 hypothetical protein 1934422 84590390 An02g07990 Aspergillus niger hypothetical protein XP_059600031.1 1934111 D 5061 CDS An02g08000 4979289 join(1939295..1939424,1939496..1939680,1939778..1939941,1939996..1940254,1940318..1940659) IV 1 NT_166519.1 Remark: heterotrimeric G proteins, consisting of alpha, beta, and gamma subunits, are implicated in major signal transduction pathways controlling a diversity of functions in eukaryotic organisms.; Remark: in the filamentous fungus Neurospora crassa,G proteins are implicated in the regulation of several environmental responses.; Similarity: belongs to the g-alpha family. belongs to subfamily 3 (g(q).; Title: strong similarity to G protein alpha chain Gna-1 - Neurospora crassa; See PMID 8325859; uncharacterized protein 1940659 4979289 An02g08000 Aspergillus niger uncharacterized protein XP_001399933.1 1939295 D 5061 CDS An02g08010 4979290 join(1941475..1941910,1941986..1942683) IV 1 NT_166519.1 Remark: only serine rich proteins are matching.; Title: similarity to hypothetical serine-rich protein SPBC215.13 - Schizosaccharomyces pombe; mitochondrial 37S ribosomal protein mS38 1942683 4979290 An02g08010 Aspergillus niger mitochondrial 37S ribosomal protein mS38 XP_001399934.1 1941475 D 5061 CDS An02g08020 4979291 complement(join(1943838..1943902,1943964..1944067,1944131..1944287,1944376..1944505,1944653..1944665,1944788..1944804)) IV 1 NT_166519.1 Catalytic activity: ATP + H2O = ADP + Orthophosphate.; Pathway: oxidative phosphorylation.; Remark: a group of enzymes from the plasma membranes of yeast and Neurospora. They are closely related to the H+/K+-transporting ATPases (EC 3. 6. 1. 36), have a single catalytic sub-unit (100 kDa) and form phosphoenyzme intermediates.; Title: strong similarity to H+-transporting ATPase lipid-binding protein vma3 - Neurospora crassa; See PMID 8190074; uncharacterized protein 1944804 4979291 An02g08020 Aspergillus niger uncharacterized protein XP_001399935.1 1943838 R 5061 CDS An02g08030 4979292 join(1948353..1948369,1948538..1948672,1948767..1949007) IV 1 NT_166519.1 Remark: during the life cycle of P. infestans, ric1 was expressed in all developmental stages but the level of expression varied. Sporangia and germinating cysts appeared to contain only very little ric1 mRNA whereas in the mycelium and during in planta growth higher levels were detected. Subjecting the mycelium to osmotic stress or to a high pH resulted in increased ric1 expression.; Title: similarity to membrane spanning protein RIC1 - Phytophthora infestans; See PMID 10591972; uncharacterized protein 1949007 4979292 An02g08030 Aspergillus niger uncharacterized protein XP_059600032.1 1948353 D 5061 CDS An02g08040 4979293 1950475..1952208 IV 1 NT_166519.1 Remark: only a serin threonin rich region is matching.; hypothetical protein 1952208 4979293 An02g08040 Aspergillus niger hypothetical protein XP_001399937.3 1950475 D 5061 CDS An02g08050 4979294 join(1954512..1954879,1954958..1955918) IV 1 NT_166519.1 Title: similarity to hypothetical phosphatidyl synthase SPAC22A12.08c - Schizosaccharomyces pombe; uncharacterized protein 1955918 4979294 An02g08050 Aspergillus niger uncharacterized protein XP_001399938.1 1954512 D 5061 CDS An02g08060 4979295 complement(join(1956375..1957701,1957759..1957832)) IV 1 NT_166519.1 Remark: no obvious phenotypes could be attributed to YGL144c.; Title: similarity to hypothetical protein YGL144c -Saccharomyces cerevisiae; See PMID 10806424; uncharacterized protein 1957832 4979295 An02g08060 Aspergillus niger uncharacterized protein XP_001399939.1 1956375 R 5061 CDS An02g08070 4979296 1958731..1960701 IV 1 NT_166519.1 Remark: mutants exhibit RNase MRP RNA processing defect; functions redundantly with REX1 and REX2 in U5 snRNA and RNase P RNA processing.; Remark: the biogenesis of a number of RNA species in eukaryotic cells requires 3' processing.; Remark: the length to the REX3 protein is differnt but due to the similarity to other exonucleases the function seems clear.; Similarity: part of family of 3'- to 5' exonucleases.; Title: similarity to 3-5 exonuclease Rex3 -Saccharomyces cerevisiae; See PMID 10716935; uncharacterized protein 1960701 4979296 An02g08070 Aspergillus niger uncharacterized protein XP_059600033.1 1958731 D 5061 CDS An02g08080 4979297 complement(join(1961128..1961254,1961317..1961513,1961584..1961619,1961788..1961802)) IV 1 NT_166519.1 Remark: X. laevis L22 mRNA is a example of the correlation between the polypyrimidine terminal tract and the translational regulation observed in other rp mRNAs.; Similarity: belongs to the ribosomal protein L22 protein family.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L22 - Xenopus laevis; cytoplasm; See PMID 7890164; 60S ribosomal protein eL22 1961802 4979297 An02g08080 Aspergillus niger 60S ribosomal protein eL22 XP_001399941.1 1961128 R 5061 CDS An02g08090 4979298 join(1962659..1962739,1962807..1962840,1962902..1962949,1963038..1963280,1963355..1963380) IV 1 NT_166519.1 Remark: Dim1p plays a role in mitotic spindle formation and/or function.; Remark: Dim1p strongly inhibits the pre-rRNA processing steps that lead to the synthesis of 18S rRNA.; Title: strong similarity to essential for mitosis protein dim1p - Schizosaccharomyces pombe; See PMID 9528805; See PMID 9182666; uncharacterized protein 1963380 4979298 An02g08090 Aspergillus niger uncharacterized protein XP_001399942.1 1962659 D 5061 CDS An02g08100 4979299 join(1963875..1963940,1964149..1964202,1964253..1964423,1964465..1964570,1964649..1964734,1964802..1964951,1965006..1965080) IV 1 NT_166519.1 Function: translin is a recombination hotspot binding protein, which specifically binds to consensus sequences at breakpoint junctions of chromosomal translocations in many cases of lymphoid malignancies.; Title: strong similarity to translin-like protein TRAX - Gallus gallus; See PMID 9244443; See PMID 9013868; uncharacterized protein 1965080 4979299 An02g08100 Aspergillus niger uncharacterized protein XP_059600034.1 1963875 D 5061 CDS An02g08110 4979300 complement(join(1965332..1965858,1965944..1965986)) IV 1 NT_166519.1 Catalytic activity: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O.; Function: may constitute a glutathionine peroxidase-like protective system against oxidative stresses.; Pathway: glutathione metabolism.; Remark: a protein containing a selenocysteine residue. Steroid and lipid hydroperoxides, but not the product of reaction of EC 1. 13. 11. 12 on phospholipids,can act as acceptor, but more slowly than H2O2.; Similarity: belongs to the glutathione peroxidase family.; Title: strong similarity to glutathione peroxidase Hyr1 - Saccharomyces cerevisiae; See PMID 10480913; uncharacterized protein 1965986 4979300 An02g08110 Aspergillus niger uncharacterized protein XP_001399944.3 1965332 R 5061 CDS An02g08120 4979301 complement(join(1967258..1967549,1967618..1967817)) IV 1 NT_166519.1 hypothetical protein 1967817 4979301 An02g08120 Aspergillus niger hypothetical protein XP_001399945.3 1967258 R 5061 CDS An02g08130 4979302 complement(join(1968326..1968366,1968417..1968470,1968524..1968595,1968644..1968964,1969025..1969211)) IV 1 NT_166519.1 Title: similarity to hypothetical protein 2SCG18.24 - Streptomyces coelicolor; uncharacterized protein 1969211 4979302 An02g08130 Aspergillus niger uncharacterized protein XP_001399946.1 1968326 R 5061 CDS An02g08140 4979303 join(1972038..1972083,1972133..1972730,1972781..1974023) IV 1 NT_166519.1 Catalytic activity: protein tyrosine phosphate + H2O = protein tyrosine + orthophosphate.; Remark: CDC14 S. cerevisiae encodes a phosphotyrosine phosphatase (PTPase) and is essential for termination of M phase.; Similarity: belongs to the non-receptor class of the protein-tyrosine phosphatase family. cdc14 subfamily.; Title: strong similarity to protein-tyrosine-phosphatase Cdc14 - Saccharomyces cerevisiae; See PMID 10801456; See PMID 1597462; See PMID 8668128; uncharacterized protein 1974023 4979303 An02g08140 Aspergillus niger uncharacterized protein XP_059600035.1 1972038 D 5061 CDS An02g08160 4979305 complement(join(1975419..1975668,1975750..1975975,1976076..1976214)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein PA2804 - Pseudomonas aeruginosa; uncharacterized protein 1976214 4979305 An02g08160 Aspergillus niger uncharacterized protein XP_001399948.1 1975419 R 5061 CDS An02g08170 4979306 complement(join(1976616..1976875,1976933..1977151,1977205..1977379,1977439..1977612)) IV 1 NT_166519.1 Remark: also strong similarity to Penicillium decumbens epoxidation enzyme patent JP08322560-A.; Remark: the enzyme converts the phosphomycin precursor (z)-1-propenyl phosphonic acid into the antibiotic phosphomycin.; Title: strong similarity to epoxidase subunit A epoA - Penicillium decumbens; See PMID 10049860; uncharacterized protein 1977612 4979306 An02g08170 Aspergillus niger uncharacterized protein XP_001399949.1 1976616 R 5061 CDS An02g08180 4979307 join(1978379..1978571,1978608..1978680,1978744..1978938,1978996..1979161,1979221..1979322,1979373..1979502,1979557..1979669,1979727..1980281) IV 1 NT_166519.1 Remark: GIT1 gene encodes a permease involved in the uptake of glycerophosphoinositol.; Title: strong similarity to glycerophosphoinositol transporter Git1 - Saccharomyces cerevisiae; See PMID 9691030; uncharacterized protein 1980281 4979307 An02g08180 Aspergillus niger uncharacterized protein XP_059600036.1 1978379 D 5061 CDS An02g08190 84590391 complement(join(1980476..1980574,1980612..1981560,1981619..1981653)) IV 1 NT_166519.1 Title: weak similarity to hypothetical membrane protein Upc2 - Saccharomyces cerevisiae; See PMID 9696767; uncharacterized protein 1981653 84590391 An02g08190 Aspergillus niger uncharacterized protein XP_059600037.1 1980476 R 5061 CDS An02g08200 4979309 join(1982252..1982636,1982685..1983352) IV 1 NT_166519.1 Remark: there is also similarity to rape abscission/dehiscence protein Brassica napus patent WO9423043-A.; Similarity: belongs to ribitol dehydrogenase family and shows homology to short-chain alcohol dehydrogenase.; Title: similarity to developmental abscission/dehiscence protein SAC25 - Brassica napus; See PMID 8111020; uncharacterized protein 1983352 4979309 An02g08200 Aspergillus niger uncharacterized protein XP_001399952.1 1982252 D 5061 CDS An02g08210 4979310 join(1984012..1984128,1984189..1984229,1984401..1984516,1984621..1984702,1984773..1985509,1985589..1986012,1986079..1986370,1986428..1986784) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein EAA61130.1 - Aspergillus nidulans; uncharacterized protein 1986784 4979310 An02g08210 Aspergillus niger uncharacterized protein XP_001399953.3 1984012 D 5061 CDS An02g08220 4979311 1989012..1990016 IV 1 NT_166519.1 Catalytic activity: 2-Hydroxy-4-oxobutane-1,2,4-tricarboxylate = (E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H2O.; Pathway: metabolic pathway for dissimilation of protocatechuate.; Remark: ligJ from Sphingomonas paucimobilis gene is essential to the degradation of vanillate and syringate.; Title: similarity to 4-oxalomesaconate hydratase ligJ - Sphingomonas paucimobilis; See PMID 11092855; uncharacterized protein 1990016 4979311 An02g08220 Aspergillus niger uncharacterized protein XP_001399954.1 1989012 D 5061 CDS An02g08230 4979312 complement(join(1990227..1990396,1990491..1990651,1990721..1991080,1991151..1991471,1991541..1991820,1991892..1992069)) IV 1 NT_166519.1 Function: high affinity glucose transporter.; Remark: expression of HGT1 from Kluyveromyces lactis is constitutive (in contrast to RAG1, the major gene for low-affinity glucose uptake in K. lactis) and is controlled by several genes also known to affect expression of RAG1.; Similarity: belongs to the sugar transporter family.; Title: strong similarity to high affinity glucose transporter HGT1 - Kluyveromyces lactis; See PMID 8830679; uncharacterized protein 1992069 4979312 An02g08230 Aspergillus niger uncharacterized protein XP_001399955.1 1990227 R 5061 CDS An02g08240 84590392 join(1994237..1994424,1994658..1994958) IV 1 NT_166519.1 Title: strong similarity to EST an_3059 -Aspergillus niger; uncharacterized protein 1994958 84590392 An02g08240 Aspergillus niger uncharacterized protein XP_059600038.1 1994237 D 5061 CDS An02g08250 4979314 join(1995023..1995036,1995087..1995907,1995978..1996378) IV 1 NT_166519.1 Remark: putative cation efflux system protein.; Title: strong similarity to hypothetical protein F12L6.11 - Arabidopsis thaliana; uncharacterized protein 1996378 4979314 An02g08250 Aspergillus niger uncharacterized protein XP_001399957.3 1995023 D 5061 CDS An02g08260 4979315 join(1997083..1997264,1997354..1997465,1997530..1998969) IV 1 NT_166519.1 Remark: Yox1 binding to the leucine tRNA gene is necessary for the in vivo regulation of the gene and its suggests that the YOX1 gene codes for a non-essential product.; Similarity: belongs to the family of homeobox proteins.; Title: similarity to homeotic protein Yox1 -Saccharomyces cerevisiae; See PMID 8096171; uncharacterized protein 1998969 4979315 An02g08260 Aspergillus niger uncharacterized protein XP_001399958.1 1997083 D 5061 CDS An02g08270 4979316 join(1999852..1999977,2000032..2000069,2000138..2000526,2000582..2001579) IV 1 NT_166519.1 Catalytic activity: N1-acetylspermine + O2 + H2O = N1-acetylspermidine + 3-aminopropanal + H2O2.; Remark: acetylspermidine oxidase (ASOD) catalyzes the oxidation of N-acetylated spermidine in polyamine metabolism.; Similarity: belongs to the family of FAD-containing amine oxidases.; Title: strong similarity to acetylspermidine oxidase ASOD - Candida boidinii; See PMID 10913603; uncharacterized protein 2001579 4979316 An02g08270 Aspergillus niger uncharacterized protein XP_001399959.3 1999852 D 5061 CDS An02g08280 4979317 complement(2002568..2003551) IV 1 NT_166519.1 Remark: there is only homolgy to one element of DNA-directed RNA polymerase II large subunit in different orgenisms.; Title: weak similarity to DNA-directed RNA polymerase II large chain ama-1 - Caenorhabditis elegans; See PMID 2586513; uncharacterized protein 2003551 4979317 An02g08280 Aspergillus niger uncharacterized protein XP_001399960.3 2002568 R 5061 CDS An02g08290 4979318 complement(join(2006472..2010958,2011038..2011683,2011745..2014772,2014826..2016372,2016433..2017079,2017203..2018571)) IV 1 NT_166519.1 Remark: according to PMID:10334994, the lovB gene encodes LNKS (14), containing the six domains characteristic of PKSs (Fig. 2), an integrated methyltransferase domain located between the AT and the KR domain, and a domain at the COOH-terminus that is similar to the condensation domain of nonribosomal peptide synthetases (NRPSs).; Title: strong similarity to lovastatin nonaketide synthase lovB - Aspergillus terreus; See PMID 10334994; See PMID 11386351; uncharacterized protein 2018571 4979318 An02g08290 Aspergillus niger uncharacterized protein XP_059600039.1 2006472 R 5061 CDS An02g08300 4979319 join(2019329..2019484,2019559..2019897) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein encoded by An11g06450 - Aspergillus niger; uncharacterized protein 2019897 4979319 An02g08300 Aspergillus niger uncharacterized protein XP_001399962.3 2019329 D 5061 CDS An02g08310 4979320 complement(2020047..2021096) IV 1 NT_166519.1 Remark: the LNKS and (at least) the LovC proteins interact to produce a polyketide of the correct length and with the correct reduction and cyclization pattern.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994; uncharacterized protein 2021096 4979320 An02g08310 Aspergillus niger uncharacterized protein XP_001399963.1 2020047 R 5061 CDS An02g08320 4979321 join(2021545..2021808,2021897..2022775) IV 1 NT_166519.1 Remark: the protein is only the half of the length of PTH11.; Title: weak similarity to integral membrane protein PTH11 from patent WO9913094-A2 - Magnaporthe grisea; See PMID 10521529; uncharacterized protein 2022775 4979321 An02g08320 Aspergillus niger uncharacterized protein XP_001399964.1 2021545 D 5061 CDS An02g08330 4979322 join(2023391..2023560,2023633..2025058) IV 1 NT_166519.1 Similarity: the ORF shows similarity to several multidrug-efflux transporters.; Title: strong similarity to sequence 253 from patent WO0100804 - Corynebacterium glutamicum; uncharacterized protein 2025058 4979322 An02g08330 Aspergillus niger uncharacterized protein XP_001399965.1 2023391 D 5061 CDS An02g08340 4979323 complement(join(2025837..2026288,2026340..2026660,2026717..2027088,2027149..2027368,2027402..2027446,2027671..2027769)) IV 1 NT_166519.1 Remark: in agreement with the wealth of genetic data available, transcript level analyses demonstrate that gabA (A. nidulans) is subject to carbon catabolite and nitrogen metabolite repression, omega-amino acid induction and regulation in response to ambient pH (being acid-expressed).; Title: strong similarity to GABA permease gabA -Aspergillus nidulans; See PMID 10320578; uncharacterized protein 2027769 4979323 An02g08340 Aspergillus niger uncharacterized protein XP_059600040.1 2025837 R 5061 CDS An02g08350 4979324 join(2028175..2028220,2028499..2029124,2029185..2030120) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein encoded by An16g00980 - Aspergillus niger; uncharacterized protein 2030120 4979324 An02g08350 Aspergillus niger uncharacterized protein XP_059600041.1 2028175 D 5061 CDS An02g08360 4979325 join(2030510..2030585,2030621..2030770,2030943..2030995) IV 1 NT_166519.1 hypothetical protein 2030995 4979325 An02g08360 Aspergillus niger hypothetical protein XP_059600042.1 2030510 D 5061 CDS An02g08370 4979326 join(2031611..2032521,2032588..2033158) IV 1 NT_166519.1 Catalytic activity: RCH2NH2 + H2O + O2 = RCHO + NH3 + H2O2.; Pathway: glycine, serine and threonine metabolism; arginine and proline metabolism; histidine metabolism; tyrosine metabolism; phenylalanine metabolism; tryptophan metabolism.; Remark: MAO-N has the C-terminal tripeptide Ala-Arg-Leu, which corresponds to the consensus targeting sequence found in many peroxisomal enzymes.; Title: strong similarity to monoamine oxidase N mao-N - Aspergillus niger; See PMID 7727530; See PMID 7770050; uncharacterized protein 2033158 4979326 An02g08370 Aspergillus niger uncharacterized protein XP_001399969.1 2031611 D 5061 CDS An02g08380 4979327 join(2038104..2042955,2043014..2043261) IV 1 NT_166519.1 Remark: alternative name is MSI2.; Remark: in S. cerevisiae the protein is a Gdp/GTP exchange factor required for growth at low temperatures. Under non-permissive conditions, more than 70% of the msi2 disruptants arrested at telophase as large budded cells with two nuclei divided completely and elongated spindles,indicating that the msi2 deletion is a cell division cycle mutation.; Title: strong similarity to guanine nucleotide-releasing factor Lte1 - Saccharomyces cerevisiae; See PMID 7941731; See PMID 7985422; uncharacterized protein 2043261 4979327 An02g08380 Aspergillus niger uncharacterized protein XP_059600043.1 2038104 D 5061 CDS An02g08390 4979328 join(2044107..2044299,2044414..2044922,2044986..2045390,2045460..2046929,2047070..2047128,2047289..2047404,2047448..2047455,2047500..2047622,2047800..2047943) IV 1 NT_166519.1 Remark: the S. Pombe protein is approximately only the half of the lentgh, but all other homologies show only that there is myosin heavy chain anaologies which is also very long.; Title: similarity to hypothetical protein SPAC25B8.08 - Schizosaccharomyces pombe; uncharacterized protein 2047943 4979328 An02g08390 Aspergillus niger uncharacterized protein XP_059600044.1 2044107 D 5061 CDS An02g08400 4979329 2048800..2050362 IV 1 NT_166519.1 Remark: all other homologies are to prolin rich proteins.; Title: similarity to hypothetical protein CAD70496.1 - Neurospora crassa; uncharacterized protein 2050362 4979329 An02g08400 Aspergillus niger uncharacterized protein XP_001399972.1 2048800 D 5061 CDS An02g08410 4979330 complement(join(2052180..2052560,2052620..2054698)) IV 1 NT_166519.1 Remark: in Drosophila the locus where RN-tre is found produces a number of transcripts that accumulate ubiquitously during early embryogenesis but more specifically in the central nervous system during later stages.; Similarity: similar sequences have been identified in Arabidopsis thaliana, Caenorhabditis elegans, Homo sapiens, Mus musculus and S. cerevisiae.; Title: strong similarity to tre oncogene-related protein RN-tre - Drosophila melanogaster; See PMID 9512660; uncharacterized protein 2054698 4979330 An02g08410 Aspergillus niger uncharacterized protein XP_001399973.3 2052180 R 5061 CDS An02g08420 4979331 complement(join(2057255..2057494,2057562..2057834,2057893..2058368,2058479..2058539,2058634..2058738)) IV 1 NT_166519.1 Remark: Aspergillus nidulans reproduces asexually via uninucleate, haploid spores, which are produced on morphologically differentiated aerial structures, called conidiophores. hymA is involved in budding processes, and is required for the formation of metulae and for their further differentiation.; Title: strong similarity to hypha-like metulae protein hymA - Aspergillus nidulans; See PMID 8969518; See PMID 9928930; uncharacterized protein 2058738 4979331 An02g08420 Aspergillus niger uncharacterized protein XP_001399974.1 2057255 R 5061 CDS An02g08430 4979332 join(2059349..2059586,2059720..2060133,2060194..2060431,2060497..2061247) IV 1 NT_166519.1 Remark: PRMT3, asymmetrically dimethylates arginine residues present both in the designed substrate GST-GAR and in substrate proteins present in hypomethylated extracts of a yeast rmt1 mutant that lacks type I arginine methyltransferase activity; PRMT3 is thus a functional type I protein arginine N-methyltransferase.; Remark: methylation is one of the many post-translational modifications that modulate protein function.; Title: strong similarity to protein arginine N-methyltransferase 3 PRMT3 - Rattus norvegicus; See PMID 9642256; uncharacterized protein 2061247 4979332 An02g08430 Aspergillus niger uncharacterized protein XP_001399975.1 2059349 D 5061 CDS An02g08440 4979333 complement(join(2061448..2062492,2062554..2062561)) IV 1 NT_166519.1 Remark: the Blastn match against entry EMBL:AF263922 (A. niger NsfA gene) arise from additional, not annotated DNA sequences next to the NsfA gene in this EMBL-entry.; Title: strong similarity to hypothetical protein CAD70331.1 - Neurospora crassa; uncharacterized protein 2062561 4979333 An02g08440 Aspergillus niger uncharacterized protein XP_001399976.1 2061448 R 5061 CDS An02g08445 84590393 join(2063043..2063164,2063222..2063309) IV 1 NT_166519.1 Remark: the similarity is restricted to the very N-terminus of the matching protein.; Title: weak similarity to essential protein #664 from patent WO200286090-A2 - Aspergillus fumigatus; uncharacterized protein 2063309 84590393 An02g08445 Aspergillus niger uncharacterized protein XP_059600045.1 2063043 D 5061 CDS An02g08450 4979335 join(2063422..2063742,2063793..2065658) IV 1 NT_166519.1 Gene-ID: nsfA; Remark: strong similarity to Sec18 S. cerevisiae. SEC18 gene function is required for secretory protein transport between the endoplasmic reticulum (ER) and the Golgi complex.; Remark: the differences in the sequence are caused by strain variations or sequencing errors.; Remark: there is no publication for the A. niger genproduct available.; secretory gene nsfA-Aspergillus niger 2065658 nsfA 4979335 nsfA Aspergillus niger secretory gene nsfA-Aspergillus niger XP_003188590.2 2063422 D 5061 CDS An02g08460 4979336 join(2066745..2067171,2067240..2067577) IV 1 NT_166519.1 Remark: most of the blastp matches are unspecific.; Title: weak similarity to hypothetical protein F17L21.7 - Arabidopsis thaliana; uncharacterized protein 2067577 4979336 An02g08460 Aspergillus niger uncharacterized protein XP_001399979.1 2066745 D 5061 CDS An02g08470 4979337 complement(join(2069869..2069950,2070157..2070309,2070428..2070735)) IV 1 NT_166519.1 Title: similarity to hypothetical protein YGL079w -Saccharomyces cerevisiae; uncharacterized protein 2070735 4979337 An02g08470 Aspergillus niger uncharacterized protein XP_001399980.1 2069869 R 5061 CDS An02g08480 84590394 complement(join(2074535..2074882,2074947..2074990,2075043..2075094)) IV 1 NT_166519.1 hypothetical protein 2075094 84590394 An02g08480 Aspergillus niger hypothetical protein XP_059600046.1 2074535 R 5061 CDS An02g08490 4979339 complement(join(2076378..2076665,2076722..2076835,2076900..2082215)) IV 1 NT_166519.1 Function: barA of E. coli could activate ompR by phosphorylation.; Function: over-expression of barA of E. coli suppresses a defect in ompC and ompF expression.; Similarity: barA of E. coli shows similarity to other prokaryotic sensory transduction histidine kinases.; Title: similarity to sensor-regulator protein barA -Escherichia coli; See PMID 1574005; See PMID 7957084; uncharacterized protein 2082215 4979339 An02g08490 Aspergillus niger uncharacterized protein XP_001399982.3 2076378 R 5061 CDS An02g08500 84590395 join(2083371..2083447,2083810..2083853,2083965..2084139,2084384..2084479,2084686..2085220) IV 1 NT_166519.1 hypothetical protein 2085220 84590395 An02g08500 Aspergillus niger hypothetical protein XP_059600047.1 2083371 D 5061 CDS An02g08510 4979341 join(2088980..2091591,2091643..2092830,2092886..2093375,2093428..2093908,2093957..2095974) IV 1 NT_166519.1 Title: similarity to sensor/regulator protein RpfA -Erwinia carotovora; uncharacterized protein 2095974 4979341 An02g08510 Aspergillus niger uncharacterized protein XP_059603417.1 2088980 D 5061 CDS An02g08520 4979342 complement(2096624..2097697) IV 1 NT_166519.1 Catalytic activity: allantoate + H(2)O = (-)-ureidoglycolate + urea.; Remark: also hydrolyses (+)-ureidoglycolate to glyoxylate and urea.; Title: strong similarity to allantoicase alc -Neurospora crassa; See PMID 2148685; uncharacterized protein 2097697 4979342 An02g08520 Aspergillus niger uncharacterized protein XP_001399985.1 2096624 R 5061 CDS An02g08530 4979343 complement(join(2098940..2098961,2099155..2099465)) IV 1 NT_166519.1 hypothetical protein 2099465 4979343 An02g08530 Aspergillus niger hypothetical protein XP_001399986.3 2098940 R 5061 CDS An02g08540 84590396 join(2104005..2104043,2104154..2104260,2104296..2104607,2104655..2104814,2104942..2105232) IV 1 NT_166519.1 Similarity: patentmatch against protein AC W12703 Geneseqprot.; Title: weak similarity to 2-5A-dependent RNase from patent WO9639806-A1 - Mus musculus; uncharacterized protein 2105232 84590396 An02g08540 Aspergillus niger uncharacterized protein XP_059603418.1 2104005 D 5061 CDS An02g08560 4979346 join(2106488..2107115,2107171..2107514) IV 1 NT_166519.1 Title: similarity to hypothetical dioxygenase SCOEDB - Streptomyces coelicolor; uncharacterized protein 2107514 4979346 An02g08560 Aspergillus niger uncharacterized protein XP_001399989.1 2106488 D 5061 CDS An02g08570 4979347 join(2110936..2110992,2111067..2111471,2111550..2112188) IV 1 NT_166519.1 Remark: the annotated ORF shows also strong similarity to the A. niger EST an_2771.; Title: strong similarity to isopenicillin N acyltransferase aAT - Aspergillus nidulans; See PMID 7847890; See PMID 2120195; See PMID 2166227; uncharacterized protein 2112188 4979347 An02g08570 Aspergillus niger uncharacterized protein XP_001399990.1 2110936 D 5061 CDS An02g08580 84590397 join(2113001..2113021,2113217..2113783) IV 1 NT_166519.1 Similarity: similarities correspond to multiple serine-repeats.; Title: weak similarity to hypothetical serine-rich repeat protein - Schizosaccharomyces pombe; uncharacterized protein 2113783 84590397 An02g08580 Aspergillus niger uncharacterized protein XP_059603419.1 2113001 D 5061 CDS An02g08590 4979349 join(2114461..2114593,2114643..2114699,2114754..2114869,2114904..2115398) IV 1 NT_166519.1 Function: after binding acetylcholine, the homolog from X. laevis achr responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.; Title: strong similarity to hypothetical cytochrom B561 related protein CAD70500.1 - Neurospora crassa; uncharacterized protein 2115398 4979349 An02g08590 Aspergillus niger uncharacterized protein XP_059603420.1 2114461 D 5061 CDS An02g08600 4979350 2115793..2117298 IV 1 NT_166519.1 Catalytic activity: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).; Remark: mature SerZMm homolog protein overexpressed in E. coli efficiently aminoacylated bacterial tRNA(Ser) in vitro.; Title: strong similarity to mitochondrial serine--tRNA ligase serS - Zea mays; localisation:mitochondrion; See PMID 9747857; uncharacterized protein 2117298 4979350 An02g08600 Aspergillus niger uncharacterized protein XP_001399993.1 2115793 D 5061 CDS An02g08610 4979351 complement(join(2118010..2119152,2119215..2119742)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein CAD21038.1 - Neurospora crassa; uncharacterized protein 2119742 4979351 An02g08610 Aspergillus niger uncharacterized protein XP_001399994.1 2118010 R 5061 CDS An02g08620 4979352 join(2121188..2121656,2121710..2121826,2121932..2122247,2122304..2123135) IV 1 NT_166519.1 Remark: disruption of the acr-2 gene in N. crassa lead to progenies that were hypersensitive to acriflavine.; Title: strong similarity to transcription factor involved in acriflavine resistance acr-2 - Neurospora crassa; uncharacterized protein 2123135 4979352 An02g08620 Aspergillus niger uncharacterized protein XP_059603421.1 2121188 D 5061 CDS An02g08630 4979353 complement(join(2124570..2124914,2124972..2126756)) IV 1 NT_166519.1 Title: strong similarity to phosphoinositide dependent protein kinase-1 PDK1 - Homo sapiens; uncharacterized protein 2126756 4979353 An02g08630 Aspergillus niger uncharacterized protein XP_001399996.3 2124570 R 5061 CDS An02g08640 4979354 join(2128900..2129634,2129715..2130036,2130134..2130567,2130623..2130766) IV 1 NT_166519.1 Similarity: similarities correspond to multiple serine-repeats.; Title: weak similarity to hypothetical membrane protein YMR317w - Saccharomyces cerevisiae; uncharacterized protein 2130766 4979354 An02g08640 Aspergillus niger uncharacterized protein XP_059603422.1 2128900 D 5061 CDS An02g08650 84590398 join(2132089..2132143,2132331..2132414,2132477..2132502,2132686..2132820,2132910..2133005) IV 1 NT_166519.1 Title: strong similarity to EST AN07D07 -Aspergillus niger; uncharacterized protein 2133005 84590398 An02g08650 Aspergillus niger uncharacterized protein XP_059603423.1 2132089 D 5061 CDS An02g08660 4979356 complement(join(2133188..2133775,2133838..2134263,2134315..2134665,2134747..2134827,2134899..2134968,2135074..2135090)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein H04M03.4 - Caenorhabditis elegans; uncharacterized protein 2135090 4979356 An02g08660 Aspergillus niger uncharacterized protein XP_001399999.3 2133188 R 5061 CDS An02g08670 4979357 join(2139415..2139545,2139605..2139672,2139740..2139745,2139804..2140021,2140072..2140479,2140542..2140910) IV 1 NT_166519.1 Title: strong similarity to hypothetical phosphate/phosphoenolpyruvate translocator protein At2g25520 - Arabidopsis thaliana; uncharacterized protein 2140910 4979357 An02g08670 Aspergillus niger uncharacterized protein XP_003188591.1 2139415 D 5061 CDS An02g08680 4979358 2142680..2143786 IV 1 NT_166519.1 Title: strong similarity to hypothetical protein CAD70306.1 - Neurospora crassa; uncharacterized protein 2143786 4979358 An02g08680 Aspergillus niger uncharacterized protein XP_001400001.1 2142680 D 5061 CDS An02g08685 84590399 2144122..2144298 IV 1 NT_166519.1 hypothetical protein 2144298 84590399 An02g08685 Aspergillus niger hypothetical protein XP_059603424.1 2144122 D 5061 CDS An02g08690 4979360 complement(join(2144616..2144753,2144828..2144957,2145041..2145179,2145244..2145360,2145422..2145499,2145565..2145580,2145635..2145896,2145995..2146268,2146303..2146503,2146570..2146654)) IV 1 NT_166519.1 Title: strong similarity to galactose permease Gal2 - Saccharomyces cerevisiae; See PMID 2666404; See PMID 2697639; uncharacterized protein 2146654 4979360 An02g08690 Aspergillus niger uncharacterized protein XP_059603425.1 2144616 R 5061 CDS An02g08700 4979361 complement(2147870..2150128) IV 1 NT_166519.1 Complex: human TFIIIB related factor hBRF is part of the TBP-containing complex 0. 38M-TFIIIB.; Function: the human 0. 38M-TFIIIB complex is required for transcription of the adenovirus type 2 VAI gene.; Title: strong similarity to TFIIIB related factor hBRF - Homo sapiens; See PMID 8943358; uncharacterized protein 2150128 4979361 An02g08700 Aspergillus niger uncharacterized protein XP_059603426.1 2147870 R 5061 CDS An02g08710 84590400 complement(2150917..2152917) IV 1 NT_166519.1 Remark: The transposable element Tan1 of Aspergillus niger var. awamori is a member of the Fot1 family.; Remark: This ORF has 31 stop codons.; Title: strong similarity to transposase Tan1 -Aspergillus niger [putative pseudogene]; putative pseudogene; See PMID 8625427; See PMID 9003286; uncharacterized protein 2152917 84590400 An02g08710 Aspergillus niger uncharacterized protein XP_059603427.1 2150917 R 5061 CDS An02g08720 4979363 2153875..2157651 IV 1 NT_166519.1 Title: strong similarity to copper resistance-associated P-type ATPase CRP1 - Candida albicans; See PMID 10737803; uncharacterized protein 2157651 4979363 An02g08720 Aspergillus niger uncharacterized protein XP_001400006.1 2153875 D 5061 CDS An02g08730 4979364 complement(join(2158115..2159197,2159247..2159653,2159703..2159872,2159931..2160022)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein SPCC4G3.05c - Schizosaccharomyces pombe; uncharacterized protein 2160022 4979364 An02g08730 Aspergillus niger uncharacterized protein XP_001400007.1 2158115 R 5061 CDS An02g08740 4979365 join(2160613..2160903,2160956..2161165,2161226..2161737,2161791..2162018,2162077..2162869) IV 1 NT_166519.1 hypothetical protein 2162869 4979365 An02g08740 Aspergillus niger hypothetical protein XP_001400008.1 2160613 D 5061 CDS An02g08750 4979366 complement(2163128..2164081) IV 1 NT_166519.1 Catalytic activity: the A. eutrophus UDPglucose 4-epimerase converts UDP-glucose to UDP-galactose.; Title: strong similarity to hypothetical UDP-glucose 4-epimerase - Alcaligenes eutrophus; See PMID 7851418; uncharacterized protein 2164081 4979366 An02g08750 Aspergillus niger uncharacterized protein XP_001400009.1 2163128 R 5061 CDS An02g08760 4979367 join(2165159..2165273,2165381..2165513,2165596..2166671,2166746..2167398) IV 1 NT_166519.1 Title: similarity to apoptosis associated protein #11 from patent WO200102550-A2 - Candida albicans; uncharacterized protein 2167398 4979367 An02g08760 Aspergillus niger uncharacterized protein XP_001400010.1 2165159 D 5061 CDS An02g08770 4979368 complement(2167514..2168557) IV 1 NT_166519.1 Title: weak similarity to hypothetical protein AAN36506.1 - Plasmodium falciparum; uncharacterized protein 2168557 4979368 An02g08770 Aspergillus niger uncharacterized protein XP_001400011.1 2167514 R 5061 CDS An02g08780 4979369 complement(2169087..2170490) IV 1 NT_166519.1 Title: similarity to hypothetical protein B7F18.110 - Neurospora crassa; uncharacterized protein 2170490 4979369 An02g08780 Aspergillus niger uncharacterized protein XP_001400012.1 2169087 R 5061 CDS An02g08790 4979370 join(2170759..2171529,2171587..2173054,2173114..2173166) IV 1 NT_166519.1 Title: similarity to hypothetical protein B7F18.120 - Neurospora crassa; uncharacterized protein 2173166 4979370 An02g08790 Aspergillus niger uncharacterized protein XP_059603428.1 2170759 D 5061 CDS An02g08800 4979371 2173904..2174917 IV 1 NT_166519.1 Title: similarity to hypothetical protein CIP1 -Candida sp.; uncharacterized protein 2174917 4979371 An02g08800 Aspergillus niger uncharacterized protein XP_001400014.1 2173904 D 5061 CDS An02g08810 4979372 join(2176461..2176543,2176851..2177259) IV 1 NT_166519.1 Similarity: just strong repetitive similarities.; hypothetical protein 2177259 4979372 An02g08810 Aspergillus niger hypothetical protein XP_059603429.1 2176461 D 5061 CDS An02g08820 4979373 complement(join(2178186..2178353,2178425..2178799,2178855..2179777,2179831..2180111,2180171..2180295,2180384..2180638)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein SPBC31F10.16 - Schizosaccharomyces pombe; uncharacterized protein 2180638 4979373 An02g08820 Aspergillus niger uncharacterized protein XP_059603430.1 2178186 R 5061 CDS An02g08830 4979374 join(2181126..2185408,2185505..2185685,2185738..2185893,2185950..2187386) IV 1 NT_166519.1 Title: similarity to hypothetical protein SPBC31F10.14c - Schizosaccharomyces pombe; uncharacterized protein 2187386 4979374 An02g08830 Aspergillus niger uncharacterized protein XP_059603431.1 2181126 D 5061 CDS An02g08840 4979375 complement(join(2187708..2188042,2188096..2188156,2188207..2188737,2188788..2188915,2188962..2189976,2190039..2190404)) IV 1 NT_166519.1 Title: similarity to rabkinesin-6 - Mus musculus; See PMID 9438855; uncharacterized protein 2190404 4979375 An02g08840 Aspergillus niger uncharacterized protein XP_059603432.1 2187708 R 5061 CDS An02g08845 4979376 join(2191135..2191237,2191358..2191526,2191579..2191899,2191993..2192240,2192487..2192563) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein CAD60765.1 - Podospora anserina; uncharacterized protein 2192563 4979376 An02g08845 Aspergillus niger uncharacterized protein XP_059603433.1 2191135 D 5061 CDS An02g08850 4979377 join(2192848..2192874,2192967..2193083,2193160..2193477) IV 1 NT_166519.1 Function: Ubc4 of S. cerevisiae is involved in heat shock response and turnover of short-lived proteins.; Function: Ubc4 of S. cerevisiae is one of several ubiquitin-conjugating enzymes that attach posttranslational ubiquitin to proteins.; Remark: Ubiquitin conjugating enzymes are involved in rapid and highly selective protein degradation.; Remark: Ubiquitin conjugating enzymes are involved in the regulation by degradation in many different cellular pathways.; Title: strong similarity to ubiquitin conjugating enzyme Ubc4 - Saccharomyces cerevisiae; See PMID 2154373; uncharacterized protein 2193477 4979377 An02g08850 Aspergillus niger uncharacterized protein XP_001400020.1 2192848 D 5061 CDS An02g08860 4979378 join(2194154..2194462,2194551..2194758,2194846..2194964,2195021..2195968) IV 1 NT_166519.1 Title: strong similarity to cytochrome P450 pisatin demethylase PDAT9 - Nectria haematococca; uncharacterized protein 2195968 4979378 An02g08860 Aspergillus niger uncharacterized protein XP_059603434.1 2194154 D 5061 CDS An02g08870 10098050 join(2198480..2200821,2200955..2201013,2201240..2201595,2201649..2202730,2202768..2202834) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein SPCC4G3.09c - Schizosaccharomyces pombe; uncharacterized protein 2202834 10098050 An02g08870 Aspergillus niger uncharacterized protein XP_059603435.1 2198480 D 5061 CDS An02g08880 4979380 complement(join(2203159..2204060,2204137..2204272,2204366..2204455)) IV 1 NT_166519.1 Title: similarity to hypothetical protein PFB0705w -Plasmodium falciparum; uncharacterized protein 2204455 4979380 An02g08880 Aspergillus niger uncharacterized protein XP_001400023.1 2203159 R 5061 CDS An02g08890 4979381 complement(join(2205181..2206357,2206404..2207083)) IV 1 NT_166519.1 hypothetical protein 2207083 4979381 An02g08890 Aspergillus niger hypothetical protein XP_001400024.1 2205181 R 5061 CDS An02g08900 4979382 complement(join(2207821..2209161,2209233..2209362,2209420..2209610)) IV 1 NT_166519.1 Title: strong similarity to protein precursor Bcs1 -Saccharomyces cerevisiae; uncharacterized protein 2209610 4979382 An02g08900 Aspergillus niger uncharacterized protein XP_001400025.3 2207821 R 5061 CDS An02g08910 4979383 join(2210022..2210161,2210224..2210268,2210326..2210964,2211022..2211400) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein SC5C7.08 - Streptomyces coelicolor; uncharacterized protein 2211400 4979383 An02g08910 Aspergillus niger uncharacterized protein XP_001400026.3 2210022 D 5061 CDS An02g08920 4979384 join(2213330..2213354,2213417..2213483,2213552..2213760,2213843..2214433,2214487..2215124,2215178..2215273) IV 1 NT_166519.1 Function: CCT3 is required for microtubule and actin function in vivo.; Title: strong similarity to TCP1-related protein Cct3 - Saccharomyces cerevisiae; See PMID 7916460; uncharacterized protein 2215273 4979384 An02g08920 Aspergillus niger uncharacterized protein XP_001400027.1 2213330 D 5061 CDS An02g08930 4979385 complement(2215453..2216049) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein FLJ13902 - Homo sapiens; uncharacterized protein 2216049 4979385 An02g08930 Aspergillus niger uncharacterized protein XP_001400028.1 2215453 R 5061 CDS An02g08940 4979386 join(2216752..2216808,2216876..2217006,2217054..2217165,2217228..2219781,2219841..2220214) IV 1 NT_166519.1 Title: similarity to hypothetical ubiquitin-conjugating enzyme At2g16920 - Arabidopsis thaliana; uncharacterized protein 2220214 4979386 An02g08940 Aspergillus niger uncharacterized protein XP_059603436.1 2216752 D 5061 CDS An02g08950 4979387 join(2221055..2221073,2221361..2221496,2221555..2221723,2221796..2221858,2221910..2222512) IV 1 NT_166519.1 Title: weak similarity to hypothetical protein B0041.7 - Caenorhabditis elegans; uncharacterized protein 2222512 4979387 An02g08950 Aspergillus niger uncharacterized protein XP_059603437.1 2221055 D 5061 CDS An02g08960 84590401 join(2223272..2223304,2223334..2223357,2223435..2223524) IV 1 NT_166519.1 Title: questionable ORF; uncharacterized protein 2223524 84590401 An02g08960 Aspergillus niger uncharacterized protein XP_059603438.1 2223272 D 5061 CDS An02g08970 4979389 complement(join(2224246..2224586,2224790..2225015,2225064..2225435,2225493..2226494)) IV 1 NT_166519.1 Remark: S. cerevisiae cells expressing Tpo1 become resistant to polyamine toxicity,the resistance was overcome by bafilomycin A1, an inhibitor of vacuolar H+-ATPase.; Remark: alternate name for S. cerevisiae Tpo1: YLL028w.; Similarity: the ORF encoded protein shows also similarity to a protein involved in cephalosporin C biosynthesis of patent JP09009966-A, but its function is not clearly enough described.; Title: similarity to polyamine transport protein Tpo1 - Saccharomyces cerevisiae; See PMID 9920864; uncharacterized protein 2226494 4979389 An02g08970 Aspergillus niger uncharacterized protein XP_001400032.3 2224246 R 5061 CDS An02g08980 4979390 join(2227012..2227255,2227293..2228440) IV 1 NT_166519.1 Cofactor: FAD.; Function: amadoriases are a novel class of FAD enzymes which catalyze the oxidative deglycation of glycated amino acids to yield corresponding amino acids,glucosone, and H(2)O(2).; Remark: alternate name for amadoriase II A. fumigatus: fructosyl amine:oxygen oxidoreductase.; Similarity: the ORF encoded protein shows also strong similarity to the amadoriase from Aspergillus terreus described in patent JP10033180-A.; Title: strong similarity to amadoriase II -Aspergillus fumigatus; See PMID 9139700; See PMID 10684633; uncharacterized protein 2228440 4979390 An02g08980 Aspergillus niger uncharacterized protein XP_059603439.1 2227012 D 5061 CDS An02g08990 4979391 join(2229267..2229647,2229710..2230310,2230366..2230742) IV 1 NT_166519.1 Remark: a splice site was detected upstream of the START codon.; Title: weak similarity to eukaryotic initiation factor 4B Eif4B - Triticum aestivum; See PMID 10600500; uncharacterized protein 2230742 4979391 An02g08990 Aspergillus niger uncharacterized protein XP_059603440.1 2229267 D 5061 CDS An02g09000 4979392 join(2235568..2236513,2236567..2237543) IV 1 NT_166519.1 Similarity: the similarities of the ORF encoded protein to all other proteins are mainly based on repetitive structures.; Title: weak similarity to dentin sialophosphoprotein DSPP - Homo sapiens; uncharacterized protein 2237543 4979392 An02g09000 Aspergillus niger uncharacterized protein XP_001400035.1 2235568 D 5061 CDS An02g09010 4979393 join(2240006..2240083,2240136..2240309,2240365..2242650) IV 1 NT_166519.1 Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: weak similarity to intestinal mucin MUC2 -Homo sapiens; uncharacterized protein 2242650 4979393 An02g09010 Aspergillus niger uncharacterized protein XP_001400036.1 2240006 D 5061 CDS An02g09020 4979394 complement(join(2244699..2245784,2245856..2246239)) IV 1 NT_166519.1 Complex: Sds3p (S. cerevisiae) is an integral subunit of the high molecular weight Rpd3p/Sin3p containing yeast histone deacetylase complex (transcriptional repression).; Function: the S. cerevisae Sds3 protein is involved in transcriptional silencing at the HMR locus and telomeres.; Remark: alternate name for S. cerevisiae Sds3: YIL084c.; Similarity: the ORF encoded protein shows strong similarity to the hypothetical protein B2O8. 340 from Neurospora crassa, which is related to nif-specific regulatory protein from Rhizobium leguminosarum,PIR:S06965.; Title: similarity to component of the yeast histone deacetylase complex Sds3 - Saccharomyces cerevisiae; nucleus; See PMID 8978024; See PMID 10655212; See PMID 11024051; uncharacterized protein 2246239 4979394 An02g09020 Aspergillus niger uncharacterized protein XP_001400037.3 2244699 R 5061 CDS An02g09030 4979395 complement(join(2247204..2247672,2247738..2248260,2248341..2249115)) IV 1 NT_166519.1 Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; hypothetical protein 2249115 4979395 An02g09030 Aspergillus niger hypothetical protein XP_001400038.3 2247204 R 5061 CDS An02g09033 84590402 complement(join(2249396..2249754,2249849..2250083)) IV 1 NT_166519.1 hypothetical protein 2250083 84590402 An02g09033 Aspergillus niger hypothetical protein XP_059603441.1 2249396 R 5061 CDS An02g09040 4979397 complement(join(2255618..2256401,2256470..2256600)) IV 1 NT_166519.1 Title: strong similarity to EST g7c08a1.r1 -Aspergillus nidulans; uncharacterized protein 2256600 4979397 An02g09040 Aspergillus niger uncharacterized protein XP_001400040.1 2255618 R 5061 CDS An02g09050 4979398 join(2259018..2259165,2259228..2259439,2259552..2260670) IV 1 NT_166519.1 Similarity: the ORF encoded protein and Gel3 from Aspergillus fumigatus belong to the fungal Gas1 protein family.; Title: strong similarity to glycosylphosphatidylinositol-anchored beta(1-3)glucanosyltransferase gel3 - Aspergillus fumigatus; plasma membrane; See PMID 10769178; uncharacterized protein 2260670 4979398 An02g09050 Aspergillus niger uncharacterized protein XP_001400041.1 2259018 D 5061 CDS An02g09060 4979399 complement(2261447..2263621) IV 1 NT_166519.1 Similarity: the ORF encoded protein shows similarity/weak similarity to the many known and hypothetical protein kinases.; Title: similarity to disease associated protein kinase DAPK-3 from patent WO9858052-A2 - Homo sapiens; uncharacterized protein 2263621 4979399 An02g09060 Aspergillus niger uncharacterized protein XP_001400042.1 2261447 R 5061 CDS An02g09070 4979400 complement(join(2266741..2266938,2267197..2267664)) IV 1 NT_166519.1 Title: weak similarity to precursor of alpha/beta-gliadin - Triticum aestivum; uncharacterized protein 2267664 4979400 An02g09070 Aspergillus niger uncharacterized protein XP_001400043.1 2266741 R 5061 CDS An02g09080 4979401 complement(join(2269043..2272607,2272735..2272787,2272999..2273005,2273038..2273072,2273119..2273274)) IV 1 NT_166519.1 Similarity: the similarities of the ORF encoded protein to all other proteins are mainly based on repetitive structures.; Title: weak similarity to dentin sialophosphoprotein DSPP - Homo sapiens; uncharacterized protein 2273274 4979401 An02g09080 Aspergillus niger uncharacterized protein XP_001400044.3 2269043 R 5061 CDS An02g09090 4979402 2273929..2275140 IV 1 NT_166519.1 Catalytic activity: alpha-D-glucose <=> beta-D-glucose.; Remark: alternate names for mutarotase enzyme: mutarotase or aldose mutarotase.; Similarity: the ORF encoded protein shows also strong similarity to the characterized aldose 1-epimerase mro from Acinetobacter calcoaceticus (Pubmed 3012466).; Title: strong similarity to mutarotase enzyme from patent JP07039380-A - Sus scrofa; uncharacterized protein 2275140 4979402 An02g09090 Aspergillus niger uncharacterized protein XP_001400045.3 2273929 D 5061 CDS An02g09100 4979403 complement(2275547..2277256) IV 1 NT_166519.1 Function: the Act2 protein from S. cerevisiae plays an important role in nuclear pore complex (NPC) structure and function.; Similarity: the ORF encoded protein shows strong similarity to the actin-related protein RO7, required for nuclear localization and proper localization of cytoplasmic dynein and dynactin in Neurospora crassa (still unpublished).; Title: similarity to actin-like protein Act2 -Saccharomyces cerevisiae; See PMID 9218799; See PMID 1729653; uncharacterized protein 2277256 4979403 An02g09100 Aspergillus niger uncharacterized protein XP_001400046.1 2275547 R 5061 CDS An02g09120 4979404 complement(2277558..2281970) IV 1 NT_166519.1 Remark: the ORF belongs to a retrotransposon-like sequence found also in other contigs.; Remark: the tobacco retrotransposon Tto1 is one of the few active retrotransposons of plants.; Title: strong similarity to hypothetical retrotransposon Tto1 - Nicotiana tabacum; See PMID 8624443; uncharacterized protein 2281970 4979404 An02g09120 Aspergillus niger uncharacterized protein XP_001400047.1 2277558 R 5061 CDS An02g09150 4979405 join(2282647..2282660,2282791..2285357,2285409..2285446) IV 1 NT_166519.1 Remark: the ORF encoded protein partly contains repetitive structures.; Title: similarity to structure specific nuclease 5 from patent WO9823774-A - Unclassified organism; uncharacterized protein 2285446 4979405 An02g09150 Aspergillus niger uncharacterized protein XP_001400048.3 2282647 D 5061 CDS An02g09160 4979406 complement(2286063..2287217) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein YOR311c - Saccharomyces cerevisiae; uncharacterized protein 2287217 4979406 An02g09160 Aspergillus niger uncharacterized protein XP_001400049.1 2286063 R 5061 CDS An02g09170 4979407 join(2287846..2288184,2288306..2288709,2288765..2289890) IV 1 NT_166519.1 Function: Spb4p from S. cerevisiae (an essential putative RNA helicase) is required for a late step in the assembly of 60S ribosomal subunits.; Remark: alternate name for S. cerevisiae Spb4: YFL002C.; Title: strong similarity to ATP dependent RNA helicase Spb4 - Saccharomyces cerevisiae; nucleus; See PMID 8774901; See PMID 9769101; uncharacterized protein 2289890 4979407 An02g09170 Aspergillus niger uncharacterized protein XP_059603442.1 2287846 D 5061 CDS An02g09180 4979408 complement(join(2290523..2291066,2291129..2292029,2292080..2293955)) IV 1 NT_166519.1 Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: the similarities of the ORF encoded protein to MUC1 from S. cerevisiae and the other proteins are mainly based on repetitive stretches in the sequence.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942; uncharacterized protein 2293955 4979408 An02g09180 Aspergillus niger uncharacterized protein XP_059603443.1 2290523 R 5061 CDS An02g09190 4979409 complement(join(2295068..2295331,2295389..2295921,2295992..2296037)) IV 1 NT_166519.1 Remark: alternate name for S. cerevisiae MRPS28: YDR337w.; Title: strong similarity to mitochondrial ribosomal protein of the small subunit S15 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 2263452; mitochondrial 37S ribosomal protein uS15m 2296037 4979409 An02g09190 Aspergillus niger mitochondrial 37S ribosomal protein uS15m XP_059603444.1 2295068 R 5061 CDS An02g09200 4979410 join(2296386..2296555,2296627..2297353) IV 1 NT_166519.1 Function: the S. cerevisiae Yst1 protein binds DNA. it is required for the assembly and/or stability of the 40S ribosomal subunit.; Remark: the C. albicans CaYst1 protein complements the lethality of a yst1 null mutation in S. cerevisiae.; Similarity: the ORF encoded protein shows also strong similarity to the S. cervisiae Yst1 protein; Title: strong similarity to translational factor CaYST1 - Candida albicans; See PMID 9579059; 40S ribosomal protein uS2 2297353 4979410 An02g09200 Aspergillus niger 40S ribosomal protein uS2 XP_001400053.1 2296386 D 5061 CDS An02g09210 4979411 complement(join(2298086..2298247,2298327..2298446,2298501..2298723,2298835..2298923)) IV 1 NT_166519.1 Remark: alternate name for S. cerevisiae Rho2: YNL090W.; Title: similarity to GTP-binding protein Rho2 -Saccharomyces cerevisiae; See PMID 9038344; See PMID 9405296; See PMID 1441750; uncharacterized protein 2298923 4979411 An02g09210 Aspergillus niger uncharacterized protein XP_059603445.1 2298086 R 5061 CDS An02g09220 4979412 join(2299570..2300012,2300070..2300179,2300294..2300635,2300738..2301396) IV 1 NT_166519.1 Catalytic activity: tRNA uridine <=> tRNA pseudouridine.; Function: the Deg1 product from S. cerevisiae is responsible for the formation of pseudouridine at position 38 and 39 in the anticodon stem and loop of tRNAs.; Localization: Deg1p (S. cer.) localizes both in the nucleus and in the cytoplasm.; Remark: alternate names for S. cerevisiae Deg1: Pus3, YFL001W.; Title: strong similarity to pseudouridine synthase Deg1 - Saccharomyces cerevisiae; nucleus; See PMID 9430663; uncharacterized protein 2301396 4979412 An02g09220 Aspergillus niger uncharacterized protein XP_059603446.1 2299570 D 5061 CDS An02g09230 4979413 complement(join(2301495..2301572,2301636..2301838,2301904..2302237)) IV 1 NT_166519.1 Title: similarity to glycosylphosphatidylinositol anchor class H biosynthesis protein GPI-H - Homo sapiens; See PMID 8054538; See PMID 8407896; uncharacterized protein 2302237 4979413 An02g09230 Aspergillus niger uncharacterized protein XP_001400056.1 2301495 R 5061 CDS An02g09240 4979414 join(2303968..2304885,2304938..2305261,2305313..2305369) IV 1 NT_166519.1 Catalytic activity: ATP + D-ribose 5-phosphate <=> AMP + 5-phospho-alpha-D-ribose 1-diphosphate.; Remark: alternate name for S. cerevisiae Prs5: YOL061W.; Title: strong similarity to ribose-phosphate pyrophosphokinase Prs5 - Saccharomyces cerevisiae; See PMID 9829955; uncharacterized protein 2305369 4979414 An02g09240 Aspergillus niger uncharacterized protein XP_001400057.1 2303968 D 5061 CDS An02g09250 4979415 complement(join(2306203..2306286,2306342..2307225,2307291..2307379,2307446..2307477)) IV 1 NT_166519.1 Function: the vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. The active enzyme consists of a catalytic V1 domain attached to an integral membrane V0 proton pore complex. The Vma6 subunit from S. cerevisiae is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector.; Title: strong similarity to subunit of the vacuolar ATPase Vma6 - Saccharomyces cerevisiae; vacuole; See PMID 8509410; uncharacterized protein 2307477 4979415 An02g09250 Aspergillus niger uncharacterized protein XP_001400058.1 2306203 R 5061 CDS An02g09260 4979416 join(2307814..2307938,2308065..2308225,2308294..2309750) IV 1 NT_166519.1 Complex: the S. cerevisiae Nop5 protein interacts with Nop1.; Function: S. cerevisiae Nop5 is required for pre-18S rRNA processing.; Remark: alternate names for S. cerevisiae Nop5: Nop58 or YOR310C.; Title: strong similarity to nucleolar protein Nop5 -Saccharomyces cerevisiae; nucleus; See PMID 9632712; uncharacterized protein 2309750 4979416 An02g09260 Aspergillus niger uncharacterized protein XP_001400059.1 2307814 D 5061 CDS An02g09270 4979417 complement(join(2310631..2310738,2310809..2312353)) IV 1 NT_166519.1 Catalytic activity: Cellobiose + O(2) <=> cellobiono-1,5-lactone + H(2)O(2).; Cofactor: Flavoprotein; Heme.; Function: the cellobiose dehydrogenase (oxidase) (CBDH) is secreted by the soft-rot thermophilic fungus Humicola insolens during growth on cellulose.; Remark: alternate EC 1. 1. 99. 18.; Title: strong similarity to cellobiose dehydrogenase CBDH - Humicola insolens; extracellular/secretion proteins; See PMID 9461557; See PMID 9920875; uncharacterized protein 2312353 4979417 An02g09270 Aspergillus niger uncharacterized protein XP_001400060.1 2310631 R 5061 CDS An02g09280 4979418 join(2313743..2314155,2314241..2314490,2314521..2314673,2314878..2315426) IV 1 NT_166519.1 Similarity: the similarities of the ORF encoded protein to RPGR from B. taurus and to other proteins are only based on repetitive structures.; Title: similarity to retinitis pigmentosa GTPase regulator RPGR - Bos taurus; See PMID 10932196; uncharacterized protein 2315426 4979418 An02g09280 Aspergillus niger uncharacterized protein XP_059603447.1 2313743 D 5061 CDS An02g09290 4979419 complement(join(2316286..2317926,2317992..2318177)) IV 1 NT_166519.1 hypothetical protein 2318177 4979419 An02g09290 Aspergillus niger hypothetical protein XP_001400062.1 2316286 R 5061 CDS An02g09300 4979420 complement(2319602..2320648) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein CAD21172.1 - Neurospora crassa; uncharacterized protein 2320648 4979420 An02g09300 Aspergillus niger uncharacterized protein XP_001400063.1 2319602 R 5061 CDS An02g09310 4979421 complement(join(2321227..2321457,2321508..2322000,2322060..2322177,2322249..2322444)) IV 1 NT_166519.1 Remark: alternate names for the human stomatin protein: EPB72,BND7 or erythrocyte band 7 integral membrane protein.; Remark: defects in EPB72 in red blood cells of patients with hereditary stomatocytosis or cryohydrocytosis results in an increased Na+/K+-permeability and hence to a disorder of cell volume control.; Similarity: the ORF encoded protein shows also strong similarity to the human protein described in patent WO9925825-A2.; Title: strong similarity to erythrocyte membrane protein stomatin - Homo sapiens; See PMID 7592848; See PMID 8825639; See PMID 1547348; uncharacterized protein 2322444 4979421 An02g09310 Aspergillus niger uncharacterized protein XP_001400064.1 2321227 R 5061 CDS An02g09330 4979423 join(<2326496..2327001,2327064..2327688) IV 1 NT_166519.1 Remark: N-terminally truncated ORF due to the end of contig.; Title: weak similarity to S-phase kinase associated protein p45Skp2 from patent WO9711176-A2 - Homo sapiens [truncated ORF]; uncharacterized protein 2327688 4979423 An02g09330 Aspergillus niger uncharacterized protein XP_001400065.3 2326496 D 5061 CDS An02g09340 4979424 2328182..2329342 IV 1 NT_166519.1 Similarity: the ORF encoded protein shows also weak similarity chitinase ChiA from Emericella nidulans (Pubmed 9501518).; Title: weak similarity to TRK2 protein fragment from patent WO9909151-A2 - Lycopersicon esculentum; uncharacterized protein 2329342 4979424 An02g09340 Aspergillus niger uncharacterized protein XP_001400066.1 2328182 D 5061 CDS An02g09350 4979425 complement(join(2329580..2330278,2330341..2330857,2330928..2331557,2331622..2331968)) IV 1 NT_166519.1 Remark: the cDNA of the sulfate transport protein 2 (shst2) from Stylosanthes hamata has been isolated by complementation of a yeast mutant.; Title: strong similarity to sulfate transport protein shst2 - Stylosanthes hamata; See PMID 7568135; uncharacterized protein 2331968 4979425 An02g09350 Aspergillus niger uncharacterized protein XP_001400067.1 2329580 R 5061 CDS An02g09360 84590403 complement(join(2333182..2333577,2333657..2333692)) IV 1 NT_166519.1 hypothetical protein 2333692 84590403 An02g09360 Aspergillus niger hypothetical protein XP_059600048.1 2333182 R 5061 CDS An02g09370 4979427 join(<2334472..2334680,2334737..2335214) IV 1 NT_166519.1 Complex: the human eIF2 translation initiation factor is a heterotrimer composed of an alpha, a beta, and a gamma chain.; Function: the human eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40s ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with gIF by way of a reaction catalyzed by eIF-2b.; Remark: N-terminally truncated ORF due to the end of contig.; Title: similarity to translation initiation factor eIF-2 alpha chain EIF2A - Homo sapiens [truncated ORF]; cytoplasm; See PMID 1748310; See PMID 2948954; uncharacterized protein 2335214 4979427 An02g09370 Aspergillus niger uncharacterized protein XP_001400069.3 2334472 D 5061 CDS An02g09380 84590404 join(2335275..2335359,2335528..2335634,2335734..2335841) IV 1 NT_166519.1 Title: questionable ORF; uncharacterized protein 2335841 84590404 An02g09380 Aspergillus niger uncharacterized protein XP_059603448.1 2335275 D 5061 CDS An02g09390 4979429 join(2336001..2336076,2336136..2336463,2336520..2337454,2337510..2337650,2337700..2338133) IV 1 NT_166519.1 Function: the murine Trp6 protein is a nonselective capacitative calcium entry channel subunit. It mediates calcium entry stimulated by a G-protein coupled receptor but not by intracellular calcium store depletion. It becomes activated by diacylglycerol (DAG) in a membrane-delimited fashion independently of protein kinase C. It is permeable for calcium, cesium, sodium, potassium and magnesium.; Remark: TREMBL:SCYOR089C_2 is not S. cerevisiae YOR089c/Vps21. It is identical to a truncated YOR088c protein.; Similarity: only the C-terminal part of the ORF encoded protein shows strong similarity to the S. cerevisiae hypothetical protein YOR088c. The N-terminal part of the ORF encoded protein is similar to the complete peptide sequence of the hypothetical protein YOR087w from S. cerevisiae. The ORF encoded protein can not be divided into two separate ORFs.; Similarity: the ORF DNA sequence shows strong similarity the EST an_1965 from Aspergillus niger.; Title: similarity to capacitative calcium entry channel Trp6 - Mus musculus; plasma membrane; See PMID 9368034; uncharacterized protein 2338133 4979429 An02g09390 Aspergillus niger uncharacterized protein XP_059603449.1 2336001 D 5061 CDS An02g09420 4979432 complement(join(2339657..2339849,2339885..2340051,2340109..2340219,2340276..2340593,2340645..2341451)) IV 1 NT_166519.1 Function: TRI4 from F. sporotrichioides catalyzes the first oxygenation step in the trichothecene pathway and participates in apotrichodiol biosynthesis.; Remark: Trichothecenes are sesquiterpenoid toxins that act by inhibiting protein biosynthesis.; Remark: alternate name for Fusarium sporotrichioides TRI4: CYP58.; Similarity: TRI4 (F. s.) belongs to the cytochrome p450 family.; Title: strong similarity to cytochrome P450 trichodiene oxygenase TRI4 - Fusarium sporotrichioides; See PMID 7651333; uncharacterized protein 2341451 4979432 An02g09420 Aspergillus niger uncharacterized protein XP_059603450.1 2339657 R 5061 CDS An02g09430 4979433 join(2342236..2343345,2343398..2343521,2343573..2343685,2343733..2344183,2344251..2344697,2344749..2348239,2348294..2348634,2348692..2349163,2349219..>2350059) IV 1 NT_166519.1 Remark: FUM5 from Gibberella fujikuroi is a PKS gene required for fumonisin biosynthesis.; Remark: Fumonisins are toxins associated with several mycotoxicoses and are produced by the maize pathogen Gibberella fujikuroi mating population A (MP-A).; Remark: a putative frameshift results in an premature STOP codon.; Title: strong similarity to polyketide synthase FUM5 - Gibberella moniliformis [putative frameshift]; putative frameshift; See PMID 10413619; See PMID 11238987; uncharacterized protein 2350059 4979433 An02g09430 Aspergillus niger uncharacterized protein XP_059603451.1 2342236 D 5061 CDS An02g09440 4979434 complement(join(2350690..2351147,2351218..2352781)) IV 1 NT_166519.1 Remark: ankyrin repeats are believed to mediate protein-protein interactions.; Title: similarity to ankyrin Ank2 - Drosophila melanogaster; See PMID 7937942; uncharacterized protein 2352781 4979434 An02g09440 Aspergillus niger uncharacterized protein XP_059603452.1 2350690 R 5061 CDS An02g09450 84590405 join(2353322..2353411,2353489..2353587,2353806..2353874,2353953..2354033) IV 1 NT_166519.1 hypothetical protein 2354033 84590405 An02g09450 Aspergillus niger hypothetical protein XP_059603453.1 2353322 D 5061 CDS An02g09460 4979436 complement(join(2354370..2355000,2355069..2355288,2355343..2355717,2355777..2356270,2356334..2356356,2356435..2356719)) IV 1 NT_166519.1 Complex: S. cerevisiae Pep7 (Vac1) genetically and physically interacts with the activated, GTP-bound form of Vps21, a Rab GTPase that functions in Golgi-to-endosome transport, and with Vps45.; Function: S. cerevisiae Pep7 is required for the transport of the Golgi-precursors of the soluble hydrolases carboxypeptidase Y, proteinase A, and proteinase B to the endosome. Pep7 functions in a vesicle consumption step in vesicle-mediated transport of soluble hydrolases to the endosome.; Remark: alternate names for S. cerevisiae Pep7: Vac1, Vpl21, Vps19, Vpt19 or YDR323C.; Title: strong similarity to vacuolar segregation protein Pep7 - Saccharomyces cerevisiae; See PMID 9168472; See PMID 10021387; uncharacterized protein 2356719 4979436 An02g09460 Aspergillus niger uncharacterized protein XP_001400076.1 2354370 R 5061 CDS An02g09470 4979437 complement(join(2357268..2357697,2357756..2357892,2357946..2358379,2358419..>2359448)) IV 1 NT_166519.1 Function: Spf1 (Cod1) was discouvered to be involved in the control of HMG-CoA reductase degradation. spf1 mutants show resistance to the killer toxin SMKT. A functional characterization about its P-type ATPase function is not published yet.; Remark: N-terminally truncated ORF due to the end of contig.; Remark: alternate name for S. cerevisiae Spf1: Cod1 or YEL031W.; Similarity: S. cerevisiae Spf1 and the ORF encoded protein belong to the cation transport ATPases family (E1-E2 ATPases); subfamily V.; Title: strong similarity to hypothetical Ca2+-transporting ATPase Spf1 - Saccharomyces cerevisiae [truncated ORF]; plasma membrane; See PMID 10361284; See PMID 10704442; uncharacterized protein 2359448 4979437 An02g09470 Aspergillus niger uncharacterized protein XP_059603454.1 2357268 R 5061 CDS An02g09480 84590406 complement(<2359550..2361028) IV 1 NT_166519.1 Function: Spf1 (Cod1) was discouvered to be involved in the control of HMG-CoA reductase degradation. spf1 mutants show resistance to the killer toxin SMKT. A functional characterization about its P-type ATPase function is not published yet.; Remark: C-terminally truncated ORF due to the end of contig.; Remark: alternate name for S. cerevisiae Spf1: Cod1 or YEL031W.; Similarity: S. cerevisiae Spf1 and the ORF encoded protein belong to the cation transport ATPases family (E1-E2 ATPases); subfamily V.; Title: strong similarity to hypothetical Ca2+-transporting ATPase Spf1 - Saccharomyces cerevisiae [truncated ORF]; plasma membrane; See PMID 10361284; See PMID 10704442; uncharacterized protein 2361028 84590406 An02g09480 Aspergillus niger uncharacterized protein XP_059600049.1 2359550 R 5061 CDS An02g09490 84590407 complement(join(2361087..2361213,2361293..2361385,2361499..2361572,2361617..2361709,2361755..2361769)) IV 1 NT_166519.1 hypothetical protein 2361769 84590407 An02g09490 Aspergillus niger hypothetical protein XP_059600050.1 2361087 R 5061 CDS An02g09500 4979440 complement(join(2361939..2362324,2362381..2362445,2362503..2363038,2363102..2363254)) IV 1 NT_166519.1 Function: Pth11 from M. grisea is involved in surface dependent signal transduction during plant infection. Pth11 can activate appressorium differentiation in response to inductive surface cues and repress differentiation on poorly inductive surfaces.; Remark: the filamentous ascomycete Magnaporthe grisea is the blast pathogen of many grass species,including rice.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529; uncharacterized protein 2363254 4979440 An02g09500 Aspergillus niger uncharacterized protein XP_059600051.1 2361939 R 5061 CDS An02g09510 84590408 complement(join(2363448..2363595,2363761..2363912,2364013..2364114,2364359..2364424,2364506..2364595,2364696..2364820,2364953..2365217)) IV 1 NT_166519.1 hypothetical protein 2365217 84590408 An02g09510 Aspergillus niger hypothetical protein XP_059600052.1 2363448 R 5061 CDS An02g09520 84590409 complement(join(2365480..2365587,2365687..2365694,2365841..2365871,2366082..2366132)) IV 1 NT_166519.1 hypothetical protein 2366132 84590409 An02g09520 Aspergillus niger hypothetical protein XP_059600053.1 2365480 R 5061 CDS An02g09530 4979443 complement(join(2368427..2368494,2368727..2368889,2368927..2369291,2369428..2369495,2369555..2369697,2369744..2369962,2370032..2370136,2370190..2370387)) IV 1 NT_166519.1 Function: Pth11 from M. grisea is involved in surface dependent signal transduction during plant infection. Pth11 can activate appressorium differentiation in response to inductive surface cues and repress differentiation on poorly inductive surfaces.; Remark: the filamentous ascomycete Magnaporthe grisea is the blast pathogen of many grass species,including rice.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529; uncharacterized protein 2370387 4979443 An02g09530 Aspergillus niger uncharacterized protein XP_059600054.1 2368427 R 5061 CDS An02g09540 4979444 join(2371071..2371190,2371255..2371439,2371507..2371586,2371653..2371663,2371735..2372104,2372168..2372952) IV 1 NT_166519.1 Function: Hnm1 from S. cerevisiae is responsible for the yeast choline import. A mutant displays a phenotype only when the internal choline biosynthesis is destroyed (cho1-mutants).; Remark: alternate names for S. cerevisiae Hnm1: Ctr1, Ctr or YGL077C.; Title: strong similarity to choline permease Hnm1 -Saccharomyces cerevisiae; See PMID 1878995; uncharacterized protein 2372952 4979444 An02g09540 Aspergillus niger uncharacterized protein XP_001400084.1 2371071 D 5061 CDS An02g09550 4979445 complement(join(2373355..2373649,2373764..2373882,2373943..2374001,2374063..2374189)) IV 1 NT_166519.1 Function: disruption of het-c2 gene from Podospora anserina drastically impairs ascospore production in homozygous crosses, and some mutants exhibit abnormal branching of apical hyphae. the protein encoded by het-c2 is essential in the biology of the fungus and may be involved in cell-wall biosynthesis.; Similarity: the ORF encoded protein and the het-c2 protein from Podospora anserina are also similar to the pig glycolipid transfer protein, GTLP.; Title: strong similarity to protein het-c2 -Podospora anserina; See PMID 8016091; uncharacterized protein 2374189 4979445 An02g09550 Aspergillus niger uncharacterized protein XP_001400085.1 2373355 R 5061 CDS An02g09560 4979446 complement(join(2375032..2375449,2375508..2376142)) IV 1 NT_166519.1 Similarity: the ORF encoded protein shows strongest similarity to the unpublished human protein LRP16.; Title: strong similarity to protein regulating gene expression PRGE-6 from patent WO9964596-A2 - Homo sapiens; nucleus; uncharacterized protein 2376142 4979446 An02g09560 Aspergillus niger uncharacterized protein XP_001400086.1 2375032 R 5061 CDS An02g09570 84590410 join(2380463..2380527,2380664..2380844,2380938..2381089,2381152..2381260) IV 1 NT_166519.1 hypothetical protein 2381260 84590410 An02g09570 Aspergillus niger hypothetical protein XP_059600055.1 2380463 D 5061 CDS An02g09580 84590411 complement(join(2381360..2381499,2381566..2381788,2381853..2381945,2382263..2382298)) IV 1 NT_166519.1 hypothetical protein 2382298 84590411 An02g09580 Aspergillus niger hypothetical protein XP_059600056.1 2381360 R 5061 CDS An02g09600 84590412 complement(join(2383660..2383712,2383851..2384003,2384099..2384241,2384464..2384504)) IV 1 NT_166519.1 hypothetical protein 2384504 84590412 An02g09600 Aspergillus niger hypothetical protein XP_059600057.1 2383660 R 5061 CDS An02g09610 4979450 complement(join(2385298..2385506,2385677..2386010,2386103..2387036,2387123..2387154)) IV 1 NT_166519.1 Protein sequence is in conflict with the conceptual translation; Function: N. crassa WC-1 is a transcription factor involved in light regulation. It binds and affects blue light regulation of the AL-3 gene.; Similarity: the ORF encoded protein shows also exclusively very strong similarity to the E. nidulans NsdD gene product.; Similarity: the ORF encoded protein, WC-1 from N. crassa and NsdD from E. nidulans belong to the GATA-type transcription factor family.; Title: similarity to zinc-finger transcription factor WC-1 - Neurospora crassa; nucleus; putative frameshift; See PMID 9009271; uncharacterized protein 2387154 4979450 An02g09610 Aspergillus niger uncharacterized protein XP_001400090.3 2385298 R 5061 CDS An02g09620 84590413 complement(join(2388612..2388757,2388823..2389017,2389121..2389292,2389512..2389661)) IV 1 NT_166519.1 hypothetical protein 2389661 84590413 An02g09620 Aspergillus niger hypothetical protein XP_059600058.1 2388612 R 5061 CDS An02g09630 84590414 complement(join(2390911..2391065,2391265..2391415)) IV 1 NT_166519.1 hypothetical protein 2391415 84590414 An02g09630 Aspergillus niger hypothetical protein XP_059600059.1 2390911 R 5061 CDS An02g09640 84590415 complement(join(2393174..2393273,2393559..2393680,2394045..2394166,2394237..2394384,2394426..2394478,2394681..2394854,2394893..2394938,2395027..2395082,2395137..2395158)) IV 1 NT_166519.1 hypothetical protein 2395158 84590415 An02g09640 Aspergillus niger hypothetical protein XP_059600060.1 2393174 R 5061 CDS An02g09650 84590416 join(2395210..2395535,2395739..2395943) IV 1 NT_166519.1 hypothetical protein 2395943 84590416 An02g09650 Aspergillus niger hypothetical protein XP_059600061.1 2395210 D 5061 CDS An02g09660 84590417 complement(join(2396465..2396689,2396773..2396836,2397110..2397250,2397357..2397413,2397643..2397763,2397820..2397887,2398055..2398188)) IV 1 NT_166519.1 hypothetical protein 2398188 84590417 An02g09660 Aspergillus niger hypothetical protein XP_059600062.1 2396465 R 5061 CDS An02g09670 84590418 join(2398246..2398299,2398925..2399133,2399189..2399237,2399311..2399514) IV 1 NT_166519.1 hypothetical protein 2399514 84590418 An02g09670 Aspergillus niger hypothetical protein XP_059600063.1 2398246 D 5061 CDS An02g09680 84590419 complement(join(2402162..2402296,2402379..2402534,2402602..2402690,2402706..2402955)) IV 1 NT_166519.1 hypothetical protein 2402955 84590419 An02g09680 Aspergillus niger hypothetical protein XP_059600064.1 2402162 R 5061 CDS An02g09690 4979458 complement(join(2403836..2404434,2404505..2405125,2405182..2405368,2405455..2405733)) IV 1 NT_166519.1 Catalytic activity: triacylglycerol + H2O = diacylglycerol + a carboxylate; diacylglycerol + H2O = monoacylglycerol + a carboxylate.; Pathway: glycerolipid metabolism.; Remark: TFL I is a trimer enzyme.; Similarity: belongs to the carboxylesterases type-B family.; Title: strong similarity to lipase I precursor TFLI - Geotrichum fermentans; See PMID 9228786; uncharacterized protein 2405733 4979458 An02g09690 Aspergillus niger uncharacterized protein XP_001400098.1 2403836 R 5061 CDS An02g09700 84590420 join(2405937..2406056,2406129..2406208,2406327..2406446,2406549..2406631,2406729..2406857,2406924..2407093) IV 1 NT_166519.1 hypothetical protein 2407093 84590420 An02g09700 Aspergillus niger hypothetical protein XP_059600065.1 2405937 D 5061 CDS An02g09710 4979460 join(2407417..2407804,2407846..2407955) IV 1 NT_166519.1 hypothetical protein 2407955 4979460 An02g09710 Aspergillus niger hypothetical protein XP_059600066.1 2407417 D 5061 CDS An02g09720 4979461 complement(join(2408241..2409242,2409307..2409892,2409947..2410072,2410131..2410273,2410337..2410402,2410475..2410547,2410619..2410629)) IV 1 NT_166519.1 Catalytic activity: ATP + L-glutamate + L-cysteine = ADP + orthophosphate + gamma-L-glutamyl-L-cysteine.; Pathway: glutamate metabolism; glutathione metabolism.; Remark: a DNA fragment encoding gamma-glutamylcysteine synthetase [EC 6. 3. 2. 2] of Schizosaccharomyces pombe was cloned by complementation of the cadmium hypersensitivity of a S. pombe mutant deficient in the enzyme.; Title: strong similarity to gamma-glutamylcysteine synthase gcs1p - Schizosaccharomyces pombe; See PMID 7608113; See PMID 8619315; uncharacterized protein 2410629 4979461 An02g09720 Aspergillus niger uncharacterized protein XP_001400101.1 2408241 R 5061 CDS An02g09730 4979462 complement(join(2411693..2411797,2411886..2412010,2412103..2412154)) IV 1 NT_166519.1 Catalytic activity: NADH + ubiquinone <=> NAD(+) + ubiquinol.; Pathway: ubiquinone biosynthesis; oxidative phosphorylation.; Remark: strong similarity to Arabidopsis thaliana protein fragment SEQ ID NO: 4828 patent EP1033405-A2.; Remark: the homologues human protein was earlier proposed to be a cell adhesion protein.; Remark: the predicted ORF is 22 amino acids shorter at the N- and C-terminus than the CI-B18 chain of NADH:ubiquinone reductase from B. taurus.; Similarity: the ORF shows similarity to several ubiquinone oxidoreductases.; Title: similarity to 18 kD subunit of NADH:ubiquinone reductase CI-B18 - Bos taurus; See PMID 1518044; uncharacterized protein 2412154 4979462 An02g09730 Aspergillus niger uncharacterized protein XP_001400102.1 2411693 R 5061 CDS An02g09740 4979463 join(2412585..2412632,2412745..2412931,2412991..2414819,2414981..2415129,2415492..2415605,2415650..2415658,2415723..2415765) IV 1 NT_166519.1 Remark: in the fission yeast S. pombe, the 'start' of the cell cycle is controlled by the two functionally redundant transcriptional regulator complexes, Res1p-Cdc10p and Res2p-Cdc10p, that activate genes essential for the onset and progression of S phase.; Remark: res2+ in fission yeast is largely redundant in function with res1+ and is required for the initiation of mitotic and premeiotic DNA synthesis, but has an additional role in meiotic division. unlike res1+, res2+ is highly induced during conjugation and strongly depends on cdc10+ for its activity.; Title: strong similarity to cell cycle regulator res2p - Schizosaccharomyces pombe; See PMID 8168485; See PMID 10982385; uncharacterized protein 2415765 4979463 An02g09740 Aspergillus niger uncharacterized protein XP_001400103.3 2412585 D 5061 CDS An02g09770 84590421 join(2417471..2417569,2417653..2417880,2417974..2418114,2418232..2418396,2418561..2418630,2418722..2418879,2418947..2419054) IV 1 NT_166519.1 hypothetical protein 2419054 84590421 An02g09770 Aspergillus niger hypothetical protein XP_059600067.1 2417471 D 5061 CDS An02g09780 4979467 join(2419836..2420633,2420687..2421490,2421545..2421658) IV 1 NT_166519.1 Remark: S. cerevisiae normally will not take up sterols from the environment under aerobic conditions. A specific mutant, upc2-1, of the predicted transcriptional activator UPC2 (YDR213w) has been recognized as a strain that allows a high level of aerobic sterol uptake.; Remark: alternative name is YDR213w.; Similarity: to unassigned GAL4-type zinc cluster proteins; GAL4 zinc binuclear cluster homology.; Title: similarity to RNA polymerase II transcription factor Upc2 - Saccharomyces cerevisiae; See PMID 11208779; uncharacterized protein 2421658 4979467 An02g09780 Aspergillus niger uncharacterized protein XP_001400105.1 2419836 D 5061 CDS An02g09790 4979468 complement(join(2422421..2422632,2422710..2423112,2423174..2423697,2423765..2423885,2423938..2424163,2424212..2424287,2424398..2424473,2424551..2424667)) IV 1 NT_166519.1 Remark: strong similarity to Arabidopsis thaliana protein fragment SEQ ID NO: 38506 patent EP1033405-A2.; Remark: strong similarity to EST SEQ ID NO:4038 from Aspergillus niger.; Remark: the predicted ORF is a putative amino acid permease.; Similarity: to choline transport proteins.; Title: strong similarity to protein fragment SEQ ID NO:38506 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 2424667 4979468 An02g09790 Aspergillus niger uncharacterized protein XP_059600068.1 2422421 R 5061 CDS An02g09795 84590422 complement(2424995..2425282) IV 1 NT_166519.1 hypothetical protein 2425282 84590422 An02g09795 Aspergillus niger hypothetical protein XP_059600069.1 2424995 R 5061 CDS An02g09800 84590423 join(2425669..2425932,2426027..2426171,2426251..2426349,2426504..2426617,2426684..2426934) IV 1 NT_166519.1 hypothetical protein 2426934 84590423 An02g09800 Aspergillus niger hypothetical protein XP_059600070.1 2425669 D 5061 CDS An02g09810 4979471 join(2427273..2427369,2427435..2427996,2428048..2428137,2428191..2428194,2428244..2428306,2428364..2428624,2428676..2428793,2428825..2429295,2429347..2429499,2429552..2429692,2429736..2429897,2429943..2430113,2430157..2430411,2430456..2430589,2430639..2430785,2430830..2431002,2431038..2431231,2431279..2431353,2431400..2431431) IV 1 NT_166519.1 Catalytic activity: NADPH + NAD+ = NADP+ + NADH.; Function: the transhydrogenation between nadh and nadp is coupled to respiration and atp hydrolysis and functions as a proton pump across the membrane.; Pathway: nicotinate and nicotinamide metabolism.; Remark: a splice site upstream of the START codon was detected.; Remark: similarity to EST an_2187 from Aspergillus niger.; Remark: the mitochondrial energy-linked nicotinamide nucleotide transhydrogenase is a homodimer of monomer Mr = 109,228. Hydropathy analysis of its cDNA-deduced amino acid sequence (1043 residues) has indicated that the molecule is composed of 3 domains: a 430-residue-long hydrophilic N-terminal domain which binds NAD(H), a 200-residue-long hydrophilic C-terminal domain which binds NADP(H), and a 400-residue-long hydrophobic central domain which appears to be made up mainly of about 14 hydrophobic clusters of approximately 20 residues each.; Similarity: to E. coli transhydrogenase alpha- and beta-subunit and to alanine dehydrogenases.; Title: strong similarity to mitochondrial nicotinamide nucleotide transhydrogenase NNTM - Bos taurus; See PMID 3277960; See PMID 2005110; uncharacterized protein 2431431 4979471 An02g09810 Aspergillus niger uncharacterized protein XP_059600071.1 2427273 D 5061 CDS An02g09820 84590424 complement(join(2432437..2432509,2432573..2432664)) IV 1 NT_166519.1 Remark: the ORF is short in length (54 amino acids).; hypothetical protein 2432664 84590424 An02g09820 Aspergillus niger hypothetical protein XP_059600072.1 2432437 R 5061 CDS An02g09830 4979473 complement(2434429..2435916) IV 1 NT_166519.1 hypothetical protein 2435916 4979473 An02g09830 Aspergillus niger hypothetical protein XP_059600073.1 2434429 R 5061 CDS An02g09840 84590425 complement(join(2436502..2436682,2436762..2436845,2437145..2437271,2437369..2437446,2437662..2437819,2438094..2438152)) IV 1 NT_166519.1 hypothetical protein 2438152 84590425 An02g09840 Aspergillus niger hypothetical protein XP_059600074.1 2436502 R 5061 CDS An02g09850 84590426 join(2438368..2438480,2438579..2438681) IV 1 NT_166519.1 hypothetical protein 2438681 84590426 An02g09850 Aspergillus niger hypothetical protein XP_059600075.1 2438368 D 5061 CDS An02g09860 84590427 complement(join(2438757..2438847,2439073..2439129,2439190..2439321,2439400..2439467,2439555..2439593,2440291..2440343,2440415..2440502)) IV 1 NT_166519.1 Remark: the ORF has an unusual exon/intron structure for A. niger.; hypothetical protein 2440502 84590427 An02g09860 Aspergillus niger hypothetical protein XP_059600076.1 2438757 R 5061 CDS An02g09870 84590428 join(2440881..2440958,2441102..2441113,2441196..2441249) IV 1 NT_166519.1 Title: questionable ORF; uncharacterized protein 2441249 84590428 An02g09870 Aspergillus niger uncharacterized protein XP_059600077.1 2440881 D 5061 CDS An02g09880 84590429 complement(join(2441863..2442470,2442548..2443130)) IV 1 NT_166519.1 hypothetical protein 2443130 84590429 An02g09880 Aspergillus niger hypothetical protein XP_059600078.1 2441863 R 5061 CDS An02g09890 4979479 complement(join(2443896..2443916,2443979..2444278)) IV 1 NT_166519.1 Title: strong similarity to EST an_2336 -Aspergillus niger; uncharacterized protein 2444278 4979479 An02g09890 Aspergillus niger uncharacterized protein XP_001400117.1 2443896 R 5061 CDS An02g09900 84590430 complement(join(2444513..2444653,2444730..2444930,2445148..2445273,2445575..2445640)) IV 1 NT_166519.1 hypothetical protein 2445640 84590430 An02g09900 Aspergillus niger hypothetical protein XP_059600079.1 2444513 R 5061 CDS An02g09910 4979481 complement(join(2446265..2446605,2446655..2446937,2447007..2447411)) IV 1 NT_166519.1 Remark: FEN1 S. cerevisiae is involved in the synthesis of 1,3-beta-glucan, a component of the cell wall,and elongation of fatty acids up to 24 carbons .; Title: strong similarity to fatty acid elongase Fen1 - Saccharomyces cerevisiae; See PMID 9211877; uncharacterized protein 2447411 4979481 An02g09910 Aspergillus niger uncharacterized protein XP_001400119.1 2446265 R 5061 CDS An02g09920 84590431 join(2447486..2447705,2447790..2448130) IV 1 NT_166519.1 hypothetical protein 2448130 84590431 An02g09920 Aspergillus niger hypothetical protein XP_059600080.1 2447486 D 5061 CDS An02g09930 4979483 join(2449240..2449433,2449606..2449651,2449812..2449929,2450012..2450130) IV 1 NT_166519.1 Catalytic activity: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O.; Pathway: oxidative phosphorylation.; Remark: Cytochrome c oxidase (CcO) in S. cerevisiae is subject to intricate physiological control. Growth phase, carbon source, and oxygen level are three well recognized modulators of CcO expression.; Remark: strong similarity to EST an_2060 from Aspergillus niger.; Similarity: to mammalian cytochrome-c oxidase chain Va.; Title: strong similarity to subunit VI of cytochrome c oxidase Cox6 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 6210289; See PMID 6290493; See PMID 2537949; uncharacterized protein 2450130 4979483 An02g09930 Aspergillus niger uncharacterized protein XP_001400121.1 2449240 D 5061 CDS An02g09940 4979484 complement(join(2451098..2451254,2451316..2451934,2451991..2452254,2452337..2452493)) IV 1 NT_166519.1 Catalytic activity: transfers an alpha-D-mannosyl residue from GDPmannose into lipid--linked oligosaccharide,forming an alpha-1,2-D-mannosyl-D-mannose linkage.; Pathway: glycoprotein biosynthesis.; Remark: KTR1 S. cerevisiae utilizes mannose,methyl-alpha-mannoside, alpha-1,2-mannobiose and methyl-alpha-1,2-mannobiose, as well as Man15-30GlcNAc,derived from mnn2 mutant glycoproteins, as substrates. It did not utilize alpha-1,6-mannobiose, alpha-1,6-mannotriose, alpha-1,6-mannotetraose, mammalian Man9GlcNAc or yeast Man9-10GlcNAc.; Remark: glycosylation constitutes one of the most important of all the post-translational modifications and may have numerous effects on the function, structure,physical properties and targeting of particular proteins. Eukaryotic glycan structures are progressively elaborated in the secretory pathway. Following the addition of a core N-linked carbohydrate in the endoplasmic reticulum,glycoproteins move to the Golgi complex where the elongation of O-linked sugar chains and processing of complex N-linked oligosaccharide structures take place.; Similarity: belongs to the; Title: strong similarity to alpha-1,2-mannosyltransferase Ktr1 - Saccharomyces cerevisiae; See PMID 8631921; See PMID 9020857; See PMID 9878809; uncharacterized protein 2452493 4979484 An02g09940 Aspergillus niger uncharacterized protein XP_001400122.1 2451098 R 5061 CDS An02g09950 4979485 join(2452835..2452852,2452963..2455575) IV 1 NT_166519.1 Remark: GCP3 colocalizes with gamma-tubulin at the centrosome, cosediment with gamma-tubulin in sucrose gradients, and coimmunoprecipitate with gamma-tubulin,indicating that they are part of the gamma-tubulin complex. The yeast spindle pole body and the animal centrosome share a common molecular mechanism for microtubule nucleation.; Title: similarity to spindle pole body protein spc98 homolog GCP3 - Homo sapiens; See PMID 9566967; uncharacterized protein 2455575 4979485 An02g09950 Aspergillus niger uncharacterized protein XP_059600081.1 2452835 D 5061 CDS An02g09960 4979486 complement(2456100..2460185) IV 1 NT_166519.1 Catalytic activity: ATP + 5'-phosphoribosyl-N-formylglycinamide + L-glutamine + H2O = ADP + orthophosphate + 5'-phosphoribosyl-N-formylglycinamidine + L-glutamate.; Pathway: purine metabolism.; Remark: Escherichia coli 5'-phosphoribosylformylglycinamide (FGAR) amidotransferase (EC 6. 3. 5. 3) encoded by the purL gene catalyzes the conversion of FGAR to formylglycinamidine in the presence of glutamine and ATP for the de novo purine nucleotide biosynthesis.; Similarity: belongs to the phosphoribosylformylglycinamidine synthase family.; Title: strong similarity to phosphoribosylformylglycinamidine synthase purL -Escherichia coli; See PMID 2531746; See PMID 2659070; uncharacterized protein 2460185 4979486 An02g09960 Aspergillus niger uncharacterized protein XP_001400124.1 2456100 R 5061 CDS An02g09970 4979487 join(2461797..2462226,2462277..2462880,2462927..2463264,2463315..2463557,2463857..2464041) IV 1 NT_166519.1 Function: might be a membrane transporter used in A. chrysogenum to improve the fermentation ability.; Remark: strong similarity to A. chrysogenum cephalosporin C biosynthesis protein patent JP09009966-A.; Similarity: to multidrug transporters of diverse fungal species.; Title: strong similarity to cephalosporin C biosynthesis protein from patent JP09009966-A - Acremonium chrysogenum; uncharacterized protein 2464041 4979487 An02g09970 Aspergillus niger uncharacterized protein XP_059600082.1 2461797 D 5061 CDS An02g09980 84590432 join(2464151..2464250,2464311..2464573,2464656..2464726,2464803..2464881,2465159..2465446) IV 1 NT_166519.1 Title: similarity to hypothetical protein encoded by An01g14410 - Aspergillus niger; uncharacterized protein 2465446 84590432 An02g09980 Aspergillus niger uncharacterized protein XP_059600083.1 2464151 D 5061 CDS An02g09990 4979489 join(2465511..2466394,2466455..2466714,2466764..2466989,2467037..2468093) IV 1 NT_166519.1 Similarity: the N-terminus of the ORF shows local similarity to zinc-finger containing transcription factors.; Title: weak similarity to CYC1/CYP3 transcription activator Hap1 - Saccharomyces cerevisiae; See PMID 2851658; See PMID 2643482; uncharacterized protein 2468093 4979489 An02g09990 Aspergillus niger uncharacterized protein XP_059600084.1 2465511 D 5061 CDS An02g10000 4979490 complement(join(2468310..2468920,2468954..2469298,2469375..>2469681)) IV 1 NT_166519.1 Catalytic activity: 4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate.; Function: use of phenylalanine and phenylacetate as a carbon source.; Induction: by phenylacetate (PhOAc), 2OH-PhOAc,3OH-PhOAc, 4OH-PhOAc, phenylalanine, and tyrosine.; Induction: not induced by acetate or glutamate.; Pathway: last step in the metabolism of tyrosine.; Remark: N-terminal truncated ORF due to end of contig.; Remark: disruption of the fah gene results in phenylalanine toxicity, secretion of succinylacetone and the absence of growth. This is analogous to the genetic disease, type I hereditary tyrosinaemia (ht1) in humans.; Repression: expression is partially repressed by glucose.; Title: strong similarity to fumarylacetoacetate hydrolase fahA - Aspergillus nidulans [truncated ORF]; See PMID 7568087; uncharacterized protein 2469681 4979490 An02g10000 Aspergillus niger uncharacterized protein XP_059600085.1 2468310 R 5061 CDS An02g10010 84590433 complement(join(2471687..2472018,2472082..2472737,2472875..2473208,2473633..2473684)) IV 1 NT_166519.1 Function: D. buzzatii Osvaldo pol codes for a putative protease (PR), a reverse transcriptase/ribonuclease H (RT/RH), a integrase (IN), and a significant portion of the surface envelope (ENV) protein.; Remark: the predicted A. niger protein contains two possible sequencing errors at position 31867 and 32236.; Similarity: similarity is from the predicted A. niger protein to the N-terminal half of, which is 700 aa longer.; Title: similarity to retrotransposon Osvaldo gene pol - Drosophila buzzatii [putative pseudogene]; putative pseudogene; See PMID 10406108; uncharacterized protein 2473684 84590433 An02g10010 Aspergillus niger uncharacterized protein XP_059603455.1 2471687 R 5061 CDS An02g10020 84590434 join(2475442..2475528,2475687..2475728) IV 1 NT_166519.1 Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 2475728 84590434 An02g10020 Aspergillus niger uncharacterized protein XP_059603456.1 2475442 D 5061 CDS An02g10030 4979493 complement(join(2476365..2476662,2476761..2477080)) IV 1 NT_166519.1 Title: weak similarity to hypothetical protein encoded by An08g11120 - Aspergillus niger; uncharacterized protein 2477080 4979493 An02g10030 Aspergillus niger uncharacterized protein XP_059603457.1 2476365 R 5061 CDS An02g10040 4979494 complement(join(2479666..2480330,2480385..2480766)) IV 1 NT_166519.1 Catalytic activity: cinnamyl-alcohol dehydrogenases convert cinnamyl alcohol + NADP(+) to cinnamaldehyde + NADPH.; Function: E. gunnii CAD1 catalyses the conversion of p-hydroxy-cinnamaldehydes to the corresponding alcohols and is considered a key enzyme in lignin biosynthesis.; Function: E. gunnii CAD1 exhibits high affinity towards lignin precursors including 4-coumaraldehyde and coniferaldehyde, but does not accept sinapaldehyde, and recombinant CAD 1 can also utilize a wide range of aromatic substrates including unsubstituted and substituted benzaldehydes.; Title: strong similarity to cinnamyl alcohol dehydrogenase CAD1 - Eucalyptus gunnii; See PMID 9526508; uncharacterized protein 2480766 4979494 An02g10040 Aspergillus niger uncharacterized protein XP_001400132.1 2479666 R 5061 CDS An02g10050 4979495 complement(join(2481239..2482672,2482741..2483268,2483328..2483666,2483718..2483854,2483928..2484012,2484189..2484224)) IV 1 NT_166519.1 Remark: Schizosaccharomyces pombe thi1 gene acts as an activator of several thiamine-repressible genes which are involved in the control of thiamine metabolism.; Similarity: contains a zn(2)-cys(6), fungal-type binuclear cluster domain.; Title: similarity to transcription activator thi1p -Schizosaccharomyces pombe; nucleus; See PMID 8088540; uncharacterized protein 2484224 4979495 An02g10050 Aspergillus niger uncharacterized protein XP_059603458.1 2481239 R 5061 CDS An02g10060 4979496 complement(join(2485273..2485290,2485359..2485367,2485800..2485889,2485983..2486057,2486165..2486206,2486455..2486690,2486750..2487247,2487300..2487487,2487651..2487743,2487973..2488089,2488200..2488320,2488535..2488650,2488785..2488831)) IV 1 NT_166519.1 Title: weak similarity to regulator of beta-1,3-glucan synthase Hkr1 - Saccharomyces cerevisiae; See PMID 8113191; See PMID 8550469; uncharacterized protein 2488831 4979496 An02g10060 Aspergillus niger uncharacterized protein XP_059603459.1 2485273 R 5061 CDS An02g10070 84590435 join(2490111..2490260,2490327..2490404,2490502..2490645) IV 1 NT_166519.1 hypothetical protein 2490645 84590435 An02g10070 Aspergillus niger hypothetical protein XP_059603460.1 2490111 D 5061 CDS An02g10080 4979498 complement(join(2492921..2494215,2494280..2494388)) IV 1 NT_166519.1 Function: F. oxysporum P450foxy catalyzes the subterminal (-1 to -3) hydroxylation of fatty acids.; Function: the physiological roles of the terminal hydroxylation of fatty acids including those of F. oxysporum P450foxy are essentially unknown.; Localization: native F. oxysporum P450foxy was exclusively recovered in the membrane fraction of the fungal cells.; Remark: F. oxysporum P450foxy is a unique cytochrome P450 in that it is self-sufficient, which means that it can complete its function without the aid of other proteinaceous components such as NADPH-cytochrome P450 oxidoreductase (referred to as P450reductase).; Remark: N- and C-terminal homologies respectively suggest that F. oxysporum P450foxy is a fused protein of P450 and its reductase.; Remark: the Exon-Intron structure in the C-terminal region of the predicted A. niger protein is in accordance with the A. niger ESTs an_1826 and 1715.; Similarity: F. oxysporum P450foxy belongs to the CYP505 group of cytochrome P450s.; Similarity: similarity is from the predicted A. niger protein to the N-terminal half of F. oxysporum P450foxy, which is 600 aa longer.; Title: similarity to fatty-acid subterminal hydroxylase P450foxy - Fusarium oxysporum; See PMID 10995755; uncharacterized protein 2494388 4979498 An02g10080 Aspergillus niger uncharacterized protein XP_001400136.1 2492921 R 5061 CDS An02g10090 4979499 complement(join(2496018..2496534,2496625..2496929,2497008..2497100)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein encoded by An11g00960 - Aspergillus niger; uncharacterized protein 2497100 4979499 An02g10090 Aspergillus niger uncharacterized protein XP_001400137.1 2496018 R 5061 CDS An02g10100 4979500 complement(join(2497703..2498130,2498198..2499167)) IV 1 NT_166519.1 Localization: ER-localisation was determined by cytoimmunofluorescence studies using epitope-tagged mouse EP58.; Title: similarity to endoplasmic reticulum protein EP58 - Mus musculus; endoplasmatic reticulum; See PMID 11167020; uncharacterized protein 2499167 4979500 An02g10100 Aspergillus niger uncharacterized protein XP_001400138.1 2497703 R 5061 CDS An02g10110 4979501 complement(join(<2503089..2504740,2504814..2505902,2505959..2506472,2506543..2507581)) IV 1 NT_166519.1 Remark: a putative sequencing error results in an frameshift.; Title: strong similarity to ATP-binding cassette transporter abc1p - Schizosaccharomyces pombe [putative frameshift]; putative frameshift; See PMID 9037770; uncharacterized protein 2507581 4979501 An02g10110 Aspergillus niger uncharacterized protein XP_059603461.1 2503089 R 5061 CDS An02g10120 4979502 complement(2509097..2510146) IV 1 NT_166519.1 Title: similarity to hypothetical protein encoded by An07g01070 - Aspergillus niger; uncharacterized protein 2510146 4979502 An02g10120 Aspergillus niger uncharacterized protein XP_001400140.1 2509097 R 5061 CDS An02g10130 84590436 join(2510664..2510811,2510855..2511210) IV 1 NT_166519.1 hypothetical protein 2511210 84590436 An02g10130 Aspergillus niger hypothetical protein XP_059603462.1 2510664 D 5061 CDS An02g10140 4979504 complement(join(2512001..2512381,2512487..2514787)) IV 1 NT_166519.1 Similarity: to proteins involved in non-ribosomal protein biosynthesis and polyketide synthesis.; Title: strong similarity to o peptide-polyketide synthase McyG - Microcystis aeruginosa; See PMID 11033079; uncharacterized protein 2514787 4979504 An02g10140 Aspergillus niger uncharacterized protein XP_059603463.1 2512001 R 5061 CDS An02g10150 4979505 join(2515727..2516075,2516128..2516426,2516488..2516982,2517047..2517595) IV 1 NT_166519.1 Title: similarity to hypothetical dehydratase/racemase - Rhodococcus erythropolis; uncharacterized protein 2517595 4979505 An02g10150 Aspergillus niger uncharacterized protein XP_001400143.1 2515727 D 5061 CDS An02g10160 4979506 join(2518436..2518509,2518578..2518646,2518702..2518786,2518845..2518950,2519009..2519081,2519143..2519296,2519362..2519375,2519437..2519860,2519938..2520225) IV 1 NT_166519.1 Catalytic activity: L-kynurenine + 2-oxoglutarate <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate; Cofactor: Pyridoxal-phosphate.; Remark: Also acts on 3-hydroxykynurenine.; Title: strong similarity to kynurenine aminotransferase - Rattus sp.; See PMID 7926014; uncharacterized protein 2520225 4979506 An02g10160 Aspergillus niger uncharacterized protein XP_001400144.1 2518436 D 5061 CDS An02g10170 4979507 join(2521170..2521557,2521610..2521702,2521758..2522680) IV 1 NT_166519.1 Remark: Lactic acid efflux from white skeletal muscle is catalyzed by the monocarboxylate transporter isoform MCT3. MCT3 is the major MCT isoform responsible for efflux of glycolytically derived lactic acid from white skeletal muscle.; Title: similarity to monocarboxylate transporter MCT3 - Rattus norvegicus; See PMID 9632638; uncharacterized protein 2522680 4979507 An02g10170 Aspergillus niger uncharacterized protein XP_001400145.3 2521170 D 5061 CDS An02g10180 4979508 join(2523152..2523248,2523305..2524058,2524131..2524523,2524581..2524831,2524934..2525499) IV 1 NT_166519.1 Remark: The cut9 gene encodes a 78-kD protein containing the 10 34-amino acid repeats, tetratricopeptide repeats (TPR), and is similar to budding yeast Cdc16.; Title: strong similarity to anaphase control protein cut9p - Schizosaccharomyces pombe; See PMID 7798319; uncharacterized protein 2525499 4979508 An02g10180 Aspergillus niger uncharacterized protein XP_059603464.1 2523152 D 5061 CDS An02g10190 4979509 join(2525822..2525844,2525908..2525970,2526032..2526096,2526173..2526864) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein BAB14757.1 - Homo sapiens; uncharacterized protein 2526864 4979509 An02g10190 Aspergillus niger uncharacterized protein XP_001400147.1 2525822 D 5061 CDS An02g10200 4979510 complement(join(2527157..2527840,2527892..2538691,2538765..2538922,2539042..2539135)) IV 1 NT_166519.1 Remark: TRRAP is an essential cofactor for the tanscription factors c-Myc and E2F.; Title: strong similarity to protein TRRAP - Homo sapiens; See PMID 9708738; uncharacterized protein 2539135 4979510 An02g10200 Aspergillus niger uncharacterized protein XP_001400148.1 2527157 R 5061 CDS An02g10210 4979511 complement(join(2540473..2540818,2540883..2541010,2541068..2541238,2541300..2541653,2541720..2542319,2542434..2542538,2542877..2542900)) IV 1 NT_166519.1 Title: strong similarity to protein phosphatase PP2A0 B subunit gamma isoform - Oryctolagus cuniculus; See PMID 8576224; uncharacterized protein 2542900 4979511 An02g10210 Aspergillus niger uncharacterized protein XP_059603465.1 2540473 R 5061 CDS An02g10220 4979512 join(2544724..2544864,2544921..2545230,2545290..2545367,2545420..2545528,2545586..2546882) IV 1 NT_166519.1 Remark: human transcription factor IIIC (hTFIIIC) is a multisubunit complex that mediates transcription of class III genes through direct recognition of promoters (for tRNA and virus-associated RNA genes) or promoter-TFIIIA complexes (for the 5S RNA gene) and subsequent recruitment of TFIIIB and RNA polymerase III.; Title: similarity to transcription factor IIIC63 -Homo sapiens; See PMID 10373544; uncharacterized protein 2546882 4979512 An02g10220 Aspergillus niger uncharacterized protein XP_059603466.1 2544724 D 5061 CDS An02g10230 4979513 complement(join(2547429..2548390,2548457..2548571)) IV 1 NT_166519.1 Title: similarity to hypothetical protein CAD11786.1 - Neurospora crassa; uncharacterized protein 2548571 4979513 An02g10230 Aspergillus niger uncharacterized protein XP_001400151.1 2547429 R 5061 CDS An02g10240 84590437 complement(join(2549889..2550011,2550056..2550210,2550432..2550540)) IV 1 NT_166519.1 hypothetical protein 2550540 84590437 An02g10240 Aspergillus niger hypothetical protein XP_059603467.1 2549889 R 5061 CDS An02g10250 84590438 2552427..2553488 IV 1 NT_166519.1 Title: weak similarity to hypothetical reverse transcriptase - Glomerella cingulata; uncharacterized protein 2553488 84590438 An02g10250 Aspergillus niger uncharacterized protein XP_059603468.1 2552427 D 5061 CDS An02g10260 4979516 complement(join(2553763..2554255,2554323..2555728,2555783..2555909,2555975..2556111)) IV 1 NT_166519.1 Remark: Fission yeast genes nda1 and nda4, mutations of which lead to S-phase block, chromatin alteration and Ca2+ suppression, are members of the CDC46/MCM2 family.; Title: strong similarity to cell division protein nda4p - Schizosaccharomyces pombe; See PMID 8298187; uncharacterized protein 2556111 4979516 An02g10260 Aspergillus niger uncharacterized protein XP_001400154.1 2553763 R 5061 CDS An02g10270 4979517 join(2556660..2556879,2556940..2559787,2559840..2560023) IV 1 NT_166519.1 Complex: S. cerevisiae Vps52p, Vps53p, and Vps54p are associated in a 1:1:1 complex.; Function: Vps52p, Vps53p, and Vps54p are required for the retrograde transport of Golgi membrane proteins from an endosomal/prevacuolar compartment.; Golgi; Phenotype: S. cerevisiae LUV1 mutants lack a morphologically intact vacuole and instead accumulate small vesicles that are acidified and contain the vacuolar proteins alkaline phosphatase and carboxypeptidase Y and the vacuolar membrane H(+)-ATPase.; Remark: alternative gene names for S. cerevisiae VPS54 are YDR027C, LUV1, RKI1 or TCS3.; Similarity: the ORF overlaps with the A. niger EST an_3009 (EMBLEST:BE758766).; Title: strong similarity to protein involved in vacuolar protein sorting Vps54 - Saccharomyces cerevisiae; See PMID 10888679; uncharacterized protein 2560023 4979517 An02g10270 Aspergillus niger uncharacterized protein XP_001400155.1 2556660 D 5061 CDS An02g10280 4979518 complement(join(2560402..2560578,2560644..2560736)) IV 1 NT_166519.1 Remark: the ORF is short in length (89 amino acids).; hypothetical protein 2560736 4979518 An02g10280 Aspergillus niger hypothetical protein XP_001400156.1 2560402 R 5061 CDS An02g10290 84590439 join(2561624..2561686,2561810..2561860,2562076..2562114,2562251..2562595) IV 1 NT_166519.1 Remark: the ORF has an unusual exon/intron structure for A. niger.; hypothetical protein 2562595 84590439 An02g10290 Aspergillus niger hypothetical protein XP_059603469.1 2561624 D 5061 CDS An02g10300 84590440 complement(join(2562627..2562674,2562728..2562837,2562857..2562992)) IV 1 NT_166519.1 Remark: the ORF has short length (97 amino acids).; hypothetical protein 2562992 84590440 An02g10300 Aspergillus niger hypothetical protein XP_059603470.1 2562627 R 5061 CDS An02g10310 4979521 join(2563431..2563895,2563961..2565323,2565376..2565571,2565647..2565764) IV 1 NT_166519.1 Function: the glycogen synthase of N. crassa synthesizes starch (glycogen) by addition of glucose moieties.; Pathway: the glycogen synthase of N. crassa is involved in glycogen biosynthesis.; Remark: the glycogen synthase of N. crassa belongs to the mammalian/fungal glycogen synthase family.; Remark: the glycogen synthase of N. crassa is inactivated at 45 degrees, thus glycogen accumulation shifts to trehalose accumulation.; Similarity: the ORF overlaps with the A. niger EST an_2027 at it's C-terminus.; Title: strong similarity to glycogen synthase -Neurospora crassa; See PMID 8549797; uncharacterized protein 2565764 4979521 An02g10310 Aspergillus niger uncharacterized protein XP_001400159.1 2563431 D 5061 CDS An02g10320 4979522 join(2567160..2567194,2567270..2567441,2567510..2567659,2567719..2568390) IV 1 NT_166519.1 Induction: expression of the nmt1 gene of A. parasiticus is inhibited by thiamine (2. 0 microM).; Remark: nmt1 of A. parasiticus belongs to the nmt1 family.; Remark: nmt1 of A. parasiticus is presumably involved in the thiamine biosynthesis (vitamine B1).; Similarity: the ORF overlaps with the A. niger EST an_0381 at it's C-terminus.; Similarity: the ORF overlaps with the A. niger patent WO200056762-A2 at it's C-terminus.; Similarity: the ORF shows strong similarity also to other proteins involved in thiamine/pyrimidine biosynthesis.; Title: strong similarity to protein nmt1 -Aspergillus parasiticus; See PMID 7711083; uncharacterized protein 2568390 4979522 An02g10320 Aspergillus niger uncharacterized protein XP_001400160.1 2567160 D 5061 CDS An02g10330 4979523 complement(join(2568695..2570149,2570231..2570635)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein BAC67939.1 - Streptomyces avermitilis; uncharacterized protein 2570635 4979523 An02g10330 Aspergillus niger uncharacterized protein XP_059603471.1 2568695 R 5061 CDS An02g10340 4979524 join(2572101..2572598,2572894..2574303) IV 1 NT_166519.1 Remark: the ORF has a - for A. niger - long intron (295 nucleotides).; hypothetical protein 2574303 4979524 An02g10340 Aspergillus niger hypothetical protein XP_001400162.3 2572101 D 5061 CDS An02g10350 4979525 complement(join(2574517..2575440,2575508..2575624)) IV 1 NT_166519.1 Function: the FPPS protein of G. fujikuroi is a key enzyme in isoprenoid biosynthesis.; Induction: the FPPS protein of G. fujikuroi is not regulated by light induction.; Remark: the FPPS polypeptide chain from G. fujikuroi carries two activities: a dimethylallyltranstransferase (EC: 2. 5. 1. 1) and a geranyltranstransferase (EC: 2. 5. 1. 10) activity.; Title: strong similarity to farnesyl-pyrophosphate synthase FPPS - Gibberella fujikuroi; See PMID 8753652; uncharacterized protein 2575624 4979525 An02g10350 Aspergillus niger uncharacterized protein XP_001400163.1 2574517 R 5061 CDS An02g10360 4979526 join(2576231..2576554,2576639..2576671,2576720..2577058,2577111..2577294,2577348..2578059,2578243..2578390) IV 1 NT_166519.1 Complex: CDC23 is a component of the APC (anaphase-promoting complex).; Function: CDC23 of S. cerevisiae is required for cell cycle progression through the G2/M transition.; Function: CDC23 of S. cerevisiae is required for chromosome segregation.; Remark: the APC plays a key role in the regulation of mitosis by triggering the separation of sister chromatids at the metaphase-anaphase transition.; Similarity: 90 N-terminal amino acids of the ORF are not homologous to CDC23 of S. cerevisiae; the alignment of the two proteins includes five extended gaps.; Title: strong similarity to cell division control protein Cdc23 - Saccharomyces cerevisiae; nucleus; See PMID 8423787; uncharacterized protein 2578390 4979526 An02g10360 Aspergillus niger uncharacterized protein XP_059603472.1 2576231 D 5061 CDS An02g10370 4979527 complement(join(<2578611..2580651,2580704..2580770,2580846..2581853)) IV 1 NT_166519.1 Function: DNA ligases IV ligate DNA and thereby hydrolyze ATP.; Function: DNA ligases IV presumably function in V(D)J recombination and non-homologous end-joining of DNA double-strand breaks.; Remark: DNA ligase IV of H. sapiens belongs to the ATP-dependent DNA ligase family.; Remark: a putative sequencing error results in an frameshift.; Similarity: the ORF is C-terminally 190 amino acids longer than lig4 of H. sapiens; the two proteins are aligned until amino acid 652.; Similarity: the similarity of the ORF to the hypothetical protein 15E6. 90 of N. crassa is much higher than to known DNA ligases.; Title: similarity to DNA ligase IV lig4 - Homo sapiens [putative frameshift]; nucleus; putative frameshift; See PMID 7760816; See PMID 9363683; See PMID 9539976; uncharacterized protein 2581853 4979527 An02g10370 Aspergillus niger uncharacterized protein XP_059603473.1 2578611 R 5061 CDS An02g10380 4979528 complement(join(2582242..2583855,2583916..2584005)) IV 1 NT_166519.1 Complex: SAP 61 of H. sapiens is part of the heterotrimeric splicing factor SF3a together with SAP 62,and 114.; Function: spliceosome-associated proteins are involved in pre-mRNA splicing.; Function: spliceosome-associated proteins are required for U2 snRNP binding to the pre-mRNA.; Remark: SAP 61 of H. sapiens is associated with pre-mRNA in spliceosomal complexes and with U2 snRNP.; Title: strong similarity to spliceosome-associated protein SAP61 - Homo sapiens; nucleus; See PMID 8022796; uncharacterized protein 2584005 4979528 An02g10380 Aspergillus niger uncharacterized protein XP_059603474.1 2582242 R 5061 CDS An02g10390 4979529 join(2584282..2584312,2584374..2584628,2584683..2585872) IV 1 NT_166519.1 Complex: eukaryotic translation initiation factors 4A function as a subunit of the initiation factor complex elF4F, which mediates the binding of mRNA to the ribosome (cap recognition).; Function: eukaryotic translation initiation factors 4A are ATP-dependent RNA helicases.; Function: eukaryotic translation initiation factors 4A unwind secondary structure in the 5'-untranslated region of mRNA,; Function: eukaryotic translation initiation factors' 4A activity is a prerequisite for mRNA binding to ribosomes.; Remark: eIF-4A II of M. musculus is differently high expressed in various organs.; Remark: eukaryotic translation initiation factors 4A belong to the 'DEAD' box family of helicases.; Similarity: the ORF has ca. 100 C-terminal additional amino acids, not found in eIF-4AII of M. musculus and other species.; Title: strong similarity to eukaryotic translation initiation factor eIF-4A II - Mus musculus; See PMID 11333019; See PMID 11418588; See PMID 3046931; uncharacterized protein 2585872 4979529 An02g10390 Aspergillus niger uncharacterized protein XP_059603475.1 2584282 D 5061 CDS An02g10400 4979530 complement(join(2587052..2587166,2587232..2587379,2587429..2587918,2587966..2588560,2588590..2589191)) IV 1 NT_166519.1 Similarity: similarity is restricted to C-terminus of the protein.; Title: strong similarity to GTP-binding associated protein #28 from patent WO200105970-A2 - Homo sapiens; uncharacterized protein 2589191 4979530 An02g10400 Aspergillus niger uncharacterized protein XP_059603476.1 2587052 R 5061 CDS An02g10405 84590441 complement(join(2589710..2589751,2589913..2590039,2590094..2590152)) IV 1 NT_166519.1 hypothetical protein 2590152 84590441 An02g10405 Aspergillus niger hypothetical protein XP_059603477.1 2589710 R 5061 CDS An02g10410 84590442 2590977..2591198 IV 1 NT_166519.1 Remark: possible sequencing error.; Title: strong similarity to EST an_3055 -Aspergillus niger [putative frameshift]; uncharacterized protein 2591198 84590442 An02g10410 Aspergillus niger uncharacterized protein XP_059603478.1 2590977 D 5061 CDS An02g10420 4979533 complement(join(2592884..2593002,2593041..2593211,2593287..2593310,2593529..2593772,2593830..2594453,2594675..2595031)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein CAB91439.2 - Neurospora crassa; uncharacterized protein 2595031 4979533 An02g10420 Aspergillus niger uncharacterized protein XP_059603479.1 2592884 R 5061 CDS An02g10430 84590443 complement(join(2595176..2595393,2595883..2596051)) IV 1 NT_166519.1 Title: questionable ORF; uncharacterized protein 2596051 84590443 An02g10430 Aspergillus niger uncharacterized protein XP_059603480.1 2595176 R 5061 CDS An02g10440 4979535 join(2596074..2596181,2596276..2596360,2596423..2597090,2597150..2598046,2598100..2598156) IV 1 NT_166519.1 Catalytic activity: ATP + H2O = ADP + Orthophosphate.; Function: the vacuolar ATPase generates an acidic interior and drives the transport of small molecules in vacuoles, storing large amounts of phosphate and basic amino acids.; Remark: the vacuolar ATPase is a large enzyme,composed of 8-10 subunits that are arranged into two sectors, a complex consisting of peripheral subunits (V1) and an integral membrane complex (V0).; Remark: the vma-1 gene of N. crassa encodes the largest, non-integral catalytic subunit of the active enzyme.; Title: strong similarity to H+-transporting ATPase vma-1 - Neurospora crassa; vacuole; See PMID 8722770; See PMID 1400281; See PMID 1491233; See PMID 2142943; See PMID 2971651; uncharacterized protein 2598156 4979535 An02g10440 Aspergillus niger uncharacterized protein XP_001400173.1 2596074 D 5061 CDS An02g10450 4979536 join(2598854..2598879,2598948..2599017,2599093..2599187,2599262..2600009,2600059..2600700,2600750..2601008,2601062..2601146,2601196..2601364) IV 1 NT_166519.1 Function: VPS1 binds microtubules and could also be involved in microtubule-associated motility.; Function: VPS1 interacts with the mvp1 protein.; Function: the VPS1 protein (vacuolar sorting protein 1) of S. cerevisiae is essential for protein sorting in meiotic cell division.; Function: the VPS1 protein is necessary for membrane protein retention in a late golgi compartment.; Golgi; Similarity: belongs to the dynamin family.; Title: strong similarity to GTP-binding protein Vps1 - Saccharomyces cerevisiae; See PMID 9372190; uncharacterized protein 2601364 4979536 An02g10450 Aspergillus niger uncharacterized protein XP_001400174.1 2598854 D 5061 CDS An02g10460 4979537 complement(join(2603085..2603251,2603297..2603372,2603467..2603639,2603703..2604115,2604177..2604265,2604331..2604375)) IV 1 NT_166519.1 Remark: the Nitrilase family contains hydrolases that break carbon-nitrogen bond and appear to be involved in the reduction of organic nitrogen compounds and ammonia production.; Similarity: contains Carbon-nitrogen hydrolase Pfam domain.; Similarity: similarity to nitrilases.; Title: similarity to protein fragment SEQ ID NO:63238 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 2604375 4979537 An02g10460 Aspergillus niger uncharacterized protein XP_059603481.1 2603085 R 5061 CDS An02g10470 4979538 join(2605196..2605363,2605420..2606256) IV 1 NT_166519.1 Similarity: similarity to esterases and lipases (EC 3. 1. 1. - and 2. 3. 1. -) involved in metabolism of vitamins, co-factors, lipids and fatty-acids.; Title: similarity to protein fragment SEQ ID NO:22341 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 2606256 4979538 An02g10470 Aspergillus niger uncharacterized protein XP_001400176.1 2605196 D 5061 CDS An02g10480 4979539 join(2606544..2607011,2607054..2607244,2607556..2607742) IV 1 NT_166519.1 Catalytic activity: 2 RH + 2 chloride + H(2)O(2) = 2 RCl + 2 H(2)O.; Function: catalyzes peroxidative halogenations involved in the biosynthesis of clardariomycin (2,2-dichloro-1,3-cyclo-pentenedione), the enzyme also has potent catalase activity and in the absence of halide ion,acts as a peroxidase similar to plant peroxidases.; Remark: brings about the chlorination of a range of organic molecules, forming stable C-Cl bonds.; Title: similarity to chloride peroxidase cpo -Leptoxyphium fumago; See PMID 3771564; uncharacterized protein 2607742 4979539 An02g10480 Aspergillus niger uncharacterized protein XP_059603482.1 2606544 D 5061 CDS An02g10490 4979540 join(2608373..2608764,2608815..2609268,2609326..2609670) IV 1 NT_166519.1 Catalytic activity: endohydrolysis of 1,3- or 1,4-linkages in beta-d-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3.; Title: strong similarity to endo-1,3(4)-beta-glucanase bg1 - Phaffia rhodozyma; plasma membrane; uncharacterized protein 2609670 4979540 An02g10490 Aspergillus niger uncharacterized protein XP_001400178.1 2608373 D 5061 CDS An02g10500 84590444 complement(join(2610987..2611330,2611536..2611605,2611689..2611716,2611758..2611805,2611851..2611891)) IV 1 NT_166519.1 Similarity: weak similarity (partial) to Guanylate kinase (E. C. 2. 7. 4. 8) S. cerevisiae.; hypothetical protein 2611891 84590444 An02g10500 Aspergillus niger hypothetical protein XP_059603483.1 2610987 R 5061 CDS An02g10510 84590445 join(2612039..2612099,2612156..2612235) IV 1 NT_166519.1 hypothetical protein 2612235 84590445 An02g10510 Aspergillus niger hypothetical protein XP_059603484.1 2612039 D 5061 CDS An02g10520 84590446 complement(join(2612895..2613016,2613109..2613186,2613294..2613417,2613502..2613728,2613995..2614117,2614165..2614405)) IV 1 NT_166519.1 hypothetical protein 2614405 84590446 An02g10520 Aspergillus niger hypothetical protein XP_059603485.1 2612895 R 5061 CDS An02g10530 84590447 complement(join(2614547..2614739,2614805..2614855,2615000..2615073)) IV 1 NT_166519.1 hypothetical protein 2615073 84590447 An02g10530 Aspergillus niger hypothetical protein XP_059603486.1 2614547 R 5061 CDS An02g10540 84590448 join(2615133..2615293,2615519..2615625,2615717..2615904) IV 1 NT_166519.1 hypothetical protein 2615904 84590448 An02g10540 Aspergillus niger hypothetical protein XP_059603487.1 2615133 D 5061 CDS An02g10550 4979546 join(2616084..2616338,2616401..2616877,2616944..2617029,2617106..2617244) IV 1 NT_166519.1 Catalytic activity: endohydrolysis of 1,5-alpha-l-arabinofuranosidic linkages in 1,5-arabinans.; Function: the prefered substrate of A. niger ABN A protein is linear 1,5-alpha-l-arabinan, the enzyme activity is progressively reduced as 1,5-alpha-chains become shorter or more highly substituted.; Induction: by l-araban, arabinogalactan and l-arabitol.; Pathway: involved in degradation of the plant cell wall polysaccharide l-arabinan.; Similarity: belongs to family 43 of glycosyl hydrolases.; Title: strong similarity to endo-alpha-1,5-arabinanase abnA - Aspergillus niger; plasma membrane; See PMID 7764386; See PMID 8000538; uncharacterized protein 2617244 4979546 An02g10550 Aspergillus niger uncharacterized protein XP_001400184.1 2616084 D 5061 CDS An02g10560 4979547 2618997..2620058 IV 1 NT_166519.1 Similarity: contains ankyrin repeat domain.; Similarity: similarity is restricted to C-terminus of Murine protein kinase/ankyrin homologue SEQ ID no:334.; Title: similarity to protein kinase/ankyrin homologue SEQ ID NO:334 from patent WO9955865-A1 - Mus musculus; uncharacterized protein 2620058 4979547 An02g10560 Aspergillus niger uncharacterized protein XP_001400185.1 2618997 D 5061 CDS An02g10570 84590449 join(2620679..2620791,2621238..2621352) IV 1 NT_166519.1 Title: questionable ORF; uncharacterized protein 2621352 84590449 An02g10570 Aspergillus niger uncharacterized protein XP_059603488.1 2620679 D 5061 CDS An02g10580 4979549 complement(2622938..2625379) IV 1 NT_166519.1 Title: similarity to hypothetical protein CAD21354.1 - Neurospora crassa; uncharacterized protein 2625379 4979549 An02g10580 Aspergillus niger uncharacterized protein XP_059603489.1 2622938 R 5061 CDS An02g10590 84590450 join(2625516..2625553,2625598..2625751) IV 1 NT_166519.1 hypothetical protein 2625751 84590450 An02g10590 Aspergillus niger hypothetical protein XP_059603490.1 2625516 D 5061 CDS An02g10600 84590451 join(2626060..2626158,2626273..2626380) IV 1 NT_166519.1 hypothetical protein 2626380 84590451 An02g10600 Aspergillus niger hypothetical protein XP_059603491.1 2626060 D 5061 CDS An02g10610 4979552 complement(join(2627552..2627927,2627994..2628123,2628186..2628711,2628766..2628862,2628920..2628941,2629013..2629170,2629232..2629449,2629510..2629578)) IV 1 NT_166519.1 Similarity: similarity is restricted to C-terminus.; Title: weak similarity to hypothetical protein Cj0814 - Campylobacter jejuni; uncharacterized protein 2629578 4979552 An02g10610 Aspergillus niger uncharacterized protein XP_001400190.1 2627552 R 5061 CDS An02g10620 4979553 join(2630090..2630206,2630277..2632047,2632112..2632140,2632198..2632692) IV 1 NT_166519.1 Similarity: similarity corresponds to multiple alanine repeats.; Similarity: weak similarity to putative secreted protein SC4A7. 11 - Streptomyces coelicolor.; hypothetical protein 2632692 4979553 An02g10620 Aspergillus niger hypothetical protein XP_001400191.1 2630090 D 5061 CDS An02g10630 84590452 complement(join(2633209..2633234,2633299..2635039,2635192..2635215)) IV 1 NT_166519.1 Similarity: contains ATP/GTP-binding site motif A (P-loop).; Title: strong similarity to hypothetical protein encoded by An08g09830 - Aspergillus niger; uncharacterized protein 2635215 84590452 An02g10630 Aspergillus niger uncharacterized protein XP_059603492.1 2633209 R 5061 CDS An02g10640 84590453 join(2636184..2636901,2636956..2637413) IV 1 NT_166519.1 Similarity: only partial similarity.; Title: weak similarity to hypothetical protein CAB55016.2 - Caenorhabditis elegans; uncharacterized protein 2637413 84590453 An02g10640 Aspergillus niger uncharacterized protein XP_059603493.1 2636184 D 5061 CDS An02g10650 84590454 join(2637653..2637806,2637846..2637901) IV 1 NT_166519.1 hypothetical protein 2637901 84590454 An02g10650 Aspergillus niger hypothetical protein XP_059603494.1 2637653 D 5061 CDS An02g10660 4979557 complement(join(2638428..2638458,2638610..2639321,2639389..2639408,2639520..2639731)) IV 1 NT_166519.1 Function: the beta subunit of H. sapiens methionine adenosyltransferase MATII has regulatory function.; Remark: Methionine adenosyltransferase (MAT; S-adenosyl-L-methionine synthetase, EC 2. 5. 1. 6)1 is an essential enzyme that catalyzes the synthesis of S-adenosylmethionine (AdoMet) from L-methionine (L-Met) and ATP, the major methyl group donor, participating in the methylation of proteins, DNA, RNA, phospholipids, and other small molecules.; Remark: the H. sapiens methionine adenosyltransferase consists of catalytic alpha(2)/alpha(2') subunits and a noncatalytic beta subunit.; Title: strong similarity to methionine adenosyltransferase regulatory beta subunit MAT II - Homo sapiens; cytoplasm; See PMID 10644686; uncharacterized protein 2639731 4979557 An02g10660 Aspergillus niger uncharacterized protein XP_001400195.3 2638428 R 5061 CDS An02g10670 4979558 join(2640535..2642139,2642189..2642221) IV 1 NT_166519.1 Catalytic activity: (R)-Lactate + 2 Ferricytochrome c = Pyruvat + 2 Ferrocytochrome c.; Similarity: no N-terminal similarity.; Title: strong similarity to protein D-lactate dehydrogenase YEL071w - Saccharomyces cerevisiae; See PMID 10509019; uncharacterized protein 2642221 4979558 An02g10670 Aspergillus niger uncharacterized protein XP_001400196.1 2640535 D 5061 CDS An02g10680 4979559 join(2642905..2643388,2643491..2643882) IV 1 NT_166519.1 Catalytic activity: estradiol-17-beta + NAD(+) = estrone + NADH.; Complex: homodimer.; Function: favors the reduction of estrogens and androgens, also has 20-alpha-hsd activity, uses preferentially NADH.; Localization: cytoplasmic.; Pathway: biosynthesis of estrogens.; Similarity: belongs to the short-chain dehydrogenases/reductases family (sdr).; Title: strong similarity to estradiol 17beta-dehydrogenase E2DH - Homo sapiens; uncharacterized protein 2643882 4979559 An02g10680 Aspergillus niger uncharacterized protein XP_001400197.1 2642905 D 5061 CDS An02g10690 4979560 complement(join(2644010..2644596,2644653..2644912,2644959..2645584,2645836..2645859)) IV 1 NT_166519.1 Title: weak similarity to cercosporin resistance protein crg1 - Cercospora nicotianae; uncharacterized protein 2645859 4979560 An02g10690 Aspergillus niger uncharacterized protein XP_059603495.1 2644010 R 5061 CDS An02g10700 4979561 complement(join(2646803..2647227,2647286..2648381)) IV 1 NT_166519.1 Catalytic activity: RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.; Function: CYP52A3-A of C. maltosa catalyses the terminal hydroxylation of n-alkanes.; Induction: CYP52A3-A of C. maltosa is induced by alkanes.; Pathway: CYP52A3-A of C. maltosa catalyses the first step of n-alkane assimilation.; Title: strong similarity to alkane-hydroxylating cytochrome P-450 CYP52A3-A - Candida maltosa; See PMID 1368716; See PMID 2735924; uncharacterized protein 2648381 4979561 An02g10700 Aspergillus niger uncharacterized protein XP_001400199.1 2646803 R 5061 CDS An02g10710 4979562 join(2649901..2649949,2650017..2650084,2650159..2650326,2650380..2650981,2651035..2651667,2651732..2651999) IV 1 NT_166519.1 Function: severin kinase of D. discoideum is involved in signal transduction from the plasma membrane to the cytoskeleton by phosphorylation of actin-binding proteins.; Function: severin kinase of D. discoideum phosphorylates severin, a Ca2+-dependent F-actin fragmenting protein, enabling rapid rearrangement of the actin cytoskeleton.; Similarity: belongs to the Ste20p- or p21-activated protein kinase family.; Title: strong similarity to severin kinase -Dictyostelium discoideum; cytoplasm; See PMID 9582328; uncharacterized protein 2651999 4979562 An02g10710 Aspergillus niger uncharacterized protein XP_001400200.1 2649901 D 5061 CDS An02g10720 84590455 complement(join(2653014..2653385,2653433..2653552)) IV 1 NT_166519.1 hypothetical protein 2653552 84590455 An02g10720 Aspergillus niger hypothetical protein XP_059603496.1 2653014 R 5061 CDS An02g10730 4979564 join(2653632..2655079,2655167..2655371) IV 1 NT_166519.1 Title: similarity to hypothetical protein CAD21413.1 - Neurospora crassa; uncharacterized protein 2655371 4979564 An02g10730 Aspergillus niger uncharacterized protein XP_001400202.1 2653632 D 5061 CDS An02g10740 4979565 join(2655916..2656026,2656106..2656201,2656275..2656613) IV 1 NT_166519.1 Function: TIM22 of N. crassa is essential for mitochondrial import of AAC-class carrier proteins.; Function: TIM22 of N. crassa is involved in targeting of nuclear-encoded preproteins with internal targeting signals to the mitochondrial inner membrane.; Title: strong similarity to mitochondrial inner membrane translocase component TIM22 - Neurospora crassa; localisation:mitochondrion; See PMID 9368075; See PMID 11405338; uncharacterized protein 2656613 4979565 An02g10740 Aspergillus niger uncharacterized protein XP_001400203.1 2655916 D 5061 CDS An02g10750 4979566 complement(join(2657473..2658470,2658532..2658652)) IV 1 NT_166519.1 Catalytic activity: O3-acetyl-L-serine + H2S = L-cysteine + acetate; Function: the catalytic activity of cysB of A. nidulans requires pyridoxal-phosphate as a cofactor.; Remark: cysB of A. nidulans is also named O-acetylserine (thiol)-lyase.; Title: strong similarity to cysteine synthase cysB -Aspergillus nidulans; See PMID 9108143; uncharacterized protein 2658652 4979566 An02g10750 Aspergillus niger uncharacterized protein XP_001400204.1 2657473 R 5061 CDS An02g10760 4979567 join(2659241..2661289,2661340..2662638) IV 1 NT_166519.1 Function: the condensin complex of S. pombe is essential for mitotic chromosome condensation.; Localization: condensin of S. pombe translocates from the cytoplasm to the nucleus during mitosis due to phosphorylation by Cdc2.; Similarity: also shows strong similarity to the condensin complex component cnd3 of Schizosaccharomyces pombe (see PMID reference).; Title: strong similarity to essential protein AN97 from patent WO9924580-A2 - Aspergillus nidulans; See PMID 10485849; uncharacterized protein 2662638 4979567 An02g10760 Aspergillus niger uncharacterized protein XP_001400205.1 2659241 D 5061 CDS An02g10770 84590456 join(2663673..2663852,2663905..2663923,2664074..2664104,2664223..2664262) IV 1 NT_166519.1 Title: questionable ORF; uncharacterized protein 2664262 84590456 An02g10770 Aspergillus niger uncharacterized protein XP_059603497.1 2663673 D 5061 CDS An02g10780 4979569 join(2664933..2665085,2665286..2665343,2665514..2666178,2666245..2667165) IV 1 NT_166519.1 Function: Ran-binding proteins regulate the interaction between Ran-GTPase and the nucleoporin complex.; Pathway: the interaction of Ran-GTPase with the nucleoporin complex controls the nuclear export pathway.; Similarity: contains a putative zinc finger domain of the Ran-binding protein family.; Title: strong similarity to hypothetical RNA-binding zinc finger protein CAB11213.1 - Schizosaccharomyces pombe; uncharacterized protein 2667165 4979569 An02g10780 Aspergillus niger uncharacterized protein XP_059605672.1 2664933 D 5061 CDS An02g10790 4979570 join(2668676..2668703,2668778..2668784,2668840..2668892,2668979..2669366,2669446..2669782) IV 1 NT_166519.1 Complex: the eukaryotic proteasome core forms a highly ordered ring-like complex consisiting of 28 distinct subunits. the S. cerevisiae homolog Pre6p is the alpha-4 subunit of the 20S proteasome core.; Function: eukaryotic proteasome complexes are involved in non-lysosomal degradation of misformed and/or short-lived proteins.; Localization: the proteasome of S. cerevisiae has been shown to be localized mainly at the nuclear envelope-endoplasmic reticulum network.; Title: strong similarity to proteasome 20S subunit Pre6 - Saccharomyces cerevisiae; See PMID 7918444; See PMID 9799224; uncharacterized protein 2669782 4979570 An02g10790 Aspergillus niger uncharacterized protein XP_001400208.1 2668676 D 5061 CDS An02g10800 4979571 complement(join(2670079..2670160,2670229..2670330,2670473..2670534,2670597..2670670,2670737..2670780,2670855..2670861,2671169..2671196)) IV 1 NT_166519.1 Title: strong similarity to hypothetical zinc-finger protein SPBC3B9.05 - Schizosaccharomyces pombe; uncharacterized protein 2671196 4979571 An02g10800 Aspergillus niger uncharacterized protein XP_001400209.3 2670079 R 5061 CDS An02g10810 4979572 join(2671676..2671723,2671790..2674235,2674285..2674494,2674541..2674800,2674849..2675516,2675608..2675620) IV 1 NT_166519.1 Similarity: the C-terminus shows homology to synaptojanin-like IPP phosphatases which are involved in the control of vesicle recycling (see PMID reference).; Title: strong similarity to hypothetical polyphosphoinositide phosphatase B18D24.60 - Neurospora crassa; See PMID 10931870; uncharacterized protein 2675620 4979572 An02g10810 Aspergillus niger uncharacterized protein XP_059605673.1 2671676 D 5061 CDS An02g10820 84590457 join(2675916..2676111,2676172..2676311) IV 1 NT_166519.1 hypothetical protein 2676311 84590457 An02g10820 Aspergillus niger hypothetical protein XP_059605674.1 2675916 D 5061 CDS An02g10830 4979578 join(2678699..2678833,2678889..2680286) IV 1 NT_166519.1 Function: ATR1 of S. cerevisiae confers resistance to aminotriazole and 4-nitroquinoline-N-oxide.; Remark: the systematic gene name of ATR1 of S. cerevisiae is YML116w.; Similarity: belongs to the major facilitator superfamily (MFS).; Title: strong similarity to aminotriazole resistance protein Atr1 - Saccharomyces cerevisiae; plasma membrane; See PMID 2123132; See PMID 3280970; uncharacterized protein 2680286 4979578 An02g10830 Aspergillus niger uncharacterized protein XP_001400212.1 2678699 D 5061 CDS An02g10840 4979579 join(2680766..2681699,2681764..>2682357) IV 1 NT_166519.1 Function: P450rm of R. minuta catalyses the formation of isobutene from isovalerate and the 4-hydroxylation of benzoate.; Pathway: P450rm of R. minuta functions in the degradation of L-phenylalanine on the pathway to beta-ketoadipate.; Remark: a putative sequencing error results in an frameshift.; Similarity: belongs to the CYP53 family of cytochromes P450.; Title: strong similarity to bifunctional cytochrome P450rm - Rhodotorula minuta [putative frameshift]; endoplasmatic reticulum; putative frameshift; See PMID 7764227; See PMID 8882724; See PMID 9349702; uncharacterized protein 2682357 4979579 An02g10840 Aspergillus niger uncharacterized protein XP_059605675.1 2680766 D 5061 CDS An02g10850 84590458 complement(join(<2682443..2682570,2682622..2682718,2682775..2682833,2682909..2683033,2683072..2683931,2683992..2683998,2684150..2684358,2684478..2684584,2684645..2684653)) IV 1 NT_166519.1 Remark: possible sequencing error at position 13159 leading to a frameshift which would destroy the zinc-finger domain.; Similarity: contains a fungal-type Zn(2)-Cys(6) binuclear cluster DNA-binding domain.; Title: similarity to hypothetical transcription regulator of arginine catabolism arcA - Aspergillus nidulans [putative frameshift]; putative frameshift; uncharacterized protein 2684653 84590458 An02g10850 Aspergillus niger uncharacterized protein XP_059605676.1 2682443 R 5061 CDS An02g10860 84590459 join(2685672..2685920,2685966..2686195,2686326..2686347,2686575..2686616,2686846..2686932) IV 1 NT_166519.1 Title: weak similarity to hypothetical protein encoded by An19g00070 - Aspergillus niger; uncharacterized protein 2686932 84590459 An02g10860 Aspergillus niger uncharacterized protein XP_059605677.1 2685672 D 5061 CDS An02g10870 4979582 complement(join(2687039..2687066,2687159..2687223,2687353..2687547,2687648..2687807,2687865..2688241,2688307..2688578,2688722..2688827,2688916..2688960)) IV 1 NT_166519.1 Localization: PTH11 of M. porthe is an integral plasma membrane protein.; Remark: contains five putative transmembrane domains.; Similarity: PTH11 of M. porthe is almost twice as long.; Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea; uncharacterized protein 2688960 4979582 An02g10870 Aspergillus niger uncharacterized protein XP_059605678.1 2687039 R 5061 CDS An02g10880 84590460 complement(join(2689883..2689941,2689993..2690267,2690325..2690380)) IV 1 NT_166519.1 hypothetical protein 2690380 84590460 An02g10880 Aspergillus niger hypothetical protein XP_059605679.1 2689883 R 5061 CDS An02g10890 4979584 join(2691627..2692604,2692655..2692846) IV 1 NT_166519.1 Catalytic activity: catalyzes prenylation of para-hydroxybenzoate.; Pathway: second step in coenzyme Q biosynthesis pathway; Remark: disruption of the chromosomal COQ2 gene indicates the gene is not essential for viability, yet is required for PHB:polyprenyltransferase activity and respiratory function.; Title: strong similarity to para-hydroxybenzoate-polyprenyltransferase Coq2 -Saccharomyces cerevisiae; See PMID 1740455; uncharacterized protein 2692846 4979584 An02g10890 Aspergillus niger uncharacterized protein XP_059605680.1 2691627 D 5061 CDS An02g10900 4979585 complement(join(2694018..2694146,2694266..2694280,2694351..2694401,2694683..2695151,2695213..2695256)) IV 1 NT_166519.1 Title: similarity to hypothetical protein encoded by An10g00180 - Aspergillus niger; uncharacterized protein 2695256 4979585 An02g10900 Aspergillus niger uncharacterized protein XP_059605681.1 2694018 R 5061 CDS An02g10910 84590461 complement(join(2698918..2699044,2699132..2699280,2699361..2699414)) IV 1 NT_166519.1 hypothetical protein 2699414 84590461 An02g10910 Aspergillus niger hypothetical protein XP_059605682.1 2698918 R 5061 CDS An02g10920 4979587 join(2699532..2699582,2699639..2700070,2700128..2701717) IV 1 NT_166519.1 Catalytic activity: RCH2NH2 + H2O = RCHO + NH3 + H2O2.; Localization: using transmission electron microscopy, the amine oxidase activity in Aspergillus niger AKU 3302 was localized to the outer side of the cell wall but not inside the cell using the cerium perhydroxide deposition method.; Pathway: glycine, serine and threonine metabolism; arginine and proline metabolism; histidine metabolism; tyrosine metabolism; phenylalanine metabolism; tryptophan metabolism; beta-alanine metabolism; alkaloid biosynthesis II.; Remark: northern blot analysis indicated that AO-I was highly expressed in A. niger grown on n-butylamine as a single nitrogen source.; Similarity: belongs to the amine oxidases (copper-containing). AO-I from A. niger belongs to the copper/topaquinone oxidase family.; Title: strong similarity to copper amine oxidase AO-I - Aspergillus niger; See PMID 8620882; See PMID 10896215; uncharacterized protein 2701717 4979587 An02g10920 Aspergillus niger uncharacterized protein XP_059605683.1 2699532 D 5061 CDS An02g10930 4979588 complement(2702178..2703425) IV 1 NT_166519.1 Remark: strong similarity to Corynebacterium glutamicum HA protein sequence SEQ ID NO:386 patent WO200100842-A2.; Remark: the predicted ORF represents a probable nadh-dependent flavin oxidoreductase by similarity.; Title: strong similarity to HA protein sequence SEQ ID NO:386 from patent WO200100842-A2 - Corynebacterium glutamicum; uncharacterized protein 2703425 4979588 An02g10930 Aspergillus niger uncharacterized protein XP_059605684.1 2702178 R 5061 CDS An02g10940 4979589 complement(join(2703995..2705605,2705739..2705783)) IV 1 NT_166519.1 Function: StcS of A. nidulans is involved in the conversion of versicolorin A to demethylsterigmatocystin.; Pathway: StcS of A. nidulans is involved in the sterigmatocystin biosynthesis.; Remark: sterigmatocystin is a polyketide-derived mycotoxin.; Similarity: belongs to the cytochrome P450 family.; Title: strong similarity to cytochrome P450 monooxygenase stcS - Aspergillus nidulans; See PMID 8643646; See PMID 10618248; See PMID 7486998; uncharacterized protein 2705783 4979589 An02g10940 Aspergillus niger uncharacterized protein XP_059605685.1 2703995 R 5061 CDS An02g10950 84590462 join(2705853..2705886,2705973..2706060,2706279..2706462,2706553..2706672) IV 1 NT_166519.1 hypothetical protein 2706672 84590462 An02g10950 Aspergillus niger hypothetical protein XP_059605686.1 2705853 D 5061 CDS An02g10960 4979591 join(2707063..2707158,2707223..2707688,2707736..2707828,2707877..2708415) IV 1 NT_166519.1 Similarity: the hypothetical A. niger protein with similarity to this ORF is described with weak similarity to the integral membrane protein PTH11 of M. grisea.; Title: similarity to hypothetical protein encoded by An12g05390 - Aspergillus niger; uncharacterized protein 2708415 4979591 An02g10960 Aspergillus niger uncharacterized protein XP_059605687.1 2707063 D 5061 CDS An02g10970 4979592 join(2708897..2709804,2709865..2709979) IV 1 NT_166519.1 Similarity: belongs to the dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases).; Title: similarity to sequence 6 from patent WO0144446-A6 - Homo sapiens; uncharacterized protein 2709979 4979592 An02g10970 Aspergillus niger uncharacterized protein XP_001400226.1 2708897 D 5061 CDS An02g10980 4979593 2710714..2711562 IV 1 NT_166519.1 Remark: similarity to A. niger ESTs an_3449, an_2275, an_3290 and an_2495.; Similarity: the ORF shows weak similarity to another A. niger protein.; Title: similarity to hypothetical glutathione S-transferase BAB68404.1 - Gibberella fujikuroi; uncharacterized protein 2711562 4979593 An02g10980 Aspergillus niger uncharacterized protein XP_001400227.3 2710714 D 5061 CDS An02g10990 84590463 complement(join(2711679..2712157,2712390..2712693,2713061..2713642)) IV 1 NT_166519.1 Similarity: the ORF shows similarity to another A. niger protein. This other protein displays similarity to the cercosporin resistance protein Crg1 of Cercospora nicotianae.; Title: similarity to hypothetical protein encoded by An17g00650 - Aspergillus niger; uncharacterized protein 2713642 84590463 An02g10990 Aspergillus niger uncharacterized protein XP_059605688.1 2711679 R 5061 CDS An02g11000 4979595 join(2714085..2714152,2714216..2715320) IV 1 NT_166519.1 Catalytic activity: 2 farnesyl diphosphate = pyrophosphate + presqualene diphosphate; presqualene diphosphate = pyrophosphate + cyclopropylcarbinyl cation; cyclopropylcarbinyl cation + NADPH = squalene + NADP+.; Pathway: sterol biosynthesis; terpenoid biosynthesis.; Remark: the yeast Candida utilis does not possess an endogenous biochemical pathway for the synthesis of carotenoids. The central isoprenoid pathway concerned with the synthesis of prenyl lipids is present in C. utilis and active in the biosynthesis of ergosterol.; Remark: through metabolic engineering of the isoprenoid pathway, a sevenfold increase in the yield of lycopene has been achieved. The influential steps in the pathway that were manipulated were 3-hydroxy methylglutaryl coenzyme A (HMG-CoA) reductase, encoded by the HMG gene,and squalene synthase, encoded by the ERG9 gene.; Similarity: belongs to the; Title: strong similarity to squalene synthase ERG9 -Candida utilis; See PMID 8474436; See PMID 9647847; uncharacterized protein 2715320 4979595 An02g11000 Aspergillus niger uncharacterized protein XP_001400229.3 2714085 D 5061 CDS An02g11010 4979596 join(2715948..2716052,2716122..2717336) IV 1 NT_166519.1 Title: weak similarity to hypothetical protein encoded by An14g05440 - Aspergillus niger; uncharacterized protein 2717336 4979596 An02g11010 Aspergillus niger uncharacterized protein XP_001400230.3 2715948 D 5061 CDS An02g11020 84590464 complement(join(2717984..2718070,2718298..2718348,2718437..2718507,2718553..2718731,2718799..2718881)) IV 1 NT_166519.1 hypothetical protein 2718881 84590464 An02g11020 Aspergillus niger hypothetical protein XP_059605689.1 2717984 R 5061 CDS An02g11030 4979598 2718934..2720235 IV 1 NT_166519.1 Catalytic activity: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine.; Pathway: propanoate metabolism.; Remark: ACC synthase from P. citrinum had 430 amino acid residues and a shorter C terminal than the plant enzyme. The enzyme purified from Escherichia coli transformed with ACC-synthase-encoding DNA showed similar properties to those of the purified enzyme from P. citrinum. S. cerevisiae with ACC synthase accumulated ACC in the medium with increasing time of incubation.; Similarity: belongs to the 1-aminocyclopropane-1-carboxylate synthases.; Title: strong similarity to ACC synthase acs -Penicillium citrinum; See PMID 11515533; uncharacterized protein 2720235 4979598 An02g11030 Aspergillus niger uncharacterized protein XP_001400232.1 2718934 D 5061 CDS An02g11040 4979599 complement(join(2720330..2721280,2721333..2722545,2722640..2722743)) IV 1 NT_166519.1 Catalytic activity: citrate = isocitrate.; Pathway: citrate cycle (TCA cycle); glyoxylate and dicarboxylate metabolism; reductive carboxylate cycle (CO2 fixation).; Remark: aconitase has an active (4fe-4s) and an inactive (3fe-4s) forms. the active (4fe-4s) cluster is part of the catalytic site that interconverts citrate,cis-aconitase, and isocitrate.; Remark: an iron-sulfur protein. cis-Aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3-tricarboxylate. Also converts isocitrate into cis-aconitate.; Similarity: belongs to the aconitase/ipm isomerase family.; Title: strong similarity to mitochondrial aconitate hydratase Aco1 - Saccharomyces cerevisiae; See PMID 10490611; See PMID 1972545; uncharacterized protein 2722743 4979599 An02g11040 Aspergillus niger uncharacterized protein XP_059605690.1 2720330 R 5061 CDS An02g11050 4979600 complement(join(2722961..2723671,2723732..2724598)) IV 1 NT_166519.1 Remark: disruption of STL1 had no detectable effect on yeast growth on glucose, galactose, mannose, maltose or glycerol as sole carbon source.; Similarity: belongs to the sugar transporter family.; Title: strong similarity to sugar transport protein Stl1 - Saccharomyces cerevisiae; See PMID 8076821; uncharacterized protein 2724598 4979600 An02g11050 Aspergillus niger uncharacterized protein XP_001400234.1 2722961 R 5061 CDS An02g11060 4979601 complement(2725215..2726360) IV 1 NT_166519.1 Remark: strong similarity to Neisseria meningitidis sequence 43 patent FR2785293-A/43 and patent WO200026375-A2.; Title: strong similarity to sequence 43 from patent FR2785293-A - Neisseria meningitidis; uncharacterized protein 2726360 4979601 An02g11060 Aspergillus niger uncharacterized protein XP_001400235.1 2725215 R 5061 CDS An02g11070 4979602 complement(join(2726942..2728826,2728924..2729168)) IV 1 NT_166519.1 Function: the yeast gene is a positive regulator of URA1 and URA3 expression.; Remark: PPR1 is a yeast transcription factor that contains a six-cysteine, two-zinc (Zn) domain, homologous to a similar structure in GAL4. Like GAL4, it binds to DNA sites with conserved CGG triplets symmetrically placed near each end. Whereas the GAL4 site has 11 intervening base pairs, the PPR1 site has 6.; Remark: the S. cerevisiae gene PPR1 encodes a positive regulator of the expression of the two unlinked structural genes URA1 and URA3.; Similarity: belongs to the unassigned GAL4-type zinc cluster proteins.; Title: similarity to regulator protein Ppr1 -Saccharomyces cerevisiae; See PMID 7958913; See PMID 11297736; See PMID 6096561; See PMID 6096562; uncharacterized protein 2729168 4979602 An02g11070 Aspergillus niger uncharacterized protein XP_001400236.3 2726942 R 5061 CDS An02g11080 4979603 complement(join(2729259..2729710,2729769..2730235,2730281..2730327)) IV 1 NT_166519.1 Catalytic activity: catalyzes the conversion of 2-pyrone-4,6-dicarboxylate + H2O to oxalomesaconate.; Pathway: involved in the phthalate catabolic pathway.; Title: similarity to 2-pyrone-4,6-dicarboxylate hydrolase pcmC - Arthrobacter keyseri; See PMID 11371533; uncharacterized protein 2730327 4979603 An02g11080 Aspergillus niger uncharacterized protein XP_001400237.1 2729259 R 5061 CDS An02g11090 4979604 join(2730633..2730744,2730791..2730831,2730902..2730997,2731058..2731528,2731581..2731805) IV 1 NT_166519.1 Localization: Yhm2p S. cerevisiae is localized in the mitochondrial inner membrane and is also associated with mitochondrial DNA in vivo.; Remark: Yhm2p S. cerevisiae exhibits general DNA-binding activity in vitro. Yhm2p may function as a member of the protein machinery for the mitochondrial inner membrane attachment site of mitochondrial DNA during replication and segregation of mitochondrial genomes.; Remark: alternative name is YMR241w.; Title: strong similarity to suppressor gene of mitochondrial histone Yhm2 - Saccharomyces cerevisiae; See PMID 9742088; uncharacterized protein 2731805 4979604 An02g11090 Aspergillus niger uncharacterized protein XP_001400238.1 2730633 D 5061 CDS An02g11100 84590465 complement(join(2731947..2731998,2732054..2732307,2732424..2732659,2733048..2733183,2733258..2733353)) IV 1 NT_166519.1 hypothetical protein 2733353 84590465 An02g11100 Aspergillus niger hypothetical protein XP_059605691.1 2731947 R 5061 CDS An02g11110 84590466 complement(join(2733453..2733584,2733802..2733894)) IV 1 NT_166519.1 Title: questionable ORF; uncharacterized protein 2733894 84590466 An02g11110 Aspergillus niger uncharacterized protein XP_059605692.1 2733453 R 5061 CDS An02g11120 4979607 join(2734458..2734732,2734902..2735056,2735124..2735503,2735562..>2736122) IV 1 NT_166519.1 Remark: C-terminal truncated ORF due to end of contig.; Remark: strong similarity to Arabidopsis thaliana OPT family member emb CAB10414. 1 patent WO200052162-A2.; Remark: the ORF represents a putative mammalian enkephalin transport proteins for transporting enkephalin across cell membrane.; Title: strong similarity to oligopeptide transporter family member emb CAB10414.1 from patent WO200052162-A2 -Arabidopsis thaliana [truncated ORF]; uncharacterized protein 2736122 4979607 An02g11120 Aspergillus niger uncharacterized protein XP_059605693.1 2734458 D 5061 CDS An02g11130 84590467 join(<2736228..2736701,2736750..2736869) IV 1 NT_166519.1 Function: isp4 of S. pombe was originally identified by subctractive screening as gene induced during the sexual differentiation process.; Function: subsequently, it was demonstrated that isp4 of S. pombe is a membrane oligopeptide transporter.; Remark: N-terminal truncated ORF due to end of contig.; Similarity: the predicted A. niger protein shows strong similarity to isp4 of S. pombe, which belongs to a group of transporters specific for small oligopeptides,which is called the OPT family (from the C. albicans OPT1 gene).; Title: strong similarity to protein isp4p -Schizosaccharomyces pombe [truncated ORF]; plasma membrane; See PMID 9643541; See PMID 7954893; uncharacterized protein 2736869 84590467 An02g11130 Aspergillus niger uncharacterized protein XP_059603498.1 2736228 D 5061 CDS An02g11140 4979650 join(2737607..2737996,2738054..2738644) IV 1 NT_166519.1 Catalytic activity: PT1 of P. taeda catalyzes the reduction of the benzylic ether bond of dehydrodiconiferyl alcohol and dihydrodehydrodiconiferyl alchool to produce,respectively, isodihydrodehydrodiconyferyl alcohol and tetrahydrodehydrodiconiferyl alcohol.; Function: these compounds, as many other phenylpropanoids, are crucial for plant defense mechanisms,especially against fungal infections.; Title: similarity to phenylcoumaran benzylic ether reductase PT1 - Pinus taeda; See PMID 10066819; uncharacterized protein 2738644 4979650 An02g11140 Aspergillus niger uncharacterized protein XP_001400243.1 2737607 D 5061 CDS An02g11150 4979651 join(2739381..2739449,2739512..2739644,2739696..2739836,2739902..2739991,2740050..2740352,2740440..2740624,2740715..2741125) IV 1 NT_166519.1 Catalytic activity: alpha-galactosidase from A. niger catalyses the reaction melibiose + H(2)O = galactose + glucose.; Function: alpha-galactosidase participates in the hydrolysis of complex plant saccharides such as galacto(gluco)mannans.; Gene-ID: aglB; Remark: in A. niger, there are three known genes encoding alpha-galactosidase, aglA, aglB and aglC.; extracellular/secretion proteins; See PMID 10347026; alpha-galactosidase aglB-Aspergillus niger 2741125 aglB 4979651 aglB Aspergillus niger alpha-galactosidase aglB-Aspergillus niger XP_001400244.1 2739381 D 5061 CDS An02g11160 4979652 complement(join(2741240..2742566,2742619..2742923)) IV 1 NT_166519.1 Similarity: the ORF shows strong similarity to the A. niger EST an_3218.; Title: strong similarity to hypothetical protein CAD70913.1 - Neurospora crassa; uncharacterized protein 2742923 4979652 An02g11160 Aspergillus niger uncharacterized protein XP_001400245.1 2741240 R 5061 CDS An02g11170 4979653 join(2743969..2744224,2744297..2744549,2744606..2744720) IV 1 NT_166519.1 Similarity: the predicted A. niger protein shows similarity to hypothetical proteins of several procaryotic species.; Title: similarity to hypothetical protein PA2706 -Pseudomonas aeruginosa; uncharacterized protein 2744720 4979653 An02g11170 Aspergillus niger uncharacterized protein XP_001400246.1 2743969 D 5061 CDS An02g11180 4979654 join(2745255..2745697,2745760..2746087,2746138..2746248) IV 1 NT_166519.1 Title: strong similarity to EST an_0208 -Aspergillus niger; uncharacterized protein 2746248 4979654 An02g11180 Aspergillus niger uncharacterized protein XP_001400247.1 2745255 D 5061 CDS An02g11190 4979655 join(2746664..2746939,2747010..2747168) IV 1 NT_166519.1 Similarity: the predicted A. niger protein shows strong similarity to protein fragment SEQ ID NO: 75556 of patent EP1033405-A2 (Acc. # AAG58521) from Z. mays and many conserved hypothetical proteins from procaryotic and eucaryotic organisms.; Title: strong similarity to protein fragment SEQ ID NO:75556 from patent EP1033405-A2 - Zea mays; uncharacterized protein 2747168 4979655 An02g11190 Aspergillus niger uncharacterized protein XP_001400248.1 2746664 D 5061 CDS An02g11200 4979656 complement(join(2747410..2747538,2747589..2747756,2747877..2748458)) IV 1 NT_166519.1 Title: similarity to 13 kD subunit of NADH:ubiquionen reductase - Bos taurus; localisation:mitochondrion; putative frameshift; uncharacterized protein 2748458 4979656 An02g11200 Aspergillus niger uncharacterized protein XP_001400249.3 2747410 R 5061 CDS An02g11210 4979657 join(2748533..2748601,2748667..2749056,2749107..2749274) IV 1 NT_166519.1 Title: weak similarity to hypothetical protein CG4548 - Drosophila melanogaster; uncharacterized protein 2749274 4979657 An02g11210 Aspergillus niger uncharacterized protein XP_001400250.1 2748533 D 5061 CDS An02g11220 84590468 complement(join(2749356..2749834,2749879..2750095)) IV 1 NT_166519.1 hypothetical protein 2750095 84590468 An02g11220 Aspergillus niger hypothetical protein XP_059603499.1 2749356 R 5061 CDS An02g11230 4979659 complement(2750516..2751343) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein YDR196c - Saccharomyces cerevisiae; uncharacterized protein 2751343 4979659 An02g11230 Aspergillus niger uncharacterized protein XP_001400252.1 2750516 R 5061 CDS An02g11240 84590469 complement(join(2751682..2751885,2751962..2752051,2752114..2752119)) IV 1 NT_166519.1 hypothetical protein 2752119 84590469 An02g11240 Aspergillus niger hypothetical protein XP_059603500.1 2751682 R 5061 CDS An02g11250 84590470 complement(join(2752329..2752474,2752522..2752637,2752839..2752921,2752996..2753046,2753125..2753220)) IV 1 NT_166519.1 hypothetical protein 2753220 84590470 An02g11250 Aspergillus niger hypothetical protein XP_059603501.1 2752329 R 5061 CDS An02g11260 4979662 complement(join(2755797..2756138,2756188..2756572,2756631..2756687,2756738..2756779,2756831..2757024,2757088..2757172,2757226..2757416,2757491..2757690,2757773..2757857)) IV 1 NT_166519.1 Function: monosaccharide transporter Mst-1 of A. muscaria is involved in the active uptake of monosaccharides.; Induction: monosaccharide transporter Mst-1 of A. muscaria is upregulated in ectomycorrhizas by a monosaccharide-controlled mechanism.; Similarity: the predicted A. niger protein shows strong similarity to the monosaccharide transporter Mst-1 of A. muscaria, which belongs to the sugar transporter family.; Title: strong similarity to monosaccharide transporter AmMst-1 - Amanita muscaria; plasma membrane; See PMID 9487692; uncharacterized protein 2757857 4979662 An02g11260 Aspergillus niger uncharacterized protein XP_001400255.1 2755797 R 5061 CDS An02g11270 4979663 join(2759303..2759788,2760099..2760986) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein EAA63528.1 - Aspergillus nidulans; uncharacterized protein 2760986 4979663 An02g11270 Aspergillus niger uncharacterized protein XP_059603502.1 2759303 D 5061 CDS An02g11280 4979664 complement(join(2760996..2762144,2762165..2762629,2762700..2762830,2762962..2763136)) IV 1 NT_166519.1 Title: weak similarity to transcription regulator of arginine catabolism arcA - Aspergillus nidulans; uncharacterized protein 2763136 4979664 An02g11280 Aspergillus niger uncharacterized protein XP_059603503.1 2760996 R 5061 CDS An02g11290 4979665 complement(join(2763748..2763913,2763977..2764571,2764639..2765247,2765428..2765485,2765706..2766062)) IV 1 NT_166519.1 Catalytic activity: 1-phosphatidyl-1D-myo-inositol 4, 5-bisphosphate + H(2) <=> D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.; Function: Plc1 from S. pombe is a 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase.; Function: activated by all classes of cell surface receptors, Plc proteins generate the ubiquitous second messengers inositol 1,4,5-trisphosphate and diacylglycerol.; Phenotype: the mutant plc1-1 of S. pombe is unable to grow on a minimal medium containing high amounts of phosphate.; Title: similarity to phosphoinositide-specific phospholipase C lc1p - Schizosaccharomyces pombe; See PMID 11015615; See PMID 7732727; See PMID 8590474; uncharacterized protein 2766062 4979665 An02g11290 Aspergillus niger uncharacterized protein XP_059603504.1 2763748 R 5061 CDS An02g11300 4979666 complement(join(2767915..2768165,2768236..2768713)) IV 1 NT_166519.1 Remark: Yml37 from S. cerevisiae is a mitochondrial ribosomal protein of the large subunit.; Remark: synonyms for Yml37 from S. cerevisiae are Mrpl37 and YBR268w.; Title: similarity to mitochondrial ribosomal protein of the large subunit Yml37 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9151978; mitochondrial 54S ribosomal protein mL54 2768713 4979666 An02g11300 Aspergillus niger mitochondrial 54S ribosomal protein mL54 XP_001400259.1 2767915 R 5061 CDS An02g11310 84590471 join(2769720..2769730,2769818..2769868,2769925..2769957,2770129..2770234) IV 1 NT_166519.1 Title: questionable ORF; uncharacterized protein 2770234 84590471 An02g11310 Aspergillus niger uncharacterized protein XP_059603505.1 2769720 D 5061 CDS An02g11320 4979668 complement(join(2771241..2771852,2771898..2772527)) IV 1 NT_166519.1 Remark: about the patent is no further information available.; Remark: the matching coding sequence was isolated by carrying out RT-PCR on all of the mRNA obtained from A. thaliana.; Similarity: the ORF encoded protein shows also strong similarities to epimerases.; Title: strong similarity to protein fragment SEQ ID NO:15392 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 2772527 4979668 An02g11320 Aspergillus niger uncharacterized protein XP_059603506.1 2771241 R 5061 CDS An02g11330 4979669 join(2773489..2773706,2773909..2774266,2774565..2774888) IV 1 NT_166519.1 Induction: the mRNA for spherulin 4 of P. polycephalum protein accumulates during spherulation.; Remark: spherulin 4 of P. polycephalum has many features of a plasma membrane protein: a signal peptide and a long hydrophobic region, which could serve as a transmembrane anchor.; Title: similarity to developmentally regulated spherulin 4 - Physarum polycephalum; See PMID 2930775; uncharacterized protein 2774888 4979669 An02g11330 Aspergillus niger uncharacterized protein XP_001400262.1 2773489 D 5061 CDS An02g11340 84590472 complement(join(2775782..2775857,2775901..2775937,2776068..2776173,2776204..2776232,2776376..2776489,2776586..2776682)) IV 1 NT_166519.1 Title: weak similarity to hypothetical protein encoded by B13I18.180 - Neurospora crassa; uncharacterized protein 2776682 84590472 An02g11340 Aspergillus niger uncharacterized protein XP_059603507.1 2775782 R 5061 CDS An02g11350 84590473 join(2778271..2778277,2778377..2778495,2778541..2778639,2778733..2778796,2779373..2779538,2779732..2779804) IV 1 NT_166519.1 Title: questionable ORF; uncharacterized protein 2779804 84590473 An02g11350 Aspergillus niger uncharacterized protein XP_059603508.1 2778271 D 5061 CDS An02g11360 4979672 complement(2780243..2781214) IV 1 NT_166519.1 Similarity: the similarities to lower scored matches are mainly based on repetetive structures.; Title: strong similarity to hypothetical endo alpha-1,4 polygalactosaminidase precusor - Pseudomonas sp.; uncharacterized protein 2781214 4979672 An02g11360 Aspergillus niger uncharacterized protein XP_001400265.1 2780243 R 5061 CDS An02g11380 84590474 complement(2784884..2786560) IV 1 NT_166519.1 Remark: ORF contains 5 frameshifts, due to putative sequencing errors.; Remark: Tan1 is identical to transposon Tndm2 from Aspergillus niger.; Remark: the Tan1 element has a unique organization: IR-ORF-IR-IR-Vader-IR.; Remark: the transposase Tan1 is present as a single copy in A. niger var. awamori.; Title: strong similarity to transposase Tan1 -Aspergillus niger [putative pseudogene]; putative pseudogene; See PMID 9003286; 2786560 84590474 An02g11380 Aspergillus niger 2784884 R 5061 CDS An02g11390 4979674 complement(join(2786863..2787129,2787202..2789349)) IV 1 NT_166519.1 Similarity: the ORF also shows strong similarity to the EST an_2371 from Aspergillus niger.; Similarity: the similarities of lower scored matches are based on repetetive structures.; Title: strong similarity to hypothetical protein encoded by DR0708 - Deinococcus radiodurans; uncharacterized protein 2789349 4979674 An02g11390 Aspergillus niger uncharacterized protein XP_001400266.1 2786863 R 5061 CDS An02g11400 4979675 join(2791747..2791812,2791879..2791968,2792034..>2797499) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein CAD70539.1 - Neurospora crassa [truncated ORF]; uncharacterized protein 2797499 4979675 An02g11400 Aspergillus niger uncharacterized protein XP_001400267.3 2791747 D 5061 CDS An02g11410 84590475 <2797602..2800583 IV 1 NT_166519.1 Remark: the A. niger ORF is N-terminally truncated due to the contig border.; Remark: the A. niger ORF shows strong similarity to EST an_3206 of A. niger.; Similarity: the ORF shows also weak similarity to the hypothetical protein PA3059 of P. aeruginosa.; Similarity: the ORF shows strong similarity to another A. niger protein. This other protein displays weak similarity to the UDP-glucose-polyglycerol phosphate glucosyltransferase tagE of B. subtilis.; Title: strong similarity to hypothetical protein encoded by An12g10440 - Aspergillus niger [truncated ORF]; uncharacterized protein 2800583 84590475 An02g11410 Aspergillus niger uncharacterized protein XP_059600086.1 2797602 D 5061 CDS An02g11420 4979677 complement(join(2801169..2801287,2801370..2801639,2801699..2804015)) IV 1 NT_166519.1 Gene-ID: dapB; Remark: the A. niger protein is unpublished.; dipeptidyl aminopeptidase type IV dapB-Aspergillus niger 2804015 dapB 4979677 dapB Aspergillus niger dipeptidyl aminopeptidase type IV dapB-Aspergillus niger XP_001400269.3 2801169 R 5061 CDS An02g11430 84590476 complement(2804781..2805854) IV 1 NT_166519.1 Remark: blastp matches are unspecific.; hypothetical protein 2805854 84590476 An02g11430 Aspergillus niger hypothetical protein XP_059600087.1 2804781 R 5061 CDS An02g11440 4979679 join(2807359..2807467,2807530..2807759,2807827..2808135,2808190..2808811,2808874..2808970,2809023..2810166,2810204..2810452) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein SPCC1450.12 - Schizosaccharomyces pombe; uncharacterized protein 2810452 4979679 An02g11440 Aspergillus niger uncharacterized protein XP_059603509.1 2807359 D 5061 CDS An02g11450 4979680 join(2810948..2811013,2811103..2812083) IV 1 NT_166519.1 hypothetical protein 2812083 4979680 An02g11450 Aspergillus niger hypothetical protein XP_059603510.1 2810948 D 5061 CDS An02g11460 4979681 join(2812541..2812835,2812899..2813000,2813053..2813130,2813180..2814141) IV 1 NT_166519.1 Pathway: N. crassa homolog met-10+ is putatively involved in methionine pathway.; Title: strong similarity to hypothetical protein met-10+ - Neurospora crassa; uncharacterized protein 2814141 4979681 An02g11460 Aspergillus niger uncharacterized protein XP_001400273.3 2812541 D 5061 CDS An02g11470 4979682 join(2814591..2814781,2814910..2815037,2815151..2815278) IV 1 NT_166519.1 Catalytic activity: nucleoside triphosphate + RNA(n) = pyrophosphate + RNA(n+1).; Localization: GFP-Rpb4 fusion protein was detected in the cytoplasm as well as the nuclei.; Remark: S. cerevisiae homolog RPB4 is essential for yeast cell growth and normal levels of RNA polymerase II activity, but not absolutely essential for mRNA synthesis.; Title: strong similarity to 16 kD subunit DNA-directed RNA polymerase II rpb4p - Schizosaccharomyces pombe; nucleus; See PMID 11168400; uncharacterized protein 2815278 4979682 An02g11470 Aspergillus niger uncharacterized protein XP_001400274.1 2814591 D 5061 CDS An02g11480 4979683 join(2818711..2819150,2819244..2820993) IV 1 NT_166519.1 Function: the Aspergillus nidulans homolog TamA functions as a co-activator of AreA, the major nitrogen regulatory protein in A. nidulans.; Localization: a GFP fusion with A. nidulans TamA is predominantly localized in the nucleus.; Remark: presence or absence of ammonium does not affect nuclear localization of GFP-TamA in A. nidulans.; Remark: the predicted DNA-binding domain of A. nidulans TamA is not essential for function.; Title: strong similarity to nitrogen regulatory protein tamA - Aspergillus nidulans; nucleus; uncharacterized protein 2820993 4979683 An02g11480 Aspergillus niger uncharacterized protein XP_001400275.1 2818711 D 5061 CDS An02g11490 84590477 complement(2821154..2821432) IV 1 NT_166519.1 Title: strong similarity to EST an_0572 -Aspergillus niger; uncharacterized protein 2821432 84590477 An02g11490 Aspergillus niger uncharacterized protein XP_059603511.1 2821154 R 5061 CDS An02g11500 84590478 complement(join(2822464..2822980,2823036..2823204,2823260..2823533,2823590..2823634)) IV 1 NT_166519.1 Remark: S. cerevisiae homolog YIL130w contains GAL4 zinc binuclear cluster domain.; Similarity: the ORF shows also similarity to probable membrane protein YIL130w of S. cerevisiae. However, the length of the ORF is only one third of the S. cerevisiae protein.; Title: weak similarity to zinc binuclear cluster protein sequence #124 from patent WO200224865-A2 -Unclassified organism; uncharacterized protein 2823634 84590478 An02g11500 Aspergillus niger uncharacterized protein XP_059603512.1 2822464 R 5061 CDS An02g11510 4979685 complement(join(2824455..2824933,2824984..2825092,2825126..2825156,2825245..2825346,2825418..2825494,2825551..2825661)) IV 1 NT_166519.1 Remark: Drosophila melanogaster RpII215 encodes the largest subunit of RNA polymerase II with a molecular weight of 215 kDa.; Title: weak similarity to largest subunit of RNA polymerase II RpII215 - Drosophila melanogaster; uncharacterized protein 2825661 4979685 An02g11510 Aspergillus niger uncharacterized protein XP_059603513.1 2824455 R 5061 CDS An02g11520 84590479 join(2825837..2826018,2826146..2826157,2826254..2826307,2826549..2826720) IV 1 NT_166519.1 hypothetical protein 2826720 84590479 An02g11520 Aspergillus niger hypothetical protein XP_059603514.1 2825837 D 5061 CDS An02g11530 4979688 join(2826918..2827211,2827268..2827741,2827807..2828088) IV 1 NT_166519.1 Remark: strong similarity to HA protein sequence SEQ ID NO:416 patent WO200100842-A2 from Corynebacterium glutamicum.; Remark: the predicted ORF is a putative hydroxyquinol-1, 2-dioxygenase by similarity.; Title: strong similarity to HA protein sequence SEQ ID NO:416 from patent WO200100842-A2 - Corynebacterium glutamicum; uncharacterized protein 2828088 4979688 An02g11530 Aspergillus niger uncharacterized protein XP_001400280.1 2826918 D 5061 CDS An02g11540 84590480 complement(join(2828555..2828685,2828840..2829038,2829134..2829205)) IV 1 NT_166519.1 hypothetical protein 2829205 84590480 An02g11540 Aspergillus niger hypothetical protein XP_059603515.1 2828555 R 5061 CDS An02g11550 4979690 2829370..2830767 IV 1 NT_166519.1 Remark: E. coli homolog b1423/YDCJ is a hypothetical protein in TRG-RIML intergenic region.; Title: strong similarity to hypothetical protein ydcJ - Escherichia coli; uncharacterized protein 2830767 4979690 An02g11550 Aspergillus niger uncharacterized protein XP_001400282.1 2829370 D 5061 CDS An02g11560 4979691 2831162..2833036 IV 1 NT_166519.1 Function: A. parasiticus homolog versicolorin B synthase (vsb) catalyzes the side chain cyclization of racemic versiconal hemiacetal to the bisfuran ring system of(-)-versicolorin B.; Pathway: Aspergillus parasiticus aflatoxin biosynthetic pathway.; Remark: A. parasiticus vsb possesses an amino-terminal sequence homologous to the ADP-binding region of other flavoenzymes. However, this enzyme does not require flavin or nicotinamide cofactors for its cyclase activity.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Title: strong similarity to versicolorin B synthase vbs - Aspergillus parasiticus; See PMID 8662689; uncharacterized protein 2833036 4979691 An02g11560 Aspergillus niger uncharacterized protein XP_001400283.1 2831162 D 5061 CDS An02g11570 4979692 complement(2833534..2834307) IV 1 NT_166519.1 Remark: S. c. homolog is a mitochondrial ribosomal protein.; Title: similarity to mitochondrial ribosomal protein of the large subunit Yml49 - Saccharomyces cerevisiae; localisation:mitochondrion; uncharacterized protein 2834307 4979692 An02g11570 Aspergillus niger uncharacterized protein XP_001400284.1 2833534 R 5061 CDS An02g11580 10098268 join(2834741..2835301,2835381..2835594) IV 1 NT_166519.1 Remark: strong similarity to Human secreted protein sequence encoded by gene 48 SEQ ID NO:188 patent WO200056754-A1.; Title: strong similarity to secreted protein sequence encoded by gene 48 SEQ ID NO:188 from patent WO200056754-A1 - Homo sapiens [putative pseudogene]; putative pseudogene; 2835594 10098268 An02g11580 Aspergillus niger 2834741 D 5061 CDS An02g11590 4979694 complement(2836916..2839306) IV 1 NT_166519.1 Function: Rps1 is required for sporulation.; Function: S. cerevisiae Rps1/Mps1 is required for spindle pole body duplication and has a mitotic checkpoint function.; Remark: alternative gene name for S. cerevisiae RPS1 is MPS1; Remark: phosphoamino acid analysis of substrates phosphorylated by Mps1p indicates that this kinase can phosphorylate serine, threonine and tyrosine residues,identifying Mps1p as a dual specificity protein kinase.; Title: strong similarity to serine/threonine protein kinase Rpk1 - Saccharomyces cerevisiae; uncharacterized protein 2839306 4979694 An02g11590 Aspergillus niger uncharacterized protein XP_001400285.3 2836916 R 5061 CDS An02g11600 84590481 join(2840861..2840883,2841306..2841492,2841558..2841637,2841880..2842033,2842264..2842284) IV 1 NT_166519.1 Remark: the ORF has an intron-exon structure, which is not typical for A. niger proteins and is only 154 amino acids long.; hypothetical protein 2842284 84590481 An02g11600 Aspergillus niger hypothetical protein XP_059603516.1 2840861 D 5061 CDS An02g11610 84590482 complement(join(2843147..2843336,2843422..2843525,2843576..2843653,2843876..2843968)) IV 1 NT_166519.1 Remark: the ORF has an intron-exon structure, which is not typical for A. niger proteins and is only 154 amino acids long.; hypothetical protein 2843968 84590482 An02g11610 Aspergillus niger hypothetical protein XP_059603517.1 2843147 R 5061 CDS An02g11620 84590483 2844301..2845665 IV 1 NT_166519.1 hypothetical protein 2845665 84590483 An02g11620 Aspergillus niger hypothetical protein XP_059603518.1 2844301 D 5061 CDS An02g11625 4979698 2846118..2847596 IV 1 NT_166519.1 Remark: similarities are based on glycin/serin rich structures.; Title: weak similarity to RNA helicase GLH-2 -Caenorhabditis elegans; uncharacterized protein 2847596 4979698 An02g11625 Aspergillus niger uncharacterized protein XP_001400289.3 2846118 D 5061 CDS An02g11627 84590484 complement(2847686..2847925) IV 1 NT_166519.1 hypothetical protein 2847925 84590484 An02g11627 Aspergillus niger hypothetical protein XP_059603519.1 2847686 R 5061 CDS An02g11630 4979700 complement(join(2850317..2850839,2850997..2851394,2851454..2851618,2851720..2851810,2851857..2851999)) IV 1 NT_166519.1 Remark: the ORF contains a PWI motif, which is often present in splicing factors suggesting it might be important for multiple interactions within splicing complexes.; Title: strong similarity to hypothetical Ser/Arg-related nuclear matrix protein - Mus musculus; uncharacterized protein 2851999 4979700 An02g11630 Aspergillus niger uncharacterized protein XP_059603520.1 2850317 R 5061 CDS An02g11640 84590485 join(2853923..2853979,2854071..2854349) IV 1 NT_166519.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght of only 111 amino acids.; Title: questionable ORF; uncharacterized protein 2854349 84590485 An02g11640 Aspergillus niger uncharacterized protein XP_059603521.1 2853923 D 5061 CDS An02g11650 4979702 complement(join(2855646..2855664,2855713..2855804,2855848..2856081,2856227..2856274)) IV 1 NT_166519.1 Remark: the first intron is unusually long.; hypothetical protein 2856274 4979702 An02g11650 Aspergillus niger hypothetical protein XP_001400293.3 2855646 R 5061 CDS An02g11660 4979703 join(2856881..2857178,2857269..2857696) IV 1 NT_166519.1 Similarity: the ORF shows strong similarity to several putative 2-hydroxyhepta-2,4-diene-1,7-dioate isomerases from bacteria.; Title: strong similarity to hypothetical homolog of prokaryotic 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase SPBC21C3.09c - Schizosaccharomyces pombe; uncharacterized protein 2857696 4979703 An02g11660 Aspergillus niger uncharacterized protein XP_059603522.1 2856881 D 5061 CDS An02g11670 4979704 complement(join(2857952..2857985,2858032..2858840)) IV 1 NT_166519.1 hypothetical protein 2858840 4979704 An02g11670 Aspergillus niger hypothetical protein XP_059603523.1 2857952 R 5061 CDS An02g11680 4979705 complement(join(2859580..2859590,2859652..2860294,2860355..2860713,2860772..2860840,2860907..2860981,2861183..2861222)) IV 1 NT_166519.1 Function: eIF-4A of S. pombe recognizes and binds to the 7-methylguanosine-containing (m7Gppp) cap during an early step in the initiation of protein synthesis and facilitates ribosome binding to a mRNA by inducing the unwinding of its secondary structures.; Remark: eIF-4A of S. pombe is also called mRNA CAP-binding protein, eIF-4F 25 kDA subunit, TIF451, TIF45,TIF1 or SPAC16E8. 15.; Title: strong similarity to translation initiation factor eIF-4A - Schizosaccharomyces pombe; uncharacterized protein 2861222 4979705 An02g11680 Aspergillus niger uncharacterized protein XP_001400296.1 2859580 R 5061 CDS An02g11690 4979706 join(2862017..2862351,2862519..2863707) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein F3F9.18 - Arabidopsis thaliana; uncharacterized protein 2863707 4979706 An02g11690 Aspergillus niger uncharacterized protein XP_001400297.1 2862017 D 5061 CDS An02g11700 4979707 complement(join(2863877..2863994,2864059..2864149,2864381..2864579,2864712..2864801)) IV 1 NT_166519.1 Phenotype: CTR2 overexpression in S. pombe provides increased resistance to copper starvation and is also associated with an increased sensitivity to copper toxicity.; Phenotype: S. pombe ctr2 mutants display a high level of resistance to toxic copper concentrations.; Similarity: the ORF overlaps with A. niger ESTs an_0415 (EMBLEST:BE760746), an_3561 (EMBLEST:BE759211) and entry PATENTDNA:AAF11529 SEQ ID NO:4052.; Title: strong similarity to copper transport protein Ctr2 - Saccharomyces cerevisiae; See PMID 7499355; uncharacterized protein 2864801 4979707 An02g11700 Aspergillus niger uncharacterized protein XP_001400298.1 2863877 R 5061 CDS An02g11710 84590486 join(2865641..2865730,2865834..2866085) IV 1 NT_166519.1 Remark: the ORF has an intron-exon structure, which is not typical for A. niger proteins and is only 113 amino acids long.; hypothetical protein 2866085 84590486 An02g11710 Aspergillus niger hypothetical protein XP_059600088.1 2865641 D 5061 CDS An02g11720 4979709 complement(join(2866366..2866987,2867036..2869028,2869122..2869630,2869721..2869866)) IV 1 NT_166519.1 Function: alpha-mannosidases facilitate the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides, which originate from N-linked carbohydrate chains released during glycoprotein turnover.; Title: strong similarity to alpha-mannosidase msd2 -Aspergillus nidulans; uncharacterized protein 2869866 4979709 An02g11720 Aspergillus niger uncharacterized protein XP_001400300.1 2866366 R 5061 CDS An02g11730 84590487 join(2870055..2870102,2870233..2870598) IV 1 NT_166519.1 Remark: the ORF has an intron-exon structure, which is not typical for A. niger proteins and is only 137 amino acids long.; Title: questionable ORF; uncharacterized protein 2870598 84590487 An02g11730 Aspergillus niger uncharacterized protein XP_059600089.1 2870055 D 5061 CDS An02g11740 84590488 complement(join(2871542..2871686,2871794..2871846)) IV 1 NT_166519.1 Remark: the ORF has an intron-exon structure, which is not typical for A. niger proteins and is only 65 amino acids l; Title: questionable ORF; uncharacterized protein 2871846 84590488 An02g11740 Aspergillus niger uncharacterized protein XP_059600090.1 2871542 R 5061 CDS An02g11750 4979712 join(2872086..2872752,2872832..2873139) IV 1 NT_166519.1 Similarity: the ORF overlaps with A. niger ESTs an_2297 (EMBLEST:BE759480), an_2292 (EMBLEST:BE759475) and an_2887 (EMBLEST:BE759941).; Title: strong similarity to hypothetical conserved protein SPBC337.10c - Schizosaccharomyces pombe; uncharacterized protein 2873139 4979712 An02g11750 Aspergillus niger uncharacterized protein XP_001400303.1 2872086 D 5061 CDS An02g11760 4979713 complement(2874593..2875984) IV 1 NT_166519.1 Remark: the A. niger EST is decribed in PATENTDNA:AAF11691 EST SEQ ID NO:4214.; Title: strong similarity to EST SEQ ID NO:4214 from patent WO200056762-A2 - Aspergillus niger; uncharacterized protein 2875984 4979713 An02g11760 Aspergillus niger uncharacterized protein XP_001400304.1 2874593 R 5061 CDS An02g11770 84590489 join(2876981..2877052,2877144..2877338) IV 1 NT_166519.1 Remark: the ORF has an intron-exon structure, which is not typical for A. niger proteins and is only 88 amino acids long.; Title: questionable ORF; uncharacterized protein 2877338 84590489 An02g11770 Aspergillus niger uncharacterized protein XP_059600091.1 2876981 D 5061 CDS An02g11780 84590490 complement(join(2879290..2879357,2879446..2879598,2879786..2879826,2879933..2880004,2880065..2880147)) IV 1 NT_166519.1 Remark: the intron-exon structure of the ORF is not typical for A. niger proteins.; hypothetical protein 2880147 84590490 An02g11780 Aspergillus niger hypothetical protein XP_059600092.1 2879290 R 5061 CDS An02g11790 4979716 complement(join(2880654..2880982,2881072..2881501)) IV 1 NT_166519.1 Function: pcd1 of S. cerevisiae is a putative peroxisomal nudix hydrolase active towards coenzyme A and its derivatives.; Remark: in constrast to pcd1 of S. cerevisiae, no membrane region was predicted in the ORF.; Title: similarity to hypothetical coenzyme A diphosphatase Pcd1 - Saccharomyces cerevisiae; uncharacterized protein 2881501 4979716 An02g11790 Aspergillus niger uncharacterized protein XP_001400307.3 2880654 R 5061 CDS An02g11800 4979717 complement(join(2882922..2883971,2884034..2884606,2884647..2884673)) IV 1 NT_166519.1 Function: YPR125w of S. cerevisiae supresses the splicing defect caused by the disruption of the nuclear MRS2 gene (mrs2-1 mutation), which causes a strong pet-phenotype in strains with mitochondrial group II introns, and a leaky pet-phenotype in strains without group II introns.; Title: strong similarity to hypothetical membrane protein YPR125w - Saccharomyces cerevisiae; uncharacterized protein 2884673 4979717 An02g11800 Aspergillus niger uncharacterized protein XP_059600093.1 2882922 R 5061 CDS An02g11810 4979718 complement(join(2885361..2886099,2886152..2887068)) IV 1 NT_166519.1 Title: strong similarity to hypothetical conserved protein 12F11.50 - Neurospora crassa; uncharacterized protein 2887068 4979718 An02g11810 Aspergillus niger uncharacterized protein XP_001400309.3 2885361 R 5061 CDS An02g11820 84590491 complement(join(<2890369..2890930,2891013..2891120)) IV 1 NT_166519.1 Catalytic activity: phaB of A. latus converts (R)-3-hydroxyacyl-CoA + NADP(+) <=> 3-oxoacyl-CoA + NADPH.; Function: phaB of A. latus is involved in the metabolism of butanoate.; Remark: a puative frameshift due to a possible sequencing error at position 609 (one base too much) was corrected.; Title: strong similarity to acetoacetyl-CoA reductase phaB - Alcaligenes latus [putative frameshift]; putative frameshift; uncharacterized protein 2891120 84590491 An02g11820 Aspergillus niger uncharacterized protein XP_059606031.1 2890369 R 5061 CDS An02g11830 4979720 complement(2891277..2891975) IV 1 NT_166519.1 Catalytic activity: glutathione S-transferases convert RX + glutathione <=> HX + R-S-glutathione.; Function: URE2 of S. cerevisiae is involved in cellular responses to the nitrogen source.; Phenotype: disruption of URE2 in S. cerevisiae showed that URE2 is regulating GLN1 and GDH2, the structural genes for glutamine synthetase and NAD-linked glutamate dehydrogenase, respectively, at the transcriptional level.; Title: strong similarity to glutathione transferase homolog Ure2 - Saccharomyces cerevisiae; uncharacterized protein 2891975 4979720 An02g11830 Aspergillus niger uncharacterized protein XP_001400311.1 2891277 R 5061 CDS An02g11840 84590492 complement(join(2892181..2892271,2892548..2892633,2892678..2892752,2892867..2893153,2893272..2893338)) IV 1 NT_166519.1 hypothetical protein 2893338 84590492 An02g11840 Aspergillus niger hypothetical protein XP_059606032.1 2892181 R 5061 CDS An02g11850 84590493 join(2893949..2894005,2894252..2894266,2894408..2894549,2894813..2894883) IV 1 NT_166519.1 Remark: the ORF has an intron-exon structure, which is not typical for A. niger proteins and is only 94 amino acids long.; Title: questionable ORF; uncharacterized protein 2894883 84590493 An02g11850 Aspergillus niger uncharacterized protein XP_059606033.1 2893949 D 5061 CDS An02g11860 4979723 complement(join(2895379..2895953,2896027..2896212,2896287..2896737)) IV 1 NT_166519.1 Title: strong similarity to hypothetical Ydr124wp-like protein - Pneumocystis carinii; uncharacterized protein 2896737 4979723 An02g11860 Aspergillus niger uncharacterized protein XP_001400314.3 2895379 R 5061 CDS An02g11870 84590494 complement(join(2898187..2898359,2898560..2898701)) IV 1 NT_166519.1 Remark: the ORF has an intron-exon structure, which is not typical for A. niger proteins and is only 104 amino acids long.; Title: questionable ORF; uncharacterized protein 2898701 84590494 An02g11870 Aspergillus niger uncharacterized protein XP_059606034.1 2898187 R 5061 CDS An02g11880 84590495 join(2898939..2899140,2899418..2899570,2899659..2899724,2900160..2900341) IV 1 NT_166519.1 Remark: the ORF has an intron-exon structure, which is not typical for A. niger proteins.; Title: questionable ORF; uncharacterized protein 2900341 84590495 An02g11880 Aspergillus niger uncharacterized protein XP_059606035.1 2898939 D 5061 CDS An02g11890 4979726 complement(join(2900589..2901396,2901506..2902021,2902110..2902209,2902354..2902555)) IV 1 NT_166519.1 Similarity: the ORF shows also weak similarity to heparanase Hep of R. norvegicus and of H. sapiens.; Title: strong similarity to hypothetical protein encoded by An14g01330 - Aspergillus niger; uncharacterized protein 2902555 4979726 An02g11890 Aspergillus niger uncharacterized protein XP_001400317.1 2900589 R 5061 CDS An02g11900 4979727 complement(join(<2904290..2904737,2904795..2905102,2905152..2907945,2908042..2908126,2908204..2908297,2908350..2908380)) IV 1 NT_166519.1 Function: SMC1 of S. cerevisiae is a coiled-coil protein involved in chromosome structure or segregation,which is essential for yeast nuclear division.; Phenotype: smc1p-depleted S. cerevisiae cells have a defect in nuclear division as evidenced by the absence of anaphase cells.; Phenotype: the smc1-1 mutant of S. cerevisiae was identified initially as a mutant of S. cerevisiae that had an elevated rate of minichromosome nondisjunction.; Remark: SMC1 of S. cerevisiae is also called chl10 or YFL008W.; Remark: a putative sequencing error in the fourth exon results in an frameshift.; Title: strong similarity to chromosome segregation protein Smc1 - Saccharomyces cerevisiae [putative frameshift]; putative frameshift; See PMID 7929577; See PMID 8442383; uncharacterized protein 2908380 4979727 An02g11900 Aspergillus niger uncharacterized protein XP_059606036.1 2904290 R 5061 CDS An02g11910 4979728 join(2910290..2910368,2910497..2911287) IV 1 NT_166519.1 Function: pdx1 of S. cerevisiae plays a structural role in the PDH complex, i. e., it binds and positions E3 (dihydrolipoamide dehydrogenase) to the E2 (dihydrolipoamide transactylase) core, and this specific binding is essential for a functional PDH complex.; Phenotype: mitochondrial extracts of S. cerevisiae pdx1 minus mutants do not catalyze a CoA- and NAD(+)-linked oxidation of pyruvate.; Remark: pdx1 of S. cerevisiae is also called dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex, E3-binding protein or E3BP.; Title: similarity to mitochondrial pyruvate dehydrogenase complex protein Pdx1 - Saccharomyces cerevisiae; uncharacterized protein 2911287 4979728 An02g11910 Aspergillus niger uncharacterized protein XP_001400319.1 2910290 D 5061 CDS An02g11920 4979729 complement(join(2912457..2913221,2913275..2913821,2913905..2914048,2914154..2914482)) IV 1 NT_166519.1 Function: Fzr1 of M. musculus is a recently identified 7WD domain member of a family, which is implicated in cell cycle regulation of Drosophila and yeast.; Function: overexpression of Fzr1 of M. musculus increases natural killer cell-mediated cell death and suppresses tumor growth.; Remark: Fzr1 of M. musculus is also called Fyr or fzr.; Remark: mammalian fizzy-related genes regulate the cyclosome. Ubiquitin-mediated proteolysis by the cyclosome plays an essential role in cell cycle control.; Similarity: the ORF shows strong similarity to the A. niger EST an_2748.; Title: strong similarity to fizzy-related protein Fzr1 - Mus musculus; See PMID 10606752; See PMID 10891459; uncharacterized protein 2914482 4979729 An02g11920 Aspergillus niger uncharacterized protein XP_059606037.1 2912457 R 5061 CDS An02g11930 84590496 complement(join(2915153..2915290,2915374..2915514)) IV 1 NT_166519.1 hypothetical protein 2915514 84590496 An02g11930 Aspergillus niger hypothetical protein XP_059606038.1 2915153 R 5061 CDS An02g11940 4979731 join(2916376..2916451,2916509..2916570,2916623..2916724,2916784..2916919,2916971..2917063,2917113..2918137) IV 1 NT_166519.1 Title: strong similarity to aminopeptidase METPRO02 from patent EP939131-A2 - Homo sapiens; uncharacterized protein 2918137 4979731 An02g11940 Aspergillus niger uncharacterized protein XP_001400322.1 2916376 D 5061 CDS An02g11950 4979732 join(2918548..2918759,2918866..2919628) IV 1 NT_166519.1 Title: similarity to hypothetical protein SPAC4D7.11 - Schizosaccharomyces pombe; uncharacterized protein 2919628 4979732 An02g11950 Aspergillus niger uncharacterized protein XP_001400323.1 2918548 D 5061 CDS An02g11960 4979733 complement(join(2919848..2920399,2920454..2920479,2920546..2920564,2920627..2920785)) IV 1 NT_166519.1 Complex: E. coli clpP is the proteolytic component of clp proteinase. The Clp holoenzyme consists of two adjacent heptameric rings of the proteolytic subunit ClpP,which are flanked by a hexameric ring of a regulatory subunit from the Clp/Hsp100 chaperone family at one or both ends.; Function: the E. coli homolog clpP encodes a protease required for ATP-driven cleavage of proteins to small peptides; Remark: electron micrographs of the protein show superimposed disk-like structures with a central cavity,similar in appearance to purified proteasomes from eukaryotic cells.; Remark: the proposed function of the ClpX/ClpP complex in eukaryotic mitochondria is to exhert functions similar to the proteasome in this subcellular compartment.; Title: strong similarity to endopeptidase Clp chain P clpP - Escherichia coli; uncharacterized protein 2920785 4979733 An02g11960 Aspergillus niger uncharacterized protein XP_001400324.1 2919848 R 5061 CDS An02g11970 4979734 complement(join(<2922542..2923058,2923129..2923220,2923279..2923347,2923422..2923443,2923526..>2923630)) IV 1 NT_166519.1 Function: pho13 of S. pombe and aryl phosphatases functions as a phosphoric monoester hydrolase.; Remark: pho13 of S. pombe is also called PHO13 or SPBC15D4. 15.; Similarity: the predicted ORF shows similarity to nitrophenylphosphatases and acryl phosphatases from different species.; Title: strong similarity to 4-nitrophenylphosphatase pho13p - Schizosaccharomyces pombe; cytoplasm; uncharacterized protein 2923630 4979734 An02g11970 Aspergillus niger uncharacterized protein XP_001400325.3 2922542 R 5061 CDS An02g11980 4979735 complement(join(2924199..2924363,2924412..2925215,2925275..2925361,2925418..2925528)) IV 1 NT_166519.1 Function: rfc is a DNA binding protein and ATPase that acts as a processivity factor for DNA polymerases delta and epsilon and loads proliferating cell nuclear antigen (PCNA) on DNA.; Function: rfc2 of S. cerevisiae interacts with the CDC44/RFC1 and RFC5 gene products in the RF-C complex and with both DNA polymerases during chromosomal DNA replication.; Phenotype: disruption of the rcf2 gene in S. cerevisiae led to a dumbbell-shaped terminal morphology,common to mutants having a defect in chromosomal DNA replication.; Phenotype: mutant rcf2 in S. cerevisiae courses temperature-sensitive cell growth, defects in the integrity of chromosomal DNA at restrictive temperatures,progression through cell cycle without definitive terminal morphology and rapid loss of cell viability at restrictive temperatures, sensitivity to hydroxyurea, methyl methanesulfonate and UV light and an increased rate of spontaneous mitotic recombination and chromosome loss.; Remark: replication factor C is also called activator 1.; Title: strong similarity to replication factor C chain Rfc2 - Saccharomyces cerevisiae; nucleus; See PMID 9671499; uncharacterized protein 2925528 4979735 An02g11980 Aspergillus niger uncharacterized protein XP_059606039.1 2924199 R 5061 CDS An02g11990 4979736 complement(join(2925812..2926365,2926436..2926716,2926783..2927096)) IV 1 NT_166519.1 Function: sec20 of C. albicans is probably involved in vesicle formation for retrograde golgi-ER protein transport.; Phenotype: reduced sec20 expression in the C. albicans PCK1p-SEC20 strain is not affecting morphogenesis but leads to a series of hypersensitivity phenotypes including supersensitivity to aminoglycoside antibiotics,to nystatin, to sodium dodecyl sulfate, and to cell wall inhibitors.; Phenotype: repression of sec20 expression in C. albicans prevented (MET3p-SEC20 allele) or retarded (PCK1p-SEC20 allele) growth and led to the appearance of extensive intracellular membranes, which frequently formed stacks.; Remark: the predicted ORF contains an C-terminal ER retention signal (KDEL), which is homologues to the yeast retention signal HDEL found in sec20 of S. cerevisae and unusual for a membrane protein.; Similarity: the similarity of the predicted ORF to sec20 of C. albicans is restricted to the inner part of the ORF, reaching from amino acid 50 to 280.; Title: similarity to protein involved in protein secretion sec20 - Candida albicans; See PMID 1537327; See PMID 11114899; uncharacterized protein 2927096 4979736 An02g11990 Aspergillus niger uncharacterized protein XP_059606040.1 2925812 R 5061 CDS An02g12000 4979737 join(2927280..2927357,2927532..2927595,2927645..2927986,2928320..2928363) IV 1 NT_166519.1 Remark: the predicted intron-exon structure of the ORF and its lenght are suboptimal.; Similarity: the predicted ORF shows weak similarity to a short stretch (73 bp) of the A. nidulans ESTEMBLEST:AI213526.; Title: similarity to ribosomal protein YmL44-like protein CAE76322.1 - Neurospora crassa; uncharacterized protein 2928363 4979737 An02g12000 Aspergillus niger uncharacterized protein XP_001400328.3 2927280 D 5061 CDS An02g12010 4979738 complement(join(2928488..2928626,2928679..2928762,2928817..2929160,2929220..2929339,2929434..2929610)) IV 1 NT_166519.1 Catalytic activity: ipp1 of S. cerevisiae converts pyrophosphat + H(2)O = 2 orthophosphate.; Function: ipp1 of S. cerevisiae catalyzes the hydrolysis of pyrophosphate to orthophosphate.; Induction: for the activation of ipp1 from S. cerevisiae the presence of a divalent metal cation is necessary, magnesium confers the highest activity.; Remark: inorganic pyrophosphatases can be active in cytosol or mitochiondrium.; Remark: ipp1 of S. cerevisiae is also called PPA1,PPA, YBR011C, YBR011 or YBR0202.; Similarity: the predicted ORF shows similarity to several inorganic pyrophosphatases from different species.; Title: strong similarity to inorganic pyrophosphatase Ipp1 - Saccharomyces cerevisiae; uncharacterized protein 2929610 4979738 An02g12010 Aspergillus niger uncharacterized protein XP_001400329.3 2928488 R 5061 CDS An02g12020 84590497 complement(join(2930178..2930524,2930562..2930568)) IV 1 NT_166519.1 hypothetical protein 2930568 84590497 An02g12020 Aspergillus niger hypothetical protein XP_059600094.1 2930178 R 5061 CDS An02g12030 4979740 2931247..2932587 IV 1 NT_166519.1 Function: smm1 of S. cerevisiae is involved in the synthesis and processing of mitochondrial tRNAs.; Phenotype: overexpression of smm1 in S . cerevisiae weakly suppresses a mutation affecting the maturation of mitochondrial tRNA-Asp.; Phenotype: the smm1 mutation in S. cerevisiae cells confers temperature-sensitiv growth and aberrant mitochondrial inheritance and morphology at the nonpermissive temperature.; Remark: smm1 of S. cerevisiae is also called YNR015W or N2065.; Similarity: the similarity to smm1 of S. cerevisiae is restricted to its N-terminal part, reaching to amino acid 300.; Title: strong similarity to hypothetical tRNA--dihydrouridine synthase Smm1 - Saccharomyces cerevisiae; See PMID 9211792; See PMID 10366593; uncharacterized protein 2932587 4979740 An02g12030 Aspergillus niger uncharacterized protein XP_001400331.3 2931247 D 5061 CDS An02g12040 4979741 complement(2933512..2936883) IV 1 NT_166519.1 Phenotype: disruption of the fun30 gene in S. cerevisiae surprisingly resulted in increased resistance to UV irradiation.; Remark: synonyms for fun30 of S. cerevisiae are YAL019W or YAL001.; Similarity: the predicted ORF shows strong similarity to several helicases from different species.; Title: strong similarity to helicase Fun30 -Saccharomyces cerevisiae; nucleus; See PMID 10454593; See PMID 8144453; uncharacterized protein 2936883 4979741 An02g12040 Aspergillus niger uncharacterized protein XP_001400332.1 2933512 R 5061 CDS An02g12050 4979742 join(2937836..2937911,2937978..2938114) IV 1 NT_166519.1 Function: Vma21p of S. cerevisiae is involved in vacuolar H-ATPase assembly or function, which is important for vacuolar acidification.; Phenotype: null mutants of vma21 cannot grow on glycerol or at pH 7. 5 and exhibits increased calcium sensitivity.; Remark: the systematic name for VMA21 is YGR105W.; Title: similarity to V-ATPase assembly protein Vma21 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 10600674; See PMID 7841520; See PMID 8416931; uncharacterized protein 2938114 4979742 An02g12050 Aspergillus niger uncharacterized protein XP_001400333.3 2937836 D 5061 CDS An02g12060 4979743 complement(join(2938617..2939051,2939136..2939240)) IV 1 NT_166519.1 Catalytic activity: cystathione beta-synthases convert L-serine + L-homocysteine <=> cystathionine + H(2)O.; Function: cystathione beta-synthases have sulfhydrase and beta-thionase activity and catalyzs the first irreversible step in homocysteine transulfuration.; Induction: cystathione beta-synthase are pyridoxal-phosphate dependent.; Similarity: the ORF shows similarity to the C-terminal end of cysB from D. discoideum including the characteristic CBS domain.; Title: similarity to hypothetical cystathione beta-synthase cysB - Dictyostelium discoideum; uncharacterized protein 2939240 4979743 An02g12060 Aspergillus niger uncharacterized protein XP_001400334.1 2938617 R 5061 CDS An02g12070 4979744 join(2939911..2940195,2940270..2940434,2940484..2940737,2940788..2941133,2941189..2941208,2941271..2941340) IV 1 NT_166519.1 Repression: the activity of phosphate transporters can be inhibited by N-ethylmaleimide.; Similarity: the predicted ORF shows strong similarity to several mitochondrial phosphate transporters; Title: strong similarity to mitochondrial phosphate transport protein G7 - Glycine max; localisation:mitochondrion; See PMID 10437831; uncharacterized protein 2941340 4979744 An02g12070 Aspergillus niger uncharacterized protein XP_001400335.1 2939911 D 5061 CDS An02g12080 4979745 join(2942157..2942196,2942292..2942322,2942381..2942450,2942552..2942674,2942754..2942885) IV 1 NT_166519.1 Similarity: the ORF shows similarity to several glycine-rich proteins.; Similarity: the predicted ORF overlaps with A. niger EST EMBLEST:BE759579.; hypothetical protein 2942885 4979745 An02g12080 Aspergillus niger hypothetical protein XP_001400336.1 2942157 D 5061 CDS An02g12090 4979746 complement(join(2943548..2944158,2944379..2944501,2944627..2944656,2944815..2945010)) IV 1 NT_166519.1 Similarity: the predicted ORF shows similarity to several glutamic acid-rich proteins due to its high glutamic acid content.; Similarity: the similarity to the other A. niger protein, however, is short (about 60 amino acids) but highly specific.; Title: weak similarity to hypothetical protein encoded by An03g06210 - Aspergillus niger; uncharacterized protein 2945010 4979746 An02g12090 Aspergillus niger uncharacterized protein XP_059600095.1 2943548 R 5061 CDS An02g12100 84590498 join(2945346..2945521,2945652..2945766) IV 1 NT_166519.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF; uncharacterized protein 2945766 84590498 An02g12100 Aspergillus niger uncharacterized protein XP_059600096.1 2945346 D 5061 CDS An02g12110 84590499 complement(join(2945809..2946132,2946236..2946313,2946441..2946482,2946619..2946691,2946971..2947019,2947097..2947172,2947234..2947294,2947406..2947467,2947629..2947790)) IV 1 NT_166519.1 hypothetical protein 2947790 84590499 An02g12110 Aspergillus niger hypothetical protein XP_059600097.1 2945809 R 5061 CDS An02g12120 4979749 complement(join(2950057..2950154,2950267..2950367,2950434..2950475,2950541..2950594,2950747..2950756,2950901..2950925)) IV 1 NT_166519.1 Remark: rpl37B of S. cerevisiae is also called YOR234C, RPL35B, YDR500C or D9719. 6.; Remark: there are two genes for rpl37 in S. cerevisiae rpl37A and rp37B with only one conservative amino acid difference.; Similarity: the predicted ORF overlaps with A. niger ESTs EMBLEST:BE759376, EMBLEST:BE759740 and PATENTDNA:AAF11451 EST SEQ ID NO:3974.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit Rpl37b - Saccharomyces cerevisiae; cytoplasm; See PMID 8082197; 60S ribosomal protein eL33 2950925 4979749 An02g12120 Aspergillus niger 60S ribosomal protein eL33 XP_001400340.1 2950057 R 5061 CDS An02g12130 84590500 join(2951796..2951823,2951950..2952152,2952305..2952583) IV 1 NT_166519.1 Remark: the sequence overlaps with A. niger EST EMBL:ANNGSDA (A. niger gsdA gene).; Title: questionable ORF; uncharacterized protein 2952583 84590500 An02g12130 Aspergillus niger uncharacterized protein XP_059600098.1 2951796 D 5061 CDS An02g12140 4979751 join(2953468..2953511,2953863..2953935,2953991..2954011,2954078..2954422,2954496..2954693,2954759..2954843,2954902..2954978,2955031..2955238,2955295..2955666,2955722..2955831) IV 1 NT_166519.1 Catalytic activity: gsdA of A. niger converts glucose-6-phosphate + NADP(+) = D-glucono-delta-lactone 6-phosphate + NADPH.; Function: gsdA of A. niger catalyses the first step in the pentose phosphate pathway.; Gene-ID: gsdA; Phenotype: overexpression of gsdA in A. niger was shown to be deleterious for the fungus, especially when cotransformants were grown on media containing ammonia.; Remark: the predicted ORF overlaps with A. niger ESTs EMBLEST:BE760650, EMBL:ANG6PDHSE (A. niger mRNA for glucose-6-phosphate dehydrogenase) and EMBL:ANNGSDA (A. niger gsdA gene).; Repression: glucose-6-phosphat 1-dehydrogenase is inhibited by NADPH and stimulated by NADP(+).; cytoplasm; glucose-6-phosphat 1-dehydrogenase gsdA-Aspergillus niger 2955831 gsdA 4979751 gsdA Aspergillus niger glucose-6-phosphat 1-dehydrogenase gsdA-Aspergillus niger XP_001400342.1 2953468 D 5061 CDS An02g12150 84590501 complement(join(2956040..2956145,2956239..2956463,2956542..2956663)) IV 1 NT_166519.1 Similarity: the sequence probably contains a putative duplication fragment of the 3' ORF, as it overlaps with a part of the A. niger gsdA gene sequence (EMBL:ANNGSDA).; Title: questionable ORF; uncharacterized protein 2956663 84590501 An02g12150 Aspergillus niger uncharacterized protein XP_059600099.1 2956040 R 5061 CDS An02g12160 4979753 join(2956879..2956976,2957092..2957117,2957174..2957418,2957493..2957559,2957613..2957684,2957736..2957925,2957986..2958101,2958168..2959066) IV 1 NT_166519.1 Function: suc1 of P. major catalyzes the active uptake of sucrose or maltose and is sensitive to uncouplers.; Similarity: the ORF shows similarity to several sucrose transporters from different species.; Title: strong similarity to sucrose transport protein suc1 - Plantago major; uncharacterized protein 2959066 4979753 An02g12160 Aspergillus niger uncharacterized protein XP_001400344.1 2956879 D 5061 CDS An02g12170 4979754 complement(join(2960280..2960359,2960425..2962721,2962790..2963018,2963068..2963161,2963242..2963399,2963515..2963704)) IV 1 NT_166519.1 Function: msb1 of S. cerevisiae is involved in the establishment of cell polarity and bud formation.; Remark: msb1 of S. cerevisiae is also called YOR188W.; Similarity: the ORF shows similarity to some nucleolus-cytoplasm shuttle phosphoproteins.; Similarity: the similarity of the predicted ORF to msb1 from S. crevisiae is restricted to its N-terminal end,ending with amino acid 350.; Title: strong similarity to morphogenesis-related protein Msb1 - Saccharomyces cerevisiae; See PMID 2690082; uncharacterized protein 2963704 4979754 An02g12170 Aspergillus niger uncharacterized protein XP_001400345.1 2960280 R 5061 CDS An02g12180 84590502 join(2963783..2963797,2963883..2964015,2964118..2964250,2964353..2964452) IV 1 NT_166519.1 hypothetical protein 2964452 84590502 An02g12180 Aspergillus niger hypothetical protein XP_059600100.1 2963783 D 5061 CDS An02g12190 84590503 join(2965299..2965460,2965841..2965939) IV 1 NT_166519.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF; uncharacterized protein 2965939 84590503 An02g12190 Aspergillus niger uncharacterized protein XP_059600101.1 2965299 D 5061 CDS An02g12200 84590504 complement(join(2966092..2966157,2966258..2966312,2966392..2966439,2966516..2966580)) IV 1 NT_166519.1 hypothetical protein 2966580 84590504 An02g12200 Aspergillus niger hypothetical protein XP_059600102.1 2966092 R 5061 CDS An02g12210 4979758 join(2966683..2966738,2966821..2966977,2967053..2968714) IV 1 NT_166519.1 Function: mef2a of H. sapiens is a transcription factor involved in cell proliferation and differentiation,which binds to conserved A/T-rich sequence in the control regions of numerous muscle-specific genes.; Remark: mef2a is also called mf2A.; Similarity: due to its high proline content, the predicted ORF shows similarity to several hydroxyproline-rich proteins.; Similarity: the similarity of the predicted ORF to mef2A from H. sapiens is locally high in its N-terminal part, reaching from amino acid 1 to 430 and including all characteristic motivs of the transcription factor.; Title: strong similarity to myocyte-specific enhancer factor mef2A - Homo sapiens; nucleus; See PMID 8114702; See PMID 8148875; uncharacterized protein 2968714 4979758 An02g12210 Aspergillus niger uncharacterized protein XP_001400349.1 2966683 D 5061 CDS An02g12220 4979759 complement(join(2970036..2971150,2971208..2971329,2971386..2971696,2971851..2972153)) IV 1 NT_166519.1 Function: multidrug transporter are active in the efflux of a varity of (often cytotoxic) compounds, e. g. fnx1 of S. pombe possibly releases a signaling substance into the environment, which could be required for entry of the cell into the quiescent G0 state.; Remark: the poly-A end of the predicted ORF overlaps with A. niger ESTs EMBLEST:BE760322 and EMBLEST:BE760339.; Similarity: the ORF shows strong similarity to several multi drug resistance transporters with different specificity.; Title: strong similarity to multidrug resistance protein fnx1p - Schizosaccharomyces pombe; uncharacterized protein 2972153 4979759 An02g12220 Aspergillus niger uncharacterized protein XP_059600103.1 2970036 R 5061 CDS An02g12230 4979760 complement(join(2973199..2974131,2974212..2974230,2974303..2974343)) IV 1 NT_166519.1 Similarity: the ORF is similar to the region of homologues protein, where the calcium-binding domain (EF-hand) is located.; Similarity: the predicted ORF shows similarity to several calcium-binding proteins with different functions,like calpain-related proteins.; Title: strong similarity to calcium-binding protein abp32 - Homo sapiens; uncharacterized protein 2974343 4979760 An02g12230 Aspergillus niger uncharacterized protein XP_059600104.1 2973199 R 5061 CDS An02g12240 84590505 join(2974482..2974502,2974592..2974780,2974872..2974961) IV 1 NT_166519.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght of only 99 amino acids.; Title: questionable ORF; uncharacterized protein 2974961 84590505 An02g12240 Aspergillus niger uncharacterized protein XP_059600105.1 2974482 D 5061 CDS An02g12250 4979762 complement(join(2975060..2975183,2975250..2976130)) IV 1 NT_166519.1 Function: the short-chain dehydrogenase family is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases.; Similarity: the predicted ORF shows similarity to several proteins, which are members of the short-chain dehydrogenase/reductase superfamily (SDR).; Title: strong similarity to alcohol dehydrogenase pan2 - Mus musculus; uncharacterized protein 2976130 4979762 An02g12250 Aspergillus niger uncharacterized protein XP_001400353.1 2975060 R 5061 CDS An02g12260 4979763 join(2977040..2977109,2977319..2977368,2977474..2977478,2977553..2977637,2977721..2978254) IV 1 NT_166519.1 Remark: the predicted intron-exon structure of the ORF is unusual.; Similarity: the similarity of the ORF to the hypothetical protein SPBC31F10. 03 of S. pombe is restricted to the inner part of the molecules, reaching from amino acids 24 to 200.; Title: strong similarity to hypothetical protein SPBC31F10.03 - Schizosaccharomyces pombe; uncharacterized protein 2978254 4979763 An02g12260 Aspergillus niger uncharacterized protein XP_059600106.1 2977040 D 5061 CDS An02g12270 4979764 complement(join(2978766..2978806,2978881..2978990,2979040..2979146,2979215..2979287,2979350..2979369)) IV 1 NT_166519.1 Induction: the transcript of grrbp2 of E. esula is induced in response to low temperatures.; Similarity: the ORF shows similarity to several RNA-binding proteins with glycine-rich domains.; Similarity: the predicted ORF overlaps with A. niger ESTs EMBLEST:BE759828 and PATENTDNA:AAF11490 SEQ ID NO:4013.; Title: strong similarity to glycine-rich RNA-binding protein grrbp2 - Euphorbia esula; See PMID 9747799; See PMID 10858526; uncharacterized protein 2979369 4979764 An02g12270 Aspergillus niger uncharacterized protein XP_001400355.1 2978766 R 5061 CDS An02g12280 84590506 join(2980045..2980079,2980188..2980429,2980499..2980559,2980681..2980727,2980849..2980920,2981074..2981336) IV 1 NT_166519.1 hypothetical protein 2981336 84590506 An02g12280 Aspergillus niger hypothetical protein XP_059600107.1 2980045 D 5061 CDS An02g12290 84590507 join(2982295..2982424,2982486..2982946,2982998..2984473) IV 1 NT_166519.1 Function: sf1 contributes to the recognition of the 3' splice site by interacting with U2AF65 and binding to the intron branch site during the formation of the early splicing complex.; Remark: sf1 of D. melanogatser is also called CG5836.; Similarity: the ORF is similar to sf1 of D. melanogaster in a region containing the KH-motiv and the zinc-finger motiv, which are both involved in facilitating nucleic acid binding.; Similarity: the predicted ORF is similar to the sf1 protein of D. melanogaster in inter region, including amino acids 130 to 260, but shows no homology to the N-terminal region of sf1 (RS domain found in several splicing proteins), which is believed to mediate protein-protein or protein-RNA interactions.; Title: similarity to splicing factor sf1 -Drosophila melanogaster; uncharacterized protein 2984473 84590507 An02g12290 Aspergillus niger uncharacterized protein XP_059600108.1 2982295 D 5061 CDS An02g12300 84590508 join(2985543..2985584,2985668..2985912,2986241..2986300,2986393..2986489) IV 1 NT_166519.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF; uncharacterized protein 2986489 84590508 An02g12300 Aspergillus niger uncharacterized protein XP_059600109.1 2985543 D 5061 CDS An02g12310 4979768 join(2986712..2986777,2986830..2987372,2987538..2987552) IV 1 NT_166519.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF; uncharacterized protein 2987552 4979768 An02g12310 Aspergillus niger uncharacterized protein XP_001400359.3 2986712 D 5061 CDS An02g12320 4979769 join(2988635..2988701,2988772..2989383,2989443..2989609) IV 1 NT_166519.1 Function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.; Function: the beta subunit of eIF-2 is necessary for the exchange of GDP with GTP, to enable a new round of translation initiation by eIF-2.; Remark: sui3 of S. cerevisiae is also called TIF212,WP1054 or YPL237w.; Similarity: the predicted ORF overlaps with A. niger ESTs EMBLEST:BE759615 and EMBLEST:BE758850.; Title: strong similarity to translation initiation factor eIF-2 beta chain Sui3 - Saccharomyces cerevisiae; cytoplasm; See PMID 2678106; See PMID 3136928; uncharacterized protein 2989609 4979769 An02g12320 Aspergillus niger uncharacterized protein XP_001400360.3 2988635 D 5061 CDS An02g12330 4979770 complement(join(2990257..2990475,2990540..2990889,2990945..2991388,2991440..2991457,2991514..2991568)) IV 1 NT_166519.1 Remark: a splice site was detected upstream of the START codon.; Similarity: the predicted ORF is 140 amino acids longer at its N-terminus than the homologues hypothetical proteins of the MTH747 superfamily.; Similarity: the predicted ORF shows similarity to some proteins, which are members of the superfamily catagorized by the conserved hypothetical protein MTH747.; Title: strong similarity to hypothetical conserved protein TM0367 - Thermotoga maritima; uncharacterized protein 2991568 4979770 An02g12330 Aspergillus niger uncharacterized protein XP_001400361.1 2990257 R 5061 CDS An02g12340 84590509 join(2991706..2991763,2991963..2992057,2992146..2992265) IV 1 NT_166519.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF; uncharacterized protein 2992265 84590509 An02g12340 Aspergillus niger uncharacterized protein XP_059603524.1 2991706 D 5061 CDS An02g12350 4979772 complement(join(2992430..2995248,2995352..2995880,2995935..2996033)) IV 1 NT_166519.1 Function: the ankyrin repeat is one of the most common protein sequence motifs found in a variety proteins with different activities.; Similarity: the predicted ORF shows similarity to ankyrin isoforms from several species, which is due to the presence of ankyrin-repeat homology domain.; Similarity: the similarity to ankryrin repeat domains is located in the C-terminal part of the predicted ORF, starting around amino acid 900.; Title: similarity to neuronal long splice form of ankyrin ANK2 - Homo sapiens; See PMID 1830053; See PMID 1833308; See PMID 8253844; uncharacterized protein 2996033 4979772 An02g12350 Aspergillus niger uncharacterized protein XP_059603525.1 2992430 R 5061 CDS An02g12360 4979773 complement(join(2996891..2996946,2997041..2997262,2997318..2997714,2997810..2997872)) IV 1 NT_166519.1 Similarity: the predicted ORF overlaps with A. niger ESTs EMBLEST:AN728, EMBLEST:BE758829 and EMBLEST:BE759606.; Similarity: the predicted ORF shows similarities to SH3 domain sequences of several hypothetical proteins.; Title: strong similarity to hypothetical protein csh3p - Schizosaccharomyces pombe; uncharacterized protein 2997872 4979773 An02g12360 Aspergillus niger uncharacterized protein XP_001400364.1 2996891 R 5061 CDS An02g12370 4979774 complement(2998841..2999611) IV 1 NT_166519.1 hypothetical protein 2999611 4979774 An02g12370 Aspergillus niger hypothetical protein XP_001400365.1 2998841 R 5061 CDS An02g12380 84590510 complement(join(2999989..3000046,3000129..3000328,3000374..3000407,3000455..3000465)) IV 1 NT_166519.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF; uncharacterized protein 3000465 84590510 An02g12380 Aspergillus niger uncharacterized protein XP_059603526.1 2999989 R 5061 CDS An02g12390 4979776 join(3000473..3000628,3000711..3001019) IV 1 NT_166519.1 Function: yeast MBF1 mediates GCN4-dependent transcriptional activation by bridging the DNA-binding region of GCN4 and TBP.; Remark: The matching A. niger EST Asc0397 matches the complementary strand, but it is likely that this EST was cloned in the wrong orientation since the splice site is matching exactely this gene model and a poly(A)-tail can be recognized at the 5-end of the EST.; Similarity: yeast MBF1 shows similarity to the bridging molecule that connects the Drosophila nuclear receptor FTZ-F1 and TATA-binding protein (TBP).; Title: strong similarity to multiprotein bridging factor 1 Mbf1 - Saccharomyces cerevisiae; nucleus; See PMID 9710580; uncharacterized protein 3001019 4979776 An02g12390 Aspergillus niger uncharacterized protein XP_001400367.1 3000473 D 5061 CDS An02g12400 84590511 join(3001956..3002111,3002165..3002176,3002246..3002257,3002296..3002371,3002533..3002570) IV 1 NT_166519.1 hypothetical protein 3002570 84590511 An02g12400 Aspergillus niger hypothetical protein XP_059603527.1 3001956 D 5061 CDS An02g12410 4979778 complement(join(<3003262..3003621,3003678..3003794,3003858..3004368,3004493..3004519)) IV 1 NT_166519.1 Function: TIF34 of S. cerevisiae is required for cell cycle progression and for mating and plays an essential role in initiation of protein synthesis.; Remark: a putative sequencing error results in an frameshift.; Remark: the A. niger protein also shows strong similarity to the S. pombe Sum1 protein, the overexpression of which suppresses uncontrolled mitosis 1 in the cdc2-3w.; Similarity: TIF34 of S. cerevisiae and the A. niger protein show strong similarity to human TRIP-1 protein.; Title: strong similarity to translation initiation factor eIF3 subunit Tif34 - Saccharomyces cerevisiae [putative frameshift]; cytoplasm; putative frameshift; See PMID 8972194; See PMID 9671501; uncharacterized protein 3004519 4979778 An02g12410 Aspergillus niger uncharacterized protein XP_059603528.1 3003262 R 5061 CDS An02g12420 4979779 join(3005481..3005604,3005671..3005691,3005748..3005785,3005847..3008375,3008440..>3008521) IV 1 NT_166519.1 Function: the protein product of the ADE3 gene of S. cerevisiae has been identified as the cytoplasmic trifunctional C1-tetrahydrofolate (THF) synthase, which possesses 10-formyl-THF synthetase (EC 6. 3. 4. 3), 5,10-methenyl-THF cyclohydrolase (EC 3. 5. 4. 9), and 5,10-methylene-THF dehydrogenase (EC 1. 5. 1. 5) activities.; Pathway: protein product of the ADE3 gene of S. cerevisiae necessary for the biosynthesis of purines,thymydylate, methionine, histidine, panthotenate, and formyl tRNA-MET.; Remark: a putative sequencing error results in an frameshift.; Title: strong similarity to trifunctional C1-tetrahydrofolate synthase Ade3 - Saccharomyces cerevisiae [putative frameshift]; cytoplasm; putative frameshift; See PMID 8464869; See PMID 3514599; uncharacterized protein 3008521 4979779 An02g12420 Aspergillus niger uncharacterized protein XP_001400370.3 3005481 D 5061 CDS An02g12430 4979780 join(3010242..3010304,3010549..3010584,3010689..3010699,3010762..3010795,3010853..3010991,3011047..3011083,3011143..3011639,3011688..3012112) IV 1 NT_166519.1 Catalytic activity: icdA from A. niger catalyzes the reaction: isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH; Function: the activity of the mitochondrial NADP-dependent isocitrate dehydrogenase of A. niger is inhibited by an accumulation of intracellular glycerol; Gene-ID: icdA; Remark: a splice site was detected upstream of the START codon.; localisation:mitochondrion; See PMID 8885410; precursor of mitochondrial isocitrate dehydrogenase icdA-Aspergillus niger 3012112 icdA 4979780 icdA Aspergillus niger precursor of mitochondrial isocitrate dehydrogenase icdA-Aspergillus niger XP_001400371.1 3010242 D 5061 CDS An02g12440 84590512 complement(join(3013229..3013447,3013728..3013872,3013973..3014498,3014764..3015847)) IV 1 NT_166519.1 Remark: blastp matches are due to repetitive amino acids.; hypothetical protein 3015847 84590512 An02g12440 Aspergillus niger hypothetical protein XP_059603529.1 3013229 R 5061 CDS An02g12450 4979782 complement(join(3016104..3016691,3016727..3017267,3017324..3017427)) IV 1 NT_166519.1 Function: tomato XOPG1 is involved weakening of the endosperm tissue during germination.; Title: similarity to polygalacturonase XOPG1 -Lycopersicon esculentum; See PMID 10517833; uncharacterized protein 3017427 4979782 An02g12450 Aspergillus niger uncharacterized protein XP_059603530.1 3016104 R 5061 CDS An02g12460 4979783 join(3017506..3017628,3017752..3017789,3017845..3017892,3018032..3018725) IV 1 NT_166519.1 Title: strong similarity to EST SEQ ID NO:4225 from patent WO200056762-A2 - Aspergillus niger; uncharacterized protein 3018725 4979783 An02g12460 Aspergillus niger uncharacterized protein XP_001400374.3 3017506 D 5061 CDS An02g12470 4979784 join(3021132..3021625,3021655..3022375) IV 1 NT_166519.1 Title: weak similarity to protein kinase Elm1 -Saccharomyces cerevisiae; uncharacterized protein 3022375 4979784 An02g12470 Aspergillus niger uncharacterized protein XP_059603531.1 3021132 D 5061 CDS An02g12480 4979785 complement(join(3022659..3022708,3022758..3022779,3022883..3022903,3023072..3023119,3023194..3024917,3024976..3025099)) IV 1 NT_166519.1 Title: weak similarity to mitochondrial transcription factor mtTFB - Kluyveromyces lactis; uncharacterized protein 3025099 4979785 An02g12480 Aspergillus niger uncharacterized protein XP_001400376.3 3022659 R 5061 CDS An02g12490 4979786 join(3025622..3025765,3025823..3025987,3026043..3027329) IV 1 NT_166519.1 Remark: the function of the protein from EP1033405-A2 has not been described.; Title: similarity to protein fragment SEQ ID NO:24712 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 3027329 4979786 An02g12490 Aspergillus niger uncharacterized protein XP_001400377.1 3025622 D 5061 CDS An02g12500 4979787 3027563..3028522 IV 1 NT_166519.1 Remark: other uses include peptide hydrolysis, waste treatment and cleavage of fusion proteins.; Remark: the B. subtilis hydrolase YQJL as well as other recombinant hydrolases from gram-positive bacteria are useful in cleaning (e. g. detergent) or textile treatment compositions, and in animal feeds.; Title: similarity to hydrolase protein YQJL from patent WO9927081-A2 - Bacillus subtilis; uncharacterized protein 3028522 4979787 An02g12500 Aspergillus niger uncharacterized protein XP_001400378.1 3027563 D 5061 CDS An02g12503 4979788 3029354..3030265 IV 1 NT_166519.1 Function: a tfs1 deletion strain of S. pombe has a slow growth phenotype and increased sensitivity to the drug 6-azauracil.; Remark: tfs1 from S. pombe is not essential for viability since a haploid S. pombe strain with tfs1 deleted from the genome is viable.; Similarity: tfs1 from S. pombe shows similarities to genes of other organisms encoding transcription elongation factor TFIIS.; Title: strong similarity to transcription elongation factor TFIIS encoded by tfs1p - Schizosaccharomyces pombe; nucleus; See PMID 8904334; uncharacterized protein 3030265 4979788 An02g12503 Aspergillus niger uncharacterized protein XP_001400379.1 3029354 D 5061 CDS An02g12505 4979789 complement(join(3031053..3031607,3031673..3032311)) IV 1 NT_166519.1 Function: the expressed protein PMEA from Aspergillus had a molecular mass of 38. 5 kDa, a pH optimum of 5. 0, and a temperature optimum of 55 degrees C.; Similarity: pmeA from Aspergillus oryzae is very similar to those of Aspergillus niger PMEA and Aspergillus aculeatus PME1.; Title: similarity to pectin methylesterase pmeA -Aspergillus oryzae; See PMID 10052131; uncharacterized protein 3032311 4979789 An02g12505 Aspergillus niger uncharacterized protein XP_001400380.1 3031053 R 5061 CDS An02g12507 84590513 join(3032971..3032973,3033007..3033132,3033170..3033287,3033479..3033570) IV 1 NT_166519.1 hypothetical protein 3033570 84590513 An02g12507 Aspergillus niger hypothetical protein XP_059603532.1 3032971 D 5061 CDS An02g12510 4979791 complement(join(<3034655..3037007,3037067..3037290,3037346..3037742)) IV 1 NT_166519.1 Catalytic activity: H(+)[intracellular] + ATP + H2O = H(+)[extracellular] + ADP + phosphate.; Function: a proton gradient across the plasma membrane is important for many proton-driven transport functions.; Function: pmaA of A. nidulans is involved in proton homeostasis and establishment/maintanance of a proton gradient across the plasma membrane.; Remark: a putative sequencing error results in a frameshift.; Title: strong similarity to plasma membrane H(+)-ATPase pmaA - Aspergillus nidulans [putative frameshift]; plasma membrane; putative frameshift; See PMID 11131024; uncharacterized protein 3037742 4979791 An02g12510 Aspergillus niger uncharacterized protein XP_059603533.1 3034655 R 5061 CDS An02g12520 84590514 complement(join(3038095..3038174,3038290..3038350,3038410..3038546,3038586..3038702,3038783..3038973,3039084..3039254,3039365..3039528)) IV 1 NT_166519.1 hypothetical protein 3039528 84590514 An02g12520 Aspergillus niger hypothetical protein XP_059603534.1 3038095 R 5061 CDS An02g12530 84590515 complement(join(3040093..3040230,3040347..3040421)) IV 1 NT_166519.1 Title: questionable ORF; uncharacterized protein 3040421 84590515 An02g12530 Aspergillus niger uncharacterized protein XP_059603535.1 3040093 R 5061 CDS An02g12540 84590516 join(3040813..3040882,3040980..3041155,3041489..3041554,3041629..3041709,3041750..3041862,3041939..3042023) IV 1 NT_166519.1 hypothetical protein 3042023 84590516 An02g12540 Aspergillus niger hypothetical protein XP_059603536.1 3040813 D 5061 CDS An02g12550 84590517 complement(join(3042341..3042472,3042562..3042642)) IV 1 NT_166519.1 Title: questionable ORF; uncharacterized protein 3042642 84590517 An02g12550 Aspergillus niger uncharacterized protein XP_059603537.1 3042341 R 5061 CDS An02g12560 84590518 join(3043315..3043433,3043657..3043741,3043831..3043906,3044257..3044321,3044416..3044584,3044691..3044736,3044961..3045064,3045218..3045319,3045705..3045820,3045959..3045990,3046064..3046166) IV 1 NT_166519.1 hypothetical protein 3046166 84590518 An02g12560 Aspergillus niger hypothetical protein XP_059603538.1 3043315 D 5061 CDS An02g12570 84590519 join(3046331..3046399,3046622..3046990,3047067..3047198,3047389..3047483,3047508..3047644,3047922..3048037) IV 1 NT_166519.1 hypothetical protein 3048037 84590519 An02g12570 Aspergillus niger hypothetical protein XP_059603539.1 3046331 D 5061 CDS An02g12580 84590520 complement(join(3048808..3048923,3049016..3049127,3049388..3049393,3049660..3049732,3049976..3050031,3050100..3050117,3050668..3050673)) IV 1 NT_166519.1 hypothetical protein 3050673 84590520 An02g12580 Aspergillus niger hypothetical protein XP_059603540.1 3048808 R 5061 CDS An02g12590 84590521 join(3051762..3051825,3051901..3051951,3052034..3052113) IV 1 NT_166519.1 Title: questionable ORF; uncharacterized protein 3052113 84590521 An02g12590 Aspergillus niger uncharacterized protein XP_059603541.1 3051762 D 5061 CDS An02g12600 4979800 complement(join(3052705..3052829,3052894..3053133,3053199..3053600,3053632..3053779,3053840..3054091,3054343..3054378)) IV 1 NT_166519.1 Similarity: belongs to the family of metal-dependent hydrolases of the beta-lactamase superfamily II.; Title: similarity to hypothetical hydrolase MJ0301 -Methanococcus jannaschii; uncharacterized protein 3054378 4979800 An02g12600 Aspergillus niger uncharacterized protein XP_059603542.1 3052705 R 5061 CDS An02g12610 4979801 complement(3054963..3056216) IV 1 NT_166519.1 Function: Rna1 of S. pombe regulates the activity of Ran-GTPase which is involved in the control of nuclear-cytoplasmic export/import.; Localization: Rna1 of S. pombe is concentrated around the nucleus.; Phenotype: rna1 mutants of S. pombe are impaired in processing and/or export of RNA (all types) from the nucleus.; Similarity: the A. niger protein, like Rna1 of S. pombe, contains a leucine rich repeat domain and an acid rich region in the C-terminal part of the sequence.; Title: strong similarity to Ran-GTPase-activating protein 1 rna1p - Schizosaccharomyces pombe; cytoplasm; See PMID 8374168; See PMID 9121474; uncharacterized protein 3056216 4979801 An02g12610 Aspergillus niger uncharacterized protein XP_001400392.1 3054963 R 5061 CDS An02g12620 4979802 join(3056659..3056686,3056783..3056838,3056900..3057040) IV 1 NT_166519.1 Function: Cox17p of S. cerevisiae shuttles Cu(I) ions to the mitochondrial intermembrane space, which is necessary for the assembly of functional cytochrome c oxidase.; Function: Cu(I) ions in Cox17p of S. cerevisiae are liganded in a binuclear cuprous cysteinyl-thiolate cluster.; Phenotype: mutations in the COX17 gene of S. cerevisiae cause a respiratory deficiency due to a block in the production of a functional cytochrome oxidase complex.; Similarity: nearly identical to Aspergillus niger EST SEQ ID NO:4014 of patent WO200056762-A2 (PATENTDNA:AAF11491).; Title: strong similarity to copper metallochaperone Cox17 - Saccharomyces cerevisiae [putative sequencing error]; cytoplasm; putative sequencing error; See PMID 8662933; See PMID 9407107; See PMID 9585572; See PMID 10970896; uncharacterized protein 3057040 4979802 An02g12620 Aspergillus niger uncharacterized protein XP_001400393.1 3056659 D 5061 CDS An02g12630 4979803 complement(join(3057410..3058188,3058285..3058790,3058839..3059001,3059056..3059290)) IV 1 NT_166519.1 Catalytic activity: glucosyl-dolichyl-phosphate + Man9GlcNAc2-dolichyl-pyrophosphate = dolichyl-phosphate + Glc1Man9GlcNAc2-dolichyl-pyrophosphate.; Function: Alg6p of S. cerevisiae is involved in the synthesis of the dolichyl pyrophosphate-linked oligosaccharide precursor.; Pathway: Alg6p of S. cerevisiae is involved in the N-glycosylation pathway.; Title: strong similarity to glucosyltransferase Alg6 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 8877369; uncharacterized protein 3059290 4979803 An02g12630 Aspergillus niger uncharacterized protein XP_059603543.1 3057410 R 5061 CDS An02g12640 4979804 join(3060112..3060816,3060868..3061148,3061200..3061830) IV 1 NT_166519.1 Function: High levels of CP-RBP30 mRNA was found in leaves but not in roots.; Remark: CP-RBP30 and is targeted to chloroplasts.; Title: strong similarity to RNA-binding protein 30 -Nicotiana plumbaginifolia; nucleus; See PMID 1406585; uncharacterized protein 3061830 4979804 An02g12640 Aspergillus niger uncharacterized protein XP_059603544.1 3060112 D 5061 CDS An02g12650 4979805 <3063057..3064238 IV 1 NT_166519.1 Remark: ORF 5'truncated due to end of contig.; Remark: blastp with the predicted A. niger protein only retrieves random hits to serine rich proteins.; hypothetical protein [truncated ORF] 3064238 4979805 An02g12650 Aspergillus niger hypothetical protein [truncated ORF] XP_001400396.3 3063057 D 5061 CDS An02g12660 84590522 complement(3064907..3065374) IV 1 NT_166519.1 hypothetical protein 3065374 84590522 An02g12660 Aspergillus niger hypothetical protein XP_059603545.1 3064907 R 5061 CDS An02g12670 4979807 complement(join(3065746..3067035,3067082..3067407,3067464..3067482,3067539..3067688)) IV 1 NT_166519.1 Catalytic activity: gamma-glutamyltransferases convert (5-L-glutamyl)-peptide + an amino acid to peptide + 5-L-glutamyl-amino acid.; Function: B. subtilis ggt catalyzes the transfer of the gamma-glutamyl group from gamma-glutamyl compounds (such as glutathione) to amino acids, peptide acceptors, or H(2)O.; Function: B. subtilis ggt plays a major role in glutathione (L-g-glutamyl-L-cysteinylglycine) metabolism and is involved in polyglutamate production.; Function: glutathione is involved in the maintenance of protein thiol group status and reduction of highly reactive forms of oxygen and free radicals.; Function: in bacteria and mammals ggt is the only protease known to cleave intact glutathione.; Localization: mammalian ggt is located at the external surface of epithelial cells.; Title: similarity to NR-1 gamma-glutamyltranspeptidase ggt - Bacillus subtilis; See PMID 10392451; See PMID 8763966; uncharacterized protein 3067688 4979807 An02g12670 Aspergillus niger uncharacterized protein XP_059603546.1 3065746 R 5061 CDS An02g12680 4979808 join(3068430..3069621,3069685..3069788,3069897..3070007) IV 1 NT_166519.1 Catalytic activity: acetylornithine deacetylases convert N2-acetyl-L-ornithine + H(2)O to acetate + L-ornithine.; Function: M. xanthus argE is involved in arginine biosynthesis.; Title: similarity to acetylornithine deacetylase argE - Myxococcus xanthus; See PMID 9829957; uncharacterized protein 3070007 4979808 An02g12680 Aspergillus niger uncharacterized protein XP_001400399.3 3068430 D 5061 CDS An02g12690 84590523 join(3070436..3070538,3070615..3070715,3070773..3070854,3070910..3071059,3071122..3071228,3071281..3071363,3071433..3071464,3071502..3071617) IV 1 NT_166519.1 Similarity: the predicted A. niger protein shows similarity to several hypothetical isochorismatases and contains a isochorismatases motif.; Title: similarity to hypothetical protein yaaI -Escherichia coli; uncharacterized protein 3071617 84590523 An02g12690 Aspergillus niger uncharacterized protein XP_059603547.1 3070436 D 5061 CDS An02g12700 84590524 complement(join(3072148..3072254,3072330..3072474,3072572..3072628,3072732..3073001)) IV 1 NT_166519.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 3073001 84590524 An02g12700 Aspergillus niger uncharacterized protein XP_059603548.1 3072148 R 5061 CDS An02g12710 84590525 complement(join(3073275..3073673,3073839..3074191,3074257..3074302)) IV 1 NT_166519.1 Title: weak similarity to hypothetical protein encoded by An17g00030 - Aspergillus niger; uncharacterized protein 3074302 84590525 An02g12710 Aspergillus niger uncharacterized protein XP_059603549.1 3073275 R 5061 CDS An02g12720 84590526 join(3074325..3074394,3074518..3074557,3074853..3074971,3075056..3075124,3075230..3075360,3075401..3075523) IV 1 NT_166519.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 3075523 84590526 An02g12720 Aspergillus niger uncharacterized protein XP_059603550.1 3074325 D 5061 CDS An02g12730 84590527 complement(join(3075589..3075702,3075796..3075864,3075958..3076136,3076427..3076638,3076733..3076918,3077069..3077164,3077298..3077453,3077527..3077555,3077651..3077818,3077895..3077954)) IV 1 NT_166519.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 3077954 84590527 An02g12730 Aspergillus niger uncharacterized protein XP_059603551.1 3075589 R 5061 CDS An02g12740 84590528 join(3078246..3078256,3078309..3078395,3078545..3078590) IV 1 NT_166519.1 Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 3078590 84590528 An02g12740 Aspergillus niger uncharacterized protein XP_059603552.1 3078246 D 5061 CDS An02g12750 4979815 complement(join(3080263..3081117,3081171..3081743,3081795..3081824,3081876..3081905,3081958..3081980,3082033..3082084,3082140..3082187)) IV 1 NT_166519.1 Alternative name: an alternativ name for the S. cerevisiae Cct chaperonin complex is TCP-1.; Complex: in S. cerevisiae CCT1-8 form the Cct chaperonin complex.; Function: S. cerevisiae CCT8 is a subunit of the Cct chaperonin complex which binds to newly synthesized actin and tubulin and can convert these proteins into an assembly-competent state.; Localization: S. cerevisiae CCT localized to the cytoplasm and the cell cortex.; Similarity: S. cerevisiae CCT shows similarity to GroEl.; Title: strong similarity to cytoskeleton specific chaperonin subunit Cct4 - Saccharomyces cerevisiae; See PMID 7865875; See PMID 7916461; See PMID 8771707; uncharacterized protein 3082187 4979815 An02g12750 Aspergillus niger uncharacterized protein XP_001400406.1 3080263 R 5061 CDS An02g12760 4979816 join(3082542..3082636,3082710..3082824,3082878..3083107,3083157..3084036) IV 1 NT_166519.1 Function: S. cerevisiae Rpt1p is one of 6 different ATPases of the 17 subunit regulatory particle of the 26S proteasome.; Title: strong similarity to proteasome 19S regulatory particle subunit Rpt1 - Saccharomyces cerevisiae; See PMID 9584156; See PMID 10872471; uncharacterized protein 3084036 4979816 An02g12760 Aspergillus niger uncharacterized protein XP_001400407.1 3082542 D 5061 CDS An02g12770 4979817 join(3084810..3084851,3084948..3084999,3085060..3085133,3085190..3085353,3085409..3086797,3086853..3087072) IV 1 NT_166519.1 Remark: S. cerevisiae SDH1 is the flavoprotein subunit of the mitochondrial matrix succinate dehydrogenase heterotetramer.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_2833 and an_1386.; Title: strong similarity to succinate dehydrogenase Sdh1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9929002; uncharacterized protein 3087072 4979817 An02g12770 Aspergillus niger uncharacterized protein XP_001400408.1 3084810 D 5061 CDS An02g12780 84590529 join(3087899..3088574,3088647..3089164) IV 1 NT_166519.1 Function: S. cerevisiae WSC2 is a plasme membrane localised regulator of the PKC1-MPK1 pathway.; Similarity: similarity of the predicted A. niger protein to S. cerevisiae WSC2 is mostly due to serine repeats.; Title: weak similarity to cell wall integrity and stress response factor Wsc2 - Saccharomyces cerevisiae; See PMID 9391108; uncharacterized protein 3089164 84590529 An02g12780 Aspergillus niger uncharacterized protein XP_059603553.1 3087899 D 5061 CDS An02g12790 4979819 complement(join(3089417..3089692,3089752..3089952,3090043..3090176,3090231..3090486)) IV 1 NT_166519.1 Catalytic activity: 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylases convert 5-oxopent-3-ene-1,2, 5-tricarboxylate to 2-oxohept-3-enedioate + CO(2).; Function: E. coli hpcE is a 5-carboxymethyl-2-hydroxymuconate delta-isomerase and 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase.; Function: E. coli hpcE is involved in the utilisation of homoprotocatechuate and hydroxyphenylacetate.; Title: similarity to bifunctional OPET decarboxylase/HHDD isomerase hpcE - Escherichia coli; See PMID 8223600; uncharacterized protein 3090486 4979819 An02g12790 Aspergillus niger uncharacterized protein XP_001400410.1 3089417 R 5061 CDS An02g12800 4979820 complement(join(3091351..3091795,3091825..3092140,3092232..3092478)) IV 1 NT_166519.1 Catalytic activity: gentisate 1,2-dioxygenases convert 2,5-dihydroxybenzoate + O(2) to maleylpyruvate.; Complex: P. alcaligenes gdo is a homodimer.; Function: P. alcaligenes gdo is involved in the utilisation of 3-hydroxybenzoate as a carbon source.; Induction: P. alcaligenes gdo is 3-hydroxybenzoate-inducible.; Title: similarity to gentisate 1,2-dioxygenases gdo - Pseudomonas alcaligenes; See PMID 10049846; uncharacterized protein 3092478 4979820 An02g12800 Aspergillus niger uncharacterized protein XP_001400411.3 3091351 R 5061 CDS An02g12810 4979821 complement(join(3092799..3092826,3093036..3093235,3093298..3093456)) IV 1 NT_166519.1 Title: weak similarity to protein SEQ ID NO: #2154 from patent US6562958-B1 - Acinetobacter baumannii; uncharacterized protein 3093456 4979821 An02g12810 Aspergillus niger uncharacterized protein XP_059603554.1 3092799 R 5061 CDS An02g12820 4979822 complement(join(3093983..3094129,3094181..3094945)) IV 1 NT_166519.1 Catalytic activity: Aryl-alcohol dehydrogenases convert an aromatic alcohol + NAD(+) to an aromatic aldehyde + NADH.; Function: Acinetobacter areB is involved in the catabolism of aromatic alcohol esters, accepting a range of substituted aromatic compounds as substrate.; Induction: expression of Acinetobacter areB is induced by benzyl acetate, benzyl alcohol, and benzaldehyde, as well as 2- and 4-hydroxybenzyl acetates and benzyl propionate and butyrate.; Title: strong similarity to benzyl alcohol dehydrogenase areB - Acinetobacter sp. [putative sequencing error]; putative sequencing error; See PMID 10419955; See PMID 11114944; uncharacterized protein 3094945 4979822 An02g12820 Aspergillus niger uncharacterized protein XP_059603555.1 3093983 R 5061 CDS An02g12830 4979823 join(3095292..3095334,3095484..3096585,3096641..3097066,3097124..3097368,3097468..3097868) IV 1 NT_166519.1 Similarity: similarity is between the central regions of the predicted A. niger protein and F. solani CTF1.; Title: similarity to cutinase transcription factor alpha CTF1a - Fusarium solani; nucleus; See PMID 9139694; uncharacterized protein 3097868 4979823 An02g12830 Aspergillus niger uncharacterized protein XP_059603556.1 3095292 D 5061 CDS An02g12840 84590530 complement(join(3097912..3097977,3098070..>3098555)) IV 1 NT_166519.1 Remark: ORF 5'truncated due to end of contig, the N-terminal region is represented by the predicted ORF An02g12850.; hypothetical protein [truncated ORF] 3098555 84590530 An02g12840 Aspergillus niger hypothetical protein [truncated ORF] XP_059603557.1 3097912 R 5061 CDS An02g12850 4979825 complement(join(<3098818..3099296,3099541..3099566,3099775..3099889,3100608..3101376)) IV 1 NT_166519.1 Remark: ORF 3'truncated due to end of contig.; Remark: blastp with the predicted A. niger protein probably only retrieves random hits to proline rich proteins.; Title: weak similarity to SH3 domain binding protein CR16 - Rattus norvegicus [truncated ORF]; See PMID 8839352; See PMID 8906616; uncharacterized protein 3101376 4979825 An02g12850 Aspergillus niger uncharacterized protein XP_059600110.1 3098818 R 5061 CDS An02g12860 84590531 complement(join(3101751..3101915,3102050..3102208)) IV 1 NT_166519.1 hypothetical protein 3102208 84590531 An02g12860 Aspergillus niger hypothetical protein XP_059600111.1 3101751 R 5061 CDS An02g12870 84590532 complement(join(3102283..3102380,3102473..3102536,3102609..3102679,3102847..3102946)) IV 1 NT_166519.1 hypothetical protein 3102946 84590532 An02g12870 Aspergillus niger hypothetical protein XP_059600112.1 3102283 R 5061 CDS An02g12880 4979828 join(3103649..3103678,3103731..3103944,3104044..3104123) IV 1 NT_166519.1 hypothetical protein 3104123 4979828 An02g12880 Aspergillus niger hypothetical protein XP_001400419.1 3103649 D 5061 CDS An02g12890 84590533 complement(join(3104259..3104330,3104518..3104800,3104955..3105028)) IV 1 NT_166519.1 Remark: blastp with the predicted A. niger protein only retrieves random hits to glycine rich proteins.; hypothetical protein 3105028 84590533 An02g12890 Aspergillus niger hypothetical protein XP_059600113.1 3104259 R 5061 CDS An02g12900 4979830 join(3105621..3106204,3106485..3106552,3106593..3106654) IV 1 NT_166519.1 Title: similarity to hypothetical protein encoded by An04g10150 - Aspergillus niger; uncharacterized protein 3106654 4979830 An02g12900 Aspergillus niger uncharacterized protein XP_001400421.3 3105621 D 5061 CDS An02g12910 84590534 join(3107368..3107473,3107576..3108042) IV 1 NT_166519.1 Title: weak similarity to hypothetical protein PM0349 - Pasteurella multocida; uncharacterized protein 3108042 84590534 An02g12910 Aspergillus niger uncharacterized protein XP_059600114.1 3107368 D 5061 CDS An02g12920 4979832 join(3108758..3109539,3109613..3110807) IV 1 NT_166519.1 Remark: C-terminal region and 3'UTR of the predicted A. niger protein are in accordance with A. niger EST AN07F11 EMBLEST:ANI239976.; Similarity: the predicted A. niger protein shows similarity to several hypothetical ABC-transporter proteins and contains an unusual kinase domain.; Title: strong similarity to hypothetical protein SPAC10F6.14c - Schizosaccharomyces pombe; uncharacterized protein 3110807 4979832 An02g12920 Aspergillus niger uncharacterized protein XP_059600115.1 3108758 D 5061 CDS An02g12930 4979833 complement(join(3112333..3112340,3112382..3114056)) IV 1 NT_166519.1 Function: S. aureofaciens tcrC is a tetracycline efflux pump of the major facilitator familiy.; Title: similarity to tetracycline efflux pump tcrC -Streptomyces aureofaciens; plasma membrane; See PMID 8534971; uncharacterized protein 3114056 4979833 An02g12930 Aspergillus niger uncharacterized protein XP_001400424.3 3112333 R 5061 CDS An02g12940 4979834 join(3114632..3114718,3114822..3115304,3115374..3115565) IV 1 NT_166519.1 Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_ 3344.; Title: strong similarity to EST an_3344 -Aspergillus niger; uncharacterized protein 3115565 4979834 An02g12940 Aspergillus niger uncharacterized protein XP_001400425.1 3114632 D 5061 CDS An02g12950 84590535 3116567..3118636 IV 1 NT_166519.1 Function: het-6 of N. crassa is involved in the restriction of heterokaryon formation during asexual growth.; Remark: in filamentous fungi, vegetative cell fusion between genotypically distinct individuals leads to a cell-death reaction known as vegetative or heterokaryon incompatibility.; Similarity: het-6(OR) of N. crassa has three regions of amino acid sequence similarity to the predicted product of the het-e vegetative incompatibility gene in P. anserina and to the predicted product of tol, which mediates mating-type vegetative incompatibility in N. crassa.; Title: similarity to heterokaryon incompatibility factor het-6 - Neurospora crassa; See PMID 10880472; See PMID 11035941; See PMID 11092825; uncharacterized protein 3118636 84590535 An02g12950 Aspergillus niger uncharacterized protein XP_059600116.1 3116567 D 5061 CDS An02g12960 84590536 complement(3119084..>3119917) IV 1 NT_166519.1 Remark: C-terminal region and 3'UTR of the predicted A. niger protein are covered by the A. niger EST an_2701 .; Remark: ORF 5'truncated due to end of contig, the N-terminal region is represented by the predicted ORF An02g12970.; Similarity: the predicted A. niger protein shows weak similarity to proline rich proteins.; Title: weak similarity to intestinal mucin MUC2 -Homo sapiens [truncated ORF]; uncharacterized protein 3119917 84590536 An02g12960 Aspergillus niger uncharacterized protein XP_059600117.1 3119084 R 5061 CDS An02g12970 4979837 complement(join(<3120044..3121010,3121056..3121108,3121267..3123656,3123703..3124215,3124328..3124428)) IV 1 NT_166519.1 Localization: C. thermocellum ancA is a cell surface protein.; Remark: ORF 3'truncated due to end of contig, the C-terminal region is represented by the predicted ORF An02g12960.; Similarity: the predicted A. niger protein shows weak similarity to several extracellular and cell wall associated proline rich exo-alpha-sialidases.; Title: weak similarity to cellulosome attachment protein ancA - Clostridium thermocellum [truncated ORF]; See PMID 8458832; uncharacterized protein 3124428 4979837 An02g12970 Aspergillus niger uncharacterized protein XP_059600118.1 3120044 R 5061 CDS An02g12980 4979838 join(3124738..3124987,3125037..3125218,3125265..3125828,3125878..3125913) IV 1 NT_166519.1 Function: S. cerevisiae Sed5p has an essential role in vesicular transport between ER and Golgi compartments.; Golgi; Localization: immuno-EM reveals that the majority of S. cerevisiae Sed5p is in a tubulo-vesicular compartment on the cis side of the Golgi apparatus.; Similarity: S. cerevisiae Sed5 is a member of the syntaxin family.; Title: strong similarity to cis-Golgi t-SNARE Sed5 -Saccharomyces cerevisiae; See PMID 10515003; See PMID 1400588; See PMID 7929581; uncharacterized protein 3125913 4979838 An02g12980 Aspergillus niger uncharacterized protein XP_001400429.1 3124738 D 5061 CDS An02g12990 84590537 join(3127260..3127445,3127570..3127686,3127793..3128044,3128141..3128203) IV 1 NT_166519.1 Title: weak similarity to hypothetical translation initiation factor IF-2 F28O16.19 - Arabidopsis thaliana; uncharacterized protein 3128203 84590537 An02g12990 Aspergillus niger uncharacterized protein XP_059600119.1 3127260 D 5061 CDS An02g13000 84590538 complement(join(3128474..3128725,3128864..3129020,3129305..3129342,3129467..3129553)) IV 1 NT_166519.1 hypothetical protein 3129553 84590538 An02g13000 Aspergillus niger hypothetical protein XP_059600120.1 3128474 R 5061 CDS An02g13010 84590539 join(3131870..3132040,3132107..3132220,3132288..3132327,3132364..3132402,3132454..3132482) IV 1 NT_166519.1 hypothetical protein 3132482 84590539 An02g13010 Aspergillus niger hypothetical protein XP_059600121.1 3131870 D 5061 CDS An02g13020 84590540 join(3133604..3133750,3133863..3134117) IV 1 NT_166519.1 hypothetical protein 3134117 84590540 An02g13020 Aspergillus niger hypothetical protein XP_059600122.1 3133604 D 5061 CDS An02g13030 84590541 complement(join(3134440..3134543,3134640..3134667)) IV 1 NT_166519.1 Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 3134667 84590541 An02g13030 Aspergillus niger uncharacterized protein XP_059600123.1 3134440 R 5061 CDS An02g13040 4979844 join(3135752..3136024,3136096..3136320,3136406..3136540) IV 1 NT_166519.1 Function: Xanthobacter Py2 XamoC is one of 6 subunits of the alkene monooxygenase Xamo, which oxidizes benzene, toluene, and phenol converting them to carbon sources.; Title: weak similarity to ferredoxin aamC -Xanthobacter sp.; See PMID 10103255; uncharacterized protein 3136540 4979844 An02g13040 Aspergillus niger uncharacterized protein XP_001400435.3 3135752 D 5061 CDS An02g13050 4979845 complement(join(3137636..3137789,3137843..3138705,3138760..3139149,3139204..3139272)) IV 1 NT_166519.1 Remark: Alterations of the azole target enzyme and the overexpression of multidrug efflux transporter genes are the most frequent azole resistance mechanisms in Candida albicans.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353; uncharacterized protein 3139272 4979845 An02g13050 Aspergillus niger uncharacterized protein XP_001400436.1 3137636 R 5061 CDS An02g13060 84590542 complement(join(3140047..3140298,3140343..3140490,3140592..3140954,3140984..3141036)) IV 1 NT_166519.1 Title: weak similarity to hypothetical DNA gyrase subunit A VC1258 - Vibrio cholerae; uncharacterized protein 3141036 84590542 An02g13060 Aspergillus niger uncharacterized protein XP_059600124.1 3140047 R 5061 CDS An02g13070 84590543 join(3142052..3142135,3142260..3142297,3142354..3142458,3142503..3142572,3142665..3142889,3143024..3143101) IV 1 NT_166519.1 hypothetical protein 3143101 84590543 An02g13070 Aspergillus niger hypothetical protein XP_059600125.1 3142052 D 5061 CDS An02g13080 4979848 complement(3143120..3144418) IV 1 NT_166519.1 Catalytic activity: Indoleacetate-lysine ligases convert ATP + indole-3-acetate + L-lysine to ADP + n6-[(indole-3-yl)acetyl]-L-lysine.; Function: P. savastanoi iaaL converts the plant gall inducing indole-3-acetate (iaa) to iaa-lysine.; Similarity: P. savastanoi iaaL shows similarity to other enzymes which act via an ATP-dependent covalent binding of AMP to their substrate.; Title: similarity to N epsilon-(indole-3-acetyl)-L-lysine synthase iaaL -Pseudomonas syringae; See PMID 2377619; uncharacterized protein 3144418 4979848 An02g13080 Aspergillus niger uncharacterized protein XP_001400439.1 3143120 R 5061 CDS An02g13090 4979849 join(3145201..3145669,3145719..3146371) IV 1 NT_166519.1 Function: C. carbonum TOXG encodes an alanine racemase whose function is to convert L-Ala to D-Ala for incorporation into HC-toxin.; Title: strong similarity to alanine racemase TOXG -Cochliobolus carbonum; See PMID 10671527; uncharacterized protein 3146371 4979849 An02g13090 Aspergillus niger uncharacterized protein XP_001400440.1 3145201 D 5061 CDS An02g13100 4979850 join(3147364..3148180,3148221..3148665,3148720..3149011,3149062..3149469) IV 1 NT_166519.1 Title: weak similarity to transcription activator Ppr1 - Saccharomyces cerevisiae; See PMID 6096561; uncharacterized protein 3149469 4979850 An02g13100 Aspergillus niger uncharacterized protein XP_059600126.1 3147364 D 5061 CDS An02g13110 84590544 complement(join(3149676..3150195,3150328..3150359)) IV 1 NT_166519.1 Remark: blastp with the predicted A. niger protein mostly retrieves random hits to proline rich proteins.; Title: weak similarity to aortic carboxypeptidase-like protein ACLP from patent WO9921965-A2 - Homo sapiens; uncharacterized protein 3150359 84590544 An02g13110 Aspergillus niger uncharacterized protein XP_059600127.1 3149676 R 5061 CDS An02g13120 4979852 join(3150790..3150984,3151042..3151509) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein encoded by An04g08050 - Aspergillus niger; uncharacterized protein 3151509 4979852 An02g13120 Aspergillus niger uncharacterized protein XP_001400443.3 3150790 D 5061 CDS An02g13130 4979853 complement(join(3151871..3152080,3152155..3152199,3152268..3152630,3152696..3152872)) IV 1 NT_166519.1 Similarity: the predicted A. niger protein contains a neutral zinc metallopeptidases, zinc-binding region signature.; Title: strong similarity to hypothetical protein CAC18209.1 - Neurospora crassa; uncharacterized protein 3152872 4979853 An02g13130 Aspergillus niger uncharacterized protein XP_001400444.1 3151871 R 5061 CDS An02g13140 4979854 complement(join(3154518..3155125,3155180..3155483)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein EAA60090.1 - Aspergillus nidulans; uncharacterized protein 3155483 4979854 An02g13140 Aspergillus niger uncharacterized protein XP_001400445.1 3154518 R 5061 CDS An02g13150 4979855 complement(join(3157419..3157896,3157948..3159166,3159251..3159440)) IV 1 NT_166519.1 Function: A. nidulans palI mutations mimic the effects of acidic growth pH and homology of PalI to S. cerevisiae Rim9p meiotic signal transduction component suggest that PalI might be a membrane sensor for ambient pH.; Title: similarity to membrane sensor for ambient pH palI - Aspergillus nidulans; See PMID 7830727; See PMID 9791171; uncharacterized protein 3159440 4979855 An02g13150 Aspergillus niger uncharacterized protein XP_001400446.1 3157419 R 5061 CDS An02g13160 4979856 complement(join(3161319..3162983,3163099..3163135,3163171..3163328)) IV 1 NT_166519.1 Function: C. albicans CFL1 is a surface-associated ferric reductase involved in iron homeostasis.; Function: C. albicans CFL1 is able to complement mutations in the S. cerevisiae cell surface metalloreductases fre1 that is required for reduction and uptake of free ferric iron.; Regulation: C. albicans CFL1 is regulated in response to levels of iron and copper.; Title: similarity to ferric reductase CFL1 - Candida albicans; plasma membrane; See PMID 10784045; See PMID 11120744; uncharacterized protein 3163328 4979856 An02g13160 Aspergillus niger uncharacterized protein XP_059605165.1 3161319 R 5061 CDS An02g13170 84590545 join(3164510..3164658,3164751..3164834,3164981..3165124,3165392..3165457,3165549..3165639) IV 1 NT_166519.1 hypothetical protein 3165639 84590545 An02g13170 Aspergillus niger hypothetical protein XP_059605166.1 3164510 D 5061 CDS An02g13180 4979858 join(3166236..3166510,3166598..3166694,3166768..3166934,3166993..3167273,3167330..3167751,3167802..3168167,3168228..3168704,3168768..3169520) IV 1 NT_166519.1 Function: T. harzianum lam1. 3 is a lytic enzyme involved in degradation of host cell walls, enabling utilisation of both their cell walls and cellular contents for nutrition.; Title: strong similarity to beta-1,3-exoglucanase lam1.3 - Trichoderma atroviride; extracellular/secretion proteins; See PMID 9931476; uncharacterized protein 3169520 4979858 An02g13180 Aspergillus niger uncharacterized protein XP_001400449.3 3166236 D 5061 CDS An02g13190 4979859 join(3170378..3170423,3170516..3172950) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein 7C14.090 - Neurospora crassa; uncharacterized protein 3172950 4979859 An02g13190 Aspergillus niger uncharacterized protein XP_001400450.1 3170378 D 5061 CDS An02g13200 4979860 join(3173706..3173765,3173811..3174422,3174471..3174611,3174657..3175414,3175506..3176376) IV 1 NT_166519.1 Remark: blastp with the predicted A. niger protein mostly retrieves random hits to serine, proline, threonine and glutamine rich proteins.; Similarity: the N-terminus of the predicted A. niger protein contains a Gal4-type Zn(2)-Cys(6) DNA-binding domain.; Title: strong similarity to hypothetical transcription factor CAB91400.2 - Neurospora crassa; uncharacterized protein 3176376 4979860 An02g13200 Aspergillus niger uncharacterized protein XP_001400451.3 3173706 D 5061 CDS An02g13210 4979861 complement(join(3176544..3177130,3177179..3177569,3177616..3177959,3178011..3178071,3178120..3178327,3178608..3179113)) IV 1 NT_166519.1 Function: human LUCA15 specifically bound poly(G) RNA homopolymers in vitro and its ectopic expression suppressed the cell growth.; Regulation: LUCA15 is one of the down-regulated genes in ras-transformed cells.; Title: similarity to RNA-binding tumour suppressor LUCA15 - Homo sapiens; See PMID 10353602; See PMID 11029660; uncharacterized protein 3179113 4979861 An02g13210 Aspergillus niger uncharacterized protein XP_059605167.1 3176544 R 5061 CDS An02g13220 4979862 join(3180466..3180517,3180577..3182447) IV 1 NT_166519.1 Catalytic activity: Lysophospholipases convert 2-lysophosphatidylcholine + H(2)O to glycerophosphocholine + a fatty acid anion.; Function: P. notatum phospholipase B has lysophospholipase and phospholipase B activity, however by endogenous proteolytic modification, its phospholipase B activity is lost almost completely, whereas its lysophospholipase activity remains unchanged.; Remark: similar phospholipase B proteins from C. albica and A. fumigatus are secreted virulence factors.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger EST an_1710.; Title: strong similarity to lysophospholipase phospholipase B - Penicillium notatum; See PMID 9580028; See PMID 10627494; See PMID 1722456; uncharacterized protein 3182447 4979862 An02g13220 Aspergillus niger uncharacterized protein XP_001400453.1 3180466 D 5061 CDS An02g13230 84590546 complement(join(3182751..3183046,3183100..3183345,3183425..3183577,3183636..3183761,3183829..3183910)) IV 1 NT_166519.1 Remark: all other members of this family are 3 fold longer.; Similarity: to proteins of the tenascin family.; Title: weak similarity to tenascin-X Tnx - Mus musculus; uncharacterized protein 3183910 84590546 An02g13230 Aspergillus niger uncharacterized protein XP_059605168.1 3182751 R 5061 CDS An02g13240 4979864 complement(join(3184649..3185180,3185235..3185994,3186062..3186533)) IV 1 NT_166519.1 Catalytic activity: hydrolysis of terminal,non-reducing 1,4-linked alpha-D-glucose residues with release of alpha-D-glucose.; Pathway: galactose metabolism; starch and sucrose metabolism.; Remark: the described cluster in A. parasiticus has no similar well-defined sugar gene cluster has been reported so far in any other related Aspergillus species such as A. flavus, A. nidulans, A. sojae, A. niger, A. oryzae and A. fumigatus.; Remark: this single entry covers a group of enzymes whose specificity is directed mainly towards the exohydrolysis of 1,4-alpha-glucosidic linkages, and that hydrolyse oligosaccharides rapidly, relative to polysaccharides, which are hydrolysed relatively slowly, or not at all.; Title: strong similarity to alpha-1-6-glucosidase glcA - Aspergillus parasiticus; See PMID 10978525; uncharacterized protein 3186533 4979864 An02g13240 Aspergillus niger uncharacterized protein XP_001400455.1 3184649 R 5061 CDS An02g13250 4979865 complement(join(3187961..3188194,3188243..3188866)) IV 1 NT_166519.1 Remark: water transport in highly water-permeable membranes is conducted by water-selective pores namely,water channels. AQP3 in rat may function as a water and urea exit mechanism in antidiuresis in collecting duct cells.; Similarity: to the aquaporins of different eukaryotes.; Title: strong similarity to water channel protein aquaporin 3 AQP3 - Rattus norvegicus; See PMID 8063828; See PMID 7517548; See PMID 7526388; uncharacterized protein 3188866 4979865 An02g13250 Aspergillus niger uncharacterized protein XP_001400456.1 3187961 R 5061 CDS An02g13260 4979866 complement(join(3189405..3189467,3189511..3189912,3190197..3190237,3190530..3190584)) IV 1 NT_166519.1 hypothetical protein 3190584 4979866 An02g13260 Aspergillus niger hypothetical protein XP_059605169.1 3189405 R 5061 CDS An02g13270 4979867 join(3191010..3191303,3191361..3191404,3191451..3191638,3191697..3191794,3191843..3191932,3191991..3192133,3192184..3192322,3192378..3192489,3192571..3192724,3192777..3192939) IV 1 NT_166519.1 Catalytic activity: Benzoate + NADPH + O2 = 4-Hydroxybenzoate + NADP+ + H2O.; Induction: bphA of A. niger is inducible by benzoate.; Pathway: phenylalanine metabolism.; Remark: the A. niger protein requires Fe2+ and tetrahydrobiopterin.; Similarity: to the cytochrome P450 superfamily.; Title: strong similarity to benzoate 4-monooxygenase cytochrome P450 53 bphA - Aspergillus niger; endoplasmatic reticulum; See PMID 2250647; uncharacterized protein 3192939 4979867 An02g13270 Aspergillus niger uncharacterized protein XP_059605170.1 3191010 D 5061 CDS An02g13280 4979868 complement(3193155..3193886) IV 1 NT_166519.1 Similarity: the ORF shows strong similarity to another A. niger protein.; Title: similarity to hypothetical protein AAN59045.1 - Streptococcus mutans; uncharacterized protein 3193886 4979868 An02g13280 Aspergillus niger uncharacterized protein XP_001400459.1 3193155 R 5061 CDS An02g13290 4979869 join(3195013..3195077,3195128..3196457) IV 1 NT_166519.1 Function: ARGR2 of S. cerevisiae is a regulator of arginine-responsive genes together with ARG80 and ARG82.; Remark: ARGR2 of S. cerevisiae is also called ARG81.; Similarity: only the N-terminus of fungal transcriptional regulatory proteins containing the zinc-finger domain is similar to the ORF sequence.; Title: similarity to transcription factor Arg81 -Saccharomyces cerevisiae; See PMID 7985419; See PMID 10436161; See PMID 789352; uncharacterized protein 3196457 4979869 An02g13290 Aspergillus niger uncharacterized protein XP_001400460.1 3195013 D 5061 CDS An02g13300 10098273 join(3196939..3198617,3198667..3198918,3198972..3199085,3199160..3199838) IV 1 NT_166519.1 Title: similarity to hypothetical protein ID880 -Bradyrhizobium japonicum; uncharacterized protein 3199838 10098273 An02g13300 Aspergillus niger uncharacterized protein XP_003188625.2 3196939 D 5061 CDS An02g13310 4979871 complement(join(3200248..3200804,3200892..3201031,3201078..3201281,3201348..3201988,3202055..3202339,3202378..3202479)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein Rv0976c - Mycobacterium tuberculosis; uncharacterized protein 3202479 4979871 An02g13310 Aspergillus niger uncharacterized protein XP_059605171.1 3200248 R 5061 CDS An02g13320 4979872 join(3203132..3204076,3204137..3204925) IV 1 NT_166519.1 Remark: the homolog proteins match only with the N-terminal parts, and are shorter.; Title: similarity to gentisate 1,2-dioxygenase xlnE - Pseudomonas alcaligenes; See PMID 10049846; uncharacterized protein 3204925 4979872 An02g13320 Aspergillus niger uncharacterized protein XP_059605172.1 3203132 D 5061 CDS An02g13330 4979873 complement(join(3205001..3205551,3205631..3205688,3205780..3206825,3206890..3207185,3207250..3207377,3207428..3207475)) IV 1 NT_166519.1 Remark: Schizosaccharomyces pombe thi1 gene acts as an activator of several thiamine-repressible genes which are involved in the control of thiamine metabolism.; Similarity: contains a zn(2)-cys(6), fungal-type binuclear cluster domain.; Title: similarity to thiamine repressible gene thi1p - Schizosaccharomyces pombe; See PMID 8088540; uncharacterized protein 3207475 4979873 An02g13330 Aspergillus niger uncharacterized protein XP_059605173.1 3205001 R 5061 CDS An02g13340 4979874 complement(3208469..3210193) IV 1 NT_166519.1 Remark: strong similarity to BAA-BEST1 from Hordeum sp. patent WO9902703-A1.; Similarity: also strong similarity to para-nitrobenzyl esterases and acetylcholinesterases.; Title: strong similarity to fumonisin esterase BAA-BEST1 from patent WO9902703-A1 - Hordeum sp.; uncharacterized protein 3210193 4979874 An02g13340 Aspergillus niger uncharacterized protein XP_001400465.1 3208469 R 5061 CDS An02g13350 4979875 3211614..3212156 IV 1 NT_166519.1 Remark: molybdenum cofactor (Moco) biosynthesis is an evolutionarily conserved pathway present in eubacteria,archaea and eukaryotes, including humans.; Similarity: to molybdopterin-converting factor chain 2.; Title: strong similarity to molybdopterin synthase large subunit cnxH - Aspergillus nidulans; See PMID 10383438; See PMID 11135669; uncharacterized protein 3212156 4979875 An02g13350 Aspergillus niger uncharacterized protein XP_001400466.1 3211614 D 5061 CDS An02g13360 4979876 complement(join(3212299..3212420,3212500..3212824,3212904..3213350)) IV 1 NT_166519.1 Remark: the yeast nuclear SCO1 gene is required for the accumulation of subunits 1 and 2 of cytochrome c oxidase complex. Thought to play a role in either mitochondrial copper transport or insertion of copper into the active site of cox.; Similarity: the protein belongs to the SCO1/2 protein family.; Title: strong similarity to assembly factor of cytochrome c oxidase Sco1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 11086158; See PMID 2543907; uncharacterized protein 3213350 4979876 An02g13360 Aspergillus niger uncharacterized protein XP_001400467.1 3212299 R 5061 CDS An02g13370 4979877 complement(join(3213991..3216302,3216634..3216672,3217062..3217075,3217262..3217302)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein 7C14.100 - Neurospora crassa; uncharacterized protein 3217302 4979877 An02g13370 Aspergillus niger uncharacterized protein XP_059605174.1 3213991 R 5061 CDS An02g13380 4979878 3220577..3222271 IV 1 NT_166519.1 Remark: due to repetitiv sequences it is only weak similarity.; Title: weak similarity to gastric mucin clone PGM-2A - Sus scrofa; See PMID 7506218; uncharacterized protein 3222271 4979878 An02g13380 Aspergillus niger uncharacterized protein XP_059605175.1 3220577 D 5061 CDS An02g13390 4979879 complement(3223899..3224534) IV 1 NT_166519.1 Remark: caYAE1 is used to produce e. g. recombinant protein and DNA vaccination, for treating candidosis.; Remark: similarity to caYAE1 protein YAE1 from Candida albicans patent EP844307-A1.; Title: similarity to caYAE1 protein YAE1 from patent EP844307-A1 - Candida albicans; uncharacterized protein 3224534 4979879 An02g13390 Aspergillus niger uncharacterized protein XP_001400470.1 3223899 R 5061 CDS An02g13400 4979880 3225210..3226088 IV 1 NT_166519.1 Remark: weak similarity to O antigen abe gene protein from Salmonella enterica patent WO9850531-A1.; Title: weak similarity to antigen abe from patent WO9850531-A1 - Salmonella enterica; uncharacterized protein 3226088 4979880 An02g13400 Aspergillus niger uncharacterized protein XP_001400471.1 3225210 D 5061 CDS An02g13410 4979881 complement(join(3226758..3226823,3226927..3226981,3227139..3227369,3227426..3229176)) IV 1 NT_166519.1 Remark: AT-1 protein functions as an Ac-CoA transporter, and may play a key role in acetylation processes of gangliosides.; Remark: the protein seems approximately 200 aa to short.; Remark: the protein shows also similarity to Acetyl-coenzyme A transporter (AT) protein from Homo sapiens patent US5851788-A and WO9833816-A1.; Title: similarity to acetyl-coenzyme A transporter AT-1 - Homo sapiens; See PMID 9096318; uncharacterized protein 3229176 4979881 An02g13410 Aspergillus niger uncharacterized protein XP_001400472.3 3226758 R 5061 CDS An02g13420 4979882 join(3229825..3229873,3229944..3230965) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein EAA60070.1 - Aspergillus nidulans; uncharacterized protein 3230965 4979882 An02g13420 Aspergillus niger uncharacterized protein XP_059605176.1 3229825 D 5061 CDS An02g13430 4979883 complement(join(3231414..3232064,3232113..3233015)) IV 1 NT_166519.1 Remark: all found homology proteins are longer.; Title: weak similarity to trichohyalin TRHY - Homo sapiens; See PMID 7685034; uncharacterized protein 3233015 4979883 An02g13430 Aspergillus niger uncharacterized protein XP_001400474.1 3231414 R 5061 CDS An02g13440 4979884 complement(3234390..3235271) IV 1 NT_166519.1 Remark: the protein shows strong similarity to carboxylic ester hydrolases, the substrate specifity is unkown cause it shows both similarity to carboxylesterases and to triacylglycerol lipases.; Title: strong similarity to lipase LipP -Pseudomonas sp.; See PMID 9464382; uncharacterized protein 3235271 4979884 An02g13440 Aspergillus niger uncharacterized protein XP_001400475.1 3234390 R 5061 CDS An02g13450 4979885 complement(join(3236326..3236475,3236720..3236745,3236843..3238551,3238644..3238717,3238766..3238839,3239071..3239311,3239344..3239356,3239662..3239759)) IV 1 NT_166519.1 Title: weak similarity to protein CAP59 -Cryptococcus neoformans; uncharacterized protein 3239759 4979885 An02g13450 Aspergillus niger uncharacterized protein XP_001400476.3 3236326 R 5061 CDS An02g13460 4979886 complement(join(3244012..3245139,3245200..3245616)) IV 1 NT_166519.1 Function: pcpl3 of s. cerevisiae mediates the active transport of purines and cytosine.; Title: strong similarity to purine-cytosine permease pcpl3 - Kluyveromyces marxianus; See PMID 10943566; uncharacterized protein 3245616 4979886 An02g13460 Aspergillus niger uncharacterized protein XP_001400477.1 3244012 R 5061 CDS An02g13470 4979887 join(3247951..3248042,3248112..3248178,3248246..3248398,3248455..3248516,3248570..3248867,3248935..3249531) IV 1 NT_166519.1 Title: similarity to hypothetical protein CAD60573.1 - Podospora anserina; uncharacterized protein 3249531 4979887 An02g13470 Aspergillus niger uncharacterized protein XP_001400478.1 3247951 D 5061 CDS An02g13480 4979888 complement(join(3252232..3253115,3253173..3253229,3253277..3253470,3253520..3253529,3253588..3253663,3253709..3253798)) IV 1 NT_166519.1 Title: similarity to hypothetical protein B2J23.40 -Neurospora crassa; uncharacterized protein 3253798 4979888 An02g13480 Aspergillus niger uncharacterized protein XP_059605177.1 3252232 R 5061 CDS An02g13490 4979889 join(3254809..3254927,3254981..3255067,3255126..3255206,3255271..3255838,3255913..3256203) IV 1 NT_166519.1 Function: A. parasiticus norA has norsolorinic acid reductase (NOR) activity.; Function: norA of A. parasiticus is genomically localized within the aflatoxin biosynthetic cluster and has been implicated in aflatoxin biosynthesis.; Induction: A. parasiticus norA mRNA and protein is present only when the fungus is grown in medium conductive to aflatoxin biosynthesis.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Title: strong similarity to norsolorinic acid reductase norA - Aspergillus parasiticus; See PMID 8593042; uncharacterized protein 3256203 4979889 An02g13490 Aspergillus niger uncharacterized protein XP_001400480.1 3254809 D 5061 CDS An02g13500 4979890 join(3256964..3257077,3257132..3257351,3257479..3257616,3257664..3259321) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein Mx - Anas platyrhynchos; See PMID 8100373; See PMID 9360386; uncharacterized protein 3259321 4979890 An02g13500 Aspergillus niger uncharacterized protein XP_059605178.1 3256964 D 5061 CDS An02g13510 4979891 join(3260062..3260245,3260296..3260483,3260550..3261344) IV 1 NT_166519.1 Similarity: the ORF encoded protein shows also strong similarity to the hypothetical proteins YIL083c (S. cerevisiae) and SPCC4B3. 18 (S. pombe).; Title: strong similarity to polypeptide SEQ ID NO:41022 from patent WO200171042-A2 - Drosophila melanogaster; uncharacterized protein 3261344 4979891 An02g13510 Aspergillus niger uncharacterized protein XP_059605179.1 3260062 D 5061 CDS An02g13520 4979892 join(3262569..3263570,3263602..3263955) IV 1 NT_166519.1 Title: similarity to hypothetical protein CAC41653.1 - Ustilago maydis; uncharacterized protein 3263955 4979892 An02g13520 Aspergillus niger uncharacterized protein XP_059605180.1 3262569 D 5061 CDS An02g13530 4979893 complement(join(3264694..3265028,3265077..3265162,3265219..3266078)) IV 1 NT_166519.1 Catalytic activity: chitin + H(2)O <=> chitosan + acetate.; Title: similarity to peptidoglycan N-acetylglucosamine deacetylase PgdA - Streptococcus pneumoniae; See PMID 10781617; uncharacterized protein 3266078 4979893 An02g13530 Aspergillus niger uncharacterized protein XP_059605181.1 3264694 R 5061 CDS An02g13540 4979894 complement(join(3266769..3267067,3267125..3267273,3267323..3267516,3267571..3267722,3267771..3267850,3267897..3268263,3268303..3268438,3268490..3268547,3268600..3268928)) IV 1 NT_166519.1 Function: the Ded1 protein from S. cerevisiae is a ATP-dependent RNA helicase and plays a role in translation initiation.; Remark: S. cerevisiae Ded1 is essential for cell viability.; Remark: alternate name for S. cerevisiae Ded1: Spp81 or YOR204W.; Similarity: the ORF encoded protein shows also strong similarity to the ATP-dependent RNA helicase DBP1 (YPL119C) from S. cerevisiae.; Title: strong similarity to ATP-dependent RNA helicase Ded1 - Saccharomyces cerevisiae; See PMID 9144215; See PMID 10364207; uncharacterized protein 3268928 4979894 An02g13540 Aspergillus niger uncharacterized protein XP_059605182.1 3266769 R 5061 CDS An02g13550 4979895 join(3270832..3271047,3271180..3271462,3271532..3272036,3272091..3272406) IV 1 NT_166519.1 Catalytic activity: ATP + pantothenate <=> ADP + D-4'-phosphopantothenate.; Pathway: the pantothenate kinase PanK from Emericella nidulans is involved in first step in coenzyme A (CoA) biosynthesis.; Title: strong similarity to pantothenate kinase panK - Aspergillus nidulans; See PMID 9890959; uncharacterized protein 3272406 4979895 An02g13550 Aspergillus niger uncharacterized protein XP_059605183.1 3270832 D 5061 CDS An02g13560 4979896 join(3274756..3274799,3275020..3275974) IV 1 NT_166519.1 Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: weak similarity to nucleolar protein gar2p -Schizosaccharomyces pombe; uncharacterized protein 3275974 4979896 An02g13560 Aspergillus niger uncharacterized protein XP_001400487.3 3274756 D 5061 CDS An02g13570 4979897 join(3276257..3276614,3276669..3276940,3277247..3277822) IV 1 NT_166519.1 Function: the human pig-C protein is involved in the first step of glycosylphosphatidylinositol synthesis which is the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol.; Remark: Glycosylphosphatidylinositol (GPI) protein anchors are ubiquitous in eukaryotic cells. GPI anchors are synthesized in the endoplasmic reticulum by actions of ten or more gene products. The first step of the biosynthesis,the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol.; Similarity: pig-C is the human Gpi2 (S. cerevisiae) homolog.; Title: strong similarity to protein involved in glycosylphosphatidylinositol biosynthesis pig-C - Homo sapiens; endoplasmatic reticulum; See PMID 8806613; See PMID 9463366; uncharacterized protein 3277822 4979897 An02g13570 Aspergillus niger uncharacterized protein XP_059605184.1 3276257 D 5061 CDS An02g13580 4979898 join(3278510..3278547,3278625..3278917,3278980..3279836) IV 1 NT_166519.1 Function: an endochitinase the catalyzes hydrolysis of the 1,4-beta-linkages of N-acetyl-D-glucosamine polymers of chitin.; Title: strong similarity to endochitinase from patent EP531218-A - Aphanocladium album; uncharacterized protein 3279836 4979898 An02g13580 Aspergillus niger uncharacterized protein XP_059605185.1 3278510 D 5061 CDS An02g13590 4979899 complement(join(3280335..3280624,3280693..3282107,3282276..3282440,3282489..3283982,3284046..>3284383)) IV 1 NT_166519.1 Function: Pseudomonas tolaasii is the causal agent of brown blotch disease of Agaricus bisporus. The PheN sensor regulator is responsible for the phenotypic switch from the smooth, pathogenic form (designated 1116S) to the rough non-pathogenic form (designated 1116R) of P. tolaasii.; Remark: N-terminally truncated ORF due to the end of contig.; Similarity: the PheN protein from Pseudomonas tolaasii has sensor and regulator domains. It belongs to the conserved family of two component bacterial sensor regulator proteins.; Title: strong similarity to two component sensor regulator PheN - Pseudomonas tolaasii [truncated ORF]; See PMID 7642492; See PMID 9282733; uncharacterized protein 3284383 4979899 An02g13590 Aspergillus niger uncharacterized protein XP_059605186.1 3280335 R 5061 CDS An02g13600 4979900 complement(join(3286187..3286856,3287004..3288045,3288123..3288309)) IV 1 NT_166519.1 Function: is involved in the uptake of histidinol and other cations.; Remark: alternate name for S. cerevisiae Hol1 is YNR055c.; Similarity: the ORF encoded protein shows also strong similarity to the major facilitator superfamily of transporters.; Title: strong similarity to the cation transporter Hol1 - Saccharomyces cerevisiae; See PMID 8955402; uncharacterized protein 3288309 4979900 An02g13600 Aspergillus niger uncharacterized protein XP_059600128.1 3286187 R 5061 CDS An02g13610 84590547 complement(join(3289639..3289701,3289806..3289994)) IV 1 NT_166519.1 hypothetical protein 3289994 84590547 An02g13610 Aspergillus niger hypothetical protein XP_059600129.1 3289639 R 5061 CDS An02g13620 4979902 3290608..3292179 IV 1 NT_166519.1 Title: weak similarity to hypothetical protein ORF-c18_019 - Sulfolobus solfataricus; uncharacterized protein 3292179 4979902 An02g13620 Aspergillus niger uncharacterized protein XP_001400493.1 3290608 D 5061 CDS An02g13630 4979903 join(3293036..3293410,3293461..3294576) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein CC0505 - Caulobacter crescentus; uncharacterized protein 3294576 4979903 An02g13630 Aspergillus niger uncharacterized protein XP_001400494.1 3293036 D 5061 CDS An02g13640 4979904 join(3295024..3295312,3295451..3295620,3295677..3296351) IV 1 NT_166519.1 Function: the Slg1 protein from S. cerevisiae is proposed to play a regulatory role in bud emergence or stationary phase.; Localization: Epitope-tagged Slg1p cofractionated with the plasma membrane.; Remark: alternate names for S. cerevisiae Slg1: Wsc3 or YOL105C.; Similarity: the similarities of the ORF encoded protein to some matching proteins are mainly based on repetitive structures.; Title: similarity to cell cycle relevant protein Slg1 - Saccharomyces cerevisiae; plasma membrane; See PMID 10660075; uncharacterized protein 3296351 4979904 An02g13640 Aspergillus niger uncharacterized protein XP_059600130.1 3295024 D 5061 CDS An02g13650 4979905 complement(join(3296602..3296719,3296801..3297083,3297164..3297278)) IV 1 NT_166519.1 hypothetical protein 3297278 4979905 An02g13650 Aspergillus niger hypothetical protein XP_059600131.1 3296602 R 5061 CDS An02g13660 84590548 complement(3298028..3299059) IV 1 NT_166519.1 Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: weak similarity to extracellular matrix protein papilin Ppn - Drosophila melanogaster; uncharacterized protein 3299059 84590548 An02g13660 Aspergillus niger uncharacterized protein XP_059600132.1 3298028 R 5061 CDS An02g13670 4979907 join(3300125..3300718,3300773..3301296,3301369..3301661,3301711..3301778) IV 1 NT_166519.1 Title: similarity to human secreted protein fragment from patent WO9909155-A1 - Homo sapiens; uncharacterized protein 3301778 4979907 An02g13670 Aspergillus niger uncharacterized protein XP_059600133.1 3300125 D 5061 CDS An02g13680 4979908 join(3303100..3303337,3303399..3304767,3304817..3305989,3306039..3306141) IV 1 NT_166519.1 Complex: a complex of the nuclear matrix proteins SRm160 and SRm300 functions as a coactivator of pre-mRNA splicing.; Function: the SRm160/300 splicing coactivator functions in splicing by promoting critical interactions between splicing factors bound to pre-mRNA, including snRNPs and SR family proteins.; Remark: SRM160 is a serine (S) and arginine (R)-rich protein.; Title: similarity to Ser/Arg-related nuclear matrix protein SRM160 - Homo sapiens; nucleus; See PMID 9531537; See PMID 10668804; uncharacterized protein 3306141 4979908 An02g13680 Aspergillus niger uncharacterized protein XP_001400499.1 3303100 D 5061 CDS An02g13690 84590549 complement(join(3306852..3306881,3306953..3307063)) IV 1 NT_166519.1 hypothetical protein 3307063 84590549 An02g13690 Aspergillus niger hypothetical protein XP_059600134.1 3306852 R 5061 CDS An02g13700 4979910 join(3307650..3310074,3310105..3310673) IV 1 NT_166519.1 Title: weak similarity to sterigmatocystin synthesis transcription regulator aflR - Aspergillus nidulans; uncharacterized protein 3310673 4979910 An02g13700 Aspergillus niger uncharacterized protein XP_059600135.1 3307650 D 5061 CDS An02g13710 4979911 complement(join(3312054..3312583,3312659..3312956)) IV 1 NT_166519.1 Title: weak similarity to Slg1 - Saccharomyces cerevisiae; uncharacterized protein 3312956 4979911 An02g13710 Aspergillus niger uncharacterized protein XP_001400502.1 3312054 R 5061 CDS An02g13720 84590550 join(3313314..3313498,3313587..3313818) IV 1 NT_166519.1 hypothetical protein 3313818 84590550 An02g13720 Aspergillus niger hypothetical protein XP_059600136.1 3313314 D 5061 CDS An02g13730 84590551 complement(join(3313914..3314006,3314097..3314161,3314231..3314340,3314594..3314796)) IV 1 NT_166519.1 hypothetical protein 3314796 84590551 An02g13730 Aspergillus niger hypothetical protein XP_059600137.1 3313914 R 5061 CDS An02g13740 4979914 join(3314858..3315201,3315249..3316546,3316600..3316694) IV 1 NT_166519.1 Catalytic activity: release of a C-terminal amino acid from a peptide in which glycine is the penultimate amino acid.; Pathway: yscS is a member of the peptidases in S. cerevisiae involved in nitrogen metabolism.; Repression: transcriptional repression of yscS in yeast cells grown on rich nitrogen sources.; Similarity: yscS belongs to peptidase family M20A.; Title: strong similarity to Gly-X carboxypeptidase precursor Yscs - Saccharomyces cerevisiae; vacuole; See PMID 2026161; See PMID 7700231; uncharacterized protein 3316694 4979914 An02g13740 Aspergillus niger uncharacterized protein XP_001400505.1 3314858 D 5061 CDS An02g13750 4979915 complement(join(3317220..3317298,3317357..3317492,3317546..3317689,3317741..3317943,3317997..3318580,3318633..3319075,3319148..3319440,3319508..3319701)) IV 1 NT_166519.1 Catalytic activity: glutamine is hydrolysed to glutamate and ammonium.; Remark: purified glutaminase gtaA catalyses the hydrolysis not only of L-glutamine but also of D-glutamine.; Title: strong similarity to glutaminase A gtaA -Aspergillus oryzae; See PMID 10952006; uncharacterized protein 3319701 4979915 An02g13750 Aspergillus niger uncharacterized protein XP_001400506.1 3317220 R 5061 CDS An02g13760 84590552 join(3320289..3320464,3320583..3320630,3320729..3320754,3320882..3320966,3321055..3321298,3321388..3321498,3321691..3321750) IV 1 NT_166519.1 hypothetical protein 3321750 84590552 An02g13760 Aspergillus niger hypothetical protein XP_059600138.1 3320289 D 5061 CDS An02g13770 4979917 complement(join(3322344..3323902,3324085..3324199,3324275..3324358)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein BAC67939.1 - Streptomyces avermitilis; uncharacterized protein 3324358 4979917 An02g13770 Aspergillus niger uncharacterized protein XP_059600139.1 3322344 R 5061 CDS An02g13780 84590553 join(3328606..3328688,3328953..3329100,3329197..3329323,3329512..3329627) IV 1 NT_166519.1 Title: weak similarity to hypothetical protein F22O6.70 - Arabidopsis thaliana; uncharacterized protein 3329627 84590553 An02g13780 Aspergillus niger uncharacterized protein XP_059600140.1 3328606 D 5061 CDS An02g13790 4979919 complement(join(3330449..3330794,3330927..3331176,3331297..3331571,3331631..3332163)) IV 1 NT_166519.1 Complex: a purified Drosophila septin complex comprised of the three septin polypeptides Pnut, Sep2, and Sep1 forms filaments and exhibits GTPase activity.; Function: septin proteins such as Sep1 are necessary for cytokinesis in Drosophila.; Similarity: Sep1 is a member of the GTPase superfamily.; Title: similarity to septin protein Sep1 -Drosophila melanogaster; See PMID 9751888; See PMID 8636235; uncharacterized protein 3332163 4979919 An02g13790 Aspergillus niger uncharacterized protein XP_059600141.1 3330449 R 5061 CDS An02g13800 4979920 complement(join(3334972..3335326,3335423..3335584,3335637..3335693,3335748..3336078,3336131..3336260)) IV 1 NT_166519.1 Similarity: the ORF shows similarity to an A. niger sequence clone 2457. The sequence deviates in overall length as well as in two positions in the matching region from the sequence of the genomic DNA.; Title: strong similarity to hypothetical membrane protein YPR157w - Saccharomyces cerevisiae; uncharacterized protein 3336260 4979920 An02g13800 Aspergillus niger uncharacterized protein XP_001400511.3 3334972 R 5061 CDS An02g13810 4979921 complement(join(3337203..3337516,3337581..3337638,3337701..3337833,3337919..3338029,3338115..3338127,3338337..3338343)) IV 1 NT_166519.1 Function: dodA encodes a type of aromatic ring-cleaving dioxygenase involved in betalain biosynthesis in Amanita muscaria.; Induction: regulation occurs at the transcriptional level; the mRNA accumulates to high levels only in the coloured cap tissue.; Title: similarity to DOPA-dioxygenase dodA - Amanita muscaria; See PMID 9341673; uncharacterized protein 3338343 4979921 An02g13810 Aspergillus niger uncharacterized protein XP_001400512.3 3337203 R 5061 CDS An02g13820 4979922 complement(join(3338950..3340099,3340163..3340296)) IV 1 NT_166519.1 Title: weak similarity to tight junction protein ZO-1 - Hydra vulgaris; uncharacterized protein 3340296 4979922 An02g13820 Aspergillus niger uncharacterized protein XP_059600142.1 3338950 R 5061 CDS An02g13830 4979923 join(3340712..3340933,3341005..3341224,3341313..3341734) IV 1 NT_166519.1 Title: similarity to hypothetical protein CAE76380.1 - Neurospora crassa; uncharacterized protein 3341734 4979923 An02g13830 Aspergillus niger uncharacterized protein XP_001400514.1 3340712 D 5061 CDS An02g13840 4979924 complement(join(3342005..3342182,3342242..3342475,3342561..3342659,3342738..3342756,3342832..3342869,3342936..3342949)) IV 1 NT_166519.1 Complex: S9 is a protein of the cytosolic small ribosomal (40S)-subunit.; Function: S9 is involved in protein biosynthesis.; Similarity: S9 belongs to the S4P family of ribosomal proteins.; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S9 - Homo sapiens; cytoplasm; See PMID 7772601; 40S ribosomal protein uS4 3342949 4979924 An02g13840 Aspergillus niger 40S ribosomal protein uS4 XP_001400515.1 3342005 R 5061 CDS An02g13850 4979925 join(3343221..3343256,3343333..3343400,3343472..3343519,3343635..3343959) IV 1 NT_166519.1 Complex: URP1 is a protein of the cytosolic large ribosomal (60S)-subunit.; Function: URP1 is involved in protein biosynthesis.; Similarity: URP1 is a homolog of rat ribosomal protein gene L21.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit Urp1 - Saccharomyces cerevisiae; cytoplasm; See PMID 7871891; See PMID 8428379; 60S ribosomal protein eL21 3343959 4979925 An02g13850 Aspergillus niger 60S ribosomal protein eL21 XP_001400516.1 3343221 D 5061 CDS An02g13860 4979926 join(3346394..3346979,3347031..3347201,3347262..3350575) IV 1 NT_166519.1 Title: weak similarity to neurofilament triplet H protein NF-H - Rattus norvegicus; uncharacterized protein 3350575 4979926 An02g13860 Aspergillus niger uncharacterized protein XP_059600143.1 3346394 D 5061 CDS An02g13870 4979927 complement(join(3350903..3350971,3351009..3351052,3351168..3351360,3351755..3351833,3351872..3352026,3352091..3353247,3353305..3353339,3353391..3353455,3353570..3353597,3353684..3353757)) IV 1 NT_166519.1 Remark: silencing is an epigenetic form of transcriptional regulation whereby genes are heritably, but not necessarily permanently, inactivated.; Similarity: SAS2 bears similarities to known protein acetyltransferases.; Similarity: SAS2 belongs to the MYST family and members of this family are implicated in acute myeloid leukemia (MOZ), transcriptional silencing in yeast (SAS2 and YBF2/SAS3), HIV Tat interaction in humans (Tip60).; Title: similarity to transcription silencing protein Sas2 - Saccharomyces cerevisiae; See PMID 8782818; See PMID 9093847; uncharacterized protein 3353757 4979927 An02g13870 Aspergillus niger uncharacterized protein XP_001400518.3 3350903 R 5061 CDS An02g13880 4979928 complement(join(3354302..3356276,3356338..3356678,3356751..3356784,3356841..3356866)) IV 1 NT_166519.1 Function: cdc5 might encode a transcription factor whose activity is required for cell cycle progression and growth during G2.; Phenotype: a cdc5 mutant arrests with a 2N DNA content and a single interphase nucleus.; Similarity: cdc5 contains a region sharing significant homology with the DNA binding domain of the myb family of transcription factors.; Title: strong similarity to myb-related protein cdc5p - Schizosaccharomyces pombe; See PMID 8313892; uncharacterized protein 3356866 4979928 An02g13880 Aspergillus niger uncharacterized protein XP_001400519.1 3354302 R 5061 CDS An02g13890 4979929 join(3357236..3357369,3357442..3358380,3358435..3358651) IV 1 NT_166519.1 Remark: the matching protein is a Jun N-terminal protein kinase (JNK3) binding protein.; Title: similarity to JNK3 binding protein amino acid sequence #8 from patent WO200031132-A1 - Mus sp.; uncharacterized protein 3358651 4979929 An02g13890 Aspergillus niger uncharacterized protein XP_001400520.1 3357236 D 5061 CDS An02g13900 4979930 join(3359052..3359374,3359443..3360049) IV 1 NT_166519.1 Function: RNH70 is involved in DNA replication and RNA processing.; Phenotype: deletion of RNH70 from the yeast genome did not result in any serious phenotype under the conditions tested.; Title: similarity to ribonuclease Rnh70 -Saccharomyces cerevisiae; nucleus; See PMID 10359084; See PMID 10669875; uncharacterized protein 3360049 4979930 An02g13900 Aspergillus niger uncharacterized protein XP_001400521.1 3359052 D 5061 CDS An02g13910 4979931 join(3361635..3361710,3361815..3362477,3362545..3362789) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein SPBP4H10.20 - Schizosaccharomyces pombe; uncharacterized protein 3362789 4979931 An02g13910 Aspergillus niger uncharacterized protein XP_001400522.1 3361635 D 5061 CDS An02g13920 4979932 join(3363121..3363172,3363254..3363954) IV 1 NT_166519.1 Catalytic activity: ubiquitin C-terminal thiolester + H(2)O = ubiquitin + a thiol.; Complex: the interaction between YUH1 and the yeast ubiquitin protein has been studied by heteronuclear multidimensional NMR spectroscopy.; Function: YUH1, a cysteine protease that catalyzes the removal of ubiquitin C-terminal adducts, is important for the generation of monomeric ubiquitin.; Remark: YUH1 acts on esters formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin.; Remark: the release of ubiquitin from attachment to other proteins and adducts is critical for ubiquitin biosynthesis, proteasomal degradation and other cellular processes.; Similarity: YUH1 is member of the UCH (ubiquitin C-terminal hydrolase) family of enzymes.; Title: strong similarity to ubiquitin thiolesterase Yuh1 - Saccharomyces cerevisiae; cytoplasm; See PMID 10406793; See PMID 10413498; uncharacterized protein 3363954 4979932 An02g13920 Aspergillus niger uncharacterized protein XP_001400523.1 3363121 D 5061 CDS An02g13930 84590554 complement(<3364934..3365446) IV 1 NT_166519.1 Remark: the ORF is C-terminally truncated due to end of contig.; hypothetical protein [truncated ORF] 3365446 84590554 An02g13930 Aspergillus niger hypothetical protein [truncated ORF] XP_059605706.1 3364934 R 5061 CDS An02g13940 4979934 complement(join(3366225..3369594,3369667..3369905)) IV 1 NT_166519.1 Function: SPBP35G2. 14 of S. pombe is similar to PUF proteins of S. cerevisiae which are thought to be involved in the regulation of mRNA stability.; Similarity: contains a RNA recognition motif (RRM) and 5 pumilio-family (PUF) RNA-binding repeats.; Title: strong similarity to hypothetical RNA-binding protein CAA18887.1 - Schizosaccharomyces pombe; uncharacterized protein 3369905 4979934 An02g13940 Aspergillus niger uncharacterized protein XP_001400525.3 3366225 R 5061 CDS An02g13950 84590555 join(3370090..3370130,3370180..3370236,3370283..3370335,3370431..3370568,3370854..3370942) IV 1 NT_166519.1 Title: weak similarity to hypothetical protein OSJNBa0026A15.6 - Oryza sativa; uncharacterized protein 3370942 84590555 An02g13950 Aspergillus niger uncharacterized protein XP_059605707.1 3370090 D 5061 CDS An02g13960 84590556 complement(join(3371299..3371433,3371531..3371604,3371681..3371737,3371888..3371952,3372098..3372192,3372314..3372401,3372585..3372685)) IV 1 NT_166519.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 3372685 84590556 An02g13960 Aspergillus niger uncharacterized protein XP_059605708.1 3371299 R 5061 CDS An02g13970 4979937 join(3373177..3375079,3375145..3375599) IV 1 NT_166519.1 Title: weak similarity to hypothetical glutamate-rich coiled-coil protein CAB87375.1 -Schizosaccharomyces pombe; uncharacterized protein 3375599 4979937 An02g13970 Aspergillus niger uncharacterized protein XP_001400528.1 3373177 D 5061 CDS An02g13980 10098275 complement(join(3376942..3377772,3377835..3377862,3377945..3378128,3378187..3378520,3378579..3378651,3378731..3378882)) IV 1 NT_166519.1 Phenotype: Disruption of Tri4 resulted in the loss of production of both trichothecenes and apotrichodiol and the accumulation of the unoxygenated pathway intermediate trichodiene.; Remark: Trichothecenes are strong inhibitors of protein synthesis in mammalian cells.; Remark: an alternate name for the F. sporotrichioides trichodiene oxygenase is TRI4.; Remark: the F. sporotrichioides trichodiene oxygenase is part of the fungal trichothecenes and apotrichodiol biosythesis.; Title: strong similarity to trichodiene oxygenase cytochrome P450 CYP58 - Fusarium sporotrichioides; See PMID 7651333; uncharacterized protein 3378882 10098275 An02g13980 Aspergillus niger uncharacterized protein XP_059605709.1 3376942 R 5061 CDS An02g13990 84590557 join(3379255..3379348,3379510..3379691,3379787..3380005,3380057..3380162,3380240..3380358) IV 1 NT_166519.1 hypothetical protein 3380358 84590557 An02g13990 Aspergillus niger hypothetical protein XP_059605710.1 3379255 D 5061 CDS An02g14000 84590558 complement(join(3380695..3380803,3380918..3381036,3381123..3381189,3381279..3381368,3381512..3381532,3381785..3381881,3381980..3382226,3382301..3382354,3382447..3382473)) IV 1 NT_166519.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 3382473 84590558 An02g14000 Aspergillus niger uncharacterized protein XP_059605711.1 3380695 R 5061 CDS An02g14005 84590559 3382610..3383002 IV 1 NT_166519.1 hypothetical protein 3383002 84590559 An02g14005 Aspergillus niger hypothetical protein XP_059605712.1 3382610 D 5061 CDS An02g14010 4979942 join(3383257..3383462,3383627..3383686,3383835..3384567) IV 1 NT_166519.1 hypothetical protein 3384567 4979942 An02g14010 Aspergillus niger hypothetical protein XP_003188597.1 3383257 D 5061 CDS An02g14020 84590560 complement(join(3385617..3385753,3385794..3385889,3385967..3386086,3386178..3386258,3386349..3386383,3386554..3386623,3386696..3386786,3386889..3386921)) IV 1 NT_166519.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 3386921 84590560 An02g14020 Aspergillus niger uncharacterized protein XP_059605713.1 3385617 R 5061 CDS An02g14030 84590561 join(3387326..3387553,3387584..3387790) IV 1 NT_166519.1 hypothetical protein 3387790 84590561 An02g14030 Aspergillus niger hypothetical protein XP_059605714.1 3387326 D 5061 CDS An02g14040 4979945 complement(join(3388013..3388129,3388182..3388334)) IV 1 NT_166519.1 hypothetical protein 3388334 4979945 An02g14040 Aspergillus niger hypothetical protein XP_001400536.1 3388013 R 5061 CDS An02g14050 84590562 complement(join(3389978..3390319,3390518..3390685,3390732..3390803,3390857..3390907)) IV 1 NT_166519.1 hypothetical protein 3390907 84590562 An02g14050 Aspergillus niger hypothetical protein XP_059605715.1 3389978 R 5061 CDS An02g14060 84590563 join(3391587..3391757,3391956..3392115,3392181..3392390,3392726..3392841,3392898..3393140) IV 1 NT_166519.1 Title: questionable ORF; uncharacterized protein 3393140 84590563 An02g14060 Aspergillus niger uncharacterized protein XP_059605716.1 3391587 D 5061 CDS An02g14070 4979948 join(3393612..3393655,3393736..3394018) IV 1 NT_166519.1 Similarity: the ORF shows strong similarity to the A. niger EST an_2818.; Title: weak similarity to hypothetical protein encoded by An11g01490 - Aspergillus niger; uncharacterized protein 3394018 4979948 An02g14070 Aspergillus niger uncharacterized protein XP_001400539.1 3393612 D 5061 CDS An02g14080 4979949 complement(join(3395351..3395477,3395558..3397155)) IV 1 NT_166519.1 Catalytic activity: the T. aquaticus asparaginyl-tRNA-synthetase converts ATP and L-asparagine and tRNA(Asn) to AMP and diphosphate and L-asparaginyl-tRNA(Asn).; Remark: the T. aquaticus asparaginyl-tRNA-synthetase is remarkably thermostable and retains 50% of its initial tRNA aminoacylation activity after 1 h of incubation at 90 degrees C or 21 h at 85 degrees C.; Title: strong similarity to asparagine--tRNA ligase ASNS - Thermus aquaticus; See PMID 8706760; uncharacterized protein 3397155 4979949 An02g14080 Aspergillus niger uncharacterized protein XP_001400540.1 3395351 R 5061 CDS An02g14090 84590564 complement(join(3397586..3397726,3397820..3397861,3397932..3398027,3398076..3398254,3398302..3398385,3398657..3398758,3399204..3399284,3399418..3399493)) IV 1 NT_166519.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 3399493 84590564 An02g14090 Aspergillus niger uncharacterized protein XP_059605717.1 3397586 R 5061 CDS An02g14100 4979951 3399845..3402346 IV 1 NT_166519.1 Function: TIA-1 is a translational silencer that selectively regulates the expression of TNF-alpha.; Function: the M. musculus TIA-1 belongs to a family of RNA recognition motif (RRM) proteins which possess four RRM-type (PF00076) RNA binding domains (aa 192-258, 283-358, 417-483, 508-574).; Remark: the M. musculus TIA-1 has been implicated as effector of apoptotic cell death.; Title: similarity to cDNA RNA-binding protein TIA-1 - Mus musculus; See PMID 8871565; See PMID 10921895; uncharacterized protein 3402346 4979951 An02g14100 Aspergillus niger uncharacterized protein XP_001400542.1 3399845 D 5061 CDS An02g14110 4979952 join(3403247..3403313,3403447..3404787,3404858..3405066) IV 1 NT_166519.1 hypothetical protein 3405066 4979952 An02g14110 Aspergillus niger hypothetical protein XP_001400543.1 3403247 D 5061 CDS An02g14130 84590565 complement(join(3424278..3424481,3424544..3424546)) IV 1 NT_166519.1 hypothetical protein 3424546 84590565 An02g14130 Aspergillus niger hypothetical protein XP_059605718.1 3424278 R 5061 CDS An02g14140 84590566 complement(join(3425305..3425334,3425471..3425523,3425674..3425710,3425752..3425872,3425947..3426063,3426098..3426123,3426251..3426262)) IV 1 NT_166519.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 3426262 84590566 An02g14140 Aspergillus niger uncharacterized protein XP_059605719.1 3425305 R 5061 CDS An02g14150 84590567 join(3427120..3427353,3427447..3427537,3427581..3427648) IV 1 NT_166519.1 hypothetical protein 3427648 84590567 An02g14150 Aspergillus niger hypothetical protein XP_059605720.1 3427120 D 5061 CDS An02g14160 10098055 complement(join(3429028..3429061,3429111..3429223,3429278..3429684,3429743..3429992,3430051..3430494,3430594..3430736,3430919..3431198,3431277..3432724,3432860..3433004)) IV 1 NT_166519.1 Function: the C. neoformans AP59 gene is required for capsule formation which is a crucial step in the pathogenicity of Cryptococcus neoformans.; Remark: the similarity of the predicted A. niger protein is restricted to the N-terminal half of the protein.; Title: similarity to protein CAP59 - Cryptococcus neoformans; See PMID 8007987; uncharacterized protein 3433004 10098055 An02g14160 Aspergillus niger uncharacterized protein XP_059605721.1 3429028 R 5061 CDS An02g14170 4979957 3433664..3434254 IV 1 NT_166519.1 Title: weak similarity to hypothetical protein all7165 - Nostoc sp.; uncharacterized protein 3434254 4979957 An02g14170 Aspergillus niger uncharacterized protein XP_001400548.1 3433664 D 5061 CDS An02g14180 84590568 complement(join(3434569..3434685,3434835..3434959,3435043..3435112,3435264..3435377)) IV 1 NT_166519.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 3435377 84590568 An02g14180 Aspergillus niger uncharacterized protein XP_059605722.1 3434569 R 5061 CDS An02g14190 4979959 join(3436896..3437119,3437190..3437320,3437373..3438107,3438158..3438819,3438876..3438953) IV 1 NT_166519.1 Similarity: the deduced S. aureofaciens tcr3 amino acid sequence had a high level identity with that of the self-defense gene (tet347) of Streptomyces rimosus, known to mediate oxytetracycline efflux.; Title: similarity to hypothetical self-defense gene tcr3 - Streptomyces aureofaciens; See PMID 8534971; uncharacterized protein 3438953 4979959 An02g14190 Aspergillus niger uncharacterized protein XP_001400550.1 3436896 D 5061 CDS An02g14200 4979960 join(3441379..3441398,3441599..3441718,3441899..3442277,3442334..3442393) IV 1 NT_166519.1 Function: the P. marneffei CflA initiates polarized growth and extension of the germ tube and subsequently maintains polarized growth in the vegetative mycelium.; Remark: heterologous expression of cflA alleles in A. nidulans prevents conidiation.; Similarity: the P. marneffei CflA belongs to the Rho family of GTPases.; Title: strong similarity to CDC42-like protein CflA - Penicillium marneffei; See PMID 11344153; uncharacterized protein 3442393 4979960 An02g14200 Aspergillus niger uncharacterized protein XP_001400551.1 3441379 D 5061 CDS An02g14210 4979961 complement(join(3443437..3444452,3444511..3444637,3444695..3444820)) IV 1 NT_166519.1 Catalytic activity: the E. coli agmanitase converts agmatine and H2O to putrescine and urea.; Function: the predicted E. coli agmanitase protein is involved in the putrescine biosynthetic pathway and thus in the proline and arginine metabolism.; Remark: an alternate name for the agmanitase is agmatine ureohydrolase.; Title: strong similarity to hypothetical agmanitase - Escherichia coli; See PMID 1310091; uncharacterized protein 3444820 4979961 An02g14210 Aspergillus niger uncharacterized protein XP_001400552.1 3443437 R 5061 CDS An02g14220 4979962 join(3445395..3445446,3445656..3445822,3445871..3445978,3446028..3446099,3446149..3446235,3446284..3446550,3446600..3446968,3447018..3447182) IV 1 NT_166519.1 Function: the enzyme catalyzes the condensation of malonyl-ACP with the growing fatty acid chain.; Similarity: the E. coli fabJ gene product belongs to the beta-ketoacyl-ACP-synthase familiy.; Title: strong similarity to 3-oxoacyl-(acyl-carrier-protein) synthase fabJ -Escherichia coli; See PMID 7972002; uncharacterized protein 3447182 4979962 An02g14220 Aspergillus niger uncharacterized protein XP_001400553.1 3445395 D 5061 CDS An02g14230 4979963 join(3447894..3447918,3448041..3448928,3449002..3449420) IV 1 NT_166519.1 Title: similarity to hypothetical protein SPCC126.04c - Schizosaccharomyces pombe; uncharacterized protein 3449420 4979963 An02g14230 Aspergillus niger uncharacterized protein XP_059605723.1 3447894 D 5061 CDS An02g14240 4979964 3450089..3451318 IV 1 NT_166519.1 Catalytic activity: the S. cerevisiae guanyllytransferase converts GTP and (5')PP-pur-mRNA to diphosphate and G(5')PPP-pur-mRNA.; Remark: Can modify also synthetic poly(A) and poly(G) to form the structures M(7)G(5')pppA(N) and M(7)G(5')pppG(N).; Remark: the S. cerevisiae guanyllytransferase is also referred to as mRNA capping enzyme.; Title: strong similarity to mRNA guanylyltransferase - Saccharomyces cerevisiae; See PMID 1315757; uncharacterized protein 3451318 4979964 An02g14240 Aspergillus niger uncharacterized protein XP_001400555.1 3450089 D 5061 CDS An02g14250 84590569 complement(join(3451674..3451782,3451823..3451925,3451956..3452100,3452162..3452254)) IV 1 NT_166519.1 hypothetical protein 3452254 84590569 An02g14250 Aspergillus niger hypothetical protein XP_059605724.1 3451674 R 5061 CDS An02g14260 84590570 complement(join(3453574..3453625,3453672..3453784,3453941..3454099,3454246..3454270,3454452..3454492)) IV 1 NT_166519.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 3454492 84590570 An02g14260 Aspergillus niger uncharacterized protein XP_059605725.1 3453574 R 5061 CDS An02g14270 4979967 complement(join(3455704..3456549,3456633..3456752)) IV 1 NT_166519.1 hypothetical protein 3456752 4979967 An02g14270 Aspergillus niger hypothetical protein XP_001400558.1 3455704 R 5061 CDS An02g14280 4979968 join(3457955..3458094,3458180..3459473,3459548..3460000) IV 1 NT_166519.1 Title: similarity to hypothetical membrane protein YPR157w - Saccharomyces cerevisiae; uncharacterized protein 3460000 4979968 An02g14280 Aspergillus niger uncharacterized protein XP_059605726.1 3457955 D 5061 CDS An02g14290 4979969 complement(join(3460501..3460511,3460556..3460569,3460681..3461465,3461523..3461837,3461890..3462212,3462276..3462514,3462591..3462727)) IV 1 NT_166519.1 Function: the R. toruloides cephalosporin esterase hydrosyses the acetyl estyl bond on the 10-position of the antibiotic cephalosporin C, producingDeacetylcephalosporin and acetate.; Pathway: the cephalosporin cleavage is part of the penicillin and cephalosporin metabolism.; Title: strong similarity to cephalosporin esterase -Rhodosporidium toruloides; See PMID 9406399; uncharacterized protein 3462727 4979969 An02g14290 Aspergillus niger uncharacterized protein XP_059605727.1 3460501 R 5061 CDS An02g14300 4979970 join(3463493..3463681,3463746..3463785,3463857..3463924,3463998..3464371,3464426..3464490,3464550..3464989) IV 1 NT_166519.1 Function: pth11 of M. grisea is involved in host surface recognition.; Similarity: the ORF is about 260 amino acids shorter than pth11 of M. grisea.; Similarity: the ORF is shorter than pth11 of M. grisea (391 compared to 631 amino acids).; Similarity: the ORF shows similarity to the EST seq id no:6959 of patent WO200056762-A2 - Aspergillus oryzae; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; uncharacterized protein 3464989 4979970 An02g14300 Aspergillus niger uncharacterized protein XP_001400561.1 3463493 D 5061 CDS An02g14310 4979971 complement(join(3465938..3466876,3466956..3469376)) IV 1 NT_166519.1 Remark: an alterntative gene name for PHF2 is GRC5.; Title: strong similarity to PHD-finger protein PHF2 - Homo sapiens; uncharacterized protein 3469376 4979971 An02g14310 Aspergillus niger uncharacterized protein XP_001400562.3 3465938 R 5061 CDS An02g14320 84590571 join(3470467..3470646,3470787..3470975) IV 1 NT_166519.1 hypothetical protein 3470975 84590571 An02g14320 Aspergillus niger hypothetical protein XP_059605728.1 3470467 D 5061 CDS An02g14330 4979973 join(3471322..3471353,3471497..3471520,3471657..3471713,3471786..3471913,3471995..3472095) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein HSPC175 - Homo sapiens; uncharacterized protein 3472095 4979973 An02g14330 Aspergillus niger uncharacterized protein XP_001400564.3 3471322 D 5061 CDS An02g14340 4979974 join(3473383..3473401,3473458..3473553,3473610..3473872) IV 1 NT_166519.1 Complex: the U5 snRNP is part of the splicosome.; Remark: SNU13 of S. cerevisiae constitutes the U4/U6. U5 snRNP (small nuclear ribonucleoprotein particle) component.; Remark: SNU13 of S. cerevisiae is also called YEL026w.; Similarity: strong similarity to ribosomal protein L7a superfamily.; Similarity: the ORF shows strong similarity to the A. niger EST no:3887 of patent WO200056762-A2.; Title: strong similarity to RNA-binding protein Snu13 - Saccharomyces cerevisiae; See PMID 11720284; uncharacterized protein 3473872 4979974 An02g14340 Aspergillus niger uncharacterized protein XP_001400565.1 3473383 D 5061 CDS An02g14350 4979975 join(3474760..3474826,3474926..3475230,3475290..3475931) IV 1 NT_166519.1 Similarity: the ORF shows strong similarity to expressed sequence tag an_2353 from Aspergillus niger.; Title: strong similarity to hypothetical protein B14D6.530 - Neurospora crassa; uncharacterized protein 3475931 4979975 An02g14350 Aspergillus niger uncharacterized protein XP_059605729.1 3474760 D 5061 CDS An02g14360 4979976 join(3476360..3476692,3476762..3477250,3477304..3477475,3477556..3478158,3478223..3478326,3478510..3478530) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein SPBC29A3.06 - Schizosaccharomyces pombe; uncharacterized protein 3478530 4979976 An02g14360 Aspergillus niger uncharacterized protein XP_059605730.1 3476360 D 5061 CDS An02g14370 84590572 complement(join(3478998..3479060,3479162..3479521)) IV 1 NT_166519.1 hypothetical protein 3479521 84590572 An02g14370 Aspergillus niger hypothetical protein XP_059605731.1 3478998 R 5061 CDS An02g14380 4979978 complement(join(3480258..3481133,3481198..3481605,3481695..3481720,3481803..3481925,3482016..3482055)) IV 1 NT_166519.1 Catalytic activity: ATP + D-hexose <=> ADP + D-hexose 6-phosphate.; Function: A. niger hxk is responsible for phosphorylation of glucose and fructose. D-Glucose, the glucose analogue 2-deoxy-D-glucose, D-fructose, D-mannose and D-glucosamine are phosphorylated by hexokinase, whereas the hexoses D-galactose, L-sorbose, methyl alpha-D-glucoside and the pentoses L-arabinose and D-xylose are not.; Gene-ID: hxk; Mapping: hxk from A. niger is mapped to chromosome VI; see EMBL AJ009973.; hexokinase hxk-Aspergillus niger 3482055 hxk 4979978 hxk Aspergillus niger hexokinase hxk-Aspergillus niger XP_001400569.1 3480258 R 5061 CDS An02g14390 4979979 complement(join(3482846..3483859,3483972..3484094)) IV 1 NT_166519.1 Complex: Sir2p is one of four Silent Information Regulator genes in yeast. Sir2p (but not the other Sir proteins) is a component of the nucleolar complex called RENT, a regulator of nucleolar silencing and telophase exit.; Function: the S. cerevisiae homolog Sir2p is a NAD-dependent histone deacetylase and participates in maintenance of silencing of HMR, HML and telomeres. unlike repressors that act by binding to promoters, the Sir proteins help repress transcription by creating a silent chromatin stucture in a gene- and promoter-independent manner. the Sir proteins do not bind DNA directly, but rather seem to act via histones and other DNA binding proteins.; Title: strong similarity to regulator protein Sir2 -Saccharomyces cerevisiae; nucleus; uncharacterized protein 3484094 4979979 An02g14390 Aspergillus niger uncharacterized protein XP_059605732.1 3482846 R 5061 CDS An02g14400 4979980 join(3484671..3485861,3485912..3487016,3487261..3487268) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein SPCC338.13 - Schizosaccharomyces pombe; uncharacterized protein 3487268 4979980 An02g14400 Aspergillus niger uncharacterized protein XP_001400571.3 3484671 D 5061 CDS An02g14410 4979981 complement(join(3488254..3488897,3488954..3489545,3489604..3489935,3489995..3490103)) IV 1 NT_166519.1 Function: the S. cerevisiae homolog Mep3p is an ammonia permease of high capacity and low affinity.; Repression: the S. cerevisiae MEP genes are subject to nitrogen control, in the presence of a good nitrogen source, all three MEP genes are repressed.; Similarity: shows sequence similarity to S. cerevisiae Mep1p and Mep2p.; Title: strong similarity to ammonium transport protein Mep3 - Saccharomyces cerevisiae; uncharacterized protein 3490103 4979981 An02g14410 Aspergillus niger uncharacterized protein XP_001400572.1 3488254 R 5061 CDS An02g14420 84590573 join(3490176..3490222,3490265..3490405,3490597..3490849,3491204..3491337,3491417..3491598,3491725..3491831,3491952..3492098,3492183..3492244,3492340..3492418) IV 1 NT_166519.1 hypothetical protein 3492418 84590573 An02g14420 Aspergillus niger hypothetical protein XP_059605733.1 3490176 D 5061 CDS An02g14430 84590574 join(3492912..3492990,3493033..3493126,3493209..3493444,3494068..3494345,3494439..3494529,3494609..3494716,3494801..3494904) IV 1 NT_166519.1 hypothetical protein 3494904 84590574 An02g14430 Aspergillus niger hypothetical protein XP_059605734.1 3492912 D 5061 CDS An02g14450 4979985 complement(join(3495485..3495505,3495639..3496108,3496161..3498648,3498756..3498863)) IV 1 NT_166519.1 Function: pmrA is a P-type Ca(2+)-ATPases with a high degree of sequence similarity to the Pmr1 proteins from yeasts and mammalians and is involved in in Ca(2+) and Mn(2+) homeostasis in A. niger.; Gene-ID: pmrA; secretory pathway Ca2+-ATPase pmrA-Aspergillus niger 3498863 pmrA 4979985 pmrA Aspergillus niger secretory pathway Ca2+-ATPase pmrA-Aspergillus niger XP_059605735.1 3495485 R 5061 CDS An02g14460 4979986 join(3500244..3500507,3500580..3502085) IV 1 NT_166519.1 Function: the S. pombe homolog rad21 is a gene essential in mitotic growth that is involved in DNA double-strand-break repair. Further functions of rad21 are related to chromosome segregation and microtubule function.; Title: strong similarity to double-strand-break repair protein rad21p - Schizosaccharomyces pombe; nucleus; uncharacterized protein 3502085 4979986 An02g14460 Aspergillus niger uncharacterized protein XP_001400576.1 3500244 D 5061 CDS An02g14470 4979987 join(3503440..3503870,3503926..3504035,3504095..3504129,3504190..3504434,3504489..3504521,3504576..3504662,3504713..3505122,3505183..3505294,3505369..3505552) IV 1 NT_166519.1 Remark: MDR1 of C. albicans is also called BMR.; Similarity: the ORF shows similarity to multiple drug resistance proteins from several species.; Title: strong similarity to benomyl/methotrexate resistance protein MDR1 - Candida albicans; plasma membrane; See PMID 9745021; uncharacterized protein 3505552 4979987 An02g14470 Aspergillus niger uncharacterized protein XP_001400577.3 3503440 D 5061 CDS An02g14480 84590575 complement(join(3505740..3506032,3506272..3506377,3506479..3506487,3507039..3507142,3507218..3507315,3507445..3507519,3507600..3507681,3507831..3508026,3508104..3508271)) IV 1 NT_166519.1 hypothetical protein 3508271 84590575 An02g14480 Aspergillus niger hypothetical protein XP_059605736.1 3505740 R 5061 CDS An02g14490 4979989 join(3508883..3509126,3509276..3511074,3511128..3511145) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein B24B19.80 - Neurospora crassa; uncharacterized protein 3511145 4979989 An02g14490 Aspergillus niger uncharacterized protein XP_001400579.1 3508883 D 5061 CDS An02g14500 4979990 complement(3511489..3512121) IV 1 NT_166519.1 Similarity: the ORF shows strong similarity to the A. niger EST an_3015.; Title: similarity to hypothetical protein encoded by An11g03520 - Aspergillus niger; uncharacterized protein 3512121 4979990 An02g14500 Aspergillus niger uncharacterized protein XP_001400580.1 3511489 R 5061 CDS An02g14520 4979991 join(3513563..3513631,3513727..3513868,3513938..3514460,3514517..3514908,3514962..3515315,3515366..3515446,3515496..3515554) IV 1 NT_166519.1 Catalytic activity: ATP + xanthosine 5'-phosphate + L-glutamine + H(2)O <=> AMP + diphosphate + GMP + L-glutamate.; Function: the S. cerevisiae homolog Gua1p is a GMP synthetase which catalyzes the amination of xanthine monophosphate to guanine monophosphate in the guanine branch of the purine biosynthesis pathway.; Pathway: GMP biosynthesis pathway.; Title: strong similarity to GMP synthase (glutamine-hydrolyzing) Gua1 - Saccharomyces cerevisiae; uncharacterized protein 3515554 4979991 An02g14520 Aspergillus niger uncharacterized protein XP_001400581.1 3513563 D 5061 CDS An02g14530 4979992 join(3515887..3516003,3516066..3516248,3516331..3516609,3516688..3516753) IV 1 NT_166519.1 Title: strong similarity to electron transfer protein ETRN-4 from patent WO200105969-A2 - Homo sapiens; uncharacterized protein 3516753 4979992 An02g14530 Aspergillus niger uncharacterized protein XP_001400582.3 3515887 D 5061 CDS An02g14540 4979993 join(3517117..3517366,3517566..3518204,3518274..3518342,3518430..3518785) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein PA2682 - Pseudomonas aeruginosa; uncharacterized protein 3518785 4979993 An02g14540 Aspergillus niger uncharacterized protein XP_059605737.1 3517117 D 5061 CDS An02g14550 4979994 complement(join(3518894..3520166,3520225..3520525,3520578..3520808,3520855..3520996,3521043..3521251,3521305..3521494)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein SPBC1861.05 - Schizosaccharomyces pombe; uncharacterized protein 3521494 4979994 An02g14550 Aspergillus niger uncharacterized protein XP_001400584.1 3518894 R 5061 CDS An02g14560 4979995 join(3521823..3522175,3522297..3523329,3523394..3523519) IV 1 NT_166519.1 Complex: ostA is the alpha-chain of the A. niger oligosaccharyltransferase.; Function: the oligosaccharyltransferase complex catalyzes the asparagine-linked glycosylation of proteins in the lumen of the endoplasmic reticulum.; Gene-ID: ostA; oligosaccharyltransferase alpha subunit ostA-Aspergillus niger 3523519 ostA 4979995 ostA Aspergillus niger oligosaccharyltransferase alpha subunit ostA-Aspergillus niger XP_001400585.1 3521823 D 5061 CDS An02g14570 84590576 complement(join(3523694..3523736,3523790..3523895,3524117..3524209,3524290..3524539,3524618..3524752)) IV 1 NT_166519.1 hypothetical protein 3524752 84590576 An02g14570 Aspergillus niger hypothetical protein XP_059605738.1 3523694 R 5061 CDS An02g14580 84590577 complement(join(3525653..3525715,3525794..3526006,3526113..3526151,3526309..3526358,3526445..3526489,3526767..3526979,3527102..3527180,3527326..3527474,3527533..3527647)) IV 1 NT_166519.1 hypothetical protein 3527647 84590577 An02g14580 Aspergillus niger hypothetical protein XP_059605739.1 3525653 R 5061 CDS An02g14590 4979998 join(3527883..3528201,3528275..3531108,3531162..3531262,3531322..3531367) IV 1 NT_166519.1 Catalytic activity: L-glutamate + H(2)O + NAD(+) <=> 2-oxoglutarate + NH(3) + NADH.; Complex: S. cerevisiae Gdh2p forms a homotetramer.; Function: the S. cerevisiae homolog Gdh2p is a NAD-dependent glutamate dehydrogenase.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to glutamate dehydrogenase Gdh2 - Saccharomyces cerevisiae; uncharacterized protein 3531367 4979998 An02g14590 Aspergillus niger uncharacterized protein XP_001400588.1 3527883 D 5061 CDS An02g14600 4979999 complement(join(3531889..3532057,3532122..3534331)) IV 1 NT_166519.1 Function: the N. crassa homolog CIA84 is a nuclear encoded, mitochondria targeted chaperone involved in the in the assembly of mitochondrial NADH:ubiquinone oxidoreductase (complex I).; Title: strong similarity to NADH:ubiquinone reductase intermediate-associated protein CIA84 -Neurospora crassa; See PMID 9769214; uncharacterized protein 3534331 4979999 An02g14600 Aspergillus niger uncharacterized protein XP_001400589.1 3531889 R 5061 CDS An02g14610 4980000 join(3534727..3534871,3534917..3535230,3535321..3535527) IV 1 NT_166519.1 Function: ribosomal protein S18 is involved in the binding of fMet-tRNA, and hence the initiation of translation.; Similarity: shows similarity to the ribosomal subunit S18 of several species.; Title: similarity to ribosomal protein of the small subunit S18 rpsR - Escherichia coli; See PMID 6210737; See PMID 10094780; mitochondrial 37S ribosomal protein bS18m 3535527 4980000 An02g14610 Aspergillus niger mitochondrial 37S ribosomal protein bS18m XP_059605740.1 3534727 D 5061 CDS An02g14620 4980001 join(3536051..3536066,3536127..3536215,3536294..3538027) IV 1 NT_166519.1 Complex: the S. cerevisiae homolog Aip1p interacts with the ubiquitous actin depolymerizing factor cofilin.; Function: S. cerevisiae Aip1p is a cofilin-associated protein that enhances the filament disassembly activity of cofilin and restricts cofilin localization to cortical actin patches.; Title: strong similarity to actin interacting protein Aip1 - Saccharomyces cerevisiae; cytoskeleton; uncharacterized protein 3538027 4980001 An02g14620 Aspergillus niger uncharacterized protein XP_001400591.1 3536051 D 5061 CDS An02g14630 4980002 join(3538402..3538461,3538669..3539181,3539347..3539967,3540024..3540285,3540430..3541503,3541556..3541717,3541787..3541890) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein CAD37054.1 - Neurospora crassa; uncharacterized protein 3541890 4980002 An02g14630 Aspergillus niger uncharacterized protein XP_059605741.1 3538402 D 5061 CDS An02g14640 4980003 join(3542884..3543103,3543173..3543534,3543615..3543723,3543800..3544458) IV 1 NT_166519.1 Similarity: the ORF shows strong similarity to expressed sequence tag seq id no:5842 of patent WO200056762-A2 from Aspergillus oryzae.; Title: strong similarity to transcriptional coactivator HFI1 related protein CAD71048.1 - Neurospora crassa; uncharacterized protein 3544458 4980003 An02g14640 Aspergillus niger uncharacterized protein XP_059605742.1 3542884 D 5061 CDS An02g14650 4980004 complement(join(3545692..3545835,3545905..3548197,3548318..3548700)) IV 1 NT_166519.1 Function: the S. pombe homolog prp1 is involved in in pre-mRNA splicing, cell cycle progression and/or poly(A)+ RNA nuclear export.; Title: strong similarity to hypothetical pre-mRNA splicing factor prp1p - Schizosaccharomyces pombe; uncharacterized protein 3548700 4980004 An02g14650 Aspergillus niger uncharacterized protein XP_001400594.1 3545692 R 5061 CDS An02g14660 4980005 join(3549023..3549208,3549283..3549504,3549567..3549968,3550173..3550322) IV 1 NT_166519.1 Function: the S. cerevisiae homolog Dim1p is an essential protein responsible for m6[2]Am6[2]A dimethylation in 3'-terminal loop of 18S rRNA.; Title: strong similarity to rRNA (adenine-N6,N6-)-dimethyltransferase Dim1 - Saccharomyces cerevisiae; uncharacterized protein 3550322 4980005 An02g14660 Aspergillus niger uncharacterized protein XP_059605743.1 3549023 D 5061 CDS An02g14670 4980006 complement(join(3550417..3550578,3550634..3550726,3550791..3551674,3551721..3552208,3552294..3552380,3552518..3552601,3552690..3552748)) IV 1 NT_166519.1 Similarity: the N. crassa homolog 2E4. 120 shows similarity to GYP1, the GTPase activating protein for Ypt1p and Sec4p.; Title: strong similarity to hypothetical protein 2E4.120 - Neurospora crassa; uncharacterized protein 3552748 4980006 An02g14670 Aspergillus niger uncharacterized protein XP_059605744.1 3550417 R 5061 CDS An02g14680 84590578 join(3553799..3553842,3553906..3554188) IV 1 NT_166519.1 Remark: a splice site was detected upstream of the START codon.; hypothetical protein 3554188 84590578 An02g14680 Aspergillus niger hypothetical protein XP_059605745.1 3553799 D 5061 CDS An02g14690 4980008 join(3555574..3555610,3555679..3555842,3555917..3556994,3557047..3557183) IV 1 NT_166519.1 Complex: S. cerevisiae Hrp1p is one of five subunits of cleavage factor I (CF I), which is required for cleavage activity in vitro when mixed with CF II and for specific polyadenylation when mixed with polyadenylation factor I.; Function: the S. cerevisiae homolog Hrp1p is involved in cleavage and polyadenylation of mRNA 3' ends.; Title: strong similarity to heterogeneous nuclear ribonucleoprotein Hrp1 - Saccharomyces cerevisiae; nucleus; uncharacterized protein 3557183 4980008 An02g14690 Aspergillus niger uncharacterized protein XP_059605746.1 3555574 D 5061 CDS An02g14700 84590579 complement(join(3557473..3557574,3557639..3557797)) IV 1 NT_166519.1 hypothetical protein 3557797 84590579 An02g14700 Aspergillus niger hypothetical protein XP_059605747.1 3557473 R 5061 CDS An02g14710 4980010 complement(3558265..3560448) IV 1 NT_166519.1 Function: the N. crassa SPRAY protein is supposed to be located in an organellar membrane, regulating the distribution of Ca(2+) via calcineurin.; Phenotype: the N. crassa spray mutant is sensitive to calcineurin inhibitors.; Remark: between the contig-sequence positions 193548 - 193933 one or more introns may be missing (contig DNA sequence deduced from cDNA).; Title: strong similarity to hypothetical calcium-related spray protein - Neurospora crassa; See PMID 11343401; uncharacterized protein 3560448 4980010 An02g14710 Aspergillus niger uncharacterized protein XP_001400600.1 3558265 R 5061 CDS An02g14720 4980011 complement(join(3563268..3563914,3563978..3564511,3564604..3564901)) IV 1 NT_166519.1 Function: the predicted A. vitis protein ttuB codes for a protein with homology to transporter proteins and is required for entry of tartrate into bacteria.; Title: strong similarity to hypothetical tartrate transport protein ttuB - Agrobacterium vitis; See PMID 7592429; uncharacterized protein 3564901 4980011 An02g14720 Aspergillus niger uncharacterized protein XP_001400601.1 3563268 R 5061 CDS An02g14730 4980012 complement(join(3565162..3566059,3566139..3566593)) IV 1 NT_166519.1 Remark: the expression of the M. musculus IRG1 is altered upon the activation of macrophages by bacterial LPS.; Title: similarity to immune response protein IRG1 -Mus musculus; See PMID 7721348; uncharacterized protein 3566593 4980012 An02g14730 Aspergillus niger uncharacterized protein XP_001400602.1 3565162 R 5061 CDS An02g14740 4980013 complement(join(3567011..3567261,3567360..3568203)) IV 1 NT_166519.1 hypothetical protein 3568203 4980013 An02g14740 Aspergillus niger hypothetical protein XP_059605748.1 3567011 R 5061 CDS An02g14750 4980014 join(3568653..3568695,3568787..3569285,3569359..3570235) IV 1 NT_166519.1 Remark: actin-related proteins (Arps), which are divergent, but apparently homologues to actin, are categorized into 10 classes.; Similarity: the predicted A. niger protein contains three actin like domains (aa 13-101, 141-221, 323-472) and is therefore showing similarity to a broad range of actin-like proteins.; Title: strong similarity to actin-related protein -Homo sapiens; See PMID 10380635; uncharacterized protein 3570235 4980014 An02g14750 Aspergillus niger uncharacterized protein XP_001400604.1 3568653 D 5061 CDS An02g14760 4980015 complement(join(3570965..3572032,3572092..3572677,3572793..3573028)) IV 1 NT_166519.1 hypothetical protein 3573028 4980015 An02g14760 Aspergillus niger hypothetical protein XP_059605749.1 3570965 R 5061 CDS An02g14770 4980016 complement(join(3574563..3575230,3575366..3576514,3576629..3576653)) IV 1 NT_166519.1 Title: strong similarity to hypothetical protein EAA62014.1 - Aspergillus nidulans; uncharacterized protein 3576653 4980016 An02g14770 Aspergillus niger uncharacterized protein XP_059605750.1 3574563 R 5061 CDS An02g14780 84590580 complement(join(3577128..3577236,3577293..3577334,3577421..3577452)) IV 1 NT_166519.1 hypothetical protein 3577452 84590580 An02g14780 Aspergillus niger hypothetical protein XP_059605751.1 3577128 R 5061 CDS An02g14790 4980018 join(3577513..3577874,3577948..3578407,3578472..3578768) IV 1 NT_166519.1 Function: UNG1 encodes the repair enzyme uracil-DNA-glycosylase.; Phenotype: the UNG1 null mutant is viable.; Similarity: the carboxyl-terminal two-thirds of UNG1 is highly homologous to the entire Escherichia coli enzyme (50% amino acid identity).; Title: strong similarity to uracil-DNA glycosylase Ung1 - Saccharomyces cerevisiae; nucleus; See PMID 2644266; uncharacterized protein 3578768 4980018 An02g14790 Aspergillus niger uncharacterized protein XP_001400608.1 3577513 D 5061 CDS An02g14800 4980019 complement(join(3579372..3579738,3579806..3580245,3580345..3580723,3580822..3581183)) IV 1 NT_166519.1 Function: pdiA from A. niger catalyzes the refolding of denatured and reduced RNase A.; Function: pdiA from A. niger complements PDI function in a S. cerevisiae pdi1 deletion mutant.; Function: pdiA from A. niger encodes a putative protein disulphide isomerase.; Gene-ID: pdiA;pdi1; Remark: a synonym for pdiA from A. niger is pdi1.; Remark: the transcription of pdiA from A. niger is induced 3-4-fold after treatment with tunicamycin, an inhibitor of N-linked glycosylation.; See PMID 9021130; See PMID 10653750; protein disulfide isomerase A pdiA-Aspergillus niger 3581183 pdiA 4980019 pdiA Aspergillus niger protein disulfide isomerase A pdiA-Aspergillus niger XP_001400609.1 3579372 R 5061 CDS An02g14810 4980020 complement(join(3582315..3583387,3583499..3583999,3584059..3584218)) IV 1 NT_166519.1 Function: Aut4 from S. cerevisiae is essential for the disintegration of autophagic vesicles, inside the vacuole of cells.; Localization: a biologically active fusion protein of Aut4 from S. cerevisiae and the green fluorescent protein is visualized at the vacuolar membrane and in punctate structures attached to the vacuole.; Remark: Aut4 from S. cerevisiae is a putative integral membrane protein with limited homologies to permeases.; Title: strong similarity to protein involved in autophagic vesicle breakdown Aut4 - Saccharomyces cerevisiae; See PMID 1105808; uncharacterized protein 3584218 4980020 An02g14810 Aspergillus niger uncharacterized protein XP_059605752.1 3582315 R 5061 CDS An02g14820 4980021 join(3585687..3586370,3586436..3589081) IV 1 NT_166519.1 Complex: RGR1 interacts with SIN4 to organize chromatin structure and thus regulate transcription.; Function: RGR1 is required to repress the expression of glucose-regulated genes.; Title: strong similarity to regulator protein Rgr1 -Saccharomyces cerevisiae; nucleus; See PMID 7635307; See PMID 2196447; uncharacterized protein 3589081 4980021 An02g14820 Aspergillus niger uncharacterized protein XP_001400611.3 3585687 D 5061 CDS An02g14830 4980022 complement(3589536..3591782) IV 1 NT_166519.1 Catalytic activity: DPB2 catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.; Function: DPB2, the gene encoding DNA polymerase II subunit B, is required for chromosome replication in S. cerevisiae.; Phenotype: disruption of DPB2 is lethal.; Title: strong similarity to DNA polymerase II subunit-B Dpb2 - Saccharomyces cerevisiae; nucleus; See PMID 2052544; uncharacterized protein 3591782 4980022 An02g14830 Aspergillus niger uncharacterized protein XP_001400612.1 3589536 R 5061 CDS An02g14840 4980023 join(3592381..3593430,3593519..3593806) IV 1 NT_166519.1 Title: similarity to protein sequence #9319 from patent WO200175067-A2 - Homo sapiens; uncharacterized protein 3593806 4980023 An02g14840 Aspergillus niger uncharacterized protein XP_001400613.1 3592381 D 5061 CDS An02g14850 4980024 complement(3594266..3594964) IV 1 NT_166519.1 Title: similarity to barley containing SNP protein fragment SEQ ID NO:660 from patent WO2003057877-A1 -Hordeum vulgare; uncharacterized protein 3594964 4980024 An02g14850 Aspergillus niger uncharacterized protein XP_001400614.1 3594266 R 5061 CDS An02g14860 4980025 complement(join(3595381..3595597,3595685..3596080,3596160..3596263)) IV 1 NT_166519.1 Function: Antizyme protein binds to, and inhibits,ornithine decarboxylase ODC, a key enzyme in polyamine biosynthesis.; Remark: The matching EST is from Aspergillus niger deviates in several positions from the sequence of the genomic DNA.; Title: strong similarity to ornithine decarboxylase antizyme - Aspergillus nidulans; See PMID 10954585; uncharacterized protein 3596263 4980025 An02g14860 Aspergillus niger uncharacterized protein XP_001400615.3 3595381 R 5061 CDS An02g14870 4980026 complement(join(3597439..3598858,3598932..3599220,3599395..3599566)) IV 1 NT_166519.1 Title: strong similarity to hypothetical conserved zinc-finger protein - Schizosaccharomyces pombe; uncharacterized protein 3599566 4980026 An02g14870 Aspergillus niger uncharacterized protein XP_059605753.1 3597439 R 5061 CDS An02g14880 4980027 join(3601298..3601319,3601384..3601732,3601790..3602151,3602218..3602350,3602406..3602556) IV 1 NT_166519.1 Catalytic activity: dCMP + H2O = dUMP + NH3; Pathway: DCD1 plays a role in dTTP biosynthesis.; Phenotype: DCD1 mutant is viable, resistant to 5-fluoro-2'-deoxycytidylate.; Title: strong similarity to dCMP deaminase Dcd1 -Saccharomyces cerevisiae; See PMID 6373725; See PMID 3023902; uncharacterized protein 3602556 4980027 An02g14880 Aspergillus niger uncharacterized protein XP_059605754.1 3601298 D 5061 CDS An02g14890 4980028 join(3603807..3603929,3603983..3605431,3605504..3605593) IV 1 NT_166519.1 Function: HIS7 encodes a bifunctional glutamine amidotransferase: cyclase from S. cerevisiae.; Induction: HIS7 gene expression is regulated by the general control system of amino acid biosynthesis.; Pathway: HIS7 represents the first isolated eukaryotic gene encoding the enzymatic activities which catalyze the fifth and sixth step in histidine biosynthesis.; Title: strong similarity to amidotransferase/cyclase His7 - Saccharomyces cerevisiae; See PMID 8366040; uncharacterized protein 3605593 4980028 An02g14890 Aspergillus niger uncharacterized protein XP_001400618.1 3603807 D 5061 CDS An02g14900 4980029 join(3606707..3606897,3606969..3607077,3607133..>3607648) IV 1 NT_166519.1 Remark: C-terminally truncated due to contig border.; Remark: the C-terminal part of the gene is located on contig An02c0480.; Title: similarity to human peptidase HPEP-14 from patent WO200042201-A2 - Homo sapiens [truncated orf]; uncharacterized protein 3607648 4980029 An02g14900 Aspergillus niger uncharacterized protein XP_001400619.3 3606707 D 5061 CDS An02g14910 84590581 join(<3607751..3608047,3608098..3608460,3608586..3608660) IV 1 NT_166519.1 Remark: N-terminally truncated due to contig border.; Remark: the N-terminal part of the gene is located on contig An02c0460.; Title: similarity to human peptidase HPEP-14 from patent WO200042201-A2 - Homo sapiens [truncated orf]; uncharacterized protein 3608660 84590581 An02g14910 Aspergillus niger uncharacterized protein XP_059600144.1 3607751 D 5061 CDS An02g14920 4980031 complement(join(3608947..3609030,3609102..3609150,3609214..3609512,3609572..3609598,3609669..3609719,3609775..3609957)) IV 1 NT_166519.1 Remark: ftsJ has been renamed rrmJ.; Remark: the methylation reaction catalyzed by ftsJ requires S-adenosylmethionine as donor of methyl groups.; Remark: the natural substrate for ftsJ are ribosomes or a pre-ribosomal ribonucleoprotein particle.; Title: strong similarity to 23S rRNA methyltransferase ftsJ - Escherichia coli; See PMID 10748051; uncharacterized protein 3609957 4980031 An02g14920 Aspergillus niger uncharacterized protein XP_059600145.1 3608947 R 5061 CDS An02g14930 4980032 join(3610850..3611194,3611258..3611355,3611411..3611766,3611844..3611951,3611984..3612037,3612187..3612233) IV 1 NT_166519.1 Complex: OST3 corresponds to the 34-kD gamma-subunit of the yeast oligosaccharyltransferase.; Phenotype: expression of OST3 is not essential for viability, however its loss is accompanied by significant underglycosylation of soluble and membrane-bound glycoproteins in vivo.; Remark: within the lumen of the rough endoplasmic reticulum, oligosaccharyltransferase catalyzes the en bloc transfer of a high mannose oligosaccharide moiety from the lipid-linked oligosaccharide donor to asparagine acceptor sites in nascent polypeptides.; Title: strong similarity to dolichyl-diphosphooligosaccharide-protein glycotransferase gamma chain Ost3 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 7622558; uncharacterized protein 3612233 4980032 An02g14930 Aspergillus niger uncharacterized protein XP_059600146.1 3610850 D 5061 CDS An02g14940 4980033 join(3613220..3613983,3614043..3614892) IV 1 NT_166519.1 Title: strong similarity to human transmembrane protein HTMPN-23 from patent WO9961471-A2 - Homo sapiens; uncharacterized protein 3614892 4980033 An02g14940 Aspergillus niger uncharacterized protein XP_001400623.3 3613220 D 5061 CDS An02g14950 4980034 complement(join(3615045..3615201,3615263..3615334,3615391..3616649)) IV 1 NT_166519.1 Function: CA3 is required for efficient pre-rRNA processing predominantly at site A3.; Localization: CA3 is localized predominantly in the nucleolus.; Phenotype: genetic depletion of CA3 results in a deficiency of 60S ribosomal subunits and a delayed synthesis of the mature 25S rRNA.; Remark: Dbp3p and CA3 are synonymous.; Remark: in S. cerevisiae, ribosomal biogenesis takes place primarily in the nucleolus, in which a single 35S precursor rRNA (pre-rRNA) is first transcribed and sequentially processed into 25S, 5. 8S, and 18S mature rRNAs, leading to the formation of the 40S and 60S ribosomal subunits.; Title: strong similarity to ATP-dependent RNA helicase Ca3 - Saccharomyces cerevisiae; nucleus; See PMID 9032262; uncharacterized protein 3616649 4980034 An02g14950 Aspergillus niger uncharacterized protein XP_001400624.1 3615045 R 5061 CDS An02g14960 84590582 complement(join(3616924..3616980,3617012..3617215)) IV 1 NT_166519.1 Remark: blastP similarities are solely due to a 60 bp T repeat.; hypothetical protein 3617215 84590582 An02g14960 Aspergillus niger hypothetical protein XP_059600147.1 3616924 R 5061 CDS An02g14970 4980036 complement(join(3617539..3618165,3618228..3618319,3618373..3618639,3618690..3618714)) IV 1 NT_166519.1 Function: mycocerosic acid synthase (MAS) is a multifunctional protein which catalyzes elongation of n-fatty acyl-CoA with methylmalonyl-CoA as the elongating agent.; Remark: mycocerosyl lipids are found uniquely in the cell walls of pathogenic mycobacteria.; Similarity: MAS is the first case of an elongating multifunctional enzyme composed of two identical subunits that resemble the vertebrate fatty acid synthase in size,subunit structure, and linear organization of functional domains.; Title: similarity to mycocerosate synthase MAS -Mycobacterium tuberculosis; See PMID 1527058; uncharacterized protein 3618714 4980036 An02g14970 Aspergillus niger uncharacterized protein XP_001400626.3 3617539 R 5061 CDS An02g14980 4980037 complement(join(3620128..3620221,3620278..3621179,3621234..3621771,3621826..3621916,3621978..3622129,3622179..3622222)) IV 1 NT_166519.1 Catalytic activity: the SpSSB complex is active in single-stranded DNA binding and the T antigen-dependent unwinding of SV40 ori DNA.; Complex: ssb1(+) is a constituent of the heterotrimeric single-stranded DNA-binding protein complex SpSSB.; Title: strong similarity to single-stranded DNA-binding protein 68k chain ssb1p - Schizosaccharomyces pombe; See PMID 8702843; uncharacterized protein 3622222 4980037 An02g14980 Aspergillus niger uncharacterized protein XP_001400627.1 3620128 R 5061 CDS An02g14990 4980038 join(3622805..3622835,3622906..3622973,3623024..3623164,3623235..3623508,3623568..3625248,3625295..3625439) IV 1 NT_166519.1 Catalytic activity: ubiquitin C-terminal thiolester + H(2)O = ubiquitin + a thiol.; Function: UBP1 cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers.; Remark: a splice site was detected upstream of the START codon.; Similarity: UBP1 belongs to family 2 of ubiquitin carboxyl-terminal hydrolases.; Title: strong similarity to ubiquitin carboxyl-terminal hydrolase UBP1 - Homo sapiens; See PMID 7851534; uncharacterized protein 3625439 4980038 An02g14990 Aspergillus niger uncharacterized protein XP_003188599.1 3622805 D 5061 CDS An02g15000 84590583 join(3625708..3625737,3625775..3625850,3625898..3625979,3626057..>3626085) IV 1 NT_166519.1 Remark: C-terminally truncated due to contig border.; hypothetical protein [truncated ORF] 3626085 84590583 An02g15000 Aspergillus niger hypothetical protein [truncated ORF] XP_059600148.1 3625708 D 5061 CDS An07g00010 4981286 join(273..419,484..819) IV 1 NT_166523.1 Title: similarity to hypothetical protein encoded by An07g00070 - Aspergillus niger; uncharacterized protein 819 4981286 An07g00010 Aspergillus niger uncharacterized protein XP_001391094.1 273 D 5061 CDS An07g00020 4981303 1336..2682 IV 1 NT_166523.1 Title: strong similarity to hypothetical protein Z -Streptomyces hygroscopicus; uncharacterized protein 2682 4981303 An07g00020 Aspergillus niger uncharacterized protein XP_001391095.1 1336 D 5061 CDS An07g00030 4981302 complement(join(3260..3604,3677..4011,4078..4279,4342..4398)) IV 1 NT_166523.1 Remark: the ORF shows also strong similarity to proteins with (putative) other functions, such as oxidoreductases and aldo-keto-reductases.; Remark: the potassium channel beta subunit of B. taurus belongs to the fission yeast pyridoxine 4-dehydrogenase superfamily.; Remark: the potassium channel beta subunit of B. taurus shows alpha-dendrotoxin-sensitivity.; Title: strong similarity to oligosaccharyl transferase subunit - Bos taurus; See PMID 8127858; See PMID 8807399; uncharacterized protein 4398 4981302 An07g00030 Aspergillus niger uncharacterized protein XP_001391096.3 3260 R 5061 CDS An07g00040 4981288 join(4959..5012,5078..5290,5429..6000,6138..6921) IV 1 NT_166523.1 Catalytic activity: fcs of Amycolatopsis sp. facilitates the ATP-dependent conversion of ferulic acid to feruloyl-Coenzyme A.; Pathway: the fcs protein of Amycolatopsis sp. participates in the bioconversion of ferulic acid to vanillin.; Remark: ferulic acid is a phenolic compound.; Similarity: the ORF shows similarity to several acid--CoA ligases from different species.; Title: strong similarity to feruloyl-CoA synthase -Amycolatopsis sp.; See PMID 11152072; uncharacterized protein 6921 4981288 An07g00040 Aspergillus niger uncharacterized protein XP_059600820.1 4959 D 5061 CDS An07g00050 4981299 complement(7962..9254) IV 1 NT_166523.1 Similarity: the ORF shows local similarity to ACEII of H. jecorina concerning the zinc-finger region necessary for DNA-binding.; Title: similarity to hypothetical transcription factor ACEII - Hypocrea jecorina; uncharacterized protein 9254 4981299 An07g00050 Aspergillus niger uncharacterized protein XP_001391098.1 7962 R 5061 CDS An07g00060 4981292 join(10275..10510,10594..12088) IV 1 NT_166523.1 Function: the bmr3 transporter of B. subtilis functions as a multidrug transporter: it mediates resistance to puromycin, tosufloxacin, and norfloxacin.; Induction: expression of bmr3 is dependent on the growth phase of B. subtilis.; Title: strong similarity to multidrug transporter bmr3 - Bacillus subtilis; See PMID 9023234; uncharacterized protein 12088 4981292 An07g00060 Aspergillus niger uncharacterized protein XP_001391099.1 10275 D 5061 CDS An07g00070 4981279 complement(join(12748..13104,13170..13328)) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein encoded by An07g00010 - Aspergillus niger; uncharacterized protein 13328 4981279 An07g00070 Aspergillus niger uncharacterized protein XP_001391100.1 12748 R 5061 CDS An07g00080 4981297 join(13864..13929,14017..15123,15233..15562) IV 1 NT_166523.1 Pathway: the avnA protein of A. parasiticus is involved in the conversion of averantin to averufin in the aflatoxin biosynthetic pathway.; Phenotype: disruption of the avnA gene of A. parasiticus halts the aflatoxin production.; Remark: Aflatoxins are synthesized by condensation of acetate units.; Remark: Aflatoxins are toxic and carcinogenic secondary metabolites produced by the fungi Aspergillus flavus and A. parasiticus.; Remark: avnA of A. parasiticus encodes a cytochrome P-450-type monooxygenase belonging to a new P-450 gene family named CYP60A1.; Title: strong similarity to cytochrome P450 monooxygenase avnA - Aspergillus parasiticus; See PMID 7793957; See PMID 9097431; uncharacterized protein 15562 4981297 An07g00080 Aspergillus niger uncharacterized protein XP_001391101.1 13864 D 5061 CDS An07g00090 4981293 complement(15828..16835) IV 1 NT_166523.1 Similarity: the ORF and the ren71 gene of S. aureofaciens show N-terminal similarity (up to amino acid 278 of the ORF). The aligned sequences include many gaps.; Title: similarity to hypothetical meta-cleavage compound hydrolase gene ren71 - Streptomyces aureofaciens; uncharacterized protein 16835 4981293 An07g00090 Aspergillus niger uncharacterized protein XP_001391102.1 15828 R 5061 CDS An07g00100 4981304 17361..18788 IV 1 NT_166523.1 Catalytic activity: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3.; Pathway: styrene degradation; arginine and proline metabolism; phenylalanine metabolism; tryptophan metabolism; cyanoamino acid metabolism.; Remark: the amidase from Rhodococcus sp. is an apparent homodimer, each molecule of which has an Mr of 48,554; it has a specific activity of 16. 5 mumol of S(+)-2-phenylpropionic acid formed per min per mg of enzyme from the racemic amide under our conditions.; Similarity: belongs to indoleacetamide hydrolase family.; Title: strong similarity to enantiomer-selective amidase amdA - Rhodococcus sp.; See PMID 1938876; uncharacterized protein 18788 4981304 An07g00100 Aspergillus niger uncharacterized protein XP_001391103.1 17361 D 5061 CDS An07g00110 84591232 complement(18920..20167) IV 1 NT_166523.1 Catalytic activity: N-(6-aminohexanoyl)-6-aminohexanoate + H2O = 2 6-aminohexanoate.; Remark: Flavobacterium sp. KI72 metabolizes 6-aminohexanoic acid cyclic dimer, a by-product of nylon manufacture, through two evolved enzymes, 6-aminohexanoic acid cyclic dimer hydrolase (EI) and 6-aminohexanoic acid linear oligomer hydrolase (EII).; Title: strong similarity to 6-aminohexanoate-dimer hydrolase EII nylB - Flavobacterium sp.; See PMID 2512123; See PMID 6646204; See PMID 1879421; uncharacterized protein 20167 84591232 An07g00110 Aspergillus niger uncharacterized protein XP_059600821.1 18920 R 5061 CDS An07g00120 84591233 complement(join(21445..21470,21604..21682,21804..21871,22017..22020)) IV 1 NT_166523.1 Title: questionable ORF; uncharacterized protein 22020 84591233 An07g00120 Aspergillus niger uncharacterized protein XP_059600822.1 21445 R 5061 CDS An07g00130 4981291 complement(22545..23159) IV 1 NT_166523.1 Similarity: belongs to the Escherichia coli ribosomal-protein-alanine N-acetyltransferase rimJ family.; Title: similarity to hypothetical conserved protein ynaD - Bacillus subtilis; uncharacterized protein 23159 4981291 An07g00130 Aspergillus niger uncharacterized protein XP_001391106.1 22545 R 5061 CDS An07g00140 84591234 complement(join(23587..23667,23742..23790,23862..23930,24325..24456,24858..24907)) IV 1 NT_166523.1 hypothetical protein 24907 84591234 An07g00140 Aspergillus niger hypothetical protein XP_059600823.1 23587 R 5061 CDS An07g00150 4981283 complement(join(25171..25544,25667..26031,26098..26436,26499..26829,26889..27057)) IV 1 NT_166523.1 Remark: bmr3 gene expression was dependent on the growth phase.; Remark: strong similarity to Aspergillus niger cDNA clone 3646 5', mRNA sequence.; Similarity: belongs to the multidrug-efflux transporter family.; Title: strong similarity to multidrug transporter bmr3 - Bacillus subtilis; See PMID 9023234; uncharacterized protein 27057 4981283 An07g00150 Aspergillus niger uncharacterized protein XP_001391108.3 25171 R 5061 CDS An07g00160 84591235 join(28147..28404,28487..28711,28825..29184,29273..29509) IV 1 NT_166523.1 Remark: mikimopine synthase and cucumopine synthase from Agrobacterium rhizogenes produced by a protein expression system using E. coli catalyzed the synthesis of mikimopine and cucumopine from L-histidine and alpha-ketoglutaric acid, requiring NADH as a cofactor.; Title: similarity to cucumopine synthase cus -Agrobacterium rhizogenes; See PMID 11223242; uncharacterized protein 29509 84591235 An07g00160 Aspergillus niger uncharacterized protein XP_059600824.1 28147 D 5061 CDS An07g00170 4981294 join(30698..30902,30935..31542,31609..32531,32592..33059,33111..33352,33561..33658) IV 1 NT_166523.1 hypothetical protein 33658 4981294 An07g00170 Aspergillus niger hypothetical protein XP_059600825.1 30698 D 5061 CDS An07g00180 84591236 complement(join(33939..33968,34009..34093,34203..34218,34248..34285,34468..34562)) IV 1 NT_166523.1 Title: questionable ORF; uncharacterized protein 34562 84591236 An07g00180 Aspergillus niger uncharacterized protein XP_059600826.1 33939 R 5061 CDS An07g00190 4981287 join(35653..35771,35825..35935,35984..36408,36439..36571,36628..36790) IV 1 NT_166523.1 Title: similarity to hypothetical methyltransferase AAO27746.2 - Fusarium sporotrichioides; uncharacterized protein 36790 4981287 An07g00190 Aspergillus niger uncharacterized protein XP_059600827.1 35653 D 5061 CDS An07g00200 4981276 complement(join(37171..37213,37394..37743,37805..38233)) IV 1 NT_166523.1 Remark: EstC Burkholderia gladioli was able to hydrolyze a variety of esterase substrates of low to medium carbonic acid chain length, but no triglycerides were hydrolyzed.; Title: similarity to esterase EstC - Burkholderia gladioli; See PMID 11152069; uncharacterized protein 38233 4981276 An07g00200 Aspergillus niger uncharacterized protein XP_001391113.3 37171 R 5061 CDS An07g00210 84591237 join(38611..38670,38968..39015,39378..39528,39614..39795) IV 1 NT_166523.1 hypothetical protein 39795 84591237 An07g00210 Aspergillus niger hypothetical protein XP_059600828.1 38611 D 5061 CDS An07g00220 4981301 join(39886..39941,40015..40213,40267..40303,40357..40577,40630..40853,40905..41032,41086..41441) IV 1 NT_166523.1 Remark: Pth11p functions at the cell cortex as an upstream effector of appressorium differentiation in response to surface cues.; Remark: inhibition of of the genes PTH2, PTH3, PTH11 and PTH12 results in the reduction or elimination of the pathogenic phenotype of the fungus. The genes are useful in the design of screens to identify inhibitors of the fungal pathogenic gene products.; Remark: similarity to integral membrane protein PTH11 - Magnaporthe grisea patent WO9913094-A2.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529; uncharacterized protein 41441 4981301 An07g00220 Aspergillus niger uncharacterized protein XP_001391115.3 39886 D 5061 CDS An07g00230 4981300 complement(join(41980..42935,43003..43452,43528..43576)) IV 1 NT_166523.1 Function: high affinity glucose transporter.; Localization: integral membrane protein.; Remark: disruption strains of HGT1 Kluyveromyces lactis showed much-reduced uptake of glucose at low concentrations and growth was particularly affected in low-glucose medium.; Remark: expression of HGT1 from Kluyveromyces lactis is constitutive (in contrast to RAG1, the major gene for low-affinity glucose uptake in K. lactis) and is controlled by several genes also known to affect expression of RAG1.; Similarity: belongs to the sugar transporter family.; Title: strong similarity to high affinity glucose transporter HGT1 - Kluyveromyces lactis; plasma membrane; See PMID 8830679; uncharacterized protein 43576 4981300 An07g00230 Aspergillus niger uncharacterized protein XP_001391116.1 41980 R 5061 CDS An07g00240 4981295 complement(44259..47006) IV 1 NT_166523.1 Catalytic activity: hydrolysis of terminal,non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.; Remark: RamA of Clostridium stercorarium hydrolysed p-nitrophenyl-alpha-L-rhamnopyranoside, naringin and hesperidin with a specific activity of 82, 1. 5 and 0. 46 U mg-1 respectively. Hydrolysis occurs by inversion of the anomeric configuration as detected using 1H-NMR, indicating a single displacement mechanism. Naringin was hydrolysed to rhamnose and prunin, which could further be degraded by incubation with a thermostable beta-glucosidase.; Title: strong similarity to alfa-L-rhamnosidase ramA - Clostridium stercorarium; See PMID 10632887; uncharacterized protein 47006 4981295 An07g00240 Aspergillus niger uncharacterized protein XP_001391117.1 44259 R 5061 CDS An07g00250 4981272 join(49092..49244,49364..50193,50247..50850) IV 1 NT_166523.1 Remark: putative ataxanthin synthetase.; Remark: strong similarity to astaxanthin synthetase from patent EP1035206-A/2 - Phaffia rhodozyma.; Title: strong similarity to astaxanthin synthetase from patent EP1035206-A - Phaffia rhodozyma; See PMID 11341317; uncharacterized protein 50850 4981272 An07g00250 Aspergillus niger uncharacterized protein XP_001391118.1 49092 D 5061 CDS An07g00260 4981273 join(51173..51262,51332..51627,51689..52385) IV 1 NT_166523.1 Title: strong similarity to hypothetical conserved protein CC0299 - Caulobacter crescentus; uncharacterized protein 52385 4981273 An07g00260 Aspergillus niger uncharacterized protein XP_059600829.1 51173 D 5061 CDS An07g00270 84591238 52755..52958 IV 1 NT_166523.1 Remark: the encoded protein shows also similarities to the C-terminus of An07g01660.; Title: similarity to hypothetical protein EAA59869.1 - Aspergillus nidulans; uncharacterized protein 52958 84591238 An07g00270 Aspergillus niger uncharacterized protein XP_059600830.1 52755 D 5061 CDS An07g00280 4981289 join(53272..53321,53379..53442,53515..54249) IV 1 NT_166523.1 Title: strong similarity to hypothetical host-specific AK-toxin Akt2 - Neurospora crassa; uncharacterized protein 54249 4981289 An07g00280 Aspergillus niger uncharacterized protein XP_001391121.3 53272 D 5061 CDS An07g00290 4981274 join(54509..54699,54764..55397) IV 1 NT_166523.1 Catalytic activity: 3-cis-Dodecenoyl-CoA = 2-trans-Dodecenoyl-CoA.; Pathway: fatty acid metabolism.; Remark: ECI1 S. cerevisiae encodes a Delta3-cis-Delta2-trans-enoyl-CoA isomerase that acts as an auxiliary enzyme in the beta-oxidation of (poly)unsaturated fatty acids.; Remark: alternative names YLR284c, EHD1.; Similarity: belongs to the enoyl-CoA hydratase/isomerase.; Title: strong similarity to delta3-cis-delta2-trans-enoyl-CoA isomerase Eci1 -Saccharomyces cerevisiae; peroxisome; See PMID 9813046; See PMID 9837886; uncharacterized protein 55397 4981274 An07g00290 Aspergillus niger uncharacterized protein XP_001391122.1 54509 D 5061 CDS An07g00300 4981296 complement(join(55595..55638,55725..55780,55961..57235,57393..57703)) IV 1 NT_166523.1 Function: probable efflux transporter. confers resistance to the azole derivative fluconazole (fcz).; Remark: FLR1 gene encodes a plasma membrane transporter of the major facilitator superfamily (MFS) conferring resistance to multiple drugs, in particular to benomyl.; Similarity: belongs to the benomyl/methotrexate resistance proteins.; Title: strong similarity to fluconazole resistance transporter Flr1 - Saccharomyces cerevisiae; See PMID 9235926; See PMID 10572257; See PMID 11162502; uncharacterized protein 57703 4981296 An07g00300 Aspergillus niger uncharacterized protein XP_001391123.3 55595 R 5061 CDS An07g00310 4981282 complement(join(57795..58343,58413..58574,58647..59164,59220..59533,59713..59814,60011..60111,60199..60266,60369..60454,60706..60773)) IV 1 NT_166523.1 Remark: BAT1 from rats exhibited a Na(+)-independent transport of cystine as well as basic and neutral amino acids with the properties of system b(0,+).; Similarity: belongs to the amino acid transporters.; Title: similarity to amino acid transporter BAT1 -Rattus norvegicus; See PMID 10506124; uncharacterized protein 60773 4981282 An07g00310 Aspergillus niger uncharacterized protein XP_001391124.3 57795 R 5061 CDS An07g00320 4981277 join(61088..61171,61322..61973,62030..62226) IV 1 NT_166523.1 Remark: expression induced by plant cell-wall proteins is controlled by both carbon and nitrogen catabolite repression. Glucose on its own represses acp1 expression while ammonium repression requires the simultaneous presence of a carbon source.; Title: strong similarity to non-aspartyl acid protease acp1 - Sclerotinia sclerotiorum; extracellular/secretion proteins; See PMID 11238979; uncharacterized protein 62226 4981277 An07g00320 Aspergillus niger uncharacterized protein XP_001391125.1 61088 D 5061 CDS An07g00330 4981290 complement(join(62888..63045,63097..63384,63434..63587)) IV 1 NT_166523.1 Remark: alternate name in S. cerevisiae = YHR211W.; Title: weak similarity to flocculation protein Flo5 - Saccharomyces cerevisiae; uncharacterized protein 63587 4981290 An07g00330 Aspergillus niger uncharacterized protein XP_001391126.1 62888 R 5061 CDS An07g00340 84591239 join(64617..64757,64906..64916,64958..65015,65064..65097,65208..65293) IV 1 NT_166523.1 hypothetical protein 65293 84591239 An07g00340 Aspergillus niger hypothetical protein XP_059600831.1 64617 D 5061 CDS An07g00350 4981281 join(66285..67279,67329..68640) IV 1 NT_166523.1 Catalytic activity: hydrolysis of terminal,non-reducing 1,4-linked alpha-D-glucose residues with release of alpha-D-glucose.; Pathway: galactose metabolism.; Remark: alpha-glucosidase II from Bacillus thermoamyloliquefaciens make each subunit of 3 secondary structural regions, i. e., one N-terminal beta region, one central alpha/beta region with two catalytic residues Asp407 and Asp484, and one C-terminal beta region.; Similarity: belongs to the alpha-glucosidases.; Title: similarity to alpha-glucosidase - Bacillus thermoamyloliquefaciens; See PMID 10945254; uncharacterized protein 68640 4981281 An07g00350 Aspergillus niger uncharacterized protein XP_059600832.1 66285 D 5061 CDS An07g00360 4981307 complement(join(68815..69588,69650..70192,70253..70399,70463..70682,70855..70901)) IV 1 NT_166523.1 Remark: TPO1 encodes a polyamine transport protein on the vacuolar membrane in yeast. TPO1 and TPO4 recognized specificaly spermidine and spermine.; Remark: alternative name is YLL028W.; Similarity: belongs to the family of the major facilitator superfamily (MFS-MDR).; Title: strong similarity to polyamine transport protein Tpo1 - Saccharomyces cerevisiae; vacuole; See PMID 9920864; See PMID 10585849; See PMID 11171066; uncharacterized protein 70901 4981307 An07g00360 Aspergillus niger uncharacterized protein XP_001391129.3 68815 R 5061 CDS An07g00370 4981308 complement(join(71402..71692,71757..72046,72101..72757,72875..72958,73010..73220)) IV 1 NT_166523.1 Remark: DAL4 has similarity to the uracil permease component encoded by FUR4.; Remark: alternative name is YIR028w.; Similarity: belongs to the uracil/allantoin permase family of the major facilitator superfamily (MFS).; Title: strong similarity to allantoin transport protein Dal4 - Saccharomyces cerevisiae; See PMID 1293888; uncharacterized protein 73220 4981308 An07g00370 Aspergillus niger uncharacterized protein XP_059600833.1 71402 R 5061 CDS An07g00380 4981309 join(73637..73969,74035..74107,74164..76037) IV 1 NT_166523.1 Remark: Hydantoinase is an enzyme for transforming 5-substd. hydantoin.; Remark: strong similarity to hydantoinase patent JP03251176-A - Pseudomonas NS 671.; Title: strong similarity to hydantoinase from patent JP03251176-A - Pseudomonas sp.; See PMID 1732229; uncharacterized protein 76037 4981309 An07g00380 Aspergillus niger uncharacterized protein XP_001391131.3 73637 D 5061 CDS An07g00390 84591240 join(76096..76143,76214..76417,76466..76939) IV 1 NT_166523.1 Title: similarity to hypothetical protein BH1883 -Bacillus halodurans; uncharacterized protein 76939 84591240 An07g00390 Aspergillus niger uncharacterized protein XP_059600834.1 76096 D 5061 CDS An07g00400 4981311 complement(77156..78148) IV 1 NT_166523.1 Similarity: belongs to the short-chain alcohol dehydrogenase family.; Title: strong similarity to protein from patent WO0065067-A - Homo sapiens; uncharacterized protein 78148 4981311 An07g00400 Aspergillus niger uncharacterized protein XP_001391133.1 77156 R 5061 CDS An07g00410 84591241 complement(78375..78641) IV 1 NT_166523.1 hypothetical protein 78641 84591241 An07g00410 Aspergillus niger hypothetical protein XP_059600835.1 78375 R 5061 CDS An07g00420 10098305 join(78976..79251,79334..79582) IV 1 NT_166523.1 Remark: only the N-terminal first 100 amino acids are matching.; Title: weak similarity to protein fragment SEQ ID NO:58643 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 79582 10098305 An07g00420 Aspergillus niger uncharacterized protein XP_059600836.1 78976 D 5061 CDS An07g00430 84591242 complement(join(80386..80498,80580..80666,80777..80832,80904..80972,81074..81174)) IV 1 NT_166523.1 hypothetical protein 81174 84591242 An07g00430 Aspergillus niger hypothetical protein XP_059600837.1 80386 R 5061 CDS An07g00440 4981315 81570..82826 IV 1 NT_166523.1 Catalytic activity: triacylglycerol + H2O = diacylglycerol + a carboxylate; diacylglycerol + H2O = monoacylglycerol + a carboxylate.; Pathway: glycerolipid metabolism.; Remark: LIP2 from Candida albicans is only expressed in media lacking lipids.; Similarity: belongs to the lipase family from Candida albicans.; Title: strong similarity to secretory lipase LIP2 -Candida albicans; See PMID 11131027; uncharacterized protein 82826 4981315 An07g00440 Aspergillus niger uncharacterized protein XP_001391137.1 81570 D 5061 CDS An07g00450 4981316 complement(join(83056..83273,83329..84546,84597..84951)) IV 1 NT_166523.1 Catalytic activity: beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2.; Pathway: pentose phosphate cycle.; Remark: also strong similarity to glucose oxidase GO2 from Aspergillus niger.; Remark: glucose oxidase from P. amagasakiense shows a high degree of identity (66%) and 79% similarity to glucose oxidase from Aspergillus niger, and is a member of the glucose-methanol-choline (GMC) oxidoreductase family. The overall structure can be divided into five distinct sequence regions: FAD-binding domain, extended FAD-binding domain, flavin attachment loop and intermediate region, FAD covering lid, and substrate-binding domain.; Similarity: belongs to the GMC oxidoreductase family.; Title: strong similarity to glucose oxidase GOX -Penicillium amagasakiense; See PMID 9523716; uncharacterized protein 84951 4981316 An07g00450 Aspergillus niger uncharacterized protein XP_001391138.1 83056 R 5061 CDS An07g00460 84591243 complement(join(85982..86110,86222..86317,86460..86495)) IV 1 NT_166523.1 hypothetical protein 86495 84591243 An07g00460 Aspergillus niger hypothetical protein XP_059600838.1 85982 R 5061 CDS An07g00470 4981318 join(86711..87949,88002..88137,88191..88668,88719..88917) IV 1 NT_166523.1 Catalytic activity: preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5-15 residues.; Remark: Aspergillus fumigatus produces an 82 kDa intracellular metalloproteinase that hydrolyses the Pz-peptide,4-phenylazobenzyloxycarbonyl-Pro-Leu-Gly-Pro-Ar g, a typical substrate of members of the thimet oligopeptidase family which is ubiquitously distributed across animal species.; Similarity: belongs to the Zn-dependent oligopeptidases.; Title: strong similarity to cytoplasmic metalloproteinase mepB - Aspergillus fumigatus; See PMID 9245813; uncharacterized protein 88917 4981318 An07g00470 Aspergillus niger uncharacterized protein XP_001391140.3 86711 D 5061 CDS An07g00480 4981319 join(89252..89351,89413..90071) IV 1 NT_166523.1 Title: weak similarity to appressorium formation protein CAD2 - Colletotrichum lagenarium; uncharacterized protein 90071 4981319 An07g00480 Aspergillus niger uncharacterized protein XP_001391141.1 89252 D 5061 CDS An07g00490 84591244 join(90994..91011,91136..91296,91395..91490,91609..91768) IV 1 NT_166523.1 hypothetical protein 91768 84591244 An07g00490 Aspergillus niger hypothetical protein XP_059600839.1 90994 D 5061 CDS An07g00500 84591245 complement(join(91910..92137,92170..92223)) IV 1 NT_166523.1 hypothetical protein 92223 84591245 An07g00500 Aspergillus niger hypothetical protein XP_059600840.1 91910 R 5061 CDS An07g00510 4981322 92473..93300 IV 1 NT_166523.1 Remark: the similarity is only found in the N-terminal half of the homolog portein.; Title: similarity to hypothetical lipoprotein SC4A2.13c - Streptomyces coelicolor; uncharacterized protein 93300 4981322 An07g00510 Aspergillus niger uncharacterized protein XP_001391144.1 92473 D 5061 CDS An07g00520 4981323 complement(join(94116..94454,94515..94618,94678..94882)) IV 1 NT_166523.1 Catalytic activity: RX + glutathione = HX + R-S-glutathione.; Remark: glutathione s-transferases are a group of enzymes of broad specificity. R may be an aliphatic,aromatic or heterocyclic group. X may be a sulfate, nitrite or halide group. Also catalyses the addition of aliphatic epoxides and arene oxides to glutathione; the reduction of polyol nitrate by glutathione to polyol and nitrite; certain isomerization reactions and disulfide interchange.; Remark: the A. thaliana enzyme is soluble and constitutively expressed in vegetative rosettes, but is under developmental control during the transition to bolting and flowering.; Similarity: belongs to the glutathione transferase.; Title: strong similarity to glutathione transferase GTH5 - Arabidopsis thaliana; See PMID 8375395; uncharacterized protein 94882 4981323 An07g00520 Aspergillus niger uncharacterized protein XP_001391145.1 94116 R 5061 CDS An07g00530 4981324 complement(join(95169..95362,95422..95819,95912..96045,96109..96443,96515..96533,96619..97164)) IV 1 NT_166523.1 Remark: The ability to detoxify pisatin, a phytoalexin produced by garden pea (Pisum sativum), is controlled by a family of PDA (pisatin demethylating ability) genes in the phytopathogenic fungus Nectria haematococa, MP (mating population) VI.; Similarity: belongs to the cytochrome P450 family proteins.; Title: strong similarity to pisatin demethylase PDA6-1 - Nectria haematococca; See PMID 8076822; uncharacterized protein 97164 4981324 An07g00530 Aspergillus niger uncharacterized protein XP_059600841.1 95169 R 5061 CDS An07g00540 4981325 join(97669..97689,97739..98257,98322..98498,98546..98935) IV 1 NT_166523.1 Title: similarity to hypothetical nucleoside-diphosphate-sugar epimerase AAM31397.1 -Methanosarcina mazei; uncharacterized protein 98935 4981325 An07g00540 Aspergillus niger uncharacterized protein XP_059600842.1 97669 D 5061 CDS An07g00550 4981326 complement(join(99032..99180,99284..99698,99751..100593)) IV 1 NT_166523.1 Catalytic activity: salicylate + NADH + O2 = catechol + NAD+ + H2O + CO2.; Pathway: phenylalanine metabolism; nitorobenzene degradation.; Remark: gene nahG of naphthalene/salicylate catabolic plasmid NAH7 encodes a protein of molecular weight 45,000, salicylate hydroxylase. This enzyme catalyzes the formation of catechol from salicylate, a key intermediate in naphthalene catabolism.; Similarity: belongs to the 2-octaprenyl-6-metoxyphenol hydroxylase and related FAD-dependent oxidoreductases.; Title: strong similarity to salicylate hydroxylase nahG - Pseudomonas putida; See PMID 2363715; See PMID 1993181; uncharacterized protein 100593 4981326 An07g00550 Aspergillus niger uncharacterized protein XP_001391148.3 99032 R 5061 CDS An07g00560 84591246 join(100696..100715,100787..100948,101034..101096,101197..101318,101506..101780) IV 1 NT_166523.1 hypothetical protein 101780 84591246 An07g00560 Aspergillus niger hypothetical protein XP_059600843.1 100696 D 5061 CDS An07g00570 4981328 join(101971..102144,102202..102389,102444..102628,102682..102799,102851..102918,102975..103005,103057..103390) IV 1 NT_166523.1 Remark: for Pth11 from M. grisea it is suggested that it functions at the cell cortex as an upstream effector of appressorium differentiation in response to surface cues.; Remark: only the N-terminal half of PTH11 is matching this ORF. The ORF is about 200 amino acids shorter.; Remark: related to unknown integral membrane protein pth11 - Neurospora crassa with approximately the same lenght.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529; uncharacterized protein 103390 4981328 An07g00570 Aspergillus niger uncharacterized protein XP_001391150.1 101971 D 5061 CDS An07g00580 4981329 105005..107050 IV 1 NT_166523.1 Remark: similarity to Bacillus subtilis serine protease SP1 (YUXL) patent WO9903984-A2.; Title: similarity to serine protease SP1 from patent WO9903984-A2 - Bacillus subtilis; uncharacterized protein 107050 4981329 An07g00580 Aspergillus niger uncharacterized protein XP_001391151.1 105005 D 5061 CDS An07g00590 4981330 complement(join(108836..109682,109734..109783)) IV 1 NT_166523.1 Remark: the Japanese pear pathotype of Alternaria alternata produces host-specific AK-toxin and causes black spot of Japanese pear.; Title: strong similarity to hypothetical protein required for biosynthesis of the host-specific AK-toxin Akt2 - Alternaria alternata; See PMID 10432635; See PMID 10975654; uncharacterized protein 109783 4981330 An07g00590 Aspergillus niger uncharacterized protein XP_001391152.3 108836 R 5061 CDS An07g00600 84591247 complement(join(109901..110047,110101..110551,110633..110652)) IV 1 NT_166523.1 Remark: the encoded protein shows also similarities to the N-terminus of An11g03950.; Title: strong similarity to hypothetical protein EAA59869.1 - Aspergillus nidulans; uncharacterized protein 110652 84591247 An07g00600 Aspergillus niger uncharacterized protein XP_059600844.1 109901 R 5061 CDS An07g00620 4981333 join(111662..113181,113233..113716) IV 1 NT_166523.1 Remark: the PPR1 gene of S. cerevisiae controls the transcription of two unlinked structural genes URA1 and URA3.; Similarity: belongs to the unassigned GAL4-type zinc cluster proteins; GAL4 zinc binuclear cluster homology.; Title: similarity to regulator protein Ppr1 -Saccharomyces cerevisiae; See PMID 6096561; See PMID 6096562; uncharacterized protein 113716 4981333 An07g00620 Aspergillus niger uncharacterized protein XP_001391154.1 111662 D 5061 CDS An07g00630 4981334 complement(join(113948..114120,114153..114252,114289..114794,114862..115027)) IV 1 NT_166523.1 Remark: YLL057c is involved in sulphonate catabolism. Purified recombinant yeast protein is shown to be an Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase.; Title: similarity to Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase YLL057c -Saccharomyces cerevisiae; See PMID 10482536; See PMID 11223942; uncharacterized protein 115027 4981334 An07g00630 Aspergillus niger uncharacterized protein XP_059600845.1 113948 R 5061 CDS An07g00640 4981335 complement(115747..116592) IV 1 NT_166523.1 Remark: only the threonin and serin rich region is matching.; Title: weak similarity to hypothetical protein YDL037c - Saccharomyces cerevisiae; uncharacterized protein 116592 4981335 An07g00640 Aspergillus niger uncharacterized protein XP_001391156.1 115747 R 5061 CDS An07g00650 84591248 complement(join(117020..117079,117154..117384)) IV 1 NT_166523.1 hypothetical protein 117384 84591248 An07g00650 Aspergillus niger hypothetical protein XP_059600846.1 117020 R 5061 CDS An07g00660 84591249 complement(join(117712..117838,118181..118350)) IV 1 NT_166523.1 hypothetical protein 118350 84591249 An07g00660 Aspergillus niger hypothetical protein XP_059600847.1 117712 R 5061 CDS An07g00670 4981338 complement(join(118633..119001,119056..120002,120066..120682,120755..120786)) IV 1 NT_166523.1 Remark: nit-4, a pathway-specific regulatory gene in the nitrogen circuit of Neurospora crassa, is required for the expression of nit-3 and nit-6, the structural genes which encode nitrate and nitrite reductase.; Similarity: belongs to unassigned GAL4-type zinc cluster proteins.; Title: similarity to nitrogen assimilation regulatory protein nit-4 - Neurospora crassa; nucleus; See PMID 1840634; uncharacterized protein 120786 4981338 An07g00670 Aspergillus niger uncharacterized protein XP_059600848.1 118633 R 5061 CDS An07g00680 4981339 complement(121198..122253) IV 1 NT_166523.1 Catalytic activity: L-threonine = glycine + acetaldehyde.; Pathway: glycine, serine and threonine metabolism.; Remark: strong similarity to Pseudomonas putida threonine aldolase patent JP03277282-A.; Remark: the enzyme, requiring pyridoxal 5'-phosphate as a coenzyme, is strictly L specific at the alpha position, whereas it cannot distinguish between threo and erythro forms at the beta position. In addition to threonine, the enzyme also acts on various other L-beta-hydroxy-alpha-amino acids, including L-beta-3,4-dihydroxyphenylserine, L-beta-3,4-methylenedioxyphenylserine, and L-beta-phenylserine.; Similarity: belongs to the threonine aldolase family.; Title: strong similarity to low specificity L-threonine aldolase from patent JP03277282-A - Pseudomonas putida; See PMID 9464392; uncharacterized protein 122253 4981339 An07g00680 Aspergillus niger uncharacterized protein XP_001391160.1 121198 R 5061 CDS An07g00690 84591250 complement(join(122617..122803,123167..123471)) IV 1 NT_166523.1 hypothetical protein 123471 84591250 An07g00690 Aspergillus niger hypothetical protein XP_059600849.1 122617 R 5061 CDS An07g00700 4981341 complement(123640..124746) IV 1 NT_166523.1 Remark: the ORF functions putative as dioxygenase.; Title: similarity to sequence SEQ ID NO:1465 from patent WO200294867-A2 - Photorhabdus luminescens; uncharacterized protein 124746 4981341 An07g00700 Aspergillus niger uncharacterized protein XP_001391162.1 123640 R 5061 CDS An07g00710 84591251 complement(125597..125899) IV 1 NT_166523.1 hypothetical protein 125899 84591251 An07g00710 Aspergillus niger hypothetical protein XP_059600850.1 125597 R 5061 CDS An07g00720 84591252 join(125926..126021,126114..126138,126204..126342,126427..126536,126722..126788,126956..127009,127143..127257,127333..127404,127490..127614,127883..127944,128614..128855) IV 1 NT_166523.1 Remark: only a small domain is matching.; Title: weak similarity to activating transcription factor 2 ATF2 - Xenopus laevis; uncharacterized protein 128855 84591252 An07g00720 Aspergillus niger uncharacterized protein XP_059600851.1 125926 D 5061 CDS An07g00730 4981344 complement(join(129938..130241,130305..130582,130664..130896,130957..131014)) IV 1 NT_166523.1 Similarity: to dehydrogenases with different specificities.; Title: similarity to hypothetical beta-hydroxybutyrate dehydrogenase hbdh1 - Ralstonia eutropha; uncharacterized protein 131014 4981344 An07g00730 Aspergillus niger uncharacterized protein XP_001391165.1 129938 R 5061 CDS An07g00740 84591253 join(131347..131352,131454..131609,131658..131750) IV 1 NT_166523.1 hypothetical protein 131750 84591253 An07g00740 Aspergillus niger hypothetical protein XP_059600852.1 131347 D 5061 CDS An07g00750 4981346 complement(join(132027..132211,132256..132442,132489..133377,133437..133504,133574..133606)) IV 1 NT_166523.1 Remark: inactivation of the amdR A. oryzae gene results in the inability to grow on gamma-amino-butyric acid (GABA) as a carbon and/or nitrogen source indicating that GABA utilization is amdR-dependent in A. oryzae as it is in A. nidulans.; Title: similarity to transcription regulator amdR -Aspergillus oryzae; See PMID 1452021; uncharacterized protein 133606 4981346 An07g00750 Aspergillus niger uncharacterized protein XP_059600853.1 132027 R 5061 CDS An07g00760 4981347 complement(134077..135330) IV 1 NT_166523.1 Remark: strong similarity to formyl-CoA transferase of Oxalobacter formigenes patent WO9816632-A1.; Remark: the Oxalobacter enzyme, together with oxalyl-CoA decarboxylase (V34839), converts oxalate to carbon dioxide and formate (in presence of oxalyl-coenzyme A). O. formigenes is an oxalate-dependent obligate anaerobic symbiont, present in the intestines of vertebrates, and involved in regulation of oxalic acid absorption.; Similarity: to predicted acyl-CoA transferases/carnitine dehydratases.; Title: strong similarity to formyl-CoA transferase from patent WO9816632-A1 - Oxalobacter formigenes; See PMID 8125343; uncharacterized protein 135330 4981347 An07g00760 Aspergillus niger uncharacterized protein XP_001391168.1 134077 R 5061 CDS An07g00770 84591254 join(135741..135797,135896..135941,136037..136317,136409..136468,136576..136686,136846..136989,137116..137289) IV 1 NT_166523.1 hypothetical protein 137289 84591254 An07g00770 Aspergillus niger hypothetical protein XP_059600854.1 135741 D 5061 CDS An07g00780 4981349 join(137469..137593,137648..138382,138441..138725,138779..138944) IV 1 NT_166523.1 Remark: human MCT2 mRNA expression was restricted in normal human tissues but widely expressed in cancer cell lines, suggesting that MCT2 may be pre-translationally regulated in neoplasia.; Remark: the transport of pyruvate and lactate across cellular membranes is an essential process in mammalian cells and is mediated by the H+/monocarboxylate transporters (MCTs).; Remark: the unique biochemical feature of human MCT2 is its high affinity for the transport of pyruvate (apparent Km of 25 microM), implying that it is a primary pyruvate transporter in man.; Title: strong similarity to monocarboxylate transporter 2 hMCT2 - Homo sapiens; See PMID 9425115; See PMID 9786900; See PMID 10510291; uncharacterized protein 138944 4981349 An07g00780 Aspergillus niger uncharacterized protein XP_059600855.1 137469 D 5061 CDS An07g00790 4981350 join(139451..140253,140303..140528,140585..140788) IV 1 NT_166523.1 Remark: choline monooxygenase (CMO) catalyzes the committing step in the synthesis of glycine betaine, an osmoprotectant accumulated by many plants in response to salinity and drought.; Remark: strong similarity to Sugarbeet choline monooxygenase patent WO9830702-A2.; Similarity: belongs to the Rieske [2Fe-2S] protein family.; Title: strong similarity to choline monooxygenase from patent WO9830702-A2 - Beta vulgaris; See PMID 9489025; uncharacterized protein 140788 4981350 An07g00790 Aspergillus niger uncharacterized protein XP_001391171.1 139451 D 5061 CDS An07g00800 84591255 join(141476..141670,141730..142082,142134..142304,142356..142640,142688..143130,143307..143501,143538..143644) IV 1 NT_166523.1 Catalytic activity: 2 geranylgeranyl diphosphate = pyrophosphate + prephytoene diphosphate.; Pathway: sterol biosynthesis; terpenoid biosynthesis.; Remark: RNA measurements showed that the level of al-2 mRNA increased over 30-fold in photoinduced mycelia compared with dark-grown mycelia.; Title: strong similarity to geranylgeranyl diphosphate geranylgeranyltransferase al-2 - Neurospora crassa; See PMID 8163509; uncharacterized protein 143644 84591255 An07g00800 Aspergillus niger uncharacterized protein XP_059600856.1 141476 D 5061 CDS An07g00810 4981352 join(144162..144293,144346..>145134) IV 1 NT_166523.1 Remark: C-terminal truncated ORF due to end of contig.; Similarity: shows weak similarity to bacteriochlorophyll synthases.; Title: similarity to hypothetical protein B24P7.350 - Neurospora crassa [truncated ORF]; uncharacterized protein 145134 4981352 An07g00810 Aspergillus niger uncharacterized protein XP_001391173.3 144162 D 5061 CDS An07g00820 4981353 complement(join(145780..146877,146945..147115)) IV 1 NT_166523.1 Function: xenA of P. putida removes central or terminal nitro-groups from nitroglycerin as nitrite.; Similarity: contains FMN oxidoreductase domain.; Similarity: shows much higher similarity to probable nadh-dependent flavin oxidoreductase of S. pombe.; Title: similarity to xenobiotic reductase A xenA -Pseudomonas putida; See PMID 10515912; uncharacterized protein 147115 4981353 An07g00820 Aspergillus niger uncharacterized protein XP_001391174.1 145780 R 5061 CDS An07g00830 84591256 complement(join(147193..147412,147851..147917,148402..148525)) IV 1 NT_166523.1 Title: questionable ORF; uncharacterized protein 148525 84591256 An07g00830 Aspergillus niger uncharacterized protein XP_059606091.1 147193 R 5061 CDS An07g00840 4981356 join(149092..149391,149484..149576) IV 1 NT_166523.1 Similarity: shows similarity to proteins containing Zn(2)-Cys(6) binuclear cluster.; hypothetical protein 149576 4981356 An07g00840 Aspergillus niger hypothetical protein XP_059606092.1 149092 D 5061 CDS An07g00850 84591257 149665..150783 IV 1 NT_166523.1 hypothetical protein 150783 84591257 An07g00850 Aspergillus niger hypothetical protein XP_059606093.1 149665 D 5061 CDS An07g00860 4981357 complement(join(150917..151404,151466..151708,151769..151940)) IV 1 NT_166523.1 Function: S. cerevisiae RTA1 gene is involved in 7-aminocholesterol resistance.; Remark: alternate names for RTA1 are protein G7811 and protein YGR213c.; Remark: seems to be a duplication of ORF440WK.; Similarity: shows strong similarity to hypothetical proteins of S. cerevisiae.; Title: similarity to 7-aminocholesterol resistance protein Rta1 - Saccharomyces cerevisiae; plasma membrane; See PMID 8660468; uncharacterized protein 151940 4981357 An07g00860 Aspergillus niger uncharacterized protein XP_001391178.1 150917 R 5061 CDS An07g00870 84591258 complement(join(152418..152500,152548..152748,152831..152910,153177..153351,153446..153503)) IV 1 NT_166523.1 Remark: ORF might be questionable.; hypothetical protein 153503 84591258 An07g00870 Aspergillus niger hypothetical protein XP_059606094.1 152418 R 5061 CDS An07g00880 4981359 154518..156278 IV 1 NT_166523.1 Localization: ankyrins are located in the cytoskeleton.; Remark: most of the ankyrins show alternative splicing.; Similarity: shows similarity to ankyrin domains of corresponding proteins.; Title: weak similarity to ankyrin 1 ANK1 - Homo sapiens; uncharacterized protein 156278 4981359 An07g00880 Aspergillus niger uncharacterized protein XP_001391180.1 154518 D 5061 CDS An07g00900 10098316 complement(join(156733..160415,160455..161145)) IV 1 NT_166523.1 Title: similarity to hypothetical retrotransposon Tto1 - Nicotiana tabacum; See PMID 8624443; uncharacterized protein 161145 10098316 An07g00900 Aspergillus niger uncharacterized protein XP_059606095.1 156733 R 5061 CDS An07g00905 4981361 complement(161523..162377) IV 1 NT_166523.1 Title: similarity to hypothetical protein B8J22.030 - Neurospora crassa; uncharacterized protein 162377 4981361 An07g00905 Aspergillus niger uncharacterized protein XP_001391182.1 161523 R 5061 CDS An07g00930 4981362 complement(join(162974..163383,163455..163938)) IV 1 NT_166523.1 Function: putative metallo-beta-lactamase because of corresponding pfam-domain.; Similarity: shows similarity to hydrolases including glyoxylases.; Similarity: shows strong similarity to several hypothetical proteins of different species.; Title: strong similarity to hypothetical protein PA2915 - Pseudomonas aeruginosa; uncharacterized protein 163938 4981362 An07g00930 Aspergillus niger uncharacterized protein XP_001391183.1 162974 R 5061 CDS An07g00940 4981363 complement(join(164974..165336,165385..165724,165787..165935)) IV 1 NT_166523.1 Catalytic activity: converts thiosulfate + cyanide <=> sulfite + thiocyanate.; Function: transferring sulfur-containing groups.; Remark: alternative names are rhodanese, thiosulfate cyanide transsulfurase and thiosulfate thiotransferase.; Similarity: shows similarity to several thiosulfate sulfurtransferase, because of corresponding pfam-domain.; Title: strong similarity to hypothetical thiosulfate sulfurtransferase - Gallus gallus; See PMID 2275748; uncharacterized protein 165935 4981363 An07g00940 Aspergillus niger uncharacterized protein XP_059606096.1 164974 R 5061 CDS An07g00950 4981364 complement(join(166538..166942,166999..167521,167575..167684,167765..167842)) IV 1 NT_166523.1 Catalytic activity: the C. albicans homolog CAA31962. 1 preferential cleaves at the carboxyl of hydrophobic amino acids, but fails to cleave 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 of insulin B chain. Activates trypsinogen, and degrades keratin.; Repression: this C. albicans endopeptidase is inhibited by pepstatin, but not by methyl 2-diazoacetamido-hexanoate or 1,2-epoxy-3-(P-nitrophenoxy)propane.; Similarity: belongs to peptidase family A1.; Title: similarity to aspartyl proteinase candidapepsin - Candida albicans; See PMID 2646602; uncharacterized protein 167842 4981364 An07g00950 Aspergillus niger uncharacterized protein XP_059606097.1 166538 R 5061 CDS An07g00960 84591259 complement(join(168232..168310,168407..168462)) IV 1 NT_166523.1 Remark: ORF might be questionable.; hypothetical protein 168462 84591259 An07g00960 Aspergillus niger hypothetical protein XP_059606098.1 168232 R 5061 CDS An07g00970 4981366 complement(join(168613..169073,169130..169378,169440..169608)) IV 1 NT_166523.1 Function: S. cerevisiae RTA1 gene is involved in 7-aminocholesterol resistance.; Remark: alternate names for RTA1 are protein G7811 and protein YGR213c.; Remark: seems to be a duplication of ORF515WS.; Similarity: shows strong similarity to hypothetical proteins of S. cerevisiae.; Title: similarity to 7-aminocholesterol resistance protein Rta1 - Saccharomyces cerevisiae; plasma membrane; See PMID 8660468; uncharacterized protein 169608 4981366 An07g00970 Aspergillus niger uncharacterized protein XP_001391187.1 168613 R 5061 CDS An07g00980 4981367 complement(170594..172300) IV 1 NT_166523.1 Function: probable sugar (and other) transporter,contains corresponding pfam-domain.; Localization: probable membrane protein, contains 4 transmembranal regions.; Title: strong similarity to hypothetical membrane protein YIL166c - Saccharomyces cerevisiae; uncharacterized protein 172300 4981367 An07g00980 Aspergillus niger uncharacterized protein XP_001391188.1 170594 R 5061 CDS An07g00990 84591260 complement(join(172330..172560,172673..172738,172850..172982,173070..173140)) IV 1 NT_166523.1 hypothetical protein 173140 84591260 An07g00990 Aspergillus niger hypothetical protein XP_059606099.1 172330 R 5061 CDS An07g01000 4981369 complement(join(173170..173618,173676..173889,173950..174083,174141..174352,174403..174481,174651..174987)) IV 1 NT_166523.1 Function: In A. niger cultures which were shifted from growth on sucrose to growth on apple pectin as a carbon source, the expression of the rhamnogalacturonan hydrolase A gene (rhgA) was transiently induced after 3 h of growth on apple pectin.; Localization: might be located in the plasma membrane.; Remark: possible sequencing error around pos. 102865.; Similarity: There exist two rhamnogalacturonases in A. niger rhgA and rhgB, but the ORF is not identical to one of them.; Title: strong similarity to rhamnogalacturonase rhgA - Aspergillus niger [putative sequencing error]; See PMID 9212401; uncharacterized protein 174987 4981369 An07g01000 Aspergillus niger uncharacterized protein XP_059606100.1 173170 R 5061 CDS An07g01010 4981370 175717..177192 IV 1 NT_166523.1 Function: sulphamidase is an exoglycosidase involved in the degradation of heparan sulfate.; Remark: alternative names are N-sulphoglucosamine sulphohydrolase.; Title: strong similarity to sulphamidase - Mus musculus; extracellular/secretion proteins; See PMID 10818207; uncharacterized protein 177192 4981370 An07g01010 Aspergillus niger uncharacterized protein XP_001391191.1 175717 D 5061 CDS An07g01020 84591261 join(177445..177542,177810..178023) IV 1 NT_166523.1 Remark: ORF might be questionable.; hypothetical protein 178023 84591261 An07g01020 Aspergillus niger hypothetical protein XP_059606101.1 177445 D 5061 CDS An07g01030 4981372 join(179481..180076,180150..180663,180725..180848,180920..181032,181088..181523,181584..182030,182093..183336,183399..183491,183632..183874) IV 1 NT_166523.1 Function: FUM5 polyketide synthase gene is required for biosynthesis of fumonisin mycotoxins.; Similarity: shows strong similarity in the aminoterminus to FUM5, but lacks the carboxyterminal part.; Title: strong similarity to polyketide synthase FUM5 - Gibberella moniliformis; See PMID 10413619; See PMID 10802562; See PMID 10872449; uncharacterized protein 183874 4981372 An07g01030 Aspergillus niger uncharacterized protein XP_059606102.1 179481 D 5061 CDS An07g01040 84591262 join(183899..184137,184223..184364) IV 1 NT_166523.1 Similarity: shows similarity to proteins containing phosphopantetheine attachment sites.; Title: weak similarity to polyketide synthase Fum5 -Gibberella moniliformis; uncharacterized protein 184364 84591262 An07g01040 Aspergillus niger uncharacterized protein XP_059606103.1 183899 D 5061 CDS An07g01050 4981374 complement(join(184711..184821,184919..185173,185261..185529,185580..185875,186145..186302,186626..186871,186953..187069,187178..187195)) IV 1 NT_166523.1 Title: weak similarity to hypothetical protein encoded by An05g01720 - Aspergillus niger; uncharacterized protein 187195 4981374 An07g01050 Aspergillus niger uncharacterized protein XP_059606104.1 184711 R 5061 CDS An07g01060 4981375 join(189253..189547,189640..190298) IV 1 NT_166523.1 Remark: possible functions for the CIH1 protein in the establishment and maintenance of biotrophy are discussed.; Title: similarity to CIH1 gene for intracellular hyphae protein 1 - Colletotrichum lindemuthianum; See PMID 9721685; uncharacterized protein 190298 4981375 An07g01060 Aspergillus niger uncharacterized protein XP_001391196.3 189253 D 5061 CDS An07g01070 4981376 join(191720..192299,192438..192790) IV 1 NT_166523.1 hypothetical protein 192790 4981376 An07g01070 Aspergillus niger hypothetical protein XP_059606105.1 191720 D 5061 CDS An07g01080 84591263 complement(join(195154..195511,195679..195735,195813..195925,195971..196035,196115..196329,196418..196552,196601..196692)) IV 1 NT_166523.1 Title: weak similarity to hypothetical DEAD-box RNA helicase SCH22A.10 - Streptomyces coelicolor; uncharacterized protein 196692 84591263 An07g01080 Aspergillus niger uncharacterized protein XP_059606106.1 195154 R 5061 CDS An07g01090 4981378 196726..198417 IV 1 NT_166523.1 Remark: expression of C. albicans MDR1-3 in S. cerevisiae confers resistance to several unrelated drugs.; Title: strong similarity to multidrug resistance protein MDR1-3 - Candida albicans; plasma membrane; See PMID 9745021; uncharacterized protein 198417 4981378 An07g01090 Aspergillus niger uncharacterized protein XP_001391199.1 196726 D 5061 CDS An07g01100 4981379 join(198864..199016,199079..199642) IV 1 NT_166523.1 Catalytic activity: glutathione S-transferase omega of S. scrofa catalyses the reaction RX + glutathione = HX + R-S-glutathione.; Localization: glutathione S-transferase omega of S. scrofa is cytosolic.; Similarity: the predicted A. niger protein shows similarity to glutathione S-transferase omega of S. scrofa,which belongs to the omega class [GSTO] of glutathione S-transferases.; Title: similarity to glutathione S-transferase omega - Sus scrofa; See PMID 11485575; uncharacterized protein 199642 4981379 An07g01100 Aspergillus niger uncharacterized protein XP_001391200.1 198864 D 5061 CDS An07g01110 4981380 complement(join(200069..200461,200705..200830,200877..201293,201342..201965)) IV 1 NT_166523.1 Catalytic activity: random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.; Title: similarity to hyaluronan synthase 3 Has3 -Mus musculus; See PMID 9083017; uncharacterized protein 201965 4981380 An07g01110 Aspergillus niger uncharacterized protein XP_059606107.1 200069 R 5061 CDS An07g01130 4981381 203367..204680 IV 1 NT_166523.1 Remark: Glomerella cingulata is also known as Glomerella rufomaculans-vaccinii[synonym] and Colletotrichum gloeosporioides[anamorph].; Remark: chip3 of Glomerella cingulata is induced by hard-surface contact of conidia of C. gloeosporioides.; Title: similarity to hypothetical hard surface induced protein chip3 - Glomerella cingulata; See PMID 10940006; uncharacterized protein 204680 4981381 An07g01130 Aspergillus niger uncharacterized protein XP_001391202.1 203367 D 5061 CDS An07g01140 4981382 join(204835..204985,205064..205101,205151..205328,205403..205519,205581..205843,205889..206824) IV 1 NT_166523.1 hypothetical protein 206824 4981382 An07g01140 Aspergillus niger hypothetical protein XP_059606108.1 204835 D 5061 CDS An07g01150 4981383 join(206940..207008,207094..207360,207404..207937,208002..209072) IV 1 NT_166523.1 Remark: acting on the CH-CH group of donors.; Similarity: protein shows also strong similarity to Phaffia rhodozyma carotenoid biosynthesis pathway enzyme PRcrtI from patent WO9723633-A1; Phaffia derived GAPDH and carotenoid synthesis genes are used in the recombinant production of therapeutically useful proteins e. g. carotenoids for use in food colouring.; Title: strong similarity to phytoene dehydrogenase PDH1 - Cercospora nicotianae; See PMID 8085820; uncharacterized protein 209072 4981383 An07g01150 Aspergillus niger uncharacterized protein XP_059606109.1 206940 D 5061 CDS An07g01160 4981384 complement(join(209438..210093,210140..210574,210628..210742)) IV 1 NT_166523.1 Function: CRH2 of S. cerevisiae expression did not vary during the mitotic cycle.; Function: two genes, CRH1 and CRH2 of S. cerevisiae,were shown to be involved in the development of cell wall architecture, since the alkali-soluble glucan fraction in a crh1Delta crh2Delta strain was almost twice the level in the wild-type.; Localization: Crh2 of S. cerevisiae was localized at the cell surface, particularly in chitin-rich areas.; Localization: Crh2p of S. cerevisiae was found to localize mainly at the bud neck throughout the whole budding cycle, in mating projections and zygotes, but not in ascospores.; Remark: alternate genename of UTR2 of S. cerevisiae is CHR2, the systematic gene name is YEL040w.; Title: strong similarity to cell wall protein Utr2 -Saccharomyces cerevisiae; cell wall; See PMID 10757808; uncharacterized protein 210742 4981384 An07g01160 Aspergillus niger uncharacterized protein XP_001391205.1 209438 R 5061 CDS An07g01170 84591264 join(210765..210879,210969..211023,211100..211359,211397..211535,212584..212699,212776..212874,213000..213109) IV 1 NT_166523.1 hypothetical protein 213109 84591264 An07g01170 Aspergillus niger hypothetical protein XP_059606110.1 210765 D 5061 CDS An07g01180 84591265 complement(join(213246..213330,213422..213534,213636..213644)) IV 1 NT_166523.1 hypothetical protein 213644 84591265 An07g01180 Aspergillus niger hypothetical protein XP_059606111.1 213246 R 5061 CDS An07g01190 84591266 join(213754..214652,214758..215022) IV 1 NT_166523.1 Title: weak similarity to hypothetical protein encoded by An07g03100 - Aspergillus niger; uncharacterized protein 215022 84591266 An07g01190 Aspergillus niger uncharacterized protein XP_059606112.1 213754 D 5061 CDS An07g01200 4981388 join(215063..215213,215276..215410,215478..215693,215748..216118,216207..216389) IV 1 NT_166523.1 Function: LovC of A. terreus is necessary for the correct processing of the growing polyketide chain and production of dihydromonacolin L during lovastatin biosynthesis.; Similarity: the ORF shows similarity to several oxidoreductases with different specificities and cellular functions.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994; See PMID 11457314; uncharacterized protein 216389 4981388 An07g01200 Aspergillus niger uncharacterized protein XP_001391209.1 215063 D 5061 CDS An07g01210 84591267 join(216724..216889,216973..217046,217195..217365,217484..217694,217772..217911,217983..218060) IV 1 NT_166523.1 hypothetical protein 218060 84591267 An07g01210 Aspergillus niger hypothetical protein XP_059606113.1 216724 D 5061 CDS An07g01220 4981390 join(218855..219070,219136..219212,219265..219316,219368..219563,219686..219757,219815..220327,220382..220542,220608..220967) IV 1 NT_166523.1 Function: might be involved in transport of antibiotics.; Function: possibly involved in modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis.; Function: shows pfam-domain common in sugar (and other) transporter.; Localization: shows several transmembrane domains.; Similarity: ORF10 of A. terreus is similar to efflux pumps and resistance proteins of different species.; Title: strong similarity to hypothetical protein encoded by ORF10 - Aspergillus terreus; uncharacterized protein 220967 4981390 An07g01220 Aspergillus niger uncharacterized protein XP_059606114.1 218855 D 5061 CDS An07g01230 84591268 complement(join(221289..221914,221936..221952,222017..222700,222835..222998)) IV 1 NT_166523.1 Function: suc uptake in D. carota was inhibited by protonophores, suggesting that Suc transport is linked to the proton electrochemical potential across the plasma membrane.; Similarity: shows higher similarity to probable sucrose carrier of S. pombe.; Title: similarity to source- and sink-specific sucrose/H+ symporters - Daucus carota; plasma membrane; See PMID 9847123; uncharacterized protein 222998 84591268 An07g01230 Aspergillus niger uncharacterized protein XP_059606115.1 221289 R 5061 CDS An07g01240 84591269 join(223301..223368,223465..223495,224001..224165,224670..224814,224943..225120,225199..225342,225937..225988,226066..226167) IV 1 NT_166523.1 Remark: ORF might be questionable.; hypothetical protein 226167 84591269 An07g01240 Aspergillus niger hypothetical protein XP_059606116.1 223301 D 5061 CDS An07g01250 4981393 complement(join(226905..227664,227714..228108,228160..228791,228847..228862,228916..230605,230658..231490)) IV 1 NT_166523.1 Remark: the transcription of atrA in mycelium of A. nidulans is strongly enhanced by treatment with several drugs, including antibiotics, azole fungicides and plant defense toxins.; Similarity: the protein shows also strong similarity to yeast transporter Pdr5p (PATENTPROT: AAB28182,patentno. WO200052144-A1).; Title: strong similarity to ATP-binding cassette multidrug transport protein atrA - Aspergillus nidulans; plasma membrane; See PMID 9180695; uncharacterized protein 231490 4981393 An07g01250 Aspergillus niger uncharacterized protein XP_001391214.1 226905 R 5061 CDS An07g01260 4981394 complement(join(232357..233086,233147..233387,233447..233910,234014..234155,234243..234345)) IV 1 NT_166523.1 Function: contains domain common in sugar transport proteins.; Similarity: shows strong similarity to several sugar transport proteins (including hypothetical and patented).; Title: strong similarity to hypothetical sugar transport-like protein Stl1 - Saccharomyces cerevisiae; plasma membrane; See PMID 8076821; uncharacterized protein 234345 4981394 An07g01260 Aspergillus niger uncharacterized protein XP_059606117.1 232357 R 5061 CDS An07g01270 4981395 complement(join(234989..237467,237823..237839)) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein EAK86332.1 - Ustilago maydis; uncharacterized protein 237839 4981395 An07g01270 Aspergillus niger uncharacterized protein XP_001391216.3 234989 R 5061 CDS An07g01280 4981396 join(238044..238141,238405..240353,240424..240662) IV 1 NT_166523.1 Remark: inactivation of the A. oryzae gene results in the inability to grow on gamma-amino-butyric acid (GABA) as a carbon and/or nitrogen source indicating that GABA utilization is amdR-dependent in A. oryzae, as it is in A. nidulans.; Title: similarity to transcription regulator AmdR -Aspergillus oryzae; See PMID 145202; uncharacterized protein 240662 4981396 An07g01280 Aspergillus niger uncharacterized protein XP_001391217.3 238044 D 5061 CDS An07g01290 4981397 complement(join(240737..241690,241755..241871,242021..242059)) IV 1 NT_166523.1 Catalytic activity: xylitol + NAD(+) <=> D-xylulose + NADH.; Remark: also acts as an L-erythrulose reductase.; Title: strong similarity to xylitol dehydrogenase xdh - Galactocandida mastotermitis; See PMID 9806889; See PMID 10661867; uncharacterized protein 242059 4981397 An07g01290 Aspergillus niger uncharacterized protein XP_059606118.1 240737 R 5061 CDS An07g01300 84591270 complement(join(242139..242271,242472..242665)) IV 1 NT_166523.1 hypothetical protein 242665 84591270 An07g01300 Aspergillus niger hypothetical protein XP_059606119.1 242139 R 5061 CDS An07g01310 4981399 join(242678..242894,242968..243665,243725..243965,244040..244470,244592..244753) IV 1 NT_166523.1 Function: high affinity glucose transporter.; Title: strong similarity to high affinity glucose transporter HGT1 - Kluyveromyces lactis; See PMID 8830679; uncharacterized protein 244753 4981399 An07g01310 Aspergillus niger uncharacterized protein XP_001391220.3 242678 D 5061 CDS An07g01320 4981400 complement(join(245151..245222,245284..245370,245439..245558)) IV 1 NT_166523.1 Function: the P. chrysogenum paf gene encodes an abundantly secreted protein with antifungal activity.; Title: strong similarity to antifungal protein precursor paf - Penicillium chrysogenum; uncharacterized protein 245558 4981400 An07g01320 Aspergillus niger uncharacterized protein XP_001391221.1 245151 R 5061 CDS An07g01340 4981401 247153..248193 IV 1 NT_166523.1 Title: weak similarity to phosphoenolpyruvate carboxylase - Escherichia coli; uncharacterized protein 248193 4981401 An07g01340 Aspergillus niger uncharacterized protein XP_001391222.1 247153 D 5061 CDS An07g01350 4981402 complement(join(249108..250259,250313..250350,250443..250494)) IV 1 NT_166523.1 Function: NahW of P. stutzeri is involved in naphthalene and salicylate metabolism.; Title: strong similarity to salicylate hydroxylase nahW - Pseudomonas stutzeri; See PMID 10197990; uncharacterized protein 250494 4981402 An07g01350 Aspergillus niger uncharacterized protein XP_059606120.1 249108 R 5061 CDS An07g01360 4981403 join(251242..251629,251819..252270,252338..252442,252475..252580,252779..253082,253137..253167,253215..253421) IV 1 NT_166523.1 Title: similarity to hypothetical protein CAD21381.1 - Neurospora crassa; uncharacterized protein 253421 4981403 An07g01360 Aspergillus niger uncharacterized protein XP_059606121.1 251242 D 5061 CDS An07g01380 4981405 complement(join(254879..255896,255943..256073,256115..256204,256297..257084,257129..257236,257381..257613,257674..257728,257783..257924)) IV 1 NT_166523.1 Function: CMR1, a novel transcriptional activator with Cys2His2 type zinc-finger and Zn(II)2Cys6 binuclear cluster motifs regulates transcription of melanin biosynthesis genes SCD1 and THR1 during mycelial melanization of C. lagenarium.; Remark: submitted (MAR-1999) to the EMBL by Kubo Y.; Title: strong similarity to hypothetical transcriptional activator CMR1 - Colletotrichum lagenarium; uncharacterized protein 257924 4981405 An07g01380 Aspergillus niger uncharacterized protein XP_059606122.1 254879 R 5061 CDS An07g01390 4981406 join(258886..258891,258999..259733) IV 1 NT_166523.1 Title: similarity to hypothetical conserved protein PA2839 - Pseudomonas aeruginosa; uncharacterized protein 259733 4981406 An07g01390 Aspergillus niger uncharacterized protein XP_001391226.3 258886 D 5061 CDS An07g01400 4981407 complement(join(259951..260288,260332..260447,260711..261153,261202..261603)) IV 1 NT_166523.1 Catalytic activity: an aldehyde + NAD(P)(+)+H(2)O <=> an acid + NAD(P)H; Title: similarity to aldehyde dehydrogenase ALDH3 -Rattus norvegicus; See PMID 9095201; See PMID 2713359; See PMID 2831537; uncharacterized protein 261603 4981407 An07g01400 Aspergillus niger uncharacterized protein XP_059606123.1 259951 R 5061 CDS An07g01410 4981408 join(261812..261865,261996..262301,262351..262431) IV 1 NT_166523.1 hypothetical protein 262431 4981408 An07g01410 Aspergillus niger hypothetical protein XP_001391228.3 261812 D 5061 CDS An07g01420 84591271 complement(join(262758..262799,262843..263085)) IV 1 NT_166523.1 Induction: binA gene expression induced by bafilomycin.; Title: strong similarity to hypothetical protein binA - Aspergillus nidulans; See PMID 10376827; uncharacterized protein 263085 84591271 An07g01420 Aspergillus niger uncharacterized protein XP_059606124.1 262758 R 5061 CDS An07g01430 4981410 complement(join(263689..263803,263853..264463,264491..264745,264794..264901,264980..265588)) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein Rv1215c - Mycobacterium tuberculosis; uncharacterized protein 265588 4981410 An07g01430 Aspergillus niger uncharacterized protein XP_059606125.1 263689 R 5061 CDS An07g01440 4981411 join(266019..266135,266205..266330,266412..266459,266512..267346,267397..268327,268477..268570) IV 1 NT_166523.1 Catalytic activity: salicylate + NADH + O2 = catechol + NAD+ + H2O + CO2.; Remark: the salicylate hydroxylase, a flavoprotein monooxygenase, catalyzes the decarboxylative hydroxylation of salicylate to form catechol.; Title: similarity to salicylate hydroxylase sal -Pseudomonas putida; See PMID 2916843; See PMID 8561793; See PMID 10920265; uncharacterized protein 268570 4981411 An07g01440 Aspergillus niger uncharacterized protein XP_059606126.1 266019 D 5061 CDS An07g01450 4981412 complement(join(268697..268861,268926..268953,269026..269269,269456..269548,269841..269904,270024..270147,270288..270345,270438..270506,270631..270685)) IV 1 NT_166523.1 hypothetical protein 270685 4981412 An07g01450 Aspergillus niger hypothetical protein XP_001391232.3 268697 R 5061 CDS An07g01460 84591272 join(270761..270850,270942..271119,271210..271314,271397..271534,271622..271837,271893..272020) IV 1 NT_166523.1 hypothetical protein 272020 84591272 An07g01460 Aspergillus niger hypothetical protein XP_059606127.1 270761 D 5061 CDS An07g01470 4981414 join(272436..272733,272788..273464) IV 1 NT_166523.1 Title: strong similarity to hypothetical v-snare binding protein SPAC56F8.08 - Schizosaccharomyces pombe; uncharacterized protein 273464 4981414 An07g01470 Aspergillus niger uncharacterized protein XP_001391234.3 272436 D 5061 CDS An07g01480 4981415 complement(join(273884..273984,274240..274343,274470..274536,274605..274757,274862..275056,275155..275248)) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein EAA58558.1 - Aspergillus nidulans; uncharacterized protein 275248 4981415 An07g01480 Aspergillus niger uncharacterized protein XP_059606128.1 273884 R 5061 CDS An07g01490 84591273 complement(join(275952..276080,276145..276249)) IV 1 NT_166523.1 hypothetical protein 276249 84591273 An07g01490 Aspergillus niger hypothetical protein XP_059606129.1 275952 R 5061 CDS An07g01500 84591274 complement(join(276663..276822,276881..276921,277114..277176,277489..277698)) IV 1 NT_166523.1 hypothetical protein 277698 84591274 An07g01500 Aspergillus niger hypothetical protein XP_059606130.1 276663 R 5061 CDS An07g01510 4981418 join(279514..280196,280262..280596,280662..280774) IV 1 NT_166523.1 Title: similarity to 2,4-dichlorophenoxyacetate monooxygenase tfdA - Alcaligenes eutrophus; See PMID 3036764; uncharacterized protein 280774 4981418 An07g01510 Aspergillus niger uncharacterized protein XP_001391238.1 279514 D 5061 CDS An07g01520 4981419 complement(join(282427..283035,283105..283602,283636..283734,283798..283886,283942..286407,286468..286759)) IV 1 NT_166523.1 Complex: Nup170p of S. cerevisiae binds to the amino-terminal domain of Nup1p. Nup170p is a part of the nuclear pore complex.; Function: Nup170p and Nup188p are involved in establishing the functional resting diameter of the NPC's central transport channel.; Remark: YBL079w is the systematic name of NUP170 and YER105c is the systematic name of NUP157.; Remark: a deletion strain of NUP170 (nup170 Delta::HIS3) has a Ctf- (chromosome transmission fidelity) phenotype similar to the s141 mutant (nup170-141) and also exhibits a kinetochore integrity defect.; Similarity: the predicted A. niger protein shows strong similarity to nucleoporin Nup170p and Nup157p of S. cerevisiae and related proteins from higher eucaryotes.; Title: strong similarity to nucleoporin Nup170 -Saccharomyces cerevisiae; nucleus; See PMID 8628268; See PMID 10831607; See PMID 11290711; uncharacterized protein 286759 4981419 An07g01520 Aspergillus niger uncharacterized protein XP_059606131.1 282427 R 5061 CDS An07g01530 4981420 join(287182..287324,287400..287805) IV 1 NT_166523.1 Title: weak similarity to hypothetical conserved protein VC0519 - Vibrio cholerae; uncharacterized protein 287805 4981420 An07g01530 Aspergillus niger uncharacterized protein XP_001391240.1 287182 D 5061 CDS An07g01540 4981421 complement(join(288194..288490,288540..288718,288794..288908,288996..289115)) IV 1 NT_166523.1 Remark: BLASTp searches with yeast hypothetical protein YMR200w/Rot1p and Dna2p demonstrate, that Rot1p and Dna2p are not related as opposed to results described by Fiorentino and Crabtree (Mol Biol Cell 1997; 8(12):2519-37).; Remark: null mutant is inviable; rot1 mutations can suppress tor2 mutations; synthetically lethal with rot2.; Remark: reversal of tor2 lethality.; Similarity: the predicted A. niger protein shows strong similarity to yeast hypothetical protein YMR200w/Rot1p.; Title: strong similarity to hypothetical protein YMR200w - Saccharomyces cerevisiae; See PMID 9398673; See PMID 9545237; uncharacterized protein 289115 4981421 An07g01540 Aspergillus niger uncharacterized protein XP_001391241.3 288194 R 5061 CDS An07g01550 4981422 join(289449..289542,289603..290028,290112..290296) IV 1 NT_166523.1 Catalytic activity: ATP + 5-formyltetrahydrofolate = ADP + orthophosphate + 5,10-methenyltetrahydrofolate.; Remark: This enzyme is involved in the regulation of the folate-dependent reactions of amino acid, purine and pyrimidine synthesis through modulation of intracellular 5-formyltetrahydrofolate polyglutamates.; Remark: the enzyme catalyses the obligatory initial metabolic step in the intracellular conversion of 5-formyltetrahydrofolate to other reduced folates.; Title: similarity to 5-formyltetrahydrofolate cyclo-ligase MTHFS - Homo sapiens; See PMID 8522195; uncharacterized protein 290296 4981422 An07g01550 Aspergillus niger uncharacterized protein XP_059606132.1 289449 D 5061 CDS An07g01560 4981423 complement(join(290502..290554,290627..290717,290774..290917)) IV 1 NT_166523.1 Remark: the human small nuclear ribonucleoprotein E protein is an integral component of several small nuclear ribonucleoprotein complexes involved in RNA processing reactions.; Remark: the snRNP E protein is one of four 'core' proteins associated with the snRNAs of the U family (U1, U2, U4, U5, and U6).; Title: strong similarity to small nuclear ribonucleoprotein E - Homo sapiens; nucleus; See PMID 2972723; See PMID 1835977; uncharacterized protein 290917 4981423 An07g01560 Aspergillus niger uncharacterized protein XP_001391243.1 290502 R 5061 CDS An07g01570 84591275 complement(join(290951..291175,291293..291340)) IV 1 NT_166523.1 hypothetical protein 291340 84591275 An07g01570 Aspergillus niger hypothetical protein XP_059606133.1 290951 R 5061 CDS An07g01580 4981425 join(291384..291515,291613..291705,291765..292037,292148..292244,292305..293585,293638..294063,294134..294664,294722..294810) IV 1 NT_166523.1 Remark: Mtr10p binds peptide repeat-containing nucleoporins and Ran.; Remark: Mtr10p is shown to be responsible for the nuclear import of the shuttling mRNA-binding protein Npl3p.; Title: strong similarity to nuclear import protein Mtr10 - Saccharomyces cerevisiae; See PMID 9412460; uncharacterized protein 294810 4981425 An07g01580 Aspergillus niger uncharacterized protein XP_059606134.1 291384 D 5061 CDS An07g01590 84591276 complement(join(295094..295187,295257..295271,295365..295486)) IV 1 NT_166523.1 hypothetical protein 295486 84591276 An07g01590 Aspergillus niger hypothetical protein XP_059606135.1 295094 R 5061 CDS An07g01600 84591277 join(295943..296046,296148..296261,296550..296639,296712..296786,296877..296880,296981..297097,297234..297392) IV 1 NT_166523.1 hypothetical protein 297392 84591277 An07g01600 Aspergillus niger hypothetical protein XP_059606136.1 295943 D 5061 CDS An07g01610 84591278 complement(join(297421..297732,297772..297849,297924..298163,298366..298414,298567..298654,299002..299232,299274..299280)) IV 1 NT_166523.1 hypothetical protein 299280 84591278 An07g01610 Aspergillus niger hypothetical protein XP_059606137.1 297421 R 5061 CDS An07g01620 4981429 join(299787..300027,300086..300866,301230..302925) IV 1 NT_166523.1 Remark: the gene contains two C2H2 zinc fingers, a nuclear localization sequence and two transcriptional activation domains. mutations in the amdA gene lead to elevated expression of the gene encoding acetamidase, amdS. these mutations also cause constitutive expression of the acetate-inducible gene, aciA.; Similarity: the predicted A. niger protein shows similarity to the DNA-binding protein amdA from A. nidulans and strong similarity to fungal hypothetical zinc finger proteins.; Title: similarity to zinc-finger transcription factor amdA - Aspergillus nidulans; See PMID 7596297; See PMID 9126617; uncharacterized protein 302925 4981429 An07g01620 Aspergillus niger uncharacterized protein XP_059606138.1 299787 D 5061 CDS An07g01630 84591279 complement(join(303340..303543,303711..303836)) IV 1 NT_166523.1 hypothetical protein 303836 84591279 An07g01630 Aspergillus niger hypothetical protein XP_059606139.1 303340 R 5061 CDS An07g01640 4981431 join(303940..304108,304165..304305,304357..304449,304511..304539) IV 1 NT_166523.1 Remark: among the enzymes to be stimulated by the calmodulin Ca(++) complex are protein kinases and phosphatases.; Remark: calmodulin has four functional calcium-binding sites and shows similarity to other EF-hand calcium binding proteins.; Remark: calmodulin mediates the control of a large number of enzymes by Ca(++).; Title: strong similarity to calmodulin 6 CaM6 -Arabidopsis thaliana; See PMID 8507825; uncharacterized protein 304539 4981431 An07g01640 Aspergillus niger uncharacterized protein XP_001391251.3 303940 D 5061 CDS An07g01650 4981432 complement(join(304777..304798,304892..305469)) IV 1 NT_166523.1 Similarity: similarity of the predicted A. niger protein to various protein sequences is due to low complexity sequences.; hypothetical protein 305469 4981432 An07g01650 Aspergillus niger hypothetical protein XP_001391252.3 304777 R 5061 CDS An07g01660 84591280 join(306052..306114,306209..306286,306372..306458,306499..306568,306646..306919,307318..307409,307492..307757) IV 1 NT_166523.1 Title: weak similarity to hypothetical host-specific AK-toxin Akt2 like protein CAB91703.2 - Neurospora crassa; uncharacterized protein 307757 84591280 An07g01660 Aspergillus niger uncharacterized protein XP_059606140.1 306052 D 5061 CDS An07g01670 4981434 join(308048..308097,308164..309025) IV 1 NT_166523.1 Remark: the Japanese pear pathotype of A. alternata causes black spot of Japanese pear by producing a host-specific toxin known as AK-toxin.; Remark: the essential roles of AKT1 and AKT2 in both AK-toxin production and pathogenicity were confirmed by transformation-mediated gene disruption experiments. AKT2 encodes a protein of unknown function.; Title: similarity to protein required for biosynthesis of the host-specific AK-toxin Akt2 -Alternaria alternata; See PMID 10432635; See PMID 10975654; uncharacterized protein 309025 4981434 An07g01670 Aspergillus niger uncharacterized protein XP_001391254.3 308048 D 5061 CDS An07g01680 4981435 join(309424..309899,309937..310468,310516..311703) IV 1 NT_166523.1 Similarity: shows similarity to several known and hypothetical transcriptional activators, the similarity is restricted to the zinc finger domain.; Title: similarity to hypothetical transcription activator CAB59617.1 - Schizosaccharomyces pombe; uncharacterized protein 311703 4981435 An07g01680 Aspergillus niger uncharacterized protein XP_059606141.1 309424 D 5061 CDS An07g01690 4981436 join(312814..312899,312968..314546) IV 1 NT_166523.1 Title: weak similarity to hypothetical protein CAC28841.2 - Neurospora crassa; uncharacterized protein 314546 4981436 An07g01690 Aspergillus niger uncharacterized protein XP_001391256.1 312814 D 5061 CDS An07g01700 4981437 complement(join(314686..314965,315019..315214,315292..315889,315937..316431,316629..316817)) IV 1 NT_166523.1 Title: similarity to hypothetical protein CAD21260.1 - Neurospora crassa; uncharacterized protein 316817 4981437 An07g01700 Aspergillus niger uncharacterized protein XP_059606142.1 314686 R 5061 CDS An07g01710 4981438 complement(join(316861..317604,317661..317945,318001..318042)) IV 1 NT_166523.1 Catalytic activity: myo-inositol 2-dehydrogenase (iolG) from B. subtilis catalyses the reaction myo-inositol + NAD(+)<=> 2,4,6/3,5-pentahydroxycyclohexanone + NADH.; Function: myo-inositol 2-dehydrogenase (iolG) from B. subtilis catalyses the first step in inositol catabolism to utilize myo-inositol as sole carbon/energy source.; Similarity: the ORF shows similarity to several unspecified NADH-dependent dyhydrogenases from bacteria.; Title: strong similarity to myo-inositol 2-dehydrogenase iolG - Bacillus subtilis; See PMID 9226270; See PMID 112095; uncharacterized protein 318042 4981438 An07g01710 Aspergillus niger uncharacterized protein XP_001391258.1 316861 R 5061 CDS An07g01720 84591281 join(318674..318712,318816..320219) IV 1 NT_166523.1 Title: weak similarity to regulator protein Uga3 -Saccharomyces cerevisiae; uncharacterized protein 320219 84591281 An07g01720 Aspergillus niger uncharacterized protein XP_059606143.1 318674 D 5061 CDS An07g01730 4981440 complement(join(320297..320522,320581..320823,320858..321285)) IV 1 NT_166523.1 Similarity: the predicted A. niger protein shows strong similarity to the hypothetical protein YJR154w of S. cerevisiae and to a hypothetical protein derived from P. aeruginosa pathogenicity island (PAGI-1).; Title: strong similarity to hypothetical protein YJR154w - Saccharomyces cerevisiae; uncharacterized protein 321285 4981440 An07g01730 Aspergillus niger uncharacterized protein XP_059606144.1 320297 R 5061 CDS An07g01740 4981441 complement(join(321859..322404,322565..322688,322746..322825,322883..323026,323093..323323)) IV 1 NT_166523.1 Remark: the patent does not provide further information about the function of the protein.; Title: weak similarity to polypeptide sequence SEQ ID NO:3328 from patent WO200058473-A2 - Homo sapiens; uncharacterized protein 323323 4981441 An07g01740 Aspergillus niger uncharacterized protein XP_059606145.1 321859 R 5061 CDS An07g01750 4981442 complement(join(324774..325359,325432..325781)) IV 1 NT_166523.1 Title: weak similarity to hypothetical protein B2O8.260 - Neurospora crassa; uncharacterized protein 325781 4981442 An07g01750 Aspergillus niger uncharacterized protein XP_059606146.1 324774 R 5061 CDS An07g01760 84591282 complement(join(326026..326091,326847..326934,327007..327137,327227..327292)) IV 1 NT_166523.1 Title: questionable ORF; uncharacterized protein 327292 84591282 An07g01760 Aspergillus niger uncharacterized protein XP_059606147.1 326026 R 5061 CDS An07g01770 84591283 complement(join(327634..327917,328066..328510,328785..328874,328956..329056,329104..329230,329446..329499)) IV 1 NT_166523.1 hypothetical protein 329499 84591283 An07g01770 Aspergillus niger hypothetical protein XP_059606148.1 327634 R 5061 CDS An07g01780 4981445 join(329516..329693,329799..330373) IV 1 NT_166523.1 Title: weak similarity to hypothetical galactosyltransferase spdbp - Schizosaccharomyces pombe; uncharacterized protein 330373 4981445 An07g01780 Aspergillus niger uncharacterized protein XP_059606149.1 329516 D 5061 CDS An07g01790 84591284 join(331492..331676,331769..331880) IV 1 NT_166523.1 hypothetical protein 331880 84591284 An07g01790 Aspergillus niger hypothetical protein XP_059606150.1 331492 D 5061 CDS An07g01800 84591285 complement(join(332100..332451,332548..332589,332668..332817,332901..333058)) IV 1 NT_166523.1 hypothetical protein 333058 84591285 An07g01800 Aspergillus niger hypothetical protein XP_059606151.1 332100 R 5061 CDS An07g01810 4981448 join(<334526..334973,335081..>335239) IV 1 NT_166523.1 hypothetical protein 335239 4981448 An07g01810 Aspergillus niger hypothetical protein XP_001391268.3 334526 D 5061 CDS An07g01820 84591286 complement(join(<336495..336530,336612..336692,336828..336956)) IV 1 NT_166523.1 Remark: truncated ORF due to end of contig.; Title: weak similarity to stationary phase induced protein Spi1 - Saccharomyces cerevisiae [truncated ORF]; See PMID 10641036; See PMID 11136466; uncharacterized protein 336956 84591286 An07g01820 Aspergillus niger uncharacterized protein XP_059605333.1 336495 R 5061 CDS An07g01830 4981450 join(337639..337758,337817..338497) IV 1 NT_166523.1 Catalytic activity: scytalone + NADP(+) <-> 1,3,6,8-tetrahydroxynaphthalene + NADPH.; EC:1.1.1.256; Remark: tetrahydroxynaphthalene reductase is involved with EC 4. 2. 1. 94 in the biosynthesis of melanin in pathogenic fungi.; Title: strong similarity to 1,3,6,8-tetrahydroxynaphthalene reductase arp2 - Aspergillus fumigatus; See PMID 10515939; See PMID 8293526; uncharacterized protein 338497 4981450 An07g01830 Aspergillus niger uncharacterized protein XP_001391270.1 337639 D 5061 CDS An07g01840 84591287 join(338551..338579,338661..338772,338966..339070,339179..339337) IV 1 NT_166523.1 hypothetical protein 339337 84591287 An07g01840 Aspergillus niger hypothetical protein XP_059605334.1 338551 D 5061 CDS An07g01850 4981452 join(339631..340859,340917..344508) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein CAD21096.1 - Neurospora crassa; uncharacterized protein 344508 4981452 An07g01850 Aspergillus niger uncharacterized protein XP_001391272.1 339631 D 5061 CDS An07g01860 84591288 complement(join(344516..344614,344742..344881,345000..345087,345426..345572)) IV 1 NT_166523.1 Catalytic activity: (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c.; Remark: the systematic name for CYB2 of S. cerevisiae is YML054C.; Title: weak similarity to L-lactate dehydrogenase precursor Cyb2 - Saccharomyces cerevisiae; See PMID 3004948; uncharacterized protein 345572 84591288 An07g01860 Aspergillus niger uncharacterized protein XP_059605335.1 344516 R 5061 CDS An07g01870 4981454 complement(join(346228..347142,347208..347495,347576..348226)) IV 1 NT_166523.1 Catalytic activity: phenol + NADPH + O2 = catechol + NADP+ + H2O.; Remark: FAD is used as cofactor of phenol hydroxylase in Trichosporon cutaneum.; Remark: alternate name = phenol 2-monooxygenase.; Remark: phenol hydroxylases are involved in degradation of phenylalanine, toluene and gamma-hexachlorocyclohexane.; Title: strong similarity to phenol hydroxylase -Trichosporon cutaneum; See PMID 9634698; See PMID 1429434; uncharacterized protein 348226 4981454 An07g01870 Aspergillus niger uncharacterized protein XP_001391274.1 346228 R 5061 CDS An07g01880 84591289 complement(join(348250..348381,348450..348497)) IV 1 NT_166523.1 hypothetical protein 348497 84591289 An07g01880 Aspergillus niger hypothetical protein XP_059605336.1 348250 R 5061 CDS An07g01890 84591290 join(348836..349060,349240..349296) IV 1 NT_166523.1 hypothetical protein 349296 84591290 An07g01890 Aspergillus niger hypothetical protein XP_059605337.1 348836 D 5061 CDS An07g01900 4981457 join(349500..350179,350257..350421,350488..350872) IV 1 NT_166523.1 Protein sequence is in conflict with the conceptual translation; Catalytic activity: 3-(4-hydroxyphenyl)pyruvate + O2 = homogentisate + CO2.; Remark: alternate name = TcrP (T-cell reactive protein).; Title: strong similarity to 4-hydroxyphenylpyruvate-dioxygenase tcrP - Coccidioides immitis [putative sequencing error]; putative sequencing error; See PMID 7642122; uncharacterized protein 350872 4981457 An07g01900 Aspergillus niger uncharacterized protein XP_001391277.3 349500 D 5061 CDS An07g01910 4981458 join(351252..352560,352624..352724) IV 1 NT_166523.1 Protein sequence is in conflict with the conceptual translation; Title: strong similarity to hypothetical protein EAA58547.1 - Aspergillus nidulans [putative sequencing error]; putative sequencing error; uncharacterized protein 352724 4981458 An07g01910 Aspergillus niger uncharacterized protein XP_001391278.3 351252 D 5061 CDS An07g01930 4981460 join(354191..354606,354648..354754,354803..354970,355025..355049,355127..355714,355769..355958,356016..356868,357189..357517,357953..358675) IV 1 NT_166523.1 Remark: the ankyrin gene from Mus musculus undergoes alternative splicing, resulting in 4 different splice variants.; Title: similarity to ankyrin 3 (splice form 3) - Mus musculus; uncharacterized protein 358675 4981460 An07g01930 Aspergillus niger uncharacterized protein XP_059605338.1 354191 D 5061 CDS An07g01940 4981461 complement(join(359047..359093,359151..359324,359399..360256,360320..360565,360633..360723)) IV 1 NT_166523.1 Remark: putative frameshift due to possible sequencing error at position 9631.; Title: similarity to hypothetical amine transporter SPCC18.02 - Schizosaccharomyces pombe [putative frameshift]; uncharacterized protein 360723 4981461 An07g01940 Aspergillus niger uncharacterized protein XP_001391280.1 359047 R 5061 CDS An07g01950 4981462 complement(join(361379..362868,362914..363080,363130..363221)) IV 1 NT_166523.1 Title: strong similarity to purine permease with broad specificity uapC - Aspergillus nidulans; uncharacterized protein 363221 4981462 An07g01950 Aspergillus niger uncharacterized protein XP_001391281.1 361379 R 5061 CDS An07g01960 4981463 join(368267..368507,368572..369701) IV 1 NT_166523.1 Title: strong similarity to stearoyl-CoA desaturase P-ole1 - Pichia angusta; uncharacterized protein 369701 4981463 An07g01960 Aspergillus niger uncharacterized protein XP_001391282.1 368267 D 5061 CDS An07g01970 4981464 join(370624..371940,371988..372628,372683..372875) IV 1 NT_166523.1 Title: strong similarity to cytoplasmic metalloproteinase mepB - Aspergillus fumigatus; cytoplasm; uncharacterized protein 372875 4981464 An07g01970 Aspergillus niger uncharacterized protein XP_001391283.1 370624 D 5061 CDS An07g01980 84591291 complement(join(377407..377447,377802..378069)) IV 1 NT_166523.1 Title: questionable ORF; uncharacterized protein 378069 84591291 An07g01980 Aspergillus niger uncharacterized protein XP_059605339.1 377407 R 5061 CDS An07g01990 4981466 join(379163..379205,379266..379527,379621..379709,379755..380353,380425..380940) IV 1 NT_166523.1 Function: rhp55p from S. pombe is involved in double-strand break repair.; Remark: the S. pombe rhp55Delta mutant Is highly sensitive to DNA damage.; Title: similarity to DNA repair protein rhp55p -Schizosaccharomyces pombe; See PMID 10430583; See PMID 11560889; uncharacterized protein 380940 4981466 An07g01990 Aspergillus niger uncharacterized protein XP_059605340.1 379163 D 5061 CDS An07g02000 4981467 complement(381132..382154) IV 1 NT_166523.1 Title: similarity to hypothetical protein encoded by An18g03630 - Aspergillus niger; uncharacterized protein 382154 4981467 An07g02000 Aspergillus niger uncharacterized protein XP_001391286.1 381132 R 5061 CDS An07g02010 4981468 complement(join(383417..383535,383587..384192,384261..384311,384367..384386,384438..384481)) IV 1 NT_166523.1 Complex: Pre8 from S. cerevisiae is one of the subunits of the proteasome.; Function: Pre8 from S. cerevisiae is essential for growth.; Function: Pre8 from S. cerevisiae takes part in the ubiquitin dependend protein degradation.; Localization: yeast proteasomes are mainly localized in the nuclear envelope-ER network.; Remark: the synonym for PRE8 from S. cerevisiae is YML092c.; Title: strong similarity to proteasome 20S subunit Pre8 - Saccharomyces cerevisiae; See PMID 9575337; See PMID 10744762; uncharacterized protein 384481 4981468 An07g02010 Aspergillus niger uncharacterized protein XP_001391287.1 383417 R 5061 CDS An07g02020 4981469 join(384900..385724,385783..385929) IV 1 NT_166523.1 Title: similarity to hypothetical protein CAB91761.2 - Neurospora crassa; uncharacterized protein 385929 4981469 An07g02020 Aspergillus niger uncharacterized protein XP_001391288.1 384900 D 5061 CDS An07g02030 84591292 complement(join(386825..387079,387163..387210)) IV 1 NT_166523.1 hypothetical protein 387210 84591292 An07g02030 Aspergillus niger hypothetical protein XP_059605341.1 386825 R 5061 CDS An07g02040 4981471 join(387576..388600,388676..389306) IV 1 NT_166523.1 Title: weak similarity to hypothetical protein Tid3 - Saccharomyces cerevisiae; uncharacterized protein 389306 4981471 An07g02040 Aspergillus niger uncharacterized protein XP_001391290.1 387576 D 5061 CDS An07g02050 4981472 complement(join(389708..390434,390499..390800)) IV 1 NT_166523.1 Catalytic activity: 2,3-dihydroxybenzoate <=> catechol + CO(2).; Function: 2,3-Dihydroxybenzoic acid decarboxylase is the last enzyme in the fungal metabolism of indole to catechol and catalyzes the non-oxidative decarboxylation of 2,3-dihydroxybenzoic acid to catechol.; Gene-ID: dhbD; See PMID 7601088; 2,3-dihydroxybenzoic acid decarboxylase dhbD-Aspergillus niger 390800 dhbD 4981472 dhbD Aspergillus niger 2,3-dihydroxybenzoic acid decarboxylase dhbD-Aspergillus niger XP_001391291.1 389708 R 5061 CDS An07g02060 4981473 join(392575..393007,393078..393842,393944..394683) IV 1 NT_166523.1 Title: similarity to myo-inositol transporter 2 -Schizosaccharomyces pombe; plasma membrane; See PMID 9560432; uncharacterized protein 394683 4981473 An07g02060 Aspergillus niger uncharacterized protein XP_059605342.1 392575 D 5061 CDS An07g02070 4981474 complement(join(396074..396105,396371..396794)) IV 1 NT_166523.1 Title: weak similarity to hypothetical protein SC8D9.09 SC8D9.09 - Streptomyces coelicolor; uncharacterized protein 396794 4981474 An07g02070 Aspergillus niger uncharacterized protein XP_001391293.3 396074 R 5061 CDS An07g02080 4981475 398209..399399 IV 1 NT_166523.1 Function: The mitochondrial outer membrane enzyme kynurenine 3-hydroxylase (K3H) is an NADPH-dependent flavin mono-oxygenase involved in the tryptophan pathway, where it catalyzes the hydroxylation of kynurenine.; Title: similarity to kynurenine3-hydroxylase hK3OH-2 - Homo sapiens; localisation:mitochondrion; See PMID 10672018; See PMID 6468727; uncharacterized protein 399399 4981475 An07g02080 Aspergillus niger uncharacterized protein XP_001391294.3 398209 D 5061 CDS An07g02090 4981476 join(400276..400439,400516..400556,400655..400735,400823..401102,401160..401919) IV 1 NT_166523.1 Title: weak similarity to hypothetical chloroplast RNA-binding protein At2g35410 - Arabidopsis thaliana; uncharacterized protein 401919 4981476 An07g02090 Aspergillus niger uncharacterized protein XP_059605343.1 400276 D 5061 CDS An07g02100 4981477 join(403468..403521,403808..403880,403935..404521,404569..405213) IV 1 NT_166523.1 Catalytic activity: fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + orthophosphate.; Function: The S. cerevisiae fructose-2,6-bisphosphate 2-phosphatase FBP26 is a bifunctional enzyme with catalytic activities of EC 2. 7. 1. 105 and predominantely EC 3. 1. 3. 46.; Title: strong similarity to fructose-2,6-bisphosphate 2-phosphatase Fbp26 - Saccharomyces cerevisiae; cytoplasm; See PMID 9032446; See PMID 1322693; uncharacterized protein 405213 4981477 An07g02100 Aspergillus niger uncharacterized protein XP_001391296.1 403468 D 5061 CDS An07g02110 4981478 join(406153..408730,408778..408886,408932..409417,409466..409508) IV 1 NT_166523.1 EC:3.4.16.1; Function: CPY releases a C-terminal amino acid with a broad specificity.; Function: the S. cerevisiae homolog CPY bears the major proteolytic activity in the yeast vacuole. it is synthesized as a precursor that is processed upon entry into the vacuolar lumen. mature CPY processes CPY precursor as well as other vacuolar protease precursors.; Remark: a deletion of CPY leads to complete loss of vacuolar proteolytic activity within days of growth due to slowly decreasing processing of other vacuolar protease precursors.; Remark: similarity corresponds only to the C-terminus.; Remark: the CPY vacuolar targeting signal is defined by four propeptide amino acids.; Similarity: CPY belongs to serine carboxypeptidase family S10.; Title: similarity to vacuolar carboxypeptidase Y Cpy - Saccharomyces cerevisiae; vacuole; See PMID 9111041; uncharacterized protein 409508 4981478 An07g02110 Aspergillus niger uncharacterized protein XP_001391297.1 406153 D 5061 CDS An07g02120 4981479 complement(409801..410091) IV 1 NT_166523.1 Title: weak similarity to hypothetical protein YJL184w - Saccharomyces cerevisiae; uncharacterized protein 410091 4981479 An07g02120 Aspergillus niger uncharacterized protein XP_001391298.1 409801 R 5061 CDS An07g02130 4981480 410454..412997 IV 1 NT_166523.1 Title: strong similarity to hypothetical protein CAD21228.1 - Neurospora crassa; uncharacterized protein 412997 4981480 An07g02130 Aspergillus niger uncharacterized protein XP_001391299.1 410454 D 5061 CDS An07g02140 84591293 complement(join(414076..414201,414262..414419,414581..414622,414655..414835)) IV 1 NT_166523.1 Title: weak similarity to hypothetical endogenous retrovirus W envelope protein - Homo sapiens; uncharacterized protein 414835 84591293 An07g02140 Aspergillus niger uncharacterized protein XP_059600857.1 414076 R 5061 CDS An07g02150 4981482 join(415473..416457,416519..418419,418482..418599,418865..418915,419151..419308) IV 1 NT_166523.1 Title: similarity to hypothetical AAA family ATPase Cj0377 - Campylobacter jejuni; uncharacterized protein 419308 4981482 An07g02150 Aspergillus niger uncharacterized protein XP_001391301.3 415473 D 5061 CDS An07g02160 4981483 complement(join(420085..420678,420740..420834,420900..421049,421131..421248,421323..421388)) IV 1 NT_166523.1 Catalytic activity: (S)-malate + NAD(+) = oxaloacetate + NADH.; Title: strong similarity to mitochondrial malate dehydrogenase Mdh1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 3072021; See PMID 3312168; See PMID 1447211; uncharacterized protein 421388 4981483 An07g02160 Aspergillus niger uncharacterized protein XP_001391302.1 420085 R 5061 CDS An07g02170 4981484 complement(join(422138..422584,422654..422877,422975..423038)) IV 1 NT_166523.1 Function: Bos1 of S. cerevisiae appears to be a membrane protein that functions in conjunction with Bet1 and Sec22 to facilitate the transport of proteins at a step subsequent to translocation into the ER but before entry into the Golgi apparatus.; Title: similarity to transport protein Bos1 -Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 1396561; See PMID 2007627; See PMID 2192256; uncharacterized protein 423038 4981484 An07g02170 Aspergillus niger uncharacterized protein XP_059600858.1 422138 R 5061 CDS An07g02180 4981485 complement(join(423757..423790,423856..424269,424414..424505,424973..425018,425165..426222,426291..426514,426580..426629,426705..426814)) IV 1 NT_166523.1 Catalytic activity: acetyl-CoA + dihydrolipoamide <=> CoA + S-acetyldihydrolipoamide.; Function: the s. cerevisiae dihydrolipoamide acetyltransferase is a component (E2) of the mitochondrial pyruvate dehydrogenase complex.; Remark: the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-coa & co(2).; Remark: the pyruvate dehydrogenase complex contains multiple copies of three enzymatic components: pyruvate dehydrogenase (e1), dihydrolipoamide acetyltransferase (e2) & lipoamide dehydrogenase (e3).; Title: strong similarity to dihydrolipoamide acetyltransferase Lat1 - Saccharomyces cerevisiae; localisation:mitochondrion; uncharacterized protein 426814 4981485 An07g02180 Aspergillus niger uncharacterized protein XP_059600859.1 423757 R 5061 CDS An07g02190 4981486 join(427225..428301,428455..428994,429046..429271,429319..432454,432599..433001) IV 1 NT_166523.1 Function: the Sec7 protein of S. cerevisiae may function as a peripheral membrane protein that cycles between a soluble, cytosolic pool and a sedimentable,membrane-associated complex for its essential role in vesicular traffic through the Golgi apparatus.; Title: strong similarity to protein Sec7 -Saccharomyces cerevisiae; cytoplasm; See PMID 3042778; See PMID 1986005; uncharacterized protein 433001 4981486 An07g02190 Aspergillus niger uncharacterized protein XP_059600860.1 427225 D 5061 CDS An07g02200 4981487 complement(join(433784..433913,433980..434461,434542..434637)) IV 1 NT_166523.1 Catalytic activity: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L- homocysteine + sirohydrochlorin.; Title: similarity to siroheme synthase cysG -Escherichia coli; See PMID 2407558; See PMID 2200672; uncharacterized protein 434637 4981487 An07g02200 Aspergillus niger uncharacterized protein XP_001391306.1 433784 R 5061 CDS An07g02210 4981488 join(435000..435258,435323..435332,435385..435505,435596..436711) IV 1 NT_166523.1 Catalytic activity: ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate.; Function: the S. cerevisiae PRPS1 is a rate-limiting enzyme in the biosynthesis of nucleotides, histidine, and tryptophan. disruption of this gene causes the most dramatic decrease in cell growth rate and enzyme activity.; Remark: disruption of the other ribose-phosphate pyrophosphokinases in S. cerevisiae (PRS2 or PRS4) has little measurable effect.; Remark: the S. cerevisiae genome contains a family of five ribose-phosphate pyrophosphokinase genes,PRS1-PRS5.; Similarity: the predicted A. niger protein shows strong similarity to ribose-phosphate pyrophosphokinase 1 (PRPS1) from S. cerevisiae and from many other organisms.; Title: strong similarity to ribose-phosphate pyrophosphokinase Prps1 - Saccharomyces cerevisiae; See PMID 7992503; See PMID 8007970; See PMID 9108276; See PMID 11101685; uncharacterized protein 436711 4981488 An07g02210 Aspergillus niger uncharacterized protein XP_001391307.3 435000 D 5061 CDS An07g02220 84591294 complement(join(437490..437553,437723..437772,437859..437981)) IV 1 NT_166523.1 hypothetical protein 437981 84591294 An07g02220 Aspergillus niger hypothetical protein XP_059600861.1 437490 R 5061 CDS An07g02230 84591295 join(441752..441912,441981..442025,442110..442209) IV 1 NT_166523.1 hypothetical protein 442209 84591295 An07g02230 Aspergillus niger hypothetical protein XP_059600862.1 441752 D 5061 CDS An07g02240 4981491 complement(join(443477..443500,443587..443649,443757..443770,443815..443930,443975..444032,444225..444265,444640..445211,445264..445430,445773..446033,446082..446223,446302..446703,446752..446894,446950..447351,447406..447454)) IV 1 NT_166523.1 Alternative name: SPO14; Catalytic activity: a phosphatidylcholine + H(2)O = choline + a phosphatidate.; Function: the PLD1 protein of S. pombe is required for meiosis and spore formation and seems to be involved in the coordinate induction of late meiotic events.; Remark: activity of S. pombe Pld1 is dependent of phosphatidylinositol 4,5-bisphosphate.; Remark: activity of S. pombe Pld1 is induced under sporulation conditions and seems to be necessary to complete the meiotic cycle, but not for vegetative cell growth.; Similarity: similarities corresponds only to the C-terminus, Blastx results showed no similarities for N-terminus.; Title: strong similarity to phospholipase Pld1 -Saccharomyces cerevisiae; See PMID 8576189; See PMID 8618862; See PMID 1582554; uncharacterized protein 447454 4981491 An07g02240 Aspergillus niger uncharacterized protein XP_059600863.1 443477 R 5061 CDS An07g02250 4981492 join(448405..448519,448626..448740,448793..448866,448914..449046,449094..449184,449236..449499,449561..449977) IV 1 NT_166523.1 Title: strong similarity to hypothetical DNA methylase SPAC27D7.08c - Schizosaccharomyces pombe; uncharacterized protein 449977 4981492 An07g02250 Aspergillus niger uncharacterized protein XP_059600864.1 448405 D 5061 CDS An07g02260 84591296 complement(join(450196..450858,450860..450936,451075..>451720)) IV 1 NT_166523.1 Protein sequence is in conflict with the conceptual translation; Remark: 5'-truncated ORF due to end of contig.; Remark: putative frameshift due to possible sequencing error at position 864.; Similarity: similarity to S. pombe gene SPAC4F10. 21 probably extends over the contig border.; Title: strong similarity to hypothetical protein SPAC4F10.21 - Schizosaccharomyces pombe [truncated ORF] [putative frameshift]; putative frameshift; uncharacterized protein 451720 84591296 An07g02260 Aspergillus niger uncharacterized protein XP_059600865.1 450196 R 5061 CDS An07g02270 4981494 complement(join(<451826..453043,453116..453418)) IV 1 NT_166523.1 Function: mbp1 binds to mcb elements (mlu1 cell cycle box) found in the promoter of most dna synthesis genes.; Function: the transcriptional activation by mbp1 has an important role in the transition from G1 to S phase.; Remark: C-terminally truncated ORF due to contig border.; Remark: it is supposed that the predicted ORF is 300 amino acids shorter at its C-terminus due to the end of the contig.; Similarity: the predicted ORF shows similarity with mbp1 of several spezies, but is 100 amino acids longer at its N-terminal end.; Title: strong similarity to transcription factor Mbp1 - Saccharomyces cerevisiae [truncated ORF]; nucleus; See PMID 8372350; uncharacterized protein 453418 4981494 An07g02270 Aspergillus niger uncharacterized protein XP_001391313.3 451826 R 5061 CDS An07g02280 4981495 454098..455117 IV 1 NT_166523.1 Title: questionable ORF; uncharacterized protein 455117 4981495 An07g02280 Aspergillus niger uncharacterized protein XP_001391314.1 454098 D 5061 CDS An07g02290 4981496 complement(join(455231..456119,456235..456332)) IV 1 NT_166523.1 Function: calcineurin is a calcium-dependent,calmodulin stimulated protein phoshatase.; Similarity: the predicted ORF shows weak similarity to the regulatory subunit of calcineurin from several spezies, but the predicted protein probably lacks at least one of the four calcium-binding sites.; Title: strong similarity to hypothetical protein CAE76397.1 - Neurospora crassa; uncharacterized protein 456332 4981496 An07g02290 Aspergillus niger uncharacterized protein XP_001391315.3 455231 R 5061 CDS An07g02300 4981497 complement(join(457196..457744,457835..458653,458709..459271,459339..459435)) IV 1 NT_166523.1 Complex: rsc8 is the eighth largest subunit of RSC,a fifteen-protein chromatin remodeling complex and related to the Swi/snf Complex.; Function: rsc8 as a component of the chromatin remodeling complex RSC is supposed to enable chromatin remodeling for transcriptional regulation of genes.; Remark: rsc8 of S. cerevisiae is also called SWH3 or YFR037C.; Title: strong similarity to chromatin remodeling gene transcription regulator Rsc8 - Saccharomyces cerevisiae; nucleus; See PMID 9121424; uncharacterized protein 459435 4981497 An07g02300 Aspergillus niger uncharacterized protein XP_059600866.1 457196 R 5061 CDS An07g02310 4981498 complement(460023..460688) IV 1 NT_166523.1 Catalytic activity: RX + glutathione <=> HX + R-S-glutathione.; Function: the function of glutathione S-transferases (GST) is the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and the isoenzymes appear to play a central role in the parasite detoxification system.; Remark: the predicted ORF overlaps with EST BE759905 of A. niger.; Similarity: the predicted ORF shows similarity to some glutathione S-transferases from several spezies.; Title: strong similarity to glutathione transferase D27 - Drosophila melanogaster; uncharacterized protein 460688 4981498 An07g02310 Aspergillus niger uncharacterized protein XP_059600867.1 460023 R 5061 CDS An07g02320 84591297 join(460908..461016,461174..461295,461411..461458) IV 1 NT_166523.1 Title: questionable ORF; uncharacterized protein 461458 84591297 An07g02320 Aspergillus niger uncharacterized protein XP_059600868.1 460908 D 5061 CDS An07g02350 4981502 complement(462945..465116) IV 1 NT_166523.1 Similarity: the similarity to the myb-like protein of S. pompe is restricted to the inner domain of the predicted ORF, reaching from amino acid 115 to 480, for which a DNA-binding domain of the SANT type is predicted.; Title: similarity to hypothetical myb-like DNA-binding - Schizosaccharomyces pombe; See PMID 8882580; uncharacterized protein 465116 4981502 An07g02350 Aspergillus niger uncharacterized protein XP_001391319.1 462945 R 5061 CDS An07g02360 4981503 join(467217..467297,467352..467781,467837..468326,468432..468652,468700..468935,469117..469314) IV 1 NT_166523.1 Catalytic activity: 6-hydroxy-D-nicotine oxidases convert (R)-6-hydroxynicotine + H(2)O + O(2) to 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H(2)O(2).; Function: A. oxidans 6-HDNO is involved in nicotine-acetyl-CoA catabolism.; Remark: the N-terminal region from amino acid 1 to 230 of the predicted ORF shows strong similarity to several FAD-binding domain containing proteins.; Remark: the group of FAD-binding domain proteins consists of various enzymes that use FAD as a co-factor,most of the enzymes are similar to oxygen oxidoreductases.; Title: similarity to 6-hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans; uncharacterized protein 469314 4981503 An07g02360 Aspergillus niger uncharacterized protein XP_001391320.3 467217 D 5061 CDS An07g02370 4981504 join(469758..469926,469974..469993,470048..470081,470126..470576,470624..470719,470773..471055,471139..471269,471434..471503,471743..471785,471860..471934,472058..472077,472135..472504,472564..472721) IV 1 NT_166523.1 Function: the M. grisea PTH11 gene product is presumably involved in host surface recognition and can activate appressorium differentiation in response to inductive surface cues.; Remark: the predicted ORF shows similarities to an integral membrane protein of M. grisea in its N-terminal region including amino acid 10 to 280.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529; uncharacterized protein 472721 4981504 An07g02370 Aspergillus niger uncharacterized protein XP_001391321.3 469758 D 5061 CDS An07g02380 4981505 join(473415..474006,474172..474653) IV 1 NT_166523.1 Function: TRI7 of F. sporotrichioides is required for acetylation of the oxygen on C-4 of T-2 toxin.; Pathway: TRI7 of F. sporotrichioides contributes in the trichothecene T2-toxin synthesis.; Remark: trichothecenes are sesquiterpenoid mycotoxins and act as protein synthesis inhibitors for eukaryotic organisms.; Title: weak similarity to T-2 toxin biosynthesis protein TRI7 - Fusarium sporotrichioides; See PMID 11352533; uncharacterized protein 474653 4981505 An07g02380 Aspergillus niger uncharacterized protein XP_059600869.1 473415 D 5061 CDS An07g02390 4981506 join(476305..476743,476799..477046) IV 1 NT_166523.1 hypothetical protein 477046 4981506 An07g02390 Aspergillus niger hypothetical protein XP_059600870.1 476305 D 5061 CDS An07g02400 4981507 join(481047..481448,481495..481845) IV 1 NT_166523.1 Title: similarity to hypothetical protein encoded by An18g00950 - Aspergillus niger; uncharacterized protein 481845 4981507 An07g02400 Aspergillus niger uncharacterized protein XP_059600871.1 481047 D 5061 CDS An07g02410 84591298 complement(join(482393..482554,482612..482728)) IV 1 NT_166523.1 Title: weak similarity to hypothetical protein encoded by An14g05600 - Aspergillus niger; uncharacterized protein 482728 84591298 An07g02410 Aspergillus niger uncharacterized protein XP_059600872.1 482393 R 5061 CDS An07g02420 10098318 complement(join(483032..483273,483385..483555,483626..483800)) IV 1 NT_166523.1 Remark: blastp matches are unspecific.; hypothetical protein 483800 10098318 An07g02420 Aspergillus niger hypothetical protein XP_059600873.1 483032 R 5061 CDS An07g02430 84591299 complement(join(485758..486199,486385..486415,486448..486493,486711..486713)) IV 1 NT_166523.1 hypothetical protein 486713 84591299 An07g02430 Aspergillus niger hypothetical protein XP_059600874.1 485758 R 5061 CDS An07g02440 4981511 complement(join(488203..488251,488322..490294)) IV 1 NT_166523.1 Catalytic activity: rat microsomal carboxylesterase catalyzes the reaction of a carboxylic ester + H2O = an alcohol + a carboxylic anion.; Function: rat microsomal carboxylesterase is involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. hydrolyzes omicron-nitrophenyl acetate and alpha-naphthyl acetate. it also hydrolyzes acetanilide and, distinctively,palmitoyl-Coa.; Remark: liver carboxylesterase 4, carboxyesterase ES-4 and microsomal palmitoyl-CoA hydrolase are alternative names for kidney microsomal carboxylesterase.; Similarity: belongs to the type-B carboxylesterase/lipase family.; Title: similarity to kidney microsomal carboxylesterase - Rattus norvegicus; See PMID 7961958; See PMID 8611161; uncharacterized protein 490294 4981511 An07g02440 Aspergillus niger uncharacterized protein XP_001391328.3 488203 R 5061 CDS An07g02450 4981512 491143..>491883 IV 1 NT_166523.1 Remark: the ORF encoded protein is C-terminally truncated due to the end of contig.; hypothetical protein [truncated ORF] 491883 4981512 An07g02450 Aspergillus niger hypothetical protein [truncated ORF] XP_001391329.3 491143 D 5061 CDS An07g02460 84591300 join(492489..492533,492645..492720,493347..493586,493698..493831) IV 1 NT_166523.1 hypothetical protein 493831 84591300 An07g02460 Aspergillus niger hypothetical protein XP_059600875.1 492489 D 5061 CDS An07g02470 84591301 complement(join(494863..494950,495046..495125,495457..495573)) IV 1 NT_166523.1 hypothetical protein 495573 84591301 An07g02470 Aspergillus niger hypothetical protein XP_059600876.1 494863 R 5061 CDS An07g02480 84591302 join(496519..496612,496636..496780,497060..497117) IV 1 NT_166523.1 hypothetical protein 497117 84591302 An07g02480 Aspergillus niger hypothetical protein XP_059600877.1 496519 D 5061 CDS An07g02490 84591303 complement(join(497397..497640,497724..497806,497896..497973)) IV 1 NT_166523.1 hypothetical protein 497973 84591303 An07g02490 Aspergillus niger hypothetical protein XP_059600878.1 497397 R 5061 CDS An07g02500 84591304 complement(join(499025..499028,499085..499228,499299..499311,499393..499438,499527..499606,499692..499983,500193..500198)) IV 1 NT_166523.1 Title: weak similarity to protein fragment SEQ ID NO:44609 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 500198 84591304 An07g02500 Aspergillus niger uncharacterized protein XP_059600879.1 499025 R 5061 CDS An07g02510 4981518 501727..504180 IV 1 NT_166523.1 Remark: blastp matches are unspecific.; Title: strong similarity to hypothetical protein encoded by An08g12110 - Aspergillus niger; uncharacterized protein 504180 4981518 An07g02510 Aspergillus niger uncharacterized protein XP_001391335.1 501727 D 5061 CDS An07g02520 84591305 complement(join(504382..504414,504648..504965)) IV 1 NT_166523.1 hypothetical protein 504965 84591305 An07g02520 Aspergillus niger hypothetical protein XP_059600880.1 504382 R 5061 CDS An07g02530 4981520 complement(join(505945..506176,506223..506449,506502..506667,506713..508078,508126..508975,509063..509641)) IV 1 NT_166523.1 Phenotype: yeast bst1 mutants how enhanced leaking from the ER of the ER resident proteins Kar2p and Pdi1p.; Phenotype: yeast bst1 mutants show reduced secretion of some secretory proteins.; Remark: YFL025c is the systematic name for yeast BST1.; Title: similarity to negative regulator of COPII vesicle formation Bst1 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 11208122; See PMID 8862519; uncharacterized protein 509641 4981520 An07g02530 Aspergillus niger uncharacterized protein XP_001391337.1 505945 R 5061 CDS An07g02540 4981521 complement(join(511729..512382,512449..513123,513183..513392)) IV 1 NT_166523.1 Function: JEN1 of S. cerevisiae is a lactate and pyruvate proton-driven symporter.; Induction: JEN1 of S. cerevisiae is induced by lactate.; Phenotype: Deletion of JEN1 in S. cerevisiae results in slow growth of yeast on synthetic medium supplemented with L-lactate.; Repression: JEN1 of S. cerevisiae is repressed by glucose.; Similarity: JEN1 of S. cerevisiae belongs to the sialate:H+ symporter (SHS) group of the major facilitator superfamily (MFS) of transport proteins.; Title: similarity to carboxylic acid transport protein Jen1 - Saccharomyces cerevisiae; plasma membrane; See PMID 10198029; See PMID 10879467; uncharacterized protein 513392 4981521 An07g02540 Aspergillus niger uncharacterized protein XP_001391338.1 511729 R 5061 CDS An07g02550 84591306 complement(join(513754..513850,513933..514142,514313..514377,514431..514547)) IV 1 NT_166523.1 Title: weak similarity to DNA dependent ATPase/DNA helicase B - Saccharomyces cerevisiae; uncharacterized protein 514547 84591306 An07g02550 Aspergillus niger uncharacterized protein XP_059600881.1 513754 R 5061 CDS An07g02560 4981523 complement(join(514903..514920,514954..515032,515085..516280)) IV 1 NT_166523.1 Catalytic activity: dimethylallyltryptophan synthase of C. purpurea catalyses the reaction dimethylallyl diphosphate + L-tryptophan = diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan.; Function: dimethylallyltryptophan synthase of C. purpurea (also known as tryptophan dimethylallyltransferase) is a prenyltransferase, which catalyses the first step in ergot alkaloid biosynthesis.; Title: similarity to dimethylallyltryptophan synthase dmaW - Claviceps purpurea; See PMID 1605639; See PMID 7488077; See PMID 11036684; uncharacterized protein 516280 4981523 An07g02560 Aspergillus niger uncharacterized protein XP_001391340.3 514903 R 5061 CDS An07g02570 4981524 join(517234..518154,518214..518335,518394..518692,518752..518853,518964..519169) IV 1 NT_166523.1 Pathway: TRI11 from F. sporotrichioides is involved in the trichothecene biosynthesis. Trichothecenes are sesquiterpenoid toxins that act by inhibiting protein biosynthesis.; Remark: disruption of TRI11 gene from Fusarium sporotrichioides results in an altered trichothecene production phenotype characterized by the accumulation of isotrichodermin, a trichothecene pathway intermediate.; Similarity: TRI11 from F. sporotrichioides belongs to the cytochrome p450 family.; Title: strong similarity to cytochrome P450 monooxygenase TRI11 - Fusarium sporotrichioides; See PMID 9435078; uncharacterized protein 519169 4981524 An07g02570 Aspergillus niger uncharacterized protein XP_059600882.1 517234 D 5061 CDS An07g02580 84591307 complement(join(519414..519489,519675..519997)) IV 1 NT_166523.1 Remark: blastp matches are unspecific.; hypothetical protein 519997 84591307 An07g02580 Aspergillus niger hypothetical protein XP_059600883.1 519414 R 5061 CDS An07g02590 84591308 complement(join(521052..521129,521178..521216,521388..521435,521587..521688,521798..521896,522610..522716,522763..522873,523133..523142)) IV 1 NT_166523.1 Title: weak similarity to hypothetical protein F13K23.8 - Arabidopsis thaliana; uncharacterized protein 523142 84591308 An07g02590 Aspergillus niger uncharacterized protein XP_059600884.1 521052 R 5061 CDS An07g02600 4981527 join(523791..523967,524065..524417,524473..524590) IV 1 NT_166523.1 Similarity: G. cingulata homolog is similar to glutenins.; Title: similarity to hypothetical glutamine rich protein AAB92223.1 - Glomerella cingulata; uncharacterized protein 524590 4981527 An07g02600 Aspergillus niger uncharacterized protein XP_001391344.1 523791 D 5061 CDS An07g02620 84591309 join(525284..525371,525417..525517) IV 1 NT_166523.1 hypothetical protein 525517 84591309 An07g02620 Aspergillus niger hypothetical protein XP_059600885.1 525284 D 5061 CDS An07g02630 84591310 complement(join(526706..526732,526800..527027)) IV 1 NT_166523.1 hypothetical protein 527027 84591310 An07g02630 Aspergillus niger hypothetical protein XP_059600886.1 526706 R 5061 CDS An07g02640 84591311 complement(join(527421..527633,527714..527782,527891..527944)) IV 1 NT_166523.1 hypothetical protein 527944 84591311 An07g02640 Aspergillus niger hypothetical protein XP_059600887.1 527421 R 5061 CDS An07g02650 4981532 join(528227..528414,528488..531494) IV 1 NT_166523.1 Catalytic activity: EF-3 stimulates binding of EF-1:GTP:aa-tRNA ternary complex to the ribosomal A site by facilitated release of the deacylated tRNA from the E site.; Function: the S. cerevisiae homolog YEF3/eEF-3 elongation factor 3 is a cytosolic protein required by the fungal ribosomes for protein synthesis. The requirement for EF-3 is unique to fungi.; Remark: S. cerevisiae EF-3 is a member of the non-transporter group of the ATP-binding cassette (ABC) superfamily.; Title: strong similarity to translation elongation factor 3 Yef3 - Saccharomyces cerevisiae; uncharacterized protein 531494 4981532 An07g02650 Aspergillus niger uncharacterized protein XP_001391348.1 528227 D 5061 CDS An07g02660 84591312 complement(join(531879..531953,532048..532113,532189..532315,532395..532525,532636..532759,532864..533020,533453..533548,533638..533659)) IV 1 NT_166523.1 hypothetical protein 533659 84591312 An07g02660 Aspergillus niger hypothetical protein XP_059600888.1 531879 R 5061 CDS An07g02670 84591313 join(533967..534079,534380..534542,534721..534790,534935..535020,535117..535176) IV 1 NT_166523.1 hypothetical protein 535176 84591313 An07g02670 Aspergillus niger hypothetical protein XP_059600889.1 533967 D 5061 CDS An07g02680 4981535 join(535925..536151,536662..536891,536942..538017,538063..538416,538477..538761,538807..539450,539521..539947) IV 1 NT_166523.1 Complex: S. cerevisiae Chl12p/Cft18p is a subunit in an alternative replication factor c (RFC) complex RFC(Ctf18p, Ctf8p, Dcc1p). Ctf18p, Ctf8p, and Dcc1p interact physically in a complex with Rfc2p, Rfc3p, Rfc4p,and Rfc5p.; Function: RFC(Ctf18p, Ctf8p, Dcc1p) is required for sister chromatid cohesion and faithful chromosome transmission durin mitosis.; Remark: an alternative gene name for the S. cerevisiae homolog CHL12 is CFT18.; Title: strong similarity to protein required for accurate chromosome transmission Chl12 - Saccharomyces cerevisiae; uncharacterized protein 539947 4981535 An07g02680 Aspergillus niger uncharacterized protein XP_059600890.1 535925 D 5061 CDS An07g02690 4981536 join(540284..540352,540483..541637) IV 1 NT_166523.1 Function: PBK1 of H. sapiens could be involved in the regulation of proliferation/ differentiation and potentially in invasion of trophoblast cells.; Remark: PBK1 of H. sapiens is expressed in first trimester placentae but not in term placentae in the proximal parts of cell islands and in closely adjacent villous cytotrophoblast.; Remark: the ORF is shorter than PBK1 of H. sapiens (407 compared to 517 amino acids) and the similarity between the two proteins spans only a stretch of about 250 amino acids.; Remark: the ORF overlaps with the A. niger EST an_2460 in EMBLEST:BE759612.; Title: similarity to hypothetical regulational protein PBK1 - Homo sapiens; See PMID 9859858; uncharacterized protein 541637 4981536 An07g02690 Aspergillus niger uncharacterized protein XP_001391352.1 540284 D 5061 CDS An07g02700 4981537 complement(join(541962..542536,542636..542804,542877..543179)) IV 1 NT_166523.1 Complex: ETFA of H. sapiens is a heterodimer of an alpha and a beta chain, that binds one molecule of FAD.; Function: ETFA of H. sapiens is an electron acceptor for any of several dehydrogenases in the mitochondrial matrix and it transfers the electrons to the mitochondrial respiratory chain via electron-transferring-flavoprotein dehydrogenase.; Phenotype: mutations in ETFA of H. sapiens can cause glutaricaciduria type IIA (excessive excretion of glutaric and other acids).; Remark: ETFA of H. sapiens belongs to the superfamily of electron transfer flavoprotein alpha chains.; Title: strong similarity to electron transfer flavoprotein alpha chain precursor ETFA - Homo sapiens; localisation:mitochondrion; See PMID 3170610; uncharacterized protein 543179 4981537 An07g02700 Aspergillus niger uncharacterized protein XP_001391353.1 541962 R 5061 CDS An07g02710 84591314 complement(join(543649..543773,544538..544741,545200..545375,545884..546007,546649..546753,546847..546982,547396..547501,548161..548438,548753..548887)) IV 1 NT_166523.1 Remark: the ORF has an unusual exon/intron structure for A. niger.; Title: questionable ORF; uncharacterized protein 548887 84591314 An07g02710 Aspergillus niger uncharacterized protein XP_059600891.1 543649 R 5061 CDS An07g02720 84591315 complement(join(549006..549119,549166..549580,549611..549624)) IV 1 NT_166523.1 hypothetical protein 549624 84591315 An07g02720 Aspergillus niger hypothetical protein XP_059600892.1 549006 R 5061 CDS An07g02730 4981540 join(551053..551908,551971..552545) IV 1 NT_166523.1 Function: Psu1 of S. pombe presumably plays an essential role in cell wall synthesis.; Phenotype: disruption of the gene for Psu1 in S. pombe revealed that it is essential for growth, and the null phenotype showed the swelling of cells followed by eventual lysis.; Remark: the ORF is rich in histidine and serine.; Remark: the ORF overlaps with the A. niger ESTs AN03F11 and ID NO:3882 in EMBLEST:ANI239807 and in PATENTDNA:AAF11359, respectively.; Title: strong similarity to SUN family protein su1p - Schizosaccharomyces pombe; See PMID 10462482; uncharacterized protein 552545 4981540 An07g02730 Aspergillus niger uncharacterized protein XP_059600893.1 551053 D 5061 CDS An07g02740 84591316 join(554689..556197,556247..556273) IV 1 NT_166523.1 Remark: the ORF is rich in serine.; Remark: the similarity between the ORF and the S. pombe protein extends only over a stretch of about 200 amino acids.; Title: similarity to hypothetical protein encoded by SPAP14E8.02 - Schizosaccharomyces pombe; uncharacterized protein 556273 84591316 An07g02740 Aspergillus niger uncharacterized protein XP_059600894.1 554689 D 5061 CDS An07g02750 84591317 557362..557658 IV 1 NT_166523.1 Remark: the ORF is short in sequence.; hypothetical protein 557658 84591317 An07g02750 Aspergillus niger hypothetical protein XP_059600895.1 557362 D 5061 CDS An07g02760 4981543 join(558233..558251,558332..558376,558491..560592,560648..560939,560985..561142,561190..561465,561515..561820,561869..562051) IV 1 NT_166523.1 Function: human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon.; Remark: NMD rids eukaryotic cells of aberrant mRNAs containing premature termination codons.; Remark: tethering of Upf of H. sapiens to the 3'UTR of beta-globin mRNA elicits nonsense-mediated decay (NMD).; Title: strong similarity to hUPF2 - Homo sapiens; See PMID 11163187; uncharacterized protein 562051 4981543 An07g02760 Aspergillus niger uncharacterized protein XP_059600896.1 558233 D 5061 CDS An07g02770 4981544 complement(join(563401..563683,563752..564281)) IV 1 NT_166523.1 Similarity: the ORF is shorter than the S. cerevisiae protein (270 compared to 427 amino acids), the similarity between the two proteins is very high at a central stretch of about 50 amino acids.; Title: strong similarity to hypothetical protein YKL195w - Saccharomyces cerevisiae; uncharacterized protein 564281 4981544 An07g02770 Aspergillus niger uncharacterized protein XP_001391360.3 563401 R 5061 CDS An07g02780 4981545 join(564976..565030,565072..565800,565845..565882) IV 1 NT_166523.1 Function: inv of M. musculus is essential for the left-right axis determination.; Remark: the ORF is much shorter than inv of M. musculus (273 compared to 1062 amino acids), the ORF is similar to the ankyrin domain repeated in inv of M. musculus.; Title: similarity to left-right axis determination protein inversin inv - Mus musculus; See PMID 9771707; uncharacterized protein 565882 4981545 An07g02780 Aspergillus niger uncharacterized protein XP_059600897.1 564976 D 5061 CDS An07g02790 84591318 join(566201..566321,566394..566473,566586..566627) IV 1 NT_166523.1 Similarity: the similarity to mTPK of M. musculus is restricted to a short stretch at the N-terminusaof the M-musczlus protein.; Title: weak similarity to thiamin pyrophosphokinase mTPK1 - Mus musculus; See PMID 10567383; uncharacterized protein 566627 84591318 An07g02790 Aspergillus niger uncharacterized protein XP_059606637.1 566201 D 5061 CDS An07g02800 4981547 complement(join(567745..568465,568514..568753,568848..568927)) IV 1 NT_166523.1 Similarity: the predicted ORF is 67 amino acids shorter at the N-terminus and 95 amino acids at the C-terminal end.; Title: strong similarity to hypothetical protein 2E4.30 - Neurospora crassa; uncharacterized protein 568927 4981547 An07g02800 Aspergillus niger uncharacterized protein XP_001391363.1 567745 R 5061 CDS An07g02810 4981548 complement(join(569812..570071,570171..570593,570652..570949,571054..571344,571451..571525)) IV 1 NT_166523.1 Similarity: the predicted ORF shows similarity to several mitochondrial carrier proteins from different species.; Title: strong similarity to hypothetical mitochondrial carrier protein YMR166c - Saccharomyces cerevisiae; uncharacterized protein 571525 4981548 An07g02810 Aspergillus niger uncharacterized protein XP_059606638.1 569812 R 5061 CDS An07g02820 4981549 complement(join(572204..572757,572814..573037,573209..573226,573288..573355)) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein SPBC1539.04 - Schizosaccharomyces pombe; uncharacterized protein 573355 4981549 An07g02820 Aspergillus niger uncharacterized protein XP_001391365.1 572204 R 5061 CDS An07g02833 84591319 complement(574336..574689) IV 1 NT_166523.1 Title: strong similarity to EST SEQ ID NO:4186 from patent WO200056762-A2 - Aspergillus niger; uncharacterized protein 574689 84591319 An07g02833 Aspergillus niger uncharacterized protein XP_059606639.1 574336 R 5061 CDS An07g02840 4981551 complement(join(575079..575714,575774..576240,576305..576419)) IV 1 NT_166523.1 Similarity: the ORF overlaps with the A. niger EST sequence in EMBLEST:BE759034 an_3317.; Title: strong similarity to cell division controll protein CDC3 - Candida albicans; See PMID 4203183; uncharacterized protein 576419 4981551 An07g02840 Aspergillus niger uncharacterized protein XP_001391367.3 575079 R 5061 CDS An07g02850 84591320 579071..579202 IV 1 NT_166523.1 Remark: it is assumed, that sequences excluded from the ORF are CDS, but as the submitted sequence contains stop codons/putative frameshifts, the region was not included in the ORF sequence.; Remark: the ORF overlaps with A. niger EST in PATENTDNA:AAF11720 EST SEQ ID NO:4243.; Title: strong similarity to EST SEQ ID NO:4243 from patent WO200056762-A2 - Aspergillus niger; uncharacterized protein 579202 84591320 An07g02850 Aspergillus niger uncharacterized protein XP_059606640.1 579071 D 5061 CDS An07g02860 4981553 complement(join(579998..580272,580357..580433,580487..580720,580776..580907,580961..581200,581250..581779,581856..582078,582131..582132)) IV 1 NT_166523.1 Function: Pob3 of S. cerevisiae is an essential nuclear protein, which physically and genetically interacts with the catalytic subunit of DNA polymerase alpha and probably modulates chromatin function during replication as well as in transcription.; Similarity: the predicted ORF is 107 amino acids longer at the C-terminus than S. cerevisiae Pob3.; Title: strong similarity to chromatin modelling protein Pob3 - Saccharomyces cerevisiae; nucleus; See PMID 9199353; See PMID 10413469; See PMID 10924459; uncharacterized protein 582132 4981553 An07g02860 Aspergillus niger uncharacterized protein XP_059606641.1 579998 R 5061 CDS An07g02870 4981554 join(585182..586334,586389..588641,588699..588934) IV 1 NT_166523.1 Function: Rax2 of S. cerevisiae functions as a marker, indicating the cell poles (budding direction).; Remark: Rax2 of S. cerevisiae is inherited immutably at the cell cortex for multiple generations, and is shown to have a half-life exceeding several generations.; Title: similarity to membrane protein Rax2 -Saccharomyces cerevisiae; See PMID 11110666; uncharacterized protein 588934 4981554 An07g02870 Aspergillus niger uncharacterized protein XP_001391370.1 585182 D 5061 CDS An07g02880 4981555 join(591154..591265,591334..591904,591964..592592,592651..593474) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein EAA57627.1 - Aspergillus nidulans; uncharacterized protein 593474 4981555 An07g02880 Aspergillus niger uncharacterized protein XP_001391371.3 591154 D 5061 CDS An07g02890 4981556 complement(join(595721..596133,596197..596318,596376..597058)) IV 1 NT_166523.1 Function: OOG1 of R. norvegicus is a DNA repair enzyme that exicises the oxidation product 8-hydroxyguanine (8-OH-G) out of the DNA.; Remark: 8-OH-G is one of the major DNA oxidation products caused by oxygen radicals (produced metabolically or induced by external agents) and ionizing radiation.; Remark: OOG1 of R. norvegicus belongs to the OGG1 family 1.; Remark: OOG1 of R. norvegicus has two functionalities: a 8-oxoguanine-DNA-glycosylase (EC 3. 2. 2. -) and a DNA-(apurinic or apyrimidinic site) lyase (EC 4. 2. 99. 18).; Title: strong similarity to 8-oxoguanine-DNA-glycosylase OOG1 - Rattus norvegicus; nucleus; See PMID 9587483; See PMID 10426809; See PMID 10882853; uncharacterized protein 597058 4981556 An07g02890 Aspergillus niger uncharacterized protein XP_059606642.1 595721 R 5061 CDS An07g02900 4981557 join(597475..597502,597565..597611,597649..598195,598253..598866,598913..599174,599224..599522) IV 1 NT_166523.1 Complex: U2AF50 of D. melanogaster forms together with the U2AF small subunit the heterodimeric pre-mRNA splicing factor U2AF.; Function: U2AF50 of D. melanogaster is necessary for the splicing of pre-mRNA.; Remark: U2AF binds site specifically to the intron pyrimidine tract between the branchpoint and the 3' splice site and targets U2 snRNP to the branch site at an early step in spliceosome assembly.; Remark: U2AF plays a critical role in 3' splice site selection.; Remark: U2AF50 of D. melanogaster belongs to the SR family of splicing factors.; Remark: the RS domains of the U2AF components of D. melanogaster are essential for RNA binding.; Similarity: the ORF is 127 amino acids shorter at the N-terminus than U2AF50 of D. melanogaster.; Title: strong similarity to splicing factor U2AF large chain U2AF50 - Drosophila melanogaster; nucleus; See PMID 9528748; See PMID 9632785; See PMID 7692602; uncharacterized protein 599522 4981557 An07g02900 Aspergillus niger uncharacterized protein XP_059606643.1 597475 D 5061 CDS An07g02910 84591321 join(599766..599789,599932..599972,600035..600090,600147..600187,600344..600541,600714..600860) IV 1 NT_166523.1 Remark: the ORF has an unusual exon/intron structure for A. niger.; hypothetical protein 600860 84591321 An07g02910 Aspergillus niger hypothetical protein XP_059606644.1 599766 D 5061 CDS An07g02920 84591322 join(601344..601390,601554..601591,601633..601736) IV 1 NT_166523.1 Remark: the ORF has an unusual exon/intron structure and short length (62 amino acids).; Similarity: the ORF shows similarity over a stretch of 47 amino acids to patent WO9306215-A (a hypothetical M. musculus nuclear receptor XR5).; hypothetical protein 601736 84591322 An07g02920 Aspergillus niger hypothetical protein XP_059606645.1 601344 D 5061 CDS An07g02930 4981560 complement(join(603208..604241,604298..604616,604712..604807,604855..604950)) IV 1 NT_166523.1 hypothetical protein 604950 4981560 An07g02930 Aspergillus niger hypothetical protein XP_059606646.1 603208 R 5061 CDS An07g02940 84591323 complement(join(606266..606326,606510..606691)) IV 1 NT_166523.1 Remark: the ORF has an unusual exon/intron structure for A. niger and short length (80 amino acids).; Title: questionable ORF; uncharacterized protein 606691 84591323 An07g02940 Aspergillus niger uncharacterized protein XP_059606647.1 606266 R 5061 CDS An07g02950 84591324 join(607816..607967,608284..608638,608723..608755,608983..609057,609139..609462,609570..609645,609692..609871,610002..610088,610180..610355,610443..610559) IV 1 NT_166523.1 Remark: the ORF has an unusual exon/intron structure for A. niger.; hypothetical protein 610559 84591324 An07g02950 Aspergillus niger hypothetical protein XP_059606648.1 607816 D 5061 CDS An07g02960 4981563 join(611545..611746,611812..611844,612343..612389,612454..612627) IV 1 NT_166523.1 Similarity: the ORF overlaps with A. niger EST from database entries EMBLEST:BE758805 (an_3049),EMBLEST:BE759822 (an_2743), EMBLEST:BE759687 (an_2554),EMBLEST:BE760011 (an_2967) and PATENTDNA:AAF12010 (EST SEQ ID NO:4002).; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S13.e - Saccharomyces cerevisiae; cytoplasm; 40S ribosomal protein uS15 612627 4981563 An07g02960 Aspergillus niger 40S ribosomal protein uS15 XP_001391379.1 611545 D 5061 CDS An07g02970 4981564 complement(join(612803..612832,612887..613438,613507..614977,615020..615519)) IV 1 NT_166523.1 Remark: the translated sequence of the ORF probably contains some introns.; Title: strong similarity to hypothetical conserved protein SPBC146.06c - Schizosaccharomyces pombe; uncharacterized protein 615519 4981564 An07g02970 Aspergillus niger uncharacterized protein XP_059606649.1 612803 R 5061 CDS An07g02980 4981565 join(615812..615829,616062..616369,616466..616556) IV 1 NT_166523.1 Similarity: the similarity of the ORF to the hypothetical protein YDR469w of S. cerevisiae is restricted to the second half of the ORF, where the homology is relatively high.; Title: similarity to hypothetical protein YDR469w -Saccharomyces cerevisiae; uncharacterized protein 616556 4981565 An07g02980 Aspergillus niger uncharacterized protein XP_001391381.3 615812 D 5061 CDS An07g02990 4981566 complement(join(618374..618834,618897..619243,619325..619424,619508..619547)) IV 1 NT_166523.1 Function: AUF1 of H. sapiens is a component of the ribonucleosomes, that binds with high affinity to mRNA molecules, which contain AU-rich elements (ARES), a process that might control mRNA turnover.; Remark: AUF1 of H. sapiens is also called heterologous nuclear ribonucleoprotein D0, HNRNP D0,AU-rich element RNA-binding protein 1 or HNRPD.; Similarity: the alignment between the ORF and AUF1 of H. sapiens encompasses solely the N-terminal half of the ORF.; Title: similarity to RNA-binding protein AUF1 - Homo sapiens; See PMID 9932457; See PMID 11514570; uncharacterized protein 619547 4981566 An07g02990 Aspergillus niger uncharacterized protein XP_001391382.1 618374 R 5061 CDS An07g03000 4981567 complement(join(620300..621380,621430..623885)) IV 1 NT_166523.1 Function: BR140 of H. sapiens is a probable transcription regulator.; Remark: BR140 of H. sapiens is also called peregrin,bromodomain and PDH finger-containing protein 1 or BRPF1.; Remark: bromodomains are found in several DNA-binding proteins; the PHD finger is a C4HC3 zinc-finger-like motif found in nuclear proteins thought to be involved in chromatin-mediated transcriptional regulation.; Similarity: the ORF shows strong similarity to several BR140 homologues from different species.; Similarity: the similarity of the predicted ORF to BR130 of H. sapiens is locally high in the region between amino acid 337 and 828 of the ORF.; Title: strong similarity to zinc-finger protein BR140 - Homo sapiens; uncharacterized protein 623885 4981567 An07g03000 Aspergillus niger uncharacterized protein XP_001391383.1 620300 R 5061 CDS An07g03005 4981568 624501..624953 IV 1 NT_166523.1 hypothetical protein 624953 4981568 An07g03005 Aspergillus niger hypothetical protein XP_059606650.1 624501 D 5061 CDS An07g03020 4981569 complement(join(625564..626400,626470..626661,626707..626854,626918..627033)) IV 1 NT_166523.1 Function: O-sialoglycoprotein endopeptidase is a neutral metalloprotease (glycoprotease), which is specific for O-sialoglycoproteins such as glycophorin A, from which the 31-Arg-|-Asp-32 bond is cleaved.; Function: O-sialoglycoprotein endopeptidases do not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated.; Repression: O-sialoglycoprotein endopeptidases are inhibited by EDTA (100 milli M) and 1,10-phenanthroline.; Similarity: the ORF shows strong similarity to O-sialoglycoprotein endopeptidases, especially from bacteria.; Title: strong similarity to O-sialoglycoprotein endopeptidase A1 - Pasteurella haemolytica; extracellular/secretion proteins; See PMID 9606137; See PMID 9689740; See PMID 1885539; uncharacterized protein 627033 4981569 An07g03020 Aspergillus niger uncharacterized protein XP_059606651.1 625564 R 5061 CDS An07g03030 84591325 complement(627637..627999) IV 1 NT_166523.1 Remark: the A. niger EST from patent WO200056762-A2 is found in PATENTDNA:AAF11604 as EST SEQ ID NO:4127.; Similarity: the ORF overlaps with A. niger ESTs an_2812 (EMBLEST:BE759877), an_2694 (EMBLEST:BE759780),an_2624 (EMBLEST:BE759723) and an_017 (EMBLEST:BE760090).; Title: strong similarity to EST SEQ ID NO:4127 from patent WO200056762-A2 - Aspergillus niger; uncharacterized protein 627999 84591325 An07g03030 Aspergillus niger uncharacterized protein XP_059606652.1 627637 R 5061 CDS An07g03040 4981571 complement(join(629319..631150,631226..632468)) IV 1 NT_166523.1 Similarity: the similarity of the predicted ORF to the N. crassa protein is restricted to the second half of the ORFs.; Title: similarity to hypothetical protein 15E11.80 -Neurospora crassa; uncharacterized protein 632468 4981571 An07g03040 Aspergillus niger uncharacterized protein XP_001391387.3 629319 R 5061 CDS An07g03050 4981572 join(636069..636102,636176..636408,636476..637177) IV 1 NT_166523.1 Similarity: the predicted ORF is 425 amino acids shorter at the N-terminus than the putative integral membrane protein SCC53. 26c of S. coelicolor and the similarity is restricted to an C-terminal region of the S. coelicolor protein.; Title: similarity to hypothetical integral membrane protein SCC53.26c - Streptomyces coelicolor; uncharacterized protein 637177 4981572 An07g03050 Aspergillus niger uncharacterized protein XP_001391388.1 636069 D 5061 CDS An07g03060 84591326 join(638100..638116,638147..638257,638334..638494,638595..638782,638867..638902,638955..639158) IV 1 NT_166523.1 hypothetical protein 639158 84591326 An07g03060 Aspergillus niger hypothetical protein XP_059606653.1 638100 D 5061 CDS An07g03070 4981574 join(640074..640253,640364..641557,641625..641787,641848..642398) IV 1 NT_166523.1 Function: ARALAR2 of H. sapiens is a calcium-dependent mitochondrial metabolite (possibly anionic) carrier, which might have a role in urea cycle function.; Remark: ARALAR2 of H. sapiens is also called SLC25A13, member 13 of solute carrier family 25 or citrin.; Title: strong similarity to mitochondrial carrier protein ARALAR2 - Homo sapiens; See PMID 10369257; See PMID 10610724; See PMID 10642534; uncharacterized protein 642398 4981574 An07g03070 Aspergillus niger uncharacterized protein XP_001391390.1 640074 D 5061 CDS An07g03080 4981575 complement(join(643307..643506,643591..644044)) IV 1 NT_166523.1 hypothetical protein 644044 4981575 An07g03080 Aspergillus niger hypothetical protein XP_001391391.1 643307 R 5061 CDS An07g03090 4981576 644362..650607 IV 1 NT_166523.1 Function: bimB of A. nidulans is involved in the nuclear division, probably as a component of the mitotic spindle.; Phenotype: a conditionally lethal mutation in the bimB gene of A. nidulans disrupts the normal regulatory patterns associated with mitotic events, e. g. DNA replication occurs in the absence of the completion of mitosis at restrictive temperature and large polyploid nuclei form after several hours.; Title: strong similarity to spindle pole body component bimB - Aspergillus nidulans; See PMID 1639810; uncharacterized protein 650607 4981576 An07g03090 Aspergillus niger uncharacterized protein XP_001391392.1 644362 D 5061 CDS An07g03100 4981577 join(650952..651216,651335..651555,651662..651856,651948..652133) IV 1 NT_166523.1 Catalytic activity: carboxylesterases catalyse a carboxylic ester + H(2)O <=> an alcohol + a carboxylic anion.; Title: strong similarity to esterase D ESD - Homo sapiens; uncharacterized protein 652133 4981577 An07g03100 Aspergillus niger uncharacterized protein XP_001391393.1 650952 D 5061 CDS An07g03110 4981578 complement(join(652388..652730,652765..653185,653240..653537,653585..653632,653686..653802,653858..653935)) IV 1 NT_166523.1 Remark: similarity to A. niger EST an_2343 EMBLEST:BE75951.; Similarity: the encoded protein shows also similarity to the N-terminal half of An13g02370.; Title: similarity to hypothetical protein CAD21104.1 - Neurospora crassa; uncharacterized protein 653935 4981578 An07g03110 Aspergillus niger uncharacterized protein XP_059606654.1 652388 R 5061 CDS An07g03120 4981579 complement(join(655606..656142,656204..656316,656369..656795)) IV 1 NT_166523.1 Title: similarity to protein SEQ ID NO:7732 from patent WO200253728-A2 - Candida albicans; uncharacterized protein 656795 4981579 An07g03120 Aspergillus niger uncharacterized protein XP_059606655.1 655606 R 5061 CDS An07g03130 4981580 join(657948..658782,658850..659475) IV 1 NT_166523.1 Function: MMT1 of S. cerevisiae is involved in the iron import in mitochondria, which is required for the biosynthesis of heme and various iron-sulfur proteins.; Remark: the systematic name of MMT1 from S. cerevisiae is YMR177W.; Similarity: the ORF shows similarity to several cation transporters.; Similarity: the similarity of MMT1 (and MMT2=YPL224c) from S. cerevisiae to the ORF starts around amino acid 100.; Title: strong similarity to mitochondrial cation transporter Mmt1 - Saccharomyces cerevisiae; See PMID 10383398; uncharacterized protein 659475 4981580 An07g03130 Aspergillus niger uncharacterized protein XP_001391396.1 657948 D 5061 CDS An07g03140 4981581 join(660494..660988,661056..662273) IV 1 NT_166523.1 Catalytic activity: XKS1 of S. cerevisiae converts ATP + D-xylulose <=> ADP + D-xylulose 5-phosphate.; Function: XKS1 of S. cerevisiae is necessary for growth in culture media with D-xylulose as the sole carbon source, which can induce the production of ethanol.; Phenotype: overexpression of XKS1 from S. cerevisiae negatively influenced cell growth in xylulose.; Title: strong similarity to D-xylulokinase Xks1 -Saccharomyces cerevisiae; See PMID 9595677; See PMID 10981687; See PMID 11461146; uncharacterized protein 662273 4981581 An07g03140 Aspergillus niger uncharacterized protein XP_001391397.1 660494 D 5061 CDS An07g03150 4981582 join(662883..662894,663119..665717,665765..666219,666278..666304) IV 1 NT_166523.1 Function: exportin-t of H. sapiens is a tRNA receptor, that shuttles between the nucleus and cytoplasm and exports tRNA out of the nucleus in a RanGTP-dependent manner.; Title: strong similarity to nuclear tRNA export receptor exportin-t - Homo sapiens; See PMID 9512417; See PMID 9660920; uncharacterized protein 666304 4981582 An07g03150 Aspergillus niger uncharacterized protein XP_001391398.1 662883 D 5061 CDS An07g03160 4981583 complement(join(666984..667046,667139..667478,667557..667788,667851..667959,668030..668157,668221..668264,668314..668390)) IV 1 NT_166523.1 Catalytic activity: transaldolases catalyse sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate.; Function: transaldolases are important for the balance of metabolites in the pentose-phoshapte pathway and together with transketolase, provides a link between the glycolytic and pentose-phosphate pathways.; Title: strong similarity to transaldolase talB -Synechocystis sp.; cytoplasm; uncharacterized protein 668390 4981583 An07g03160 Aspergillus niger uncharacterized protein XP_059606656.1 666984 R 5061 CDS An07g03170 4981584 join(670840..670879,670938..671028,671166..671601) IV 1 NT_166523.1 Catalytic activity: SDH3 of S. cerevisiae catalyzes succinate + ubiquinone <=> fumarate + ubiquinol.; Function: SDH3 of S. cerevisiae is the cytochrome b560 subunit of the respiratory complex II, which is responsible for the transfer of electrons from succinate to ubiquinone.; Induction: SDH3 of S. cerevisiae is activated in the presence of the HAP2 transcriptional activator.; Remark: SDH3 of S. cerevisiae is also called CYB3,YKL141W or YKL4.; Title: strong similarity to succinate dehydrogenase cytochrome b subunit Sdh3 - Saccharomyces cerevisiae; localisation:mitochondrion; uncharacterized protein 671601 4981584 An07g03170 Aspergillus niger uncharacterized protein XP_001391400.1 670840 D 5061 CDS An07g03180 84591327 join(672556..672600,672688..672771,672966..673053,673282..673407,673534..673598,673688..673942) IV 1 NT_166523.1 Remark: the predicted ORF contains long introns.; hypothetical protein 673942 84591327 An07g03180 Aspergillus niger hypothetical protein XP_059606657.1 672556 D 5061 CDS An07g03190 4981586 join(675311..675698,675769..676001,676124..676235,676313..676386,676575..676619,676996..677001,677070..677231) IV 1 NT_166523.1 Title: weak similarity to hypothetical precursor of mitochondrial ribosomal protein Yml15 - Saccharomyces cerevisiae [putative sequencing error]; mitochondrial 54S ribosomal protein mL57 677231 4981586 An07g03190 Aspergillus niger mitochondrial 54S ribosomal protein mL57 XP_059606658.1 675311 D 5061 CDS An07g03200 4981587 join(677443..677481,677557..677685,677854..678083,678148..678637,678709..678912,678997..679080,679205..679285) IV 1 NT_166523.1 Function: AP47 of M. musculus is the medium chain of the clathrin-associated protein complex AP-1, which leads to membrane protein selection and concentation by binding to its cytoplasmic tails.; Localization: AP47 of M. musculus is a component of the plasma membrane adaptor.; Remark: AP47 is also called AP1M1, clathrin coated assembly protein AP47, Golgi adaptor AP-1 47 kDa protein,HA1 47 kDa subunit, AP-MU chain family member MU1.; Remark: a second AP-47 2 chain of M. musculus was identified recently.; Title: strong similarity to adaptor complex AP-1 medium chain AP47 - Mus musculus; See PMID 10640811; uncharacterized protein 679285 4981587 An07g03200 Aspergillus niger uncharacterized protein XP_059606659.1 677443 D 5061 CDS An07g03210 4981588 complement(join(680391..681198,681271..681464)) IV 1 NT_166523.1 Function: Gtr1 of S. cerevisiae is associated with the function of the Pho84 inorganic phosphate transporter.; Function: ragA of H. sapiens, and its homologue Gtr1p of S. cerevisiae are G proteins, which are involved in the RCC1-Ran pathway.; Localization: ragA of H. sapiens was suggested to shuttle between the cytoplasm and the nucleus, depending on the bound nucleotide state.; Similarity: the ORF overlaps with A. niger EST an_3621 (EMBLEST:BE759269).; Title: strong similarity to ras-related GTPase ragA - Homo sapiens; See PMID 8886981; See PMID 9394008; See PMID 11073942; uncharacterized protein 681464 4981588 An07g03210 Aspergillus niger uncharacterized protein XP_001391404.1 680391 R 5061 CDS An07g03220 4981589 complement(join(682428..682511,682575..683167,683224..683714,683806..684143)) IV 1 NT_166523.1 Title: strong similarity to hypothetical conserved protein 3H10.120 - Neurospora crassa [putative sequncing errors]; uncharacterized protein 684143 4981589 An07g03220 Aspergillus niger uncharacterized protein XP_059606660.1 682428 R 5061 CDS An07g03230 84591328 join(684343..684429,684661..684729,684804..684875,685187..685285,685476..685536,685666..685729,685806..685925,686125..686211,686750..686872,686938..687126,687236..687307,687493..687551,687752..687845,687901..688168,688218..688271) IV 1 NT_166523.1 hypothetical protein 688271 84591328 An07g03230 Aspergillus niger hypothetical protein XP_059606661.1 684343 D 5061 CDS An07g03240 84591329 complement(join(688858..688915,689000..689093,689161..689245,689442..689717,689797..689839,689935..690076,690129..690234,690342..690387,690463..690512)) IV 1 NT_166523.1 hypothetical protein 690512 84591329 An07g03240 Aspergillus niger hypothetical protein XP_059606662.1 688858 R 5061 CDS An07g03250 4981592 join(691101..693689,693759..693860) IV 1 NT_166523.1 Title: similarity to hypothetical conserved protein B11N2.240 - Neurospora crassa; uncharacterized protein 693860 4981592 An07g03250 Aspergillus niger uncharacterized protein XP_001391408.1 691101 D 5061 CDS An07g03260 4981593 complement(join(694645..695355,695418..695819,695892..696122)) IV 1 NT_166523.1 Similarity: the ORF encoded protein shows similarity to a variety of hypothetical transporters and weak similarity to several known transporters. Additionally the ORF encoded protein contains two PFAM domains related to transport mechanisms.; Title: similarity to hypothetical protein B15I20.50 - Neurospora crassa; uncharacterized protein 696122 4981593 An07g03260 Aspergillus niger uncharacterized protein XP_001391409.3 694645 R 5061 CDS An07g03270 4981594 697104..697886 IV 1 NT_166523.1 Function: AADA6 of P. aeruginosa is able to confer high level resistance to streptomycin and spectinomycin.; Title: similarity to hypothetical aminoglycoside adenylyltransferase AADA6 - Pseudomonas aeruginosa; See PMID 10673049; uncharacterized protein 697886 4981594 An07g03270 Aspergillus niger uncharacterized protein XP_001391410.1 697104 D 5061 CDS An07g03280 4981595 complement(698699..700240) IV 1 NT_166523.1 Function: Gcd14p of S. cerevisiae is required for the biogenesis of tRNAiMet.; Title: similarity to tRNA Met processing protein Gcd14 - Saccharomyces cerevisiae; See PMID 10330157; uncharacterized protein 700240 4981595 An07g03280 Aspergillus niger uncharacterized protein XP_001391411.1 698699 R 5061 CDS An07g03290 4981596 join(701154..701196,701245..701327,701387..702115,702166..702309) IV 1 NT_166523.1 Catalytic activity: NADH specific Enoyl-[acyl-carrier protein] reductases convert acyl-[acyl-carrier protein] + NAD(+) to trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.; Complex: S. pneumoniae fabK contains a FAD-binding domain and is NADH specific.; Function: S. pneumoniae fabK is involved in fatty-acid biosynthesis and catalyses the reduction of enoyl-acyl-carrier-protein (ACP) during each cycle of fatty-acid elongation.; Title: strong similarity to trans-2-enoyl-ACP reductase II fabK - Streptococcus pneumoniae; See PMID 10910344; uncharacterized protein 702309 4981596 An07g03290 Aspergillus niger uncharacterized protein XP_001391412.1 701154 D 5061 CDS An07g03300 4981597 703249..704457 IV 1 NT_166523.1 Title: weak similarity to virion membrane glycoprotein BPRF1 - Murid herpesvirus 4; uncharacterized protein 704457 4981597 An07g03300 Aspergillus niger uncharacterized protein XP_001391413.3 703249 D 5061 CDS An07g03310 84591330 complement(join(706315..706594,706746..706855)) IV 1 NT_166523.1 hypothetical protein 706855 84591330 An07g03310 Aspergillus niger hypothetical protein XP_059606663.1 706315 R 5061 CDS An07g03320 4981599 707082..711908 IV 1 NT_166523.1 Function: Kinesins are ATPases specifically moving in the direction of the positive or negative end of microtubuli.; Title: similarity to kinesin light chain KLC -Plectonema boryanum; cytoskeleton; See PMID 9212172; See PMID 10754574; See PMID 11212346; uncharacterized protein 711908 4981599 An07g03320 Aspergillus niger uncharacterized protein XP_001391415.1 707082 D 5061 CDS An07g03330 4981600 complement(712258..713649) IV 1 NT_166523.1 Title: similarity to hypothetical protein CG12065 -Drosophila melanogaster; uncharacterized protein 713649 4981600 An07g03330 Aspergillus niger uncharacterized protein XP_059606664.1 712258 R 5061 CDS An07g03340 4981601 complement(join(715226..715282,715332..715420,715471..715813)) IV 1 NT_166523.1 Function: HYP1 of A. fumigatus is a cell wall protein regularly arranged in interwoven fascicules of clustered proteinaceous microfibrils, or rodlets, to form the outer spore coat protein. It is involved in resistance to environmental stress and may well be associated with conidial hydrophobicity. It is important in the morphogenesis of the dispersible conidia.; Remark: RODA is an alternative name for HYP1.; Similarity: belongs to the fungal hydrophobin family.; Title: strong similarity to hydrophobin hYP1 -Aspergillus fumigatus; See PMID 7927699; See PMID 7927700; uncharacterized protein 715813 4981601 An07g03340 Aspergillus niger uncharacterized protein XP_001391417.1 715226 R 5061 CDS An07g03350 84591331 join(716101..716183,716279..716326,716398..716720,716900..717219) IV 1 NT_166523.1 hypothetical protein 717219 84591331 An07g03350 Aspergillus niger hypothetical protein XP_059606665.1 716101 D 5061 CDS An07g03360 4981603 719289..720158 IV 1 NT_166523.1 Title: similarity to hypothetical proline-rich protein - Schizosaccharomyces pombe; uncharacterized protein 720158 4981603 An07g03360 Aspergillus niger uncharacterized protein XP_001391419.1 719289 D 5061 CDS An07g03370 4981604 join(720980..721193,721273..721718) IV 1 NT_166523.1 Function: YAR1 is required for normal rate of cell proliferation.; Title: similarity to ankyrin-like protein Yar1 -Saccharomyces cerevisiae; See PMID 8675027; uncharacterized protein 721718 4981604 An07g03370 Aspergillus niger uncharacterized protein XP_001391420.1 720980 D 5061 CDS An07g03380 4981605 complement(join(721899..723426,723573..723607)) IV 1 NT_166523.1 Catalytic activity: UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine.; Function: UGCG of M. musculus is a glucosyltransferase that transfers glucose to ceramide.; Localization: UGCG of M. musculus is an integral membrane protein in the endoplasmic reticulum.; Pathway: UGCG of M. musculus catalyzes the first glycosylation step of glycosphingolipid synthesis.; Title: similarity to UDP-glucose ceramide glucosyltransferase UGCG - Mus musculus; endoplasmatic reticulum; See PMID 9623774; See PMID 9918791; uncharacterized protein 723607 4981605 An07g03380 Aspergillus niger uncharacterized protein XP_059606666.1 721899 R 5061 CDS An07g03390 4981606 complement(724360..726042) IV 1 NT_166523.1 Title: similarity to hypothetical protein SPBC342.06c - Schizosaccharomyces pombe; uncharacterized protein 726042 4981606 An07g03390 Aspergillus niger uncharacterized protein XP_001391422.1 724360 R 5061 CDS An07g03400 84591332 complement(join(726483..726636,726730..726879,726965..727117,727206..727425,727516..727630)) IV 1 NT_166523.1 Title: weak similarity to cytoplasmic metalloproteinase mepB - Aspergillus fumigatus; uncharacterized protein 727630 84591332 An07g03400 Aspergillus niger uncharacterized protein XP_059606667.1 726483 R 5061 CDS An07g03410 4981608 complement(join(728213..728753,728822..728946,729001..729066,729128..729159,729228..729276,729359..729520)) IV 1 NT_166523.1 Title: similarity to hypothetical membrane protein YDL237w - Saccharomyces cerevisiae; uncharacterized protein 729520 4981608 An07g03410 Aspergillus niger uncharacterized protein XP_059606668.1 728213 R 5061 CDS An07g03420 4981609 complement(join(730162..730674,730731..731245,731294..731537,731590..731943,731996..732238,732300..732379,732449..733067,733137..733232)) IV 1 NT_166523.1 Title: similarity to hypothetical protein SPAC17A5.16 - Schizosaccharomyces pombe; uncharacterized protein 733232 4981609 An07g03420 Aspergillus niger uncharacterized protein XP_059606669.1 730162 R 5061 CDS An07g03430 4981610 complement(join(733726..734389,734457..734677)) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein CAD70902.1 - Neurospora crassa; uncharacterized protein 734677 4981610 An07g03430 Aspergillus niger uncharacterized protein XP_059606670.1 733726 R 5061 CDS An07g03440 4981611 join(735295..735835,735892..736280,736334..737002,737055..737150) IV 1 NT_166523.1 Title: similarity to hypothetical protein YHR045w -Saccharomyces cerevisiae; uncharacterized protein 737150 4981611 An07g03440 Aspergillus niger uncharacterized protein XP_001391427.1 735295 D 5061 CDS An07g03450 4981612 complement(join(737429..738411,738481..738583)) IV 1 NT_166523.1 hypothetical protein 738583 4981612 An07g03450 Aspergillus niger hypothetical protein XP_001391428.1 737429 R 5061 CDS An07g03460 4981613 join(738895..739105,739215..739590,739666..739774) IV 1 NT_166523.1 Function: IMG1 of s. cerevisiae is essential for respiration and maintenance of the mitochondrial genome.; Remark: PETCR46 and YCR046c are alternative names for IMG1 og s. cerevisiae.; Title: similarity to mitochondrial ribosomal protein Img1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8771712; mitochondrial 54S ribosomal protein bL19m 739774 4981613 An07g03460 Aspergillus niger mitochondrial 54S ribosomal protein bL19m XP_001391429.1 738895 D 5061 CDS An07g03470 4981614 complement(join(740089..740186,740220..740458,740518..740611,740668..740908,740960..741048,741103..741320,741377..741643,741696..741726,741777..741810,741861..741974,742038..742292)) IV 1 NT_166523.1 Expression: DAL5 is a constitutively expressed allantoin system gene whose product is required for allantoate transport in yeast.; Remark: dal5 mutants of S. cerevisiae lack allantoate transport; these mutant strains also exhibit a 60% loss of allantoin transport capability.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 2651902; See PMID 3275614; See PMID 3549700; uncharacterized protein 742292 4981614 An07g03470 Aspergillus niger uncharacterized protein XP_059606671.1 740089 R 5061 CDS An07g03480 84591333 complement(join(742384..742617,742715..742820,742907..742991,743185..743348,743416..743486)) IV 1 NT_166523.1 hypothetical protein 743486 84591333 An07g03480 Aspergillus niger hypothetical protein XP_059606672.1 742384 R 5061 CDS An07g03490 84591334 join(744488..744535,744851..744877,744956..745095,745157..745219,745285..745378,745431..745493) IV 1 NT_166523.1 hypothetical protein 745493 84591334 An07g03490 Aspergillus niger hypothetical protein XP_059606673.1 744488 D 5061 CDS An07g03500 84591335 join(745934..746323,746452..746619) IV 1 NT_166523.1 Title: weak similarity to hypothetical proline-rich protein - Schizosaccharomyces pombe; uncharacterized protein 746619 84591335 An07g03500 Aspergillus niger uncharacterized protein XP_059606674.1 745934 D 5061 CDS An07g03510 84591336 complement(join(746904..747077,747183..747267,747377..747468,747608..747735,747781..748053,748214..748271,748360..748468,748523..748587)) IV 1 NT_166523.1 hypothetical protein 748587 84591336 An07g03510 Aspergillus niger hypothetical protein XP_059606675.1 746904 R 5061 CDS An07g03520 4981619 join(748643..748729,748814..749098,749167..>749445) IV 1 NT_166523.1 Catalytic activity: pcbera reduces the benzylic ether functionalities of both dehydrodiconiferyl alcohol and dihydrodehydrodiconiferyl alcohol.; Remark: the ORF encoded protein is C-terminally truncated due to the contig border.; Title: similarity to phenylcoumaran benzylic ether reductase pcbera - Populus trichocarpa [truncated ORF]; See PMID 10066819; uncharacterized protein 749445 4981619 An07g03520 Aspergillus niger uncharacterized protein XP_001391435.3 748643 D 5061 CDS An07g03530 84591337 complement(749672..749878) IV 1 NT_166523.1 hypothetical protein 749878 84591337 An07g03530 Aspergillus niger hypothetical protein XP_059600898.1 749672 R 5061 CDS An07g03540 84591338 complement(join(750645..750997,751102..751126)) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein encoded by An02g00500 - Aspergillus niger; uncharacterized protein 751126 84591338 An07g03540 Aspergillus niger uncharacterized protein XP_059600899.1 750645 R 5061 CDS An07g03550 84591339 join(751773..751933,752026..752041) IV 1 NT_166523.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF; uncharacterized protein 752041 84591339 An07g03550 Aspergillus niger uncharacterized protein XP_059600900.1 751773 D 5061 CDS An07g03560 84591340 join(752077..752328,752583..752705) IV 1 NT_166523.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF; uncharacterized protein 752705 84591340 An07g03560 Aspergillus niger uncharacterized protein XP_059600901.1 752077 D 5061 CDS An07g03570 4981624 complement(join(752751..752998,753054..753437,753503..753752)) IV 1 NT_166523.1 Function: sou2 of C. albicans is required for L-sorbose assimilation.; Similarity: the ORF shows similarity to several short chain dehydrogenases/reductases from different species and with variuos substrate specificities.; Title: strong similarity to sorbitol utilization protein sou2 - Candida albicans; uncharacterized protein 753752 4981624 An07g03570 Aspergillus niger uncharacterized protein XP_001391440.1 752751 R 5061 CDS An07g03580 84591341 complement(join(754231..754509,754666..754703,754705..754873)) IV 1 NT_166523.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF; uncharacterized protein 754873 84591341 An07g03580 Aspergillus niger uncharacterized protein XP_059600902.1 754231 R 5061 CDS An07g03590 4981626 755340..757895 IV 1 NT_166523.1 Remark: the ORF shows similarity to several proline-rich or and serine-rich proteins.; hypothetical protein 757895 4981626 An07g03590 Aspergillus niger hypothetical protein XP_001391442.1 755340 D 5061 CDS An07g03600 4981627 complement(join(758016..758079,758486..758869,758947..759212)) IV 1 NT_166523.1 Function: chloride channels have several functions in the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport.; Phenotype: clc1 mutant mice (ADR) are a model for recessive autosomal myotonia, in addition to Cl-conductance, many other parameters are changed in muscles of homozygous animals.; Similarity: the ORF shows similarity to several choride channels from different species, which are involved in various cellular processes.; Similarity: the similarity to the chloride channel proteins starts around amino acid 50 of the ORF.; Title: similarity to chloride channel protein clc1 -Mus musculus; See PMID 1659665; uncharacterized protein 759212 4981627 An07g03600 Aspergillus niger uncharacterized protein XP_001391443.3 758016 R 5061 CDS An07g03610 4981628 complement(join(759803..760326,760377..760392)) IV 1 NT_166523.1 Title: similarity to hypothetical protein B13C5.110 - Neurospora crassa; uncharacterized protein 760392 4981628 An07g03610 Aspergillus niger uncharacterized protein XP_001391444.1 759803 R 5061 CDS An07g03620 4981629 join(761185..761302,761388..761719,761778..762035,762091..763001,763052..763115) IV 1 NT_166523.1 Induction: the mRNA of cnaA in A. nidulans varies in a cell cycle-dependent manner with maximal levels found early in G1 and considerably before the G1/S boundary.; Phenotype: gene disruption of cnaA in A. nidulans by homologous recombination leads to growth-arrest and reveals that the cells they are blocked early in the cell cycle.; Title: strong similarity to calcineurin chain cnaA -Aspergillus nidulans; See PMID 11289309; uncharacterized protein 763115 4981629 An07g03620 Aspergillus niger uncharacterized protein XP_001391445.1 761185 D 5061 CDS An07g03630 4981630 join(763630..763993,764067..764202,764267..765608) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein B11N2.220 - Neurospora crassa; uncharacterized protein 765608 4981630 An07g03630 Aspergillus niger uncharacterized protein XP_001391446.1 763630 D 5061 CDS An07g03640 84591342 join(766961..767030,767232..767376,767424..767462,767564..767642) IV 1 NT_166523.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF; uncharacterized protein 767642 84591342 An07g03640 Aspergillus niger uncharacterized protein XP_059605344.1 766961 D 5061 CDS An07g03650 84591343 join(768013..768085,768179..768229,768318..768484,768551..768628,768718..768932,769016..769074,769162..769208) IV 1 NT_166523.1 hypothetical protein 769208 84591343 An07g03650 Aspergillus niger hypothetical protein XP_059605345.1 768013 D 5061 CDS An07g03660 4981633 join(769337..769352,769485..769613,769684..769924,770196..770601) IV 1 NT_166523.1 Similarity: the ORF also overlaps with A. niger ESTs EMBLEST:BE759068, EMBLEST:BE75998, EMBLEST:BE760671 and EST SEQ ID NO:4064 from patent WO200056762-A2.; Similarity: the encoded protein also shows similarity to An09g00630.; Title: similarity to hypothetical protein CAD37045.1 - Neurospora crassa; uncharacterized protein 770601 4981633 An07g03660 Aspergillus niger uncharacterized protein XP_001391449.3 769337 D 5061 CDS An07g03670 4981634 join(771131..771144,771221..771275,771380..772824,772901..773093,773141..773314,773364..773453,773506..774453) IV 1 NT_166523.1 Function: syg1 of S. cerevisiae mediates response to, or transduces signals through, G-protein beta or G beta gamma, e. g. the mating pheromone-initiated signal.; Phenotype: the mutant SYG1 delta 340 in S. cerevisiae can suppress the cell cycle arrest associated with gpa1, but the cells retain a differentiated morphology.; Remark: syg1 of S. cerevisiae is also called YIL047C.; Remark: the ORF shows similarity to the xenotropic and polytropic murine retrovirus receptors of several mouse species.; Title: strong similarity to plasma membrane receptor Syg1 - Saccharomyces cerevisiae; plasma membrane; See PMID 7592711; uncharacterized protein 774453 4981634 An07g03670 Aspergillus niger uncharacterized protein XP_059605346.1 771131 D 5061 CDS An07g03680 4981635 join(774966..775118,775186..775256,775335..775929) IV 1 NT_166523.1 Function: qutR of A. nidulans is active in the signal-transduction pathway that regulates transcription of the quinic acid utilization (qut) gene cluster in A. nidulans.; Phenotype: mutations in the qutR gene of A. nidulans alter qutR function such that the transcription of the qut gene cluster is permanently on (constitutive phenotype) or is insensitive to the presence of quinate (super-repressed phenotype).; Title: strong similarity to repressor protein qutR -Aspergillus nidulans; See PMID 8704987; See PMID 10926843; uncharacterized protein 775929 4981635 An07g03680 Aspergillus niger uncharacterized protein XP_001391451.1 774966 D 5061 CDS An07g03690 4981636 complement(join(776767..777555,777622..777850,777901..778255,778330..778412,778491..778546)) IV 1 NT_166523.1 Function: ata1 of H. sapiens mediates Na+-dependent transport of system A neutral amino acids.; Induction: ata1 of H. sapiens is adaptively stimulated upon amino acid starvation of cultured human fibroblasts.; Similarity: the ORF shows similarity to several puatative membrane proteins/putative transporters from different species and with various function.; Title: strong similarity to amino acid transporter ata2 - Homo sapiens; See PMID 10930503; See PMID 11172802; uncharacterized protein 778546 4981636 An07g03690 Aspergillus niger uncharacterized protein XP_001391452.1 776767 R 5061 CDS An07g03710 4981637 780219..781493 IV 1 NT_166523.1 Remark: the ORF is questionable due to the presence of only a single long exon.; Title: questionable ORF; uncharacterized protein 781493 4981637 An07g03710 Aspergillus niger uncharacterized protein XP_001391453.1 780219 D 5061 CDS An07g03720 4981638 complement(join(781660..781689,781739..782263,782363..782610,782666..782717)) IV 1 NT_166523.1 Catalytic activity: NAD-dependent 15-hydroxyprostaglandin dehydrogenases catalyse (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD(+) <=> (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH.; Function: hpgd of R. norvegicus is involved in the reduction of prostaglandin E2, F2alpha and B1, but not of prostaglandin D2.; Title: strong similarity to NAD-dependent 15-hydroxyprostaglandin dehydrogenase hpgd - Rattus norvegicus; See PMID 9099857; uncharacterized protein 782717 4981638 An07g03720 Aspergillus niger uncharacterized protein XP_059605347.1 781660 R 5061 CDS An07g03730 4981639 join(783511..783711,783767..784936) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein ybiU - Escherichia coli; uncharacterized protein 784936 4981639 An07g03730 Aspergillus niger uncharacterized protein XP_059605348.1 783511 D 5061 CDS An07g03740 4981640 join(785396..785949,786011..788255,788340..788381) IV 1 NT_166523.1 Similarity: the ORF also shows strong similarity to the probable membrane protein YCL045c of S. cerevisiae.; Title: strong similarity to hypothetical protein SPAC25H1.07 - Schizosaccharomyces pombe; uncharacterized protein 788381 4981640 An07g03740 Aspergillus niger uncharacterized protein XP_001391456.1 785396 D 5061 CDS An07g03750 4981641 complement(join(789323..789835,789896..790276,790333..790474,790562..790824)) IV 1 NT_166523.1 Function: sec14 of Y. lipolytica is a phosphatidylglycerol/phosphatidylinositol transfer protein required for differentiation of the dimorphic yeast from the yeast to the mycelial form.; Remark: sec14 of Y. lipolytica is also called PI/PC TP.; Similarity: the predicted ORF is around 80 amino acoids longer at its C-terminal end than sec14 of several species, but 65 amino acids shorter than EC14 of Y. lipolytica.; Title: strong similarity to phosphatidylinositol-phosphatidylcholine transfer protein SEC14 - Yarrowia lipolytica; See PMID 11179668; uncharacterized protein 790824 4981641 An07g03750 Aspergillus niger uncharacterized protein XP_001391457.1 789323 R 5061 CDS An07g03760 4981642 complement(join(791424..793937,794162..794299)) IV 1 NT_166523.1 Function: snd1 of H. sapiens is as coactivator involved in gene transcription probably by interacting with TFIIE and other myb transcription factors.; Phenotype: H. sapiens snd1 overexpression specifically augmented EBNA 2 acidic domain-mediated activation of gene transcription.; Phenotype: snd1 of H. sapiens is essential for normal cell growth, since cell viability was reduced by antisense p100 RNA and restored by sense p100 RNA expression.; Title: strong similarity to 100 kDa coactivator snd1 - Homo sapiens; See PMID 7651391; See PMID 9003410; See PMID 9041650; See PMID 11124528; uncharacterized protein 794299 4981642 An07g03760 Aspergillus niger uncharacterized protein XP_001391458.1 791424 R 5061 CDS An07g03770 4981643 complement(join(795231..795253,795325..795421,795486..795817,796176..796188)) IV 1 NT_166523.1 Catalytic activity: superoxide dismutases convert 2 peroxide radical + 2 H(+) <=> O(2) + H(2)O(2).; Function: superoxide dismutases (SOD) are ubiquitous metalloproteins that prevent damage by oxygen-mediated free radicals by catalysing the dismutation of superoxide into molecular oxygen and hydrogen peroxide.; Repression: potassium cyanide and diethyldithiocarbamate, known Cu,Zn SOD inhibitors, caused inhibition of the purified sodC of A. fumigatus at working concentrations of 0. 25 mM, whilst sodium azide and o-phenanthroline demonstrated inhibition at higher concentrations (10-30 mM).; Similarity: the ORF overlaps with A. niger ESTs EMBLEST:BE759823, EMBLEST:BE76050 and EMBLEST:BE760712.; Title: strong similarity to Cu,Zn superoxide dismutase sodC - Aspergillus fumigatus; See PMID 7633574; uncharacterized protein 796188 4981643 An07g03770 Aspergillus niger uncharacterized protein XP_001391459.1 795231 R 5061 CDS An07g03780 84591344 complement(join(796678..796771,796858..796924,797075..797129,797214..797281,797400..797411,797496..797591,797816..798016,798071..798191,798263..798406,798516..798632)) IV 1 NT_166523.1 Remark: A. niger EST EMBLEST:AN741 shows weak similarity to the predicted ORF.; hypothetical protein 798632 84591344 An07g03780 Aspergillus niger hypothetical protein XP_059605349.1 796678 R 5061 CDS An07g03790 84591345 complement(join(798807..798930,799243..799341,799453..799499)) IV 1 NT_166523.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF; uncharacterized protein 799499 84591345 An07g03790 Aspergillus niger uncharacterized protein XP_059605350.1 798807 R 5061 CDS An07g03800 84591346 complement(join(799962..800223,800363..800466)) IV 1 NT_166523.1 hypothetical protein 800466 84591346 An07g03800 Aspergillus niger hypothetical protein XP_059605351.1 799962 R 5061 CDS An07g03810 84591347 join(802159..802204,802236..802339) IV 1 NT_166523.1 Catalytic activity: thymidylate synthases convert 5,10-methylenetetrahydrfolate + DUMP = dihydrofolate + DTMP.; Function: SPAC15E1. 04 of S. pombe is involved in deoxyribonucleotide biosynthesis.; Remark: the prediction of the ORF structure is questionable, as its lenght is only 49 amino acids.; Title: weak similarity to hypothetical thymidylate synthase-like DNA metabolism protein SPAC15E1.04 -Schizosaccharomyces pombe; uncharacterized protein 802339 84591347 An07g03810 Aspergillus niger uncharacterized protein XP_059605352.1 802159 D 5061 CDS An07g03820 84591348 complement(join(803293..803300,803418..803619)) IV 1 NT_166523.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF; uncharacterized protein 803619 84591348 An07g03820 Aspergillus niger uncharacterized protein XP_059605353.1 803293 R 5061 CDS An07g03830 84591349 join(805511..805656,805758..805938,806047..806181) IV 1 NT_166523.1 Function: panB of A. nidulans is part of an alkaline ambient pH signal transduction pathway, which senses ambient pH and transduces a signal to trigger the transcription factor PacC processing.; Function: the panB regulated protein pacC of A. nidulans is a zinc finger transcriptional regulator, which is, at alkaline ambient pH, proteolytically processed to a functional form serving as an activator of alkaline-expressed genes and a repressor of acid-expressed genes.; Similarity: the predicted ORF is 700 amino acids shorter than the calpain-like protease PalBory from A. oryzae and the similarity is only high in its C-terminus starting with amino acid 108.; Similarity: the similarity of the ORF to the palB protein of A. nidulans is restricted to a structural domain of calpain-related proteins with unknown function (domain III).; Title: weak similarity to calpain-like cysteine protease palB - Aspergillus nidulans; uncharacterized protein 806181 84591349 An07g03830 Aspergillus niger uncharacterized protein XP_059605354.1 805511 D 5061 CDS An07g03840 84591350 join(806237..806251,806426..806512,806760..806843,806928..807079,807157..807232,807344..807442) IV 1 NT_166523.1 hypothetical protein 807442 84591350 An07g03840 Aspergillus niger hypothetical protein XP_059605355.1 806237 D 5061 CDS An07g03850 4981651 complement(join(807599..807835,807891..808274,808341..808655,808735..808773)) IV 1 NT_166523.1 Catalytic activity: tal1 of S. cerevisiae catalyses sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate.; Function: tal1 of S. cerevisiae is important for the balance of metabolites in the pentose-phosphate pathway.; Phenotype: tal1 transaldolase-deficient S. cerevisiae strains accumulated sedoheptulose 7-phosphate,an intermediate of the pentose-phosphate pathway.; Remark: tal1 of S. cerevisiae is also called L9638. 6 or YLR354c.; Similarity: the ORF overlaps with A. niger ESTs EMBLEST:BE760370 and EMBLEST:BE759174.; Title: strong similarity to transaldolase Tal1 -Saccharomyces cerevisiae; cytoplasm; uncharacterized protein 808773 4981651 An07g03850 Aspergillus niger uncharacterized protein XP_001391467.1 807599 R 5061 CDS An07g03860 4981652 complement(join(810022..810051,810115..810279,810340..810552,810615..810920,810988..811142,811217..815137,815243..815413,815476..817966)) IV 1 NT_166523.1 Protein sequence is in conflict with the conceptual translation; Function: lvsA (volume sphere A) of D. discoideum has an important role in a membrane-processing pathway that is essential for cytokinesis, probable by regulating lysosomal membrane traffic, as it shows homology to the beige protein.; Similarity: the ORF overlaps with A. niger EST an_3046, EMBLEST:BE758802.; Similarity: the predicted ORF is 1107 amino acid shorter at its N-terminus than lvsA of D. discoideum.; Title: strong similarity to beige protein homolog lvsA - Dictyostelium discoideum [putative sequencing error]; putative sequencing error; See PMID 10588668; uncharacterized protein 817966 4981652 An07g03860 Aspergillus niger uncharacterized protein XP_059605356.1 810022 R 5061 CDS An07g03870 84591351 join(820029..820105,820303..820579) IV 1 NT_166523.1 Remark: the ORF has an intron-exon structure, which is not typical for A. niger proteins and is only 117 amino acids long.; Title: questionable ORF; uncharacterized protein 820579 84591351 An07g03870 Aspergillus niger uncharacterized protein XP_059605357.1 820029 D 5061 CDS An07g03880 4981654 join(821957..822325,822396..823331,823388..823576) IV 1 NT_166523.1 Gene-ID: pepC; Mapping: pepC from A. niger is mapped to chromosome IV (LG IV); see list from DSM, PUBMED 9309173.; Remark: the proposed gene model of pepC from A. niger differs from the published sequence because an additional intron was introduced (based on cDNA data). This new model has higher homology with the P. citrinum alkaline serine protease Pen c2.; Similarity: the ORF overlaps with A. niger EST an_3439 (EMBLEST:BE759117), the sequence for A. niger subtilisin-like serine protease pepC (EMBL:ANPEPC) and patent AU9336959-A decribing the subtilisin-like serine protease PEPC from A. niger (PATENTDNA:AAQ52535).; Similarity: the predicted ORF varies from the protein sequence of PATENTPROT:AAR44433 and PIR JU0146 in the two positions S398P and R525L.; serine proteinase pepC-Aspergillus niger 823576 pepC 4981654 pepC Aspergillus niger serine proteinase pepC-Aspergillus niger XP_001391470.1 821957 D 5061 CDS An07g03890 4981655 complement(join(824465..824964,825097..825298,825346..825411)) IV 1 NT_166523.1 Catalytic activity: S. cerevisiae cdc34 catalyses ATP + ubiquitin + protein lysine = AMP + pyrophosphate + protein N-ubiquityllysine.; Function: S. cerevisiae cdc34 catalyzes the covalent attachment of ubiquitin to several protein, which finally leads to degradation by the proteasome.; Phenotype: mutants in the gene CDC34 of S. cerevisiae are defective in the transition from G1 to the S phase of the cell cycle, a process, which is also controlled by the degradation of cyclin-dependent kinases.; Remark: cdc34 of S. cerevisiae is also called ubc3,DNA6 or YDR054C.; Remark: the ORF overlaps with database entries containing the 3' untranslated region of pepC from A. niger, which is encoded on ORF 30WK.; Title: strong similarity to ubiquitin conjugating enzyme Cdc34 - Saccharomyces cerevisiae; See PMID 8939846; See PMID 10975521; uncharacterized protein 825411 4981655 An07g03890 Aspergillus niger uncharacterized protein XP_059605358.1 824465 R 5061 CDS An07g03900 84591352 complement(join(826041..826132,826189..826288,826567..826611)) IV 1 NT_166523.1 Remark: the ORF has an intron-exon structure, which is not typical for A. niger proteins and is only 78 amino acids long.; Title: questionable ORF; uncharacterized protein 826611 84591352 An07g03900 Aspergillus niger uncharacterized protein XP_059605359.1 826041 R 5061 CDS An07g03910 84591353 join(826901..826984,827072..827182,827311..827658) IV 1 NT_166523.1 Remark: the ORF has a suboptimal intron-exon structure.; Title: questionable ORF; uncharacterized protein 827658 84591353 An07g03910 Aspergillus niger uncharacterized protein XP_059605360.1 826901 D 5061 CDS An07g03920 4981658 join(827795..827859,827937..829066,829127..832863) IV 1 NT_166523.1 Function: bile acid transport essentially takes place out of mammalian hepatocytes into the bile.; Remark: YBT1 of S. cerevisiae is also called BAT1 or YLL048.; Similarity: the ORF shows strong similarity to several ABC-transporters from different species and with various substrate specificities.; Title: strong similarity to bile acid transporter Ybt1 - Saccharomyces cerevisiae; uncharacterized protein 832863 4981658 An07g03920 Aspergillus niger uncharacterized protein XP_059605361.1 827795 D 5061 CDS An07g03930 4981659 join(834417..835132,835457..835603,835659..835662) IV 1 NT_166523.1 Remark: the intron-exon structure is suboptimal.; hypothetical protein 835662 4981659 An07g03930 Aspergillus niger hypothetical protein XP_001391475.3 834417 D 5061 CDS An07g03940 4981660 complement(join(835856..836082,836154..836569,836650..837685,837750..838040,838093..838527,838635..838845,838966..839043)) IV 1 NT_166523.1 Function: the amdA transcriptional activator from A . nidulans is involved in the induction of the A. nidulans structual gene amdS (acetamidase), i. e. mediates acetate induction.; Phenotype: semi-dominant mutations in the amdA gene of A. nidulans lead to elevated expression of the gene encoding acetamidase amdS.; Similarity: the ORF shows homology to several DNA binding regulatory proteins.; Title: strong similarity to zinc-finger transcription factor amdA - Aspergillus nidulans; See PMID 8119589; See PMID 9126617; uncharacterized protein 839043 4981660 An07g03940 Aspergillus niger uncharacterized protein XP_059605362.1 835856 R 5061 CDS An07g03950 4981661 join(839165..839222,839286..839741,839817..840112) IV 1 NT_166523.1 Function: Clkr27 of C. lanceolata is an integral part of the fatty acid synthase type II, which is involved in fatty acid biosynthesis.; Similarity: the ORF shows similarity to several oxidoreductases from different species with various cellular activities.; Title: strong similarity to beta-ketoacyl-ACP reductase Clkr27 - Cuphea lanceolata; uncharacterized protein 840112 4981661 An07g03950 Aspergillus niger uncharacterized protein XP_001391477.1 839165 D 5061 CDS An07g03960 4981662 complement(join(840382..841319,841375..841997,842073..842101)) IV 1 NT_166523.1 Catalytic activity: amidases catalyse a monocarboxylic acid amide + H(2)O <=> a monocarboxylate + NH(3).; Similarity: the ORF shows strong similarity to amidases from several species.; Title: strong similarity to amidase - Rhodococcus sp.; See PMID 2001397; uncharacterized protein 842101 4981662 An07g03960 Aspergillus niger uncharacterized protein XP_001391478.1 840382 R 5061 CDS An07g03970 4981663 join(842758..842947,843004..843433,843488..844286) IV 1 NT_166523.1 Remark: the gene product of the mtr locus of N. crassa is required for the transport of neutral aliphatic and aromatic amino acids via the N system.; Title: strong similarity to neutral amino acid permease mtr - Neurospora crassa; uncharacterized protein 844286 4981663 An07g03970 Aspergillus niger uncharacterized protein XP_001391479.1 842758 D 5061 CDS An07g03980 4981664 complement(join(845335..845527,845578..845761,845831..845909,845961..846317,846368..846467,846534..846577,846632..846761,846845..846892,846948..847003)) IV 1 NT_166523.1 Function: OSM1 of P. grisea is involved in controlling the response to hyperosmotic stress by regulating cellular turgor.; Induction: exposure of M. grisea appressoria to external hyperosmotic stress induced OSM1-dependent production of arabitol, which acts as the major compatible solute to accumulating glycerol.; Phenotype: M. grisea delta OSM1 mutants showed a dramatically reduced ability to accumulate arabitol in the mycelium.; Title: strong similarity to osmotic sensitivity MAP Kinase OSM1 - Pyricularia grisea; See PMID 10521531; uncharacterized protein 847003 4981664 An07g03980 Aspergillus niger uncharacterized protein XP_001391480.1 845335 R 5061 CDS An07g03990 4981665 complement(join(847670..847766,847828..847948,847984..848092,848240..848504,848666..848759,848826..850837,850910..851268,851329..851715)) IV 1 NT_166523.1 Function: SPCC1739. 03 of S. pombe is possibly involved in the decay of mRNA containing nonsense codons.; Similarity: the ORF overlaps with A. niger ESTs Nig022 (EMBLEST:AN74) and Nig022c (EMBLEST:AN742).; Title: strong similarity to hypothetical ATP binding protein SPCC1739.03 - Schizosaccharomyces pombe; uncharacterized protein 851715 4981665 An07g03990 Aspergillus niger uncharacterized protein XP_059605363.1 847670 R 5061 CDS An07g04000 4981666 join(853160..853199,853262..854071,854372..854918,854986..855208) IV 1 NT_166523.1 Function: SPT8 of S. cerevisiae is a member of the yeast SAGA complex, in which SPT8 is required for TBP function at particular promoters probably by promoting a functional interaction between SPT3 and TBP.; Phenotype: mutations in SPT8 of S. cerevisiae confer phenotypes similar to those caused by particular mutations in SPT15, which encodes the TATA-binding protein (TBP).; Similarity: due to the presence of a WD-repeat motive, the ORF shows homology to beta transducin-like proteins, which is a subunit of G-proteins.; Title: strong similarity to transcription factor Spt8 - Saccharomyces cerevisiae; See PMID 8088510; See PMID 10101163; See PMID 10611242; uncharacterized protein 855208 4981666 An07g04000 Aspergillus niger uncharacterized protein XP_059605364.1 853160 D 5061 CDS An07g04010 4981667 complement(855718..856779) IV 1 NT_166523.1 hypothetical protein 856779 4981667 An07g04010 Aspergillus niger hypothetical protein XP_001391483.1 855718 R 5061 CDS An07g04020 4981668 join(857201..857490,857561..857871,857927..858267,858325..858660) IV 1 NT_166523.1 Function: SKY1 of S. cerevisiae is regulating the targeting of serine/arginine-rich pre-mRNA splicing factors.; Phenotype: S. cerevisiae SKY1 mutants shows slow growth and decreased in vivo phosphorylation of the shuttling protein NPl3.; Similarity: the ORF is 317 amino acids shorter than SKY1 of S. cerevisiae; Similarity: the ORF shows similarity to several protein kinases with different cellular functions.; Title: strong similarity to protein kinase Sky1 -Saccharomyces cerevisiae; See PMID 10225947; See PMID 10318902; See PMID 11113192; uncharacterized protein 858660 4981668 An07g04020 Aspergillus niger uncharacterized protein XP_059605365.1 857201 D 5061 CDS An07g04030 4981669 join(859005..859758,859855..860070,860164..860198) IV 1 NT_166523.1 Similarity: the hypothetical protein SPBC19C2. 08 of S. pombe is 124 amino acid shorter than the predicted ORF.; Title: strong similarity to hypothetical protein SPBC19C2.08 - Schizosaccharomyces pombe; uncharacterized protein 860198 4981669 An07g04030 Aspergillus niger uncharacterized protein XP_001391485.3 859005 D 5061 CDS An07g04040 4981670 complement(join(860275..860755,860812..861277,861346..861862)) IV 1 NT_166523.1 Similarity: the similarity of the ORF to the putative protein mlr7324 of M. loti is restricted to the second half of the ORF.; Title: similarity to hypothetical protein mlr7324 -Mesorhizobium loti; uncharacterized protein 861862 4981670 An07g04040 Aspergillus niger uncharacterized protein XP_001391486.1 860275 R 5061 CDS An07g04050 84591354 complement(join(862061..862120,862217..862315,862421..862581,862721..862796,862880..862966)) IV 1 NT_166523.1 hypothetical protein 862966 84591354 An07g04050 Aspergillus niger hypothetical protein XP_059605366.1 862061 R 5061 CDS An07g04060 84591355 join(863500..863626,863741..864034,864093..864296,864349..864545) IV 1 NT_166523.1 Remark: the A. niger patent WO200056762-A2has database entry number PATENTDNA:AAF11789 SEQ ID NO:4312.; Title: strong similarity to EST SEQ ID NO:4312 from patent WO200056762-A2 - Aspergillus niger; uncharacterized protein 864545 84591355 An07g04060 Aspergillus niger uncharacterized protein XP_059605367.1 863500 D 5061 CDS An07g04070 4981673 complement(join(864827..864844,864900..865427,865680..865951,866001..866124)) IV 1 NT_166523.1 Function: WSC4 of S. cerevisiae is believed to be involved in RHO protein signal transduction, cell wall organization and biogenesis, and heat shock response.; Remark: WSC4 of S. cerevisiae is also called YHC8 or YHL028W.; Similarity: the similarity of the predicted ORF to WSC4 of S. cerevisiae is restricted to its N-terminal half (ending with amino acid 194) and the ORF is 292 amino acids shorter.; Title: similarity to stress response receptor Wsc4 -Saccharomyces cerevisiae; uncharacterized protein 866124 4981673 An07g04070 Aspergillus niger uncharacterized protein XP_001391489.1 864827 R 5061 CDS An07g04080 84591356 join(866883..867093,867433..867815) IV 1 NT_166523.1 Remark: the predicted ORF contains on unusually long intron.; Title: questionable ORF; uncharacterized protein 867815 84591356 An07g04080 Aspergillus niger uncharacterized protein XP_059605368.1 866883 D 5061 CDS An07g04090 84591357 join(868153..868490,868683..868780,868885..868939,869380..869563) IV 1 NT_166523.1 Remark: the patent WO200056762-A2 is found in PATENTDNA:AAF11704 SEQ ID NO:4227.; Title: similarity to EST SEQ ID NO:4227 from patent WO200056762-A2 - Aspergillus niger; uncharacterized protein 869563 84591357 An07g04090 Aspergillus niger uncharacterized protein XP_059605369.1 868153 D 5061 CDS An07g04100 84591358 complement(join(869712..869828,870022..870090,870194..870289)) IV 1 NT_166523.1 Similarity: shares local similarity with a N-terminally located domain of fatty acid amide hydrolase from Rattus norvegicus.; hypothetical protein 870289 84591358 An07g04100 Aspergillus niger hypothetical protein XP_059605370.1 869712 R 5061 CDS An07g04110 84591359 join(870763..870924,871029..871211) IV 1 NT_166523.1 Similarity: shows local similarity to a highly conserved domain of mammalian RAG2 proteins.; Title: weak similarity to hypothetical recombination activating protein 2 RAG2 - Pteropus giganteus; uncharacterized protein 871211 84591359 An07g04110 Aspergillus niger uncharacterized protein XP_059605371.1 870763 D 5061 CDS An07g04120 4981678 complement(join(872823..873098,873239..873731,873784..873859,873918..874791)) IV 1 NT_166523.1 Similarity: a blast search produces multiple randomly distributed matches to diverse Arg/Glu- and Pro-rich proteins.; hypothetical protein 874791 4981678 An07g04120 Aspergillus niger hypothetical protein XP_059605372.1 872823 R 5061 CDS An07g04130 4981679 complement(875693..877705) IV 1 NT_166523.1 Function: Rad30 of S. cerevisiae is capable of error-free replication of UV-damaged DNA.; Function: Rad30 of S. cerevisiae transgresses cis-syn T-T dimers which normally block DNA replication progress and incorporates two adenines in the daughter strand.; Remark: possible sequencing error at position 51965 altering the intron donor GT to GA, alternatively this might be a rare splice site or the ORF might indeed be unspliced (the annotated intron is in frame).; Remark: the C-terminal third of Eso1 of S. pombe is homologous to and shares the function of the sister chromatid cohesion establishment protein Eco1 of S. cerevisiae.; Remark: the N-terminal two thirds of Eso1 of S. pombe are homologous to and share the function of DNA polymerase eta (Rad30) of S. cerevisiae which is involved in cis-syn T-T dimer translesion DNA synthesis.; Similarity: the A. niger ORF also shows strong similarity to DNA polymerase eta (Rad30) of S. cerevisiae (sytematic gene name YDR419w).; Similarity: the A. niger ORF shows similarity only to the N-terminal two thirds of Eso1 of S. pombe which are homologous to DNA polymerase eta (Rad30) of S. cerevisiae.; Title: strong similarity to sister chromatid cohesion protein eso1p - Schizosaccharomyces pombe [putative sequencing error]; See PMID 9974380; See PMID 10601233; See PMID 10779336; uncharacterized protein 877705 4981679 An07g04130 Aspergillus niger uncharacterized protein XP_001391495.1 875693 R 5061 CDS An07g04140 84591360 join(878361..878536,878652..878888,878969..879075,879183..879279,879553..879733,879809..879909,880028..880114,880222..880277,880361..880382,880474..880581,880637..880704,880832..880986) IV 1 NT_166523.1 hypothetical protein 880986 84591360 An07g04140 Aspergillus niger hypothetical protein XP_059605373.1 878361 D 5061 CDS An07g04147 84591361 join(881223..881434,881719..882409) IV 1 NT_166523.1 Remark: the EST sequence matches the complementary strand.; Title: similarity to EST an_1643 - Aspergillus niger; uncharacterized protein 882409 84591361 An07g04147 Aspergillus niger uncharacterized protein XP_059605374.1 881223 D 5061 CDS An07g04160 4981682 join(882695..882820,882958..883002,883038..883745) IV 1 NT_166523.1 Similarity: the blastp produces a staggering amount of random hits against diverse proline-rich (eg expansin-like) proteins.; Title: strong similarity to FLO11 gene expression regulator An34 from patent WO200257456-A2 - Unclassified organism; uncharacterized protein 883745 4981682 An07g04160 Aspergillus niger uncharacterized protein XP_059605375.1 882695 D 5061 CDS An07g04170 4981683 join(885199..885361,885447..886831) IV 1 NT_166523.1 Remark: the cDNA encoding LckSH3 domain-combining protein is patented under PATENTDNA:X40398.; Title: weak similarity to LckSH3 domain-combining protein from patent JP11080196-A - Homo sapiens; uncharacterized protein 886831 4981683 An07g04170 Aspergillus niger uncharacterized protein XP_059605376.1 885199 D 5061 CDS An07g04180 4981684 complement(join(887551..887597,887698..887881)) IV 1 NT_166523.1 Catalytic activity: NADH + H(+) + ubiquinone = NAD(+) + ubiquinol.; Complex: complex I is composed of about 40 different subunits.; Function: complex I of N. crassa transfers electrons from NADH to the respiratory chain (ubiquinone).; Function: the 9. 5 kD subunit of complex I of N. crassa binds ubiquinone.; Similarity: the CDS is identical to the A. niger EST sequence from the DNA patent PATENTDNA:F11443 (Aspergillus niger EST SEQ ID NO:3966).; Title: strong similarity to 9.5 kD subunit of NADH:ubiquinone reductase - Neurospora crassa; localisation:mitochondrion; See PMID 1445878; See PMID 1445879; uncharacterized protein 887881 4981684 An07g04180 Aspergillus niger uncharacterized protein XP_001391500.1 887551 R 5061 CDS An07g04190 4981685 join(888310..888451,888519..888629,888694..889397,889460..889879) IV 1 NT_166523.1 Catalytic activity: dolichyl diphosphooligosaccharide + protein L-Asn = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-Asn.; Complex: DDOST of G. gallus is an heterotrimeric complex of a 67kD (ribophorin I), a 63/64 kD (ribophorin II) and a 48 kD subunit.; Function: N-oligosaccharyl transferase catalyses the transfer of a high-mannose oligosaccharide from a lipid-linked oligosaccharide donor onto asparagine acceptor sites within an Asn-X-Ser/Thr consensus motif in newly synthesized proteins.; Function: the 48kD chain constitutes an essential subunit of N-oligosaccharyl transferase of G. gallus.; Remark: an alternative name for DDOST is N-oligosaccharyltransferase.; Title: strong similarity to dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48kD chain DDOST - Gallus gallus; endoplasmatic reticulum; See PMID 8175777; uncharacterized protein 889879 4981685 An07g04190 Aspergillus niger uncharacterized protein XP_001391501.1 888310 D 5061 CDS An07g04200 4981686 join(891174..891288,891354..892651) IV 1 NT_166523.1 Catalytic activity: triacylglycerol + H2O = diacylglycerol + a fatty acid anion.; Localization: triacylglycerol lipase of C. familiaris is secreted.; Title: strong similarity to precursor of triacylglycerol lipase - Canis lupus; extracellular/secretion proteins; See PMID 10520456; See PMID 1935982; uncharacterized protein 892651 4981686 An07g04200 Aspergillus niger uncharacterized protein XP_001391502.1 891174 D 5061 CDS An07g04210 84591362 complement(join(892689..892754,892891..893196,893244..893399)) IV 1 NT_166523.1 hypothetical protein 893399 84591362 An07g04210 Aspergillus niger hypothetical protein XP_059605377.1 892689 R 5061 CDS An07g04220 84591363 join(893596..893708,893755..893790,893869..893999,894085..894257,894455..894478,894534..894596) IV 1 NT_166523.1 hypothetical protein 894596 84591363 An07g04220 Aspergillus niger hypothetical protein XP_059605378.1 893596 D 5061 CDS An07g04230 84591364 join(894718..894736,894765..894778,894840..895038,895129..895418) IV 1 NT_166523.1 Title: weak similarity to outer membrane protein from patent WO9640893-A1 - Helicobacter pylori; uncharacterized protein 895418 84591364 An07g04230 Aspergillus niger uncharacterized protein XP_059605379.1 894718 D 5061 CDS An07g04240 4981690 join(895982..895992,896074..896105,896179..896205,896267..896346,896395..896417,896500..896528,896585..896594,896697..897120) IV 1 NT_166523.1 Function: krev-1 of N. crassa is probably involved in the regulation of sexual cycle progression.; Phenotype: overexpression of krev-1 from N. crassa in S. cerevisiae resulted in a random budding pattern.; Similarity: belongs to the ras superfamily of small GTPases.; Title: strong similarity to low-molecular-weight GTP/GDP-binding protein krev-1 - Neurospora crassa; See PMID 9267439; uncharacterized protein 897120 4981690 An07g04240 Aspergillus niger uncharacterized protein XP_001391506.1 895982 D 5061 CDS An07g04250 4981691 complement(join(898181..898215,898285..898310,898343..898770,898818..899095,899192..899585)) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein encoded by An05g02120 - Aspergillus niger; uncharacterized protein 899585 4981691 An07g04250 Aspergillus niger uncharacterized protein XP_059605380.1 898181 R 5061 CDS An07g04260 4981692 complement(join(900030..900167,900248..900379,900448..901370,901441..901543,901596..901655)) IV 1 NT_166523.1 Catalytic activity: acetyl-CoA + acetoacetyl-CoA + H2O = (S)-3-hydroxy-3-methyglutaryl-CoA + CoA-SH.; Function: HMGS of S. cerevisiae condenses acetyl-CoA with acetoacetyl-CoA to form hydroxymethylglutaryl-CoA,which is the substrate for HMG-CoA reductase leading to mevalonate.; Pathway: HMGS of S. cerevisiae is involved in the ergosterol biosynthesis pathway.; Remark: an alternative name for HMGS is ERG13.; Title: strong similarity to 3-hydroxy-3-methylglutaryl-CoA synthase Erg13 -Saccharomyces cerevisiae; See PMID 6148937; See PMID 9784867; uncharacterized protein 901655 4981692 An07g04260 Aspergillus niger uncharacterized protein XP_001391508.1 900030 R 5061 CDS An07g04270 4981693 complement(join(902818..903112,903170..904611)) IV 1 NT_166523.1 Catalytic activity: MCC of H. sapiens converts 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA utilizing bicarbonate.; Catalytic activity: the carboxylation of 3-methylcrotonyl-CoA is energy-driven by the hydrolysis of ATP to ADP and phosphate.; Complex: MCCB of H. sapiens forms part of MCC consisting of one alpha and several beta subunits.; Pathway: MCC of H. sapiens catalyses a critical step in the leucine degradation pathway.; Title: strong similarity to 3-methylcrotonyl-CoA carboxylase (MCC) non-biotin-containing beta subunit MCCB -Homo sapiens; localisation:mitochondrion; See PMID 11170888; See PMID 11181649; See PMID 11406611; uncharacterized protein 904611 4981693 An07g04270 Aspergillus niger uncharacterized protein XP_001391509.1 902818 R 5061 CDS An07g04280 4981694 join(905038..905221,905282..905369,905422..905516,905574..905809,905884..906161,906225..906639) IV 1 NT_166523.1 Catalytic activity: AtIVD activity requires FAD as a cofactor.; Catalytic activity: AtIVD of A. thaliana catalyzes the conversion of isovaleryl-CoA to 3-methylcrotonyl-CoA.; Complex: AtIVD of A. thaliana probably forms a homodimer.; Function: AtIVD of A. thaliana is also able to metabolize the valine degradation intermediate isobutyryl-CoA.; Function: the electrons from the substrate are transferred via ETF (electron-transferring flavoprotein) and ETF-dehydrogenase to ubiquinol.; Pathway: AtIVD of A. thaliana catalyzes an intermediate step in the leucine degradation pathway.; Title: strong similarity to isovaleryl-coenzyme A dehydrogenase AtIVD - Arabidopsis thaliana; localisation:mitochondrion; See PMID 11402190; uncharacterized protein 906639 4981694 An07g04280 Aspergillus niger uncharacterized protein XP_001391510.1 905038 D 5061 CDS An07g04290 4981695 complement(join(906805..907674,907774..907851)) IV 1 NT_166523.1 Function: MARCKS of patent Y95899 is involved in the regulation of mucus secretion.; Similarity: other matches with bettter expect values were rejected due to length incongruency.; Similarity: weakly homologous to protein of patent database entry PATENTPROT:Y95899.; Title: weak similarity to myristoylated alanine-rich C kinase substrate MARCKS from patent WO200050062-A2 -Homo sapiens; uncharacterized protein 907851 4981695 An07g04290 Aspergillus niger uncharacterized protein XP_001391511.1 906805 R 5061 CDS An07g04300 4981696 join(908365..908519,908599..908797,908856..908953,909001..910624,910856..910909) IV 1 NT_166523.1 Catalytic activity: MCC of H. sapiens converts 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA utilizing bicarbonate.; Catalytic activity: the carboxylation of 3-methylcrotonyl-CoA is energy-driven by the hydrolysis of ATP to ADP and phosphate.; Complex: MCCA of H. sapiens forms part of MCC consisting of one alpha and several beta subunits.; Function: MCCA of H. sapiens binds biotin.; Pathway: MCC of H. sapiens catalyses a critical step in the leucine degradation pathway.; Title: strong similarity to 3-methylcrotonyl-CoA carboxylase (MCC) biotin-containing alpha subunit MCCA -Homo sapiens; localisation:mitochondrion; See PMID 11170888; See PMID 11181649; See PMID 11401427; See PMID 11406611; uncharacterized protein 910909 4981696 An07g04300 Aspergillus niger uncharacterized protein XP_001391512.1 908365 D 5061 CDS An07g04310 84591365 complement(join(911932..912075,912131..912258,912340..912445)) IV 1 NT_166523.1 hypothetical protein 912445 84591365 An07g04310 Aspergillus niger hypothetical protein XP_059605381.1 911932 R 5061 CDS An07g04320 4981698 join(913028..913205,913259..913334,913387..913812,913861..914041) IV 1 NT_166523.1 Catalytic activity: D-arabinitol + NAD(+) = D-ribulose + NADH(+).; Title: strong similarity to NAD-dependent D-arabinitol dehydrogenase ard - Candida tropicalis; See PMID 7698655; uncharacterized protein 914041 4981698 An07g04320 Aspergillus niger uncharacterized protein XP_001391514.3 913028 D 5061 CDS An07g04330 84591366 complement(915384..918113) IV 1 NT_166523.1 Function: het-6 of N. crassa is involved in the restriction of heterokaryon formation during asexual growth.; Remark: in filamentous fungi, vegetative cell fusion between genotypically distinct individuals leads to a cell-death reaction known as vegetative or heterokaryon incompatibility.; Similarity: het-6(OR) of N. crassa has three regions of amino acid sequence similarity to the predicted product of the het-e vegetative incompatibility gene in P. anserina and to the predicted product of tol, which mediates mating-type vegetative incompatibility in N. crassa.; Title: similarity to heterokaryon incompatibility protein het-6 - Neurospora crassa; See PMID 10880472; See PMID 11035941; See PMID 11092825; uncharacterized protein 918113 84591366 An07g04330 Aspergillus niger uncharacterized protein XP_059605382.1 915384 R 5061 CDS An07g04340 4981699 complement(join(918302..918483,918608..919448,919556..919705,919746..919880,919966..920028)) IV 1 NT_166523.1 hypothetical protein 920028 4981699 An07g04340 Aspergillus niger hypothetical protein XP_059605383.1 918302 R 5061 CDS An07g04350 4981701 join(920291..921268,921313..921498) IV 1 NT_166523.1 hypothetical protein 921498 4981701 An07g04350 Aspergillus niger hypothetical protein XP_059605384.1 920291 D 5061 CDS An07g04360 84591367 complement(join(922076..922119,922187..922262,922344..922428,922976..925073,925130..925193)) IV 1 NT_166523.1 hypothetical protein 925193 84591367 An07g04360 Aspergillus niger hypothetical protein XP_059605385.1 922076 R 5061 CDS An07g04370 84591368 complement(join(925280..925301,925343..925435,925574..925731,925813..925871,925987..926074)) IV 1 NT_166523.1 hypothetical protein 926074 84591368 An07g04370 Aspergillus niger hypothetical protein XP_059605386.1 925280 R 5061 CDS An07g04380 84591369 join(927002..927072,927163..927222,927317..927506,927622..927672,927774..927791) IV 1 NT_166523.1 hypothetical protein 927791 84591369 An07g04380 Aspergillus niger hypothetical protein XP_059605387.1 927002 D 5061 CDS An07g04390 4981705 join(928727..929834,929869..930482) IV 1 NT_166523.1 Catalytic activity: oxidizes 6-hydroxy-D-nicotine to 6-hydroxy-N-methylmyosmine.; Complex: FAD is noncovalently bound to A. oxidans 6-HDNO.; Function: A. oxidans 6-HDNO is involved in nicotine-acetyl-CoA catabolism.; Title: similarity to 6-Hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 3622516; uncharacterized protein 930482 4981705 An07g04390 Aspergillus niger uncharacterized protein XP_059605388.1 928727 D 5061 CDS An07g04400 84591370 931535..931783 IV 1 NT_166523.1 Function: the C. reinhardtii class V protein is postulated to be a component of the zygote cell wall.; Title: strong similarity to class V zygote-specific protein - Chlamydomonas reinhardtii; See PMID 1552907; uncharacterized protein 931783 84591370 An07g04400 Aspergillus niger uncharacterized protein XP_059605389.1 931535 D 5061 CDS An07g04410 84591371 932537..933505 IV 1 NT_166523.1 Title: similarity to hypothetical protein encoded by An16g01460 - Aspergillus niger; uncharacterized protein 933505 84591371 An07g04410 Aspergillus niger uncharacterized protein XP_059605390.1 932537 D 5061 CDS An07g04420 4981708 complement(join(933667..933909,933981..935482,935579..935703,935756..935792,935848..935962,936041..936427,936486..936638,936706..936847,936900..936943,937005..937053,937109..937341)) IV 1 NT_166523.1 Catalytic activity: beta-galactosidases hydrolyse terminal, non-reducing beta-D-galactose residues in beta-D-galactosides.; Function: A. niger lacA is involved in carbohydrate utilisation.; Induction: high expression of A. niger lacA was detected on arabinose, xylose, xylan, and pectin.; Title: strong similarity to secreted beta-galactosidase lacA - Aspergillus niger; extracellular/secretion proteins; See PMID 10347026; See PMID 1368193; uncharacterized protein 937341 4981708 An07g04420 Aspergillus niger uncharacterized protein XP_059605391.1 933667 R 5061 CDS An07g04430 4981709 complement(join(938608..938881,938941..940200,940238..940287)) IV 1 NT_166523.1 Function: S. pombe Ght2 shows substrate specificity for D-glucose.; Function: expression of the S. pombe Ght1, Ght2,Ght5, and Ght6 genes in the S. cerevisiae mutant RE700A functionally complement its D-glucose uptake-deficient phenotype.; Similarity: S. pombe Ght2 belongs to the sugar porter subfamily within the major facilitator superfamily.; Similarity: the C-terminal region of the predicted A. niger ORF is identical to EST an_0692 Aspergillus niger,EMBLEST:BE760803.; Title: strong similarity to hexose transporter ght2p - Schizosaccharomyces pombe; plasma membrane; See PMID 10735857; uncharacterized protein 940287 4981709 An07g04430 Aspergillus niger uncharacterized protein XP_059605392.1 938608 R 5061 CDS An07g04440 84591372 join(940405..940528,940668..940823,940874..941042,941204..941332,941423..941528,941655..941987) IV 1 NT_166523.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 941987 84591372 An07g04440 Aspergillus niger uncharacterized protein XP_059605393.1 940405 D 5061 CDS An07g04450 84591373 join(942596..942838,942930..943031,943114..943234,943390..943481) IV 1 NT_166523.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 943481 84591373 An07g04450 Aspergillus niger uncharacterized protein XP_059605394.1 942596 D 5061 CDS An07g04460 84591374 complement(join(943541..943842,943933..944062,944124..944201)) IV 1 NT_166523.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 944201 84591374 An07g04460 Aspergillus niger uncharacterized protein XP_059605395.1 943541 R 5061 CDS An07g04470 4981713 join(944420..944955,945010..945090,945149..945554,945610..946125) IV 1 NT_166523.1 Catalytic activity: cholinesterases convert an acylcholine + H(2)O to choline + a carboxylic acid anion.; Title: strong similarity to butyrylcholinesterase BChE - Oryctolagus cuniculus; See PMID 7925428; uncharacterized protein 946125 4981713 An07g04470 Aspergillus niger uncharacterized protein XP_001391529.1 944420 D 5061 CDS An07g04480 4981714 complement(join(946297..947369,947418..949590)) IV 1 NT_166523.1 Similarity: the C-terminal region of the predicted A. niger protein shows similarity to the C-terminal domain of S. coelicolor SCD8A. 32c.; Similarity: the N-terminus of the predicted A. niger protein shows similarity to the acidic C-terminal domain of two mRNA interacting proteins from S. cerevisiae, NMD2 and IFS1.; Title: strong similarity to hypothetical protein EAA64298.1 - Aspergillus nidulans; uncharacterized protein 949590 4981714 An07g04480 Aspergillus niger uncharacterized protein XP_001391530.3 946297 R 5061 CDS An07g04490 4981715 join(950172..950353,950422..950656,950729..950927,950985..951407,951462..952342) IV 1 NT_166523.1 Similarity: similarity is from the central region of the predicted A. niger protein to the central region of human trans-Golgi 230p, which is 1700 aa longer.; Title: weak similarity to trans-Golgi p230 - Homo sapiens; See PMID 8626529; uncharacterized protein 952342 4981715 An07g04490 Aspergillus niger uncharacterized protein XP_001391531.1 950172 D 5061 CDS An07g04500 4981716 join(954451..954556,954614..954789,954860..956143) IV 1 NT_166523.1 Remark: blastp with the predicted A. niger protein only retrieves random hits to serine and proline rich proteins.; hypothetical protein 956143 4981716 An07g04500 Aspergillus niger hypothetical protein XP_001391532.1 954451 D 5061 CDS An07g04510 4981717 complement(join(956447..956557,956656..957039)) IV 1 NT_166523.1 hypothetical protein 957039 4981717 An07g04510 Aspergillus niger hypothetical protein XP_059605396.1 956447 R 5061 CDS An07g04520 4981718 complement(join(958331..959268,959325..>959973)) IV 1 NT_166523.1 Remark: ORF 5'truncated due to end of contig.; Title: weak similarity to hypothetical protein K06A9.1a - Caenorhabditis elegans [truncated ORF]; uncharacterized protein 959973 4981718 An07g04520 Aspergillus niger uncharacterized protein XP_001391534.3 958331 R 5061 CDS An07g04530 84591375 join(<960159..960374,960503..960681,960770..960901,961091..961195,961361..961541,961814..961929,962045..962285,962360..962368) IV 1 NT_166523.1 Remark: ORF 5'truncated due to end of contig.; Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF [truncated ORF]; uncharacterized protein 962368 84591375 An07g04530 Aspergillus niger uncharacterized protein XP_059603816.1 960159 D 5061 CDS An07g04540 4981720 join(962959..963311,963471..963752,963804..964054,964108..964775) IV 1 NT_166523.1 Title: similarity to hypothetical protein SPBC1685.08 - Schizosaccharomyces pombe; uncharacterized protein 964775 4981720 An07g04540 Aspergillus niger uncharacterized protein XP_001391536.3 962959 D 5061 CDS An07g04550 84591376 join(965637..965918,966004..966222,966283..966957) IV 1 NT_166523.1 Title: strong similarity to hypothetical yellow-related protein - Deinococcus radiodurans; uncharacterized protein 966957 84591376 An07g04550 Aspergillus niger uncharacterized protein XP_059603817.1 965637 D 5061 CDS An07g04560 4981722 join(967317..968043,968123..968559) IV 1 NT_166523.1 Function: A. parasiticus norA has norsolorinic acid reductase (NOR) activity.; Function: A. parasiticus norA is genomically localised within the aflatoxin biosynthetic cluster and has been implicated in aflatoxin biosynthesis.; Induction: A. parasiticus norA mRNA and protein is present only when the fungus is grown in medium conducive to aflatoxin biosynthesis.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Similarity: A. parasiticus norA belongs to the aldo/keto reductase 2 family.; Title: strong similarity to norsolorinic acid reductase norA - Aspergillus parasiticus; See PMID 8593042; uncharacterized protein 968559 4981722 An07g04560 Aspergillus niger uncharacterized protein XP_001391538.1 967317 D 5061 CDS An07g04570 84591377 complement(<970058..970709) IV 1 NT_166523.1 Function: N. crassa Hex1 is required for the assembly of the Woronin body, a new category of peroxisome with a function in the maintenance of cellular integrity.; Function: deletion of HEX1 in N. crassa eliminates Woronin bodies from the cytoplasm and results in hyphae that exhibit a cytoplasmic-bleeding phenotype in response to cell lysis.; Localization: in N. crassa immunoelectron microscopy shows localization of Hex1 to the matrix of the Woronin body.; Remark: a possible sequencing error leads to a frame shift.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to hex1 - Aspergillus nidulans [putative frameshift]; peroxisome; putative frameshift; See PMID 10783241; uncharacterized protein 970709 84591377 An07g04570 Aspergillus niger uncharacterized protein XP_059603818.1 970058 R 5061 CDS An07g04580 4981724 complement(join(972377..972542,972610..972668,972762..973127,973242..973379)) IV 1 NT_166523.1 hypothetical protein 973379 4981724 An07g04580 Aspergillus niger hypothetical protein XP_059603819.1 972377 R 5061 CDS An07g04590 84591378 complement(974395..>977625) IV 1 NT_166523.1 Function: human SRm300, a 300-kDa nuclear matrix antigen, functions in splicing by promoting critical interactions between splicing factors bound to pre-mRNA,including snRNPs and SR family proteins.; Function: specific depletion of human SRm300 does not prevent the splicing of pre-mRNAs.; Remark: ORF 5'truncated due to end of contig.; Title: similarity to splicing coactivator subunit SRm300 - Homo sapiens [truncated ORF]; nucleus; See PMID 10668804; uncharacterized protein 977625 84591378 An07g04590 Aspergillus niger uncharacterized protein XP_059603820.1 974395 R 5061 CDS An07g04600 4981725 complement(join(<977751..978407,978468..978503)) IV 1 NT_166523.1 Remark: ORF 3'truncated due to end of contig.; Remark: blastp with the predicted A. niger protein only retrieves random hits to serine rich proteins.; hypothetical protein [truncated ORF] 978503 4981725 An07g04600 Aspergillus niger hypothetical protein [truncated ORF] XP_001391541.3 977751 R 5061 CDS An07g04610 4981727 979269..980480 IV 1 NT_166523.1 Catalytic activity: epoxide hydrolases convert an epoxide + H(2)O to a glycol.; Function: rat epoxide hydrolase acts on epoxides (alkene oxides, oxiranes) and arene oxides, degrading potential toxic epoxides and determining steady state levels of physiological mediators.; Localization: rat epoxide hydrolase has been localised to the microsomal fraction.; Title: similarity to epoxide hydrolase - Rattus norvegicus; See PMID 8349641; See PMID 10720753; uncharacterized protein 980480 4981727 An07g04610 Aspergillus niger uncharacterized protein XP_001391543.1 979269 D 5061 CDS An07g04620 4981728 complement(join(980767..980973,981056..981369,981430..981643)) IV 1 NT_166523.1 Similarity: the predicted A. niger ORF is identical to two sets of A. niger ESTs, an_2385 and an_3026 aligning for the first 390 bp, while an_3615, an_2148 and an_1658 align from bp 400 on.; Title: strong similarity to hypothetical protein EAA60744.1 - Aspergillus nidulans; uncharacterized protein 981643 4981728 An07g04620 Aspergillus niger uncharacterized protein XP_001391544.1 980767 R 5061 CDS An07g04630 84591379 join(981915..982053,982148..982343,982449..982524,982805..982853,982942..983000) IV 1 NT_166523.1 Remark: an error occured concerning the TREMBL accesion no. which should read AF137223 instead of AF137223_1.; Title: weak similarity to mixed lineage leukemia-like protein Mll - Chanos chanos; See PMID 10468597; uncharacterized protein 983000 84591379 An07g04630 Aspergillus niger uncharacterized protein XP_059600903.1 981915 D 5061 CDS An07g04640 4981730 join(984425..984962,985048..985394) IV 1 NT_166523.1 hypothetical protein 985394 4981730 An07g04640 Aspergillus niger hypothetical protein XP_001391546.1 984425 D 5061 CDS An07g04650 4981731 complement(join(985808..985952,986003..987566,987633..987912)) IV 1 NT_166523.1 Catalytic activity: exo-beta-1,3-glucanases successively hydrolyse beta-D-glucose units from the non-reducing ends of 1,3-beta-D-glucans, releasing alpha-glucose.; Function: S. cerevisiae BGL2 shows lectin-like binding to beta-1,3-glucan and chitin and is involved in carbohydrate utilisation.; Similarity: similarity is from the C-terminal region of the predicted A. niger protein to S. cerevisiae BGL2,which is 300 aa shorter.; Title: similarity to glucan 1,3-beta-glucosidase Bgl2 - Saccharomyces cerevisiae; cell wall; See PMID 2509432; uncharacterized protein 987912 4981731 An07g04650 Aspergillus niger uncharacterized protein XP_059600904.1 985808 R 5061 CDS An07g04660 4981732 complement(join(989702..990441,990800..991861,991962..992214,993245..993319)) IV 1 NT_166523.1 Title: similarity to hypothetical protein CAD25113.1 - Encephalitozoon cuniculi; See PMID 2690004; uncharacterized protein 993319 4981732 An07g04660 Aspergillus niger uncharacterized protein XP_003188709.2 989702 R 5061 CDS An07g04670 84591380 join(993674..993802,993906..993923) IV 1 NT_166523.1 Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 993923 84591380 An07g04670 Aspergillus niger uncharacterized protein XP_059600905.1 993674 D 5061 CDS An07g04680 84591381 join(995524..995680,995771..995922) IV 1 NT_166523.1 Remark: blastp shows significant similarity (57% positives) between the predicted A. niger protein and P. falciparum PFC0920w but due to shortness of both peptides the calculated probability is low (p=1,5).; Title: similarity to hypothetical histone H2A variant PFC0920w - Plasmodium falciparum; uncharacterized protein 995922 84591381 An07g04680 Aspergillus niger uncharacterized protein XP_059600906.1 995524 D 5061 CDS An07g04690 84591382 complement(join(1003333..1003529,1003702..1003801,1003856..1003930,1004165..1004352,1004455..1004542,1004660..1004698,1004741..1004755)) IV 1 NT_166523.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1004755 84591382 An07g04690 Aspergillus niger uncharacterized protein XP_059600907.1 1003333 R 5061 CDS An07g04695 84591383 join(1005344..1005398,1005507..1005529) IV 1 NT_166523.1 hypothetical protein 1005529 84591383 An07g04695 Aspergillus niger hypothetical protein XP_059600908.1 1005344 D 5061 CDS An07g04700 4981737 complement(join(1006217..1006248,1006372..1006416,1006474..1006784,1006877..1006997,1007256..1007393,1007445..1009257)) IV 1 NT_166523.1 Remark: blastp with the predicted A. niger protein only retrieves random hits to serine and argenine rich proteins.; hypothetical protein 1009257 4981737 An07g04700 Aspergillus niger hypothetical protein XP_059600909.1 1006217 R 5061 CDS An07g04710 84591384 join(1010345..1010458,1010486..1010612,1010705..1010937) IV 1 NT_166523.1 Similarity: similarity is from the predicted A. niger protein to the N-terminal region of human engrailed 1, which is 150 aa longer.; Title: weak similarity to homeotic protein engrailed 1 - Homo sapiens; uncharacterized protein 1010937 84591384 An07g04710 Aspergillus niger uncharacterized protein XP_059600910.1 1010345 D 5061 CDS An07g04720 84591385 complement(join(1011889..1012026,1012228..1012295,1012326..1012407)) IV 1 NT_166523.1 hypothetical protein 1012407 84591385 An07g04720 Aspergillus niger hypothetical protein XP_059600911.1 1011889 R 5061 CDS An07g04730 4981740 complement(join(1013804..1014258,1014487..1014641,1014698..1015187,1015241..1015250,1015284..1015349)) IV 1 NT_166523.1 Remark: also strong similarity to human Gene #6 associated peptide #4 patent WO200107459-A1.; Title: strong similarity to gene #6 associated peptide #4 from patent WO200107459-A1 - Homo sapiens; uncharacterized protein 1015349 4981740 An07g04730 Aspergillus niger uncharacterized protein XP_059600912.1 1013804 R 5061 CDS An07g04740 84591386 complement(join(1015403..1015720,1015888..1016087,1016207..1016278,1016387..1016765,1016859..1017268,1017395..1017513,1017746..1018041)) IV 1 NT_166523.1 Remark: a splice site was detected upstream of the START codon.; hypothetical protein 1018041 84591386 An07g04740 Aspergillus niger hypothetical protein XP_059600913.1 1015403 R 5061 CDS An07g04750 84591387 complement(join(1018849..1018955,1019453..1019732)) IV 1 NT_166523.1 Title: questionable ORF; uncharacterized protein 1019732 84591387 An07g04750 Aspergillus niger uncharacterized protein XP_059600914.1 1018849 R 5061 CDS An07g04760 84591388 complement(join(1020417..1020539,1020695..1020791,1020909..1020933,1021009..1021064,1021140..1021192,1021239..1021327,1021606..1021627)) IV 1 NT_166523.1 Remark: only a glycin rich region is matching to homologe proteins.; hypothetical protein 1021627 84591388 An07g04760 Aspergillus niger hypothetical protein XP_059600915.1 1020417 R 5061 CDS An07g04770 4981744 complement(join(1023945..1024705,1024803..1026686,1026735..1027527)) IV 1 NT_166523.1 Remark: the highly acidic nature of the NF-180 sidearm, makes it unlikely that phosphorylation of sidearm residues regulates interfilament spacing and axon diameter through global electrostatic repulsion of the carboxy-terminus away from the filament backbone.; Title: similarity to neurofilament subunit NF-180 -Petromyzon marinus; See PMID 7770000; uncharacterized protein 1027527 4981744 An07g04770 Aspergillus niger uncharacterized protein XP_059600916.1 1023945 R 5061 CDS An07g04780 4981745 join(1028320..1028775,1028833..1028976,1029040..1029224,1029279..1035270,1035338..1035774,1035855..1035861) IV 1 NT_166523.1 Catalytic activity: ATP + H2O = ADP + orthophosphate.; Remark: overexpression of myo2+ results in the inhibition of cytokinesis; cells become elongated and multinucleate and fail to assemble a functional cytokinetic actin ring and are either aseptate or form aberrant septa.; Remark: these results suggest that a contractile actin-myosin based cytokinetic mechanism appeared early in the evolution of eukaryotic cells and further emphasise the utility of fission yeast as a model organism in which to study the molecular and cellular basis of cytokinesis.; Title: strong similarity to myosin II myo2p -Schizosaccharomyces pombe; See PMID 9415380; uncharacterized protein 1035861 4981745 An07g04780 Aspergillus niger uncharacterized protein XP_001391561.3 1028320 D 5061 CDS An07g04790 4981746 join(1036515..1036517,1036693..1037448) IV 1 NT_166523.1 Remark: Isy1p is part of the splicing machinery,associated with spliceosomes throughout the splicing reactions. At least a portion of the Isy1 protein population is associated with snRNAs; low levels of U5 and U6 snRNAs are coimmunoprecipitated specifically with Isy1p.; Remark: also strong similarity to Human ORFX ORF1702 polypeptide sequence SEQ ID NO:3404 patent WO200058473-A2.; Remark: alternative name is Isy1p.; Title: strong similarity to pre-mRNA splicing factor Utr3 - Saccharomyces cerevisiae; See PMID 10094305; uncharacterized protein 1037448 4981746 An07g04790 Aspergillus niger uncharacterized protein XP_059600917.1 1036515 D 5061 CDS An07g04800 4981747 complement(join(1037719..1038462,1038536..1038802)) IV 1 NT_166523.1 Function: the patent holder claims the GTP-binding protein to be important for treating and/or diagnosing diseases associated with GBAP (guanosine triphosphate-binding associated proteins) expression, such as cancer, diabetes and asthma, but nothing is mentioned about direct involvement in signal transduction.; Remark: strong similarity to human GTP-binding associated protein #8 of patent WO200105970-A2 found in PATENTPROT:AAB68508.; Title: strong similarity to GTP-binding associated protein #8 from patent WO200105970-A2 - Homo sapiens; uncharacterized protein 1038802 4981747 An07g04800 Aspergillus niger uncharacterized protein XP_001391563.1 1037719 R 5061 CDS An07g04810 4981748 join(1039477..1039937,1039991..1040084,1040143..1041074,1041131..1041701) IV 1 NT_166523.1 Remark: YNL275w encodes a nonglycosylated anion transport protein, localized to the plasma membrane. The protein did not bind to concanavalin A by lectin blotting or lectin affinity chromatography. The expressed protein bound specifically to a stilbene disulfonate inhibitor resin (SITS-Affi-Gel), and this binding could be competed by certain anions (HCO3-, Cl-, NO3-, and I-) but not by others (SO4(2-) and PO4(3-)).; Title: strong similarity to anion transporter YNL275w - Saccharomyces cerevisiae; See PMID 11401825; uncharacterized protein 1041701 4981748 An07g04810 Aspergillus niger uncharacterized protein XP_001391564.1 1039477 D 5061 CDS An07g04820 4981749 complement(join(1041966..1044612,1044680..1044738)) IV 1 NT_166523.1 Catalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.; Pathway: inositol phosphate metabolism.; Remark: mammalian Vps34p plays a direct role in targeting lysosomal enzyme precursors to the endocytic pathway in an analogous fashion to its role in the fusion of early endocytic vesicles with endosomes.; Similarity: belongs to the class III phosphoinositide 3-kinases.; Title: strong similarity to phosphatidylinositol 3-kinase vps34 - Rattus norvegicus; See PMID 11171063; uncharacterized protein 1044738 4981749 An07g04820 Aspergillus niger uncharacterized protein XP_001391565.1 1041966 R 5061 CDS An07g04830 4981750 join(1045247..1045553,1045610..1046455,1046514..1046695) IV 1 NT_166523.1 Title: similarity to hypothetical protein BAA90881.1 - Homo sapiens; uncharacterized protein 1046695 4981750 An07g04830 Aspergillus niger uncharacterized protein XP_001391566.1 1045247 D 5061 CDS An07g04840 4981751 join(1047425..1047557,1047680..1048368) IV 1 NT_166523.1 Title: weak similarity to protein fragment SEQ ID NO:33868 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 1048368 4981751 An07g04840 Aspergillus niger uncharacterized protein XP_001391567.1 1047425 D 5061 CDS An07g04850 4981752 complement(1048838..1049878) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein AAM96660.1 - Sphingobium chlorophenolicum; uncharacterized protein 1049878 4981752 An07g04850 Aspergillus niger uncharacterized protein XP_001391568.1 1048838 R 5061 CDS An07g04860 4981753 join(1052554..1052582,1052638..1052875,1052977..1053134,1053373..1054031,1054084..1054222,1054273..1054546) IV 1 NT_166523.1 Function: in pancreatic beta-cells, the high Km glucose transporter GLUT2 catalyzes the first step in glucose-induced insulin secretion by glucose uptake.; Induction: the expression of GLUT2 is regulated by glucose at the transcriptional level.; Title: similarity to hepatic glucose transport protein GLUT2 - Mus musculus; plasma membrane; See PMID 7929431; See PMID 1765007; uncharacterized protein 1054546 4981753 An07g04860 Aspergillus niger uncharacterized protein XP_059600918.1 1052554 D 5061 CDS An07g04870 84591389 complement(join(1055048..1055836,1055890..1056426,1056475..1056691,1056757..1057055)) IV 1 NT_166523.1 Function: RAD53 controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints.; Function: RAD53 phosphorylates proteins on serine,threonine, and tyrosine.; Localization: RAD53 was localized to the nucleus by immunofluorescence.; Phenotype: RAD53 is essential for viability.; Title: similarity to protein kinase Rad53 -Saccharomyces cerevisiae; nucleus; See PMID 1899289; See PMID 8355715; uncharacterized protein 1057055 84591389 An07g04870 Aspergillus niger uncharacterized protein XP_059600919.1 1055048 R 5061 CDS An07g04880 4981755 join(1057443..1057498,1057550..1059062,1059257..1059304,1059362..1059400) IV 1 NT_166523.1 Title: weak similarity to translation initiation factor eIF-2 alpha chain kinase HCR - Rattus norvegicus; uncharacterized protein 1059400 4981755 An07g04880 Aspergillus niger uncharacterized protein XP_001391571.1 1057443 D 5061 CDS An07g04890 84591390 complement(join(1059592..1059690,1059735..1059816,1060019..1060038)) IV 1 NT_166523.1 hypothetical protein 1060038 84591390 An07g04890 Aspergillus niger hypothetical protein XP_059600920.1 1059592 R 5061 CDS An07g04900 4981757 join(1062103..1062165,1062242..1062398,1062464..1062651,1062708..1062757,1062815..1062851) IV 1 NT_166523.1 Remark: The EST sequence is from Aspergillus niger but deviates in several positions from the sequence of the genomic DNA.; Title: strong similarity to EST an_2589 -Aspergillus niger; uncharacterized protein 1062851 4981757 An07g04900 Aspergillus niger uncharacterized protein XP_001391573.1 1062103 D 5061 CDS An07g04910 4981758 complement(join(1062916..1063125,1063260..1063264,1063440..1063514,1063623..1064449,1064628..1065165,1065226..1065313)) IV 1 NT_166523.1 Title: weak similarity to protein SEQ ID NO:7732 from patent WO200253728-A2 - Candida albicans; uncharacterized protein 1065313 4981758 An07g04910 Aspergillus niger uncharacterized protein XP_059600921.1 1062916 R 5061 CDS An07g04920 4981759 join(1065618..1065819,1065893..1065912,1066039..1066188,1066307..1066398,1066624..1067112,1067171..1068623) IV 1 NT_166523.1 Title: similarity to hypothetical protein CAD37023.1 - Neurospora crassa; uncharacterized protein 1068623 4981759 An07g04920 Aspergillus niger uncharacterized protein XP_001391575.3 1065618 D 5061 CDS An07g04930 4981760 complement(join(1070212..1070246,1070420..1071035,1071090..1071900,1072067..1072089)) IV 1 NT_166523.1 Title: weak similarity to secreted polypeptide SEQ ID NR:98 from patent WO2003093453-A2 - Bacillus licheniformis; uncharacterized protein 1072089 4981760 An07g04930 Aspergillus niger uncharacterized protein XP_001391576.3 1070212 R 5061 CDS An07g04940 4981761 join(1074321..1075380,1075435..1075463) IV 1 NT_166523.1 Complex: HOC1 is a subunit of the ANP1-HOC1-MNN11-MNN9 mannosyltransferase complex of the Golgi involved in cell wall integrity.; Golgi; Localization: Immunofluorescence studies localized HOC1 to the Golgi apparatus.; Remark: In S. cerevisiae many of the N-linked glycans on cell wall and periplasmic proteins are modified by the addition of mannan, a large mannose-containing polysaccharide.; Similarity: HOC1 strongly resembles OCH1, a yeast alpha-1,6-mannosyltransferase.; Title: strong similarity to alpha-1,6-mannosyltransferase Hoc1 - Saccharomyces cerevisiae; See PMID 9055074; See PMID 11095735; uncharacterized protein 1075463 4981761 An07g04940 Aspergillus niger uncharacterized protein XP_001391577.1 1074321 D 5061 CDS An07g04950 4981762 complement(join(1075735..1075915,1076228..1078148,1078217..1078262)) IV 1 NT_166523.1 Title: weak similarity to hypothetical protein KIAA1394 - Homo sapiens; uncharacterized protein 1078262 4981762 An07g04950 Aspergillus niger uncharacterized protein XP_001391578.3 1075735 R 5061 CDS An07g04960 4981763 complement(join(1079092..1082170,1082225..1082797,1082857..1083241,1083297..1083413,1083471..1083684,1083749..1083786,1083847..1084294)) IV 1 NT_166523.1 Title: similarity to hypothetical beta transducin-like protein het-e1 - Podospora anserina; uncharacterized protein 1084294 4981763 An07g04960 Aspergillus niger uncharacterized protein XP_059600922.1 1079092 R 5061 CDS An07g04970 84591391 join(1084686..1085201,1085253..1085576) IV 1 NT_166523.1 Title: similarity to hypothetical protein encoded by An15g02610 - Aspergillus niger; uncharacterized protein 1085576 84591391 An07g04970 Aspergillus niger uncharacterized protein XP_059600923.1 1084686 D 5061 CDS An07g04980 4981765 complement(join(1086211..1086297,1086348..1086463,1086519..1086546,1086598..1086795,1086854..1087068,1087127..1087270,1087346..1087677,1087725..1087797,1087863..1087876,1087949..1088121)) IV 1 NT_166523.1 Function: translocation of neutral aliphatic and aromatic amino acids across the plasma membrane of the ascomycete Neurospora crassa requires a functional gene product of the mtr locus.; Title: similarity to N amino acid transport system protein mtr - Neurospora crassa; plasma membrane; See PMID 1838345; See PMID 2843424; uncharacterized protein 1088121 4981765 An07g04980 Aspergillus niger uncharacterized protein XP_001391581.1 1086211 R 5061 CDS An07g04990 4981766 complement(join(1089169..1089585,1089625..1089850,1089936..1090075)) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein SPBC365.16 - Schizosaccharomyces pombe; uncharacterized protein 1090075 4981766 An07g04990 Aspergillus niger uncharacterized protein XP_059600924.1 1089169 R 5061 CDS An07g05000 4981767 join(1090850..1090990,1091054..1091526,1091579..1092525,1092581..1092753) IV 1 NT_166523.1 Catalytic activity: 1-pyrroline-5-carboxylate + NAD(+) + H(2)O = L-glutamate + NADH.; Induction: PUT2 expression is induced by proline.; Pathway: PUT2 catalyzes the second step in the conversion from proline to glutamate.; Remark: proline is converted to glutamate in the yeast S. cerevisiae by the sequential action of two enzymes, proline oxidase and delta 1-pyrroline-5-carboxylate dehydrogenase.; Title: strong similarity to 1-pyrroline-5-carboxylate dehydrogenase precursor Put2 -Saccharomyces cerevisiae; See PMID 3062363; See PMID 6358862; uncharacterized protein 1092753 4981767 An07g05000 Aspergillus niger uncharacterized protein XP_001391583.1 1090850 D 5061 CDS An07g05010 4981768 join(1093774..1093986,1094024..1095145) IV 1 NT_166523.1 Remark: faoP has a covalently bound flavin adenine dinucleotide as a prosthetic group.; Remark: faoP is a fructosyl valine-specific enzyme.; Remark: faoP is an enzyme that can be used for the determination of glycated proteins in blood samples from diabetic patients.; Title: strong similarity to fructosyl amino acid oxidase faoP - Penicillium janthinellum; See PMID 8534116; uncharacterized protein 1095145 4981768 An07g05010 Aspergillus niger uncharacterized protein XP_059600925.1 1093774 D 5061 CDS An07g05020 4981769 complement(join(1095254..1096410,1096466..1096705,1096756..1096837,1096939..1097016)) IV 1 NT_166523.1 Title: weak similarity to regulator protein Uga3 -Saccharomyces cerevisiae; uncharacterized protein 1097016 4981769 An07g05020 Aspergillus niger uncharacterized protein XP_059600926.1 1095254 R 5061 CDS An07g05030 4981770 complement(join(1098104..1099312,1099376..1100110)) IV 1 NT_166523.1 Title: weak similarity to arylsulfotransferase astA - Eubacterium rectale; uncharacterized protein 1100110 4981770 An07g05030 Aspergillus niger uncharacterized protein XP_001391586.1 1098104 R 5061 CDS An07g05040 4981771 join(1103491..1104116,1104196..1104997) IV 1 NT_166523.1 Function: PUT1 converts proline to delta-1-pyrroline-5-carboxylate.; Induction: PUT1 expression is induced by proline and oxygen in the cell.; Localization: PUT1 has a characteristic mitochondrial import signal and the enzyme is localized in the mitochondrial matrix.; Pathway: PUT1 catalyzes the first step in the conversion from proline to glutamate.; Title: strong similarity to proline oxidase Put1 -Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 3125423; See PMID 3537723; uncharacterized protein 1104997 4981771 An07g05040 Aspergillus niger uncharacterized protein XP_001391587.1 1103491 D 5061 CDS An07g05050 4981772 1105682..1106596 IV 1 NT_166523.1 Catalytic activity: L-proline + NAD(P)(+) <=> 1-pyrroline-5-carboxylate + NAD(P)H.; Pathway: P5CR catalyzes the final step in proline biosynthesis.; Title: similarity to pyrroline-5-carboxylate reductase P5CR - Neurospora crassa; See PMID 7565596; uncharacterized protein 1106596 4981772 An07g05050 Aspergillus niger uncharacterized protein XP_001391588.3 1105682 D 5061 CDS An07g05060 4981773 complement(join(1107540..1108259,1108364..1108488,1108557..1108625,1108715..1108928)) IV 1 NT_166523.1 Title: strong similarity to protein kinase catalytic chain homolog DC2 - Drosophila sp.; See PMID 3215511; uncharacterized protein 1108928 4981773 An07g05060 Aspergillus niger uncharacterized protein XP_059600927.1 1107540 R 5061 CDS An07g05070 84591392 join(1108966..1109076,1109123..1109344) IV 1 NT_166523.1 hypothetical protein 1109344 84591392 An07g05070 Aspergillus niger hypothetical protein XP_059600928.1 1108966 D 5061 CDS An07g05080 4981775 complement(join(1109655..1109697,1109748..1109833,1109895..1109979,1110044..1110156,1110227..1110309,1110379..1110391,1110451..1110468,1110545..1110592)) IV 1 NT_166523.1 Function: vacuolar ATPase are responible for acidifying a variety of intracellular compartment in eukaryotic cells.; Phenotype: vacuoles in the VMA11-disrupted S. cerevisiae cells were not assembled with either subunit c or subunits a and b of the H(+)-ATPase, resulting in defects of the activity and in vivo vacuolar acidification.; Remark: vma11 of S. cerevisiae is also called TFP3.; Title: strong similarity to vacuolar H(+)-transporting ATPase chain c - Saccharomyces cerevisiae; See PMID 9030535; See PMID 1491234; See PMID 10825180; See PMID 1830311; uncharacterized protein 1110592 4981775 An07g05080 Aspergillus niger uncharacterized protein XP_001391591.1 1109655 R 5061 CDS An07g05090 4981776 join(1111689..1114344,1114404..1114834,1114890..1115321,1115375..1115452) IV 1 NT_166523.1 Function: ROM1 of S. cerevisiae acts as GDP-GTP exchange protein (GEP) for the Rho1p small GTP-binding protein, which is e. g. required for bud formation.; Remark: other names for the ROM1 protein of S. cerevisiae are protein kinase C suppressor SKC1 or YGR070W.; Similarity: the predicted ORF shows strong similarity to several GDP/GTP exchange proteins, the strongest similarity is found to a predicted rho1 protein of S. pombe.; Title: strong similarity to GDP/GTP exchange protein Rom1 - Saccharomyces cerevisiae; See PMID 9759491; uncharacterized protein 1115452 4981776 An07g05090 Aspergillus niger uncharacterized protein XP_001391592.1 1111689 D 5061 CDS An07g05100 4981777 complement(join(1116489..1117351,1117478..1119101,1119163..1119726)) IV 1 NT_166523.1 Function: het-6 of N. crassa is involved in the restriction of heterokaryon formation during asexual growth.; Similarity: het-6(OR) of N. crassa has three regions of amino acid sequence similarity to the predicted product of the het-e vegetative incompatibility gene in P. anserina and to the predicted product of tol, which mediates mating-type vegetative incompatibility in N. crassa.; Similarity: the predicted ORF is 336 amino acids longer than het-6 of N. crassa. Remark: in filamentous fungi, vegetative cell fusion between genotypically distinct individuals leads to a cell-death reaction known as vegetative or heterokaryon incompatibility.; Title: strong similarity to heterokaryon incompatibility protein het-6 - Neurospora crassa; See PMID 10880472; See PMID 11035941; See PMID 11092825; uncharacterized protein 1119726 4981777 An07g05100 Aspergillus niger uncharacterized protein XP_059600929.1 1116489 R 5061 CDS An07g05110 4981778 complement(join(1121380..1121620,1121677..1122279,1122338..1122425,1122483..1122599,1122665..1122740,1122921..1122935)) IV 1 NT_166523.1 Function: members of the septin gene family are involved in cytokinesis and the organization of new growthcytokinesis; Title: strong similarity to septin aspA -Aspergillus nidulans; cytoskeleton; See PMID 9126618; See PMID 11238387; uncharacterized protein 1122935 4981778 An07g05110 Aspergillus niger uncharacterized protein XP_059600930.1 1121380 R 5061 CDS An07g05120 84591393 join(1123058..1123090,1123266..1123523,1123922..1124015,1124294..1124378,1124468..1124645) IV 1 NT_166523.1 hypothetical protein 1124645 84591393 An07g05120 Aspergillus niger hypothetical protein XP_059600931.1 1123058 D 5061 CDS An07g05130 4981780 join(1124794..1124862,1124909..1125274,1125339..1125869) IV 1 NT_166523.1 Remark: the ORF contains WD-repeats, which are usually present in the beta-subunit of G-proteins.; Title: strong similarity to hypothetical protein AAF54315.1 - Drosophila melanogaster; uncharacterized protein 1125869 4981780 An07g05130 Aspergillus niger uncharacterized protein XP_059600932.1 1124794 D 5061 CDS An07g05140 4981781 complement(join(1126195..1127008,1127073..1127128)) IV 1 NT_166523.1 Function: U1 snRNP 70K proteins are bound to the stemloop I of the U1 small nuclear RNA contained in the U1 small nuclear ribonucleoprotein complex (U1 snRNP), which is involved in the splicing of pre-mRNA.; Similarity: the ORF show strong similarity to U1 snRNP 70K proteins from different species.; Title: strong similarity to 70K U1 small nuclear ribonucleoprotein - Drosophila melanogaster; nucleus; See PMID 10588732; See PMID 1692955; uncharacterized protein 1127128 4981781 An07g05140 Aspergillus niger uncharacterized protein XP_059600933.1 1126195 R 5061 CDS An07g05150 4981782 join(1127674..1127830,1127919..1128080,1128167..1128549,1128613..1128706,1128757..1129385,1129453..1129599) IV 1 NT_166523.1 Function: LIC2 of R. norvegicus is a subunit of dynein, the cytoplasmic multi-subunit complex involved in retrograde organelle transport and some aspects of mitosis.; Remark: is also called LC53/55 or DNCLI2.; Title: strong similarity to dynein light intermediate chain 2 LIC-2 - Rattus norvegicus; cytoskeleton; See PMID 10047518; See PMID 10893222; uncharacterized protein 1129599 4981782 An07g05150 Aspergillus niger uncharacterized protein XP_001391598.1 1127674 D 5061 CDS An07g05160 4981783 complement(join(1130303..1130701,1130755..1131049,1131100..1132034)) IV 1 NT_166523.1 Title: similarity to hypothetical protein C01B10.8 -Caenorhabditis elegans; uncharacterized protein 1132034 4981783 An07g05160 Aspergillus niger uncharacterized protein XP_001391599.1 1130303 R 5061 CDS An07g05170 4981784 join(1132465..1132639,1132740..1133177,1133308..1133639) IV 1 NT_166523.1 hypothetical protein 1133639 4981784 An07g05170 Aspergillus niger hypothetical protein XP_059600934.1 1132465 D 5061 CDS An07g05180 4981785 1134572..1135906 IV 1 NT_166523.1 Function: SAT4 of S. cerevisiae is involved in the regulation of cation uptake probably by activating the Trk1-Trk2 potassium transporter, which increase the influx of potassium and decrease indirectly the membrane potential.; Phenotype: SAT4 gene disruption in S. cerevisiae results in greater cation sensitivity, deficient potassium uptake, growth sensitivity to a variety of toxic cations,including lithium, sodium, calcium, tetramethylammonium,hygromycin B, and low pH; and increased uptake of methylammonium, an indicator of membrane potential.; Phenotype: overexpression of SAT4 (and HAL5) increases the tolerance of S. cerevisiae cells to sodium and lithium.; Remark: SAT4 of S. cerevisiae is also called HAL4.; Similarity: the ORF shows similarity to several protein kinases from different species with various cellular function.; Title: strong similarity to serine/threonine-specific protein kinase Hal4 -Saccharomyces cerevisiae; See PMID 10207057; See PMID 1767593; uncharacterized protein 1135906 4981785 An07g05180 Aspergillus niger uncharacterized protein XP_059600935.1 1134572 D 5061 CDS An07g05190 84591394 complement(join(1136493..1136580,1136614..1136651)) IV 1 NT_166523.1 Remark: the ORF is questionable due to its short lenght of only 41 amino acids.; Title: questionable ORF; uncharacterized protein 1136651 84591394 An07g05190 Aspergillus niger uncharacterized protein XP_059600936.1 1136493 R 5061 CDS An07g05200 84591395 complement(join(1137534..1137641,1137739..1137900,1137996..1138016)) IV 1 NT_166523.1 hypothetical protein 1138016 84591395 An07g05200 Aspergillus niger hypothetical protein XP_059600937.1 1137534 R 5061 CDS An07g05210 4981788 complement(join(1138470..1138597,1138658..1138937,1138994..1140040,1140090..1140206,1140243..1140311)) IV 1 NT_166523.1 Function: acyl-CoA synthetases form carbon-oxygen bonds between carbon and sulfur residues.; Similarity: the ORF shows similarity to fatty acid acyl-CoA synthetases from several bacteria, which probably differ in their substrate specifity (e. g. long chain,medium chain fatty acids).; Title: strong similarity to long-chain-fatty-acid acyl-CoA ligase fenL - Bacillus subtilis; See PMID 9387222; See PMID 10438779; uncharacterized protein 1140311 4981788 An07g05210 Aspergillus niger uncharacterized protein XP_059600938.1 1138470 R 5061 CDS An07g05220 84591396 complement(join(1140357..1140445,1140529..1140634,1140789..1140881,1140951..1141020,1141340..1141389)) IV 1 NT_166523.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght of only 135 amino acids.; Title: questionable ORF; uncharacterized protein 1141389 84591396 An07g05220 Aspergillus niger uncharacterized protein XP_059600939.1 1140357 R 5061 CDS An07g05230 4981790 complement(1141724..1142161) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein mlr4389 - Mesorhizobium loti; uncharacterized protein 1142161 4981790 An07g05230 Aspergillus niger uncharacterized protein XP_001391606.1 1141724 R 5061 CDS An07g05240 4981791 complement(join(1142427..1144863,1144998..1145026)) IV 1 NT_166523.1 Similarity: the ORF shows also unspecific similarity to some glutamic acid-rich proteins.; Title: weak similarity to breast and ovarian cancer associated antigen protein sequence SEQ ID NO:674 from patent WO200055173-A1 - Homo sapiens; uncharacterized protein 1145026 4981791 An07g05240 Aspergillus niger uncharacterized protein XP_059600940.1 1142427 R 5061 CDS An07g05250 84591397 complement(join(1145939..1146030,1146107..1146378,1146460..1146488,1146529..1146543)) IV 1 NT_166523.1 hypothetical protein 1146543 84591397 An07g05250 Aspergillus niger hypothetical protein XP_059600941.1 1145939 R 5061 CDS An07g05260 4981793 join(1146596..1147435,1147489..1148607) IV 1 NT_166523.1 hypothetical protein 1148607 4981793 An07g05260 Aspergillus niger hypothetical protein XP_059600942.1 1146596 D 5061 CDS An07g05270 84591398 complement(join(1148873..1148995,1149061..1149096)) IV 1 NT_166523.1 Remark: the ORF is questionable due to its short lenght of only 52 amino acids.; Title: questionable ORF; uncharacterized protein 1149096 84591398 An07g05270 Aspergillus niger uncharacterized protein XP_059600943.1 1148873 R 5061 CDS An07g05280 4981795 join(1149108..1149209,1149267..1149485,1149583..1149825,1149904..1150284) IV 1 NT_166523.1 Function: pmus1 is an phosphomutase homolog required in addition to the MAL4 gene for constitutive maltase synthesis and utilization in cytoplasmic petite cells.; Phenotype: a high copy number of pmu1 in S. cerevisiae suppresses the temperature sensitivity of the tps2 (trehalose-6-phosphate phosphatase) negative mutant by reducing the levels of trehalose-6-phosphate.; Title: strong similarity to phosphomutase homolog Pmu1 - Saccharomyces cerevisiae; See PMID 7050624; See PMID 8913738; uncharacterized protein 1150284 4981795 An07g05280 Aspergillus niger uncharacterized protein XP_001391611.3 1149108 D 5061 CDS An07g05290 4981796 complement(join(1150586..1151619,1151695..1151743)) IV 1 NT_166523.1 Remark: SPCC1739. 02c of S. pombe is only once reported to be the putative mitochondrial protein L22 (http://www. sanger. ac. uk/cgi-bin/yeastpub/GN_KW_search. p), but also the ORF shows weak similarity to ribosomal protein L22 of T. maritima.; Title: similarity to hypothetical mitochondrial ribosomal protein - Schizosaccharomyces pombe; mitochondrial 54S ribosomal protein uL22m 1151743 4981796 An07g05290 Aspergillus niger mitochondrial 54S ribosomal protein uL22m XP_059600944.1 1150586 R 5061 CDS An07g05310 84591399 complement(1153381..1153905) IV 1 NT_166523.1 hypothetical protein 1153905 84591399 An07g05310 Aspergillus niger hypothetical protein XP_059600945.1 1153381 R 5061 CDS An07g05340 84591400 complement(join(1155287..1155403,1155453..1155532,1155611..1155714,1156059..1156174)) IV 1 NT_166523.1 hypothetical protein 1156174 84591400 An07g05340 Aspergillus niger hypothetical protein XP_059600946.1 1155287 R 5061 CDS An07g05350 4981802 join(1156971..1159031,1159086..1159313,1159368..1159724,1159774..1160526) IV 1 NT_166523.1 Function: Prp24 of S. cerevisiae participates in both the formation and disassembly of the U4/U6 hybrid during splicing.; Remark: Prp24 of S. cerevisiae is also called YMR268C or YM815.; Remark: the homologues U6 snRNP protein in S. pombe is more similar to the ORF than the S. cerevisiae protein (especially with the lenght of 1014 amino acids).; Similarity: the similarity of the ORF to U6 snRNP protein PRP24 of S. cerevisiae is restricted to its C-terminal part, starting with amino acid 657 of the ORF.; Title: strong similarity to U6 snRNP splicing factor Prp24 - Saccharomyces cerevisiae; nucleus; uncharacterized protein 1160526 4981802 An07g05350 Aspergillus niger uncharacterized protein XP_001391615.3 1156971 D 5061 CDS An07g05360 84591401 complement(join(1161046..1161292,1161673..1161802,1161889..1162041,1162098..1162188,1162293..1162361)) IV 1 NT_166523.1 hypothetical protein 1162361 84591401 An07g05360 Aspergillus niger hypothetical protein XP_059600947.1 1161046 R 5061 CDS An07g05370 4981804 join(1163780..1164436,1164482..1164718) IV 1 NT_166523.1 Remark: the correct name for the hypothetical protein Y105C5B. g of C. elegans is probably Y105C5B. 9.; Title: strong similarity to hypothetical protein Y105C5B.9 - Caenorhabditis elegans; uncharacterized protein 1164718 4981804 An07g05370 Aspergillus niger uncharacterized protein XP_059600948.1 1163780 D 5061 CDS An07g05380 4981805 complement(1164860..1166485) IV 1 NT_166523.1 Function: WD-repeats are usually present in the beta-subunit (beta-transducin) of G proteins, which mediate signal transduction.; Function: the het-e-1 gene of the fungus P. anserina is responsible for vegetative incompatibility through specific interactions with different alleles of the unlinked gene, het-c.; Similarity: the similarity of the ORF to het-e-1 of P. anserina is restricte dto a region containing a repeated Trp-Asp motif (also called WD repeat).; Title: strong similarity to beta transducin-like protein het-e1 - Podospora anserina; See PMID 7557402; See PMID 9435787; See PMID 10322433; uncharacterized protein 1166485 4981805 An07g05380 Aspergillus niger uncharacterized protein XP_001391618.1 1164860 R 5061 CDS An07g05390 84591402 complement(join(1166539..1166759,1167179..1167253,1167344..1167400,1167525..1167654)) IV 1 NT_166523.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF; uncharacterized protein 1167654 84591402 An07g05390 Aspergillus niger uncharacterized protein XP_059600949.1 1166539 R 5061 CDS An07g05400 84591403 join(1167891..1168036,1168128..1168258,1168416..1168546,1168650..1168871,1168942..1169127) IV 1 NT_166523.1 hypothetical protein 1169127 84591403 An07g05400 Aspergillus niger hypothetical protein XP_059600950.1 1167891 D 5061 CDS An07g05410 4981808 join(1169568..1169815,1169875..1171999) IV 1 NT_166523.1 Similarity: the similarity of the ORF to SPBC83. 18c of S. pombe is restricted to the N-terminal part of the ORF (ending around amino acid 220), which shows homology to a C2 domain, that is often but not always involved in calcium-dependent phospholipid binding.; Title: similarity to hypothetical protein SPBC83.18c - Schizosaccharomyces pombe; uncharacterized protein 1171999 4981808 An07g05410 Aspergillus niger uncharacterized protein XP_001391621.1 1169568 D 5061 CDS An07g05420 4981809 1172930..1173265 IV 1 NT_166523.1 Remark: the ORF is questionable due to the presence of only one single exon and its short lenght of only 111 amino acids.; Title: questionable ORF; uncharacterized protein 1173265 4981809 An07g05420 Aspergillus niger uncharacterized protein XP_001391622.1 1172930 D 5061 CDS An07g05430 4981810 complement(join(1174150..1174986,1175046..1175210)) IV 1 NT_166523.1 Similarity: the ORF shows similarity to several lipases (EC 3. 1. 1) from different species.; Similarity: the similarity of the ORF to hsl of H. sapiens is restricted to the inner part of both molecules.; Title: similarity to triacylglycerol lipase hsl -Homo sapiens; See PMID 8506334; uncharacterized protein 1175210 4981810 An07g05430 Aspergillus niger uncharacterized protein XP_001391623.1 1174150 R 5061 CDS An07g05440 4981811 1175873..1176649 IV 1 NT_166523.1 Function: maleylacetate reductases contribute to the bacterial catabolism of some usual aromatic compounds like quinol or resorcinol and also to the degradation of aromatic compounds carrying unusual substituents, such as halogen atoms or nitro groups.; Similarity: the ORF shows similarity to several short-chain dehydrogenase/reductase from different species and with various function, most of which are 3-oxoacyl-(acyl carrier protein) reductases, that are involved in fatty acid biosynthesis (EC 1. 1. 1. 100).; Title: strong similarity to maleylacetate reductase macA - Rhodococcus opacus; uncharacterized protein 1176649 4981811 An07g05440 Aspergillus niger uncharacterized protein XP_001391624.1 1175873 D 5061 CDS An07g05450 84591404 join(1177546..1177990,1178074..1178195) IV 1 NT_166523.1 hypothetical protein 1178195 84591404 An07g05450 Aspergillus niger hypothetical protein XP_059600951.1 1177546 D 5061 CDS An07g05460 4981813 1178641..1179633 IV 1 NT_166523.1 Title: strong similarity to hypothetical protein CAE47856.1 - Aspergillus fumigatus; uncharacterized protein 1179633 4981813 An07g05460 Aspergillus niger uncharacterized protein XP_059600952.1 1178641 D 5061 CDS An07g05470 84591405 complement(join(1180228..1180295,1180372..1180435)) IV 1 NT_166523.1 Remark: the predicted ORF is questionable due to its lenght of only 43 amino acids.; Title: questionable ORF; uncharacterized protein 1180435 84591405 An07g05470 Aspergillus niger uncharacterized protein XP_059600953.1 1180228 R 5061 CDS An07g05480 84591406 1180974..1182152 IV 1 NT_166523.1 Title: weak similarity to polypeptide SEQ ID NO:30390 from patent WO200171042-A2 - Drosophila melanogaster; uncharacterized protein 1182152 84591406 An07g05480 Aspergillus niger uncharacterized protein XP_059600954.1 1180974 D 5061 CDS An07g05490 84591407 1182353..1184518 IV 1 NT_166523.1 Function: the expression of spoVK in mother cells from B. subtilis is necessary for the completion of spore development.; Phenotype: mutations in spoVK of B. subtilis block the sporulation at a late stage.; Remark: spoVK of B. subtilis is also called spoVJ and belongs to the cbxx/cfxq superfamily, which members habour conserved sequence motifs.; Similarity: the predicted ORF shows similarity to sporulation specific proteins of different bacteria.; Title: strong similarity to stage V sporulation protein spoVK - Bacillus subtilis; See PMID 2514336; See PMID 6405008; See PMID 1732196; See PMID 1787791; uncharacterized protein 1184518 84591407 An07g05490 Aspergillus niger uncharacterized protein XP_059600955.1 1182353 D 5061 CDS An07g05500 4981817 complement(join(1185159..1185661,1185722..>1185752)) IV 1 NT_166523.1 Function: ctr3 of S. cerevisiae is a component of a trimeric high affinity copper permease, which functions in cooper uptake.; Phenotype: the null mutant of ctr3 from S. cerevisiae grows slower than wild-type under conditons of copper limitation on non-fermentable carbon source.; Remark: ctr3 of S. cerevisiae is also called YLR411W.; Remark: the predicted ORF is N-terminally truncated due to contig border.; Repression: ctr3 of S. cerevisiae is repressed by copper and activated by copper starvation.; Title: strong similarity to copper permease component Ctr3 - Saccharomyces cerevisiae [truncated ORF]; plasma membrane; See PMID 8756349; See PMID 9188496; See PMID 10924521; uncharacterized protein 1185752 4981817 An07g05500 Aspergillus niger uncharacterized protein XP_001391630.1 1185159 R 5061 CDS An07g05510 4981818 1186288..1188138 IV 1 NT_166523.1 Catalytic activity: fre3 of S. cerevisiae catalyses NADH + 2 Fe3(+) = NAD(+) + 2 Fe2(+).; Function: fre3 of S. cerevisiae is a siderophore-iron reductase, which is required for the reduction and uptake of ferrioxamine B-iron and for growth on ferrioxamine B, ferrichrome, triacetylfusarinine C, and rhodotorulic acid in the absence of fre1 and fre2.; Induction: fre3 of S. cerevisiae is metalloregulated by ion and its transcription is controlled through the aft1 transcription factor.; Remark: fre3 of S. cerevisiae is also called O6754 or YOR381w.; Title: strong similarity to ferric reductase Fre2 -Saccharomyces cerevisiae; plasma membrane; See PMID 9726978; See PMID 10341420; See PMID 11120744; uncharacterized protein 1188138 4981818 An07g05510 Aspergillus niger uncharacterized protein XP_001391631.3 1186288 D 5061 CDS An07g05520 4981819 join(1189312..1189452,1189546..1189666,1189720..1189843,1189906..1190345,1190408..1190724) IV 1 NT_166523.1 Catalytic activity: omtB of A. parasiticus converts demethylsterigmatocystin (DMST) to sterigmatocystin (ST) and dihydrodemethylsterigmatocystin (DHDMST) to dihydrosterigmatocystin (DHST).; Function: omtB of A. parasiticus is involved in the biosynthesis of the secondary metabolite and mycotoxin aflatoxin.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Title: strong similarity to O-methyltransferase B omtB - Aspergillus parasiticus; See PMID 10806361; See PMID 9532734; uncharacterized protein 1190724 4981819 An07g05520 Aspergillus niger uncharacterized protein XP_001391632.1 1189312 D 5061 CDS An07g05530 84591408 join(1191527..1191568,1191684..1191800) IV 1 NT_166523.1 Remark: the predicted ORF is short in length, only 52 amino acids, and exhibits suboptimal exon-intron structure.; Title: weak similarity to hypothetical protein encoded by An18g02690 - Aspergillus niger; uncharacterized protein 1191800 84591408 An07g05530 Aspergillus niger uncharacterized protein XP_059600956.1 1191527 D 5061 CDS An07g05540 84591409 complement(join(1192348..1192405,1192530..1192605,1192627..1192660)) IV 1 NT_166523.1 Remark: the predicted ORF is questionable due to its lenght of only 55 amino acids and its suboptimal exon-intron structure.; Title: questionable ORF; uncharacterized protein 1192660 84591409 An07g05540 Aspergillus niger uncharacterized protein XP_059600957.1 1192348 R 5061 CDS An07g05550 4981822 join(1192700..1193189,1193286..1193437) IV 1 NT_166523.1 Remark: the predicted ORF shows also similarities to several different proteins due to the presence of an internal poly-glutamic acid stretch.; Title: weak similarity to signal peptide containing protein HSPP-56 SEQ ID NO:56 from patent WO200000610-A2 -Homo sapiens; uncharacterized protein 1193437 4981822 An07g05550 Aspergillus niger uncharacterized protein XP_001391635.1 1192700 D 5061 CDS An07g05570 4981824 complement(join(1193982..1193996,1194046..1194543,1194591..1194992,1195039..1196676,1196740..1196915,1197185..1197203)) IV 1 NT_166523.1 Catalytic activity: chs1 of A. nidulans catalyzes the alpha-1,4-glycosylation of chitin by UDP-N-acetyl-D-glucosamine producing elongated chitin and UDP.; Function: chs1 of A. nidulans is necessary for the synthesis of the cell wall polysaccharide chitin.; Phenotype: deletion mutants of chs1 from A. nidulans exhibited growth defects on media supplemented with sodium dodecyl sulfate (SDS), high concentration of salts,chitin-binding dyes, or chitin synthase competitive inhibitors, suggesting loss of integrity of the hyphal wall.; Title: strong similarity to chitin synthase chs1 -Aspergillus nidulans; See PMID 10731706; uncharacterized protein 1197203 4981824 An07g05570 Aspergillus niger uncharacterized protein XP_001391636.1 1193982 R 5061 CDS An07g05580 84591410 join(1198047..1198148,1198235..1198351) IV 1 NT_166523.1 Remark: the predicted ORF is questionable due to its lenght of only 72 amino acids.; Title: questionable ORF; uncharacterized protein 1198351 84591410 An07g05580 Aspergillus niger uncharacterized protein XP_059600958.1 1198047 D 5061 CDS An07g05590 84591411 join(1198460..1198474,1198684..1198761) IV 1 NT_166523.1 Remark: the predicted ORF is questionable due to its lenght of only 30 amino acids.; Title: questionable ORF; uncharacterized protein 1198761 84591411 An07g05590 Aspergillus niger uncharacterized protein XP_059600959.1 1198460 D 5061 CDS An07g05600 4981827 join(1199093..1199162,1199221..1199475,1199581..1199786) IV 1 NT_166523.1 Catalytic activity: protein tyrosine phosphatases convert protein tyrosine phosphate + H2O = protein tyrosine + orthophoshate.; Function: stp1 of S. pombe may contribute to the dephosphorylation of tyrosine 15 from Cdc2, thereby activating Cdc2/cyclin B kinase, which then brings about mitosis.; Remark: stp1 of S. pombe is also called SPAC926. 01C or SPAC1071. 12c.; Similarity: the ORF shows similarity to several protein-tyrosine-phosphatases from different species with various cellular function.; Title: strong similarity to small protein-tyrosine-phosphatase stp1p - Schizosaccharomyces pombe; uncharacterized protein 1199786 4981827 An07g05600 Aspergillus niger uncharacterized protein XP_059600960.1 1199093 D 5061 CDS An07g05610 4981828 complement(1200009..1200773) IV 1 NT_166523.1 Function: cat5 of S. cerevisiae is involved in monoxygenase steps in the synthesis of ubiquinone (coenzyme Q) by an unknown mechanism and is a central metabolic regulator required for the derepression of pck1 (phosphoenolpyruvate carboxykinase), and thereby gluconeogenesis.; Phenotype: deletion of cat5 of S. cerevisiae causes a complete loss of glucose derepression affecting gluconeogenic key enzymes.; Remark: cat5 of S. cerevisiae is also called O3284,YOR125c or YOR3284c and belongs to the coq7 protein family.; Title: strong similarity to ubiquinone biosynthesis protein Cat5 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8621692; See PMID 9266513; uncharacterized protein 1200773 4981828 An07g05610 Aspergillus niger uncharacterized protein XP_001391640.1 1200009 R 5061 CDS An07g05620 4981829 join(1201347..1201561,1201653..1202395,1202449..1202588,1202638..1203360) IV 1 NT_166523.1 Function: rtf1 of S. cerevisiae is involved in the control of transcription elongation by regulating the DNA-binding properties of spt15, the TATA box-binding protein, and the relative activities of different TATA elements.; Phenotype: the null mutant of rft1 from S. cerevisiae is viable and can suppress TATA box-binding protein mutants (spt15) in an allele-specific fashion.; Remark: rtf1 of S. cerevisiae is also called YGZ4_YEAST, YGL244W or HRA458.; Title: strong similarity to transcription elongation factor Rtf1 - Saccharomyces cerevisiae; nucleus; See PMID 11014804; See PMID 9234706; uncharacterized protein 1203360 4981829 An07g05620 Aspergillus niger uncharacterized protein XP_001391641.1 1201347 D 5061 CDS An07g05630 4981830 join(1203936..1206703,1206765..1208013) IV 1 NT_166523.1 Similarity: the predicted ORF shows weak similarity to glutamic acid-rich proteins due to its relatively high glutamic acid content.; Title: strong similarity to hypothetical coiled-coil protein - Schizosaccharomyces pombe; uncharacterized protein 1208013 4981830 An07g05630 Aspergillus niger uncharacterized protein XP_001391642.1 1203936 D 5061 CDS An07g05640 4981831 complement(join(1208704..1209280,1209333..1209683,1209737..1210071,1210118..1210501,1210588..1210977)) IV 1 NT_166523.1 Function: nirA of A. nidulans encodes a transcription factor with a GAL4-type zinc finger domain.; Function: nirA of A. nidulans is a pathway-specific regulatory gene of nitrate assimilation.; Phenotype: mutations in nirA of A. nidulans affect the transcription levels of niiA and niaD (a nitrite and a nitrate reductase, respectively).; Remark: an alternate name for nitrate assimilation regulatory protein nirA is transcription factor nirA.; Similarity: the predicted ORF is 200 amino acids shorter at its c-terminal end than nirA of A. nidulans.; Similarity: the predicted ORF overlaps with A. niger EST SEQ ID NO:4207 PATENTDNA:F11684.; Title: strong similarity to nitrate assimilation regulatory protein nirA - Aspergillus nidulans; nucleus; See PMID 347305; See PMID 1538701; See PMID 1990284; uncharacterized protein 1210977 4981831 An07g05640 Aspergillus niger uncharacterized protein XP_059600961.1 1208704 R 5061 CDS An07g05650 4981832 complement(join(1212277..1213364,1213455..1213653)) IV 1 NT_166523.1 Catalytic activity: salicylate hydroxylase of P. putida converts salicylate + NADH + H(+) + O2 = catechol + NAD(+) + H2O + CO2 with FAD as cofactor.; Function: salicylate hydroxylase nahG of P. putida is a FAD-dependent monooxygenase enzyme, which catalyzes the formation of catechol from salicylate, a key intermediate in naphthalene catabolism.; Pathway: nahpthalene catabolism and phenylalanine metabolism.; Similarity: the predicted ORF shows similarities to salicylate hydroxylases of several species.; Title: strong similarity to salicylate hydroxylase nahG - Pseudomonas putida; uncharacterized protein 1213653 4981832 An07g05650 Aspergillus niger uncharacterized protein XP_001391644.1 1212277 R 5061 CDS An07g05660 4981833 complement(join(1214285..1214306,1214450..1216158)) IV 1 NT_166523.1 Function: based on the similarity to fibroin or proteins involved in hyphal formation, it is assummed that the predicted ORF encodes a protein playing a role in filamentous growth of A. niger.; Similarity: due to the presence of glycine/serine/proline-rich repeat stretches in the N-terminal part, the predicted ORF shows similarity to extracellular matrix protein family members or to cell wall-attached proteins which contain similar repeats.; Title: similarity to hypothetical protein EAA64430.1 - Aspergillus nidulans; uncharacterized protein 1216158 4981833 An07g05660 Aspergillus niger uncharacterized protein XP_059605755.1 1214285 R 5061 CDS An07g05670 4981834 complement(1217507..1219123) IV 1 NT_166523.1 Remark: due to the fact that the predicted ORF has no predicted membrane regions, it is assummed that the A. niger protein is in contrast to the homologues S. cerevisiae proteins YOR389w and YPL277c not membrane-associated.; Title: strong similarity to hypothetical membrane protein YOR389w - Saccharomyces cerevisiae; uncharacterized protein 1219123 4981834 An07g05670 Aspergillus niger uncharacterized protein XP_001391646.1 1217507 R 5061 CDS An07g05680 84591412 join(1219500..1219548,1219593..1219676,1220019..1220095) IV 1 NT_166523.1 Remark: the predicted ORF is questionable due to the presence of an unusual intron-exon structure and its lenght of only 69 amino acids.; Title: questionable ORF; uncharacterized protein 1220095 84591412 An07g05680 Aspergillus niger uncharacterized protein XP_059605756.1 1219500 D 5061 CDS An07g05690 10098311 complement(join(1221620..1221702,1221777..1221904,1221962..1222052,1222123..1222271,1222328..1222401,1222457..1222702,1222751..1222882)) IV 1 NT_166523.1 Function: YLL057c of S. cerevisiae is involved in sulfonate catabolism by functioning as an Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, which uses isethionate and taurocholate as best natural substrates.; Induction: the transcription of YLL057c from S. cerevisiae has been shown to increase more than 10-fold under sulphate starvation conditions.; Phenotype: disruption of YLL057c in S. cerevisiae negatively affects the use of isethionate and taurine as sulfur sources.; Remark: YLL057c is also called L0572.; Similarity: the predicted ORF shows similarity to dioxygenases, especially taurine dioxygenases, from several species.; Title: strong similarity to Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase YLL057c -Saccharomyces cerevisiae; See PMID 10482536; See PMID 11223942; uncharacterized protein 1222882 10098311 An07g05690 Aspergillus niger uncharacterized protein XP_003188712.2 1221620 R 5061 CDS An07g05700 84591413 join(1224766..1224851,1225110..1225189,1225294..1225529) IV 1 NT_166523.1 Remark: the predicted ORF is questionable due to the presence of an unusual intron-exon structure.; Title: questionable ORF; uncharacterized protein 1225529 84591413 An07g05700 Aspergillus niger uncharacterized protein XP_059605757.1 1224766 D 5061 CDS An07g05710 4981838 complement(join(1225830..1226564,1226687..1226728)) IV 1 NT_166523.1 hypothetical protein 1226728 4981838 An07g05710 Aspergillus niger hypothetical protein XP_001391650.3 1225830 R 5061 CDS An07g05720 84591414 join(1226834..1226958,1227026..1227112,1227202..1227322,1227385..1227474,1227527..1227586,1227704..1227910,1228027..1228083,1228166..1228228) IV 1 NT_166523.1 hypothetical protein 1228228 84591414 An07g05720 Aspergillus niger hypothetical protein XP_059605758.1 1226834 D 5061 CDS An07g05730 4981840 complement(join(1228445..1228617,1228700..1228865,1228948..1229039,1229089..1229150,1229274..1229627,1229681..1230186)) IV 1 NT_166523.1 Function: srpk2 of M. musculus is involved in the regulation of pre-mRNA splicing by serine/arginine-rich proteins (SR proteins).; Function: srpk2 of M. musculus regulates the disassembly of SR protein-containing nuclear speckles (storage compartments) by phosphorylation and therefore putatively controls the activity of splicing.; Title: strong similarity to SR protein-specific kinase srpk2 - Mus musculus; nucleus; See PMID 9472028; uncharacterized protein 1230186 4981840 An07g05730 Aspergillus niger uncharacterized protein XP_059605759.1 1228445 R 5061 CDS An07g05740 4981841 complement(join(1230621..1230980,1231053..1231248,1231324..1231448,1231517..1231556,1231871..1232001)) IV 1 NT_166523.1 Similarity: the predicted ORF shows similarity to several puatative esterases/lipases from different species.; Title: strong similarity to hypothetical abhydrolase SPAC22H12.03 - Schizosaccharomyces pombe; uncharacterized protein 1232001 4981841 An07g05740 Aspergillus niger uncharacterized protein XP_059605760.1 1230621 R 5061 CDS An07g05750 4981842 join(1232326..1232527,1232620..1233740) IV 1 NT_166523.1 Function: mct1 of C. griseus is a monocarboxylate transporter responsible for the uptake of lactate and pyruvate.; Remark: a Phe to Cys substitution in mct1 of C. griseus converts it to mev, a mevalonate transporter (PIRA44458).; Similarity: the predicted ORF shows strong similarity to several putative monocarboxylate transporters from different species, e. g. YNL125c of S. cerevisiae is a homologue to MCT1 and MCT2.; Title: strong similarity to monocarboxylate transporter 1 mct1 - Cricetulus griseus; plasma membrane; uncharacterized protein 1233740 4981842 An07g05750 Aspergillus niger uncharacterized protein XP_001391654.1 1232326 D 5061 CDS An07g05760 4981843 1234155..1235057 IV 1 NT_166523.1 Title: similarity to hypothetical protein YMR130w -Saccharomyces cerevisiae; uncharacterized protein 1235057 4981843 An07g05760 Aspergillus niger uncharacterized protein XP_001391655.1 1234155 D 5061 CDS An07g05770 84591415 complement(1235647..1235952) IV 1 NT_166523.1 Remark: the predicted ORF partially overlaps with EMBLEST:BE759038 from A. niger.; Similarity: additionally, the predicted ORF overlaps with EMBLEST:BE760450, EMBLEST:BE760893 and PATENTDNA:F11689 EST SEQ ID NO:4212 from A. niger.; Title: strong similarity to EST an_3321 -Aspergillus niger; uncharacterized protein 1235952 84591415 An07g05770 Aspergillus niger uncharacterized protein XP_059605761.1 1235647 R 5061 CDS An07g05780 4981845 join(1236522..1236536,1236588..1237928) IV 1 NT_166523.1 hypothetical protein 1237928 4981845 An07g05780 Aspergillus niger hypothetical protein XP_001391657.1 1236522 D 5061 CDS An07g05790 4981846 complement(join(1238119..1239314,1239364..1240789)) IV 1 NT_166523.1 Function: sgd1 of S. cerevisiae is involved osmoregulatory responses resulting in glycerol production (HOG pathway).; Phenotype: an increased dosage of sgd1 in S. cerevisiae partially suppresses the osmosensitivity of mutants that are defective in the HOG mitogen-activated protein kinase pathway by re-establishing transcriptional control of the osmostress-induced expression of the NAD(+)-dependent glycerol 3-phosphate dehydrogenase.; Phenotype: the null mutant of sgd1 from S. cerevisiae is inviable.; Remark: alternate names for sgd1 are L8300. 12 and YLR336c.; Title: strong similarity to osmoregulatory protein Sgd1 - Saccharomyces cerevisiae; nucleus; See PMID 11042259; uncharacterized protein 1240789 4981846 An07g05790 Aspergillus niger uncharacterized protein XP_059605762.1 1238119 R 5061 CDS An07g05800 4981847 join(1241099..1241125,1241186..1241554) IV 1 NT_166523.1 Function: srp14 of C. familiaris is involved in the targeting of secretory proteins to the rough endoplasmic reticulum membrane.; Function: srp14 together with srp9 are necessary for binding to the alu portion of SRP RNA, which together constitute the elongation domain of the six subunits-containing signal recognition particle (SRP).; Similarity: the similarity of the predicted ORF to srp14 of several species is restricted to the C-terminal part of srp14, starting in the region between amino acid 30 to 60.; Title: similarity to signal recognition particle protein srp14 - Canis lupus; See PMID 9233785; uncharacterized protein 1241554 4981847 An07g05800 Aspergillus niger uncharacterized protein XP_001391659.1 1241099 D 5061 CDS An07g05810 4981848 complement(1241998..1243626) IV 1 NT_166523.1 Similarity: the predicted ORF partially overlaps with A. niger EST EMBLEST:BE758923.; Title: similarity to hypothetical protein CAD60772.1 - Podospora anserina; uncharacterized protein 1243626 4981848 An07g05810 Aspergillus niger uncharacterized protein XP_001391660.1 1241998 R 5061 CDS An07g05820 4981849 join(1244213..1244270,1244535..1244641,1244704..1244876,1244924..1245329,1245381..1245737) IV 1 NT_166523.1 Function: usgS of A. nidulans interferes with the transcription of its 3' end gene formidase fmdS, which has a putative homologue on ORF 82ck (see usgS of A. nidulans).; Title: strong similarity to hypothetical transmembrane protein usgS - Aspergillus nidulans; See PMID 11139496; uncharacterized protein 1245737 4981849 An07g05820 Aspergillus niger uncharacterized protein XP_001391661.1 1244213 D 5061 CDS An07g05830 4981850 join(1246242..1246316,1246378..1246396,1246456..1246744,1246828..1247107,1247159..1247737) IV 1 NT_166523.1 Catalytic activity: fmdS of A. nidulans hydrolyses formamide with the production of ammonia.; Catalytic activity: formamide + H2O = formate + NH3.; Function: fmdS of A. nidulans is involved in the utilization of formamide as nitrogen source.; Induction: the 5' upstream gene of fmdS in A. nidulans interferes with fmdS transcription, resulting in a strong dependence on AreA activation for expression.; Induction: the expression of fmdS of A. nidulans is primarily regulated via AreA, a zinc finger transcription factor, which is the major nitrogen regulatory protein in A. nidulans.; Remark: like in A. nidulans, a gene (ORF 84ck) is located directly 5' to this ORF, which putatively encodes a regulatory transmembrane protein.; Remark: the relative position of the fmdS gene to the usgS gene, like in A. nidulans, might be essential for normal regulation of fmdS.; Title: strong similarity to formamidase fmdS -Aspergillus nidulans; See PMID 11139496; uncharacterized protein 1247737 4981850 An07g05830 Aspergillus niger uncharacterized protein XP_001391662.1 1246242 D 5061 CDS An07g05840 4981851 complement(join(1248074..1248322,1248388..1248492,1248544..1249697,1249797..1249860)) IV 1 NT_166523.1 Function: (see ORF 50wg) hol1 of S. cerevisiae is involved in the uptake of several cations and histidinol,the biosynthetic precursor to histidine.; Phenotype: additional hol1 mutations in S. cerevisiae histidine auxotrophs can confer a novel,non-selective cation transport pattern.; Phenotype: the null mutant of hol1 in S. cerevisiae is viable, but unable to take up histidinol or Na+.; Similarity: strong similarity to ORF 50wg, another major facilitator protein.; Title: strong similarity to multidrug resistance protein Hol1 - Saccharomyces cerevisiae; plasma membrane; See PMID 10436161; See PMID 2405251; uncharacterized protein 1249860 4981851 An07g05840 Aspergillus niger uncharacterized protein XP_059605763.1 1248074 R 5061 CDS An07g05850 84591416 join(1249918..1250096,1250204..1250474,1250588..1250674) IV 1 NT_166523.1 Remark: the predicted ORf is questionable due to its unusally long introns.; Title: questionable ORF; uncharacterized protein 1250674 84591416 An07g05850 Aspergillus niger uncharacterized protein XP_059605764.1 1249918 D 5061 CDS An07g05870 84591417 join(1252247..1252682,1252779..1252816) IV 1 NT_166523.1 Remark: the predicted ORF is questionable due to the unusally short second exon.; Title: questionable ORF; uncharacterized protein 1252816 84591417 An07g05870 Aspergillus niger uncharacterized protein XP_059605765.1 1252247 D 5061 CDS An07g05880 4981855 complement(join(1252934..1253173,1253228..1253486,1253538..1254013,1254071..1254160,1254246..1254638,1254694..1254782,1254833..1254890)) IV 1 NT_166523.1 Function: hol1 of S. cerevisiae is involved in the uptake of several cations and histidinol, the biosynthetic precursor to histidine.; Phenotype: additionally, hol1 mutations in S. cerevisiae histidine auxotrophs can confer a novel,non-selective cation transport pattern.; Phenotype: the null mutant of hol1 in S. cerevisiae is viable, but unable to take up histidinol or Na+.; Remark: hol1 is also called YNR055C or N3494 and belongs to the major facilitator family (drug resistance translocase family).; Title: strong similarity to multidrug resistance protein Hol1 - Saccharomyces cerevisiae; plasma membrane; See PMID 10436161; See PMID 2405251; uncharacterized protein 1254890 4981855 An07g05880 Aspergillus niger uncharacterized protein XP_059605766.1 1252934 R 5061 CDS An07g05890 84591418 join(1254961..1255191,1255272..1255383,1255624..1255781) IV 1 NT_166523.1 Remark: the predicted ORF is questionable due to its unusal exon-intron structure and proximity to the adjacent ORFs.; Title: questionable ORF; uncharacterized protein 1255781 84591418 An07g05890 Aspergillus niger uncharacterized protein XP_059605767.1 1254961 D 5061 CDS An07g05900 4981857 join(1255811..1256003,1256059..1257197) IV 1 NT_166523.1 Catalytic activity: fructosyl amino acid oxidases act on the CH-NH group of donors with oxygen as acceptor under formation of hydrogen peroxide and glucosone.; Function: faoA of A. terreus is an FAD-binding oxidoreductase, which deglycates glycated model compounds like N-epsilon-fructosyl N-sigma-Z-lysine and N-fructosyl valine, oxidatively into free fructosamine.; Remark: fructosyl amino acid oxidase is often used as an enzyme for the determination of glycated Amadori products in blood samples from diabetic patients.; Title: strong similarity to fructosyl amino acid oxidase faoA - Aspergillus terreus; See PMID 8534116; See PMID 9139700; uncharacterized protein 1257197 4981857 An07g05900 Aspergillus niger uncharacterized protein XP_001391668.1 1255811 D 5061 CDS An07g05910 84591419 complement(join(1257421..1257726,1257771..1257962)) IV 1 NT_166523.1 hypothetical protein 1257962 84591419 An07g05910 Aspergillus niger hypothetical protein XP_059605768.1 1257421 R 5061 CDS An07g05920 4981859 join(1258666..1258681,1258752..1258819,1258959..1259052,1259173..1260113) IV 1 NT_166523.1 Function: cypD of B. taurus accelerates folding of proteins by acting as a PPIase, which possesses cis-trans isomerase activity on proline imidic peptide bonds in oligopeptides.; Remark: cyclophilins are the intracellular receptors for the immunosuppressive, anti-fungal drug cyclosporin A.; Remark: cypD of B. taurus is also called ppid, cyp40 or erbc.; Remark: the predicted ORF partially overlaps with A. niger EST AN05D12.; Similarity: the predicted ORF shows similarity to proteins from different species, that all belong to the cyclophilin superfamily and show peptidylprolyl isomerase activity (named PPIases or rotamases).; Title: strong similarity to estrogen receptor-binding cyclophilin cypD - Bos primigenius taurus; See PMID 8509368; See PMID 1530635; See PMID 1544925; See PMID 1825312; uncharacterized protein 1260113 4981859 An07g05920 Aspergillus niger uncharacterized protein XP_059605769.1 1258666 D 5061 CDS An07g05930 4981860 complement(join(1260861..1260980,1261063..1261289,1261356..1261398,1261482..1261660,1261721..1261727)) IV 1 NT_166523.1 Function: D-Tyr-tRNA(Tyr)deacylase dtd1 of S. cerevisiae recycles misaminoacylated D-Tyr-tRNAn(Tyr), a process, which inhibits the accumulation of d-aminoacyl-tRNA molecules and is therefore important for cell rescue.; Phenotype: overexpression of the DTD1 gene in S. cerevisiae increased D-Tyr-tRNA(Tyr) deacylase activity.; Phenotype: upon disruption of the dtd1 chromosomal gene in S. cerevisiae, deacylase activity was decreased by more than 90%, and the sensitivity to D-tyrosine of the growth of S. cerevisiae was exacerbated.; Repression: in S. cerevisiae L-tyrosine auxotrophs,DTD1-like genes are systematically absent.; Similarity: the predicted ORF is 41 amino acids longer at the C-terminus than dtd1 of S. cerevisiae.; Title: strong similarity to D-Tyr-tRNA deacylase Dtd1 - Saccharomyces cerevisiae; See PMID 10766779; See PMID 10918062; uncharacterized protein 1261727 4981860 An07g05930 Aspergillus niger uncharacterized protein XP_001391671.1 1260861 R 5061 CDS An07g05940 4981861 join(1262001..1262073,1262372..1262628,1262700..1264246,1264306..1264366) IV 1 NT_166523.1 Function: not3 of H. sapiens is part of the global negative regulator complex of RNA polymerase II transcription, consisting of the four NOT proteins, CCR4 and CALIF.; Title: strong similarity to transcription regulator not3 - Homo sapiens; nucleus; See PMID 10637334; uncharacterized protein 1264366 4981861 An07g05940 Aspergillus niger uncharacterized protein XP_001391672.3 1262001 D 5061 CDS An07g05950 84591420 complement(join(1265684..1266163,1266503..1266832)) IV 1 NT_166523.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF; uncharacterized protein 1266832 84591420 An07g05950 Aspergillus niger uncharacterized protein XP_059605770.1 1265684 R 5061 CDS An07g05960 4981863 join(1267332..1267352,1267466..1268146) IV 1 NT_166523.1 Function: msn2 of S. cerevisiae together with msn4 is facilitating a transcriptional response of the yeast to cellular stress situations, e. g. osmotic shock by inducing subsets of high osmolarity glycerol pathway-dependent genes.; Title: similarity to finger protein Msn2 -Saccharomyces cerevisiae; See PMID 10722658; See PMID 11292860; uncharacterized protein 1268146 4981863 An07g05960 Aspergillus niger uncharacterized protein XP_059605771.1 1267332 D 5061 CDS An07g05970 4981864 join(1268709..1268814,1269169..1269208,1269268..1269341,1269591..1270136,1270240..1270271,1270529..1270553,1270805..1270877,1271162..1271706,1271766..1271873,1271926..1272093,1272146..1272308,1272373..1272397,1272446..1273080,1273133..1273492,1273549..1277650) IV 1 NT_166523.1 Function: ankyrins are involved in cell adhesion and protein targeting by attaching integral membrane proteins to cytoskeletal elements, e. g. by binding to Na/K-ATPase or to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin.; Title: strong similarity to ankyrin Ank2 - Homo sapiens; See PMID 8253844; See PMID 8557748; See PMID 11427698; uncharacterized protein 1277650 4981864 An07g05970 Aspergillus niger uncharacterized protein XP_059605772.1 1268709 D 5061 CDS An07g05980 4981865 join(1278357..1278485,1278542..1278596,1278636..1278735,1278789..1278856,1278914..1279082,1279133..1279193,1279245..1279751,1279808..1280193,1280244..1280455,1280517..1281007) IV 1 NT_166523.1 Function: G22P2 of H. sapiens is a ATP-dependent DNA unwinding enzyme, which (i) unwinds exclusively DNA duplexes, (ii) prefers partially unwound substrates and (iii) proceeds in the 3' to 5' direction on the bound strand.; Remark: is also called lupus Ku autoantigen protein P86 (KU86), KU80, thyroid-lupus autoantigen (TLAA), CTC box binding factor 85 KDa subunit (CTCBF), CTC85, nuclear factor IV or DNA-repair protein XRCC5.; Similarity: G22P2 of H. sapiens was found to be identical to the previously identified Ku autoantigen recognized by the sera of scleroderma and lupus erythematosus patients.; Title: strong similarity to ATP-dependent DNA helicase II 86 KD subunit G22P2 - Homo sapiens; nucleus; See PMID 2760028; uncharacterized protein 1281007 4981865 An07g05980 Aspergillus niger uncharacterized protein XP_059605773.1 1278357 D 5061 CDS An07g05990 4981866 complement(join(1281272..1281323,1281389..1282551,1282733..1282756,1282941..1283919,1284121..1284368)) IV 1 NT_166523.1 Function: target SNAREs (t-SNAREs) are involved in membrane-fusion processes of exo-/endocytosis, where they act as a complex localized on the target membrane.; Phenotype: U. maydis yup1 mutants are temperature-sensitive and show defects in the polar distribution of cell wall components as well as abnormal morphology.; Similarity: the ORF shows some similarity to other syntaxin-like endosomal SNAREs from different species.; Similarity: the similarity of the ORF to tSNARE yup1 of U. maydis is locally high in its C-terminal part,starting with amino acid 429.; Title: similarity to endosomal t-SNARE yup1 -Ustilago maydis; See PMID 10790364; uncharacterized protein 1284368 4981866 An07g05990 Aspergillus niger uncharacterized protein XP_001391677.3 1281272 R 5061 CDS An07g06000 4981867 complement(join(1284942..1285619,1285678..1286679)) IV 1 NT_166523.1 Catalytic activity: aspartate--tRNA ligases (= aspartyl-tRNA synthetases) facilitate the connection of L-aspartate with its respective tRNA bei catalyzing ATP + L-aspartate + tRNA(Asp) <=> AMP + diphosphate + L-aspartyl-tRNA(Asp).; Remark: dps1 of S. cerevisiae is also called APS1,APS, YLL018C OR L1295.; Title: strong similarity to cytosolic aspartate--tRNA ligase Dps1 - Saccharomyces cerevisiae; cytoplasm; See PMID 3513127; See PMID 3902099; See PMID 2021621; See PMID 2047877; uncharacterized protein 1286679 4981867 An07g06000 Aspergillus niger uncharacterized protein XP_001391678.1 1284942 R 5061 CDS An07g06010 4981868 complement(join(1287020..1287788,1287846..1288148,1288208..1288344)) IV 1 NT_166523.1 Similarity: the ORF shows strong similarity to a postulated phosphatidyl synthase of S. pombe.; Title: strong similarity to hypothetical protein YKR070w - Saccharomyces cerevisiae; uncharacterized protein 1288344 4981868 An07g06010 Aspergillus niger uncharacterized protein XP_001391679.1 1287020 R 5061 CDS An07g06020 4981869 join(1288726..1289105,1289193..1289991) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein YDR306c - Saccharomyces cerevisiae; uncharacterized protein 1289991 4981869 An07g06020 Aspergillus niger uncharacterized protein XP_001391680.1 1288726 D 5061 CDS An07g06030 4981870 complement(join(1290775..1291007,1291064..1291879,1291932..1292279,1292335..1293301,1293367..1293677,1293765..1293840)) IV 1 NT_166523.1 Function: the coatomer complex is involved in the targeting of proteins via the Golgi and retrograde Golgi to ER transport.; Function: the gamma-COP subunit of the coatomer is believed to mediate the binding to the cytoplasmic dilysine motifs of membrane proteins.; Title: strong similarity to coatomer gamma subunit 2 copg2 - Homo sapiens; See PMID 10874328; See PMID 10995575; See PMID 11018518; uncharacterized protein 1293840 4981870 An07g06030 Aspergillus niger uncharacterized protein XP_001391681.1 1290775 R 5061 CDS An07g06040 4981871 join(1294418..1294455,1294511..1294693,1294768..1295123,1295177..1295325) IV 1 NT_166523.1 Function: phosducins are known to bind G protein betagamma subunits in vitro, and are postulated to regulate their signaling function in vivo.; Function: plp2 of S. cerevisiae putatively acts as an inhibitor of G-protein GTPase activity, which results in selective regulation of early signaling events following pheromone stimulation and has an essential role in cell growth independent of its regulatory role in cell signaling.; Similarity: the ORF overlaps with A. niger EST an_3248 database entry EMBLEST:BE758982.; Title: strong similarity to phosducin homolog Plp2 -Saccharomyces cerevisiae; See PMID 10371466; See PMID 10749875; uncharacterized protein 1295325 4981871 An07g06040 Aspergillus niger uncharacterized protein XP_001391682.1 1294418 D 5061 CDS An07g06050 4981872 join(1296174..1296305,1296370..1296638,1296705..1297218) IV 1 NT_166523.1 Remark: originally, the name yap3 was used for yeast aspartyl protease 3, which was renamed in yps1.; Remark: yap3 of S. cerevisiae binds most efficiently to TTACTAA, a sequence that differs at position +/-2 from the optimal AP-1 site (TGACTCA).; Similarity: the similarity of the ORF to transcription factors is locally high in the specific DNA-binding region containing a bZIP (basic-leucine zipper) motive, which is encoded by amino acid 126 to 142 of the ORF.; Title: similarity to bZIP transcription factor Yap3 - Saccharomyces cerevisiae; See PMID 9090053; See PMID 9372930; uncharacterized protein 1297218 4981872 An07g06050 Aspergillus niger uncharacterized protein XP_001391683.1 1296174 D 5061 CDS An07g06060 84591421 join(1297783..1297850,1298251..1298335,1298430..1298499,1298742..1298960,1299069..1299153,1299239..1299404) IV 1 NT_166523.1 hypothetical protein 1299404 84591421 An07g06060 Aspergillus niger hypothetical protein XP_059605774.1 1297783 D 5061 CDS An07g06070 84591422 complement(join(1299950..1300024,1300405..1300707,1300849..1300989)) IV 1 NT_166523.1 Remark: the ORF has a suboptimal intron-exon structure and shows only unspecific similarity to lysine-rich proteins.; hypothetical protein 1300989 84591422 An07g06070 Aspergillus niger hypothetical protein XP_059605775.1 1299950 R 5061 CDS An07g06080 4981875 join(1301178..1301189,1301250..1301322,1301387..1302414) IV 1 NT_166523.1 Function: hhp1 of S. pombe is a casein kinase,specific for serine/threonine residues, which is involved in the regulation of DNA repair.; Phenotype: S. pombe strains lacking either or both hhp activities (hhp1 or hhp2) reveal differences in their ability to withstand DNA lesions caused by either methyl methanesulfonate (MMS) or gamma-rays which correlate with their ability to repair DNA strand breaks caused by these agents.; Similarity: the similarity to casein kinases from different species is high in the N-terminal part with protein kinase specific motivs, but lower in the C-terminal region, where glycine/proline rich stretches are present in casein kinases.; Title: strong similarity to casein kinase-1 homolog hhp1p - Schizosaccharomyces pombe; uncharacterized protein 1302414 4981875 An07g06080 Aspergillus niger uncharacterized protein XP_001391686.3 1301178 D 5061 CDS An07g06090 84591423 1303364..1303756 IV 1 NT_166523.1 Similarity: the ORF shows similarity to A. niger ESTs an_3627 database entry EMBLEST:BE759275 and an_2936 entry EMBLEST:BE759984.; Title: strong similarity to EST an_3627 -Aspergillus niger; uncharacterized protein 1303756 84591423 An07g06090 Aspergillus niger uncharacterized protein XP_059605776.1 1303364 D 5061 CDS An07g06100 4981877 complement(join(1304696..1308245,1308318..1308600,1308677..1309076,1309182..1309451)) IV 1 NT_166523.1 Function: tea1 of S. pombe is involved in maintaining cell integrity and directs the growth machinery by acting as an end marker at the microtubulin-associated cell poles.; Repression: tea1 of S. pombe is down-regulated in cells treated with pheromone that grow toward a mating partner and no longer maintain their ends exactly opposed.; Title: strong similarity to cell polarity protein tea1p - Schizosaccharomyces pombe; See PMID 9200612; uncharacterized protein 1309451 4981877 An07g06100 Aspergillus niger uncharacterized protein XP_001391688.1 1304696 R 5061 CDS An07g06110 84591424 complement(join(1310243..1310391,1310480..1310587,1310678..1310739,1310844..1311041,1311267..1311367)) IV 1 NT_166523.1 hypothetical protein 1311367 84591424 An07g06110 Aspergillus niger hypothetical protein XP_059605777.1 1310243 R 5061 CDS An07g06120 84591425 complement(join(1311539..1311595,1311919..1312150,1312200..1312325,1312381..1312497,1312623..1312654)) IV 1 NT_166523.1 hypothetical protein 1312654 84591425 An07g06120 Aspergillus niger hypothetical protein XP_059605778.1 1311539 R 5061 CDS An07g06130 4981880 join(1314067..1314501,1314560..1316615,1316673..1317289,1317365..1317615,1317663..1317996,1318047..1318628) IV 1 NT_166523.1 Remark: the hypothetical protein YHR186c of S. cerevisiae is a putative membrane protein, but for the ORF no membrane region is predicted.; Title: strong similarity to hypothetical guanine nucleotide binding protein - Schizosaccharomyces pombe; uncharacterized protein 1318628 4981880 An07g06130 Aspergillus niger uncharacterized protein XP_059605779.1 1314067 D 5061 CDS An07g06140 4981881 complement(join(1319018..1319050,1319105..1319115,1319346..1319391,1319425..1319515,1319705..1319818,1319902..1320008,1320081..1320476,1320592..1320795,1321205..1321492)) IV 1 NT_166523.1 Title: weak similarity to apoptosis associated protein YDR442W from patent WO200102550-A2 - Saccharomyces cerevisiae; uncharacterized protein 1321492 4981881 An07g06140 Aspergillus niger uncharacterized protein XP_059605780.1 1319018 R 5061 CDS An07g06150 4981882 join(1321927..1322073,1322129..1322492,1322529..1322577,1322612..1322647,1322714..1323472,1323535..1324135,1324213..1324286,1324346..1324444,1324497..1324527) IV 1 NT_166523.1 Catalytic activity: erg7 of S. cerevisiae converts (S)-2,3-epoxysqualene <=> lanosterol.; Function: erg7 of S. cerevisiae catalyzes the cyclization of (S)-2,3-epoxysqualene to lanosterol, the initial precursor of cholesterol, steroid hormones and vitamin D in vertebrates and of ergosterol in fungi (gene ERG7).; Remark: is also called OSC or YHR07.; Title: strong similarity to lanosterol synthase erg7p - Schizosaccharomyces pombe; endoplasmatic reticulum; See PMID 8604986; uncharacterized protein 1324527 4981882 An07g06150 Aspergillus niger uncharacterized protein XP_059605781.1 1321927 D 5061 CDS An07g06160 4981883 complement(1324886..1326031) IV 1 NT_166523.1 hypothetical protein 1326031 4981883 An07g06160 Aspergillus niger hypothetical protein XP_001391694.1 1324886 R 5061 CDS An07g06170 4981884 complement(join(1326566..1327053,1327124..1327187)) IV 1 NT_166523.1 Similarity: the ORF shows similarity to several glycine-rich proteins.; hypothetical protein 1327187 4981884 An07g06170 Aspergillus niger hypothetical protein XP_001391695.1 1326566 R 5061 CDS An07g06180 84591426 join(1327386..1327607,1327704..1327768,1328260..1328337,1328405..1328648) IV 1 NT_166523.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF; uncharacterized protein 1328648 84591426 An07g06180 Aspergillus niger uncharacterized protein XP_059605782.1 1327386 D 5061 CDS An07g06190 4981886 join(1328902..1331183,1331241..1331598) IV 1 NT_166523.1 Similarity: the ORF shows similarity to some proteins wird RING finger homology.; Title: similarity to hypothetical related to COP1-interacting protein CIP8 - Neurospora crassa; uncharacterized protein 1331598 4981886 An07g06190 Aspergillus niger uncharacterized protein XP_059605783.1 1328902 D 5061 CDS An07g06200 4981887 complement(join(1331864..1331945,1332037..1332173,1332249..1332267,1332315..1332333,1332475..1333301,1333364..1333932)) IV 1 NT_166523.1 Function: ccr4 of S. cerevisiae as a component of the major cytoplasmic mRNA deadenylase is required for the expression of a number of genes involved in nonfermentative growth, e. g. the control of ADH2 (glucose-repressible alcohol dehydrogenase) gene expression.; Induction: ccr4 of S. cerevisiae is, in contrast to that of many other activators, glucose regulated.; Phenotype: disruption of ccr4 in S. cerevisiae cells resulted in reduced levels of ADH2 expression under both glucose and ethanol growth conditions and in temperature sensitive growth on nonfermentative medium.; Remark: ccr4 of S. cerevisiae is also called YAL021C, FUN27 or nut21.; Similarity: the ORF shows only local similarity to ccr4 of S. cerevisiae, which is high in the inner leucin-rich region (amino acid 232 to 312) of the ORF.; Title: similarity to glucose-repressible transcriptional effector Ccr4 - Saccharomyces cerevisiae; See PMID 6392016; See PMID 8007957; See PMID 11239395; See PMID 2407614; uncharacterized protein 1333932 4981887 An07g06200 Aspergillus niger uncharacterized protein XP_001391698.3 1331864 R 5061 CDS An07g06210 84591427 complement(1334992..1335414) IV 1 NT_166523.1 hypothetical protein 1335414 84591427 An07g06210 Aspergillus niger hypothetical protein XP_059605784.1 1334992 R 5061 CDS An07g06220 84591428 join(1337168..1337180,1337221..1337495) IV 1 NT_166523.1 Remark: the ORF is questionable due to its short lenght of only 95 amino acids.; Title: questionable ORF; uncharacterized protein 1337495 84591428 An07g06220 Aspergillus niger uncharacterized protein XP_059605785.1 1337168 D 5061 CDS An07g06230 4981890 join(1338785..1339122,1339198..1339486,1339516..1339616,1339693..1339729) IV 1 NT_166523.1 hypothetical protein 1339729 4981890 An07g06230 Aspergillus niger hypothetical protein XP_059605786.1 1338785 D 5061 CDS An07g06240 4981891 complement(join(1339832..1340763,1340832..1341174,1341276..1341546,1341598..1341773)) IV 1 NT_166523.1 Function: sti1 of S. cerevisiae is a ferrioxamine B permease involved in siderophore (microbial iron chelators) iron transport.; Phenotype: S. cerevisiae cells with a deleted sti1 gene are unable to take up ferrioxamine B.; Remark: sit1 of S. cerevisiae is also called ARN3 or YEL065W.; Similarity: the ORF shows similarity to several major facilitator protein homologs from different species and with various specificities.; Title: strong similarity to ferrioxamine B permease Sit1 - Saccharomyces cerevisiae; endosome; See PMID 9884238; See PMID 10637361; See PMID 10744769; See PMID 11158346; uncharacterized protein 1341773 4981891 An07g06240 Aspergillus niger uncharacterized protein XP_001391702.1 1339832 R 5061 CDS An07g06250 84591429 complement(join(1342178..1342270,1342324..1342482,1342626..1342761,1342947..1342991,1343143..1343307,1343420..1343462,1343533..1343631,1343708..1343780)) IV 1 NT_166523.1 hypothetical protein 1343780 84591429 An07g06250 Aspergillus niger hypothetical protein XP_059605787.1 1342178 R 5061 CDS An07g06260 84591430 join(1344248..1344308,1344437..1344669) IV 1 NT_166523.1 hypothetical protein 1344669 84591430 An07g06260 Aspergillus niger hypothetical protein XP_059605788.1 1344248 D 5061 CDS An07g06270 4981894 complement(join(1344719..1344961,1345048..1345896)) IV 1 NT_166523.1 Title: similarity to hypothetical protein encoded by An04g09900 - Aspergillus niger; uncharacterized protein 1345896 4981894 An07g06270 Aspergillus niger uncharacterized protein XP_001391705.3 1344719 R 5061 CDS An07g06280 4981895 1347240..1347935 IV 1 NT_166523.1 Pathway: maiA of A. nidulans is a structural gene of the phenylalanine catabolic pathway.; Similarity: the MaiA protein and this protein show strong amino acid sequence identity to glutathione S-transferases.; Title: strong similarity to maleylacetoacetate isomerase maiA - Aspergillus nidulans; See PMID 9417084; uncharacterized protein 1347935 4981895 An07g06280 Aspergillus niger uncharacterized protein XP_001391706.1 1347240 D 5061 CDS An07g06290 84591431 complement(join(1349185..1349489,1349774..1349825)) IV 1 NT_166523.1 hypothetical protein 1349825 84591431 An07g06290 Aspergillus niger hypothetical protein XP_059605789.1 1349185 R 5061 CDS An07g06300 4981897 join(1350129..1350225,1350278..1350693,1350754..1351150,1351210..1351637,1351705..1351908) IV 1 NT_166523.1 Similarity: shows strong similarity to several fungal transporter proteins.; Title: strong similarity to member of the hexose transporter family of the major facilitator superfamily Hxt16 - Saccharomyces cerevisiae; plasma membrane; See PMID 8720066; See PMID 9348664; uncharacterized protein 1351908 4981897 An07g06300 Aspergillus niger uncharacterized protein XP_001391708.1 1350129 D 5061 CDS An07g06310 4981898 join(1352486..1352517,1352602..1352721,1352776..1352992,1353057..1353590,1353652..1353900,1353943..1354255,1354310..1354545) IV 1 NT_166523.1 Catalytic activity: L-sorbose dehydrogenase (SDH) and L-sorbosone dehydrogenase (SNDH) from Gluconobacter oxydans T-100 that showed an ability to convert D-sorbitol to 2-keto-L-gulonate.; Function: high-level production from D-sorbitol to 2-KLGA (130 mg/ml) was achieved by simple fermentation of the recombinant Gluconobacter.; Title: strong similarity to FAD dependent L-sorbose dehydrogenase SDH - Gluconobacter oxydans; See PMID 9023923; uncharacterized protein 1354545 4981898 An07g06310 Aspergillus niger uncharacterized protein XP_059605790.1 1352486 D 5061 CDS An07g06330 4981900 join(1355726..1355948,1356031..1356629) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein EAA58260.1 - Aspergillus nidulans; uncharacterized protein 1356629 4981900 An07g06330 Aspergillus niger uncharacterized protein XP_001391710.1 1355726 D 5061 CDS An07g06340 4981901 complement(join(1357202..1357325,1357415..1357505,1357558..1357587,1357642..1357668,1357755..1357809)) IV 1 NT_166523.1 Function: the patented proteins may be used to stimulate the growth and motility of keratinocytes, to inhibit the growth of cancer cells, to modulate angiogenesis and tumour vascularisation, to modulate skin inflammation, to modulate epithelial cell growth and to inhibit binding of HIV-1 to leukocytes.; Localization: contains no transmembranal domain,therefore not localized in membranes.; Remark: the patented sequences derived from rat dermal papilla, human keratinocytes and neonatal foreskin fibroblasts, and mouse embryonic skin, keratinocyte stem cells and transit amplifying cells.; Title: similarity to skin cell transmembrane protein from patent WO9955865-A1 - Rattus sp.; uncharacterized protein 1357809 4981901 An07g06340 Aspergillus niger uncharacterized protein XP_001391711.1 1357202 R 5061 CDS An07g06350 4981902 join(1358707..1359828,1359880..>1360743) IV 1 NT_166523.1 Remark: FHA is a putative nuclear signalling domain found in a variety of otherwise unrelated proteins.; Remark: the ORF is truncated due to border of contig.; Similarity: shows only partial similarity to aminoterminal part of S. pombe protein containing the FHA (Forkhead-associated) domain.; Title: similarity to hypothetical forkhead nuclear signaling protein SPBC3H7.13 - Schizosaccharomyces pombe [truncated ORF]; uncharacterized protein 1360743 4981902 An07g06350 Aspergillus niger uncharacterized protein XP_001391712.3 1358707 D 5061 CDS An07g06360 4981903 join(1361862..1361934,1361985..1362113,1362143..1362711,1362813..1363480,1363536..1363794) IV 1 NT_166523.1 Title: weak similarity to zinc finger II protein from patent WO200037629-A2 - Aspergillus terreus; uncharacterized protein 1363794 4981903 An07g06360 Aspergillus niger uncharacterized protein XP_059600962.1 1361862 D 5061 CDS An07g06370 4981904 complement(join(1364258..1364862,1364928..1365000)) IV 1 NT_166523.1 Similarity: the similarities are mainly based on repetetive structures.; Title: weak similarity to protease type 2 encoded by the gene iga1 - Haemophilus influenzae; uncharacterized protein 1365000 4981904 An07g06370 Aspergillus niger uncharacterized protein XP_001391714.1 1364258 R 5061 CDS An07g06380 4981905 complement(join(1365356..1366661,1366734..1367001,1367085..1367112)) IV 1 NT_166523.1 Similarity: the similarities are mainly based on repetetive structures.; Title: weak similarity to neurofilament triplet M protein - Mus musculus; uncharacterized protein 1367112 4981905 An07g06380 Aspergillus niger uncharacterized protein XP_001391715.3 1365356 R 5061 CDS An07g06390 4981906 complement(join(1367809..1367985,1368350..1368745)) IV 1 NT_166523.1 Similarity: show similarity to N-terminal fifth of An15g04750.; Title: weak similarity to hypothetical protein encoded by An15g04750 - Aspergillus niger; uncharacterized protein 1368745 4981906 An07g06390 Aspergillus niger uncharacterized protein XP_001391716.3 1367809 R 5061 CDS An07g06400 4981907 complement(join(1370522..1370923,1371053..1371678,1371728..1371892,1371940..1372750)) IV 1 NT_166523.1 Catalytic activity: RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).; Cofactor: copper and topequinone.; Complex: AO-I exists as a homodimer.; Induction: AO-I from A. niger is induced by N-butylamin.; Localization: AO-I is located in the cell wall and probably serves primarily as a detoxifying agent,preventing amines from entering and damaging the cell.; Remark: the AO-I aa sequence deviates significantly from the genomic sequence and therefore shows that two isoenzymes exist AO-I and AO-II.; Similarity: AO-I from A. niger belongs to a group of enzymes including those oxidizing primary monoamines,diamines and histamine.; Similarity: AO-I from A. niger belongs to the copper/topaquinone oxidase family.; Title: strong similarity to copper amine oxidase AO-I - Aspergillus niger; cell wall; See PMID 8620882; See PMID 10896215; uncharacterized protein 1372750 4981907 An07g06400 Aspergillus niger uncharacterized protein XP_001391717.1 1370522 R 5061 CDS An07g06410 84591432 join(1374964..1375053,1375144..1375236,1375325..1375486,1375610..1375820,1376029..1376077,1376164..1376215,1376508..1376665,1376745..1377056,1377171..1377251,1377344..1377527) IV 1 NT_166523.1 hypothetical protein 1377527 84591432 An07g06410 Aspergillus niger hypothetical protein XP_059600963.1 1374964 D 5061 CDS An07g06420 4981909 join(1378620..1379201,1379256..1380011) IV 1 NT_166523.1 Title: weak similarity to enhancer-binding protein C/EBP-delta - Mus musculus; uncharacterized protein 1380011 4981909 An07g06420 Aspergillus niger uncharacterized protein XP_001391719.3 1378620 D 5061 CDS An07g06430 4981910 join(1380989..1381137,1381200..1381553,1381611..1382439,1382488..1382748,1382811..1385705) IV 1 NT_166523.1 Function: Monoglucosylated structures may be formed by reglucosylation of Man7-9GlcNAc2 by the UDP-Glc:glycoprotein glucosyltransferase gpt1 from S. pombe.; Induction: Synthesis of the gpt1 mRNA from S. pombe was induced 2- to 9-fold by conditions known to affect glycoprotein folding in the ER.; Phenotype: the S. pombe gpt1 mutant lacks UDP-Glc:glycoprotein glucosyltransferase.; Title: strong similarity to glycoprotein glucosyltransferase gpt1p - Schizosaccharomyces pombe; endoplasmatic reticulum; See PMID 8631292; See PMID 9813085; uncharacterized protein 1385705 4981910 An07g06430 Aspergillus niger uncharacterized protein XP_001391720.1 1380989 D 5061 CDS An07g06440 84591433 join(1386391..1386671,1386757..>1386994) IV 1 NT_166523.1 Function: the matched protein of patent JP09009966-A from Acremonium chrysogenum, is involved in the biosynthesis of cephalosporin C.; Remark: about the patent is no further information available.; Title: strong similarity to protein involved in cephalosporin C biosynthesis from patent JP09009966-A -Acremonium chrysogenum [truncated ORF]; uncharacterized protein 1386994 84591433 An07g06440 Aspergillus niger uncharacterized protein XP_059600964.1 1386391 D 5061 CDS An07g06450 84591434 <1387127..1387591 IV 1 NT_166523.1 Function: the matched protein from A. chrysogenum is involved in the biosynthesis of cephalosporin C.; Remark: start codon is missing.; Title: strong similarity to protein involved in cephalosporin C biosynthesis from patent JP09009966-A -Acremonium chrysogenum [truncated ORF]; uncharacterized protein 1387591 84591434 An07g06450 Aspergillus niger uncharacterized protein XP_059600965.1 1387127 D 5061 CDS An07g06460 4981913 complement(join(1387677..1387771,1387844..1388079,1388146..1388230,1388289..1388376,1388434..1388838)) IV 1 NT_166523.1 Function: both enzymes from S. lactamdurans are required for cephem hydroxylation at C-7 and the transfer of the methyl group from S-adenosylmethionine to the 7-hydroxycephem intermediate.; Function: the C-7 hydroxycephem methyltransferase coupling protein from S. lactamdurans is encoded by ORF8 of a cephamycin biosynthetic enzyme gene cluster.; Function: the matched protein from S. lactamdurans acts as a coupling protein with the C-7 hydroxycephem methyltransferase, during the biosynthesis of cephamycin.; Remark: Nocardia lactamdurans = Streptomyces lactamdurans.; Title: similarity to C-7 hydroxycephem methyltransferase coupling protein from patent WO9529253-A1 - Streptomyces lactamdurans; uncharacterized protein 1388838 4981913 An07g06460 Aspergillus niger uncharacterized protein XP_001391723.1 1387677 R 5061 CDS An07g06470 84591435 join(1390011..1390124,1390755..1390848,1390941..1391029,1391118..1391297) IV 1 NT_166523.1 Title: weak similarity to neurofibromatosis type 1 NF1 - Mus musculus; uncharacterized protein 1391297 84591435 An07g06470 Aspergillus niger uncharacterized protein XP_059600966.1 1390011 D 5061 CDS An07g06480 4981915 complement(join(1392828..1392855,1392913..1393048,1393104..1394146,1394213..1394526)) IV 1 NT_166523.1 Catalytic activity: RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.; Function: recombinant cyp4F8 of H. sapiens oxygenated arachidonic acid to (18R)-hydroxyarachidonate.; Remark: belongs to the cytochrome P450 family.; Remark: cyp4F8 of H. sapiens is involved in prostaglandin synthesis.; Remark: the ORF shows similarity to several cytochromes.; Title: similarity to cytochrome 4F8 cyp4F8 - Homo sapiens; See PMID 10791960; uncharacterized protein 1394526 4981915 An07g06480 Aspergillus niger uncharacterized protein XP_059600967.1 1392828 R 5061 CDS An07g06490 4981916 join(1395257..1395505,1395587..1398083,1398158..1398525) IV 1 NT_166523.1 Function: IDE of R. norvegicus degrades insulin,glucagon, and other polypeptides.; Remark: IDE of R. norvegicus has also been implicated in the clearance of beta amyloid peptides. Thus,the enzyme may also be a candidate for an alternative gene therapeutic approach to the treatment of Alzheimer's disease.; Remark: IDE of R. norvegicus is also called insulysin, insulinase, and insulin protease.; Title: strong similarity to insulin-degrading enzyme IDE - Rattus norvegicus; See PMID 11102481; See PMID 11235899; uncharacterized protein 1398525 4981916 An07g06490 Aspergillus niger uncharacterized protein XP_059600968.1 1395257 D 5061 CDS An07g06500 4981917 complement(join(1398982..1398998,1399034..1399196,1399253..1399631,1399674..1400006,1400061..1400245)) IV 1 NT_166523.1 Function: SKY1 of S. cerevisiae, a serine/arginine-rich protein kinase, is a key regulator of polyamine transport and is involved in 3' splice site recognition upon interaction with Prp8 and Prp17/Slu4.; Similarity: the ORF is much shorter than SKY1 of S. cerevisiae (358 compared to 742 amin acids) and the similarity between the two proteins extends over a stretch of about 150 amino acids.; Title: similarity to SR protein kinase Sky1 -Saccharomyces cerevisiae; See PMID 11113192; See PMID 11565750; See PMID 11585720; uncharacterized protein 1400245 4981917 An07g06500 Aspergillus niger uncharacterized protein XP_059600969.1 1398982 R 5061 CDS An07g06510 4981918 complement(1401768..1402607) IV 1 NT_166523.1 Function: Rrp40 from S. cerevisiae is a component of the exosome complex responsible for 3' end processing and degradation of many RNA species.; Function: Rrp40 from S. cerevisiae is involved in rRNA processing.; Remark: the synonym for Rrp40 from S. cerevisiae is YOL142w.; Title: strong similarity to protein involved in ribosomal RNA processing Rrp40 - Saccharomyces cerevisiae; nucleus; See PMID 10465791; See PMID 9778798; uncharacterized protein 1402607 4981918 An07g06510 Aspergillus niger uncharacterized protein XP_001391728.1 1401768 R 5061 CDS An07g06520 4981919 join(1403156..1403245,1403352..1403388,1403453..1403579,1403635..1404406,1404458..1405132) IV 1 NT_166523.1 Function: pdr13 of S. cerevisiae probably influences pleiotropic drug resistance by enhancing the function of the transcriptional regulatory protein Pdr1p, which regulates the expression of several multi-drug resistance transporter-encoding genes.; Similarity: the ORF shows simlarity to several hsp70 homologs with various substrate specificities.; Title: strong similarity to heat shock protein 70 homolog Pdr13 - Saccharomyces cerevisiae; See PMID 11395418; See PMID 9488429; uncharacterized protein 1405132 4981919 An07g06520 Aspergillus niger uncharacterized protein XP_001391729.1 1403156 D 5061 CDS An07g06530 4981920 complement(join(1406480..1406726,1406777..1406959,1407020..1407317,1407391..1407403)) IV 1 NT_166523.1 Function: sur7 of S. cerevisiae probably acts in relation with rvs161 and rvs167, two proteins involved in budding and actin skeleton morphology.; Phenotype: when sur7 is overexpressed in S. cerevisiae it suppresses the reduced viability upon carbon starvation of the rvs167 mutant strain.; Remark: sur7 of S. cerevisiae is also called YML052W or YM9958. 11.; Similarity: the similarity to sur7 of S. cerevisiae is restricted to the N-terminal regions, ending with amino acid 189 of the ORF.; Title: strong similarity to multicopy suppressor Sur7 - Saccharomyces cerevisiae; See PMID 9219339; uncharacterized protein 1407403 4981920 An07g06530 Aspergillus niger uncharacterized protein XP_001391730.1 1406480 R 5061 CDS An07g06535 4981921 join(1408222..1408287,1408407..1408592,1408728..1409030,1409090..1409473) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein EAA60416.1 - Aspergillus nidulans; uncharacterized protein 1409473 4981921 An07g06535 Aspergillus niger uncharacterized protein XP_001391731.1 1408222 D 5061 CDS An07g06540 4981922 1409763..1412339 IV 1 NT_166523.1 Similarity: the predicted ORF is twice as long as the putative S. pombe protein.; Title: strong similarity to hypothetical cytochrome c oxidase assembly protein SPAC1420.04c -Schizosaccharomyces pombe; uncharacterized protein 1412339 4981922 An07g06540 Aspergillus niger uncharacterized protein XP_001391732.1 1409763 D 5061 CDS An07g06550 4981923 complement(join(1413034..1413414,1413463..1413594)) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein EAA60414.1 - Aspergillus nidulans; uncharacterized protein 1413594 4981923 An07g06550 Aspergillus niger uncharacterized protein XP_001391733.1 1413034 R 5061 CDS An07g06560 4981924 join(1413888..1413924,1414003..1414032,1414166..1414216,1414340..1414395) IV 1 NT_166523.1 Function: mitochondrial ATP synthase chain j of S. pombe is one of the chains of the non-enzymatic component (CF(0) subunit) of the mitochondrial ATPase complex.; Similarity: the ORF overlaps with A: niger ESTs EMBLEST:BE759173 and EMBLEST:BE760809.; Title: strong similarity to mitochondrial ATP synthase chain j - Schizosaccharomyces pombe; localisation:mitochondrion; See PMID 9867807; uncharacterized protein 1414395 4981924 An07g06560 Aspergillus niger uncharacterized protein XP_001391734.1 1413888 D 5061 CDS An07g06570 4981925 join(1415277..1415383,1415450..1415621,1415684..1415746) IV 1 NT_166523.1 Remark: mrp2 of S. cerevisiae is also called P9325. 7 or YPR166c.; Similarity: the ORF overlaps with A. niger EST EMBLEST:BE759438.; Title: strong similarity to mitochondrial ribosomal protein of the small subunit S14 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 770043; See PMID 8265368; mitochondrial 37S ribosomal protein uS14m 1415746 4981925 An07g06570 Aspergillus niger mitochondrial 37S ribosomal protein uS14m XP_001391735.1 1415277 D 5061 CDS An07g06580 4981926 join(1416304..1416371,1416429..1416544,1416598..1417149,1417219..1417619) IV 1 NT_166523.1 Similarity: the predicted ORF is 112 amino acids longer than the hypothetical protein from S. pombe.; Title: similarity to hypothetical protein SPAC13G7.07 - Schizosaccharomyces pombe; uncharacterized protein 1417619 4981926 An07g06580 Aspergillus niger uncharacterized protein XP_001391736.1 1416304 D 5061 CDS An07g06590 4981927 complement(join(1417760..1418458,1418536..1418796)) IV 1 NT_166523.1 Function: vph2 of S. cerevisiae is involved in vacuolar acidification probably by promoting the assembly of vacuolar H(+)-ATPase.; Phenotype: the null mutant of vph2 in S. cerevisiae is viable, zinc sensitive, defective in vacuolar acidification, calcium-sensitive and respiratory deficient.; Remark: vph2 of S. cerevisiae is also called vma12,cls1, YKL119c or YKL520.; Similarity: the similarity to vph2 of S. cerevisiae is locally high in the inner region of the ORF, which is homologues to the C-terminal part of vph2 (transmembrane domain), starting with amino acid 110.; Title: similarity to vacuolar H+-transporting ATPase assembly protein Vph2 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 8465604; uncharacterized protein 1418796 4981927 An07g06590 Aspergillus niger uncharacterized protein XP_001391737.1 1417760 R 5061 CDS An07g06600 4981928 join(1419381..1419737,1419796..1419900) IV 1 NT_166523.1 Function: prefoldin is a heterohexameric chaperone protein able to bind specifically to cytosolic chaperonin (c-cpn) and transfers target proteins to it.; Phenotype: deletion of the pfd3 gene in S. cerevisiae results in impaired functions of the actin and tue actin and tubulin-based cytoskeleton.; Remark: synonyms for prefoldin subunit 3 pfd3 of H. sapiens are von Hippel-Lindau binding protein 1, VHL binding protein-1, VBP-1 and HIBBJ46.; Title: strong similarity to prefoldin subunit 3 pfd3 - Homo sapiens; uncharacterized protein 1419900 4981928 An07g06600 Aspergillus niger uncharacterized protein XP_001391738.3 1419381 D 5061 CDS An07g06610 4981929 complement(join(1420390..1422785,1422978..1423236,1423287..1424522)) IV 1 NT_166523.1 Catalytic activity: UDP-glucose:sterol glucosyltransferases convert UDP-glucose + a sterol <=> UDP + an O-glucosylsterol.; Similarity: the ORF overlaps with A. niger EST EMBLEST:BE760047.; Title: strong similarity to UDP-glucose:sterol glucosyltransferase UGT51B1 - Pichia pastoris; uncharacterized protein 1424522 4981929 An07g06610 Aspergillus niger uncharacterized protein XP_059600970.1 1420390 R 5061 CDS An07g06615 84591436 complement(join(1424762..1424779,1424893..1425169,1425239..1425306)) IV 1 NT_166523.1 hypothetical protein 1425306 84591436 An07g06615 Aspergillus niger hypothetical protein XP_059600971.1 1424762 R 5061 CDS An07g06630 4981931 complement(join(1426208..1426970,1427033..1427199)) IV 1 NT_166523.1 Similarity: the predicted oRF shows similarity to proteins containing serine or lysine-rich stretches.; hypothetical protein 1427199 4981931 An07g06630 Aspergillus niger hypothetical protein XP_001391741.1 1426208 R 5061 CDS An07g06640 4981932 join(1427579..1427612,1427667..1428066,1428117..1428243,1428292..1428603,1428662..1429216,1429269..1430246) IV 1 NT_166523.1 Similarity: the ORF shows also strong similarity to the homologues hypothetical protein in yeast, YLL035w of S. cerevisiae and the region with highest homology (around amino acid 300 to 440) is similar to the product of M. musculus neonate skin cDNA (clone:4632412I24) and a hypothetical protein T30N20_280 of A. thaliana (includes a small part of sequence block IPB001482B).; Title: strong similarity to hypothetical protein SPCC830.03 - Schizosaccharomyces pombe; uncharacterized protein 1430246 4981932 An07g06640 Aspergillus niger uncharacterized protein XP_001391742.1 1427579 D 5061 CDS An07g06650 84591437 join(<1430925..1431208,1431331..1431388) IV 1 NT_166523.1 Catalytic activity: 3-oxoacyl-acyl carrier protein reductases convert (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP(+) <=> 3-oxoacyl-[acyl-carrier protein] + NADPH.; Catalytic activity: acetoacetyl-CoA reductases convert (R)-3-hydroxyacyl-CoA + NADP(+) <=> 3-oxoacyl-CoA + NADPH.; Function: 3-oxoacyl-acyl carrier protein reductases show preference for acyl-carrier protein derivatives over CoA derivatives as substrates.; Function: acetoacetyl-CoA reductases and 3-oxoacyl-acyl carrier protein reductases function in the distinct steps of the fatty-acid biosynthesis.; Remark: the predicted ORF is probably N-terminally truncated, the homology of the rest sequence to several oxidoreductases from bacteria is high and speaks in favour for an 130 to 140 longer N-terminus.; Similarity: the ORF shows similarity to acetoacetyl-CoA reductases and 3-oxoacyl-acyl carrier protein reductases from different species.; Title: similarity to acetoacetyl-CoA reductase phbB - Zoogloea ramigera [truncated ORF]; uncharacterized protein 1431388 84591437 An07g06650 Aspergillus niger uncharacterized protein XP_059600972.1 1430925 D 5061 CDS An07g06670 84591438 complement(join(1432430..1432486,1432556..1432696)) IV 1 NT_166523.1 Similarity: because the predicted ORF is of a short length, 65 aa, the similarity extends only over the C-terminal region of An04g09660 of A. niger.; Title: strong similarity to hypothetical protein encoded by An04g09660 - Aspergillus niger; uncharacterized protein 1432696 84591438 An07g06670 Aspergillus niger uncharacterized protein XP_059600973.1 1432430 R 5061 CDS An07g06680 84591439 join(1435033..1435415,1435533..1435638) IV 1 NT_166523.1 hypothetical protein 1435638 84591439 An07g06680 Aspergillus niger hypothetical protein XP_059600974.1 1435033 D 5061 CDS An07g06690 84591440 join(1436745..1436861,1436962..1437024,1437141..1437404) IV 1 NT_166523.1 hypothetical protein 1437404 84591440 An07g06690 Aspergillus niger hypothetical protein XP_059600975.1 1436745 D 5061 CDS An07g06700 4981938 join(1437784..1437818,1437939..1438083,1438147..1438179,1438224..1438469,1438976..1439005,1439320..1440684) IV 1 NT_166523.1 Similarity: the predicted ORF is 160 amino acids longer at the N-terminus than the N. crassa protein.; Title: similarity to hypothetical protein CAF05888.1 - Neurospora crassa; uncharacterized protein 1440684 4981938 An07g06700 Aspergillus niger uncharacterized protein XP_001391747.3 1437784 D 5061 CDS An07g06710 84591441 complement(join(1442414..1442656,1442688..1442699)) IV 1 NT_166523.1 Remark: the ORF might be questionable due to its short lenght of only 84 amino acids.; Title: weak similarity to hypothetical protein AAM43672.1 - Dictyostelium discoideum; uncharacterized protein 1442699 84591441 An07g06710 Aspergillus niger uncharacterized protein XP_059600976.1 1442414 R 5061 CDS An07g06720 84591442 complement(join(1443476..1443906,1444020..1444351,1444407..1444670,1444730..1444988,1445041..1445083)) IV 1 NT_166523.1 Title: similarity to hypothetical protein CAE76294.1 - Neurospora crassa; uncharacterized protein 1445083 84591442 An07g06720 Aspergillus niger uncharacterized protein XP_059600977.1 1443476 R 5061 CDS An07g06730 4981941 complement(join(1447293..1447388,1447444..1447521,1447572..1448324,1448377..1451379)) IV 1 NT_166523.1 Complex: cut3/SMC4 of S. pombe is a subunit of the SMC (structural maintenance of chromosomes) complex. SMC and non-SMC subunits form the condensin complex, which has supercoiling activity.; Function: cut3/SMC4 of S. pombe is involved in chromosome condensation.; Similarity: the predicted protein shows strong similarity to cut3/SMC4 of S. pombe, human hCAP-C (chromosome-associated polypeptide-C) and related proteins from diverse eucaryotic species.; Title: strong similarity to cut3p -Schizosaccharomyces pombe; nucleus; See PMID 7957061; See PMID 9285594; See PMID 10485849; uncharacterized protein 1451379 4981941 An07g06730 Aspergillus niger uncharacterized protein XP_001391750.3 1447293 R 5061 CDS An07g06740 4981942 join(1452040..1452227,1452278..1452485,1452544..1453113) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein EAA60398.1 - Aspergillus nidulans; uncharacterized protein 1453113 4981942 An07g06740 Aspergillus niger uncharacterized protein XP_059600978.1 1452040 D 5061 CDS An07g06750 4981943 join(1453706..1453751,1453830..1453913,1454130..1454160,1454215..1454490,1454527..1455715) IV 1 NT_166523.1 Function: Rat7 from S. cerevisiae may play a direct role in nucleocytoplasmic export of RNA.; Remark: Rat7 from S. cerevisiae is located at the nuclear rim in a punctate pattern characteristic of nucleoporins.; Remark: alternate names for Rat7 from S. cerevisiae are NUP158 and YIL115c.; Title: similarity to repeat-containing nucleoporin Rat7 - Saccharomyces cerevisiae; See PMID 7744966; uncharacterized protein 1455715 4981943 An07g06750 Aspergillus niger uncharacterized protein XP_059600979.1 1453706 D 5061 CDS An07g06760 4981944 complement(join(1456110..1456194,1456266..1456489,1456621..1456662)) IV 1 NT_166523.1 Remark: a splice site was detected upstream of the START codon.; Remark: ribosomal protein S20 of S. cerevisiae is encoded by gene RPS20 also known as URP2 and YHL015W.; Similarity: belongs to the s10p family of ribosomal proteins; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S20 - Saccharomyces cerevisiae; cytoplasm; See PMID 8021936; 40S ribosomal protein uS10 1456662 4981944 An07g06760 Aspergillus niger 40S ribosomal protein uS10 XP_001391753.3 1456110 R 5061 CDS An07g06770 4981945 complement(join(1457800..1459267,1459339..1459544)) IV 1 NT_166523.1 Function: involved in gamma-linolenic acid synthesis; Title: strong similarity to delta-6 desaturase -Mucor rouxii; See PMID 11112411; uncharacterized protein 1459544 4981945 An07g06770 Aspergillus niger uncharacterized protein XP_001391754.1 1457800 R 5061 CDS An07g06780 4981946 join(1460174..1460194,1460305..1460349,1460512..1460590,1460691..1461010,1461063..1461085,1461204..1461384,1461435..1461724,1461775..1462451,1462504..1462664) IV 1 NT_166523.1 Catalytic activity: D-mannose 1-phosphate = D-mannose 6-phosphate; Similarity: to other phosphoglucomutases and phosphomannomutases; Title: strong similarity to hypothetical phosphomannomutase homolog - Schizosaccharomyces pombe; See PMID 1903398; uncharacterized protein 1462664 4981946 An07g06780 Aspergillus niger uncharacterized protein XP_059600980.1 1460174 D 5061 CDS An07g06790 84591443 complement(join(1462868..1462968,1463057..1463140,1463224..1463387,1463498..1463529)) IV 1 NT_166523.1 hypothetical protein 1463529 84591443 An07g06790 Aspergillus niger hypothetical protein XP_059600981.1 1462868 R 5061 CDS An07g06800 4981948 join(1463923..1463955,1464021..1465283,1465313..1465357,1465447..1465463,1465593..1465923) IV 1 NT_166523.1 Catalytic activity: salicylate + NADH + O2 = catechol + NAD+ + H2O + CO2.; Function: nahG of P. putida catalyzes the formation of catechol from salicylate, a key intermediate in naphthalene catabolism.; Pathway: nahpthalene catabolism and phenylalanine metabolism.; Title: similarity to salicylate hydroxylase nahG -Pseudomonas putida; See PMID 1993181; See PMID 2363715; uncharacterized protein 1465923 4981948 An07g06800 Aspergillus niger uncharacterized protein XP_059600982.1 1463923 D 5061 CDS An07g06810 84591444 join(1466392..1466554,1466607..1466689,1466737..1466828,1467152..1467293) IV 1 NT_166523.1 hypothetical protein 1467293 84591444 An07g06810 Aspergillus niger hypothetical protein XP_059600983.1 1466392 D 5061 CDS An07g06820 4981950 join(1467440..1467487,1467574..1467825,1467928..1468207,1468291..1468445,1468575..1468634) IV 1 NT_166523.1 Remark: the unknown dehydrogenase from Xanthobacter is capable of complementation of Xanthobacter Py2 mutants in epoxyalkane degradation; Title: strong similarity to hypothetical dehydrogenase - Xanthobacter sp.; uncharacterized protein 1468634 4981950 An07g06820 Aspergillus niger uncharacterized protein XP_059600984.1 1467440 D 5061 CDS An07g06840 4981952 complement(join(1469378..1470217,1470299..1470781,1470849..1470928,1471028..1471169)) IV 1 NT_166523.1 Catalytic activity: dihydrolipoamide + NAD(+) = lipoamide + NADH; Complex: LPD1 of S. cerevisiae exists as a homodimer linked by one disulfide bond.; Function: lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes; Localization: LPD1 of S. cerevisiae has a potential transit peptide targeting it to the mitochondrion.; Phenotype: a recessive mutation in the LPD1 gene of S. cerevisiae leads to an inability to utilize glycerol or acetate as a carbon source and also an inability to sporulate.; Remark: in S. cervisiae LPD1 is also known as HPD1 and YFL018C.; Similarity: belongs to the pyridine nucleotide-disulfide oxidoreductases class-I; Title: strong similarity to precursor of dihydrolipoamide dehydrogenase Lpd1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 6404748; See PMID 2821168; See PMID 3058861; See PMID 3279419; See PMID 3528755; uncharacterized protein 1471169 4981952 An07g06840 Aspergillus niger uncharacterized protein XP_001391760.1 1469378 R 5061 CDS An07g06850 84591445 complement(join(1471413..1471634,1471705..1471782,1471827..1471970)) IV 1 NT_166523.1 hypothetical protein 1471970 84591445 An07g06850 Aspergillus niger hypothetical protein XP_059600985.1 1471413 R 5061 CDS An07g06860 84591446 join(1472118..1472217,1473164..1473210,1473284..1473457) IV 1 NT_166523.1 Title: questionable ORF; uncharacterized protein 1473457 84591446 An07g06860 Aspergillus niger uncharacterized protein XP_059600986.1 1472118 D 5061 CDS An07g06870 84591447 complement(join(1473682..1473765,1473826..1473933,1473958..1474215)) IV 1 NT_166523.1 hypothetical protein 1474215 84591447 An07g06870 Aspergillus niger hypothetical protein XP_059600987.1 1473682 R 5061 CDS An07g06880 4981956 join(1474496..1474892,1474944..1475097,1475142..1475533,1475583..1475665,1475710..1475938,1475992..1476089,1476139..1476405,1476460..1476495) IV 1 NT_166523.1 Remark: disruption of STL1 had no detectable effect on yeast growth on glucose, galactose, mannose, maltose or glycerol as sole carbon source.; Similarity: belongs to the sugar transporter family.; Title: strong similarity to sugar transport protein Stl1 - Saccharomyces cerevisiae; See PMID 8076821; uncharacterized protein 1476495 4981956 An07g06880 Aspergillus niger uncharacterized protein XP_001391764.1 1474496 D 5061 CDS An07g06900 84591448 complement(join(1477411..1477787,1477863..1478323,1478378..1478529,1478590..1478700)) IV 1 NT_166523.1 Title: similarity to hypothetical protein CAD70537.1 - Neurospora crassa; uncharacterized protein 1478700 84591448 An07g06900 Aspergillus niger uncharacterized protein XP_059600988.1 1477411 R 5061 CDS An07g06910 4981959 1479676..1480518 IV 1 NT_166523.1 Title: similarity to hypothetical protein encoded by An01g09070 - Aspergillus niger; uncharacterized protein 1480518 4981959 An07g06910 Aspergillus niger uncharacterized protein XP_001391766.1 1479676 D 5061 CDS An07g06920 84591449 complement(join(1481418..1482719,1482777..1482905,1482967..1483311)) IV 1 NT_166523.1 Title: similarity to hypothetical protein encoded by An07g06900 - Aspergillus niger; uncharacterized protein 1483311 84591449 An07g06920 Aspergillus niger uncharacterized protein XP_059600989.1 1481418 R 5061 CDS An07g06930 84591450 complement(join(1483605..1483764,1484711..1484835)) IV 1 NT_166523.1 Title: questionable ORF; uncharacterized protein 1484835 84591450 An07g06930 Aspergillus niger uncharacterized protein XP_059600990.1 1483605 R 5061 CDS An07g06940 84591451 complement(1485344..1486426) IV 1 NT_166523.1 Title: similarity to hypothetical protein encoded by An03g00300 - Aspergillus niger; uncharacterized protein 1486426 84591451 An07g06940 Aspergillus niger uncharacterized protein XP_059600991.1 1485344 R 5061 CDS An07g06960 4981964 complement(join(1487268..1487418,1487559..1487610,1487647..1488280)) IV 1 NT_166523.1 Title: similarity to hypothetical protein SMb20606 -Sinorhizobium meliloti; uncharacterized protein 1488280 4981964 An07g06960 Aspergillus niger uncharacterized protein XP_001391770.3 1487268 R 5061 CDS An07g06970 84591452 complement(join(1488626..1488686,1488740..1488934,1489030..1489112,1489252..1489632)) IV 1 NT_166523.1 hypothetical protein 1489632 84591452 An07g06970 Aspergillus niger hypothetical protein XP_059600992.1 1488626 R 5061 CDS An07g06980 4981966 complement(join(1490134..1490923,1490970..1491106,1491157..1491479,1491527..1491696,1491750..1491928,1491993..1492193,1492265..1492354)) IV 1 NT_166523.1 Catalytic activity: ATP-independent breakage of single-stranded DNA,followed by passage and rejoining; Function: reduces the number of supercoils in a highly negatively supercoiled DNA; Similarity: belongs to prokaryotic type I/III topoisomerase family; Title: strong similarity to DNA topoisomerase III -Schizosaccharomyces pombe; uncharacterized protein 1492354 4981966 An07g06980 Aspergillus niger uncharacterized protein XP_001391772.1 1490134 R 5061 CDS An07g06990 4981967 join(1492798..1493169,1493223..1493972) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein SPCC594.04c - Schizosaccharomyces pombe; uncharacterized protein 1493972 4981967 An07g06990 Aspergillus niger uncharacterized protein XP_001391773.1 1492798 D 5061 CDS An07g07000 4981968 complement(join(1494699..1495480,1495555..1497469)) IV 1 NT_166523.1 Function: independent of its proteolytic function, a chaperone-like activity of the Yta10-12 complex is required for assembly of the membrane-associated ATP synthase.; Function: the S. cerevisiae homolog Yty12p is subunit of the mitochondrial Yta10-12 complex m-AAA protease, which mediates the degradation of nonassembled inner membrane proteins. in contrast to nucleotide-dependent complex formation and substrate binding, proteolysis of bound polypeptides depends on the hydrolysis of ATP and the metallopeptidase activity of both subunits.; Remark: YTA12 of S. cerevisiae is also called RCA1 or YMR089C.; Remark: mutations in YTA12 of S. cerevisiae cause a mitochondrial respiratory deficiency as a result of a pleotropic defect in assembly of the respiratory chain and ATPase complexes.; Title: strong similarity to mitochondrial m-AAA protease subunit Yta12 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 7929327; See PMID 11309190; uncharacterized protein 1497469 4981968 An07g07000 Aspergillus niger uncharacterized protein XP_001391774.1 1494699 R 5061 CDS An07g07010 4981969 complement(join(1498282..1498744,1498797..1498901,1498982..1498986)) IV 1 NT_166523.1 Function: ribosomal protein L24 interacts with the 5. 8 S rRNA of S. cerevisiae.; Phenotype: S. cerevisiae mutants lacking L24 shows just 25% of the normal polyphenylalanine-synthesizing activity followed by a decrease in P-site binding,suggesting the possibility that protein L24 is involved in the kinetics of translation.; Title: strong similarity to hypothetical ribosomal protein of the large subunit L24 YLR009w - Saccharomyces cerevisiae; cytoplasm; See PMID 6337137; See PMID 10852723; uncharacterized protein 1498986 4981969 An07g07010 Aspergillus niger uncharacterized protein XP_059600993.1 1498282 R 5061 CDS An07g07020 4981970 join(1499316..1499363,1499439..1499512,1499571..1499624,1499685..1499823) IV 1 NT_166523.1 Similarity: the ORF overlaps with A. niger EST EMBLEST:AN755.; Similarity: the ORF shows similarity to several proteins with a DNA-J motive, which is found in some heat-shock proteins.; Title: strong similarity to methylation-controlled DNAJ-like protein mcj - Homo sapiens; See PMID 11358853; uncharacterized protein 1499823 4981970 An07g07020 Aspergillus niger uncharacterized protein XP_001391776.1 1499316 D 5061 CDS An07g07030 84591453 1500525..1500866 IV 1 NT_166523.1 Remark: the ORF is questionable due to its short lenght of only 113 amino acids.; Title: questionable ORF; uncharacterized protein 1500866 84591453 An07g07030 Aspergillus niger uncharacterized protein XP_059600994.1 1500525 D 5061 CDS An07g07040 84591454 complement(join(1501417..1501555,1501603..1501706)) IV 1 NT_166523.1 Remark: the ORF is questionable due to its short lenght of only 80 amino acids.; Title: questionable ORF; uncharacterized protein 1501706 84591454 An07g07040 Aspergillus niger uncharacterized protein XP_059600995.1 1501417 R 5061 CDS An07g07050 4981973 join(1501811..1502011,1502087..1502214,1502280..1502659,1502711..1503207,1503268..1503443,1503496..1504056,1504108..1504858) IV 1 NT_166523.1 Function: the facB gene of A. niger is probably a regulatory gene involved in acetamide and acetate utilisation.; Phenotype: deletion of the facB gene in A. niger confirmed that it is required for growth on acetate as a sole carbon source.; Similarity: the ORF shows similarity to several zinc finger transcription regulator proteins from different species and with various functions.; Title: strong similarity to acetate regulatory DNA binding protein facB - Aspergillus niger; See PMID 9197408; See PMID 10483720; uncharacterized protein 1504858 4981973 An07g07050 Aspergillus niger uncharacterized protein XP_001391779.1 1501811 D 5061 CDS An07g07060 4981974 complement(join(1506148..1506985,1507164..1507705,1507818..1507832)) IV 1 NT_166523.1 Similarity: the ORF is 3200 amino acids shorter than the putative H. sapiens transcription factor.; Title: strong similarity to hypothetical protein EAA60885.1 - Aspergillus nidulans; uncharacterized protein 1507832 4981974 An07g07060 Aspergillus niger uncharacterized protein XP_001391780.1 1506148 R 5061 CDS An07g07070 84591455 join(1509885..1509994,1510076..1510135,1510191..1510350) IV 1 NT_166523.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF; uncharacterized protein 1510350 84591455 An07g07070 Aspergillus niger uncharacterized protein XP_059600996.1 1509885 D 5061 CDS An07g07080 84591456 complement(join(1510455..1510510,1510578..1510815,1510926..1511004,1511147..1511212,1511302..1511417)) IV 1 NT_166523.1 hypothetical protein 1511417 84591456 An07g07080 Aspergillus niger hypothetical protein XP_059600997.1 1510455 R 5061 CDS An07g07090 4981977 join(1511697..1512189,1512258..1512805) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein 17E5.330 - Neurospora crassa; uncharacterized protein 1512805 4981977 An07g07090 Aspergillus niger uncharacterized protein XP_001391783.1 1511697 D 5061 CDS An07g07100 4981978 complement(join(1512971..1513958,1514164..1514222)) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein YIL064w - Saccharomyces cerevisiae; uncharacterized protein 1514222 4981978 An07g07100 Aspergillus niger uncharacterized protein XP_001391784.1 1512971 R 5061 CDS An07g07110 84591457 complement(join(1514971..1515885,1516024..1517106)) IV 1 NT_166523.1 Function: pmp1 of S. pombe has an essential function in Cl- homeostasis, cytokinesis and cell viability.; Function: pmp1 phosphatase dephosphorylates pmk1,the third MAP kinase in fission yeast, in vitro and in vivo, and is bound to pmk1 in vivo, strongly suggesting that pmp1 negatively regulates pmk1 MAP kinase by direct dephosphorylation.; Similarity: the ORF shows similarity to several dual specificity phosphatases from different species and with various function.; Title: strong similarity to dual-specificity phosphatase mp1p - Schizosaccharomyces pombe; uncharacterized protein 1517106 84591457 An07g07110 Aspergillus niger uncharacterized protein XP_059600998.1 1514971 R 5061 CDS An07g07120 84591458 join(1517309..1517336,1517438..1517569,1517766..1517990,1518209..1518300,1518535..1518593,1518677..1518843,1518925..1518980,1519178..1519225,1519297..1519358,1519529..1519658,1519884..1519925,1520127..1520186) IV 1 NT_166523.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF; uncharacterized protein 1520186 84591458 An07g07120 Aspergillus niger uncharacterized protein XP_059600999.1 1517309 D 5061 CDS An07g07130 84591459 complement(join(1520341..1520376,1520515..1520766,1520796..1520885)) IV 1 NT_166523.1 hypothetical protein 1520885 84591459 An07g07130 Aspergillus niger hypothetical protein XP_059601000.1 1520341 R 5061 CDS An07g07140 4981982 <1525358..1526848 IV 1 NT_166523.1 Remark: ORF 5'truncated due to end of contig.; Remark: blastp with the predicted A. niger protein only retrieves random hits to serine rich proteins.; hypothetical protein [truncated ORF] 1526848 4981982 An07g07140 Aspergillus niger hypothetical protein [truncated ORF] XP_001391788.3 1525358 D 5061 CDS An07g07150 4981983 complement(join(1529046..1529740,1529808..1530195)) IV 1 NT_166523.1 Complex: five proteins interact with mCBP in the yeast two hybrid system; mouse y-box protein 1 (msy-1),y-box-binding protein, hnRNP-L, filamin and splicing factor 9G8.; Function: mouse CBP is a single-stranded nucleic acid binding protein implicated in RNA-metabolism.; Localization: mouse CBP is found predominantly in the nucleus with the exception of the nucleoli.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_3405 and 2579 .; Title: strong similarity to single-stranded nucleic acid binding protein CBP - Mus musculus; nucleus; See PMID 8208614; See PMID 8871564; uncharacterized protein 1530195 4981983 An07g07150 Aspergillus niger uncharacterized protein XP_001391789.1 1529046 R 5061 CDS An07g07160 4981984 complement(join(1531266..1531368,1531444..1531565,1531623..1532087,1532163..1532259,1532377..1532523,1532582..1532718)) IV 1 NT_166523.1 Catalytic activity: P. putida fdm catalyzes the dismutation of formaldehyde to form methanol and formic acid at the ratio of 1:1 in the absence of the exogenous electron acceptor, NAD(H).; Function: P. putida fdm is required for formaldehyde biodegradation.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger EST an_1690 .; Similarity: the predicted A. niger protein shows strong similarity to several putative glutathione-dependent formaldehyde dehydrogenases.; Title: similarity to formaldehyde dismutase fdm -Pseudomonas putida; See PMID 7766017; uncharacterized protein 1532718 4981984 An07g07160 Aspergillus niger uncharacterized protein XP_001391790.1 1531266 R 5061 CDS An07g07170 4981985 complement(join(1533965..1534198,1534266..1534364)) IV 1 NT_166523.1 Complex: in a two-hybrid screen D. melanogaster yippee was physically interacting with Hyalophora cecropia Hemolin, a bacteria-induced insect immunoglobulin, D. melanogster Rpn11, spen, yip2, 3, 4, 6 and 7.; Title: strong similarity to Yippee - Drosophila melanogaster; See PMID 11240639; uncharacterized protein 1534364 4981985 An07g07170 Aspergillus niger uncharacterized protein XP_001391791.1 1533965 R 5061 CDS An07g07180 4981986 complement(join(1535222..1535275,1535363..1535460,1535710..1535740,1535844..1535883,1536391..1537769)) IV 1 NT_166523.1 Remark: blastp with the predicted A. niger protein only retrieves random hits to serine rich proteins.; hypothetical protein 1537769 4981986 An07g07180 Aspergillus niger hypothetical protein XP_001391792.3 1535222 R 5061 CDS An07g07190 4981987 join(1538193..1538215,1538274..1538391,1538443..1538601,1538669..1539186,1539238..1539380,1539435..1540612) IV 1 NT_166523.1 Title: strong similarity to polypeptide SEQ ID NO:41748 from patent WO200171042-A2 - Drosophila melanogaster; uncharacterized protein 1540612 4981987 An07g07190 Aspergillus niger uncharacterized protein XP_001391793.1 1538193 D 5061 CDS An07g07200 84591460 complement(join(1542306..1542395,1542489..1542542,1542601..1542650,1542718..1542813,1543068..1543098)) IV 1 NT_166523.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1543098 84591460 An07g07200 Aspergillus niger uncharacterized protein XP_059606913.1 1542306 R 5061 CDS An07g07210 4981989 join(1543182..1543209,1543273..1543494,1543626..1543773,1543879..1546796,1546849..1547117) IV 1 NT_166523.1 Function: S. cerevisiae PEX15 is required for peroxisome biogenesis.; Localization: S. cerevisiae PEX15 is an integral peroxisomal membrane protein.; Remark: alternative names for S. cerevisiae PEX15 are PAS21 and YOL044w.; Similarity: similarity is from the C-terminal region of the predicted A. niger protein to S. cerevisiae PEX15,which is 800 aa shorter.; Similarity: the predicted A. niger protein shows similarity to several predicted serine/threonine kinases.; Title: similarity to peroxisome assembly factor Pex15 - Saccharomyces cerevisiae; deleted EC_number 2.7.1.37; peroxisome; See PMID 9405362; uncharacterized protein 1547117 4981989 An07g07210 Aspergillus niger uncharacterized protein XP_059606914.1 1543182 D 5061 CDS An07g07220 84591461 complement(join(1547673..1547708,1547828..1547914)) IV 1 NT_166523.1 Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1547914 84591461 An07g07220 Aspergillus niger uncharacterized protein XP_059606915.1 1547673 R 5061 CDS An07g07230 84591462 join(1548344..1548420,1548736..1548999,1549048..1549083,1549171..1549271,1549598..1549738,1549849..1549885,1549930..1550014,1550159..1550236) IV 1 NT_166523.1 Title: weak similarity to sulfohydrolase II from patent WO200068395-A2 - Chondrus crispus; uncharacterized protein 1550236 84591462 An07g07230 Aspergillus niger uncharacterized protein XP_059606916.1 1548344 D 5061 CDS An07g07240 4981992 join(1550771..1551946,1551983..1552954) IV 1 NT_166523.1 Complex: F-box proteins contain a carboxy-terminal domain that interacts with substrates and a 42-48 amino-acid F-box motif which binds to the protein Skp1, the linker to the core ubiquitin ligase composed of the proteins Cdc53/Cul1, Rbx1 (also called Hrt1 and Roc1) and the E2 ubiquitin-conjugating enzyme Cdc34.; Function: F-box proteins are components of modular E3 ubiquitin protein ligases called SCFs, which function in phosphorylation-dependent ubiquitination.; Remark: the genome of S. cerevisiae contains 16 F-box proteins.; Similarity: similarity is from the central region of the predicted A. niger protein to human FBL3, which is 300 aa shorter.; Title: similarity to SCF ubiquitin ligase (E3) F-box subunit FBL3 - Homo sapiens; See PMID 10531037; See PMID 10945468; uncharacterized protein 1552954 4981992 An07g07240 Aspergillus niger uncharacterized protein XP_059606917.1 1550771 D 5061 CDS An07g07250 4981993 complement(join(1553578..1554200,1554303..1554630)) IV 1 NT_166523.1 Title: similarity to hypothetical protein SPAC12G12.02 - Schizosaccharomyces pombe; uncharacterized protein 1554630 4981993 An07g07250 Aspergillus niger uncharacterized protein XP_001391799.1 1553578 R 5061 CDS An07g07260 4981994 join(1555275..1555824,1555874..1556863,1556910..1557002,1557048..1558312) IV 1 NT_166523.1 Similarity: the predicted A. niger protein contains a WD40-repeat domain.; Title: similarity to polypeptide SEQ ID NO:2662 from patent WO200153312-A1 - Homo sapiens; uncharacterized protein 1558312 4981994 An07g07260 Aspergillus niger uncharacterized protein XP_001391800.1 1555275 D 5061 CDS An07g07270 4981995 join(1558702..1558833,1558903..1559730) IV 1 NT_166523.1 Function: S. cerevisiae TPT is implicated in the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD.; Remark: the systematic name for S. cerevisiae TPT1 is YOL102c .; Title: similarity to tRNA 2-phosphotransferase Tpt1 - Saccharomyces cerevisiae; See PMID 9148937; uncharacterized protein 1559730 4981995 An07g07270 Aspergillus niger uncharacterized protein XP_001391801.1 1558702 D 5061 CDS An07g07280 4981996 join(1560116..1560357,1560437..1560801,1560886..1560953,1561031..1561219) IV 1 NT_166523.1 Catalytic activity: Sphingomonas sp. dxnF efficiently cleaves hydroxyquinol, yielding maleylacetate,the ketoform of 3-hydroxy-cis,cis-muconate.; Function: Sphingomonas sp. dxnF is involved in the degradation pathways of dibenzo-p-dioxin and dibenzofuran.; Title: strong similarity to hydroxyquinol 1,2-dioxygenase dxnF - Sphingomonas sp.; See PMID 10348858; uncharacterized protein 1561219 4981996 An07g07280 Aspergillus niger uncharacterized protein XP_001391802.1 1560116 D 5061 CDS An07g07290 10098313 complement(join(1561474..1561835,1561888..1562424,1562572..1562701,1562739..1563548)) IV 1 NT_166523.1 Function: R. opacus pcaL is involved in the degradation of aromatic compounds.; Similarity: R. opacus pcaL is a merged enzyme consisting of a N-terminal 3-oxoadipate enol-lactone hydrolase, homologue to pcaD and a C-terminal 4-carboxymuconolactone decarboxylase homologue to pcaC.; Similarity: similarity is from the C-terminal region of the predicted A. niger protein to the N-terminal,3-oxoadipate enol-lactone hydrolase activity containing,region of, which is 200 aa shorter.; Title: similarity to 3-oxoadipate enol-lactone hydrolase part of the dual specificity protein pcaL -Rhodococcus opacus; See PMID 9495744; uncharacterized protein 1563548 10098313 An07g07290 Aspergillus niger uncharacterized protein XP_003188717.2 1561474 R 5061 CDS An07g07300 4981998 complement(join(1563819..1563821,1563934..1564053,1564133..1564502,1564573..1564757,1564832..1564889,1564962..1564972,1565036..1565104)) IV 1 NT_166523.1 Similarity: the predicted A. niger protein shows similarity to several predicted reductases/dehydrogenases.; Title: strong similarity to prostaglandin f(2alpha) synthase TbPGFS - Trypanosoma brucei; See PMID 11067881; uncharacterized protein 1565104 4981998 An07g07300 Aspergillus niger uncharacterized protein XP_001391804.3 1563819 R 5061 CDS An07g07310 4981999 join(1565920..1566003,1566056..1566544,1566624..1567277) IV 1 NT_166523.1 Function: in S. cerevisiae dom34 and D. melanogaster pelo mutants progression through the G1 phase of the cell cycle is delayed, cells enter meiosis aberrantly, nuclear envelope breakdown and spindle formation do not occur. in S. cerevisiae, the ability to form pseudohyphae is significantly diminisehd.; Function: rescue of dom34 by high copy expression of ribosomal protein S30 suggest that Dom34p functions in protein translation to promote G1 progression and differentiation.; Similarity: D. melanogaster pelo is homologue of S. cerevisiae dom34 and is able to rescue the dom34 phenotype.; Title: strong similarity to cell cycle factor pelota - Drosophila melanogaster; See PMID 9584085; See PMID 7588080; uncharacterized protein 1567277 4981999 An07g07310 Aspergillus niger uncharacterized protein XP_059606918.1 1565920 D 5061 CDS An07g07320 4982000 complement(join(1568527..1568709,1568767..1569534,1569591..1569716)) IV 1 NT_166523.1 Similarity: similarity is from the predicted A. niger protein to the central region of human INCENP, which is 600 aa longer.; Title: weak similarity to microtubule associated inner centromer protein INCENP - Homo sapiens; See PMID 11453556; uncharacterized protein 1569716 4982000 An07g07320 Aspergillus niger uncharacterized protein XP_059606919.1 1568527 R 5061 CDS An07g07330 84591463 join(1571153..1571300,1571341..1571588,1571739..1572080) IV 1 NT_166523.1 hypothetical protein 1572080 84591463 An07g07330 Aspergillus niger hypothetical protein XP_059606920.1 1571153 D 5061 CDS An07g07340 4982002 complement(join(1572444..1573064,1573126..1573412,1573475..1573574)) IV 1 NT_166523.1 Function: K. marxianus ERD2 encodes the K/H-DEL tetrapeptide receptor, required for the receptor-mediated retrieval of luminal ER proteins from the secretory pathway.; Golgi; Title: strong similarity to luminal ER-protein retention receptor ERD2 - Kluyveromyces marxianus; See PMID 2172835; See PMID 2194670; See PMID 2194671; uncharacterized protein 1573574 4982002 An07g07340 Aspergillus niger uncharacterized protein XP_001391808.1 1572444 R 5061 CDS An07g07350 84591464 join(1573682..1573912,1574215..1574299,1574339..1574422,1574539..1574597) IV 1 NT_166523.1 Title: weak similarity to protein fragment 3780 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 1574597 84591464 An07g07350 Aspergillus niger uncharacterized protein XP_059606921.1 1573682 D 5061 CDS An07g07360 84591465 complement(join(1578033..1578437,1578793..1578814,1579040..1579092,1579197..1579262)) IV 1 NT_166523.1 hypothetical protein 1579262 84591465 An07g07360 Aspergillus niger hypothetical protein XP_059606922.1 1578033 R 5061 CDS An07g07370 4982005 join(1579519..1579523,1579914..1580283,1580358..1580405,1580466..1580498,1580570..1580653,1580710..1580751) IV 1 NT_166523.1 Similarity: the predicted A. niger protein shows similarity to several Myb DNA-binding domain containing proteins.; Title: weak similarity to PC-MYB2 - Arabidopsis thaliana; See PMID 10482656; uncharacterized protein 1580751 4982005 An07g07370 Aspergillus niger uncharacterized protein XP_001391811.1 1579519 D 5061 CDS An07g07380 4982006 join(1582128..1582586,1582640..1582793,1582843..1582918,1582968..1583081,1583138..1583843,1583911..1583990,1584147..1584189) IV 1 NT_166523.1 Function: S. cerevisiae FCY2 is a purine-cytosine permease involved in the uptake of adenine, hypoxanthine and cytosine.; Title: strong similarity to cytosine/purine permease Fcy2 - Saccharomyces cerevisiae; plasma membrane; See PMID 2191181; uncharacterized protein 1584189 4982006 An07g07380 Aspergillus niger uncharacterized protein XP_059606923.1 1582128 D 5061 CDS An07g07390 4982007 complement(join(1585201..1585289,1585369..1585459,1585528..1585628,1585720..1585878,1586100..1586153,1586321..1586411)) IV 1 NT_166523.1 Remark: the exon-intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs AN06A04, AN06B04 and an_3468.; Title: strong similarity to subunit IV of cytochrome c oxidase Cox4 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 3017950; uncharacterized protein 1586411 4982007 An07g07390 Aspergillus niger uncharacterized protein XP_001391813.1 1585201 R 5061 CDS An07g07400 4982008 complement(1587336..>1588085) IV 1 NT_166523.1 Remark: ORF 5'truncated due to end of contig.; Similarity: mouse MCAP belongs to the BET subgroup of the bromodomain superfamily.; Title: weak similarity to mitotic chromosome associated MCAP - Mus musculus [truncated ORF]; uncharacterized protein 1588085 4982008 An07g07400 Aspergillus niger uncharacterized protein XP_001391814.3 1587336 R 5061 CDS An07g07410 84591466 join(<1588514..1588569,1588610..1588702,1588873..1589028,1589113..1589177,1589224..1589321,1589639..1589784,1589866..1589939,1590404..1590478,1590612..1590662,1590963..1591084,1591169..1591252) IV 1 NT_166523.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF [truncated ORF]; uncharacterized protein 1591252 84591466 An07g07410 Aspergillus niger uncharacterized protein XP_059601001.1 1588514 D 5061 CDS An07g07420 4982010 complement(join(1591717..1591722,1591774..1591933,1592331..1599388)) IV 1 NT_166523.1 Function: human Prp8 protein is a component of both U2- and U12-dependent spliceosomes.; Similarity: Prp8p is the most highly conserved large nuclear protein known.; Title: strong similarity to splicing factor PRP8 -Homo sapiens; nucleus; See PMID 9547260; See PMID 9774689; See PMID 10411133; uncharacterized protein 1599388 4982010 An07g07420 Aspergillus niger uncharacterized protein XP_001391816.3 1591717 R 5061 CDS An07g07430 4982011 join(1599923..1599946,1600016..1600029,1600222..1600345,1600555..1600746) IV 1 NT_166523.1 Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L34.b - Saccharomyces cerevisiae; cytoplasm; 60S ribosomal protein eL34 1600746 4982011 An07g07430 Aspergillus niger 60S ribosomal protein eL34 XP_001391817.1 1599923 D 5061 CDS An07g07440 84591467 join(1602681..1602740,1602953..1603084,1603161..1603262,1603346..1603376,1603583..1603641,1603803..1603923,1604087..1604297,1604372..1604549,1604741..1604955,1605040..1605088,1605195..1605309,1605407..1605574,1606099..1606190,1606310..1606372,1606414..1606467,1606602..1606739,1606896..1606979) IV 1 NT_166523.1 hypothetical protein 1606979 84591467 An07g07440 Aspergillus niger hypothetical protein XP_059601002.1 1602681 D 5061 CDS An07g07450 4982013 complement(join(1607246..1607848,1607927..1608718)) IV 1 NT_166523.1 Similarity: shows similarity to forkhead containing transcription factors, but similarity is only in the forkhead domain.; Title: similarity to fork head protein Fkh1 -Saccharomyces cerevisiae; See PMID 12183363; uncharacterized protein 1608718 4982013 An07g07450 Aspergillus niger uncharacterized protein XP_059601003.1 1607246 R 5061 CDS An07g07460 4982014 complement(join(1610481..1610498,1610559..1610591,1610645..1611271,1611323..1611790,1611854..1612357)) IV 1 NT_166523.1 Function: cactin of D. melanogaster is a conserved protein that interacts with the Drosophila IkappaB protein cactus and modulates its function.; Similarity: shows strong similarity to 500 C-terminal aminoacids of D. melano9gaster cactin.; Title: similarity to Rel pathway controlling protein cactin - Drosophila melanogaster; See PMID 10842059; uncharacterized protein 1612357 4982014 An07g07460 Aspergillus niger uncharacterized protein XP_059601004.1 1610481 R 5061 CDS An07g07470 4982015 join(1613045..1613593,1613647..1614456) IV 1 NT_166523.1 Title: weak similarity to nucleolar phosphoprotein p130 - Homo sapiens; uncharacterized protein 1614456 4982015 An07g07470 Aspergillus niger uncharacterized protein XP_001391821.3 1613045 D 5061 CDS An07g07480 4982016 complement(join(1614947..1614985,1615189..1618942,1619239..1619468)) IV 1 NT_166523.1 Title: similarity to polypeptide SEQ ID NO:4314 from patent WO200171042-A2 - Drosophila melanogaster; uncharacterized protein 1619468 4982016 An07g07480 Aspergillus niger uncharacterized protein XP_001391822.3 1614947 R 5061 CDS An07g07490 84591468 complement(join(1621170..1621412,1621460..1621556,1621645..1621731,1621830..1621899,1621965..1622028)) IV 1 NT_166523.1 Title: similarity to EST an_3112 - Aspergillus niger; uncharacterized protein 1622028 84591468 An07g07490 Aspergillus niger uncharacterized protein XP_059601005.1 1621170 R 5061 CDS An07g07500 4982018 join(1623889..1624245,1624335..1625443,1625502..1626795) IV 1 NT_166523.1 Function: HMT1 of Schizosaccharomyces pombe confers resistance to cadmium.; Similarity: shows strong similarity to several known and hypothetical ABC-transporter proteins with different specificities of different species.; Title: strong similarity to ABC-type vacuolar membrane protein hmt1p - Schizosaccharomyces pombe; See PMID 7876244; uncharacterized protein 1626795 4982018 An07g07500 Aspergillus niger uncharacterized protein XP_001391824.1 1623889 D 5061 CDS An07g07510 4982019 join(1627502..1628015,1628122..1628318) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein EAA60859.1 - Aspergillus nidulans; uncharacterized protein 1628318 4982019 An07g07510 Aspergillus niger uncharacterized protein XP_001391825.1 1627502 D 5061 CDS An07g07520 4982020 join(1628808..1630299,1630356..1630651) IV 1 NT_166523.1 Catalytic activity: alkaline phosphates catalyzes the conversion of an orthophosphoric monoester + H2O = an alcohol + orthophosphate.; Function: Pho8p of S. cerevisiae dephosphorylates phosphopeptides.; Function: Pho8p of S. cerevisiae is a type II integral membrane protein with short N-terminal cytoplasmic tail.; Function: Pho8p of S. cerevisiae is a vacuolar repressible alkaline phosphatase.; Function: Pho8p of S. cerevisiae is anchored in the membrane by an N-terminal transmembrane domain which appear to be an uncleaved signal sequence.; Title: strong similarity to vacuolar alkaline phosphatase Pho8 - Saccharomyces cerevisiae; See PMID 8499492; uncharacterized protein 1630651 4982020 An07g07520 Aspergillus niger uncharacterized protein XP_001391826.1 1628808 D 5061 CDS An07g07525 84591469 complement(join(1630859..1630969,1631015..1631104)) IV 1 NT_166523.1 hypothetical protein 1631104 84591469 An07g07525 Aspergillus niger hypothetical protein XP_059601006.1 1630859 R 5061 CDS An07g07530 4982022 complement(join(1631962..1632674,1632736..1633173,1633240..1633363)) IV 1 NT_166523.1 Function: UTR2 (alias CRH2) of S. cerevsiae is involved in cell wall organization at different stages of the yeast life cycle.; Title: strong similarity to cell wall protein Utr2 -Saccharomyces cerevisiae; See PMID 10757808; uncharacterized protein 1633363 4982022 An07g07530 Aspergillus niger uncharacterized protein XP_059601007.1 1631962 R 5061 CDS An07g07550 4982024 join(1638801..1638869,1638922..1639044,1639107..1639884,1639941..1640137) IV 1 NT_166523.1 hypothetical protein 1640137 4982024 An07g07550 Aspergillus niger hypothetical protein XP_059601008.1 1638801 D 5061 CDS An07g07560 4982025 complement(join(1640637..1640670,1640731..1641049,1641153..1641339)) IV 1 NT_166523.1 Catalytic activity: peptide methionine sulfoxide reductase catalyzes the conversion of protein methionine + oxidized thioredoxin = protein L-methionine S-oxide + reduced thioredoxin.; Function: one of the known posttranslational modification of proteins is the oxidation of methionine residues to methionine sulfoxide; this oxidation can occur since a variety of reactive molecules that are by-products of aerobic metabolism such as the superoxide anion,hydrogen peroxide, hydroxyl radical, and hypochlorite ion are capable of causing this oxidation.; Function: peptide methionine sulfoxide reductase (EC 1. 8. 4. 6), has been detected in virtually all organisms examined, catalyzes the reduction of Met(O) residues in proteins to methionine; Function: peptide methionine sulfoxide reductase could have an important function in providing cells with a defense against oxidative stress.; Remark: the systematic genename of MXR1 of S. cerevsiae is YER042W.; Title: strong similarity to peptide methionine sulfoxide reductase Mxr1 - Saccharomyces cerevisiae; See PMID 10473395; uncharacterized protein 1641339 4982025 An07g07560 Aspergillus niger uncharacterized protein XP_001391831.3 1640637 R 5061 CDS An07g07570 4982026 complement(join(1642128..1644969,1645028..1645218)) IV 1 NT_166523.1 Function: Kip3 of S. cerevisiae operates within the nucleus to assemble and elongate the bipolar spindle.; Function: in S. cerevisiae kinesin-related proteins are involved within the nucleus to assemble and elongate the bipolar spindle and on the cytoplasmic microtubules to effect spindle and nuclear positioning within the cell.; Localization: Kip3 of S. cerevisiae is located on the astral and central microtubules in the cytoplasm and is also present in the nucleus.; Remark: Kip3 of S. cerevisiae has a systematic name of YGL216W.; Similarity: shows similarity to the N-terminal,kinesin motor domain containing half of several kinesin-related proteins of different organisms.; Title: similarity to kinesin-related protein Kip3 -Saccharomyces cerevisiae; See PMID 9281581; uncharacterized protein 1645218 4982026 An07g07570 Aspergillus niger uncharacterized protein XP_001391832.1 1642128 R 5061 CDS An07g07580 4982027 complement(1646192..1646692) IV 1 NT_166523.1 hypothetical protein 1646692 4982027 An07g07580 Aspergillus niger hypothetical protein XP_001391833.3 1646192 R 5061 CDS An07g07590 4982028 join(1647013..1647466,1647554..1647711) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein EAA60854.1 - Aspergillus nidulans; uncharacterized protein 1647711 4982028 An07g07590 Aspergillus niger uncharacterized protein XP_059601009.1 1647013 D 5061 CDS An07g07600 84591470 join(1649553..1649657,1649745..1650036,1650165..>1650986) IV 1 NT_166523.1 Protein sequence is in conflict with the conceptual translation; Function: proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; such a domain is known to exist in the following proteins: prokaryotic catabolite gene activator protein (CAP), cAMP- and cGMP-dependent protein kinases (cAPK and cGPK), vertebrate cyclic nucleotide-gated ion-channels.; Remark: a possible sequencing error occured at position 70830 leading to a stop, 1 base has been removed.; Similarity: shows similarity to several cyclic nucleotide-gated channel proteins of different organisms,but the similarity is only restricted to the cyclic nucleotide-binding domain.; Title: similarity to protein SEQ ID NO:7729 from patent WO200253728-A2 - Candida albicans [putative sequencing error]; putative sequencing error; uncharacterized protein 1650986 84591470 An07g07600 Aspergillus niger uncharacterized protein XP_059601010.1 1649553 D 5061 CDS An07g07610 4982030 join(1651442..1652572,1652622..1652966) IV 1 NT_166523.1 Remark: shows some similarity to several other F-box containing proteins of different organisms.; Title: similarity to leucine-rich repeats containing F-box protein FBL6 - Homo sapiens; See PMID 10531035; See PMID 10945468; uncharacterized protein 1652966 4982030 An07g07610 Aspergillus niger uncharacterized protein XP_001391836.3 1651442 D 5061 CDS An07g07620 84591471 complement(join(1653400..1653556,1653684..1654478,1654681..1655000)) IV 1 NT_166523.1 Title: weak similarity to hypothetical protein CG3918 - Drosophila melanogaster; uncharacterized protein 1655000 84591471 An07g07620 Aspergillus niger uncharacterized protein XP_059601011.1 1653400 R 5061 CDS An07g07630 4982032 join(1655801..1655873,1655949..1656103,1656331..1656455,1656510..1657794,1657867..1658568) IV 1 NT_166523.1 Function: Avenacinase of G. graminis detoxifies the triterpenoid oat root saponin avenacin A-1, and is essential for pathogenicity of G. graminis var. avenae to oats.; Similarity: shows also strong similarity to several known and hypothetical beta-glucosidases of different organisms.; Title: strong similarity to avenacinase -Gaeumannomyces graminis; uncharacterized protein 1658568 4982032 An07g07630 Aspergillus niger uncharacterized protein XP_059601012.1 1655801 D 5061 CDS An07g07640 84591472 join(1661064..1661892,1661948..1661985,1662048..1662278,1662344..1663699) IV 1 NT_166523.1 Remark: blast matches are not significant.; Title: weak similarity to protein sequence #58 from patent WO200224865-A2 - Unclassified organism; uncharacterized protein 1663699 84591472 An07g07640 Aspergillus niger uncharacterized protein XP_059601013.1 1661064 D 5061 CDS An07g07650 4982034 complement(join(1664140..1664264,1664521..1666963)) IV 1 NT_166523.1 Remark: blast matches are nopt significant.; hypothetical protein 1666963 4982034 An07g07650 Aspergillus niger hypothetical protein XP_001391840.3 1664140 R 5061 CDS An07g07660 4982035 complement(join(1667614..1667928,1667984..1668106,1668158..1668319)) IV 1 NT_166523.1 Title: similarity to hypothetical protein SPCC24B10.12 - Schizosaccharomyces pombe; uncharacterized protein 1668319 4982035 An07g07660 Aspergillus niger uncharacterized protein XP_001391841.1 1667614 R 5061 CDS An07g07670 4982036 join(1668669..1669186,1669251..1669734) IV 1 NT_166523.1 Title: similarity to hypothetical protein CG1287 -Drosophila melanogaster; uncharacterized protein 1669734 4982036 An07g07670 Aspergillus niger uncharacterized protein XP_001391842.1 1668669 D 5061 CDS An07g07680 4982037 complement(join(1670993..1671700,1671828..1671830)) IV 1 NT_166523.1 hypothetical protein 1671830 4982037 An07g07680 Aspergillus niger hypothetical protein XP_059601014.1 1670993 R 5061 CDS An07g07690 4982038 join(1673196..1673447,1673578..1673808) IV 1 NT_166523.1 Function: Y14 of X. laevis associates preferentially with mRNAs produced by splicing but not with pre-mRNAs,introns, or mRNAs produced from intronless cDNAs.; Function: Y14 of X. laevis associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs.; Function: Y14 of X. laevis is reported to define novel intermediates in the pathway of gene expression,postsplicing nuclear preexport mRNPs, and newly exported cytoplasmic mRNPs, whose composition is established by splicing.; Localization: Y14 of X. laevis is a predominantly nuclear nucleocytoplasmic shuttling protein.; Title: strong similarity to RNA-binding protein Y14 - Xenopus laevis; See PMID 11030346; uncharacterized protein 1673808 4982038 An07g07690 Aspergillus niger uncharacterized protein XP_001391844.1 1673196 D 5061 CDS An07g07700 4982039 join(1675152..1675155,1675198..1677011) IV 1 NT_166523.1 Title: similarity to hypothetical glycosyl hydrolase BAC68337.1 - Streptomyces avermitilis; uncharacterized protein 1677011 4982039 An07g07700 Aspergillus niger uncharacterized protein XP_059601015.1 1675152 D 5061 CDS An07g07710 84591473 join(1678958..1679072,1679155..1679251,1679371..1679485,1679548..1679588,1679632..1679778,1679883..1680036,1680120..1680314) IV 1 NT_166523.1 Title: weak similarity to signal peptidase I sip -Streptomyces lividans; uncharacterized protein 1680314 84591473 An07g07710 Aspergillus niger uncharacterized protein XP_059601016.1 1678958 D 5061 CDS An07g07720 84591474 join(1681085..1681166,1681231..1681518,1681742..1681833,1681921..1682276,1682441..1682611,1682828..1682878,1682980..1683169) IV 1 NT_166523.1 hypothetical protein 1683169 84591474 An07g07720 Aspergillus niger hypothetical protein XP_059601017.1 1681085 D 5061 CDS An07g07730 84591475 complement(join(1684157..1684159,1684308..1684388,1684468..1684530)) IV 1 NT_166523.1 hypothetical protein 1684530 84591475 An07g07730 Aspergillus niger hypothetical protein XP_059601018.1 1684157 R 5061 CDS An07g07740 4982043 join(1685707..1686026,1686133..1686319) IV 1 NT_166523.1 Title: weak similarity to hypothetical protein HRIHFB2072 - Homo sapiens; uncharacterized protein 1686319 4982043 An07g07740 Aspergillus niger uncharacterized protein XP_001391849.1 1685707 D 5061 CDS An07g07750 84591476 complement(join(1688342..1688369,1688472..1688476,1688621..1688659,1688735..1688797,1688844..1688861,1688967..1689068)) IV 1 NT_166523.1 hypothetical protein 1689068 84591476 An07g07750 Aspergillus niger hypothetical protein XP_059601019.1 1688342 R 5061 CDS An07g07760 4982045 complement(join(1689940..1690041,1690094..1690164,1690220..1690461,1690539..1690845,1690930..1690990)) IV 1 NT_166523.1 Complex: the 14-3-3 proteins Rad24 and Rad25 physically interact with Chk1 in fission yeast.; Function: rad24 from S. pombe is required for the DNA damage checkpoint which ensures that DNA damage is repaired before mitosis is attempted. S. pombe rad24 null mutants enter mitosis prematurely.; Remark: apart from checkpoint control, the 14-3-3 family of proteins plays a key regulatory role in signal transduction, apoptotic, and nutrient-sensing pathways.; Similarity: the predicted A. niger protein shows strong similarity to DNA damage checkpoint protein rad24 from S. pombe, which belongs to the 14-3-3 protein family.; Title: strong similarity to DNA damage checkpoint protein rad24p - Schizosaccharomyces pombe; See PMID 10090724; See PMID 11152955; See PMID 8036497; uncharacterized protein 1690990 4982045 An07g07760 Aspergillus niger uncharacterized protein XP_001391851.1 1689940 R 5061 CDS An07g07770 84591477 join(1691261..1691701,1691848..1691899,1691971..1692031,1692262..1692358) IV 1 NT_166523.1 Title: weak similarity to hypothetical protein P0034C11.5 - Oryza sativa; uncharacterized protein 1692358 84591477 An07g07770 Aspergillus niger uncharacterized protein XP_059601020.1 1691261 D 5061 CDS An07g07780 4982047 join(1694083..1694219,1694341..1694406,1694496..1694561,1694635..1694674) IV 1 NT_166523.1 Function: Inh1p of S. cerevisiae forms a one-to-one complex with ATPase to inhibit enzyme activity completely.; Remark: the systematic genename of INH1 of S. cerevisiae is YDL181w.; Title: similarity to mitochondrial H+-transporting ATP synthase inhibitor precursor Inh1 - Saccharomyces cerevisiae; See PMID 10838056; See PMID 2138617; uncharacterized protein 1694674 4982047 An07g07780 Aspergillus niger uncharacterized protein XP_001391853.1 1694083 D 5061 CDS An07g07790 4982048 complement(join(1695189..1695395,1695455..1695578,1695645..1696905,1696960..1697404)) IV 1 NT_166523.1 Function: Nsp1 is located at the nuclear periphery in yeast and is essential for cell growth.; Function: the nucleoporin Nsp1 from S. cerevisiae is involved in the process of nuclear and/or cell division.; Localization: Nsp1p resides in three distinct subcomplexes of the nuclear pore complex which are located at the entry and exit of the central gated channel and at the terminal ring of the nuclear basket.; Remark: nucleoporins may be involved in both binding and translocation of the proteins during nucleocytoplasmic transport.; Title: similarity to nucleoporin Nsp1 -Saccharomyces cerevisiae; See PMID 9813081; See PMID 2112428; See PMID 3072197; uncharacterized protein 1697404 4982048 An07g07790 Aspergillus niger uncharacterized protein XP_059601021.1 1695189 R 5061 CDS An07g07800 4982049 join(1697956..1698046,1698107..1698694,1698753..1698982,1699039..1699757,1699965..1700025,1700237..1700290,1700366..1700407) IV 1 NT_166523.1 Title: similarity to hypothetical protein SPAC8E11.05c - Schizosaccharomyces pombe; uncharacterized protein 1700407 4982049 An07g07800 Aspergillus niger uncharacterized protein XP_001391855.3 1697956 D 5061 CDS An07g07810 10098314 complement(join(1700785..1704486,1704735..1704850,1705022..1705175)) IV 1 NT_166523.1 Title: weak similarity to protein inhibitor of activated STAT protein PIASX - Homo sapiens; uncharacterized protein 1705175 10098314 An07g07810 Aspergillus niger uncharacterized protein XP_003188733.2 1700785 R 5061 CDS An07g07820 4982051 join(1707083..1707140,1707236..1707379,1707454..1708223,1708287..1709691,1709773..1709867,1709969..1710028) IV 1 NT_166523.1 Function: Pob1p of S. pombe exhibits subcellular localization close to actin patches, is essential for cell elongation and separation.; Similarity: shows also similarity to Boi2p of S. cerevisiae.; Title: similarity to cell elongation and separation protein ob1p - Schizosaccharomyces pombe; See PMID 10436025; uncharacterized protein 1710028 4982051 An07g07820 Aspergillus niger uncharacterized protein XP_059601022.1 1707083 D 5061 CDS An07g07830 4982052 1710663..1712357 IV 1 NT_166523.1 Title: similarity to hypothetical protein YIL039w -Saccharomyces cerevisiae; uncharacterized protein 1712357 4982052 An07g07830 Aspergillus niger uncharacterized protein XP_001391858.1 1710663 D 5061 CDS An07g07840 4982053 complement(join(1712619..1712651,1712723..1712800,1712900..1713146,1713392..1713442,1713752..1713765)) IV 1 NT_166523.1 Remark: L23 of S. cerevisiae is also called RPL17b,YBL0713, YBL087c, YER117w, or YL17a.; Similarity: most homologs are about 50 amino acids shorter at N-terminus.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L23 - Saccharomyces cerevisiae; cytoplasm; 60S ribosomal protein uL14 1713765 4982053 An07g07840 Aspergillus niger 60S ribosomal protein uL14 XP_001391859.1 1712619 R 5061 CDS An07g07850 4982054 complement(join(1714255..1715283,1715332..1715873,1715921..1716221,1716306..1716500)) IV 1 NT_166523.1 Function: histone deacetylases are responsible for the deacetylation of lysine residues on the N-terminal part of the core histones.; Function: histone deacetylation plays an important role in transcriptional regulation, cell cycle progression and developmental events.; Function: the acetylation and deacetylation of histones is involved in the regulation of transcription and replication of DNA.; Title: strong similarity to histone deacetylase rpd3A - Aspergillus nidulans; See PMID 9780836; See PMID 11004483; uncharacterized protein 1716500 4982054 An07g07850 Aspergillus niger uncharacterized protein XP_001391860.1 1714255 R 5061 CDS An07g07860 4982055 join(1717101..1717163,1717244..1717497,1717556..1718091,1718148..1718290) IV 1 NT_166523.1 Complex: the 26S proteasome is made up of two multisubunit complexes, the 20S catalytic core and the 19S regulatory complex.; Function: Pad1 has been isolated as a subunit of the 26 S proteasome in fission yeast.; Remark: the 26S proteasome is the multiprotein complex that degrades proteins that have been marked for destruction by the ubiquitin pathway.; Similarity: shows strong similarity to S. cerevisiae 19S proteasome regulatory particle Rpn11p.; Title: strong similarity to 26S proteasomal subunit ad1p - Schizosaccharomyces pombe; See PMID 9727008; See PMID 10582238; uncharacterized protein 1718290 4982055 An07g07860 Aspergillus niger uncharacterized protein XP_001391861.1 1717101 D 5061 CDS An07g07870 4982056 complement(1718630..1719580) IV 1 NT_166523.1 Similarity: C-terminus shows similarity to C-terminal part of restless-like transposase of N. haematococca.; Title: weak similarity to hypothetical restless-like transposase - Nectria haematococca; uncharacterized protein 1719580 4982056 An07g07870 Aspergillus niger uncharacterized protein XP_001391862.1 1718630 R 5061 CDS An07g07880 4982057 join(1720312..1720557,1720617..1721336,1721392..1721979) IV 1 NT_166523.1 Remark: similarity to human ORFX ORF2689 polypeptide sequence SEQ ID NO:5378 patent WO200058473-A2.; Title: similarity to ORFX ORF2689 polypeptide sequence SEQ ID NO:5378 from patent WO200058473-A2 - Homo sapiens; uncharacterized protein 1721979 4982057 An07g07880 Aspergillus niger uncharacterized protein XP_001391863.1 1720312 D 5061 CDS An07g07890 84591478 complement(join(1722426..1722573,1722622..1722692)) IV 1 NT_166523.1 hypothetical protein 1722692 84591478 An07g07890 Aspergillus niger hypothetical protein XP_059601023.1 1722426 R 5061 CDS An07g07900 84591479 complement(join(1723450..1723504,1723598..1723737,1723826..1723843)) IV 1 NT_166523.1 hypothetical protein 1723843 84591479 An07g07900 Aspergillus niger hypothetical protein XP_059601024.1 1723450 R 5061 CDS An07g07910 4982060 join(1723909..1724093,1724207..1726988) IV 1 NT_166523.1 Remark: a complex of the nuclear matrix proteins SRm160 and SRm300 functions as a coactivator of pre-mRNA splicing. The SRm160/300 complex associates with splicing complexes and promotes splicing through interactions with SR family proteins.; Title: similarity to Ser/Arg-related nuclear matrix protein SRM160 - Homo sapiens; See PMID 9531537; uncharacterized protein 1726988 4982060 An07g07910 Aspergillus niger uncharacterized protein XP_001391866.1 1723909 D 5061 CDS An07g07920 84591480 join(1727719..1728235,1728298..1728520,1728589..1728733,1728785..1729129) IV 1 NT_166523.1 hypothetical protein 1729129 84591480 An07g07920 Aspergillus niger hypothetical protein XP_059601025.1 1727719 D 5061 CDS An07g07930 4982062 join(1730443..1730640,1730726..1731165,1731216..1731653,1731710..1731978,1732035..1732568,1732626..1732939) IV 1 NT_166523.1 Remark: LEU3 gene, whose product is involved in the specific regulation of the leucine and possibly the isoleucine-valine pathways, is itself under general amino acid control.; Remark: LEU3 is necessary for expression of wild-type levels of LEU1- and LEU2-specific RNAs and,further, that the levels of LEU4-specific transcripts are also affected by LEU3.; Similarity: belongs to the unassigned GAL4-type zinc cluster proteins.; Title: strong similarity to leucine-specific regulatory protein Leu3 - Saccharomyces cerevisiae; See PMID 2823102; See PMID 3299266; uncharacterized protein 1732939 4982062 An07g07930 Aspergillus niger uncharacterized protein XP_001391868.1 1730443 D 5061 CDS An07g07940 4982063 complement(1734434..1737070) IV 1 NT_166523.1 Title: similarity to hypothetical protein B13A5.70 -Neurospora crassa; uncharacterized protein 1737070 4982063 An07g07940 Aspergillus niger uncharacterized protein XP_059601026.1 1734434 R 5061 CDS An07g07950 84591481 join(1737077..1737162,1737290..1737353,1737447..1737572,1737647..1738033) IV 1 NT_166523.1 hypothetical protein 1738033 84591481 An07g07950 Aspergillus niger hypothetical protein XP_059601027.1 1737077 D 5061 CDS An07g07960 84591482 complement(join(1738110..1738254,1738331..1738395,1738475..1738597,1738899..1738985)) IV 1 NT_166523.1 Remark: putative regulator element in A. terreus for lovastatin or monacolin J production.; Remark: weak similarity to A. terreus ORF5 protein patent WO200037629-A2.; Title: weak similarity to ORF5 protein from patent WO200037629-A2 - Aspergillus terreus; uncharacterized protein 1738985 84591482 An07g07960 Aspergillus niger uncharacterized protein XP_059601028.1 1738110 R 5061 CDS An07g07970 4982066 join(<1740268..1740486,1740869..1741113,1741219..1742386) IV 1 NT_166523.1 Catalytic activity: ATP + protein = ADP + O-phosphoprotein.; Remark: N-terminal truncated ORF due to end of contig.; Remark: RCK2 encodes a 65-kDa protein with similarity to second messenger-regulated kinase. Disruption of these gene demonstrates that it is non-essential. s; Similarity: belongs to the unassigned Ser/Thr or Tyr-specific protein kinases.; Title: strong similarity to Ca/calmodulin-dependent ser/thr protein kinase Rck2 - Saccharomyces cerevisiae [truncated ORF]; See PMID 8112585; uncharacterized protein 1742386 4982066 An07g07970 Aspergillus niger uncharacterized protein XP_001391872.3 1740268 D 5061 CDS An07g07980 4982067 complement(join(1744191..1744756,1744817..1745250,1745304..1745453,1745507..1745724,1745793..1745805,1745863..1745962,1746093..1746369)) IV 1 NT_166523.1 Remark: SVOP and SV2 are more distantly related to eukaryotic and bacterial phosphate, sugar, and organic acid transporters. SVOP is expressed at detectable levels only in brain and endocrine cells where it is primarily localized to synaptic vesicles and microvesicles.; Remark: strong similarity to EST an_3633 from Aspergillus niger.; Similarity: belongs to the sugar transporter family.; Title: strong similarity to SV2 related protein SVOP - Rattus norvegicus; See PMID 9801366; uncharacterized protein 1746369 4982067 An07g07980 Aspergillus niger uncharacterized protein XP_001391873.1 1744191 R 5061 CDS An07g07990 84591483 join(1746428..1746563,1746688..1746798,1746920..1747103,1747145..1747220) IV 1 NT_166523.1 hypothetical protein 1747220 84591483 An07g07990 Aspergillus niger hypothetical protein XP_059601029.1 1746428 D 5061 CDS An07g08000 84591484 complement(join(1747573..1747633,1747715..1747817,1748051..1748257,1748461..1748656,1748842..1748923,1749016..1749197,1749299..1749443,1749528..1749612,1749784..1749895)) IV 1 NT_166523.1 hypothetical protein 1749895 84591484 An07g08000 Aspergillus niger hypothetical protein XP_059601030.1 1747573 R 5061 CDS An07g08010 4982070 join(1750531..1750568,1750628..1750793,1750879..1752006) IV 1 NT_166523.1 Remark: nudF E. nidulans is required for nuclear migration during vegetative growth as well as development.; Title: strong similarity to nuclear migration factor nudF - Aspergillus nidulans; See PMID 7612965; uncharacterized protein 1752006 4982070 An07g08010 Aspergillus niger uncharacterized protein XP_001391876.1 1750531 D 5061 CDS An07g08020 84591485 complement(join(1752043..1752211,1752435..1752511,1752597..1752776)) IV 1 NT_166523.1 hypothetical protein 1752776 84591485 An07g08020 Aspergillus niger hypothetical protein XP_059601031.1 1752043 R 5061 CDS An07g08030 4982072 complement(join(1753360..1754246,1754307..1754533,1754604..1754886,1754940..1755138)) IV 1 NT_166523.1 Catalytic activity: release of a C-terminal amino acid with a broad specificity. Preferential release of a C-terminal arginine or lysine residue.; Function: removes any amino acid from the c-terminus of a long peptide. digests preferentially peptides containing a positively charged residue in p1' position, as well as arginine, lysine or phenylalanine in p1 position of ester substrate. optimal ph is 4; enzyme is unstable above pH 8. catalyze also peptide synthesis.; Gene-ID: pepF; Mapping: pepF from A. niger is mapped to chromosome IV; see PUBMED 9309173.; Remark: pepF is transcribed as a single 1. 8-kb mRNA, which is regulated by nitrogen and carbon repression,specific induction and the pH of the culture medium.; Remark: the enzyme had a pH optima of about 4 and was unstable above pH 7. It is specific for Arg, Lys, and Phe in P1.; Similarity: belongs to the peptidase family s10; also known as the serine carboxypeptidase family.; See PMID 7828908; serine carboxypeptidase pepF-Aspergillus niger 1755138 pepF 4982072 pepF Aspergillus niger serine carboxypeptidase pepF-Aspergillus niger XP_001391878.1 1753360 R 5061 CDS An07g08040 84591486 complement(join(1755248..1755546,1755641..1755689)) IV 1 NT_166523.1 Remark: the complete pepF is ORF 40CG.; Title: strong similarity to EST serine carboxypeptidase pepF - Aspergillus niger; uncharacterized protein 1755689 84591486 An07g08040 Aspergillus niger uncharacterized protein XP_059601032.1 1755248 R 5061 CDS An07g08050 84591487 complement(join(1756197..1756364,1756404..1756413,1756479..1756570,1756613..1756645)) IV 1 NT_166523.1 Remark: the complete pepF is ORF 40CG.; Title: strong similarity to EST serine carboxypeptidase pepF - Aspergillus niger; uncharacterized protein 1756645 84591487 An07g08050 Aspergillus niger uncharacterized protein XP_059601033.1 1756197 R 5061 CDS An07g08060 84591488 join(1757566..1757704,1757738..>1758222) IV 1 NT_166523.1 Remark: C-terminal truncated ORF due to end of contig.; Title: similarity to hypothetical membrane protein YOL119c - Saccharomyces cerevisiae [truncated ORF]; uncharacterized protein 1758222 84591488 An07g08060 Aspergillus niger uncharacterized protein XP_059601034.1 1757566 D 5061 CDS An07g08070 84591489 1758645..1759604 IV 1 NT_166523.1 hypothetical protein 1759604 84591489 An07g08070 Aspergillus niger hypothetical protein XP_059601035.1 1758645 D 5061 CDS An07g08080 84591490 complement(1760281..1760670) IV 1 NT_166523.1 Remark: A. niger EST an_1127 can be found in EMBLEST (AC:BE760196. 1).; Similarity: the ORF shows weak similarity to mitochondrial NADH dehydrogenases (EC 1. 6. 5. 3), but the ORF is 321 amino acids shorter.; Title: strong similarity to EST an_1127 -Aspergillus niger; uncharacterized protein 1760670 84591490 An07g08080 Aspergillus niger uncharacterized protein XP_059601036.1 1760281 R 5061 CDS An07g08090 84591491 join(1760835..1760936,1761020..1761094) IV 1 NT_166523.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght of only 58 amino acids.; Title: questionable ORF; uncharacterized protein 1761094 84591491 An07g08090 Aspergillus niger uncharacterized protein XP_059601037.1 1760835 D 5061 CDS An07g08100 4982079 complement(join(1761169..1764723,1764802..1764832,1764917..1765251)) IV 1 NT_166523.1 Function: nik-1 of N. crassa is a two-component autophosphorylating histidine kinase that is involved in hyphal development of the fungi.; Phenotype: deletion of the nik-1+ gene in N. crassa results in an organism that displays aberrant hyphal structure, which is enhanced under conditions of high osmostress.; Remark: nik-1 of N. crassa is identical to a predicted os-1+ protein.; Similarity: the ORF shows similarity to several osmosensing histidine kinases from different species.; Title: strong similarity to histidine kinase nik-1 -Neurospora crassa; See PMID 9142740; uncharacterized protein 1765251 4982079 An07g08100 Aspergillus niger uncharacterized protein XP_059601038.1 1761169 R 5061 CDS An07g08110 84591492 join(1765329..1765381,1765470..1765589,1765880..1766039,1766134..1766172,1766234..1766333,1766444..1766514,1766568..1766642,1766779..1766934) IV 1 NT_166523.1 Function: the sequence of the predicted ORF shows similarity to a 8-residue repeats containing M. musculus sequence, which is believed to be conserved in eukaryotic genomes.; Title: similarity to hypothetical protein T2 - Mus musculus; See PMID 1458435; uncharacterized protein 1766934 84591492 An07g08110 Aspergillus niger uncharacterized protein XP_059601039.1 1765329 D 5061 CDS An07g08120 84591493 complement(join(1767520..1767589,1767701..1767766,1768256..1768263,1768353..1768571,1768772..1768900,1768979..1769010,1769054..1769143,1769458..1769729,1769858..1770018)) IV 1 NT_166523.1 hypothetical protein 1770018 84591493 An07g08120 Aspergillus niger hypothetical protein XP_059601040.1 1767520 R 5061 CDS An07g08130 84591494 join(1770343..1770373,1770447..1770518,1770602..1770746,1770795..1770849) IV 1 NT_166523.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght of only 100 amino acids.; Title: questionable ORF; uncharacterized protein 1770849 84591494 An07g08130 Aspergillus niger uncharacterized protein XP_059601041.1 1770343 D 5061 CDS An07g08140 4982083 1771579..>1772562 IV 1 NT_166523.1 Catalytic activity: the phenylalanyl-tRNA synthetase fre2 of S. cerevisiae converts ATP + L-phenylalanine + tRNA(Phe) <=> AMP + diphosphate + L-phenylalanyl-tRNA(Phe).; Complex: the cytoplasmic phenylalanyl-tRNA synthetase from baker's yeast is a tetramer of the alpha 2 beta 2 type, of which fre2 is one subunit.; Remark: fre2 of S. cerevisiae is also called YFL022C.; Remark: the ORF is C-terminally truncated due to contig border.; Title: strong similarity to cytosolic phenylalanine--tRNA ligase beta subunit Frs2 -Saccharomyces cerevisiae [truncated ORF]; cytoplasm; See PMID 2644133; uncharacterized protein 1772562 4982083 An07g08140 Aspergillus niger uncharacterized protein XP_001391889.3 1771579 D 5061 CDS An07g08160 4982085 complement(join(1773269..1774242,1774346..1774457)) IV 1 NT_166523.1 Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_0868 and an_0871 .; Title: weak similarity to RP2 - Mus musculus; See PMID 3755524; uncharacterized protein 1774457 4982085 An07g08160 Aspergillus niger uncharacterized protein XP_059601042.1 1773269 R 5061 CDS An07g08170 4982086 complement(join(1775104..1776245,1776456..1776764,1776833..1776983)) IV 1 NT_166523.1 Catalytic activity: Inosine-5'-monophosphate dehydrogenases convert Inosine 5'-phosphate + NAD(+) + H(2)O to xanthosine 5'-phosphate + NADH.; Function: C. albicans IMH3 is the key enzyme in the de novo biosynthesis of GMP.; Title: strong similarity to IMP dehydrogenase IMH3 -Candida albicans; See PMID 9079920; uncharacterized protein 1776983 4982086 An07g08170 Aspergillus niger uncharacterized protein XP_001391892.3 1775104 R 5061 CDS An07g08180 84591495 complement(join(1777425..1777612,1777709..1777762,1777858..1778200)) IV 1 NT_166523.1 hypothetical protein 1778200 84591495 An07g08180 Aspergillus niger hypothetical protein XP_059601043.1 1777425 R 5061 CDS An07g08190 4982088 join(1778763..1778833,1778931..1779050,1779101..1779301,1779360..1779524,1779581..1779724,1779782..1779936,1779976..1779995) IV 1 NT_166523.1 Function: barley glucose dehydrogenase is involved in carbohydrate metabolism during embryogenesis.; Title: strong similarity to glucose dehydrogenase -Hordeum vulgare; See PMID 7764620; uncharacterized protein 1779995 4982088 An07g08190 Aspergillus niger uncharacterized protein XP_059601044.1 1778763 D 5061 CDS An07g08200 4982089 complement(join(1780248..1780343,1780441..1780725)) IV 1 NT_166523.1 Title: weak similarity to secreted form of protein F - Human respiratory syncytial virus; uncharacterized protein 1780725 4982089 An07g08200 Aspergillus niger uncharacterized protein XP_059601045.1 1780248 R 5061 CDS An07g08210 4982090 join(1781991..1783641,1783786..1786227,1786280..1786558,1786619..1787508) IV 1 NT_166523.1 Complex: human IQGAP1 binds to beta-catenin, actin,members of the Rho family, E-cadherin and calmodulin.; Function: binding of human IQGAP1 maintained Cdc42 in the active GTP-bound state.; Function: human IQGAP1 induces the dissociation of alpha-catenin from the cadherin-catenins complex leading to disruption of cell-cell adhesion, and is inhibited by Cdc42 and Rac1.; Function: human IQGAP1 is an effector for Cdc42 and Rac1 and has been shown to regulate cadherin function through its interaction with beta-catenin.; Localization: E-cadherin is required for accumulation of human IQGAP1 at cell-cell junctions.; Regulation: Calmodulin regulates the association of human IQGAP1 with Cdc42 and actin.; Title: strong similarity to cytoskeleton regulator IQGAP1 - Homo sapiens; cytoskeleton; See PMID 9867866; See PMID 10448058; See PMID 10508646; See PMID 10608854; uncharacterized protein 1787508 4982090 An07g08210 Aspergillus niger uncharacterized protein XP_059605397.1 1781991 D 5061 CDS An07g08220 4982091 join(1788199..1788280,1788376..1788407,1788509..1788588,1788664..1788745,1788804..1789415,1789461..1790150) IV 1 NT_166523.1 Complex: human epsin 2 interacts with clathrin,Eps15 and the clathrin adaptor AP-2.; Function: high overexpression of human green fluorescent protein-epsin 2 mislocalizes components of the clathrin coat and inhibits clathrin-mediated endocytosis.; Localization: human epsin 2 is present in a clathrin-coated vesicle fraction, is concentrated in the peri-Golgi region and at the cell periphery of transfected cells.; Title: strong similarity to clathrin associated epsin 2A - Homo sapiens; intracellular transport vesicles; See PMID 10567358; uncharacterized protein 1790150 4982091 An07g08220 Aspergillus niger uncharacterized protein XP_059605398.1 1788199 D 5061 CDS An07g08230 4982092 complement(join(1790718..1790951,1791006..1791073,1791151..1791393,1791488..1791647,1791754..1791844,1791900..1791952,1792173..1792247)) IV 1 NT_166523.1 Catalytic activity: Glutathione transferases convert RX + glutathione to HX + R-S-glutathione.; Function: Rhodococcus isoJ has activity with 1-chloro-2,4-dinitrobenzene and 3,4-dichloro-1-nitrobenzene but not with 1, 2-epoxy-2-methyl-3-butene.; Function: Rhodococcus isoJ is a glutathione S-transferase involved in isoprene (2-methyl-1,3-butadiene) utilization.; Title: strong similarity to glutathione S-transferase isoJ - Rhodococcus sp.; See PMID 10715003; uncharacterized protein 1792247 4982092 An07g08230 Aspergillus niger uncharacterized protein XP_059605399.1 1790718 R 5061 CDS An07g08240 4982093 complement(1792985..1794319) IV 1 NT_166523.1 Complex: S. cerevisiae NBP2 interacts with Nap1p, a nucleosome assembly factor, as shown by two-hybrid.; Similarity: similarity is from the C-terminal region of the predicted A. niger protein to the N-terminal half of S. cerevisiae NBP2, which is 130 aa shorter.; Title: similarity to Nbp2 - Saccharomyces cerevisiae; See PMID 10767562; uncharacterized protein 1794319 4982093 An07g08240 Aspergillus niger uncharacterized protein XP_001391899.1 1792985 R 5061 CDS An07g08250 4982094 complement(1796259..1797317) IV 1 NT_166523.1 Title: similarity to hypothetical protein 53H1.090 -Neurospora crassa; uncharacterized protein 1797317 4982094 An07g08250 Aspergillus niger uncharacterized protein XP_001391900.1 1796259 R 5061 CDS An07g08260 84591496 join(1797758..1797790,1797858..1798037,1798135..1798235,1798319..1798439) IV 1 NT_166523.1 hypothetical protein 1798439 84591496 An07g08260 Aspergillus niger hypothetical protein XP_059605400.1 1797758 D 5061 CDS An07g08270 84591497 join(1798513..1798601,1798688..1798927,1799058..1799161,1799264..1799327,1799374..1799449,1799796..1799877,1800083..1800159,1800200..1800319) IV 1 NT_166523.1 hypothetical protein 1800319 84591497 An07g08270 Aspergillus niger hypothetical protein XP_059605401.1 1798513 D 5061 CDS An07g08280 4982097 join(1801263..1801499,1801551..1801604,1801679..1802044,1802104..1804451,1804520..1804859) IV 1 NT_166523.1 Catalytic activity: 3-Hydroxy-3-methylglutaryl-CoA reductases convert (R)-mevalonate + CoA + 2 NADP(+) to (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.; Function: G. fujikuroi HMGR is involved in the control of cholesterol biosynthesis as it is the rate-limiting enzyme of the sterol biosynthesis.; Function: G. fujikuroi HMGR is the first specific enzyme of the isoprenoid pathway.; Localization: G. fujikuroi HMGR is an integral membrane protein of the endoplasmic reticulum.; Title: strong similarity to 3-Hydroxy-3-methylglutaryl-CoA reductase HMGR - Gibberella fujikuroi; endoplasmatic reticulum; See PMID 9000379; uncharacterized protein 1804859 4982097 An07g08280 Aspergillus niger uncharacterized protein XP_059605402.1 1801263 D 5061 CDS An07g08290 4982098 join(1807565..1808797,1808854..1809948,1810001..1810399) IV 1 NT_166523.1 Complex: by two-hybrid S. cerevisiae Spa2p interacts with Pea2p and Bud6p (Aip3p), which has been shown previously to interact with actin.; Complex: by two-hybrid S. cerevisiae Spa2p interacts with signal transduction components Ste11p (MAPK kinase [MEK] kinase) and Ste7p (MEK) of the mating signaling pathway as well as with the MEKs Mkk1p and Mkk2p of the Slt2p (Mpk1p) MAPK pathway.; Complex: by two-hybrid S. cerevisiae Spa2p interacts with the Cdc42, Rho1 and proffilin interacting scaffolding proteins Bni1p and Bnr1p.; Function: S. cerevisiae Spa2p is important for polarized morphogenesis during budding, mating, and pseudohyphal growth.; Function: S. cerevisiae Spa2p likely influences morphogenesis by mediating input from MAPK signal transduction cascades to the actin cytosceleton.; Localization: S. cerevisiae Spa2p localizes to growth sites, likely forming an 12S complex with Pea2p and Bud6p which binds to the actin cytosceleton.; Similarity: a central region of ~400 aa from S. cerevisiae SPA2 shows no similarity to the predicted A. niger protein, which is 400 aa shorter.; Title: similarity to actin cytoskeleton organiser Spa2 - Saccharomyces cerevisiae; cytoskeleton; See PMID 9632790; See PMID 9868371; See PMID 10938101; See PMID 11154270; See PMID 2647769; uncharacterized protein 1810399 4982098 An07g08290 Aspergillus niger uncharacterized protein XP_001391904.1 1807565 D 5061 CDS An07g08300 4982099 join(1811801..1811861,1812096..1812265,1812346..1812452,1812512..1812698) IV 1 NT_166523.1 Function: peptidyl-prolyl cis-trans isomerases influence proline conformation and thereby protein structure, playing critical roles in many cellular functions like arrangement of protein complexes, stress response or signal transduction.; Gene-ID: cypA; Remark: a splice site was detected upstream of the START codon.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_1816, 3552, 2103, 0716, 3379 and 1375.; See PMID 11810223; cyclophilin-like peptidyl prolyl cis-trans isomerase cypA-Aspergillus niger 1812698 cypA 4982099 cypA Aspergillus niger cyclophilin-like peptidyl prolyl cis-trans isomerase cypA-Aspergillus niger XP_001391905.3 1811801 D 5061 CDS An07g08310 4982100 complement(join(1814224..1814266,1814332..1814539,1814684..1814848,1814913..1814943,1814999..1815058)) IV 1 NT_166523.1 Complex: S. pombe Ctr4 and Ctr5 associate in vivo,forming a heteromeric plasma membrane complex.; Function: S. pombe Ctr4 is a subunit of the high affinity copper transporter.; Localization: S. pombe Ctr4 and Ctr5 are interdependent for secretion to the plasma membrane.; Regulation: expression of S. pombe Ctr4 is regulated by copper levels and the copper-sensing transcription factor Cuf1.; Title: similarity to high affinity copper transporter ctr4p - Schizosaccharomyces pombe; plasma membrane; See PMID 11274192; uncharacterized protein 1815058 4982100 An07g08310 Aspergillus niger uncharacterized protein XP_059605403.1 1814224 R 5061 CDS An07g08320 4982101 complement(join(1815619..1815756,1815802..1815910,1815929..1816129,1816201..1816499)) IV 1 NT_166523.1 Catalytic activity: Polyribonucleotide nucleotidyltransferases convert {RNA}(N+1) + phosphat to {RNA}(N) + a nucleoside diphosphate.; Complex: S. cerevisiae Ski6 is a component of the exosome multienzyme ribonuclease complex composed of at least 11 proteins; rrp4, rrp40, rrp41/ski6, rrp42, rrp43,rrp44/dis3, rrp45, rrp46, mtr3, csl4 and rrp6 (only in the nuclear complex).; Function: S. cerevisiae SKI6 is a exosome subunit and thereby involved in the processing of all RNA species.; Function: S. cerevisiae ski6-2 mutants accumulate a 38S particle, apparently an incomplete or degraded 60S ribosomal subunit, containing the 3'-terminus of 25S rRNA but no 5. 8S rRNA.; Function: primary effect of S. cerevisiae Ski6p was on efficiency of translation, as ski6 mutations bypass the requirement of the poly(A) tail for translation.; Localization: the exosome localises to nucleus and cytosol.; Remark: alternative names for S. cerevisiae SKI6 are ECM20, RRP41 and YGR195w.; Title: strong similarity to 3-5 exoribonuclease Ski6 - Saccharomyces cerevisiae; See PMID 9566888; See PMID 10571176; See PMID 10930416; uncharacterized protein 1816499 4982101 An07g08320 Aspergillus niger uncharacterized protein XP_059605404.1 1815619 R 5061 CDS An07g08330 4982102 join(1816875..1816989,1817054..1819980) IV 1 NT_166523.1 Complex: human CSB is a DNA-binding protein, and it also binds to XPA, TFIIH, and the p34 subunit of TFIIE.; Function: human CSB has an ATPase activity that is stimulated strongly by DNA; however, it neither acts as a helicase nor does it dissociate stalled RNA polymerase II.; Function: human CSB is involved in UV induced DNA-repair and likely plays a role in recruiting repair proteins to ternary complexes formed at damage sites.; Title: strong similarity to transcription-repair coupling factor CSB/ERCC6 - Homo sapiens; nucleus; See PMID 8999876; uncharacterized protein 1819980 4982102 An07g08330 Aspergillus niger uncharacterized protein XP_001391908.1 1816875 D 5061 CDS An07g08340 4982103 complement(join(1821188..1821437,1821488..1821801,1821850..1822099,1822149..1822427,1822495..1822605,1822668..1822773,1822885..1823002)) IV 1 NT_166523.1 Function: different OSBPs have different functions,like mediation of sterol and phospholipid synthesis (HES1) or regulation of the Sec14p pathway for Golgi-derived vesicle transport (KES1).; Function: mutations in S. cerevisiae hes1 result in pleiotropic sterol-related phenotypes.; Function: oxysterol binding proteins (OSBPs) are a family of eukaryotic intracellular lipid receptors.; Similarity: S. cerevisiae HES1 and the predicted A. niger protein show strong similarity to human oxysterol binding protein (OSBP) and several putative fungal OSBPs.; Title: similarity to ergosterol synthesis protein Hes1 - Saccharomyces cerevisiae; See PMID 11279184; See PMID 8017104; uncharacterized protein 1823002 4982103 An07g08340 Aspergillus niger uncharacterized protein XP_001391909.1 1821188 R 5061 CDS An07g08350 4982104 complement(join(1824193..1824333,1824417..1824601,1824697..1824879,1824957..1825218)) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein YPL067c - Saccharomyces cerevisiae; uncharacterized protein 1825218 4982104 An07g08350 Aspergillus niger uncharacterized protein XP_001391910.1 1824193 R 5061 CDS An07g08360 4982105 complement(join(1826050..1826709,1826769..1826819)) IV 1 NT_166523.1 Catalytic activity: nicotinamidases convert nicotinamide + H(2)O to nicotinate + NH(3).; Function: E. coli pncA is involved in Pyridine nucleotide cycle.; Title: similarity to pyrazinamidase/nicotinamidase pncA - Escherichia coli; See PMID 8726014; uncharacterized protein 1826819 4982105 An07g08360 Aspergillus niger uncharacterized protein XP_001391911.1 1826050 R 5061 CDS An07g08370 4982106 join(1827816..1828205,1828251..1828616) IV 1 NT_166523.1 Complex: S. cerevisiae Ssu72 protein interacts directly with purified RNA-Pol II in a coimmunoprecipitation assay.; Function: in S. cerevisiae a mutation in RNA-Pol II (rpb2-100) was isolated as a suppressor of the ssu72-2 Ts(-) defect, but enhanced the transcriptional defects associated with ssu72-2.; Function: in S. cerevisiae a recessive ssu72-1 allele was identified as a synthetic enhancer of a TFIIB (sua7-1) defect, resulting in a heat-sensitive (Ts(-)) phenotype and a dramatic downstream shift in transcription start site selection.; Function: in S. cerevisiae the ssu72-2 and rpb2-100 mutations adversely affected noninduced gene expression,with no apparent effects on activated transcription in vivo.; Remark: a splice site was detected upstream of the START codon.; Remark: the systematic name for S. cerevisiae SSU72 isYNL222w.; Title: strong similarity to RNA-Pol II interacting Ssu72 - Saccharomyces cerevisiae; See PMID 11046131; uncharacterized protein 1828616 4982106 An07g08370 Aspergillus niger uncharacterized protein XP_059605405.1 1827816 D 5061 CDS An07g08380 4982107 complement(1829315..1830769) IV 1 NT_166523.1 Function: S. cerevisiae HOS2 is a histone deacetylase.; Function: in S. cerevisiae phenotypes caused by mutations in the histone acetylases gcn5 and elp3 are suppressed by concomitant mutation of the HDA1 and HOS2 histone deacetylases.; Remark: the systematic name for S. cerevisiae HOS2 is YGL194c.; Title: strong similarity to histone deacetylase Hos2 - Saccharomyces cerevisiae; See PMID 10856249; See PMID 8962081; uncharacterized protein 1830769 4982107 An07g08380 Aspergillus niger uncharacterized protein XP_001391913.1 1829315 R 5061 CDS An07g08390 4982108 join(1831510..1831644,1831704..1832480) IV 1 NT_166523.1 Function: carboxyphosphonoenolpyruvate mutase catalyses the formation of one of the two C-P bonds in bialaphos (L-phosphinothricinyl-L-alanyl-L-alanine), a potent herbicide isolated from Streptomyces hygroscopicus.; Title: strong similarity to carboxyphosphonoenolpyruvate mutase - Streptomyces hygroscopicus; See PMID 1330557; uncharacterized protein 1832480 4982108 An07g08390 Aspergillus niger uncharacterized protein XP_001391914.3 1831510 D 5061 CDS An07g08400 4982109 1835069..1836058 IV 1 NT_166523.1 Title: strong similarity to allergen rAsp f 4 -Aspergillus fumigatus; See PMID 10482834; uncharacterized protein 1836058 4982109 An07g08400 Aspergillus niger uncharacterized protein XP_059605406.1 1835069 D 5061 CDS An07g08410 84591498 complement(join(1837473..1838000,1838031..1838090)) IV 1 NT_166523.1 Title: weak similarity to hypothetical protein encoded by An11g06480 - Aspergillus niger; uncharacterized protein 1838090 84591498 An07g08410 Aspergillus niger uncharacterized protein XP_059605407.1 1837473 R 5061 CDS An07g08420 84591499 join(1839064..1839363,1839712..1839755,1839785..1839845,1840531..1840582,1840654..>1840727) IV 1 NT_166523.1 Remark: ORF 3'truncated due to end of contig.; hypothetical protein [truncated ORF] 1840727 84591499 An07g08420 Aspergillus niger hypothetical protein [truncated ORF] XP_059605408.1 1839064 D 5061 CDS An07g08430 4982112 complement(join(<1840830..1841154,1841231..1841369,1841476..1841626)) IV 1 NT_166523.1 Complex: a yeast two-hybrid screen with metaxin 1 as bait has identified a novel protein, termed metaxin 2, as a metaxin 1-binding protein.; Function: in cell culture overexpression of human metaxin resulted in impaired mitochondrial import of natural and chimeric preproteins and in their accumulation.; Function: metaxin is an outer membrane protein of mammalian mitochondria which is suggested to be involved in protein import into the organelle.; Remark: ORF 3'truncated due to end of contig.; Title: strong similarity to mitochondrial preprotein import complex subunit metaxin MTX - Homo sapiens [truncated ORF]; localisation:mitochondrion; See PMID 8660965; See PMID 10381257; See PMID 11027586; uncharacterized protein 1841626 4982112 An07g08430 Aspergillus niger uncharacterized protein XP_001391918.3 1840830 R 5061 CDS An07g08440 84591500 join(1842668..1842740,1842788..1842813,1842986..1843034,1843108..1843158,1843368..1843521,1843635..1843652,1843689..1843776) IV 1 NT_166523.1 hypothetical protein 1843776 84591500 An07g08440 Aspergillus niger hypothetical protein XP_059601046.1 1842668 D 5061 CDS An07g08450 84591501 complement(join(1847102..1847181,1847247..1847310,1847454..1847510,1847805..1847906)) IV 1 NT_166523.1 hypothetical protein 1847906 84591501 An07g08450 Aspergillus niger hypothetical protein XP_059601047.1 1847102 R 5061 CDS An07g08460 84591502 join(1848410..1848531,1848567..1848666,1848931..1849161,1849328..1849657) IV 1 NT_166523.1 hypothetical protein 1849657 84591502 An07g08460 Aspergillus niger hypothetical protein XP_059601048.1 1848410 D 5061 CDS An07g08470 4982116 complement(join(1850632..1851161,1851262..1851490)) IV 1 NT_166523.1 Title: similarity to hypothetical protein G17B7.120 - Neurospora crassa; uncharacterized protein 1851490 4982116 An07g08470 Aspergillus niger uncharacterized protein XP_059601049.1 1850632 R 5061 CDS An07g08480 84591503 join(<1852108..1852224,1852313..1852353,1852423..1852498) IV 1 NT_166523.1 Remark: N-terminally truncated due to contig border.; hypothetical protein [truncated ORF] 1852498 84591503 An07g08480 Aspergillus niger hypothetical protein [truncated ORF] XP_059601050.1 1852108 D 5061 CDS An07g08490 4982118 join(1853487..1853855,1853912..1856554) IV 1 NT_166523.1 Function: the 3'-5' helicase PcrA unwinds helical DNA substrates coupled to the hydrolysis of ATP.; Remark: the crystal structure of a monomeric form of the DNA helicase PcrA from Bacillus stearothermophilus,alone and in a complex with ADP, at 2. 5 and 2. 9 A resolution, has been solved.; Similarity: PcrA belongs to the UvrD subfamily of helicases.; Title: similarity to ATP-dependent helicase pcrA -Bacillus stearothermophilus; nucleus; See PMID 8934527; See PMID 9592155; uncharacterized protein 1856554 4982118 An07g08490 Aspergillus niger uncharacterized protein XP_001391924.1 1853487 D 5061 CDS An07g08500 84591504 complement(join(1856645..1856780,1856821..1856908,1857124..1857194,1857238..1857269,1857365..1857461,1857827..1857874,1857916..1857969,1858234..1858376,1858789..1858857,1858930..1859060,1859191..1859425)) IV 1 NT_166523.1 Title: weak similarity to Vpr binding protein HHR23A from patent WO9835032-A2 - Homo sapiens; uncharacterized protein 1859425 84591504 An07g08500 Aspergillus niger uncharacterized protein XP_059601051.1 1856645 R 5061 CDS An07g08510 84591505 join(1860618..1860721,1861129..1861684) IV 1 NT_166523.1 hypothetical protein 1861684 84591505 An07g08510 Aspergillus niger hypothetical protein XP_059601052.1 1860618 D 5061 CDS An07g08520 4982121 complement(1863906..1865162) IV 1 NT_166523.1 Complex: CCN1 interacts with the CDC2 protein kinase to form MPF.; Function: CCN1 is essential for the control of the cell cycle at the G1/S (Start) transition.; Similarity: CCN1 belongs to the cyclin family.; Title: similarity to G1/S-specific cyclin CCN1 -Candida albicans; See PMID 1409649; See PMID 7830719; uncharacterized protein 1865162 4982121 An07g08520 Aspergillus niger uncharacterized protein XP_001391927.1 1863906 R 5061 CDS An07g08533 84591506 complement(join(1866853..1867058,1867283..1867382)) IV 1 NT_166523.1 hypothetical protein 1867382 84591506 An07g08533 Aspergillus niger hypothetical protein XP_059601053.1 1866853 R 5061 CDS An07g08540 84591507 join(1868955..1869006,1869101..1869123,1869165..1869278) IV 1 NT_166523.1 hypothetical protein 1869278 84591507 An07g08540 Aspergillus niger hypothetical protein XP_059601054.1 1868955 D 5061 CDS An07g08550 84591508 complement(join(1870326..1870527,1870728..1870865,1871032..1871187,1871342..1871480,1872014..1872101,1872239..1872293,1872432..1872521,1872633..1872661)) IV 1 NT_166523.1 hypothetical protein 1872661 84591508 An07g08550 Aspergillus niger hypothetical protein XP_059601055.1 1870326 R 5061 CDS An07g08560 84591509 join(1872671..1872739,1873393..1873458,1873864..1874025) IV 1 NT_166523.1 hypothetical protein 1874025 84591509 An07g08560 Aspergillus niger hypothetical protein XP_059601056.1 1872671 D 5061 CDS An07g08570 84591510 complement(join(1874747..1874825,1874937..1875069,1875158..1875241,1875361..1875448)) IV 1 NT_166523.1 hypothetical protein 1875448 84591510 An07g08570 Aspergillus niger hypothetical protein XP_059601057.1 1874747 R 5061 CDS An07g08580 84591511 complement(join(1876352..1876546,1876587..1876649,1876728..1876789,1876922..1876973,1877052..1877247,1877317..1877393)) IV 1 NT_166523.1 Title: weak similarity to RAD1 binding protein from patent WO9949042-A1 - Mus sp.; uncharacterized protein 1877393 84591511 An07g08580 Aspergillus niger uncharacterized protein XP_059601058.1 1876352 R 5061 CDS An07g08590 4982128 join(1877996..1878416,1878480..1879049,1879105..1879334,1879387..1880970) IV 1 NT_166523.1 Title: strong similarity to protein SEQ ID NO:7145 from patent WO200253728-A2 - Candida albicans; uncharacterized protein 1880970 4982128 An07g08590 Aspergillus niger uncharacterized protein XP_059601059.1 1877996 D 5061 CDS An07g08600 4982129 complement(join(1882450..1882479,1882628..1882780,1882856..1884214)) IV 1 NT_166523.1 Protein sequence is in conflict with the conceptual translation; Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate.; Function: PPZ1 plays a role in regulating osmotic stability.; Title: strong similarity to phosphoprotein phosphatase Ppz2 - Saccharomyces cerevisiae [putative sequencing error]; putative sequencing error; See PMID 8395014; See PMID 8396031; uncharacterized protein 1884214 4982129 An07g08600 Aspergillus niger uncharacterized protein XP_001391935.3 1882450 R 5061 CDS An07g08610 4982130 complement(join(1885636..1885792,1886026..1886094,1886142..1886473,1886558..1886716,1886842..1886952)) IV 1 NT_166523.1 Title: weak similarity to ovarian tumor EST fragment encoded protein 57 from patent DE19817557-A1 - Homo sapiens; uncharacterized protein 1886952 4982130 An07g08610 Aspergillus niger uncharacterized protein XP_059601060.1 1885636 R 5061 CDS An07g08620 4982131 complement(join(1887843..1888246,1888307..1888469)) IV 1 NT_166523.1 Title: similarity to hypothetical protein AAN74824.1 - Gibberella moniliformis; uncharacterized protein 1888469 4982131 An07g08620 Aspergillus niger uncharacterized protein XP_001391937.1 1887843 R 5061 CDS An07g08630 4982132 join(1889351..1889505,1889562..1889630,1889689..1890126,1890277..1890562) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein At2g25280 - Arabidopsis thaliana; uncharacterized protein 1890562 4982132 An07g08630 Aspergillus niger uncharacterized protein XP_059601061.1 1889351 D 5061 CDS An07g08640 4982133 join(1892341..1892484,1892534..1893062,1893120..1893345,1893403..1894018) IV 1 NT_166523.1 Function: mutA of P. purporogenum hydrolysis 1,3-alpha-D-glucosidic links.; Remark: P purporogenum mutA is also named alpha1,3-glucanase.; Title: strong similarity to mutanase mutA -Penicillium purporogenum; See PMID 10636904; uncharacterized protein 1894018 4982133 An07g08640 Aspergillus niger uncharacterized protein XP_001391939.3 1892341 D 5061 CDS An07g08650 4982134 join(1895222..1895282,1895353..1895674,1895730..1896183) IV 1 NT_166523.1 hypothetical protein 1896183 4982134 An07g08650 Aspergillus niger hypothetical protein XP_001391940.1 1895222 D 5061 CDS An07g08660 84591512 join(1897193..1897266,1897340..1897484) IV 1 NT_166523.1 hypothetical protein 1897484 84591512 An07g08660 Aspergillus niger hypothetical protein XP_059601062.1 1897193 D 5061 CDS An07g08670 4982136 join(1898222..1898620,1898660..1899697,1899751..1900077) IV 1 NT_166523.1 Remark: similarities correspond to multiple serine repeats.; Title: weak similarity to hypothetical protein RtoA - Dictyostelium discoideum; uncharacterized protein 1900077 4982136 An07g08670 Aspergillus niger uncharacterized protein XP_059601063.1 1898222 D 5061 CDS An07g08680 84591513 complement(join(1901114..1901217,1901277..1901355,1901449..1901487,1901524..1901676)) IV 1 NT_166523.1 Title: weak similarity to hypothetical protein encoded by CG15782 - Drosophila melanogaster; uncharacterized protein 1901676 84591513 An07g08680 Aspergillus niger uncharacterized protein XP_059601064.1 1901114 R 5061 CDS An07g08690 4982138 complement(join(1903596..1904011,1904061..1904461,1904523..1904815)) IV 1 NT_166523.1 Catalytic activity: the S. cerevisiae homolog Png1p hydrolyses an N4-(acetyl-beta-D-glucosaminyl)asparagine residue to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue.; Title: similarity to cytoplasmic peptide:N-glycanase Png1 - Saccharomyces cerevisiae; cytoplasm; See PMID 10831608; uncharacterized protein 1904815 4982138 An07g08690 Aspergillus niger uncharacterized protein XP_001391944.3 1903596 R 5061 CDS An07g08710 4982139 complement(join(1910126..1910177,1910240..1910579,1910634..1911004,1911056..1911431,1911553..1911856)) IV 1 NT_166523.1 Catalytic activity: UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate; Gene-ID: tpsB; See PMID 8666204; See PMID 9006911; alpha, alpha-trehalose-phosphate synthase (UDP-forming) 2 (trehalose-6-phosphate UDP-glucose phosphate glucosyltransferase) tpsB-Aspergillus niger 1911856 tpsB 4982139 tpsB Aspergillus niger alpha, alpha-trehalose-phosphate synthase (UDP-forming) 2 (trehalose-6-phosphate UDP-glucose phosphate glucosyltransferase) tpsB-Aspergillus niger XP_001391945.1 1910126 R 5061 CDS An07g08720 4982140 join(1913216..1913238,1913295..1914630,1914688..1916118) IV 1 NT_166523.1 Catalytic activity: UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate; Title: strong similarity to 123K chain alpha,alpha-trehalose-phosphate synthase (UDP-forming) Tsl1 -Saccharomyces cerevisiae; See PMID 8404905; See PMID 8850521; See PMID 9837904; uncharacterized protein 1916118 4982140 An07g08720 Aspergillus niger uncharacterized protein XP_001391946.1 1913216 D 5061 CDS An07g08730 4982141 complement(join(1917328..1917946,1918002..1919082,1919145..1919381,1919448..1919550,1919633..1919648,1919690..1919820)) IV 1 NT_166523.1 Complex: CAF-1 contains three subunits p150, p60,and p48.; Complex: only a fraction of total human p48 is associated with p150 and p60, and the majority is present in other high molecular weight complexes.; Function: CAF-1 (Chromatin Assembly Factor-I) efficiently mediates nucleosome assembly during complementary DNA strand synthesis in G1, S, and G2 phase.; Localization: during S phase, human p150 and p60 are concentrated at sites of intranuclear DNA replication.; Localization: in interphase, human p150 and p60 are bound to the nucleus, but they predominantly dissociate from chromatin during mitosis.; Regulation: in mitosis, the human p60 subunit of inactive CAF-1 is hyperphosphorylated, whereas active CAF-1 in interphase contains hypophosphorylated and/or phosphorylated forms of p60.; Title: strong similarity to chromatin assembly factor-I (CAF-I) p60 subunit Cac2 - Saccharomyces cerevisiae; nucleus; See PMID 9614144; See PMID 9927445; uncharacterized protein 1919820 4982141 An07g08730 Aspergillus niger uncharacterized protein XP_059601065.1 1917328 R 5061 CDS An07g08740 4982142 complement(join(1920798..1921256,1921344..1921829)) IV 1 NT_166523.1 Remark: in T. brucei strain 427 ISG75 genes are present in tandem arrays at two loci, A and B, containing 5 and 2 copies, respectively.; Title: weak similarity to 75 kDa invariant surface glycoprotein ISG75 - Trypanosoma brucei; See PMID 1587856; uncharacterized protein 1921829 4982142 An07g08740 Aspergillus niger uncharacterized protein XP_001391948.1 1920798 R 5061 CDS An07g08750 4982143 join(1922420..1922512,1922698..1922903,1923081..1923442,1923492..1925120,1925179..1925771,1925836..1926084) IV 1 NT_166523.1 Similarity: the predicted A. niger protein shows also similarity to different proline, glutamic acid and glutamine rich structural proteins, like Neurofilament triplet H1 and extensins.; Title: weak similarity to protein OlpB from patent FR2748479-A1 - Clostridium thermocellum; uncharacterized protein 1926084 4982143 An07g08750 Aspergillus niger uncharacterized protein XP_059601066.1 1922420 D 5061 CDS An07g08760 4982144 1927443..1928552 IV 1 NT_166523.1 Catalytic activity: NADPH dehydrogenases catalyse the reaction, NADPH + acceptor = NADP+ + reduced acceptor.; Complex: S. cerevisiae OYE3 forms homodimers and heterodimers with other OYE Isoforms.; Function: S. cerevisiae OYE3 binds a variety of compounds with a phenolic structure.; Function: S. cerevisiae OYE3 has been shown to catalyze efficiently the NADPH-linked reduction of nitro-olefins.; Function: S. cerevisiae OYE3 might be involved in sterol metabolism.; Title: strong similarity to hypothetical NADPH dehydrogenase Oye3 - Saccharomyces cerevisiae; See PMID 10995477; uncharacterized protein 1928552 4982144 An07g08760 Aspergillus niger uncharacterized protein XP_001391950.1 1927443 D 5061 CDS An07g08770 4982145 complement(join(1928671..1928682,1928734..1929689,1929735..1929772,1929818..1929926,1929971..1930132,1930188..1930431)) IV 1 NT_166523.1 Induction: in S. cerevisiae the relatively high basal level of DAL5 expression did not increase further upon addition of allantoin pathway intermediates.; Repression: in S. cerevisiae steady-state DAL5 mRNA levels dropped precipitously when a repressive nitrogen source was provided.; Similarity: DAL5 from S. cerevisiae is a member of the major facilitator family.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 3275614; uncharacterized protein 1930431 4982145 An07g08770 Aspergillus niger uncharacterized protein XP_001391951.1 1928671 R 5061 CDS An07g08780 84591514 join(1935001..1935006,1935079..1935104,1935147..1935187,1935221..1935291) IV 1 NT_166523.1 Remark: ORF classified questionable due to lack of similarities and length < 80 aa.; Title: questionable ORF; uncharacterized protein 1935291 84591514 An07g08780 Aspergillus niger uncharacterized protein XP_059601067.1 1935001 D 5061 CDS An07g08790 84591515 complement(join(1935825..1936036,1936074..1936080)) IV 1 NT_166523.1 Remark: predicted A. niger protein is 300 aa shorter than wee1 from S. pombe.; Title: weak similarity to mitosis inhibitor protein kinase wee1p - Schizosaccharomyces pombe; uncharacterized protein 1936080 84591515 An07g08790 Aspergillus niger uncharacterized protein XP_059601068.1 1935825 R 5061 CDS An07g08800 84591516 complement(join(1936514..1936974,1937169..1937178,1937320..1937435,1937646..1937700,1937768..1937812,1938056..1938119,1938153..1938325,1938360..1938397,1938778..1938874,1939021..1939119)) IV 1 NT_166523.1 Function: it has been suggested, that Hwp1 from C. albicans is a glucan-linked protein with serine/threonine-rich regions that are predicted to function in extending a ligand-binding domain into the extracellular space.; Title: weak similarity to hyphal wall protein 1 HWP1 - Candida albicans; See PMID 9639315; uncharacterized protein 1939119 84591516 An07g08800 Aspergillus niger uncharacterized protein XP_059601069.1 1936514 R 5061 CDS An07g08810 4982149 join(1939978..1940354,1940413..1940581,1940637..1940957) IV 1 NT_166523.1 Complex: Gpr1 from S. cerevisiae binds to the G-protein Gpa2.; Function: in S. cerevisiae gpr1 is a nutrient sensor that regulates pseudohyphal differentiation.; Induction: in S. cerevisiae expression of the GPR1 gene is known to be induced by nitrogen starvation.; Induction: in S. cerevisiae the gpr1 receptor is activated by glucose and other structurally related sugars.; Pathway: in S. cerevisiae epistasis analysis supports a model in which the Gpr1 receptor regulates pseudohyphal growth via the Gpa2p-cAMP-PKA pathway and independently of both the MAP kinase cascade and the PKA related kinase Sch9.; Title: strong similarity to G protein-coupled receptor Gpr1 - Saccharomyces cerevisiae; plasma membrane; See PMID 10655215; uncharacterized protein 1940957 4982149 An07g08810 Aspergillus niger uncharacterized protein XP_001391955.1 1939978 D 5061 CDS An07g08820 4982150 complement(join(1942692..1943439,1943495..1943610,1943657..1943973,1944050..1944965)) IV 1 NT_166523.1 Function: PAK family kinases regulate cytoskeletal changes mediated by Cdc42 and Rac.; Function: experiments in D. discoideum suggest that the assembly of myosin II into the cytoskeleton requires PAKa function.; Function: in D. discoideum paka null cells or wild-type cells expressing a kinase dead (putative dominant negative) PAKa produce many random, lateral pseudopodia and have a much higher frequency of making wrong turns than wild-type cells.; Localization: PAKa colocalizes with myosin II to the cleavage furrow of dividing cells and the posterior of polarized, chemotaxing cells via its NH(2)-terminal domain.; Similarity: the predicted A. niger protein shows similarity to central region of DPAKA, which is 500 aa longer.; Similarity: the predicted A. niger protein shows similarity to serine and proline rich proteins.; Title: weak similarity to hypothetical protein LcoB - Lactococcus lactis; uncharacterized protein 1944965 4982150 An07g08820 Aspergillus niger uncharacterized protein XP_059601070.1 1942692 R 5061 CDS An07g08830 4982151 complement(join(1950548..1951800,1951854..1951965,1952022..1952212,1952268..1952505,1952583..1952630)) IV 1 NT_166523.1 Complex: YAP180 from S. cerevisiae binds Pan1p and clathrin.; Function: AP deletion strains in S. cerevisiae suggest that clathrin function and recruitment onto membranes are not dependent upon heterotetrameric adaptors or AP180 homologs.; Localization: in S. cerevisiae yAP180 proteins and Pan1p, like actin, localize to peripheral patches along the plasma membrane.; Remark: YGR241C is the systematic name for YAP180.; Similarity: YAP180 from S. cerevisiae is a member of the AP180 protein family.; Title: strong similarity to adaptor protein Yap180 -Saccharomyces cerevisiae; cytoskeleton; See PMID 10406795; uncharacterized protein 1952630 4982151 An07g08830 Aspergillus niger uncharacterized protein XP_001391957.1 1950548 R 5061 CDS An07g08840 4982152 join(1953802..1954293,1954354..1954750,1954808..1955016,1955071..1955766) IV 1 NT_166523.1 Similarity: only C-terminal region of predicted A. niger protein shows similarity to human WDR9, which is 1700 aa longer.; Title: weak similarity to hypothetical WDR9 - Homo sapiens; uncharacterized protein 1955766 4982152 An07g08840 Aspergillus niger uncharacterized protein XP_059601071.1 1953802 D 5061 CDS An07g08850 4982153 complement(join(1956291..1956358,1956520..1956759,1957106..1957280)) IV 1 NT_166523.1 Complex: RPS11B from S. cerevisiae is a component of the cytosolic small ribosomal subunit 40S.; Function: RPS11B from S. cerevisiae is a structural protein of the ribosome and controls translational accuracy as well as ribosomal small subunit assembly and maintenance.; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit Rps11b - Saccharomyces cerevisiae; cytoplasm; 40S ribosomal protein uS17 1957280 4982153 An07g08850 Aspergillus niger 40S ribosomal protein uS17 XP_059601072.1 1956291 R 5061 CDS An07g08860 4982154 join(1957977..1958382,1958436..>1960693) IV 1 NT_166523.1 Remark: ORF C-terminally truncated due to end of contig.; Similarity: predicted A. niger protein shows unspecific similarity to serine and glutamic acid rich proteins.; Title: weak similarity to dentin phosphophoryn -Homo sapiens [truncated ORF]; uncharacterized protein 1960693 4982154 An07g08860 Aspergillus niger uncharacterized protein XP_001391960.3 1957977 D 5061 CDS An07g08870 4982155 complement(join(1960899..1961895,1961958..1962509,1962592..1963264,1963325..1963764,1963899..1963909)) IV 1 NT_166523.1 Remark: ntf1 plays an important role in regulating nmt1 expression, which is subject to transcriptional repression mediated by thiamine in Schizosaccharomyces pombe.; Title: similarity to transcription factor ntf1p -Schizosaccharomyces pombe; nucleus; See PMID 8163491; uncharacterized protein 1963909 4982155 An07g08870 Aspergillus niger uncharacterized protein XP_059603821.1 1960899 R 5061 CDS An07g08880 4982156 join(1969138..1969402,1970100..1970638) IV 1 NT_166523.1 Remark: cys-3, the positive-acting master sulfur regulatory gene of Neurospora crassa, turns on the expression of an entire set of unlinked structural genes which encode sulfur-catabolic enzymes.; Title: strong similarity to positive sulphur regulator CYS3 - Neurospora crassa; nucleus; See PMID 2142156; See PMID 2524646; uncharacterized protein 1970638 4982156 An07g08880 Aspergillus niger uncharacterized protein XP_001391962.1 1969138 D 5061 CDS An07g08890 4982157 complement(join(1972696..1973309,1973368..1973551,1973613..1973746,1973897..1974014)) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein YGR086c - Saccharomyces cerevisiae; uncharacterized protein 1974014 4982157 An07g08890 Aspergillus niger uncharacterized protein XP_001391963.1 1972696 R 5061 CDS An07g08900 4982158 join(1976179..1976238,1976292..1977055,1977107..1978985,1979031..1979715,1979790..1980034) IV 1 NT_166523.1 Title: similarity to hypothetical WD-repeat protein WDR6 - Homo sapiens; uncharacterized protein 1980034 4982158 An07g08900 Aspergillus niger uncharacterized protein XP_059603822.1 1976179 D 5061 CDS An07g08910 4982159 complement(join(<1981277..1982163,1982286..1982678,1982708..1982901,1982972..1984204)) IV 1 NT_166523.1 Catalytic activity: NAD(P)H + Nitrate = NAD(P)+ + Nitrite + H2O.; Title: strong similarity to nitrate reductase NR1 -Zea mays [putative frameshift]; putative frameshift; See PMID 9576798; See PMID 10773339; See PMID 11244107; uncharacterized protein 1984204 4982159 An07g08910 Aspergillus niger uncharacterized protein XP_059603823.1 1981277 R 5061 CDS An07g08920 4982160 complement(join(1986089..1986129,1986180..1986730,1986779..1987109,1987144..1988728,1988765..1989118,1989211..1989495)) IV 1 NT_166523.1 Catalytic activity: NAD(P)H + Nitrate = NAD(P)+ + Nitrite + H2O.; Title: strong similarity to nitrate reductase NR -Betula pendula; See PMID 1675424; uncharacterized protein 1989495 4982160 An07g08920 Aspergillus niger uncharacterized protein XP_059603824.1 1986089 R 5061 CDS An07g08930 4982161 complement(join(1989945..1990057,1990136..1990325,1990376..1990997,1991053..1991159,1991230..1991451)) IV 1 NT_166523.1 Catalytic activity: nitrous oxide + H2O + acceptor = 2 nitric oxide + reduced acceptor.; Title: strong similarity to nitric-oxide cytochrome P-450 reductase Cyp55 - Fusarium oxysporum; See PMID 7798191; uncharacterized protein 1991451 4982161 An07g08930 Aspergillus niger uncharacterized protein XP_001391967.3 1989945 R 5061 CDS An07g08940 4982162 join(1993286..1993377,1993524..1993925,1993970..1994225,1994325..1994528) IV 1 NT_166523.1 Similarity: acetyl-esterase I of patent WO9502689-A of A. aculeatus shows acetyl esterase activity on acetylated xylan and mannan; it is used in the preparation of feed or food, and in the paper or pulp industry.; Similarity: shows similarity to several lipases,esterases.; Title: similarity to acetyl-esterase I from patent WO9502689-A - Aspergillus aculeatus; uncharacterized protein 1994528 4982162 An07g08940 Aspergillus niger uncharacterized protein XP_059603825.1 1993286 D 5061 CDS An07g08950 4982163 join(1995122..1995221,1995265..1995320,1995364..1995516,1995562..1995626,1995670..1995767,1995815..1996338) IV 1 NT_166523.1 Catalytic activity: endohydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.; Gene-ID: eglB; extracellular/secretion proteins; See PMID 9758775; endoglucanase B eglB-Aspergillus niger 1996338 eglB 4982163 eglB Aspergillus niger endoglucanase B eglB-Aspergillus niger XP_001391969.1 1995122 D 5061 CDS An07g08960 4982164 join(1998158..1998295,1998360..1999214) IV 1 NT_166523.1 Title: similarity to hypothetical protein SPAC15A10.09c - Schizosaccharomyces pombe; uncharacterized protein 1999214 4982164 An07g08960 Aspergillus niger uncharacterized protein XP_001391970.1 1998158 D 5061 CDS An07g08970 4982165 complement(join(2000178..2004050,2004114..2004263)) IV 1 NT_166523.1 Similarity: blast hits are caused by repetetive sequence motives.; hypothetical protein 2004263 4982165 An07g08970 Aspergillus niger hypothetical protein XP_001391971.1 2000178 R 5061 CDS An07g08980 4982166 join(2005027..2012330,2012427..2012505) IV 1 NT_166523.1 Catalytic activity: Fab1 in S. cerevisiae transfers a phosphate group from ATP to the 5-hydroxyl of phosphatidylinositol-3-phosphate.; Function: Fab1 in S. cerevisiae is regulated by Vac7.; Induction: Fab1 in S. cerevisiae is activated under hyperosmotic stress conditions.; Pathway: Fab1 in S. cerevisiae constitutes the key kinase in a signal transduction pathway involved in vacuolar membrane homeostasis.; Pathway: Fab1 in S. cerevisiae is involved in cargo-selective trafficking from multivesicular bodies to the vacuolar lumen.; Pathway: Fab1 in S. cerevisiae is not required for the biogenesis of the vacuole.; Pathway: the product of Fab1 activity in S. cerevisiae, phosphatidylinositol-3,5-bisphosphate, is a key regulator for vacuolar membrane turnover/recycling.; Remark: phosphatidylinositol 3-phosphate 5-kinases containing the RING-FYVE-finger domain are referred to as Type III PIP-kinases.; Similarity: the strong homology regions include the N-terminal cysteine-rich RING-FYVE-finger zinc-binding domain and the C-terminal PIP-5-kinase domain.; Title: strong similarity to phosphatidylinositol 3-phosphate 5-kinase Fab1 - Saccharomyces cerevisiae; vacuole; See PMID 9763421; See PMID 9811604; See PMID 9865702; See PMID 7663021; uncharacterized protein 2012505 4982166 An07g08980 Aspergillus niger uncharacterized protein XP_059603826.1 2005027 D 5061 CDS An07g08990 4982167 complement(join(2014154..2014399,2014458..2014539,2014589..2015422,2015521..2015642,2015696..2015776,2015832..2015878,2015936..2015980,2016082..2016205)) IV 1 NT_166523.1 Catalytic activity: pyruvate kinases transfer a phosphate group from phosphoenolpyruvate to ADP producing pyruvate and ATP.; Gene-ID: pkiA; Pathway: pyruvate kinases catalyze the last, and irreversible, step of glucose degradation to pyruvate.; cytoplasm; See PMID 1611667; pyruvate kinase pkiA-Aspergillus niger 2016205 pkiA 4982167 pkiA Aspergillus niger pyruvate kinase pkiA-Aspergillus niger XP_001391973.1 2014154 R 5061 CDS An07g09005 4982168 join(2018625..2018627,2018753..2018792,2018863..2018905,2019026..2019167) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein SPAC26A3.14c - Schizosaccharomyces pombe; uncharacterized protein 2019167 4982168 An07g09005 Aspergillus niger uncharacterized protein XP_001391974.1 2018625 D 5061 CDS An07g09010 4982169 complement(join(2020039..2020160,2020220..2021417)) IV 1 NT_166523.1 Similarity: homology to T17H3. 1 from A. thaliana covers only it's C-terminal part.; Similarity: the N-terminus also shows homology to human F-box containing proteins.; Title: weak similarity to hypothetical protein T17H3.1 - Arabidopsis thaliana; uncharacterized protein 2021417 4982169 An07g09010 Aspergillus niger uncharacterized protein XP_001391975.1 2020039 R 5061 CDS An07g09020 4982170 join(2022418..2024674,2024964..2025035,2025118..2025272) IV 1 NT_166523.1 Title: weak similarity to polypeptide SEQ ID NO:3357 from patent WO2003052076-A2 - Cryptococcus neoformans; uncharacterized protein 2025272 4982170 An07g09020 Aspergillus niger uncharacterized protein XP_001391976.3 2022418 D 5061 CDS An07g09030 84591517 join(2025506..2025523,2025578..2025643,2025729..2025850,2025986..2026048,2026141..2026346,2026436..2026525,2026634..2026770) IV 1 NT_166523.1 hypothetical protein 2026770 84591517 An07g09030 Aspergillus niger hypothetical protein XP_059603827.1 2025506 D 5061 CDS An07g09040 4982172 2027277..2029013 IV 1 NT_166523.1 Similarity: shows deliberate matches to a variety of hihgly repetitive proteins.; Title: weak similarity to INSP010 from patent WO2003051919-A1 - Homo sapiens; uncharacterized protein 2029013 4982172 An07g09040 Aspergillus niger uncharacterized protein XP_001391978.3 2027277 D 5061 CDS An07g09050 4982173 join(2030189..2030195,2030280..2030956) IV 1 NT_166523.1 Similarity: the C-terminus is about 120 aa shorter than in SC5F2A. 29 of S. coelicolor.; Title: similarity to hypothetical transcription regulator SC5F2A.29 - Streptomyces coelicolor; uncharacterized protein 2030956 4982173 An07g09050 Aspergillus niger uncharacterized protein XP_059603828.1 2030189 D 5061 CDS An07g09060 4982174 complement(join(2031240..2032633,2032684..2032754,2032934..2032971)) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein CAE76244.1 - Neurospora crassa; uncharacterized protein 2032971 4982174 An07g09060 Aspergillus niger uncharacterized protein XP_059603829.1 2031240 R 5061 CDS An07g09070 4982175 join(2033524..2034007,2034104..2034143,2034288..2034300) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein YMR158w - Saccharomyces cerevisiae; uncharacterized protein 2034300 4982175 An07g09070 Aspergillus niger uncharacterized protein XP_001391981.3 2033524 D 5061 CDS An07g09080 84591518 join(2036120..2036380,2036421..2036484,2036514..2036614) IV 1 NT_166523.1 hypothetical protein 2036614 84591518 An07g09080 Aspergillus niger hypothetical protein XP_059603830.1 2036120 D 5061 CDS An07g09090 4982177 join(2037303..2037397,2037469..2037537,2037623..2038532) IV 1 NT_166523.1 Title: weak similarity to hypothetical protein encoded by An18g02770 - Aspergillus niger; uncharacterized protein 2038532 4982177 An07g09090 Aspergillus niger uncharacterized protein XP_001391983.3 2037303 D 5061 CDS An07g09100 84591519 complement(join(2039943..2039966,2040030..2040090,2040397..2040556,2040668..2040773,2040811..2040964,2041046..2041173)) IV 1 NT_166523.1 hypothetical protein 2041173 84591519 An07g09100 Aspergillus niger hypothetical protein XP_059603831.1 2039943 R 5061 CDS An07g09110 4982179 complement(join(2041370..2042530,2042594..2042808,2042966..2043089)) IV 1 NT_166523.1 Function: the monooxygenase VioC is involved in late steps of violacein biosynthesis.; Remark: the violacein biosynthetic gene cluster spans eight kilobases and is comprised of the four genes,vioABCD, that are necessary for violacein production.; Remark: violacein is a purple-colored,broad-spectrum antibacterial pigment that has a dimeric structure composed of 5-hydroxyindole, oxindole and 2-pyyrolidone subunits formed by the condensation of two modified tryptophan molecules.; Title: similarity to monooxygenase VioC -Chromobacterium violaceum; See PMID 11075927; uncharacterized protein 2043089 4982179 An07g09110 Aspergillus niger uncharacterized protein XP_001391985.1 2041370 R 5061 CDS An07g09120 4982180 join(2043667..2043801,2043888..2043915,2043970..2044286,2044345..2044995) IV 1 NT_166523.1 Function: MAP1 cleaves methionine from nascent polypeptide chains.; Pathway: methionine aminopeptidase is one of the central enzymes in protein synthesis.; Remark: gene models derived from different cDNA sequences suggest alternativ splicing of the first intron. The two proposed alternative N-termini of the protein would be 'MPQGRHGQLLLLAGLFQTELGRLPYVTHQAH SEHKTIHK. . . ' and 'MAEVATRKCMGVDCDKNAGTLQCPTCLKAGTDSFFCSQDCFKRSW SEHKTIHK. . . '.; Similarity: MAP1 consists of two functional domains: a unique NH2-terminal domain containing two motifs resembling zinc fingers, which may allow the protein to interact with ribosomes, and a catalytic COOH-terminal domain resembling prokaryotic methionine aminopeptidases.; Title: strong similarity to precursor of methionyl aminopeptidase Map1 - Saccharomyces cerevisiae; See PMID 1569059; uncharacterized protein 2044995 4982180 An07g09120 Aspergillus niger uncharacterized protein XP_001391986.1 2043667 D 5061 CDS An07g09130 4982181 join(2045876..2046079,2046143..2046400,2046453..2046597,2046649..2046682,2046736..2047409,2047477..2047820) IV 1 NT_166523.1 Title: strong similarity to SRT protein sequence SEQ ID NO:248 from patent WO200100804-A2 - Corynebacterium glutamicum; uncharacterized protein 2047820 4982181 An07g09130 Aspergillus niger uncharacterized protein XP_001391987.1 2045876 D 5061 CDS An07g09140 4982182 2048684..>2051302 IV 1 NT_166523.1 Remark: C-terminally truncated due to contig border.; Title: weak similarity to protein herc2 - Mus musculus [truncated ORF]; uncharacterized protein 2051302 4982182 An07g09140 Aspergillus niger uncharacterized protein XP_001391988.3 2048684 D 5061 CDS An07g09150 4982183 complement(join(2052005..2053633,2053728..2053850)) IV 1 NT_166523.1 Function: PRP17 encodes a protein that participates in the second step of the splicing reaction (is spliceosome-associated) and is required for initiation and completion of S-phase and for initiation and completion of DNA replication.; Remark: PRP17 of S. cerevisiae is identical to the cell division cycle CDC40 gene.; Remark: a yeast-human PRP17 chimera is able to complement the cell cycle and splicing defects of a yeast prp17 mutant.; Similarity: the ORF overlaps with the A. niger EST an_3051 in EMBLEST:BE758807 at it's C-terminus.; Title: strong similarity to splicing factor PRP17 -Homo sapiens; See PMID 9769104; See PMID 9830021; uncharacterized protein 2053850 4982183 An07g09150 Aspergillus niger uncharacterized protein XP_001391989.1 2052005 R 5061 CDS An07g09160 4982184 complement(join(2054559..2054651,2054713..2054779,2054844..2054999,2055146..2055246)) IV 1 NT_166523.1 Function: cni of D. melanogaster is necessary for both anterior-posterior and dorsal-ventral pattern formation.; Function: it is proposed that the cornichon homolog YGL054c (Erv14) of S. cerevisiae is required for formation of COPII-coated ER-derived transport vesicles.; Phenotype: mutations in the cni gene of D. melanogaster prevent the formation of a correctly polarized microtubule cytoskeleton, which is required for proper localization of the anterior and posterior determinants bicoid and oskar and for the asymmetric positioning of the oocyte nucleus.; Remark: cni of D. melanogaster belongs to the cornichon family.; Title: strong similarity to pattern formation protein cni - Drosophila melanogaster; See PMID 9732282; See PMID 7540118; uncharacterized protein 2055246 4982184 An07g09160 Aspergillus niger uncharacterized protein XP_001391990.1 2054559 R 5061 CDS An07g09170 4982185 complement(join(2056236..2056472,2056544..2057492,2057670..2057959,2058011..2059639)) IV 1 NT_166523.1 Function: BCRP1 of M. musculus is a multidrug-resistance protein.; Function: BCRP1 of M. musculus renders tumor cells resistant to the anticancer drugs topotecan, mitoxantrone,doxorubicin, and daunorubicin.; Remark: BCRP1 of M. musculus is a member of the adenosine triphosphate-binding cassette (ABC) family of drug transporters.; Remark: BCRP1 of M. musculus is also designated ABCP and MXR.; Similarity: about 400 N-terminal amino acids of the ORF are not aligned with BCRP1 of M. musculus.; Similarity: the ORF overlaps with the A. niger ESTs an_2679 in EMBLEST:BE759768 and an_2660 in EMBLEST:BE759753.; Title: strong similarity to breast cancer resistance protein 1 BCRP1 - Mus musculus; See PMID 10485464; See PMID 11036110; uncharacterized protein 2059639 4982185 An07g09170 Aspergillus niger uncharacterized protein XP_059601073.1 2056236 R 5061 CDS An07g09180 4982186 join(2060389..2060421,2060492..2060940,2061003..2061735) IV 1 NT_166523.1 Catalytic activity: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.; Complex: the AspAT protein of Thermus aquaticus forms a homodimer.; Remark: AspAT of Thermus aquaticus belongs to class-I of pyridoxal-phosphate-dependent aminotransferases.; Remark: the AspAT protein of Thermus aquaticus is rich in proline residues, and is very thermostabile.; Remark: the AspAT protein of Thermus aquaticus is strictly specific for acidic amino acid substrates, such as aspartate, glutamate, and the respective keto acids.; Similarity: AspAT of Thermus aquaticus shows also similarity to some transaminases of other specificities.; Title: strong similarity to aspartate transaminase AspAT - Thermus aquaticus; See PMID 10029535; See PMID 8907187; uncharacterized protein 2061735 4982186 An07g09180 Aspergillus niger uncharacterized protein XP_059601074.1 2060389 D 5061 CDS An07g09190 4982187 join(2062413..2062428,2062502..2063292,2063350..2064510) IV 1 NT_166523.1 Catalytic activity: ATP + a very long-chain carboxylic acid + CoA = AMP + Pyrophosphate + an Acyl-CoA; Function: the FAT1 protein of S. cerevisiae has,additionally, a very-long-chain acyl-CoA synthetase (VLCS) activity, thus enabling beta-oxidation of very long chain fatty acids.; Function: the FAT1 protein of S. cerevisiae is required for maximal levels of fatty-acid import.; Remark: FAT1 of S. cerevisiae belongs to the ATP-dependent AMP-binding enzyme family.; Similarity: 82 N-terminal amino acids of the ORF are not aligned with FAT1 of S. cerevisiae.; Title: strong similarity to very long-chain fatty acyl-CoA synthase Fat1 - Saccharomyces cerevisiae; See PMID 9660783; See PMID 9988704; See PMID 10880966; See PMID 9079682; uncharacterized protein 2064510 4982187 An07g09190 Aspergillus niger uncharacterized protein XP_001391993.1 2062413 D 5061 CDS An07g09200 4982188 complement(join(2064830..2064946,2065321..2065701,2065759..2065906,2066041..2066229,2066324..2066482,2066506..2066816)) IV 1 NT_166523.1 Function: 2-5A-dependent RNAase of M. musculus is activated by 5'-phosphorylated, 2',5'-linked oligoadenylates (2-5A) and controls RNA stability.; Remark: 2-5A-dependent RNAase of M. musculus is a key enzyme of IFN-induced viral defence.; Similarity: the ORF shows only local similarity (125 aligned amino acids) to 2-5A-dependent RNAase of M. musculus; furthermore the characterized domains of M. musculus 2-5A-dependent RNAase are not included in the alignment.; Title: weak similarity to 2-5A-dependent RNAase -Mus musculus; See PMID 7680958; uncharacterized protein 2066816 4982188 An07g09200 Aspergillus niger uncharacterized protein XP_001391994.3 2064830 R 5061 CDS An07g09210 84591520 join(2067194..2067642,2067752..2067809,2067896..2067913) IV 1 NT_166523.1 Remark: the ORF has an unusual intron/exon structure for A. niger.; hypothetical protein 2067913 84591520 An07g09210 Aspergillus niger hypothetical protein XP_059601075.1 2067194 D 5061 CDS An07g09220 4982190 join(2069830..2070440,2070511..2070985) IV 1 NT_166523.1 Similarity: the ORF shows local similarity to PA0878 of P. aeruginosa: 237 amino acids are aligned.; Title: similarity to hypothetical protein PA0878 -Pseudomonas aeruginosa; uncharacterized protein 2070985 4982190 An07g09220 Aspergillus niger uncharacterized protein XP_001391996.1 2069830 D 5061 CDS An07g09230 4982191 join(2071421..2071476,2071594..2072020,2072205..2072301,2072353..2072384,2072440..2073673,2073719..2073849,2073898..2073984) IV 1 NT_166523.1 Remark: the ORF contains a glutamine-rich stretch.; Remark: the ORF contains many positive charged amino acids.; Remark: the ORF encompasses a zinc-finger and could thus be involved in DNA-binding.; Similarity: the ORF shows local similarity to SPAC1F7. 11c of S. pombe (aligned amino acids: 4-505).; Title: similarity to hypothetical transcription regulator protein CAA91958.1 - Schizosaccharomyces pombe; uncharacterized protein 2073984 4982191 An07g09230 Aspergillus niger uncharacterized protein XP_059601076.1 2071421 D 5061 CDS An07g09240 4982192 join(2074183..2074692,2074747..2074935) IV 1 NT_166523.1 Remark: the ORF shows local strong similarity to SPCC16A11. 07 of S. pombe: 88 N-terminal amino acids of the ORF are excluded from the alignment.; Title: strong similarity to hypothetical protein SPCC16A11.07 - Schizosaccharomyces pombe; uncharacterized protein 2074935 4982192 An07g09240 Aspergillus niger uncharacterized protein XP_059601077.1 2074183 D 5061 CDS An07g09250 4982193 complement(join(2075125..2075631,2075659..2075837,2075910..2076090,2076154..2076213)) IV 1 NT_166523.1 Catalytic activity: 2 peroxide radical + 2 H(+) <=> O(2) + H(2)O(2).; Function: the sodB protein of H. pylori detoxifies radicals.; Phenotype: sodB mutants of H. pylori are devoid of superoxid dismutase (SOD) activity.; Phenotype: sodB mutants of H. pylori are even more sensitive to O2 than wildtype H. pylori; the mutants are also more sensitive to H2O2.; Phenotype: sodB mutants of H. pylori show an increased mutation rate.; Remark: the sodB protein of H. pylori is a virulence factor which affects the ability to colonize the host and is important for the growth and survival of H. pylori under conditions of oxidative stress.; Similarity: the ORF is longer than the sodB protein of H. pylori (308 compared to 213 amino acids) but due to gaps in the alignment it encompasses the whole ORF.; Title: similarity to superoxide dismutase sodB -Helicobacter pylori; See PMID 11349073; mitochondrial 37S ribosomal protein mS42 2076213 4982193 An07g09250 Aspergillus niger mitochondrial 37S ribosomal protein mS42 XP_059601078.1 2075125 R 5061 CDS An07g09260 4982194 2076889..2078142 IV 1 NT_166523.1 hypothetical protein 2078142 4982194 An07g09260 Aspergillus niger hypothetical protein XP_059601079.1 2076889 D 5061 CDS An07g09270 10098323 complement(join(2078252..2078278,2078409..2079803,2079843..2080221,2080260..2080303,2080433..2080676,2080728..2081077)) IV 1 NT_166523.1 Similarity: the ORF shows local strong similarity to the hypothetical protein SPAC1F12. 09 of S. pombe: nearly 300 N-terminal amino acids are not included in the alignment.; Title: strong similarity to hypothetical protein SPAC1F12.09 - Schizosaccharomyces pombe; uncharacterized protein 2081077 10098323 An07g09270 Aspergillus niger uncharacterized protein XP_059601080.1 2078252 R 5061 CDS An07g09280 4982196 join(2081810..2081986,2082043..2083368) IV 1 NT_166523.1 Title: strong similarity to hypothetical transmembrane protein SPAC30D11.11 - Schizosaccharomyces pombe; uncharacterized protein 2083368 4982196 An07g09280 Aspergillus niger uncharacterized protein XP_001392002.1 2081810 D 5061 CDS An07g09290 4982197 join(2083975..2084338,2084555..2085009) IV 1 NT_166523.1 Remark: the ORF has an unusual exon/intron structure for A. niger.; hypothetical protein 2085009 4982197 An07g09290 Aspergillus niger hypothetical protein XP_059601081.1 2083975 D 5061 CDS An07g09300 84591521 complement(join(2086825..2086890,2086968..2087105,2087211..2087339,2087635..2087730)) IV 1 NT_166523.1 Remark: the ORF has an unusual exon/intron structure for A. niger.; hypothetical protein 2087730 84591521 An07g09300 Aspergillus niger hypothetical protein XP_059601082.1 2086825 R 5061 CDS An07g09310 4982199 join(2091234..2091259,2091313..2091517) IV 1 NT_166523.1 Remark: the ORF is short in length.; hypothetical protein 2091517 4982199 An07g09310 Aspergillus niger hypothetical protein XP_001392005.1 2091234 D 5061 CDS An07g09320 4982200 complement(join(2092152..2092974,2093027..2093430)) IV 1 NT_166523.1 Catalytic activity: 2-hydroxymuconate semialdehyde + H(2)O <=> formate + 2-oxopent-4-enoate; Function: the phnD enzyme of Pseudomonas sp. is required for conversion of 2-hydroxymuconic semialdehyde,which is produced from catechol by the PhnE catechol 2,3-dioxygenase, to 2-hydroxypent-2,4-dienoate (EC 3. 7. 1. 9).; Similarity: the ORF shows local similarity to 2-hydroxymuconate-semialdehyde hydrolases of different species.; Similarity: the ORF shows local similarity to phnD of Pseudomonas sp. : the alignment comprises only amino acids 99-211 of the ORF.; Title: similarity to 2-hydroxymuconate-semialdehyde hydrolase phnD - Pseudomonas sp.; See PMID 9125165; uncharacterized protein 2093430 4982200 An07g09320 Aspergillus niger uncharacterized protein XP_001392006.1 2092152 R 5061 CDS An07g09325 84591522 join(2094560..2094694,2094749..2094943) IV 1 NT_166523.1 Remark: the matching EST sequence covers only upstream sequences of the cbhA gene from A. niger.; Title: strong similarity to EST upstream of cbhA -Aspergillus niger; uncharacterized protein 2094943 84591522 An07g09325 Aspergillus niger uncharacterized protein XP_059601083.1 2094560 D 5061 CDS An07g09330 4982202 join(2095750..2095965,2096015..2096401,2096453..2096654,2096711..2097264) IV 1 NT_166523.1 Catalytic activity: hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.; Gene-ID: cbhA; Induction: transcription of cbhA of A. niger is induced by D-xylose but not by sophorose and, in addition,requires the xylanolytic transcriptional activator XlnR.; Mapping: cbhA from A. niger is mapped to chromosome IV; see list from DSM, EMBL AF156268.; Pathway: cbhA of A. niger is involved in starch and sucrose metabolism.; Remark: the ORF is nearly identical to patent cbhB WO9906574-A1 in PATENTPROT:AAY00864, but differs in amino acids A86T, V170A and E359D.; Remark: the ORF overlaps with the sequence in EMBL:E32834, with sequence 5 from patent EP0897667 in EMBL:AX000304, with sequence 5 from patent WO9906574 in EMBL:AX000154, with cbhA of A. niger in EMBL:AF156268,with cbhA of A. niger in PATENTDNA:AAX21510, and with cbhA of A. niger in PATENTDNA:AAX22094.; See PMID 10508057; 1,4-beta-D-glucan cellobiohydrolase A precursor cbhA-Aspergillus niger 2097264 cbhA 4982202 cbhA Aspergillus niger 1,4-beta-D-glucan cellobiohydrolase A precursor cbhA-Aspergillus niger XP_001392008.3 2095750 D 5061 CDS An07g09340 4982203 join(2097758..2098116,2098190..2099108) IV 1 NT_166523.1 Remark: the ORF overlaps with the 5' end of the cellobiohydrolase (cbhA) sequence derived from A. niger in EMBL:AF156268. The cbhA gene lies in the adjacent contig.; Similarity: the ORF shows local weak similarity to striatin of R. norvegicus and H. sapiens over a stretch of 80 amino acids; this stretch encompasses WD repeats in the ORF and in the striatin sequence, thus the weak similarity between ORF and striatin is presumably unspecific; striatin is a calmodulin-binding protein, belonging to the WD-repeat family.; Title: similarity to hypothetical protein YPR169w -Saccharomyces cerevisiae; uncharacterized protein 2099108 4982203 An07g09340 Aspergillus niger uncharacterized protein XP_001392009.1 2097758 D 5061 CDS An07g09350 4982204 join(2099559..2100194,2100276..2100638) IV 1 NT_166523.1 Similarity: the ORF shows also (weak) local similarity to WW-domain containing oxidoreductases of H. sapiens and M. musculus.; Title: strong similarity to hypothetical protein Rv0303 - Mycobacterium tuberculosis; uncharacterized protein 2100638 4982204 An07g09350 Aspergillus niger uncharacterized protein XP_059601084.1 2099559 D 5061 CDS An07g09360 4982205 join(2101077..2101602,2101676..2102223) IV 1 NT_166523.1 Catalytic activity: 3-oxoadipate + NAD(P)(+) <=> 2-maleylacetate + NAD(P)H.; Function: MacA of R. opacus plays a major role in the degradation of chloroaromatic compounds.; Pathway: MacA of R. opacus is involved in 3-chlorocatechol degradation: this pathway is important for biodegradation of toxic aromatic compounds in the environment.; Remark: MacA of R. opacus converts 2-chloromaleylacetate, an intermediate in the degradation of dichloroaromatic compounds, to maleylacetate.; Remark: maleylacetate reductases allow bacteria to grow on chlorine containing substrates.; Remark: maleylacetate reductases play a major role in the degradation of chloroaromatic compounds by channelling maleylacetate and some chlorinated derivatives into the 3-oxoadipate pathway.; Similarity: MacA of R. opacus belongs to the iron-containing alcohol dehydrogenase family.; Title: strong similarity to maleylacetate reductase MacA - Rhodococcus opacus; See PMID 9657989; uncharacterized protein 2102223 4982205 An07g09360 Aspergillus niger uncharacterized protein XP_001392011.1 2101077 D 5061 CDS An07g09370 4982206 join(2102592..2102820,2102914..2104301) IV 1 NT_166523.1 Phenotype: disruption of the DPH2 gene of S. cerevisieae leads to a viable phenotype.; Remark: DPH2 of S. cerevisiae confers resistance to diphteriae toxin.; Remark: the DPH2 gene of S. cerevisiae is also called YKL191W.; Remark: the DPH2 gene of S. cerevisiae was isolated by complementation of a diphthamide mutant.; Title: strong similarity to diphthamide synthesis protein Dph2 - Saccharomyces cerevisiae; See PMID 8406038; uncharacterized protein 2104301 4982206 An07g09370 Aspergillus niger uncharacterized protein XP_059601085.1 2102592 D 5061 CDS An07g09380 4982207 2105156..2107759 IV 1 NT_166523.1 hypothetical protein 2107759 4982207 An07g09380 Aspergillus niger hypothetical protein XP_001392013.1 2105156 D 5061 CDS An07g09390 4982208 join(2108255..2108494,2108559..2108885) IV 1 NT_166523.1 Complex: NudF of A. nidulans and LIS1 of mammals fisically interact with NudC, raising the possibility that a common molecular mechanism underlies both the defect of neural development observed in humans and the interphase nuclear movement defect observed in the fungus.; Function: a temperature-sensitive mutation in the nudC gene of A. nidulans specifically prevents the microtubule-based movement of nuclei in this organism at the restrictive temperature.; Phenotype: nudC of A. nidulans has gained a lot of interest in the scientific community due to the involvement of its mammalian homologue in the neurologic syndrome lissencephaly, characterized by abnormal development of the brain cortex.; Remark: lissencephaly in humans is caused by mutations in the LIS1 gene and, at the cellular level, is due to defects in neuronal fate specification in the ventricular zone and of following correct migration; LIS1 is the homologue of the A. nidulans NudF gene.; Title: strong similarity to nuclear movement protein nudC - Aspergillus nidulans; See PMID 9601647; See PMID 9861667; See PMID 2199460; See PMID 7612965; uncharacterized protein 2108885 4982208 An07g09390 Aspergillus niger uncharacterized protein XP_001392014.3 2108255 D 5061 CDS An07g09400 4982209 2109841..2110362 IV 1 NT_166523.1 Remark: UPC2 of S. cerevisiae is also called YDR213W or MOX4.; Similarity: UPC2 of S. cerevisiae is a zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; the predicted protein does not contain such a domain.; Title: weak similarity to transcription activator Upc2 - Saccharomyces cerevisiae; See PMID 9696767; uncharacterized protein 2110362 4982209 An07g09400 Aspergillus niger uncharacterized protein XP_001392015.3 2109841 D 5061 CDS An07g09410 4982210 <2111043..2112980 IV 1 NT_166523.1 Function: pro1 of S. macrospora encodes a C6 zinc finger transcription factor required for fruiting body development.; Remark: The ORF is N-terminally truncated due to the contig border.; Similarity: more than 200 N-terminal (and in respect to the ORF 100 C-terminal) amino acids are excluded from the alignment between the ORF and pro1 of S. macrospora; This is partly caused by the N-terminal truncation of the ORF due to the contig border. The zinc finger is not found in the ORF sequence.; Title: strong similarity to fruiting body development transcription factor pro1 - Sordaria macrospora [truncated ORF]; See PMID 10224253; uncharacterized protein 2112980 4982210 An07g09410 Aspergillus niger uncharacterized protein XP_001392016.3 2111043 D 5061 CDS An07g09420 84591523 complement(join(2113534..2113587,2113652..2113714,2113873..2113950,2114047..2114062,2114319..2114371)) IV 1 NT_166523.1 Remark: the ORF's exon/intron structure is unusual for A. niger and the ORF is short in length (87 amino acids).; Title: questionable ORF; uncharacterized protein 2114371 84591523 An07g09420 Aspergillus niger uncharacterized protein XP_059601086.1 2113534 R 5061 CDS An07g09430 4982212 complement(join(2115238..2116104,2116186..2116260,2116325..2116342,2116729..2116896)) IV 1 NT_166523.1 Function: prtS of S. thermophilus is a serine proteinase highly activated by Ca(2+) ions.; Remark: prtS of S. thermophilus is a member of the subtilase family.; Similarity: the ORF shows local weak similarity to prtS of S. thermophilus: the ORF has a length of 306 amino acids and prtS has a length of 1585 amino acids, however,less than 100 amino acids are included in the alignment; furthermore the aligned sequence is proline-rich.; Title: weak similarity to cell envelope proteinase prtS - Streptococcus thermophilus; See PMID 11055922; uncharacterized protein 2116896 4982212 An07g09430 Aspergillus niger uncharacterized protein XP_001392018.3 2115238 R 5061 CDS An07g09440 84591524 complement(join(2118317..2118455,2118581..2118651,2118672..2118727,2118798..2118880,2119002..2119042,2119124..2119216,2119307..2119476,2119545..2119612,2119690..2119772)) IV 1 NT_166523.1 Remark: the ORF overlaps with 5' and 3' sequence of the Aspergillus awamori Vader transposon Tan1 in EMBL:AA37228.; Remark: the ORF overlaps with sequences from patent WO9808960-A1 and WO9629414-A1 encoding the A. niger Vader transposable element Tan1.; Remark: the ORF overlaps with the UTR (untranslated region) of the neighbouring transposon Tan1.; Remark: the ORF's exon/intron structure is unusual for A. niger.; hypothetical protein 2119772 84591524 An07g09440 Aspergillus niger hypothetical protein XP_059601087.1 2118317 R 5061 CDS An07g09460 4982214 complement(2120271..2121938) IV 1 NT_166523.1 Gene-ID: Tan1; Remark: organization of Tan1: IR-ORF-IR-IR-Vader-IR.; Remark: the ORF is identical or nearly identical to WO9808960-A1 in PATENTPROT:AAW58866, WO9629414-A1 in PATENTPROT:AAW04877, and WO9808960-A1 in PATENTPROT:AAW58865.; Remark: the Tan1 element of A. niger encodes a putative transposase.; Similarity: the ORF overlaps with nucleic acid entries PATENTDNA:AAV11500, PATENTDNA:AAV11494,PATENTDNA:AAT38935, and PATENTDNA:AAF11280 in the patent database.; See PMID 9003286; transposase Tan1-Aspergillus niger 2121938 Tan1 4982214 Tan1 Aspergillus niger transposase Tan1-Aspergillus niger XP_059601088.1 2120271 R 5061 CDS An07g09470 4982215 complement(join(2123522..2124686,2124739..2125640)) IV 1 NT_166523.1 Similarity: the ORF and the hypothetical protein of A. thaliana have roughly the same length; however, less than half of the amino acid sequence of the ORF is included in the alignment.; Title: strong similarity to hypothetical retroelement pol polyprotein - Arabidopsis thaliana; uncharacterized protein 2125640 4982215 An07g09470 Aspergillus niger uncharacterized protein XP_001392021.3 2123522 R 5061 CDS An07g09480 84591525 complement(join(2125717..2126405,2126468..2127121,2127431..2127613,2128014..2128029,2128120..2128122)) IV 1 NT_166523.1 Remark: chapsyn-110 of R. norvegicus is a member of the PSD-95 family of proteins.; Remark: chapsyn-110 of R. norvegicus shows heteromultimerization and NMDA receptor-clustering activity.; Similarity: the ORF shows also local similarity to STE5 of S. cerevisiae.; Similarity: the ORF shows local similarity to chapsyn-110: about 200 amino acids of the 514 amino acid ORF and of the 830 amino acid chapsyn-110 are included in the alignment.; Title: weak similarity to channel associated protein of synapse-110 chapsyn-110 - Rattus norvegicus; See PMID 8755482; uncharacterized protein 2128122 84591525 An07g09480 Aspergillus niger uncharacterized protein XP_059601089.1 2125717 R 5061 CDS An07g09490 84591526 complement(join(2128721..2128930,2129023..2129246,2129325..2129823,2129954..2130065,2130213..2130309,2130401..2130457,2130628..2130712,2130803..2130843,2131223..2131291,2131418..2131534,2131613..2131671,2131760..2131806,2131898..2131933,2132007..2132151,2132419..2132597)) IV 1 NT_166523.1 Remark: the ORF's exon/intron structure is unusual for A. niger.; hypothetical protein 2132597 84591526 An07g09490 Aspergillus niger hypothetical protein XP_059601090.1 2128721 R 5061 CDS An07g09500 84591527 complement(join(2133352..2133437,2133484..2133592,2133679..2133706,2133785..2133968,2134023..2134101)) IV 1 NT_166523.1 hypothetical protein 2134101 84591527 An07g09500 Aspergillus niger hypothetical protein XP_059601091.1 2133352 R 5061 CDS An07g09510 84591528 join(2134848..2134851,2134915..2135075,2135273..2135356) IV 1 NT_166523.1 Remark: unusual intron/exon structure for A. niger and short length (82 amino acids).; Title: questionable ORF; uncharacterized protein 2135356 84591528 An07g09510 Aspergillus niger uncharacterized protein XP_059601092.1 2134848 D 5061 CDS An07g09520 84591529 complement(join(2136198..2136328,2136500..2136538,2136651..2136725,2136802..2136994)) IV 1 NT_166523.1 Remark: the ORF's exon/intron structure is unusual for A. niger.; hypothetical protein 2136994 84591529 An07g09520 Aspergillus niger hypothetical protein XP_059601093.1 2136198 R 5061 CDS An07g09530 4982221 join(2137582..2137701,2137780..2137913,2137984..2138438,2138501..2139006) IV 1 NT_166523.1 Catalytic activity: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2.; Complex: PDA1 of S. cerevisiae is a component of the multienzyme pyruvate dehydrogenase complex: this complex contains next to E1 also E2 (dihydrolipoamide acetyltransferase) and E3 (lipoamide dehydrogenase); the complex catalyzes the conversion of pyruvate to e. g. acetyl-CoA.; Pathway: PDA1 of S. cerevisiae takes part in the pyruvate metabolism, glycolysis and val/leu/ile biosynthesis.; Phenotype: the null mutant of PDA1 of S. cerevisiae is viable, but pyruvate dehydrogenase activity is lost and the mutant exhibits reduced growth on glucose and increased formation of petites.; Remark: PDA1 of S. cerevisiae is also called YER178w and PDHE1-A.; Similarity: the ORF shows strong similarity to PDA1 of S. cerevisiae, however, the N-terminal amino acids encoding the mitochondrial localization signal, are not included in the alignment.; Title: strong similarity to alpha subunit E1 of the pyruvate dehydrogenase complex Pda1 - Saccharomyces cerevisiae; See PMID 1330555; See PMID 2684159; uncharacterized protein 2139006 4982221 An07g09530 Aspergillus niger uncharacterized protein XP_001392027.1 2137582 D 5061 CDS An07g09540 4982222 complement(join(2139944..2141699,2141774..2142035,2142109..2142280)) IV 1 NT_166523.1 Function: Piccolo of R. norvegicus is a component of the presynaptic cytoskeletal matrix (PCM) assembled at the active zone of neurotransmitter release.; Similarity: the ORF shows local similarity to Piccolo of R. norvegicus: only one fourth of the ORF sequence and 1/25 of the Piccolo sequence is included in the alignment; evenmore, the aligned sequence is alanine,proline and glutamine rich.; Title: weak similarity to multidomain presynaptic cytomatrix protein Piccolo - Rattus norvegicus; See PMID 8900486; See PMID 11182086; uncharacterized protein 2142280 4982222 An07g09540 Aspergillus niger uncharacterized protein XP_059601094.1 2139944 R 5061 CDS An07g09550 4982223 complement(join(2142360..2143247,2143325..2143488,2143576..2143798,2143881..2143916)) IV 1 NT_166523.1 Function: NAM9 of S. cerevisiae encodes for a mitochondrial ribosomal protein.; Phenotype: the null mutant of NAM9 of S. cerevisiae is viable but is respiration-deficient and loses mitochondrial DNA integrity.; Remark: NAM9 of S. cerevisiae is also called JTD486,N1211, N1840, and YNL137c.; Title: strong similarity to mitochondrial ribosomal protein Nam9 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9360714; See PMID 10982839; See PMID 1729612; See PMID 7557422; mitochondrial 37S ribosomal protein uS4m 2143916 4982223 An07g09550 Aspergillus niger mitochondrial 37S ribosomal protein uS4m XP_059601095.1 2142360 R 5061 CDS An07g09560 4982224 complement(join(2145955..2147772,2147827..2148360)) IV 1 NT_166523.1 Function: uvsD of A. nidulans controlls mitotic intragenic recombination and recovery from UV damage.; Remark: uvsD of A. nidulans also causes a rereplication phenotype.; Title: strong similarity to cell cycle check point protein uvsD - Aspergillus nidulans; See PMID 10564263; See PMID 4945003; See PMID 4945004; uncharacterized protein 2148360 4982224 An07g09560 Aspergillus niger uncharacterized protein XP_001392030.1 2145955 R 5061 CDS An07g09570 4982225 join(2149018..2149176,2149254..2149626,2149687..2150480,2150541..2150576) IV 1 NT_166523.1 Catalytic activity: CTP + phosphatidate = pyrophosphate + CDP-diacylglycerol.; Function: CDS1 of S. cerevisiae synthesizes CDP-diacylglycerol, and is thus involved in cell growth.; Pathway: CDS1 of S. cerevisiae takes part in the phospholipide biosynthesis.; Phenotype: null mutants of CDS1 of S. cerevisiae were incapable of spore germination or vegetative growth.; Remark: CDS1 of S. cerevisiae belongs to the CDS family.; Remark: CDS1 of S. cerevisiae is also called CDG1,and YBR029c.; Title: strong similarity to phosphatidate cytidylyltransferase Cds1 - Saccharomyces cerevisiae; See PMID 8557688; See PMID 8910557; uncharacterized protein 2150576 4982225 An07g09570 Aspergillus niger uncharacterized protein XP_001392031.1 2149018 D 5061 CDS An07g09580 4982226 complement(join(2151981..2152366,2152422..2152749,2152801..2152929,2152990..2153071,2153137..2153354)) IV 1 NT_166523.1 Complex: cyclin K of H. sapiens interacts with the catalytic subunit of the transcription elongation factor P-TEFb, CDK9, in vivo.; Function: cyclin K of H. sapiens functions as a regulatory subunit of CDK9, a carboxy-terminal domain kinase acting on the largest subunit of RNA polymerase II.; Function: cyclin K of H. sapiens is a modulator of transcription activity.; Function: cyclin K of H. sapiens is able to complement G1 cyclin deficiency in S. cerevisiae.; Title: similarity to cyclin K CPR4 - Homo sapiens; See PMID 9632813; See PMID 10574912; uncharacterized protein 2153354 4982226 An07g09580 Aspergillus niger uncharacterized protein XP_001392032.1 2151981 R 5061 CDS An07g09590 4982227 complement(join(2153921..2153957,2154088..2154736,2154800..2154804,2154872..2154984)) IV 1 NT_166523.1 Function: GST of patent US5962229-A is involved in the detoxification of herbicides and other xenobiotics.; Remark: shows homology to the protein from the patent database entry PATENTPROT:AAY40570.; Title: strong similarity to glutathione S-transferase GST from patent US5962229-A - Zea mays; See PMID 11080288; uncharacterized protein 2154984 4982227 An07g09590 Aspergillus niger uncharacterized protein XP_001392033.3 2153921 R 5061 CDS An07g09600 4982228 complement(2155456..2156400) IV 1 NT_166523.1 Function: FN3K of H. sapiens phosphorylates fructosamine substrates, such as fructoselysine,fructoseglycine or glycated lysozyme, at the third carbon hydroxyl of the fructose moiety.; Function: the physiological role of FN3K of H. sapiens may be to initiate a process leading to the deglycation of fructoselysine and of glycated proteins.; Title: strong similarity to fructosamine-3-kinase FN3K - Homo sapiens; See PMID 1101644; uncharacterized protein 2156400 4982228 An07g09600 Aspergillus niger uncharacterized protein XP_001392034.1 2155456 R 5061 CDS An07g09610 4982229 complement(join(2156889..2157887,2157933..2159638,2159717..2160017)) IV 1 NT_166523.1 Similarity: contains a putative leucine zipper and an armadillo tandem repeat-like domain (Pfam: PF00514).; Title: strong similarity to hypothetical protein B24H17.130 - Neurospora crassa; uncharacterized protein 2160017 4982229 An07g09610 Aspergillus niger uncharacterized protein XP_059601096.1 2156889 R 5061 CDS An07g09620 84591530 complement(join(2160553..2160794,2160893..2161095,2161243..2161553)) IV 1 NT_166523.1 hypothetical protein 2161553 84591530 An07g09620 Aspergillus niger hypothetical protein XP_059601097.1 2160553 R 5061 CDS An07g09630 4982231 join(2161991..2162614,2162643..2163224) IV 1 NT_166523.1 Function: PREG of N. crassa regulates the activity of NUC-1, a transcriptional activator of phosphorus aquisition enzymes.; Similarity: belongs to the Pho80 family of cyclin-like proteins, to which particularly the C-terminal part shows strong homology.; Title: strong similarity to phosphorus acquisition transcriptional activator NUC-1 negative regulator PREG -Neurospora crassa; See PMID 8436269; uncharacterized protein 2163224 4982231 An07g09630 Aspergillus niger uncharacterized protein XP_059601098.1 2161991 D 5061 CDS An07g09640 84591531 join(2163322..2163384,2163610..2163722,2163814..2163928) IV 1 NT_166523.1 hypothetical protein 2163928 84591531 An07g09640 Aspergillus niger hypothetical protein XP_059601099.1 2163322 D 5061 CDS An07g09650 4982233 complement(join(<2164429..2164571,2164638..2164971,2165024..2165120,2165174..2165261,2165315..2165411,2165522..2165557,2165635..2165664)) IV 1 NT_166523.1 Function: Chs7p of S. cerevisiae is involved in chitin synthase III (CSIII) export from the ER and consequently, in the regulation of CSIII activity.; Localization: Chs7p of S. cerevisiae is an integral membrane protein located in the ER.; Phenotype: in chs7 mutants of S. cerevisiae chitin synthase III (CSIII) is retained in the ER, leading to a severe defect in CSIII activity and consequently, to a reduced rate of chitin synthesis.; Remark: the ORF is C-terminally truncated due to end of contig.; Remark: the systematic gene name of CHS7 of S. cerevisiae is YHR142w.; Title: similarity to chitin synthase III like Chs7 -Saccharomyces cerevisiae [truncated ORF]; See PMID 10366589; uncharacterized protein 2165664 4982233 An07g09650 Aspergillus niger uncharacterized protein XP_059601100.1 2164429 R 5061 CDS An07g09660 84591532 join(2165790..2165849,2165958..2166134,2166366..2166557) IV 1 NT_166523.1 hypothetical protein 2166557 84591532 An07g09660 Aspergillus niger hypothetical protein XP_059601101.1 2165790 D 5061 CDS An07g09670 84591533 complement(join(2166570..2166786,2166869..2166923,2167015..2167117,2167184..2167228)) IV 1 NT_166523.1 hypothetical protein 2167228 84591533 An07g09670 Aspergillus niger hypothetical protein XP_059601102.1 2166570 R 5061 CDS An07g09680 4982236 complement(join(2167860..2168014,2168086..2168197,2168300..2168551,2168641..2168792,2168882..2168965,2169094..2169154)) IV 1 NT_166523.1 Catalytic activity: 4-carboxymethylenbut-2-en-4-olide + H2O = 4-oxo-2-endioate (maleylacetate).; Function: EC 3. 1. 1. 45 catalyzed aromate degradation leads to maleylacetate, which is subsequently metabolized to TCA cycle substrates.; Function: EC 3. 1. 1. 45 is involved in the degradation of halogenated aromates, eg dichlorobenzene.; Similarity: belongs to the family of dienelactone hydrolases.; Title: strong similarity to hypothetical carboxymethylenbutenolide hydrolase YDL086w - Saccharomyces cerevisiae; uncharacterized protein 2169154 4982236 An07g09680 Aspergillus niger uncharacterized protein XP_001392042.1 2167860 R 5061 CDS An07g09690 4982237 complement(join(2169881..2169892,2169949..2170166,2170230..2170561,2170615..2171634,2171836..2171873)) IV 1 NT_166523.1 Pathway: STS1 of S. pombe is involved in ergosterol biosynthesis.; Similarity: belongs to the ERG4/ERG24 family.; Title: strong similarity to sterol C-24(28) reductase sts1p - Schizosaccharomyces pombe; See PMID 8125337; uncharacterized protein 2171873 4982237 An07g09690 Aspergillus niger uncharacterized protein XP_001392043.1 2169881 R 5061 CDS An07g09700 4982238 join(2172913..2173182,2173428..2174343,2174566..2175443) IV 1 NT_166523.1 Similarity: contains a RING-type (C3HC4) zinc finger domain typically associated with various transcription regulators.; Title: strong similarity to hypothetical RING zinc finger protein SPBP8B7.23 - Schizosaccharomyces pombe; uncharacterized protein 2175443 4982238 An07g09700 Aspergillus niger uncharacterized protein XP_059601103.1 2172913 D 5061 CDS An07g09710 4982239 complement(join(2176475..2176630,2176684..2176872,2176924..2181228)) IV 1 NT_166523.1 Title: strong similarity to hypothetical conserved protein B1D4.270 - Neurospora crassa; uncharacterized protein 2181228 4982239 An07g09710 Aspergillus niger uncharacterized protein XP_001392045.1 2176475 R 5061 CDS An07g09720 4982240 join(2181961..2181977,2182056..>2182515) IV 1 NT_166523.1 Remark: the ORF is C-terminally truncated due to end of contig.; Title: similarity to hypothetical protein SPAC652.01 - Schizosaccharomyces pombe [truncated ORF]; uncharacterized protein 2182515 4982240 An07g09720 Aspergillus niger uncharacterized protein XP_001392046.3 2181961 D 5061 CDS An07g09730 4982241 join(2183053..2183550,2183606..2184343,2184400..2184506,2184596..2184758,2184829..2185887) IV 1 NT_166523.1 Function: the S. cerevisiae homolog Ubp3p is a ubiquitin-specific protease.; Remark: Ubp3p of S. cerevisiae is controlling the activity or assembly of the SIR protein complex, which is involved in silencing of transcription at the silent mating type loci and at the yeast telomeres.; Similarity: belongs to family 2 of ubiquitin carboxyl-terminal hydrolases.; Title: strong similarity to ubiquitin specific protease Ubp3 - Saccharomyces cerevisiae; uncharacterized protein 2185887 4982241 An07g09730 Aspergillus niger uncharacterized protein XP_001392047.1 2183053 D 5061 CDS An07g09740 4982242 complement(join(2187540..2187935,2188010..2188418,2188467..2188549,2188600..2189273,2189374..2189491)) IV 1 NT_166523.1 Function: ZrSOD2-22 of Z. rouxii CBS732 confers tolerance to toxic concentrations of Na(+) and Li(+) cations.; Function: ZrSOD2-22 of Z. rouxii CBS732 is a Na(+) efflux pump driven by the transmembrane H(+) gradient.; Title: strong similarity to Na(+)/H(+) antiporter ZrSOD2-22 - Zygosaccharomyces rouxii; See PMID 11403849; uncharacterized protein 2189491 4982242 An07g09740 Aspergillus niger uncharacterized protein XP_001392048.1 2187540 R 5061 CDS An07g09750 4982243 complement(join(2190453..2190888,2190994..2191579,2191638..2191848)) IV 1 NT_166523.1 Catalytic activity: RNase H1 of M. musculus cleaves RNA-DNA hybrids at the RNA:DNA junction generating a 3'-hydroxyl-terminated oligoribonucleotide and a 5'-monophosphate-terminated polydeoxyribonucleotide.; Function: RNase H1 of M. musculus binds to dsRNA and RNA-DNA hybrids.; Function: RNase H1 of M. musculus degrades specifically RNA of RNA-DNA hybrids.; Function: a role of RNase H1 in the removal of RNA primers during lagging-strand DNA biosynthesis is proposed.; Title: strong similarity to ribonuclease (RNase) H1 Rnh1 - Mus musculus; See PMID 9799596; See PMID 10567561; uncharacterized protein 2191848 4982243 An07g09750 Aspergillus niger uncharacterized protein XP_001392049.1 2190453 R 5061 CDS An07g09760 4982244 join(2195063..2195156,2195216..2195649,2195720..2195780,2195907..2196637,2196689..2197091,2197165..2197655) IV 1 NT_166523.1 Catalytic activity: bgln of C. molischiana catalizes the hydrolysis of terminal non-reducing beta-D-glucose residues with release of beta-D-glucose.; Function: bgln of C. molischiana is mainly involved in the degradation of various aromatic beta-glycosides, eg anthocyanin.; Title: strong similarity to beta-glucosidase bgln -Candida molischiana; cell wall; See PMID 10554245; uncharacterized protein 2197655 4982244 An07g09760 Aspergillus niger uncharacterized protein XP_059601104.1 2195063 D 5061 CDS An07g09770 4982245 complement(2198138..2199619) IV 1 NT_166523.1 Title: similarity to hypothetical protein AAO31979.1 - Fusarium sporotrichioides; uncharacterized protein 2199619 4982245 An07g09770 Aspergillus niger uncharacterized protein XP_001392051.1 2198138 R 5061 CDS An07g09780 4982246 join(2200488..2200703,2200773..2201287,2201344..2201740) IV 1 NT_166523.1 hypothetical protein 2201740 4982246 An07g09780 Aspergillus niger hypothetical protein XP_001392052.1 2200488 D 5061 CDS An07g09782 84591534 2201989..2202540 IV 1 NT_166523.1 hypothetical protein 2202540 84591534 An07g09782 Aspergillus niger hypothetical protein XP_059601105.1 2201989 D 5061 CDS An07g09790 4982248 join(2203017..2203219,2203283..2203849,2204008..2204085,2204166..2204362,2204560..2204609) IV 1 NT_166523.1 Title: similarity to hypothetical protein YKL051w -Saccharomyces cerevisiae; uncharacterized protein 2204609 4982248 An07g09790 Aspergillus niger uncharacterized protein XP_059601106.1 2203017 D 5061 CDS An07g09800 4982249 complement(join(2204854..2204988,2205049..2207298)) IV 1 NT_166523.1 Function: VTC3 of S. cerevisiae is involved in the phosphate metabolism and its transcription is regulated by PHO system.; Remark: VTC3 of S. cerevisiae is also called LPB12C,YPL019C or PHM2.; Similarity: the ORf shows strong similarity to several putative polyphosphate synthetases.; Title: strong similarity to hypothetical polyphosphate synthase Vtc3 - Saccharomyces cerevisiae; See PMID 11102525; uncharacterized protein 2207298 4982249 An07g09800 Aspergillus niger uncharacterized protein XP_001392055.1 2204854 R 5061 CDS An07g09810 4982250 join(2207994..2208457,2208526..2209378) IV 1 NT_166523.1 Remark: SPAC14C4. 10c of S. pombe is believed to be a member of the family of nudix hydrolases, and to function in hydrolysing nucleoside diphosphate derivatives.; Title: strong similarity to hypothetical protein SPAC14C4.10c - Schizosaccharomyces pombe; uncharacterized protein 2209378 4982250 An07g09810 Aspergillus niger uncharacterized protein XP_001392056.1 2207994 D 5061 CDS An07g09820 4982251 join(2209494..2209577,2209669..2209890,2209970..2210001,2210081..2210162,2210209..2210235) IV 1 NT_166523.1 Title: similarity to hypothetical protein CAD21149.1 - Neurospora crassa; uncharacterized protein 2210235 4982251 An07g09820 Aspergillus niger uncharacterized protein XP_059601107.1 2209494 D 5061 CDS An07g09830 4982252 join(2211016..2211170,2211264..2211291,2211351..2211864,2211929..2212580,2212654..2212858) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein encoded by B19C19.110 - Neurospora crassa; uncharacterized protein 2212858 4982252 An07g09830 Aspergillus niger uncharacterized protein XP_059601108.1 2211016 D 5061 CDS An07g09840 4982253 join(2213681..2213749,2213809..2215080) IV 1 NT_166523.1 Function: tetA of E. coli is an efflux transporter,which confers resistance to tetracycline.; Similarity: the ORF shows strong similarity to several membrane transporters from different species,especially to tetracycline resistance proteins.; Title: similarity to tetracyclin resistance protein tetA - Escherichia coli; uncharacterized protein 2215080 4982253 An07g09840 Aspergillus niger uncharacterized protein XP_001392059.1 2213681 D 5061 CDS An07g09850 4982254 complement(join(2215731..2216536,2216608..2216905)) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein B9J10.230 - Neurospora crassa; uncharacterized protein 2216905 4982254 An07g09850 Aspergillus niger uncharacterized protein XP_001392060.1 2215731 R 5061 CDS An07g09860 4982255 complement(join(2217251..2217913,2217970..2218268,2218325..2218456,2218510..2218644,2218696..2219639,2219714..2219850)) IV 1 NT_166523.1 Function: sepB of A. nidulans is involved in chromosome segregation and the initiation of cytokinesis.; Remark: the predicted A. niger ORF is 55 amino acid longer at its C-terminus than sepB of A. nidulans.; Title: strong similarity to chromosome segregation protein sepB - Aspergillus nidulans; uncharacterized protein 2219850 4982255 An07g09860 Aspergillus niger uncharacterized protein XP_059601109.1 2217251 R 5061 CDS An07g09870 4982256 complement(join(2220487..2221683,2221747..2221958,2222044..2222461)) IV 1 NT_166523.1 Catalytic activity: dihydroxy-acid dehydratases convert 2,3-dihydroxy-3-methylbutanoate <=> 3-methyl-2-oxobutanoate + H(2)O.; Function: dihydroxy-acid dehydratases are involvedin the biosynthesis of amino acids from the pyruvate family.; Remark: ILV3 of S. cerevisiae is also called YJR016C or J1450.; Similarity: the ORF shows strong similarity to dihydroxy-acid dehydratases from several bacteria.; Title: strong similarity to dihydroxy-acid dehydratase Ilv3 - Saccharomyces cerevisiae; See PMID 8299945; uncharacterized protein 2222461 4982256 An07g09870 Aspergillus niger uncharacterized protein XP_001392062.1 2220487 R 5061 CDS An07g09880 4982257 complement(join(2222923..2224375,2224429..2224691)) IV 1 NT_166523.1 Catalytic activity: CYP7 of O. cuniculus c catalyses cholesterol + NADPH + O(2) <=> 7-alpha-hydroxycholesterol + NADP(+) + H(2)O.; Function: cholesterol 7alpha-monooxygenase is a key enzyme in a series of metabolic changes for the production of bile acids from cholesterol.; Title: similarity to cholesterol 7alpha-monooxygenase CYP7 - Oryctolagus cuniculus; uncharacterized protein 2224691 4982257 An07g09880 Aspergillus niger uncharacterized protein XP_001392063.1 2222923 R 5061 CDS An07g09890 4982258 complement(join(2225166..2225722,2225778..2227529,2227589..2227778)) IV 1 NT_166523.1 Function: RNA12 of S. cerevisiae is involved in mitochondrial genome maintenance by controlling rRNA processing.; Phenotype: RNA12-1 is a dominant temperature-sensitive (Ts) S. cerevisiae mutant which has been reported to exhibit a defect in RNA accumulation at 37 degrees C.; Phenotype: inactivation of the S. cerevisiae nuclear gene RNA12 causes an increased rate of DNA escape from mitochondria to the nucleus.; Remark: RNA12 of S. cerevisiae is also called prp12,YME2 or YMR302C.; Title: strong similarity to pre-rRNA maturation protein Rna12 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8649384; uncharacterized protein 2227778 4982258 An07g09890 Aspergillus niger uncharacterized protein XP_001392064.1 2225166 R 5061 CDS An07g09900 4982259 2228082..2228765 IV 1 NT_166523.1 Similarity: the predicted ORF is 79 amino acids longer at the N-terminus than the hypothetical protein SPAC227. 17c of S. pombe.; Title: similarity to hypothetical protein CAD70286.1 - Neurospora crassa; uncharacterized protein 2228765 4982259 An07g09900 Aspergillus niger uncharacterized protein XP_001392065.1 2228082 D 5061 CDS An07g09910 84591535 2229217..2230392 IV 1 NT_166523.1 Similarity: blastp matches are due to repetetive sequences.; hypothetical protein 2230392 84591535 An07g09910 Aspergillus niger hypothetical protein XP_059601110.1 2229217 D 5061 CDS An07g09920 4982261 complement(join(2230989..2233802,2233862..2237211,2237271..2237311,2237414..2237589)) IV 1 NT_166523.1 Similarity: the ORF shows similarity to several glutamate synthases with different cofactor-requirements,represented by EC numbers 1. 4. 7. 1, 1. 4. 1. 14 and 1. 4. 1. 13.; Title: strong similarity to NADH-dependent glutamate synthase NADH-GOGAT - Medicago sativa; See PMID 8453303; uncharacterized protein 2237589 4982261 An07g09920 Aspergillus niger uncharacterized protein XP_001392067.1 2230989 R 5061 CDS An07g09930 84591536 join(2238169..2238260,2238343..2238414,2238549..2238581,2238736..2238987,2239313..2239445) IV 1 NT_166523.1 hypothetical protein 2239445 84591536 An07g09930 Aspergillus niger hypothetical protein XP_059601111.1 2238169 D 5061 CDS An07g09940 84591537 complement(join(2240987..2241148,2241228..2241321,2241417..2241471,2241514..2241591,2241685..2241815,2241890..2242019,2242272..2242541,2242737..2242818,2242857..2242994,2243203..2243400)) IV 1 NT_166523.1 Remark: no blast match was found.; hypothetical protein 2243400 84591537 An07g09940 Aspergillus niger hypothetical protein XP_059603832.1 2240987 R 5061 CDS An07g09950 4982264 join(2244313..2244345,2244436..2245530) IV 1 NT_166523.1 hypothetical protein 2245530 4982264 An07g09950 Aspergillus niger hypothetical protein XP_001392070.1 2244313 D 5061 CDS An07g09960 4982265 complement(join(2246363..2246566,2246627..2246720,2246798..2247001,2247073..2247083)) IV 1 NT_166523.1 Function: BET1 of S. cerevisiae is involved in ER to Golgi transport and retrograde (Golgi to ER) transport of proteins.; Phenotype: overexpression of BET1 in S. cerevisiae compensates for the loss of function of the ras-like GTP-binding protein Ypt1.; Remark: of S. cerevisiae is also called SLY12,YIL004C or YIA4C.; Title: strong similarity to v-SNARE Bet1 -Saccharomyces cerevisiae; intracellular transport vesicles; See PMID 1396561; uncharacterized protein 2247083 4982265 An07g09960 Aspergillus niger uncharacterized protein XP_001392071.3 2246363 R 5061 CDS An07g09970 4982266 complement(join(2247768..2247970,2248065..2248074,2248160..2248315)) IV 1 NT_166523.1 hypothetical protein 2248315 4982266 An07g09970 Aspergillus niger hypothetical protein XP_001392072.3 2247768 R 5061 CDS An07g09980 84591538 join(2248317..2248377,2248479..2248640,2248721..2248887,2249048..2249213,2249285..2249400) IV 1 NT_166523.1 Remark: the predicted exon-intron structure of the ORF is not typical for A. niger proteins.; hypothetical protein 2249400 84591538 An07g09980 Aspergillus niger hypothetical protein XP_059603833.1 2248317 D 5061 CDS An07g09990 4982268 join(2250085..2251872,2251938..>2252061) IV 1 NT_166523.1 Function: the purified hsp70 of A. capsulata induces a cellular immune response in humans, probably due to the presence of peptide fragments/proteins copurified with the chaperone.; Function: the very conserved family of hsp70 proteins is involved in protein folding and assembling/disassembling of protein complexes in various cellular compartments.; Remark: the sequence of the predicted ORF was corrected, becauuse it contains two putative frameshifts due to possible sequencing errors at two different positions (in each case one nucleotide, probably 'G' was missing).; Similarity: the ORF overlaps with A. niger ESTs an_3500 (EMBLEST:BE759161) and an_3404 (EMBLEST:BE760676).; Title: strong similarity to heat shock protein 70 hsp70 - Ajellomyces capsulatus [putative frameshift]; putative frameshift; uncharacterized protein 2252061 4982268 An07g09990 Aspergillus niger uncharacterized protein XP_059603834.1 2250085 D 5061 CDS An07g10000 4982269 complement(join(2252354..2252451,2252573..2252687,2252837..2252960,2253208..2253230)) IV 1 NT_166523.1 Remark: the ORF has an intron-exon structure, which is not typical for A. niger ORFs and is only 119 amino acids long.; Title: questionable ORF; uncharacterized protein 2253230 4982269 An07g10000 Aspergillus niger uncharacterized protein XP_001392075.3 2252354 R 5061 CDS An07g10010 4982270 complement(join(2253872..2254207,2254280..2254457,2254515..2254762,2254834..2254875,2254962..2254999,2255064..2255151)) IV 1 NT_166523.1 Function: YHM1 of S. cerevisiae is a multicopy suppressor of the temperature-sensitive defect associated with an abf2 null mutation lacking the HMG1-like mitochondrial DNA-binding protein HM, which is required for maintenance of the yeast mitochondrial genome.; Remark: YHM1 of S. cerevisiae is also called SHM1,YDL198C or D1214.; Similarity: the ORF overlaps witg A. niger EST an_3460, database entry EMBLEST:BE759135.; Title: strong similarity to mitochondrial carrier protein Yhm1 - Saccharomyces cerevisiae; See PMID 1990290; uncharacterized protein 2255151 4982270 An07g10010 Aspergillus niger uncharacterized protein XP_001392076.1 2253872 R 5061 CDS An07g10020 4982271 complement(join(2256063..2256096,2256172..2256404,2256524..2256613)) IV 1 NT_166523.1 Function: AUT7 of S. cerevisiae is essential for an early step in autophagic and cytoplasma-to-vacuole (CVT) vesicle formation. it is also required for the attachment of these vesicles to microtubules.; Phenotype: S. cerevisiae AUT7 null mutants are viable but lack autophagocytosis and are unable to sporulate.; Remark: AUT7 of S. cerevisiae is also called APG8 or CVT5.; Remark: S. cerevisiae Aut7p interacts with the APG conguation system, a protein modification system similar to the ubiquitin conjugation pathway.; Similarity: the ORF shows also strong similarity to ganglioside expression factor 2 homologues/GABA-A receptor-associated.; Title: strong similarity to microtubule-associated protein Aut7 - Saccharomyces cerevisiae; cytoplasm; See PMID 9649430; uncharacterized protein 2256613 4982271 An07g10020 Aspergillus niger uncharacterized protein XP_001392077.1 2256063 R 5061 CDS An07g10030 84591539 join(2256829..2256938,2256993..2257137,2257231..2257295,2257433..2257655) IV 1 NT_166523.1 hypothetical protein 2257655 84591539 An07g10030 Aspergillus niger hypothetical protein XP_059603835.1 2256829 D 5061 CDS An07g10040 4982273 join(2257756..2257968,2258028..2259137) IV 1 NT_166523.1 Catalytic activity: HEM13 of S. cerevisiae catalyses coproporphyrinogen-III + O(2) <=> protoporphyrinogen-IX + 2 CO(2).; Function: HEM13 from S. cerevisiae catalyzes the sixth enzymic step in the heme biosynthetic pathway; coproporphyrinogen oxidases III are generally involved in the biosynthesis of porphyrins such as heme, chlorophyll or cobalamin.; Induction: the expression of HEM13 from S. cerevisiae is negatively regulated by heme and oxygen.; Phenotype: the loss of coproporphyrinogen oxidase activity by anaerobiosis in S. cerevisiae caused a considerable decrease of heme formation in anaerobic cells.; Title: strong similarity to coproporphyrinogen oxidase III Hem13 - Saccharomyces cerevisiae; cytoplasm; See PMID 2838478; uncharacterized protein 2259137 4982273 An07g10040 Aspergillus niger uncharacterized protein XP_001392079.1 2257756 D 5061 CDS An07g10050 4982274 complement(join(2259625..2259810,2259874..2259969,2260264..2260649,2260708..2260820,2260873..2262476)) IV 1 NT_166523.1 Function: HOOK3 of H. sapiens is required for the maturation of multivesicular bodies, which are required for diverse membrane-trafficking events.; Phenotype: overexpression of HOOK3 in human cells caused fragmentation of the Golgi complex, therefore HOOK3 is believed to participate in defining the architecture and localization of the mammalian Golgi complex.; Similarity: the similarity of the ORF to HOOK3 of H. sapiens is restricted to the N-terminal part, which includes the conserved NH(2)-terminal domain characteristic for Hook proteins that mediates attachment to microtubules, whereas the more divergent COOH-terminal domain of HOOK3,which mediates the binding to organelles, shows no significant similarity to the ORF.; Title: strong similarity to golgi-associated microtubule-binding protein HOOK3 - Homo sapiens; uncharacterized protein 2262476 4982274 An07g10050 Aspergillus niger uncharacterized protein XP_059603836.1 2259625 R 5061 CDS An07g10060 4982275 complement(join(2263188..2263293,2263347..2263356,2263439..2263463,2263530..2263661)) IV 1 NT_166523.1 Similarity: the ORF overlaps with A. niger ESTs an_2186 (EMBLEST:BE759383) and an_2334 (EMBLEST:BE759511).; Title: strong similarity to proteinase B inhibitor 2 Pbi2 - Saccharomyces cerevisiae; See PMID 2015812; uncharacterized protein 2263661 4982275 An07g10060 Aspergillus niger uncharacterized protein XP_001392081.1 2263188 R 5061 CDS An07g10070 84591540 complement(join(2263830..2263932,2263978..2264043,2264134..2264231)) IV 1 NT_166523.1 Remark: A. niger EST from patent WO200056762-A2 has the database entry number PATENTDNA:AAF11649 (SEQ ID NO:4172).; Title: strong similarity to EST SEQ ID NO:4172 from patent WO200056762-A2 - Aspergillus niger; uncharacterized protein 2264231 84591540 An07g10070 Aspergillus niger uncharacterized protein XP_059603837.1 2263830 R 5061 CDS An07g10080 4982277 join(2264945..2265112,2265226..2265681,2265742..2266475,2266536..2266731,2266786..2267154,2267213..2267263) IV 1 NT_166523.1 Function: PCF11 of S. cerevisiae directly contacts the phosphorylated carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase II.; Function: PCF11 of S. cerevisiae is one of the five subunits of pre-mRNA cleavage/polyadenylation factor IA,which is necessary for RNA 3' end processing.; Title: strong similarity to RNA processing factor Pcf11 - Saccharomyces cerevisiae; See PMID 9223284; See PMID 11149954; See PMID 11344258; uncharacterized protein 2267263 4982277 An07g10080 Aspergillus niger uncharacterized protein XP_059603838.1 2264945 D 5061 CDS An07g10090 4982278 join(2267796..2267829,2267910..2267930,2267987..2268517,2268621..2269195) IV 1 NT_166523.1 Catalytic activity: dimeric dihydrodiol dehydrogenases (= trans-1,2-dihydrobenzene-1,2-diol dehydrogenases) convert trans-1,2-dihydrobenzene-1,2-diol + NADP(+) <=> catechol + NADPH.; Function: JMO2DD of M. fuscat has additionally to its 3-deoxyglucosone reductase function an activity of NADP-dependent D-xylose dehydrogenase (EC 1. 1. 1. 179).; Remark: JMO2DD of M. fuscata is also called CMO2DD.; Title: strong similarity to dimeric dihydrodiol dehydrogenase JMO2DD - Macaca fuscata; See PMID 10477285; uncharacterized protein 2269195 4982278 An07g10090 Aspergillus niger uncharacterized protein XP_001392084.1 2267796 D 5061 CDS An07g10100 4982279 complement(join(2269602..2270010,2270074..2270228,2270299..2270351,2270449..2270608)) IV 1 NT_166523.1 Catalytic activity: adk1 of S. cerevisiae converts ATP + AMP <=> 2 ADP.; Function: adk1 of S. cerevisiae catalyzes the reversible phosphorylation of adenine monophosphate with adenosine triphosphate to form two adenosine diphosphates in the presence of magnesium, an essential reaction for many processes in living cells.; Remark: adk1 of S. cerevisiae is also called YDR226W, AKY2 or AKY1.; Title: strong similarity to adenylate kinase Adk1 -Saccharomyces cerevisiae; uncharacterized protein 2270608 4982279 An07g10100 Aspergillus niger uncharacterized protein XP_001392085.1 2269602 R 5061 CDS An07g10110 4982280 join(2271361..2271544,2271617..2271888,2271964..2272578) IV 1 NT_166523.1 Function: the regulatory particel of the 26S proteasome covers the presumed channels leading into the interior of the core particle and is required for the entry of substrates into the proteasome core.; Similarity: the ORF shows strong similarity to homologues of the rpn12 protein from different species, but also to another 26S proteasome regulatory protein, rnp8 of S. cerevisiae.; Title: strong similarity to 26S proteasome regulatory chain 12 rpn12 - Homo sapiens; See PMID 9584156; uncharacterized protein 2272578 4982280 An07g10110 Aspergillus niger uncharacterized protein XP_001392086.1 2271361 D 5061 CDS An07g10120 4982281 complement(join(2272820..2272902,2273221..2274031)) IV 1 NT_166523.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: weak similarity to hypothetical protein CAD21232.1 - Neurospora crassa; uncharacterized protein 2274031 4982281 An07g10120 Aspergillus niger uncharacterized protein XP_001392087.3 2272820 R 5061 CDS An07g10130 84591541 complement(join(2274380..2275607,2275661..2276055,2276114..2276157,2276268..2276517)) IV 1 NT_166523.1 Catalytic activity: ubiquitin-specific processing proteases catalyse ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol.; Function: DUB-1 of M. musculus is a thiol protease,that recognizes and hydrolyzes the peptide bond at the C-terminal glycine of ubiquitin and are by this involved in the processing of poly-ubiquitin precursors as well as that of ubiquinated proteins.; Function: DUB-1 of M. musculus is an enzyme of the ubiquitin system directly implicated in cytokine-regulated growth control by integrating extracellular signals with cellular growth and cell cycle progression, and in cytokine-induced cell proliferation.; Induction: DUB-1 of M. musculus is induced by interleukin (IL-3).; Remark: DUB-1 of M. musculus is also called deubiquitinating enzyme, ubiquitin carboxy-terminal hydrolase or ubiquitin thiolesterase.; Similarity: the ORF shows weak similarity to some ubiquitin-specific proteinases from different species.; Similarity: the similarity of the ORF to DUB-1 of M. musculus is locally high in the N-terminus, ending with amino acid 400 of the ORF, but importantly, the cystein at position 60 and the histidine residues at positions 298/307 of DUB-1 from M. musculus, which are probably implicated in the catalytic mechanism, are present in the predicted ORF.; Title: weak similarity to ubiquitin specific processing protease DUB1 - Mus musculus; See PMID 8622927; uncharacterized protein 2276517 84591541 An07g10130 Aspergillus niger uncharacterized protein XP_059603839.1 2274380 R 5061 CDS An07g10140 84591542 complement(join(2277681..2277806,2277899..2278016,2278397..2278441,2278768..2278862,2278936..2278995)) IV 1 NT_166523.1 Remark: the ORF has an intron-exon structure, which is not typical for A. niger ORFs and is only 147 amino acids long.; Title: questionable ORF; uncharacterized protein 2278995 84591542 An07g10140 Aspergillus niger uncharacterized protein XP_059603840.1 2277681 R 5061 CDS An07g10150 84591543 complement(join(2280694..2280866,2280972..2281244,2281379..2281448)) IV 1 NT_166523.1 Remark: the predicted ORF has an exon-intron structure, which is not typical for A. niger proteins.; hypothetical protein 2281448 84591543 An07g10150 Aspergillus niger hypothetical protein XP_059603841.1 2280694 R 5061 CDS An07g10160 84591544 join(2282185..2282322,2282653..2282769,2282934..2283035) IV 1 NT_166523.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght of only 118 amino acids.; Title: questionable ORF; uncharacterized protein 2283035 84591544 An07g10160 Aspergillus niger uncharacterized protein XP_059603842.1 2282185 D 5061 CDS An07g10170 84591545 2284167..2284496 IV 1 NT_166523.1 Remark: the ORF is questionable due its short lenght of only 109 amino acids.; Title: questionable ORF; uncharacterized protein 2284496 84591545 An07g10170 Aspergillus niger uncharacterized protein XP_059603843.1 2284167 D 5061 CDS An07g10180 84591546 complement(join(2287996..2288075,2288129..2288329,2288425..2288497)) IV 1 NT_166523.1 Remark: the ORF has an intron-exon structure, which is not typical for A. niger ORFs and is only 117 amino acids long.; Title: questionable ORF; uncharacterized protein 2288497 84591546 An07g10180 Aspergillus niger uncharacterized protein XP_059603844.1 2287996 R 5061 CDS An07g10190 4982288 join(2288662..2289140,2289210..2289612) IV 1 NT_166523.1 Remark: the expansion of CAG repeats is characteristic for the DRPLA protein of e. g. H. sapiens,which leads to the dentatorubral and pallidoluysian atrophy (DRPLA), an autosomal dominant neurodegenerative disorder.; Remark: the lenght of the predicted ORF (293 amino acids) and the high similarity to the DRPLA related protein of N. crassa, which is 538 amino acids long, suggests that the predicted A. niger homolog has an wrong stop codon; it is assumed that the right stop codon was cut due to contig border.; Title: strong similarity to hypothetical DRPLA related protein - Neurospora crassa; See PMID 8852663; uncharacterized protein 2289612 4982288 An07g10190 Aspergillus niger uncharacterized protein XP_059603845.1 2288662 D 5061 CDS An07g10200 4982289 complement(join(2289924..2290416,2290640..2290764,2290851..2290976)) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein SPAC13D6.03c - Schizosaccharomyces pombe; uncharacterized protein 2290976 4982289 An07g10200 Aspergillus niger uncharacterized protein XP_001392095.1 2289924 R 5061 CDS An07g10210 4982290 join(2291888..2292157,2292379..2292598,2292725..2292831,2292865..2293056) IV 1 NT_166523.1 Function: CKAP1 of H. sapiens binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer.; Similarity: CKAP1 of H. sapiens belongs to the ckap1/alp11 subfamily.; Title: strong similarity to tubulin folding cofactor B CKAP1 - Homo sapiens; See PMID 9265649; uncharacterized protein 2293056 4982290 An07g10210 Aspergillus niger uncharacterized protein XP_059603846.1 2291888 D 5061 CDS An07g10220 4982291 complement(join(2293425..2293639,2293723..2293971,2294025..2295230,2295295..2295455,2295585..2295649)) IV 1 NT_166523.1 Title: similarity to hypothetical neurofilament triplet H1 related protein B3E4.50 - Neurospora crassa; uncharacterized protein 2295649 4982291 An07g10220 Aspergillus niger uncharacterized protein XP_001392097.1 2293425 R 5061 CDS An07g10230 4982292 2296048..2297106 IV 1 NT_166523.1 Catalytic activity: endonucleolytic cleavage to 5'-phospho-monoester.; Function: RNase H specifically cleaves a RNA base-paired to a complementary DNA strand.; Remark: RNH35 of S. cerevisiae is also called YNL072w.; Title: strong similarity to ribonuclease HI large subunit Rnh35 - Saccharomyces cerevisiae; See PMID 9462832; uncharacterized protein 2297106 4982292 An07g10230 Aspergillus niger uncharacterized protein XP_001392098.1 2296048 D 5061 CDS An07g10240 4982293 complement(join(2297437..2297560,2297628..2298465,2298543..2298578,2298645..2298798)) IV 1 NT_166523.1 Localization: Pex16 of Y. lipolytica is a peripheral protein located at the matrix face of the peroxisomal membrane.; Phenotype: Pex16 mutants in Y. lipolytica are defective in peroxisome assembly.; Phenotype: mutation of Pex16 in humans causes a form of Zellweger syndrome, a disease due to defective import of peroxisomal matrix proteins.; Title: strong similarity to peroxisomal membrane protein peroxin-16 pex-16 - Yarrowia lipolytica; peroxisome; See PMID 9182661; See PMID 9922452; uncharacterized protein 2298798 4982293 An07g10240 Aspergillus niger uncharacterized protein XP_001392099.1 2297437 R 5061 CDS An07g10250 4982294 complement(2299203..2301674) IV 1 NT_166523.1 Function: SAE2 of S. cerevisiae is involved in meiotic recombination and chromosome metabolism.; Remark: SAE2 of S. cerevisiae is also known as COM1 or YGL175C.; Similarity: the similarity to SAE2 of S. cerevisiae is due only to a very short, but very conserved, amino acid stretch.; Title: weak similarity to protein Sae2 -Saccharomyces cerevisiae; See PMID 9215888; See PMID 11333222; uncharacterized protein 2301674 4982294 An07g10250 Aspergillus niger uncharacterized protein XP_001392100.3 2299203 R 5061 CDS An07g10260 4982295 join(2301713..2301867,2301926..2303447) IV 1 NT_166523.1 Remark: Fbxw6 from mouse seems to be part of a ubiquitin protein ligase.; Title: weak similarity to F-box-WD40 repeat protein Fbxw6 - Mus musculus; uncharacterized protein 2303447 4982295 An07g10260 Aspergillus niger uncharacterized protein XP_059603847.1 2301713 D 5061 CDS An07g10270 4982296 join(2304508..2304544,2304880..2304899,2305020..2305054,2305118..2305131,2305269..2305283,2305379..2305663,2305724..2305833) IV 1 NT_166523.1 Function: byr3 of S. pombe acts in the sexual differentiation pathway, and is required for efficient conjugation.; Function: byr3 of S. pombe is a double stranded DNA-binding protein.; Similarity: A. niger EST EMBLEST:BE758932 contains exons 6 and 7, and part of the putative 3'UTR.; Similarity: byr3 of S. pombe is similar to human CNBP and to retroviral nucleic acid binding proteins (NBP).; Similarity: the predicted protein, as well as S. pombe byr3, contains typical Zinc finger motifs called Zinc knucles; the zinc knuckle is a zinc binding motif composed of 18 residues, mainly found in the nucleocapsid protein of retroviruses, where it is required for viral genome packaging and for early infection process; it is also found in eukaryotic proteins involved in RNA or DNA binding.; Title: strong similarity to cellular nucleic acid binding protein byr3p - Schizosaccharomyces pombe; See PMID 1515675; uncharacterized protein 2305833 4982296 An07g10270 Aspergillus niger uncharacterized protein XP_001392102.1 2304508 D 5061 CDS An07g10280 4982297 complement(join(2306453..2306653,2306722..2307827,2307880..2308030,2308091..2308121,2308174..2308183,2308248..2308605)) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein B17C10.170 - Neurospora crassa; uncharacterized protein 2308605 4982297 An07g10280 Aspergillus niger uncharacterized protein XP_001392103.3 2306453 R 5061 CDS An07g10290 4982298 join(2309342..2309392,2309469..2309749,2309840..2310386) IV 1 NT_166523.1 Similarity: A. niger EST EMBLEST:BE758817 corresponds to exon 3 and part of the putative 3'UTR of the gene.; Similarity: the predicted protein shows strong similarity to many hypothetical members of the aldo/keto reductase family, which includes a number of related monomeric NADPH-dependent oxidoreductases, such as aldehyde reductase, aldose reductase, prostaglandin F synthase,xylose reductase, rho crystallin, and many others.; Title: strong similarity to MP protein sequence SEQ ID NO:860 from patent WO200100843-A2 - Corynebacterium glutamicum; See PMID 2498333; uncharacterized protein 2310386 4982298 An07g10290 Aspergillus niger uncharacterized protein XP_001392104.3 2309342 D 5061 CDS An07g10300 84591547 join(2310637..2310709,2310797..2311043,2311094..2311343) IV 1 NT_166523.1 hypothetical protein 2311343 84591547 An07g10300 Aspergillus niger hypothetical protein XP_059603848.1 2310637 D 5061 CDS An07g10310 4982300 2311551..2313980 IV 1 NT_166523.1 Title: weak similarity to PPAR gamma coactivator PGC-1 - Mus musculus; See PMID 9529258; uncharacterized protein 2313980 4982300 An07g10310 Aspergillus niger uncharacterized protein XP_001392106.1 2311551 D 5061 CDS An07g10320 4982301 complement(join(2314346..2314369,2314571..2314595,2314693..2316868,2316939..2316951)) IV 1 NT_166523.1 Title: strong similarity to hypothetical conserved protein B13I18.30 - Neurospora crassa; uncharacterized protein 2316951 4982301 An07g10320 Aspergillus niger uncharacterized protein XP_059603849.1 2314346 R 5061 CDS An07g10330 84591548 join(2317180..2317291,2317398..2317469,2317568..2317947) IV 1 NT_166523.1 hypothetical protein 2317947 84591548 An07g10330 Aspergillus niger hypothetical protein XP_059603850.1 2317180 D 5061 CDS An07g10340 4982303 join(2318065..2318133,2318194..2318973) IV 1 NT_166523.1 Gene-ID: srgD; Similarity: the C-terminal part of the predicted protein is almost identical to an A. niger partial mRNA for a secretion related GTPase; the GTPase is called SrgD, but it was not published, and is poorly characterized.; See PMID 11489135; secretion related GTPase srgD-Aspergillus niger 2318973 srgD 4982303 srgD Aspergillus niger secretion related GTPase srgD-Aspergillus niger XP_059603851.1 2318065 D 5061 CDS An07g10350 4982304 complement(join(2319439..2320082,2320152..2320911,2320967..2321519,2321590..2321720,2321799..2321936)) IV 1 NT_166523.1 Catalytic activity: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosyl-protein.; Gene-ID: pmtA; Pathway: glycosylation.; Remark: the matching sequence of pmtA from A. niger was found by a BLAST search against the new EMBL entry AAK77607.; Similarity: the predicted ORF is almost identical to A. nidulans pmtA that was recently cloned, but not yet published.; protein O-mannosyl transferase pmtA-Aspergillus niger 2321936 pmtA 4982304 pmtA Aspergillus niger protein O-mannosyl transferase pmtA-Aspergillus niger XP_001392110.1 2319439 R 5061 CDS An07g10360 84591549 join(2321965..2322065,2322149..2322185,2322300..2322318,2322427..2322575) IV 1 NT_166523.1 Remark: the ORF is classified as questionable because it partially overlaps to A. niger EST EMBLEST:BE759972, which might represent the 5'UTR of the following gene model caut. 00. tfa_40wk.; Title: questionable ORF; uncharacterized protein 2322575 84591549 An07g10360 Aspergillus niger uncharacterized protein XP_059603852.1 2321965 D 5061 CDS An07g10370 4982306 complement(join(2324174..2324565,2324625..2325337,2325397..2325547,2325612..2325937,2325992..2326069,2326128..2326186)) IV 1 NT_166523.1 Function: HGT1 of K. lactis is an high affinity glucose transporter.; Similarity: HGT1 of K. lactis belongs to the sugar transporter family.; Title: strong similarity to high-affinity glucose transporter HGT1 - Kluyveromyces lactis; plasma membrane; See PMID 8830679; uncharacterized protein 2326186 4982306 An07g10370 Aspergillus niger uncharacterized protein XP_059603853.1 2324174 R 5061 CDS An07g10380 84591550 join(2326292..2326433,2326522..2326616,2326703..2326740,2326826..2326909,2326987..2327058,2327187..2327325) IV 1 NT_166523.1 Title: questionable ORF; uncharacterized protein 2327325 84591550 An07g10380 Aspergillus niger uncharacterized protein XP_059603854.1 2326292 D 5061 CDS An07g10390 84591551 complement(2328182..2329066) IV 1 NT_166523.1 Remark: SFC1 of S. cerevisiae is also called ACR1 or YJR095W.; Title: weak similarity to succinate-fumarate transport protein Sfc1 - Saccharomyces cerevisiae; See PMID 7908717; uncharacterized protein 2329066 84591551 An07g10390 Aspergillus niger uncharacterized protein XP_059603855.1 2328182 R 5061 CDS An07g10395 4982308 complement(join(2329299..2329347,2329414..2329604)) IV 1 NT_166523.1 Title: strong similarity to hypothetical protein EAA62284.1 - Aspergillus nidulans; uncharacterized protein 2329604 4982308 An07g10395 Aspergillus niger uncharacterized protein XP_001392114.3 2329299 R 5061 CDS An07g10400 4982310 join(2330258..2330437,2330497..2330581,2330646..2330767,2330831..2330983,2331031..2332462,2332512..2333110,2333159..2333650) IV 1 NT_166523.1 Complex: CDC68 of S. cerevisiae interacts with Pob3 to form the CP complex.; Function: CDC68 of S. cerevisiae is an essential nuclear protein required for gene activation and also chromatin-mediated repression.; Remark: CDC68 of S. cerevisiae is also known as SPT16 or YGL207W.; Title: strong similarity to cell division control protein Cdc68 - Saccharomyces cerevisiae; nucleus; See PMID 7565755; See PMID 7935460; See PMID 8246972; See PMID 1833637; See PMID 1922073; uncharacterized protein 2333650 4982310 An07g10400 Aspergillus niger uncharacterized protein XP_001392116.1 2330258 D 5061 CDS An07g10410 4982311 complement(join(2333875..2334546,2334613..2334900)) IV 1 NT_166523.1 Title: strong similarity to metalloprotease Mep1 -Metarhizium anisopliae; See PMID 8053668; uncharacterized protein 2334900 4982311 An07g10410 Aspergillus niger uncharacterized protein XP_059603856.1 2333875 R 5061 CDS An07g10420 4982312 complement(join(2335322..2335421,2335478..2335640,2335692..2336406,2336461..2336557,2336605..2336641,2336707..2336803)) IV 1 NT_166523.1 Function: cdc50-1 mutant arrests at START in G1 phase at the non-permissive temperature.; Phenotype: CDC50 mutants in S. cerevisiae are cold sensitive, sensitive to trifluoperazine, ZnCl2, CoCl2 and MnCl2.; Remark: CDC50 of S. cerevisiae is also called YCR094w.; Title: strong similarity to cell division cycle protein Cdc50 - Saccharomyces cerevisiae; See PMID 6749598; See PMID 11180453; uncharacterized protein 2336803 4982312 An07g10420 Aspergillus niger uncharacterized protein XP_001392118.1 2335322 R 5061 CDS An07g10430 4982313 complement(2337631..2338761) IV 1 NT_166523.1 Remark: FUN19 of S. cerevisiae is also called YAL034C.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to hypothetical protein Fun19 - Saccharomyces cerevisiae; uncharacterized protein 2338761 4982313 An07g10430 Aspergillus niger uncharacterized protein XP_001392119.3 2337631 R 5061 CDS An07g10440 84591552 join(2339013..2339117,2339240..2339265,2339377..2339476,2339642..2339742,2340053..2340099,2340152..2340273) IV 1 NT_166523.1 hypothetical protein 2340273 84591552 An07g10440 Aspergillus niger hypothetical protein XP_059603857.1 2339013 D 5061 CDS An19g00010 84593782 complement(join(3722..3888,4025..4071,4153..4224,4258..4324,4464..4599,4657..5082,5136..5367,5416..5461,5533..5560,5632..5668,5725..5906)) IV 1 NT_166538.4 Title: similarity to hypothetical protein CAD60780.1 - Podospora anserina; uncharacterized protein 5906 84593782 An19g00010 Aspergillus niger uncharacterized protein XP_059605046.1 3722 R 5061 CDS An19g00030 84593783 join(7902..8223,8270..8535) IV 1 NT_166538.4 Title: similarity to hypothetical protein At2g14560 - Arabidopsis thaliana; uncharacterized protein 8535 84593783 An19g00030 Aspergillus niger uncharacterized protein XP_059605047.1 7902 D 5061 CDS An19g00040 84593784 join(10120..10334,10449..10471,10632..10711,10885..10957,11026..11057,11109..11129) IV 1 NT_166538.4 Title: weak similarity to hypothetical protein encoded by An15g06860 - Aspergillus niger; uncharacterized protein 11129 84593784 An19g00040 Aspergillus niger uncharacterized protein XP_059605048.1 10120 D 5061 CDS An19g00050 84593785 complement(join(12344..12652,12701..13239,13280..13572,13634..13665)) IV 1 NT_166538.4 Title: similarity to hypothetical negative acting factor related protein B3E4.130 - Neurospora crassa; uncharacterized protein 13665 84593785 An19g00050 Aspergillus niger uncharacterized protein XP_059605049.1 12344 R 5061 CDS An19g00060 84593786 complement(join(13794..15234,15300..15793)) IV 1 NT_166538.4 Title: strong similarity to hypothetical protein SMb20006 - Sinorhizobium meliloti; uncharacterized protein 15793 84593786 An19g00060 Aspergillus niger uncharacterized protein XP_059605050.1 13794 R 5061 CDS An19g00070 84593787 complement(join(16981..17163,17223..17828)) IV 1 NT_166538.4 hypothetical protein 17828 84593787 An19g00070 Aspergillus niger hypothetical protein XP_059605051.1 16981 R 5061 CDS An19g00080 84593788 join(18270..18658,18712..19213) IV 1 NT_166538.4 Similarity: the predicted A. niger protein shows similarity to domains of ankyrin.; Title: similarity to ankyrin 2 Ank2 - Drosophila melanogaster; See PMID 10810176; See PMID 10844021; uncharacterized protein 19213 84593788 An19g00080 Aspergillus niger uncharacterized protein XP_059605052.1 18270 D 5061 CDS An19g00090 84593789 complement(join(19592..21072,21133..21636,21702..22467,22536..22802,22863..23123,23175..23350,23408..23441,23492..23977)) IV 1 NT_166538.4 Catalytic activity: Cmg1 catalyzes the successive hydrolysis of beta-D-glucose units from the non-reducing ends of 1,3-beta-D-glucans, releasing alpha-glucose.; Function: the 1,3-beta-glucosidase Cmg1 from Coniothyrium minitans is involved in cell wall degradation of the host fungi.; Remark: during sclerotial infection of Sclerotinia sclerotiorum the mycoparasite Coniothyrium minitans penetrates through the host cell wall.; Title: strong similarity to exo-beta-1,3-glucanase Cmg1 - Coniothyrium minitans; extracellular/secretion proteins; See PMID 11157256; uncharacterized protein 23977 84593789 An19g00090 Aspergillus niger uncharacterized protein XP_059605053.1 19592 R 5061 CDS An19g00100 84593790 join(25786..25916,25990..26023,26090..26204,26276..27079,27140..27299,27373..28174,28253..29548) IV 1 NT_166538.4 Catalytic activity: hydrolysis of the 1,4-beta-linkages of N-acetyl-D-glucosamine polymers of chitin.; Similarity: the ORF encoded protein shows strongest similarity to the chitinase ChiC from Aspergillus nidulans which is still unpublished.; Title: similarity to chitinase Eh cht1 - Entamoeba invadens; See PMID 9106188; uncharacterized protein 29548 84593790 An19g00100 Aspergillus niger uncharacterized protein XP_059605054.1 25786 D 5061 CDS An19g00110 84593791 join(30745..30873,31205..31315,31373..31570,31691..33289) IV 1 NT_166538.4 Title: similarity to hypothetical protein encoded by An12g05110 - Aspergillus niger; uncharacterized protein 33289 84593791 An19g00110 Aspergillus niger uncharacterized protein XP_059605055.1 30745 D 5061 CDS An19g00120 84593792 complement(join(34850..35415,35482..35666,35726..35799)) IV 1 NT_166538.4 Function: the AKT2 gene from Alternaria alternata encodes a protein of unknown function, which is essential for AK-toxin production and pathogenicity.; Remark: the Japanese pear pathotype of Alternaria alternata causes black spot of Japanese pear by producing a host-specific toxin known as AK-toxin.; Title: similarity to protein required for biosynthesis of the host-specific AK-toxin Akt2 -Alternaria alternata; See PMID 10432635; See PMID 10975654; uncharacterized protein 35799 84593792 An19g00120 Aspergillus niger uncharacterized protein XP_059605056.1 34850 R 5061 CDS An19g00130 84593793 complement(join(<37276..37679,37725..37934,38017..38436)) IV 1 NT_166538.4 Remark: alternate name for S. cerevisiae Hxt2: YMR011w.; Repression: high concentrations of glucose lead to the redistribution of S. cerevisiae HEX2 to the vacuole.; Repression: low-glucose-induced expression of S. cerevisiae HEX2 is mediated by two independent repression mechanisms, in the absence of glucose, transcription is prevented by Rgt1p, a C6 zinc cluster protein; at high levels of glucose, expression is repressed by Mig1p.; Title: similarity to glucose transport protein Hxt2 - Saccharomyces cerevisiae [putative frameshift]; plasma membrane; putative frameshift; See PMID 8816466; See PMID 10191260; uncharacterized protein 38436 84593793 An19g00130 Aspergillus niger uncharacterized protein XP_059605057.1 37276 R 5061 CDS An19g00140 84593794 complement(join(39355..39659,39715..40099,40164..40424)) IV 1 NT_166538.4 Catalytic activity: Carnitine + NAD(+) <=> 3-dehydrocarnitine + NADH.; Title: strong similarity to carnitine dehydrogenase from patent JP05161492-A - Alcaligenes sp.; uncharacterized protein 40424 84593794 An19g00140 Aspergillus niger uncharacterized protein XP_059605058.1 39355 R 5061 CDS An19g00150 84593795 join(41723..41953,42017..42805) IV 1 NT_166538.4 Function: formyl-CoA transferase of O. formigenes transfers a CoA moiety from formyl-CoA to oxalate to activate oxalic acid.; Remark: oxalic acid is a highly toxic by-product of metabolism, which is catabolized by a limited number of bacterial species.; Similarity: the ORF and formyl-CoA transferase of O. formigenes show local N-terminal similarity (along a stretch of about 200 amino acids).; Similarity: the ORF is shorter than formyl-CoA transferase of O. formigenes (339 compared to 428 amino acids).; Similarity: the ORF shows also similarity to (putative) racemases or transferases of other species.; Title: similarity to formyl-CoA transferase from patent WO9816632-A1 - Oxalobacter formigenes; See PMID 9150242; See PMID 2361939; uncharacterized protein 42805 84593795 An19g00150 Aspergillus niger uncharacterized protein XP_059605059.1 41723 D 5061 CDS An19g00160 84593796 complement(join(43105..43487,43574..43785,43882..44301,44352..45204,45274..45412)) IV 1 NT_166538.4 Function: facB of A. nidulans is required for acetate induction of acetamidase (amdS) and the acetate utilization enzymes acetyl-CoA synthase (facA), isocitrate lyase (acuD) and malate synthase (acuE).; Remark: facB of A. nidulans is a transcriptional activator with a GAL4-type Zn(II)2Cys6 zinc binuclear cluster DNA-binding domain.; Similarity: the ORF is shorter than facB of A. nidulans (668 compared to 867 amino acids).; Similarity: the ORF shows local N-terminal similarity with facB of A. nidulans (over a stretch of about 300 amino acids).; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; See PMID 9524126; uncharacterized protein 45412 84593796 An19g00160 Aspergillus niger uncharacterized protein XP_059605060.1 43105 R 5061 CDS An19g00170 84593797 45815..46741 IV 1 NT_166538.4 Function: LRP5 of H. sapiens binds apolipoprotein E (apoE).; Function: LRP5 of H. sapiens is a low density lipoprotein receptor (LDLR)-related protein.; Remark: LRP5 of H. sapiens is genetically associated with Type 1 diabetes.; Remark: LRP5 of H. sapiens shows similarity to the low density lipoprotein receptor class A (LDLRA) domain.; Similarity: the ORF is much shorter than LRP5 of H. sapiens (308 compared to 1615 amino acids).; Similarity: the ORF shows local similarity to LRP5 of H. sapiens over a C-terminal stretch of about 190 amino acids.; Title: similarity to low density lipoprotein receptor related protein LRP5 from patent WO9846743-A1 -Homo sapiens; See PMID 9832610; See PMID 10990489; uncharacterized protein 46741 84593797 An19g00170 Aspergillus niger uncharacterized protein XP_059605061.1 45815 D 5061 CDS An19g00180 84593798 complement(join(46956..47306,47359..47779,47828..48234,48286..48609)) IV 1 NT_166538.4 Function: DAL5 of S. cerevisiae is an integral membrane protein, transporting allantoate via the plasma membrane.; Phenotype: disruption of DAL5 of S. cerevisiae leads to viable cells, unable to transport allontoate or ureidosuccinate.; Remark: DAL5 of S. cerevisiae belongs to the allantoate permease family.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 3275614; uncharacterized protein 48609 84593798 An19g00180 Aspergillus niger uncharacterized protein XP_059605062.1 46956 R 5061 CDS An19g00190 84593799 join(48907..49018,49098..49184,49280..49611) IV 1 NT_166538.4 hypothetical protein 49611 84593799 An19g00190 Aspergillus niger hypothetical protein XP_059605063.1 48907 D 5061 CDS An19g00200 84593800 join(49739..50117,50154..50408,50487..50671,50719..50766) IV 1 NT_166538.4 Title: strong similarity to hypothetical protein 99H12.80 - Neurospora crassa [putative sequencing error]; putative sequencing error; uncharacterized protein 50766 84593800 An19g00200 Aspergillus niger uncharacterized protein XP_059605064.1 49739 D 5061 CDS An19g00210 84593801 complement(join(51269..51596,51671..51771)) IV 1 NT_166538.4 Function: hemolysin of A. fumigatus is a cytolytic toxin, lytic for erythrocytes of humans, rabbits and sheep.; Remark: hemolysin of A. fumigatus is inactivated by the addition of serum or blood plasma.; Similarity: the ORF overlaps with A. niger ESTs (e. g. an_3635 in EMBLEST:BE759282, an_2964 in EMBLEST:BE760009, an_3529 in EMBLEST:BE759189, NO:4040 in PATENTDNA:AAF11517, and NO:4110 in PATENTDNA:AAF11587).; Title: similarity to hemolysin ASP-HS - Aspergillus fumigatus; See PMID 8086452; See PMID 11433776; uncharacterized protein 51771 84593801 An19g00210 Aspergillus niger uncharacterized protein XP_059605065.1 51269 R 5061 CDS An19g00220 84593802 join(52071..52232,52316..52489,52579..52650,52993..53066,53179..53569) IV 1 NT_166538.4 Remark: the predicted ORF contains relatively long introns.; hypothetical protein 53569 84593802 An19g00220 Aspergillus niger hypothetical protein XP_059605066.1 52071 D 5061 CDS An19g00230 84593803 complement(join(54096..54377,54442..54763,54820..54884,54952..55389,55591..55812)) IV 1 NT_166538.4 Catalytic activity: thyrosinases catalyse L-tyrosine + L-DOPA + O(2) <=> L-DOPA + DOPAquinone + H(2)O.; Function: melC of S. antibioticus is a thyrosinase,which binds copper and functions in the formation of pigments such as melanins and other polyphenolic compounds.; Similarity: the ORF overlaps with A. niger EST (EMBLEST:BE760551) an_1878.; Similarity: the similarity of the ORF to mel of S. antibioticus is restricted to the C. terminus of the ORF,starting which amino acid 158, with is homologues to amino acid 1 of the S. antibioticus protein.; Title: similarity to monophenol monooxygenase melC2 - Streptomyces antibioticus; See PMID 2107124; uncharacterized protein 55812 84593803 An19g00230 Aspergillus niger uncharacterized protein XP_059605067.1 54096 R 5061 CDS An19g00240 84593804 complement(join(56687..57111,57158..57403,57454..57737,57818..58212)) IV 1 NT_166538.4 Title: strong similarity to hypothetical protein encoded by An17g00130 - Aspergillus niger; uncharacterized protein 58212 84593804 An19g00240 Aspergillus niger uncharacterized protein XP_059605068.1 56687 R 5061 CDS An19g00250 84593805 join(58271..58386,58471..58611,58713..58763,58883..59027,59507..59713,59787..59881,60136..60268,60753..60839,61088..61159,61461..61619) IV 1 NT_166538.4 Remark: the predicted ORF contains relatively long introns.; hypothetical protein 61619 84593805 An19g00250 Aspergillus niger hypothetical protein XP_059605069.1 58271 D 5061 CDS An19g00260 84593806 join(61855..61953,62043..62142,62203..62306,62394..62495,62598..62662,63172..63329,63668..63804,63893..64024,64106..64224,64333..64402,64546..64698) IV 1 NT_166538.4 Remark: the ORF shows local similarity to a short stretch of 101 bases to the published A. niger pectin lyase D gene sequence (probably the 5' untranslated region),which is located 3' to this ORF (100wg).; hypothetical protein 64698 84593806 An19g00260 Aspergillus niger hypothetical protein XP_059605070.1 61855 D 5061 CDS An19g00270 84593807 join(64874..65073,65139..65282,65345..65470,65534..65630,65688..66242) IV 1 NT_166538.4 Function: the A. niger pectin lyase D gene serves in a expression system for recombinant proteins in A. niger,which can be induced by adding pectin to the culture medium.; Gene-ID: pelD; Remark: pelD was previously described as pectin lyase I (Van Houdenhoven, Ph. D. Thesis, Wageningen,1975).; Remark: the ORF sequence differs at amino acid 10 (I10V) from the published database sequence (PIR:JH0155).; pectin lyase pelD-Aspergillus niger 66242 pelD 84593807 pelD Aspergillus niger pectin lyase pelD-Aspergillus niger XP_059605071.1 64874 D 5061 CDS An19g00280 84593808 join(66819..66951,67035..68188) IV 1 NT_166538.4 Remark: the N-terminus of the ORF overlaps with the published sequence of the pelD gene of A. niger, probably the 3' untranslated region.; Similarity: the predicted ORF overlaps with the C-terminal region of the putative D. melanogaster protein CG12065, but is 303 amino acids shorter at the N-terminus.; Title: similarity to hypothetical protein CG12065 -Drosophila melanogaster; uncharacterized protein 68188 84593808 An19g00280 Aspergillus niger uncharacterized protein XP_059605072.1 66819 D 5061 CDS An19g00290 84593809 complement(join(68737..69635,69685..69760)) IV 1 NT_166538.4 Function: human PDGH catalyzes the oxidation of many prostaglandins at C-15, resulting in a subsequent reduction in their biological activity.; Similarity: the a. niger protein shows similarity to several prostaglandin dehydrogenases and 3-oxoacyl-(acyl-carrier protein) reductases.; Title: similarity to NAD+-dependent 15-hydroxyprostaglandin dehydrogenase PDGH - Homo sapiens; See PMID 1697582; uncharacterized protein 69760 84593809 An19g00290 Aspergillus niger uncharacterized protein XP_059605073.1 68737 R 5061 CDS An19g00300 84593810 complement(70681..72051) IV 1 NT_166538.4 Function: Kinesins are ATPases specifically moving in the direction of the positive or negative end of microtubuli, the light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.; Remark: the A. niger protein shows similarity to kinesin light chains of different organisms.; Title: strong similarity to kinesin light chain KLC - Plectonema boryanum; cytoskeleton; See PMID 9212172; See PMID 10754574; See PMID 11212346; uncharacterized protein 72051 84593810 An19g00300 Aspergillus niger uncharacterized protein XP_059605074.1 70681 R 5061 CDS An19g00310 84593811 join(72379..72555,72630..72845) IV 1 NT_166538.4 hypothetical protein 72845 84593811 An19g00310 Aspergillus niger hypothetical protein XP_059605075.1 72379 D 5061 CDS An19g00320 84593812 join(73214..73585,73652..74327,74411..74454,74511..74645) IV 1 NT_166538.4 Function: S. cerevisiae VCX1 is a H+/Ca2+ exchanger responsible for maintaining low cytosolic-free Ca2+ concentrations by catalyzing pH gradient-energized vacuolar Ca2+ accumulation.; Regulation: activity of S. cerevisiae VCX1 is inhibited by calcineurin, a Ca2+/calmodulin-dependent protein phosphatase, mainly by posttranslational mechanisms.; Remark: HUM1, D2218 and YDL128 are alternative names for VCX1.; Title: strong similarity to vacuolar H(+)/Ca(2+) exchanger Vcx1 - Saccharomyces cerevisiae; vacuole; See PMID 8628289; uncharacterized protein 74645 84593812 An19g00320 Aspergillus niger uncharacterized protein XP_059605076.1 73214 D 5061 CDS An19g00330 84593813 complement(join(74843..75640,75702..76136)) IV 1 NT_166538.4 Function: S. cerevisiae VCX1 is a H+/Ca2+ exchanger responsible for maintaining low cytosolic-free Ca2+ concentrations by catalyzing pH gradient-energized vacuolar Ca2+ accumulation.; Regulation: activity of S. cerevisiae VCX1 is inhibited by calcineurin, a Ca2+/calmodulin-dependent protein phosphatase, mainly by posttranslational mechanisms.; Remark: HUM1, D2218 and YDL128 are alternative names for VCX1.; Title: strong similarity to vacuolar H(+)/Ca(2+) exchanger Vcx1 - Saccharomyces cerevisiae; vacuole; See PMID 8628289; uncharacterized protein 76136 84593813 An19g00330 Aspergillus niger uncharacterized protein XP_059605077.1 74843 R 5061 CDS An19g00340 84593814 join(76742..77041,77096..77179,77235..77956,78052..78163) IV 1 NT_166538.4 Function: S. cerevisiae VCX1 is a H+/Ca2+ exchanger responsible for maintaining low cytosolic-free Ca2+ concentrations by catalyzing pH gradient-energized vacuolar Ca2+ accumulation.; Regulation: activity of S. cerevisiae VCX1 is inhibited by calcineurin, a Ca2+/calmodulin-dependent protein phosphatase, mainly by posttranslational mechanisms.; Remark: HUM1, D2218 and YDL128 are alternative names for VCX1.; Title: strong similarity to vacuolar H(+)/Ca(2+) exchanger Vcx1 - Saccharomyces cerevisiae; vacuole; See PMID 8628289; uncharacterized protein 78163 84593814 An19g00340 Aspergillus niger uncharacterized protein XP_059605078.1 76742 D 5061 CDS An19g00350 84593815 join(78434..78547,78794..81268,81330..81712,81763..82066) IV 1 NT_166538.4 Function: pmc1 of S. cerevisiae pumps Ca2+ into the vacuole and participates in the control of the cytosolic free calcium together with atc1 protein.; Phenotype: mutations in calcineurin A or B subunits or the inhibitory compounds FK506 and cyclosporin A restore growth of pmc1 mutants in high Ca2+ media.; Remark: alternate names for pmc1 of S. cerevisiae are G3749 or YGL006w.; Repression: the growth of S. cerevisae pmc1 mutants is inhibited by added Ca2+ only after activation of calcineurin.; Title: strong similarity to calcium-transporting ATPase Pmc1 - Saccharomyces cerevisiae; vacuole; See PMID 7507493; uncharacterized protein 82066 84593815 An19g00350 Aspergillus niger uncharacterized protein XP_059605079.1 78434 D 5061 CDS An19g00360 84593816 complement(join(82722..83436,83547..83952,84025..84366,84450..84746,84988..84998,85257..85384,85500..85737,85815..86209)) IV 1 NT_166538.4 Title: similarity to hypothetical protein encoded by An08g05310 - Aspergillus niger; uncharacterized protein 86209 84593816 An19g00360 Aspergillus niger uncharacterized protein XP_059605080.1 82722 R 5061 CDS An19g00370 84593817 join(87167..87658,87694..88214,88339..88462,88528..88635) IV 1 NT_166538.4 Title: similarity to hypothetical protein encoded by An15g02550 - Aspergillus niger; uncharacterized protein 88635 84593817 An19g00370 Aspergillus niger uncharacterized protein XP_059605081.1 87167 D 5061 CDS An19g00380 84593818 join(89257..89685,89742..90689) IV 1 NT_166538.4 Catalytic activity: (R)-6-hydroxynicotine + H(2)O + O(2) <=> 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H(2)O(2).; Cofactor: FAD.; Similarity: the ORF encoded protein shows similarity to many hypothetical flavoprotein oxidoreductases. The similarity of the ORF encoded protein to the 6-hydroxy-D-nicotine oxidase 6-HDNO from A. oxidans only concerns the N-terminal protein part.; Title: similarity to 6-hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 2115879; See PMID 2680607; See PMID 3622516; uncharacterized protein 90689 84593818 An19g00380 Aspergillus niger uncharacterized protein XP_059605082.1 89257 D 5061 CDS An19g00390 84593819 join(91366..91925,91979..92234) IV 1 NT_166538.4 Function: verA of A. nidulans catalyzes the conversion of versicolorin a to sterigmatocystin.; Pathway: verA of A. nidulans catalyzes a step in the sterigmatocystin synthesis pathway.; Remark: the A. niger protein shows similarity to different reductases.; Similarity: verA of A. nidulans belongs to the short-chain dehydrogenases/reductases family (SDR).; Title: strong similarity to versicolorin reductase verA - Aspergillus nidulans; See PMID 8017929; See PMID 8643646; uncharacterized protein 92234 84593819 An19g00390 Aspergillus niger uncharacterized protein XP_059605083.1 91366 D 5061 CDS An19g00400 84593820 join(92629..92708,92776..92984,93041..93456) IV 1 NT_166538.4 Title: weak similarity to suppressor of cdc25 mutations Tfs1 - Saccharomyces cerevisiae; uncharacterized protein 93456 84593820 An19g00400 Aspergillus niger uncharacterized protein XP_059605084.1 92629 D 5061 CDS An19g00410 84593821 complement(93878..94444) IV 1 NT_166538.4 Title: strong similarity to hypothetical protein SA2438 - Staphylococcus aureus; uncharacterized protein 94444 84593821 An19g00410 Aspergillus niger uncharacterized protein XP_059605085.1 93878 R 5061 CDS An19g00420 84593822 join(94783..95046,95105..96382) IV 1 NT_166538.4 Remark: YBR180w is the systematic name for S. cerevisiae DTR1.; Remark: information regarding S. cerevisiae DTR1 has not yet been published and is available via http://genome-www. stanford. edu/cgi-bin/SGD/genehunter.; Similarity: S. cerevisiae DTR1 belongs to the major facilitator family of transport proteins.; Title: strong similarity to dityrosine transporter Dtr1 - Saccharomyces cerevisiae; See PMID 8720066; uncharacterized protein 96382 84593822 An19g00420 Aspergillus niger uncharacterized protein XP_059605086.1 94783 D 5061 CDS An10g00010 4990273 complement(join(59..225,296..391,446..1319)) V 1 NT_166537.1 Catalytic activity: alcohol dehydrogenases catalyze the reversible reaction alcohol + NAD(+) <=> aldehyde or ketone + NADH.; Cofactor: members of this family of alchool dehydrogenases require Zn for their activity, and use NAD or NADP as electron exchangers.; Similarity: adhB of T. ethanolicus belongs to the zinc-containing alcohol dehydrogenase family.; Similarity: the predicted ORF shows strong similarity with a number of known and putative alcohol and aldehyde dehydrogenases, with very wide substrate specificities.; Title: strong similarity to alcohol dehydrogenase (NADP+) adhB - Thermoanaerobacter ethanolicus; See PMID 8645192; uncharacterized protein 1319 4990273 An10g00010 Aspergillus niger uncharacterized protein XP_001402395.1 59 R 5061 CDS An10g00020 84592094 complement(join(2005..2205,2224..2481)) V 1 NT_166537.1 Function: A. oligospora is a nematophagous fungus; the surface lectin is involved in capture of the worms.; Function: lectins in general are proteins which specifically bind or crosslink carbohydrates.; Function: the surface lectin of A. oligospora shows haemagglutinating activity inhibited by the glycoproteins mucin and fetuin.; Localization: the protein is soluble and secreted,and remains associated with extracellular polymer layers and with the cell wall of the fungus.; Title: similarity to hemagglutinating surface lectin - Arthrobotrys oligospora; extracellular/secretion proteins; See PMID 1487732; See PMID 8706686; uncharacterized protein 2481 84592094 An10g00020 Aspergillus niger uncharacterized protein XP_059601489.1 2005 R 5061 CDS An10g00030 84592095 complement(join(4171..4253,4444..4653,4711..4850,4910..5081,5163..5237,5279..>5348)) V 1 NT_166537.1 Remark: similarity to C. glutamicum patented sequence and to other hypothetical proteins, which are all longer of the predicted ORF, and the position at the contig border, suggest that this could be a N-terminally truncated gene model.; Title: similarity to sequence 211 from patent WO0100842 - Corynebacterium glutamicum [truncated ORF]; uncharacterized protein 5348 84592095 An10g00030 Aspergillus niger uncharacterized protein XP_059601490.1 4171 R 5061 CDS An10g00040 84592096 complement(join(<5468..5831,5899..5991)) V 1 NT_166537.1 Function: the protein of sequence 211 from Patent WO0100842 is involved in homeostasis and adaptation.; Remark: the ORF is C-terminally truncated due to end of contig.; Similarity: shows similarity to several proteins homologous to N-benzoylamino-acid amidohydrolase (EC 3. 5. 1. 32; hippurate hydrolase) and/or similar amino-/amidohydrolases.; Title: strong similarity to sequence 211 from patent WO0100842 - Corynebacterium glutamicum [truncated ORF]; uncharacterized protein 5991 84592096 An10g00040 Aspergillus niger uncharacterized protein XP_059605840.1 5468 R 5061 CDS An10g00050 4990262 join(6512..6524,6833..6973,7042..7163,7219..7750,7818..8473) V 1 NT_166537.1 Function: Flu1p of C. albicans confers resistance to various antibiotics including fluconazole and cycloheximide.; Similarity: FLU1 of C. albicans belongs to the major facilitator superfamily.; Similarity: the N-terminus appears about 120aa shorter than in FLU1 of C. albicans.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353; uncharacterized protein 8473 4990262 An10g00050 Aspergillus niger uncharacterized protein XP_001402399.3 6512 D 5061 CDS An10g00060 84592097 join(9268..9319,9414..9726,9812..10511) V 1 NT_166537.1 Function: aflR of A. sojae is involved in the regulation of aflatoxin biosynthesis.; Similarity: shares a fungal-type Zn(2)-Cys(6) binuclear cluster with a number of proteins involved in transcriptional regulation.; Title: weak similarity to transcription regulator aflR - Aspergillus sojae; uncharacterized protein 10511 84592097 An10g00060 Aspergillus niger uncharacterized protein XP_059605841.1 9268 D 5061 CDS An10g00070 4990277 join(10998..11414,11498..11994,12080..>12174) V 1 NT_166537.1 Catalytic activity: 2 sulfhydryl groups + O2 = disulphide + H2O2.; Function: SOX of A. niger is a FAD-linked oxidoreductase containing redox-active disulphide centres.; Function: SOX of A. niger is involved in the formation of disulphide bounds, eg in proteins.; Remark: possible sequencing error at position 5789 leading to a frameshift.; Similarity: also shows similarity to various NADH oxidases.; Similarity: also shows similarity to various thioredoxin reductases and alkyl hydroperoxide reductases involved in oxidative stress response.; Similarity: belongs to the pyridine nucleotide-disulphide oxidoreductase class-II family.; Title: strong similarity to sulphydryl oxidase Sox from patent EP565172-A1 - Aspergillus niger [putative frameshift]; putative frameshift; See PMID 3427078; uncharacterized protein 12174 4990277 An10g00070 Aspergillus niger uncharacterized protein XP_059605842.1 10998 D 5061 CDS An10g00080 84592098 join(13288..13497,13573..13658,13702..13887,14097..14340) V 1 NT_166537.1 hypothetical protein 14340 84592098 An10g00080 Aspergillus niger hypothetical protein XP_059605843.1 13288 D 5061 CDS An10g00090 84592099 join(15365..15879,15999..16068) V 1 NT_166537.1 Similarity: to cDNA patent PATENTDNA:A27119.; Title: weak similarity to NADP-specific glutamate dehydrogenase from patent WO200028006-A2 - Glycine max; uncharacterized protein 16068 84592099 An10g00090 Aspergillus niger uncharacterized protein XP_059605844.1 15365 D 5061 CDS An10g00100 4990263 join(17569..18306,18384..19579,19689..19755,19875..20378) V 1 NT_166537.1 Function: amdR of A. oryzae activates genes necessary for the catabolism of certain amids and lactams and for the utilization of omega-amino acids, eg GABA.; Title: similarity to transcription regulator amdR -Aspergillus oryzae; See PMID 1452021; uncharacterized protein 20378 4990263 An10g00100 Aspergillus niger uncharacterized protein XP_059605845.1 17569 D 5061 CDS An10g00110 4990254 complement(join(21223..22669,22720..22783,22879..22981)) V 1 NT_166537.1 Catalytic activity: ordA of A. parasiticus converts O-methylsterigmatocystin and dihydro-O-methylsterigmatocystin to aflatoxins B1 or G1 and B2 or G2, respectively.; Pathway: ordA of A. parasiticus is required for the biosynthesis of aflatoxins B1, G1, B2, and G2.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Similarity: ordA of A. parasiticus belongs to the CYP64 family of cytochromes P-450.; Title: strong similarity to O-methylsterigmatocystin oxidoreductase ordA - Aspergillus parasiticus; See PMID 9835571; See PMID 10473388; uncharacterized protein 22981 4990254 An10g00110 Aspergillus niger uncharacterized protein XP_001402405.1 21223 R 5061 CDS An10g00120 4990274 complement(join(23276..24330,24392..24443)) V 1 NT_166537.1 Catalytic activity: 2,3-dihydroxybenzoic acid + H2O = catechol + HCO3(-).; Function: useful for production of catechol and related aromatic hydrocarbons.; Title: similarity to 2,3-dihydroxybenzoic acid decarboxylase from patent WO9909048-A1 - Aspergillus niger; uncharacterized protein 24443 4990274 An10g00120 Aspergillus niger uncharacterized protein XP_001402406.3 23276 R 5061 CDS An10g00130 84592100 complement(join(24910..25624,25794..25927)) V 1 NT_166537.1 Catalytic activity: 4-hydroxibenzoic acid + polyprenyl-diphosphate = 3-polyprenyl-4-hydroxybenzoic acid + pyrophosphate.; Pathway: ppt1 of S. pombe catalyzes the condensation of para-hydroxybenzoate and polyprenyl diphosphate in ubiquinone biosynthesis.; Title: strong similarity to para-hydroxybenzoate--polyprenyltransferase ppt1p -Schizosaccharomyces pombe; localisation:mitochondrion; See PMID 11092853; uncharacterized protein 25927 84592100 An10g00130 Aspergillus niger uncharacterized protein XP_059605846.1 24910 R 5061 CDS An10g00140 4990260 26316..31655 V 1 NT_166537.1 Pathway: atX of A. terreus is required for the biosynthesis of the polyketide 6-methylsalicylic acid.; Similarity: belongs to the family of fungal MSAS-type polyketide synthases.; Similarity: contains the beta-ketoacyl synthase catalytic domain, the acyl transferase domain and phosphopantetheine attachment site of polyketide synthases.; Title: strong similarity to 6-methylsalicylic acid synthase atX - Aspergillus terreus; See PMID 9003280; See PMID 10361035; uncharacterized protein 31655 4990260 An10g00140 Aspergillus niger uncharacterized protein XP_001402408.3 26316 D 5061 CDS An10g00150 4990276 complement(join(32883..33042,33093..33373,33447..33767,33856..34064,34133..34545,34631..34773)) V 1 NT_166537.1 Function: TRI4 of M. roridum is a cytochrome P450-type monooxygenase.; Pathway: TRI4 of M. roridum catalyzes the initial oxygenation step in the biosynthesis pathway of trichothecene toxin.; Remark: trichothecenes are sesquiterpenoid mycotoxins and act as protein synthesis inhibitors for eukaryotic organisms.; Title: strong similarity to cytochrome P450 monooxygenase TRI4 - Myrothecium roridum; See PMID 9529523; uncharacterized protein 34773 4990276 An10g00150 Aspergillus niger uncharacterized protein XP_059605847.1 32883 R 5061 CDS An10g00160 4990255 join(34980..35767,35875..36097) V 1 NT_166537.1 hypothetical protein 36097 4990255 An10g00160 Aspergillus niger hypothetical protein XP_059605848.1 34980 D 5061 CDS An10g00170 4990271 complement(join(36671..36782,36843..37723)) V 1 NT_166537.1 Catalytic activity: alcohol + NAD(P)(+) = corresponding aldehyde or keton + NAD(P)H + H(+).; Function: many SCAD family members are involved in steroid metabolism.; Similarity: belongs to the superfamily of short chain alcohol dehydrogenases (SCAD).; Title: strong similarity to protein sequence 79 from patent WO0129221 - Homo sapiens; uncharacterized protein 37723 4990271 An10g00170 Aspergillus niger uncharacterized protein XP_001402411.1 36671 R 5061 CDS An10g00180 4990275 join(38525..39010,39094..39381) V 1 NT_166537.1 Title: weak similarity to hypothetical protein encoded by An02g10900 - Aspergillus niger; uncharacterized protein 39381 4990275 An10g00180 Aspergillus niger uncharacterized protein XP_001402412.1 38525 D 5061 CDS An10g00190 4990258 join(40256..40862,40923..41075,41129..41665,41738..41948,42096..42249) V 1 NT_166537.1 Function: CHO of patent WO9931990-A1 oxidizes the reducing end of oligosaccharides with preference over the corresponding monosaccharides.; Title: similarity to carbohydrate oxidase CHO from patent WO9931990-A1 - Microdochium nivale; uncharacterized protein 42249 4990258 An10g00190 Aspergillus niger uncharacterized protein XP_001402413.3 40256 D 5061 CDS An10g00210 4990265 complement(join(43219..43551,43604..43615)) V 1 NT_166537.1 hypothetical protein 43615 4990265 An10g00210 Aspergillus niger hypothetical protein XP_001402414.1 43219 R 5061 CDS An10g00220 4990267 complement(join(44965..45073,45124..45296,45346..45448,45499..45855,45919..46012,46073..46175)) V 1 NT_166537.1 Title: similarity to hypothetical protein CAE07943.1 - Synechococcus sp.; uncharacterized protein 46175 4990267 An10g00220 Aspergillus niger uncharacterized protein XP_059605849.1 44965 R 5061 CDS An10g00230 4990269 join(46889..47005,47060..47085,47150..47193,47251..47424,47485..47514,47573..47668,47724..47738,47801..48179,48235..48307,48366..48602) V 1 NT_166537.1 Catalytic activity: formaldehyde + NAD(+) + H2O = formate + NADH.; Function: at high pH, fdhA of P. putida catalyses the oxidation of long-chain alcohols.; Function: fdhA of P. putida converts formaldehyde to formate.; Function: fdhA of P. putida requires zinc for it's activity.; Function: the activity of fdhA of P. putida is independent of reduced glutathione.; Similarity: belongs to the zinc-containing long-chain alcohol dehydrogenase family.; Title: strong similarity to glutathione-independent formaldehyde dehydrogenase fdhA - Pseudomonas putida; See PMID 8169197; uncharacterized protein 48602 4990269 An10g00230 Aspergillus niger uncharacterized protein XP_001402416.3 46889 D 5061 CDS An10g00240 4990270 complement(join(49433..50671,50771..50902)) V 1 NT_166537.1 Title: weak similarity to hypothetical protein T8P19.230 - Arabidopsis thaliana; uncharacterized protein 50902 4990270 An10g00240 Aspergillus niger uncharacterized protein XP_059605850.1 49433 R 5061 CDS An10g00250 4990278 complement(join(51935..52920,53023..53903,54303..54385,54554..54637)) V 1 NT_166537.1 Function: Cos1p of C. albicans is a two-component histidine kinase probably involved in nutrient deprivation response.; Function: Cos1p of C. albicans is involved in hyphal morphogenesis and probably plays a role in virulence properties of the organism.; Similarity: COS1 of C. albicans is identical to CaNIK-1.; Title: strong similarity to histidine kinase COS1 -Candida albicans; See PMID 9618540; uncharacterized protein 54637 4990278 An10g00250 Aspergillus niger uncharacterized protein XP_059605851.1 51935 R 5061 CDS An10g00260 4990279 complement(join(55423..55637,55677..55746)) V 1 NT_166537.1 Title: strong similarity to EST an_1399 -Aspergillus niger; uncharacterized protein 55746 4990279 An10g00260 Aspergillus niger uncharacterized protein XP_059605852.1 55423 R 5061 CDS An10g00270 84592101 join(56270..56409,56478..56552,56691..56741,57035..57194,57240..57362) V 1 NT_166537.1 hypothetical protein 57362 84592101 An10g00270 Aspergillus niger hypothetical protein XP_059605853.1 56270 D 5061 CDS An10g00280 4990281 complement(join(57787..59723,59811..59865)) V 1 NT_166537.1 Similarity: the predicted A. niger protein shows similarity to part of several DNA-binding proteins and contains a DNA-binding-protein motif.; Title: weak similarity to zinc-finger transcription factor WRKY1 - Petroselinum crispum; uncharacterized protein 59865 4990281 An10g00280 Aspergillus niger uncharacterized protein XP_059605854.1 57787 R 5061 CDS An10g00290 4990282 61895..64267 V 1 NT_166537.1 Similarity: the predicted A. niger protein shows similarity to a putative alpha-L-rhamnosidase from C. crescentus and weak similarity to V. cholerae beta-galactosidase.; Title: similarity to hypothetical protein SCF34.07 -Streptomyces coelicolor; uncharacterized protein 64267 4990282 An10g00290 Aspergillus niger uncharacterized protein XP_001402422.1 61895 D 5061 CDS An10g00300 4990283 join(64792..65033,65095..65405,65471..66161,66226..66631) V 1 NT_166537.1 Function: S. cerevisiae Mal1 is a complex genetic locus giving rise to hexose transporter Isoforms of different specifity, namely a maltose specific Isoforme,MAL11 and a general alpha-glucoside transporting Isomforme,AGT1.; Remark: the predicted A. niger protein might be alternatively spliced.; Remark: the systematic name for S. cerevisiae MAL11 isYGR289C, an alias is AGT1.; Title: similarity to alpha-glucoside-hydrogen symporter Mal11 - Saccharomyces cerevisiae; plasma membrane; See PMID 8594329; See PMID 1999393; uncharacterized protein 66631 4990283 An10g00300 Aspergillus niger uncharacterized protein XP_059605855.1 64792 D 5061 CDS An10g00310 4990284 complement(join(67019..67984,68050..68235,68291..68349,68397..68988)) V 1 NT_166537.1 Function: Iron and Copper uptake in S. cerevisiae involves at least two steps, reduction of ferric to ferrous ions extracellularly by the membrane-associated ferric reductases FRE1 and FRE2, and transport of the reduced ions through the plasma membrane.; Regulation: S. cerevisiae FRE2 expression, like FRE1 expression, is induced by iron and copper deprivation, and at least part of this control takes place at the transcriptional level mediated by Mac1.; Title: similarity to ferric/cupric reductase Fre2 -Saccharomyces cerevisiae; plasma membrane; See PMID 8164662; See PMID 10341420; uncharacterized protein 68988 4990284 An10g00310 Aspergillus niger uncharacterized protein XP_059605856.1 67019 R 5061 CDS An10g00320 4990285 71668..72408 V 1 NT_166537.1 Similarity: the predicted A. niger protein shows similarity to several hypothetical acetyltransferases and contains an acetyltransferase domain.; Title: strong similarity to hypothetical protein PA5433 - Pseudomonas aeruginosa; uncharacterized protein 72408 4990285 An10g00320 Aspergillus niger uncharacterized protein XP_001402425.1 71668 D 5061 CDS An10g00330 4990286 complement(73022..74011) V 1 NT_166537.1 Catalytic activity: dihydrodipicolinate synthases convert L-aspartate 4-semialdehyde + pyruvate to dihydrodipicolinate + 2 H(2)O.; Function: C. glutamicum dapA is involved in lysine biosynthesis.; Title: strong similarity to dihydrodipicolinate synthase dapA - Corynebacterium glutamicum; See PMID 8092856; See PMID 2129555; uncharacterized protein 74011 4990286 An10g00330 Aspergillus niger uncharacterized protein XP_001402426.1 73022 R 5061 CDS An10g00340 4990287 join(74529..74668,74723..74972,75038..75534,75606..75796,75851..75975) V 1 NT_166537.1 Function: M. grisea pth11 functions at the cell cortex as an upstream effector of appressorium differentiation in response to surface cues.; Pathway: in M. grisea multiple signaling pathways mediate induction of appressorium differentiation by pth11.; Title: similarity to PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529; uncharacterized protein 75975 4990287 An10g00340 Aspergillus niger uncharacterized protein XP_059605857.1 74529 D 5061 CDS An10g00350 4990288 complement(join(76273..76278,76333..76614,76668..77624,77684..77797)) V 1 NT_166537.1 Catalytic activity: GTP cyclohydrolases II convert GTP + 3 H(2)O to formate + 2,5-diamino-6-hydroxy-4-(5-CA-phosphoribosylamino)pyrimidi ne + diphosphate.; Function: A. pleuropneumoniae ribA is involved in the riboflavin metabolism.; Title: similarity to GTP cyclohydrolase II ribA -Actinobacillus pleuropneumoniae; See PMID 8522537; See PMID 10940330; uncharacterized protein 77797 4990288 An10g00350 Aspergillus niger uncharacterized protein XP_001402428.1 76273 R 5061 CDS An10g00360 4990289 complement(join(78685..78954,79019..79219,79269..79506,79559..80056,80124..80292,80394..80466)) V 1 NT_166537.1 Complex: in S. cerevisiae, a fraction of the Dbp5 protein associates with nuclear pore complexes (NPCs) on the cytoplasmic side.; Function: Dbp5 of S. cerevisiae is an RNA-dependent ATPase which participates in the export of mRNAs out of the nucleus.; Remark: the alternate name of Dbp5 in S. cerevisiae is RAT8.; Similarity: the protein is closely related to eukaryotic initiation factor 4A(eIF4A).; Title: strong similarity to nuclear pore-associated DEAD-box protein Dbp5 - Saccharomyces cerevisiae; nucleus; See PMID 9564048; See PMID 10428971; uncharacterized protein 80466 4990289 An10g00360 Aspergillus niger uncharacterized protein XP_001402429.1 78685 R 5061 CDS An10g00370 4990290 join(80934..81130,81266..81311,81501..82028,82078..82158,82208..83351,83406..83812) V 1 NT_166537.1 Function: CIP4 is a downstream target of activated GTP-bound Cdc42, and is similar in sequence to proteins involved in signalling and cytoskeletal control in human.; Function: CIP4 of human is regulating the assembly of the actin cytoskeleton.; Similarity: also C-terminally similarities to a protein contains two SH3 domains and a phorbol esters/diacylglycerol binding domain.; Title: similarity to Cdc42-interacting protein 4 CIP4 - Homo sapiens; See PMID 9210375; uncharacterized protein 83812 4990290 An10g00370 Aspergillus niger uncharacterized protein XP_059605858.1 80934 D 5061 CDS An10g00380 10098285 join(85887..85982,86346..86843) V 1 NT_166537.1 Similarity: the central part of the protein shows some weak similarity to clathrin assembly protein AP180 of Xenopus laevis due to alanine-rich regions.; hypothetical protein 86843 10098285 An10g00380 Aspergillus niger hypothetical protein XP_059605859.1 85887 D 5061 CDS An10g00390 4990292 complement(join(87906..88514,88582..89235,89327..90769)) V 1 NT_166537.1 Catalytic activity: cellobiose + O(2) = cellobiono-1, 5-lactone + H(2)O(2).; Function: the biological function of CDH is not fully understood, but recent results support a hydroxyl radical-generating mechanism whereby the radical can degrade and modify cellulose, hemicellulose and lignin.; Remark: CDH has found technical use in highly selective amperometric biosensors and several other applications have been suggested.; Title: strong similarity to cellobiose dehydrogenase CDH - Phanerochaete chrysosporium; extracellular/secretion proteins; See PMID 8919793; See PMID 10725534; See PMID 11063597; uncharacterized protein 90769 4990292 An10g00390 Aspergillus niger uncharacterized protein XP_001402432.1 87906 R 5061 CDS An10g00400 4990293 complement(join(92418..93191,93262..93864)) V 1 NT_166537.1 Function: glycosylphosphatidylinositol-anchored glucanosyltransferases play an active role in the biosynthesis of the fungal cell wall.; Similarity: strong similarity to beta(1-3)glucanosyltransferase BGT2 of A. fumigatus,patentnumber WO9808937-A1.; Title: strong similarity to 1,3-beta-glucanosyltransferase gel1 - Aspergillus fumigatus; See PMID 10769178; See PMID 10809732; uncharacterized protein 93864 4990293 An10g00400 Aspergillus niger uncharacterized protein XP_001402433.1 92418 R 5061 CDS An10g00410 4990294 join(98603..98839,99643..100300,100387..100811,101261..101343,101388..101925) V 1 NT_166537.1 Title: weak similarity to UDP-N-acetylglucosamine:alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV - Homo sapiens; uncharacterized protein 101925 4990294 An10g00410 Aspergillus niger uncharacterized protein XP_059605860.1 98603 D 5061 CDS An10g00420 84592102 102261..103073 V 1 NT_166537.1 Title: weak similarity to 2-5A-dependent ribonuclease RNS4 - Homo sapiens; uncharacterized protein 103073 84592102 An10g00420 Aspergillus niger uncharacterized protein XP_059605861.1 102261 D 5061 CDS An10g00425 84592103 complement(103533..103793) V 1 NT_166537.1 hypothetical protein 103793 84592103 An10g00425 Aspergillus niger hypothetical protein XP_059605862.1 103533 R 5061 CDS An10g00430 84592104 105539..106435 V 1 NT_166537.1 Complex: S. cerevisiae cell adhesion protein a-agglutinin is composed of an anchorage subunit (Aga1p) and an adhesion subunit (Aga2p).; Function: mating type-specific agglutination of S. cerevisiae a and alpha cells depends on the heterophilic interaction of two cell surface glycoproteins, the gene products of AG alpha 1 and AGA2.; Remark: truncated ORF due to the contig end.; Similarity: the BLASTp matches are mainly due to the serine-rich motif.; Title: strong similarity to agglutinin core protein Aga1 - Saccharomyces cerevisiae [truncated ORF]; cell wall; See PMID 2072914; See PMID 7770047; See PMID 7957044; uncharacterized protein 106435 84592104 An10g00430 Aspergillus niger uncharacterized protein XP_059605863.1 105539 D 5061 CDS An10g00440 4990299 join(108128..108765,108835..109369) V 1 NT_166537.1 Function: Nth-Spo possesses glycosylase activity on different types of DNA substrates with pyrimidine damage,being able to release both urea and thymine glycol from double-stranded polymers.; Remark: nth1 and SPAC30D11. 07 are alternative names for the nth-Spo gene; Title: strong similarity to endonuclease III nth-Spo - Schizosaccharomyces pombe; See PMID 8811082; uncharacterized protein 109369 4990299 An10g00440 Aspergillus niger uncharacterized protein XP_059599553.1 108128 D 5061 CDS An10g00450 84592105 109729..111225 V 1 NT_166537.1 hypothetical protein 111225 84592105 An10g00450 Aspergillus niger hypothetical protein XP_059599554.1 109729 D 5061 CDS An10g00460 4990300 join(112241..112794,112870..112902,112951..114383,114425..114491,114565..114649) V 1 NT_166537.1 Function: Smubp-2 DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence related to the immunoglobulin mu chain switch region.; Function: Smubp-2 preferentially binds to the motif (5'-gggct-3'). stimulates the transcription of the human neurotropic virus JVC.; Remark: glial factor-1, gf-1 and DNA helicase are alternative names for Smubp-2.; Remark: the ORF encoded protein also shows strong similarity to several helicases and nonsense-mediated RNA decay.; Similarity: Smubp-2 belongs to the DNA2/NAM7 helicase family.; Title: strong similarity to Ig mu chain switch region binding protein 2 Smubp-2 - Homo sapiens; nucleus; See PMID 8349627; See PMID 10049831; uncharacterized protein 114649 4990300 An10g00460 Aspergillus niger uncharacterized protein XP_059599555.1 112241 D 5061 CDS An10g00470 4990301 117078..118433 V 1 NT_166537.1 Title: weak similarity to hypothetical extensin-like protein - Arabidopsis thaliana; uncharacterized protein 118433 4990301 An10g00470 Aspergillus niger uncharacterized protein XP_001402441.3 117078 D 5061 CDS An10g00480 4990302 complement(join(118818..118962,119175..119326,119406..119888)) V 1 NT_166537.1 Title: similarity to hypothetical GPI-anchor biosynthesis protein PIG-F related protein CAD70892.1 -Neurospora crassa; uncharacterized protein 119888 4990302 An10g00480 Aspergillus niger uncharacterized protein XP_059601491.1 118818 R 5061 CDS An10g00490 4990303 complement(join(120368..123033,123090..123242,123442..123604)) V 1 NT_166537.1 Title: similarity to hypothetical RhoGAP GTPase activating protein - Schizosaccharomyces pombe; uncharacterized protein 123604 4990303 An10g00490 Aspergillus niger uncharacterized protein XP_059601492.1 120368 R 5061 CDS An10g00500 4990304 join(126946..126953,127020..127089,127271..127459) V 1 NT_166537.1 Title: strong similarity to essential protein SEQ ID NO:7288 from patent WO200253728-A2 - Candida albicans; uncharacterized protein 127459 4990304 An10g00500 Aspergillus niger uncharacterized protein XP_001402444.1 126946 D 5061 CDS An10g00510 4990305 join(128649..128669,128737..128751,128811..128925,128976..129111,129160..129797,129849..130063) V 1 NT_166537.1 Catalytic activity: as ADH catalyzes the oxidation of primary and secondary alcohols to aldehydes and ketones,respectively, by NAD+; as FDH catalyzes the oxidation by NAD+ of formaldehyde and glutathione to S-formylglutathione.; Function: SFA1 is responsible for resistance to formaldehyde in S. cerevisiae.; Remark: belongs to the class III alcohol dehydrogenases which are not very active toward ethanol.; Title: strong similarity to alcohol dehydrogenase Sfa1 - Saccharomyces cerevisiae; See PMID 8483449; uncharacterized protein 130063 4990305 An10g00510 Aspergillus niger uncharacterized protein XP_001402445.1 128649 D 5061 CDS An10g00520 84592106 130754..>131009 V 1 NT_166537.1 Function: ACC deaminase degrades ACC to 2-oxobutyrate and ammonia.; Remark: C-terminally truncated due to contig border.; Title: strong similarity to 1-aminocyclopropane-1-carboxylate (ACC) deaminase ACD -Penicillium citrinum [truncated ORF]; See PMID 10737185; uncharacterized protein 131009 84592106 An10g00520 Aspergillus niger uncharacterized protein XP_059601493.1 130754 D 5061 CDS An10g00530 4990307 complement(join(131399..132296,132344..133047)) V 1 NT_166537.1 Catalytic activity: D-glucose 6-phosphate <=> 1L-myo-inositol 1-phosphate.; Pathway: the myo-inositol-1-phosphate synthase from Arabidopsis thaliana is involved in the synthesis of the important membrane component phosphatidyl-inositol (PI).; Title: strong similarity to myo-inositol-1-phosphate synthase INO1 - Arabidopsis thaliana; See PMID 8058832; uncharacterized protein 133047 4990307 An10g00530 Aspergillus niger uncharacterized protein XP_001402447.1 131399 R 5061 CDS An10g00540 4990308 join(137028..137127,137162..137350,137418..139543) V 1 NT_166537.1 Complex: the human hic-5 protein forms a complex with the cell adhesion kinase beta (CAKbeta/PYK2), which is the second protein-tyrosine kinase of the focal adhesion kinase subfamily.; Title: similarity to protein Hic-5 - Homo sapiens; See PMID 9422762; uncharacterized protein 139543 4990308 An10g00540 Aspergillus niger uncharacterized protein XP_059601494.1 137028 D 5061 CDS An10g00550 84592107 complement(join(140449..141799,141841..141905)) V 1 NT_166537.1 hypothetical protein 141905 84592107 An10g00550 Aspergillus niger hypothetical protein XP_059601495.1 140449 R 5061 CDS An10g00560 4990310 142596..142871 V 1 NT_166537.1 Induction: the mRNA of the Aspergillus nidulans hypothetical protein BinA is induced by bafilomycin.; Title: strong similarity to hypothetical protein binA - Aspergillus nidulans; See PMID 10376827; uncharacterized protein 142871 4990310 An10g00560 Aspergillus niger uncharacterized protein XP_001402450.3 142596 D 5061 CDS An10g00570 4990311 complement(join(142924..143393,143468..143935,144009..144153)) V 1 NT_166537.1 Remark: the ADH sequence 19 protein is part of the patent EP0845532 with the title: 'Enzymes for the synthesis of coniferyl alcohol, coniferyl aldehyde, ferulic acid,vanillin, vanillic acid and their applications'.; Remark: the organism of patent EP0845532 remains unclassified.; Title: strong similarity to alcohol dehydrogenase ADH from patent EP0845532 - Unclassified organism; uncharacterized protein 144153 4990311 An10g00570 Aspergillus niger uncharacterized protein XP_001402451.1 142924 R 5061 CDS An10g00580 84592108 join(144375..144564,144614..144661,144778..144819,144861..144880) V 1 NT_166537.1 hypothetical protein 144880 84592108 An10g00580 Aspergillus niger hypothetical protein XP_059601496.1 144375 D 5061 CDS An10g00590 84592109 complement(145062..145940) V 1 NT_166537.1 Remark: the KLP2 (=kinesin-like protein) protein from X. laevis is localized on centrosomes throughout the cell cycle and on spindle pole microtubules during metaphase.; Similarity: the ORF encoded protein shows a weak similarity to KLP2 (X. n.) with an e-val. of 0. 059.; Title: weak similarity to protein KLP2 - Xenopus laevis; See PMID 8548825; uncharacterized protein 145940 84592109 An10g00590 Aspergillus niger uncharacterized protein XP_059601497.1 145062 R 5061 CDS An10g00600 4990314 join(146398..147916,147978..149133,149179..149518) V 1 NT_166537.1 Title: similarity to polypeptide SEQ ID NO:1833 from patent WO200171042-A2 - Drosophila melanogaster; uncharacterized protein 149518 4990314 An10g00600 Aspergillus niger uncharacterized protein XP_059601498.1 146398 D 5061 CDS An10g00610 84592110 join(150307..150485,150594..150780) V 1 NT_166537.1 hypothetical protein 150780 84592110 An10g00610 Aspergillus niger hypothetical protein XP_059601499.1 150307 D 5061 CDS An10g00620 4990316 join(152396..152439,152543..152636,152745..152874,152924..152950,153015..153634,153710..153964) V 1 NT_166537.1 Remark: the ToxF gene product from Cochliobolus carbonum is involved in production of the cyclic tetrapeptide HC-toxin, which is required for pathogenicity of the filamentous fungus Cochliobolus carbonum on maize.; Title: strong similarity to hypothetical branched-chain amino acid aminotransferase ToxF -Cochliobolus carbonum; See PMID 10627051; uncharacterized protein 153964 4990316 An10g00620 Aspergillus niger uncharacterized protein XP_059601500.1 152396 D 5061 CDS An10g00630 4990317 join(155339..155388,155462..155946,156007..160313) V 1 NT_166537.1 Catalytic activity: Acetyl-CoA+N malonyl-CoA+2N NADPH<=>a long-chain fatty acid+(N+1) CoA+N CO(2)+2N NADP(+).; Title: strong similarity to alpha subunit of the fatty acid synthase fasA - Aspergillus nidulans; See PMID 8848053; See PMID 8962148; uncharacterized protein 160313 4990317 An10g00630 Aspergillus niger uncharacterized protein XP_001402457.3 155339 D 5061 CDS An10g00640 84592111 complement(join(160997..161170,161314..161382)) V 1 NT_166537.1 hypothetical protein 161382 84592111 An10g00640 Aspergillus niger hypothetical protein XP_059601501.1 160997 R 5061 CDS An10g00650 4990319 join(161824..161850,161922..162013,162142..167249,167290..167900,167986..168387,168652..168705) V 1 NT_166537.1 Catalytic activity: Acetyl-CoA+N malonyl-CoA+2N NADPH<=>a long-chain fatty acid+(N+1) CoA+N CO(2)+2N NADP(+).; Title: strong similarity to fatty acid synthase beta subunit fasB - Aspergillus nidulans; See PMID 8848053; See PMID 8962148; uncharacterized protein 168705 4990319 An10g00650 Aspergillus niger uncharacterized protein XP_059601502.1 161824 D 5061 CDS An10g00660 4990320 join(170179..170253,170314..170464,170535..170867,170933..171951) V 1 NT_166537.1 Pathway: the TRI11 gene product from F. sporotrichioides is involved in the trichothecene biosynthesis. Trichothecenes are sesquiterpenoid toxins that act by inhibiting protein biosynthesis.; Remark: disruption of gene from Fusarium sporotrichioides results in an altered trichothecene production phenotype characterized by the accumulation of isotrichodermin, a trichothecene pathway intermediate.; Similarity: the TRI11 gene product from F. sporotrichioides belongs to the cytochrome p450 family.; Title: strong similarity to cytochrome P450 monooxygenase TRI11 - Fusarium sporotrichioides; See PMID 9435078; uncharacterized protein 171951 4990320 An10g00660 Aspergillus niger uncharacterized protein XP_001402460.1 170179 D 5061 CDS An10g00670 84592112 complement(join(172320..172368,172480..172921,172976..173075,173152..173535)) V 1 NT_166537.1 Title: similarity to hypothetical protein YER175c -Saccharomyces cerevisiae; uncharacterized protein 173535 84592112 An10g00670 Aspergillus niger uncharacterized protein XP_059601503.1 172320 R 5061 CDS An10g00680 10098287 join(175591..175632,175746..175875,175938..176094,176161..176264,176419..176570) V 1 NT_166537.1 Catalytic activity: ATP+H(2)O<=>ADP+phosphate.; Function: the S. cerevisiae Cup5 protein is a proton-conducting pore forming subunit of the membrane integral V0 complex of the vacuolar ATPase. The v-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. It is an electrogenic proton pump that generates a proton motive force of 180 mV,inside positive and acidic, in the vacuolar membrane vesicles.; Remark: alternative names for the S. cerevisiae CUP5 gene: VMA3,CLS7,GEF2 or YEL027W.; Title: strong similarity to H+-ATPase V0 domain 17 KD subunit Cup5 - Saccharomyces cerevisiae; See PMID 8246899; See PMID 1825730; uncharacterized protein 176570 10098287 An10g00680 Aspergillus niger uncharacterized protein XP_059601504.1 175591 D 5061 CDS An10g00690 4990323 complement(join(176862..178120,178170..178232,178281..178485)) V 1 NT_166537.1 Remark: the S. cerevisiae gene product Tna1(=YGR260w) belongs to the Dal5 transporter family.; Similarity: the ORF shows similarity to several putative allantoate transporters.; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563; uncharacterized protein 178485 4990323 An10g00690 Aspergillus niger uncharacterized protein XP_001402463.1 176862 R 5061 CDS An10g00700 4990324 join(181123..181195,181266..182200,182252..182845) V 1 NT_166537.1 Induction: the expression of the S. cerevisiae ATR1 gene is induced by the famous yeast transcriptional regulators Gcn4 and Yap1.; Remark: S. cervisiae Atr1=YML116W.; Title: strong similarity to aminotriazole resistance protein Atr1 - Saccharomyces cerevisiae; plasma membrane; See PMID 9287330; See PMID 3280970; uncharacterized protein 182845 4990324 An10g00700 Aspergillus niger uncharacterized protein XP_001402464.1 181123 D 5061 CDS An10g00710 4990325 complement(join(184149..185029,185082..185151)) V 1 NT_166537.1 Title: strong similarity to hypothetical protein B3E4.80 - Neurospora crassa; uncharacterized protein 185151 4990325 An10g00710 Aspergillus niger uncharacterized protein XP_059601505.1 184149 R 5061 CDS An10g00720 84592113 complement(join(186672..186692,186795..186827,186887..186954,187003..187129,187261..187383)) V 1 NT_166537.1 hypothetical protein 187383 84592113 An10g00720 Aspergillus niger hypothetical protein XP_059601506.1 186672 R 5061 CDS An10g00730 10098288 complement(join(188580..188899,188949..189352,189420..189703)) V 1 NT_166537.1 Catalytic activity: A nitrile + H(2)O <=> a carboxylate + NH(3); Remark: the aliphatic nitrilase from Rhodococcus rhodochrous K22 protein ID: BAA02127. 1.; Title: strong similarity to aliphatic nitrilase -Rhodococcus rhodochrous; See PMID 1390687; uncharacterized protein 189703 10098288 An10g00730 Aspergillus niger uncharacterized protein XP_003188804.2 188580 R 5061 CDS An10g00740 10098289 complement(join(190214..190352,190456..190816,190890..192965,193130..197537)) V 1 NT_166537.1 Similarity: the ORF encoding DNA sequence shows significant similarity to retrotransposons or retroviruses.; Title: strong similarity to retrotransposon Tto1 -Nicotiana tabacum; See PMID 8389699; See PMID 8522181; See PMID 8624443; uncharacterized protein 197537 10098289 An10g00740 Aspergillus niger uncharacterized protein XP_003188805.2 190214 R 5061 CDS An10g00780 4990329 201334..202932 V 1 NT_166537.1 Function: catalyzes hydrolysis of several beta-lactam antibiotic PNB esters to the corresponding free acid and PNB alcohol.; Title: strong similarity to p-nitrobenzyl esterase pnbA - Bacillus subtilis; See PMID 7828905; uncharacterized protein 202932 4990329 An10g00780 Aspergillus niger uncharacterized protein XP_001402469.3 201334 D 5061 CDS An10g00790 4990330 join(203191..203873,203950..203997,204129..204360,204390..204425) V 1 NT_166537.1 Title: similarity to hypothetical protein SCE6.29 -Streptomyces coelicolor; uncharacterized protein 204425 4990330 An10g00790 Aspergillus niger uncharacterized protein XP_059601507.1 203191 D 5061 CDS An10g00800 4990331 complement(join(204882..205952,206017..206169)) V 1 NT_166537.1 Function: the NUP nucleoside transporter from C. albicans is able to transport adenosine and guanosine, but not uridine, cytidine, adenine, guanine or uracil.; Title: strong similarity to purine nucleoside permease NUP - Candida albicans; See PMID 9802205; uncharacterized protein 206169 4990331 An10g00800 Aspergillus niger uncharacterized protein XP_001402471.1 204882 R 5061 CDS An10g00810 4990332 join(209297..209701,209779..210225) V 1 NT_166537.1 hypothetical protein 210225 4990332 An10g00810 Aspergillus niger hypothetical protein XP_001402472.3 209297 D 5061 CDS An10g00820 4990333 complement(join(211586..212208,212321..212468,212561..212689)) V 1 NT_166537.1 Catalytic activity: 1-carboxyvinyl carboxyphosphonat <=> 3-(hydrohydroxyphosphoryl)pyruvate + CO(2).; Function: the BcpA gene product from Streptomyces hygroscopicuscatalyzes the formation of an unusual C-P bond and is involved in the biosynthesis of the antibiotic Bialaphos (ba).; Similarity: the BcpA gene product from Streptomyces hygroscopicus belongs to the Isocitrate-Lyase family.; Title: strong similarity to carboxyphosphonoenolpyruvate phosphonomutase bcpA -Streptomyces hygroscopicus; See PMID 1330557; uncharacterized protein 212689 4990333 An10g00820 Aspergillus niger uncharacterized protein XP_001402473.3 211586 R 5061 CDS An10g00830 4990334 join(215615..215744,215869..216488) V 1 NT_166537.1 Similarity: the ORF encoded protein shows also weak similarity to the hypothetical protein SC7H1. 16 from Streptomyces coelicolor.; Title: strong similarity to hypothetical protein EAA60090.1 - Aspergillus nidulans; uncharacterized protein 216488 4990334 An10g00830 Aspergillus niger uncharacterized protein XP_001402474.1 215615 D 5061 CDS An10g00840 4990335 complement(join(216576..217316,217389..217550)) V 1 NT_166537.1 Title: weak similarity to hypothetical adenylate/guanylate cyclase cyaF3 - Sinorhizobium meliloti; uncharacterized protein 217550 4990335 An10g00840 Aspergillus niger uncharacterized protein XP_001402475.1 216576 R 5061 CDS An10g00850 4990336 join(218283..218328,218386..218839,218904..219609,219674..219970) V 1 NT_166537.1 Title: strong similarity to indole-3-acetaldehyde dehydrogenase Iad1 - Ustilago maydis; See PMID 9022693; uncharacterized protein 219970 4990336 An10g00850 Aspergillus niger uncharacterized protein XP_001402476.1 218283 D 5061 CDS An10g00860 4990337 complement(join(220102..220145,220245..220410,220484..220978,221050..221202,221260..221397)) V 1 NT_166537.1 Catalytic activity: Gibberellin 20 + 2-oxoglutarate + O(2) <=> gibberellin 1 + succinate + CO(2).; Cofactor: the giberellin 3beta-dioxygenase from P. sativum needs Iron and Ascorbate.; Similarity: the ORF encoded protein shows also similarity to patent W04560.; Title: similarity to giberellin 3beta-dioxygenase Ps074 - Pisum sativum; See PMID 8904804; uncharacterized protein 221397 4990337 An10g00860 Aspergillus niger uncharacterized protein XP_059601508.1 220102 R 5061 CDS An10g00870 4990338 join(223194..223301,223349..223575,223625..223710,223763..223848,223908..224372) V 1 NT_166537.1 Function: the A. niger plyA gene encodes pectate lyase A.; Gene-ID: plyA; Remark: plyA exists in an unmodified and in an N-glycosylated form with identical specific activities.; Remark: the matching sequence of plyA from A. niger was found by a BLAST search against the new EMBL entry CAC33162.; Similarity: the ORF encoded protein shows also strong similarity to Bacillus licheniformis Pectate lyase II from patent WO9927083-A1.; See PMID 11112543; pectate lyase plyA-Aspergillus niger 224372 plyA 4990338 plyA Aspergillus niger pectate lyase plyA-Aspergillus niger XP_001402478.1 223194 D 5061 CDS An10g00880 4990339 complement(join(225429..226584,226634..226810,226941..227079,227168..227362,227414..228074,228105..228179)) V 1 NT_166537.1 Function: the human monocarboxylate transporter 2 (hMCT2) catalyzes the H+/lactate-cotransport and facilitates the cellular uptake of lactate, pyruvate and other monocarboxylates. It participates in the CORI cycle by exporting lactate from the intestine and the erythrocytes.; Remark: the ORF encoded protein is n-terminal extended in comparison to its homologues.; Similarity: the ORF encoded protein shows also similarity to the human patent WO9941373-A2.; Title: similarity to monocarboxylate transporter 2 hMCT2 - Homo sapiens; See PMID 9786900; uncharacterized protein 228179 4990339 An10g00880 Aspergillus niger uncharacterized protein XP_001402479.3 225429 R 5061 CDS An10g00890 84592114 join(228625..228659,229147..229177,229418..229590,229624..231781) V 1 NT_166537.1 Title: strong similarity to ankyrin Ank3 - Mus musculus; See PMID 7615634; uncharacterized protein 231781 84592114 An10g00890 Aspergillus niger uncharacterized protein XP_059601509.1 228625 D 5061 CDS An10g00900 4990341 join(232199..232923,233034..233340) V 1 NT_166537.1 Function: the protein (patent WO9710341-A1) from Fusarium oxysporum shows a natural D-pantolactone hydrolase activity.; Similarity: the published lactonase from Fusarium oxysporum (PubMed 1396712) is identical to the protein from patent WO9710341-A1.; Title: strong similarity to D-pantolactone hydrolase from patent WO9710341-A1 - Fusarium oxysporum; See PMID 1396712; uncharacterized protein 233340 4990341 An10g00900 Aspergillus niger uncharacterized protein XP_001402481.1 232199 D 5061 CDS An10g00910 4990342 join(234580..235788,235882..236199) V 1 NT_166537.1 Catalytic activity: digallate + H(2)O <=> 2 gallate.; Similarity: the tannase from Aspergillus oryzae (PubMed 9146733 and 8917102) is identical to patent JP08080196-A.; Title: strong similarity to precursor of tannase -Aspergillus oryzae; See PMID 8917102; See PMID 9146733; uncharacterized protein 236199 4990342 An10g00910 Aspergillus niger uncharacterized protein XP_001402482.1 234580 D 5061 CDS An10g00920 84592115 join(237803..237937,237998..238068,238200..238242) V 1 NT_166537.1 Title: weak similarity to hypothetical protein encoded by An12g10350 - Aspergillus niger; uncharacterized protein 238242 84592115 An10g00920 Aspergillus niger uncharacterized protein XP_059601510.1 237803 D 5061 CDS An10g00930 84592116 complement(join(239861..239998,240167..240235,240328..240386,240906..240963,241069..241140)) V 1 NT_166537.1 Remark: the ORF has an unusual exon/intron structure for A. niger.; Title: questionable ORF; uncharacterized protein 241140 84592116 An10g00930 Aspergillus niger uncharacterized protein XP_059601511.1 239861 R 5061 CDS An10g00940 84592117 join(241835..241855,241940..242022,242248..242301,242373..242424,242615..242753,242841..242930,242974..243091,243138..243219) V 1 NT_166537.1 Remark: the ORF has an unusual exon/intron structure for A. niger.; hypothetical protein 243219 84592117 An10g00940 Aspergillus niger hypothetical protein XP_059601512.1 241835 D 5061 CDS An10g00950 4990346 243683..245428 V 1 NT_166537.1 Catalytic activity: digallate + H2O = 2 gallate.; Function: the acylhydrolase tannase of A. oryzae hydrolyzes the ester bonds of tannic acid to produce gallic acid and glucose.; Remark: tannase of A. oryzae can be used as a processing aid for the manufacture of cold water-soluble tea beverages and for clarification in beer production.; Remark: tannins have a wide range of effects on various organisms - from toxic effects on animals to growth inhibition of microorganisms.; Title: strong similarity to tannase precursor from patent JP08080196-A - Aspergillus oryzae; See PMID 8917102; See PMID 9146733; uncharacterized protein 245428 4990346 An10g00950 Aspergillus niger uncharacterized protein XP_001402486.1 243683 D 5061 CDS An10g00960 84592118 complement(join(245851..245931,246044..246166,246232..246261,246324..246383,246433..246687,246745..247144,247199..248637)) V 1 NT_166537.1 Function: inversin of M. musculus is responsible for left-right body axis determination.; Phenotype: the transgenic inv mouse (recessive deletion of the inversin gene) displays situs inversus and jaundice ('yellowing' by bilirubin, e. g. due to a liver problem).; Similarity: the ORF is much shorter than inversin of M. musculus (795 compared to 1062 amino acids).; Similarity: the ORF shows local similarity to inversin of M. musculus along a N-terminal stretch of about 200 amino acids.; Title: weak similarity to left-right axis pathway protein inversin invs - Mus musculus; See PMID 9771707; See PMID 10421642; uncharacterized protein 248637 84592118 An10g00960 Aspergillus niger uncharacterized protein XP_059601513.1 245851 R 5061 CDS An10g00970 4990348 complement(join(249553..249713,249774..249926,249985..250067,250146..250408)) V 1 NT_166537.1 Remark: the DNA sequence of the ORF shows similarity to a part of the A. oryzae EST from patent WO200056762-A2.; Title: strong similarity to hypothetical protein encoded by An03g01670 - Aspergillus niger; uncharacterized protein 250408 4990348 An10g00970 Aspergillus niger uncharacterized protein XP_059601514.1 249553 R 5061 CDS An10g00980 84592119 join(250518..250606,250685..250852,251142..251251,251523..251662) V 1 NT_166537.1 Remark: the ORF has an unusual exon/intron structure for A. niger.; hypothetical protein 251662 84592119 An10g00980 Aspergillus niger hypothetical protein XP_059601515.1 250518 D 5061 CDS An10g01000 4990351 join(254656..254755,254802..255042,255091..255362,255420..255583) V 1 NT_166537.1 Function: cpo of L. fumago catalyzes the peroxidative chlorination of organic acceptor molecules: 2 RH + 2 Cl- + H2O2 = 2 RCl + 2 H2O.; Induction: fructose induces mRNA and protein production of cpo of L. fumago, whereas glucose represses mRNA and protein production.; Remark: Leptoxyphium fumago is also called Caldariomyces fumago.; Title: similarity to chloride peroxidase cpo -Leptoxyphium fumago; See PMID 11278701; See PMID 3771564; uncharacterized protein 255583 4990351 An10g01000 Aspergillus niger uncharacterized protein XP_001402490.1 254656 D 5061 CDS An10g01010 4990352 complement(join(256024..256476,256533..256952,257004..257036)) V 1 NT_166537.1 Catalytic activity: cp100 of S. tuberosum catalyzes the reversible oxidation of vestitone to 2'-hydroxyformononetin.; Induction: expression of cp100 in the pistils of S. tuberosum is enhanced after pollination.; Remark: cp100 of S. tuberosum belongs to the 2'-hydroxyisoflavone reductase superfamily.; Similarity: about 75 C-terminal amino acids are not encompassed by the alignment between the ORF and S. tuberosum.; Title: similarity to 2-hydroxyisoflavone reductase cp100 - Solanum tuberosum; See PMID 9106515; uncharacterized protein 257036 4990352 An10g01010 Aspergillus niger uncharacterized protein XP_001402491.1 256024 R 5061 CDS An10g01020 4990353 join(257436..258115,258160..258250,258299..259345) V 1 NT_166537.1 Function: amyR of A. nidulans encodes a transcriptional activator for the amylase genes.; Phenotype: disruption of amyR of A. nidulans caused defects in the utilization of maltose and starch.; Remark: amyR of A. nidulans belongs to the GAL4 family of transcription factors.; Repression: expression of amyR of A. nidulans is regulated by the carbon catabolite repressor CREA.; Similarity: the ORF shows local (N-terminal) similarity to amyR of A. nidulans.; Title: similarity to transcription regulator of maltose utilization amyR - Aspergillus nidulans; nucleus; See PMID 11318101; uncharacterized protein 259345 4990353 An10g01020 Aspergillus niger uncharacterized protein XP_059601516.1 257436 D 5061 CDS An10g01030 84592120 join(259396..259554,259616..259861) V 1 NT_166537.1 Function: HGT1 of K. lactis is a high-affinity glucose transporter.; Phenotype: disruption of HGT1 of K. lactis leads to reduced glucose uptake and reduced growth in low-glucose medium.; Remark: HGT1 of K. lactis belongs to the sugar transporter family.; Similarity: the ORF is shorter than HGT1 of K. lactis (154 compared to 551 amino acids).; Similarity: the ORF shows only local similarity (over a stretch of ca. 100 amino acids) to HGT1 of K. lactis.; Title: similarity to high-affinity glucose transporter HGT1 - Kluyveromyces lactis; See PMID 8830679; uncharacterized protein 259861 84592120 An10g01030 Aspergillus niger uncharacterized protein XP_059601517.1 259396 D 5061 CDS An10g01040 4990355 join(260442..260708,260759..261103) V 1 NT_166537.1 Title: strong similarity to hypothetical IgE-binding protein - Aspergillus fumigatus; uncharacterized protein 261103 4990355 An10g01040 Aspergillus niger uncharacterized protein XP_001402494.1 260442 D 5061 CDS An10g01050 84592121 complement(join(261397..261556,261638..261764,261819..261878,261921..262026,262105..262143)) V 1 NT_166537.1 hypothetical protein 262143 84592121 An10g01050 Aspergillus niger hypothetical protein XP_059601518.1 261397 R 5061 CDS An10g01060 84592122 join(262267..262341,262424..262512,262624..262642) V 1 NT_166537.1 hypothetical protein 262642 84592122 An10g01060 Aspergillus niger hypothetical protein XP_059601519.1 262267 D 5061 CDS An10g01070 84592123 complement(263097..>263333) V 1 NT_166537.1 Remark: N-terminal truncated ORF due to end of contig.; hypothetical protein [truncated ORF] 263333 84592123 An10g01070 Aspergillus niger hypothetical protein [truncated ORF] XP_059601520.1 263097 R 5061 CDS An16g00010 4988416 complement(609..1760) V 1 NT_166531.1 Function: the patented alcohol dehydrogenase has at least one of the following enzymatic activities: (a) acetaldehyde dehydrogenase (ACDH) activity whereby acetyl CoA is converted into acetaldehyde; (b) alcohol dehydrogenase (ADH) activity whereby acetaldehyde is converted into ethanol; (c) the capability to convert acetyl CoA into ethanol; and (d) pyruvate formate-lyase (pfl) deactivase activity.; Remark: lactic acid bacteria containing the DNA sequence can be used for producing food products or animal feed, which have increased amounts of metabolites such as acetaldehyde, ethanol, formate, acetate, alpha-acetolactate, acetoin, diacetyl or 2,3 butylene glycol. the food products have improved flavour or improved shelf life due to the enhanced production of antimicrobially active metabolites.; Similarity: the predicted A. niger protein shows similarity to alcohol dehydrogenase of patent WO9807867-A2 from L. lactis (AC# AAW53944).; Title: similarity to alcohol dehydrogenase orfB from patent WO9807867-A2 - Lactococcus lactis; uncharacterized protein 1760 4988416 An16g00010 Aspergillus niger uncharacterized protein XP_001397315.1 609 R 5061 CDS An16g00020 4988431 join(2211..2414,2474..2744,2796..2963,3025..3302,3356..3706,3755..3949) V 1 NT_166531.1 Function: Agt1p of S. cerevisiae is a high-affinity,maltose/proton symporter capable of transporting maltose,turanose, isomaltose, alpha-methylglucoside, maltotriose,palatinose, trehalose and melezitose.; Induction: AGT1 expression is maltose inducible and induction is mediated by the Mal-activator.; Similarity: the predicted A. niger protein shows strong similarity to the alpha-glucoside transport protein (AGT1) of S. cerevisiae which belongs to the maltose transport protein family.; Title: strong similarity to alpha-glucoside-hydrogen symporter Mal11 - Saccharomyces cerevisiae; plasma membrane; See PMID 8594329; uncharacterized protein 3949 4988431 An16g00020 Aspergillus niger uncharacterized protein XP_059602657.1 2211 D 5061 CDS An16g00030 4988399 complement(join(4793..5987,6087..6523)) V 1 NT_166531.1 Catalytic activity: cholinesterase 2 (ChE2) from B. floridae hydrolyses an acylcholine + H(2)O <=> choline + a carboxylic acid anion.; Inhibition: cholinesterase 2 (ChE2) from B. floridae is inhibited by BW284c51.; Localization: in vivo, the vast majority of ChE2 is localized in membranes as ethanolamine-glycan-phosphatidylinositol-anchored G2 forms.; Similarity: the predicted A. niger protein shows strong similarity to cholinesterase 2 (ChE2) from B. floridae and to other hydrolases which act on ester bonds.; Title: strong similarity to cholinesterase 2 ChE2 -Branchiostoma floridae; plasma membrane; See PMID 9874207; uncharacterized protein 6523 4988399 An16g00030 Aspergillus niger uncharacterized protein XP_059602658.1 4793 R 5061 CDS An16g00040 4988423 join(6797..6800,6912..7040,7111..9091,9248..9329,9405..9512,9591..9746,9812..9937) V 1 NT_166531.1 Remark: the CZF1 gene, encoding a putative transcription factor, was shown to be involved in the regulation of hyphal growth under certain conditions,including embedded conditions. ectopic expression of CZF1 in embedded cells promoted the rapid formation of hyphae. elimination of CZF1 and CPH1, encoding a homologue of the S. cerevisiae Ste12p transcription factor, led to a pronounced defect in filamentous growth of embedded cells.; Similarity: contains a Zn(2)-Cys(6), fungal-type binuclear cluster domain.; Title: similarity to zinc-finger protein CZF1 -Candida albicans; See PMID 10564506; See PMID 1409649; uncharacterized protein 9937 4988423 An16g00040 Aspergillus niger uncharacterized protein XP_059602659.1 6797 D 5061 CDS An16g00050 4988410 join(10607..10901,10973..10994,11065..11203,11276..11363,11424..11611,11665..11828,11904..12017,12258..12707,12819..12940,13063..13292) V 1 NT_166531.1 Remark: the patent does not provide further information about the function of the protein.; Similarity: the predicted A. niger protein shows strong similarity to sequence 253 from patent WO0100804-A/253 of C. glutamicum (AC# AX066349) and to many putative multidrug-efflux transporters.; Title: strong similarity to sequence 253 from patent WO0100804 - Corynebacterium glutamicum; uncharacterized protein 13292 4988410 An16g00050 Aspergillus niger uncharacterized protein XP_059602660.1 10607 D 5061 CDS An16g00060 84593287 complement(join(13782..14196,14250..14401,14473..14789,14850..14904)) V 1 NT_166531.1 Remark: MesA of P. multocida confers a hemolytic phenotype in E. coli under anaerobic conditions.; Similarity: the predicted A. niger protein shows similarity to esterase MesA of P. multocida; Title: similarity to esterase mesA - Pasteurella multocida; See PMID 11064203; uncharacterized protein 14904 84593287 An16g00060 Aspergillus niger uncharacterized protein XP_059602661.1 13782 R 5061 CDS An16g00070 4988404 complement(15651..17036) V 1 NT_166531.1 Similarity: the nucleotide sequence of the ORF shows strong similarity to the EST an_2627 of A. niger (AC# BE759725).; Title: strong similarity to EST an_2627 -Aspergillus niger; uncharacterized protein 17036 4988404 An16g00070 Aspergillus niger uncharacterized protein XP_001397321.1 15651 R 5061 CDS An16g00080 84593288 join(17443..17548,17625..17667,17820..17876,17965..18156,18245..18396,18508..18685,18778..18787,18879..19020,19096..19298,19365..19455,19539..19600) V 1 NT_166531.1 hypothetical protein 19600 84593288 An16g00080 Aspergillus niger hypothetical protein XP_059602662.1 17443 D 5061 CDS An16g00090 4988396 join(21796..21989,22074..22530,22595..23419) V 1 NT_166531.1 Function: FLU1 of C. albicans facilitates resistance to fluconazole and cycloheximide in the fluconazole-hypersensitive S. cerevisiae strain YKKB-13 lacking the ABC (ATP-binding cassette) transporter gene PDR5.; Function: FLU1 of C. albicans facilitates resistance to mycophenolic acid in C. albicans.; Function: FLU1 of C. albicans is involved in the resistance to azol derivatives in C. albicans.; Function: MDR1 of C. albicans facilitates resistance to the anti-mitotic drug benomyl and to the dihydrofolate reductase inhibitor methotrexate.; Similarity: N-terminus of the A. niger protein is app. 120 aa shorter than in FLU1 of C. albicans.; Similarity: the predicted A. niger protein shows strong similarity to fluconazole resistance protein FLU1of C. albicans, which is a permease belonging to the major facilitator superfamily.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353; uncharacterized protein 23419 4988396 An16g00090 Aspergillus niger uncharacterized protein XP_001397323.1 21796 D 5061 CDS An16g00100 84593289 join(23533..23646,23754..23831,23922..24199,24290..24359,24450..24593) V 1 NT_166531.1 hypothetical protein 24593 84593289 An16g00100 Aspergillus niger hypothetical protein XP_059602663.1 23533 D 5061 CDS An16g00110 4988412 join(25047..25141,25221..25730,25807..26074) V 1 NT_166531.1 Catalytic activity: EC 4. 1. 2. 13 catalyses the reversible cleavage of fructose-1,6-bisphosphate to dihydroxyacetone phosphate and glyceraldehyde-3-phosphate.; Complex: fructose-1,6-bisphosphate aldolase of T. aquaticus forms a homotetramer.; Pathway: EC 4. 1. 2. 13 is an enzyme of the glycolysis and gluconeogenesis pathways.; Title: strong similarity to fructose-1,6-bisphosphate aldolase - Thermus aquaticus; cytoplasm; See PMID 8898912; See PMID 11173490; See PMID 11237691; uncharacterized protein 26074 4988412 An16g00110 Aspergillus niger uncharacterized protein XP_001397325.1 25047 D 5061 CDS An16g00120 4988398 complement(join(27241..28182,28234..28380)) V 1 NT_166531.1 Catalytic activity: (S)-malate + NAD+ = oxaloacetate + NADH.; Pathway: citrate cycle (TCA cycle); pyruvate metabolism; glyoxylate and dicarboxylate metabolism; reductive carboxylate cycle (CO2 fixation).; Remark: the MDH enzyme from Methanothermus fervidus is a homomeric dimer with a molecular mass of 70 kDa,possesses low specificity for NAD+ or NADP+ and catalyzes preferentially the reduction of oxalacetate.; Similarity: belongs to the malate dehydrogenase ylbC family.; Title: strong similarity to L-malate dehydrogenase MDH - Methanothermus fervidus; See PMID 2110059; uncharacterized protein 28380 4988398 An16g00120 Aspergillus niger uncharacterized protein XP_001397326.1 27241 R 5061 CDS An16g00130 4988424 join(29592..29786,29852..30125,30176..30960,31034..31291) V 1 NT_166531.1 Remark: hpaA gene forms a transcriptional unit with the hpaX transport gene.; Remark: hpaX in E. coli is a transport gene for an aromatic compound (4-hydroxyphenylacetate) of enteric bacteria.; Title: strong similarity to 4-hydroxyphenylacetate permease hpaX - Escherichia coli; See PMID 9126350; See PMID 9315705; uncharacterized protein 31291 4988424 An16g00130 Aspergillus niger uncharacterized protein XP_001397327.1 29592 D 5061 CDS An16g00140 4988425 complement(join(31608..31889,31989..32159,32230..32400,32476..32538)) V 1 NT_166531.1 Catalytic activity: cephalosporin C + H2O = deacetylcephalosporin C + acetate.; Remark: acyI Pseudomonas sp. converts cephalosporin C and 7 beta-(4-carboxybutanamido)cephalosporanic acid (GL-7ACA) to 7-aminocephalosporanic acid (7ACA).; Title: similarity to cephalosporin acylase acyI -Pseudomonas sp.; See PMID 2824449; See PMID 1358202; uncharacterized protein 32538 4988425 An16g00140 Aspergillus niger uncharacterized protein XP_001397328.1 31608 R 5061 CDS An16g00150 4988420 complement(join(32859..34003,34057..34967,35022..35257)) V 1 NT_166531.1 Remark: the uaY gene codes for a transcriptional activator mediating the induction of a number of unlinked genes involved in purine utilization in Aspergillus nidulans.; Similarity: belongs to the unassigned GAL4-type zinc cluster protein family.; Title: similarity to positive regulator of purine utilisation uaY - Aspergillus nidulans; See PMID 7729421; uncharacterized protein 35257 4988420 An16g00150 Aspergillus niger uncharacterized protein XP_001397329.3 32859 R 5061 CDS An16g00160 4988421 join(35870..35892,35933..35988,36053..36747) V 1 NT_166531.1 Catalytic activity: 2-pyrone-4,6-dicarboxylate + H2O = 4-carboxy-2-hydroxyhexa-2,4-dienedioate.; Pathway: Protocatechuate 4,5-cleavage pathway/phenylalanine metabolism.; Remark: LigI activity was inhibited by the addition of thiol reagents, suggesting that the cysteine residue is a catalytic site. LigI is more resistant to metal ion inhibition than the PDC hydrolases of Pseudomonas ochraceae.; Title: strong similarity to 2-pyrone-4,6-dicarboxylic acid hydrolase LigI - Sphingomonas paucimobilis; See PMID 9864312; uncharacterized protein 36747 4988421 An16g00160 Aspergillus niger uncharacterized protein XP_059602664.1 35870 D 5061 CDS An16g00170 4988417 complement(join(37235..37393,37446..38278,38329..38467)) V 1 NT_166531.1 Function: D-alanine:D-alanine ligases are involved in the resistance to the antibiotic vancomycin, by catalysing the ester bound formation in the depsipeptide.; Title: weak similarity to D-alanine:D-alanine ligase-related protein DdlM - Streptomyces toyocaensis; See PMID 9177243; uncharacterized protein 38467 4988417 An16g00170 Aspergillus niger uncharacterized protein XP_001397331.1 37235 R 5061 CDS An16g00180 4988406 complement(join(39101..39546,39606..40147,40222..40322)) V 1 NT_166531.1 Catalytic activity: dTDPglucose = dTDP-4-dehydro-6-deoxy-D-glucose + H2O.; Pathway: nucleotide sugars metabolism; erythromycin biosynthesis.; Remark: also strong similarity to Salmonella enterica O antigen TDP-rhamnose pathway protein patent WO9850531-A1.; Remark: conserved genes like rmlB at the end of an O antigen gene cluster play a major role in mediating exchange of the central serogroup-specific regions in Salmonella enterica.; Similarity: belongs to the NAD dependent epimerase/dehydratase family.; Title: strong similarity to dTDP-D-glucose-4,6-dehydratase rmlB - Salmonella enterica; See PMID 10974117; uncharacterized protein 40322 4988406 An16g00180 Aspergillus niger uncharacterized protein XP_059602665.1 39101 R 5061 CDS An16g00190 84593290 complement(join(43126..43225,43273..43311,43348..43373,43552..44023,44057..44298)) V 1 NT_166531.1 hypothetical protein 44298 84593290 An16g00190 Aspergillus niger hypothetical protein XP_059602666.1 43126 R 5061 CDS An16g00200 4988408 complement(join(44529..44608,44680..45225,45282..45809,45949..46000)) V 1 NT_166531.1 Catalytic activity: trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH.; Remark: dimeric dihydrodiol dehydrogenases (DDs, EC 1. 3. 1. 20), which oxidize trans-dihydrodiols of aromatic hydrocarbons to the corresponding catechols, have been molecularly cloned from human intestine, monkey kidney, pig liver, dog liver, and rabbit lens.; Similarity: belongs to the dehydrogenase and related protein family.; Title: strong similarity to dimeric dihydrodiol dehydrogenase SUS2DD - Sus scrofa; See PMID 10477285; See PMID 11306093; uncharacterized protein 46000 4988408 An16g00200 Aspergillus niger uncharacterized protein XP_059602667.1 44529 R 5061 CDS An16g00210 4988402 46622..47821 V 1 NT_166531.1 Remark: wecE is one protein in E. coli which is responsible for synthesis of the enterobacterial common antigen (ECA), a glycolipid situated on the outer leaflet of the outer membrane of members of the family Enterobacteriaceae.; Title: strong similarity to hypothetical regulator wecE - Escherichia coli; See PMID 9811644; uncharacterized protein 47821 4988402 An16g00210 Aspergillus niger uncharacterized protein XP_001397335.1 46622 D 5061 CDS An16g00220 4988414 complement(48117..48791) V 1 NT_166531.1 hypothetical protein 48791 4988414 An16g00220 Aspergillus niger hypothetical protein XP_001397336.1 48117 R 5061 CDS An16g00230 4988418 join(50777..52651,52773..52815,52867..53084) V 1 NT_166531.1 Function: channel protein for glycerol. has a role in both glycerol influx and efflux. plays a role in osmoregulation: under osmotic stree the channel is apparently closed to allow accumulation of glycerol in the cell under hyperosmotic conditions.; Remark: Fps1 is a regulated yeast glycerol facilitator controlling glycerol production and cytosolic concentration, and might have additional functions.; Remark: the Orf has C-terminal similarity to the aquaporin protein family.; Similarity: belongs to the Major Intrinsic Protein Family.; Title: strong similarity to suppressor protein Fps1 - Saccharomyces cerevisiae; See PMID 7729414; See PMID 9401039; See PMID 10096077; uncharacterized protein 53084 4988418 An16g00230 Aspergillus niger uncharacterized protein XP_059602668.1 50777 D 5061 CDS An16g00240 4988409 53394..54548 V 1 NT_166531.1 Remark: transport assays revealed that the mae1 gene from fission yeast encodes a permease involved in the uptake of L-malate, succinate and malonic acid.; Title: strong similarity to C4-dicarboxylate transport protein mae1p - Schizosaccharomyces pombe; plasma membrane; See PMID 8750236; uncharacterized protein 54548 4988409 An16g00240 Aspergillus niger uncharacterized protein XP_001397338.3 53394 D 5061 CDS An16g00250 4988400 complement(join(54723..55121,55172..55555,55615..55756,55808..55947)) V 1 NT_166531.1 Function: required for transport of secretory proteins from the golgi complex. Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes in vitro. Essential for viability and secretion.; Remark: SEC14 is an essential gene for yeast vegetative growth and is required for export of yeast secretory proteins from the Golgi complex.; Similarity: belongs to the sec14 cytosolic factor family.; Title: strong similarity to cytosolic factor Sec14 -Saccharomyces cerevisiae; See PMID 2215682; See PMID 2466847; See PMID 9461221; uncharacterized protein 55947 4988400 An16g00250 Aspergillus niger uncharacterized protein XP_001397339.1 54723 R 5061 CDS An16g00260 4988411 join(57020..57296,57355..57401,57459..57706,57764..58394,58454..58608,58675..58940,59005..59071,59128..59296) V 1 NT_166531.1 Catalytic activity: EC: 2. 5. 1. 29: trans,trans-farnesyl diphosphate + isopentenyl diphosphate = pyrophosphate + geranylgeranyl diphosphate.; Catalytic activity: EC: 4. 1. 99. 7: trans,trans-farnesyl diphosphate <=> aristolochene + diphosphate.; Pathway: sterol biosynthesis; terpenoid biosynthesis.; RemarK: the rice pathogen, Gibberella fujikuroi,produces large amounts of gibberellins, a group of natural plant hormones, which induce the superelongation (bakanae) disease of rice. Gibberellins are diterpenoid compounds which are synthesized via the isoprenoid pathway.; Remark: N-terminal is a aristolochene synthase activity and C-terminal there is the geranylgeranyl diphosphate synthetase activity.; Remark: there are two different enzyme activities in this ORF, but we propose one ORF with differential splicing.; Title: similarity to geranylgeranyl diphosphate synthase GGSII - Gibberella fujikuroi; See PMID 8440737; See PMID 9230902; See PMID 9917370; uncharacterized protein 59296 4988411 An16g00260 Aspergillus niger uncharacterized protein XP_059602669.1 57020 D 5061 CDS An16g00270 84593291 join(59452..59574,59653..59685,59795..59884,59959..60106,60251..60315) V 1 NT_166531.1 hypothetical protein 60315 84593291 An16g00270 Aspergillus niger hypothetical protein XP_059602670.1 59452 D 5061 CDS An16g00280 84593292 join(60317..60607,60692..60743,61078..61397) V 1 NT_166531.1 hypothetical protein 61397 84593292 An16g00280 Aspergillus niger hypothetical protein XP_059602671.1 60317 D 5061 CDS An16g00290 4988427 61709..62983 V 1 NT_166531.1 Title: similarity to hypothetical protein CAD70538.1 - Neurospora crassa; uncharacterized protein 62983 4988427 An16g00290 Aspergillus niger uncharacterized protein XP_001397343.1 61709 D 5061 CDS An16g00300 4988405 complement(63310..64224) V 1 NT_166531.1 Catalytic activity: S-adenosyl-L-methionine + 5alpha-cholesta-8,24-dien-3beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5alpha-cholest-8-en-3beta-ol.; Remark: also strong similarity to corn (Zea mays) SMT enzyme WO9845457-A1.; Remark: the enzyme requires glutathione as cofactor.; Similarity: belongs to the SAM-dependent methyltransferase family.; Title: strong similarity to 24-sterol C-methyltransferase ESMT1 - Zea mays; See PMID 9290641; uncharacterized protein 64224 4988405 An16g00300 Aspergillus niger uncharacterized protein XP_001397344.1 63310 R 5061 CDS An16g00310 84593293 complement(join(64495..64818,64914..64996,65094..65202,65445..65489,65709..65762)) V 1 NT_166531.1 hypothetical protein 65762 84593293 An16g00310 Aspergillus niger hypothetical protein XP_059602672.1 64495 R 5061 CDS An16g00320 4988422 join(66040..66127,66174..66614,66678..66886) V 1 NT_166531.1 Remark: putative endoglucanase but due to the patent there are no more informations available.; Remark: strong similarity to Zea mays sequence 11 from patent WO0073470 found in TREMBL:AX053132_1.; Similarity: to dienelactone hydrolase and related enzymes.; Title: strong similarity to endoglucanase sequence 11 from patent WO0073470 - Zea mays; uncharacterized protein 66886 4988422 An16g00320 Aspergillus niger uncharacterized protein XP_001397346.1 66040 D 5061 CDS An16g00330 84593294 complement(join(67362..67477,67516..67609,67641..67772,67824..67859)) V 1 NT_166531.1 Title: weak similarity to C-terminal domain of heat shock protein groEL - Lactococcus lactis; uncharacterized protein 67859 84593294 An16g00330 Aspergillus niger uncharacterized protein XP_059602673.1 67362 R 5061 CDS An16g00340 84593295 complement(join(67999..68064,68168..68211,68349..68465,68521..68587)) V 1 NT_166531.1 hypothetical protein 68587 84593295 An16g00340 Aspergillus niger hypothetical protein XP_059602674.1 67999 R 5061 CDS An16g00350 4988426 complement(join(69234..69433,69501..69941,70007..70150,70211..70554,70613..70685,70756..70769,70864..71027)) V 1 NT_166531.1 Remark: strong similarity to N. crassa mtr gene product patent WO9521263-A1.; Remark: the gene product of the mtr locus of Neurospora crassa is required for the transport of neutral aliphatic and aromatic amino acids via the N system.; Title: strong similarity to neutral amino acid permease mtr - Neurospora crassa; See PMID 8001794; See PMID 1838345; uncharacterized protein 71027 4988426 An16g00350 Aspergillus niger uncharacterized protein XP_059602675.1 69234 R 5061 CDS An16g00360 84593296 complement(join(71118..71175,71336..71430,71502..71576,71657..71764,71818..71887,71928..72106,72198..72317,72410..72475,72516..72565,72649..72790)) V 1 NT_166531.1 Remark: weak similarity to human FAST-1 protein patent WO200002910-A2.; Title: weak similarity to forkhead activin signal transducer FAST-1 from patent WO200002910-A2 - Homo sapiens; uncharacterized protein 72790 84593296 An16g00360 Aspergillus niger uncharacterized protein XP_059602676.1 71118 R 5061 CDS An16g00370 4988419 join(73025..73091,73137..73193,73240..73286,73506..73567,73714..74136,74199..74437,74492..74697) V 1 NT_166531.1 Title: weak similarity to pneumococcal surface protein A PspA - Streptococcus pneumoniae; uncharacterized protein 74697 4988419 An16g00370 Aspergillus niger uncharacterized protein XP_001397351.3 73025 D 5061 CDS An16g00380 4988432 complement(join(74928..77016,77194..77357)) V 1 NT_166531.1 Remark: the Schizosaccharomyces pombe thi1 gene acts as an activator of several thiamine-repressible genes which are involved in the control of thiamine metabolism.; Similarity: belongs to the unassigned GAL4-type zinc cluster proteins.; Title: similarity to thiamine-repressible protein thi1p - Schizosaccharomyces pombe; See PMID 8088540; See PMID 1551569; uncharacterized protein 77357 4988432 An16g00380 Aspergillus niger uncharacterized protein XP_059602677.1 74928 R 5061 CDS An16g00390 4988433 join(79527..79562,79719..80067,80117..80904) V 1 NT_166531.1 Catalytic activity: salicylate + NADH + O2 = catechol + NAD+ + H2O + CO2.; Pathway: phenylalanine metabolism.; Remark: in this contig there is putative a second salicylate hydroxylase in ORF 25CK.; Remark: shows also strong similarity to 6-hydroxynicotinic acid mono-oxygenase patent JP09121864-A - Pseudomonas fluorescens.; Remark: two genes, nahG and nahW, encoding two independent salicylate 1-hydroxylases have been identified in the naphthalene-degrading strain Pseudomonas stutzeri AN10.; Similarity: belongs to the tetracycline 6-hydroxylase family.; Title: strong similarity to salicylate hydroxylase nahW - Pseudomonas stutzeri; See PMID 10197990; uncharacterized protein 80904 4988433 An16g00390 Aspergillus niger uncharacterized protein XP_059602678.1 79527 D 5061 CDS An16g00400 4988434 join(81423..81813,81871..81954,82012..82102,82157..82277,82328..82747) V 1 NT_166531.1 Catalytic activity: alcohol + NAD+ = aldehyde or ketone + NADH.; Pathway: glycolysis / gluconeogenesis; fatty acid metabolism; bile acid biosynthesis; tyrosine metabolism; glycerolipid metabolism.; Remark: four structural genes encoding isozymes of the alcohol dehydrogenase (ADH) system in the yeast Kluyveromyces lactis.; Remark: strong similarity to Aspergillus sp. alcohol dehydrogenase #1 patent US5958784-A.; Similarity: belongs to the Zn-dependent alcohol dehydrogenases.; Title: strong similarity to alcohol dehydrogenase 3 ADH3 - Candida sphaerica; See PMID 2190430; See PMID 1872030; uncharacterized protein 82747 4988434 An16g00400 Aspergillus niger uncharacterized protein XP_001397354.1 81423 D 5061 CDS An16g00410 4988435 complement(join(82957..83586,83638..83724,83774..83829,83878..84115)) V 1 NT_166531.1 Remark: strong similarity to human oxidoreductase protein (HORP)-4 patent WO200000622-A2.; Title: strong similarity to human oxidoreductase protein HORP-4 from patent WO200000622-A2 - Homo sapiens; uncharacterized protein 84115 4988435 An16g00410 Aspergillus niger uncharacterized protein XP_001397355.1 82957 R 5061 CDS An16g00420 4988436 join(84636..84903,84963..85582) V 1 NT_166531.1 Remark: shows also strong similarity to unknown aldolases and adducins.; Remark: strong similarity to P. putida R-(-)-mandelate monooxygenase of patent JP10099078-A found in GENESEQPROT:W53916.; Title: strong similarity to R(-)mandelate monooxygenase from patent JP10099078-A - Pseudomonas putida; uncharacterized protein 85582 4988436 An16g00420 Aspergillus niger uncharacterized protein XP_001397356.1 84636 D 5061 CDS An16g00430 4988437 complement(join(85875..87720,87805..88050,88158..88357)) V 1 NT_166531.1 Remark: nit-4, a pathway-specific regulatory gene in the nitrogen circuit of Neurospora crassa, is required for the expression of nit-3 and nit-6, the structural genes which encode nitrate and nitrite reductase.; Similarity: belongs to unassigned GAL4-type zinc cluster proteins.; Title: strong similarity to nitrogen assimilation regulatory protein nit-4 - Neurospora crassa; nucleus; See PMID 1840634; uncharacterized protein 88357 4988437 An16g00430 Aspergillus niger uncharacterized protein XP_059602679.1 85875 R 5061 CDS An16g00435 84593297 88973..89209 V 1 NT_166531.1 Remark: a splice site was detected upstream of the START codon.; hypothetical protein 89209 84593297 An16g00435 Aspergillus niger hypothetical protein XP_059602680.1 88973 D 5061 CDS An16g00440 4988439 complement(join(89582..89945,90007..90373,90439..90667)) V 1 NT_166531.1 Catalytic activity: vestitone + NADP+ = 2'-hydroxyformononetin + NADPH.; Remark: also strong similarity to alfalfa isoflavone reductase from Medicago sativa cv. Apollo patent WO9615239-A2.; Remark: play a distinct role in plant antioxidant defense and are possibly involved in NAD(P)/NAD(P)H homeostasis.; Similarity: belongs to the 2'-hydroxyisoflavone reductases.; Title: strong similarity to 2-hydroxyisoflavone reductase IFRH - Arabidopsis thaliana; See PMID 7592828; uncharacterized protein 90667 4988439 An16g00440 Aspergillus niger uncharacterized protein XP_001397359.1 89582 R 5061 CDS An16g00450 4988440 complement(91102..92001) V 1 NT_166531.1 Catalytic activity: 2-pyrone-4,6-dicarboxylate + H2O = 4-carboxy-2-hydroxyhexa-2,4-dienedioate.; Pathway: phenylalanine metabolism.; Remark: LigI activity was inhibited by the addition of thiol reagents, suggesting that the cysteine residue is a catalytic site. LigI is more resistant to metal ion inhibition than the PDC hydrolases of Pseudomonas ochraceae.; Title: similarity to 2-pyrone-4,6-dicarboxylic acid hydrolase LigI - Sphingomonas paucimobilis; See PMID 9864312; uncharacterized protein 92001 4988440 An16g00450 Aspergillus niger uncharacterized protein XP_001397360.1 91102 R 5061 CDS An16g00460 4988441 join(92894..93266,93318..93464,93515..94245,94312..94509) V 1 NT_166531.1 Remark: alternate names are A616; YKL217w.; Remark: disruption of JEN1 S. cerevisiae abolished the uptake of pyruvate and gained the resistance against fluoropyruvate. No other monocarboxylate permease is able to efficiently transport lactate in S. cerevisiae.; Title: strong similarity to carboxylic acid transport protein Jen1 - Saccharomyces cerevisiae; See PMID 10198029; See PMID 10879467; uncharacterized protein 94509 4988441 An16g00460 Aspergillus niger uncharacterized protein XP_001397361.1 92894 D 5061 CDS An16g00470 84593298 join(94764..94953,95117..95183,95222..95435,95858..95896,95993..96046) V 1 NT_166531.1 hypothetical protein 96046 84593298 An16g00470 Aspergillus niger hypothetical protein XP_059602681.1 94764 D 5061 CDS An16g00480 84593299 complement(join(96173..96273,96398..96599)) V 1 NT_166531.1 hypothetical protein 96599 84593299 An16g00480 Aspergillus niger hypothetical protein XP_059602682.1 96173 R 5061 CDS An16g00490 84593300 join(97095..97101,97417..97473,97662..97769,98053..98139,98688..98776) V 1 NT_166531.1 hypothetical protein 98776 84593300 An16g00490 Aspergillus niger hypothetical protein XP_059602683.1 97095 D 5061 CDS An16g00500 4988445 join(99209..100163,100230..100645) V 1 NT_166531.1 Remark: there is weak similarity to Membrane-bound protein PRO1006 Homo sapiens patent WO9963088-A2.; Title: similarity to hypothetical F10K1.17 -Arabidopsis thaliana; uncharacterized protein 100645 4988445 An16g00500 Aspergillus niger uncharacterized protein XP_001397365.1 99209 D 5061 CDS An16g00520 4988446 join(104494..104601,104660..104785,104817..104906,104956..105141,105194..105446,105503..105694,105743..105966) V 1 NT_166531.1 Remark: putative salicylate hydroxylase.; Remark: strong similarity to 6-hydroxynicotinic acid mono-oxygenase patent JP09121864-A - Pseudomonas fluorescens.; Remark: useful for industrial production of 2,5-di:hydroxy:pyridine.; Title: strong similarity to 6-hydroxynicotinic acid mono-oxygenase from patent JP09121864-A - Pseudomonas fluorescens; uncharacterized protein 105966 4988446 An16g00520 Aspergillus niger uncharacterized protein XP_059602684.1 104494 D 5061 CDS An16g00530 4988447 join(106745..106780,106832..>107422) V 1 NT_166531.1 Function: tatD proteins are not required in sec-independent protein export like other tat proteins, but tatD of E. coli exhibits magnesium-dependent DNase activity.; Remark: C-terminal truncated ORF due to end of contig.; Title: strong similarity to cytoplasmic protein tatD - Escherichia coli [truncated ORF]; See PMID 10747959; uncharacterized protein 107422 4988447 An16g00530 Aspergillus niger uncharacterized protein XP_001397367.3 106745 D 5061 CDS An16g00540 4988448 complement(join(<107571..108364,108414..108637,108685..109157)) V 1 NT_166531.1 Remark: C-terminal truncated ORF due to end of contig.; Title: similarity to large secreted protein -Streptomyces coelicolor [truncated ORF]; uncharacterized protein 109157 4988448 An16g00540 Aspergillus niger uncharacterized protein XP_001397368.1 107571 R 5061 CDS An16g00550 4988449 complement(join(109653..110053,110111..110550,110608..110780)) V 1 NT_166531.1 Catalytic activity: R-CN + H2O = R-COOH + NH3.; Remark: acts on a wide range of aromatic nitriles including (indole-3-yl)acetonitrile, and also on some aliphatic nitriles, and on the corresponding acid amides.; Similarity: belongs to the family of nitrilases.; Title: strong similarity to nitrilase - Rhodococcus rhodochrous; See PMID 1400390; uncharacterized protein 110780 4988449 An16g00550 Aspergillus niger uncharacterized protein XP_001397369.1 109653 R 5061 CDS An16g00560 84593301 join(111002..111177,111255..111402) V 1 NT_166531.1 hypothetical protein 111402 84593301 An16g00560 Aspergillus niger hypothetical protein XP_059604731.1 111002 D 5061 CDS An16g00570 84593302 complement(join(111715..111764,111941..112030,112217..112274)) V 1 NT_166531.1 Title: questionable ORF; uncharacterized protein 112274 84593302 An16g00570 Aspergillus niger uncharacterized protein XP_059604732.1 111715 R 5061 CDS An16g00580 84593303 complement(join(112641..112697,112789..112876,113146..113324)) V 1 NT_166531.1 hypothetical protein 113324 84593303 An16g00580 Aspergillus niger hypothetical protein XP_059604733.1 112641 R 5061 CDS An16g00590 84593304 complement(join(113361..113602,113697..113794,113881..113912)) V 1 NT_166531.1 hypothetical protein 113912 84593304 An16g00590 Aspergillus niger hypothetical protein XP_059604734.1 113361 R 5061 CDS An16g00600 4988454 113951..117046 V 1 NT_166531.1 Remark: saframycin Mx1 is a DNA-binding antibiotic and antitumour agent produced by Myxococcus xanthus.; Similarity: to nonribosomal peptide synthetases.; Title: similarity to saframycin Mx1 synthase safA -Myxococcus xanthus; See PMID 8936303; uncharacterized protein 117046 4988454 An16g00600 Aspergillus niger uncharacterized protein XP_001397374.1 113951 D 5061 CDS An16g00610 84593305 complement(join(117807..117943,118016..118053,118270..118314,118349..118395)) V 1 NT_166531.1 hypothetical protein 118395 84593305 An16g00610 Aspergillus niger hypothetical protein XP_059604735.1 117807 R 5061 CDS An16g00620 84593306 118912..119307 V 1 NT_166531.1 hypothetical protein 119307 84593306 An16g00620 Aspergillus niger hypothetical protein XP_059604736.1 118912 D 5061 CDS An16g00630 84593307 120604..121248 V 1 NT_166531.1 Catalytic activity: 2 RH + 2 chloride + H(2)O(2) = 2 RCl + 2 H(2)O.; Function: CPO of L. fumago catalyzes peroxidative halogenations involved in the biosynthesis of clardariomycin (2,2-dichloro-1,3-cyclo-pentenedione), the enzyme also has potent catalase activity and in the absence of halide ion, acts as a peroxidase similar to plant peroxidases.; Remark: CPO of L. fumago was also produced as recombinant protein in A. niger.; Remark: Leptoxyphium fumago is also called Caldariomyces fumago.; Remark: the enzyme catalyzes the chlorination of a range of organic molecules, forming stable C-Cl bonds; the structure and enzymatic activity of the molecule were deeply characterized and studied due to the potential application e. g. in the synthesis of vicinal dihalides,which are important as industrial solvents, refrigerants,flame retardants, and fumigating agents.; Similarity: the C-terminal part of the predicted protein does not shows similarity to CPO of L. fumago, and the protein length is different; thus the function prediction must be considered hypothetical.; Title: similarity to chloride peroxidase precursor CPO - Leptoxyphium fumago; See PMID 3198598; See PMID 3771564; See PMID 3774552; See PMID 2828306; See PMID 2883934; uncharacterized protein 121248 84593307 An16g00630 Aspergillus niger uncharacterized protein XP_059604737.1 120604 D 5061 CDS An16g00640 84593308 122114..122407 V 1 NT_166531.1 Function: the similarity is too weak to assign a function to the predicted protein.; Remark: human CDKN2A is also known as p16.; Title: weak similarity to cyclin dependent kinase inhibitor CDKN2A - Homo sapiens; See PMID 8259215; uncharacterized protein 122407 84593308 An16g00640 Aspergillus niger uncharacterized protein XP_059604738.1 122114 D 5061 CDS An16g00650 4988459 complement(join(122683..123948,124011..124079,124136..124324)) V 1 NT_166531.1 Induction: in S. cerevisiae the relatively high basal level of DAL5 expression did not increase further upon addition of allantoin pathway intermediates.; Repression: in S. cerevisiae steady-state DAL5 mRNA levels dropped precipitously when a repressive nitrogen source was provided.; Similarity: S. cerevisiae DAL5 specifies the Dal5p subfamily of the major facilitator family, which also includes YGR260w and YLR004c.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 3275614; See PMID 10869563; uncharacterized protein 124324 4988459 An16g00650 Aspergillus niger uncharacterized protein XP_001397379.1 122683 R 5061 CDS An16g00660 4988460 complement(join(124642..126007,126141..126367)) V 1 NT_166531.1 Similarity: whereas the patented protein is a linoleate isomerase, the predicted ORF shows a structural domain typical of oxidoreductases; some short alignments to oxidoreductases are also identified by database search.; Title: similarity to linoleate isomerase from patent WO200100846-A2 - Propionibacterium acnes; uncharacterized protein 126367 4988460 An16g00660 Aspergillus niger uncharacterized protein XP_001397380.3 124642 R 5061 CDS An16g00670 4988461 complement(join(126902..127182,127239..127565,127618..127783)) V 1 NT_166531.1 Title: similarity to hypothetical protein AAO51454.1 - Dictyostelium discoideum; uncharacterized protein 127783 4988461 An16g00670 Aspergillus niger uncharacterized protein XP_059604739.1 126902 R 5061 CDS An16g00680 4988462 complement(join(129396..129859,129914..130162,130221..130368)) V 1 NT_166531.1 Remark: RTM loci are always physically associated with SUC telomeric loci. The SUC-RTM sequences are located between X and Y' subtelomeric sequences at chromosome ends.; Remark: RTM1 in S. cerevisiae confers resistance to the toxicity of molasses.; Remark: The particular subtelomeric position might explain the SUC-RTM sequence amplification observed in the genome of yeasts used in industrial biomass or ethanol production with molasses as substrate.; Title: strong similarity to molasses resistency protein Rtm1 - Saccharomyces cerevisiae; See PMID 7672593; uncharacterized protein 130368 4988462 An16g00680 Aspergillus niger uncharacterized protein XP_001397382.1 129396 R 5061 CDS An16g00700 4988463 complement(130812..132431) V 1 NT_166531.1 Title: strong similarity to hypothetical iron-sulfur binding oxidoreductase - Streptomyces coelicolor; uncharacterized protein 132431 4988463 An16g00700 Aspergillus niger uncharacterized protein XP_001397383.3 130812 R 5061 CDS An16g00710 4988464 join(133445..133687,133757..133981,134057..134218,134281..134373,134436..134561) V 1 NT_166531.1 Function: RD20 of A. thaliana is involved in seed dehydration.; Induction: RD20 of A. thaliana is inducible by abscisic acid under hyperosmotic stress conditions such as drought or high salinity.; Title: strong similarity to calcium-binding protein RD20 - Arabidopsis thaliana; See PMID 10965948; uncharacterized protein 134561 4988464 An16g00710 Aspergillus niger uncharacterized protein XP_001397384.1 133445 D 5061 CDS An16g00720 4988465 complement(join(134722..134991,135044..135136,135188..135685,135741..135953,136004..136129,136181..136411)) V 1 NT_166531.1 Function: TNA1 of S. cerevisiae is necessary for nicotinic acid uptake.; Remark: the systematic gene name of TNA1 in S. cerevisiae is YGR260w.; Similarity: belongs to the family of allantoate permeases.; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563; See PMID 10984621; uncharacterized protein 136411 4988465 An16g00720 Aspergillus niger uncharacterized protein XP_001397385.1 134722 R 5061 CDS An16g00730 4988466 complement(join(136892..137219,137274..137365,137413..137536,137584..137674,137725..137838,137882..137933,137981..138034,138096..138255,138313..138383,138432..138485,138535..138616,138660..138739,138789..138866,138922..139023)) V 1 NT_166531.1 Function: FEN2 of S. cerevisiae is involved in the concerted regulation between the different pathways of carbon/nitrogen catabolite repression and the biosynthesis of amino acids and ergosterol.; Function: Fen2p of S. cerevisiae facilitates the cotransport of H+ and pantothenate.; Phenotype: fen2 mutants of S. cerevisiae are resistant to the antifungal drug fenpropimorph and display a reduced rate of ergostyrol synthesis in media exerting both carbon and nitrogen catabolite repression.; Remark: the systematic gene name of FEN2 of S. cerevisiae is YCR028c.; Title: strong similarity to pantothenate transporter protein Fen2 - Saccharomyces cerevisiae; plasma membrane; See PMID 8771708; See PMID 10373490; uncharacterized protein 139023 4988466 An16g00730 Aspergillus niger uncharacterized protein XP_059604740.1 136892 R 5061 CDS An16g00740 4988467 complement(join(139568..139905,139964..140384,140452..140610)) V 1 NT_166531.1 Similarity: also shows smilarity to nitrogen metabolic repression proteins (nmr) of various fungal species.; Similarity: shows strong homology to protein patent database entry GENESEQPROT:Y14147.; Similarity: the protein sequence of patent Y14147 is identical with the sequence of the human HSCARG gene product.; Title: strong similarity to actVA-ORF4-like protein from patent WO9911793-A1 - Homo sapiens; uncharacterized protein 140610 4988467 An16g00740 Aspergillus niger uncharacterized protein XP_059604741.1 139568 R 5061 CDS An16g00750 4988468 complement(join(141165..142733,142813..143226)) V 1 NT_166531.1 Function: CHA4 of S. cerevisiae activates the transcription of CHA1 which encodes a Ser/Thr deaminase involved in the utilization of serine and threonine as nitrogen sources.; Similarity: contains a domain homologous to fungal Zn(2)-Cys(6) binuclear cluster in which all six Cys residues are conserved.; Title: similarity to transcription activator Cha4 -Saccharomyces cerevisiae; See PMID 8889513; uncharacterized protein 143226 4988468 An16g00750 Aspergillus niger uncharacterized protein XP_001397388.1 141165 R 5061 CDS An16g00760 4988469 complement(join(143881..144675,144738..144841,144938..144995)) V 1 NT_166531.1 Remark: possible sequencing error destroying a splicing donor site at position 37991.; Similarity: the homology region does not include the SH3 domain of Sh3yl1 of M. musculus.; Title: similarity to differentially expressed protein Sh3yl1 - Mus musculus [putative sequencing error]; See PMID 10771491; uncharacterized protein 144995 4988469 An16g00760 Aspergillus niger uncharacterized protein XP_001397389.1 143881 R 5061 CDS An16g00770 84593309 join(147763..147962,148111..148488,148557..148634,148705..149056,149232..>149740) V 1 NT_166531.1 Function: the cDNA corresponding to the protein of patent W14439 can be used to improve the fermentation ability of Acremonium chrysogenum.; Function: the protein of patent W14439 is involved in cyclosporin C biosynthesis.; Remark: a putative sequencing error results in an frameshift.; Similarity: also shows strong similarity to multidrug transporters of diverse fungal species.; Similarity: shows strong homology to protein patent database entry GENESEQPROT:W14439.; Title: strong similarity to protein involved in cephalosporin C biosynthesis from patent JP09009966-A -Acremonium chrysogenum [putative frameshift]; putative frameshift; uncharacterized protein 149740 84593309 An16g00770 Aspergillus niger uncharacterized protein XP_059604742.1 147763 D 5061 CDS An16g00780 4988471 complement(join(149846..150761,150818..151401)) V 1 NT_166531.1 Function: TetA of A. tumefaciens C58 confers resistance to tetracyclin and some of it's derivatives.; Repression: TetA expression in A. tumefaciens C58 is repressed by the transcriptional regulator TetR.; Title: strong similarity to tetracyclin resistance protein tetA - Agrobacterium tumefaciens; plasma membrane; See PMID 9882678; uncharacterized protein 151401 4988471 An16g00780 Aspergillus niger uncharacterized protein XP_001397391.1 149846 R 5061 CDS An16g00790 84593310 join(151578..151709,151841..152152) V 1 NT_166531.1 hypothetical protein 152152 84593310 An16g00790 Aspergillus niger hypothetical protein XP_059604743.1 151578 D 5061 CDS An16g00800 4988473 complement(join(152325..152568,152624..152755,152808..153794,153861..154177,154210..154269,154366..154419)) V 1 NT_166531.1 Function: Flu1 of C. albicans confers resistance to various antibiotics including fluconazole and cycloheximide.; Similarity: FLU1 of C. albicans belongs to the major facilitator superfamily.; Title: strong similarity to fluonazole resistance protein FLU1 - Candida albicans; See PMID 11065353; uncharacterized protein 154419 4988473 An16g00800 Aspergillus niger uncharacterized protein XP_001397393.3 152325 R 5061 CDS An16g00810 4988474 complement(join(155240..155433,155486..155572,155629..155746,155796..155977,156025..156097,156145..156751,156805..156980,157029..157311,157363..157493,157548..157706,157756..157832,157892..157948,158008..158200)) V 1 NT_166531.1 Function: HGT1 of S. cerevisiae is described as a high-affinity glutathion transporter.; Function: OPT1 of S. cerevisiae is described as an oligopeptide transporter specific for tetra- and pentapeptides including the endogenous opioids leucine enkephalin (YGGFL) and methionine enkephalin (YGGFM).; Remark: the systematic name of OPT1/HGT1 of S. cerevisiae is YJL212c.; Title: strong similarity to oligopeptide transporter Opt1 - Saccharomyces cerevisiae; plasma membrane; See PMID 10652283; See PMID 10788431; uncharacterized protein 158200 4988474 An16g00810 Aspergillus niger uncharacterized protein XP_001397394.1 155240 R 5061 CDS An16g00820 84593311 join(159374..159474,159591..159699,159805..160038) V 1 NT_166531.1 hypothetical protein 160038 84593311 An16g00820 Aspergillus niger hypothetical protein XP_059604744.1 159374 D 5061 CDS An16g00830 4988476 join(160537..160690,160743..161506) V 1 NT_166531.1 Title: similarity to hypothetical protein encoded by An14g02830 - Aspergillus niger; uncharacterized protein 161506 4988476 An16g00830 Aspergillus niger uncharacterized protein XP_001397396.1 160537 D 5061 CDS An16g00840 4988477 complement(join(162415..162598,162662..162708)) V 1 NT_166531.1 Title: similarity to hypothetical protein encoded by An18g01250 - Aspergillus niger; uncharacterized protein 162708 4988477 An16g00840 Aspergillus niger uncharacterized protein XP_001397397.1 162415 R 5061 CDS An16g00850 4988478 join(163574..163629,163684..164139,164194..164386) V 1 NT_166531.1 Title: strong similarity to hypothetical protein SPAC9E9.15 - Schizosaccharomyces pombe; uncharacterized protein 164386 4988478 An16g00850 Aspergillus niger uncharacterized protein XP_001397398.1 163574 D 5061 CDS An16g00860 4988479 complement(164439..165902) V 1 NT_166531.1 Title: similarity to hypothetical protein aos20 -Aspergillus oryzae; uncharacterized protein 165902 4988479 An16g00860 Aspergillus niger uncharacterized protein XP_001397399.1 164439 R 5061 CDS An16g00870 84593312 complement(join(166118..166312,166581..166628,166761..166943)) V 1 NT_166531.1 hypothetical protein 166943 84593312 An16g00870 Aspergillus niger hypothetical protein XP_059604745.1 166118 R 5061 CDS An16g00880 84593313 complement(join(167424..167491,167544..167758,167812..167953,168215..168623)) V 1 NT_166531.1 hypothetical protein 168623 84593313 An16g00880 Aspergillus niger hypothetical protein XP_059604746.1 167424 R 5061 CDS An16g00890 4988482 join(169209..170391,170443..170909) V 1 NT_166531.1 Title: strong similarity to hypothetical protein PA2448 - Pseudomonas aeruginosa; uncharacterized protein 170909 4988482 An16g00890 Aspergillus niger uncharacterized protein XP_001397402.1 169209 D 5061 CDS An16g00900 4988483 join(171141..171391,171444..171646,171700..172352) V 1 NT_166531.1 Similarity: shows homology to hypothetical hydrolases from S. coelicolor and P. aeruginosa.; Title: weak similarity to sequence 259 from patent WO0100842 - Corynebacterium glutamicum; uncharacterized protein 172352 4988483 An16g00900 Aspergillus niger uncharacterized protein XP_001397403.3 171141 D 5061 CDS An16g00910 4988484 172631..173962 V 1 NT_166531.1 Remark: the patent does not provide further information about the function of the protein.; Similarity: encodes a hypothetical NADH-dependent flavin oxidoreductase of the Old Yellow Enzyme family.; Title: strong similarity to sequence 385 from patent WO0100842 - Corynebacterium glutamicum; uncharacterized protein 173962 4988484 An16g00910 Aspergillus niger uncharacterized protein XP_001397404.1 172631 D 5061 CDS An16g00920 4988485 join(174371..174417,174470..174582,174646..174809,174884..175024,175088..175123) V 1 NT_166531.1 Catalytic activity: PMP20 of C. boidinii displays glutathione peroxidase activity toward alkyl hydroperoxides and H2O2.; Function: PMP20 of C. boidinii acts as an antioxidant enzyme decomposing reactive oxygen species generated at the peroxisomal membrane surface, e. g. lipid hydroperoxides.; Induction: PMP20 of C. boidinii is specific to peroxisomes induced by methanol utilization.; Localization: PMP20 of C. boidinii is peripherally associated with the inner side of the peroxisomal membrane.; Similarity: belongs to the peroxiredoxin 2 family.; Title: strong similarity to peroxisomal membrane protein PMP20 - Candida boidinii; peroxisome; See PMID 11278957; See PMID 2258389; See PMID 2760051; uncharacterized protein 175123 4988485 An16g00920 Aspergillus niger uncharacterized protein XP_001397405.1 174371 D 5061 CDS An16g00930 4988486 join(176397..176474,176544..176781,176858..177246) V 1 NT_166531.1 Similarity: the hypothetical protein NonF of Streptomyces griseus is probably involved in nonactin biosynthesis.; Title: similarity to hypothetical protein of the nonactin biosynthesis cluster nonF - Streptomyces griseus; uncharacterized protein 177246 4988486 An16g00930 Aspergillus niger uncharacterized protein XP_001397406.1 176397 D 5061 CDS An16g00940 4988487 complement(join(177497..178391,178437..178766,178811..178884,178928..178949,178995..179260)) V 1 NT_166531.1 Function: Flu1 of C. albicans confers resistance to various antibiotics including fluconazole and cycloheximide.; Similarity: FLU1 of C. albicans belongs to the major facilitator superfamily.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353; uncharacterized protein 179260 4988487 An16g00940 Aspergillus niger uncharacterized protein XP_001397407.1 177497 R 5061 CDS An16g00950 84593314 join(179729..179761,179844..179968,180063..180223,180349..180569) V 1 NT_166531.1 hypothetical protein 180569 84593314 An16g00950 Aspergillus niger hypothetical protein XP_059604747.1 179729 D 5061 CDS An16g00960 4988489 180699..181871 V 1 NT_166531.1 Function: severin of D. discoideum binds to the plus (or barbed) ends of actin monomers or filaments,preventing monomer exchange (end-blocking or capping).; Function: severin of D. discoideum can promote assembly of monomers into filaments (nucleation) as well as disassociation (severing) of filaments already formed.; Function: the actin capping, severing and nucleating activities of severin of D. discoideum are Ca2+ dependent.; Similarity: contains a region highly homologous to a conserved actin-binding sequence duplicated in villin and gelsolin.; Title: strong similarity to actin-modulating protein severin - Dictyostelium discoideum; See PMID 1847147; See PMID 2826459; uncharacterized protein 181871 4988489 An16g00960 Aspergillus niger uncharacterized protein XP_001397409.1 180699 D 5061 CDS An16g00970 84593315 complement(join(182148..182219,182295..182344,182385..182550)) V 1 NT_166531.1 Similarity: shows deliberate homology matches to glycine-rich domains of various proteins from diverse species.; Title: weak similarity to hypothetical protein FB19 - Homo sapiens; uncharacterized protein 182550 84593315 An16g00970 Aspergillus niger uncharacterized protein XP_059604748.1 182148 R 5061 CDS An16g00980 84593316 complement(join(<182827..183356,183390..183812,183867..184631,185028..>185066)) V 1 NT_166531.1 Function: the acr-2 gene of Neurospora crassa controls acriflavine sensitivity.; Remark: the predicted ACR-2 protein has a putative Zn(II)Cys6 binuclear domain near the amino-terminus.; Title: weak similarity to transcription factor involved in acriflavine resistance acr-2 - Neurospora crassa; See PMID 8679704; uncharacterized protein 185066 84593316 An16g00980 Aspergillus niger uncharacterized protein XP_059606538.1 182827 R 5061 CDS An16g00990 4988492 join(185503..185538,185598..186008,186113..186568) V 1 NT_166531.1 Catalytic activity: vestitone + NADP(+) = 2'-hydroxyformononetin + NADPH. in the reverse direction, a 2'-hydroxyisoflavone is reduced to an isoflavonone.; Complex: IRL of Z. mays exists as a monomer.; Induction: IRL of Z. mays is induced by sulfur starvation.; Title: similarity to 2-hydroxyisoflavone reductase IRL - Zea mays; cytoplasm; See PMID 8597660; uncharacterized protein 186568 4988492 An16g00990 Aspergillus niger uncharacterized protein XP_001397412.1 185503 D 5061 CDS An16g01000 4988493 complement(join(186656..187087,187163..187565,187628..188051,188114..188327)) V 1 NT_166531.1 Remark: the ophD gene from Burkholderia cepacia encodes a permease for phthalate transport.; Remark: uptake inhibition experiments show that 4-hydroxyphthalate, 4-chlorophthalate, 4-methylphthalate,and cinchomeronate compete for the phthalate permease.; Title: strong similarity to phthalate permease ophD - Burkholderia cepacia; See PMID 9851995; uncharacterized protein 188327 4988493 An16g01000 Aspergillus niger uncharacterized protein XP_001397413.1 186656 R 5061 CDS An16g01010 4988494 join(188878..189609,189685..>189823) V 1 NT_166531.1 Similarity: the ORF is similar to the hypothetical protein SPAC5H10. 01 of S. pombe and hypothetical proteins from several prokaryotic species.; Title: strong similarity to hypothetical protein SPAC5H10.01 - Schizosaccharomyces pombe [truncated ORF]; uncharacterized protein 189823 4988494 An16g01010 Aspergillus niger uncharacterized protein XP_001397414.3 188878 D 5061 CDS An16g01020 4988495 complement(join(<189925..191049,191102..191858,191911..192033,192104..192213)) V 1 NT_166531.1 Similarity: the ORF is shorter than the hypothetical nuclear protein of S. pombe (615 compared to 743 amino acids). 176 N-terminal and 101 C-terminal amino acids of the ORF are not included in the alignment between the two proteins.; Title: similarity to hypothetical transcription regulator SPBC530.05 - Schizosaccharomyces pombe; See PMID 10759889; uncharacterized protein 192213 4988495 An16g01020 Aspergillus niger uncharacterized protein XP_059606627.1 189925 R 5061 CDS An16g01030 4988496 complement(join(192675..193049,193100..193422,193473..194106,194184..194402)) V 1 NT_166531.1 Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O (by similarity); Similarity: belongs to the cytochrome P450 family; Title: strong similarity to phenylacetate hydroxylase pahA - Penicillium chrysogenum; See PMID 10329644; uncharacterized protein 194402 4988496 An16g01030 Aspergillus niger uncharacterized protein XP_001397416.1 192675 R 5061 CDS An16g01040 4988497 complement(195976..197604) V 1 NT_166531.1 Title: strong similarity to hypothetical MFS multidrug efflux transporter - Schizosaccharomyces pombe; uncharacterized protein 197604 4988497 An16g01040 Aspergillus niger uncharacterized protein XP_001397417.1 195976 R 5061 CDS An16g01050 84593317 complement(join(198300..198504,198632..198828)) V 1 NT_166531.1 hypothetical protein 198828 84593317 An16g01050 Aspergillus niger hypothetical protein XP_059606628.1 198300 R 5061 CDS An16g01060 84593318 join(199065..199197,199393..199706) V 1 NT_166531.1 hypothetical protein 199706 84593318 An16g01060 Aspergillus niger hypothetical protein XP_059606629.1 199065 D 5061 CDS An16g01070 84593319 complement(join(199752..199898,200017..200076,200151..200240,200320..200406,200498..200929,201036..201210,201267..201422,201492..201695,201746..201875,201923..202587,202631..202713,202765..202833)) V 1 NT_166531.1 Function: nit-4 of N. crassa is a transcription factor activating gene expression of nitrate assimilatory genes nit-3 and nit-6, which encode nitrate reductase and nitrite reductase, respectively.; Remark: activation of nit-3 and nit-6 requires the synergisitc interaction of the global-acting nit-2 with the pathway-specific nit-4 transcription factors.; Similarity: protein with a putative binuclear zinc DNA-binding domain; Title: strong similarity to nitrogen assimilation regulatory protein nit-4 - Neurospora crassa; nucleus; See PMID 1531376; uncharacterized protein 202833 84593319 An16g01070 Aspergillus niger uncharacterized protein XP_059606630.1 199752 R 5061 CDS An16g01080 4988501 complement(join(203208..203750,203807..203962,204015..204101,204164..204199)) V 1 NT_166531.1 Title: strong similarity to hypothetical short chain dehydrogenase SPAC521.03 - Schizosaccharomyces pombe; uncharacterized protein 204199 4988501 An16g01080 Aspergillus niger uncharacterized protein XP_001397421.1 203208 R 5061 CDS An16g01090 4988502 join(204559..204582,204625..204935,204993..205200,205257..205460,205521..205811,205871..206047) V 1 NT_166531.1 Catalytic activity: An epoxide + H(2)O <=> a glycol.; Title: strong similarity to epoxide hydrolase -Rattus norvegicus; endosome; See PMID 3032949; See PMID 3755318; uncharacterized protein 206047 4988502 An16g01090 Aspergillus niger uncharacterized protein XP_059606631.1 204559 D 5061 CDS An16g01100 84593320 join(206439..206556,206713..206762,206866..206899,206985..207130) V 1 NT_166531.1 hypothetical protein 207130 84593320 An16g01100 Aspergillus niger hypothetical protein XP_059606632.1 206439 D 5061 CDS An16g01110 4988504 join(207426..207485,207557..207782,207896..208155,208212..209219) V 1 NT_166531.1 Title: similarity to hypothetical negative acting factor like protein CAB91400.2 - Neurospora crassa; uncharacterized protein 209219 4988504 An16g01110 Aspergillus niger uncharacterized protein XP_059606633.1 207426 D 5061 CDS An16g01120 4988505 complement(210134..211522) V 1 NT_166531.1 Title: similarity to hypothetical membrane protein YPL277c - Saccharomyces cerevisiae; uncharacterized protein 211522 4988505 An16g01120 Aspergillus niger uncharacterized protein XP_001397425.3 210134 R 5061 CDS An16g01130 4988506 complement(join(212155..212659,212724..213169,213226..213395,213425..213452)) V 1 NT_166531.1 Title: strong similarity to hypothetical plasma membrane iron permease - Schizosaccharomyces pombe; uncharacterized protein 213452 4988506 An16g01130 Aspergillus niger uncharacterized protein XP_059606634.1 212155 R 5061 CDS An16g01140 84593321 join(213847..213890,213960..214211,214495..214600,214739..214841,214973..215217,215318..215444,215624..215765,215840..216071) V 1 NT_166531.1 hypothetical protein 216071 84593321 An16g01140 Aspergillus niger hypothetical protein XP_059606635.1 213847 D 5061 CDS An16g01150 4988508 join(216323..216928,216981..217366,217425..217657,217724..217776,217834..217955,218013..219033) V 1 NT_166531.1 Function: Fre1 and Fre2 from S. cerevisiae encode cell surface metalloreductases that are required for reduction and uptake of free ferric iron.; Function: Fre2 from S. cerevisiae is together with Fre1 responsible for the total membrane-associated ferric reductase activity of the cell.; Title: strong similarity to ferric reductase Fre2 -Saccharomyces cerevisiae; See PMID 8164662; See PMID 11120744; uncharacterized protein 219033 4988508 An16g01150 Aspergillus niger uncharacterized protein XP_001397428.1 216323 D 5061 CDS An16g01160 84593322 join(219604..219640,219684..219757,219862..219945,220042..220082,220171..220255) V 1 NT_166531.1 hypothetical protein 220255 84593322 An16g01160 Aspergillus niger hypothetical protein XP_059606636.1 219604 D 5061 CDS An16g01170 4988510 complement(join(<221124..221176,221242..221352,221427..221927,221982..222136,222239..222463,222521..222625,222796..222996,223080..223196)) V 1 NT_166531.1 Function: the pathogenicity protein PTH11 functions at the cell cortex as an upstream effector of appressorium differentiation in response to surface cues.; Localization: a PTH11-green fluorescent protein fusion was localized to the cell membrane and vacuoles.; Remark: C-terminally truncated due to contig border.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea [truncated ORF]; plasma membrane; See PMID 10521529; uncharacterized protein 223196 4988510 An16g01170 Aspergillus niger uncharacterized protein XP_001397430.3 221124 R 5061 CDS An16g01180 84593323 join(223691..223783,224058..224121,224197..224300) V 1 NT_166531.1 hypothetical protein 224300 84593323 An16g01180 Aspergillus niger hypothetical protein XP_059602685.1 223691 D 5061 CDS An16g01190 4988512 complement(join(224478..225027,225136..225533)) V 1 NT_166531.1 Catalytic activity: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.; Function: N-acetylation by hepatic NAT1 is a major route in the metabolism and detoxification of numerous drugs and foreign chemicals.; Remark: NAT1 has a wide specificity for aromatic amines, including serotonin.; Title: strong similarity to arylamine N-acetyltransferase NAT1 - Homo sapiens; See PMID 2340091; See PMID 9168895; uncharacterized protein 225533 4988512 An16g01190 Aspergillus niger uncharacterized protein XP_059602686.1 224478 R 5061 CDS An16g01200 4988513 join(226609..226716,226762..226832,227056..227516,227572..227595,227654..227979,228040..228528) V 1 NT_166531.1 Function: CTR is the sole choline transporter in yeast.; Induction: CTR activity is inhibited by intracellular choline.; Similarity: CTR belongs to the amino acid permease family.; Title: strong similarity to choline permease Hnm1 -Saccharomyces cerevisiae; plasma membrane; See PMID 2203793; uncharacterized protein 228528 4988513 An16g01200 Aspergillus niger uncharacterized protein XP_059602687.1 226609 D 5061 CDS An16g01210 4988514 complement(join(228804..229212,229265..229382,229440..229812,229860..229934)) V 1 NT_166531.1 Function: the pathogenicity protein PTH11 functions at the cell cortex as an upstream effector of appressorium differentiation in response to surface cues.; Localization: a PTH11-green fluorescent protein fusion was localized to the cell membrane and vacuoles.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529; uncharacterized protein 229934 4988514 An16g01210 Aspergillus niger uncharacterized protein XP_001397434.3 228804 R 5061 CDS An16g01220 4988515 complement(join(230548..230637,230909..231028,231330..232571,232641..233507,233579..234139)) V 1 NT_166531.1 Title: similarity to hypothetical protein CAD21096.1 - Neurospora crassa; uncharacterized protein 234139 4988515 An16g01220 Aspergillus niger uncharacterized protein XP_059602688.1 230548 R 5061 CDS An16g01230 4988516 join(234387..235069,235124..235459,235515..236554,236656..236948) V 1 NT_166531.1 Function: brlA has a direct role in the regulation of cell cycle genes.; Function: brlA is a primary regulator of development-specific gene expression during conidiation.; Title: similarity to developmental regulatory protein brlA - Aspergillus nidulans; nucleus; See PMID 10601021; See PMID 3293800; uncharacterized protein 236948 4988516 An16g01230 Aspergillus niger uncharacterized protein XP_059602689.1 234387 D 5061 CDS An16g01240 84593324 join(238049..238165,238231..238319,238398..239268) V 1 NT_166531.1 Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 9383611; See PMID 9987114; See PMID 11152942; See PMID 8710886; uncharacterized protein 239268 84593324 An16g01240 Aspergillus niger uncharacterized protein XP_059602690.1 238049 D 5061 CDS An16g01250 4988518 join(240317..240487,240564..240693,240787..240913,240988..241768) V 1 NT_166531.1 Catalytic activity: 6-OMT catalyzes methylation of the 6-hydroxyl group of norcoclaurine.; Function: 6-OMT is involved in isoquinoline alkaloid biosynthesis in Coptis japonica.; Title: strong similarity to S-adenosyl-L-methionine:norcoclaurine 6-O-methyltransferase 6-OMT - Coptis japonica; See PMID 10811648; uncharacterized protein 241768 4988518 An16g01250 Aspergillus niger uncharacterized protein XP_001397438.1 240317 D 5061 CDS An16g01260 4988519 complement(join(242448..242581,242844..242860,243005..243060,243180..243333,243469..243998,244071..244156,244399..244945,244975..245325)) V 1 NT_166531.1 Function: TPO1 is involved in the resistance of yeast to polyamine toxicity.; Function: the membrane protein TPO1 is a polyamine transport protein on the vacuolar membrane.; Title: strong similarity to polyamine transport protein Tpo1 - Saccharomyces cerevisiae; vacuole; See PMID 9920864; See PMID 11171066; uncharacterized protein 245325 4988519 An16g01260 Aspergillus niger uncharacterized protein XP_059602691.1 242448 R 5061 CDS An16g01270 84593325 join(245565..245732,245870..245947,246035..246393,246430..246574,246679..246830,246899..247081,247185..247262,247348..247480) V 1 NT_166531.1 Function: the pathogenicity protein PTH11 functions at the cell cortex as an upstream effector of appressorium differentiation in response to surface cues.; Localization: a PTH11-green fluorescent protein fusion was localized to the cell membrane and vacuoles.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529; uncharacterized protein 247480 84593325 An16g01270 Aspergillus niger uncharacterized protein XP_059602692.1 245565 D 5061 CDS An16g01280 4988521 247683..248996 V 1 NT_166531.1 Catalytic activity: salicylate + NADH + O(2) = catechol + NAD(+) + H(2)O + CO(2).; Function: nahG catalyzes the formation of catechol from salicylate, a key intermediate in naphthalene catabolism.; Pathway: nahpthalene catabolism and phenylalanine metabolism.; Title: strong similarity to salicylate hydroxylase nahG - Pseudomonas putida; See PMID 1993181; See PMID 2363715; uncharacterized protein 248996 4988521 An16g01280 Aspergillus niger uncharacterized protein XP_001397441.1 247683 D 5061 CDS An16g01290 4988522 join(249561..249749,249804..250673) V 1 NT_166531.1 Title: strong similarity to hypothetical protein encoded by An02g05930 - Aspergillus niger; uncharacterized protein 250673 4988522 An16g01290 Aspergillus niger uncharacterized protein XP_059602693.1 249561 D 5061 CDS An16g01300 84593326 complement(<251182..251451) V 1 NT_166531.1 Remark: the ORF is C-terminally truncated due to end of contig.; Title: similarity to hypothetical protein encoded by DR2561 - Deinococcus radiodurans [truncated ORF]; uncharacterized protein 251451 84593326 An16g01300 Aspergillus niger uncharacterized protein XP_059602694.1 251182 R 5061 CDS An16g01310 4988524 complement(join(251877..253502,253551..253673,253720..253791)) V 1 NT_166531.1 Catalytic activity: ALS/AHASs catalyze the ThPP- and FAD-dependent biosynthesis of acetohydroxybutyrate from pyruvate and 2-oxobutyrate, as well as of acetolactate from two molecules of pyruvate.; Catalytic activity: Some ALS/AHASs also catalyze the (non-physiological) oxidative decarboxylation of pyruvate,leading to peracetic acid.; Function: bacterial ALS/AHAS consist of catalytic subunits (around 60 kDa) and smaller regulatory subunits in an alpha2beta2 structure.; Function: most ALS/AHAS are under allosteric control by branched-chain amino acids.; Pathway: ALS/AHASs catalyze the first step in the biosynthesis of the branched-chain amino acids valine,isoleucine, and leucine.; Remark: 'acetolactate synthase' (ALS) is often used synonymiously to 'acetohydroxyacid synthase' (AHAS or AHS).; Similarity: highest similarity to acetolactate synthase, large chain (ilvB) of Pyrococcus abyssi (strain Orsay), but there is no reference.; Title: strong similarity to acetohydroxyacid synthase large subunit ilvB - Methanococcus maripaludis; cytoplasm; See PMID 8973202; See PMID 1087175; See PMID 9655946; See PMID 10430574; uncharacterized protein 253791 4988524 An16g01310 Aspergillus niger uncharacterized protein XP_001397444.1 251877 R 5061 CDS An16g01320 4988525 complement(join(254279..255058,255109..255267,255317..255481)) V 1 NT_166531.1 Function: Pth11p of M. grisea functions as an upstream effector of appressorium differentiation in response to host surface recognition but is not required for appressorium morphogenesis.; Function: Pth11p of M. grisea is involved in the response to both host cutin monomers and contact surface hydrophobicity.; Localization: Pth11p of M. grisea functions at the cell cortex, but is also found in the vacuolar membrane.; Localization: contains three probable transmembrane domains.; Repression: Pth11p of M. grisea is probably downregulated by shunting the surface receptor protein to the vacuole by endocytosis.; Similarity: N-terminal three quarters (aa 8-296) show similarity to the middle domain (aa 104-374) of M. grisea PTH11 (631 aa).; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529; uncharacterized protein 255481 4988525 An16g01320 Aspergillus niger uncharacterized protein XP_059602695.1 254279 R 5061 CDS An16g01330 4988526 complement(join(256819..257458,257514..257726,257773..257828,257880..257980,258040..258135,258193..258359,258421..258587)) V 1 NT_166531.1 Function: TNA1 of S. cerevisiae encodes the high affinity nicotinic acid permease.; Function: TNA1 of S. cerevisiae is necessary for nicotinic acid import into the cell.; Remark: the systematic genename of TNA1 in S. cerevisiae is YGR260w.; Similarity: shows also similarity to several probable allantoate transporters.; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563; See PMID 10984621; uncharacterized protein 258587 4988526 An16g01330 Aspergillus niger uncharacterized protein XP_001397446.3 256819 R 5061 CDS An16g01340 4988527 join(260338..260480,260542..260796,260851..260869) V 1 NT_166531.1 Catalytic activity: biphenyl-2,3-diol 1,2-dioxygenases catalyze the extradiol (meta-) cleavage of the first ring of 2,3-dihydroxybiphenyl.; Catalytic activity: ring-cleaving dioxygenase activity requires a coordinated Fe(II)-ion as a cofactor.; Remark: PubMed ID's are given for selected papers on meta-cleaving dioxygenases; Similarity: shares a conserved extradiol ring-cleavage dioxygenase motiv with biphenyl-2,3-diol 1,2-dioxygenase III from Rhodococcus globerulus.; Similarity: weak similarity to N-terminal two thirds of biphenyl-2,3-diol 1,2-dioxygenase III from Rhodococcus globerulus.; Title: strong similarity to hypothetical biphenyl-2,3-diol 1,2-dioxygenase VCA0463 - Vibrio cholerae; See PMID 8126007; See PMID 9857017; See PMID 1444267; See PMID 2670937; uncharacterized protein 260869 4988527 An16g01340 Aspergillus niger uncharacterized protein XP_001397447.1 260338 D 5061 CDS An16g01350 4988528 complement(join(261163..261315,261469..261543,261650..261658)) V 1 NT_166531.1 Title: strong similarity to hypothetical protein CAA10129.1 - Cicer arietinum; uncharacterized protein 261658 4988528 An16g01350 Aspergillus niger uncharacterized protein XP_001397448.1 261163 R 5061 CDS An16g01360 4988529 join(262913..262996,263069..263281,263459..264629,264682..265210,265464..265821) V 1 NT_166531.1 hypothetical protein 265821 4988529 An16g01360 Aspergillus niger hypothetical protein XP_059602696.1 262913 D 5061 CDS An16g01370 4988530 266632..267774 V 1 NT_166531.1 Function: UPC2 of S. cerevisiae is involved in the control of sterol uptake.; Remark: UPC2 belongs to a fungal regulatory family containing the Zn(II)2Cys6 binuclear cluster DNA binding domain.; Remark: UPC2 is synonymous to YDR213W.; Title: similarity to RNA polymerase II transcription factor Upc2 - Saccharomyces cerevisiae; See PMID 9696767; uncharacterized protein 267774 4988530 An16g01370 Aspergillus niger uncharacterized protein XP_001397450.1 266632 D 5061 CDS An16g01380 4988531 complement(join(267857..268099,268149..268380,268428..268693)) V 1 NT_166531.1 Function: idiA of Synechococcus is a protein involved in the process of providing photosystem II with manganese.; Function: inactivation of the idiA gene in Synechococcus results in a mutant which is unable to grow under iron- or manganese-limiting conditions.; Title: weak similarity to iron-deficiency-induced protein IdiA - Synechococcus sp.; See PMID 8828233; uncharacterized protein 268693 4988531 An16g01380 Aspergillus niger uncharacterized protein XP_001397451.1 267857 R 5061 CDS An16g01390 4988532 join(269570..269650,269715..271670) V 1 NT_166531.1 Function: amyR of A. oryzae is a transcriptional activator involved in starch/maltose-induced efficient expression of amylolytic genes.; Similarity: amyR of A. oryzae has a zinc binuclear cluster motif (Zn(II)2Cys6) and belongs to the GAL4 family of transcription factors.; Similarity: similarity is restricted to N-terminal part of the protein.; Title: similarity to transcription regulator of maltose utilization amyR - Aspergillus oryzae; See PMID 10830498; uncharacterized protein 271670 4988532 An16g01390 Aspergillus niger uncharacterized protein XP_001397452.3 269570 D 5061 CDS An16g01400 84593327 join(272760..272818,272914..273083,273134..273627,273680..274735) V 1 NT_166531.1 Function: CTF1alpha of H. haematococca positively acts in vivo by binding selectively to palindrome 2 of the cutinase gene promoter.; Similarity: CTF1alpha of H. haematococca is N-andC-terminally longer than this protein.; Title: similarity to cutinase transcription factor 1 CTF1-alpha - Hematonectria haematococca; See PMID 9139694; uncharacterized protein 274735 84593327 An16g01400 Aspergillus niger uncharacterized protein XP_059602697.1 272760 D 5061 CDS An16g01410 4988534 join(275108..275262,275388..275679,275868..276090,276143..276174,276225..277529) V 1 NT_166531.1 Function: facB of A. nidulans is a transcriptional activator with a GAL4-type Zn(II)2Cys6 zinc binuclear cluster DNA-binding domain which is required for DNA binding.; Function: facB of A. nidulans is required for acetate induction of acetamidase and several acetate utilization enzymes.; Similarity: facB of A. nidulans is C-terminally 200 aa longer.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; See PMID 9197408; See PMID 9524126; uncharacterized protein 277529 4988534 An16g01410 Aspergillus niger uncharacterized protein XP_001397454.3 275108 D 5061 CDS An16g01420 4988535 join(278129..278828,278875..279369,279420..279653,279701..280365,280418..280558,280670..280868,280917..281004,281168..281412,281498..281655,281722..282180,282233..282916) V 1 NT_166531.1 Function: MRP2 of A. thaliana is a multispecific ABC transporter for the transport of both glutathione S-conjugates and chlorophyll catabolites.; Title: similarity to ATP binding cassette transporter AtMRP2 - Arabidopsis thaliana; See PMID 9490749; See PMID 11115509; uncharacterized protein 282916 4988535 An16g01420 Aspergillus niger uncharacterized protein XP_059602698.1 278129 D 5061 CDS An16g01430 84593328 complement(join(283136..284721,284773..284884)) V 1 NT_166531.1 Remark: similarity only to an internal part of beta transducin-like protein of P. anserina.; Title: weak similarity to hypothetical beta transducin-like protein - Podospora anserina; uncharacterized protein 284884 84593328 An16g01430 Aspergillus niger uncharacterized protein XP_059602699.1 283136 R 5061 CDS An16g01440 4988537 285336..286163 V 1 NT_166531.1 Title: similarity to hypothetical protein CAD21096.1 - Neurospora crassa; See PMID 9524204; uncharacterized protein 286163 4988537 An16g01440 Aspergillus niger uncharacterized protein XP_059602700.1 285336 D 5061 CDS An16g01450 4988538 join(286544..287126,287220..287635,287711..287909,287973..288188,288243..288532) V 1 NT_166531.1 Cofactor: FAD.; Function: Xl64phr of X. laevis repairs pyrimidine (6-4) pyrimidone photoproducts in the DNA which are caused by UV irradiation.; Remark: due to sequence similarity to the photolyase/blue-light photoreceptor family a function as photoreceptor can not be ruled out completely.; Remark: photolyases and blue light photoreceptors have similar sequences but different catalytic activities.; Similarity: Xl64phr belongs to the photolyase/blue-light photoreceptor family.; Title: strong similarity to 6-4 photolyase Xl64phr -Xenopus laevis; See PMID 9016626; See PMID 9810509; See PMID 10422537; uncharacterized protein 288532 4988538 An16g01450 Aspergillus niger uncharacterized protein XP_059602701.1 286544 D 5061 CDS An16g01460 4988539 join(289610..289907,289959..290080,290137..290733) V 1 NT_166531.1 Title: strong similarity to hypothetical protein encoded by An11g04970 - Aspergillus niger; uncharacterized protein 290733 4988539 An16g01460 Aspergillus niger uncharacterized protein XP_001397459.3 289610 D 5061 CDS An16g01470 4988540 complement(join(292991..295168,295221..299405)) V 1 NT_166531.1 Similarity: the ORF is arginine-rich and repetitive and both causes the high e-value. However, the ORF shows also some specific similarity to B7F21. 40 of N. crassa.; Title: similarity to hypothetical protein B7F21.40 -Neurospora crassa; uncharacterized protein 299405 4988540 An16g01470 Aspergillus niger uncharacterized protein XP_059602702.1 292991 R 5061 CDS An16g01480 4988541 join(301281..301508,301587..302486) V 1 NT_166531.1 Catalytic activity: Spermidine + [eIF-5A]-lysine <=> 1,3-diaminopropane + [eIF-5A]-deoxyhypusine; EC:1.1.1.249; Function:Deoxyhypusine synthase is an NAD(+)-dependent enzyme that catalyses the formation of a deoxyhypusine residue on the eukaryotic initiation factor 5A (eIF-5A) precursor by transferring an aminobutyl moiety from spermidine to the epsilon-amino group of a unique lysine residue.; Title: strong similarity to deoxyhypusine synthase -Neurospora crassa; See PMID 7592594; See PMID 8615810; uncharacterized protein 302486 4988541 An16g01480 Aspergillus niger uncharacterized protein XP_001397461.1 301281 D 5061 CDS An16g01490 4988542 join(304612..305020,305081..307174,307227..307971,308027..308603) V 1 NT_166531.1 Catalytic activity: Ubiquitin C-terminal thiolester + H2O = Ubiquitin + a Thiol; EC:3.1.2.15; Function: Protein acts on esters formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin. Also acts on AMP-ubiquitin.; Title: similarity to ubiquitin carboxyl-terminal hydrolase uch2p - Schizosaccharomyces pombe; See PMID 10872838; uncharacterized protein 308603 4988542 An16g01490 Aspergillus niger uncharacterized protein XP_001397462.1 304612 D 5061 CDS An16g01500 4988543 complement(309570..311858) V 1 NT_166531.1 Remark: Nop2p is an essential nucleolar protein in S. cerevisiae that is required for pre-rRNA processing and 60S ribosome subunit assembly in yeast.; Title: strong similarity to nucleolar protein Nop2 -Saccharomyces cerevisiae; nucleus; See PMID 7806561; See PMID 8972218; See PMID 9854021; uncharacterized protein 311858 4988543 An16g01500 Aspergillus niger uncharacterized protein XP_001397463.1 309570 R 5061 CDS An16g01510 4988544 join(312191..312301,312364..312886,312999..313006,313127..313181,313232..313431) V 1 NT_166531.1 Title: similarity to hypothetical protein B13N20.140 - Neurospora crassa; uncharacterized protein 313431 4988544 An16g01510 Aspergillus niger uncharacterized protein XP_059602703.1 312191 D 5061 CDS An16g01520 4988545 complement(join(314088..315967,316029..316287,316374..316613,317160..317170,317478..317574)) V 1 NT_166531.1 Localization: Zinedin is mainly expressed in the central nervous system; Remark: Zinedin is characterized by four protein-protein interaction domains, a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding domain, and a WD repeat domain, suggesting that it is a signaling or a scaffold protein. Protein binds calmodulin in the presence of Ca(2+).; Title: similarity to protein zinedin ZIN - Homo sapiens; See PMID 10748158; uncharacterized protein 317574 4988545 An16g01520 Aspergillus niger uncharacterized protein XP_059602704.1 314088 R 5061 CDS An16g01530 4988546 complement(join(317790..318235,318296..318926)) V 1 NT_166531.1 Remark: product: human downs syndrome critical region-like; Title: similarity to hypothetical protein SPAC22A12.13 - Schizosaccharomyces pombe; uncharacterized protein 318926 4988546 An16g01530 Aspergillus niger uncharacterized protein XP_001397466.1 317790 R 5061 CDS An16g01540 4988547 join(323726..323856,323955..324192,324233..325229,325280..325678,325734..326449) V 1 NT_166531.1 Similarity: strong similarity to S. pombe hypothetical protein SPAC24H6. 13, similarity to YOL084w,YLL005c and A. thaliana hyp1; Title: strong similarity to hypothetical membrane protein YMR266w - Saccharomyces cerevisiae; uncharacterized protein 326449 4988547 An16g01540 Aspergillus niger uncharacterized protein XP_059602705.1 323726 D 5061 CDS An16g01550 4988548 complement(join(327449..328588,328638..329536,329589..330231)) V 1 NT_166531.1 Title: strong similarity to hypothetical protein B23I11.160 - Neurospora crassa; uncharacterized protein 330231 4988548 An16g01550 Aspergillus niger uncharacterized protein XP_001397468.1 327449 R 5061 CDS An16g01560 4988549 join(331125..331210,331270..331929,332155..332579,332706..332941) V 1 NT_166531.1 Remark: GCD10 is an essential protein required in vivo for the initiation of total protein synthesis in S. cerevisiae.; Remark: alternate name in S. cerevisiae = YNL062C.; Title: strong similarity to protein Gcd10 -Saccharomyces cerevisiae; cytoplasm; See PMID 7542616; See PMID 10779558; uncharacterized protein 332941 4988549 An16g01560 Aspergillus niger uncharacterized protein XP_059602706.1 331125 D 5061 CDS An16g01570 4988550 complement(join(333298..333345,333404..333482,333553..333665,333773..334047,334167..334212,334280..334285)) V 1 NT_166531.1 Complex: protein belongs to a complex composed of arp2, arp3, p41-arc, p34-arc, p21-arc, p20-arc and p16-arc.; Function: part of the ARP2/3 complex implicated in the control of actin polymerization in cells.; Similarity: strong similarity to other p21-arc subunits.; Title: strong similarity to Arp2/3 complex 21kDa subunit ARC21 - Homo sapiens; See PMID 9230079; See PMID 10648568; See PMID 10801131; uncharacterized protein 334285 4988550 An16g01570 Aspergillus niger uncharacterized protein XP_001397470.1 333298 R 5061 CDS An16g01580 4988551 join(334588..334724,334780..334867,334932..335670,335742..335806) V 1 NT_166531.1 Remark: the yeast Arxula adeninivorans replication factor C (RF-C) is a multi-polypeptide complex with five sub-units involved in chromosomal DNA replication.; Title: strong similarity to replication factor C subunit ARFC3 - Arxula adeninivorans; See PMID 10022943; uncharacterized protein 335806 4988551 An16g01580 Aspergillus niger uncharacterized protein XP_059602707.1 334588 D 5061 CDS An16g01590 4988552 complement(join(336130..336750,336808..337330,337377..337577,337643..337728,337779..337967)) V 1 NT_166531.1 Remark: TOXA of Cochliobolus carbonum encodes an HC-toxin (host-selective cyclic tetrapeptide) efflux pump which contributes to self-protection against HC-toxin and/or the secretion of HC-toxin into the extracellular milieu.; Similarity: highly similar to several members of the major facilitator superfamily that confer resistance to tetracycline, methylenomycin, and other antibiotics.; Title: strong similarity to HC-toxin efflux pump TOXA - Cochliobolus carbonum; plasma membrane; See PMID 8704997; uncharacterized protein 337967 4988552 An16g01590 Aspergillus niger uncharacterized protein XP_001397472.1 336130 R 5061 CDS An16g01600 4988553 complement(join(338727..338768,339074..339124,339180..339512,339596..340317,340365..340443)) V 1 NT_166531.1 Function: probable uptake of sugars in the form of monosaccharides by the growing pollen tube.; Induction: Pmt1 of Petunia hybrida is activated after the first pollen mitosis, and high levels of mRNA accumulate in mature and germinating pollen; Title: similarity to monosaccharide transporter 1 pmt1 - Petunia hybrida; plasma membrane; See PMID 9733549; uncharacterized protein 340443 4988553 An16g01600 Aspergillus niger uncharacterized protein XP_059602708.1 338727 R 5061 CDS An16g01610 4988554 join(341581..341614,341669..341887,341943..343120) V 1 NT_166531.1 Catalytic activity: 4-Trimethylammoniobutanoate + 2-oxoglutarate + O2 = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2.; Cofactor: a reaction dependent on Fe2+,alpha-ketoglutarate, ascorbate and oxygen.; Function: gamma-butyrobetaine hydroxylase catalyses the last step in carnitine biosynthesis.; Title: weak similarity to gamma-butyrobetaine hydroxylase BBH - Rattus norvegicus; See PMID 10526231; See PMID 10709635; uncharacterized protein 343120 4988554 An16g01610 Aspergillus niger uncharacterized protein XP_001397474.1 341581 D 5061 CDS An16g01620 4988555 complement(join(343347..344556,344607..345055)) V 1 NT_166531.1 Catalytic activity: ATP + D-hexose = ADP + D-hexose 6-phosphate.; Remark: in addition to their catalytic role,hexokinases are thought to be involved in triggering carbon catabolite repression in Aspergillus nidulans.; Remark: mutations in the A. nidulans xprF and xprG genes have been shown to result in elevated levels of extracellular protease in response to carbon limitation in A. nidulans.; Title: strong similarity to hexokinase-like protein xprF - Aspergillus nidulans; See PMID 8628232; See PMID 11102357; uncharacterized protein 345055 4988555 An16g01620 Aspergillus niger uncharacterized protein XP_001397475.1 343347 R 5061 CDS An16g01630 4988556 join(345863..345985,346038..346060,346120..346239,346311..346870,346942..347147) V 1 NT_166531.1 Function: probably involved in lovastatin production.; Remark: polyketides, the ubiquitous products of secondary metabolism in microorganisms, are made by a process resembling fatty acid biosynthesis.; Remark: the lovastatin biosynthesis cluster contains two type I polyketide synthase genes in Aspergillus terreus.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994; uncharacterized protein 347147 4988556 An16g01630 Aspergillus niger uncharacterized protein XP_001397476.1 345863 D 5061 CDS An16g01640 4988557 complement(join(347340..347614,347688..348761,348811..349352,349412..349578)) V 1 NT_166531.1 Function: GAL4 of the yeast encodes a positive regulator of the galactose-inducible genes in S. cerevisiae.; Title: similarity to transcription factor Gal4 -Saccharomyces cerevisiae; nucleus; See PMID 6366516; uncharacterized protein 349578 4988557 An16g01640 Aspergillus niger uncharacterized protein XP_059602709.1 347340 R 5061 CDS An16g01650 4988558 join(350030..350122,350184..350858) V 1 NT_166531.1 Catalytic activity: scytalone + NADP+ = 1,3,6,8-tetrahydroxynaphthalene + NADPH.; Pathway: involved in the biosynthesis of melanin in pathogenic fungi (together with scytalone dehydratase).; Remark: abr2 has homology to the laccase encoded by the yA gene of Aspergillus nidulans.; Similarity: arp2 has a high similarity to hydroxynaphthalene reductases found in the dihydroxynaphthalene (DHN)-melanin pathway of brown and black fungi.; Title: strong similarity to 1,3,6,8-tetrahydroxynaphthalene reductase arp2 - Aspergillus fumigatus; See PMID 10515939; uncharacterized protein 350858 4988558 An16g01650 Aspergillus niger uncharacterized protein XP_001397478.1 350030 D 5061 CDS An16g01660 4988559 join(351773..353120,353182..353226,353276..353415) V 1 NT_166531.1 Remark: fluconazole-resistant strains exhibit increased expression of multidrug resistance transporters,especially MDR1 in Candida dubliniensis.; Similarity: C. dubliniensis encodes multidrug transporters similar to those encoded by the C. albicans MDR1, CDR1, and CDR2 genes (CaMDR1, CaCDR1, and CaCDR2,respectively).; Title: strong similarity to multidrug resistance protein MDR1 - Candida dubliniensis; plasma membrane; See PMID 9661028; See PMID 9986880; uncharacterized protein 353415 4988559 An16g01660 Aspergillus niger uncharacterized protein XP_001397479.1 351773 D 5061 CDS An16g01670 4988560 complement(join(353885..354814,354877..354996)) V 1 NT_166531.1 Catalytic activity: dimethylallyl diphosphate + isopentenyl diphosphate <=> diphosphate + geranyl diphosphate.; Catalytic activity: geranyl diphosphate + isopentenyl diphosphate <=> diphosphate + trans,trans-farnesyl diphosphate.; Remark: the peptide chain of the farnesyl-pyrophosphate synthetase FPPS from Gibberella fujikuroi carries two activities.; Title: strong similarity to farnesyl-pyrophosphate synthase FPPS - Gibberella fujikuroi; See PMID 8753652; uncharacterized protein 354996 4988560 An16g01670 Aspergillus niger uncharacterized protein XP_001397480.1 353885 R 5061 CDS An16g01680 4988561 complement(join(355276..355347,355385..355532,355582..355698,355789..355982,356118..356738)) V 1 NT_166531.1 Catalytic activity: RX + glutathione <=> HX + R-S-glutathione.; Complex: the gluthathione S-transferase III from Zea mays forms a homodimer.; Function: the gluthathione S-transferase III from Zea mays conjugates reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and is involved in the detoxification of certain herbicides.; Remark: the ORF encoded protein is C-terminal longer than all homologues, this could be caused by an incorrect stopcodon due to a putative sequencing error.; Title: strong similarity to gluthathione S-transferase III GST3 - Zea mays; See PMID 3277162; See PMID 3532034; uncharacterized protein 356738 4988561 An16g01680 Aspergillus niger uncharacterized protein XP_001397481.3 355276 R 5061 CDS An16g01690 4988562 complement(join(358361..359093,359124..359851)) V 1 NT_166531.1 Remark: XPCT is subject to X chromosome inactivation, being expressed only from the active X in human.; Title: similarity to X-linked PEST-containing monocarboxylate transporter XPCT - Homo sapiens; plasma membrane; See PMID 9425115; uncharacterized protein 359851 4988562 An16g01690 Aspergillus niger uncharacterized protein XP_059602710.1 358361 R 5061 CDS An16g01700 84593329 complement(join(361283..361615,361677..361823)) V 1 NT_166531.1 Catalytic activity: L-iditol + NAD(+) <=> L-sorbose + NADH.; Remark: next ORF also shows similarities to L-iditol 2-dehydrogenases.; Similarity: the ORF encoded protein only shows strong similarity to the n-terminal part of L-iditol 2-dehydrogenases. The ORF encoded protein (159aa) is shorter than the known L-iditol 2-dehydrogenases (347aa S. pombe).; Title: similarity to L-iditol 2-dehydrogenase (sorbitol dehydrogenase) tms1p - Schizosaccharomyces pombe; See PMID 8223615; uncharacterized protein 361823 84593329 An16g01700 Aspergillus niger uncharacterized protein XP_059602711.1 361283 R 5061 CDS An16g01710 4988564 join(362195..362462,362589..363055,363133..363408) V 1 NT_166531.1 Catalytic activity: L-iditol + NAD(+) <=> L-sorbose + NADH.; Function: also catalyzes the oxidation by NAD+ of sorbitol to fructose.; Remark: previous ORF also shows similarities to L-iditol 2-dehydrogenases.; Title: strong similarity to L-iditol 2-dehydrogenase (sorbitol dehydrogenase) SORD - Homo sapiens; See PMID 7782086; See PMID 8088829; uncharacterized protein 363408 4988564 An16g01710 Aspergillus niger uncharacterized protein XP_059602712.1 362195 D 5061 CDS An16g01720 4988565 complement(join(363679..364057,364113..364168,364226..364310,364360..364556,364610..364714,364781..364927,364986..365054)) V 1 NT_166531.1 Catalytic activity: an alcohol + NADP(+) <=> an aldehyde + NADPH.; Title: strong similarity to aldehyde reductase ALR1 - Sus scrofa; See PMID 7484379; See PMID 9329083; uncharacterized protein 365054 4988565 An16g01720 Aspergillus niger uncharacterized protein XP_059602713.1 363679 R 5061 CDS An16g01730 4988566 366773..368203 V 1 NT_166531.1 Catalytic activity: an orthophosphoric monoester + H2O = an alcohol + orthophosphate.; Remark: acid phosphatases have wide specificity,also calyses transphosphorylations.; Title: similarity to acid phosphatase precursor rPAP - Rattus norvegicus; See PMID 4563528; uncharacterized protein 368203 4988566 An16g01730 Aspergillus niger uncharacterized protein XP_001397486.1 366773 D 5061 CDS An16g01740 4988567 join(368844..369238,369293..369877,369931..369976) V 1 NT_166531.1 Title: strong similarity to hypothetical protein encoded by An14g02280 - Aspergillus niger; uncharacterized protein 369976 4988567 An16g01740 Aspergillus niger uncharacterized protein XP_001397487.1 368844 D 5061 CDS An16g01750 4988568 370421..372154 V 1 NT_166531.1 Catalytic activity: peptidylproline (omega=180) <=> peptidylproline (omega=0).; Function: peptidyl-prolyl cis-trans isomerases accelerate the folding of proteins.; Remark: cyclophilin isoform 4 from C. elegans is involved in cis-trans isomerization of proline imidic peptide bonds in oligopeptides.; Title: similarity to peptidyl-prolyl cis-trans isomerase 4 cyp-4 - Caenorhabditis elegans; See PMID 8694762; uncharacterized protein 372154 4988568 An16g01750 Aspergillus niger uncharacterized protein XP_001397488.1 370421 D 5061 CDS An16g01760 4988569 complement(join(372930..374853,374911..375377)) V 1 NT_166531.1 Function: the S. pombe HSF transcription factor binds to heat shock promoter elements and activates transcription of heat shock genes.; Title: similarity to heat shock transcription factor HSF - Schizosaccharomyces pombe; nucleus; See PMID 8423799; See PMID 9675818; See PMID 1986225; uncharacterized protein 375377 4988569 An16g01760 Aspergillus niger uncharacterized protein XP_001397489.1 372930 R 5061 CDS An16g01770 4988570 complement(join(376628..377314,377397..377663)) V 1 NT_166531.1 Function: the NAD(P)H-dependent yylose reductase from Pachysolen tannophilus reduces xylose into xylitol.; Pathway: the NAD(P)H-dependent xylose reductase from Pachysolen tannophilus is involved in D-xylose degradation.; Title: similarity to NAD(P)H-dependent xylose reductase XYL1 - Pachysolen tannophilus; See PMID 8923742; uncharacterized protein 377663 4988570 An16g01770 Aspergillus niger uncharacterized protein XP_001397490.1 376628 R 5061 CDS An16g01780 4988571 join(378991..379294,379348..379631) V 1 NT_166531.1 Expression: this gene is expressed during appressorium formation by Colletotrichum gloeosporioides conidia.; Induction: the expression of CAP22 gene from Colletotrichum gloeosporioides is induced by the host (avocado fruit) surface wax.; Remark: appressorien are short specialized hyphas,which are used by fungi as holdfasts at the host surfaces.; Title: similarity to protein CAP22 - Colletotrichum gloeosporioides; See PMID 7770033; uncharacterized protein 379631 4988571 An16g01780 Aspergillus niger uncharacterized protein XP_001397491.1 378991 D 5061 CDS An16g01790 84593330 join(381628..381686,381902..382373) V 1 NT_166531.1 Remark: collagen-like protein which is a epithelial surface receptor in pathogen fungi.; Title: similarity to fibronectin-binding protein sfs - Streptococcus equi; See PMID 3326135; uncharacterized protein 382373 84593330 An16g01790 Aspergillus niger uncharacterized protein XP_059602714.1 381628 D 5061 CDS An16g01800 4988573 join(384804..385145,385211..385754,385793..386754) V 1 NT_166531.1 Title: strong similarity to hypothetical protein YBL051c - Saccharomyces cerevisiae; uncharacterized protein 386754 4988573 An16g01800 Aspergillus niger uncharacterized protein XP_059602715.1 384804 D 5061 CDS An16g01810 4988574 complement(join(388890..389137,389221..389290,389646..389744)) V 1 NT_166531.1 Function: the histone H2A variant encoded by the pht1 gene in S. pombe is important for chromosomal structure and function, possibly including a role in controlling the fidelity of chromosomal segregation during mitosis.; Title: strong similarity to histone H2A variant pht1p - Schizosaccharomyces pombe; uncharacterized protein 389744 4988574 An16g01810 Aspergillus niger uncharacterized protein XP_001397494.1 388890 R 5061 CDS An16g01820 4988575 join(390713..390729,390835..390995,391053..391434,391653..391704) V 1 NT_166531.1 Title: strong similarity to hypothetical inorganic phosphate transporter and regulator of Pho81p Pho88 -Saccharomyces cerevisiae; See PMID 8709965; uncharacterized protein 391704 4988575 An16g01820 Aspergillus niger uncharacterized protein XP_059602716.1 390713 D 5061 CDS An16g01830 4988576 join(393594..393605,393681..393716,393776..393789,393891..393954,394030..394714,394771..394941,395001..395029) V 1 NT_166531.1 Catalytic activity: D-glyceraldehyde 3-phosphate + phosphate + NAD(+) <=> 3-phospho-D-glyceroyl phosphate + NADH; Gene-ID: gpdA;gpd; Mapping: gpdA from A. niger is mapped to chromosome V; see list from DSM, EMBL X99652.; Remark: a splice site was detected upstream of the START codon.; Remark: also acts very slowly on D-glyceraldehyde and some other aldehydes. Thiols can replace phosphate.; Similarity: identical to glyceraldehyde-3-phosphate dehydrogenase of Aspergillus niger.; glyceraldehyde-3-phosphate dehydrogenase gpdA-Aspergillus niger 395029 gpdA 4988576 gpdA Aspergillus niger glyceraldehyde-3-phosphate dehydrogenase gpdA-Aspergillus niger XP_001397496.1 393594 D 5061 CDS An16g01840 4988577 join(396133..396772,396824..397112,397298..397368,397546..397706,397756..397966,398010..398121,398165..398212,398263..398326,398372..398464,398514..398599,398649..398728,398777..398883,398940..399212) V 1 NT_166531.1 Function: Hda1p of S. cerevisiae is involved in telomeric silencing and transcriptional regulation.; Function: Hda1p of S. cerevisiae is subunit of the HDA complex involved in histone deacetylation.; Remark: the systematic gene name of S. cerevisiae HDA1 is YNL021w.; Title: strong similarity to histone deacetylase A Hda1 - Saccharomyces cerevisiae; nucleus; See PMID 10856249; See PMID 8663039; See PMID 8962081; uncharacterized protein 399212 4988577 An16g01840 Aspergillus niger uncharacterized protein XP_059602717.1 396133 D 5061 CDS An16g01850 4988578 400441..400920 V 1 NT_166531.1 Function: bys1 in B. dermatitidis is expressed at very high levels in the yeast phase but whose levels diminish rapidly when yeast cells are transferred to 25 degrees C to promote conversion to the mycelial phase.; Remark: synonymous name of Ajellomyces dermatitidis is Blastomyces dermatitidis.; Title: similarity to blastomyces yeast phase-specific protein 1 bys1 - Ajellomyces dermatitidis; See PMID 8188377; uncharacterized protein 400920 4988578 An16g01850 Aspergillus niger uncharacterized protein XP_001397498.1 400441 D 5061 CDS An16g01860 4988579 join(402143..402625,402703..402802,402866..405786) V 1 NT_166531.1 EC:3.4.99.-; Similarity: shows also strong similarity to human and rat insulin degrading enzyme, and to several other zinc proteases from different sources.; Title: strong similarity to protease involved in a-factor processing Ste23 - Saccharomyces cerevisiae; uncharacterized protein 405786 4988579 An16g01860 Aspergillus niger uncharacterized protein XP_001397499.3 402143 D 5061 CDS An16g01870 4988580 join(406223..406263,406337..406588,406644..406891,406966..407258) V 1 NT_166531.1 Complex: in human, three major polypeptides of 25,59, and 68 kD and a less abundant polypeptide of 72 kD have been shown to copurify with CF Im (CFIM) activity.; Function: cleavage factors (CFs) Im and IIm, both of which are required in order for cleavage and polyadenylation to occur, are involved in the first step of 3'- processing.; Function: modifications include the generation of a new 3'-end by endonucleolytic cleavage followed by polyadenylation of the upstream cleavage product.; Function: most eukaryotic mRNA primary transcripts are processed both internally and at their termini in the nucleus, before they are exported to the cytoplasm.; Title: strong similarity to mRNA cleavage factor I 25 kDa subunit CFIM25 - Homo sapiens; See PMID 9659921; uncharacterized protein 407258 4988580 An16g01870 Aspergillus niger uncharacterized protein XP_001397500.1 406223 D 5061 CDS An16g01880 4988581 join(409372..409453,409508..409673,409719..410055,410107..410415) V 1 NT_166531.1 Similarity: sequence is almost identical to sequence 1 from Patent WO9831790, where the protein is described having a phospholipase activity.; Title: strong similarity to lysophospholipase -Aspergillus foetidus; uncharacterized protein 410415 4988581 An16g01880 Aspergillus niger uncharacterized protein XP_001397501.1 409372 D 5061 CDS An16g01890 4988582 join(410951..411342,411398..411840,411894..412102) V 1 NT_166531.1 Title: strong similarity to hypothetical protein encoded by An14g02280 - Aspergillus niger; uncharacterized protein 412102 4988582 An16g01890 Aspergillus niger uncharacterized protein XP_001397502.1 410951 D 5061 CDS An16g01900 4988583 complement(join(413344..413836,413892..414007)) V 1 NT_166531.1 Title: similarity to hypothetical protein encoded by An04g06980 - Aspergillus niger; uncharacterized protein 414007 4988583 An16g01900 Aspergillus niger uncharacterized protein XP_001397503.3 413344 R 5061 CDS An16g01910 84593331 join(414723..414758,414871..415146) V 1 NT_166531.1 hypothetical protein 415146 84593331 An16g01910 Aspergillus niger hypothetical protein XP_059602718.1 414723 D 5061 CDS An16g01920 4988585 complement(join(416043..416477,416541..416866,416918..417334,417377..417459,417512..417625,417676..417746,417798..417848)) V 1 NT_166531.1 Function: gabA of A. nidulans is subject to carbon catabolite and nitrogen metabolite repression, omega-amino acid induction and regulation in response to ambient pH (being acid-expressed).; Similarity: shows also similarity to several putative fungal amino acid permeases.; Title: strong similarity to GABA permease gabA -Aspergillus nidulans; See PMID 10320578; uncharacterized protein 417848 4988585 An16g01920 Aspergillus niger uncharacterized protein XP_059602719.1 416043 R 5061 CDS An16g01930 4988586 join(419030..419124,419245..419419,419465..419560) V 1 NT_166531.1 hypothetical protein 419560 4988586 An16g01930 Aspergillus niger hypothetical protein XP_001397506.3 419030 D 5061 CDS An16g01940 4988587 complement(join(419665..419689,419746..419829,419885..420003,420057..420900,420952..421280,421333..421599)) V 1 NT_166531.1 Similarity: shows similarity to several probable transporter proteins of different species.; Title: similarity to allantoate permease Dal5 -Saccharomyces cerevisiae; See PMID 10869563; uncharacterized protein 421599 4988587 An16g01940 Aspergillus niger uncharacterized protein XP_001397507.1 419665 R 5061 CDS An16g01950 4988588 join(423185..423390,423441..423646,423702..424156,424288..424437,424492..424605) V 1 NT_166531.1 Function: disruption of the YLL057c of S. cerevisiae encoding this enzyme negatively affects the use of isethionate and taurine as sulfur sources by S. cerevisiae,providing strong evidence that YLL057c plays a role in sulfonate catabolism.; Function: purified recombinant protein of YLL057c of S. cerevisiae is shown to be an Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase; although taurine is a poor substrate, a variety of other sulfonates are utilized, with the best natural substrates being isethionate and taurocholate.; Title: strong similarity to Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase YLL057c -Saccharomyces cerevisiae; See PMID 10482536; uncharacterized protein 424605 4988588 An16g01950 Aspergillus niger uncharacterized protein XP_059602720.1 423185 D 5061 CDS An16g01960 4988590 complement(join(424865..425269,425773..425934,426028..>426279)) V 1 NT_166531.1 hypothetical protein [truncated ORF] 426279 4988590 An16g01960 Aspergillus niger hypothetical protein [truncated ORF] XP_001397510.3 424865 R 5061 CDS An16g01970 84593332 complement(<426676..427515) V 1 NT_166531.1 Similarity: the similarity of the ORF to the hypothetical protein SPBC1734. 10c of S. pombe is restricted to the inner part, reaching from amino acid 129 to 180.; Title: similarity to hypothetical protein SPBC1734.10c - Schizosaccharomyces pombe; uncharacterized protein 427515 84593332 An16g01970 Aspergillus niger uncharacterized protein XP_059606742.1 426676 R 5061 CDS An16g01980 4988591 complement(join(427906..428440,428500..429227)) V 1 NT_166531.1 Title: similarity to hypothetical protein PA1213 -Pseudomonas aeruginosa; uncharacterized protein 429227 4988591 An16g01980 Aspergillus niger uncharacterized protein XP_059606743.1 427906 R 5061 CDS An16g01990 4988592 complement(join(429798..430552,430609..430736,430790..430935,430983..431183)) V 1 NT_166531.1 Title: similarity to hypothetical protein B18D24.50 - Neurospora crassa; uncharacterized protein 431183 4988592 An16g01990 Aspergillus niger uncharacterized protein XP_001397512.1 429798 R 5061 CDS An16g02000 4988593 complement(join(431724..431887,431957..432035,432092..432239,432295..432501,432549..432750,432800..432905,432958..432986,433037..433071,433123..433201,433255..433369,433422..433493,433541..433563,433728..433756,433805..433877,433995..434064,434165..434198,434283..434323)) V 1 NT_166531.1 Catalytic activity: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.; Remark: gabA of A. nidulans has 19 introns, an unusually large number of introns for fungal genes.; Remark: gabA of A. nidulans is subject to carbon catabolite and nitrogen metabolite repression, omega-amino acid induction and regulation in response to ambient pH (being acid-expressed).; Title: strong similarity to GABA permease gabA -Aspergillus nidulans; See PMID 10320578; uncharacterized protein 434323 4988593 An16g02000 Aspergillus niger uncharacterized protein XP_059606744.1 431724 R 5061 CDS An16g02010 4988594 complement(join(435643..436111,436171..440171)) V 1 NT_166531.1 Function: PEX1 and PEX6 of P. chrysogenum encode proteins of the AAA family of ATPases.; Function: PEX6 of P. chrysogenum is involved in peroxisome biogenesis.; Function: the peroxisome biogenesis factors Pex4p,Pex22p, Pex1p, and Pex6p of P. chrysogenum act in the terminal steps of peroxisomal matrix protein import.; Title: strong similarity to peroxin-6 PEX6 -Penicillium chrysogenum; peroxisome; See PMID 10968639; See PMID 11003648; uncharacterized protein 440171 4988594 An16g02010 Aspergillus niger uncharacterized protein XP_059606745.1 435643 R 5061 CDS An16g02020 4988595 complement(join(440849..441229,441297..441538,441612..441884,441945..442122,442151..442203,442264..442653,442700..442723,442774..442870,442923..443261)) V 1 NT_166531.1 Function: A. terreus dihydrogeodin oxidase (DHGO) is an enzyme catalyzing the stereospecific phenol oxidative coupling reaction converting dihydrogeodin to (+)-geodin.; Function: the phenol oxidative coupling reaction is involved in the biosynthesis of a wide range of natural products such as alkaloids (e. g. morphine, lycorine),lignans, and other phenolic compounds (e. g. usunic acid,griseofulvin).; Remark: putative sequencing errors have caused wrong gene prediction and perhapes also some other problems with the sequence.; Similarity: shows significant homology with other multicopper blue proteins such as laccase and ascorbate oxidase.; Title: strong similarity to dihydrogeodin oxidase DHGO - Aspergillus terreus [putative sequencing error]; uncharacterized protein 443261 4988595 An16g02020 Aspergillus niger uncharacterized protein XP_059606746.1 440849 R 5061 CDS An16g02030 84593333 complement(join(444741..445165,445203..445443)) V 1 NT_166531.1 hypothetical protein 445443 84593333 An16g02030 Aspergillus niger hypothetical protein XP_059606747.1 444741 R 5061 CDS An16g02040 4988597 join(449325..449829,449887..450152,450207..450415,450467..450739,450789..451755) V 1 NT_166531.1 Function: H. jecorina ACEI protein is DNA-binding; contains a nuclear localization signal; is a activator; binds to cbh1 promoter involved in cellulase regulator.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to Cys2-His2 zinc finger transcription factor ACEI - Hypocrea jecorina; nucleus; See PMID 10681571; uncharacterized protein 451755 4988597 An16g02040 Aspergillus niger uncharacterized protein XP_001397517.3 449325 D 5061 CDS An16g02050 84593334 complement(join(453534..453653,453755..453772)) V 1 NT_166531.1 hypothetical protein 453772 84593334 An16g02050 Aspergillus niger hypothetical protein XP_059606748.1 453534 R 5061 CDS An16g02060 4988599 join(455484..455658,455705..456567) V 1 NT_166531.1 Title: similarity to hypothetical protein Pa5D0029 -Podospora anserina; uncharacterized protein 456567 4988599 An16g02060 Aspergillus niger uncharacterized protein XP_059606749.1 455484 D 5061 CDS An16g02070 4988600 complement(join(456701..456937,457030..457893)) V 1 NT_166531.1 Similarity: shows only partial similarity to human ANG2 protein.; Title: similarity to hypothetical protein ANG2 -Homo sapiens; uncharacterized protein 457893 4988600 An16g02070 Aspergillus niger uncharacterized protein XP_059606750.1 456701 R 5061 CDS An16g02080 4988601 <458211..458924 V 1 NT_166531.1 Title: similarity to hypothetical protein SPAC26A3.03c - Schizosaccharomyces pombe; uncharacterized protein 458924 4988601 An16g02080 Aspergillus niger uncharacterized protein XP_001397521.1 458211 D 5061 CDS An16g02090 4988602 complement(join(459038..462971,463028..463228,463289..463404)) V 1 NT_166531.1 Function: Ski2p, Ski3p, and Ski8p of S. cerevisiae inhibit translation of poly(A)- mRNA.; Function: Ski3p of S. cerevisiae controls propagation of M dsRNA virus through regulation of M dsRNA synthesis.; Function: Ski3p of S. cerevisiae is essential for protection against viral propagation.; Function: Ski3p of S. cerevisiae is part of a system to protect cells from dsRNA viruses.; Function: Ski3p of S. cerevisiae represses copy number of M1 dsRNA which encodes killer toxin.; Function: Ski3p of S. cerevisiae works together with Ski8p, probably through interaction of TRP and beta-transducin(WD-40) motifs.; Similarity: TPR domain-containing protein.; Title: strong similarity to antiviral protein Ski3 -Saccharomyces cerevisiae; See PMID 9482746; uncharacterized protein 463404 4988602 An16g02090 Aspergillus niger uncharacterized protein XP_001397522.1 459038 R 5061 CDS An16g02100 4988603 join(463989..464372,464431..465362,465411..465729,465800..466453) V 1 NT_166531.1 Title: strong similarity to hypothetical protein YIR007w - Saccharomyces cerevisiae; uncharacterized protein 466453 4988603 An16g02100 Aspergillus niger uncharacterized protein XP_001397523.1 463989 D 5061 CDS An16g02110 84593335 466870..467397 V 1 NT_166531.1 Remark: the sequence contains two putative sequencing errors.; Remark: this ORF was recognized by blastx analysis of the intergenic region of preceding and next ORF.; Remark: unfortunately the match against A. thaliana APG5 protein cannot be found using blastp.; Title: weak similarity to arabinogalactan-protein AGP5 - Arabidopsis thaliana [putative sequencing error]; putative sequencing error; uncharacterized protein 467397 84593335 An16g02110 Aspergillus niger uncharacterized protein XP_059606751.1 466870 D 5061 CDS An16g02120 4988605 join(467463..468290,468357..468545,468600..469071,469121..469289,469402..469651,469702..469805,469854..470112,470162..470304,470354..470952,471014..471690) V 1 NT_166531.1 Function: Msn5p of S. cerevisiae belongs to a family of proteins with a conserved N-terminal sequence that acts as a RanGTP-binding domain.; Function: Msn5p of S. cerevisiae is involved in several different signal transduction pathways.; Function: Msn5p of S. cerevisiae is suppossed to be a import or export receptor that interacts with the small GTPase Ran involved in the transport through the nuclear envelope.; Function: Msn5p of S. cerevisiae participates in processes such as catabolite repression, calcium signaling,mating, and cell proliferation, as well as being involved in previously characterized phosphate utilization.; Title: strong similarity to nuclear transport receptor Msn5 - Saccharomyces cerevisiae; See PMID 10545454; uncharacterized protein 471690 4988605 An16g02120 Aspergillus niger uncharacterized protein XP_059606752.1 467463 D 5061 CDS An16g02130 4988606 complement(join(472198..472246,472320..472503,472601..472646,472782..472832)) V 1 NT_166531.1 Function: murine protein is involved in cell death in response to IFN/RA.; Localization: murine GRIM19 is localized in the nucleus.; Title: similarity to novel cell death-regulatory protein GRIM19 - Mus musculus; See PMID 10924506; uncharacterized protein 472832 4988606 An16g02130 Aspergillus niger uncharacterized protein XP_059606753.1 472198 R 5061 CDS An16g02140 4988607 473187..474437 V 1 NT_166531.1 Title: strong similarity to hypothetical protein SPAC6B12.09 - Schizosaccharomyces pombe; uncharacterized protein 474437 4988607 An16g02140 Aspergillus niger uncharacterized protein XP_001397527.1 473187 D 5061 CDS An16g02150 4988608 join(474957..474975,475155..476716,476770..477588) V 1 NT_166531.1 Title: strong similarity to hypothetical protein SPBC1685.14c - Schizosaccharomyces pombe; uncharacterized protein 477588 4988608 An16g02150 Aspergillus niger uncharacterized protein XP_001397528.1 474957 D 5061 CDS An16g02160 4988609 complement(join(477926..477932,478100..478228,478287..478369,478532..479221)) V 1 NT_166531.1 Similarity: the C-terminal end, beginning with amino acid 100 of the predicted ORF, shows similarities to proteins probably involved in oxidation protection of genes, e. g. L82 of D. melanogaster and oxr1 of H. sapiens.; Title: strong similarity to hypothetical protein YPL196w - Saccharomyces cerevisiae; See PMID 11237729; uncharacterized protein 479221 4988609 An16g02160 Aspergillus niger uncharacterized protein XP_059606754.1 477926 R 5061 CDS An16g02170 4988610 complement(join(479617..479700,479755..479919,479983..480103,480161..480350,480398..480406,480456..480728,480789..480922,480975..481195)) V 1 NT_166531.1 Function: hyl1 of A. niger hydrolyses 4-nitrostyrene epoxide and other epoxides.; Gene-ID: hyl1; Similarity: the predicted ORF overlaps with A. niger ESTs BE759060 and BE760406.; Similarity: the sequence of the A. niger clone could encode an unpublished allelic product.; See PMID 10548561; See PMID 10673439; epoxide hydrolase hyl1-Aspergillus niger 481195 hyl1 4988610 hyl1 Aspergillus niger epoxide hydrolase hyl1-Aspergillus niger XP_001397530.1 479617 R 5061 CDS An16g02180 4988611 complement(481993..482985) V 1 NT_166531.1 Remark: the predicted ORF is probably a member of the short chain dehydrogenase/reductase (sdr) family.; Similarity: the predicted ORF shows similarities to some dehydrogenases of different species.; Title: strong similarity to hypothetical short chain dehydrogenase SPCC736.13 - Schizosaccharomyces pombe; uncharacterized protein 482985 4988611 An16g02180 Aspergillus niger uncharacterized protein XP_001397531.1 481993 R 5061 CDS An16g02190 4988612 483577..484182 V 1 NT_166531.1 Catalytic activity: proline racemaces catalyse the reaction L-proline <=> D-proline.; Similarity: the predicted ORF shows strong similarity to the central part of proline racemase prdF from C. sticklandii reaching from amino acid 54 to 245 of the 299 amino acids long protein.; Title: strong similarity to proline racemase prdF -Clostridium sticklandii; See PMID 10085076; See PMID 3718964; uncharacterized protein 484182 4988612 An16g02190 Aspergillus niger uncharacterized protein XP_001397532.3 483577 D 5061 CDS An16g02200 4988613 join(484570..484772,484836..485895) V 1 NT_166531.1 Title: similarity to hypothetical protein YBR246w -Saccharomyces cerevisiae; uncharacterized protein 485895 4988613 An16g02200 Aspergillus niger uncharacterized protein XP_001397533.1 484570 D 5061 CDS An16g02210 4988614 complement(join(486075..486353,486416..486973)) V 1 NT_166531.1 Function: rpn12 of S. cerevisiae is a component of the 19S regulatory particle of the proteasome and is therefore involved in ubiquitin-dependent protein degradation.; Phenotype: the null mutant of rpn12 of S. cerevisiae is inviable and the nin1-1 mutant is a temperature-sensitive mutant that shows i) higher rates of recombination and chromosome and plasmid loss; ii) greater sensitivity to UV irradiation; iii) at restrictive temperature, arrest in G2 phase, failure to activate histone H1 kinase, and accumulation of polyubiquinated proteins.; Remark: rpn12 is also called nin1.; Similarity: the predicted ORF overlaps with A. niger EST BE759311.; Title: strong similarity to proteasome 19S regulatory particle subunit Rpn12 - Saccharomyces cerevisiae; See PMID 8143766; See PMID 9584156; See PMID 1563492; uncharacterized protein 486973 4988614 An16g02210 Aspergillus niger uncharacterized protein XP_001397534.1 486075 R 5061 CDS An16g02220 84593336 complement(join(487275..487639,487677..487792,487899..488115,488270..488350,488611..488764,488803..488861,488919..489090)) V 1 NT_166531.1 Similarity: the similarity of the predicted ORF to the putative 6-hydroxy-D-nicotine oxidase related protein 13E11. 250 of N. crassa is restricted to the C-terminal end of the N. crassa sequence, starting with amino acid 428.; Title: weak similarity to hypothetical 6-hydroxy-D-nicotine oxidase related protein 13E11.250 -Neurospora crassa; uncharacterized protein 489090 84593336 An16g02220 Aspergillus niger uncharacterized protein XP_059606755.1 487275 R 5061 CDS An16g02230 4988616 join(490108..490544,490586..492605) V 1 NT_166531.1 Function: co-expression of het-e and het-c lead to cell death.; Function: het-e1 of P. anserina is responsible for vegetative incompatibility.; Remark: het-e1 of P. anserina shows also two sequence motifs, a GTP-binding domain and a repeated region that shares similarity with that of the beta-transducin.; Remark: the reactivity of the HET-E protein depends on two functional elements, a GTP-binding domain and several WD40 repeats.; Similarity: the predicted ORF shows much stronger similarity to the hypothetical protein B24M22. 200 of N. crassa.; Title: similarity to beta transducin-like protein het-e1 - Podospora anserina; See PMID 9435787; See PMID 10875280; See PMID 10974123; See PMID 7557402; uncharacterized protein 492605 4988616 An16g02230 Aspergillus niger uncharacterized protein XP_059606756.1 490108 D 5061 CDS An16g02240 4988617 complement(493100..494041) V 1 NT_166531.1 Catalytic activity: PT1 of P. taeda catalyzes the reduction of the benzylic ether bond of dehydrodiconiferyl alcohol and dihydrodehydrodiconiferyl alcohol to produce,respectively, isodihydrodehydrodiconyferyl alcohol and tetrahydrodehydrodiconiferyl alcohol.; Function: these compounds, as many other phenylpropanoids, are crucial for plant defense mechanisms,especially against fungal infections.; Similarity: a weaker similarity exists to putative and described oxidoreductases.; Similarity: the predicted ORF shows strong similarity to several hypothetical proteins with no known function.; Title: similarity to phenylcoumaran benzylic ether reductase PT1 - Pinus taeda; See PMID 10066819; uncharacterized protein 494041 4988617 An16g02240 Aspergillus niger uncharacterized protein XP_001397537.1 493100 R 5061 CDS An16g02250 4988618 complement(join(494567..494846,494903..495417,495463..496389)) V 1 NT_166531.1 Catalytic activity: CLN2 of H. sapiens encodes the lysosomal tripeptidyl peptidase I, an enzyme that that cleaves tripeptides from the N-terminus of polypeptides,but has also an endopeptidase activity.; Phenotype: deficiency of CLN2 in humans causes classical late infantile neuronal ceroid lipofuscinosis (LINCL), a fatal childhood neurodegenerative disease.; Similarity: CLN2 of H. sapiens and the predicted ORF show significant sequence similarity to prokaryotic pepstatin-insensitive acid proteases.; Title: strong similarity to lysosomal pepstatin insensitive protease CLN2 - Homo sapiens; lysosome; See PMID 9653647; See PMID 9989590; See PMID 10428067; See PMID 10679303; uncharacterized protein 496389 4988618 An16g02250 Aspergillus niger uncharacterized protein XP_059606757.1 494567 R 5061 CDS An16g02260 84593337 join(496712..496786,496936..497049,497214..497468) V 1 NT_166531.1 Title: weak similarity to hypothetical cDNA FLJ20093 fis - Homo sapiens; uncharacterized protein 497468 84593337 An16g02260 Aspergillus niger uncharacterized protein XP_059606758.1 496712 D 5061 CDS An16g02270 84593338 complement(join(498557..498609,498654..498759)) V 1 NT_166531.1 hypothetical protein 498759 84593338 An16g02270 Aspergillus niger hypothetical protein XP_059606759.1 498557 R 5061 CDS An16g02280 4988621 complement(join(499772..499850,499964..500341,500403..500576,500628..501244,501304..501384,501442..501752,501835..502243,502296..502394)) V 1 NT_166531.1 Similarity: although the predicted ORF shows similarity to many fungal transcription factors, it does not contain the typical Zn(2)-Cys(6) fungal-type binuclear cluster domain, responsible for DNA binding of these proteins.; Similarity: the predicted ORF contains, instead,three leucine zipper domains, typical of other gene regulatory proteins.; Title: similarity to cutinase transcription factor beta CTF1b - Fusarium solani; nucleus; See PMID 9139694; uncharacterized protein 502394 4988621 An16g02280 Aspergillus niger uncharacterized protein XP_059606760.1 499772 R 5061 CDS An16g02290 4988622 complement(join(503151..503763,503833..504023)) V 1 NT_166531.1 Complex: ECI1 of S. cerevisiae is a homohexamer.; Function: ECI1 of S. cerevisiae acts as an auxiliary enzyme in the beta-oxidation of (poly)unsaturated fatty acids, converting 3-hexenoyl-CoA to trans-2-hexenoyl-CoA.; Induction: ECI1 transcripts are elevated in S. cerevisiae cells grown on oleic acid medium, as the gene promoter contains an oleate response element that binds the transcription factors Pip2p and Oaf1pin.; Phenotype: S. cerevisiae ECI1 null mutants are viable, but unable to grow on media containing unsaturated fatty acids such as oleic acid.; Remark: ECI1 of S. cerevisiae is also known as EHD1 or YLR284c.; Remark: the membrane localization is only putative.; Title: strong similarity to delta3-cis-delta2-trans-enoyl-CoA isomerase Eci1 -Saccharomyces cerevisiae; peroxisome; See PMID 9813046; uncharacterized protein 504023 4988622 An16g02290 Aspergillus niger uncharacterized protein XP_001397542.1 503151 R 5061 CDS An16g02300 4988623 join(504340..504411,504468..505256) V 1 NT_166531.1 Title: similarity to hypothetical protein YBR096w -Saccharomyces cerevisiae; uncharacterized protein 505256 4988623 An16g02300 Aspergillus niger uncharacterized protein XP_001397543.1 504340 D 5061 CDS An16g02310 84593339 505470..505730 V 1 NT_166531.1 Similarity: the predicted ORF shows some local similarity to different fragments of reverse transcriptases, likely resulting from retrotransposition events.; Title: weak similarity to reverse transcriptase pol - Tricholoma sejunctum; uncharacterized protein 505730 84593339 An16g02310 Aspergillus niger uncharacterized protein XP_059606761.1 505470 D 5061 CDS An16g02320 4988625 join(506977..507121,507299..507661,507716..507975,508036..508986) V 1 NT_166531.1 Title: weak similarity to protein fragment SEQ ID NO:38570 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 508986 4988625 An16g02320 Aspergillus niger uncharacterized protein XP_059606762.1 506977 D 5061 CDS An16g02330 4988626 complement(join(510115..511589,511656..511791)) V 1 NT_166531.1 Function: FLU1 of C. albicans confers resistance to fluconazole and cycloheximide to a S. cerevisiae strain hypersensitive to multiple drugs.; Function: multidrug transporters are membrane proteins which, by an unknown mechanism, recognize diverse toxic compounds and efflux them from cells.; Similarity: the predicted ORF shows strong similarity to known and hypothetical members of the multidrug efflux transporters belonging to the major facilitator superfamily of transport proteins.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 8987357; See PMID 11065353; uncharacterized protein 511791 4988626 An16g02330 Aspergillus niger uncharacterized protein XP_001397546.1 510115 R 5061 CDS An16g02340 84593340 join(512342..512533,512925..513041,513503..513604) V 1 NT_166531.1 Title: questionable ORF; uncharacterized protein 513604 84593340 An16g02340 Aspergillus niger uncharacterized protein XP_059606763.1 512342 D 5061 CDS An16g02350 4988628 complement(513739..515082) V 1 NT_166531.1 Catalytic activity: trichothecene 3-O-acetyltransferase of Fusarium catalyzes O-acetylation of the trichothecene ring specifically at the C-3 position in an acetyl-CoA-dependent manner.; Function: TRI101 of F. sporotrichioides converts isotrichodermol to isotrichodermin and is required for the biosynthesis of T-2 toxin.; Function: trichothecene 3-O-acetyltransferase protects Fusarium from the produced toxin.; Remark: trichothecene sesquiterpenoid mycotoxins are potent protein synthesis inhibitors for eukaryotic organisms, and are produced by different fungal genera,including Fusarium.; Title: strong similarity to trichothecene 3-O-acetyltransferase TRI101 - Fusarium sporotrichioides; See PMID 9430709; See PMID 9762900; uncharacterized protein 515082 4988628 An16g02350 Aspergillus niger uncharacterized protein XP_001397548.1 513739 R 5061 CDS An16g02360 4988629 complement(join(515706..516640,516701..516755)) V 1 NT_166531.1 Catalytic activity: PLR of S. pombe catalyzes the reaction pyridoxine + NADP+ = pyridoxal + NADPH.; Pathway: PLR of S. pombe is involved in the vitamin B6 metabolism.; Title: strong similarity to pyridoxine 4-dehydrogenase PLR - Schizosaccharomyces pombe; See PMID 10438489; uncharacterized protein 516755 4988629 An16g02360 Aspergillus niger uncharacterized protein XP_001397549.1 515706 R 5061 CDS An16g02370 4988630 complement(join(517311..517511,517539..518072)) V 1 NT_166531.1 Remark: a very similar sequence from S. spinosa has been patented under patentnumber WO9946387-A1.; Remark: putative sequencing error at position 29690 introducing a stop codon conflicting with several good BLASTP matches.; Similarity: SDR is a very large family of enzymes,most of which are known to be NAD- or NADP-dependent oxidoreductases with different specificities.; Similarity: the predicted ORF shows strong similarity to several hypothetical and described members of the short chain dehydrogenase (SDR) protein family.; Title: strong similarity to sequence 37 from patent WO0116303 - Saccharopolyspora spinosa [putative sequencing error]; putative sequencing error; See PMID 7742302; uncharacterized protein 518072 4988630 An16g02370 Aspergillus niger uncharacterized protein XP_059606764.1 517311 R 5061 CDS An16g02380 10098059 join(519035..519063,519228..519297,519368..519448,519512..520122,520173..520347,520400..520799,520912..521024) V 1 NT_166531.1 Similarity: the N-terminal part of the predicted ORF contains some motifs commonly found in oxidoreductases.; Title: strong similarity to hypothetical trunk lateral cell specific gene HrTLC1 - Halocynthia roretzi; uncharacterized protein 521024 10098059 An16g02380 Aspergillus niger uncharacterized protein XP_059606765.1 519035 D 5061 CDS An16g02390 4988632 join(521734..521783,521837..522415,522475..522613,522665..523054) V 1 NT_166531.1 Title: similarity to hypothetical protein encoded by An08g08410 - Aspergillus niger; uncharacterized protein 523054 4988632 An16g02390 Aspergillus niger uncharacterized protein XP_059606766.1 521734 D 5061 CDS An16g02400 4988633 complement(join(523077..523638,523703..523977)) V 1 NT_166531.1 Remark: the predicted ORF shows strong similarity to ORF 2 in the cited reference.; Title: strong similarity to hypothetical protein of the lovastatin biosynthesis gene cluster - Aspergillus terreus; See PMID 10334994; uncharacterized protein 523977 4988633 An16g02400 Aspergillus niger uncharacterized protein XP_001397553.3 523077 R 5061 CDS An16g02410 84593341 complement(join(525357..525471,525552..525724)) V 1 NT_166531.1 hypothetical protein 525724 84593341 An16g02410 Aspergillus niger hypothetical protein XP_059606767.1 525357 R 5061 CDS An16g02420 4988635 join(526306..526920,526977..527654,527716..528399,528458..528907,528964..529551) V 1 NT_166531.1 Title: weak similarity to hypothetical CG7701 -Drosophila melanogaster; uncharacterized protein 529551 4988635 An16g02420 Aspergillus niger uncharacterized protein XP_001397555.1 526306 D 5061 CDS An16g02430 4988636 join(530435..530555,530639..530799,530848..531570,531627..531833) V 1 NT_166531.1 Function: cofactor C of H. sapiens is a tubulin-folding protein, involved in the final step of the beta tubulin folding pathway.; Title: similarity to tubulin-folding cofactor C -Homo sapiens; See PMID 8706133; uncharacterized protein 531833 4988636 An16g02430 Aspergillus niger uncharacterized protein XP_001397556.1 530435 D 5061 CDS An16g02440 4988637 complement(join(532302..532335,532373..532397,532480..533696,533755..534041)) V 1 NT_166531.1 Title: strong similarity to hypothetical mlr1518 -Mesorhizobium loti; uncharacterized protein 534041 4988637 An16g02440 Aspergillus niger uncharacterized protein XP_059606768.1 532302 R 5061 CDS An16g02450 4988638 complement(join(534464..534543,534592..534809,534865..535741,535789..535994,536183..536216,536410..536956)) V 1 NT_166531.1 Similarity: the N-terminal half of the predicted ORF is constituted by almost 50% of low complexity regions,with weak similarity to several different neurofilament proteins of mammals.; Similarity: the main feture of the predicted ORF is to show similarity to the A. thaliana F17F16. 3 in the C-terminal half.; Title: similarity to hypothetical protein F17F16.3 -Arabidopsis thaliana; uncharacterized protein 536956 4988638 An16g02450 Aspergillus niger uncharacterized protein XP_059606769.1 534464 R 5061 CDS An16g02460 4988639 join(537744..537755,537850..537899,537961..538280,538334..538669,538725..539691,539745..540340,540390..541474,541532..541786) V 1 NT_166531.1 Complex: the coatomer is an oligomeric complex that consist of at least the alpha, beta, beta', gamma, delta,epsilon and zeta subunits.; Function: coatomer complex is required for budding from golgi membranes, and is essential for the retrograde golgi-to-ER transport of dilysine-tagged proteins.; Function: the coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER,via the golgi up to the trans golgi network.; Localization: the coatomer is cytoplasmic or polymerized on the cytoplasmic side of the golgi, as well as on the vesicles/buds originating from it.; Remark: the predicted ORF is almost identical, both at the protein and the DNA level, to the putative A. nidulans coatomer alpha subunit sodVIC.; Similarity: the predicted ORF shows strong similarity to the coatomer alpha subunit, conserved from yeast to mammals.; Title: strong similarity to alpha subunit of the coatomer complex Ret1 - Saccharomyces cerevisiae; See PMID 7724544; See PMID 8001155; See PMID 10361037; uncharacterized protein 541786 4988639 An16g02460 Aspergillus niger uncharacterized protein XP_001397559.3 537744 D 5061 CDS An16g02470 4988640 complement(join(542308..542785,542850..543016)) V 1 NT_166531.1 Complex: Erv1 of S. cerevisiae is a homodimer.; Function: Erv1 is involved in the cell-division cycle and the maintenance of mitochondrial genomes in S. cerevisiae.; Similarity: A. niger EST EMBLEST:BE759295 comprises the last nucleotides of the coding region and a part of the putative 3'-UTR of the predicted gene.; Similarity: the C-terminal part of Erv1 of S. cerevisiae is conserved also in the mammalian homologues and is responsible for the catalytic activity (formation of disulfide bridges).; Similarity: the N-terminal part of Erv1 of S. cerevisiae displays a high degree of variability and significant differences even among closely related species,which may account for differences in subcellular localization.; Similarity: the N-terminal part of the predicted ORF shows only weak similarity to Erv1 of S. cerevisiae.; Title: strong similarity to FAD-linked sulfhydryl oxidase Erv1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8972573; See PMID 10384986; See PMID 1552903; See PMID 10899311; uncharacterized protein 543016 4988640 An16g02470 Aspergillus niger uncharacterized protein XP_001397560.3 542308 R 5061 CDS An16g02480 4988641 join(543659..543916,544011..544841) V 1 NT_166531.1 Title: weak similarity to HIRA-interacting protein 3 HIRIP3 - Homo sapiens; See PMID 9710638; uncharacterized protein 544841 4988641 An16g02480 Aspergillus niger uncharacterized protein XP_001397561.1 543659 D 5061 CDS An16g02490 4988642 join(545696..545772,545828..545848,545919..546050,546110..546747,546803..547371,547426..547787,547850..548297) V 1 NT_166531.1 Function: adaptins mediate the interaction of transmembrane receptors to clathrin in the formation of the clathrin-coated transport vesicles.; Function: beta-adaptin is required for the formation of vesicles both at the plasma membrane coated pits, and at the TGN membranes.; Remark: the similarity of the predicted ORF to adaptins is weaker in the C-terminal, but it is possible that some coding regions are missing from the gene model due to the vicinity of the contig border.; Similarity: the predicted ORF shows strong similarity to the beta-adaptin of Drosophila, but also yeast, plants and mammalian species.; Title: strong similarity to beta-adaptin BAD1 -Drosophila melanogaster; See PMID 8006084; See PMID 1969413; See PMID 7593184; uncharacterized protein 548297 4988642 An16g02490 Aspergillus niger uncharacterized protein XP_001397562.1 545696 D 5061 CDS An16g02500 4988643 join(548838..548973,549037..549340,549423..550989,551502..551525) V 1 NT_166531.1 Catalytic activity: trpB of A. nidulans catalyses the reaction L-serine + L-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H(2)O.; Cofactor: trpB of A. nidulans requires pyridoxal phosphate (by similarity).; Pathway: trpB of A. nidulans catalyses the last (fifth) step in biosynthesis of tryptophan.; Regulation: directly upstream of the transcriptional start site, one well conserved potential binding site for the cross-pathway control transcriptional activator CPCA was found. the level of trpB transcript was shown to be regulated by cross-pathway control. a knockout mutant for trpB displays tryptophan auxotrophy, no trpB transcript is detectable, and development is perturbed to an extent that is dependent on the amount of tryptophan added to the medium.; Similarity: tryptophan synthase (trpB) of A. nidulans is similar to the trpA and trpB family of tryptophan synthases.; Title: strong similarity to tryptophan synthase trpB - Aspergillus nidulans; cytoplasm; See PMID 10905354; uncharacterized protein 551525 4988643 An16g02500 Aspergillus niger uncharacterized protein XP_001397563.3 548838 D 5061 CDS An16g02510 4988644 join(552522..552695,552763..553374,553443..553736) V 1 NT_166531.1 Catalytic activity: alcohol dehydrogenase C (ADHC) of M. smegmatis catalyses the reaction alcohol + NADP+ = aldehyde + NADPH.; Cofactor: ADHC of M. smegmatis needs zinc as a co-factor.; Function: the kinetic parameters of the purified ADHC of M. smegmatis showed that using NADPH as electron donor it has a strong preference for aliphatic and aromatic aldehyde substrates. this enzyme is more likely to act as an aldehyde reductase than as an alcohol dehydrogenase.; Title: strong similarity to alcohol dehydrogenase C ADHC - Mycobacterium smegmatis; cytoplasm; See PMID 11257547; uncharacterized protein 553736 4988644 An16g02510 Aspergillus niger uncharacterized protein XP_001397564.1 552522 D 5061 CDS An16g02520 4988645 join(554082..554135,554237..554562,554632..555498,555541..555856) V 1 NT_166531.1 Catalytic activity: threonine synthase (THR4) of S. cerevisiae catalyses the reaction o-phospho-L-homoserine + H(2)O =L-threonine + orthophosphate.; Cofactor: THR4 of S. cerevisiae needs pyridoxal phosphate as a co-factor.; Pathway: THR4 of S. cerevisiae catalyses the last step in threonine biosynthesis.; Title: strong similarity to threonine synthase Thr4 - Saccharomyces cerevisiae; See PMID 2204248; uncharacterized protein 555856 4988645 An16g02520 Aspergillus niger uncharacterized protein XP_059606770.1 554082 D 5061 CDS An16g02530 4988646 complement(556761..>557150) V 1 NT_166531.1 Remark: N-terminal truncated ORF due to end of contig.; Similarity: similarity of the predicted A. niger protein to various protein sequences is due to low complexity sequences.; hypothetical protein [truncated ORF] 557150 4988646 An16g02530 Aspergillus niger hypothetical protein [truncated ORF] XP_001397566.3 556761 R 5061 CDS An16g02540 10098060 complement(join(<557251..558241,558340..558346,558410..558476)) V 1 NT_166531.1 Catalytic activity: Triacylglycerol + H(2)O <=> diacylglycerol + a fatty acid anion.; Function: In breast-fed infants, digestion of milk triglycerides is catalyzed by a concerted action of gastric lipase, colipase-dependent pancreatic lipase, and bile salt-stimulated lipase (BSSL).; Remark: C terminal truncated orf.; Similarity: the N-terminal half of the H. sapiens homolog BSSL is highly conserved between species and shows striking homology to typical esterases, for example,acetylcholine esterase. In contrast, the C-terminal half is unique to BSSL, but all typical properties of BSSL regarding its activity reside in the N-terminal half.; Title: strong similarity to biologically functional bile salt stimulated lipase BSSL from patent WO9325669-A -Homo sapiens [truncated orf]; uncharacterized protein 558476 10098060 An16g02540 Aspergillus niger uncharacterized protein XP_059604749.1 557251 R 5061 CDS An16g02550 4988648 join(560038..560252,560312..560509,560567..>561696) V 1 NT_166531.1 Function: the S. cerevisisae homolog Pri1p is the DNA primase small subunit (DNA polymerase alpha 48 kDa subunit). This highly conserved DNA polymerase alpha-primase complex is required for both the initiation and elongation steps of DNA replication.; Remark: Eukaryotic DNA primase initiates the synthesis of all new DNA strands by synthesizing short RNA oligomers on single-stranded DNA. Additionally, primase helps couple replication and repair and is critical for telomere maintenance and, therefore, chromosome stability.; Title: strong similarity to DNA primase Pri1 -Saccharomyces cerevisiae [putative frameshift]; putative frameshift; uncharacterized protein 561696 4988648 An16g02550 Aspergillus niger uncharacterized protein XP_059604750.1 560038 D 5061 CDS An16g02560 4988649 join(562087..562218,562288..563282,563345..563738) V 1 NT_166531.1 Remark: classification of Xylella fastidiosa homolog XF1621 by sequence similarity.; Title: strong similarity to hypothetical beta-lactamase XF1621 - Xylella fastidiosa; uncharacterized protein 563738 4988649 An16g02560 Aspergillus niger uncharacterized protein XP_001397569.1 562087 D 5061 CDS An16g02570 4988650 complement(join(563950..563975,564032..564558,564631..564689,564753..564874,565052..565250)) V 1 NT_166531.1 Function: the A. nidulans homolog suAprgA1 was isolated as a regulator of penicillin biosynthesis.; Remark: an Aspergillus nidulans strain deleted in the homolog suAprgA1 gene produced about 60% of the amount of penicillin produced by a wild-type strain.; Title: strong similarity to gene involved in the regulation of penicillin biosynthesis suAprgA1 -Aspergillus nidulans; uncharacterized protein 565250 4988650 An16g02570 Aspergillus niger uncharacterized protein XP_001397570.1 563950 R 5061 CDS An16g02580 4988651 complement(join(565672..565939,566014..566098,566164..566332)) V 1 NT_166531.1 Title: strong similarity to hypothetical protein YOR252w - Saccharomyces cerevisiae; uncharacterized protein 566332 4988651 An16g02580 Aspergillus niger uncharacterized protein XP_059604751.1 565672 R 5061 CDS An16g02590 4988652 join(566780..566792,566851..566998,567055..569170) V 1 NT_166531.1 Catalytic activity: the S. pombe homolog ExoI is a 5'->3' double-stranded DNA exonuclease.; Induction: S. pombe ExoI is induced during meiotic prophase I.; Similarity: the Schizosaccharomyces pombe gene exo1 is a member of a family of related DNA repair genes,including RAD2/rad13/xpgc and YKL510/rad2, conserved from yeast to humans.; Title: strong similarity to exodeoxyribonuclease I exo1p - Schizosaccharomyces pombe; uncharacterized protein 569170 4988652 An16g02590 Aspergillus niger uncharacterized protein XP_001397572.1 566780 D 5061 CDS An16g02595 4988653 join(571029..571056,571122..571190,571243..571832) V 1 NT_166531.1 putative sequencing error; hypothetical protein 571832 4988653 An16g02595 Aspergillus niger hypothetical protein XP_059604752.1 571029 D 5061 CDS An16g02610 4988654 complement(join(572629..572671,572747..572785,572973..573574,573643..574139,574210..574396,574467..574787)) V 1 NT_166531.1 Function: S. cerevisiae Flr1p is a multiple drug resistance (MDR) determinant.; Induction: expression of S. cerevisiae FLR1 is induced by addition of benomyl, dependent on the pleiotropic drug resistance (PDR) network and the transcriptional regulator Pdr3p.; Similarity: the S. cerevisiae homolog Flr1p is a a transporter of the major facilitator superfamily.; Title: strong similarity to fluconazole resistance transporter Flr1 - Saccharomyces cerevisiae; uncharacterized protein 574787 4988654 An16g02610 Aspergillus niger uncharacterized protein XP_059604753.1 572629 R 5061 CDS An16g02620 84593342 complement(join(574882..575031,575384..575473)) V 1 NT_166531.1 hypothetical protein 575473 84593342 An16g02620 Aspergillus niger hypothetical protein XP_059604754.1 574882 R 5061 CDS An16g02630 84593343 complement(join(575515..575580,575674..575736,576001..576057)) V 1 NT_166531.1 hypothetical protein 576057 84593343 An16g02630 Aspergillus niger hypothetical protein XP_059604755.1 575515 R 5061 CDS An16g02640 84593344 join(578456..578608,578671..578874,578938..578988,579048..579668,579976..580702,581324..581832) V 1 NT_166531.1 Title: strong similarity to hypothetical protein MTH632 - Methanobacterium thermoautotrophicum; uncharacterized protein 581832 84593344 An16g02640 Aspergillus niger uncharacterized protein XP_059604756.1 578456 D 5061 CDS An16g02650 4988658 complement(join(582442..583513,583567..583835,583891..584072,584127..584174,584234..584315)) V 1 NT_166531.1 Similarity: the ORF shows strong similarity to expressed sequence tag seq id no:3929 of patent WO200056762-A2 from Aspergillus niger.; Title: strong similarity to hypothetical protein SPBC4.02c - Schizosaccharomyces pombe; uncharacterized protein 584315 4988658 An16g02650 Aspergillus niger uncharacterized protein XP_001397578.3 582442 R 5061 CDS An16g02660 4988659 join(585038..585245,585307..586165,586268..586295) V 1 NT_166531.1 Title: similarity to hypothetical RING finger protein - Schizosaccharomyces pombe; uncharacterized protein 586295 4988659 An16g02660 Aspergillus niger uncharacterized protein XP_001397579.3 585038 D 5061 CDS An16g02670 4988660 complement(join(586411..587942,588008..588149)) V 1 NT_166531.1 Title: weak similarity to hypothetical protein SPAC6B12.11 - Schizosaccharomyces pombe; uncharacterized protein 588149 4988660 An16g02670 Aspergillus niger uncharacterized protein XP_001397580.1 586411 R 5061 CDS An16g02680 4988661 complement(588659..589591) V 1 NT_166531.1 Title: strong similarity to hypothetical protein YBR151w - Saccharomyces cerevisiae; uncharacterized protein 589591 4988661 An16g02680 Aspergillus niger uncharacterized protein XP_059604757.1 588659 R 5061 CDS An16g02690 84593345 join(589866..590027,590147..590275,590599..590676,590775..590879) V 1 NT_166531.1 hypothetical protein 590879 84593345 An16g02690 Aspergillus niger hypothetical protein XP_059604758.1 589866 D 5061 CDS An16g02700 4988663 join(591152..591811,591911..593189,593241..593542,593607..593693,593756..593833) V 1 NT_166531.1 Similarity: the S. cerevisiae homolog YIL130w shows GAL4 zinc binuclear cluster homology.; Title: similarity to hypothetical membrane protein YIL130w - Saccharomyces cerevisiae; uncharacterized protein 593833 4988663 An16g02700 Aspergillus niger uncharacterized protein XP_001397583.1 591152 D 5061 CDS An16g02710 84593346 join(594040..594195,594448..594538,594627..594736) V 1 NT_166531.1 hypothetical protein 594736 84593346 An16g02710 Aspergillus niger hypothetical protein XP_059604759.1 594040 D 5061 CDS An16g02720 84593347 complement(join(594861..595067,595305..595410,595481..595642,595711..595791,595885..595943)) V 1 NT_166531.1 hypothetical protein 595943 84593347 An16g02720 Aspergillus niger hypothetical protein XP_059604760.1 594861 R 5061 CDS An16g02730 4988666 join(596168..596964,597018..597205,597256..597284,597336..597422) V 1 NT_166531.1 Catalytic activity: A. niger ABN-A has arabinan-degrading activity and has the ability to cleave (1-2), (1-3) or (1-5) alpha L-arabinosidic linkages and can cleave the 1-6 linkage between the terminal arabinofuranosyl unit and the intermediate glucosyl unit of monoterpenyl alpha-L-arabinofuranosyl glucosides.; Remark: the A. niger homolog ABN-A is a secreted protein.; Title: strong similarity to endo 1,5-alpha-arabinase abnA from patent EP506190-A - Aspergillus niger; uncharacterized protein 597422 4988666 An16g02730 Aspergillus niger uncharacterized protein XP_001397586.3 596168 D 5061 CDS An16g02740 4988667 join(599049..599165,599255..599350,599492..600087,600169..600364) V 1 NT_166531.1 Title: strong similarity to hypothetical protein encoded by An15g02580 - Aspergillus niger; uncharacterized protein 600364 4988667 An16g02740 Aspergillus niger uncharacterized protein XP_059605595.1 599049 D 5061 CDS An16g02750 84593348 complement(join(601097..601381,601421..601766,601858..602105)) V 1 NT_166531.1 Remark: similarity to Arabidopsis sp. prenyltransferase designated ATPT3 patent WO200063391-A2.; Title: similarity to prenyltransferase designated ATPT3 from patent WO200063391-A2 - Arabidopsis sp.; uncharacterized protein 602105 84593348 An16g02750 Aspergillus niger uncharacterized protein XP_059605596.1 601097 R 5061 CDS An16g02760 4988669 complement(join(603444..604244,604279..604510,604566..605432,605483..605739,605803..605885,605947..606088)) V 1 NT_166531.1 Title: strong similarity to hypothetical protein BH0842 - Bacillus halodurans; uncharacterized protein 606088 4988669 An16g02760 Aspergillus niger uncharacterized protein XP_059605597.1 603444 R 5061 CDS An16g02770 4988670 complement(join(606603..606947,607009..607377,607430..608012,608093..608226)) V 1 NT_166531.1 Remark: strong similarity to Arabidopsis thaliana protein fragment SEQ ID NO: 50033 patent EP1033405-A2.; Similarity: belongs to the dimethylaniline monooxygenase (N-oxide-forming) family.; Title: strong similarity to protein fragment SEQ ID NO:50033 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 608226 4988670 An16g02770 Aspergillus niger uncharacterized protein XP_001397590.1 606603 R 5061 CDS An16g02780 84593349 complement(join(608546..608604,608762..608872,608926..609075,609278..609341)) V 1 NT_166531.1 hypothetical protein 609341 84593349 An16g02780 Aspergillus niger hypothetical protein XP_059605598.1 608546 R 5061 CDS An16g02790 84593350 join(609747..609772,609858..609933,610030..610131,610302..610367,610498..610549,610633..610681,610742..610904) V 1 NT_166531.1 hypothetical protein 610904 84593350 An16g02790 Aspergillus niger hypothetical protein XP_059605599.1 609747 D 5061 CDS An16g02800 84593351 complement(join(611111..611413,611523..611629,611669..611758,611808..611835)) V 1 NT_166531.1 hypothetical protein 611835 84593351 An16g02800 Aspergillus niger hypothetical protein XP_059605600.1 611111 R 5061 CDS An16g02810 84593352 612024..613319 V 1 NT_166531.1 Remark: there are nucleoporins with different length matching to this ORF.; Title: weak similarity to nucleoporin Rat7 -Saccharomyces cerevisiae; See PMID 7744966; uncharacterized protein 613319 84593352 An16g02810 Aspergillus niger uncharacterized protein XP_059605601.1 612024 D 5061 CDS An16g02820 4988675 complement(join(613900..615419,615488..616474,616538..616978,617043..617288,617431..617551)) V 1 NT_166531.1 Remark: Fusarium oxysporum fatty-acid hydroxylase CYP505 is a membrane-bound eukaryotic counterpart of Bacillus megaterium cytochrome P450BM3, a fused protein of cytochrome P450 and its reductase.; Title: strong similarity to fatty acid omega-hydroxylase CYP505 - Fusarium oxysporum; See PMID 8830036; See PMID 10995755; uncharacterized protein 617551 4988675 An16g02820 Aspergillus niger uncharacterized protein XP_001397595.1 613900 R 5061 CDS An16g02830 84593353 join(617809..617937,618075..618212) V 1 NT_166531.1 hypothetical protein 618212 84593353 An16g02830 Aspergillus niger hypothetical protein XP_059605602.1 617809 D 5061 CDS An16g02850 4988678 complement(join(619154..619448,619516..620312)) V 1 NT_166531.1 Remark: alternative name is YGR189c.; Remark: the yeast deletion mutant did not show mating, sporulation or growth defects and overexpression causes high resistance to ketoconazole (35 microM) and intermediate resistance to benomyl (140 microM) and miconazole (2 microM).; Title: strong similarity to cell wall protein Crh1 -Saccharomyces cerevisiae; See PMID 10757808; uncharacterized protein 620312 4988678 An16g02850 Aspergillus niger uncharacterized protein XP_001397597.1 619154 R 5061 CDS An16g02860 84593354 complement(join(621655..621759,621858..622056,622107..622770,623010..623105,623128..623257,623539..623544)) V 1 NT_166531.1 hypothetical protein 623544 84593354 An16g02860 Aspergillus niger hypothetical protein XP_059605603.1 621655 R 5061 CDS An16g02870 84593355 623978..625261 V 1 NT_166531.1 hypothetical protein 625261 84593355 An16g02870 Aspergillus niger hypothetical protein XP_059605604.1 623978 D 5061 CDS An16g02880 4988680 join(625951..625985,626041..626686) V 1 NT_166531.1 Catalytic activity: L-lysine = cadaverine + CO2.; Catalytic activity: also acts on 5-hydroxy-L-lysine.; Similarity: the predicted protein shows much stronger similarity to S. cerevisiae YJL055w, a hypothetical protein with unknown function.; Title: similarity to lysine decarboxylase ECORLD -Eikenella corrodens; See PMID 11312612; uncharacterized protein 626686 4988680 An16g02880 Aspergillus niger uncharacterized protein XP_059605605.1 625951 D 5061 CDS An16g02890 4988682 complement(join(627114..627776,627833..628336)) V 1 NT_166531.1 Catalytic activity: adenosine + H2O = inosine + NH3; Phenotype: adenosine deaminase deficiency in mammals is the cause of one form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins.; Title: strong similarity to adenosine deaminase Aah1 - Saccharomyces cerevisiae; See PMID 6392474; See PMID 9335580; See PMID 1577682; uncharacterized protein 628336 4988682 An16g02890 Aspergillus niger uncharacterized protein XP_001397601.1 627114 R 5061 CDS An16g02900 84593356 complement(join(629305..629391,629609..629926,630087..630089)) V 1 NT_166531.1 Title: weak similarity to hypothetical protein CP0627 - Chlamydophila pneumoniae; uncharacterized protein 630089 84593356 An16g02900 Aspergillus niger uncharacterized protein XP_059605606.1 629305 R 5061 CDS An16g02910 4988684 complement(join(630677..631046,631096..631199,631296..631313,631365..631453,631506..632047,632109..632199,632252..632767,632818..632938,632986..633072,633185..633306,633372..633639)) V 1 NT_166531.1 Function: due to the short stretches of homology to these proteins, the absence of further functional domains in the predicted ORF, and the hypothetical function assignement to many BLASTP homologues, it is not possible to draw conclusions about the function of the protein.; Similarity: the predicted protein shows also some similarity to a little portion of sugar hydrolases, like alpha-mannosidases or xylanases.; Title: strong similarity to hypothetical protein CC0533 - Caulobacter crescentus; uncharacterized protein 633639 4988684 An16g02910 Aspergillus niger uncharacterized protein XP_059605607.1 630677 R 5061 CDS An16g02920 4988685 join(634584..634595,634786..635864,635918..636569) V 1 NT_166531.1 Similarity: the similarity to A. nidulans amyR and other transcription facotrs is due to the presence of an N-terminal fungal binuclear zinc cluster.; Title: weak similarity to transcription regulator of maltose utilization amyR - Aspergillus nidulans; See PMID 11318101; uncharacterized protein 636569 4988685 An16g02920 Aspergillus niger uncharacterized protein XP_059605608.1 634584 D 5061 CDS An16g02930 4988686 complement(join(636750..636922,636970..637475,637550..637773)) V 1 NT_166531.1 Catalytic activity: ERG3 of S. cerevisiae encodes C-5 sterol desaturase, which catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis.; Phenotype: Cells lacking ERG3 are viable, but cannot grow on non-fermentable carbon sources, and some erg3 null strains are cold sensitive;furthermore mutations in ERG3 alter sensitivity to a wide variety of drugs.; Similarity: C-5 sterol desaturases have been identified in numerous organisms; homologs from Candida albicans, Arabidopsis, Nicotiana tabacum, and human can complements the erg3 null phenotype in S. cerevisiae.; Title: strong similarity to C-5 sterol desaturase Erg3 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 7766188; See PMID 8109167; See PMID 8180700; See PMID 331007; See PMID 1864507; uncharacterized protein 637773 4988686 An16g02930 Aspergillus niger uncharacterized protein XP_001397605.1 636750 R 5061 CDS An16g02940 4988687 join(638532..638701,638958..639591) V 1 NT_166531.1 Similarity: the predicted protein shows equally strong similarity to the muscle specific human transcript PTD001, with unknown function.; Title: strong similarity to protein fragment SEQ ID NO:69506 from patent EP1033405-A2 - Zea mays; uncharacterized protein 639591 4988687 An16g02940 Aspergillus niger uncharacterized protein XP_001397606.1 638532 D 5061 CDS An16g02950 4988688 complement(join(640234..641430,641503..641628)) V 1 NT_166531.1 Title: strong similarity to essential protein SEQ ID NO:7146 from patent WO200253728-A2 - Candida albicans; uncharacterized protein 641628 4988688 An16g02950 Aspergillus niger uncharacterized protein XP_001397607.1 640234 R 5061 CDS An16g02960 4988689 join(642171..642330,642389..643583,643647..643887) V 1 NT_166531.1 Catalytic activity: a prenyl-L-cysteine + H2O = a prenol + L-cysteine.; Catalytic activity: the isoprenoid product of prenylcysteine lyase is the C-1 aldehyde of the isoprenoid moiety; the enzyme requires molecular oxygen as a cosubstrate and utilizes a noncovalently bound flavin cofactor in an NAD(P)H-independent manner; a stoichiometric amount of hydrogen peroxide is produced during the reaction; these findings indicate that prenylcysteine lyase utilizes a novel oxidative mechanism to cleave thioether bonds and provide insight into the unique role this enzyme plays in the cellular metabolism of prenylcysteines.; Function: prenylcysteine lyase is a lysosomal enzyme that cleaves prenylcysteines to cysteine during the degradation of prenylated proteins.; Remark: EC number: 4. 4. 1. 18.; Title: strong similarity to prenylcysteine lyase PCL1 - Homo sapiens; lysosome; See PMID 9287348; See PMID 10585463; See PMID 11078725; uncharacterized protein 643887 4988689 An16g02960 Aspergillus niger uncharacterized protein XP_059605609.1 642171 D 5061 CDS An16g02970 4988690 complement(join(644488..645451,645530..645894,645965..646015,646090..646125)) V 1 NT_166531.1 Catalytic activity: 5,10-Methylenetetrahydrofolate + Glycine + H2O <=> Tetrahydrofolate + L-Serine.; Catalytic activity: glycine hydroxymethyltransferase also catalyses the reaction of glycine with acetaldehyde to form L-threonine, and with 4-trimethylammoniobutanal to form 3-hydroxy-N6,N6,N6-trimethyl-L-lysine.; Pathway: the enzyme is involved in many metabolic pathways, comprising the anabolism and catabolism of many amino acids and the regulation of the C1 pool through folates.; Remark: Serine hydroxymethyltransferase is officially called Glycine hydroxymethyltransferase.; Similarity: the strongest similarity is to the N. crassa protein; its function was demonstrated only by indirect evidences.; Title: strong similarity to cytoplasmic serine hydroxymethyltransferase Shm2 - Saccharomyces cerevisiae; cytoplasm; See PMID 8132653; See PMID 8852837; See PMID 9398220; See PMID 9749667; See PMID 10641038; uncharacterized protein 646125 4988690 An16g02970 Aspergillus niger uncharacterized protein XP_001397609.1 644488 R 5061 CDS An16g02980 4988691 complement(647721..648344) V 1 NT_166531.1 Title: weak similarity to transferrin binding protein B tbpB - Moraxella catarrhalis; See PMID 9712766; uncharacterized protein 648344 4988691 An16g02980 Aspergillus niger uncharacterized protein XP_001397610.1 647721 R 5061 CDS An16g02990 4988692 join(648955..648985,649051..649788,649844..650426,650494..650704) V 1 NT_166531.1 Catalytic activity: 2-phospho-D-glycerate = 3-phospho-D-glycerate; 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate.; Pathway: the enzyme is essential for glycolysis and gluconeogenesis.; Similarity: the predicted ORF is almost identical to phosphoglyceromutase of A. oryzae, whose enzymatic activity was not experimentally demonstrated.; Title: strong similarity to phosphoglycerate mutase pgm - Bacillus subtilis; See PMID 8021172; uncharacterized protein 650704 4988692 An16g02990 Aspergillus niger uncharacterized protein XP_001397611.1 648955 D 5061 CDS An16g03000 4988693 complement(join(651268..651321,651387..651447,651529..651724,651883..651943)) V 1 NT_166531.1 Complex: the Gim complex is constituted by GIM1/YKE2, GIM2/PAC10, GIM3, GIM4 and GIM5 and promotes the formation of functional alpha- and gamma-tubulin.; Remark: YKE2 of S. cerevisiae si also called GIM1 or YLR200w.; Title: strong similarity to Gim complex component Yke2 - Saccharomyces cerevisiae; cytoplasm; See PMID 7828874; See PMID 9463374; uncharacterized protein 651943 4988693 An16g03000 Aspergillus niger uncharacterized protein XP_001397612.1 651268 R 5061 CDS An16g03010 4988694 join(652452..652750,652827..653159,653225..653675,653732..653953) V 1 NT_166531.1 Complex: nucleotide-free or ADP-bound form of VPS4 exists as a dimer, whereas in the ATP-locked state, VPS4 dimers assemble into a decameric complex.; Function: VPS4 ATPase catalyzes the release (uncoating) of an endosomal membrane-associated class E protein complex(es) required for normal morphology and sorting activity of the endosome.; Function: VPS4 of S. cerevisiae is involved in vacuolar sorting, in the internalization and delivery steps of endocytosis.; Remark: VPS4 of S. cerevisiae is also known as VPT10, VPL4, END13, COS8, DID6 or YPR173c.; Title: strong similarity to vacuolar protein sorting-associated protein Vps4 - Saccharomyces cerevisiae; See PMID 3062374; See PMID 3536126; See PMID 3538017; See PMID 2676511; See PMID 3049619; uncharacterized protein 653953 4988694 An16g03010 Aspergillus niger uncharacterized protein XP_001397613.1 652452 D 5061 CDS An16g03020 4988695 complement(join(654964..655195,655264..658115,658163..658753)) V 1 NT_166531.1 Function: in particular it must be noted that the predicted protein does not contain any recognized ATP-binding nor actin-binding motives, rather three leucine zipper domains.; Similarity: the A. nidulans protein and the predicted A. niger protein are similar to a S. pombe protein, called PCP1 or SPAC6G9. 06C, claimed to be a spindle body component that binds calmodulin, but still unpublished.; Similarity: the C-terminal part of the predicted protein is almost identical to A. nidulans calmodulin-binding coil-coil protein; this is a protein database entry derived from an uncomplete mRNA sequence,unpublished and with an hypothetical function assignment.; Similarity: the similarity to myosin heavy chain of many molluscs is much weaker, and the function assignment must be considered hypothetical.; Title: similarity to myosin heavy chain - Pecten maximus; See PMID 11129432; uncharacterized protein 658753 4988695 An16g03020 Aspergillus niger uncharacterized protein XP_001397614.1 654964 R 5061 CDS An16g03030 4988696 join(659172..659436,659478..659695,659751..661124) V 1 NT_166531.1 Title: strong similarity to hypothetical suppressor of S. cerevisiae gcr2 - Homo sapiens; uncharacterized protein 661124 4988696 An16g03030 Aspergillus niger uncharacterized protein XP_059605610.1 659172 D 5061 CDS An16g03040 4988697 join(661724..661729,661820..661860,662022..662075,662331..662834,662918..663188,663264..663386) V 1 NT_166531.1 Phenotype: AMMECR1 is a human gene of unknown function included in the deleted region of the contiguous gene deletion syndrome AMME, located in Xq22. 3, that includes Alport syndrome (A), mental retardation (M),midface hypoplasia (M), and elliptocytosis (E).; Similarity: the predicted ORF is identical to A. niger EST EMBLEST:BE760000.; Title: strong similarity to hypothetical AMMECR1 -Homo sapiens; See PMID 10049589; See PMID 10828604; uncharacterized protein 663386 4988697 An16g03040 Aspergillus niger uncharacterized protein XP_059605611.1 661724 D 5061 CDS An16g03050 4988698 complement(join(664241..664832,664901..665231,665305..665395,665489..665668)) V 1 NT_166531.1 Function: Ca2+/calmodulin-dependent protein kinases (CaM-kinases) II, IV, and I play important roles as Ca2+ responsive multifunctional protein kinases in controlling a variety of cellular functions in response to an increase in intracellular Ca2+.; Phenotype: null mutation of cmkB in A. nidulans is lethal; perturbations of gene function cause, among other effects, abnormal sporulation.; Similarity: cmkB of A. nidulans is the homologue of mammalian CaM kinases (CaMKs) I/IV.; Title: strong similarity to calcium/calmodulin dependent protein kinase cmkB - Aspergillus nidulans; See PMID 9601605; See PMID 10366852; See PMID 10609316; See PMID 10988293; See PMID 11173518; uncharacterized protein 665668 4988698 An16g03050 Aspergillus niger uncharacterized protein XP_003188935.1 664241 R 5061 CDS An16g03060 4988699 complement(join(666722..672675,672726..672790,672923..673530)) V 1 NT_166531.1 Function: POL2 of S. cerevisiae is the catalytic subunit A of the DNA polymerase epsilon, essential for DNA replication and involved in DNA nucleotide excision repair,required for arrest in response to inhibition of DNA replication.; Similarity: the predicted protein is very similar to nimP, the DNA polymerase epsilon homolog of Emericella nidulans, still unpublished.; Title: strong similarity to DNA-directed DNA polymerase epsilon Pol2 - Saccharomyces cerevisiae; nucleus; See PMID 7667891; See PMID 10022887; See PMID 10072354; See PMID 10097122; See PMID 1291235; uncharacterized protein 673530 4988699 An16g03060 Aspergillus niger uncharacterized protein XP_059605612.1 666722 R 5061 CDS An16g03070 4988700 join(674009..674342,674407..674663) V 1 NT_166531.1 Remark: the systematic gene name of COX20 is YDR231c.; Title: weak similarity to mitochondrial protein involved in cytochrome oxidase maturation and assembly Cox20 - Saccharomyces cerevisiae; uncharacterized protein 674663 4988700 An16g03070 Aspergillus niger uncharacterized protein XP_001397619.1 674009 D 5061 CDS An16g03080 4988701 complement(join(674961..676103,676260..676277)) V 1 NT_166531.1 hypothetical protein 676277 4988701 An16g03080 Aspergillus niger hypothetical protein XP_001397620.3 674961 R 5061 CDS An16g03090 4988702 complement(join(676485..676760,676848..677967,678027..678190)) V 1 NT_166531.1 Complex: Nop56p of S. cerevisiae physically interacts with Nop1p in the C+D box snoRNP.; Function: Nop56p of S. cerevisiae is also involved in 27SB pre-rRNA processing.; Function: Nop56p of S. cerevisiae is required for 35S pre-rRNA processing at the A0, A1 and A2 cleavage sites.; Localization: Nop56p of S. cerevisiae is localized at the nucleolus.; Pathway: Nop56p of S. cerevisiae is involved in the pathway of 18S, 25S and 5,8S rRNA biosynthesis.; Remark: the systematic gene name of NOP56 of S. cerevisiae is YLR197w, an alternative name is SIK1.; Title: strong similarity to small nucleolar RNP component Nop56 - Saccharomyces cerevisiae; nucleus; See PMID 9372940; See PMID 10733567; uncharacterized protein 678190 4988702 An16g03090 Aspergillus niger uncharacterized protein XP_001397621.1 676485 R 5061 CDS An16g03100 4988703 join(678568..678609,678692..678786,678840..678861,678922..678963,679016..679036,679092..679265,679328..680554) V 1 NT_166531.1 Complex: the TCP-1-containing cytosolic chaperonin of M. musculus is a heterooligomer including at least the CCT alpha, beta, gamma, delta, epsilon, zeta and eta subunits.; Function: the TCP-1-containing cytosolic chaperonin of M. musculus assists the folding of proteins upon ATP hydrolysis.; Remark: CctZ of M. musculus is subject of the protein sequence patent WO9520654-A1 (PATENTPROT:AAR79582).; Title: strong similarity to TCP-1-containing cytosolic chaperonin zeta subunit CctZ - Mus musculus; cytoplasm; See PMID 7953530; uncharacterized protein 680554 4988703 An16g03100 Aspergillus niger uncharacterized protein XP_001397622.1 678568 D 5061 CDS An16g03110 4988704 complement(join(681225..681584,681610..681613,681652..682296,682335..682374,682409..682478,682732..682750,682941..682978,683068..683084,683113..683161,683234..683356)) V 1 NT_166531.1 Catalytic activity: Acetyl-CoA + histone = CoA + acetylhistone; Function: hMOF of H. sapiens has histone acetyltransferase activity directed toward histones H3, H2A and H4.; Function: hMOF of H. sapiens is involved in the regulation of chromatin structure thereby excerting control of gene expression levels.; Function: the Drosophila ortholog MOF of hMOF of H. sapiens is part of the compensasome involved in gene dosage compensation.; Similarity: belongs to the MYST family of histone acetyltransferases.; Title: strong similarity to histone acetyl transferase hMOF - Homo sapiens; See PMID 10786633; See PMID 11230534; uncharacterized protein 683356 4988704 An16g03110 Aspergillus niger uncharacterized protein XP_059605613.1 681225 R 5061 CDS An16g03120 4988705 684507..686585 V 1 NT_166531.1 Function: NSR1 of S. cerevisiae binds the nuclear localization sequence of the histone H2B.; Function: NSR1 of S. cerevisiae is involved in pre-rRNA processing.; Similarity: homology to NSR1 of S. cerevisiae is restricted to the RNA recognition motif.; Title: similarity to nucleolar protein Nsr1 -Saccharomyces cerevisiae; See PMID 7926838; See PMID 1706724; uncharacterized protein 686585 4988705 An16g03120 Aspergillus niger uncharacterized protein XP_059605614.1 684507 D 5061 CDS An16g03130 4988706 join(686986..687251,687324..687444,687501..688479,688582..688745) V 1 NT_166531.1 Catalytic activity: ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn).; Function: YCR024c of S. cerevisiae is a nuclear gene coding for a mitochondrial tRNA-synthetase.; Title: strong similarity to mitochondrial asparagine--tRNA ligase YCR024c - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9030748; uncharacterized protein 688745 4988706 An16g03130 Aspergillus niger uncharacterized protein XP_059605615.1 686986 D 5061 CDS An16g03140 4988707 complement(join(690209..691846,691988..692182)) V 1 NT_166531.1 Similarity: belongs to the family of acyltransferases usually involved in secondary metabolism activities (PF02458).; Title: similarity to hypothetical anthranilate N-hydroxycinnamoyl/benzoyltransferase At2g19070 -Arabidopsis thaliana; uncharacterized protein 692182 4988707 An16g03140 Aspergillus niger uncharacterized protein XP_001397626.3 690209 R 5061 CDS An16g03150 84593357 join(692435..692546,692617..692704,692771..692853,692916..693035,693206..693295,693398..693522,693658..694023) V 1 NT_166531.1 hypothetical protein 694023 84593357 An16g03150 Aspergillus niger hypothetical protein XP_059605616.1 692435 D 5061 CDS An16g03160 84593358 join(696100..696102,696212..696250,696388..696438,696587..696730) V 1 NT_166531.1 Title: questionable ORF; uncharacterized protein 696730 84593358 An16g03160 Aspergillus niger uncharacterized protein XP_059602721.1 696100 D 5061 CDS An16g03170 84593359 complement(join(699151..699301,699401..699470,699536..699599,699676..699842,699943..700056,700262..700320,700589..700630,700746..700912)) V 1 NT_166531.1 hypothetical protein 700912 84593359 An16g03170 Aspergillus niger hypothetical protein XP_059602722.1 699151 R 5061 CDS An16g03180 84593360 complement(join(702085..702214,702334..702432,702514..702566,702654..702800)) V 1 NT_166531.1 hypothetical protein 702800 84593360 An16g03180 Aspergillus niger hypothetical protein XP_059602723.1 702085 R 5061 CDS An16g03190 84593361 join(702890..703632,703731..703761) V 1 NT_166531.1 Function: pac2 overexpression in S. pombe represses the expression of ste11 which controls the onset of sexual development.; Title: strong similarity to cAMP-independent repressor of ste11 expression ac2p - Schizosaccharomyces pombe; See PMID 8536311; uncharacterized protein 703761 84593361 An16g03190 Aspergillus niger uncharacterized protein XP_059602724.1 702890 D 5061 CDS An16g03195 84593362 complement(703927..704262) V 1 NT_166531.1 hypothetical protein 704262 84593362 An16g03195 Aspergillus niger hypothetical protein XP_059602725.1 703927 R 5061 CDS An16g03200 84593363 complement(join(705128..705164,705298..705652,705917..705939,706239..706443,706478..706501,706537..706615,706680..706772)) V 1 NT_166531.1 hypothetical protein 706772 84593363 An16g03200 Aspergillus niger hypothetical protein XP_059602726.1 705128 R 5061 CDS An16g03210 84593364 join(707275..707578,707639..707755,707986..708059) V 1 NT_166531.1 Title: weak similarity to hypothetical transcriptional regulator - Clostridium acetobutylicum; uncharacterized protein 708059 84593364 An16g03210 Aspergillus niger uncharacterized protein XP_059602727.1 707275 D 5061 CDS An16g03220 84593365 join(708636..708794,708874..708996,709042..709092,709169..709300) V 1 NT_166531.1 Remark: CAB11213. 1 is encoded by SPAC17H9. 04c from S. pombe.; Title: weak similarity to hypothetical RNA-binding zinc finger protein CAB11213.1 - Schizosaccharomyces pombe; uncharacterized protein 709300 84593365 An16g03220 Aspergillus niger uncharacterized protein XP_059602728.1 708636 D 5061 CDS An16g03230 84593366 join(710204..710771,711023..711163,711355..711542) V 1 NT_166531.1 hypothetical protein 711542 84593366 An16g03230 Aspergillus niger hypothetical protein XP_059602729.1 710204 D 5061 CDS An16g03240 84593367 join(711963..712008,712041..712071,712253..712365,712397..712491) V 1 NT_166531.1 Title: weak similarity to hypothetical membrane lipoprotein CAC13380.1 - Mycoplasma pulmonis; uncharacterized protein 712491 84593367 An16g03240 Aspergillus niger uncharacterized protein XP_059602730.1 711963 D 5061 CDS An16g03250 84593368 complement(join(713283..713349,713387..713420,713467..713521)) V 1 NT_166531.1 Title: questionable ORF; uncharacterized protein 713521 84593368 An16g03250 Aspergillus niger uncharacterized protein XP_059602731.1 713283 R 5061 CDS An16g03260 84593369 complement(join(714168..714602,714642..714835,714918..715150,715191..715236,715304..715502)) V 1 NT_166531.1 Title: weak similarity to Ras guanine nucleotide exchange factor son-of-sevenless sos1 - Mus musculus; uncharacterized protein 715502 84593369 An16g03260 Aspergillus niger uncharacterized protein XP_059602732.1 714168 R 5061 CDS An16g03270 84593370 join(715533..715692,715740..715882) V 1 NT_166531.1 hypothetical protein 715882 84593370 An16g03270 Aspergillus niger hypothetical protein XP_059602733.1 715533 D 5061 CDS An16g03280 84593371 join(716849..717035,717119..717160,717205..717438,717518..717583,717662..717765,717851..717940,718053..718079) V 1 NT_166531.1 Title: weak similarity to Deltex1 - Mus musculus; uncharacterized protein 718079 84593371 An16g03280 Aspergillus niger uncharacterized protein XP_059602734.1 716849 D 5061 CDS An16g03290 4988723 join(719434..720107,720188..720276,720414..721600) V 1 NT_166531.1 Function: Uga3 from S. cerevisiae is a transcriptional activator for GABA catabolic genes.; Remark: synonyms for Uga3 from S. cerevisiae are YDL170w.; Title: similarity to regulator protein Uga3 -Saccharomyces cerevisiae; See PMID 10713424; See PMID 2109179; uncharacterized protein 721600 4988723 An16g03290 Aspergillus niger uncharacterized protein XP_059602735.1 719434 D 5061 CDS An16g03300 4988724 complement(join(723018..723102,723170..723241,723294..723623,723692..724006,724062..724251,724284..724399,724447..724847,724895..724951)) V 1 NT_166531.1 Regulation: the transcription of Uga4 from S. cerevisiae is induced in the presence of GABA.; Remark: Uga4 from S. cerevisiae is an amino acid permease with high specificity for 4-aminobutyric acid (GABA).; Remark: a synonym for Uga4 from S. cerevisiae is YDL210w.; Title: strong similarity to GABA permease Uga4 -Saccharomyces cerevisiae; See PMID 8455553; See PMID 8828907; See PMID 9678893; uncharacterized protein 724951 4988724 An16g03300 Aspergillus niger uncharacterized protein XP_059602736.1 723018 R 5061 CDS An16g03310 4988725 complement(join(725913..727759,727810..727896,727978..728071)) V 1 NT_166531.1 Function: the tol protein from Neurospora crassa mediates growth inhibition and cell death induced by fusion of hyphae of opposite mating type during vegetative growth.; Remark: the coiled-coil domain and the leucine-rich repeat of the tol protein from Neurospora crassa are required for activity.; Title: similarity to mediator for mating-type associated vegetative incompatibility tol - Neurospora crassa; See PMID 8200515; See PMID 9927450; uncharacterized protein 728071 4988725 An16g03310 Aspergillus niger uncharacterized protein XP_001397644.3 725913 R 5061 CDS An16g03320 4988726 join(728965..730290,730337..730434,730484..730824,730873..731310,731360..731551,731620..732254) V 1 NT_166531.1 Complex: human Sec24a co-immunoprecipitate with human Sec23aa.; Complex: human Sec24a co-localizes with the human proteins Sec23 and Sec13.; Function: human Sec24a is probably involved in ER to Golgi transport.; Similarity: human Sec24a belongs to the Sec23/Sec24 protein family.; Title: strong similarity to transport protein Sec24A - Homo sapiens; intracellular transport vesicles; See PMID 10075675; uncharacterized protein 732254 4988726 An16g03320 Aspergillus niger uncharacterized protein XP_001397645.1 728965 D 5061 CDS An16g03330 4988727 734469..735011 V 1 NT_166531.1 Remark: the ORF shows also strong similarity to the Aspergillus niger EST seq id no:4367 of patent WO200056762-A2.; Title: weak similarity to endo-1,4-beta-xylanase CAA93120.1 - Ascochyta pisi; uncharacterized protein 735011 4988727 An16g03330 Aspergillus niger uncharacterized protein XP_001397646.1 734469 D 5061 CDS An16g03340 4988728 complement(join(738459..739410,739585..739874,740010..740344,740414..741084,741157..741357,741424..741572)) V 1 NT_166531.1 Complex: X. laevis CPSF forms a specific complex with RNAs that contain both a cytoplasmic polyadenylation element (CPE) and the polyadenylation element AAUAAA.; Function: immunodepletion of the 100-kDa subunit of X. laevis CPSF reduces CPE-specific polyadenylation in vitro.; Localization: CPSF from X. laevis is predominantly localized to the cytoplasm of oocytes.; Title: strong similarity to cleavage and polyadenylation specificity factor 100 kDa subunit CPSF -Xenopus laevis; cytoplasm; See PMID 10409759; uncharacterized protein 741572 4988728 An16g03340 Aspergillus niger uncharacterized protein XP_059602737.1 738459 R 5061 CDS An16g03350 84593372 742061..742597 V 1 NT_166531.1 Similarity: the similarities are based on repetetive structures.; Title: weak similarity to silk fibroin like protein SEPL4 from patent WO8803533-A - synthetic; uncharacterized protein 742597 84593372 An16g03350 Aspergillus niger uncharacterized protein XP_059602738.1 742061 D 5061 CDS An16g03360 84593373 complement(join(743140..743270,743545..744172)) V 1 NT_166531.1 Similarity: the similarities are mainly based on repetetive structures.; Title: weak similarity to cell wall hydroxyproline-rich glycoprotein HRGPnt3 - Nicotiana tabacum; uncharacterized protein 744172 84593373 An16g03360 Aspergillus niger uncharacterized protein XP_059602739.1 743140 R 5061 CDS An16g03370 4988731 complement(join(745924..746082,746145..747952,748003..748048,748104..748188,748246..748284,748395..748521,748575..749046)) V 1 NT_166531.1 Localization: Cwh43 from S. cerevisiae is localized at the plasma membrane, although localization to the internal structure of the cells could not be excluded, and it concentrates to the bud tip of small budded cells and to the neck of dividing cells.; Phenotype: cwh43-2 mutant from S. cerevisiae shows Calcofluor white hypersensitivity, a growth defect and increased release of beta-1,6-glucan and beta-glucosylated proteins into the growth medium at increased temperatures.; Remark: the synonym for Cwh43 from S. cerevisiae is YCR017c.; Title: strong similarity to sensor/transporter protein involved in maintenance of cell wall integrity Cwh43 - Saccharomyces cerevisiae; plasma membrane; See PMID 11427965; uncharacterized protein 749046 4988731 An16g03370 Aspergillus niger uncharacterized protein XP_001397650.3 745924 R 5061 CDS An16g03380 4988732 join(749622..749711,749790..750881) V 1 NT_166531.1 Title: similarity to diagnostic protein #23219 from patent WO200175067-A2 - Homo sapiens; uncharacterized protein 750881 4988732 An16g03380 Aspergillus niger uncharacterized protein XP_001397651.1 749622 D 5061 CDS An16g03390 4988733 complement(join(751008..751095,751169..751429,751511..751977)) V 1 NT_166531.1 Remark: about the patent EP1033405-A2 is no further information available.; Remark: the matching coding sequence was isolated by carrying out RT-PCR on mRNA obtained from A. thaliana.; Title: similarity to protein fragment SEQ ID NO:29234 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 751977 4988733 An16g03390 Aspergillus niger uncharacterized protein XP_001397652.3 751008 R 5061 CDS An16g03400 4988734 join(<753746..754553,754615..754794,754854..755346,755417..755637,755702..756249) V 1 NT_166531.1 Function: deletion of nab3 in S. cerevisiae results in a decrease in the amount of mature ACT1, CYH2, and TPI1 mRNAs, a concomitant accumulation of unspliced ACT1 pre-mRNA, and an increase in the ratio of unspliced CYH2 pre-mRNA to mRNA.; Function: the Nab3 protein from S. cerevisiae proteins may be required for packaging pre-mRNAs into ribonucleoprotein structures amenable to efficient nuclear RNA processing.; Remark: startcodon is missing.; Remark: synonyms for Nab3 from S. cerevisiae are Hmd1 and YPL190c.; Title: strong similarity to nuclear polyadenylated RNA-binding protein Nab3 - Saccharomyces cerevisiae [truncated ORF]; nucleus; See PMID 7962083; See PMID 10655211; uncharacterized protein 756249 4988734 An16g03400 Aspergillus niger uncharacterized protein XP_001397653.3 753746 D 5061 CDS An16g03410 4988735 complement(join(756811..756933,757076..757300)) V 1 NT_166531.1 Similarity: the ORF also shows similarity to the EST SEQ ID NO:5884 of patent WO200056762-A2 from Aspergillus oryzae.; Title: similarity to hypothetical protein YMR244c-a - Saccharomyces cerevisiae; uncharacterized protein 757300 4988735 An16g03410 Aspergillus niger uncharacterized protein XP_001397654.1 756811 R 5061 CDS An16g03420 4988736 join(757740..757987,758054..758468) V 1 NT_166531.1 Function: overexpression of SYS1 suppresses the ypt6 phenotype of temperature-sensitive growth and partial missorting of the vacuolar enzyme, carboxypeptidase Y.; Phenotype: sys1 deletion mutants of S. cerevisiae show slight growth defects.; Phenotype: ypt6 sys1 mutants show enhanced defects in vacuolar protein sorting and cell growth; Remark: the synonym for Sys1 from S. cerevisiae is YJL004c.; Title: similarity to multicopy suppressor Sys1 -Saccharomyces cerevisiae; See PMID 8923208; uncharacterized protein 758468 4988736 An16g03420 Aspergillus niger uncharacterized protein XP_001397655.1 757740 D 5061 CDS An16g03430 4988737 join(759723..760008,760085..760345,760409..760541,760599..760767,760821..760895) V 1 NT_166531.1 Remark: novR belongs to the novobiocin biosynthetic gene cluster of Streptomyces spheroides.; Remark: novobiocin belongs to the aminocoumarin antibiotics.; Remark: novobiocin inhibits bacterial DNA gyrase by interaction with the N-terminal 24-kDa subdomain.; Similarity: the ORF also shows strong similarity to the EST Dark Grown 1 (DG1) Sorghum bicolor.; Title: strong similarity to novobiocin biosynthetic gene novR - Streptomyces spheroides; See PMID 10770754; uncharacterized protein 760895 4988737 An16g03430 Aspergillus niger uncharacterized protein XP_001397656.1 759723 D 5061 CDS An16g03450 4988739 761977..763404 V 1 NT_166531.1 Similarity: the ORF also shows strong similarity to the EST an_2900 from Aspergillus niger.; Title: similarity to hypothetical protein YNL051w -Saccharomyces cerevisiae; uncharacterized protein 763404 4988739 An16g03450 Aspergillus niger uncharacterized protein XP_001397657.1 761977 D 5061 CDS An16g03460 84593374 join(764363..764467,764526..764566,764703..764721,764819..764890) V 1 NT_166531.1 Title: questionable ORF; uncharacterized protein 764890 84593374 An16g03460 Aspergillus niger uncharacterized protein XP_059602740.1 764363 D 5061 CDS An16g03470 84593375 join(765148..765226,765453..765626,765696..765756,765799..765809,765933..766110,766199..766364,766434..766478,766533..766649) V 1 NT_166531.1 Title: weak similarity to hypothetical protein encoded by 12F11.190 - Neurospora crassa; uncharacterized protein 766649 84593375 An16g03470 Aspergillus niger uncharacterized protein XP_059602741.1 765148 D 5061 CDS An16g03480 84593376 complement(join(767248..767281,767375..767462,767538..767655,767766..767944,768068..768250,768692..768755,768840..768958,769003..769036,769178..769232,769630..769756,769850..769905,769949..769998)) V 1 NT_166531.1 Similarity: the similarities are mainly based on repetetive structures.; Title: weak similarity to neurofilament protein NF-M2 - Xenopus laevis; uncharacterized protein 769998 84593376 An16g03480 Aspergillus niger uncharacterized protein XP_059602742.1 767248 R 5061 CDS An16g03490 4988743 join(770431..772236,772293..772457) V 1 NT_166531.1 Phenotype: overexpression of RGM1 gene greatly impairs cell growth.; Remark: a splice site was detected upstream of the START codon.; Remark: the synonym for Rgm1 from S. cerevisiae is YMR182c.; Title: similarity to transcription repressor Rgm1 -Saccharomyces cerevisiae; nucleus; See PMID 1923755; uncharacterized protein 772457 4988743 An16g03490 Aspergillus niger uncharacterized protein XP_001397661.1 770431 D 5061 CDS An16g03500 4988744 join(773947..774058,774125..774225,774304..774474) V 1 NT_166531.1 Title: weak similarity to slow myosin heavy chain myoHC-A4 - Notothenia coriiceps; uncharacterized protein 774474 4988744 An16g03500 Aspergillus niger uncharacterized protein XP_001397662.1 773947 D 5061 CDS An16g03510 4988745 775533..777011 V 1 NT_166531.1 Title: strong similarity to hypothetical protein CAD70874.1 - Neurospora crassa; uncharacterized protein 777011 4988745 An16g03510 Aspergillus niger uncharacterized protein XP_059602743.1 775533 D 5061 CDS An16g03520 4988746 join(777435..777458,777530..780343) V 1 NT_166531.1 Complex: heterodimer of MSH2 and MSH6.; Function: MSH2 of S. cerevisiae is involved in post-replicative DNA-mismatch repair. Msh2 of S. cerevisiae binds to mismatch-containing DNA.; Similarity: MSH2 of S. cerevisiae belongs to the DNA mismatch repair muts family.; Title: strong similarity to DNA mismatch repair protein Msh2 - Saccharomyces cerevisiae; nucleus; See PMID 9545323; uncharacterized protein 780343 4988746 An16g03520 Aspergillus niger uncharacterized protein XP_001397664.1 777435 D 5061 CDS An16g03530 4988747 join(781276..781443,781473..782607,782663..783124,783177..783262,783311..783611,783781..783824) V 1 NT_166531.1 Function: gpi1 is necessary for the synthesis of n-acetylglucosaminyl-phosphatidylinositol, the very early intermediate in gpi-anchor biosynthesis.; Title: similarity to n-acetylglucosaminyl-phosphatidylinositol biosynthetic protein gpi1p - Schizosaccharomyces pombe; See PMID 9046095; uncharacterized protein 783824 4988747 An16g03530 Aspergillus niger uncharacterized protein XP_059602744.1 781276 D 5061 CDS An16g03540 4988748 784882..787230 V 1 NT_166531.1 Complex: Rrp6 of S. cerevisiae is a component of the exosome multienzyme ribonuclease complex composed of at least 11 proteins: Rrp4, Rrp40, Rrp41/Ski6, Rrp42, Rrp43,Rrp44/Dis3, Rrp45, Rrp46, Mtr3, Csl4 and Rrp6.; Function: Rrp6 of S. cerevisiae is a component of the nuclear exosome 3->5 exoribonuclease complex. Rrp6 is required for the 3'processing of the 7s pre-rna to the mature 5. 8s rrna. Rrp6 has a 3'-5' exonuclease activity.; Remark: UNC733 and YOR001W are alternative names for RRP6.; Title: strong similarity to exosome complex exonuclease Rrp6 - Saccharomyces cerevisiae; nucleus; See PMID 9582370; uncharacterized protein 787230 4988748 An16g03540 Aspergillus niger uncharacterized protein XP_001397666.1 784882 D 5061 CDS An16g03550 4988749 complement(join(787431..787467,787537..787618,787708..787841,787915..788131,788231..788411)) V 1 NT_166531.1 Title: similarity to protein fragment SEQ ID NO:17361 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 788411 4988749 An16g03550 Aspergillus niger uncharacterized protein XP_059602745.1 787431 R 5061 CDS An16g03560 84593377 join(789365..790019,790080..790162,790305..790619) V 1 NT_166531.1 hypothetical protein 790619 84593377 An16g03560 Aspergillus niger hypothetical protein XP_059602746.1 789365 D 5061 CDS An16g03570 84593378 complement(join(794438..794548,794881..794931,795163..795237,795348..795448,795571..795666,795847..796024)) V 1 NT_166531.1 Title: weak similarity to hypothetical protein pr1 -Cytomegalovirus maastricht; uncharacterized protein 796024 84593378 An16g03570 Aspergillus niger uncharacterized protein XP_059602747.1 794438 R 5061 CDS An16g03580 4988752 join(796150..796354,796422..796555,796605..798447,798504..798664) V 1 NT_166531.1 Function: sar1 of S. pombe encodes a product capable of regulating ras1 function.; Similarity: sar1 of S. pombe is a member of the family of amily of RAS GTPase-activating proteins (GAPs).; Title: strong similarity to RAS GTPase-activating protein sar1p - Schizosaccharomyces pombe; See PMID 1883874; See PMID 2038319; uncharacterized protein 798664 4988752 An16g03580 Aspergillus niger uncharacterized protein XP_001397670.1 796150 D 5061 CDS An16g03590 4988753 join(800367..800587,800808..800931,801008..801631) V 1 NT_166531.1 Function: sec14 of S. cerevisiae is required for transport of secretory proteins from the golgi complex. Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes in vitro. Essential for viability and secretion.; Remark: SEC14 is an essential gene for yeast vegetative growth and is required for export of yeast secretory proteins from the Golgi complex.; Similarity: sec14 of S. cerevisiae belongs to the sec14 cytosolic factor family.; Title: strong similarity to phosphatidylinositol-phosphatidylcholine transfer protein Sec14 - Saccharomyces cerevisiae; cytoplasm; See PMID 9461221; See PMID 2215682; See PMID 2466847; uncharacterized protein 801631 4988753 An16g03590 Aspergillus niger uncharacterized protein XP_001397671.1 800367 D 5061 CDS An16g03600 4988754 complement(join(802214..802900,802989..803165)) V 1 NT_166531.1 Title: similarity to hypothetical protein SPAC688.02c - Schizosaccharomyces pombe; uncharacterized protein 803165 4988754 An16g03600 Aspergillus niger uncharacterized protein XP_001397672.1 802214 R 5061 CDS An16g03610 4988755 join(803847..805010,805105..805494) V 1 NT_166531.1 Title: similarity to hypothetical protein SPAC1296.04 - Schizosaccharomyces pombe; uncharacterized protein 805494 4988755 An16g03610 Aspergillus niger uncharacterized protein XP_001397673.1 803847 D 5061 CDS An16g03620 4988756 805872..808343 V 1 NT_166531.1 Title: similarity to hypothetical protein CAD37049.1 - Neurospora crassa; uncharacterized protein 808343 4988756 An16g03620 Aspergillus niger uncharacterized protein XP_001397674.1 805872 D 5061 CDS An16g03630 4988757 complement(join(808703..808978,809063..809476)) V 1 NT_166531.1 Function: MAK3 encodes an N-acetyltransferase whose modification of the L-A major coat protein NH2 terminus is essential for viral assembly, unassembled coat protein is unstable.; Title: strong similarity to N-acetyltransferase Mak3 - Saccharomyces cerevisiae; See PMID 1339437; See PMID 1400344; uncharacterized protein 809476 4988757 An16g03630 Aspergillus niger uncharacterized protein XP_001397675.1 808703 R 5061 CDS An16g03640 4988758 join(809759..810073,810146..811553,811619..811706,811747..811785,812132..812168) V 1 NT_166531.1 Catalytic activity: Phosphatidylcholin + a sterol <=> a sterol ester + 1-acylglycerophosphocholine.; Function: mouse LCAT catalyzes the esterification of cholesterol in high density lipoproteins.; Title: similarity to phosphatidylcholine-sterol O-acyltransferase Lcat - Mus musculus; See PMID 2600083; uncharacterized protein 812168 4988758 An16g03640 Aspergillus niger uncharacterized protein XP_059602748.1 809759 D 5061 CDS An16g03650 4988759 complement(join(813488..814385,814462..814883)) V 1 NT_166531.1 Function: aurA gene product is necessary for inositol phosphorylceramide (IPC) synthase activity.; Phenotype: mutations in aurA gene of A. nidulans confer a high level of resistance to aureobasidin A.; Title: strong similarity to aureobasidin-resistance protein aurA - Aspergillus nidulans; See PMID 10102364; uncharacterized protein 814883 4988759 An16g03650 Aspergillus niger uncharacterized protein XP_001397677.1 813488 R 5061 CDS An16g03660 84593379 join(814967..815046,815138..815257,815330..815375,815471..815512,815602..815808) V 1 NT_166531.1 Remark: the ORF shows similarity to cDNA of the aureobasidin-resistance protein aur1 of A. fumigatus. This cDNA belongs to the adjacent gene.; Title: questionable ORF; uncharacterized protein 815808 84593379 An16g03660 Aspergillus niger uncharacterized protein XP_059602749.1 814967 D 5061 CDS An16g03670 84593380 complement(join(816210..816309,816367..816528,816611..816846,816926..816976)) V 1 NT_166531.1 hypothetical protein 816976 84593380 An16g03670 Aspergillus niger hypothetical protein XP_059602750.1 816210 R 5061 CDS An16g03680 84593381 complement(818368..818823) V 1 NT_166531.1 hypothetical protein 818823 84593381 An16g03680 Aspergillus niger hypothetical protein XP_059602751.1 818368 R 5061 CDS An16g03690 4988763 complement(join(820881..821409,821476..821840)) V 1 NT_166531.1 Function: involved in both homeostasis of calcium and manganese ions.; Localization: Ccc1p polypeptide was found to localize to a Golgi-like organelle in yeast.; Title: strong similarity to iron and manganese transporter Ccc1 - Saccharomyces cerevisiae; See PMID 7941738; uncharacterized protein 821840 4988763 An16g03690 Aspergillus niger uncharacterized protein XP_001397681.1 820881 R 5061 CDS An16g03700 4988764 join(823327..823425,823475..823888,823936..824112,824165..824203,824251..824459,824508..824657,824704..825019) V 1 NT_166531.1 Catalytic activity: Phospholipase B catalyzes the reaction of 2-Lysophosphatidylcholine + H2O = Glycerophosphocholine + a fatty acid anion.; Function: Phospholipase B is useful for hydrolysing the fatty acyl group(s) of phospholipids or lysophospholipids, such as lecithin or lysolecithin.; Remark: the ORF encoded protein also shows strong similarity to hypothetical phospholipases C (EC 3. 1. 4. 3) of A. thaliana.; Title: strong similarity to phospholipase B from patent US6146869-A - Aspergillus oryzae; uncharacterized protein 825019 4988764 An16g03700 Aspergillus niger uncharacterized protein XP_001397682.1 823327 D 5061 CDS An16g03710 4988765 complement(join(825308..825518,825598..825803)) V 1 NT_166531.1 Title: weak similarity to hypothetical protein CAD60720.1 - Podospora anserina; uncharacterized protein 825803 4988765 An16g03710 Aspergillus niger uncharacterized protein XP_001397683.1 825308 R 5061 CDS An16g03720 4988766 complement(join(827125..828912,829259..829394,829611..829633)) V 1 NT_166531.1 Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 9383611; See PMID 9987114; See PMID 11152942; See PMID 8710886; uncharacterized protein 829633 4988766 An16g03720 Aspergillus niger uncharacterized protein XP_059604761.1 827125 R 5061 CDS An16g03730 84593382 join(829674..829944,830067..830175,830286..830389,830490..830539,830610..830900) V 1 NT_166531.1 hypothetical protein 830900 84593382 An16g03730 Aspergillus niger hypothetical protein XP_059604762.1 829674 D 5061 CDS An16g03740 4988768 833202..834437 V 1 NT_166531.1 Function: pkaR from A. niger is involved in morphogenesis.; Gene-ID: pkaR; Remark: a splice site was detected upstream of the START codon.; deleted EC_number 2.7.1.37; cAMP-dependent protein kinase regulatory subunit pkaR-Aspergillus niger 834437 pkaR 4988768 pkaR Aspergillus niger cAMP-dependent protein kinase regulatory subunit pkaR-Aspergillus niger XP_001397686.1 833202 D 5061 CDS An16g03750 4988769 complement(join(834764..834775,835061..835293,835438..835936)) V 1 NT_166531.1 Remark: the coding sequence of the protein from patent EP1033405-A2 was isolated by carrying out RT-PCR on all of the mRNA obtained from the plant, and creating a cDNA library which could then be sequenced, allowing the putative protein sequence(s) to be obtained.; Title: similarity to protein fragment SEQ ID NO:72807 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 835936 4988769 An16g03750 Aspergillus niger uncharacterized protein XP_001397687.3 834764 R 5061 CDS An16g03760 4988770 836478..839804 V 1 NT_166531.1 Title: similarity to hypothetical protein 15E6.220 -Neurospora crassa; uncharacterized protein 839804 4988770 An16g03760 Aspergillus niger uncharacterized protein XP_001397688.1 836478 D 5061 CDS An16g03770 84593383 complement(join(<842076..842246,842295..842528,842612..842885,843176..843273,843358..843494,843775..844035,844119..>844172)) V 1 NT_166531.1 putative frameshift; hypothetical protein 844172 84593383 An16g03770 Aspergillus niger hypothetical protein XP_059604763.1 842076 R 5061 CDS An16g03790 4988772 846878..848296 V 1 NT_166531.1 Remark: the ORF encoded protein also shows similarity to a hypothetical cyclin-like protein of S. cerevisiae.; Title: similarity to hypothetical protein SPBC1D7.03c - Schizosaccharomyces pombe; uncharacterized protein 848296 4988772 An16g03790 Aspergillus niger uncharacterized protein XP_059604764.1 846878 D 5061 CDS An16g03800 4988773 complement(join(850287..852128,852189..852203)) V 1 NT_166531.1 Function: the protein from patent WO200008187-A2 is involved in environmental stress tolerance.; Title: similarity to environmental stress tolerance related protein from patent WO200008187-A2 - Arabidopsis thaliana; uncharacterized protein 852203 4988773 An16g03800 Aspergillus niger uncharacterized protein XP_059604765.1 850287 R 5061 CDS An16g03810 4988774 853028..854533 V 1 NT_166531.1 Title: similarity to hypothetical protein B7F18.100 - Neurospora crassa; uncharacterized protein 854533 4988774 An16g03810 Aspergillus niger uncharacterized protein XP_001397692.1 853028 D 5061 CDS An16g03820 4988775 855120..856448 V 1 NT_166531.1 Title: similarity to hypothetical protein B2J23.130 - Neurospora crassa; uncharacterized protein 856448 4988775 An16g03820 Aspergillus niger uncharacterized protein XP_001397693.1 855120 D 5061 CDS An16g03830 4988776 join(857387..857428,857468..859048) V 1 NT_166531.1 Function: pch1p of S. pombe interacts with the cdc2 protein kinase.; Function: pch1p of S. pombe is essential for progression through the whole cell cycle.; Similarity: pch1p of S. pombe belongs to the cyclin family, cyclin C subfamily.; Similarity: the predicted ORF is 188 amino acids shorter at its C-terminus than pch1 of S. pombe.; Title: similarity to cyclin C homolog 1 pch1p -Schizosaccharomyces pombe; See PMID 9115279; uncharacterized protein 859048 4988776 An16g03830 Aspergillus niger uncharacterized protein XP_059604766.1 857387 D 5061 CDS An16g03840 4988777 join(859894..861965,862198..862234) V 1 NT_166531.1 Function: ctf1-alpha of F. solani is a transactivator that binds to the palindrome 2 sequence of the cutinase gene promoter.; Remark: the ORF encoded protein shows weak similarity to several transcription factors and contains BLOCKS and PROSITE Zinc-finger motifs.; Title: weak similarity to cutinase transcription factor 1 CTF1-alpha - Fusarium solani; nucleus; See PMID 9139694; uncharacterized protein 862234 4988777 An16g03840 Aspergillus niger uncharacterized protein XP_001397695.3 859894 D 5061 CDS An16g03850 4988778 complement(join(862548..862569,862607..862612,862718..862744,862793..862806,862882..863626,863677..865322,865370..865682,865738..865967)) V 1 NT_166531.1 Title: similarity to hypothetical protein SPAC57A7.05 - Schizosaccharomyces pombe; uncharacterized protein 865967 4988778 An16g03850 Aspergillus niger uncharacterized protein XP_001397696.3 862548 R 5061 CDS An16g03860 4988779 complement(867105..868853) V 1 NT_166531.1 Catalytic activity: ATP + a protein <=> ADP + a phosphoprotein.; Function: as the its human ortholog, the p70 ribosomal protein S6 kinase p70S6k from Artemia franciscana may be involved in the regulation of protein synthesis during preemergence development.; Title: strong similarity to p70 ribosomal protein S6 kinase p70S6k - Artemia franciscana; deleted EC_number 2.7.1.37; See PMID 11310561; uncharacterized protein 868853 4988779 An16g03860 Aspergillus niger uncharacterized protein XP_001397697.1 867105 R 5061 CDS An16g03870 84593384 join(869310..869596,869685..869784) V 1 NT_166531.1 Similarity: the similarities of the ORF encoded protein to all matching proteins are only based on repetitive structures.; Title: weak similarity to transcription termination factor Rho - Micrococcus luteus; uncharacterized protein 869784 84593384 An16g03870 Aspergillus niger uncharacterized protein XP_059604767.1 869310 D 5061 CDS An16g03880 4988781 complement(join(870106..870294,870368..871231)) V 1 NT_166531.1 Catalytic activity: 2-amino-4-hydroxy-6-(D-erythro-1, 2,3-trihydroxypropyl)-7,8-dihydropteridine <=> 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde.; Function: the multifunctional folic acid synthesis protein Fas from Pneumocystis carinii Folate biosynthesis.; Title: similarity to multifunctional folic acid synthesis protein Fas - Pneumocystis carinii; See PMID 8397083; uncharacterized protein 871231 4988781 An16g03880 Aspergillus niger uncharacterized protein XP_059604768.1 870106 R 5061 CDS An16g03890 4988782 complement(join(871922..872129,872171..872553,872615..872711,872774..872847,873306..873466,873599..873727,874108..874159)) V 1 NT_166531.1 Function: human SRp75 can complement a splicing-deficient extract.; Similarity: the human SRp75 protein belongs to the SR family of splicing factors.; Title: similarity to pre-mRNA splicing factor SRp75 - Homo sapiens; nucleus; See PMID 1577277; See PMID 8321209; uncharacterized protein 874159 4988782 An16g03890 Aspergillus niger uncharacterized protein XP_059604769.1 871922 R 5061 CDS An16g03900 84593385 complement(join(875578..875612,875724..875878,876259..876521)) V 1 NT_166531.1 hypothetical protein 876521 84593385 An16g03900 Aspergillus niger hypothetical protein XP_059604770.1 875578 R 5061 CDS An16g03910 4988784 join(878417..878714,878806..880327,880378..880477) V 1 NT_166531.1 Catalytic activity: reduced ETF + ubiquinone <=> ETF + ubiquinol (ETF=Electron-transferring-flavoprotein).; Cofactor: Iron-sulfur, FAD.; Function: the human electron-transfer flavoprotein-ubiquinone oxidoreductase ETF-QO in the inner mitochondrial membrane accepts electrons from electron-transfer flavoprotein which is located in the mitochondrial matrix and reduces ubiquinone in the mitochondrial membrane.; Title: strong similarity to electron-transfer flavoprotein-ubiquinone oxidoreductase ETF-QO - Homo sapiens; localisation:mitochondrion; See PMID 10423253; See PMID 8306995; uncharacterized protein 880477 4988784 An16g03910 Aspergillus niger uncharacterized protein XP_001397702.1 878417 D 5061 CDS An16g03920 84593386 join(881261..881459,881667..882058) V 1 NT_166531.1 Title: weak similarity to negative regulator LIN-1 -Caenorhabditis elegans; uncharacterized protein 882058 84593386 An16g03920 Aspergillus niger uncharacterized protein XP_059604771.1 881261 D 5061 CDS An16g03930 84593387 join(883147..883313,883637..883805) V 1 NT_166531.1 Title: weak similarity to hypothetical uridylate kinase from chromosome III BAC T22K18 - Arabidopsis thaliana; uncharacterized protein 883805 84593387 An16g03930 Aspergillus niger uncharacterized protein XP_059604772.1 883147 D 5061 CDS An16g03940 4988787 join(885063..885331,885406..885493,885572..886063) V 1 NT_166531.1 Complex: together with the TAF proteins TBP belongs to the TFIID complex, which specifically binds to the TATA box element of PolII relevant promotors and which lies close to the position of transcription initiation.; Function: TBP is the general factor that plays a major role in the activation of eukaryotic genes transcribed by RNA Polymerase II.; Remark: TBP is also called SPT15, BTF1 or YER148.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to subunit of transcription initiation factor TFIID TATA-box binding protein TBP -Aspergillus nidulans; nucleus; See PMID 9141689; See PMID 10974559; uncharacterized protein 886063 4988787 An16g03940 Aspergillus niger uncharacterized protein XP_059604773.1 885063 D 5061 CDS An16g03950 4988788 complement(join(888125..888183,888285..888565,888633..889617,889691..889739)) V 1 NT_166531.1 Cofactor: FAD.; Function: amadoriases are a novel class of FAD enzymes which catalyze the oxidative deglycation of glycated amino acids to yield corresponding amino acids,glucosone, and H(2)O(2).; Remark: alternate name for amadoriase II A. fumigatus: fructosyl amine:oxygen oxidoreductase.; Title: strong similarity to amadoriase II -Aspergillus fumigatus; See PMID 9139700; See PMID 10684633; uncharacterized protein 889739 4988788 An16g03950 Aspergillus niger uncharacterized protein XP_001397706.3 888125 R 5061 CDS An16g03960 4988789 join(890021..890127,890294..891110) V 1 NT_166531.1 Title: similarity to hypothetical proteins YDR316w -Saccharomyces cerevisiae; uncharacterized protein 891110 4988789 An16g03960 Aspergillus niger uncharacterized protein XP_059604774.1 890021 D 5061 CDS An16g03970 84593388 join(891844..891892,892097..892169,892232..892303,892396..892547,892793..892841,893153..893399,893777..893965,894007..894028,894125..894357) V 1 NT_166531.1 hypothetical protein 894357 84593388 An16g03970 Aspergillus niger hypothetical protein XP_059604775.1 891844 D 5061 CDS An16g03980 4988791 join(<895109..895153,895275..895924,896000..897131) V 1 NT_166531.1 Remark: N-terminally truncated ORF due to the end of contig.; Title: strong similarity to hypothetical protein CAF06114.1 - Neurospora crassa [truncated ORF]; uncharacterized protein 897131 4988791 An16g03980 Aspergillus niger uncharacterized protein XP_059602752.1 895109 D 5061 CDS An16g03990 84593389 join(897839..897928,898008..898085) V 1 NT_166531.1 Title: questionable ORF; uncharacterized protein 898085 84593389 An16g03990 Aspergillus niger uncharacterized protein XP_059602753.1 897839 D 5061 CDS An16g04000 10097999 join(898685..899079,899144..899255,899333..900042,900103..901542,902068..905380,905540..905602) V 1 NT_166531.1 Function: deletion and fusion constructs and in vitro mutagenesis indicated that the Zn(II)2Cys6 cluster and the C-terminal end of A. nidulans FacB are required for function.; Function: deletion of the gene confirmed that it is required for growth on acetate as a sole carbon source.; Similarity: FacB of A. nidulans encodes a N-terminal GAL4-like Zn(II)2Cys6 transcriptional activator.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; See PMID 9197408; uncharacterized protein 905602 10097999 An16g04000 Aspergillus niger uncharacterized protein XP_003188954.2 898685 D 5061 CDS An16g04010 4988794 complement(join(906080..908284,908337..908381)) V 1 NT_166531.1 Complex: Tid3 from S. cerevisiae forms a centromere complex together with Nuf2, Spc25 and Spc24.; Remark: synonyms for yeast Tid3 are Ndc80, Hec1,Yil144w.; Title: strong similarity to protein involved in modulating chromosomal segregation Tid3 - Saccharomyces cerevisiae; See PMID 11266451; See PMID 11553715; See PMID 9585415; uncharacterized protein 908381 4988794 An16g04010 Aspergillus niger uncharacterized protein XP_059602754.1 906080 R 5061 CDS An16g04020 4988795 join(908940..908969,909044..909050,909110..909362,909419..909503,909562..910299) V 1 NT_166531.1 Function: Pex14 from Hansenula polymorpha is a peroxisomal membrane protein essential for peroxisome biogenesis.; Localization: Pex14 from Hansenula polymorpha is a component of the peroxisomal membrane.; Remark: Hansenula polymorpha = Pichia angusta.; Title: strong similarity to peroxisomal membrane protein Pex14 - Hansenula polymorpha; peroxisome; See PMID 11330059; See PMID 9009266; uncharacterized protein 910299 4988795 An16g04020 Aspergillus niger uncharacterized protein XP_001397713.1 908940 D 5061 CDS An16g04030 4988796 join(910732..911153,911223..911506,911598..912027,912379..912735,912776..913199) V 1 NT_166531.1 Title: similarity to hypothetical protein B15B10.090 - Neurospora crassa; uncharacterized protein 913199 4988796 An16g04030 Aspergillus niger uncharacterized protein XP_001397714.3 910732 D 5061 CDS An16g04040 4988797 complement(join(915723..916524,916567..916616,916870..916950)) V 1 NT_166531.1 Remark: the patent protein AAY81534 can be useful as a vaccine, for diagnosis of pneumococcal diseases and for screening agents capable of antagonizing or inhibiting expression of the protein.; Similarity: the ORF DNA sequence shows strong similarity to the EST an_2908 from Aspergillus niger.; Similarity: weak similarity to patent protein AAY81534 from Streptococcus pneumoniae.; Title: weak similarity to membrane protein yeeO -Escherichia coli; uncharacterized protein 916950 4988797 An16g04040 Aspergillus niger uncharacterized protein XP_059602755.1 915723 R 5061 CDS An16g04050 4988798 complement(917852..918511) V 1 NT_166531.1 Remark: a clone selected by a screen with rabbit anti-serum against N40 contains a bicistronic operon (AAQ83837) encoding OspE (AAR69628) and OspF (AAR69629) surface lipoproteins.; Remark: a splice site was detected upstream of the START codon.; Title: weak similarity to surface lipoprotein from patent WO9504145-A1 - Borrelia burgdorferi; uncharacterized protein 918511 4988798 An16g04050 Aspergillus niger uncharacterized protein XP_001397716.1 917852 R 5061 CDS An16g04060 4988799 join(919305..919328,919397..919446,919569..919736,919782..920019,920190..920504,920560..920892) V 1 NT_166531.1 Remark: the protein BAB55393. 1 is encoded by the cDNA FLJ14917 fis, clone PLACE1007112 - Homo sapiens.; Title: similarity to hypothetical protein BAB55393.1 - Homo sapiens; uncharacterized protein 920892 4988799 An16g04060 Aspergillus niger uncharacterized protein XP_059602756.1 919305 D 5061 CDS An16g04070 84593390 922943..923311 V 1 NT_166531.1 Title: weak similarity to hypothetical protein BAB08329.1 - Arabidopsis thaliana; uncharacterized protein 923311 84593390 An16g04070 Aspergillus niger uncharacterized protein XP_059602757.1 922943 D 5061 CDS An16g04080 4988801 complement(join(923535..924853,924884..924948,925026..925085,925137..926050,926155..926166)) V 1 NT_166531.1 Function: the tubulin-tyrosine ligase from Sus scrofa catalyzes the ATP-dependent posttranslational addition of tyrosine to the carboxyterminal end of alpha-tubulin.; Title: similarity to tubulin-tyrosine ligase - Sus scrofa; See PMID 11004583; See PMID 8093886; uncharacterized protein 926166 4988801 An16g04080 Aspergillus niger uncharacterized protein XP_059602758.1 923535 R 5061 CDS An16g04090 4988802 complement(join(926405..926900,926966..927421,927522..927700)) V 1 NT_166531.1 Remark: Suggested activities include nutritional sources or supplements, immune stimulating or suppressing activity, haematopoiesis regulating activity, tissue growth activity, activin/inhibin activity,chemotactic/chemokinetic activity, haemostatic and thrombolytic activity, receptor/ligand activity,anti-inflammatory activity, cadherin/tumour invasion suppressor activity and tumour inhibition activity.; Remark: the protein is predicted to have biological activities although no supporting data is given.; Title: strong similarity to secreted protein from patent WO9855614-A2 - Homo sapiens; uncharacterized protein 927700 4988802 An16g04090 Aspergillus niger uncharacterized protein XP_001397720.3 926405 R 5061 CDS An16g04100 4988803 complement(join(928520..928585,928649..934945,935024..935746)) V 1 NT_166531.1 Complex: Cdc39 (Not1) forms a complex together with Not2, Not3, Not4 and Not5.; Function: Cdc39 is a global negative regulator of transcription.; Remark: synonyms for the S. cerevisiae Cdc39 protein are Not1, Ros1, Smd6 and YCR093w .; Title: strong similarity to transcription regulator protein Cdc39 - Saccharomyces cerevisiae; nucleus; See PMID 10661863; See PMID 8428577; See PMID 9463387; uncharacterized protein 935746 4988803 An16g04100 Aspergillus niger uncharacterized protein XP_059602759.1 928520 R 5061 CDS An16g04110 4988804 join(937342..937384,937447..937551,937611..937897,937950..938162,938224..938322,938370..940449,940504..940673) V 1 NT_166531.1 Function: the S. pombe cdc15 gene is involved in septum formation. it is a key element in the reorganization of F-actin at mitosis.; Phenotype: mutations in the S. pombe early septation mutant cdc15 lead to the formation of elongated,multinucleated cells, as a result of S phase and mitosis continuing in the absence of cytokinesis.; Title: strong similarity to cdc15p -Schizosaccharomyces pombe; See PMID 7634333; uncharacterized protein 940673 4988804 An16g04110 Aspergillus niger uncharacterized protein XP_059602760.1 937342 D 5061 CDS An16g04120 4988805 complement(join(943308..943391,943448..943618,943735..944031,944108..944404)) V 1 NT_166531.1 Title: similarity to hypothetical protein SPBC32F12.08c - Schizosaccharomyces pombe; uncharacterized protein 944404 4988805 An16g04120 Aspergillus niger uncharacterized protein XP_059604776.1 943308 R 5061 CDS An16g04130 4988806 join(945249..945994,946052..946649) V 1 NT_166531.1 Title: similarity to hypothetical protein B8I24.160 - Neurospora crassa; uncharacterized protein 946649 4988806 An16g04130 Aspergillus niger uncharacterized protein XP_001397724.1 945249 D 5061 CDS An16g04140 4988807 complement(join(948009..950416,950496..950505)) V 1 NT_166531.1 Phenotype: cdc23 mutants show reduced rates of DNA synthesis and become elongated after cell-cycle arrest.; Remark: the Schizosaccharomyces pombe Cdc23 is required for correct DNA replication.; Title: similarity to replication protein cdc23p -Schizosaccharomyces pombe; See PMID 9745018; See PMID 1934126; uncharacterized protein 950505 4988807 An16g04140 Aspergillus niger uncharacterized protein XP_001397725.1 948009 R 5061 CDS An16g04150 4988808 951109..952350 V 1 NT_166531.1 Title: strong similarity to hypothetical protein B8I24.140 - Neurospora crassa; uncharacterized protein 952350 4988808 An16g04150 Aspergillus niger uncharacterized protein XP_059604777.1 951109 D 5061 CDS An16g04160 4988809 complement(join(952797..952833,952893..953774,953836..954491)) V 1 NT_166531.1 Catalytic activity: ATP + D-galactose <=> ADP + D-galactose 1-phosphate.; Function: the GAL1 gene product converts D-galactose to D-galactose-1-phosphate.; Induction: S. cerevisiae Gal1 is able to relieve the Gal80p-dependent repression of the transcriptional activator of Gal4p.; Induction: the S. cerevisiae GAL1 transcription is controlled by the Gal4p-Gal80p complex. GAL1 induction is galactose dependent.; Title: strong similarity to galactokinase Gal1 -Saccharomyces cerevisiae; cytoplasm; See PMID 6374427; See PMID 9670023; See PMID 1922058; uncharacterized protein 954491 4988809 An16g04160 Aspergillus niger uncharacterized protein XP_001397727.1 952797 R 5061 CDS An16g04170 4988810 join(956745..956908,956988..957086,957158..957225,957297..958982,959047..959102) V 1 NT_166531.1 Catalytic activity: 2-acetolactate + CO(2) = 2 pyruvate.; Cofactor: Thiamine pyrophosphate.; Function: acetolactate synthases catalyses the first step in the valine and isoleucine biosynthesis pathway.; Remark: mutant acetolactate synthase genes can be used for transforming plants to generate resistance to sulphonylurea, triazolopyrimidine sulphonamide and imidazolinone herbicides (see also patent US5605011-A).; Title: strong similarity to acetolactate synthase protein from patent EP257993-A - Saccharomyces cerevisiae; See PMID 2684671; See PMID 3881312; uncharacterized protein 959102 4988810 An16g04170 Aspergillus niger uncharacterized protein XP_001397728.1 956745 D 5061 CDS An16g04180 4988811 960181..961626 V 1 NT_166531.1 Title: similarity to hypothetical protein AAF45871.1 - Drosophila melanogaster; uncharacterized protein 961626 4988811 An16g04180 Aspergillus niger uncharacterized protein XP_001397729.1 960181 D 5061 CDS An16g04190 84593391 complement(join(961976..962315,962391..962707)) V 1 NT_166531.1 Similarity: the similaritiy of the protein to the matching protein is mainly based on repetitive structures.; Title: weak similarity to retinitis pigmentosa GTPase regulator protein AAG00552.1 - Mus musculus; uncharacterized protein 962707 84593391 An16g04190 Aspergillus niger uncharacterized protein XP_059604778.1 961976 R 5061 CDS An16g04200 4988813 complement(join(963467..963754,963806..963997,964138..964216,964423..964457)) V 1 NT_166531.1 Function: Rho2 GTPase regulates the synthesis of alpha-D-glucan; Function: the Schizosaccharomyces pombe GTPase rho2 is involved in the control of cell morphogenesis, cell integrity, and polarization of the actin cytoskeleton.; Similarity: the protein shows also strong similarities to other Rho-like Proteins like Candida CaRho1 protein (patents WO9946286-A2, WO9738293-A2,WO9738129-A1).; Title: strong similarity to GTP-binding protein rho2p - Schizosaccharomyces pombe; plasma membrane; See PMID 9405296; See PMID 11102532; uncharacterized protein 964457 4988813 An16g04200 Aspergillus niger uncharacterized protein XP_059604779.1 963467 R 5061 CDS An16g04210 4988814 complement(966339..967595) V 1 NT_166531.1 Catalytic activity: Salicylate + NADH + O(2) <=> catechol + NAD(+) + H(2)O + CO(2).; Remark: the salicylate hydroxylase NahW from Pseudomonas stutzeri is involved in mineralization of naphthalene.; Similarity: the protein shows also strong similaritiy to the 6-hydroxynicotinic acid mono-oxygenase from Pseudomonas fluorescens (patent JP09121864-A).; Title: strong similarity to salicylate hydroxylase nahW - Pseudomonas stutzeri; See PMID 10197990; uncharacterized protein 967595 4988814 An16g04210 Aspergillus niger uncharacterized protein XP_001397732.1 966339 R 5061 CDS An16g04220 4988815 complement(join(969137..969263,969333..969928)) V 1 NT_166531.1 Catalytic activity: (S)-2-haloacid + H(2)O <=> (R)-2-hydroxyacid + halide; Remark: 2-haloacid halidohydrolases are acting on acids of short-chain lengths, C(2) to C(4), with inversion of configuration at C-2.; Remark: the ORF DNA sequence shows strong similarity to the EST BE760142 from Aspergillus niger.; Title: similarity to 2-haloacid halidohydrolase IVa - Pseudomonas cepacia; See PMID 7684900; See PMID 1376111; uncharacterized protein 969928 4988815 An16g04220 Aspergillus niger uncharacterized protein XP_001397733.1 969137 R 5061 CDS An16g04230 4988816 join(970395..970570,970624..970655,970711..970750,970808..970946,971001..971819,971875..972153,972206..972367) V 1 NT_166531.1 Function: Gap1 is the transporter for L-amino acids,4-aminobutyric acid, ornithine, citrulline and some D-amino acids.; Function: the S. cerevisiae homolog GAP1 encodes the low affinitiy, high capacity general aminoacid permease which is responsible for uptake of aminoacids as source of nitrogen when grown on media with limited N supply.; Induction: S. cerevisiae GAP1 expression is induced by growth on poor nitrogen sources.; Localization: Gap1p is sorted differently on different nitrogen sorces. Gap1p is found predominantly internally by growth on rich nitrogen sources. when grown on poor nitrogen sources Gap1p is sorted from the golgi to the plasma membran.; Title: strong similarity to general amino acid permease Gap1 - Saccharomyces cerevisiae; plasma membrane; See PMID 9199164; See PMID 10654085; See PMID 2194797; uncharacterized protein 972367 4988816 An16g04230 Aspergillus niger uncharacterized protein XP_001397734.1 970395 D 5061 CDS An16g04240 84593392 complement(join(973983..974134,974194..974293)) V 1 NT_166531.1 Title: questionable ORF; uncharacterized protein 974293 84593392 An16g04240 Aspergillus niger uncharacterized protein XP_059604780.1 973983 R 5061 CDS An16g04250 4988818 join(975008..975328,975380..975796,975846..976853) V 1 NT_166531.1 Remark: other matches show similarities to CoA ligase-like proteins.; Remark: the matched sequence of patent EP1033405-A2 is a putative protein fragment from Arabidopsis thaliana.; Title: similarity to hypothetical protein from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 976853 4988818 An16g04250 Aspergillus niger uncharacterized protein XP_001397736.1 975008 D 5061 CDS An16g04260 4988819 join(979255..982276,982331..982444,982501..982970) V 1 NT_166531.1 Remark: an alternate name for SPAC29E6. 10c is SPAC30. 14c; Title: strong similarity to hypothetical coiled-coil protein SPAC29E6.10c - Schizosaccharomyces pombe; uncharacterized protein 982970 4988819 An16g04260 Aspergillus niger uncharacterized protein XP_059604781.1 979255 D 5061 CDS An16g04270 4988820 complement(join(984244..984561,984617..985165,985225..986183,986237..986874,986954..987090)) V 1 NT_166531.1 Function: the protein Vps35 is involved in vacuolar sorting.; Localization: Vps35 is localized at the vacuole, at the endosome and the golgi.; Phenotype: vps35 deletion mutant exhibits defects in sorting of vacuolar carboxypeptidase Y, proteinase A,proteinase B and alkaline phosphatase.; Remark: synonyms for the S. cerevisiae protein Vps35 are Grd9, Vpt7 and YJL154c.; Title: strong similarity to vacuolar protein sorting-associated protein Vps35 - Saccharomyces cerevisiae; vacuole; See PMID 9700157; See PMID 1498362; uncharacterized protein 987090 4988820 An16g04270 Aspergillus niger uncharacterized protein XP_001397738.1 984244 R 5061 CDS An16g04280 84593393 complement(987897..988943) V 1 NT_166531.1 Remark: Sgs-3 from Drosophila is one of the secreted salivary gland glue polypeptides.; Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: weak similarity to precursor of salivary glue protein sgs-3 - Drosophila yakuba; See PMID 3138416; uncharacterized protein 988943 84593393 An16g04280 Aspergillus niger uncharacterized protein XP_059604782.1 987897 R 5061 CDS An16g04290 84593394 complement(join(989358..989481,989722..989778,989884..989916,989997..990074,990174..990280)) V 1 NT_166531.1 Title: questionable ORF; uncharacterized protein 990280 84593394 An16g04290 Aspergillus niger uncharacterized protein XP_059604783.1 989358 R 5061 CDS An16g04300 84593395 join(991188..991294,991334..991493) V 1 NT_166531.1 Title: questionable ORF; uncharacterized protein 991493 84593395 An16g04300 Aspergillus niger uncharacterized protein XP_059604784.1 991188 D 5061 CDS An16g04310 4988824 complement(992122..994440) V 1 NT_166531.1 Complex: Tfc6 from S. cerevisiae is the 91 kDa tau91 subunit of transcription factor IIIC (TFIIIC).; Function: Tfc6 from S. cerevisiae is involved in initiation of rRNA and tRNA transcription by RNA-Polymerase III.; Remark: alternate names for S. cerevisiae Tfc6: Tau91, YDR362c.; Title: similarity to RNA polymerase III transcription initiation factor TFIIIC subunit Tfc6 -Saccharomyces cerevisiae; nucleus; See PMID 9418847; uncharacterized protein 994440 4988824 An16g04310 Aspergillus niger uncharacterized protein XP_059604785.1 992122 R 5061 CDS An16g04320 4988825 join(995135..995164,995221..996174) V 1 NT_166531.1 Remark: the sequence of the patent EP1033405-A2 from Arabidopsis thaliana was obtained by carrying out RT-PCR on all mRNAs.; Similarity: the ORF encoded protein shows also strong similarity to the hypothetical protein SPAPB24D3. 06c from S. pombe.; Title: strong similarity to protein fragment from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 996174 4988825 An16g04320 Aspergillus niger uncharacterized protein XP_001397743.1 995135 D 5061 CDS An16g04330 4988826 complement(join(996336..996969,997042..997145)) V 1 NT_166531.1 Catalytic activity: GDP-mannose + dolichyl phosphate <=> GDP + dolichyl D-mannosyl phosphate.; Function: dolichol phosphate mannose (DPM) synthase activity is required in N-glycosylation, O-mannosylation and glycosylphosphatidylinositol membrane anchoring of protein.; Remark: Trichoderma reesei = Hypocrea jecorina.; Title: strong similarity to mannose phospho-dolichol synthase dpm1 - Hypocrea jecorina; endoplasmatic reticulum; See PMID 11030744; uncharacterized protein 997145 4988826 An16g04330 Aspergillus niger uncharacterized protein XP_001397744.1 996336 R 5061 CDS An16g04340 4988827 complement(join(997525..997799,997834..998032)) V 1 NT_166531.1 Similarity: the similarities of the protein to all matching proteins are mainly based on repetitive structures.; Title: weak similarity to protein AF-9 - Homo sapiens; uncharacterized protein 998032 4988827 An16g04340 Aspergillus niger uncharacterized protein XP_059604786.1 997525 R 5061 CDS An16g04350 4988828 complement(998926..1001058) V 1 NT_166531.1 hypothetical protein 1001058 4988828 An16g04350 Aspergillus niger hypothetical protein XP_001397746.1 998926 R 5061 CDS An16g04360 84593396 complement(join(1001857..1001928,1002113..1002343,1002549..1002636,1002785..1002961,1003108..1003172)) V 1 NT_166531.1 Title: questionable ORF; uncharacterized protein 1003172 84593396 An16g04360 Aspergillus niger uncharacterized protein XP_059604787.1 1001857 R 5061 CDS An16g04370 4988830 complement(join(1003458..1004204,1004238..1004711)) V 1 NT_166531.1 Title: weak similarity to F-box protein FBP-13 from patent WO200012679-A1 - Homo sapiens; uncharacterized protein 1004711 4988830 An16g04370 Aspergillus niger uncharacterized protein XP_059604788.1 1003458 R 5061 CDS An16g04380 84593397 join(1005206..1005263,1005456..1005606,1005696..1005927,1005985..1006229,1006324..1006407,1006476..1006626,1006702..1006806) V 1 NT_166531.1 Title: questionable ORF; uncharacterized protein 1006806 84593397 An16g04380 Aspergillus niger uncharacterized protein XP_059604789.1 1005206 D 5061 CDS An16g04390 4988832 1007871..1010300 V 1 NT_166531.1 Title: similarity to a lung cancer associated polypeptide from patent WO200055180-A2 - Homo sapiens; uncharacterized protein 1010300 4988832 An16g04390 Aspergillus niger uncharacterized protein XP_001397750.1 1007871 D 5061 CDS An16g04400 4988833 join(1010694..1010700,1010870..1010887,1011055..1011119,1011192..1011263,1011334..1011432,1011547..1011654) V 1 NT_166531.1 Complex: S. cerevisiae Ntf2 interacts with the small GTPase Ran/Gsp1p.; Function: S. cerevisiae Ntf2 is required for nuclear protein import.; Localization: S. cerevisiae Ntf2 is concentrated at the nuclear envelope.; Title: strong similarity to nuclear transport factor Ntf2 - Saccharomyces cerevisiae; nucleus; See PMID 8702493; See PMID 9199309; See PMID 10889207; uncharacterized protein 1011654 4988833 An16g04400 Aspergillus niger uncharacterized protein XP_001397751.1 1010694 D 5061 CDS An16g04410 4988834 complement(join(<1011883..1011937,1011971..1012015,1012067..1012734,1012800..1013057,1013118..1013185)) V 1 NT_166531.1 Similarity: the ORF shows strong similarity to EST EMBLEST:BE759512 an_2335 - Aspergillus niger.; Title: strong similarity to hypothetical protein SPAC4C5.03 - Schizosaccharomyces pombe [putative frameshift]; putative frameshift; uncharacterized protein 1013185 4988834 An16g04410 Aspergillus niger uncharacterized protein XP_059604790.1 1011883 R 5061 CDS An16g04420 4988835 join(1014161..1014245,1014315..1014365,1014423..1014570,1014628..1015419,1015472..1015979) V 1 NT_166531.1 Function: it has been suggested that the S. cerevisiae MSC1 is involved in or regulates the DMC1-promoted interhomologue recombination pathway.; Function: mutations in S. cerevisiae msc1 confer a dominant meiotic lethal phenotype in diploid SPO13 meiosis.; Remark: a splice site was detected upstream of the START codon.; Remark: the systematic name for S. cerevisiae MSC1 is YML128c.; Title: strong similarity to meiotic sister-chromatid recombination protein Msc1 - Saccharomyces cerevisiae; See PMID 10511544; uncharacterized protein 1015979 4988835 An16g04420 Aspergillus niger uncharacterized protein XP_001397753.1 1014161 D 5061 CDS An16g04430 4988836 complement(join(1016506..1016736,1016823..1017060,1017149..1017176,1017244..1017256)) V 1 NT_166531.1 Function: bovine MSBP is a high affinity steroid membrane receptor.; Title: strong similarity to membrane steroid hormone-binding protein MSBP - Bos taurus; plasma membrane; See PMID 10359327; See PMID 11446771; uncharacterized protein 1017256 4988836 An16g04430 Aspergillus niger uncharacterized protein XP_001397754.1 1016506 R 5061 CDS An16g04440 4988837 join(1018503..1018669,1018735..1020301) V 1 NT_166531.1 Remark: blastp with the predicted A. niger protein only retrieves random hits to serine and threonine rich proteins.; hypothetical protein 1020301 4988837 An16g04440 Aspergillus niger hypothetical protein XP_001397755.3 1018503 D 5061 CDS An16g04450 4988838 complement(join(1020801..1020895,1020963..1021052,1021122..1021143)) V 1 NT_166531.1 Title: similarity to protein fragment SEQ ID NO:40331 from patent EP1033405-A2 - Zea mays; uncharacterized protein 1021143 4988838 An16g04450 Aspergillus niger uncharacterized protein XP_001397756.1 1020801 R 5061 CDS An16g04460 4988839 join(1021733..1022454,1022503..1022723,1022809..1022919,1022951..1024284) V 1 NT_166531.1 Complex: hPRP4 interacted directly with Clk1 on its C-terminus.; Function: S. pombe PRP4 is involved in in pre-mRNA splicing.; Function: a recombinant yeast/mouse Prp4 phosphorylates the human SR splicing factor ASF/SF2 in vitro in its RS domain.; Function: human PRP4 is a cyclin-dependent kinase (CDK) like kinase related to MAPKs and due to its activation by EGF may play a distinct role in signal transduction in addition to its role in mRNA processing.; Localization: indirect immunofluorescence analysis revealed that endogenous human hPRP4 was distributed in a nuclear speckled pattern.; Regulation: phosphorylation by Clk1 changes the nuclear distribution of hPRP4.; Similarity: S. pombe PRP4 contains WD repeats.; Similarity: similarity is from the C-terminal half of the predicted A. niger protein to S. pombe PRP4, which is 300 aa shorter.; Title: similarity to pre-mRNA splicing modulating serine/threonine kinase prp4p - Schizosaccharomyces pombe; nucleus; See PMID 8371982; See PMID 9102632; See PMID 9328476; See PMID 10799319; See PMID 11418604; uncharacterized protein 1024284 4988839 An16g04460 Aspergillus niger uncharacterized protein XP_059604791.1 1021733 D 5061 CDS An16g04470 84593398 complement(join(1025387..1025448,1025648..1025703,1025783..1025830,1025901..1025953)) V 1 NT_166531.1 Remark: ORF classified questionable due to lenght below 100 aa, an implausible gene structure with short,multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1025953 84593398 An16g04470 Aspergillus niger uncharacterized protein XP_059604792.1 1025387 R 5061 CDS An16g04480 84593399 join(1027816..1027961,1028040..1028151) V 1 NT_166531.1 Remark: the predicted ORF is only 85 amino acids long and contains a relatively long intron.; hypothetical protein 1028151 84593399 An16g04480 Aspergillus niger hypothetical protein XP_059604793.1 1027816 D 5061 CDS An16g04490 84593400 complement(join(1029897..1029942,1030206..1030441)) V 1 NT_166531.1 Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1030441 84593400 An16g04490 Aspergillus niger uncharacterized protein XP_059604794.1 1029897 R 5061 CDS An16g04500 4988843 join(1031217..1031805,1031880..1032517) V 1 NT_166531.1 Complex: S. pombe Ran1 associates with cpc2, Puc1 cyclin and Cdc10 in vivo.; Function: S. pombe Ran1 functions to control the association between the cyclin Puc1 and the Cdc10 transcription complex.; Function: in S. pombe the transition between mitosis and meiosis and the progression through G1 is regulated by Ran1.; Localization: localization of S. pombe Ran1-GFP to the nucleus depends on the scaffolding protein cpc2.; Remark: an alternative name for S. pombe ran1 is pat1.; Title: strong similarity to meiosis control kinase ran1p - Schizosaccharomyces pombe; nucleus; See PMID 3830131; See PMID 9118252; See PMID 9201720; See PMID 10805744; uncharacterized protein 1032517 4988843 An16g04500 Aspergillus niger uncharacterized protein XP_001397761.3 1031217 D 5061 CDS An16g04510 84593401 complement(1033246..1033761) V 1 NT_166531.1 Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_0311 and AN05G11.; Title: strong similarity to EST an_0311 -Aspergillus niger; uncharacterized protein 1033761 84593401 An16g04510 Aspergillus niger uncharacterized protein XP_059604795.1 1033246 R 5061 CDS An16g04520 4988845 complement(join(1034009..1034026,1034110..1034464,1034553..1034704,1034794..1034990,1035090..1035252)) V 1 NT_166531.1 Function: HDE from C. tropicalis encodes the peroxisomal trifunctional beta-oxidation enzyme hydratase-dehydrogenase-epimerase (HDE).; Similarity: the sequence match between the two proteins is located within short-chain alcohol dehydrogenase homology regions.; Title: strong similarity to trifunctional enzyme HDE - Candida tropicalis; See PMID 3267241; See PMID 1937002; See PMID 1937003; uncharacterized protein 1035252 4988845 An16g04520 Aspergillus niger uncharacterized protein XP_001397763.3 1034009 R 5061 CDS An16g04530 4988846 complement(join(1035512..1035838,1035929..1036276,1036323..1036655)) V 1 NT_166531.1 Similarity: similarity is between the N-terminal regions of the predicted A. niger protein and A. nidulans aflR.; Similarity: the N-terminal region of the predicted A. niger protein contains a fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain.; Title: similarity to sterigmatocystin synthesis transcription regulator aflR - Aspergillus nidulans; nucleus; See PMID 8662194; uncharacterized protein 1036655 4988846 An16g04530 Aspergillus niger uncharacterized protein XP_059604796.1 1035512 R 5061 CDS An16g04540 84593402 complement(join(<1037467..1038352,1038443..1038513,1038563..1038628)) V 1 NT_166531.1 Remark: ORF 3'truncated due to end of contig.; Title: strong similarity to hypothetical protein SPBC12C2.09c - Schizosaccharomyces pombe [truncated ORF]; uncharacterized protein 1038628 84593402 An16g04540 Aspergillus niger uncharacterized protein XP_059602761.1 1037467 R 5061 CDS An16g04550 4988848 join(1038705..1038805,1038879..1039743) V 1 NT_166531.1 Title: weak similarity to hypothetical cDNA of GTP-binding protein homolog ypt1 - Neurospora crassa; See PMID 1361212; uncharacterized protein 1039743 4988848 An16g04550 Aspergillus niger uncharacterized protein XP_001397766.1 1038705 D 5061 CDS An16g04560 4988849 complement(join(1040180..1041245,1041296..1041344,1041417..1041459)) V 1 NT_166531.1 Remark: human CGI-87 was identified by homology to a C. elegans gene.; Title: weak similarity to hypothetical protein CGI-87 - Homo sapiens; See PMID 10810093; uncharacterized protein 1041459 4988849 An16g04560 Aspergillus niger uncharacterized protein XP_001397767.3 1040180 R 5061 CDS An16g04570 84593403 complement(join(1041851..1041939,1042018..1042166,1042262..1042387,1042480..1042599,1042679..1042804,1042897..1043097,1043145..1043230,1043311..1043508)) V 1 NT_166531.1 Similarity: the predicted A. niger protein shows weak similarity to rat SP120, a nuclear scaffold protein,and to human nuclear ribonucleoprotein hnRNP U.; Title: strong similarity to EST SEQ ID NO:4286 from patent WO200056762-A2 - Aspergillus niger; uncharacterized protein 1043508 84593403 An16g04570 Aspergillus niger uncharacterized protein XP_059602762.1 1041851 R 5061 CDS An16g04580 4988851 join(1043569..1043877,1044030..1045151) V 1 NT_166531.1 Function: HSPC021 of H. sapiens interacts with Int-6 (a subunit of the eukaryotic translation initiation factor 3 eIF3) and is associated with the eIF3.; Remark: patent WO200004135-A2 shows strong similarity to the predicted A. niger protein and has been described as human short chain alcohol dehydrogenase (SCAD)-related molecule designated ScRM-2.; Title: strong similarity to hypothetical protein HSPC021 - Homo sapiens; See PMID 11042152; See PMID 11590142; uncharacterized protein 1045151 4988851 An16g04580 Aspergillus niger uncharacterized protein XP_001397769.1 1043569 D 5061 CDS An16g04590 84593404 join(1045307..1045426,1045598..1045729) V 1 NT_166531.1 Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_2591 and an_0945.; Title: strong similarity to EST an_2591 -Aspergillus niger; uncharacterized protein 1045729 84593404 An16g04590 Aspergillus niger uncharacterized protein XP_059602763.1 1045307 D 5061 CDS An16g04600 4988853 complement(join(1045929..1046300,1046732..1047184)) V 1 NT_166531.1 Function: S. cerevisiae Isa2p is involved in the assembly of iron-sulfur (Fe/S) clusters in mitochondrial and cytosolic proteins.; Localization: according to one reference S. cerevisiae Isa2p is present within the intermembrane space of the mitochondria while according to the second reference it is localised in the mitochondrial matrix as a soluble protein.; Remark: the systematic name for S. cerevisiae ISA2 is YPR067w.; Title: strong similarity to Fe/S cluster assembly factor Isa2 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 10805735; See PMID 10913600; uncharacterized protein 1047184 4988853 An16g04600 Aspergillus niger uncharacterized protein XP_001397771.3 1045929 R 5061 CDS An16g04630 4988855 join(1047441..1047630,1047695..1048038,1048095..1048578,1048634..1049013,1049207..1049227) V 1 NT_166531.1 Catalytic activity: kynureninases convert L-kynurenine + H(2)O to anthranilate + L-alanine.; Function: human kynureninase is involved in the synthesis of NAD (or NADP) from tryptophan.; Regulation: human kynureninase is a pyridoxal-5'-phosphate-(pyridoxal-P)-dependent enzyme.; Title: strong similarity to kynureninase - Homo sapiens; See PMID 10443567; uncharacterized protein 1049227 4988855 An16g04630 Aspergillus niger uncharacterized protein XP_001397772.3 1047441 D 5061 CDS An16g04640 4988856 complement(join(1049439..1049514,1049600..1049952,1050036..1050167)) V 1 NT_166531.1 Similarity: the ORF shows strong similarity to EST EMBLEST:BE760042 an_2044 - Aspergillus niger.; Title: strong similarity to hypothetical protein SPCC1281.03c - Schizosaccharomyces pombe; uncharacterized protein 1050167 4988856 An16g04640 Aspergillus niger uncharacterized protein XP_001397773.1 1049439 R 5061 CDS An16g04650 4988857 join(1050740..1050778,1051123..1051307,1051375..1051450,1051505..1051869,1051919..1052347,1052398..1053404,1053577..1053605) V 1 NT_166531.1 Function: the H. sapiens homolog BAM22 is member of the beta-adaptin family.; Remark: a splice site was detected upstream of the START codon.; Remark: adaptins are important subunits of heterotetrameric complexes called adaptors, which participate in the clathrin-coated, vesicle-mediated endocytosis and intracellular receptor transport.; Title: strong similarity to beta-adaptin BAM22 -Homo sapiens; intracellular transport vesicles; uncharacterized protein 1053605 4988857 An16g04650 Aspergillus niger uncharacterized protein XP_001397774.3 1050740 D 5061 CDS An16g04660 4988858 complement(join(1053762..1054965,1055044..1055069)) V 1 NT_166531.1 Title: strong similarity to hypothetical protein CAB46758.1 - Schizosaccharomyces pombe; uncharacterized protein 1055069 4988858 An16g04660 Aspergillus niger uncharacterized protein XP_001397775.1 1053762 R 5061 CDS An16g04670 4988859 complement(join(1055554..1057343,1057397..1057492,1057552..1059295)) V 1 NT_166531.1 Similarity: strong similarity to expressed sequence tag an_2565 from Aspergillus niger.; Title: strong similarity to hypothetical protein YJL020c - Saccharomyces cerevisiae; uncharacterized protein 1059295 4988859 An16g04670 Aspergillus niger uncharacterized protein XP_001397776.1 1055554 R 5061 CDS An16g04680 4988860 1060428..1061429 V 1 NT_166531.1 Title: similarity to hypothetical protein SPAC23A1.16c - Schizosaccharomyces pombe; uncharacterized protein 1061429 4988860 An16g04680 Aspergillus niger uncharacterized protein XP_001397777.1 1060428 D 5061 CDS An16g04690 4988861 complement(join(1061833..1061907,1061973..1062170,1062253..1062378,1062451..1062471)) V 1 NT_166531.1 Remark: S17B of S. cerevisiae belongs to the S17E family of ribosomal proteins.; Remark: S17B of S. cerevisiae is also called RP51B and YDR447c.; Similarity: the ORF overlaps with EST no:3823 of patent WO200056762-A2 from Aspergillus niger.; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S17 - Saccharomyces cerevisiae; cytoplasm; See PMID 6092944; 40S ribosomal protein eS17 1062471 4988861 An16g04690 Aspergillus niger 40S ribosomal protein eS17 XP_001397778.1 1061833 R 5061 CDS An16g04700 4988862 complement(1062973..1064340) V 1 NT_166531.1 Complex: the S. cerevisiae homolog Mrp51p cosediments with the mitochondrial ribosomal small subunit.; Function: deletion of S. cerevisiae MRP51 completely blocks mitochondrial gene expression.; Title: similarity to mitochondrial ribosomal protein of the small subunit Mrp51 - Saccharomyces cerevisiae; localisation:mitochondrion; mitochondrial 37S ribosomal protein bS1m 1064340 4988862 An16g04700 Aspergillus niger mitochondrial 37S ribosomal protein bS1m XP_001397779.3 1062973 R 5061 CDS An16g04710 4988863 complement(join(1064593..1065099,1065160..1065450,1065539..1065671,1065727..1065778,1065842..1065863)) V 1 NT_166531.1 Similarity: the S. cerevisiae homolog YGL157W shows sequence similarity to a family of ketoreductase genes,capable of reducing a variety of alpha-ketolactones,alpha-ketolactams and diketones.; Title: strong similarity to hypothetical ketoreductase YGL157W from patent EP918090-A2 -Saccharomyces cerevisiae; uncharacterized protein 1065863 4988863 An16g04710 Aspergillus niger uncharacterized protein XP_001397780.1 1064593 R 5061 CDS An16g04720 4988864 join(1067449..1067575,1067634..1068585,1068640..1072375,1072466..1074343,1074406..1074795) V 1 NT_166531.1 Catalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol <=> ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.; Function: the TOR proteins regulate (i) the initiation and elongation phases of translation, (ii) ribosome biosynthesis, (iii) amino acid import, (iv) the transcription of numerous enzymes involved in multiple metabolic pathways, and (v) autophagy. appears to be a central regulator of cell growth.; Pathway: multiple.; Remark: despite significant homology to lipid kinases, the TOR proteins (as well as the other PIKKs) function as Ser/Thr protein kinases.; Similarity: the S. cerevisiae homolog TOR1 belongs to the superfamily of 1-phosphatidylinositol 3-kinase which were found to be the 'target of rapamycin'.; Title: strong similarity to 1-phosphatidylinositol 3-kinase Tor1 - Saccharomyces cerevisiae; uncharacterized protein 1074795 4988864 An16g04720 Aspergillus niger uncharacterized protein XP_059602764.1 1067449 D 5061 CDS An16g04730 4988865 join(1075381..1075673,1075767..1076199,1076255..1076391,1076447..1077191) V 1 NT_166531.1 Title: similarity to hypothetical protein BAA97377.1 - Arabidopsis thaliana; uncharacterized protein 1077191 4988865 An16g04730 Aspergillus niger uncharacterized protein XP_001397782.1 1075381 D 5061 CDS An16g04750 4988867 join(1078753..1079079,1079146..1079886) V 1 NT_166531.1 Remark: The S. griseus homolog strI belongs to the streptomycin (SM) production genes and bears similarity to a number of dehydrogenases.; Title: strong similarity to hypothetical dehydrogenases strI - Streptomyces griseus; uncharacterized protein 1079886 4988867 An16g04750 Aspergillus niger uncharacterized protein XP_001397783.1 1078753 D 5061 CDS An16g04760 4988868 complement(join(1080860..1080916,1080975..1081865)) V 1 NT_166531.1 Localization: the C. gloeosporioides homolog alr6 is a putative peroxisomal protein.; Title: strong similarity to hypothetical aldehyde reductase 6 alr6 - Colletotrichum gloeosporioides; uncharacterized protein 1081865 4988868 An16g04760 Aspergillus niger uncharacterized protein XP_001397784.1 1080860 R 5061 CDS An16g04770 4988869 join(1083039..1083114,1083171..1083467,1083522..1083902,1083962..1084167) V 1 NT_166531.1 Function: the S. cerevisisae homolog Gcy1p is an enzyme with NADPH-dependent reductase activity.; Title: strong similarity to aldo/keto reductase Gcy1 - Saccharomyces cerevisiae; uncharacterized protein 1084167 4988869 An16g04770 Aspergillus niger uncharacterized protein XP_001397785.1 1083039 D 5061 CDS An16g04780 4988870 complement(join(1084718..1085901,1085960..1087149,1087384..1087399,1087429..1087441,1087589..1087732)) V 1 NT_166531.1 Title: similarity to hypothetical protein NUM1 -Arabidopsis thaliana; uncharacterized protein 1087732 4988870 An16g04780 Aspergillus niger uncharacterized protein XP_059602765.1 1084718 R 5061 CDS An16g04790 4988871 complement(1088673..1092083) V 1 NT_166531.1 Similarity: the ORF shows strong similarity to expressed sequence tag an_3044 from Aspergillus niger.; Title: weak similarity to exo-alpha-sialidase -Trypanosoma cruzi; uncharacterized protein 1092083 4988871 An16g04790 Aspergillus niger uncharacterized protein XP_001397787.1 1088673 R 5061 CDS An16g04800 84593405 complement(join(1093404..1093508,1093807..1093820,1093869..1093883,1093965..1093985,1094096..1094190,1094413..1094538,1094883..1094920)) V 1 NT_166531.1 hypothetical protein 1094920 84593405 An16g04800 Aspergillus niger hypothetical protein XP_059602766.1 1093404 R 5061 CDS An16g04810 84593406 complement(join(1095653..1095738,1095860..1095947,1096052..1096130,1096445..1096518,1096623..1096958)) V 1 NT_166531.1 hypothetical protein 1096958 84593406 An16g04810 Aspergillus niger hypothetical protein XP_059602767.1 1095653 R 5061 CDS An16g04820 4988874 join(1097197..1097446,1097679..1098253) V 1 NT_166531.1 Similarity: the ORF shows strong similarity to expressed sequence tag an_0894 from Aspergillus niger.; Title: strong similarity to hypothetical protein SCD82.04c - Streptomyces coelicolor; uncharacterized protein 1098253 4988874 An16g04820 Aspergillus niger uncharacterized protein XP_001397790.1 1097197 D 5061 CDS An16g04830 4988875 complement(join(1098478..1099445,1099511..1100146,1100261..1100360)) V 1 NT_166531.1 Function: the P. chrysogenum homolog pclA is responsible for activation of the penicillin side chain precursor.; Similarity: shows also strong similarity to several 4-coumarate-CoA ligase-like proteins.; Title: strong similarity to phenylacetyl-CoA ligase pclA from patent WO9702349-A1 - Penicillium chrysogenum; uncharacterized protein 1100360 4988875 An16g04830 Aspergillus niger uncharacterized protein XP_001397791.1 1098478 R 5061 CDS An16g04840 4988876 complement(join(1100968..1101388,1101450..1101567,1101630..1102002,1102059..1102217)) V 1 NT_166531.1 Function: the M. grisea homolog Pth11p is a a pathogenicity factor that functions at the cell cortex as an upstream effector of appressorium differentiation in response to surface cues.; Title: similarity to integral membrane protein PTH11 from patent WO9913094-A2 - Magnaporthe grisea; plasma membrane; uncharacterized protein 1102217 4988876 An16g04840 Aspergillus niger uncharacterized protein XP_001397792.1 1100968 R 5061 CDS An16g04850 84593407 join(1102520..1102749,1102818..1102956) V 1 NT_166531.1 hypothetical protein 1102956 84593407 An16g04850 Aspergillus niger hypothetical protein XP_059602768.1 1102520 D 5061 CDS An16g04860 84593408 complement(join(1103174..1103395,1103586..1103684,1103781..1103810,1103907..1104068,1104176..1104255,1104502..1104547)) V 1 NT_166531.1 hypothetical protein 1104547 84593408 An16g04860 Aspergillus niger hypothetical protein XP_059602769.1 1103174 R 5061 CDS An16g04870 4988879 join(1105919..1106405,1106464..1106576,1106637..1107791) V 1 NT_166531.1 Title: similarity to protein SEQ ID NO:7732 from patent WO200253728-A2 - Candida albicans; uncharacterized protein 1107791 4988879 An16g04870 Aspergillus niger uncharacterized protein XP_001397795.1 1105919 D 5061 CDS An16g04880 4988880 complement(join(1107971..1111185,1111238..1111316,1111365..1111604,1111667..1111777)) V 1 NT_166531.1 Function: PEX1 of P. chrysogenum encodes a protein of the AAA family of ATPases involved in peroxisomal biogenesis.; Title: strong similarity to peroxin-1 PEX1 -Penicillium chrysogenum; peroxisome; See PMID 10968639; uncharacterized protein 1111777 4988880 An16g04880 Aspergillus niger uncharacterized protein XP_001397796.1 1107971 R 5061 CDS An16g04890 4988881 join(1112266..1112580,1112634..1112764,1112813..1114730,1114793..1114852) V 1 NT_166531.1 Complex: the MCM proteins form heteromeric complexes with the proteins in a 1:1 stoichiometry.; Complex: the hexameric complex is apparently composed of a subcomplex consisting of a tightly associated core complex (MCM4/6/7) that is loosely associated with MCM2 and a more loosely associated subcomplex, the peripheral dimer (MCM3/5).; Function: the MCM proteins are essential for the initiation of replication and normal S phase progression.; Function: the minichromosome maintenance (MCM) proteins are a family of essential eukaryotic replication proteins with six distinct members (MCM2-MCM7).; Function: the precise molecular function of the MCM protein complex remains to be determined, a recent report showed weak ATPase and DNA helicase activities in the core complex of human MCM4/6/7, which may be regulated by MCM2.; Title: strong similarity to minichromosome maintenance protein mcm7p - Schizosaccharomyces pombe; nucleus; See PMID 10588642; uncharacterized protein 1114852 4988881 An16g04890 Aspergillus niger uncharacterized protein XP_001397797.1 1112266 D 5061 CDS An16g04900 4988882 complement(join(1115025..1115076,1115303..1115649)) V 1 NT_166531.1 Function: yps-3 of the dimorphic fungus H. capsulatum is expressed in the virulent yeast pahse of this organism, but is silent in the mycelial form of virulent strains.; Title: similarity to yeast phase specific gene yps-3 - Histoplasma capsulatum; See PMID 9673274; See PMID 8012597; uncharacterized protein 1115649 4988882 An16g04900 Aspergillus niger uncharacterized protein XP_001397798.3 1115025 R 5061 CDS An16g04910 4988883 complement(join(1116790..1117674,1117730..1117762,1117822..1117832,1117889..1117935,1117989..1118028,1118091..1118187)) V 1 NT_166531.1 Title: strong similarity to hypothetical conserved protein SPCC61.03 - Schizosaccharomyces pombe; uncharacterized protein 1118187 4988883 An16g04910 Aspergillus niger uncharacterized protein XP_001397799.1 1116790 R 5061 CDS An16g04920 4988884 complement(join(1118844..1119884,1119939..1119944)) V 1 NT_166531.1 Remark: blastp matches are not significant.; Title: weak similarity to ankyrin B - Homo sapiens; uncharacterized protein 1119944 4988884 An16g04920 Aspergillus niger uncharacterized protein XP_059602770.1 1118844 R 5061 CDS An16g04930 4988885 join(1120608..1120766,1120846..1121019) V 1 NT_166531.1 Function: The 60S acidic ribosomal protein plays an important role in the elongation step of protein synthesis.; Remark: a splice site was detected upstream of the START codon.; Similarity: this 60S acidic ribosomal protein family includes archaebacterial L12, eukaryotic P0, P1 and P2.; Title: strong similarity to cytoplasmic acidic ribosomal protein P2 - Aspergillus fumigatus; cytoplasm; See PMID 10636918; See PMID 8722011; ribosomal protein P2 1121019 4988885 An16g04930 Aspergillus niger ribosomal protein P2 XP_001397801.1 1120608 D 5061 CDS An16g04940 4988886 join(1121689..1121706,1121781..1121799,1122080..1122137,1122350..1122646,1122719..1122788) V 1 NT_166531.1 Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S12 AS1 - Podospora anserina; cytoplasm; See PMID 8195128; 40S ribosomal protein uS19 1122788 4988886 An16g04940 Aspergillus niger 40S ribosomal protein uS19 XP_001397802.1 1121689 D 5061 CDS An16g04950 4988887 complement(join(1123151..1123199,1123393..1124147,1124214..1124513,1124659..1124802)) V 1 NT_166531.1 Title: strong similarity to hypothetical protein SPBP8B7.07c - Schizosaccharomyces pombe; uncharacterized protein 1124802 4988887 An16g04950 Aspergillus niger uncharacterized protein XP_059602771.1 1123151 R 5061 CDS An16g04960 84593409 complement(join(1125648..1125755,1125815..>1126732)) V 1 NT_166531.1 Complex: the arginine-specific carbamoylphosphate synthase of S. cerevisiae is composed of two chains: a small (or glutamine) chain, Cpa1p, and a large (or ammonia) chain, Cpa2p.; Function: in S. cervisiae the small chain promotes the hydrolysis of glutamine to ammonia (EC 6. 3. 5. 5),which is used by the large chain to synthesize carbamoyl phosphate (EC 6. 3. 5. 5).; Pathway: arginine biosynthesis.; Remark: N-terminally truncated due to contig border.; Remark: the systematic genename of CPA2 of S. cerevisiae is YJR109C.; Title: strong similarity to arginine-specific carbamoyl-phosphate synthase subunit Cpa2 - Saccharomyces cerevisiae [truncated ORF]; See PMID 2689869; See PMID 8626695; uncharacterized protein 1126732 84593409 An16g04960 Aspergillus niger uncharacterized protein XP_059602772.1 1125648 R 5061 CDS An16g04970 4988889 complement(join(<1126834..1128659,1128834..1129194)) V 1 NT_166531.1 Catalytic activity: 2 ATP + glutamine + CO(2) + H(2)O = 2 ADP + orthophosphate + glutamate + carbamoyl phosphate; Complex: CPA2 of S. cerevisiae forms a heterodimer with CPA1.; Function: CPA2 of S. cerevisiae accepts the ammonia moiety cleaved from glutamine, binds all the remaining substrates and carries out all the subsequent catalytic events.; Remark: CPA2 of S. cerevisiae is also known as YJR109C.; Title: strong similarity to arginine-specific carbamoyl-phosphate synthase subunit Cpa2 - Saccharomyces cerevisiae; See PMID 11212301; See PMID 6358221; See PMID 8626695; uncharacterized protein 1129194 4988889 An16g04970 Aspergillus niger uncharacterized protein XP_001397805.3 1126834 R 5061 CDS An16g04980 84593410 complement(join(1129448..1129687,1129711..1129868,1129963..1130032,1130261..1130368,1130495..1130569)) V 1 NT_166531.1 hypothetical protein 1130569 84593410 An16g04980 Aspergillus niger hypothetical protein XP_059606539.1 1129448 R 5061 CDS An16g04990 84593411 join(1130586..1130642,1130721..1130822,1130932..1131057,1131098..1131142,1131237..1131467) V 1 NT_166531.1 hypothetical protein 1131467 84593411 An16g04990 Aspergillus niger hypothetical protein XP_059606540.1 1130586 D 5061 CDS An16g05000 84593412 join(1131912..1132067,1132148..1132195) V 1 NT_166531.1 hypothetical protein 1132195 84593412 An16g05000 Aspergillus niger hypothetical protein XP_059606541.1 1131912 D 5061 CDS An16g05010 4988893 join(1132662..1132803,1132867..1132940,1132998..1133675) V 1 NT_166531.1 hypothetical protein 1133675 4988893 An16g05010 Aspergillus niger hypothetical protein XP_001397809.3 1132662 D 5061 CDS An16g05020 4988894 join(1134290..1134372,1134435..1134521,1134613..1135216) V 1 NT_166531.1 Title: strong similarity to protein vip1p -Schizosaccharomyces pombe; See PMID 10388810; uncharacterized protein 1135216 4988894 An16g05020 Aspergillus niger uncharacterized protein XP_001397810.1 1134290 D 5061 CDS An16g05030 4988895 complement(join(1135515..1135525,1135657..1135867)) V 1 NT_166531.1 hypothetical protein 1135867 4988895 An16g05030 Aspergillus niger hypothetical protein XP_001397811.3 1135515 R 5061 CDS An16g05040 84593413 join(1136138..1136261,1136368..1136450) V 1 NT_166531.1 hypothetical protein 1136450 84593413 An16g05040 Aspergillus niger hypothetical protein XP_059606542.1 1136138 D 5061 CDS An16g05050 4988897 complement(join(1137790..1137947,1138000..1138117,1138170..1138348,1138400..1140267,1140324..1140508,1140582..1141042,1141165..1141243,1141311..1141400)) V 1 NT_166531.1 Function: The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1.; Title: similarity to importin RanBP7 - Homo sapiens; nucleus; See PMID 9687515; See PMID 10228156; uncharacterized protein 1141400 4988897 An16g05050 Aspergillus niger uncharacterized protein XP_001397813.1 1137790 R 5061 CDS An16g05060 4988898 complement(join(1142052..1142552,1142603..1142782,1142838..1143025,1143078..1143357,1143408..1144345,1144436..1145907,1145963..1146192)) V 1 NT_166531.1 Title: strong similarity to viral mRNA translation inhibitor Ski2 - Saccharomyces cerevisiae; uncharacterized protein 1146192 4988898 An16g05060 Aspergillus niger uncharacterized protein XP_059606543.1 1142052 R 5061 CDS An16g05070 4988899 complement(join(1147373..1149050,1149103..1149585,1149641..1149709,1149781..1149800)) V 1 NT_166531.1 Title: similarity to hypothetical protein SPCC4G3.03 - Schizosaccharomyces pombe; uncharacterized protein 1149800 4988899 An16g05070 Aspergillus niger uncharacterized protein XP_059606544.1 1147373 R 5061 CDS An16g05080 84593414 complement(join(1149852..1150277,1151305..1151419,1151500..1151606)) V 1 NT_166531.1 hypothetical protein 1151606 84593414 An16g05080 Aspergillus niger hypothetical protein XP_059606545.1 1149852 R 5061 CDS An16g05090 4988901 join(1151720..1151746,1151815..1151941,1152003..1152068,1152195..1153975) V 1 NT_166531.1 Title: strong similarity to endonuclease SceI 75 kDa subunit Ens1 - Saccharomyces cerevisiae; See PMID 2203771; uncharacterized protein 1153975 4988901 An16g05090 Aspergillus niger uncharacterized protein XP_001397817.1 1151720 D 5061 CDS An16g05100 84593415 join(1155982..1155984,1156256..1156376,1156836..1156954) V 1 NT_166531.1 hypothetical protein 1156954 84593415 An16g05100 Aspergillus niger hypothetical protein XP_059606546.1 1155982 D 5061 CDS An16g05110 84593416 complement(join(1159127..1159218,1159374..1159542)) V 1 NT_166531.1 hypothetical protein 1159542 84593416 An16g05110 Aspergillus niger hypothetical protein XP_059606547.1 1159127 R 5061 CDS An16g05120 4988904 join(1159788..1160171,1160248..1161222) V 1 NT_166531.1 Title: strong similarity to lovF gene expression regulator At239 from patent WO200257456-A2 - Unclassified organism; uncharacterized protein 1161222 4988904 An16g05120 Aspergillus niger uncharacterized protein XP_001397820.1 1159788 D 5061 CDS An16g05130 4988905 complement(join(1161857..1162665,1162768..1162929,1163042..1163102)) V 1 NT_166531.1 Title: similarity to hypothetical protein SPCC4G3.16 - Schizosaccharomyces pombe; uncharacterized protein 1163102 4988905 An16g05130 Aspergillus niger uncharacterized protein XP_001397821.1 1161857 R 5061 CDS An16g05140 84593417 complement(join(1163147..1163458,1163914..1164066,1164279..1164473,1164631..1164708)) V 1 NT_166531.1 hypothetical protein 1164708 84593417 An16g05140 Aspergillus niger hypothetical protein XP_059606548.1 1163147 R 5061 CDS An16g05150 4988907 join(1164844..1165298,1165369..1165394,1165459..1165854,1165914..1167058,1167114..1167203) V 1 NT_166531.1 Alternative name: Acyl-activating enzyme. Acyl-CoA synthetase. Fatty acid thiokinase (long-chain). Lignoceroyl-CoA synthase.; Catalytic activity: ATP + a long-chain carboxylic acid + CoA <=> AMP + diphosphate + an acyl-CoA; Remark: Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity. The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24).; Title: strong similarity to long-chain-fatty-acid--CoA ligase - Saccharomyces cerevisiae; uncharacterized protein 1167203 4988907 An16g05150 Aspergillus niger uncharacterized protein XP_001397823.1 1164844 D 5061 CDS An16g05160 84593418 join(1168613..1168717,1168763..1168846,1169344..1169491,1169580..1170104,1170130..1170205,1170402..1170519) V 1 NT_166531.1 hypothetical protein 1170519 84593418 An16g05160 Aspergillus niger hypothetical protein XP_059606549.1 1168613 D 5061 CDS An16g05170 84593419 join(1170531..1170593,1170720..1170977,1171087..1171136,1171355..1171424,1171674..1171814) V 1 NT_166531.1 hypothetical protein 1171814 84593419 An16g05170 Aspergillus niger hypothetical protein XP_059606550.1 1170531 D 5061 CDS An16g05180 84593420 complement(join(1171817..1171913,1172094..1172136,1172229..1172287,1172913..1173130)) V 1 NT_166531.1 hypothetical protein 1173130 84593420 An16g05180 Aspergillus niger hypothetical protein XP_059606551.1 1171817 R 5061 CDS An16g05190 4988911 complement(join(1173388..1174898,1174990..1175038,1175122..1175160)) V 1 NT_166531.1 Title: strong similarity to hypothetical related to meiosis-specific protein NDT80 - Neurospora crassa; uncharacterized protein 1175160 4988911 An16g05190 Aspergillus niger uncharacterized protein XP_001397827.3 1173388 R 5061 CDS An16g05200 84593421 join(1175766..1175811,1175918..1175927,1176208..1176331,1176428..1176472) V 1 NT_166531.1 hypothetical protein 1176472 84593421 An16g05200 Aspergillus niger hypothetical protein XP_059606552.1 1175766 D 5061 CDS An16g05210 84593422 complement(join(1178091..1178349,1178391..1178475,1178518..1178591,1178930..1179004,1179091..1179124,1179228..1179303)) V 1 NT_166531.1 hypothetical protein 1179303 84593422 An16g05210 Aspergillus niger hypothetical protein XP_059606553.1 1178091 R 5061 CDS An16g05220 84593423 complement(join(1179383..1179514,1179583..1179694,1179748..1179822,1179900..1180084)) V 1 NT_166531.1 hypothetical protein 1180084 84593423 An16g05220 Aspergillus niger hypothetical protein XP_059606554.1 1179383 R 5061 CDS An16g05230 84593424 join(1180866..1181059,1181146..1181185,1181266..1181308,1181399..1181517,1181593..1181684,1181765..1181888,1182007..1182069) V 1 NT_166531.1 hypothetical protein 1182069 84593424 An16g05230 Aspergillus niger hypothetical protein XP_059606555.1 1180866 D 5061 CDS An16g05240 84593425 complement(join(1182124..1182237,1182362..1182413,1182624..1182746,1182867..1183033)) V 1 NT_166531.1 hypothetical protein 1183033 84593425 An16g05240 Aspergillus niger hypothetical protein XP_059606556.1 1182124 R 5061 CDS An16g05250 84593426 complement(join(1183288..1183423,1183482..1183516,1183569..1183702,1183784..1183823)) V 1 NT_166531.1 hypothetical protein 1183823 84593426 An16g05250 Aspergillus niger hypothetical protein XP_059606557.1 1183288 R 5061 CDS An16g05260 4988918 complement(join(1184552..1184604,1184733..1184904,1185243..1185867,1185972..1185988)) V 1 NT_166531.1 Title: strong similarity to eukaryotic translation initiation factor 3 subunit p42 - Homo sapiens; See PMID 9973622; uncharacterized protein 1185988 4988918 An16g05260 Aspergillus niger uncharacterized protein XP_001397834.1 1184552 R 5061 CDS An16g05270 4988919 complement(join(1186472..1186671,1186735..1186882,1186932..1186992,1187070..1188154)) V 1 NT_166531.1 Title: strong similarity to hypothetical protein hsp70 - Neurospora crassa; uncharacterized protein 1188154 4988919 An16g05270 Aspergillus niger uncharacterized protein XP_001397835.3 1186472 R 5061 CDS An16g05280 4988920 join(1188883..1188891,1188965..1190236) V 1 NT_166531.1 hypothetical protein 1190236 4988920 An16g05280 Aspergillus niger hypothetical protein XP_059606558.1 1188883 D 5061 CDS An16g05290 4988921 complement(join(<1190680..1191766,1191824..1192040,1192136..1192363)) V 1 NT_166531.1 Remark: a putative sequencing error results in an frameshift.; Title: strong similarity to hypothetical purine-cytosine permease Fcy2 - Saccharomyces cerevisiae [putative frameshift]; putative frameshift; uncharacterized protein 1192363 4988921 An16g05290 Aspergillus niger uncharacterized protein XP_059606559.1 1190680 R 5061 CDS An16g05300 84593427 join(1192636..1192812,1192920..1193181,1193228..1193353,1193470..1193510,1193606..1193800,1193910..1194104) V 1 NT_166531.1 hypothetical protein 1194104 84593427 An16g05300 Aspergillus niger hypothetical protein XP_059606560.1 1192636 D 5061 CDS An16g05310 4988923 complement(join(1196061..1196192,1196317..1196662,1196724..1197543,1197597..1197791,1198007..1198085)) V 1 NT_166531.1 Title: strong similarity to GABA permease gabA -Aspergillus nidulans; See PMID 10320578; uncharacterized protein 1198085 4988923 An16g05310 Aspergillus niger uncharacterized protein XP_059604797.1 1196061 R 5061 CDS An16g05320 4988924 join(1198536..1199485,1199543..1200041) V 1 NT_166531.1 Title: strong similarity to cytochrome P450 trichodiene oxygenase TRI4 - Fusarium sporortrichoides; See PMID 7651333; See PMID 11352533; uncharacterized protein 1200041 4988924 An16g05320 Aspergillus niger uncharacterized protein XP_001397840.1 1198536 D 5061 CDS An16g05330 4988925 complement(join(1200132..1200438,1200489..1200937)) V 1 NT_166531.1 Title: strong similarity to hypothetical protein in haematococca pathogenicity cluster PEP2 - Nectria haematococca; uncharacterized protein 1200937 4988925 An16g05330 Aspergillus niger uncharacterized protein XP_001397841.1 1200132 R 5061 CDS An16g05340 4988926 complement(join(1202470..1202760,1202810..1203311,1203379..1203640,1203734..1203746)) V 1 NT_166531.1 Catalytic activity: NADH specific Enoyl-[acyl-carrier protein] reductases convert acyl-[acyl-carrier protein] + NAD(+) to trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.; Complex: S. pneumoniae fabK contains a FAD-binding domain and is NADH specific.; Function: S. pneumoniae fabK is involved in fatty-acid biosynthesis and catalyses the reduction of enoyl-acyl-carrier-protein (ACP) during each cycle of fatty-acid elongation.; Title: similarity to trans-2-enoyl-ACP reductase II fabK - Streptococcus pneumoniae; See PMID 10910344; uncharacterized protein 1203746 4988926 An16g05340 Aspergillus niger uncharacterized protein XP_001397842.1 1202470 R 5061 CDS An16g05350 4988927 join(1204756..1204953,1205004..1205212,1205266..>1206254) V 1 NT_166531.1 Catalytic activity: bifunctional folic acid synthesis protein of P. sativum catalyzes the reactions ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine <=> AMP + 2-amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pterid ine (EC 2. 7. 6. 3) and 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate <=> diphosphate + dihydropteroate (EC 2. 5. 1. 15).; Pathway: bifunctional folic acid synthesis protein of P. sativum catalyzes the first steps in folate synthesis.; Remark: the A. niger ORF contains a putaive sequncing error at position 7312.; Title: strong similarity to precursor of bifunctional folic acid synthesis protein - Pisum sativum [putative frameshift]; putative frameshift; See PMID 9118956; uncharacterized protein 1206254 4988927 An16g05350 Aspergillus niger uncharacterized protein XP_059604798.1 1204756 D 5061 CDS An16g05360 84593428 complement(1206761..1207516) V 1 NT_166531.1 hypothetical protein 1207516 84593428 An16g05360 Aspergillus niger hypothetical protein XP_059604799.1 1206761 R 5061 CDS An16g05370 4988929 complement(join(1208164..1208192,1208246..1208563,1208622..1209316,1209375..1209558,1209618..1209787,1209888..1209907)) V 1 NT_166531.1 Function: Glo3p of S. cerevisiae is involved in transition from stationary to proliferative phase.; Title: similarity to zinc-finger protein Glo3 -Saccharomyces cerevisiae; nucleus; See PMID 8070409; uncharacterized protein 1209907 4988929 An16g05370 Aspergillus niger uncharacterized protein XP_059604800.1 1208164 R 5061 CDS An16g05380 4988930 join(1210645..1210953,1211019..1211203,1211271..1211325,1211388..1211487,1211552..1211633,1211742..1211787) V 1 NT_166531.1 Title: similarity to hypothetical membrane protein YGR033c - Saccharomyces cerevisiae; uncharacterized protein 1211787 4988930 An16g05380 Aspergillus niger uncharacterized protein XP_001397846.3 1210645 D 5061 CDS An16g05390 4988931 complement(join(1211892..1212494,1212558..1213163,1213222..1213326,1213393..1213437)) V 1 NT_166531.1 Remark: the A. niger protein also shows weak similarity to the mandelate racemase of Pseudomonas putida and contains a mandelate racemase BLOCKS and PFAM domain.; Title: strong similarity to hypothetical protein RTS-beta - Homo sapiens; uncharacterized protein 1213437 4988931 An16g05390 Aspergillus niger uncharacterized protein XP_001397847.1 1211892 R 5061 CDS An16g05400 4988932 complement(join(1214076..1214168,1214240..1215114,1215190..1215763,1215811..1216406,1216461..1216523,1216598..1216616)) V 1 NT_166531.1 Title: similarity to hypothetical protein SPBC839.10 - Schizosaccharomyces pombe; uncharacterized protein 1216616 4988932 An16g05400 Aspergillus niger uncharacterized protein XP_059604801.1 1214076 R 5061 CDS An16g05410 84593429 join(1217779..1217842,1217955..1218086,1218162..1218203,1218293..1218411) V 1 NT_166531.1 hypothetical protein 1218411 84593429 An16g05410 Aspergillus niger hypothetical protein XP_059604802.1 1217779 D 5061 CDS An16g05420 4988934 join(1218699..1219198,1219256..1220417) V 1 NT_166531.1 Function: Pgi1p of S. cerevisiae converts glucose-6-phosphate to fructose-6-phosphate.; Phenotype: pgi null mutants are growth-inhibited by glucose.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to glucose-6-phosphate isomerase Pgi1 - Saccharomyces cerevisiae; See PMID 3072254; uncharacterized protein 1220417 4988934 An16g05420 Aspergillus niger uncharacterized protein XP_001397850.1 1218699 D 5061 CDS An16g05430 4988935 join(1220816..1220991,1221036..1221090,1221166..1222004,1222060..1222156) V 1 NT_166531.1 Title: strong similarity to hypothetical protein EAA58013.1 - Aspergillus nidulans; uncharacterized protein 1222156 4988935 An16g05430 Aspergillus niger uncharacterized protein XP_059604803.1 1220816 D 5061 CDS An16g05440 4988936 complement(1222288..1222944) V 1 NT_166531.1 mitochondrial 37S ribosomal protein bS21m 1222944 4988936 An16g05440 Aspergillus niger mitochondrial 37S ribosomal protein bS21m XP_001397852.1 1222288 R 5061 CDS An16g05450 4988937 join(1223308..1223422,1223492..1223802) V 1 NT_166531.1 Remark: the A. niger protein also shows weak similarity to arsenate reductase of S. cerevisiae and to human protein-tyrosine-phosphatase cdc25B.; Title: similarity to hypothetical protein YGR203w -Saccharomyces cerevisiae; uncharacterized protein 1223802 4988937 An16g05450 Aspergillus niger uncharacterized protein XP_001397853.1 1223308 D 5061 CDS An16g05460 4988938 complement(join(1224024..1224916,1224976..1225177,1225240..1225509,1225563..1225736)) V 1 NT_166531.1 Remark: the A. niger protein also shows similarity to the uncharacterized A. thaliana protein from patent EP1033405-A2.; Title: similarity to hypothetical protein MZN14.19 -Arabidopsis thaliana; uncharacterized protein 1225736 4988938 An16g05460 Aspergillus niger uncharacterized protein XP_001397854.3 1224024 R 5061 CDS An16g05470 84593430 complement(join(1226139..1226495,1226545..1226937,1227012..1227151,1227214..1227262)) V 1 NT_166531.1 Title: weak similarity to hypothetical RNA-binding protein - Schizosaccharomyces pombe; uncharacterized protein 1227262 84593430 An16g05470 Aspergillus niger uncharacterized protein XP_059604804.1 1226139 R 5061 CDS An16g05480 84593431 join(1227942..1228214,1228283..1228355,1228464..1228556,1228739..1228966,1229103..1229227) V 1 NT_166531.1 Title: weak similarity to calcium/calmodulin-dependent protein kinase IV - Xenopus laevis; uncharacterized protein 1229227 84593431 An16g05480 Aspergillus niger uncharacterized protein XP_059604805.1 1227942 D 5061 CDS An16g05490 84593432 join(1229436..1229538,1229616..1229941) V 1 NT_166531.1 hypothetical protein 1229941 84593432 An16g05490 Aspergillus niger hypothetical protein XP_059604806.1 1229436 D 5061 CDS An16g05500 4988942 join(1230531..1230693,1230766..1230844,1230897..1232505) V 1 NT_166531.1 hypothetical protein 1232505 4988942 An16g05500 Aspergillus niger hypothetical protein XP_059604807.1 1230531 D 5061 CDS An16g05510 4988943 complement(join(1232720..1233166,1233264..1233678,1233739..1234526)) V 1 NT_166531.1 Function: galactosyltransferase-associated protein kinase of M. musculus acts as a negative regulator of the normal cell cycle progression. In vitro, this protein kinase has been shown to phosphorylate a number of substrates, including histone H1, casein, and galactosyltransferase. Galactosyltransferase-associated protein kinase of M. musculus may function in regulating proliferation by the phosphorylation and subsequent plasma membrane targeting of galactosyltransferase.; Similarity: galactosyltransferase-associated protein kinase of M. musculus shows similarity with the conserved catalytic domains of ser/thr-protein kinases. It belongs to the cdc2/cdkx subfamily.; Title: similarity to galactosyltransferase-associated protein kinase - Mus musculus; deleted EC_number 2.7.1.37; See PMID 2069872; uncharacterized protein 1234526 4988943 An16g05510 Aspergillus niger uncharacterized protein XP_001397859.3 1232720 R 5061 CDS An16g05520 4988944 join(1234624..1234641,1234704..1234776,1234823..1234957,1235017..1235534) V 1 NT_166531.1 Function: Lys7 of S. cerevisiae is required for the incorporation of copper specifically into superoxide dismutase Sod1p.; Phenotype: lys7 deletion mutant shows sensitivity to superoxide generating drugs, to light irradiation, and diminution of calcineurin activity.; Title: similarity to copper chaperone Lys7 -Saccharomyces cerevisiae; cytoplasm; See PMID 9295278; uncharacterized protein 1235534 4988944 An16g05520 Aspergillus niger uncharacterized protein XP_001397860.1 1234624 D 5061 CDS An16g05530 84593433 complement(join(1235577..1235594,1235661..1235927,1236170..1236289,1236507..1236596)) V 1 NT_166531.1 hypothetical protein 1236596 84593433 An16g05530 Aspergillus niger hypothetical protein XP_059604808.1 1235577 R 5061 CDS An16g05540 84593434 complement(join(1236775..1236825,1236908..1236956,1237041..1237146,1237263..1237372,1237509..1237605,1237690..1237726,1237812..1237844)) V 1 NT_166531.1 hypothetical protein 1237844 84593434 An16g05540 Aspergillus niger hypothetical protein XP_059604809.1 1236775 R 5061 CDS An16g05550 4988947 join(1237953..1237967,1238016..1238165,1238215..1238550,1238596..1239642,1239699..1239728) V 1 NT_166531.1 Function: human neutrophil oxidase factor is involved in the superoxide production by phagocytic cells.; Remark: only the N-terminal half of the A. niger protein is similar to the N-terminal half of the human neutrophil oxidase factor.; Title: similarity to neutrophil oxidase factor -Homo sapiens; See PMID 1692159; uncharacterized protein 1239728 4988947 An16g05550 Aspergillus niger uncharacterized protein XP_001397863.1 1237953 D 5061 CDS An16g05560 4988948 join(1239944..1240066,1240136..1240849) V 1 NT_166531.1 Title: strong similarity to hypothetical protein EAA58022.1 - Aspergillus nidulans; uncharacterized protein 1240849 4988948 An16g05560 Aspergillus niger uncharacterized protein XP_001397864.3 1239944 D 5061 CDS An16g05570 4988949 complement(join(1241381..1242328,1242380..1242511,1242593..1242772)) V 1 NT_166531.1 Catalytic activity: aspartate aminotransferases convert L-aspartate + 2-oxoglutarate to oxaloacetate + L-glutamate.; Function: aspartate aminotransferases are involved in amino acid and nitrogen metabolism.; Title: strong similarity to aspartate transaminase -Sus scrofa; See PMID 2653435; uncharacterized protein 1242772 4988949 An16g05570 Aspergillus niger uncharacterized protein XP_059604810.1 1241381 R 5061 CDS An16g05580 4988950 complement(join(1244711..1245092,1245150..1245696,1245747..1246146,1246197..1246532)) V 1 NT_166531.1 Remark: the A. niger protein also shows similarity to the RING zinc finger protein of Gallus gallus and contains a zinc finger PFAM domain.; Title: similarity to hypothetical protein B24P11.150 - Neurospora crassa; nucleus; uncharacterized protein 1246532 4988950 An16g05580 Aspergillus niger uncharacterized protein XP_001397866.1 1244711 R 5061 CDS An16g05590 84593435 join(1247049..1247090,1247341..1247517) V 1 NT_166531.1 Title: strong similarity to EST an_1462 -Aspergillus niger; uncharacterized protein 1247517 84593435 An16g05590 Aspergillus niger uncharacterized protein XP_059604811.1 1247049 D 5061 CDS An16g05600 84593436 join(1247853..1248004,1248103..1248315,1248386..1248480,1248847..1249029,1249103..1249320) V 1 NT_166531.1 hypothetical protein 1249320 84593436 An16g05600 Aspergillus niger hypothetical protein XP_059604812.1 1247853 D 5061 CDS An16g05610 84593437 join(1250474..1250513,1250552..1250667) V 1 NT_166531.1 hypothetical protein 1250667 84593437 An16g05610 Aspergillus niger hypothetical protein XP_059604813.1 1250474 D 5061 CDS An16g05620 84593438 join(1251277..1251360,1251518..1251538,1251611..1251703) V 1 NT_166531.1 hypothetical protein 1251703 84593438 An16g05620 Aspergillus niger hypothetical protein XP_059604814.1 1251277 D 5061 CDS An16g05630 84593439 join(1252384..1252525,1252695..1252843) V 1 NT_166531.1 hypothetical protein 1252843 84593439 An16g05630 Aspergillus niger hypothetical protein XP_059604815.1 1252384 D 5061 CDS An16g05640 4988956 join(1254126..1254220,1254476..1254785,1254850..1256075,1256108..1256390) V 1 NT_166531.1 Title: similarity to hypothetical protein encoded by An11g07160 - Aspergillus niger; uncharacterized protein 1256390 4988956 An16g05640 Aspergillus niger uncharacterized protein XP_059604816.1 1254126 D 5061 CDS An16g05650 84593440 1257176..1258390 V 1 NT_166531.1 Title: strong similarity to hypothetical protein SC8F11.11c - Streptomyces coelicolor; uncharacterized protein 1258390 84593440 An16g05650 Aspergillus niger uncharacterized protein XP_059604817.1 1257176 D 5061 CDS An16g05660 4988958 join(1258626..1260577,1260647..1260668,1261075..1261155,1261284..1261304) V 1 NT_166531.1 Catalytic activity: betA of E. coli catalyzes the reaction of choline + acceptor = betaine aldehyde + reduced acceptor.; Function: betA of E. coli catalyzes the oxidation of choline to betaine aldehyde & betaine aldehyde to glycine betaine at the same rate. It is independent of soluble cofactors, and probably electron-transfer-linked.; Pathway: betA of E. coli is involved is the osmoregulatory choline-glycine betaine pathway.; Similarity: betA of E. coli belongs to the GMC oxidoreductases family.; Title: similarity to choline dehydrogenase betA -Escherichia coli; See PMID 1956285; uncharacterized protein 1261304 4988958 An16g05660 Aspergillus niger uncharacterized protein XP_001397874.3 1258626 D 5061 CDS An16g05670 84593441 complement(join(1261667..1263562,1263616..1264444,1264496..1264790,1264854..1266024,1266068..1266196,1266372..1266692)) V 1 NT_166531.1 hypothetical protein 1266692 84593441 An16g05670 Aspergillus niger hypothetical protein XP_059604818.1 1261667 R 5061 CDS An16g05680 84593442 complement(join(1267902..1268004,1268075..1268218,1268342..1268544,1268630..1268751,1268824..1269228,1269390..1269460,1269670..1269767)) V 1 NT_166531.1 hypothetical protein 1269767 84593442 An16g05680 Aspergillus niger hypothetical protein XP_059604819.1 1267902 R 5061 CDS An16g05690 4988961 complement(join(1270365..1270515,1270590..1270645,1270693..1271063,1271121..1271184,1271232..1271359,1271409..1271499)) V 1 NT_166531.1 Function: faeA of A. tubingensis is involved in degradation of complex cell wall polysaccharides.; Remark: the ORF encoded protein also shows similarity to methyl ferulate esterase FEA of A. niger from patent WO9814594-A2. FAE can cleave the ester linkage of phenolic esters.; Title: similarity to ferulic acid esterase A faeA -Aspergillus tubingensis; See PMID 9406381; uncharacterized protein 1271499 4988961 An16g05690 Aspergillus niger uncharacterized protein XP_059604820.1 1270365 R 5061 CDS An16g05700 84593443 complement(join(1271874..1271988,1272072..1272222,1272442..1272517,1272622..1272996,1273080..1273127)) V 1 NT_166531.1 hypothetical protein 1273127 84593443 An16g05700 Aspergillus niger hypothetical protein XP_059604821.1 1271874 R 5061 CDS An16g05710 4988963 complement(join(1273391..1273732,1273785..1274384,1274461..1274819,1274873..1275068)) V 1 NT_166531.1 Function: N. haematococca detoxify the antibioticum pisatin utilizing the cytochrome P450 monooxygenase PADT9.; Remark: the A. niger protein also shows strong similarity to other cytochrome P450 proteins.; Similarity: N. haematococca PDAT9 has been assigned to a new cytochrome P450 family, CYP57.; Title: strong similarity to cytochrome P450 pisatin demethylase PDAT9 - Nectria haematococca; See PMID 9501474; See PMID 9683653; uncharacterized protein 1275068 4988963 An16g05710 Aspergillus niger uncharacterized protein XP_001397879.1 1273391 R 5061 CDS An16g05720 84593444 complement(join(1276116..1276245,1276323..1276436,1276522..1276604)) V 1 NT_166531.1 hypothetical protein 1276604 84593444 An16g05720 Aspergillus niger hypothetical protein XP_059604822.1 1276116 R 5061 CDS An16g05730 4988965 complement(join(1277472..1278015,1278085..1278563,1278623..1278661,1278705..1278749)) V 1 NT_166531.1 Function: Pth11p of M. grisea functions as an upstream effector of appressorium differentiation in response to host surface recognition.; Function: Pth11p of M. grisea is involved in the response to both host cutin monomers and contact surface hydrophobicity.; Localization: Pth11p of M. grisea functions at the cell cortex, but is also found in the vacuolar membrane.; Remark: the A. niger protein is only half the size of Pth11p.; Repression: Pth11p of M. grisea is probably downregulated by shunting the surface receptor protein to the vacuole by endocytosis.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529; uncharacterized protein 1278749 4988965 An16g05730 Aspergillus niger uncharacterized protein XP_059604823.1 1277472 R 5061 CDS An16g05740 4988966 complement(join(1279569..1279637,1279729..1280082,1280185..1280560,1280908..1280978,1281035..1281055)) V 1 NT_166531.1 Title: weak similarity to 2-hydroxy-6-ketonona-2,4-dienoate hydrolase hppC - Rhodococcus globerulus; uncharacterized protein 1281055 4988966 An16g05740 Aspergillus niger uncharacterized protein XP_001397882.3 1279569 R 5061 CDS An16g05750 4988967 complement(join(1281579..1282994,1283036..1283263)) V 1 NT_166531.1 Function: heterologous expression of rice OsMST3 in the yeast S. cerevisiae indicated that OsMST3 has transport activity for some monosaccharides in an energy-dependent H+ co-transport manner.; Title: strong similarity to monosaccharide transporter 3 OsMST3 - Oryza sativa; See PMID 11038054; uncharacterized protein 1283263 4988967 An16g05750 Aspergillus niger uncharacterized protein XP_059604824.1 1281579 R 5061 CDS An16g05760 4988968 complement(join(1284236..1286066,1286122..1286567,1286626..1286727)) V 1 NT_166531.1 Catalytic activity: aconitase catalyzes the reaction of citrate to isocitrate and H2O.; Remark: aconitase has an active (4fe-4s) and an inactive (3fe-4s) form. The active (4fe-4s) cluster is part of the catalytic site that interconverts citrate,cis-aconitase, and isocitrate.; Similarity: aconitate hydratase (aconitase) belongs to the aconitase/ipm isomerase family.; Title: strong similarity to mitochondrial aconitate hydratase Aco1 - Saccharomyces cerevisiae; See PMID 10490611; See PMID 1972545; uncharacterized protein 1286727 4988968 An16g05760 Aspergillus niger uncharacterized protein XP_059604825.1 1284236 R 5061 CDS An16g05770 4988969 join(1287059..1287112,1287166..1287792) V 1 NT_166531.1 Function: L. pneumophila DotA is one of the factors inhibiting the fusion of the endosome to the lysosome.; Remark: an alternative name for L. pneumophila dotA is dlpA.; Remark: the A. niger protein is only half the size of DotA from L. pneumophila. It shows similarity to the C-terminal half of DotA.; Title: similarity to inhibitor of endosome-lysosome fusion DotA - Legionella pneumophila; endosome; See PMID 9632267; See PMID 11207624; uncharacterized protein 1287792 4988969 An16g05770 Aspergillus niger uncharacterized protein XP_001397885.1 1287059 D 5061 CDS An16g05780 84593445 complement(join(1288019..1288188,1288263..1288735,1288856..1289215,1289267..1289856,1289906..1290401,1290467..1290564,1290628..1290888)) V 1 NT_166531.1 Function: UaY of A. nidulans acts as a transcriptional activator of the uapA gene.; Similarity: contains a fungal-type Zn(2)-Cys(6) binuclear cluster DNA-binding domain.; Title: similarity to positive regulator of purine utilisation uaY - Aspergillus nidulans; See PMID 7729421; uncharacterized protein 1290888 84593445 An16g05780 Aspergillus niger uncharacterized protein XP_059604826.1 1288019 R 5061 CDS An16g05790 4988971 join(1291980..1292061,1292136..1292832,1292884..1293052) V 1 NT_166531.1 Catalytic activity: 2-pyrone-4,6-dicarboxylate + H2O = oxalomesaconate.; Pathway: pcmC of A. keyseri is involved in the phthalate catabolic pathway.; Similarity: the C-terminal half shows very strong homology to a hypothetical protein fragment of A. nidulans.; Title: strong similarity to 2-pyrone-4,6-dicarboxylate hydrolase pcmC - Arthrobacter keyseri; See PMID 11371533; uncharacterized protein 1293052 4988971 An16g05790 Aspergillus niger uncharacterized protein XP_001397887.1 1291980 D 5061 CDS An16g05800 84593446 join(1293384..1293563,1293648..1293827) V 1 NT_166531.1 hypothetical protein 1293827 84593446 An16g05800 Aspergillus niger hypothetical protein XP_059604827.1 1293384 D 5061 CDS An16g05810 4988973 join(1293958..1294592,1294645..1294922,1294974..1295827) V 1 NT_166531.1 Function: CRG1 of C. nicotianae confers resistance to the photosensitizing toxin cercosporin by a mechanism yet to be determined.; Title: similarity to cercosporin resistance protein CRG1 - Cercospora nicotianae; See PMID 10517336; uncharacterized protein 1295827 4988973 An16g05810 Aspergillus niger uncharacterized protein XP_001397889.3 1293958 D 5061 CDS An16g05820 84593447 complement(join(1295995..1296043,1296083..1296548,1296595..1296631,1296792..1297028)) V 1 NT_166531.1 hypothetical protein 1297028 84593447 An16g05820 Aspergillus niger hypothetical protein XP_059604828.1 1295995 R 5061 CDS An16g05830 84593448 join(1297754..1297837,1297998..1298128,1298503..1298628,1298715..1299000,1299061..1299150,1299488..1299557,1299654..1299694) V 1 NT_166531.1 hypothetical protein 1299694 84593448 An16g05830 Aspergillus niger hypothetical protein XP_059604829.1 1297754 D 5061 CDS An16g05840 4988976 join(1300741..1301140,1301216..1301439,1301499..1302143,1302247..1303152,1303212..1304018) V 1 NT_166531.1 Function: pmaA of A. nidulans is required for proton transport against the transmembrane pH gradient.; Title: strong similarity to plasma membrane H(+)-ATPase pmaA - Aspergillus nidulans; plasma membrane; See PMID 11131024; uncharacterized protein 1304018 4988976 An16g05840 Aspergillus niger uncharacterized protein XP_001397892.1 1300741 D 5061 CDS An16g05850 84593449 complement(join(1304507..1304590,1304709..1304797,1304892..1304953,1305042..1305123,1305215..1305494)) V 1 NT_166531.1 hypothetical protein 1305494 84593449 An16g05850 Aspergillus niger hypothetical protein XP_059604830.1 1304507 R 5061 CDS An16g05860 84593450 join(1305961..1306283,1306352..1306435,1306495..1306613,1306749..1306882) V 1 NT_166531.1 hypothetical protein 1306882 84593450 An16g05860 Aspergillus niger hypothetical protein XP_059604831.1 1305961 D 5061 CDS An16g05870 84593451 join(1307197..1308057,1308335..1308417,1308487..1308799) V 1 NT_166531.1 hypothetical protein 1308799 84593451 An16g05870 Aspergillus niger hypothetical protein XP_059604832.1 1307197 D 5061 CDS An16g05880 4988980 complement(join(1309822..1309881,1309936..1311291)) V 1 NT_166531.1 Function: Mtr1 of N. crassa is required for the cellular uptake of neutral aliphatic and aromatic amino acids.; Title: strong similarity to neutral amino acid permease mtr - Neurospora crassa; See PMID 7604041; See PMID 8001794; uncharacterized protein 1311291 4988980 An16g05880 Aspergillus niger uncharacterized protein XP_001397896.1 1309822 R 5061 CDS An16g05890 84593452 complement(join(1312396..1312640,1312818..1313094)) V 1 NT_166531.1 hypothetical protein 1313094 84593452 An16g05890 Aspergillus niger hypothetical protein XP_059604833.1 1312396 R 5061 CDS An16g05900 84593453 complement(join(1313175..1313404,1313501..1313585,1313661..1313734,1313775..1313913)) V 1 NT_166531.1 hypothetical protein 1313913 84593453 An16g05900 Aspergillus niger hypothetical protein XP_059604834.1 1313175 R 5061 CDS An16g05910 4988983 complement(join(1315021..1315909,1315973..1316404,1316475..1316653)) V 1 NT_166531.1 Catalytic activity: Cholesterol + NADPH + O2 = 7-alpha-hydroxycholesterol + NADP(+) + H2O.; Pathway: CYP7 of S. scrofa catalyzes the rate-limiting step in bile acid biosynthesis.; Similarity: belongs to the superfamily of cytochrome P450 monooxygenases.; Title: strong similarity to cholesterol 7alpha-hydroxylase CYP7 - Sus scrofa; See PMID 11013305; uncharacterized protein 1316653 4988983 An16g05910 Aspergillus niger uncharacterized protein XP_001397899.1 1315021 R 5061 CDS An16g05920 4988984 join(1317765..1317948,1318011..1318030,1318104..1318143,1318206..1318276,1318338..1318726,1318790..1318891,1318958..1319378) V 1 NT_166531.1 Title: weak similarity to integral membrane protein PTH11 from patent WO9913094-A2 - Magnaporthe grisea; uncharacterized protein 1319378 4988984 An16g05920 Aspergillus niger uncharacterized protein XP_001397900.1 1317765 D 5061 CDS An16g05930 4988985 1320324..1321226 V 1 NT_166531.1 Title: strong similarity to hypothetical protein encoded by An08g06890 - Aspergillus niger; uncharacterized protein 1321226 4988985 An16g05930 Aspergillus niger uncharacterized protein XP_001397901.1 1320324 D 5061 CDS An16g05940 4988986 complement(join(1321318..1321338,1321553..1321630,1321853..1323303,1323367..1323547)) V 1 NT_166531.1 Function: StcS of A. nidulans is involved in the conversion of versicolorin A to demethylsterigmatocystin.; Pathway: StcS of A. nidulans is involved in the sterigmatocystin biosynthesis.; Remark: sterigmatocystin is a polyketide-derived mycotoxin.; Similarity: belongs to the cytochrome P450 superfamily.; Title: strong similarity to cytochrome P450 monooxygenase stcS - Aspergillus nidulans; See PMID 10618248; See PMID 7486998; uncharacterized protein 1323547 4988986 An16g05940 Aspergillus niger uncharacterized protein XP_059604835.1 1321318 R 5061 CDS An16g05950 84593454 complement(join(1324161..1324259,1324401..1324785,1325286..1325368)) V 1 NT_166531.1 hypothetical protein 1325368 84593454 An16g05950 Aspergillus niger hypothetical protein XP_059604836.1 1324161 R 5061 CDS An16g05960 4988988 join(1327156..1328046,1328159..1328258,1328372..1328427) V 1 NT_166531.1 Similarity: also shows similarity to some hypothetical epoxide hydrolases.; Similarity: belongs to the alpha/beta hydrolase fold family.; Similarity: shows homology to the protein patent database entry PATENTPROT:AAY08565.; Title: similarity to hydrolase YGJL from patent WO9927081-A2 - Bacillus subtilis; uncharacterized protein 1328427 4988988 An16g05960 Aspergillus niger uncharacterized protein XP_001397904.3 1327156 D 5061 CDS An16g05970 4988989 complement(join(1328601..1329225,1329271..1330153,1330218..1330293)) V 1 NT_166531.1 Function: UGT2B11 of H. sapiens catalyzes the transfer of glucuronic acid to a wide range of exogenous and endogenous compounds including phenols derivatives,bilirubin, fatty acids and steroids.; Title: similarity to UDP-glucuronosyltransferase UGT2B11 - Homo sapiens; See PMID 9675083; uncharacterized protein 1330293 4988989 An16g05970 Aspergillus niger uncharacterized protein XP_059604837.1 1328601 R 5061 CDS An16g05980 84593455 join(1331291..1331374,1331446..1331706) V 1 NT_166531.1 hypothetical protein 1331706 84593455 An16g05980 Aspergillus niger hypothetical protein XP_059604838.1 1331291 D 5061 CDS An16g05990 84593456 complement(join(1331871..1332164,1332417..1332512)) V 1 NT_166531.1 Title: strong similarity to EST an_3135 -Aspergillus niger; uncharacterized protein 1332512 84593456 An16g05990 Aspergillus niger uncharacterized protein XP_059604839.1 1331871 R 5061 CDS An16g06000 84593457 complement(join(1332637..1332746,1332794..1332972,1333197..1333263,1333342..1333357)) V 1 NT_166531.1 hypothetical protein 1333357 84593457 An16g06000 Aspergillus niger hypothetical protein XP_059604840.1 1332637 R 5061 CDS An16g06010 4988993 join(1333406..1333454,1333511..1333889,1333953..1334162,1334347..1334491) V 1 NT_166531.1 Catalytic activity: 2-phospho-D-glycerate + 2,3-diphosphoglycerate = 3-phospho-D-glycerate + 2,3-diphosphoglycerate.; Similarity: also shows stronger similarity to a number of putative phosphoglycerate mutases from diverse species.; Title: similarity to phosphoglycerate mutase pgm -Zymomonas mobilis; See PMID 8320209; uncharacterized protein 1334491 4988993 An16g06010 Aspergillus niger uncharacterized protein XP_059604841.1 1333406 D 5061 CDS An16g06020 84593458 join(1334795..1334884,1335014..1335121,1335334..>1336131) V 1 NT_166531.1 Remark: the ORF is C-terminally truncated due to end of contig.; Similarity: the similarities are mainly based on repetetive structures.; Title: weak similarity to hypothetical protein CAD87780.1 - Danio rerio [truncated ORF]; uncharacterized protein 1336131 84593458 An16g06020 Aspergillus niger uncharacterized protein XP_059604842.1 1334795 D 5061 CDS An16g06030 84593459 join(<1336233..1336718,1336916..1336945) V 1 NT_166531.1 Remark: the ORF is N-terminally truncated due to contig border.; hypothetical protein [truncated ORF] 1336945 84593459 An16g06030 Aspergillus niger hypothetical protein [truncated ORF] XP_059604843.1 1336233 D 5061 CDS An16g06040 84593460 join(1338024..1338099,1338405..1338501,1338555..1338612) V 1 NT_166531.1 Remark: the ORF has an intron-exon structure, which is not typical for A. niger proteins and is only 76 amino acids long.; Title: questionable ORF; uncharacterized protein 1338612 84593460 An16g06040 Aspergillus niger uncharacterized protein XP_059604844.1 1338024 D 5061 CDS An16g06070 84593461 complement(join(1340686..1340941,1341026..1341687)) V 1 NT_166531.1 Function: PIP of B. coagulans has a higher activity toward small peptides (up to three residues), but very low activity for longer peptides.; Remark: PIP of B. coagulans has no activity on hydroxyproline beta-naphtylamide.; Title: strong similarity to prolyl aminopeptidase PIP - Bacillus coagulans; See PMID 1459939; uncharacterized protein 1341687 84593461 An16g06070 Aspergillus niger uncharacterized protein XP_059604845.1 1340686 R 5061 CDS An16g06080 4989000 join(1342419..1342577,1342627..1343058,1343119..1343230,1343318..1343695,1343963..1343988) V 1 NT_166531.1 hypothetical protein 1343988 4989000 An16g06080 Aspergillus niger hypothetical protein XP_059604846.1 1342419 D 5061 CDS An16g06090 4989001 join(1344530..1344707,1344914..1344998,1345055..1345137,1345197..1345594,1345656..1346208,1346272..1346522) V 1 NT_166531.1 Phenotype: disruption of the HNM1 locus in S. cerevisiae completely abolished the choline transport activity, indicating that the HNM1 product is the sole choline transporter in yeast.; Remark: HNM1 of S. cerevisiae is also called CTR1.; Repression: the abundance of CTR mRNA in S. cerevisiae significantly decreased on incubation of cells with a combination of choline and myo-inositol; the CTR mRNA level was high in the exponential growth phase but decreased dramatically when cells entered the stationary phase.; Similarity: the ORF shows similarity to several amino acid permeases from different species.; Title: strong similarity to choline permease Hnm1 -Saccharomyces cerevisiae; See PMID 1878995; See PMID 2203793; See PMID 2249250; uncharacterized protein 1346522 4989001 An16g06090 Aspergillus niger uncharacterized protein XP_059604847.1 1344530 D 5061 CDS An16g06100 4989002 complement(join(1346765..1346851,1346947..1347138,1347200..1347310,1347374..1347527,1347616..1347689)) V 1 NT_166531.1 Catalytic activity: glutathione S-transferases catalyse RX + glutathione <=> HX + R-S-glutathione.; Function: GST1 of A. suum is facilitating the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophils and can also function as GSH peroxidase.; Title: similarity to glutathione S-transferase GST1 - Ascaris suum; uncharacterized protein 1347689 4989002 An16g06100 Aspergillus niger uncharacterized protein XP_001397916.1 1346765 R 5061 CDS An16g06120 4989004 complement(join(1350576..1351282,1351337..1352065,1352112..1352164,1352200..1352237,1352293..1352370)) V 1 NT_166531.1 Similarity: the ORF encoded protein and Gel3 from Aspergillus fumigatus belong to the fungal Gas1 protein family.; Title: strong similarity to glycosylphosphatidylinositol-anchored beta(1-3)glucanosyltransferase gel3 - Aspergillus fumigatus; plasma membrane; See PMID 10769178; uncharacterized protein 1352370 4989004 An16g06120 Aspergillus niger uncharacterized protein XP_059604848.1 1350576 R 5061 CDS An16g06130 84593462 complement(join(1353096..1353337,1353383..1353449,1353885..1353939,1354022..1354131)) V 1 NT_166531.1 Title: questionable ORF; uncharacterized protein 1354131 84593462 An16g06130 Aspergillus niger uncharacterized protein XP_059604849.1 1353096 R 5061 CDS An16g06140 4989006 1354329..1355426 V 1 NT_166531.1 Similarity: the C-terminal part of the predicted protein is constituted by low-complexity repeats producing a lot of non significant BLASTP matches.; Similarity: the similarity to B24P11. 210 of N. crassa involves only the N-terminal two thirds of the predicted protein.; Title: strong similarity to hypothetical protein B24P11.210 - Neurospora crassa; uncharacterized protein 1355426 4989006 An16g06140 Aspergillus niger uncharacterized protein XP_001397919.1 1354329 D 5061 CDS An16g06160 84593463 complement(join(1356257..1356354,1356429..1357551)) V 1 NT_166531.1 Similarity: the similarity to D. melanogaster CG12065 involves only a short N-terminal fragment of the predicted protein.; Title: weak similarity to polypeptide SEQ ID NO:1833 from patent WO200171042-A2 - Drosophila melanogaster; uncharacterized protein 1357551 84593463 An16g06160 Aspergillus niger uncharacterized protein XP_059604850.1 1356257 R 5061 CDS An16g06170 4989009 complement(join(1358304..1358864,1358919..1359212)) V 1 NT_166531.1 hypothetical protein 1359212 4989009 An16g06170 Aspergillus niger hypothetical protein XP_001397921.1 1358304 R 5061 CDS An16g06180 84593464 join(1359597..1359608,1359731..1360072) V 1 NT_166531.1 hypothetical protein 1360072 84593464 An16g06180 Aspergillus niger hypothetical protein XP_059604851.1 1359597 D 5061 CDS An16g06190 4989011 complement(join(1360338..1360999,1361055..1361423,1361475..1361626,1361680..1361796,1361846..1361895,1361972..1362118)) V 1 NT_166531.1 Function: GIT1 of S. cerevisiae is required for uptake of glycerophosphoinositol.; Localization: GIT1 of S. cerevisiae is probably located on the plasma membrane, although the subcellular localization has not been experimentally shown.; Remark: GIT1 of S. cerevisiae is also known as YCR098c.; Title: strong similarity to glycerophosphoinositol transporter Git1 - Saccharomyces cerevisiae; See PMID 8720066; See PMID 9299703; See PMID 9348664; See PMID 9691030; uncharacterized protein 1362118 4989011 An16g06190 Aspergillus niger uncharacterized protein XP_001397923.1 1360338 R 5061 CDS An16g06200 4989012 complement(join(1362904..1363414,1363471..1363828,1363947..1364283,1364337..1364784,1364886..1365076)) V 1 NT_166531.1 Remark: the predicted ORF encodes a probable transcriptional regulator of the fungal binuclear zinc cluster type.; Title: weak similarity to regulator protein qutA -Aspergillus nidulans; See PMID 3313276; See PMID 8581174; See PMID 8704987; uncharacterized protein 1365076 4989012 An16g06200 Aspergillus niger uncharacterized protein XP_059604852.1 1362904 R 5061 CDS An16g06210 4989013 complement(join(1365647..1366151,1366230..1366562,1366629..1366825)) V 1 NT_166531.1 Catalytic activity: a nitrile + H2O = a carboxylate + NH3.; Catalytic activity: acts on a wide range of aromatic nitriles including (indole-3-yl)acetonitrile, and also on some aliphatic nitriles, and on the corresponding acid amides.; Function: for instance in plants the auxin indole-3-acetic acid is synthesized from indole-3-acetonitrile by nitrilase, after indole-3-acetonitrile is formed from tryptophan via indole-3-acetaldoxime or indole glycosinolates as the intermediate.; Function: the enzyme acts in a wide range of pathways, like tryptophan metabolism, cyanoamino acid metabolism and nitrogen metabolism.; Title: strong similarity to nitrilase - Alcaligenes faecalis; See PMID 8419930; See PMID 2269298; uncharacterized protein 1366825 4989013 An16g06210 Aspergillus niger uncharacterized protein XP_001397925.3 1365647 R 5061 CDS An16g06220 4989014 join(1367108..1367254,1367322..1367436,1367491..1368562,1368621..1368918) V 1 NT_166531.1 Function: Lac12 from K. lactis mediates the transport of lactose and it seems that the permease works in part by a proton symport mechanism.; Similarity: the predicted protein has much stronger similarity to the putative hexose transporter htxA of Aspergillus parasiticus.; Title: strong similarity to lactose permease Lac12 -Kluyveromyces lactis; plasma membrane; See PMID 3053697; See PMID 10978525; uncharacterized protein 1368918 4989014 An16g06220 Aspergillus niger uncharacterized protein XP_001397926.3 1367108 D 5061 CDS An16g06230 84593465 join(1369967..1370070,1370115..1370140,1370195..1370310,1370375..1370459,1370505..1370557) V 1 NT_166531.1 hypothetical protein 1370557 84593465 An16g06230 Aspergillus niger hypothetical protein XP_059604853.1 1369967 D 5061 CDS An16g06240 4989016 1371026..1372060 V 1 NT_166531.1 Function: PsADH1 disruption results in a lower growth rate and profoundly greater accumulation of xylitol,therefore PsADH1 likely plays a role in xylose fermentation.; Function: PsADH1 has the ability to convert ethanol to acetaldehyde.; Similarity: the predicted A. niger protein shows similarity to several hypothetical alcohol dehydrogenases and NADPH:quinone oxidoreductases.; Title: similarity to alcohol dehydrogenase PsADH1 -Pichia stipitis; See PMID 9546172; uncharacterized protein 1372060 4989016 An16g06240 Aspergillus niger uncharacterized protein XP_001397928.1 1371026 D 5061 CDS An16g06250 84593466 complement(1373331..1374992) V 1 NT_166531.1 Title: similarity to hypothetical protein encoded by An04g09840 - Aspergillus niger; uncharacterized protein 1374992 84593466 An16g06250 Aspergillus niger uncharacterized protein XP_059604854.1 1373331 R 5061 CDS An16g06260 4989018 complement(join(1375531..1376174,1376217..1376587,1376656..1376849,1376992..1377120,1377179..1377244)) V 1 NT_166531.1 Title: weak similarity to alkaline serine protease ispQ - Bacillus sp.; uncharacterized protein 1377244 4989018 An16g06260 Aspergillus niger uncharacterized protein XP_059604855.1 1375531 R 5061 CDS An16g06270 4989019 1378003..1378740 V 1 NT_166531.1 Function: A. nidulans verA is a carbonyl reductase which converts the aflatoxin (AF) precursor versicolorin A to sterigmatocystin (ST).; Pathway: A. nidulans verA is involved in the sterigmatocystin synthesis pathway.; Remark: an alternative name for A. nidulans verA is stcU.; Title: similarity to versicolorin reductase verA -Aspergillus nidulans; See PMID 7486998; See PMID 8017929; See PMID 9895285; uncharacterized protein 1378740 4989019 An16g06270 Aspergillus niger uncharacterized protein XP_001397931.1 1378003 D 5061 CDS An16g06290 84593467 complement(join(1379916..1380054,1380329..1380515,1380597..1380636)) V 1 NT_166531.1 Remark: blastp with the predicted A. niger protein only retrieves random hits to threonine and proline rich proteins.; hypothetical protein 1380636 84593467 An16g06290 Aspergillus niger hypothetical protein XP_059604856.1 1379916 R 5061 CDS An16g06300 4989022 complement(1380973..1382475) V 1 NT_166531.1 Function: S. cerevisiae FET4 is a low affinity Fe(II) and copper permease.; Title: strong similarity to Fe(II) permease Fet4 -Saccharomyces cerevisiae; plasma membrane; See PMID 7929320; See PMID 11023834; uncharacterized protein 1382475 4989022 An16g06300 Aspergillus niger uncharacterized protein XP_001397933.1 1380973 R 5061 CDS An16g06330 84593468 complement(join(1386142..1386553,1386641..1386672)) V 1 NT_166531.1 Remark: blastp with the predicted A. niger protein only retrieves random hits to proline and threonine rich proteins.; hypothetical protein 1386672 84593468 An16g06330 Aspergillus niger hypothetical protein XP_059604857.1 1386142 R 5061 CDS An16g06340 84593469 join(1387655..1387726,1387924..1387988,1388120..1388315,1388445..1388507) V 1 NT_166531.1 hypothetical protein 1388507 84593469 An16g06340 Aspergillus niger hypothetical protein XP_059604858.1 1387655 D 5061 CDS An16g06350 4989027 complement(join(1390998..1392429,1392484..1392671)) V 1 NT_166531.1 Catalytic activity: delta(6)-desaturass convert linoleoyl-CoA + AH(2) + O(2) to gamma-linolenoyl-CoA + A + 2 H(2)O.; Function: M. rouxii delta(6)-desaturase transforms linoleic acid into Gamma-linolenic acid (GLA) an essential fatty acid.; Title: strong similarity to delta(6)-desaturase -Mucor rouxii; See PMID 11112411; uncharacterized protein 1392671 4989027 An16g06350 Aspergillus niger uncharacterized protein XP_001397937.3 1390998 R 5061 CDS An16g06360 4989028 complement(join(1393430..1393520,1393724..1394000,1394069..1394701,1394752..1394878,1394933..1395216,1395347..1395386)) V 1 NT_166531.1 Function: A. flavus omtB converts demethylsterigmatocystin to sterigmatocystin and dihydrodemethylsterigmatocystin to dihydrosterigmatocystin by transfering a methyl group from donor SAM.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Remark: the A. flavus homologue 'O-methyltransferase B' belongs to the aflatoxin biosynthetic gene cluster.; Title: strong similarity to O-methyltransferase omtB - Aspergillus flavus; See PMID 6798444; See PMID 10806361; uncharacterized protein 1395386 4989028 An16g06360 Aspergillus niger uncharacterized protein XP_059604859.1 1393430 R 5061 CDS An16g06370 4989029 complement(join(1396105..1396133,1396215..1396283,1396331..1396427,1396595..1396618,1396723..1396885,1396943..1397109,1397168..1397278,1397344..1398218,1398277..1398475)) V 1 NT_166531.1 Pathway: TRI4 of Fusarium sporotrichioides catalyzes the first oxygenation step in the trichothecene pathway and participates in apotrichodiol biosynthesis.; Remark: trichothecenes are sesquiterpenoid mycotoxins and act as protein synthesis inhibitors for eukaryotic organisms.; Similarity: F. sporotrichioides TRI4 belongs to the cytochrome P450 family CYP58.; Title: strong similarity to cytochrome P450 trichodiene oxygenase TRI4 - Fusarium sporotrichioides; uncharacterized protein 1398475 4989029 An16g06370 Aspergillus niger uncharacterized protein XP_059604860.1 1396105 R 5061 CDS An16g06380 84593470 join(1400280..1400762,1400865..1400892,1401024..1401061,1401152..1401355) V 1 NT_166531.1 Similarity: similarity is between the N-terminal regions of the predicted A. niger protein and human SRPK1,which is 400 aa longer.; Similarity: the predicted A. niger protein contains a N-terminal serine/threonine protein kinase domain and shows similarity to serine/threonine protein kinases, most of them SR-family splicing factor specific.; Title: similarity to SR-family splicing factor specific serine/threonine kinase SRPK1 - Homo sapiens; deleted EC_number 2.7.1.37; See PMID 9472028; uncharacterized protein 1401355 84593470 An16g06380 Aspergillus niger uncharacterized protein XP_059604861.1 1400280 D 5061 CDS An16g06390 4989031 join(1403908..1404522,1404575..1405377,1405475..1406753) V 1 NT_166531.1 Title: strong similarity to hypothetical protein SPAC2C4.17c - Schizosaccharomyces pombe; uncharacterized protein 1406753 4989031 An16g06390 Aspergillus niger uncharacterized protein XP_059604862.1 1403908 D 5061 CDS An16g06400 4989032 complement(join(1406976..1407246,1407333..1407859)) V 1 NT_166531.1 Function: S. cerevisiae Mgm101p binds to DNA and likely is involved in the repair of oxidatively damaged mtDNA.; Function: S. cerevisiae mgm101 cells were more sensitive to mtDNA damage induced by UV irradiation, gamma rays and H2O2 treatment, while mtDNA packaging, segregation, partitioning or replication were not affected.; Function: the S. cerevisiae (nuclear) mutation mgm101 results in temperature sensitive loss of mitochondrial DNA (mtDNA).; Localization: subcellular fractionation, indirect immunofluorescence and GFP tagging show that S. cerevisiae Mgm101p is exclusively associated with the mitochondrial nucleoid structure in cells.; Title: strong similarity to mtDNA repair protein Mgm101 - Saccharomyces cerevisiae; See PMID 8346025; See PMID 10209025; uncharacterized protein 1407859 4989032 An16g06400 Aspergillus niger uncharacterized protein XP_001397942.1 1406976 R 5061 CDS An16g06410 4989033 join(1408559..1408682,1408725..1409361,1409424..1409987,1410037..1410308,1410371..1410870) V 1 NT_166531.1 Function: S. cerevisiae bpl1 mutants are lethal due to the lack of malonyl-CoA-dependent very-long-chain-fatty-acid (VLCFA) synthesis.; Function: biotinylation by S. cerevisiae BPL1 is essential for the assembly of acetyl-CoA-carboxylase (ACC) holoenzyme and in addition affects pyruvate carboxylase and other biotin-containing proteins.; Remark: alternative names for S. cerevisiae BPL1 are ACC2 and YDL141w.; Title: strong similarity to biotin-apoprotein ligase Bpl1 - Saccharomyces cerevisiae; See PMID 7649444; See PMID 9688262; uncharacterized protein 1410870 4989033 An16g06410 Aspergillus niger uncharacterized protein XP_059604863.1 1408559 D 5061 CDS An16g06420 4989034 join(1412051..1412446,1412506..1413629,1414007..>1414087) V 1 NT_166531.1 Function: n-alkane-inducible cytochrome P450s catalyze terminal hydroxylation of n-alkanes in the assimilation pathway.; Remark: n-alkane-inducible cytochrome P450s form a multigene family in n-alkane utilising yeast, and show overlapping substrate specifity concerning chain lenght.; Title: strong similarity to n-alkane-inducible cytochrome P450 protein ALK1 - Yarrowia lipolytica [putative frameshift]; putative frameshift; See PMID 9848230; uncharacterized protein 1414087 4989034 An16g06420 Aspergillus niger uncharacterized protein XP_001397944.3 1412051 D 5061 CDS An16g06430 84593471 complement(join(1414479..1414632,1414673..1414740)) V 1 NT_166531.1 Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1414740 84593471 An16g06430 Aspergillus niger uncharacterized protein XP_059604864.1 1414479 R 5061 CDS An16g06440 4989036 join(1415439..1415548,1415677..1415765,1415819..1416163,1416217..1416341,1416393..1416629,1416681..1416815,1416875..1416972,1417033..1417205,1417313..1417741,1417819..1418069) V 1 NT_166531.1 Function: the AmdA transcriptional activator from A. nidulans is involved in the induction of the E. nidulans structual gene amdS (acetamidase).; Title: similarity to zinc-finger transcription factor amdA - Aspergillus nidulans; nucleus; See PMID 7596297; See PMID 9126617; uncharacterized protein 1418069 4989036 An16g06440 Aspergillus niger uncharacterized protein XP_059604865.1 1415439 D 5061 CDS An16g06450 84593472 join(1418618..1418980,1419062..1419439) V 1 NT_166531.1 Function: C. lunatus 17beta-HSDcl catalyses the reduction of steroids and of several o- and p-quinones.; Title: strong similarity to 17beta-hydroxysteroid dehydrogenase 17beta-HSDcl - Cochliobolus lunatus; See PMID 9895285; uncharacterized protein 1419439 84593472 An16g06450 Aspergillus niger uncharacterized protein XP_059604866.1 1418618 D 5061 CDS An16g06460 4989038 join(1420072..1420281,1420353..1420405,1420509..1420708,1420775..1421568) V 1 NT_166531.1 Title: weak similarity to trithorax homologue 2 MLL2 - Homo sapiens; See PMID 10409430; uncharacterized protein 1421568 4989038 An16g06460 Aspergillus niger uncharacterized protein XP_059604867.1 1420072 D 5061 CDS An16g06470 4989039 join(1422834..1422879,1422970..1423141,1423221..1423338,1423401..1423486,1423540..1423623,1423744..1423861,1423933..1424067) V 1 NT_166531.1 Function: S. cerevisiae Ayr1p catalyses the NADPH-dependent reduction of the intermediate 1-acyldihydroxyacetone phosphate.; Function: S. cerevisiae Ayr1p is involved in the biosynthesis of phosphatidic acid through the dihydroxyacetone phosphate pathway.; Function: S. cerevisiae spores bearing the ayr1 defect failed to germinate.; Localization: S. cerevisiae Ayr1p localises to lipid particles and endoplasmic reticulum.; Remark: the systematic name for S. cerevisiae AYR1 is YIL124w.; Title: similarity to 1-acyldihydroxyacetone-phosphate reductase Ayr1 -Saccharomyces cerevisiae; See PMID 10617610; uncharacterized protein 1424067 4989039 An16g06470 Aspergillus niger uncharacterized protein XP_059604868.1 1422834 D 5061 CDS An16g06480 4989040 complement(1425164..1426090) V 1 NT_166531.1 Similarity: the predicted A. niger protein contains an epimerase/dehydratase motif.; Title: similarity to hypothetical protein encoded by slr0317 - Synechocystis sp.; uncharacterized protein 1426090 4989040 An16g06480 Aspergillus niger uncharacterized protein XP_001397950.1 1425164 R 5061 CDS An16g06490 4989041 complement(join(1427119..1427674,1427746..1427960)) V 1 NT_166531.1 Similarity: the predicted A. niger protein contains a dienelactone hydrolase motif.; Title: similarity to glucanase ZmGnsN4 from patent WO200073470-A2 - Zea mays; uncharacterized protein 1427960 4989041 An16g06490 Aspergillus niger uncharacterized protein XP_001397951.1 1427119 R 5061 CDS An16g06500 4989042 join(1428622..1428934,1428971..1429587,1429649..1429975) V 1 NT_166531.1 Function: C. testosteroni mhpA is involved in the degradation of 3-(3-hydroxyphenyl)propionate (3HPP) via the meta pathway.; Similarity: similarity is from the predicted A. niger protein to the N-terminal 2/3s of C. testosteroni mhpA, which is 160 aa longer.; Title: similarity to 3-(3-hydroxyphenyl)propionate hydroxylase mhpA - Comamonas testosteroni; See PMID 10537203; uncharacterized protein 1429975 4989042 An16g06500 Aspergillus niger uncharacterized protein XP_059604869.1 1428622 D 5061 CDS An16g06510 4989043 join(1431948..1432760,1432853..1432982,1433087..1433148) V 1 NT_166531.1 Similarity: the predicted A. niger protein shows similarity to several predicted methyltransferases and contains a strong methyltransferase motif.; Title: similarity to protein involved in biotin biosynthetis BioC - Kurthia sp.; See PMID 11255013; uncharacterized protein 1433148 4989043 An16g06510 Aspergillus niger uncharacterized protein XP_001397953.3 1431948 D 5061 CDS An16g06520 4989044 join(1433796..1433882,1433941..1434014,1434073..1434132,1434196..1434298) V 1 NT_166531.1 hypothetical protein 1434298 4989044 An16g06520 Aspergillus niger hypothetical protein XP_001397954.1 1433796 D 5061 CDS An16g06530 4989045 complement(join(1435368..1436290,1436351..1436804,1436854..1437864,1437929..1438063)) V 1 NT_166531.1 Function: C. lagenarium cmr1Delta mutants do not express the melanin biosynthetic structural genes SCD1 and THR1 during mycelial melanization although the expression of these two genes was not affected during appressorial melanization.; Similarity: C. lagenarium CMR1 is unique in that it contains two distinct DNA-binding motifs, a Cys2His2 zinc finger motif and a Zn(II)2Cys6 binuclear cluster motif.; Title: similarity to transcription activator CMR1 -Colletotrichum lagenarium; nucleus; See PMID 11123670; uncharacterized protein 1438063 4989045 An16g06530 Aspergillus niger uncharacterized protein XP_059604870.1 1435368 R 5061 CDS An16g06540 4989046 complement(1438354..1439427) V 1 NT_166531.1 Function: guinea pig zeta-crystallin has been characterized as an NADPH:quinone oxidoreductase (EC 1. 6. 5. 5), while bovine CRYZ shows minimal quinone oxidoreductase activity but strong binding affinity to single-stranded DNA (ssDNA) that could be competed with NADPH.; Similarity: the predicted A. niger protein shows similarity to several predicted zinc-binding oxidoreductases.; Title: similarity to zeta-crystallin CRYZ - Bos taurus; See PMID 9154917; uncharacterized protein 1439427 4989046 An16g06540 Aspergillus niger uncharacterized protein XP_001397956.1 1438354 R 5061 CDS An16g06550 4989047 join(1439910..1440037,1440099..1440744,1440804..1440839) V 1 NT_166531.1 Title: weak similarity to hypothetical mitomycin biosynthetic cluster protein MmcO - Streptomyces lavendulae; See PMID 10099135; uncharacterized protein 1440839 4989047 An16g06550 Aspergillus niger uncharacterized protein XP_001397957.1 1439910 D 5061 CDS An16g06560 4989048 complement(join(1441205..1442481,1442546..1442669,1442728..1443030)) V 1 NT_166531.1 Catalytic activity: glutaryl 7-ACA acylase converts 7 beta-(4-carboxybutanamido)cephalosporanic acid (glutaryl 7-ACA) to 7-amino cephalosporanic acid (7-ACA).; Function: glutaryl 7-ACA acylase is one of the two enzymes involved in the biotransformation of cephalosporin C (CefC) into 7-aminocephalosporanic acid (7-ACA).; Remark: 7-aminocephalosporanic acid (7-ACA) is the primary substrate for the industrial synthesis of semisynthetic cephalosporins as beta-lactam antibiotics.; Title: similarity to glutaryl 7-ACA acylase -Bacillus laterosporus; See PMID 8181946; See PMID 11080627; See PMID 1744041; uncharacterized protein 1443030 4989048 An16g06560 Aspergillus niger uncharacterized protein XP_001397958.1 1441205 R 5061 CDS An16g06570 84593473 complement(join(1443641..1443821,1443944..1443976,1444046..1444086,1444162..1444284)) V 1 NT_166531.1 Remark: blastp with the predicted A. niger protein only retrieves random hits to alanine rich proteins.; hypothetical protein 1444284 84593473 An16g06570 Aspergillus niger hypothetical protein XP_059604871.1 1443641 R 5061 CDS An16g06580 4989050 complement(join(1447814..1448020,1448065..1448486,1448548..1448944,1449011..1449496)) V 1 NT_166531.1 Function: A. nidulans QUTD encodes an essential component of a permease required for transport of quinate ion into mycelium at pH 6. 5.; Function: mutations in the qutD gene of A. nidulans cause the loss of ability to grow upon quinic acid as sole carbon source in media at pH 6. 5 and failure to induce three enzyme activities specifically required for metabolism to protochatechuic acid.; Title: strong similarity to quinate transport protein qutD - Aspergillus nidulans; See PMID 2835177; See PMID 2976880; uncharacterized protein 1449496 4989050 An16g06580 Aspergillus niger uncharacterized protein XP_059604872.1 1447814 R 5061 CDS An16g06590 4989051 join(1450238..1450307,1450416..1450898,1451090..1451727) V 1 NT_166531.1 Function: A. aculeatus beta-1,4-galactanase degrades unsubstituted galactan to galactose and galactobiose.; Remark: the A. niger protein could have been predicted with a 1. Exon that is nearly identical to the 1. Exon of A. aculeatus beta-1,4-galactanase, but contains several stop codons. Instead of modeling the A. niger protein as a pseudogene it was modeled with a new 1. Exon.; Title: strong similarity to beta-1,4-galactanase -Aspergillus aculeatus [putative pseudogene]; extracellular/secretion proteins; See PMID 7788716; uncharacterized protein 1451727 4989051 An16g06590 Aspergillus niger uncharacterized protein XP_059604873.1 1450238 D 5061 CDS An16g06600 4989052 join(1453845..1454058,1454115..1454233,1454292..1454957) V 1 NT_166531.1 Title: weak similarity to beta-galactosidase -Planococcus sp.; See PMID 10831422; uncharacterized protein 1454957 4989052 An16g06600 Aspergillus niger uncharacterized protein XP_001397962.1 1453845 D 5061 CDS An16g06610 4989053 complement(join(1455760..1455907,1455980..1456880,1456950..1457005,1457062..1457390)) V 1 NT_166531.1 Function: in K. lactis disruption of hgt1 confered much-reduced uptake of glucose at low concentrations and growth was particularly affected in low-glucose medium.; Regulation: in K. lactis expression of HGT1 is constitutive.; Title: strong similarity to high-affinity glucose transporter HGT1 - Kluyveromyces lactis; plasma membrane; See PMID 8830679; uncharacterized protein 1457390 4989053 An16g06610 Aspergillus niger uncharacterized protein XP_059604874.1 1455760 R 5061 CDS An16g06620 4989054 complement(1457846..1459135) V 1 NT_166531.1 Function: F. oxysporum lactonohydrolase hydrolyses aldonate lactones to the corresponding aldonic acids.; Title: strong similarity to lactonohydrolase from patent WO200028043-A2 - Fusarium venenatum; See PMID 9788992; uncharacterized protein 1459135 4989054 An16g06620 Aspergillus niger uncharacterized protein XP_059604875.1 1457846 R 5061 CDS An16g06630 4989055 join(1459955..1459988,1460063..1460407,1460461..1460918) V 1 NT_166531.1 Catalytic activity: C. testosteroni bphB converts cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) to biphenyl-2,3-diol + NADH.; Function: C. testosteroni bphB catalyzes the second step in the biphenyl degradation pathway.; Remark: EC 1. 3. 1. 56 (net in EC number cat yet).; Title: similarity to 2,3-dihydro-2,3-dihydroxybiphenyl-2,3-dehydrogenase bphB - Comamonas testosteroni; See PMID 8702262; uncharacterized protein 1460918 4989055 An16g06630 Aspergillus niger uncharacterized protein XP_001397965.1 1459955 D 5061 CDS An16g06640 84593474 complement(join(1461748..1463897,1464030..1464189)) V 1 NT_166531.1 Function: A. nidulans facB is a major regulatory gene involved in acetamide and acetate utilisation and is required for growth on acetate as a sole carbon source.; Similarity: similarity is between the N-terminal halfs of the predicted A. niger protein and A. niger facB,which contain the Gal4-type Zn(2)-Cys(6) DNA-binding domain.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus niger; See PMID 9197408; uncharacterized protein 1464189 84593474 An16g06640 Aspergillus niger uncharacterized protein XP_059604876.1 1461748 R 5061 CDS An16g06650 84593475 join(1465130..1465889,1466011..1467803) V 1 NT_166531.1 Similarity: the predicted A. niger protein contains a fungal Gal4 type Zn(2)-Cys(6) DNA-binding motif.; Title: weak similarity to zinc-finger protein zas1p - Schizosaccharomyces pombe; nucleus; See PMID 10718196; uncharacterized protein 1467803 84593475 An16g06650 Aspergillus niger uncharacterized protein XP_059604877.1 1465130 D 5061 CDS An16g06660 84593476 join(1469638..1470010,1470063..1470259,1470334..1470447) V 1 NT_166531.1 Title: weak similarity to constituent of COPII coats Sfb2 - Saccharomyces cerevisiae; See PMID 10749860; uncharacterized protein 1470447 84593476 An16g06660 Aspergillus niger uncharacterized protein XP_059604878.1 1469638 D 5061 CDS An16g06670 84593477 complement(1472108..1472854) V 1 NT_166531.1 Title: weak similarity to hypothetical protein CAC10504.1 - Pseudonocardia sp.; uncharacterized protein 1472854 84593477 An16g06670 Aspergillus niger uncharacterized protein XP_059604879.1 1472108 R 5061 CDS An16g06680 4989060 join(1474312..1475520,1475631..1475670,1475840..1475871,1475906..1475911) V 1 NT_166531.1 Title: weak similarity to hypothetical protein VC2566 - Vibrio cholerae; uncharacterized protein 1475911 4989060 An16g06680 Aspergillus niger uncharacterized protein XP_001397970.3 1474312 D 5061 CDS An16g06690 4989061 complement(join(1476998..1477107,1477266..1478422,1478506..1479005)) V 1 NT_166531.1 Title: similarity to hypothetical protein CG12065 -Drosophila melanogaster; uncharacterized protein 1479005 4989061 An16g06690 Aspergillus niger uncharacterized protein XP_059604880.1 1476998 R 5061 CDS An16g06700 4989063 join(1479845..1480223,1480275..1480480) V 1 NT_166531.1 hypothetical protein 1480480 4989063 An16g06700 Aspergillus niger hypothetical protein XP_059604881.1 1479845 D 5061 CDS An16g06710 84593478 join(1480578..1483367,1483507..1483530,1483922..1484037,1484241..1484310,1484578..1484820,1484852..1485132,1485297..1485331,1485368..1485441,1485597..1485722) V 1 NT_166531.1 Function: ankyrins link the spectrin-based membrane skeleton to the plasma membrane.; Title: similarity to ankyrin 1 - Mus musculus; cytoskeleton; See PMID 8486643; uncharacterized protein 1485722 84593478 An16g06710 Aspergillus niger uncharacterized protein XP_059604882.1 1480578 D 5061 CDS An16g06720 10098073 complement(join(1486581..1490381,1490436..1498367,1498459..1498608,1498660..1507884)) V 1 NT_166531.1 Function: C. carbonum HTS is a multifunctional peptide synthase, able to activate the amino acids pro,l-ala, d-ala and aeo (2-amino-9,10- epoxi-8-oxodecanioc acid), and epimerize pro and l-ala.; Title: strong similarity to HC-toxin peptide synthase HTS - Cochliobolus carbonum; See PMID 1281482; uncharacterized protein 1507884 10098073 An16g06720 Aspergillus niger uncharacterized protein XP_059604883.1 1486581 R 5061 CDS An16g06730 84593479 join(1509116..1509142,1509430..1509492,1509544..1509557,1509718..1509883) V 1 NT_166531.1 Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1509883 84593479 An16g06730 Aspergillus niger uncharacterized protein XP_059604884.1 1509116 D 5061 CDS An16g06740 4989066 join(<1511800..1511998,1512052..1512278,1512335..1512614,1512675..1512908,1512966..1514424,1514491..1515913) V 1 NT_166531.1 Remark: YCF1 of S. cerevisiae is required for cadmium resistance.; Remark: the ORF is N-terminally truncated due to contig border.; Similarity: YCF1 of S. cerevisiae belongs to superfamily of human multidrug resistance protein cMOAT2.; Similarity: similar to ATP-binding cassette transporters.; Title: strong similarity to cadmium resistance protein Ycf1 - Saccharomyces cerevisiae [truncated ORF]; See PMID 7521334; uncharacterized protein 1515913 4989066 An16g06740 Aspergillus niger uncharacterized protein XP_001397976.3 1511800 D 5061 CDS An16g06750 4989067 join(1516565..1516932,1516993..1518268) V 1 NT_166531.1 Catalytic activity: D-amino acid amides and methyl esters also are hydrolysed, as is glycine amide.; Catalytic activity: Release of an N-terminal D-amino acid from a peptide, Xaa-|-Xaa-, in which Xaa is preferably D-Ala, D-Ser or D-Thr.; Similarity: also similar to several beta-lactamases.; Title: similarity to D-stereospecific aminopeptidase - Ochrobactrum anthropi; See PMID 2760064; uncharacterized protein 1518268 4989067 An16g06750 Aspergillus niger uncharacterized protein XP_001397977.1 1516565 D 5061 CDS An16g06760 4989068 complement(join(1519710..1520164,1520221..1520467)) V 1 NT_166531.1 Function: Overexpression of RTM1 in yeast confers resistance to the toxicity of molasses.; Similarity: Also similar to 7-aminocholesterol resistance protein RTA1 of S. cerevisiae.; Title: strong similarity to molasses resistency protein Rtm1 - Saccharomyces cerevisiae; See PMID 7672593; uncharacterized protein 1520467 4989068 An16g06760 Aspergillus niger uncharacterized protein XP_001397978.1 1519710 R 5061 CDS An16g06770 4989069 join(1522569..1522824,1522923..1523029,1523085..1523668,1523721..1524150) V 1 NT_166531.1 Function: TAT1 of R. norvegicus facilitates Na+ -independent and low-affinity transport of aromatic amino acids such as tryptophan, tyrosine, and phenylalanine.; Similarity: also similar to H+/monocarboxylate transporters.; Title: strong similarity to T-type amino acid transporter 1 TAT1 - Rattus norvegicus; See PMID 11278508; uncharacterized protein 1524150 4989069 An16g06770 Aspergillus niger uncharacterized protein XP_001397979.1 1522569 D 5061 CDS An16g06780 4989070 complement(join(1524247..1525335,1525397..1526310,1526425..1526473)) V 1 NT_166531.1 Function: CHA4 of S. cerevisiae activates CHA1 by binding to UAS1(CHA) and UAS2(CHA) elements in the CHA1 promoter.; Remark: CHA4 of S. cerevisiae belongs to unassigned GAL4-type zinc cluster proteins.; Title: similarity to transcription activator Cha4 -Saccharomyces cerevisiae; uncharacterized protein 1526473 4989070 An16g06780 Aspergillus niger uncharacterized protein XP_001397980.3 1524247 R 5061 CDS An16g06790 4989071 complement(1526777..1528135) V 1 NT_166531.1 Title: similarity to hypothetical protein Rv0272c -Mycobacterium tuberculosis; uncharacterized protein 1528135 4989071 An16g06790 Aspergillus niger uncharacterized protein XP_001397981.1 1526777 R 5061 CDS An16g06800 4989072 complement(join(1530161..1530304,1530608..1531245,1531300..1531397,1531453..1531517,1531578..1531786,1531835..1531931)) V 1 NT_166531.1 Catalytic activity: eglB of A. niger catalyzes the endohydrolysis of 1,4-beta-d-glucosidic linkages in cellulose.; Function: eglB of A. niger has carboxylmethylcellulase activity.; Similarity: eglB of A. niger belongs to cellulase family h (family 12 of glycosyl hydrolases).; Title: strong similarity to endoglucanase eglB -Aspergillus niger; See PMID 9758775; uncharacterized protein 1531931 4989072 An16g06800 Aspergillus niger uncharacterized protein XP_059602773.1 1530161 R 5061 CDS An16g06810 4989073 complement(join(1533575..1534507,1534566..1534631)) V 1 NT_166531.1 Title: strong similarity to hypothetical protein YGR127w - Saccharomyces cerevisiae; uncharacterized protein 1534631 4989073 An16g06810 Aspergillus niger uncharacterized protein XP_059602774.1 1533575 R 5061 CDS An16g06820 4989074 join(1535887..1535915,1536047..1536196,1536257..1537049) V 1 NT_166531.1 Title: strong similarity to hypothetical pathogenicity protein PATH531 - Magnaporthe grisea; uncharacterized protein 1537049 4989074 An16g06820 Aspergillus niger uncharacterized protein XP_001397984.1 1535887 D 5061 CDS An16g06830 84593480 join(1537421..1537829,1537948..1538252) V 1 NT_166531.1 hypothetical protein 1538252 84593480 An16g06830 Aspergillus niger hypothetical protein XP_059602775.1 1537421 D 5061 CDS An16g06840 84593481 1540403..1541179 V 1 NT_166531.1 Similarity: similarity only to repetetive sequences.; hypothetical protein 1541179 84593481 An16g06840 Aspergillus niger hypothetical protein XP_059602776.1 1540403 D 5061 CDS An16g06850 4989077 join(1541320..1544661,1544721..1544804,1544864..1545240,1545295..1545439) V 1 NT_166531.1 Function: eIF-4F of S. cerevisiae is a 150K subunit of a mRNA cap-binding protein.; Remark: In S. cereviae TIF4631 is probably essential when TIF4632 is missing.; Similarity: similarity to mammalian translation initiation factor eIF-4 gamma.; Title: strong similarity to translation initiation factor eIF-4F Tif4631 - Saccharomyces cerevisiae; uncharacterized protein 1545439 4989077 An16g06850 Aspergillus niger uncharacterized protein XP_001397987.3 1541320 D 5061 CDS An16g06860 4989078 complement(join(<1547091..1547606,1547666..1547919)) V 1 NT_166531.1 Remark: C-terminally truncated ORF due to contig border.; Title: strong similarity to hypothetical protein SPBC25B2.10 - Schizosaccharomyces pombe [truncated ORF]; uncharacterized protein 1547919 4989078 An16g06860 Aspergillus niger uncharacterized protein XP_001397988.3 1547091 R 5061 CDS An16g06870 84593482 join(1547930..1547981,1548086..1548193,1548254..1548423,1548570..1548638) V 1 NT_166531.1 hypothetical protein 1548638 84593482 An16g06870 Aspergillus niger hypothetical protein XP_059604885.1 1547930 D 5061 CDS An16g06880 84593483 join(1549051..1549169,1549203..1549312,1549439..1549530) V 1 NT_166531.1 hypothetical protein 1549530 84593483 An16g06880 Aspergillus niger hypothetical protein XP_059604886.1 1549051 D 5061 CDS An16g06890 4989081 complement(1550070..1550915) V 1 NT_166531.1 Similarity: the weak similarity to fibrinogen-binding protein of S. aureus is due to a dipeptide repeats region.; Title: weak similarity to fibrinogen-binding protein - Staphylococcus aureus; uncharacterized protein 1550915 4989081 An16g06890 Aspergillus niger uncharacterized protein XP_001397991.1 1550070 R 5061 CDS An16g06900 84593484 join(1551172..1551351,1551698..1551806,1552038..1552139,1552261..1552343) V 1 NT_166531.1 hypothetical protein 1552343 84593484 An16g06900 Aspergillus niger hypothetical protein XP_059604887.1 1551172 D 5061 CDS An16g06910 84593485 complement(join(1552476..1552558,1552697..1552858,1552953..1553057,1553163..1553243,1553663..1553725,1553834..1553903,1553999..1554112,1554195..1554245,1554513..1554572,1554745..1554781,1554876..1555015)) V 1 NT_166531.1 Title: questionable ORF; uncharacterized protein 1555015 84593485 An16g06910 Aspergillus niger uncharacterized protein XP_059604888.1 1552476 R 5061 CDS An16g06920 84593486 join(1555308..1555360,1555450..1555507,1555611..1555715) V 1 NT_166531.1 hypothetical protein 1555715 84593486 An16g06920 Aspergillus niger hypothetical protein XP_059604889.1 1555308 D 5061 CDS An16g06930 84593487 complement(join(1556011..1556079,1556135..1556301,1556361..1556478)) V 1 NT_166531.1 hypothetical protein 1556478 84593487 An16g06930 Aspergillus niger hypothetical protein XP_059604890.1 1556011 R 5061 CDS An16g06940 4989086 join(1557408..1557615,1557689..1557801,1557931..1557990,1558281..1559671,1559727..>1560410) V 1 NT_166531.1 Function: Trk1 of S. occidentalis is also involved in the control of the membrane potential.; Remark: putative frameshift due to possible sequencing error.; Similarity: the Trk proteins show significant similarity to the high affinity K+ transporter (HKT1p) from wheat roots which seems to act as a K+-Na+ co-transporter.; Similarity: the protein shows strong similarity to the TRK family of high affinity potassium transporters,represented in several fungal species.; Title: strong similarity to high-affinity potassium uptake transporter trk1 - Schwanniomyces occidentalis [putative frameshift]; plasma membrane; putative frameshift; See PMID 10931360; uncharacterized protein 1560410 4989086 An16g06940 Aspergillus niger uncharacterized protein XP_059604891.1 1557408 D 5061 CDS An16g06950 4989087 complement(join(1560680..1561002,1561065..1561413,1561461..1561639,1561701..1561831,1562031..1562587)) V 1 NT_166531.1 Function: JEN1 of S. cerevisiae is a lactate and pyruvate proton-driven symporter.; Induction: JEN1 of S. cerevisiae is induced by lactate.; Phenotype: Deletion of JEN1 in S. cerevisiae results in slow growth of yeast on synthetic medium supplemented with L-lactate.; Repression: JEN1 of S. cerevisiae is repressed by glucose.; Similarity: JEN1 of S. cerevisiae belongs to the sialate:H+ symporter (SHS) group of the major facilitator superfamily (MFS) of transport proteins.; Similarity: the protein shows a very strong similarity to a N. crassa gene, related to S. cerevisiae JEN1 as well.; Title: strong similarity to carboxylic acid transport protein Jen1 - Saccharomyces cerevisiae; plasma membrane; See PMID 10198029; uncharacterized protein 1562587 4989087 An16g06950 Aspergillus niger uncharacterized protein XP_001397997.1 1560680 R 5061 CDS An16g06960 84593488 join(1562723..1562919,1562981..1563144,1563314..1563546) V 1 NT_166531.1 hypothetical protein 1563546 84593488 An16g06960 Aspergillus niger hypothetical protein XP_059604892.1 1562723 D 5061 CDS An16g06980 84593489 complement(join(1564992..1565181,1565303..1565446,1565535..1565779,1565869..1565947,1566035..1566089,1566176..1566328,1566395..1566555,1566606..1566739)) V 1 NT_166531.1 Remark: ORF classified as questionable because on the opposite DNA strand, in the C terminal part of the encoded protein, there are promoter elements of the pgaA gene An16g06990.; Similarity: nucleotides 1-1161 of the predicted ORF are identical to the reverse complement of the promoter region of the pgaA gene of A. niger.; Title: questionable ORF; uncharacterized protein 1566739 84593489 An16g06980 Aspergillus niger uncharacterized protein XP_059604893.1 1564992 R 5061 CDS An16g06990 4989091 join(1566837..1567065,1567120..>1568004) V 1 NT_166531.1 Catalytic activity: random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans.; Function: degradation of the homogalacturonan part of the pectin molecule.; Gene-ID: pgaA;ppaS; Mapping: pgaA from A. niger is mapped to chromosome V; see EMBL Y18804.; Remark: a putative N-glycosidation site is located at Asn214 of the mature protein, and is strictly conserved in many characterized A. niger polygalacturonases.; Remark: a putative sequencing error results in an frameshift.; Remark: the enzyme is most likely synthesized as prepro-enzyme, and the signal peptide is probably cleaved at Ala19.; Similarity: pgaA belongs to the polygalacturonases (pga) gene family, consisting, in A. niger, of seven different genes.; extracellular/secretion proteins; putative frameshift; See PMID 1511691; See PMID 10642523; endo-polygalacturonase A pgaA-Aspergillus niger [putative frameshift] 1568004 pgaA 4989091 pgaA Aspergillus niger endo-polygalacturonase A pgaA-Aspergillus niger [putative frameshift] XP_059604894.1 1566837 D 5061 CDS An16g07010 84593490 complement(join(1568718..1568767,1568827..1569139,1569215..1569378,1569479..1569577,1569654..1569726,1569773..1569805)) V 1 NT_166531.1 hypothetical protein 1569805 84593490 An16g07010 Aspergillus niger hypothetical protein XP_059604895.1 1568718 R 5061 CDS An16g07020 84593491 join(1570869..1570878,1570910..1571637,1571699..1571786,1571855..1572190,1572247..1572338,1572447..1572851) V 1 NT_166531.1 Function: ArcA of A. nidulans might be involved in the regulation of arginine catabolic pathway (unpublished).; Title: similarity to transcription regulator of arginine catabolism arcA - Aspergillus nidulans; See PMID 62492; uncharacterized protein 1572851 84593491 An16g07020 Aspergillus niger uncharacterized protein XP_059604896.1 1570869 D 5061 CDS An16g07030 4989095 join(1574293..1574425,1574497..1574631,1574693..1574896,1574956..1575329,1575386..1575555,1575586..1575620,1575687..1575828,1575947..1575980) V 1 NT_166531.1 Catalytic activity: lovC of A. terreus probably acts as an enoyl reductase.; Function: lovC of A. terreus interacts with lovB in the biosynthesis of the lovastatin precursor dihydromonacolin L.; Remark: in A. terreus the genes involved in lovastatin biosynthesis are clustered.; Similarity: several putative dehydrogenases with possible different specificities show strong similarity to this protein.; Similarity: similarity to lovC of A. terreus is due to the zinc-binding dehydrogenase domain.; Title: similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994; uncharacterized protein 1575980 4989095 An16g07030 Aspergillus niger uncharacterized protein XP_001398003.3 1574293 D 5061 CDS An16g07040 4989096 complement(1577067..>1578338) V 1 NT_166531.1 Remark: N-terminally truncated ORF due to contig border; Similarity: BGT1 of A. fumigatus is similar to the glucan 1,3-beta-glucosidase BGL2 of S. cerevisiae.; Similarity: other similarities are due to repetitive Thr motifs.; Similarity: the protein shows much stronger similarity to several putative membrane proteins of S. cerevisiae.; Title: similarity to beta-1,3-glucanosyltransferase bgt1 - Aspergillus fumigatus [truncated ORF]; cell wall; See PMID 9846753; uncharacterized protein 1578338 4989096 An16g07040 Aspergillus niger uncharacterized protein XP_001398004.1 1577067 R 5061 CDS An16g07050 84593492 join(<1578464..1578760,1578846..>1578919) V 1 NT_166531.1 Title: weak similarity to hypothetical clone:C630039G13 - Mus musculus [truncated ORF]; uncharacterized protein 1578919 84593492 An16g07050 Aspergillus niger uncharacterized protein XP_059606771.1 1578464 D 5061 CDS An16g07060 84593493 join(1579458..1579528,1579750..1579825) V 1 NT_166531.1 Similarity: the predicted ORF shows a local weak similarity to a putative permease of Serpulina hyodysenteriae.; hypothetical protein 1579825 84593493 An16g07060 Aspergillus niger hypothetical protein XP_059606772.1 1579458 D 5061 CDS An16g07070 84593494 join(1579999..1580137,1580435..1580508,1580612..1580830) V 1 NT_166531.1 hypothetical protein 1580830 84593494 An16g07070 Aspergillus niger hypothetical protein XP_059606773.1 1579999 D 5061 CDS An16g07080 4989100 join(1581799..1581882,1581934..1582058,1582122..1582158) V 1 NT_166531.1 Similarity: the predicted ORF shows a very weak similarity to con-8 of N. crassa, a protein with unknown molecular function, which is expressed during conidiation.; hypothetical protein 1582158 4989100 An16g07080 Aspergillus niger hypothetical protein XP_001398008.1 1581799 D 5061 CDS An16g07090 4989101 complement(join(1582380..1582420,1582478..1582555,1582654..1583440)) V 1 NT_166531.1 Pathway: 3-oxoacyl-(acyl-carrier protein) reductases are involved in the fatty acids biosynthesis.; Remark: the patentmatch is against a protein entry,which represent the proteins encoded by all the open reading frames in the complete genome of C. pneumoniae.; Remark: the polypeptides encoded by the open reading frames of the C. pneumoniae genome can be used in immunogenic compositions as vaccines.; Similarity: protein sequence of patent WO9927105-A2 is almost identical to the putative 3-oxoacyl-(acyl-carrier protein) reductase CP0462 of C. pneumoniae.; Similarity: the predicted ORF shows similarity to the ribitol dehydrogenase superfamily, containing a short-chain alcohol dehydrogenase domain.; Title: similarity to transmembrane protein from patent WO9927105-A2 - Chlamydia pneumoniae; uncharacterized protein 1583440 4989101 An16g07090 Aspergillus niger uncharacterized protein XP_001398009.3 1582380 R 5061 CDS An16g07100 84593495 join(1583616..1583626,1583725..1583755,1583800..1584069) V 1 NT_166531.1 hypothetical protein 1584069 84593495 An16g07100 Aspergillus niger hypothetical protein XP_059606774.1 1583616 D 5061 CDS An16g07110 4989103 complement(join(1584579..1584806,1584857..1585822,1585876..1586116,1586182..1586324)) V 1 NT_166531.1 Catalytic activity: acetyl-CoA + H2O = CoA + acetate.; Function: the acetyl-CoA hydrolase is presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation.; Induction: ACH1 of S. cerevisiae is highly expressed during sporulation.; Repression: catalytic activity of ACH1 of S. cerevisiae is inhibited by Zn2+, and gene expression is repressed by glucose. .; Similarity: the predicted ORF shows local identities with several A. niger ESTs, e. g. : EMBLEST:BE759170.; Similarity: the predicted ORF shows strong similarity to the acetyl-CoA hydrolase of different species and to N. crassa acu-8.; Title: strong similarity to acetyl-CoA hydrolase Ach1 - Saccharomyces cerevisiae; See PMID 8841387; See PMID 1970569; See PMID 2570693; uncharacterized protein 1586324 4989103 An16g07110 Aspergillus niger uncharacterized protein XP_001398011.1 1584579 R 5061 CDS An16g07120 4989104 complement(join(1587841..1588470,1588526..1589764,1589820..1591160,1591223..1591320,1591546..1591922,1591972..1592797,1592889..1592933,1592994..1593033)) V 1 NT_166531.1 Complex: SIN3 of S. cerevisiae is part of a large multiprotein complex that includes the Rpd3 histone deacetylase.; Function: as part of the histone deacetylase complex, SIN3 of S. cerevisiae is required both for activation and repression of diverse genes, involved in a variety of important cellular processes.; Localization: SIN3 of S. cerevisiae is a nuclear protein, possibly linked to centromere.; Remark: SIN3 of S. cerevisiae is also known as rpd1,ume4, gam2, sdi1, YOL004W, CPE1, or SDS16.; Similarity: the predicted ORF contains three paired amphipathic helix repeats, domains which may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.; Title: strong similarity to regulator protein Sin3 -Saccharomyces cerevisiae; nucleus; See PMID 9651585; See PMID 10809695; See PMID 1944290; See PMID 2233725; uncharacterized protein 1593033 4989104 An16g07120 Aspergillus niger uncharacterized protein XP_059606775.1 1587841 R 5061 CDS An16g07130 4989105 complement(join(1594685..1594708,1594770..1595335,1595409..1596054,1596114..1596211,1596317..1596357,1596565..1596608)) V 1 NT_166531.1 Function: microscopic and genetic analyses indicate that rgb-1 is a regulator of the budding subroutine of the macroconidiation process and that arthroconidiation, which shares common early and late events with macroconidiation,is induced as a default mechanism for asexual reproduction in this fungus.; Remark: alternative splicing known for N. crassa protein.; Title: strong similarity to phosphatase 2A regulatory B subunit rgb-1 - Neurospora crassa; uncharacterized protein 1596608 4989105 An16g07130 Aspergillus niger uncharacterized protein XP_001398013.1 1594685 R 5061 CDS An16g07140 4989106 1598197..1599276 V 1 NT_166531.1 Similarity: similarity results from high content of repetitive sequences.; Title: weak similarity to hypothetical protein K06A9.1a - Caenorhabditis elegans; uncharacterized protein 1599276 4989106 An16g07140 Aspergillus niger uncharacterized protein XP_001398014.1 1598197 D 5061 CDS An16g07150 4989107 complement(join(1599714..1599799,1599867..1601323,1601388..1601625,1601713..1601781,1601848..1601887)) V 1 NT_166531.1 Cofactor: noncovalently bound FAD.; Function: FRDS1 of S. cerevisiae catalyzes the reduction of fumarate to succinate.; Similarity: shows stronger similarity to hypothetical enzymes of S. pombe and L. major.; Title: strong similarity to soluble cytoplasmic fumarate reductase YEL047c - Saccharomyces cerevisiae; cytoplasm; See PMID 8946166; See PMID 8953036; See PMID 9587404; uncharacterized protein 1601887 4989107 An16g07150 Aspergillus niger uncharacterized protein XP_001398015.1 1599714 R 5061 CDS An16g07160 84593496 complement(join(1602011..1602312,1602500..1602706,1602971..1603004,1603037..1603101,1603150..1603243)) V 1 NT_166531.1 hypothetical protein 1603243 84593496 An16g07160 Aspergillus niger hypothetical protein XP_059606776.1 1602011 R 5061 CDS An16g07170 84593497 complement(join(1604083..1604474,1604533..1604877,1604934..1605000,1605053..1605262,1605367..1605759,1605900..1605987,1606145..1606254,1606326..1606394,1606607..1606654)) V 1 NT_166531.1 Function: FUM5 is required for fumonisin biosynthesis.; Function: contains a domain typical for Zinc-binding dehydrogenases.; Remark: putative frameshift might be caused by sequencing error.; Similarity: shows only partial similarity to FUM5.; Title: similarity to polyketide synthase FUM5 -Gibberella moniliformis [putative frameshift]; putative frameshift; See PMID 10413619; uncharacterized protein 1606654 84593497 An16g07170 Aspergillus niger uncharacterized protein XP_059606777.1 1604083 R 5061 CDS An16g07180 4989110 complement(join(1607223..1607367,1607432..1607883,1607953..1608346,1608395..1608855)) V 1 NT_166531.1 Function: VDH is an enzyme for the synthesis of coniferyl alcohol, coniferyl aldehyde, ferulic acid,vanillin, vanillic acid and their applications.; Title: strong similarity to vanillin dehydrogenase VDH from patent EP0845532 - Unclassified organism; uncharacterized protein 1608855 4989110 An16g07180 Aspergillus niger uncharacterized protein XP_001398018.1 1607223 R 5061 CDS An16g07190 84593498 complement(join(1609538..1609797,1610036..1610191,1610307..1610419,1610535..1610681,1610855..1611223,1611302..1611378)) V 1 NT_166531.1 hypothetical protein 1611378 84593498 An16g07190 Aspergillus niger hypothetical protein XP_059606778.1 1609538 R 5061 CDS An16g07200 4989112 join(1611606..1611623,1611677..1612483) V 1 NT_166531.1 Function: the M. grisea PTH11 gene product is presumably involved in host surface recognition and can activate appressorium differentiation in response to inductive surface cues.; Similarity: shows only partial similarity to pth11p.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529; uncharacterized protein 1612483 4989112 An16g07200 Aspergillus niger uncharacterized protein XP_001398020.3 1611606 D 5061 CDS An16g07210 4989113 complement(1613107..1614369) V 1 NT_166531.1 Function: COP8 of A. thaliana is involved in photomorphogenesis.; Similarity: very high similarity to unpublished COP9 signalosome protein of A. nidulans.; Title: strong similarity to COP9 signalosome chain COP8 - Arabidopsis thaliana; uncharacterized protein 1614369 4989113 An16g07210 Aspergillus niger uncharacterized protein XP_001398021.3 1613107 R 5061 CDS An16g07220 4989114 join(1615166..1615465,1615547..1615811,1615864..1616060,1616123..1616512) V 1 NT_166531.1 Function: TFIIF is a general transcription initiation factor that binds to RNA polymerase II.; Title: strong similarity to beta subunit of transcription initiation factor TFIIF Tfg2 - Saccharomyces cerevisiae; nucleus; See PMID 9845373; uncharacterized protein 1616512 4989114 An16g07220 Aspergillus niger uncharacterized protein XP_001398022.1 1615166 D 5061 CDS An16g07230 4989115 join(1616934..1616979,1617031..1617603,1617655..1617766,1617819..1617874,1617981..1618552) V 1 NT_166531.1 Function: SIP2 contains an RNAase activity,providing a link between TGF-beta signal transduction and mRNA stabilisation.; Remark: SIP2 is from PatentDNA.; Similarity: shows only partial similarity to SIP2.; Similarity: shows similarity to several hypothetical proteins containing zinc-finger domains.; Title: similarity to SMAD interacting protein SIP2 from patent WO9855512-A2 - Mus musculus; uncharacterized protein 1618552 4989115 An16g07230 Aspergillus niger uncharacterized protein XP_001398023.1 1616934 D 5061 CDS An16g07240 84593499 complement(join(1622059..1622082,1622181..1622210,1622348..1622376,1622407..1622500,1622619..1622687)) V 1 NT_166531.1 hypothetical protein 1622687 84593499 An16g07240 Aspergillus niger hypothetical protein XP_059606779.1 1622059 R 5061 CDS An16g07250 84593500 join(1625011..1625160,1625358..1625486,1625587..1626045,1626354..1626377,1626433..1626450) V 1 NT_166531.1 Similarity: blast hits result from repetitive sequences.; Title: weak similarity to hypothetical protein CG14713 - Drosophila melanogaster; uncharacterized protein 1626450 84593500 An16g07250 Aspergillus niger uncharacterized protein XP_059606780.1 1625011 D 5061 CDS An16g07260 4989118 join(1628058..1628866,1628939..1630040) V 1 NT_166531.1 Function: the H. sapiens homolog E-MAP-115 is a microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_2321, 1979 and 1980.; Similarity: similarity is from a N-terminal laying region of the predicted A. niger protein to a C-terminal region of human E-MAP-115.; Similarity: the predicted A. niger protein contains a basic helix-loop-helix DNA binding motif.; Title: weak similarity to epithelial microtubule-associated protein E-MAP-115 - Homo sapiens; uncharacterized protein 1630040 4989118 An16g07260 Aspergillus niger uncharacterized protein XP_001398026.1 1628058 D 5061 CDS An16g07270 84593501 join(1636153..1636380,1636482..1636653,1636771..1636886) V 1 NT_166531.1 hypothetical protein 1636886 84593501 An16g07270 Aspergillus niger hypothetical protein XP_059606781.1 1636153 D 5061 CDS An16g07280 4989120 complement(join(1640657..1640687,1640971..1641035,1641215..1641521,1641632..1641725,1641787..1641826,1641878..1642682,1642786..1642940)) V 1 NT_166531.1 Function: S. pombe Nif1 inhibits mitosis by inhibiting Nim1-mediated phosphorylation and inhibition of Wee1, whose activity inhibits Cdc2/Cdc13 cyclin-dependent kinase.; Title: similarity to mitotic inhibitor nif1p -Schizosaccharomyces pombe; See PMID 9135149; uncharacterized protein 1642940 4989120 An16g07280 Aspergillus niger uncharacterized protein XP_001398028.3 1640657 R 5061 CDS An16g07290 4989121 complement(join(1643487..1643512,1643571..1643793,1643874..1644328,1644394..1644424)) V 1 NT_166531.1 Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_1922, an_1665 and an_2380.; Title: strong similarity to F1Fo-ATP synthase subunit 4 ATP4 - Kluyveromyces lactis; localisation:mitochondrion; See PMID 9790576; uncharacterized protein 1644424 4989121 An16g07290 Aspergillus niger uncharacterized protein XP_001398029.1 1643487 R 5061 CDS An16g07300 4989122 1644886..1646430 V 1 NT_166531.1 Title: strong similarity to polypeptide SEQ ID NO:5295 from patent WO200171042-A2 - Drosophila melanogaster; uncharacterized protein 1646430 4989122 An16g07300 Aspergillus niger uncharacterized protein XP_059606782.1 1644886 D 5061 CDS An16g07310 4989123 complement(1646720..1647643) V 1 NT_166531.1 hypothetical protein 1647643 4989123 An16g07310 Aspergillus niger hypothetical protein XP_001398031.1 1646720 R 5061 CDS An16g07320 84593502 join(1648098..1648270,1648317..1648602) V 1 NT_166531.1 Title: weak similarity to hypothetical transcriptional regulator CC1412 - Caulobacter crescentus; uncharacterized protein 1648602 84593502 An16g07320 Aspergillus niger uncharacterized protein XP_059606783.1 1648098 D 5061 CDS An16g07330 4989125 join(1649408..1649554,1649614..1650120) V 1 NT_166531.1 Title: weak similarity to hypothetical extracellular matrix protein AAL47843.1 - Fusarium oxysporum; uncharacterized protein 1650120 4989125 An16g07330 Aspergillus niger uncharacterized protein XP_001398033.1 1649408 D 5061 CDS An16g07340 4989126 join(1651852..1652068,1652139..1652977) V 1 NT_166531.1 Remark: alternative names for human CEP2 are CEP250 and centrosomal Nek2-associated protein 1 (C-NAP1).; Similarity: similarity is from the predicted A. niger protein to several regions of human CEP2, which is 2100 aa longer.; Title: weak similarity to Cdc42 effector CEP2 - Homo sapiens; See PMID 11035016; uncharacterized protein 1652977 4989126 An16g07340 Aspergillus niger uncharacterized protein XP_001398034.1 1651852 D 5061 CDS An16g07350 4989127 join(1654137..1654193,1654248..1654273,1654328..1654379,1654442..1654540,1654626..1654958,1655010..1658075) V 1 NT_166531.1 Remark: blastp with the predicted A. niger protein likely only retrieves random hits to serine rich proteins.; Title: weak similarity to gastric mucin - Sus scrofa; uncharacterized protein 1658075 4989127 An16g07350 Aspergillus niger uncharacterized protein XP_059606784.1 1654137 D 5061 CDS An16g07360 4989128 complement(join(1658571..1660952,1661002..1661190,1661243..1661382,1661439..1661536,1661603..1661876,1661972..1662053)) V 1 NT_166531.1 Function: a role for mouse Mms19 protein in the assembly of a multiprotein complex(es) required for NER and RNAP II transcription has been suggested.; Function: mouse MMS19 is a polypeptide of unknown function which is required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription.; Title: strong similarity to MMS19 - Mus musculus; See PMID 11328871; uncharacterized protein 1662053 4989128 An16g07360 Aspergillus niger uncharacterized protein XP_001398036.1 1658571 R 5061 CDS An16g07370 4989129 join(1662594..1662953,1663059..1663151) V 1 NT_166531.1 Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger EST Nig076 .; Title: similarity to hypothetical protein SPBC146.10 - Schizosaccharomyces pombe; uncharacterized protein 1663151 4989129 An16g07370 Aspergillus niger uncharacterized protein XP_059606785.1 1662594 D 5061 CDS An16g07380 4989130 complement(join(1663307..1663347,1663420..1663596,1663668..1663853,1663884..1664247,1664310..1664343,1664413..1664462)) V 1 NT_166531.1 Title: strong similarity to hypothetical cDNA MGC:7080 - Mus musculus; uncharacterized protein 1664462 4989130 An16g07380 Aspergillus niger uncharacterized protein XP_059606786.1 1663307 R 5061 CDS An16g07390 4989131 join(1664778..1664823,1664949..1665247,1665310..1665594) V 1 NT_166531.1 Complex: S. cerevisiae SPC associates with Sbh1p and Sbh2p, the beta-subunits of the Sec61p complex and the Ssh1p complex, respectively.; Complex: in S. cerevisiae the SPC is formed by a heterotetramer of Sec11p, Spc3p, Spc1p and Spc2p.; Function: S. cerevisiae Spc2 is a subunit of the endoplasmatic reticulum signal peptidase complex, and is homologous to the mammalian protein SPC25.; Function: S. cerevisiae Spc2p not only enhances the enzymatic activity of the SPC but also facilitates the interactions between different components of the translocation site.; Function: mutations in S. cerevisiae Spc2 only disrupt signal peptidase complex (SPC) activity at high temperatures.; Remark: alternative names for S. cerevisiae SPC2 are SPY1 andYML055w.; Title: strong similarity to endoplasmatic reticulum signal peptidase subunit Spc2 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 8910564; See PMID 10921929; uncharacterized protein 1665594 4989131 An16g07390 Aspergillus niger uncharacterized protein XP_001398039.1 1664778 D 5061 CDS An16g07400 4989132 complement(join(1666013..1666096,1666155..1666244,1666307..1666940,1667120..1667316)) V 1 NT_166531.1 Catalytic activity: Methylenetetrahydrofolate dehydrogenases convert 5,10-methylenetetrahydrofolate + NAD(+) to 5,10-methenyltetrahydrofolate + NADH.; Function: S. cerevisiae MTD1 is involved in the oxidation of cytoplasmic one-carbon units for the de novo purine biosynthesis.; Regulation: S. cerevisiae MTD1 expression is repressed by adenine and requires the transcription factors Baslp and Bas2p.; Remark: the 5'UTR of the predicted A. niger protein is covered by the A. niger EST an_2989 .; Title: strong similarity to NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase Mtd1 -Saccharomyces cerevisiae; cytoplasm; See PMID 8416923; See PMID 8608153; See PMID 9749667; uncharacterized protein 1667316 4989132 An16g07400 Aspergillus niger uncharacterized protein XP_001398040.1 1666013 R 5061 CDS An16g07410 4989133 complement(join(1668325..1669575,1669636..1669756,1669818..1669874,1670010..1670179,1670357..1670428)) V 1 NT_166531.1 Remark: in S. cerevisiae three copies of the ATP1 gene exist on Chr. II within a 20kb region.; Title: strong similarity to mitochondrial F1-ATPase alpha-subunit Atp1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8690725; See PMID 2876995; uncharacterized protein 1670428 4989133 An16g07410 Aspergillus niger uncharacterized protein XP_001398041.1 1668325 R 5061 CDS An16g07420 4989134 complement(join(1671690..1672141,1672208..1672267,1672316..1672343,1672411..1672443)) V 1 NT_166531.1 Remark: according to A. niger EST an_3502 a possible sequencing error occured at position 45296 leading to a missing splice site, 1 base has been changed from G to A.; Title: strong similarity to hypothetical protein AAF27107.1 - Arabidopsis thaliana [putative sequencing error]; uncharacterized protein 1672443 4989134 An16g07420 Aspergillus niger uncharacterized protein XP_059606787.1 1671690 R 5061 CDS An16g07430 4989135 join(1673286..1673534,1673593..1673673,1673738..1673911) V 1 NT_166531.1 Complex: in S. pombe the DNA-dependent RNA-polymerase II consists of 11 subunits, RPBs 1-8 and 10-12, with the large subunits Rpb1+2 forming the scaffold for the assemlby of the smaller subunits.; Function: RNA polymerase II of S. pombe catalyses DNA-template-directed extension of the 3'-end of an mRNA strand by one nucleotide at a time.; Title: strong similarity to 19 kD subunit of DNA-directed RNA polymerase II rpb7p - Schizosaccharomyces pombe; nucleus; See PMID 9322754; See PMID 9642054; uncharacterized protein 1673911 4989135 An16g07430 Aspergillus niger uncharacterized protein XP_001398043.1 1673286 D 5061 CDS An16g07440 4989136 join(1675420..1675728,1675802..1676989) V 1 NT_166531.1 Title: similarity to hypothetical protein B23L4.080 - Neurospora crassa; uncharacterized protein 1676989 4989136 An16g07440 Aspergillus niger uncharacterized protein XP_001398044.1 1675420 D 5061 CDS An16g07450 4989137 complement(join(1677997..1679496,1679549..1679793,1679867..1681002,1681066..1681391)) V 1 NT_166531.1 Function: N. crassa QDE2 controls transgene-induced gene silencing.; Function: the Drosophila QDE2 homologue, dAGO1,exerts its developmental functions by binding to RNA either directly or indirectly.; Function: the rabbit QDE2 homologue, eIF2C, forms part of a protein complex that stimulates the start of translation.; Localization: the rat QDE2 homologue, GERp95, is a cytoplasmically exposed peripheral membrane protein that exists in a protease-resistant complex and localizes primarily to the Golgi complex or the endoplasmic reticulum (ER), depending on cell type.; Title: strong similarity to protein involved in post-transcriptional gene silencing QDE2 - Neurospora crassa; See PMID 10512872; See PMID 10749199; See PMID 11318874; uncharacterized protein 1681391 4989137 An16g07450 Aspergillus niger uncharacterized protein XP_059606788.1 1677997 R 5061 CDS An16g07460 4989138 join(1683636..1683760,1683817..1684231,1684315..1684510,1684571..1684602,1684661..1685437,1685488..1686195,1686255..1686557) V 1 NT_166531.1 Remark: an alternative name for A. niger acuB is facB.; Similarity: the N-terminal region of the predicted A. niger protein contains a fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain; Title: strong similarity to acetate regulatory DNA binding protein facB - Aspergillus niger; See PMID 9197408; See PMID 10483720; uncharacterized protein 1686557 4989138 An16g07460 Aspergillus niger uncharacterized protein XP_059606789.1 1683636 D 5061 CDS An16g07470 84593503 join(1686990..1687017,1687346..1687507,1687559..1687565,1687644..1688156,1688228..1688663) V 1 NT_166531.1 Function: S. pombe gar2 helps the assembly of pre-ribosomal particles containing 18S rRNA.; Function: S. pombe gar2 helps the assembly on rRNA of factors necessary for 40S subunit synthesis by providing a physical link between them.; Localization: S. pombe gar2 has a nucleolar localization.; Title: similarity to mediator of 40S ribosomal subunit assembly gar2p - Schizosaccharomyces pombe; nucleus; See PMID 7596817; See PMID 9693363; uncharacterized protein 1688663 84593503 An16g07470 Aspergillus niger uncharacterized protein XP_059606790.1 1686990 D 5061 CDS An16g07480 4989140 join(1689073..1689243,1689321..1691114) V 1 NT_166531.1 Complex: Y. lipolytica Pay32p in the matrix is complexed with two polypeptides of 62 and 64 kD recognized by antibodies to SKL (peroxisomal targeting signal-1).; Function: Y. lipolytica PAY32 binds to the C-terminal pts1-type tripeptide peroxisomal targeting signal (skl-type) and plays an essential role in peroxisomal protein import.; Function: Y. lipolytica pay32 mutants fail to assemble functional peroxisomes.; Function: mutations in Y. lipolytica PAY32 prevent the translocation of most peroxisome-bound proteins into the peroxisomal matrix, these proteins instead are trapped in the peroxisomal membrane at an intermediate stage of translocation.; Localization: Y. lipolytica Pay32 is intraperoxisomal, associated primarily with the inner surface of the peroxisomal membrane, but approximately 30% of Pay32p is localized to the peroxisomal matrix.; Title: strong similarity to peroxisomal matrix protein importer PAY32 - Yarrowia lipolytica; peroxisome; uncharacterized protein 1691114 4989140 An16g07480 Aspergillus niger uncharacterized protein XP_059606791.1 1689073 D 5061 CDS An16g07490 4989141 join(1691548..1691799,1691880..1693210,1693259..1693490) V 1 NT_166531.1 Catalytic activity: 2-hydroxyphytanoyl-CoA lyases convert 2-hydroxyphytanoyl-CoA to pristanal.; Cofactor: human 2-hydroxyphytanoyl-CoA lyase depend on Mg(2+) and thiamine pyrophosphate.; Function: human 2-hydroxyphytanoyl-CoA lyase catalyses the second step of the alpha-oxidation of 3-methyl-branched fatty acids such as phytanic acid,catalysing a carbon-carbon cleavage.; Title: strong similarity to 2-hydroxyphytanoyl-CoA lyase - Homo sapiens; peroxisome; See PMID 10468558; uncharacterized protein 1693490 4989141 An16g07490 Aspergillus niger uncharacterized protein XP_059606792.1 1691548 D 5061 CDS An16g07500 4989142 complement(join(1693597..1693715,1693785..1694067,1694127..1694167,1694365..1694639,1694692..1694915,1694969..1695081,1695148..1695586)) V 1 NT_166531.1 Catalytic activity: amidases convert a monocarboxylic acid amide + H2O to a monocarboxylate + NH3.; Function: A. nidulans amdS hydrolyses acetamide to acetate and ammonium thus providing a source of carbon and nitrogen.; Regulation: regulation of A. nidulans amdS is complex and involves multiple regulatory transcription factors like amdR and amdX.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to acetamidase amdS -Aspergillus nidulans; See PMID 3036667; See PMID 7847883; See PMID 9044292; uncharacterized protein 1695586 4989142 An16g07500 Aspergillus niger uncharacterized protein XP_059606793.1 1693597 R 5061 CDS An16g07510 4989143 complement(join(1696100..1696157,1696214..1696389,1696452..1697424,1697481..1697968)) V 1 NT_166531.1 Title: similarity to hypothetical protein F13M7.11 -Arabidopsis thaliana; uncharacterized protein 1697968 4989143 An16g07510 Aspergillus niger uncharacterized protein XP_059606794.1 1696100 R 5061 CDS An16g07520 4989144 join(1698101..1698398,1698535..1698706,1698777..1699393,1699453..1699628) V 1 NT_166531.1 Catalytic activity: cystein synthases convert O3-acetyl-L-serine + H(2)S to L-cysteine + acetate.; Title: strong similarity to cysteine synthase cysK -Rhodobacter sphaeroides; See PMID 9406390; uncharacterized protein 1699628 4989144 An16g07520 Aspergillus niger uncharacterized protein XP_059606795.1 1698101 D 5061 CDS An16g07530 4989145 complement(1700111..1701721) V 1 NT_166531.1 Title: weak similarity to hypothetical chromodomain-helicase-dna-binding protein CHD-2 - Homo sapiens; uncharacterized protein 1701721 4989145 An16g07530 Aspergillus niger uncharacterized protein XP_001398053.3 1700111 R 5061 CDS An16g07540 4989146 join(1702393..1702508,1702549..1704139) V 1 NT_166531.1 Function: mouse beclin has autophagy-promoting activity and is associated with inhibition of tumourgenesis and antiviral host defense.; Title: strong similarity to bcl-2-interacting protein beclin - Mus musculus; See PMID 9765397; See PMID 10604474; uncharacterized protein 1704139 4989146 An16g07540 Aspergillus niger uncharacterized protein XP_059606796.1 1702393 D 5061 CDS An16g07550 84593504 complement(join(1705733..1705755,1705800..1705803,1705905..1705926,1705958..1706048,1706162..1706182,1706367..1706407,1706590..1706612)) V 1 NT_166531.1 Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1706612 84593504 An16g07550 Aspergillus niger uncharacterized protein XP_059606797.1 1705733 R 5061 CDS An16g07560 4989148 complement(<1710065..1711709) V 1 NT_166531.1 Title: strong similarity to transposase Tan1 -Aspergillus niger [putative frameshift]; putative frameshift; See PMID 9003286; uncharacterized protein 1711709 4989148 An16g07560 Aspergillus niger uncharacterized protein XP_059606798.1 1710065 R 5061 CDS An16g07580 4989149 join(1713442..1713825,1713896..1714232,1714281..1714377,1714547..1714775) V 1 NT_166531.1 Title: strong similarity to EST an_2194 -Aspergillus niger; uncharacterized protein 1714775 4989149 An16g07580 Aspergillus niger uncharacterized protein XP_059606799.1 1713442 D 5061 CDS An16g07590 84593505 complement(join(1715424..1715534,1715936..1716031,1716109..1716234,1716329..1716524,1716698..1716714)) V 1 NT_166531.1 hypothetical protein 1716714 84593505 An16g07590 Aspergillus niger hypothetical protein XP_059606800.1 1715424 R 5061 CDS An16g07600 84593506 join(1716971..1717014,1717186..1717210,1717297..1717354,1717484..1717490,1717580..1717645,1717712..1717733) V 1 NT_166531.1 Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1717733 84593506 An16g07600 Aspergillus niger uncharacterized protein XP_059606801.1 1716971 D 5061 CDS An16g07610 4989152 complement(join(1718334..1719103,1719162..1719636)) V 1 NT_166531.1 Complex: P. pastoris Pex13p together with Pex14p and Pex17p forms the peroxisomal translocation machinery.; Function: P. pastoris Pex13p binds the PTS1 receptor (Pex5p) via a cytoplasmically oriented SH3 domain.; Function: P. pastoris Pex13p is a component of the peroxisomal translocation machinery.; Function: loss of P. pastoris Pex13p eliminates import of peroxisomal matrix proteins that contain either the type-1 or type-2 peroxisomal targeting signal but does not affect targeting and insertion of integral peroxisomal membrane proteins.; Localization: P. pastoris Pex13p is an integral peroxisomal membrane protein.; Similarity: P. pastoris Pex13p contains a SH3 domain.; Title: strong similarity to peroxisomal docking factor Pex13 - Pichia pastoris; peroxisome; See PMID 8858165; uncharacterized protein 1719636 4989152 An16g07610 Aspergillus niger uncharacterized protein XP_001398060.3 1718334 R 5061 CDS An16g07620 4989153 complement(join(1720511..1720646,1720705..1722272,1722355..1722453)) V 1 NT_166531.1 Complex: S. cerevisiae Ero1 is a FAD-binding protein and binds to PDI.; Function: S. cerevisiae Ero1 is required for correct folding of disulfide-bonds containing proteins in the ER.; Function: S. cerevisiae Ero1 oxidises protein disulfide isomerase (PDI) via direct dithiol-disulfide exchange, which in turn oxidises disulfide-bond containing proteins in the ER.; Remark: the systematic name for S. cerevisiae Ero1 is YML130c.; Title: strong similarity to endoplasmatic reticulum oxidising protein Ero1 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 9659913; See PMID 10549279; See PMID 11090354; uncharacterized protein 1722453 4989153 An16g07620 Aspergillus niger uncharacterized protein XP_001398061.1 1720511 R 5061 CDS An16g07630 4989154 complement(join(1723909..1724028,1724083..1724733)) V 1 NT_166531.1 Title: weak similarity to hypothetical protein YDR348c - Saccharomyces cerevisiae; uncharacterized protein 1724733 4989154 An16g07630 Aspergillus niger uncharacterized protein XP_001398062.1 1723909 R 5061 CDS An16g07640 4989155 join(1726871..1727120,1727210..1727435,1727508..1727865,1727928..1727951) V 1 NT_166531.1 Title: strong similarity to hypothetical protein FLJ13154 - Homo sapiens; uncharacterized protein 1727951 4989155 An16g07640 Aspergillus niger uncharacterized protein XP_059606802.1 1726871 D 5061 CDS An16g07650 4989156 join(1728932..1728964,1729040..>1729590) V 1 NT_166531.1 Remark: a putative sequencing error results in a frameshift.; Title: weak similarity to hypothetical membrane protein YLR106c - Saccharomyces cerevisiae [putative frameshift]; putative frameshift; uncharacterized protein 1729590 4989156 An16g07650 Aspergillus niger uncharacterized protein XP_059606803.1 1728932 D 5061 CDS An16g07660 4989157 complement(join(1730335..1730504,1730555..1730638,1730708..1730944,1730994..1731608,1731685..1731838)) V 1 NT_166531.1 Function: B abortus gluP is a glucose and galactose transporter.; Remark: C-terminal region and 3'UTR of the predicted A. niger protein are in accordance with the A. niger EST an_2695 EMBLEST:BE759781.; Similarity: B abortus gluP is a member of the major facilitator superfamily.; Title: similarity to glucose and galactose transporter gluP - Brucella abortus; See PMID 9168605; uncharacterized protein 1731838 4989157 An16g07660 Aspergillus niger uncharacterized protein XP_001398065.1 1730335 R 5061 CDS An16g07670 84593507 join(1733278..1733286,1733411..1733550,1733681..1733768,1733865..1733878,1734208..1734409) V 1 NT_166531.1 hypothetical protein 1734409 84593507 An16g07670 Aspergillus niger hypothetical protein XP_059606804.1 1733278 D 5061 CDS An16g07680 4989159 join(1734815..1735005,1735060..1735146,1735203..1735534,1735586..1735726,1735779..1735993,1736043..1736240,1736306..1736449,1736497..1736580) V 1 NT_166531.1 Function: N. crassa mtr is required for neutral,aliphatic and aromatic amino acid transport across the plasma membrane.; Title: strong similarity to neutral amino acid permease mtr - Neurospora crassa; See PMID 1838345; uncharacterized protein 1736580 4989159 An16g07680 Aspergillus niger uncharacterized protein XP_001398067.1 1734815 D 5061 CDS An16g07690 4989160 complement(join(1737179..1738281,1738347..1739109)) V 1 NT_166531.1 Remark: an A. niger EST ID NO:4166, PATENTDNA:F11643, covers the 5'UTR and the N-terminus of the predicted A. niger protein.; Title: similarity to hypothetical protein B2I10.030 - Neurospora crassa; uncharacterized protein 1739109 4989160 An16g07690 Aspergillus niger uncharacterized protein XP_001398068.3 1737179 R 5061 CDS An16g07700 4989161 1739989..1740927 V 1 NT_166531.1 Catalytic activity: dihydrodipicolinate synthases convert l-aspartate 4-semialdehyde + pyruvate to dihydrodipicolinate + 2 H(2)O.; Complex: C. glutamicum dapA forms a homotetramer.; Function: C. glutamicum dapA catalyses the first step in the biosynthesis of diaminopimelate and lysine from aspartate semialdehyde.; Repression: C. glutamicum dapA is sensitive to lysine inhibition.; Similarity: C. glutamicum dapA belongs to the dhdps family.; Title: similarity to dapA - Corynebacterium glutamicum; See PMID 8092856; See PMID 2129555; uncharacterized protein 1740927 4989161 An16g07700 Aspergillus niger uncharacterized protein XP_001398069.3 1739989 D 5061 CDS An16g07710 4989162 complement(join(1741057..1741599,1741654..1742907)) V 1 NT_166531.1 Catalytic activity: carboxylesterases convert a carboxylic ester + H(2)O to an alcohol + a carboxylic anion.; Function: Rhodococcus cocE does initiate degradation of cocaine for the utilisation as carbon and nitrogen source.; Title: similarity to cocaine esterase cocE -Rhodococcus sp.; See PMID 10698749; uncharacterized protein 1742907 4989162 An16g07710 Aspergillus niger uncharacterized protein XP_001398070.1 1741057 R 5061 CDS An16g07720 4989163 complement(join(1743431..1743700,1743763..1744269)) V 1 NT_166531.1 Title: weak similarity to outer surface protein D ospD - Borrelia garinii; uncharacterized protein 1744269 4989163 An16g07720 Aspergillus niger uncharacterized protein XP_001398071.1 1743431 R 5061 CDS An16g07730 84593508 join(1745319..1745476,1745538..1745595,1745670..1745689,1745818..1745909,1745965..1746080) V 1 NT_166531.1 hypothetical protein 1746080 84593508 An16g07730 Aspergillus niger hypothetical protein XP_059606805.1 1745319 D 5061 CDS An16g07740 84593509 join(1747517..1747629,1747726..1747981,1748078..>1748176) V 1 NT_166531.1 Remark: ORF 3'truncated due to end of contig.; Title: similarity to hypothetical protein T18N14.80 - Arabidopsis thaliana [truncated ORF]; uncharacterized protein 1748176 84593509 An16g07740 Aspergillus niger uncharacterized protein XP_059606806.1 1747517 D 5061 CDS An16g07750 4989166 join(1748617..1748644,1748720..1748884,1748943..1748975,1749070..1749197,1749332..1749449,1749533..1749713,1749803..1750018,1750090..1750199,1750288..1750348,1750402..1750540) V 1 NT_166531.1 hypothetical protein 1750540 4989166 An16g07750 Aspergillus niger hypothetical protein XP_001398074.3 1748617 D 5061 CDS An16g07760 84593510 join(1751900..1752191,1752266..1752537) V 1 NT_166531.1 hypothetical protein 1752537 84593510 An16g07760 Aspergillus niger hypothetical protein XP_059604897.1 1751900 D 5061 CDS An16g07770 84593511 join(1753685..1753704,1753735..1754065,1754139..1754354) V 1 NT_166531.1 hypothetical protein 1754354 84593511 An16g07770 Aspergillus niger hypothetical protein XP_059604898.1 1753685 D 5061 CDS An16g07780 84593512 complement(join(1755107..1755421,1755471..1755503)) V 1 NT_166531.1 hypothetical protein 1755503 84593512 An16g07780 Aspergillus niger hypothetical protein XP_059604899.1 1755107 R 5061 CDS An16g07795 4989170 join(1758548..1759114,1759169..1760647) V 1 NT_166531.1 Title: strong similarity to hypothetical protein CAC18184.2 - Neurospora crassa; uncharacterized protein 1760647 4989170 An16g07795 Aspergillus niger uncharacterized protein XP_059604900.1 1758548 D 5061 CDS An16g07800 4989171 join(1760961..1760968,1761107..1761269,1761448..1761891,1761943..1762144,1762166..1762359) V 1 NT_166531.1 Catalytic activity: ADP + ATP <=> phosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate.; Catalytic activity: GTP and adenosine tetraphosphate can also act as adenylyl acceptors.; Function: APA2 of S. cerevisiae sustains the catabolism of NP-4-N' nucleotides, rather than their synthesis.; Title: strong similarity to ATP adenylyltransferase Apa2 - Saccharomyces cerevisiae; See PMID 11007995; See PMID 2174863; uncharacterized protein 1762359 4989171 An16g07800 Aspergillus niger uncharacterized protein XP_059604901.1 1760961 D 5061 CDS An16g07810 4989172 complement(join(1763039..1763254,1763332..1764702)) V 1 NT_166531.1 hypothetical protein 1764702 4989172 An16g07810 Aspergillus niger hypothetical protein XP_001398080.1 1763039 R 5061 CDS An16g07820 84593513 complement(join(1766075..1766359,1766558..1766569,1766694..1766810,1766938..1767162)) V 1 NT_166531.1 hypothetical protein 1767162 84593513 An16g07820 Aspergillus niger hypothetical protein XP_059604902.1 1766075 R 5061 CDS An16g07830 4989174 complement(join(1768032..1768940,1769016..1769297,1769362..1769514,1769565..1769747)) V 1 NT_166531.1 Similarity: weak local similarity to probable two-component sensor histidine kinase yocF - Bacillus subtilis.; hypothetical protein 1769747 4989174 An16g07830 Aspergillus niger hypothetical protein XP_059604903.1 1768032 R 5061 CDS An16g07840 4989175 complement(1770300..1771571) V 1 NT_166531.1 Remark: M protein of S. pyogenes binds also human serum albumin and fibrinogen.; Remark: M protein of S. pyogenes is a major antigenic determinant which binds human IgG1, IgG2, IgG3 and IgG4, as well as horse, rabbit and pig IgG in a non-immune fashion.; Title: similarity to M protein emm55 - Streptococcus pyogenes; See PMID 7643859; uncharacterized protein 1771571 4989175 An16g07840 Aspergillus niger uncharacterized protein XP_059604904.1 1770300 R 5061 CDS An16g07850 4989176 join(1771819..1771848,1771895..1771999,1772189..1772263,1772354..1772461) V 1 NT_166531.1 Function: snRPG of H. sapiens is associated with small nuclear ribonucleoproteins (sn-RNP) U1, U2 U4/U6 and U5, necessary for mRNA splicing.; Remark: in humans, snRNPs represent the major targets for the so-called anti-Sm auto-antibodies which are diagnostic for systemic lupus erythematosus (SLE).; Similarity: the predicted ORF belongs to the snRNP Sm proteins family.; Title: strong similarity to small nuclear ribonucleoprotein G snRPG - Homo sapiens; nucleus; See PMID 7744013; uncharacterized protein 1772461 4989176 An16g07850 Aspergillus niger uncharacterized protein XP_059604905.1 1771819 D 5061 CDS An16g07860 4989177 complement(join(1773036..1773365,1773420..1774214,1774265..1774605,1774664..1777013)) V 1 NT_166531.1 Complex: TFIID of S. cerevisiae is composed of TBP,the TATA box binding protein, and 14 distinct TBP-associated factors (TAFs), which range in size from 17 to 150 kDa.; Complex: TSM1 of S. cerevisiae is a component of the TFIID general RNA polymerase II transcription factor complex.; Function: TFIID binding is thought to be the first step in transcription initiation, acting to nucleate the transcription complex, recruiting the rest of the factors through a direct interaction with TFIIB.; Phenotype: TSM1 null mutants of S. cerevisiae are inviable.; Remark: TSM1 of S. cerevisiae is also called TAF150 or YCR042C.; Title: strong similarity to subunit of transcription initiation factor TFIID Tsm1 - Saccharomyces cerevisiae; nucleus; See PMID 8178153; See PMID 10721692; See PMID 10788514; See PMID 1840512; uncharacterized protein 1777013 4989177 An16g07860 Aspergillus niger uncharacterized protein XP_059604906.1 1773036 R 5061 CDS An16g07870 4989178 join(1777756..1777764,1778105..1778230,1778293..1778336,1778392..1778469,1778519..1779425) V 1 NT_166531.1 Catalytic activity: CDP-ethanolamine + 1,2-diacylglycerol <=> CMP + a phosphatidylethanolamine.; Function: AAPT1 of G. max (soybean) shows substrate specificity both for CDP-choline and CDP-ethanolamine.; Function: aminoalcoholphosphotransferases (AAPTases) utilize diacylglycerols and cytidine diphosphate (CDP)-aminoalcohols as substrates in the synthesis of the abundant membrane lipids phosphatidylcholine and phosphatidylethanolamine.; Localization: the diacylglycerol cholinephosphotransferase CPT1 of S. cerevisiae is located in the endoplasmic reticulum.; Similarity: the predicted ORF shows strong similarity to various aminoalcoholphosphotransferases of yeasts, plants and animals.; Title: strong similarity to aminoalcoholphosphotransferase AAPT1 - Glycine max; See PMID 7994181; uncharacterized protein 1779425 4989178 An16g07870 Aspergillus niger uncharacterized protein XP_059604907.1 1777756 D 5061 CDS An16g07890 4989180 complement(join(1780782..1782336,1782371..1782519,1782632..1782647,1782732..1782793,1782852..1782905)) V 1 NT_166531.1 Function: pro1 is essential in S. macrospora for the formation of multicellular fruiting bodies called perithecia.; Similarity: strong similarity to the predicted zinc-finger protein 17E5. 150 of N. crassa.; Similarity: the N-terminal region of the predicted ORF contains a fungal Zn(2)-Cys(6) binuclear cluster domain, a cysteine-rich region that binds DNA, and is found in many fungal transcriptional activators.; Similarity: the similarity to pro1 of S. macrospora is due to the conserved fungal zinc-finger motiv.; Title: similarity to transcription factor pro1 -Sordaria macrospora; See PMID 10224253; uncharacterized protein 1782905 4989180 An16g07890 Aspergillus niger uncharacterized protein XP_001398087.3 1780782 R 5061 CDS An16g07900 4989181 join(1783316..1783529,1783603..1783653,1783704..1783880,1783931..1784143,1784225..1784440,1784577..1784789,1784856..1784913,1784971..1785102,1785186..1785370,1785445..1785611) V 1 NT_166531.1 Function: HNM1 of S. cerevisiae is the unique coline permease in yeast (Km of 0. 5 micromolar).; Phenotype: the ctr1 mutant is defective in choline and ethanolamine transport, but the mutation also confers hyper-resistance to the alkylating agent nitrogen mustard.; Regulation: in S. cerevisiae, expression of CTR1/HNM1 is regulated by the phospholipid precursors inositol and choline and this regulation involves the trans-acting factors Ino2p, Ino4p and Opi1p.; Regulation: in S. cerevisiae, the choline transport activity decreases upon addition of choline to the growth medium.; Remark: HMN1 of S. cerevisiae is also known as CTR1.; Similarity: HNM1 of S. cerevisiae belongs to the APC family, which encompasses amino acid permeases more related to the mammalian cationic amino-acid transporter family (Tea/ecoR).; Similarity: the protein also shows strong similarity to the putative GABA permease GabA of Aspergillus nidulans; the gene structure is very different.; Title: strong similarity to choline permease Hnm1 -Saccharomyces cerevisiae; plasma membrane; See PMID 8264542; See PMID 2203793; See PMID 7520996; uncharacterized protein 1785611 4989181 An16g07900 Aspergillus niger uncharacterized protein XP_059604908.1 1783316 D 5061 CDS An16g07910 4989182 complement(join(1786032..1786148,1786219..1786319,1786394..1786422,1786494..1786551,1786607..1786701,1786758..1786783,1786879..1787310)) V 1 NT_166531.1 Remark: a splice site was detected upstream of the START codon.; Title: weak similarity to protein fragment SEQ ID NO:32794 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 1787310 4989182 An16g07910 Aspergillus niger uncharacterized protein XP_001398089.3 1786032 R 5061 CDS An16g07920 4989183 join(1789283..1789388,1789451..1789545,1789613..1789978) V 1 NT_166531.1 Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to hypothetical protein EAA64623.1 - Aspergillus nidulans; uncharacterized protein 1789978 4989183 An16g07920 Aspergillus niger uncharacterized protein XP_001398090.1 1789283 D 5061 CDS An16g07930 84593514 join(1791191..1791328,1791414..1791560,1791618..1791647,1791711..1791751,1791824..1791843,1791926..1792022,1792079..1792105,1792158..1792193,1792249..1792381) V 1 NT_166531.1 Title: strong similarity to hypothetical protein encoded by An12g06140 - Aspergillus niger; uncharacterized protein 1792381 84593514 An16g07930 Aspergillus niger uncharacterized protein XP_059604909.1 1791191 D 5061 CDS An16g07940 4989185 join(1793194..1793326,1793387..1793431,1793494..1793774,1793828..1794844) V 1 NT_166531.1 Complex: FUS6 of A. thaliana is a component of the COP9 complex, which is a multi subunit protein conserved in plants and animals.; Complex: the COP9 complex is composed by eight subunits and is also called signalosome, because of its involvement in various signal transduction pathways.; Function: mutations in the FUS6 gene of A. thaliana cause severe developmental phenotypes, probably due to impairment of several signal transduction pathways.; Localization: FUS6 of A. thaliana is coimmunoprecipitated with the COP9 subunit of the COP9 complex, and both are located within the nucleus.; Remark: FUS6 of A. thaliana is also known as COP11.; Similarity: the COP9 complex is related to the 26S proteasome regulatory complex.; Similarity: the protein contains a homology domain of unclear function, called PCI or PINT motif; apparently,all of the characterized proteins containing PCI domains are parts of larger multi-protein complexes.; Title: strong similarity to FUSCA protein FUS6 -Arabidopsis thaliana; nucleus; See PMID 8130643; See PMID 8689678; See PMID 8953769; See PMID 9707402; uncharacterized protein 1794844 4989185 An16g07940 Aspergillus niger uncharacterized protein XP_001398092.1 1793194 D 5061 CDS An16g07950 4989186 complement(join(1795781..1796114,1796182..1796423,1796474..1796605)) V 1 NT_166531.1 Similarity: automatically detected similarities are due to repetitive amino acid stretches.; hypothetical protein 1796605 4989186 An16g07950 Aspergillus niger hypothetical protein XP_001398093.1 1795781 R 5061 CDS An16g07960 4989187 complement(join(1797500..1798930,1799017..1799268)) V 1 NT_166531.1 Title: similarity to hypothetical transporter protein AAM72702.1 - Chlorobium tepidum; uncharacterized protein 1799268 4989187 An16g07960 Aspergillus niger uncharacterized protein XP_059604910.1 1797500 R 5061 CDS An16g07970 4989188 join(1800015..1800038,1800093..1800197,1800303..1800816,1800949..1802444) V 1 NT_166531.1 Similarity: the protein shows a strong similarity to a genomic clone of A. thaliana whit unknown function.; Similarity: the similarity with Amfr of M. musculus is mainly due to the C3HC4 type zinc finger (RING finger).; Title: similarity to autocrine motility factor receptor Amfr - Mus musculus; See PMID 10456327; uncharacterized protein 1802444 4989188 An16g07970 Aspergillus niger uncharacterized protein XP_059604911.1 1800015 D 5061 CDS An16g07980 4989189 1803894..1805138 V 1 NT_166531.1 Remark: a splice site was detected upstream of the START codon.; Title: similarity to hypothetical protein encoded by An16g01890 - Aspergillus niger; uncharacterized protein 1805138 4989189 An16g07980 Aspergillus niger uncharacterized protein XP_001398096.1 1803894 D 5061 CDS An16g07990 4989190 join(1806209..1807725,1807781..1808306) V 1 NT_166531.1 Similarity: the weak similarity to CG13953 of D. melanogaster refers only to the N-terminus and is partially due to repetitive amino acid stretches.; Title: weak similarity to hypothetical protein encoded by CG13953 - Drosophila melanogaster; uncharacterized protein 1808306 4989190 An16g07990 Aspergillus niger uncharacterized protein XP_001398097.1 1806209 D 5061 CDS An16g08000 4989191 complement(join(1810040..1810851,1810943..1811018)) V 1 NT_166531.1 Complex: Rpp1 of S. cerevisiae also appear to be shared between RNase P and RNase MRP.; Complex: the RNaseP complex of S. cerevisiae,besides Rpp1, contains at least these further components: Pop1, Pop3, Pop4, Pop5, Pop6, Pop7, Pop8, and Rpr2.; Function: Rpp1 of S. cerevisiae is an essential protein subunit of nuclear RNase P required for processing of precursor tRNA and 35S precursor rRNA.; Localization: Rpp1 is located in the nucleus of S. cerevisiae.; Phenotype: depletion of Rpp1 in vivo leads to the accumulation of precursor tRNAs with unprocessed 5' and 3' termini and defects in rRNA maturation in S. cerevisiae.; Similarity: hypothetical protein YHR062c of S. cerevisiae is identical to Rpp1 (GENBANK Acc. AAB68389).; Title: strong similarity to protein subunit of nuclear RNaseP Rpp1 - Saccharomyces cerevisiae; nucleus; See PMID 9308968; See PMID 9620854; uncharacterized protein 1811018 4989191 An16g08000 Aspergillus niger uncharacterized protein XP_001398098.1 1810040 R 5061 CDS An16g08010 4989192 join(1811541..1811655,1811767..1812140,1812188..1812607,1812659..1812757) V 1 NT_166531.1 Function: Casein kinase II is thought to play an essential role in the control of cell division and differentiation in all eukaryotes.; Title: strong similarity to Casein kinase CK II -Arabidopsis thaliana; See PMID 7678767; See PMID 8061317; uncharacterized protein 1812757 4989192 An16g08010 Aspergillus niger uncharacterized protein XP_001398099.1 1811541 D 5061 CDS An16g08020 4989193 join(1814082..1814112,1814218..1814337,1814435..1816449,1816506..>1817509) V 1 NT_166531.1 Catalytic activity: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val).; Function: cyt-20 of N. crassa encodes both the cytosolic and mitochondrial valine--tRNA ligase.; Title: strong similarity to valine--tRNA ligase cyt-20 - Neurospora crassa [putative frameshift]; putative frameshift; uncharacterized protein 1817509 4989193 An16g08020 Aspergillus niger uncharacterized protein XP_059604912.1 1814082 D 5061 CDS An16g08030 4989194 join(1817937..1817950,1818011..1818983) V 1 NT_166531.1 Similarity: patentmatch against ovarian tissue derived protein 18 Y59741 Patentprot.; Title: strong similarity to ovarian tissue derived protein 18 from patent DE19816395-A1 - Homo sapiens; uncharacterized protein 1818983 4989194 An16g08030 Aspergillus niger uncharacterized protein XP_001398101.1 1817937 D 5061 CDS An16g08040 4989195 join(1819568..1819582,1819674..1819789,1819872..1819898,1820008..1820221,1820273..1820496,1820566..1820623) V 1 NT_166531.1 Title: strong similarity to hypothetical protein PMP24 - Mus musculus; uncharacterized protein 1820623 4989195 An16g08040 Aspergillus niger uncharacterized protein XP_001398102.1 1819568 D 5061 CDS An16g08050 84593515 complement(join(1821250..1821485,1821610..1822259,1822319..1822365,1822414..1822895,1822960..1822981,1823031..1823267)) V 1 NT_166531.1 Title: similarity to hypothetical protein CAD21260.1 - Neurospora crassa; uncharacterized protein 1823267 84593515 An16g08050 Aspergillus niger uncharacterized protein XP_059604913.1 1821250 R 5061 CDS An16g08060 4989197 1823277..1824800 V 1 NT_166531.1 Catalytic activity: Benzoate + NADPH + O2 = 4-Hydroxybenzoate + NADP+ + H2O; Function: the P450rm protein of R. minuta is involved in the dissimilation pathway starting from L-phenylalanine.; Function: the cytochrome P450 enzymes usually act as terminal oxidases in multicomponent electron transfer chains, called P450-containing monooxygenase systems.; Pathway: Phenylalanine metabolism; Title: strong similarity to isobutene-forming enzyme and benzoate 4-hydroxylase P450rm - Rhodotorula minuta; See PMID 7764227; See PMID 8002981; See PMID 8882724; See PMID 9349702; uncharacterized protein 1824800 4989197 An16g08060 Aspergillus niger uncharacterized protein XP_001398104.1 1823277 D 5061 CDS An16g08070 4989198 complement(join(1825325..1825688,1825775..1825908,1825963..1826473,1826564..1827081)) V 1 NT_166531.1 Similarity: patentmatch against fumonisin esterase R91277 Patentprot.; Title: strong similarity to fumonisin esterase from patent WO9606175-A2 - Exophiala spinifera; uncharacterized protein 1827081 4989198 An16g08070 Aspergillus niger uncharacterized protein XP_001398105.1 1825325 R 5061 CDS An16g08080 4989199 join(1828069..1828299,1828350..1828687,1828740..1829199,1829255..1829980) V 1 NT_166531.1 Similarity: patentmatch against transport protein AX066343_1 TremblNew.; Similarity: similarties to pro- and eukaryotic mutidrug-efflux transporters.; Title: strong similarity to transporter from patent WO0100804 - Corynebacterium glutamicum; uncharacterized protein 1829980 4989199 An16g08080 Aspergillus niger uncharacterized protein XP_001398106.1 1828069 D 5061 CDS An16g08090 4989200 complement(join(1830337..1830921,1830972..1831421,1831474..1831718,1831818..1831908)) V 1 NT_166531.1 Title: strong similarity to hypothetical protein B2J23.120 - Neurospora crassa; uncharacterized protein 1831908 4989200 An16g08090 Aspergillus niger uncharacterized protein XP_001398107.1 1830337 R 5061 CDS An16g08100 4989201 1833658..1834422 V 1 NT_166531.1 Catalytic activity: (-)-ureidoglycolate + H(2)O = glyoxylate + 2 NH(3) + CO(2).; Title: similarity to hypothetical ureidoglycolate hydrolase SPAC19G12.04 - Schizosaccharomyces pombe; uncharacterized protein 1834422 4989201 An16g08100 Aspergillus niger uncharacterized protein XP_059604914.1 1833658 D 5061 CDS An16g08110 4989202 complement(join(1834546..1836287,1836336..1837257,1837335..1837483,1837545..1837584)) V 1 NT_166531.1 Function: the S. cerevisiae MSH 1 protein is involved in mitochondrial DNA repair; it belongs to the DNA mismatch repair mutS family.; Title: strong similarity to protein Msh1 -Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 1334021; See PMID 1459447; uncharacterized protein 1837584 4989202 An16g08110 Aspergillus niger uncharacterized protein XP_059604915.1 1834546 R 5061 CDS An16g08120 4989203 1838146..>1844028 V 1 NT_166531.1 Function: S. cerevisiae Brr2p protein promotes RNA rearrangements, acting synergistically with other spliceosomal proteins, including the structurally related Prp2p and Prp16p.; Remark: 3'-truncated ORF due to end of contig.; Similarity: similarities in C-terminus extend over contig border.; Title: strong similarity to pre-mRNA splicing helicase Brr2 - Saccharomyces cerevisiae [truncated ORF]; nucleus; See PMID 11290703; uncharacterized protein 1844028 4989203 An16g08120 Aspergillus niger uncharacterized protein XP_001398110.1 1838146 D 5061 CDS An16g08130 4989204 complement(join(1844802..1845586,1845633..1845774,1845849..1846118,1846183..1847365,1847407..1847561)) V 1 NT_166531.1 Similarity: AmdX of A. nidulans belongs to the nuclear hormone receptors family.; Title: similarity to DNA binding regulatory protein amdX - Aspergillus nidulans; nucleus; See PMID 9044292; uncharacterized protein 1847561 4989204 An16g08130 Aspergillus niger uncharacterized protein XP_001398111.3 1844802 R 5061 CDS An16g08140 4989205 complement(join(1847984..1848291,1848358..1848808,1848864..1848944,1849004..1849156,1849211..1849381,1849434..1849520)) V 1 NT_166531.1 Catalytic activity: salcylate hydroxylases catalyze the reaction of salicylate + NADH + H+ + O2 = catechol + NAD+ + H2O + CO2.; Function: salicylate hydroxylase of P. putida catalyzes the decarboxylative hydroxylation of salicylate.; Pathway: salcylate hydroxylases belong to the lower napthalene catabolic pathway which involves conversion of salicylate to lower amphibolic intermediates.; Remark: nahg and salicylate 1-monooxygenase are alternative names for salicylate hydroxylase of P. putida.; Title: similarity to salicylate hydroxylase sal -Pseudomonas putida; See PMID 10920265; See PMID 8695632; uncharacterized protein 1849520 4989205 An16g08140 Aspergillus niger uncharacterized protein XP_001398112.1 1847984 R 5061 CDS An16g08150 4989206 join(1850672..1850703,1850799..1852965) V 1 NT_166531.1 Catalytic activity: DPP V of A. fumigatus hydrolyses X-Ala, His-Ser, and Ser-Tyr dipeptides at a neutral pH optimum.; Localization: DPP V of A. fumigatus is a secreted protein.; Title: strong similarity to dipeptidyl-peptidase V DPP V - Aspergillus fumigatus; extracellular/secretion proteins; See PMID 9045640; uncharacterized protein 1852965 4989206 An16g08150 Aspergillus niger uncharacterized protein XP_001398113.1 1850672 D 5061 CDS An16g08160 4989207 join(1853134..1853201,1853364..1854357) V 1 NT_166531.1 Title: similarity to hypothetical protein B16B8.310 - Neurospora crassa; uncharacterized protein 1854357 4989207 An16g08160 Aspergillus niger uncharacterized protein XP_001398114.3 1853134 D 5061 CDS An16g08170 4989208 complement(join(1854691..1855075,1855131..1855184,1855235..1855321,1855367..1855812,1855859..1856014,1856085..1856280,1856347..1856540)) V 1 NT_166531.1 Phenotype: Gain-of-function mutations of HOL1 confer non-selective cation transport.; Phenotype: the HOL1 null mutant unable to uptake histidinol or Na+.; Remark: YNR055C is the systematic name for HOL1.; Similarity: HOL1 is a member of major facilitator superfamily multidrug-resistance protein subfamily 1.; Title: strong similarity to multidrug resistance protein Hol1 - Saccharomyces cerevisiae; plasma membrane; See PMID 2405251; See PMID 8955402; uncharacterized protein 1856540 4989208 An16g08170 Aspergillus niger uncharacterized protein XP_059604916.1 1854691 R 5061 CDS An16g08180 4989209 complement(join(<1857878..1858422,1858475..1858593,1858711..1858864,1858897..1859087,1859165..1859284)) V 1 NT_166531.1 Catalytic activity: PKL12 of M. musculus catalyzes the reaction of ATP + a protein = ADP + a phosphoprotein.; Function: PKL12 of M. musculus is a protein kinase that acts on both serine and threonine residues.; Remark: myristoylated and palmitoylated serine-threonine kinase, TGF-beta stimulated factor 1,TSF-1, serine/threonine protein kinase 16, STK16, MPSK1,TSF1, EDPK and KRCT are alternative names for PKL12.; Remark: putative sequencing error at position 14768 one base pair too much.; Similarity: PKL12 of M. musculus belongs to the ser/thr family of protein kinases.; Title: similarity to palmitylated serine/threonine kinase PKL12 - Mus musculus [putative frameshift]; deleted EC_number 2.7.1.37; putative frameshift; See PMID 9712705; uncharacterized protein 1859284 4989209 An16g08180 Aspergillus niger uncharacterized protein XP_059604917.1 1857878 R 5061 CDS An16g08190 84593516 complement(join(1859411..1859741,1859834..1860147,1860266..1860316)) V 1 NT_166531.1 hypothetical protein 1860316 84593516 An16g08190 Aspergillus niger hypothetical protein XP_059604918.1 1859411 R 5061 CDS An16g08200 4989211 1860517..1862556 V 1 NT_166531.1 Function: dynactin is a major component of activator I, a 20s polypeptide complex that stimulates dynein-mediated vesicle transport.; Title: similarity to dynactin Chip150 - Gallus gallus; See PMID 1836789; uncharacterized protein 1862556 4989211 An16g08200 Aspergillus niger uncharacterized protein XP_059604919.1 1860517 D 5061 CDS An16g08210 4989212 complement(join(1863270..1863807,1863951..1863982)) V 1 NT_166531.1 Catalytic activity: BNA1 of S. cerevisiae catalyzes the reaction of 3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.; Pathway: BNA1 of S. cerevisiae is involved in nicotinic acid biosynthesis.; Remark: 3-hydroxyanthranilic acid dioxygenase,3-hydroxyanthranilate oxygenase HAD1, YJR025C, J1550 and 3-HAO are alternative names for BNA1 of S. cerevisiae.; Title: strong similarity to 3-hydroxyanthranilic acid dioxygenase Bna1 - Saccharomyces cerevisiae; See PMID 9539135; uncharacterized protein 1863982 4989212 An16g08210 Aspergillus niger uncharacterized protein XP_001398119.1 1863270 R 5061 CDS An16g08220 4989213 1864312..>1865530 V 1 NT_166531.1 Complex: associates with u3 snoRNP, but is not its structural component.; Function: RCL1 of S. cerevisiae does not have cyclase activity.; Function: RCL1 of S. cerevisiae plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites a0, a1 and a2, that are required for proper maturation of the 18S RNA.; Localization: nuclear; nucleolus.; Remark: RTC1 and YOL010W are alternative names for RCL1 of S. cerevisiae.; Remark: putative sequencing error at position 20385,one base pair too much.; Similarity: belongs to the RNA 3'-terminal cyclase family subfamily 2.; Title: similarity to RNA 3-phosphate cyclase-like protein Rcl1 - Saccharomyces cerevisiae [putative frameshift]; nucleus; putative frameshift; uncharacterized protein 1865530 4989213 An16g08220 Aspergillus niger uncharacterized protein XP_001398120.3 1864312 D 5061 CDS An16g08230 84593517 join(1866270..1866384,1866540..1866680,1866862..1866923,1867090..1867138,1867197..1867260,1867312..1867418,1867738..1867758,1867807..1867865) V 1 NT_166531.1 hypothetical protein 1867865 84593517 An16g08230 Aspergillus niger hypothetical protein XP_059604920.1 1866270 D 5061 CDS An16g08240 84593518 join(1869914..1869959,1870096..1870341,1870387..1870474,1870623..1870667,1870726..1870750,1870793..1870912) V 1 NT_166531.1 hypothetical protein 1870912 84593518 An16g08240 Aspergillus niger hypothetical protein XP_059604921.1 1869914 D 5061 CDS An16g08250 84593519 complement(join(1871626..1872192,1872272..1872373)) V 1 NT_166531.1 Remark: blastp matches are only due to repetitive amino acids.; hypothetical protein 1872373 84593519 An16g08250 Aspergillus niger hypothetical protein XP_059604922.1 1871626 R 5061 CDS An16g08260 84593520 complement(join(1873446..1873651,1873706..1873881,1874050..1874195)) V 1 NT_166531.1 hypothetical protein 1874195 84593520 An16g08260 Aspergillus niger hypothetical protein XP_059604923.1 1873446 R 5061 CDS An16g08270 84593521 complement(join(1874729..1874910,1875160..1875258,1875415..1875514)) V 1 NT_166531.1 hypothetical protein 1875514 84593521 An16g08270 Aspergillus niger hypothetical protein XP_059604924.1 1874729 R 5061 CDS An16g08280 84593522 join(1875932..1876089,1876218..1876284) V 1 NT_166531.1 hypothetical protein 1876284 84593522 An16g08280 Aspergillus niger hypothetical protein XP_059604925.1 1875932 D 5061 CDS An16g08290 84593523 complement(join(1877314..1877444,1877528..1877800,1878004..1878064)) V 1 NT_166531.1 hypothetical protein 1878064 84593523 An16g08290 Aspergillus niger hypothetical protein XP_059604926.1 1877314 R 5061 CDS An16g08300 84593524 complement(join(1878392..1878580,1878693..1878806,1878985..1879074,1879192..1879315,1879463..1879647)) V 1 NT_166531.1 hypothetical protein 1879647 84593524 An16g08300 Aspergillus niger hypothetical protein XP_059604927.1 1878392 R 5061 CDS An16g08310 84593525 join(1880333..1880379,1880470..1880524,1880631..1880670,1880763..1880824,1880911..1881171) V 1 NT_166531.1 hypothetical protein 1881171 84593525 An16g08310 Aspergillus niger hypothetical protein XP_059599558.1 1880333 D 5061 CDS An16g08320 84593526 join(1881338..1881418,1881516..1881666,1881712..1881910,1882017..1882104) V 1 NT_166531.1 hypothetical protein 1882104 84593526 An16g08320 Aspergillus niger hypothetical protein XP_059599559.1 1881338 D 5061 CDS An16g08330 4989224 complement(1882483..1883733) V 1 NT_166531.1 Catalytic activity: mae1 protein of S. pombe is catalyses C4-dicarboxylate (out) + nH+ (out) ---> C4-dicarboxylate (in) + nH+ (in).; Function: mae1 of S. pombe is involved in the uptake of L-malate, succinate and malonic acid by a proton symport mechanism.; Remark: mae1 of S. pomble belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.; Title: strong similarity to C4-dicarboxylate transport protein mae1p - Schizosaccharomyces pombe; plasma membrane; See PMID 10082980; uncharacterized protein 1883733 4989224 An16g08330 Aspergillus niger uncharacterized protein XP_001398131.1 1882483 R 5061 CDS An16g08340 84593527 join(1884121..1884198,1884247..1884343,1884442..1884564,1884650..1884674,1884750..1884860,1885005..1885113,1885190..1885312) V 1 NT_166531.1 hypothetical protein 1885312 84593527 An16g08340 Aspergillus niger hypothetical protein XP_059599560.1 1884121 D 5061 CDS An16g08350 84593528 join(1885346..1885446,1885491..1885586,1885709..1885853) V 1 NT_166531.1 hypothetical protein 1885853 84593528 An16g08350 Aspergillus niger hypothetical protein XP_059599561.1 1885346 D 5061 CDS An16g08360 4989227 complement(1886884..>1887939) V 1 NT_166531.1 Remark: N-terminally truncated ORF due to contig border.; Remark: no similarities of the predicted ORF to the highly conserved signal sequence or cell wall attachment region of the best blast match, the collagen-like surface protein SclA from S. pyogenes were found.; Title: weak similarity to cytochrome c1 of ubiquinol--cytochrome-c reductase - Paracoccus denitrificans [truncated ORF]; uncharacterized protein 1887939 4989227 An16g08360 Aspergillus niger uncharacterized protein XP_001398134.3 1886884 R 5061 CDS An16g08370 4989228 complement(join(1890012..1890042,1890247..1890887)) V 1 NT_166531.1 Function: Jac1 of S. cerevisiae, together with the Ssq1 70KDa chaperone protein, is essential for the formation of the Fe/S clusters of different proteins and for mitochondrial iron metabolism.; Localization: Jac1 of S. cerevisiae is located in the mitochondrial matrix.; Remark: Jac1 of S. cerevisiae is also known as YGL018C.; Similarity: Jac1 of S. cerevisiae belongs to the the 20-kDa J-protein family of co-chaperones; the name derives from the DnaJ protein of E. coli.; Title: similarity to mitochondrial J-type chaperone Jac1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9813017; See PMID 11171977; See PMID 11273703; uncharacterized protein 1890887 4989228 An16g08370 Aspergillus niger uncharacterized protein XP_001398135.3 1890012 R 5061 CDS An16g08380 4989229 complement(join(1891339..1891507,1891622..1892852,1892933..1892966,1893071..1893112)) V 1 NT_166531.1 Complex: PRP4 of S. cerevisiae is a protein of the U4/U6 small nuclear ribonucleoprotein particle (snRNP),required early in the spliceosome assembly pathway.; Function: as an essential component of the spliceosome, PRP4 of S. cerevisiae participate in the process of pre-mRNA splicing.; Phenotype: null mutation of PRP4 in S. cerevisiae is lethal.; Remark: PRP4 of S. cerevisiae is also called RNA4 or YPR178W.; Similarity: homologues of PRP4 were found in many different species, comprising A. thaliana and humans.; Title: strong similarity to U4/U6 snRNP 52kD protein Prp4 - Saccharomyces cerevisiae; nucleus; See PMID 10900456; See PMID 2528687; See PMID 3536128; See PMID 8202378; uncharacterized protein 1893112 4989229 An16g08380 Aspergillus niger uncharacterized protein XP_059602777.1 1891339 R 5061 CDS An16g08390 4989230 join(1893490..1893542,1894125..1895382) V 1 NT_166531.1 Function: althoug the functions of S. pombe AZR1 are not fully understood, the gene may be involved in resistance to 5-azacytidine.; Similarity: another region of the predicted ORF shows strong similarity to the AZR1 protein of S. pombe.; Similarity: the similarity to the A. pullulans ORF is limited to the C-terminal half of the protein.; Title: similarity to sequence 4 from patent WO0063399 - Aureobasidium pullulans; uncharacterized protein 1895382 4989230 An16g08390 Aspergillus niger uncharacterized protein XP_001398137.1 1893490 D 5061 CDS An16g08400 84593529 join(1896111..1896215,1896304..1896324,1896436..1896609) V 1 NT_166531.1 Similarity: the 35 N-terminal amino acids of the predicted ORF show similarity to the D. melanogaster CG15759 gene with unknown function.; hypothetical protein 1896609 84593529 An16g08400 Aspergillus niger hypothetical protein XP_059602778.1 1896111 D 5061 CDS An16g08410 4989232 complement(join(1896839..1897464,1897529..1897757,1897821..1898193,1898259..1898748,1898858..1899023)) V 1 NT_166531.1 Localization: in vertebrates neurofilaments are components of the cytoskeleton within neural cell cytoplasmic extensions.; Similarity: the predicted ORF contains a PWWP domain, named after a conserved Pro-Trp-Trp-Pro motif, whose function is currently unknown.; Similarity: the predicted ORF shows a stronger similarity to a S. pombe hypothetical protein.; Similarity: the similarity to NF-180 of P. marinus and other neurofilament proteins is mainly due to low complexity regions.; Title: similarity to neurofilament subunit NF-180 -Petromyzon marinus; cytoskeleton; See PMID 7770000; uncharacterized protein 1899023 4989232 An16g08410 Aspergillus niger uncharacterized protein XP_001398139.1 1896839 R 5061 CDS An16g08420 4989233 complement(join(1900651..1900683,1900736..1901027,1901059..1901476,1901537..1901761,1901819..1902071,1902180..1902572)) V 1 NT_166531.1 Similarity: shows strong similarity to a 5'-EST of the A. niger cDNA clone an_3071.; Title: similarity to hypothetical integral membrane protein SC10B7.28 - Streptomyces coelicolor; uncharacterized protein 1902572 4989233 An16g08420 Aspergillus niger uncharacterized protein XP_059602779.1 1900651 R 5061 CDS An16g08430 84593530 complement(join(1903772..1903932,1904002..1904070,1904181..1904300,1904385..1904682,1904767..1904835)) V 1 NT_166531.1 hypothetical protein 1904835 84593530 An16g08430 Aspergillus niger hypothetical protein XP_059602780.1 1903772 R 5061 CDS An16g08440 4989235 join(1906164..1906480,1906579..1906616,1906675..1906754,1906814..1906896,1906963..1907458) V 1 NT_166531.1 Title: similarity to hypothetical protein T6K22.50 -Arabidopsis thaliana; uncharacterized protein 1907458 4989235 An16g08440 Aspergillus niger uncharacterized protein XP_059602781.1 1906164 D 5061 CDS An16g08450 4989236 1907982..1910216 V 1 NT_166531.1 Similarity: contains a fungal-type DNA-binding Zn(2)-Cys(6) binuclear cluster domain.; Title: strong similarity to hypothetical transcriptional regulator SPCC417.09c - Schizosaccharomyces pombe; uncharacterized protein 1910216 4989236 An16g08450 Aspergillus niger uncharacterized protein XP_001398143.1 1907982 D 5061 CDS An16g08460 4989237 complement(join(1912007..1912032,1912091..1913941,1914000..1914030,1914096..1915082,1915140..1915421,1915610..1915807)) V 1 NT_166531.1 Function: Sla1p of S. cerevisiae is essential for the proper formation of the cortical actin cytoskeleton.; Function: Sla1p of S. cerevisiae is involved in cellular morphogenesis and polarization of the cortical cytoskeleton.; Similarity: the N-terminus contains three SH3 domains similar to those found in signal transduction proteins that function at the membrane/cytoskeleton interface.; Title: strong similarity to cytoskeleton assembly control protein Sla1 - Saccharomyces cerevisiae; cytoskeleton; See PMID 8335689; uncharacterized protein 1915807 4989237 An16g08460 Aspergillus niger uncharacterized protein XP_059602782.1 1912007 R 5061 CDS An16g08470 4989238 complement(join(1916820..1916858,1917010..1918383,1918442..1918558)) V 1 NT_166531.1 Function: OS-9 of H. sapiens is coamplified with the CDK4 gene in human sarcomas.; Title: similarity to hypothetical cell growth regulator OS-9 - Homo sapiens; See PMID 9562620; uncharacterized protein 1918558 4989238 An16g08470 Aspergillus niger uncharacterized protein XP_059602783.1 1916820 R 5061 CDS An16g08480 4989239 1919684..1920592 V 1 NT_166531.1 Function: pirin of H. sapiens interacts with the nuclear factor I/CCAAT box transcription factor (NFI/CTF1),which stimulates RNA polymerase II-driven transcription.; Localization: pirin of H. sapiens was found to be localized within dot-like subnuclear structures.; Title: strong similarity to cofactor of NFI/CTF1 transcription activator pirin - Homo sapiens; nucleus; See PMID 9079676; uncharacterized protein 1920592 4989239 An16g08480 Aspergillus niger uncharacterized protein XP_001398146.3 1919684 D 5061 CDS An16g08490 4989240 complement(join(1921052..1921494,1921558..1923202,1923272..1923499)) V 1 NT_166531.1 Function: PMT4 of S. cerevisiae transfers a mannosyl residue from dolichyl phosphate-D-mannose to seryl and threonyl residues in proteins.; Pathway: PMT4 of S. cerevisiae is involved in the O-glycosylation of proteins in the endoplasmatic reticulum.; Title: strong similarity to dolichyl-phosphate-D-mannose--protein O-mannosyltransferase Pmt4 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 8585318; uncharacterized protein 1923499 4989240 An16g08490 Aspergillus niger uncharacterized protein XP_059602784.1 1921052 R 5061 CDS An16g08500 4989241 complement(1924139..1925254) V 1 NT_166531.1 Title: weak similarity to hypothetical protein CG1703 - Drosophila melanogaster; uncharacterized protein 1925254 4989241 An16g08500 Aspergillus niger uncharacterized protein XP_001398148.1 1924139 R 5061 CDS An16g08510 4989242 join(1926786..1927760,1927817..1928181,1928269..1928368,1928423..1928446) V 1 NT_166531.1 Function: Tna1p of S. cerevisiae is involved in the uptake of nicotinic acid.; Remark: the systematic gene name of TNA1 of S. cerevisiae is YGR260w.; Similarity: belongs to the major facilitator superfamily (MFS).; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563; uncharacterized protein 1928446 4989242 An16g08510 Aspergillus niger uncharacterized protein XP_001398149.1 1926786 D 5061 CDS An16g08520 4989243 complement(join(1928985..1929050,1929087..1929096,1929189..1929599,1929720..1930099,1930151..1930227,1930291..1930327,1930381..1930593,1930693..1930754,1930821..1931052)) V 1 NT_166531.1 Function: Pth11p of M. grisea functions at the cell cortex as an upstream effector of appressorium differentiation in response to host surface recognition.; Pathway: Pth11p of M. grisea is involved in pathogenicity signaling.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529; uncharacterized protein 1931052 4989243 An16g08520 Aspergillus niger uncharacterized protein XP_059602785.1 1928985 R 5061 CDS An16g08530 4989244 join(1931253..1931411,1931472..1931604,1931813..1931936,1931992..1932443,1932512..1932831) V 1 NT_166531.1 Function: omtB of A. parasiticus converts demethylsterigmatocystin to sterigmatocystin.; Pathway: omtB of A. parasiticus is involved in the aflatoxin biosynthesis pathway.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Title: strong similarity to O-methyltransferase B omtB - Aspergillus parasiticus; See PMID 10806361; uncharacterized protein 1932831 4989244 An16g08530 Aspergillus niger uncharacterized protein XP_001398151.1 1931253 D 5061 CDS An16g08540 4989245 complement(join(1933480..1933502,1933546..1933905,1933945..1934638,1934696..1935205,1935245..1935475,1935559..1935693)) V 1 NT_166531.1 Complex: cytoplasmic dynein is a multisubunit complex consisting of several small, intermediate and large subunits.; Function: cytoplasmic dynein is a microtubule-based motor protein, which mediates movement of numerous intracellular organelles.; Title: strong similarity to cytoplasmic dynein intermediate chain 1 DNCI1 - Homo sapiens; cytoskeleton; See PMID 10049579; uncharacterized protein 1935693 4989245 An16g08540 Aspergillus niger uncharacterized protein XP_059602786.1 1933480 R 5061 CDS An16g08550 4989246 join(1936061..1936084,1936167..1936350,1936473..1936543) V 1 NT_166531.1 Complex: Tim11p of S. cerevisiae is part of the F0 complex of the proton-transporting mitochondrial ATP synthase.; Function: Tim11p of S. cerevisiae is essential for ATP synthase dimerization, which is thought to enhance the stability and efficiency of ATP synthase complexes.; Localization: F0 of ATP synthase is located in the inner mitochondrial membrane.; Remark: the systematic name of TIM11 of S. cerevisiae is YDR322c-a.; Similarity: matches several A. niger ESTs including the patent database entry PATENTDNA:AAF11558.; Title: strong similarity to ATP synthase coupling factor (F0) subunit e Tim11 - Saccharomyces cerevisiae; See PMID 9271204; See PMID 9857174; uncharacterized protein 1936543 4989246 An16g08550 Aspergillus niger uncharacterized protein XP_001398153.1 1936061 D 5061 CDS An16g08560 4989247 complement(join(1937046..1937320,1937390..1937571,1937632..1937828)) V 1 NT_166531.1 Function: COP9 of A. thaliana is involved in the control of a light-mediated developmental switch.; Similarity: COP9 of H. sapiens is homologous to COP9 of A. thaliana.; Similarity: shows homology to a protein of patent database entry PATENTPROT:AAW68581.; Title: similarity to COP9 protein homolog from patent US5831059-A - Homo sapiens; uncharacterized protein 1937828 4989247 An16g08560 Aspergillus niger uncharacterized protein XP_001398154.1 1937046 R 5061 CDS An16g08570 4989248 join(1938242..1938371,1938435..1938458,1938582..1938662,1938723..1939316,1939368..1940493,1940548..1940818) V 1 NT_166531.1 Complex: STT3 of S. cerevisiae is thought to participate in the OTase complex in substechiometric amounts or to be required for OTase assembly.; Function: stt3 of S. pombe is essential for OTase activity.; Localization: STT3 of S. cerevisiae is an integral membrane protein of the endoplasmatic reticulum.; Pathway: OTase of S. pombe facilitates the transfer of the core oligonucleotide from dolichyl-PP to Asn-protein (N-linked glycosylation).; Similarity: stt3 of S. pombe is homologous to STT3 of S. cerevisiae.; Title: strong similarity to translation initiation factor 3 47 kDa subunit stt3p - Schizosaccharomyces pombe; endoplasmatic reticulum; See PMID 10234787; See PMID 7588624; uncharacterized protein 1940818 4989248 An16g08570 Aspergillus niger uncharacterized protein XP_001398155.1 1938242 D 5061 CDS An16g08580 4989249 complement(join(1941385..1941464,1941602..1941726,1941888..1941901)) V 1 NT_166531.1 Similarity: shows homology to an EST of patent database entry PATENTDNA:AAF13645.; Title: similarity to EST SEQ ID NO:6168 from patent WO200056762-A2 - Aspergillus oryzae; uncharacterized protein 1941901 4989249 An16g08580 Aspergillus niger uncharacterized protein XP_001398156.1 1941385 R 5061 CDS An16g08590 4989250 complement(join(1942519..1942814,1942873..1942931,1943007..1943329,1943433..1943537,1943596..1943661,1943786..1943839)) V 1 NT_166531.1 hypothetical protein 1943839 4989250 An16g08590 Aspergillus niger hypothetical protein XP_059602787.1 1942519 R 5061 CDS An16g08600 84593531 complement(join(1943902..1944079,1944121..1944356)) V 1 NT_166531.1 hypothetical protein 1944356 84593531 An16g08600 Aspergillus niger hypothetical protein XP_059602788.1 1943902 R 5061 CDS An16g08610 4989252 1944738..1946117 V 1 NT_166531.1 Function: TRI101 of F. sporotrichioides converts isotrichodermol to isotrichodermin.; Pathway: TRI101 of F. sporotrichioides acts in the trichothecene biosynthesis pathway as well as in self-protection from the trichothecene toxins.; Title: similarity to trichothecene 3-O-acetyltransferase TRI101 - Fusarium sporotrichioides; See PMID 10583973; uncharacterized protein 1946117 4989252 An16g08610 Aspergillus niger uncharacterized protein XP_001398159.1 1944738 D 5061 CDS An16g08620 4989253 join(1946971..1947308,1947436..1947601,1947656..1947786,1947849..1948052,1948106..1948454,1948506..1949326,1949392..1949806) V 1 NT_166531.1 Function: PTA1 of S. cerevisiae is involved in pre-tRNA splicing.; Title: strong similarity to pre-tRNA processing protein Pta1 - Saccharomyces cerevisiae; See PMID 1508188; uncharacterized protein 1949806 4989253 An16g08620 Aspergillus niger uncharacterized protein XP_059602789.1 1946971 D 5061 CDS An16g08630 4989254 complement(join(1950897..1951547,1951612..1952098,1952158..1952224,1952284..1953160)) V 1 NT_166531.1 Function: Dep1p of S. cerevisiae is involved in the regulation of the expression of the phospholipid biosynthesis structural genes INO1, CHO1 and OPI3 in response to soluble lipid precursors.; Phenotype: dep1 mutants of S. cerevisiae display pleiotropic deficiencies in transcriptional activation and repression.; Title: similarity to regulator of phospholipid metabolism Dep1 - Saccharomyces cerevisiae; See PMID 8056324; uncharacterized protein 1953160 4989254 An16g08630 Aspergillus niger uncharacterized protein XP_001398161.1 1950897 R 5061 CDS An16g08640 4989255 join(1954646..1954729,1954799..1956280) V 1 NT_166531.1 Function: motif similarities suggest involvment in RNA processing activities.; Title: strong similarity to hypothetical RNA-binding protein SPAC16E8.06c - Schizosaccharomyces pombe; uncharacterized protein 1956280 4989255 An16g08640 Aspergillus niger uncharacterized protein XP_001398162.1 1954646 D 5061 CDS An16g08650 4989256 join(1957000..1957356,1957462..1957983) V 1 NT_166531.1 Remark: a splice site was detected upstream of the START codon.; hypothetical protein 1957983 4989256 An16g08650 Aspergillus niger hypothetical protein XP_001398163.1 1957000 D 5061 CDS An16g08660 84593532 complement(join(1958136..1958364,1958416..1958743,1958841..1958928)) V 1 NT_166531.1 hypothetical protein 1958928 84593532 An16g08660 Aspergillus niger hypothetical protein XP_059602790.1 1958136 R 5061 CDS An16g08670 4989258 join(1959046..1959224,1959315..1959552,1959618..1960367,1960410..1960544) V 1 NT_166531.1 Similarity: also shows similarity to an A. oryzae EST from patent WO200056762-A2 (PATENTDNA:AAF13997).; Title: strong similarity to hypothetical protein AAL92654.1 - Dictyostelium discoideum; uncharacterized protein 1960544 4989258 An16g08670 Aspergillus niger uncharacterized protein XP_001398165.3 1959046 D 5061 CDS An16g08680 4989259 1960886..1961449 V 1 NT_166531.1 Title: similarity to hypothetical protein CC3654 -Caulobacter crescentus; uncharacterized protein 1961449 4989259 An16g08680 Aspergillus niger uncharacterized protein XP_001398166.1 1960886 D 5061 CDS An16g08690 84593533 complement(1961768..1964482) V 1 NT_166531.1 hypothetical protein 1964482 84593533 An16g08690 Aspergillus niger hypothetical protein XP_059602791.1 1961768 R 5061 CDS An16g08700 4989261 complement(join(1966272..1966481,1966544..1968412)) V 1 NT_166531.1 Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: weak similarity to cylicin II - Bos taurus; uncharacterized protein 1968412 4989261 An16g08700 Aspergillus niger uncharacterized protein XP_001398168.1 1966272 R 5061 CDS An16g08710 4989262 join(1968905..1968916,1969003..1969101,1969204..1969300,1969364..1969450,1969509..1969572,1969629..1969806,1969879..1969923) V 1 NT_166531.1 Complex: S. cerevisiae Rpc25 is one of about 15 different subunits of the RNA polymerase III.; Remark: S. cerevisiae Rpc25 (C25), like Rpb7 (RNA PolII), is present in submolar ratios, easily dissociates from the enzyme, is essential for cell growth and viability, but is not required in certain transcription assays in vitro.; Remark: alternate names for S. cerevisiae Rpc25: YKL144c, C25, YKL1.; Similarity: S. cerevisiae Rpc25 is related to the S. cerevisiae RNA polymerase II subunit, Rpb7.; Title: strong similarity to 25 kD subunit of DNA-directed RNA Polymerase III Rpc25 - Saccharomyces cerevisiae; nucleus; See PMID 8065349; uncharacterized protein 1969923 4989262 An16g08710 Aspergillus niger uncharacterized protein XP_001398169.1 1968905 D 5061 CDS An16g08720 4989263 join(1970929..1971045,1971115..1971200,1971268..1971715,1971781..1972359) V 1 NT_166531.1 Catalytic activity: L-cystathionine + H(2)O <=> L-cysteine + NH(3) + 2-oxobutanoate.; Cofactor: Pyridoxal-phosphate.; Pathway: the cystathionine gamma-lyase MecB from A. chrysogenum is involved in cysteine metabolism.; Title: strong similarity to cystathionine-gamma-lyase mecB - Acremonium chrysogenum; See PMID 11254121; uncharacterized protein 1972359 4989263 An16g08720 Aspergillus niger uncharacterized protein XP_001398170.1 1970929 D 5061 CDS An16g08730 4989264 join(1973024..1973182,1973287..1973595,1973659..1974303) V 1 NT_166531.1 Similarity: the ORF encoded protein shows also significant similarity to the Arabidopsis thaliana protein fragment SEQ ID NO: 49688 from patent EP1033405-A2, but its function is not decribed.; Title: strong similarity to hypothetical protein YIL110w - Saccharomyces cerevisiae; uncharacterized protein 1974303 4989264 An16g08730 Aspergillus niger uncharacterized protein XP_001398171.1 1973024 D 5061 CDS An16g08740 4989265 complement(join(1974706..1974862,1974942..1975186,1975339..1975455)) V 1 NT_166531.1 Catalytic activity: NADH + ubiquinone <=> NAD(+) + ubiquinol.; Complex: N. crassa Nuo-17. 8 is part of the complex I of the respiratory chain. Complex I is composed of about 40 different subunits.; Function: Complex I is responsible for the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is ubiquinone.; Remark: the EC number from the database entry was corrected to EC 1. 6. 5. 3, as it is a component of the mitochondrial respiratory chain (transfer of electrons to ubiquinone).; Title: strong similarity to 17.8 kD subunit of NADH:ubiquinone reductase Nuo-17.8 - Neurospora crassa; localisation:mitochondrion; See PMID 8343129; uncharacterized protein 1975455 4989265 An16g08740 Aspergillus niger uncharacterized protein XP_001398172.1 1974706 R 5061 CDS An16g08750 84593534 complement(join(1976230..1976510,1976843..1976882)) V 1 NT_166531.1 hypothetical protein 1976882 84593534 An16g08750 Aspergillus niger hypothetical protein XP_059602792.1 1976230 R 5061 CDS An16g08760 4989267 join(1977193..1980236,1980574..1981462) V 1 NT_166531.1 Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: similarity to zinc metalloprotease ZmpB from patent WO9964610-A1 - Streptococcus pneumoniae; uncharacterized protein 1981462 4989267 An16g08760 Aspergillus niger uncharacterized protein XP_001398174.1 1977193 D 5061 CDS An16g08770 84593535 complement(join(1983550..1983647,1983735..1983810,1983886..1983933)) V 1 NT_166531.1 Title: weak similarity to hypothetical protein At2g40070 - Arabidopsis thaliana; uncharacterized protein 1983933 84593535 An16g08770 Aspergillus niger uncharacterized protein XP_059602793.1 1983550 R 5061 CDS An16g08780 4989269 join(1984778..1984931,1985013..1988413) V 1 NT_166531.1 Similarity: the ORF encoded protein shows significant domain similarity to many zinc finger and putative zinc finger transcription factors.; Title: similarity to zinc-finger transcription factor Cre1 - Trichoderma harzianum; nucleus; See PMID 8709949; uncharacterized protein 1988413 4989269 An16g08780 Aspergillus niger uncharacterized protein XP_059602794.1 1984778 D 5061 CDS An16g08790 84593536 complement(join(1990858..1990990,1991109..1991203,1991391..1991534,1991942..1991992)) V 1 NT_166531.1 hypothetical protein 1991992 84593536 An16g08790 Aspergillus niger hypothetical protein XP_059602795.1 1990858 R 5061 CDS An16g08800 4989271 join(1992608..1992613,1992732..1993471,1993533..1993796,1993860..1994555,1994621..1995500) V 1 NT_166531.1 Remark: Trichoderma reesei=Hypocrea jecorina.; Similarity: the ORF encoded protein shows significant domain similarity to many zinc finger and putative zinc finger transcription factors.; Title: similarity to zinc-finger transcription factor AceI - Trichoderma reesei; nucleus; See PMID 10681571; uncharacterized protein 1995500 4989271 An16g08800 Aspergillus niger uncharacterized protein XP_001398178.1 1992608 D 5061 CDS An16g08810 4989272 complement(join(1995832..1995887,1995970..1996096,1996170..1996292)) V 1 NT_166531.1 Title: weak similarity to hypothetical membrane protein YPL099c - Saccharomyces cerevisiae; uncharacterized protein 1996292 4989272 An16g08810 Aspergillus niger uncharacterized protein XP_001398179.1 1995832 R 5061 CDS An16g08820 4989273 join(1997798..1999907,1999965..2002858) V 1 NT_166531.1 Remark: alternate name for S. cerevisiae Yta7: YGR270w.; Similarity: S. cerevisiae Yta7 belongs to the AAA family of ATPases.; Title: strong similarity to hypothetical AAA-type ATPase Yta7 - Saccharomyces cerevisiae; uncharacterized protein 2002858 4989273 An16g08820 Aspergillus niger uncharacterized protein XP_001398180.1 1997798 D 5061 CDS An16g08830 4989274 join(2003425..2003524,2003593..2003915,2003988..2004377) V 1 NT_166531.1 Complex: Sec71 from S. cerevisiae forms a complex together with Sec61, Sec62, Sec63, Sec72, and Kar2.; Function: Sec71 from S. cerevisiae interacts with the signal peptide of a secretory precursor and transfers it to the translocation pore.; Function: Sec71 from S. cerevisiae is essential for growth at elevated temperatures.; Function: Sec71 from S. cerevisiae is required to attach or retain Sec72 in the Sec63 complex.; Function: Sec71 from S. cerevisiae plays a direct role in the translocation of some presecretory proteins into the endoplasmic reticulum.; Remark: synonyms for Sec71 from S. cerevisiae are Sec66, Hss1 and YBR171w.; Title: strong similarity to component of ER protein-translocation subcomplex Sec71 from patent WO9949028-A1 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 8253836; See PMID 8257794; See PMID 8257795; uncharacterized protein 2004377 4989274 An16g08830 Aspergillus niger uncharacterized protein XP_001398181.1 2003425 D 5061 CDS An16g08840 4989275 complement(2004824..2007397) V 1 NT_166531.1 Title: strong similarity to hypothetical protein CAE76483.1 - Neurospora crassa; uncharacterized protein 2007397 4989275 An16g08840 Aspergillus niger uncharacterized protein XP_001398182.1 2004824 R 5061 CDS An16g08850 4989276 join(2007693..2007806,2008004..2008018,2008077..2008150,2008204..2008438,2008493..2008632,2008679..2008952,2009003..2009124,2009174..2010161) V 1 NT_166531.1 Complex: p81 from X. laevis is a component of the Xenopus origin recognition complex.; Phenotype: Immunodepletion of p81 from Xenopus egg extracts completely abolishes chromosomal DNA replication.; Title: strong similarity to origin recognition complex associated protein p81 - Xenopus laevis; nucleus; See PMID 9733795; uncharacterized protein 2010161 4989276 An16g08850 Aspergillus niger uncharacterized protein XP_059604928.1 2007693 D 5061 CDS An16g08860 4989277 join(2011712..2011999,2012060..2012274,2012365..2013224,2013256..2014535) V 1 NT_166531.1 Phenotype: S. cerevisiae spores harbouring disruptions in Nop14 germinated but underwent only a few divisions before ceasing growth, suggesting that Nop14 is essential for vegetative growth.; Remark: the synonym for Nop14 from S. cerevisiae is YDL148c.; Title: strong similarity to nuclear and nucleolar protein Nop14 - Saccharomyces cerevisiae; nucleus; See PMID 10487930; uncharacterized protein 2014535 4989277 An16g08860 Aspergillus niger uncharacterized protein XP_059604929.1 2011712 D 5061 CDS An16g08870 4989278 complement(join(2014933..2015976,2016029..2016376,2016447..2016671)) V 1 NT_166531.1 Catalytic activity: Triacylglycerol + H(2)O <=> diacylglycerol + a fatty acid anion.; Remark: Galactomyces geotrichum = Geotrichum candidum.; Remark: lipI from G. candidum belongs to the hydrolases acting on ester bonds.; Title: strong similarity to triacylglycerol lipase lipI - Geotrichum candidum; See PMID 2340308; See PMID 7737187; uncharacterized protein 2016671 4989278 An16g08870 Aspergillus niger uncharacterized protein XP_001398185.1 2014933 R 5061 CDS An16g08880 4989279 join(2017627..2017776,2017846..2018832) V 1 NT_166531.1 Similarity: the similarities to lower scored matches are based on repetetive structures.; Title: similarity to hypothetical protein T04H1.5 -Caenorhabditis elegans; uncharacterized protein 2018832 4989279 An16g08880 Aspergillus niger uncharacterized protein XP_001398186.1 2017627 D 5061 CDS An16g08890 4989280 complement(2019298..2020059) V 1 NT_166531.1 Function: Hydroxyproline-rich glycoproteins are the predominant components of the cell wall of the green alga Chlamydomonas reinhardtii.; Similarity: the similarities are based on repetetive structures.; Title: similarity to gamete-specific hydroxyproline-rich glycoprotein A2 - Chlamydomonas reinhardtii; See PMID 11258910; uncharacterized protein 2020059 4989280 An16g08890 Aspergillus niger uncharacterized protein XP_001398187.1 2019298 R 5061 CDS An16g08900 84593537 join(2020844..2021086,2021126..2021264,2021311..2021400,2021549..2021733) V 1 NT_166531.1 Title: weak similarity to atrophin-1 related protein from patent WO9921983-A1 - Homo sapiens; uncharacterized protein 2021733 84593537 An16g08900 Aspergillus niger uncharacterized protein XP_059604930.1 2020844 D 5061 CDS An16g08910 4989282 complement(2021929..2023206) V 1 NT_166531.1 Function: Srp40 from S. cerevisiae genetically interacts with four mutants affected in stable RNA synthesis and one mutant blocked in protein translocation to the endoplasmic reticulum.; Function: Srp40 from S. cerevisiae is phosphorylated by casein kinase II.; Localization: Srp40 from S. cerevisiae localizes in the nucleolus.; Phenotype: Growth defects, but no translocation or rRNA transcription/maturation phenotypes, were observed upon inactivation or strong overexpression ofSrp40 from S. cerevisiae .; Remark: the systematic name for Srp40 from S. cerevisiae is YKR092C.; Similarity: the similarities are based on repetetive structures.; Title: similarity to nucleolar protein Srp40 -Saccharomyces cerevisiae; See PMID 8702624; See PMID 9364927; uncharacterized protein 2023206 4989282 An16g08910 Aspergillus niger uncharacterized protein XP_001398189.3 2021929 R 5061 CDS An16g08920 4989283 join(2025910..2027246,2027396..2027465,2027556..2027573) V 1 NT_166531.1 Remark: strong evidence for a role of neurofilament phosphorylation in the establishment of neurofilament density and axonal caliber.; Remark: synonyms for NEFH from H. sapiens are NF-H,neurofilament triplet H protein and neurofilament protein.; Remark: the human NEFH subunit can get phosphorylated in axons.; Similarity: the human NEFH contains a KSP motif,named after a conserved Lys-Ser-Pro phosphorylation motif.; Title: similarity to neurofilament triplet H protein NEFH - Homo sapiens; cytoskeleton; See PMID 3138108; uncharacterized protein 2027573 4989283 An16g08920 Aspergillus niger uncharacterized protein XP_001398190.3 2025910 D 5061 CDS An16g08930 84593538 complement(join(2027709..2027884,2027956..2028147,2028244..2028328,2028525..2028642,2028995..2029182)) V 1 NT_166531.1 hypothetical protein 2029182 84593538 An16g08930 Aspergillus niger hypothetical protein XP_059604931.1 2027709 R 5061 CDS An16g08940 4989285 join(2030768..2031074,2031163..2031219,2031284..2032422) V 1 NT_166531.1 Remark: a splice site was detected upstream of the START codon.; Remark: the matching coding sequence was isolated by carrying out RT-PCR on mRNA obtained from A. thaliana.; Title: strong similarity to protein fragment SEQ ID NO:26152 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 2032422 4989285 An16g08940 Aspergillus niger uncharacterized protein XP_001398192.3 2030768 D 5061 CDS An16g08950 4989286 2033021..2035294 V 1 NT_166531.1 Remark: plays a crucial role in the association of the barbed ends of actin filaments with the plasma membrane in the cell-to-cell adherens junction and the cleavage furrow.; Title: similarity to radixin - Mus musculus; See PMID 195545; See PMID 1429901; uncharacterized protein 2035294 4989286 An16g08950 Aspergillus niger uncharacterized protein XP_001398193.1 2033021 D 5061 CDS An16g08960 84593539 join(2035855..2035894,2036082..2036175,2036233..2036307,2036940..2037091,2037173..2037322,2037432..2037608,2037702..2037786,2037859..2037977,2038088..2038172,2038293..2038409,2038522..2038629,2038714..2038804,2039013..2039222,2039304..2039606) V 1 NT_166531.1 hypothetical protein 2039606 84593539 An16g08960 Aspergillus niger hypothetical protein XP_059604932.1 2035855 D 5061 CDS An16g08980 4989288 join(2043639..2043892,2043979..2044169,2044268..2046447) V 1 NT_166531.1 Remark: contains a Zn(2)-Cys(6), fungal-type binuclear cluster domain.; Title: strong similarity to cutinase transcription factor beta CTF1b - Fusarium solani; See PMID 9139694; uncharacterized protein 2046447 4989288 An16g08980 Aspergillus niger uncharacterized protein XP_001398195.1 2043639 D 5061 CDS An16g08990 84593540 complement(join(2046957..2047091,2047236..2047284,2047384..2047460,2047578..2047661)) V 1 NT_166531.1 hypothetical protein 2047661 84593540 An16g08990 Aspergillus niger hypothetical protein XP_059604933.1 2046957 R 5061 CDS An16g09000 84593541 complement(join(2047940..2048068,2048169..2048279)) V 1 NT_166531.1 hypothetical protein 2048279 84593541 An16g09000 Aspergillus niger hypothetical protein XP_059604934.1 2047940 R 5061 CDS An16g09010 4989291 join(2048356..2048704,2048770..2048874,2048936..2049052,2049109..2049232,2049280..2049295,2049343..2049459,2049525..2049579,2049634..2049787,2049856..2049914,2049977..>2050543) V 1 NT_166531.1 Remark: a putative sequencing error results in a frameshift.; Title: strong similarity to carboxypeptidase I protein from patent WO9814599-A1 - Aspergillus oryzae [putative frameshift]; putative frameshift; See PMID 8224168; uncharacterized protein 2050543 4989291 An16g09010 Aspergillus niger uncharacterized protein XP_059604935.1 2048356 D 5061 CDS An16g09020 4989292 complement(join(2050995..2051223,2051293..2051388,2051467..2052074,2052132..2052725)) V 1 NT_166531.1 Title: strong similarity to hypothetical protein SPAC922.05c - Schizosaccharomyces pombe; uncharacterized protein 2052725 4989292 An16g09020 Aspergillus niger uncharacterized protein XP_001398199.1 2050995 R 5061 CDS An16g09030 84593542 join(2053301..2053421,2053504..2053569,2053667..2053891,2053978..2054105,2054210..2054407,2054499..2054547,2054719..2054783,2054874..2054974,2055182..2055344,2055441..2055470) V 1 NT_166531.1 hypothetical protein 2055470 84593542 An16g09030 Aspergillus niger hypothetical protein XP_059604936.1 2053301 D 5061 CDS An16g09040 4989294 join(2056105..2056479,2056570..2057469) V 1 NT_166531.1 Catalytic activity: N-acetyl-D-glucosamine 6-phosphate + H(2)O = D-glucosamine 6-phosphate + acetate.; Pathway: N-acetyl glucosamine utilization.; Title: strong similarity to N-acetylglucosamine-6-phosphate deacetylase CaNAG2 -Candida albicans; See PMID 11298769; uncharacterized protein 2057469 4989294 An16g09040 Aspergillus niger uncharacterized protein XP_001398201.1 2056105 D 5061 CDS An16g09050 4989295 complement(join(2058333..2059714,2059818..2060064)) V 1 NT_166531.1 Catalytic activity: alcohol + acceptor = aldehyde + reduced acceptor.; Cofactor: FAD.; Function: converts aliphatic medium-chain-length alcohols into aldehydes.; Remark: belongs to the GMC oxidoreductases family.; Title: strong similarity to alcohol dehydrogenase alkJ - Pseudomonas oleovorans; See PMID 1453953; uncharacterized protein 2060064 4989295 An16g09050 Aspergillus niger uncharacterized protein XP_001398202.1 2058333 R 5061 CDS An16g09060 4989296 join(2061713..2062194,2062303..2063317) V 1 NT_166531.1 Catalytic activity: betaine aldehyde + NAD(+) + H(2)O = betaine + NADH.; Complex: homotetramer.; Function: enzyme catalyzes the last step in the biosynthesis of betaine.; Pathway: betaine biosynthesis.; Remark: betaine is a protective osmolyte induced to accumulate by osmotic stress.; Title: strong similarity to betaine-aldehyde dehydrogenase betB - Escherichia coli; uncharacterized protein 2063317 4989296 An16g09060 Aspergillus niger uncharacterized protein XP_001398203.1 2061713 D 5061 CDS An16g09070 4989297 complement(join(2063900..2064751,2064831..2064978,2065082..2065147,2065211..2065212)) V 1 NT_166531.1 Catalytic activity: D-glucosamine 6-phosphate + H(2)O = D-fructose 6-phosphate + NH(3).; Complex: homohexamer.; Function: Isomerization of the aldose-ketose type converts the -CH(-NH2)-CH=O group of glucosamine 6-phosphate into -C(=NH)-CH2-OH, forming 2-deoxy-2-imino-D-arabino-hexitol, which then hydrolyses to yield fructose 6-phosphate and ammonia.; Induction: N-acetyl-D-glucosamine 6-phosphate, which is not broken down, activates the enzyme.; Pathway: N-acetyl glucosamine utilization.; Remark: EC 5. 3. 1. 10 was transferred to EC 3. 5. 99. 6; Title: strong similarity to glucosamine-6-phosphate deaminase from patent WO9835047-A1 - Escherichia coli; See PMID 2190615; See PMID 3284790; See PMID 8747459; See PMID 10378272; See PMID 1734962; uncharacterized protein 2065212 4989297 An16g09070 Aspergillus niger uncharacterized protein XP_059604937.1 2063900 R 5061 CDS An16g09080 84593543 join(2065538..2065573,2065656..2065812,2065927..2066011,2066350..2066524) V 1 NT_166531.1 hypothetical protein 2066524 84593543 An16g09080 Aspergillus niger hypothetical protein XP_059604938.1 2065538 D 5061 CDS An16g09090 4989299 join(2066739..2066934,2067064..2067404,2067565..2067724,2067986..2070498,2070564..2070677) V 1 NT_166531.1 Title: strong similarity to beta-N-acetylglucosaminidase nagA - Streptomyces thermoviolaceus; See PMID 9687451; uncharacterized protein 2070677 4989299 An16g09090 Aspergillus niger uncharacterized protein XP_059604939.1 2066739 D 5061 CDS An16g09100 84593544 join(2071045..2071157,2071384..2071447,2071532..2071672,2072269..2072379) V 1 NT_166531.1 Title: strong similarity to EST SEQ ID NO:4175 from patent WO200056762-A2 - Aspergillus niger; uncharacterized protein 2072379 84593544 An16g09100 Aspergillus niger uncharacterized protein XP_059604940.1 2071045 D 5061 CDS An16g09110 84593545 complement(join(2072569..2072643,2072731..2072962,2073038..2073081)) V 1 NT_166531.1 hypothetical protein 2073081 84593545 An16g09110 Aspergillus niger hypothetical protein XP_059604941.1 2072569 R 5061 CDS An16g09120 84593546 complement(join(2073714..2073844,2073942..2074017,2074073..2074361,2074531..2074592)) V 1 NT_166531.1 hypothetical protein 2074592 84593546 An16g09120 Aspergillus niger hypothetical protein XP_059604942.1 2073714 R 5061 CDS An16g09130 4989303 join(2077735..2077880,2077940..2079554) V 1 NT_166531.1 Function: the acid phosphatase activity encoded by the A. nidulans gene was demonstrated by cytochemistry.; Similarity: the predicted ORF is much more similar to Penicillium chrysogenum PHOG, that is a putative acid phosphatase based on the similarity to the A. nidulans gene.; Title: strong similarity to 35.6K acid phosphatase -Aspergillus nidulans; See PMID 7628710; See PMID 7916713; uncharacterized protein 2079554 4989303 An16g09130 Aspergillus niger uncharacterized protein XP_001398210.1 2077735 D 5061 CDS An16g09140 4989304 complement(join(2080476..2080957,2081011..2081158,2081228..2081740,2081773..2081816,2081864..2082062,2082172..2082474,2082549..2082716,2082809..2083122,2083171..2085151)) V 1 NT_166531.1 Complex: CFT1 of S. cerevisiae is a subunit of the cleavage factor II (CFII), a complex required for cleavage of the 3' end of pre-mRNA before polyadenylation.; Function: in mammals CPSF-160 is precisely involved in the recognition of the AAUAAA signal sequence for polyadenilation.; Remark: CFT1 of S. cerevisiae is also known as YHH1 or YDR301W.; Similarity: CFT1 of S. cerevisiae and the predicted protein are similar to the 160kDa subunit of mammalian cleavage and polyadenilation specificity factor CPSF-160.; Title: strong similarity to pre-mRNA 3-end processing factor CF II Cft1 - Saccharomyces cerevisiae; nucleus; See PMID 8929410; See PMID 9099738; See PMID 9303317; See PMID 10523662; uncharacterized protein 2085151 4989304 An16g09140 Aspergillus niger uncharacterized protein XP_059604943.1 2080476 R 5061 CDS An16g09150 4989305 join(2085735..2086284,2086378..2087376,2087439..2087620) V 1 NT_166531.1 Similarity: the predicted ORF shows strong similarity to some conceptual translations of human cDNAs; BM-021 was cloned from bone marrow RNA preparations.; Title: strong similarity to hypothetical protein BM-021 - Homo sapiens; uncharacterized protein 2087620 4989305 An16g09150 Aspergillus niger uncharacterized protein XP_001398212.1 2085735 D 5061 CDS An16g09160 4989306 complement(join(2087843..2087907,2087972..2088036,2088091..2088149,2088202..2088435)) V 1 NT_166531.1 Similarity: another A. niger EST, namely EMBLEST:BE760254, confirms the expression of the predicted ORF.; Title: strong similarity to EST AN05D03 -Aspergillus niger; uncharacterized protein 2088435 4989306 An16g09160 Aspergillus niger uncharacterized protein XP_001398213.1 2087843 R 5061 CDS An16g09170 4989307 join(2089020..2089049,2089135..2089161,2089463..2090111,2090200..2091137) V 1 NT_166531.1 hypothetical protein 2091137 4989307 An16g09170 Aspergillus niger hypothetical protein XP_001398214.3 2089020 D 5061 CDS An16g09180 4989308 join(2091906..2091951,2092084..2092272,2092334..2093478) V 1 NT_166531.1 Remark: There are two systems for zinc uptake in S. cerevisiae, one high-affinity and one lower-affinity.; Remark: ZRT2 of S. cerevisiae is also called YLR130C.; Similarity: ZRT2 and the high-affinity zinc transporter ZRT1 of S. cerevisiae are similar to each other, and are members of the ZIP family of heavy metal ion transporters.; Title: strong similarity to low affinity zinc transport protein Zrt2 - Saccharomyces cerevisiae; See PMID 8798516; See PMID 9271382; See PMID 9784581; See PMID 10748254; See PMID 10856230; uncharacterized protein 2093478 4989308 An16g09180 Aspergillus niger uncharacterized protein XP_001398215.1 2091906 D 5061 CDS An16g09190 4989309 complement(join(2094057..2094575,2094657..2095146,2095218..2095293,2095358..2095407,2095488..2095552)) V 1 NT_166531.1 Catalytic activity: ERG10 of S. cerevisiae encodes acetyl-CoA C-acetyltransferase (also called acetoacetyl-CoA thiolase), a cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA.; Pathway: the formation of acetoacetyl-CoA is the first step in the biosynthesis of mevalonate, which is required in turn for the biosynthesis of sterols and nonsterol isoprenoids.; Title: strong similarity to cytosolic acetyl-CoA C-acetyltransferase Erg10 - Saccharomyces cerevisiae; cytoplasm; See PMID 2900076; See PMID 7989303; See PMID 8754796; uncharacterized protein 2095552 4989309 An16g09190 Aspergillus niger uncharacterized protein XP_001398216.1 2094057 R 5061 CDS An16g09200 4989310 join(2095990..2096009,2096083..2096245,2096306..2098532,2098656..2099218) V 1 NT_166531.1 Similarity: although many of the BLASTP homologues to the predicted protein are annotated as translation elongation factor 2, this functional description is questionable, as it is normally based on sequence similarity.; Similarity: the best experimentally studied homologue is M. musculus U5-116kD, which indeed shows strong similarity to elongation factor 2, but is involved in pre-mRNA splicing and localizes in the nucleus, instead of being involved in protein synthesis and being located in the cytoplasm.; Title: strong similarity to U5 snRNP-specific protein U5-116kD - Mus musculus; nucleus; See PMID 9233818; uncharacterized protein 2099218 4989310 An16g09200 Aspergillus niger uncharacterized protein XP_059604944.1 2095990 D 5061 CDS An16g09210 4989311 complement(join(2099405..2099778,2099850..2100063)) V 1 NT_166531.1 Phenotype: null mutation of YHR122w in S. cerevisiae is lethal.; Title: strong similarity to hypothetical protein YHR122w - Saccharomyces cerevisiae; uncharacterized protein 2100063 4989311 An16g09210 Aspergillus niger uncharacterized protein XP_001398218.3 2099405 R 5061 CDS An16g09220 84593547 join(2100523..2100553,2100652..2100675,2100873..2100939,2101306..2101371,2101490..2101598) V 1 NT_166531.1 Title: questionable ORF; uncharacterized protein 2101598 84593547 An16g09220 Aspergillus niger uncharacterized protein XP_059604945.1 2100523 D 5061 CDS An16g09230 4989313 join(2103209..2103263,2103384..2103393,2103478..2103977,2104038..2104379,2104448..2104729,2104777..2105330,2105368..2105840,2105946..2106264) V 1 NT_166531.1 Function: the N. crassa nit-4 protein pathway-specific regulatory gene of nitrate assimilation. It activates the transcription of the genes for nitrate and nitrite reductases.; Similarity: in the predicted protein the fungal Zn(2)-Cys(6) binuclear cluster motif is not very conserved.; Similarity: the nit-4 protein from N. crassa is a fungal Zn(2)-Cys(6) binuclear type transcription factor.; Title: similarity to nitrogen assimilation regulatory protein nit-4 - Neurospora crassa; See PMID 1840634; See PMID 7592372; uncharacterized protein 2106264 4989313 An16g09230 Aspergillus niger uncharacterized protein XP_059604946.1 2103209 D 5061 CDS An16g09240 4989314 join(2107495..2107618,2107778..2108724) V 1 NT_166531.1 hypothetical protein 2108724 4989314 An16g09240 Aspergillus niger hypothetical protein XP_001398221.1 2107495 D 5061 CDS An16g09250 4989315 complement(join(2108934..2109281,2109383..2109856)) V 1 NT_166531.1 Function: RRF of T. thermophilus and other bacteria is required for decomposition of the post-termination complex of the ribosome after release of polypeptides.; Similarity: many eukaryotic proteins showing significant similarity to bacterial RRF were identified; some of them localize in subcellular compartments like mitochondria or chloroplasts; their function is still largely unclear.; Title: similarity to ribosome recycling factor RRF -Thermus thermophilus; See PMID 9258437; See PMID 10214965; uncharacterized protein 2109856 4989315 An16g09250 Aspergillus niger uncharacterized protein XP_001398222.1 2108934 R 5061 CDS An16g09255 84593548 complement(2110200..2110382) V 1 NT_166531.1 hypothetical protein 2110382 84593548 An16g09255 Aspergillus niger hypothetical protein XP_059604947.1 2110200 R 5061 CDS An16g09260 4989317 complement(join(2110566..2110834,2110885..2111365,2111425..2112132,2112205..2112370,2112418..2112544,2112601..2112651,2112707..2112749)) V 1 NT_166531.1 Complex: SSB2 of S. cerevisiae binds to ribosomes and nascent polypeptide chains.; Function: SSB2 of S. cerevisiae may aid in the passage of the nascent polypeptide chain through the ribosome channel into the cytosol.; Similarity: SSB2 of S. cerevisiae is almost identical to SSB1 of the same organism, probably indicating overlapping functions.; Similarity: the predicted protein is almost identical to hscA of A. nidulans, a putative protein belonging to the heat shock protein 70 family.; Title: strong similarity to dnaK-type molecular chaperone Ssb2 - Saccharomyces cerevisiae; cytoplasm; See PMID 1833403; See PMID 2651414; See PMID 8336673; See PMID 1394434; See PMID 1644272; uncharacterized protein 2112749 4989317 An16g09260 Aspergillus niger uncharacterized protein XP_001398224.1 2110566 R 5061 CDS An16g09270 4989318 join(2113919..2114022,2114080..2114224,2114283..2114341,2114392..2114428) V 1 NT_166531.1 Complex: CKS1 of S. cerevisiae is a protein that associates with the cyclin-dependent kinase CDC28 and is involved in cell cycle control.; Function: phosphorylation of SIC1 by G1-Cdk complexes is required for SIC1 degradation and entry into S phase.; Similarity: the ORF was modeled according to A. niger EST SEQ ID NO:3874 of patent WO200056762-A2, which comprises all the exons and the 5'- and 3'-UTRs.; Title: strong similarity to cyclin-dependent kinase regulatory subunit Cks1 - Saccharomyces cerevisiae; See PMID 2227411; See PMID 2664468; See PMID 2699737; See PMID 7958905; See PMID 8491379; uncharacterized protein 2114428 4989318 An16g09270 Aspergillus niger uncharacterized protein XP_001398225.1 2113919 D 5061 CDS An16g09280 4989319 complement(join(2114693..2114770,2114825..2114872,2114931..2115329,2115386..2115405,2115472..2115547)) V 1 NT_166531.1 Title: weak similarity to hypothetical protein AAF79893.1 - Arabidopsis thaliana; uncharacterized protein 2115547 4989319 An16g09280 Aspergillus niger uncharacterized protein XP_001398226.1 2114693 R 5061 CDS An16g09290 4989320 complement(join(2116019..2116069,2116107..2116268,2116325..2116880,2116927..2116996,2117128..2117605,2117938..2118069,2118115..2118223,2118274..2118398)) V 1 NT_166531.1 hypothetical protein 2118398 4989320 An16g09290 Aspergillus niger hypothetical protein XP_059604948.1 2116019 R 5061 CDS An16g09300 4989321 complement(join(2119243..2120431,2120499..2120638)) V 1 NT_166531.1 Similarity: the similarity to A. thaliana ReMembR-H2 and other proteins is due to the presence of a RING-finger motif, that is a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc, and is probably involved in mediating protein-protein interactions.; Title: weak similarity to RING finger protein ReMembR-H2 - Arabidopsis thaliana; See PMID 10953001; uncharacterized protein 2120638 4989321 An16g09300 Aspergillus niger uncharacterized protein XP_059604949.1 2119243 R 5061 CDS An16g09310 4989322 join(2121261..2121330,2121545..2121690,2121758..2121895,2121951..2122142) V 1 NT_166531.1 Catalytic activity: cis-trans isomerization of proline imidic peptide bonds in oligopeptides.; Function: PPIASEs accelerate the folding of proteins.; Regulation: PPIASEs bind Cyclosporin A (CsA); CsA mediates some of its effects via an inhibitory action on PPIASEs.; Similarity: the predicted protein shows strong similarity to several hypothetical and known peptidyl-prolyl cis-trans isomerase (PPIASEs), which bind cyclosporin A, and are therefore also called cyclophilins.; Title: strong similarity to peptidyl-prolyl cis-trans isomerase CYP - Lycopersicon esculentum; See PMID 1702215; uncharacterized protein 2122142 4989322 An16g09310 Aspergillus niger uncharacterized protein XP_001398229.1 2121261 D 5061 CDS An16g09320 4989323 complement(join(2122334..2122507,2122576..2124984,2125046..2125081,2125168..2125194,2125245..2125390,2125450..2125543)) V 1 NT_166531.1 Function: ALA1 of S. cerevisiae converts ATP + L-alanine + tRNA(ALA) to AMP + pyrophosphate + L-alanyl-tRNA(ALA).; Similarity: the gene model is confirmed by several A. niger ESTs.; Title: strong similarity to cytosolic alanine--tRNA ligase Ala1 - Saccharomyces cerevisiae; cytoplasm; See PMID 7761427; See PMID 8896263; See PMID 10601222; uncharacterized protein 2125543 4989323 An16g09320 Aspergillus niger uncharacterized protein XP_001398230.3 2122334 R 5061 CDS An16g09330 84593549 join(2125959..2126005,2126085..2126485,2126611..2126699,2126769..2126821,2127193..2127211) V 1 NT_166531.1 Similarity: this gene also shows weak similarity to EST an_3407 from Aspergillus niger; Title: weak similarity to hypothetical protein B5K2.180 - Neurospora crassa; uncharacterized protein 2127211 84593549 An16g09330 Aspergillus niger uncharacterized protein XP_059604950.1 2125959 D 5061 CDS An17g00010 4989350 join(789..1242,1298..2548,2606..2955) V 1 NT_166532.1 Catalytic activity: RCH(2)NH(2) + H(2)O + O(2) <=> RCHO + NH(3) + H(2)O(2).; Induction: AMO of H. polymorpha is induced when primary amines are the sole nitrogen source.; Localization: AMO of H. polymorpha is located in the peroxisomal matrix.; Remark: AMO of H. polymorpha requires copper as a cofactor.; Title: strong similarity to amine oxidase AMO -Hansenula polymorpha; See PMID 2500147; See PMID 8511963; uncharacterized protein 2955 4989350 An17g00010 Aspergillus niger uncharacterized protein XP_001398232.1 789 D 5061 CDS An17g00020 84593550 join(4214..4746,4927..5138,5321..5618,5771..5903) V 1 NT_166532.1 hypothetical protein 5903 84593550 An17g00020 Aspergillus niger hypothetical protein XP_059604951.1 4214 D 5061 CDS An17g00030 84593551 join(6404..6694,6752..6883,6915..7235) V 1 NT_166532.1 Function: RAD5 of S. cerevisiae is non-essential and functions in error-free postreplication repair where it is involved in the avoidance of non-homologous end-joining of DNA double strand breaks.; Remark: RAD5 of S. cerevisiae is also known as REV2,SNM2 and YLR032W.; Title: weak similarity to DNA repair protein Rad5 -Saccharomyces cerevisiae; See PMID 9016623; See PMID 1324406; See PMID 1394508; uncharacterized protein 7235 84593551 An17g00030 Aspergillus niger uncharacterized protein XP_059604952.1 6404 D 5061 CDS An17g00040 84593552 join(8186..8287,8441..8827) V 1 NT_166532.1 hypothetical protein 8827 84593552 An17g00040 Aspergillus niger hypothetical protein XP_059604953.1 8186 D 5061 CDS An17g00050 84593553 complement(join(8923..8997,9086..9167,9273..9332,9388..9488,9560..9580)) V 1 NT_166532.1 hypothetical protein 9580 84593553 An17g00050 Aspergillus niger hypothetical protein XP_059604954.1 8923 R 5061 CDS An17g00060 84593554 join(10955..11031,11120..11236,11309..11492,11537..11889,11932..12271) V 1 NT_166532.1 hypothetical protein 12271 84593554 An17g00060 Aspergillus niger hypothetical protein XP_059604955.1 10955 D 5061 CDS An17g00070 84593555 join(13437..13867,14151..14349) V 1 NT_166532.1 Remark: the predicted ORF contains a relatively long intron.; hypothetical protein 14349 84593555 An17g00070 Aspergillus niger hypothetical protein XP_059604956.1 13437 D 5061 CDS An17g00090 84593556 complement(join(15549..15566,15855..16421)) V 1 NT_166532.1 Title: weak similarity to translocation protein Sec72 - Saccharomyces cerevisiae; uncharacterized protein 16421 84593556 An17g00090 Aspergillus niger uncharacterized protein XP_059604957.1 15549 R 5061 CDS An17g00100 84593557 complement(join(<17744..17838,17886..18512)) V 1 NT_166532.1 Function: the transposase in the A. niger Tan1 transposable element excises the Vader element within Tan1.; Similarity: the transposase in the A. niger Tan1 transposable element shows similarity to the F. oxysporum Fot1 and M. frisea Pot2 transposases.; Title: strong similarity to transposase of Tan1 -Aspergillus niger; putative frameshift; See PMID 9003286; See PMID 10547692; uncharacterized protein 18512 84593557 An17g00100 Aspergillus niger uncharacterized protein XP_059604958.1 17744 R 5061 CDS An17g00120 4989341 complement(join(19014..19160,19221..19678,19741..20629,20700..20825)) V 1 NT_166532.1 Function: msf1 of B. cinerea acts in the protection against fungicides and is involved in multi-drug resistance development.; Similarity: msf1 of B. cinerea is a member of the major facilitator superfamily.; Title: strong similarity to major facilitator superfamily transporter protein mfs1 - Botrytis cinerea; See PMID 10955904; See PMID 11374155; uncharacterized protein 20825 4989341 An17g00120 Aspergillus niger uncharacterized protein XP_001398241.1 19014 R 5061 CDS An17g00130 4989361 join(21182..21260,21298..21305,21462..22078,22127..22389,22439..23043) V 1 NT_166532.1 Function: cercosporin is a photosensitizing perylenequinone toxin and crg1 from C. nicotianae provides direct resistance to its activity.; Title: weak similarity to cercosporin resistance protein crg1 - Cercospora nictotianae; See PMID 10517336; uncharacterized protein 23043 4989361 An17g00130 Aspergillus niger uncharacterized protein XP_059604959.1 21182 D 5061 CDS An17g00140 84593558 join(23686..24803,24869..25199,25265..>25616) V 1 NT_166532.1 Complex: lovastatin lovB is a heterodimer of a nonaketide chain and a diketide,2-methylbutyrate.; Function: lovastation lovB of A. terreus is an HMG-CoA reductase inhibitor whose nonaketide chain undergoes cyclization to a hexahydronaphthalene ring system.; Remark: the nonaketide and diketide chains are synthesized by separate large multifunctional polyketide synthases.; Similarity: An17g00140 shows similarity only to a middle section of the long (3038 amino acids) lovB sequence from A. terreus.; Title: strong similarity to lovastatin nonaketide synthase lovB - Aspergillus terreus [putative frameshift]; putative frameshift; See PMID 10381407; See PMID 11378962; uncharacterized protein 25616 84593558 An17g00140 Aspergillus niger uncharacterized protein XP_059604960.1 23686 D 5061 CDS An17g00150 4989333 join(26930..27059,27102..27260,27281..27822) V 1 NT_166532.1 Similarity: the ORF encoded protein has similarity only to the C-terminal region of M. grisea gag protein encoded within a transposon.; Title: weak similarity to protein gag - Magnaporthe grisea; uncharacterized protein 27822 4989333 An17g00150 Aspergillus niger uncharacterized protein XP_059604961.1 26930 D 5061 CDS An17g00160 84593559 28206..28502 V 1 NT_166532.1 Remark: the ORF has a short length (98 amino acids).; hypothetical protein 28502 84593559 An17g00160 Aspergillus niger hypothetical protein XP_059604962.1 28206 D 5061 CDS An17g00170 4989353 complement(join(28969..29039,29143..29287,29319..29715,29766..30118,30190..30345)) V 1 NT_166532.1 hypothetical protein 30345 4989353 An17g00170 Aspergillus niger hypothetical protein XP_059604963.1 28969 R 5061 CDS An17g00180 4989336 complement(32553..34139) V 1 NT_166532.1 hypothetical protein 34139 4989336 An17g00180 Aspergillus niger hypothetical protein XP_001398247.1 32553 R 5061 CDS An17g00190 84593560 complement(join(35338..35502,35603..35673,35801..35956,36056..36167)) V 1 NT_166532.1 hypothetical protein 36167 84593560 An17g00190 Aspergillus niger hypothetical protein XP_059604964.1 35338 R 5061 CDS An17g00200 4989331 join(36399..36452,36514..37329) V 1 NT_166532.1 Catalytic activity: S-adenosyl-L-methionine + catechol <=> S-adenosyl-L-homocysteine + guaiacol.; Complex: rat COMT exists as a monomer.; Function: catechol O-methyltransferase (COMT) has a role in the inactivation of catecholamine neurotransmitters.; Localization: in rat two forms of COMT exist, a soluble form (S-COMT) which is cytoplasmic and a membrane-bound form (MB-COMT).; Remark: in rat S-COMT and MB-COMT are encoded by the same gene but use two different promoters, P1 which is regulated in a tissue-specific manner and P2 which functions constitutively.; Title: strong similarity to catechol O-methyltransferase - Rattus norvegicus; See PMID 8672242; See PMID 9262345; See PMID 2227437; See PMID 2645868; See PMID 8280056; uncharacterized protein 37329 4989331 An17g00200 Aspergillus niger uncharacterized protein XP_001398249.3 36399 D 5061 CDS An17g00210 4989337 join(37743..38025,38094..38189,38252..38655,38725..38812,38869..39080) V 1 NT_166532.1 Remark: strong similarity to A. niger EST sequence BE759508 in EMBLEST.; Similarity: strong similarity to many hypothetical oxidoreductases predicted in many different species.; Title: strong similarity to hypothetical oxidoreductase CAB46711.1 - Schizosaccharomyces pombe; uncharacterized protein 39080 4989337 An17g00210 Aspergillus niger uncharacterized protein XP_001398250.1 37743 D 5061 CDS An17g00220 84593561 join(39401..39457,39565..39858) V 1 NT_166532.1 hypothetical protein 39858 84593561 An17g00220 Aspergillus niger hypothetical protein XP_059604965.1 39401 D 5061 CDS An17g00230 4989345 join(40071..40113,40210..40574,40643..41221) V 1 NT_166532.1 Title: similarity to hypothetical protein slr0789 -Synechocystis sp.; uncharacterized protein 41221 4989345 An17g00230 Aspergillus niger uncharacterized protein XP_001398252.1 40071 D 5061 CDS An17g00240 4989338 join(42234..42806,42872..44140) V 1 NT_166532.1 Remark: An17g00240 shows strong similarity to many A. thaliana patent EST sequences.; Remark: YER036c of S. cerevisiae is also known as KRE30.; Similarity: strong similarity to many hypothetical ABC transporter proteins in many different species.; Title: strong similarity to hypothetical protein YER036c - Saccharomyces cerevisiae; uncharacterized protein 44140 4989338 An17g00240 Aspergillus niger uncharacterized protein XP_001398253.1 42234 D 5061 CDS An17g00250 4989358 complement(join(<45177..45332,45394..45726)) V 1 NT_166532.1 Complex: CCL1 interacts with the RNA polymerase II carboxy-terminal domain kinase KIN28, so forming a component of the trancription factor TFIIH.; Function: the CCL1/KIN28 complex is involved in regulating transcription by controlling the phosphorylation of RNA polymerase II.; Remark: CCL1 from yeast is also known as YPR025C.; Remark: CCL1/KIN28 from yeast are essential for cell proliferation.; Title: similarity to cyclin Ccl1 - Saccharomyces cerevisiae; See PMID 8557668; See PMID 8761664; See PMID 10594013; See PMID 8230216; uncharacterized protein 45726 4989358 An17g00250 Aspergillus niger uncharacterized protein XP_001398254.3 45177 R 5061 CDS An17g00260 4989359 complement(join(46252..46426,46479..46783,46852..47112)) V 1 NT_166532.1 Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.; Function: UBC1 catalyzes the covalent attachment of ubiquitin to proteins primarily involved in the early stages of growth after spore germination.; Pathway: UBC1 is a component of the protein degradation pathway.; Similarity: the ORF shows strong similarity to an A. thaliana patent protein sequence AAG04759.; Title: strong similarity to ubiquitin conjugating enzyme Ubc1 - Saccharomyces cerevisiae; See PMID 940954; See PMID 1740189; See PMID 1844315; See PMID 2265617; See PMID 2561543; uncharacterized protein 47112 4989359 An17g00260 Aspergillus niger uncharacterized protein XP_001398255.1 46252 R 5061 CDS An17g00270 4989364 join(48101..48103,48182..48247,48312..49380,49430..49683) V 1 NT_166532.1 Complex: the S4 chain is a component of the 26S protease multiprotein complex.; Function: 26S protease is involved in the ATP-dependent degradation of poly-ubiquinated proteins.; Remark: 26S protease has been shown, in fission yeast, to be essential for the completion of mitosis.; Similarity: the ORF shows strong similarity to human S4 protein patent sequence and to many A. thaliana patent sequences.; Title: strong similarity to 26S ATP/ubiquitin-dependent proteinase chain S4 -Schizosaccharomyces pombe; See PMID 8247131; uncharacterized protein 49683 4989364 An17g00270 Aspergillus niger uncharacterized protein XP_001398256.1 48101 D 5061 CDS An17g00280 4989326 50092..51870 V 1 NT_166532.1 Title: strong similarity to GTPase associated protein-13 GTPAP-13 from patent WO200031263-A2 - Homo sapiens; uncharacterized protein 51870 4989326 An17g00280 Aspergillus niger uncharacterized protein XP_059606561.1 50092 D 5061 CDS An17g00290 4989329 join(52927..53213,53514..53941,54015..55513) V 1 NT_166532.1 Remark: the human homolog is significantly shorter and shows only similarity to the N-terminal half of the protein bearing a number of putative transmembrane domains.; Title: strong similarity to hypothetical protein BAB14779.1 - Homo sapiens; uncharacterized protein 55513 4989329 An17g00290 Aspergillus niger uncharacterized protein XP_059606562.1 52927 D 5061 CDS An17g00300 4989339 join(56471..56648,56755..56847,56896..57003,57063..57139,57193..57300,57357..57535,57585..57653,57707..57922,57971..58578,58658..>59438) V 1 NT_166532.1 Function: the T. ethanolicus homolog xarB encodes a bifunctional xylosidase-arabinosidase with activity against multiple substrates with the highest affinity towards p-nitrophenyl beta-D-xylopyranoside (pNPX) and highest activity against p-nitrophenyl alpha-L-arabinopyranoside (pNPAP), respectively.; Title: strong similarity to bifunctiona xylosidase-arabinosidase xarB - Thermoanaerobacter ethanolicus [putative frameshift]; putative frameshift; uncharacterized protein 59438 4989339 An17g00300 Aspergillus niger uncharacterized protein XP_059606563.1 56471 D 5061 CDS An17g00310 4989357 complement(join(59691..61394,61465..61590,61651..61674)) V 1 NT_166532.1 hypothetical protein 61674 4989357 An17g00310 Aspergillus niger hypothetical protein XP_059606564.1 59691 R 5061 CDS An17g00320 4989327 join(62753..63195,63264..65866,65918..66630) V 1 NT_166532.1 Title: strong similarity to hypothetical membrane protein YDR326c - Saccharomyces cerevisiae; uncharacterized protein 66630 4989327 An17g00320 Aspergillus niger uncharacterized protein XP_001398261.1 62753 D 5061 CDS An17g00330 4989348 complement(join(67685..68457,68515..68574,68645..69028,69088..69727)) V 1 NT_166532.1 Title: strong similarity to hypothetical protein related to ahmp1 - Neurospora crassa; uncharacterized protein 69727 4989348 An17g00330 Aspergillus niger uncharacterized protein XP_059606565.1 67685 R 5061 CDS An17g00340 4989328 complement(join(70443..70738,70793..70987,71041..71154,71205..71342,71394..71472,71531..71689)) V 1 NT_166532.1 Similarity: belongs to the fission yeast pyridoxine 4-dehydrogenase family.; Title: strong similarity to hypothetical oxidoreductase PA2535 - Pseudomonas aeruginosa; uncharacterized protein 71689 4989328 An17g00340 Aspergillus niger uncharacterized protein XP_001398263.1 70443 R 5061 CDS An17g00350 84593562 join(72813..72905,72980..73070,73162..73214,73364..73495) V 1 NT_166532.1 hypothetical protein 73495 84593562 An17g00350 Aspergillus niger hypothetical protein XP_059606566.1 72813 D 5061 CDS An17g00360 84593563 join(74082..74140,74323..74374,74429..74525,74649..74780,74859..74910,74953..75045,75130..75216,75311..75366,75458..75717) V 1 NT_166532.1 hypothetical protein 75717 84593563 An17g00360 Aspergillus niger hypothetical protein XP_059606567.1 74082 D 5061 CDS An17g00370 4989346 join(75983..76197,76478..76784,76842..77075,77126..77455) V 1 NT_166532.1 Similarity: shows strong similarity to expressed sequence tag seq id no:5420 of patent WO200056762-A2 from Aspergillus oryzae.; Title: strong similarity to hypothetical single-stranded TG1-3 binding protein tcg -Schizosaccharomyces pombe; uncharacterized protein 77455 4989346 An17g00370 Aspergillus niger uncharacterized protein XP_001398266.1 75983 D 5061 CDS An17g00380 4989352 complement(join(78892..79268,79323..79482,79844..80257)) V 1 NT_166532.1 hypothetical protein 80257 4989352 An17g00380 Aspergillus niger hypothetical protein XP_059606568.1 78892 R 5061 CDS An17g00390 4989343 complement(join(80550..80624,80675..80846,80900..81042,81108..81485,81539..81705,81756..82140)) V 1 NT_166532.1 Title: strong similarity to aminopeptidase from patent WO9628542-A1 - Aspergillus oryzae; uncharacterized protein 82140 4989343 An17g00390 Aspergillus niger uncharacterized protein XP_001398268.1 80550 R 5061 CDS An17g00400 4989344 join(83728..83769,83880..83948,84066..84809,84842..85243) V 1 NT_166532.1 Function: the S. cerevisiae homolog GCS1 encodes an ADP-ribosylation factor GTPase-activating protein (ARF GAP) that is involved in regulating retrograde vesicular transport from the Golgi to the ER, as confirmed with in vitro vesicle transport assays.; Title: strong similarity to ARF GAP zinc finger protein Gcs1 - Saccharomyces cerevisiae; cytoplasm; uncharacterized protein 85243 4989344 An17g00400 Aspergillus niger uncharacterized protein XP_059606569.1 83728 D 5061 CDS An17g00410 84593564 complement(join(85972..86110,86452..86516,86614..86712,86768..87258,87315..87667,87737..87828)) V 1 NT_166532.1 Title: strong similarity to hypothetical protein EAA64027.1 - Aspergillus nidulans; uncharacterized protein 87828 84593564 An17g00410 Aspergillus niger uncharacterized protein XP_059606570.1 85972 R 5061 CDS An17g00420 4989365 join(88633..88644,88779..89648) V 1 NT_166532.1 Title: strong similarity to hypothetical protein YBR094w - Saccharomyces cerevisiae; uncharacterized protein 89648 4989365 An17g00420 Aspergillus niger uncharacterized protein XP_059606571.1 88633 D 5061 CDS An17g00430 4989366 complement(join(90310..90503,90572..90709,91017..91050,91112..91447,91502..91862,91949..93387)) V 1 NT_166532.1 Title: similarity to hypothetical protein EAA71271.1 - Gibberella zeae; uncharacterized protein 93387 4989366 An17g00430 Aspergillus niger uncharacterized protein XP_001398272.3 90310 R 5061 CDS An17g00440 4989367 complement(join(94937..94990,95053..95185,95286..96565,96625..96693)) V 1 NT_166532.1 Catalytic activity: cytochrome P-450 enzymes catalyse the reaction, RH + reduced flavoprotein + O(2) = ROH + oxidised flavoprotein + H(2)O.; Function: avnA is involved in the conversion of averantin to averufin in the aflatoxin biosynthetic pathway in A. parasiticus.; Similarity: A. parasiticus avnA encodes a fungal cytochrome P-450-type enzyme assigned to a new P-450 gene family named CYP60A1.; Title: strong similarity to cytochrome P450 monooxygenase avnA - Aspergillus parasiticus; uncharacterized protein 96693 4989367 An17g00440 Aspergillus niger uncharacterized protein XP_001398273.3 94937 R 5061 CDS An17g00450 4989368 97942..98901 V 1 NT_166532.1 Catalytic activity: 2-trans,6-trans-farnesyl diphosphate <=> trichodiene + diphosphate.; Function: the F. poae homolog tri5 encodes a trichodiene synthase that participates in the biosynthesis of trichothecenes which are sesquiterpenoid epoxides that act as potent inhibitors of eukaryotic protein synthesis.; Title: similarity to trichodiene synthase tri5 from patent US6180366-B1 - Fusarium poae; uncharacterized protein 98901 4989368 An17g00450 Aspergillus niger uncharacterized protein XP_001398274.1 97942 D 5061 CDS An17g00460 84593565 join(99484..99517,99550..99639,99704..99802,99877..100058) V 1 NT_166532.1 hypothetical protein 100058 84593565 An17g00460 Aspergillus niger hypothetical protein XP_059606572.1 99484 D 5061 CDS An17g00470 4989370 join(100593..100629,100760..101160,101234..101911,102004..102141) V 1 NT_166532.1 Catalytic activity: ATP + a protein <=> ADP + a phosphoprotein.; Function: pkaR is the regulatory subunit of the cAMP dependent protein kinase PKA, which has a broad influence on cell morphogenesis and cell development.; Title: strong similarity to cAMP dependent protein kinase regulatory subunit pkaR - Aspergillus niger; deleted EC_number 2.7.1.37; uncharacterized protein 102141 4989370 An17g00470 Aspergillus niger uncharacterized protein XP_001398276.3 100593 D 5061 CDS An17g00480 84593566 complement(join(103077..103226,103284..103349,103817..103961,104350..104513,104595..104626,104720..104861,105209..105271,105562..105783,105901..106007,106544..106660,106855..107013,107152..107209)) V 1 NT_166532.1 hypothetical protein 107209 84593566 An17g00480 Aspergillus niger hypothetical protein XP_059606573.1 103077 R 5061 CDS An17g00490 4989372 join(107510..107851,107910..107961,108011..108104,108161..108443) V 1 NT_166532.1 Function: the N. lactamdurans homolog AAR92153 is required for cephem hydroxylation at C-7 and the transfer of the methyl group from S-adenosylmethionine in the 7-hydroxycephem intermediate of the cephamycin biosynthetic pathway. acts as a coupling protein with the C-7 hydroxycephem methyltransferase (AAR92152).; Title: similarity to C-7 hydroxycephem methyltransferase coupling protein from patent WO9529253-A1 - Nocardia lactamdurans; uncharacterized protein 108443 4989372 An17g00490 Aspergillus niger uncharacterized protein XP_001398278.3 107510 D 5061 CDS An17g00500 84593567 complement(108898..109653) V 1 NT_166532.1 hypothetical protein 109653 84593567 An17g00500 Aspergillus niger hypothetical protein XP_059606574.1 108898 R 5061 CDS An17g00510 84593568 complement(join(110939..111151,111222..111244,111371..111494,111533..111613)) V 1 NT_166532.1 hypothetical protein 111613 84593568 An17g00510 Aspergillus niger hypothetical protein XP_059606575.1 110939 R 5061 CDS An17g00520 4989375 complement(join(111923..113765,113819..114425,114547..114553)) V 1 NT_166532.1 Catalytic activity: hydrolysis of terminal,non-reducing beta-D-glucose residues with release of beta-D-glucose.; Pathway: cyanoamino acid metabolism; starch and sucrose metabolism; flavonoids, stilbene and lignin biosynthesis.; Remark: beta-glucosidases have wide specificity for beta-D-glucosides. Some examples also hydrolyse one or more of the following: beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, and beta-D-fucosides.; Similarity: belongs to the beta-glucosidases.; Title: strong similarity to beta-glucosidase precursor BGLUC - Kluyveromyces marxianus; uncharacterized protein 114553 4989375 An17g00520 Aspergillus niger uncharacterized protein XP_059606576.1 111923 R 5061 CDS An17g00530 4989376 complement(join(115486..117922,117995..118256,118305..120336)) V 1 NT_166532.1 Remark: the patent does not provide further information about the function of the protein.; Remark: the protein sequence of human beta-tubulin antigen is not complete.; Similarity: the predicted A. niger protein shows similarity to the protein sequence of human beta-tubulin antigen of patent WO200050593-A1 (AC# AAB08517), strong similarity to the hypothetical protein SPAC22F3. 14c of S. pombe and other hypothetical proteins from diverse eucaryotic species.; Title: similarity to beta-tubulin antigen from patent WO200050593-A1 - Homo sapiens; uncharacterized protein 120336 4989376 An17g00530 Aspergillus niger uncharacterized protein XP_059606577.1 115486 R 5061 CDS An17g00540 84593569 complement(join(<120586..121493,121722..122709)) V 1 NT_166532.1 Function: S. cerevisiae Rlr1 is required for LacZ RNA expression from certain plasmids. It is suppressor of the transcriptional defect of Hpr1 by overexpression. It plays a role in transcription elongation by RNA polymerase II.; Remark: C-terminally truncated ORF due to the end of contig.; Remark: alternate name for S. cerevisiae Rlr1: Tho2,YNL139C.; Title: similarity to suppressor of S.cerevisiae sin4 mutation Rlr1 - Saccharomyces cerevisiae [truncated ORF]; See PMID 10675628; uncharacterized protein 122709 84593569 An17g00540 Aspergillus niger uncharacterized protein XP_059602796.1 120586 R 5061 CDS An17g00550 4989378 complement(join(123548..124347,124418..124623,124689..124711)) V 1 NT_166532.1 Title: weak similarity to dTDP-glucose 4,6-dehydratase protein_id CAB05932.1 - Streptococcus pneumoniae; uncharacterized protein 124711 4989378 An17g00550 Aspergillus niger uncharacterized protein XP_001398284.1 123548 R 5061 CDS An17g00560 4989379 complement(join(125539..126410,126467..126920,126981..127415)) V 1 NT_166532.1 Complex: Biochemical cross-linking studies demonstrated that Vps5p and Vps17p physically interact.; Function: S. cerevisiae Vps17 is required for the sorting and delivery of a subset of soluble vacuolar hydrolases. It probably functions at an early stage of the sorting process. It is proposed that the Vps17 protein complex may participate in the intracellular trafficking ofthe Vps10-sorting receptor, as well as other later-Golgi proteins.; Remark: a splice site was detected upstream of the START codon.; Remark: alternate names for S. cerevisiae Vps17: YOR132W,Pep21.; Title: strong similarity to peripheral membrane protein required for vacuolar protein sorting Vps17 -Saccharomyces cerevisiae; intracellular transport vesicles; See PMID 9285823; See PMID 9700157; See PMID 8416961; uncharacterized protein 127415 4989379 An17g00560 Aspergillus niger uncharacterized protein XP_059602797.1 125539 R 5061 CDS An17g00570 4989380 join(127922..128318,128382..129061,129167..130675) V 1 NT_166532.1 Function: mitochondrial EF-G this catalyzes the gtp-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome.; Localization: mitochondrium.; Title: strong similarity to elongation factor EF-G -Arthrobacter sp.; localisation:mitochondrion; See PMID 10805567; uncharacterized protein 130675 4989380 An17g00570 Aspergillus niger uncharacterized protein XP_059602798.1 127922 D 5061 CDS An17g00580 4989381 complement(join(131165..131807,131878..132038,132093..132232,132302..132587)) V 1 NT_166532.1 Title: similarity to hypothetical protein T22A6.50 -Arabidopsis thaliana; uncharacterized protein 132587 4989381 An17g00580 Aspergillus niger uncharacterized protein XP_059602799.1 131165 R 5061 CDS An17g00590 4989382 join(134049..134276,134423..134449,134595..134933,134991..135045,135138..135242,135302..135582,135848..136097,136193..136851) V 1 NT_166532.1 Function: Pth11 from M. grisea is involved in surface dependent signal transduction during plant infection. Pth11 can activate appressorium differentiation in response to inductive surface cues and repress differentiation on poorly inductive surfaces.; Localization: in M. grisea, a Pth11-green fluorescent protein fusion localised to the cell membrane and vacuoles.; Remark: the filamentous ascomycete Magnaporthe grisea is the blast pathogen of many grass species,including rice.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529; uncharacterized protein 136851 4989382 An17g00590 Aspergillus niger uncharacterized protein XP_059602800.1 134049 D 5061 CDS An17g00600 4989383 join(138516..138587,138637..138857,139017..139751,139814..139951,140045..140152,140332..140344,140563..140955) V 1 NT_166532.1 Title: similarity to hypothetical protein encoded by An08g09690 - Aspergillus niger; uncharacterized protein 140955 4989383 An17g00600 Aspergillus niger uncharacterized protein XP_001398289.3 138516 D 5061 CDS An17g00610 84593570 join(142726..143358,143484..143537,143716..143935,144338..144433,144464..144606) V 1 NT_166532.1 hypothetical protein 144606 84593570 An17g00610 Aspergillus niger hypothetical protein XP_059602801.1 142726 D 5061 CDS An17g00620 4989385 complement(join(145468..146715,146767..146820)) V 1 NT_166532.1 hypothetical protein 146820 4989385 An17g00620 Aspergillus niger hypothetical protein XP_001398291.1 145468 R 5061 CDS An17g00630 4989386 complement(join(149274..150309,150367..150757,150821..150854)) V 1 NT_166532.1 Catalytic activity: Acetyl-CoA + L-homoserine <=> CoA + O-acetyl-L-homoserine.; Pathway: MetE from Aspergillus nidulans is involved in methionin metabolism.; Title: strong similarity to homoserine O-acetyltransferase metE - Aspergillus nidulans; See PMID 11406274; uncharacterized protein 150854 4989386 An17g00630 Aspergillus niger uncharacterized protein XP_001398292.1 149274 R 5061 CDS An17g00640 4989387 complement(151761..152795) V 1 NT_166532.1 Remark: the LovC protein is responsible for modulation of polyketide synthase activity in Aspergillus terreus.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994; uncharacterized protein 152795 4989387 An17g00640 Aspergillus niger uncharacterized protein XP_001398293.1 151761 R 5061 CDS An17g00650 4989388 join(153116..153249,153322..153954,154000..154218,154280..155273) V 1 NT_166532.1 Remark: Cercosporin is a photosensitizing perylenequinone toxin produced by the plant pathogenic Cercospora fungi. It generates the highly toxic singlet oxygen (1O2) upon exposure to light.; Title: similarity to cercosporin resistance protein Crg1 - Cercospora nicotianae; See PMID 10517336; uncharacterized protein 155273 4989388 An17g00650 Aspergillus niger uncharacterized protein XP_001398294.1 153116 D 5061 CDS An17g00660 4989389 complement(join(155468..155715,155793..156381,156460..156749,156820..157087)) V 1 NT_166532.1 Title: similarity to hypothetical oxidoreductase SMc01972 - Sinorhizobium meliloti; uncharacterized protein 157087 4989389 An17g00660 Aspergillus niger uncharacterized protein XP_001398295.1 155468 R 5061 CDS An17g00670 4989390 158296..160260 V 1 NT_166532.1 Title: strong similarity to hypothetical protein EAA63916.1 - Aspergillus nidulans; uncharacterized protein 160260 4989390 An17g00670 Aspergillus niger uncharacterized protein XP_001398296.1 158296 D 5061 CDS An17g00680 4989391 join(161371..161455,161495..161645,161715..162012,162070..162195,162242..162391,162446..163282) V 1 NT_166532.1 Title: strong similarity to protein fragment SEQ ID NO:17753 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 163282 4989391 An17g00680 Aspergillus niger uncharacterized protein XP_059602802.1 161371 D 5061 CDS An17g00690 4989392 complement(join(163833..163889,164020..164416,164531..164969,165032..165302)) V 1 NT_166532.1 Complex: COPS6 of M. musculus forms part of the heterooctameric COP9 complex.; Function: the COP9 complex of M. musculus presumably plays a role as a cellular regulator modulating multiple signaling pathways.; Similarity: the COP9 complex of M. musculus shares some structural features with the proteasome regulatory complex.; Title: strong similarity to COP9 subunit 6 COPS6 -Mus musculus; See PMID 9707402; uncharacterized protein 165302 4989392 An17g00690 Aspergillus niger uncharacterized protein XP_059602803.1 163833 R 5061 CDS An17g00700 4989393 165536..167485 V 1 NT_166532.1 hypothetical protein 167485 4989393 An17g00700 Aspergillus niger hypothetical protein XP_001398299.1 165536 D 5061 CDS An17g00710 4989394 join(167930..168037,168214..168487,168554..168954) V 1 NT_166532.1 hypothetical protein 168954 4989394 An17g00710 Aspergillus niger hypothetical protein XP_059602804.1 167930 D 5061 CDS An17g00720 4989395 join(169437..169592,169699..169874,169942..170040,170100..170315,170376..171615) V 1 NT_166532.1 Catalytic activity: NR1 of H. sapiens reduces cytochrome c and metabolizes the one-electron acceptors doxorubicin, menadione, and potassium ferricyanide.; Function: NR1 of H. sapiens presumably plays a role in the metabolic activation of chemicals activated by one-electron reduction.; Title: strong similarity to NADPH-dependent FMN and FAD containing oxidoreductase NR1 - Homo sapiens; cytoplasm; See PMID 10625700; uncharacterized protein 171615 4989395 An17g00720 Aspergillus niger uncharacterized protein XP_059602805.1 169437 D 5061 CDS An17g00730 4989396 join(172095..172145,172336..172996,173057..173139) V 1 NT_166532.1 Complex: ETF of P. denitrificans is a heterodimer of alpha and beta chains that binds one molecule of FAD.; Function: ETF of P. denitrificans transfers electrons from the beta-oxidation pathway and other oxidative pathways to the respiratory chain via electron-transferring-flavoprotein dehydrogenase.; Title: strong similarity to electron transfer flavoprotein beta chain ETF-beta - Paracoccus denitrificans; localisation:mitochondrion; See PMID 10642498; See PMID 1576992; See PMID 8376381; uncharacterized protein 173139 4989396 An17g00730 Aspergillus niger uncharacterized protein XP_001398302.1 172095 D 5061 CDS An17g00740 84593571 complement(join(176333..176453,176572..176838,176918..176966,177053..177147,177313..177458)) V 1 NT_166532.1 hypothetical protein 177458 84593571 An17g00740 Aspergillus niger hypothetical protein XP_059602806.1 176333 R 5061 CDS An17g00750 4989398 177544..179541 V 1 NT_166532.1 Similarity: the Sh3 domain is outside the homology region.; Title: similarity to hypothetical Sh3 domain protein YSC-like 1 - Homo sapiens; uncharacterized protein 179541 4989398 An17g00750 Aspergillus niger uncharacterized protein XP_001398304.1 177544 D 5061 CDS An17g00760 4989399 join(180349..180507,180574..180960,181018..181508,181536..182370) V 1 NT_166532.1 Catalytic activity: Peptide + H2O = hydrolyzed peptide (preferential release of a C-terminal arginine or lysine residue).; Function: carboxypeptidase S1 of P. janthinellum is a homolog of the killer factor and prohormone-processing carboxypeptidase KEX1.; Title: strong similarity to carboxypeptidase S1 -Penicillium janthinellum; See PMID 8224168; uncharacterized protein 182370 4989399 An17g00760 Aspergillus niger uncharacterized protein XP_059602807.1 180349 D 5061 CDS An17g00770 4989400 join(183127..183274,183342..184027,184081..184377) V 1 NT_166532.1 Function: DnaJ is a molecular chaperone interacting with heat shock transcription factors.; Induction: DnaJ is induced by heat shock.; Title: strong similarity to hypothetical DnaJ-like heat shock protein 17E5.120 - Neurospora crassa; uncharacterized protein 184377 4989400 An17g00770 Aspergillus niger uncharacterized protein XP_001398306.1 183127 D 5061 CDS An17g00780 4989401 join(184890..185042,185133..185345,185417..185755,185841..186647) V 1 NT_166532.1 Function: Pbn1p of S. cerevisiae is required for the autocatalytic processing of protease B precursor Prb1p in the ER.; Title: similarity to protease B processing protein Pbn1 - Saccharomyces cerevisiae; See PMID 9649520; uncharacterized protein 186647 4989401 An17g00780 Aspergillus niger uncharacterized protein XP_059602808.1 184890 D 5061 CDS An17g00790 4989402 complement(186695..188431) V 1 NT_166532.1 Similarity: contains a fungal-type Zn(2)-Cys(6) binuclear cluster DNA-binding domain.; Title: strong similarity to hypothetical transcription repressor Rdr1 - Saccharomyces cerevisiae; uncharacterized protein 188431 4989402 An17g00790 Aspergillus niger uncharacterized protein XP_001398308.1 186695 R 5061 CDS An17g00800 4989403 join(188915..188997,189045..189831,190103..190163,190209..190738) V 1 NT_166532.1 Similarity: shows some homology to the protein of the patent database entry PATENTPROT:AAY92596.; Similarity: the N-terminus shows similarity to the fungal-type Zn(2)-Cys(6) binuclear cluster DNA-binding domain.; Title: weak similarity to apoptosis associated protein #11 from patent WO200102550-A2 - Candida albicans; uncharacterized protein 190738 4989403 An17g00800 Aspergillus niger uncharacterized protein XP_059602809.1 188915 D 5061 CDS An17g00810 4989404 191074..192009 V 1 NT_166532.1 Title: strong similarity to hypothetical short chain dehydrogenase SPCC736.13 - Schizosaccharomyces pombe; uncharacterized protein 192009 4989404 An17g00810 Aspergillus niger uncharacterized protein XP_001398310.3 191074 D 5061 CDS An17g00820 4989405 194004..195365 V 1 NT_166532.1 Catalytic activity: 2 ATP + L-Gln + CO2 + H2O = 2 ADP + phosphate + L-Glu + carbamoyl phosphate.; Complex: arg2 of T. virens constitutes the small (glutamine) subunit of the dimeric enzyme.; Pathway: arg2 of T. virens is involved in arginine biosynthesis.; Similarity: contains a domain with similarity to type-1 glutamine amidotransferases.; Title: strong similarity to arginine-specific carbamoyl phosphate synthase small subunit arg2 -Trichoderma virens; See PMID 9501476; uncharacterized protein 195365 4989405 An17g00820 Aspergillus niger uncharacterized protein XP_001398311.1 194004 D 5061 CDS An17g00830 4989406 complement(195826..197574) V 1 NT_166532.1 Catalytic activity: tannic acid + H2O = gallic acid + glucose.; Complex: tannase of A. oryzae probably forms a heterooctamer.; Remark: tannase of A. oryzae is translated as a single polypeptide that is cleaved by post-translational modification into two tannase subunits linked by a disulfide bond(s).; Title: strong similarity to precursor of tannase -Aspergillus oryzae; See PMID 8917102; uncharacterized protein 197574 4989406 An17g00830 Aspergillus niger uncharacterized protein XP_001398312.1 195826 R 5061 CDS An17g00840 4989407 complement(join(198541..198748,198812..198976,199029..199086,199141..199286,199337..199446,199506..199824,199896..199920,199983..199997,200058..200086,200163..200191)) V 1 NT_166532.1 Function: DRG1 of A. thaliana is probably involved in the regulation of vesicle transport in actively growing tissues.; Localization: DRG1 of A. thaliana is localized in cytoplasmatic vesicles of actively growing tissues.; Title: strong similarity to developmentally regulated G-protein DRG1 - Arabidopsis thaliana; intracellular transport vesicles; See PMID 10380799; uncharacterized protein 200191 4989407 An17g00840 Aspergillus niger uncharacterized protein XP_001398313.1 198541 R 5061 CDS An17g00850 4989408 200535..201761 V 1 NT_166532.1 Complex: Cwf2p of S. pombe is associated with Cpc5p in a 40S RNP complex.; Function: Cwf2p of S. pombe is involved in spliceosome assembly and function.; Title: strong similarity to cdc5-associated ribonucleoprotein subunit cwf2p - Schizosaccharomyces pombe; See PMID 10409726; uncharacterized protein 201761 4989408 An17g00850 Aspergillus niger uncharacterized protein XP_001398314.1 200535 D 5061 CDS An17g00860 4989409 complement(join(201984..202291,202344..202785,202837..204270,204320..204649,204705..206750,206809..207027)) V 1 NT_166532.1 Catalytic activity: Gcn2p of S. cerevisiae transfers phosphate moieties from ATP to serine/threonine residues of eIF2 alpha.; Function: Gcn2p of S. cerevisiae increases the translation of GCN4, a transcriptional activator of amino-acid biosynthesis genes.; Function: the C-terminal histidyl-tRNA synthetase-like domain of Gcn2p of S. cerevisiae presumably responds to the presence of uncharged tRNA(His) by activating the adjacent protein kinase moiety.; Induction: Gcn2p of S. cerevisiae is transcriptionally activated by Gcn4p, thereby creating a self-enhancing circuit of amino-acid biosynthesis activation under amino-acid starvation conditions.; Similarity: Gcn2p of S. cerevisiae contains a C-terminal domain homologous to histidyl-tRNA synthetase.; Title: strong similarity to eIF2-alpha specific protein kinase Gcn2 - Saccharomyces cerevisiae; See PMID 660141; See PMID 3290651; uncharacterized protein 207027 4989409 An17g00860 Aspergillus niger uncharacterized protein XP_001398315.1 201984 R 5061 CDS An17g00870 4989410 join(207537..207576,207788..>209661) V 1 NT_166532.1 Remark: the ORF is C-terminally truncated due to end of contig.; Title: similarity to hypothetical transcription regulator AAB94013.1 - Sorghum bicolor [truncated ORF]; See PMID 9475753; uncharacterized protein 209661 4989410 An17g00870 Aspergillus niger uncharacterized protein XP_001398316.3 207537 D 5061 CDS An17g00880 4989411 complement(join(210262..210492,210551..211404,211458..211570,211634..211764,211827..211949)) V 1 NT_166532.1 Remark: the patent does not provide further information about the function of the protein.; Remark: this invention describes novel human nucleic acid (cDNA) sequences (A), that are highly expressed in uterine tumour tissue and which have anticancer and cytostatic activity.; Similarity: the predicted A. niger protein shows strong similarity to human endometrium tumour EST encoded protein 137 of patent DE19817948-A1 and many conserved hypothetical proteins.; Title: strong similarity to endometrium tumour EST encoded protein 137 from patent DE19817948-A1 - Homo sapiens; uncharacterized protein 211949 4989411 An17g00880 Aspergillus niger uncharacterized protein XP_001398317.3 210262 R 5061 CDS An17g00890 4989412 complement(join(212613..212651,212705..213871,213939..214019,214090..214242)) V 1 NT_166532.1 Function: when expressed in E. coli, the catalytic domain of PPT of R. norvegicus exhibited protein phosphatase activity (dephosphorylation of phosphorylase a) that was inhibitable by okadaic acid.; Similarity: the predicted A. niger protein shows strong similarity to phosphoprotein phosphatase (PPT) of R. norvegicus, which belongs to the fourth subfamily of the PPP-family of protein phosphatases, which includes PP1,PP2A and PP2B (calcineurin).; Title: strong similarity to phosphoprotein phosphatase PPT - Rattus norvegicus; nucleus; See PMID 8077208; uncharacterized protein 214242 4989412 An17g00890 Aspergillus niger uncharacterized protein XP_001398318.1 212613 R 5061 CDS An17g00900 4989413 join(214669..214746,214832..215056) V 1 NT_166532.1 Cofactor: SPT4 of S. cerevisiae requires metal binding for its function.; Complex: SPT4 and SPT5 form a complex that does not contain SPT6.; Function: SPT4 of S. cerevisiae is involved in chromatin structure that influences expression of many genes.; Function: SPT4 of S. cerevisiae is involved in transcription elongation.; Function: SPT4 of S. cerevisiae is involved in transcription-coupled repair (TCR). in yeast, the Rad26 protein is implicated specifically in TCR. deletion of the SPT4 gene suppresses the rad26 defect.; Function: SPT4 of S. cerevisiae plays a role in chromosome segregation as it is important for kinetochore function, but not as a structural component of the centromere (CEN) DNA-protein complex.; Remark: some of the cysteine residues are essential to yeast Spt4p function.; Similarity: the predicted A. niger protein shows strong similarity to SPT4 of S. cerevisiae, which belongs to the zinc finger transcriptional regulators.; Title: strong similarity to protein Spt4 -Saccharomyces cerevisiae; nucleus; See PMID 8483459; See PMID 8649393; See PMID 11101522; uncharacterized protein 215056 4989413 An17g00900 Aspergillus niger uncharacterized protein XP_001398319.3 214669 D 5061 CDS An17g00910 4989414 complement(join(215758..215804,215857..217019,217095..217130,217200..217450)) V 1 NT_166532.1 Catalytic activity: 4-aminobutyrate aminotransferase from A. nidulans catalyses the reaction 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.; Cofactor: 4-aminobutyrate aminotransferase from A. nidulans needs pyridoxal phosphate as a cofactor.; Induction: 4-aminobutyrate aminotransferase from A. nidulans is under positive control by the regulatory gene amdR (also called intA).; Pathway: 4-aminobutyrate aminotransferase from A. nidulans is involved in the metabolism of glutamate,aspartate, alanine, beta-alanine, propanoate and butanoate.; Similarity: the predicted A. niger protein shows strong similarity to 4-aminobutyrate aminotransferase from A. nidulans and many other organisms.; Title: strong similarity to 4-aminobutyrate transaminase gatA - Aspergillus nidulans; cytoplasm; See PMID 2505051; uncharacterized protein 217450 4989414 An17g00910 Aspergillus niger uncharacterized protein XP_001398320.1 215758 R 5061 CDS An17g00920 84593572 complement(join(217917..218131,218290..218379,218662..218762,219121..219245)) V 1 NT_166532.1 hypothetical protein 219245 84593572 An17g00920 Aspergillus niger hypothetical protein XP_059605694.1 217917 R 5061 CDS An17g00930 4989416 join(219407..219711,219794..219901,219949..220117,220183..220368) V 1 NT_166532.1 Remark: during fruiting body development, the product of the csgA gene is necessary for cellular aggregation, for spore differentiation, and for gene expression that is initiated after 6 hr of starvation. C-factor of M. xanthus is active over a narrow range of concentration and has properties of a morphogenetic paracrine signal.; Similarity: the predicted A. niger protein shows similarity to the C-factor of M. xanthus, to 17 beta-hydroxysteroid dehydrogenases of vertebrates and many hypothetical proteins of diverse organisms, that belong to the short-chain dehydrogenases/reductases family (SDR) by similarity.; Title: similarity to developmental protein C-factor csgA - Myxococcus xanthus; See PMID 1668187; See PMID 2107980; See PMID 2152896; uncharacterized protein 220368 4989416 An17g00930 Aspergillus niger uncharacterized protein XP_059605695.1 219407 D 5061 CDS An17g00940 4989417 complement(join(223189..223629,223682..224006,224064..224368,224424..224624)) V 1 NT_166532.1 Function: PTH11 of M. grisea is required for appressorium differentiation in response to inductive surface cues.; Function: as do most fungal plant pathogens, M. grisea differentiates an infection structure specialized for host penetration called the appressorium.; Phenotype: M. grisea cells null mutant for PTH11 are no more pathogenic.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529; uncharacterized protein 224624 4989417 An17g00940 Aspergillus niger uncharacterized protein XP_001398323.1 223189 R 5061 CDS An17g00950 84593573 join(225020..225379,225457..225810,225942..226202) V 1 NT_166532.1 hypothetical protein 226202 84593573 An17g00950 Aspergillus niger hypothetical protein XP_059605696.1 225020 D 5061 CDS An17g00960 84593574 complement(join(226635..226692,226751..226768,226951..227165)) V 1 NT_166532.1 hypothetical protein 227165 84593574 An17g00960 Aspergillus niger hypothetical protein XP_059605697.1 226635 R 5061 CDS An17g00970 4989420 join(230588..230947,231000..231054,231107..231898,231962..232180,232250..232275) V 1 NT_166532.1 Similarity: the predicted ORF shows similarity to several hypothetical and known aldehyde dehydrogenases with different substrate specificity.; Title: strong similarity to betaine aldehyde dehydrogenase - Avicennia marina; See PMID 11292080; uncharacterized protein 232275 4989420 An17g00970 Aspergillus niger uncharacterized protein XP_001398326.3 230588 D 5061 CDS An17g00980 84593575 complement(join(233405..233561,233905..234020)) V 1 NT_166532.1 hypothetical protein 234020 84593575 An17g00980 Aspergillus niger hypothetical protein XP_059605698.1 233405 R 5061 CDS An17g00990 84593576 complement(join(234090..234203,234294..234383,234478..234552)) V 1 NT_166532.1 hypothetical protein 234552 84593576 An17g00990 Aspergillus niger hypothetical protein XP_059605699.1 234090 R 5061 CDS An17g01000 4989423 join(234897..235100,235162..235309,235362..235446,235495..235620,235670..235734,235846..236019,236073..236246,236298..236644) V 1 NT_166532.1 Title: strong similarity to hypothetical protein sll1024 - Synechocystis sp.; uncharacterized protein 236644 4989423 An17g01000 Aspergillus niger uncharacterized protein XP_059605700.1 234897 D 5061 CDS An17g01010 4989424 complement(join(237060..237125,237256..237580,237656..237774)) V 1 NT_166532.1 hypothetical protein 237774 4989424 An17g01010 Aspergillus niger hypothetical protein XP_001398330.3 237060 R 5061 CDS An17g01020 4989425 complement(join(238084..238242,238327..238548)) V 1 NT_166532.1 Remark: the human patented protein is a polypeptide encoded by one of a large number of 5' ESTs derived from mRNAs encoding secreted proteins.; Title: similarity to secreted protein SEQ ID NO:5560 from patent EP1033401-A2 - Homo sapiens; uncharacterized protein 238548 4989425 An17g01020 Aspergillus niger uncharacterized protein XP_001398331.1 238084 R 5061 CDS An17g01030 84593577 complement(join(239084..239128,239260..239472,239658..239723,239812..239898)) V 1 NT_166532.1 hypothetical protein 239898 84593577 An17g01030 Aspergillus niger hypothetical protein XP_059605701.1 239084 R 5061 CDS An17g01040 4989427 join(240031..240097,240144..241543) V 1 NT_166532.1 hypothetical protein 241543 4989427 An17g01040 Aspergillus niger hypothetical protein XP_001398333.1 240031 D 5061 CDS An17g01050 4989428 242697..247973 V 1 NT_166532.1 Function: RAD54 of S. cerevisiae is a DNA-dependent ATPase required for X-ray damage repair, mitotic recombination, and full meiotic recombination.; Similarity: the N-terminal half of the predicted protein shows no similarity with described genes.; Title: similarity to DNA-dependent ATPase Rad54 -Saccharomyces cerevisiae; nucleus; See PMID 9409819; See PMID 9409820; See PMID 9450758; See PMID 9509573; uncharacterized protein 247973 4989428 An17g01050 Aspergillus niger uncharacterized protein XP_001398334.3 242697 D 5061 CDS An17g01060 4989429 complement(join(248680..249655,249702..250931,251142..251563)) V 1 NT_166532.1 Similarity: mouse P113 is highly homologous to human HIP116, a putative transcription factor interacting with HIV LTR sequences; both show similarity to yeast SNF2/SWI2.; Similarity: the predicted protein shows similarity to different known and putative transcription factors,especially hypothetical proteins of A. thaliana; all are characterized by the presence of several functional domains found in DNA-interacting regulatory proteins, like SNF2 domains, Zn finger domains and helicase domains.; Title: strong similarity to transcription factor P113 - Mus musculus; See PMID 9427542; uncharacterized protein 251563 4989429 An17g01060 Aspergillus niger uncharacterized protein XP_059605702.1 248680 R 5061 CDS An17g01070 4989430 complement(<251938..253774) V 1 NT_166532.1 Function: FLU1 of C. albicans confers resistance to fluconazole and cycloheximide to a S. cerevisiae strain hypersensitive to multiple drugs.; Function: multidrug transporters are membrane proteins which, by an unknown mechanism, recognize diverse toxic compounds and efflux them from cells.; Remark: a putative sequencing error results in an frameshift.; Similarity: the predicted ORF shows strong similarity to known and hypothetical members of the multidrug efflux transporters belonging to the major facilitator superfamily of transport proteins.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans [putative frameshift]; putative frameshift; See PMID 8987357; See PMID 11065353; uncharacterized protein 253774 4989430 An17g01070 Aspergillus niger uncharacterized protein XP_059605703.1 251938 R 5061 CDS An17g01080 4989431 join(254887..255141,255598..257124,257337..257360) V 1 NT_166532.1 Function: F. sporotrichioides TRI7 is required for acetylation of the oxygen on C-4 of the trichotecene T-2 toxin.; Title: weak similarity to member of the trichothecene gene cluster TRI7 - Fusarium sporotrichioides; See PMID 11352533; uncharacterized protein 257360 4989431 An17g01080 Aspergillus niger uncharacterized protein XP_001398337.3 254887 D 5061 CDS An17g01090 4989432 complement(join(257604..259622,259684..260022)) V 1 NT_166532.1 Title: similarity to hypothetical protein SPCC4G3.18 - Schizosaccharomyces pombe; uncharacterized protein 260022 4989432 An17g01090 Aspergillus niger uncharacterized protein XP_001398338.1 257604 R 5061 CDS An17g01100 4989433 join(260346..260351,260473..260596,260665..260991,261044..261660,261716..264085) V 1 NT_166532.1 Similarity: the 3' region of the predicted ORF overlaps with a short fragment of A. niger EST EMBLEST:ANI239805, which probably reprents the 3' UTR of the previous An17g01110, transcribed on the other strand.; Title: similarity to hypothetical protein SPAC637.04 - Schizosaccharomyces pombe; uncharacterized protein 264085 4989433 An17g01100 Aspergillus niger uncharacterized protein XP_001398339.1 260346 D 5061 CDS An17g01110 4989434 complement(join(264327..264375,264428..264565,264616..264679,264728..264808,264863..264953)) V 1 NT_166532.1 Catalytic activity: NADH + ubiquinone = NAD+ + ubiquinol.; Function: complex I transfers electrons from NADH to the respiratory chain; the immediate electron acceptor for the enzyme is believed to be ubiquinone.; Localization: mitochondrial inner membrane; matrix side.; Similarity: the ORF shows similarity to uncharacterized differentiation-associated proteins from H. sapiens.; Similarity: the predicted protein is similar to a novel 17. 2-kDa subunit identified recently by electrospray mass spectrometry.; Similarity: to A. niger ESTs an_1032 and EST SEQ ID NO:4019.; Title: strong similarity to 17.2 kD subunit of NADH:ubiquinone reductase b17.2 - Bos taurus; localisation:mitochondrion; See PMID 9827566; uncharacterized protein 264953 4989434 An17g01110 Aspergillus niger uncharacterized protein XP_059605704.1 264327 R 5061 CDS An17g01120 4989435 join(265122..265233,265404..265603,265671..266023,266073..267015,267159..267212) V 1 NT_166532.1 Catalytic activity: phosphatidylglycerophosphate synthase, officially called CDPdiacylglycerol--serine O-phosphatidyltransferase, catalyzes the reaction: CDPdiacylglycerol + L-Serine = CMP + 3-O-sn-Phosphatidyl-L-serine.; Function: PGS1 of S. cerevisiae functions as the committed and rate-limiting step in the biosynthesis of cardiolipin (CL); in eukaryotic cells, CL is found predominantly in the inner mitochondrial membrane and is generally thought to be an essential component of many mitochondrial functions.; Function: PGS1 of S. cerevisiae is also involved in in mitochondrial-mediated control of cell multiplication.; Remark: PGS1 of S. cerevisiae is also called PEL1,YCL003W or YCL004W.; Title: strong similarity to phosphatidylglycerophosphate synthase Pgs1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8252640; See PMID 8553693; See PMID 8666200; See PMID 9335584; See PMID 9545322; uncharacterized protein 267212 4989435 An17g01120 Aspergillus niger uncharacterized protein XP_001398341.3 265122 D 5061 CDS An17g01130 4989436 complement(join(267421..268879,268940..268962)) V 1 NT_166532.1 Similarity: B7A16. 140 of N. crassa and the predicted protein are similar to S. cerevisiae LTV1, a poorly characterized protein claimed to be involved in low-temperature viability.; Title: strong similarity to hypothetical protein B7A16.140 - Neurospora crassa; uncharacterized protein 268962 4989436 An17g01130 Aspergillus niger uncharacterized protein XP_001398342.1 267421 R 5061 CDS An17g01140 4989437 269437..271431 V 1 NT_166532.1 Similarity: B7A16. 130 of N. crassa and the predicted protein show similarity to a GTPase of unknown function, human HSR1, that has been localized to the human MHC class I region and is highly homologous to a putative GTP-binding protein, MMR1 from mouse; these proteins represent a new subfamily of GTP-binding proteins that has both prokaryote and eukaryote members.; Similarity: strong similarity also to A. oryzae EST SEQ ID NO:4542 of patent WO200056762-A2.; Title: strong similarity to hypothetical conserved protein B7A16.130 - Neurospora crassa; See PMID 8180467; uncharacterized protein 271431 4989437 An17g01140 Aspergillus niger uncharacterized protein XP_001398343.1 269437 D 5061 CDS An17g01150 4989438 complement(join(271756..272562,272662..273120,273212..273286)) V 1 NT_166532.1 Remark: manual BLASTP homologue PIR:DERTCM.; Title: strong similarity to acyl-CoA dehydrogenase MCAD - Rattus norvegicus; See PMID 2029527; uncharacterized protein 273286 4989438 An17g01150 Aspergillus niger uncharacterized protein XP_001398344.1 271756 R 5061 CDS An17g01160 4989439 complement(join(273817..273907,273972..274061,274122..274270)) V 1 NT_166532.1 Function: in S. cerevisiae BNS1 (Bypasses Need for Spo12p), which has homology to SPO12, and SPO13, can partially suppress the meiotic defect of spo12 mutants when overexpressed.; Remark: BNS1 of S. cerevisiae is also called YGR230w.; Remark: in S. cerevisiae the SPO12 gene regulates meiotic nuclear division; when sporulated, spo12 mutants undergo a single meiotic nuclear division most closely resembling meiosis II.; Title: similarity to protein Bypasses Need for Spo12p Bns1 - Saccharomyces cerevisiae; See PMID 10564265; uncharacterized protein 274270 4989439 An17g01160 Aspergillus niger uncharacterized protein XP_001398345.1 273817 R 5061 CDS An17g01170 4989440 complement(274893..277382) V 1 NT_166532.1 Similarity: the predicted protein shows strong similarity also to the human breast cancer gene CH1-9a11-2 of patent WO9738085-A2.; Title: strong similarity to hypothetical membrane protein YOR154w - Saccharomyces cerevisiae; uncharacterized protein 277382 4989440 An17g01170 Aspergillus niger uncharacterized protein XP_001398346.1 274893 R 5061 CDS An17g01180 4989441 complement(278868..280802) V 1 NT_166532.1 Similarity: the predicted protein shows similarity to several putative and known protein Ser/Thr kinases with different specificity.; Title: similarity to Ser/Thr protein kinase Ksp1 -Saccharomyces cerevisiae; nucleus; See PMID 8676864; See PMID 9020587; uncharacterized protein 280802 4989441 An17g01180 Aspergillus niger uncharacterized protein XP_001398347.1 278868 R 5061 CDS An17g01190 84593578 join(281273..281313,281419..281458,281567..281640,281726..281855,282005..>282136) V 1 NT_166532.1 Remark: C-terminally truncated ORF due to contig border.; Title: questionable ORF [truncated ORF]; uncharacterized protein 282136 84593578 An17g01190 Aspergillus niger uncharacterized protein XP_059605705.1 281273 D 5061 CDS An17g01200 84593579 join(<282237..282245,282270..282538,282580..282640) V 1 NT_166532.1 Remark: the ORF is truncated and contains no start codon, due to the end of the contig.; Title: weak similarity to secreted protein gu534_1 from patent WO9846757-A2 - Homo sapiens [truncated ORF]; uncharacterized protein 282640 84593579 An17g01200 Aspergillus niger uncharacterized protein XP_059602810.1 282237 D 5061 CDS An17g01210 84593580 complement(join(283048..283162,283365..283410,283565..283625,283967..284029,284109..284183)) V 1 NT_166532.1 hypothetical protein 284183 84593580 An17g01210 Aspergillus niger hypothetical protein XP_059602811.1 283048 R 5061 CDS An17g01220 84593581 join(284591..284698,284919..284943,285021..285244) V 1 NT_166532.1 hypothetical protein 285244 84593581 An17g01220 Aspergillus niger hypothetical protein XP_059602812.1 284591 D 5061 CDS An17g01230 84593582 join(285653..285838,285886..285948,286071..286199,286359..286415,286617..286892) V 1 NT_166532.1 Title: weak similarity to polyketide synthase module 7 encoded by nidA5 - Streptomyces caelestis; uncharacterized protein 286892 84593582 An17g01230 Aspergillus niger uncharacterized protein XP_059602813.1 285653 D 5061 CDS An17g01240 84593583 complement(288541..288867) V 1 NT_166532.1 hypothetical protein 288867 84593583 An17g01240 Aspergillus niger hypothetical protein XP_059602814.1 288541 R 5061 CDS An17g01250 4989448 complement(join(289514..289598,289652..292247,292320..292536)) V 1 NT_166532.1 Function: human Vps18 is necessary for the delivery of endocytic and biosynthetic cargo in H. sapiens.; Remark: Vps18 is a human homologue of yeast Class C VPS genes.; Remark: human Vps18 is ubiquitously expressed in peripheral tissues.; Similarity: Vps proteins are predominantly associated with late endosomes/lysosomes.; Similarity: the ORF encoded protein shows also strong similarity to the undescribed DigA protein from A. nidulans.; Title: strong similarity to vacuolar protein sorting protein 18 VPS18 - Homo sapiens; endosome; See PMID 11382755; uncharacterized protein 292536 4989448 An17g01250 Aspergillus niger uncharacterized protein XP_001398354.1 289514 R 5061 CDS An17g01260 4989449 complement(join(293066..294216,294266..294872,294946..295320,295353..295460,295517..295573)) V 1 NT_166532.1 Title: strong similarity to hypothetical protein CAD21401.1 - Neurospora crassa; uncharacterized protein 295573 4989449 An17g01260 Aspergillus niger uncharacterized protein XP_059602815.1 293066 R 5061 CDS An17g01270 4989450 join(296278..296525,296619..297311,297409..297532) V 1 NT_166532.1 Similarity: a N. crassa hypothetical gene shows a much stronger similarity to the predicted protein,involving also the N-terminus.; Similarity: the predicted ORF is longer than MRPL7 of S. cerevisiae, the similarity involving only the C-terminal part.; Title: strong similarity to mitochodrial ribosomal protein of the large subunit Mrpl7 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9151978; See PMID 9445368; mitochondrial 54S ribosomal protein uL5m 297532 4989450 An17g01270 Aspergillus niger mitochondrial 54S ribosomal protein uL5m XP_001398356.1 296278 D 5061 CDS An17g01280 4989451 complement(join(298369..300672,300724..300881,300937..301010,301070..301251)) V 1 NT_166532.1 Function: nrc-1 of N. crassa is a MAPKK kinase that functions to repress the onset of conidiation.; Similarity: nrc-1 of N. crassa is closely related to the S. cerevisiae STE11 and Schizosaccharomyces pombe byr2 genes, bothe encoding MAPKK kinases necessary for sexual development in these organisms.; Similarity: the N-terminal part of the predicted protein show similarity to other protein kinases.; Title: strong similarity to MAPKK kinase nrc-1 -Neurospora crassa; See PMID 9584090; uncharacterized protein 301251 4989451 An17g01280 Aspergillus niger uncharacterized protein XP_059602816.1 298369 R 5061 CDS An17g01290 84593584 complement(join(302426..302607,302676..302718,302984..303045,303420..303534)) V 1 NT_166532.1 Title: questionable ORF; uncharacterized protein 303534 84593584 An17g01290 Aspergillus niger uncharacterized protein XP_059602817.1 302426 R 5061 CDS An17g01300 4989453 join(304746..304878,304953..305007,305070..307515) V 1 NT_166532.1 Function: the AmdA transcriptional activator from E. nidulans is involved in the induction of the E. nidulans structual gene amdS (acetamidase).; Title: strong similarity to zinc-finger transcription factor amdA - Aspergillus nidulans; nucleus; See PMID 7596297; See PMID 9126617; uncharacterized protein 307515 4989453 An17g01300 Aspergillus niger uncharacterized protein XP_001398359.1 304746 D 5061 CDS An17g01310 4989454 complement(join(308139..308462,308522..308611,308682..309023)) V 1 NT_166532.1 Similarity: the protein contains two classical Zinc finger domains, and shows local weak similarity to poorly characterized mammalian Zinc finger proteins.; Title: similarity to hypothetical protein MUA22.14 -Arabidopsis thaliana; uncharacterized protein 309023 4989454 An17g01310 Aspergillus niger uncharacterized protein XP_001398360.1 308139 R 5061 CDS An17g01320 4989455 join(310381..310528,310642..310709,310778..310955,311020..311610,311665..312215,312277..313311) V 1 NT_166532.1 Title: similarity to in E2Fa/Dpa expressing plants upregulated protein SEQ ID NO 1278 from patent WO2004035798-A2 - Arabidopsis thaliana; uncharacterized protein 313311 4989455 An17g01320 Aspergillus niger uncharacterized protein XP_059602818.1 310381 D 5061 CDS An17g01330 4989456 complement(join(314409..314454,314531..314644,314706..315043,315101..315442,315513..315666,315738..315753,315860..315911)) V 1 NT_166532.1 Catalytic activity: adenosine kinase is a very conserved enzyme catalyzing the reaction ATP + Adenosine = ADP + AMP.; Pathway: Purine metabolism.; Title: strong similarity to adenosine kinase -Cricetulus griseus; See PMID 10606765; See PMID 10964675; uncharacterized protein 315911 4989456 An17g01330 Aspergillus niger uncharacterized protein XP_001398362.1 314409 R 5061 CDS An17g01340 4989457 join(316287..316598,316691..316885,317053..317091) V 1 NT_166532.1 Title: similarity to hypothetical protein SPAC14C4.01c - Schizosaccharomyces pombe; uncharacterized protein 317091 4989457 An17g01340 Aspergillus niger uncharacterized protein XP_059602819.1 316287 D 5061 CDS An17g01350 4989458 complement(join(317728..318555,318609..318977,319035..319164,319292..319461,319566..319766)) V 1 NT_166532.1 Title: strong similarity to hypothetical protein EAA63847.1 - Aspergillus nidulans; uncharacterized protein 319766 4989458 An17g01350 Aspergillus niger uncharacterized protein XP_001398364.3 317728 R 5061 CDS An17g01360 4989459 join(321250..321298,321382..321873,321966..322051,322114..322251) V 1 NT_166532.1 Similarity: strong similarity to S. cerevisiae L8. e ribosomal protein means about 80% identity.; Similarity: two A. niger ESTs confirm the gene prediction.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L8.e Pl2b - Saccharomyces cerevisiae; cytoplasm; See PMID 9396790; See PMID 9421530; See PMID 9559554; See PMID 3327609; 60S ribosomal protein uL2 322251 4989459 An17g01360 Aspergillus niger 60S ribosomal protein uL2 XP_001398365.1 321250 D 5061 CDS An17g01370 4989460 join(323293..323590,323657..324114) V 1 NT_166532.1 Function: the E. coli Ada protein repairs O6-methylguanine residues and methyl phosphotriesters in DNA by direct transfer of the methyl group to a cysteine residue located in its C- or N-terminal domain,respectively; it is the main agent of the adaptive response of bacteria to alkylating agents.; Function: the previous remark could be of crucial importance in the assessment of the function of the predicted protein, which completely lacks similarity to the C-terminal transferase domain of Ada.; Remark: Ada of E. coli is a bifunctional protein: the O6-methylguanine transferase activity resides in the C-terminal part of the protein; methyl transfer to the N-terminal domain causes it to acquire a sequence-specific DNA binding activity, which directs binding to the regulatory region of several methylation-resistance genes.; Similarity: the similarity of the predicted protein to Ada of E. coli involves only the N-terminal half of both proteins.; Title: similarity to adaptive response regulatory protein Ada - Escherichia coli; See PMID 3529081; See PMID 3887409; See PMID 2982792; See PMID 2987251; See PMID 3009022; uncharacterized protein 324114 4989460 An17g01370 Aspergillus niger uncharacterized protein XP_001398366.1 323293 D 5061 CDS An17g01380 84593585 complement(join(325001..325120,325369..325474,325645..325692,325802..325938,326103..326213,326381..326645,326787..326849,326925..326950)) V 1 NT_166532.1 hypothetical protein 326950 84593585 An17g01380 Aspergillus niger hypothetical protein XP_059602820.1 325001 R 5061 CDS An17g01390 4989462 join(327171..327297,327365..327532,327590..327705,327767..328047,328100..328703) V 1 NT_166532.1 Similarity: AAK56937. 1 of C. immitis and the predicted protein are similar to different proteins containing SH3 domains; the domain structure is not well conserved in the predicted protein.; Similarity: althoughl AAK56937. 1 of C. immitis is much shorter than the predicted protein, the two molecules are 75% identitical in the corresponding region.; Similarity: the predicted protein show similarity in particular to the EEN gene family, a group of mammalian proteins expressed in the brain and perhaps involved in vesicular trafficking; the members of this family are nevertheless very poorly characterized in terms of function.; Title: strong similarity to hypothetical SH3 domain-containing protein AAK56937.1 - Coccidioides immitis; See PMID 9122235; See PMID 10764144; See PMID 10816441; uncharacterized protein 328703 4989462 An17g01390 Aspergillus niger uncharacterized protein XP_059602821.1 327171 D 5061 CDS An17g01400 84593586 complement(join(329156..329391,329534..329648)) V 1 NT_166532.1 hypothetical protein 329648 84593586 An17g01400 Aspergillus niger hypothetical protein XP_059602822.1 329156 R 5061 CDS An17g01410 4989464 join(329826..329918,330059..330278,330349..334064,334118..334345) V 1 NT_166532.1 Complex: SNF2 of S. cerevisiae is a component of the SWI/SNF global transcription activator complex.; Function: SNF2 of S. cerevisiae acts to assist gene-specific activators and has an effect on chromatin structure.; Remark: SNF2 of S. cerevisiae is also called SWI2,GAM1, TYE3, HAF1, RIC1 or YOR290c.; Title: strong similarity to transcription regulator Snf2 - Saccharomyces cerevisiae; nucleus; See PMID 7623818; See PMID 8871545; See PMID 8939065; See PMID 1886612; See PMID 1901413; uncharacterized protein 334345 4989464 An17g01410 Aspergillus niger uncharacterized protein XP_059602823.1 329826 D 5061 CDS An17g01420 4989465 join(336539..336592,336862..337068,337143..337151,337281..337344,337418..337475,337554..337671) V 1 NT_166532.1 Similarity: the predicted protein shows similarity to human genes of unclear function genetically linked to familial adenomatous polyposis.; Title: strong similarity to hypothetical transport protein SPCC830.08c - Schizosaccharomyces pombe; uncharacterized protein 337671 4989465 An17g01420 Aspergillus niger uncharacterized protein XP_001398371.1 336539 D 5061 CDS An17g01430 4989466 complement(join(338651..338838,338935..339273,339355..339433)) V 1 NT_166532.1 Remark: the A. thaliana homologue, as the vast majority of A. thaliana transcripts, has been patented under patentnumber EP1033405-A2.; Title: similarity to hypothetical protein MUD21.19 -Arabidopsis thaliana; uncharacterized protein 339433 4989466 An17g01430 Aspergillus niger uncharacterized protein XP_001398372.1 338651 R 5061 CDS An17g01440 4989467 join(340474..340631,340728..341080,341142..341538,341599..342292) V 1 NT_166532.1 Function: Pex3 of P. angusta is involved in peroxisome biosynthesis.; Localization: Pex3 of P. angusta is an integral peroxisomal membrane protein.; Title: strong similarity to peroxisomal membrane protein PEX3 - Pichia angusta; peroxisome; See PMID 8621531; uncharacterized protein 342292 4989467 An17g01440 Aspergillus niger uncharacterized protein XP_001398373.1 340474 D 5061 CDS An17g01450 4989468 join(343258..343433,343518..343525,343958..344126,344204..344352,344459..344584,344642..344998,345099..345114,345164..345225,345276..345593,345654..345898) V 1 NT_166532.1 Remark: TNA1 is necessary for nicotinic acid import into the cell.; Remark: TNA1 of S. cerevisiae is also called YGR260w.; Similarity: belongs to the allantoate permease family; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563; See PMID 10984621; uncharacterized protein 345898 4989468 An17g01450 Aspergillus niger uncharacterized protein XP_059602824.1 343258 D 5061 CDS An17g01460 84593587 join(346687..346795,346879..346916,346945..347151) V 1 NT_166532.1 Title: strong similarity to EST SEQ ID NO:4056 from patent WO200056762-A2 - Aspergillus niger; uncharacterized protein 347151 84593587 An17g01460 Aspergillus niger uncharacterized protein XP_059602825.1 346687 D 5061 CDS An17g01470 4989470 join(347422..347569,347657..347988,348056..349057) V 1 NT_166532.1 Catalytic activity: n nucleoside triphosphate = n pyrophosphate + RNA(n).; Complex: RNA polymerase I consists of 14 different subunits.; Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. RNA polymerase A (I) is essentially used to transcribe ribosomal DNA units.; Function: RPA49 is easily dissociated from the rest of Pol A, producing the form A*, which shows impaired transcriptional activity and increased sensitivity to alpha-amanitin. The function of A49 might be linked to the RNAse H activity that was found associated with this subunit.; Title: similarity to 49 kD subunit of DNA-directed RNA polymerase I Rpa49 - Saccharomyces cerevisiae; nucleus; See PMID 1409638; uncharacterized protein 349057 4989470 An17g01470 Aspergillus niger uncharacterized protein XP_001398376.1 347422 D 5061 CDS An17g01480 4989471 complement(join(350750..352353,352427..352772)) V 1 NT_166532.1 Catalytic activity: succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.; Pathway: glycine, serine and threonine metabolism.; Remark: also strong similarity to 5-aminolevulinic acid synthase from Aspergillus oryzae patent WO9747746-A1.; Remark: hemA of E. nidulans expression was unaffected by dextrose repression, heat shock, or oxygen levels.; Similarity: belongs to the 5-aminolevulinate synthases.; Title: strong similarity to 5-aminolevulinic acid synthase hemA - Aspergillus nidulans; See PMID 8319309; uncharacterized protein 352772 4989471 An17g01480 Aspergillus niger uncharacterized protein XP_001398377.1 350750 R 5061 CDS An17g01490 4989472 complement(join(353964..354172,354231..358050,358108..358653,358730..359248)) V 1 NT_166532.1 Remark: asynonym for INO80 from S. cerevisiae is YGL150c.; Similarity: to the DNA/RNA helicases, SNF2 family.; Title: strong similarity to DNA helicase Ino80 -Saccharomyces cerevisiae; See PMID 10361278; See PMID 10952318; See PMID 8585324; uncharacterized protein 359248 4989472 An17g01490 Aspergillus niger uncharacterized protein XP_001398378.1 353964 R 5061 CDS An17g01495 84593588 complement(join(359494..359497,359665..359989,360101..360332)) V 1 NT_166532.1 hypothetical protein 360332 84593588 An17g01495 Aspergillus niger hypothetical protein XP_059602826.1 359494 R 5061 CDS An17g01510 84593589 complement(join(360380..360455,360551..360583,360669..360790,360829..360927)) V 1 NT_166532.1 hypothetical protein 360927 84593589 An17g01510 Aspergillus niger hypothetical protein XP_059602827.1 360380 R 5061 CDS An17g01520 84593590 complement(join(361694..361804,361874..361953,362002..362127,362203..362258,362313..362440,362512..362582,362668..362900,363019..363156,363236..363384)) V 1 NT_166532.1 hypothetical protein 363384 84593590 An17g01520 Aspergillus niger hypothetical protein XP_059602828.1 361694 R 5061 CDS An17g01530 4989476 join(363417..364067,364125..364479,364531..364577) V 1 NT_166532.1 Catalytic activity: alcohol + NAD+ = aldehyde or ketone + NADH.; Gene-ID: adhA; Pathway: glycolysis / gluconeogenesis; fatty acid metabolism; bile acid biosynthesis; tyrosine metabolism; glycerolipid metabolism.; Remark: identical to Aspergillus niger adhA gene patent WO8704464-A.; Similarity: belongs to the Zn-dependent alcohol dehydrogenases.; alcohol-dehydrogenase adhA from patent WO8704464-A-Aspergillus niger 364577 adhA 4989476 adhA Aspergillus niger alcohol-dehydrogenase adhA from patent WO8704464-A-Aspergillus niger XP_001398382.1 363417 D 5061 CDS An17g01540 4989477 complement(join(365189..365343,365426..365810,365890..365976,366033..366565,366622..366759,366945..367145,367225..367303)) V 1 NT_166532.1 Remark: transport of 4-aminobutyric acid (GABA) in S. cerevisiae is mediated by three transport systems: the general amino acid permease (GAP1 gene), the proline permease (PUT4 gene), and a specific GABA permease (UGA4 gene) which is induced in the presence of GABA. Induction of UGA4 in the presence of GABA is exerted at the level of UGA4 mRNA accumulation, most probably at the level of transcription itself.; Title: strong similarity to GABA permease Uga4 -Saccharomyces cerevisiae; See PMID 8455553; uncharacterized protein 367303 4989477 An17g01540 Aspergillus niger uncharacterized protein XP_059602829.1 365189 R 5061 CDS An17g01550 4989478 complement(join(368338..369569,369621..370280,370359..370511,370589..370624,370810..370852)) V 1 NT_166532.1 Remark: efficient transport out of the prevacuolar compartment requires Nhx1p, and nhx1 delta cells exhibit phenotypes characteristic of the 'class E' group of vps mutants. In addition Nhx1p is required for protein trafficking even in the absence of the vacuolar ATPase.; Title: strong similarity to Na+-H+ antiporter Nha2 -Saccharomyces cerevisiae; See PMID 9507001; See PMID 11102523; uncharacterized protein 370852 4989478 An17g01550 Aspergillus niger uncharacterized protein XP_059602830.1 368338 R 5061 CDS An17g01560 4989479 complement(join(371288..371508,371680..371754,371818..372639,372698..373019,373085..373124,373221..373408)) V 1 NT_166532.1 Remark: OsSUT1 was expressed in source organs such as leaf blade, leaf sheath and germinating seed whereas little or no expression was observed in some sink organs such as the panicles before heading and the roots.; Remark: strong similarity to 5' EST an_2098 from Aspergillus niger.; Title: strong similarity to sucrose transport protein SUT1 - Oryza sativa; See PMID 9522469; uncharacterized protein 373408 4989479 An17g01560 Aspergillus niger uncharacterized protein XP_059602831.1 371288 R 5061 CDS An17g01570 84593591 complement(join(373565..373888,373974..374112,374204..374358)) V 1 NT_166532.1 Title: strong similarity to EST an_3450 -Aspergillus niger; uncharacterized protein 374358 84593591 An17g01570 Aspergillus niger uncharacterized protein XP_059602832.1 373565 R 5061 CDS An17g01580 4989481 complement(join(375006..375258,375316..375399,375515..377062,377127..377226,377343..377466)) V 1 NT_166532.1 Remark: S. cerevisiae Ste12p plays a key role in coupling signal transduction through MAP kinase modules to cell-specific or morphogenesis-specific gene expression required for mating and pseudohyphal (PH)/filamentous growth (FG). Ste12p homologues in the pathogenic yeasts Candida albicans and Filobasidiela neoformans apparently play similar roles during dimorphic transitions.; Title: strong similarity to homeodomain DNA-binding transcription factor ste12 - Aspergillus nidulans; See PMID 10792717; uncharacterized protein 377466 4989481 An17g01580 Aspergillus niger uncharacterized protein XP_001398387.1 375006 R 5061 CDS An17g01590 84593592 join(377562..377723,377835..377889,377955..378319) V 1 NT_166532.1 Title: weak similarity to hypothetical protein PFC0680w - Plasmodium falciparum; uncharacterized protein 378319 84593592 An17g01590 Aspergillus niger uncharacterized protein XP_059602833.1 377562 D 5061 CDS An17g01600 84593593 join(379469..379580,379689..379772,379817..380025) V 1 NT_166532.1 hypothetical protein 380025 84593593 An17g01600 Aspergillus niger hypothetical protein XP_059602834.1 379469 D 5061 CDS An17g01610 84593594 join(380148..380317,380476..380498,381029..381154,381215..381318,381476..381602,381644..381735,382089..382197,382230..382279,382331..382455,382520..382868) V 1 NT_166532.1 hypothetical protein 382868 84593594 An17g01610 Aspergillus niger hypothetical protein XP_059602835.1 380148 D 5061 CDS An17g01620 84593595 complement(join(382909..383072,383183..383466,383552..383749,383849..383880,383974..384048,384173..384232,384399..384509,384558..384619,384923..385022,385392..385476,385553..385623)) V 1 NT_166532.1 hypothetical protein 385623 84593595 An17g01620 Aspergillus niger hypothetical protein XP_059602836.1 382909 R 5061 CDS An17g01630 4989486 complement(join(386027..386557,386617..386973)) V 1 NT_166532.1 Title: strong similarity to hypothetical protein SPAC3F10.08c - Schizosaccharomyces pombe; uncharacterized protein 386973 4989486 An17g01630 Aspergillus niger uncharacterized protein XP_001398392.1 386027 R 5061 CDS An17g01640 4989487 join(387277..387576,387718..387904,388029..388312) V 1 NT_166532.1 Catalytic activity: N-(5'-Phospho-D-ribosylformimino)-5-amino-1-(5''-phospho-D -ribosyl)-4-imidazolecarboxamide = N-(5'-Phospho-D-1'-ribulosylformimino)-5-amino-1-(5''-phos pho-D-ribosyl)-4-imidazolecarboxamide.; Pathway: histidine metabolism.; Remark: Soybean histidine biosynthetic enzyme HisA from clone sls1c. pk013. i8 patent WO200024867-A2.; Remark: the patent sequence is used in the construction of a chimeric gene to alter levels of the HisA enzyme in transformed plant cells. It may also be used for discovering compounds that have the ability to inhibit activity of the isomerase, and therefore act as herbicides and fungicides.; Similarity: belongs to the N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphori bosyl)-4-imidazolecarboxamide isomerases.; Title: strong similarity to biosynthetic enzyme HisA from patent WO200024867-A2 - Glycine max; uncharacterized protein 388312 4989487 An17g01640 Aspergillus niger uncharacterized protein XP_001398393.1 387277 D 5061 CDS An17g01650 4989488 join(388570..388949,389018..389075,389150..389476) V 1 NT_166532.1 Title: weak similarity to En/Spm-like transposon protein PDF1 - Arabidopsis thaliana; uncharacterized protein 389476 4989488 An17g01650 Aspergillus niger uncharacterized protein XP_059602837.1 388570 D 5061 CDS An17g01660 4989489 complement(join(390314..391740,391794..392094)) V 1 NT_166532.1 Catalytic activity: acetyl-CoA + histone = CoA + acetylhistone.; Remark: the yeast enzyme acetylates core histones in vitro; supposed to play a role as tightly RNAPII-associated histone acetyltransferase in transcription of DNA packaged in chromatin.; Title: strong similarity to histone acetyltransferase Elp3 - Saccharomyces cerevisiae; uncharacterized protein 392094 4989489 An17g01660 Aspergillus niger uncharacterized protein XP_001398395.1 390314 R 5061 CDS An17g01670 4989490 join(392540..392709,392793..392821,392899..393025,393086..393148,393209..393234,393309..393391,393471..393971) V 1 NT_166532.1 Catalytic activity: (EC:6. 2. 1. 4) GTP + succinate + CoA = GDP + orthophosphate + succinyl-CoA; ITP + succinate + CoA = IDP + orthophosphate + succinyl-CoA; GTP + itaconate + CoA = GDP + orthophosphate + itaconyl-CoA; ITP + itaconate + CoA = IDP + orthophosphate + itaconyl-CoA.; Catalytic activity: (EC:6. 2. 1. 5) ATP + succinate + CoA = ADP + orthophosphate + succinyl-CoA.; Function: the rat enzyme catalyzes the stepwise synthesis of succinyl-CoA from succinate, CoA, and GTP in the presence of magnesium ion, involving phosphoryl enzyme and enzyme-bound succinyl phosphate as intermediates. The active enzyme is an alpha-beta dimer.; Pathway: Citrate cycle (TCA cycle); Propanoate metabolism; C5-Branched dibasic acid metabolism; Reductive carboxylate cycle (CO2 fixation).; Remark: succinyl-CoA synthetase [succinate-CoA ligase (GDP-forming); EC 6. 2. 1. 4] of rat liver, an alpha beta dimer, is a component of the enzymology of the tricarboxylic acid cycle and functions within the mitochondrial matrix.; Similarity: to succinate-CoA ligase (ADP-forming) alpha chain.; Title: strong similarity to succinyl coenzyme A synthase alpha subunit SYRTSA - Rattus norvegicus; See PMID 3422742; uncharacterized protein 393971 4989490 An17g01670 Aspergillus niger uncharacterized protein XP_001398396.1 392540 D 5061 CDS An17g01680 84593596 complement(join(394299..394359,394439..394484,394577..394772)) V 1 NT_166532.1 hypothetical protein 394772 84593596 An17g01680 Aspergillus niger hypothetical protein XP_059602838.1 394299 R 5061 CDS An17g01690 84593597 join(395973..396092,396188..396238,396702..396751,396794..396849,397312..397391) V 1 NT_166532.1 Title: questionable ORF; uncharacterized protein 397391 84593597 An17g01690 Aspergillus niger uncharacterized protein XP_059602839.1 395973 D 5061 CDS An17g01700 84593598 complement(join(398420..398600,398811..398863,398951..399072,399165..399287,399331..399415,399496..399772,399863..400032)) V 1 NT_166532.1 hypothetical protein 400032 84593598 An17g01700 Aspergillus niger hypothetical protein XP_059602840.1 398420 R 5061 CDS An17g01710 4989494 join(400210..400470,400528..400768,400818..400886,400937..401383,401443..401999) V 1 NT_166532.1 Remark: Yil120wp was implicated in yeast resistance to ketoconazole and quinidine, but not to the stereoisomer quinine; the gene was thus named QDR1. Qdr1p was proved to alleviate the deleterious effects of quinidine, revealed by the loss of cell viability following sudden exposure of the unadapted yeast population to the drug, and to allow the earlier eventual resumption of exponential growth under quinidine stress.; Remark: alternative name is YIL120w.; Remark: the predicted ORF shows similarity to EST an_2526 from A. niger.; Similarity: belongs to the permeases of the major facilitator superfamily.; Title: similarity to multidrug resistance protein Qdr1 - Saccharomyces cerevisiae; See PMID 11302822; uncharacterized protein 401999 4989494 An17g01710 Aspergillus niger uncharacterized protein XP_001398400.1 400210 D 5061 CDS An17g01720 4989495 join(402970..402985,403119..403845,403903..404220,404273..405869) V 1 NT_166532.1 Remark: the A. chrysogenum RFX protein CPCR1 recognizes an imperfect palindrome, which resembles binding sites of human RFX transcription factors. One- and two-hybrid experiments with shorter versions of CPCR1 showed that the protein forms a DNA binding homodimer. Nondenaturing electrophoresis revealed that the CPCR1 protein exists in vitro solely in a multimeric, probably dimeric, state.; Title: strong similarity to RFX transcription factor CPCR1 - Penicillium chrysogenum; See PMID 10734077; uncharacterized protein 405869 4989495 An17g01720 Aspergillus niger uncharacterized protein XP_001398401.1 402970 D 5061 CDS An17g01730 4989496 complement(join(405991..406129,406405..406510,406634..406788,407395..407514,407579..409239,409355..409357)) V 1 NT_166532.1 Title: similarity to hypothetical protein AAK58053.1 - Ophiostoma novo-ulmi; uncharacterized protein 409357 4989496 An17g01730 Aspergillus niger uncharacterized protein XP_059602841.1 405991 R 5061 CDS An17g01740 4989497 join(409977..410016,410091..410148,410214..410385,410438..411331) V 1 NT_166532.1 Function: along with Uba2p forms Aos1p heterodimeric activating enzyme for the ubiquitin-like modifyer Smt3p/SUMO in a mechanism reminiscent of the ubiquitin conjugation pathway.; Remark: alternative name for the S. cerevisiae homolog gene AOS1 is YPR180w; Title: strong similarity to Smt3p activating enzyme Aos1 - Saccharomyces cerevisiae; See PMID 9312010; uncharacterized protein 411331 4989497 An17g01740 Aspergillus niger uncharacterized protein XP_001398403.1 409977 D 5061 CDS An17g01750 4989498 complement(join(412053..412388,412446..413288,413395..413472,413546..413671)) V 1 NT_166532.1 Remark: S. cerevisiae YTP1 gene encodies a type-III integral membrane protein with domains of sequence similarity to mitochondrial electron-transport enzymes.; Title: strong similarity to hypothetical membrane protein Ytp1 - Saccharomyces cerevisiae; See PMID 8635735; See PMID 9271199; uncharacterized protein 413671 4989498 An17g01750 Aspergillus niger uncharacterized protein XP_059602842.1 412053 R 5061 CDS An17g01760 4989499 join(414278..414355,414407..414492,414579..414738) V 1 NT_166532.1 Title: similarity to hypothetical protein SPBC409.03 - Schizosaccharomyces pombe; uncharacterized protein 414738 4989499 An17g01760 Aspergillus niger uncharacterized protein XP_001398405.1 414278 D 5061 CDS An17g01770 4989500 complement(join(415259..415616,415673..418983,419047..>419181)) V 1 NT_166532.1 Remark: N-terminal truncated ORF due to end of contig.; Remark: also strong similarity to multiple drug resistance protein AfuMDR1 from Aspergillus fumigatus patent US5914246-A.; Remark: expression of AFUMDR1 in S. cerevisiae conferred increased resistance to the antifungal agent cilofungin (LY121019), an echinocandin B analog.; Title: strong similarity to multidrug resistance protein mdr1 - Aspergillus fumigatus [truncated ORF]; plasma membrane; See PMID 9373135; uncharacterized protein 419181 4989500 An17g01770 Aspergillus niger uncharacterized protein XP_001398406.1 415259 R 5061 CDS An17g01795 4989501 421938..423263 V 1 NT_166532.1 Title: weak similarity to protein of retrotransposon Ty1 Tyb - Saccharomyces cerevisiae; uncharacterized protein 423263 4989501 An17g01795 Aspergillus niger uncharacterized protein XP_001398407.1 421938 D 5061 CDS An17g01805 4989502 join(426772..428445,428509..428613,428670..429422) V 1 NT_166532.1 Title: weak similarity to protease type 2 Iga1 -Haemophilus influenzae; uncharacterized protein 429422 4989502 An17g01805 Aspergillus niger uncharacterized protein XP_059605864.1 426772 D 5061 CDS An17g01815 4989503 join(430283..430317,430418..430489,430549..430634,430705..430894,430956..431316) V 1 NT_166532.1 Alternative name: YPR016c; Function: the S. cerevisiae protein eIF6, is necessary for maximal polysome formation and plays an important role in determining free 60 S ribosomal subunit content.; Title: strong similarity to translation initiation factor Eif6 - Saccharomyces cerevisiae; cytoplasm; See PMID 9891075; See PMID 10206977; uncharacterized protein 431316 4989503 An17g01815 Aspergillus niger uncharacterized protein XP_059605865.1 430283 D 5061 CDS An17g01823 84593599 433000..433503 V 1 NT_166532.1 hypothetical protein 433503 84593599 An17g01823 Aspergillus niger hypothetical protein XP_059605866.1 433000 D 5061 CDS An17g01825 4989505 complement(join(433635..435316,435612..436134)) V 1 NT_166532.1 Title: strong similarity to huntingtin interacting protein 1 HIF-1 - Homo sapiens; uncharacterized protein 436134 4989505 An17g01825 Aspergillus niger uncharacterized protein XP_059605867.1 433635 R 5061 CDS An17g01835 84593600 complement(join(439031..439065,439123..439138,439230..439251,439516..439546,439785..439866,439915..440175,440351..440539)) V 1 NT_166532.1 hypothetical protein 440539 84593600 An17g01835 Aspergillus niger hypothetical protein XP_059605868.1 439031 R 5061 CDS An17g01845 84593601 complement(join(441027..441194,441269..441319)) V 1 NT_166532.1 hypothetical protein 441319 84593601 An17g01845 Aspergillus niger hypothetical protein XP_059605869.1 441027 R 5061 CDS An17g01855 4989508 join(443215..443317,443593..444467) V 1 NT_166532.1 hypothetical protein 444467 4989508 An17g01855 Aspergillus niger hypothetical protein XP_059605870.1 443215 D 5061 CDS An17g01865 4989509 complement(join(446323..446964,447034..447171,447230..448021,448090..448239,448369..448438,448571..448656)) V 1 NT_166532.1 Catalytic activity: ATP + protein <=> ADP + O-phosphoprotein.; Function: E. nidulans spores lacking CmkC germinate with delayed kinetics and a lag in the activation of the cell cycle relevant kinase NIMX(cdc2).; Title: strong similarity to calcium/calmodulin dependent protein kinase cmkC - Aspergillus nidulans; See PMID 10988293; uncharacterized protein 448656 4989509 An17g01865 Aspergillus niger uncharacterized protein XP_059605871.1 446323 R 5061 CDS An17g01875 4989510 join(449556..449592,449667..449877,449953..450098,450165..450277) V 1 NT_166532.1 Localization: the mouse Synbindin is structurally related to yeast proteins known to be involved in vesicle transport. Immunoelectron microscopy localized synbindin on postsynaptic membranes and intracellular vesicles within dendrites, suggesting a role in postsynaptic membrane trafficking.; Title: similarity to protein Synbindin - Mus musculus; intracellular transport vesicles; See PMID 11018053; uncharacterized protein 450277 4989510 An17g01875 Aspergillus niger uncharacterized protein XP_001398416.3 449556 D 5061 CDS An17g01885 4989511 complement(join(450578..450704,450861..451017,451106..451307)) V 1 NT_166532.1 Title: weak similarity to IgA-specific metalloendopeptidase type 1 precursor IGA - Haemophilus influenzae; uncharacterized protein 451307 4989511 An17g01885 Aspergillus niger uncharacterized protein XP_001398417.3 450578 R 5061 CDS An17g01895 84593602 join(452171..452448,452533..452917) V 1 NT_166532.1 hypothetical protein 452917 84593602 An17g01895 Aspergillus niger hypothetical protein XP_059605872.1 452171 D 5061 CDS An17g01905 84593603 complement(join(454782..455173,455407..455506,455558..455689)) V 1 NT_166532.1 hypothetical protein 455689 84593603 An17g01905 Aspergillus niger hypothetical protein XP_059605873.1 454782 R 5061 CDS An17g01915 84593604 join(456990..457210,457449..457539) V 1 NT_166532.1 hypothetical protein 457539 84593604 An17g01915 Aspergillus niger hypothetical protein XP_059605874.1 456990 D 5061 CDS An17g01925 4989515 join(460441..461877,461937..462068) V 1 NT_166532.1 Remark: alternate names for the S. cerevisiae Hal4 kinase: Sat4 or YOR008W.; Remark: the S. cerevisiae Hal4 and Hal5 kinases are partially redundant. hal4 hal5 double mutants exhibit following phenotypes: (i) they are deficient in potassium uptake; (ii) their growth is sensitive to a variety of toxic cations, including lithium, sodium, calcium,tetramethylammonium, hygromycin B, and low pH; and (iii) they exhibit increased uptake of methylammonium, an indicator of membrane potential.; Title: strong similarity to serine/threonine-specific protein kinase Hal4 -Saccharomyces cerevisiae; See PMID 10207057; uncharacterized protein 462068 4989515 An17g01925 Aspergillus niger uncharacterized protein XP_001398421.1 460441 D 5061 CDS An17g01935 84593605 join(463074..463371,463771..464016,464203..464351) V 1 NT_166532.1 Title: weak similarity to HIC-1 polypeptide from patent WO9614877-A1 - Homo sapiens; uncharacterized protein 464351 84593605 An17g01935 Aspergillus niger uncharacterized protein XP_059605875.1 463074 D 5061 CDS An17g01945 4989517 join(465835..465847,465952..466002,466120..466165,466235..466308,466387..466534,466605..467058) V 1 NT_166532.1 Function: the S. cerevisisae Rvs161 protein is a component of a cytoskeletal structure that is required for the formation of endocytic vesicles at the plasma membrane level. S. cerevisiae rvs161 mutations result in sensitivity to carbon, nitrogen and sulfur starvation.; Remark: alternate names for the S. cerevisiae Rvs161 protein: End6, Fus7, Spe161 or YCR009C.; Similarity: the predicted A. niger protein shows strong similarity to protein Rvs161 from S. cerevisiae and amphiphysins of higher eukaryotes.; Title: strong similarity to protein Rvs161 -Saccharomyces cerevisiae; cytoskeleton; See PMID 10992286; See PMID 1776363; See PMID 7891662; See PMID 9614182; uncharacterized protein 467058 4989517 An17g01945 Aspergillus niger uncharacterized protein XP_001398423.1 465835 D 5061 CDS An17g01955 4989518 complement(join(467264..467307,467384..468401)) V 1 NT_166532.1 Similarity: the ORF encoded protein shows also similarity to some putative aminoacyl-tRNA hydrolases.; Title: similarity to rhoGAP homolog DdRacGAP -Dictyostelium discoideum; See PMID 9188459; uncharacterized protein 468401 4989518 An17g01955 Aspergillus niger uncharacterized protein XP_059605876.1 467264 R 5061 CDS An17g01965 4989519 join(469636..469787,469860..470748) V 1 NT_166532.1 Title: similarity to heptaprenyl diphosphate synthetase ORFII from patent EP699761-A2 - Bacillus stearothermophilus; uncharacterized protein 470748 4989519 An17g01965 Aspergillus niger uncharacterized protein XP_001398425.3 469636 D 5061 CDS An17g01975 4989520 complement(471154..472485) V 1 NT_166532.1 Function: the S. cerevisiae Imp4 protein is a component of the U3 small nucleolar ribonucleoprotein (U3 snoRNP). It interacts physically with the U3 snoRNP specific protein, Mpp10. It is required for the early cleavages at sites A0, A1 and A2 of the pre ribosomal RNA to yield pre 18s ribosomal RNA processing.; Remark: alternate name for S. cerevisiae Imp4: YNL075W.; Title: strong similarity to component of the U3 snoRNP Imp4 - Saccharomyces cerevisiae; nucleus; See PMID 10409734; uncharacterized protein 472485 4989520 An17g01975 Aspergillus niger uncharacterized protein XP_001398426.1 471154 R 5061 CDS An17g01977 4989521 472854..474734 V 1 NT_166532.1 Function: A mutation in Grs1 from S. cerevisiae affects 3'-end formation.; Remark: Grs1 from S. cerevisiae encodes the cytoplasmic glycyl-tRNA synthetase.; Title: strong similarity to glycine-tRNA ligase Grs1 - Saccharomyces cerevisiae; cytoplasm; See PMID 10224248; See PMID 10874035; uncharacterized protein 474734 4989521 An17g01977 Aspergillus niger uncharacterized protein XP_001398427.3 472854 D 5061 CDS An17g02010 4989522 complement(join(477604..478016,478067..478166,478229..480242,480382..480398)) V 1 NT_166532.1 Function: the S. cerevisiae kinase Cla4 is involved in budding and cytokinesis and interacts with Cdc42.; Remark: alternate names for S. cerevisiae Cla4: Erc10 or YNL298W.; Title: strong similarity to serine/threonine protein kinase Cla4 - Saccharomyces cerevisiae; See PMID 9271384; See PMID 11134337; uncharacterized protein 480398 4989522 An17g02010 Aspergillus niger uncharacterized protein XP_001398428.3 477604 R 5061 CDS An17g02020 4989523 complement(join(482623..483694,483759..483873,483955..484048)) V 1 NT_166532.1 Catalytic activity: ATP + NADH <=> ADP + NADPH.; Function: the NADH kinase may be involved in maintaining the level of triphosphopyridine nucleotide in the mitochondria.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to NADH kinase from patent JP09131185-A - Pichia membranaefaciens; uncharacterized protein 484048 4989523 An17g02020 Aspergillus niger uncharacterized protein XP_001398429.3 482623 R 5061 CDS An17g02030 4989524 join(484968..485833,485896..486283) V 1 NT_166532.1 Title: strong similarity to 2-acyltransferase from patent WO9413814-A - Zea mays; uncharacterized protein 486283 4989524 An17g02030 Aspergillus niger uncharacterized protein XP_001398430.1 484968 D 5061 CDS An17g02040 4989525 join(487102..487956,488029..488769,488815..490818) V 1 NT_166532.1 Remark: alternate names for S. cerevisiae Ctr9: Cdp1 or YOL145C.; Similarity: the ORF encoded protein shows also strong similarity to the S. pombe homolog of the S. cerevisiae Ctr9 protein Tpr1 from which the gene has been identified as suppressor of the S. cerevisiae Delta trk1,2 potassium uptake deficient phenotype (Pubmed 10471809). The S. cerevisiae Ctr9 protein seems to be better characterized.; Title: strong similarity to protein required for normal CLN1 and CLN2 G1 cyclin expression Ctr9 -Saccharomyces cerevisiae; See PMID 8978028; See PMID 10219085; uncharacterized protein 490818 4989525 An17g02040 Aspergillus niger uncharacterized protein XP_059602843.1 487102 D 5061 CDS An17g02050 84593606 join(492253..492362,492498..492645) V 1 NT_166532.1 hypothetical protein 492645 84593606 An17g02050 Aspergillus niger hypothetical protein XP_059602844.1 492253 D 5061 CDS An17g02060 4989527 join(<497361..497691,497772..499699) V 1 NT_166532.1 Remark: due to contig end.; Title: weak similarity to hypothetical gastric mucin clone PGM-2A - Sus scrofa [truncated ORF]; uncharacterized protein 499699 4989527 An17g02060 Aspergillus niger uncharacterized protein XP_001398433.1 497361 D 5061 CDS An17g02070 4989528 500640..502073 V 1 NT_166532.1 Title: strong similarity to hypothetical protein ES2 - Mus musculus; uncharacterized protein 502073 4989528 An17g02070 Aspergillus niger uncharacterized protein XP_001398434.1 500640 D 5061 CDS An17g02075 4989529 complement(join(502766..503439,503500..504658)) V 1 NT_166532.1 Function: The expression of the yam8(+) cDNA from S. pombe in the S. cerevisiae mid1 mutant cells partially remediated the mid phenotype and resulted in a slight increase in Ca(2+) uptake activity.; Function: the yam8(+) cDNA from S. pombe, placed under the S. cerevisiae TDH3 promoter, partially complemented the mating pheromone-induced death (mid) phenotype of the S. cerevisiae mid1 mutant.; Title: strong similarity to stretch-activated Ca2+-permeable channel protein homolog yam8p -Schizosaccharomyces pombe; See PMID 10694511; uncharacterized protein 504658 4989529 An17g02075 Aspergillus niger uncharacterized protein XP_001398435.1 502766 R 5061 CDS An17g02080 4989530 complement(join(505245..505824,505894..507305)) V 1 NT_166532.1 Title: strong similarity to hypothetical protein SPBC27B12.12c - Schizosaccharomyces pombe; uncharacterized protein 507305 4989530 An17g02080 Aspergillus niger uncharacterized protein XP_001398436.1 505245 R 5061 CDS An17g02090 4989531 join(510106..510529,510642..510940,511019..511360) V 1 NT_166532.1 Catalytic activity: ATP + L-homoserine <=> ADP + O-phospho-L-homoserine; Title: strong similarity to homoserine kinase Thr1 -Saccharomyces cerevisiae; uncharacterized protein 511360 4989531 An17g02090 Aspergillus niger uncharacterized protein XP_001398437.1 510106 D 5061 CDS An17g02095 4989532 join(512202..512282,512362..512565) V 1 NT_166532.1 Function: Overexpression of SPC1 from S. cerevisiae supresses the conditional sec11 mutation.; Function: Spc1p from S. cerevisiae co-purifies and genetically interacts with Sec11p, a subunit of the signal peptidase that catalyzes the cleavage of signal peptides and the degradation of some membrane proteins within the endoplasmic reticulum (ER).; Function: Spc1p from S. cerevisiae is not required for cell growth or the proteolytic processing of tested proteins in yeast.; Function: a deletion mutant of SPC1 from S. cerevisiae is synthetically lethal with a conditional mutation affecting Sec11p.; Similarity: Spc1p from S. cerevisiae is the homologue to mammalian signal peptidase subunit SPC12.; Title: similarity to signal peptidase subunit Spc1 -Saccharomyces cerevisiae; See PMID 8663399; See PMID 8910564; uncharacterized protein 512565 4989532 An17g02095 Aspergillus niger uncharacterized protein XP_059606807.1 512202 D 5061 CDS An17g02100 4989533 complement(join(512806..512904,512971..513041,513103..513181,513248..513358)) V 1 NT_166532.1 Complex: human ring-box protein 1 binds VHL protein,CUL1, CUL2 and Elongins B and C.; Complex: human ring-box protein 1 is a component of both the VHL and SCF/Cdc4 complexes.; Function: the yeast homolog of Rbx1 is a subunit and potent activator of the Cdc53-containing SCF/Cdc4 ubiquitin ligase required for ubiquitination of the cyclin-dependent kinase inhibitor Sic1 and for the G1 to S cell cycle transition.; Similarity: the predicted A. niger protein shows strong similarity to the human ring-box protein 1 (RBX1),which belongs to the ring finger proteins.; Title: strong similarity to ring-box protein 1 RBX1 - Homo sapiens; See PMID 10213691; uncharacterized protein 513358 4989533 An17g02100 Aspergillus niger uncharacterized protein XP_001398439.1 512806 R 5061 CDS An17g02110 4989534 514473..515879 V 1 NT_166532.1 Title: weak similarity to hypothetical protein KIAA0324 - Homo sapiens; uncharacterized protein 515879 4989534 An17g02110 Aspergillus niger uncharacterized protein XP_001398440.1 514473 D 5061 CDS An17g02120 4989535 join(519639..519649,519739..521305) V 1 NT_166532.1 Catalytic activity: UDP-glucose + {(1,3)-beta-D-glucosyl}(N) <=> UDP + {(1,3)-beta-D-glucosyl}(N+1); Title: strong similarity to 1,3-beta-glucan synthase gs-1 - Neurospora crassa; uncharacterized protein 521305 4989535 An17g02120 Aspergillus niger uncharacterized protein XP_001398441.1 519639 D 5061 CDS An17g02130 4989536 complement(522188..522916) V 1 NT_166532.1 Title: strong similarity to protein fragment SEQ ID NO:28055 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 522916 4989536 An17g02130 Aspergillus niger uncharacterized protein XP_001398442.1 522188 R 5061 CDS An17g02140 4989537 join(524114..524356,524437..524524,524593..524964,525030..525472) V 1 NT_166532.1 Title: strong similarity to vanadate resistance protein Van2 - Saccharomyces cerevisiae; uncharacterized protein 525472 4989537 An17g02140 Aspergillus niger uncharacterized protein XP_001398443.1 524114 D 5061 CDS An17g02150 4989538 join(526622..526919,527208..528256) V 1 NT_166532.1 Title: similarity to hypothetical protein YIL096c -Saccharomyces cerevisiae; uncharacterized protein 528256 4989538 An17g02150 Aspergillus niger uncharacterized protein XP_059606808.1 526622 D 5061 CDS An17g02160 4989539 complement(join(528466..528497,528568..528799,528857..529051,529120..529788)) V 1 NT_166532.1 Title: similarity to erythroblast macrophage protein EMP - Homo sapiens; See PMID 9763581; uncharacterized protein 529788 4989539 An17g02160 Aspergillus niger uncharacterized protein XP_059606809.1 528466 R 5061 CDS An17g02170 4989540 complement(join(530253..530582,530640..530866,530921..531552,531612..531768,531830..531941)) V 1 NT_166532.1 Title: strong similarity to centromere/microtubule-binding protein Cbf5 - Saccharomyces cerevisiae; uncharacterized protein 531941 4989540 An17g02170 Aspergillus niger uncharacterized protein XP_001398446.1 530253 R 5061 CDS An17g02180 4989541 complement(join(532499..532911,532970..533012,533431..533528,533578..533756,533811..533845)) V 1 NT_166532.1 Title: similarity to hypothetical eIF-3 p110 subunit - Caenorhabditis elegans; uncharacterized protein 533845 4989541 An17g02180 Aspergillus niger uncharacterized protein XP_001398447.1 532499 R 5061 CDS An17g02190 4989542 complement(join(534542..534924,534989..535718)) V 1 NT_166532.1 Title: similarity to hypothetical protein SPBC1105.15c - Schizosaccharomyces pombe; uncharacterized protein 535718 4989542 An17g02190 Aspergillus niger uncharacterized protein XP_001398448.1 534542 R 5061 CDS An17g02200 4989543 join(535937..535990,536048..536938) V 1 NT_166532.1 Title: similarity to hypothetical chorismate mutase/prephenate dehydratase pheA - Aquifex aeolicus; uncharacterized protein 536938 4989543 An17g02200 Aspergillus niger uncharacterized protein XP_059606810.1 535937 D 5061 CDS An17g02210 4989544 complement(join(537373..537416,537468..537614,537690..538818,538881..538930,538994..539114)) V 1 NT_166532.1 Title: strong similarity to peptide chain release factor eRF-1 - Homo sapiens; uncharacterized protein 539114 4989544 An17g02210 Aspergillus niger uncharacterized protein XP_059606811.1 537373 R 5061 CDS An17g02220 4989545 join(540765..540940,541009..542126,542183..542280,542392..542562) V 1 NT_166532.1 Title: strong similarity to hypothetical protein YJR001w - Saccharomyces cerevisiae; uncharacterized protein 542562 4989545 An17g02220 Aspergillus niger uncharacterized protein XP_059606812.1 540765 D 5061 CDS An17g02230 4989546 complement(543058..543921) V 1 NT_166532.1 Title: strong similarity to hypothetical protein YBR141c - Saccharomyces cerevisiae; uncharacterized protein 543921 4989546 An17g02230 Aspergillus niger uncharacterized protein XP_001398452.1 543058 R 5061 CDS An17g02240 4989547 join(544279..544306,544583..544644,544714..545000,545066..545153) V 1 NT_166532.1 Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L23a - Rattus norvegicus; cytoplasm; 60S ribosomal protein uL23 545153 4989547 An17g02240 Aspergillus niger 60S ribosomal protein uL23 XP_001398453.1 544279 D 5061 CDS An17g02250 4989548 join(546374..546545,546617..546747,546883..547026) V 1 NT_166532.1 Title: strong similarity to protein G10 - Xenopus laevis; uncharacterized protein 547026 4989548 An17g02250 Aspergillus niger uncharacterized protein XP_001398454.1 546374 D 5061 CDS An17g02270 84593607 complement(<549283..549978) V 1 NT_166532.1 Similarity: HNF-3beta of X. laevis is a member of the HNF-3/fork head transcription factor family.; Title: similarity to transcription factor HNF-3beta - Xenopus laevis; nucleus; See PMID 8155584; uncharacterized protein 549978 84593607 An17g02270 Aspergillus niger uncharacterized protein XP_059606813.1 549283 R 5061 CDS An17g02280 4989550 complement(join(552562..552659,552719..553968,554106..554186,554256..554404)) V 1 NT_166532.1 Catalytic activity: ATP + L-Aspartate = ADP + 4-Phospho-L-aspartate.; Remark: the synonyme for HOM3 from S. cerevisiae is YER052c.; Title: strong similarity to aspartate kinase Hom3 -Saccharomyces cerevisiae; See PMID 2892836; uncharacterized protein 554404 4989550 An17g02280 Aspergillus niger uncharacterized protein XP_001398456.1 552562 R 5061 CDS An17g02283 84593608 555687..556187 V 1 NT_166532.1 hypothetical protein 556187 84593608 An17g02283 Aspergillus niger hypothetical protein XP_059606814.1 555687 D 5061 CDS An17g02285 4989552 join(556251..556682,556737..556768,556817..556971,557033..557237,557305..557338) V 1 NT_166532.1 Title: similarity to kidney injury associated molecule HW034 protein 2 from patent WO9853071-A1 - Rattus sp.; uncharacterized protein 557338 4989552 An17g02285 Aspergillus niger uncharacterized protein XP_001398458.3 556251 D 5061 CDS An17g02287 4989553 complement(559200..559472) V 1 NT_166532.1 Title: similarity to sequence of the HAP-1 protein from patent WO9910482-A1 - Caenorhabditis elegans; uncharacterized protein 559472 4989553 An17g02287 Aspergillus niger uncharacterized protein XP_059606815.1 559200 R 5061 CDS An17g02290 4989554 complement(join(559796..559905,559958..560172,560229..560302,560361..564222,564278..564467,564518..564610,564684..564858)) V 1 NT_166532.1 Complex: MYO2 of S. cerevisiae belongs to the actin-associated motorproteins; Function: MYO2 of S. cerevisiae is involved in vacuole inheritance; polarized growth and secretion.; Function: MYO2 of S. cerevisiae plays a role in vesicle transport along actin cables to the bud site.; Title: strong similarity to myosin Myo2 -Saccharomyces cerevisiae; cytoskeleton; See PMID 2016335; uncharacterized protein 564858 4989554 An17g02290 Aspergillus niger uncharacterized protein XP_059606816.1 559796 R 5061 CDS An17g02300 4989555 complement(join(566091..566141,566201..566544,566598..567311,567363..567442,567530..567576)) V 1 NT_166532.1 Function: NAP-1 is involved in assembling histones into an octamer.; Phenotype: nap-1 null mutant cells do not experience benomyl-induced mitotic delay possibly because absence of Nap1p increases microtubule stability.; Phenotype: nap-1 null mutants have delay at the short spindle stage of mitosis.; Title: strong similarity to nucleosome assembly protein I Nap-i - Saccharomyces cerevisiae; nucleus; See PMID 2016313; uncharacterized protein 567576 4989555 An17g02300 Aspergillus niger uncharacterized protein XP_001398461.1 566091 R 5061 CDS An17g02310 4989556 join(568743..568831,568885..568924,568981..569496,569550..569888,569939..570073,570122..570188,570252..570383,570435..570784,570837..570982,571034..571183,571270..571502,571565..571708,571762..572094,572143..572231,572289..572423,572510..572742,572802..572925,572980..573025,573092..573242,573305..573453,573503..573789) V 1 NT_166532.1 Function: overexpression of SPF1 of S. cerevisiae gives resistance against Pichia farinosa killer toxin.; Remark: the ORFencoded protein also shows similarity to other transporting ATPases.; Title: similarity to Ca2+-transporting ATPase Spf1 -Saccharomyces cerevisiae; See PMID 10361284; uncharacterized protein 573789 4989556 An17g02310 Aspergillus niger uncharacterized protein XP_059606817.1 568743 D 5061 CDS An17g02320 4989557 join(574946..575055,575106..575187,575244..575340,575390..575544,575594..575621,575672..575885,575936..576130,576201..576981) V 1 NT_166532.1 Function: SGV1 is involved in pheromone adaptation pathway and in cell cycle.; Function: SGV1 probably acts by phosphorylating the G1 cyclins or the Ste4p.; Phenotype: sgv1 knockout mutation is suppressed by activated Cln3p.; Remark: the ORF encoded protein show similarity to many hypothetical protein kinases and also contains corresponding Prosite and PFAM Domains.; Title: strong similarity to protein kinase Sgv1 -Saccharomyces cerevisiae; See PMID 8293972; See PMID 1828190; uncharacterized protein 576981 4989557 An17g02320 Aspergillus niger uncharacterized protein XP_059606818.1 574946 D 5061 CDS An17g02330 4989558 complement(join(577655..577783,577836..577894,577949..577991,578048..578637,578688..578995,579059..579372)) V 1 NT_166532.1 Catalytic activity: SerA of E. coli catalyzes the reaction of 3-phosphoglycerate + NAD(+) = 3-phosphohydroxypyruvate + NADH.; Pathway: SerA of E. coli catalyzes the first committed step in the 'phosphorylated' pathway of L-serine biosynthesis.; Similarity: SerA of E. coli belongs to the D-isomer specific 2-hydroxyacid dehydrogenases family.; Title: strong similarity to phosphoglycerate dehydrogenase serA - Escherichia coli; See PMID 7719856; See PMID 3017965; uncharacterized protein 579372 4989558 An17g02330 Aspergillus niger uncharacterized protein XP_001398464.3 577655 R 5061 CDS An17g02340 4989559 complement(join(580021..580197,580253..580621,580672..580762,580818..581239,581299..581460,581564..581634,581699..581831)) V 1 NT_166532.1 Catalytic activity: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).; Similarity: SES1 of S. cerevisiae is a member of class II aminoacyl-tRNA synthetases.; Title: strong similarity to cytosolic serine--tRNA ligase Ses1 - Saccharomyces cerevisiae; cytoplasm; See PMID 3031581; uncharacterized protein 581831 4989559 An17g02340 Aspergillus niger uncharacterized protein XP_001398465.1 580021 R 5061 CDS An17g02350 4989560 complement(join(582392..582631,582685..582813,582874..583013,583083..583137)) V 1 NT_166532.1 Function: rheb binds [alpha-32P]GTP.; Similarity: rheb is a member of the ras-related GTP-binding proteins.; Title: strong similarity to ras-related GTP-binding protein rheb - Homo sapiens; See PMID 8543055; uncharacterized protein 583137 4989560 An17g02350 Aspergillus niger uncharacterized protein XP_001398466.1 582392 R 5061 CDS An17g02360 4989561 complement(join(583733..584014,584067..586124)) V 1 NT_166532.1 Title: strong similarity to hypothetical protein CAD70983.1 - Neurospora crassa; uncharacterized protein 586124 4989561 An17g02360 Aspergillus niger uncharacterized protein XP_001398467.1 583733 R 5061 CDS An17g02370 4989562 join(587806..587954,588025..588387,588429..>588640) V 1 NT_166532.1 Catalytic activity: FUR1 of S. cerevisiae catalyzes the reaction of UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.; Pathway: FUR1 of S. cerevisiae is involved in the salvage pathway of pyrimidine metabolism.; Remark: a putative sequencing error results in an frameshift.; Title: strong similarity to uracil phosphoribosyltransferase Fur1 - Saccharomyces cerevisiae [putative frameshift]; cytoplasm; putative frameshift; See PMID 2189783; uncharacterized protein 588640 4989562 An17g02370 Aspergillus niger uncharacterized protein XP_059606819.1 587806 D 5061 CDS An17g02380 4989563 complement(join(588925..589118,589179..589317,589468..589470)) V 1 NT_166532.1 Remark: ORF is identical to EST an_3047 of Aspergillus niger.; Title: strong similarity to hypothetical protein SPAC1B3.02c - Schizosaccharomyces pombe; uncharacterized protein 589470 4989563 An17g02380 Aspergillus niger uncharacterized protein XP_059606820.1 588925 R 5061 CDS An17g02390 10098096 join(590921..590934,591013..591097,591144..591169,591296..591797,591860..>592004) V 1 NT_166532.1 Remark: RP10B was previously confused with MFT1.; Remark: RP3B, PLC2, KRP-Y1 and RPS1B are alternative names for RP10B.; Remark: the ORF contains a putative sequencing error at position 2693.; Similarity: RP10B belongs to the S3AE family of ribosomal proteins.; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit Rp10b - Saccharomyces cerevisiae [putative frameshift]; cytoplasm; putative frameshift; See PMID 9396790; See PMID 9421530; 40S ribosomal protein eS1 592004 10098096 An17g02390 Aspergillus niger 40S ribosomal protein eS1 XP_059606821.1 590921 D 5061 CDS An17g02400 84593609 join(593004..593042,593126..593205,593487..593496,593554..593605,593741..593805) V 1 NT_166532.1 hypothetical protein 593805 84593609 An17g02400 Aspergillus niger hypothetical protein XP_059606822.1 593004 D 5061 CDS An03g00010 4980698 join(<2..122,187..1348,1410..2509,2572..2678,2735..3013,3066..3267,3324..4045,4255..4313,4400..4550) VI 1 NT_166520.1 Catalytic activity: 5-oxoprolinases catalyse ATP + 5-oxo-L-proline + 2 H(2)O <=> ADP + phosphate + L-glutamate.; Function: 5-oxoprolinases catalyze a reaction in which the endergonic cleavage of 5-oxo-L-proline to form L-glutamate is coupled to the exergonic hydrolysis of ATP to ADP and inorganic phosphate, which is e. g. necessary in glutathione metabolism.; Remark: OPLAH of R. norvegicus is also called 5-oxo-L-prolinase, pyroglutamase or 5-OPase.; Remark: the ORF is N-terminally truncated due to contig border.; Similarity: additionally to 5-oxoprolinases, the ORF shows some similarity to N-methylhydantoinases (EC 3. 5. 2. 14) from different species, which also have the property of hydrolyzing the imide bond of 5-membered rings.; Title: strong similarity to ATP-hydrolyzing 5-oxoprolinase - Rattus norvegicus [truncated ORF]; See PMID 2563377; See PMID 8943290; uncharacterized protein 4550 4980698 An03g00010 Aspergillus niger uncharacterized protein XP_001389908.3 2 D 5061 CDS An03g00020 4980707 join(6195..6293,6360..6387,6450..6513,6570..6818,6893..7130,7193..7264,7387..8706) VI 1 NT_166520.1 Similarity: the similarity of the ORF to the probable transcription factor btd of S. pombe is restricted to the N-terminal half of both putative proteins.; Title: similarity to hypothetical transcription factor btd - Schizosaccharomyces pombe; uncharacterized protein 8706 4980707 An03g00020 Aspergillus niger uncharacterized protein XP_059603558.1 6195 D 5061 CDS An03g00030 4980726 join(8874..8903,8963..9148,9216..9547,9613..10021) VI 1 NT_166520.1 Similarity: the ORF shows similarity to several putative oxidoreductases with various function.; Title: strong similarity to hypothetical 3-hydroxyisobutyrate dehydrogenase homolog b0509 -Escherichia coli; See PMID 10989433; uncharacterized protein 10021 4980726 An03g00030 Aspergillus niger uncharacterized protein XP_001389910.1 8874 D 5061 CDS An03g00040 4980727 complement(join(10510..11049,11119..11514)) VI 1 NT_166520.1 Catalytic activity: dihydrodipicolinate synthases catalyse L-aspartate 4-semialdehyde + pyruvate <=> dihydrodipicolinate + 2 H(2)O.; Function: dapA of C. glutamicum is involved in the lysine biosynthesis by catalyzing the first step in diaminopimelate and lysine biosynthesis.; Similarity: the ORF shows similarity to several bacterial dihydrodipicolinates.; Title: strong similarity to dihydrodipicolinate synthase dapA - Corynebacterium glutamicum; See PMID 8659901; See PMID 9559056; See PMID 10498736; uncharacterized protein 11514 4980727 An03g00040 Aspergillus niger uncharacterized protein XP_001389911.1 10510 R 5061 CDS An03g00050 84590584 join(11790..12083,12146..12620,12731..12973,13034..13122,13190..>13308) VI 1 NT_166520.1 Catalytic activity: aspartate transaminases catalyse e. g. L-aspartate + 2-oxoglutarate <=> oxaloacetate + L-glutamate.; Function: aspartate transaminases are involved in a variety of amino acid biosynthesis reactions.; Remark: a possible sequencing error occured at position 13058 leading to a stop codon, 1 base has been removed. A possible sequencing error occured at position 12469 leading to a stop codon, 1 base has been changed to N.; Title: strong similarity to cytosolic aspartate transaminase AspAT - Gallus gallus [putative frameshift]; putative frameshift; uncharacterized protein 13308 84590584 An03g00050 Aspergillus niger uncharacterized protein XP_059603559.1 11790 D 5061 CDS An03g00060 4980715 join(14315..14682,14743..15931) VI 1 NT_166520.1 Induction: in S. cerevisiae the relatively high basal level of DAL5 expression did not increase further upon addition of allantoin pathway intermediates.; Phenotype: the null mutant of S. cerevisiae DAL5 is viable, but unable to transport allontoate or ureidosuccinate.; Remark: DAL5 of S. cerevisiae is also called J223,YJR152w or UREp1.; Repression: in S. cerevisiae steady-state DAL5 mRNA levels dropped precipitously when a repressive nitrogen source was provided.; Similarity: DAL5 from S. cerevisiae is a member of the major facilitator family.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 10869563; uncharacterized protein 15931 4980715 An03g00060 Aspergillus niger uncharacterized protein XP_001389913.1 14315 D 5061 CDS An03g00070 84590585 complement(join(16369..16432,16496..16524,16597..16599)) VI 1 NT_166520.1 Remark: the ORF is only 31 amino acids long.; Title: questionable ORF; uncharacterized protein 16599 84590585 An03g00070 Aspergillus niger uncharacterized protein XP_059603560.1 16369 R 5061 CDS An03g00080 84590586 complement(join(17994..18177,18402..>18412)) VI 1 NT_166520.1 Remark: the ORF is N-terminally truncated due to contig border.; hypothetical protein [truncated ORF] 18412 84590586 An03g00080 Aspergillus niger hypothetical protein [truncated ORF] XP_059603561.1 17994 R 5061 CDS An03g00090 84590587 complement(join(19330..19404,19464..19548,19625..19707)) VI 1 NT_166520.1 Remark: the ORF has an intron-exon structure, which is not typical for A. niger proteins and is only 80 amino acids long.; Title: questionable ORF; uncharacterized protein 19707 84590587 An03g00090 Aspergillus niger uncharacterized protein XP_059600149.1 19330 R 5061 CDS An03g00100 84590588 complement(join(20071..20520,20612..20697,20972..21045,21076..21168,21219..21259,21446..21457)) VI 1 NT_166520.1 Remark: the intron-exon structure is suboptimal.; hypothetical protein 21457 84590588 An03g00100 Aspergillus niger hypothetical protein XP_059600150.1 20071 R 5061 CDS An03g00110 84590589 complement(join(22055..22126,22165..22388,22467..22509)) VI 1 NT_166520.1 hypothetical protein 22509 84590589 An03g00110 Aspergillus niger hypothetical protein XP_059600151.1 22055 R 5061 CDS An03g00120 84590590 join(22998..23285,23392..23536,23719..23726,23761..23827,23875..23988,24092..24156) VI 1 NT_166520.1 hypothetical protein 24156 84590590 An03g00120 Aspergillus niger hypothetical protein XP_059600152.1 22998 D 5061 CDS An03g00130 4980721 25331..26938 VI 1 NT_166520.1 Function: SDH of G. oxydans is able to convert D-sorbitol to 2-keto-L-gulonate (2-KLGA).; Similarity: the ORF overlaps with A. niger EST (EMBLEST:BE759914) an_2856.; Similarity: the ORF shows similarity to several oxidoreductases with different specificities, especially to choline dehydrogenases.; Title: strong similarity to FAD-dependent L-sorbose dehydrogenase SDH - Gluconobacter oxydans; uncharacterized protein 26938 4980721 An03g00130 Aspergillus niger uncharacterized protein XP_001389920.3 25331 D 5061 CDS An03g00140 4980709 complement(29431..30465) VI 1 NT_166520.1 Remark: the ORF shows similarity to several putative oxidoreductases from various species.; Title: strong similarity to hypothetical cytochrome P450 oxidoreductase - Streptomyces lividans; uncharacterized protein 30465 4980709 An03g00140 Aspergillus niger uncharacterized protein XP_001389921.1 29431 R 5061 CDS An03g00150 84590591 31563..32579 VI 1 NT_166520.1 hypothetical protein 32579 84590591 An03g00150 Aspergillus niger hypothetical protein XP_059600153.1 31563 D 5061 CDS An03g00160 4980692 complement(join(33004..33248,33307..33845,33949..34548,34614..35466,35982..36028,36115..36248)) VI 1 NT_166520.1 Function: the tamA gene of A. nidulans has a positive role together with areA in regulating the expression of genes subject to nitrogen metabolite repression.; Similarity: the ORF shows similarity to several transcription activators.; Title: strong similarity to transcription activator tamA - Aspergillus nidulans; nucleus; See PMID 8655534; See PMID 10471703; See PMID 11459183; See PMID 1105154; uncharacterized protein 36248 4980692 An03g00160 Aspergillus niger uncharacterized protein XP_059600154.1 33004 R 5061 CDS An03g00170 4980705 complement(join(36824..37731,37793..37885,37937..38246)) VI 1 NT_166520.1 Localization: mMCT2 from mouse was also expressed in a small subset of microtubule-associated protein-2-positive elements, indicating a neuronal localization.; Localization: strong immunoreactivity for mMCT2 transporter from mouse was found in glia limitans,ependymocytes and several microvessel-like elements.; Remark: monocarboxylic acids, i. e., lactate,pyruvate, and ketone bodies, can be utilized by the brain as alternative energy substrates.; Remark: the expression of the monocarboxylate transporters mMCT2 from M. musculus is limited, with high levels of expression confined to testes, kidney, stomach,and liver and lower levels in lung, brain, and epididymal fat.; Title: strong similarity to monocarboxylate transporter mMCT2 - Mus musculus; plasma membrane; See PMID 9725820; See PMID 11098125; uncharacterized protein 38246 4980705 An03g00170 Aspergillus niger uncharacterized protein XP_001389924.3 36824 R 5061 CDS An03g00180 4980712 complement(join(38672..38779,38947..39068,39146..40280)) VI 1 NT_166520.1 Catalytic activity: hydroxylation of n-alkanes at the terminal position.; Function: together with an NADPH cytochrome p450 the enzyme system catalyzes the terminal hydroxylation as the first step in the assimilation of alkanes and fatty acids.; Similarity: belongs to the cytochrome p450 family.; Title: strong similarity to cytochrome P450 alkane hydroxylase ALK2 - Debaryomyces hansenii; See PMID 9931473; uncharacterized protein 40280 4980712 An03g00180 Aspergillus niger uncharacterized protein XP_059600155.1 38672 R 5061 CDS An03g00190 4980695 complement(join(41589..41924,41982..42312,42369..42494,42551..42694,42754..42956)) VI 1 NT_166520.1 Function: Eliminative cleavage of pectin to give oligosaccharides with terminal 4-deoxy-6-methyl-alpha-D-galact-4-enuronosyl groups.; Gene-ID: pelB; Similarity: pelB is a member of the Aspergillus niger pectin lyase multigene family.; See PMID 9309173; See PMID 1495474; pectin lyase pelB-Aspergillus niger 42956 pelB 4980695 pelB Aspergillus niger pectin lyase pelB-Aspergillus niger XP_001389926.1 41589 R 5061 CDS An03g00200 4980702 join(44557..44875,44973..45208) VI 1 NT_166520.1 Title: weak similarity to NifA-regulated gene nrgA -Bradyrhizobium japonicum; uncharacterized protein 45208 4980702 An03g00200 Aspergillus niger uncharacterized protein XP_001389927.3 44557 D 5061 CDS An03g00210 4980725 complement(join(45264..45687,45754..45878)) VI 1 NT_166520.1 Title: similarity to hypothetical protein encoded by An16g01170 - Aspergillus niger; uncharacterized protein 45878 4980725 An03g00210 Aspergillus niger uncharacterized protein XP_001389928.3 45264 R 5061 CDS An03g00220 84590592 complement(join(46175..46285,46361..46564)) VI 1 NT_166520.1 hypothetical protein 46564 84590592 An03g00220 Aspergillus niger hypothetical protein XP_059600156.1 46175 R 5061 CDS An03g00230 4980708 join(47264..47398,47453..47523,47580..47693,47800..48263,48330..48353,48413..48738,48803..49237) VI 1 NT_166520.1 Function: gabA encodes the gamma-amino-n-butyrate (GABA) permease of the fungus A. nidulans.; Remark: transcript level analyses demonstrate that gabA from A. nidulans is subject to carbon catabolite and nitrogen metabolite repression.; Similarity: to other choline transport proteins.; Title: strong similarity to GABA permease gabA -Aspergillus nidulans; See PMID 10320578; uncharacterized protein 49237 4980708 An03g00230 Aspergillus niger uncharacterized protein XP_001389930.1 47264 D 5061 CDS An03g00240 4980703 complement(join(49505..50101,50162..51142,51197..51275,51342..51400,51465..51533)) VI 1 NT_166520.1 Title: weak similarity to filamentous muscle protein titin - Homo sapiens; uncharacterized protein 51533 4980703 An03g00240 Aspergillus niger uncharacterized protein XP_001389931.1 49505 R 5061 CDS An03g00250 4980694 complement(join(52428..52825,52900..53188)) VI 1 NT_166520.1 Function: Slg1 from S. cerevisiae is a cell surface sensor for cell integrity signaling in S. cerevisiae.; Function: the Slg1 protein from S. cerevisiae is proposed to play a regulatory role in bud emergence or stationary phase.; Phenotype: deletion of slg1 in S. cerevisiae results in cell lysis during growth at elevated temperatures.; Phenotype: deletion of slg1 in S. cerevisiae results in sensitivity against caffeine.; Remark: synonyms for Slg1 from S. cerevisiae are Hcs77, Wsc1 and YOR008c.; Title: strong similarity to protein equired for cell wall integrity Slg1 - Saccharomyces cerevisiae; plasma membrane; See PMID 9613583; See PMID 10660075; See PMID 11113201; uncharacterized protein 53188 4980694 An03g00250 Aspergillus niger uncharacterized protein XP_001389932.1 52428 R 5061 CDS An03g00260 84590593 join(54348..54630,54681..55091,55160..55563) VI 1 NT_166520.1 Title: similarity to hypothetical protein CAE47968.1 - Aspergillus fumigatus; uncharacterized protein 55563 84590593 An03g00260 Aspergillus niger uncharacterized protein XP_059600157.1 54348 D 5061 CDS An03g00270 84590594 complement(join(57290..57369,57526..57542,57574..57588,57959..58160,58383..58584)) VI 1 NT_166520.1 hypothetical protein 58584 84590594 An03g00270 Aspergillus niger hypothetical protein XP_059600158.1 57290 R 5061 CDS An03g00280 4980699 complement(join(58715..58975,59029..59305,59364..59629,59686..59848,59910..60094)) VI 1 NT_166520.1 Remark: The matched sequence represents a S. antibioticus tyrosinase and tyrosinase activator protein fusion enzyme.; Title: similarity to tyrosinase and tyrosinase activator protein fusion enzyme from patent WO9513386-A -Streptomyces antibioticus; uncharacterized protein 60094 4980699 An03g00280 Aspergillus niger uncharacterized protein XP_001389935.1 58715 R 5061 CDS An03g00290 4980718 join(61676..61882,61943..62168,62233..62379,62451..62568,62619..62687,62838..63171) VI 1 NT_166520.1 Function: pth11 mutants of M. grisea are nonpathogenic due to a defect in appressorium differentiation.; Localization: a M. grisea pth11-green fluorescent protein fusion localizes to the cell membrane and vacuoles.; Remark: Plant pathogenic fungi like M. grisea differentiate a highly specialized infection cell called an appressorium to infect their hosts.; Remark: pth11 from M. grisea mediates appressorium differentiation in response to inductive substrate cues.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529; uncharacterized protein 63171 4980718 An03g00290 Aspergillus niger uncharacterized protein XP_059600159.1 61676 D 5061 CDS An03g00300 84590595 63661..64932 VI 1 NT_166520.1 Title: weak similarity to megakaryocyte stimulating factor MSF from patent WO200064930-A2 - Homo sapiens; uncharacterized protein 64932 84590595 An03g00300 Aspergillus niger uncharacterized protein XP_059600160.1 63661 D 5061 CDS An03g00310 4980696 66318..67694 VI 1 NT_166520.1 Remark: the gene for rickettsial outer-membrane protein A (rOmpA)is a distinguishing feature of the spotted fever group (SFG) rickettsiae.; Title: similarity to rickettsial outer membrane protein A rOmpA - Rickettsia conorii; outer membrane; See PMID 9384303; See PMID 9734038; uncharacterized protein 67694 4980696 An03g00310 Aspergillus niger uncharacterized protein XP_001389938.1 66318 D 5061 CDS An03g00320 4980691 join(68600..68766,68828..69229,69290..70184) VI 1 NT_166520.1 Remark: the matched protein from A. chrysogenum is involved in biosynthesis of cephalosporin C.; Similarity: the ORF encoded protein shows also similarities to transport proteins.; Title: strong similarity to protein involved in cephalosporin C biosynthesis from patent JP09009966-A -Acremonium chrysogenum; uncharacterized protein 70184 4980691 An03g00320 Aspergillus niger uncharacterized protein XP_059600161.1 68600 D 5061 CDS An03g00330 10098126 complement(join(70866..71231,71340..71487,71766..71824)) VI 1 NT_166520.1 hypothetical protein 71824 10098126 An03g00330 Aspergillus niger hypothetical protein XP_059600162.1 70866 R 5061 CDS An03g00340 4980729 complement(join(71983..72010,72181..72352,72428..72755,72808..72924,72979..73059,73119..73283)) VI 1 NT_166520.1 Remark: ORF contains 1 frameshift, due to a putative sequencing errors.; Remark: The matched protein from C. glutamicum is used to maintain homeostasis in C. glutamicum or help the microorganism to adapt to different environmental conditions.; Title: strong similarity to protein sequence SEQ ID NO:426 from patent WO200100842-A2 - Corynebacterium glutamicum [putative sequencing error]; uncharacterized protein 73283 4980729 An03g00340 Aspergillus niger uncharacterized protein XP_059600163.1 71983 R 5061 CDS An03g00350 4980706 73650..74732 VI 1 NT_166520.1 Complex: the bphC enzyme from P. stutzeri is a homo-octamer.; Function: the protein bphC from P. stutzeri catalyzes the extradiol ring cleavage of 2,3-dihydroxybiphenyl as a key enzyme in the biphenyl/PCB (Poly Chlorinated Biphenyls) degradation.; Remark: bphC from P. stutzeri is an extradiol type catecholic dioxygenase, is a non-heam iron-containing enzyme.; Title: strong similarity to 3-dihydroxybiphenyl-1,2-dioxygenase bphC - Pseudomonas stutzeri; See PMID 9095556; See PMID 11293547; uncharacterized protein 74732 4980706 An03g00350 Aspergillus niger uncharacterized protein XP_059600164.1 73650 D 5061 CDS An03g00360 4980700 complement(74814..75980) VI 1 NT_166520.1 Remark: the matching coding sequence was isolated by RT-PCR on all of the mRNA from A. thaliana.; Remark: there are no further informations about the patent available.; Title: strong similarity to rotein fragment SEQ ID NO:34012 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 75980 4980700 An03g00360 Aspergillus niger uncharacterized protein XP_001389943.1 74814 R 5061 CDS An03g00370 4980728 join(76399..76700,76799..77864) VI 1 NT_166520.1 Induction: the expression of paxM from P. paxilli in submerged liquid cultures of P. paxilli increased dramatically with the onset of paxilline biosynthesis.; Remark: The indole-diterpene paxilline is a potent tremorgenic mammalian mycotoxin and a known inhibitor of maxi-K ion channels.; Remark: The indole-diterpene paxilline is synthezised by a gene cluster of 17 genes including the FAD-dependent monooxycenase paxM from P. paxilli.; Title: similarity to monooxygenase paxM -Penicillium paxilli; See PMID 11169115; uncharacterized protein 77864 4980728 An03g00370 Aspergillus niger uncharacterized protein XP_001389944.1 76399 D 5061 CDS An03g00380 4980723 join(78510..79010,79069..79461) VI 1 NT_166520.1 Remark: the matching coding sequence was isolated by RT-PCR on all of the mRNA from A. thaliana.; Remark: there are no further informations about the patent available.; Title: strong similarity to protein fragment SEQ ID NO:11222 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 79461 4980723 An03g00380 Aspergillus niger uncharacterized protein XP_001389946.3 78510 D 5061 CDS An03g00390 84590596 80643..81530 VI 1 NT_166520.1 Title: weak similarity to immunoglobulin binding factor activity IBF from patent EP155192-A - Mus musculus; uncharacterized protein 81530 84590596 An03g00390 Aspergillus niger uncharacterized protein XP_059600165.1 80643 D 5061 CDS An03g00400 4980710 complement(82784..83791) VI 1 NT_166520.1 Complex: Hsp42 from S. cerevisiae multimerizes with itself .; Function: S. cerevisiae hsp42 mutants which are subjected to moderate thermal stress reorganized the actin cytoskeleton more slowly than wild-type cells.; Remark: the synonym for Hsp42 from S. cerevisiae is YDR171w.; Title: similarity to heat shock protein Hsp42 -Saccharomyces cerevisiae; See PMID 8576246; See PMID 9199338; uncharacterized protein 83791 4980710 An03g00400 Aspergillus niger uncharacterized protein XP_001389947.1 82784 R 5061 CDS An03g00410 4980688 join(84988..85078,85162..86069,86122..86248,86303..86422,86474..86838) VI 1 NT_166520.1 Function: glutaminyl-tRNA can be formed by direct acylation by glutaminyl-tRNA synthetase or alternatively by transamidation of incorrectly charged tRNA by the Glutamyl-tRNA(Gln) amidotransferase.; Function: may be involved in biosynthesis of asparagine in the asparagine prototroph D. radiodurans.; Title: strong similarity to glutamyl-tRNA(Gln) amidotransferase subunit A - Deinococcus radiodurans; See PMID 9789001; uncharacterized protein 86838 4980688 An03g00410 Aspergillus niger uncharacterized protein XP_001389948.3 84988 D 5061 CDS An03g00420 4980690 complement(join(87033..87400,87467..87534,87588..87730,87782..88006,88065..88169,88226..88405)) VI 1 NT_166520.1 Title: similarity to hypothetical integral membrane protein pth11 like hypothetical protein CAC28570.2 -Neurospora crassa; uncharacterized protein 88405 4980690 An03g00420 Aspergillus niger uncharacterized protein XP_001389949.1 87033 R 5061 CDS An03g00430 4980738 join(89401..89545,89609..89769,89800..89914,90096..90413,90467..91251) VI 1 NT_166520.1 Remark: a fumonisin esterase enzyme with at least one fumonisin degradative enzyme is for example useful for detoxifying fumonisin or a structurally related mycotoxin present in harvested grain.; Remark: fumonisins are highly toxic to certain livestock and are potential carcinogens.; Remark: the matched sequence encodes a permease involved in fumonisin degradation.; Title: strong similarity to permease involved in fumonisin degradation from patent WO200105980-A1 -Exophiala spinifera; plasma membrane; uncharacterized protein 91251 4980738 An03g00430 Aspergillus niger uncharacterized protein XP_059600166.1 89401 D 5061 CDS An03g00450 4980731 92689..93441 VI 1 NT_166520.1 Catalytic activity: Acetoacetate + H+ = Acetone + CO2.; Complex: adc from C. acetobutylicum forms a homododecamer.; Induction: the expression of adc from C. acetobutylicum is induced by linear fatty acids (up to butyrate).; Title: similarity to acetoacetate decarboxylase adc - Clostridium acetobutylicum; See PMID 8226639; See PMID 2268159; uncharacterized protein 93441 4980731 An03g00450 Aspergillus niger uncharacterized protein XP_001389951.1 92689 D 5061 CDS An03g00460 4980732 complement(join(93795..95042,95149..95403)) VI 1 NT_166520.1 Catalytic activity: (R)-6-Hydroxynicotine + H2O + O2 = 1-(6-Hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H2O2.; Cofactor: FAD flavoprotein.; Pathway: degradation of nicotine (inducible).; Remark: The expression of enzymatically active 6-HDNO from A. oxidans requires the covalent attachment of FAD to the polypeptide chain and phosphoenolpyruvate.; Title: strong similarity to 6-hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 3622516; See PMID 2680607; See PMID 3036509; See PMID 3056722; uncharacterized protein 95403 4980732 An03g00460 Aspergillus niger uncharacterized protein XP_001389952.1 93795 R 5061 CDS An03g00470 4980733 join(96294..96473,96539..96820,96879..96951,97022..97251,97351..97782) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein EAA48619.1 - Magnaporthe grisea; uncharacterized protein 97782 4980733 An03g00470 Aspergillus niger uncharacterized protein XP_059600167.1 96294 D 5061 CDS An03g00480 4980734 complement(join(98602..100280,100334..100592)) VI 1 NT_166520.1 Catalytic activity: Catalytic activity: 2-Acetolactate + CO2 = 2 Pyruvate.; Cofactor: FAD, thiamine pyrophosphate and magnesium ion.; Function: the ilv1 from S. pombe was shown to encode a functional subunit of acetolactate synthase by complementation of an S. cerevisiae strain deleted for the ILV2 locus.; Pathway: ilv1 from S. pombe catalyzes the first step in valine and isoleucine biosynthesis.; Title: strong similarity to acetolactate synthase ilv1p - Schizosaccharomyces pombe; localisation:mitochondrion; See PMID 8299177; uncharacterized protein 100592 4980734 An03g00480 Aspergillus niger uncharacterized protein XP_001389954.3 98602 R 5061 CDS An03g00490 4980735 join(101233..101242,101343..102292) VI 1 NT_166520.1 Catalytic activity: (S)-2-Hydroxy-2-methyl-3-oxobutanoate = (R)-2-Acetoin + CO2.; Remark: a B. subtilis strain harboring the aldB gene from B. brevis on a recombinant plasmid processed and secreted the alpha-acetolactate decarboxylase aldB.; Title: strong similarity to alpha-acetolactate decarboxylase aldB - Bacillus brevis; See PMID 2198252; uncharacterized protein 102292 4980735 An03g00490 Aspergillus niger uncharacterized protein XP_001389955.3 101233 D 5061 CDS An03g00500 4980736 complement(join(102859..103457,103520..104387)) VI 1 NT_166520.1 Function: the matched protein from A. fumigatus is related to a enzyme of microbial origin which cleaves disaccharide glycosides, in particular beta-primeveroside.; Title: strong similarity to diglycosidase related protein SEQ ID NO:10 from patent WO200018931-A1 -Aspergillus fumigatus; uncharacterized protein 104387 4980736 An03g00500 Aspergillus niger uncharacterized protein XP_059600168.1 102859 R 5061 CDS An03g00520 84590597 join(105583..105883,105952..107489) VI 1 NT_166520.1 hypothetical protein 107489 84590597 An03g00520 Aspergillus niger hypothetical protein XP_059600169.1 105583 D 5061 CDS An03g00530 84590598 complement(join(108512..108859,108938..109132,109188..109239,109296..109846,109896..109907)) VI 1 NT_166520.1 Catalytic activity: salicylate hydroxylases converts Salicylate + NADH + O2 = Catechol + NAD+ + H2O + CO2.; Function: NahW of P. stutzeri exhibits a broad substrate specificities and metabolize salicylate,methylsalicylates, and chlorosalicylates.; Pathway: NahW of P. stutzeri is involved in the metabolization of naphtalene and salicylates (lower naphtalene degradation pathway).; Remark: in P. stutzeri exist two independent salicylate hydroxylases nahG and nahW, both are in involved in naphthalene degradation, but are not located in the same transcription unit.; Title: similarity to salicylate hydroxylase nahW -Pseudomonas stutzeri; See PMID 10197990; uncharacterized protein 109907 84590598 An03g00530 Aspergillus niger uncharacterized protein XP_059600170.1 108512 R 5061 CDS An03g00540 84590599 complement(join(110377..110398,110486..110551,110584..110594)) VI 1 NT_166520.1 Title: questionable ORF; uncharacterized protein 110594 84590599 An03g00540 Aspergillus niger uncharacterized protein XP_059600171.1 110377 R 5061 CDS An03g00550 4980043 111660..112322 VI 1 NT_166520.1 Title: strong similarity to hypothetical protein encoded by An03g00560 - Aspergillus niger; uncharacterized protein 112322 4980043 An03g00550 Aspergillus niger uncharacterized protein XP_001389960.1 111660 D 5061 CDS An03g00560 4980044 join(112955..113558,113733..113770) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein encoded by An03g00550 - Aspergillus niger; uncharacterized protein 113770 4980044 An03g00560 Aspergillus niger uncharacterized protein XP_001389961.3 112955 D 5061 CDS An03g00580 4980046 complement(116064..117665) VI 1 NT_166520.1 Function: eln2 of C. cinereus encodes a novel type of microsomal cytochrome P450 enzyme, which is involved in mushroom morphogenesis.; Localization: C. cinereus eln2 localises to the microsomal compartment.; Phenotype: a dominant mutation of the elongationless2 (eln2) gene of the mushroom C. cinereus affects pattern formation in the development of fruit body primordia, causing dumpy primordia which culminate in mature fruit bodies with short stipes.; Similarity: the ORF shows similarity to several cytochrome p450 related proteins from different species,which have different cellular functions.; Title: strong similarity to cytochrome P450 protein eln2 SEQ ID NO:1 from patent JP2000152788-A - Coprinus cinereus; See PMID 10779399; uncharacterized protein 117665 4980046 An03g00580 Aspergillus niger uncharacterized protein XP_001389962.1 116064 R 5061 CDS An03g00590 4980047 join(118823..118825,118885..120027) VI 1 NT_166520.1 Catalytic activity: 2-trans,6-trans-farnesyl diphosphate = trichodiene + diphosphate.; Function: Tri5 of G. zeae encodes the first enzyme in the trichothecene biosynthetic pathway, the trichodiene synthase.; Pathway: the trichodiene synthase Tri5 from G. zeae is involved in the Terpenoid biosynthesis.; Phenotype: Reduced virulence of G. zeae is caused by disruption of the trichothecene toxin biosynthetic gene encoding trichodiene synthase Tri5.; Phenotype: trichothecene production is disabled by specific disruption of the trichodiene synthase gene Tri5 of G. zeae.; Title: strong similarity to trichodiene synthase Tri5 - Gibberella zeae; See PMID 8589414; See PMID 9274012; See PMID 10931910; See PMID 11425709; uncharacterized protein 120027 4980047 An03g00590 Aspergillus niger uncharacterized protein XP_001389963.3 118823 D 5061 CDS An03g00600 4980048 complement(120814..121863) VI 1 NT_166520.1 Title: weak similarity to mitogen ERK kinase kinase MEKK-2 from patent US5981265-A - Homo sapiens; uncharacterized protein 121863 4980048 An03g00600 Aspergillus niger uncharacterized protein XP_001389964.1 120814 R 5061 CDS An03g00610 84590600 join(122336..122351,122432..122586) VI 1 NT_166520.1 Title: similarity to hypothetical protein encoded by An06g00610 - Aspergillus niger; uncharacterized protein 122586 84590600 An03g00610 Aspergillus niger uncharacterized protein XP_059600172.1 122336 D 5061 CDS An03g00620 84590601 join(124631..124716,124926..125019,125066..125281) VI 1 NT_166520.1 Title: weak similarity to semaphorin Y from patent WO9811216-A1 - Rattus norvegicus; uncharacterized protein 125281 84590601 An03g00620 Aspergillus niger uncharacterized protein XP_059600173.1 124631 D 5061 CDS An03g00630 84590602 complement(join(125341..125441,125796..125898,126044..126077,126171..126364,126449..126496)) VI 1 NT_166520.1 hypothetical protein 126496 84590602 An03g00630 Aspergillus niger hypothetical protein XP_059600174.1 125341 R 5061 CDS An03g00640 4980052 join(<126874..127034,127107..127514,127568..127737,127796..127923,127981..128095,128151..128656) VI 1 NT_166520.1 Function: mtr of N. crassa is required for the transport of neutral aliphatic and aromatic amino acids.; Similarity: mtr of N. crassa belongs to the Amino Acid/Auxin Permease (AAAP) family.; Title: similarity to neutral amino acid permease mtr - Neurospora crassa [truncated ORF]; plasma membrane; See PMID 1838345; See PMID 8001794; uncharacterized protein 128656 4980052 An03g00640 Aspergillus niger uncharacterized protein XP_001389968.3 126874 D 5061 CDS An03g00650 4980053 complement(128912..135718) VI 1 NT_166520.1 Function: AM-toxin of A. alternata is a cyclic peptide host-specific toxin.; Phenotype: disruption of AM-toxin synthetase (AMT) resulted in toxin-minus mutants.; Similarity: the A. niger protein shows similarity to other fungal peptide synthetases.; Title: similarity to cyclic peptide AM-toxin synthase AMT - Alternaria alternata; See PMID 10875335; uncharacterized protein 135718 4980053 An03g00650 Aspergillus niger uncharacterized protein XP_001389969.1 128912 R 5061 CDS An03g00660 4980054 join(136212..136346,136432..137164,137229..137479) VI 1 NT_166520.1 Catalytic activity: taurine + 2-oxoglutarate + O2 = sulfite + aminoacetaldehyde + succinate + CO2.; Remark: taurine/alpha-ketoglutarate dioxygenase (TauD), a member of the broad class of non-heme Fe(II) oxygenases, converts taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde while decomposing alpha-ketoglutarate (alphaKG) to form succinate and CO(2).; Remark: the Escherichia coli tauD gene is required for the utilization of taurine (2-aminoethanesulfonic acid) as a sulfur source and is expressed only under conditions of sulfate starvation.; Title: similarity to taurine dioxygenase tauD -Escherichia coli; See PMID 9287300; See PMID 10563813; uncharacterized protein 137479 4980054 An03g00660 Aspergillus niger uncharacterized protein XP_001389970.1 136212 D 5061 CDS An03g00670 4980055 complement(138397..139551) VI 1 NT_166520.1 Function: nos of A. tumefaciens catalyzes the formation of nopaline by the reductive condensation of alpha-ketoglutaric acid and arginine.; Function: nos of A. tumefaciens is involved in the induction of tumors (crown gall) in dicotyledonous plants.; Title: similarity to D-nopaline dehydrogenase nos -Agrobacterium tumefaciens; See PMID 476084; See PMID 7153689; uncharacterized protein 139551 4980055 An03g00670 Aspergillus niger uncharacterized protein XP_001389971.1 138397 R 5061 CDS An03g00680 4980056 join(140374..140569,140740..142211) VI 1 NT_166520.1 Function: multidrug transporter are active in the efflux of a varity of (often cytotoxic) compounds, e. g. fnx1 of S. pombe possibly releases a signaling substance into the environment, which could be required for entry of the cell into the quiescent G0 state.; Similarity: the predicted ORF shows similarity to multidrug transporter from different species and with various specificity.; Title: strong similarity to multidrug resistance protein fnx1p - Schizosaccharomyces pombe; uncharacterized protein 142211 4980056 An03g00680 Aspergillus niger uncharacterized protein XP_059600175.1 140374 D 5061 CDS An03g00690 4980057 join(142820..142825,142909..143076) VI 1 NT_166520.1 hypothetical protein 143076 4980057 An03g00690 Aspergillus niger hypothetical protein XP_001389973.1 142820 D 5061 CDS An03g00700 84590603 join(144314..144356,144511..144611,144740..144817) VI 1 NT_166520.1 hypothetical protein 144817 84590603 An03g00700 Aspergillus niger hypothetical protein XP_059600176.1 144314 D 5061 CDS An03g00720 4980060 complement(join(145654..145787,145860..145890)) VI 1 NT_166520.1 Title: strong similarity to EST SEQ ID NO:4295 from patent WO200056762-A2 - Aspergillus niger; uncharacterized protein 145890 4980060 An03g00720 Aspergillus niger uncharacterized protein XP_001389975.1 145654 R 5061 CDS An03g00730 4980061 complement(join(146356..146561,146629..147540,147613..148192,148253..148561)) VI 1 NT_166520.1 Catalytic activity: AO-I catalyses formation of hydrogen peroxide from butyl amine, or benzylamine by oxidative deamination. RCH(2)NH(2) + H(2)O + O(2) <=> RCHO + NH(3) + H(2)O(2).; Function: the A. niger homolog AO-I is located in the cell wall and may function as detoxifying agent,preventing amines from entering and damaging the cell.; Induction: A. niger AO-I is highly expressed in cells grown on n-butylamine as a single nitrogen source.; Title: strong similarity to copper amine oxidase AO-I from patent JP08070872-A - Aspergillus niger; cell wall; uncharacterized protein 148561 4980061 An03g00730 Aspergillus niger uncharacterized protein XP_001389976.1 146356 R 5061 CDS An03g00740 4980062 complement(join(148981..149559,149620..150362,150394..150520,150746..150760)) VI 1 NT_166520.1 Remark: alternate name for S. cerevisiae Dcw1 is YKL046c.; Title: strong similarity to hypothetical protein Dcw1 - Saccharomyces cerevisiae; uncharacterized protein 150760 4980062 An03g00740 Aspergillus niger uncharacterized protein XP_059600177.1 148981 R 5061 CDS An03g00750 4980063 join(151153..151164,151389..151445,151484..151626,151681..151796,151847..151981,152030..152574,152619..152892,152938..153113,153161..153344,153397..153932) VI 1 NT_166520.1 Function: The Aspergillus nidulans homolog prnA is a transcriptional activator that mediates proline induction of four other genes involved in proline utilization as a nitrogen and/or carbon source.; Induction: The transcription of the A. nidulans prnA is neither self-regulated nor significantly affected by carbon and/or nitrogen metabolite repression.; Title: strong similarity to transcription activator prnA - Aspergillus nidulans; nucleus; See PMID 9622360; uncharacterized protein 153932 4980063 An03g00750 Aspergillus niger uncharacterized protein XP_059600178.1 151153 D 5061 CDS An03g00760 84590604 complement(join(155088..155138,155531..155576,155662..155799,156014..156216,156383..156604)) VI 1 NT_166520.1 hypothetical protein 156604 84590604 An03g00760 Aspergillus niger hypothetical protein XP_059600179.1 155088 R 5061 CDS An03g00770 4980065 156933..158054 VI 1 NT_166520.1 Remark: The Aspergillus fumigatus homolog rAsp f 4 is a non-secreted protein of unknown function and is related to allergic bronchopulmonary aspergillosis (ABPA) in human.; Title: strong similarity to hypothetical allergic bronchopulmonary aspergillosis allergen rAsp f 4 from patent WO9828624-A1 - Aspergillus fumigatus; uncharacterized protein 158054 4980065 An03g00770 Aspergillus niger uncharacterized protein XP_001389980.1 156933 D 5061 CDS An03g00790 4980067 complement(join(159723..159961,160012..160237)) VI 1 NT_166520.1 Catalytic activity: E. coli rnc performs an endonucleolytic cleavage to 5'-phosphomonoester.; Function: E. coli homolog rnc is a endoribonuclease specific for double stranded RNA.; Function: E. coli rnc is involved in processing and maturation of ribosomal and tRNAs and participates in regulation of mRNA stability and stimulation of translation.; Title: similarity to ribonuclease III rnc -Escherichia coli; uncharacterized protein 160237 4980067 An03g00790 Aspergillus niger uncharacterized protein XP_001389981.1 159723 R 5061 CDS An03g00800 84590605 join(160865..160939,161082..161338,161434..161518) VI 1 NT_166520.1 hypothetical protein 161518 84590605 An03g00800 Aspergillus niger hypothetical protein XP_059600180.1 160865 D 5061 CDS An03g00810 84590606 complement(join(161780..161796,161902..162025)) VI 1 NT_166520.1 hypothetical protein 162025 84590606 An03g00810 Aspergillus niger hypothetical protein XP_059600181.1 161780 R 5061 CDS An03g00820 84590607 join(162277..162321,162430..162603,162924..162977,163363..163659) VI 1 NT_166520.1 hypothetical protein 163659 84590607 An03g00820 Aspergillus niger hypothetical protein XP_059600182.1 162277 D 5061 CDS An03g00830 84590608 complement(164268..165443) VI 1 NT_166520.1 Similarity: similar to a repetitive element in H. sapiens MUC2 and other mucins of approximately 350 amino acids.; Title: weak similarity to intestinal mucin MUC2 -Homo sapiens; uncharacterized protein 165443 84590608 An03g00830 Aspergillus niger uncharacterized protein XP_059600183.1 164268 R 5061 CDS An03g00840 84590609 165894..167903 VI 1 NT_166520.1 Remark: blastp matches are unspecific.; Title: strong similarity to EST an_3113 -Aspergillus niger; uncharacterized protein 167903 84590609 An03g00840 Aspergillus niger uncharacterized protein XP_059600184.1 165894 D 5061 CDS An03g00850 4980073 join(169439..169765,169820..170172,170228..170555) VI 1 NT_166520.1 Pathway: paxC of P. paxilli is part of a gene cluster involved in the synthesis of indole-diterpene paxilline, a potent tremorgenic mammalian mycotoxin and a known inhibitor of maxi-K ion channels.; Remark: the A. niger protein contains BLOCKS and PFAM domains corresponding to polypreny synthetase.; Remark: the adjacent A. niger ORF shows similarity to paxG of P. paxilli that is also involved in the synthesis of indole-diterpene paxilline.; Remark: the molecular function of paxC has not been described.; Title: strong similarity to hypothetical prenyl transferase paxC - Penicillium paxilli; uncharacterized protein 170555 4980073 An03g00850 Aspergillus niger uncharacterized protein XP_001389987.1 169439 D 5061 CDS An03g00860 4980074 join(171299..171472,171523..171677,171747..172079,172141..172519) VI 1 NT_166520.1 Catalytic activity: farnesyltranstransferases catalyse the reaction trans-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.; Pathway: paxG of P. paxilli is involved in the synthesis of indole-diterpene paxilline, a potent tremorgenic mammalian mycotoxin and a known inhibitor of maxi-K ion channels.; Similarity: the predicted protein of A. niger shows similarity to geranylgeranyl diphosphate synthases, which are officially named farnesyltranstransferases.; Title: strong similarity to geranylgeranyl pyrophosphate synthase paxG - Penicillium paxilli; See PMID 11169115; uncharacterized protein 172519 4980074 An03g00860 Aspergillus niger uncharacterized protein XP_059600185.1 171299 D 5061 CDS An03g00870 4980075 join(172881..173059,173275..173334,173517..175086,175221..175340) VI 1 NT_166520.1 Similarity: the predicted A. niger protein is similar to putative zinc finger proteins of the Kruppel type.; Title: strong similarity to hypothetical protein encoded by An12g10520 - Aspergillus niger; uncharacterized protein 175340 4980075 An03g00870 Aspergillus niger uncharacterized protein XP_059600186.1 172881 D 5061 CDS An03g00880 4980076 join(175841..176681,176719..176723) VI 1 NT_166520.1 Title: similarity to hypothetical 2-dehydropantoate 2-reductase - Schizosaccharomyces pombe; uncharacterized protein 176723 4980076 An03g00880 Aspergillus niger uncharacterized protein XP_059600187.1 175841 D 5061 CDS An03g00890 4980077 complement(join(177101..177706,177760..177907,177962..178212,178254..178340)) VI 1 NT_166520.1 Complex: krd of Z. rouxii exists as a monomer.; Function: ketoreductase of Z. rouxii catalyzes the asymmetric reduction of selected ketone substrates of commercial importance, like alpha-ketolactones,alpha-ketolactams, and diketones.; Remark: substrate specificity, lack of a catalytic metal, and extent of protein sequence identity to known reductases suggests that the enzyme falls into the carbonyl reductase enzyme class.; Remark: the protein sequence of ketoreductase of Z. rouxii is covered by patent EP918090-A2 (AC# AAY05769).; Title: strong similarity to ketoreductase krd -Zygosaccharomyces rouxii; See PMID 10951208; uncharacterized protein 178340 4980077 An03g00890 Aspergillus niger uncharacterized protein XP_059600188.1 177101 R 5061 CDS An03g00900 4980078 complement(join(178549..178710,178775..179048,179107..179114)) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein SC6A5.32c - Streptomyces coelicolor; uncharacterized protein 179114 4980078 An03g00900 Aspergillus niger uncharacterized protein XP_001389992.1 178549 R 5061 CDS An03g00910 4980079 complement(join(180047..181135,181189..181362)) VI 1 NT_166520.1 Remark: the patent does not give additional information about the function of the protein.; Title: strong similarity to sequence 385 from patent WO0100842-A - Corynebacterium glutamicum; uncharacterized protein 181362 4980079 An03g00910 Aspergillus niger uncharacterized protein XP_001389993.1 180047 R 5061 CDS An03g00920 4980080 join(182165..182195,182249..183474) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein SPCC757.02c - Schizosaccharomyces pombe; uncharacterized protein 183474 4980080 An03g00920 Aspergillus niger uncharacterized protein XP_001389994.1 182165 D 5061 CDS An03g00930 84590610 join(183553..183571,183617..183713,183790..183877,183944..184006) VI 1 NT_166520.1 Remark: the ORF is short in length (88 amino acids).; hypothetical protein 184006 84590610 An03g00930 Aspergillus niger hypothetical protein XP_059600189.1 183553 D 5061 CDS An03g00940 4980082 complement(join(184694..184783,184844..184909,184972..185062,185115..185160,185216..185304,185358..185503,185556..185677,185739..185787,185847..185887,185944..186187)) VI 1 NT_166520.1 Catalytic activity: endo-1,4-beta-xylanase A of A. niger hydrolyses 1,4-beta-D-xylosidic linkages in xylans,which are the major constituent of plant hemicellulose.; Gene-ID: xynA; Remark: due to the complex composition of xylan, a spectrum of enzyme activities is necessary for the complete hydrolysis of this polysaccharide. endo-xylanases (E. C. 3. 2. 1. 8) are only capable of hydrolysing the xylan backbone at non-modified residues. therefore microorganisms synthesize a number of enzymes capable of removing substituents from the xylan backbone, e. g. a-L-arabinofuranosidase B (ABFB)(E. C. 3. 2. 1. 55), acetyl xylan esterase (AXEA) (E. C. 3. 1. 1. 6) and (1,4)-b-D-arabinoxylan arabinofuranohydrolase (AXHA). these enzymes,which were all identified in various Aspergillus species,show strong synergistic effects with endo-xylanase activity resulting in an enhanced degradation of xylan.; Similarity: the predicted A. niger protein is 100% identical to the translated protein sequence of patent WO9713853-A/7 (AC# A62445). however, splice donor (AT) and acceptor (AC) sites of the 8th intron do not fit the consensus sequences of intron boundaries, which are GT and AG, respectively.; extracellular/secretion proteins; See PMID 8948110; See PMID 10422261; See PMID 10833405; endo-1,4-beta-xylanase A precursor xynA-Aspergillus niger [putative sequencing error] 186187 xynA 4980082 xynA Aspergillus niger endo-1,4-beta-xylanase A precursor xynA-Aspergillus niger [putative sequencing error] XP_059600190.1 184694 R 5061 CDS An03g00950 84590611 complement(join(186677..186806,186840..186943)) VI 1 NT_166520.1 hypothetical protein 186943 84590611 An03g00950 Aspergillus niger hypothetical protein XP_059600191.1 186677 R 5061 CDS An03g00960 4980084 187532..188530 VI 1 NT_166520.1 Catalytic activity: AXHA of A. niger hydrolyses terminal non-reducing alpha-l-arabinofuranoside residues in alpha-l-arabinosides.; Function: AXHA of A. niger releases 1,2-a- and 1,3-a- linked arabinofuranosyl groups from arabinoxylans and arabinoxylan-derived oligosaccharides but not from other arabinose-containing substrates such as arabinans and arabinogalactans.; Gene-ID: axhA; Remark: due to the complex composition of xylan, a spectrum of enzyme activities is necessary for the complete hydrolysis of this polysaccharide. endo-xylanases (E. C. 3. 2. 1. 8) are only capable of hydrolysing the xylan backbone at non-modified residues. therefore microorganisms synthesize a number of enzymes capable of removing substituents from the xylan backbone, e. g. a-L-arabinofuranosidase B (ABFB)(E. C. 3. 2. 1. 55), acetyl xylan esterase (AXEA) (E. C. 3. 1. 1. 6) and (1,4)-b-D-arabinoxylan arabinofuranohydrolase (AXHA). these enzymes,which were all identified in various Aspergillus species,show strong synergistic effects with endo-xylanase activity resulting in an enhanced degradation of xylan.; Similarity: (1,4)-beta-D-arabinoxylan arabinofuranohydrolase (axhA) of A. niger belongs to family 62 of glycosyl hydrolases.; extracellular/secretion proteins; See PMID 9000377; 1,4-beta-D-arabinoxylan arabinofuranohydrolase axhA-Aspergillus niger 188530 axhA 4980084 axhA Aspergillus niger 1,4-beta-D-arabinoxylan arabinofuranohydrolase axhA-Aspergillus niger XP_001389998.1 187532 D 5061 CDS An03g00970 4980085 join(188942..189379,189419..191266) VI 1 NT_166520.1 Similarity: similarity of the predicted A. niger protein to various protein sequences is due to low complexity sequences.; Title: strong similarity to hypothetical protein encoded by An08g12110 - Aspergillus niger; uncharacterized protein 191266 4980085 An03g00970 Aspergillus niger uncharacterized protein XP_059600192.1 188942 D 5061 CDS An03g00980 4980086 complement(192006..192833) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein CAD70785.1 - Neurospora crassa; uncharacterized protein 192833 4980086 An03g00980 Aspergillus niger uncharacterized protein XP_001390000.1 192006 R 5061 CDS An03g00990 84590612 complement(join(192966..193037,193111..193260,193561..193804,194071..194268,194361..194490,194570..194594)) VI 1 NT_166520.1 Remark: the ORF has an unusual intron/exon structure for A. niger.; hypothetical protein 194594 84590612 An03g00990 Aspergillus niger hypothetical protein XP_059600193.1 192966 R 5061 CDS An03g01000 4980088 join(195446..195509,195641..195825,195877..195913,195963..196422,196480..196840) VI 1 NT_166520.1 Function: M. grisea Pth11 is a pathogenicity gene.; Function: M. grisea Pth11p likely is involved in host surface recognition.; Function: M. grisea pth11 mutants of strain 4091-5-8 are nonpathogenic due to a defect in appressorium differentiation.; Localization: in M. grisea, a Pth11-green fluorescent protein fusion localised to the cell membrane and vacuoles.; Similarity: similarity of the predicted A. niger protein and M. grisea Pth11 is limited to the N-terminal half of the protein sequences.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529; uncharacterized protein 196840 4980088 An03g01000 Aspergillus niger uncharacterized protein XP_059600194.1 195446 D 5061 CDS An03g01010 4980089 complement(join(197246..197318,197374..197516,197571..198202,198256..198346,198393..198510,198560..199021,199074..199337,199429..199640)) VI 1 NT_166520.1 Catalytic activity: CLN2 of H. sapiens releases an N-terminal tripeptide from a polypeptide.; Remark: a partial protein sequence of CLN2 of H. sapiens, described as lung cancer associated polypeptide sequence SEQ ID 618, is covered by patent WO200055180-A2 (AC# AAB58280).; Remark: defects in CLN2 are the cause of classical late-infantile neuronal ceroid lipofuscinosis (lincl) (also known as ceroid lipofuscinosis neuronal 2; cln2).; Similarity: the predicted A. niger protein shows similarity to the lysosomal pepstatin insensitive protease (CLN2) of H. sapiens and other mammalians, which belong to the peptidase family S53.; Title: strong similarity to lysosomal pepstatin insensitive protease CLN2 - Homo sapiens; See PMID 9295267; uncharacterized protein 199640 4980089 An03g01010 Aspergillus niger uncharacterized protein XP_001390003.1 197246 R 5061 CDS An03g01020 84590613 complement(join(200043..200176,200218..200389)) VI 1 NT_166520.1 hypothetical protein 200389 84590613 An03g01020 Aspergillus niger hypothetical protein XP_059600195.1 200043 R 5061 CDS An03g01030 4980091 complement(join(200573..200816,200872..201625,201700..201910,201968..202156)) VI 1 NT_166520.1 Catalytic activity: 6-HDNO of A. oxidans catalyses the reaction (D)-6-hydroxynicotine + H(2)O + O(2) = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H(2)O(2).; Cofactor: 6-HDNO of A. oxidans requires the covalently bound cofactor FAD.; Induction: 6-HDNO of A. oxidans is induced by nicotine.; Pathway: 6-HDNO of A. oxidans is involved in the degradation of nicotine.; Remark: coinduced in the presence of nicotine is a 6-hydroxy-L-nicotine-specific enzyme, 6-hydroxy-L-nicotine oxidase (6-HLNO), with FAD noncovalently bound to the apoprotein. the two enantiozymes are genetically unrelated.; Similarity: the predicted A. niger protein shows similarity to 6-hydroxy-D-nicotine oxidase (6-HDNO) of A. oxidans and other oxygen oxidoreductases that covalently bind FAD.; Title: similarity to 6-hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 3622516; See PMID 2115879; See PMID 2680607; uncharacterized protein 202156 4980091 An03g01030 Aspergillus niger uncharacterized protein XP_001390005.3 200573 R 5061 CDS An03g01040 84590614 join(202214..202285,202413..202488,202575..202700,202796..202954,203042..203106,203156..203217,203312..203455,203537..203735) VI 1 NT_166520.1 hypothetical protein 203735 84590614 An03g01040 Aspergillus niger hypothetical protein XP_059600196.1 202214 D 5061 CDS An03g01050 4980093 join(204486..204893,204950..205123,205204..205771,205848..205932,206067..206112) VI 1 NT_166520.1 Catalytic activity: endo-beta-1,4-glucanase of B. polymyxa endohydrolyses 1,4-beta-D-glucosidic linkages in cellulose.; Pathway: endo-beta-1,4-glucanase of B. polymyxa is involved in starch and sucrose metabolism.; Similarity: the predicted A. niger protein shows strong similarity to A. thaliana hypothetical proteins and is similar to endo-beta-1,4-glucanase of B. polymyxa which belongs to cellulase family A (family 5 of glycosyl hydrolases).; Title: similarity to endo-beta-1,4-glucanase -Bacillus polymyxa; See PMID 2307659; uncharacterized protein 206112 4980093 An03g01050 Aspergillus niger uncharacterized protein XP_059600197.1 204486 D 5061 CDS An03g01060 4980094 complement(join(206577..206679,206747..206825,206900..207068)) VI 1 NT_166520.1 hypothetical protein 207068 4980094 An03g01060 Aspergillus niger hypothetical protein XP_001390008.1 206577 R 5061 CDS An03g01070 84590615 complement(join(207433..207576,207671..207697,207748..207824,208225..208344,208651..208678)) VI 1 NT_166520.1 Title: questionable ORF; uncharacterized protein 208678 84590615 An03g01070 Aspergillus niger uncharacterized protein XP_059600198.1 207433 R 5061 CDS An03g01080 84590616 join(210045..210273,210323..210465) VI 1 NT_166520.1 hypothetical protein 210465 84590616 An03g01080 Aspergillus niger hypothetical protein XP_059600199.1 210045 D 5061 CDS An03g01090 4980097 complement(join(211024..211210,211272..211777,211830..212209,212271..212439)) VI 1 NT_166520.1 Golgi; Phenotype: disruption of HOC1 resulted in hypersensitivity to Calcofluor White and hygromycin B,phenotypes characteristic of defects in cell wall integrity and protein glycosylation, respectively.; Remark: HOC1 of S. cerevisiae is a component of the protein complex in the cis Golgi, that is involved in the elongation the mannan backbone of N-linked glycans of cell wall.; Remark: HOC1 of S. cerevisiae was identified by its ability to suppress the cell lysis phenotype of pkc1-371 cells, that are defective in a protein kinase C isozyme.; Similarity: the predicted A. niger protein shows similarity to HOC1 (homologous to OCH1) of S. cerevisiae,which is similar to alpha-1,6-mannosyltransferase (OCH1) of S. cerevisiae.; Title: similarity to alpha-1,6-mannosyltransferase Hoc1 - Saccharomyces cerevisiae; See PMID 9055074; See PMID 10037752; uncharacterized protein 212439 4980097 An03g01090 Aspergillus niger uncharacterized protein XP_001390011.1 211024 R 5061 CDS An03g01100 84590617 complement(join(212840..212961,213051..213186,213360..213564,213976..214086,214435..214524,214658..214791)) VI 1 NT_166520.1 hypothetical protein 214791 84590617 An03g01100 Aspergillus niger hypothetical protein XP_059600200.1 212840 R 5061 CDS An03g01110 4980099 join(214894..215005,215068..215079,215163..215266,215320..215355,215421..216055,216121..216151) VI 1 NT_166520.1 Domain: mitochondrial carnitine/acylcarnitine carrier protein of R. norvegicus contains a 3-fold repeated sequence about 100 amino acids in length.; Function: mitochondrial carnitine/acylcarnitine carrier protein of R. norvegicus is involved in the transport of carnitine or acylcarnitine from the cytosol to the mitochondrial matrix.; Localization: mitochondrial carnitine/acylcarnitine carrier protein of R. norvegicus is an integral membrane protein of the inner mitochondrial membrane.; Similarity: the predicted A. niger protein shows strong similarity to mitochondrial carnitine/acylcarnitine carrier protein of R. norvegicus, which belongs to the mitochondrial carrier family.; Title: strong similarity to mitochondrial carnitine/acylcarnitine carrier protein - Rattus norvegicus; localisation:mitochondrion; See PMID 9032458; uncharacterized protein 216151 4980099 An03g01110 Aspergillus niger uncharacterized protein XP_059600201.1 214894 D 5061 CDS An03g01120 4980100 complement(join(216249..216361,216425..216514,216564..216806,216865..217345,217422..217754)) VI 1 NT_166520.1 Catalytic activity: aspartate transaminase of S. cerevisiae catalyses the reaction L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.; Cofactor: aspartate transaminase requires pyridoxal-phosphate as a cofactor.; Remark: AAT2 of S. cerevisiae is also known as ASP5 and has a systematic name of YLR027C.; Remark: in eukaryotes there are two isozymes: a cytoplasmic one and a mitochondrial one.; Similarity: the predicted A. niger protein belongs to class-I of pyridoxal-phosphate-dependent aminotransferases.; Title: strong similarity to cytosolic aspartate transaminase Aat2 - Saccharomyces cerevisiae; cytoplasm; uncharacterized protein 217754 4980100 An03g01120 Aspergillus niger uncharacterized protein XP_001390014.1 216249 R 5061 CDS An03g01130 4980101 complement(218522..219346) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein encoded by An07g06330 - Aspergillus niger; uncharacterized protein 219346 4980101 An03g01130 Aspergillus niger uncharacterized protein XP_001390015.1 218522 R 5061 CDS An03g01140 4980102 join(219953..220333,220389..220728,220791..221443) VI 1 NT_166520.1 Catalytic activity: A. phoenices oxalate decarboxylase (APOXD) catalyses the reaction oxalate = formate + CO2.; Remark: a vector containing the APOXD nucleic acid can be used to transform host cells for the recombinant production of the enzyme. the APOXD can be used for the degradation of oxalic acid in providing protection against oxalic acid toxicity. it is useful in combating and providing protection against plant pathogens that utilise oxalate to gain access to plant tissue or otherwise in the course of the pathogenesis of the disease. the APOXD gene is also useful as a selectable marker of transformed cells,for diagnostic assay of oxalate, and for production of the enzyme in plants. the product can also be used in diagnostic assays to quantify oxalate, e. g. in the diagnosis and treatment of patients with urinary tract disorders or hyperoxaluric syndromes.; Similarity: the predicted A. niger protein shows nearly identity to the protein sequence of patent WO9842827-A2 (AAW79948), which covers the A. phoenices oxalate decarboxylase (APOXD).; Title: strong similarity to oxalate decarboxylase (APOXD) from patent WO9842827-A2 - Aspergillus phoenicis; extracellular/secretion proteins; uncharacterized protein 221443 4980102 An03g01140 Aspergillus niger uncharacterized protein XP_001390016.1 219953 D 5061 CDS An03g01150 84590618 complement(join(221452..221502,221705..221767,221859..221890,221940..222035,222205..222342,222575..222614)) VI 1 NT_166520.1 hypothetical protein 222614 84590618 An03g01150 Aspergillus niger hypothetical protein XP_059600202.1 221452 R 5061 CDS An03g01160 4980104 222796..224061 VI 1 NT_166520.1 Remark: the present sequence is human epidermal protein-5 (HEPI) expressed in epidermal keratinocytes,dermal fibroblasts, and bronchial epithelium. this protein is derived from OVARNOT09 cDNA library. HEPI-5 shares 92% identity with mouse Ray protein expressed in skin. recombinant vectors comprising HEPI cDNA are introduced into host cells for protein expression. the HEPI proteins are useful for the treatment of epithelial disorders,including dyshidrotic eczema and scabies, cell proliferative disorders including actinic keratosis and arteriosclerosis, and autoimmune/inflammatory disorders like acquired immune deficiency syndrome (AIDS) and Addison's disease. pharmaceutical compositions comprising HEPI proteins are useful for treating disorders associated with altered HEPI expression.; Similarity: the predicted A. niger protein shows strong similarity to the protein sequence of patent WO200006727-A2 (AAY44988), which covers the human epidermal protein-5.; Title: strong similarity to epidermal protein-5 HEPI - Homo sapiens; uncharacterized protein 224061 4980104 An03g01160 Aspergillus niger uncharacterized protein XP_001390018.1 222796 D 5061 CDS An03g01170 4980105 join(224709..224945,225017..225289) VI 1 NT_166520.1 hypothetical protein 225289 4980105 An03g01170 Aspergillus niger hypothetical protein XP_059600203.1 224709 D 5061 CDS An03g01180 4980106 complement(join(226297..226517,226654..227158)) VI 1 NT_166520.1 Remark: ORF5 is a protein located in a gene cluster flanking the NPKS (nonaketide polyketide synthase) gene,which is known to be required for lovastatin production. this portion of the gene cluster is referred to as the 'D4B segment'. increasing lovastatin, or monacolin J,production in a lovastatin-producing organism, comprises transforming the organism with a D4B segment, and expressing it (claimed). lovastatin will also be produced in non-lovastatin producing organisms (e. g. A. nidulans) by transformation with the D4B segment and the entire LovF gene. the methods are used to increase biosynthetic production of lovastatin (with an at least 5-fold increase) which is an anti-hypercholesterolaemic agent, and also has some anti-fungal activity. lovastatin inhibits the conversion of hydroxymethylglutarylcoenzyme A (HMG-CoA) into mevalonate by HMG-CoA reductase. the methods can also be used to increase production of monacolin J (claimed),which has anti-fungal activity.; Similarity: the predicted A. niger protein shows strong similarity to the protein sequence ORF5 of patent WO200006727-A2 (AAY44988); Title: strong similarity to ORF 5 protein from patent WO200037629-A2 - Aspergillus terreus; uncharacterized protein 227158 4980106 An03g01180 Aspergillus niger uncharacterized protein XP_001390020.1 226297 R 5061 CDS An03g01190 4980107 227704..228615 VI 1 NT_166520.1 Title: strong similarity to hypothetical UDP-galactose 4-epimerase - Mesorhizobium loti; uncharacterized protein 228615 4980107 An03g01190 Aspergillus niger uncharacterized protein XP_001390021.1 227704 D 5061 CDS An03g01200 4980108 join(229377..229423,229617..229667,229725..230466,230526..231298,231357..231621) VI 1 NT_166520.1 Title: similarity to hypothetical transcription regulator SPAC11D3.07c - Schizosaccharomyces pombe; uncharacterized protein 231621 4980108 An03g01200 Aspergillus niger uncharacterized protein XP_059600204.1 229377 D 5061 CDS An03g01210 84590619 join(231745..231761,231850..231933,232028..232228,232278..232513,232641..232771,232864..232947) VI 1 NT_166520.1 hypothetical protein 232947 84590619 An03g01210 Aspergillus niger hypothetical protein XP_059600205.1 231745 D 5061 CDS An03g01220 84590620 join(233018..233404,233522..233584) VI 1 NT_166520.1 Remark: the protein sequence of patent GB2261878-A (AC# AAR35759) covers the apyrase enzyme (ATP diphosphohydrolase) of S. flexneri. the apyrase enzyme is associated with the virulence of all species of Shigella (e. g. S. flexneri, S. dysenteriae, S. sonnei, S. boydii) and related entero-invasive E. coli (EIEC) strains. the apyrase nucleotide sequence can be used in the detection of a virulence determinant in pathogenic bacteria.; Title: weak similarity to apyrase from patent GB2261878-A - Shigella flexneri; uncharacterized protein 233584 84590620 An03g01220 Aspergillus niger uncharacterized protein XP_059600206.1 233018 D 5061 CDS An03g01230 4980111 complement(join(233903..234288,234367..234583,234644..235669,235707..235841)) VI 1 NT_166520.1 Function: biochemical analysis has shown that Csc25 of C. albicans activates the Ras/adenylyl cyclase pathway in S. cerevisiae at a rate two to three times faster than Cdc25 of S. cerevisiae, under the same conditions.; Similarity: similarity is restricted to carboxyterminus as usual for the proteins of the CDC25 family.; Similarity: the size of proteins of this family ranges from 309 residues (LTE1) to 1596 residues (sos).; Title: strong similarity to cell division cycle protein CDC25 - Candida albicans; See PMID 8477693; uncharacterized protein 235841 4980111 An03g01230 Aspergillus niger uncharacterized protein XP_059600207.1 233903 R 5061 CDS An03g01240 4980112 complement(join(236315..237249,237297..237320,237375..237910,237971..238245)) VI 1 NT_166520.1 Function: the transporter for enterobactin (Enb1p) of S. cerevisiae specifically facilitates the uptake of catecholate-type siderophores.; Similarity: S. cerevisiae transporter for enterobactin (Enb1p), also known as YOL158c, and the predicted A. niger protein show strong similarity to the major facilitator superfamily.; Title: strong similarity to hypothetical siderophore-iron transporter for enterobactin Enb1 -Saccharomyces cerevisiae; plasma membrane; See PMID 10831226; uncharacterized protein 238245 4980112 An03g01240 Aspergillus niger uncharacterized protein XP_059600208.1 236315 R 5061 CDS An03g01250 84590621 complement(join(238363..238648,238975..239189)) VI 1 NT_166520.1 Title: questionable ORF; uncharacterized protein 239189 84590621 An03g01250 Aspergillus niger uncharacterized protein XP_059600209.1 238363 R 5061 CDS An03g01260 84590622 complement(join(240032..240196,240266..240337)) VI 1 NT_166520.1 hypothetical protein 240337 84590622 An03g01260 Aspergillus niger hypothetical protein XP_059600210.1 240032 R 5061 CDS An03g01270 4980115 join(241457..241546,241613..242052,242110..242281) VI 1 NT_166520.1 Title: weak similarity to hypothetical aminopeptidase SC8E4A.05 - Streptomyces coelicolor; uncharacterized protein 242281 4980115 An03g01270 Aspergillus niger uncharacterized protein XP_001390029.3 241457 D 5061 CDS An03g01280 4980116 join(242812..243256,243310..244658,244734..244817) VI 1 NT_166520.1 Catalytic activity: glutaminyl-tRNA synthetase of S. cerevisiae catalyses the reaction ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).; Pathway: glutaminyl-tRNA synthetase activates L-glutamine for protein biosynthesis.; Remark: the amino-terminal extension of glutaminyl-tRNA synthetase of S. cerevisiae is dispensable for aminoacylation activity.; Remark: the patent match is against the translated human ORFX ORF2056 polynucleotide sequence (SEQ ID NO:4111) of patent WO200058473-A2 (AC# AAC76501).; Remark: the predicted A. niger protein may not be complete at the N-terminus, as its length is inbetween pro-and eucaryotic glutaminyl-tRNA synthetases.; Similarity: glutaminyl-tRNA synthetases of eucaryotes and procaryotes are highly conserved but differ in length due to longer eucaryotic N-terminal sequences.; Title: strong similarity to glutamine--tRNA ligase -Saccharomyces cerevisiae; See PMID 3301842; See PMID 8449914; See PMID 3301841; uncharacterized protein 244817 4980116 An03g01280 Aspergillus niger uncharacterized protein XP_001390030.1 242812 D 5061 CDS An03g01290 4980117 join(245471..246140,246197..246565,246630..247075,247163..247492) VI 1 NT_166520.1 Similarity: the predicted A. niger protein shows strong similarity to several conserved hypothetical procaryotic proteins.; Title: strong similarity to hypothetical large secreted protein - Streptomyces coelicolor; uncharacterized protein 247492 4980117 An03g01290 Aspergillus niger uncharacterized protein XP_001390031.1 245471 D 5061 CDS An03g01300 4980118 join(248120..248154,248535..248692,248810..248970,249024..249128,249185..249582,249669..249733,249806..250290) VI 1 NT_166520.1 Function: the pathogenicity protein PTH11 functions at the cell cortex as an upstream effector of appressorium differentiation in response to surface cues.; Localization: a PTH11-green fluorescent protein fusion was localized to the cell membrane and vacuoles.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; uncharacterized protein 250290 4980118 An03g01300 Aspergillus niger uncharacterized protein XP_001390032.3 248120 D 5061 CDS An03g01310 4980119 complement(join(251270..252848,252918..253053,253147..253171)) VI 1 NT_166520.1 Catalytic activity: CTP synthetase of S. cerevisiae catalyses the reaction ATP + UTP + NH(3) = ADP + phosphate + CTP.; Pathway: CTP synthetase catalyses the last reaction in the pyrimidine biosynthesis pathway.; Remark: in the presence of saturating concentrations of ATP and UTP, the URA7-encoded CTP synthetase exists as a tetramer.; Remark: phosphorylation of URA7-encoded CTP synthetase with protein kinase A stimulates its activity to 190%.; Remark: the CTP synthetases encoded by URA7 and URA8 of S. cerevisiae differ significantly with respect to several biochemical properties including turnover number,pH optimum, substrate dependences, and sensitivity to inhibition by CTP.; Similarity: the predicted A. niger protein is similar to both CTP synthetases (URA7 and URA8) of S. cerevisiae.; Title: strong similarity to CTP synthase Ura7 -Saccharomyces cerevisiae; cytoplasm; See PMID 7559626; See PMID 8121398; See PMID 8910520; See PMID 9632643; See PMID 1753946; uncharacterized protein 253171 4980119 An03g01310 Aspergillus niger uncharacterized protein XP_001390033.1 251270 R 5061 CDS An03g01320 4980120 254415..255185 VI 1 NT_166520.1 Title: strong similarity to hypothetical protein mlr2056 - Mesorhizobium loti; uncharacterized protein 255185 4980120 An03g01320 Aspergillus niger uncharacterized protein XP_001390034.1 254415 D 5061 CDS An03g01330 84590623 join(255393..255499,255616..255774,255985..256050,256180..256337,256532..256593) VI 1 NT_166520.1 hypothetical protein 256593 84590623 An03g01330 Aspergillus niger hypothetical protein XP_059600211.1 255393 D 5061 CDS An03g01340 84590624 complement(join(256927..257125,257283..257452,257655..257666)) VI 1 NT_166520.1 hypothetical protein 257666 84590624 An03g01340 Aspergillus niger hypothetical protein XP_059600212.1 256927 R 5061 CDS An03g01350 4980124 join(257722..257896,258034..258116,258170..258346,258402..258471,258528..258778,258831..259097) VI 1 NT_166520.1 Catalytic activity: alcohol dehydrogenase I (alcA) of A. nidulans catalyses the reaction alcohol + NAD(+) = aldehyde or ketone + NADH.; Cofactor: alcohol dehydrogenase I requires zinc 2+ for its activity.; Pathway: alcohol dehydrogenase I is involved in glycolysis / gluconeogenesis; fatty acid metabolism; bile acid biosynthesis; tyrosine metabolism; glycerolipid metabolism.; Regulation: alcohol dehydrogenase (ADH) I is induced by the transactivator alcR.; Remark: alcR itself is inducible by ethanol or acetaldehyde. alcR is subject to carbon catabolite repression and its expression is controlled by the negatively acting creA wide specificity gene. the repression of alcR is sufficient to explain the carbon catabolite repression of ADH I.; Remark: the patent match is against the A. niger adhA gene of patent WO8704464-A (AC# AAP70497).; Similarity: alcohol dehydrogenase I (alcA) of A. nidulans belongs to the zinc-containing alcohol dehydrogenase family.; Title: strong similarity to alcohol dehydrogenase alcA - Aspergillus nidulans; cytoplasm; See PMID 3158573; See PMID 3297923; uncharacterized protein 259097 4980124 An03g01350 Aspergillus niger uncharacterized protein XP_059600213.1 257722 D 5061 CDS An03g01360 84590625 join(259113..259337,259388..259721,259775..260112,260166..260492) VI 1 NT_166520.1 Catalytic activity: low specificity threonine aldolase of S. cerevisiae catalyses the reaction L-allo-threonine or L-threonine = glycine + acetaldehyde.; Cofactor: low specificity threonine aldolase of S. cerevisiae needs pyridoxal phosphate as a cofactor.; Complex: GLY1 of S. cerevisiae exists as a homotetramer.; Pathway: threonine aldolase catalyses the last step in the glycine biosynthesis pathway.; Remark: GLY1 of S. cerevisiae has the systematic name of YEL046C.; Similarity: low specificity threonine aldolase of S. cerevisiae and the predicted A. niger protein belong to the threonine aldolase family.; Title: strong similarity to threonine aldolase Gly1 - Saccharomyces cerevisiae; See PMID 8132653; See PMID 9151955; See PMID 9163906; uncharacterized protein 260492 84590625 An03g01360 Aspergillus niger uncharacterized protein XP_059600214.1 259113 D 5061 CDS An03g01370 4980125 complement(260675..261559) VI 1 NT_166520.1 Title: strong similarity to hypothetical oxidoreductase of gene CC3685 - Caulobacter crescentus; uncharacterized protein 261559 4980125 An03g01370 Aspergillus niger uncharacterized protein XP_001390039.1 260675 R 5061 CDS An03g01380 84590626 join(262220..262231,262273..262617) VI 1 NT_166520.1 hypothetical protein 262617 84590626 An03g01380 Aspergillus niger hypothetical protein XP_059600215.1 262220 D 5061 CDS An03g01390 4980127 263005..264222 VI 1 NT_166520.1 Remark: the patent match is against the protein sequence of 6-hydroxynicotinic acid mono-oxygenase covered by patent JP09121864-A (AC# AAW10018).; Remark: the patented 6-hydroxynicotinic acid mono-oxygenase is useful for the industrial production of 2, 5-dihydroxypyridine.; Remark: the predicted A. niger protein shows strong similarity to several probable oxidoreductases of different procaryotic organisms.; Title: similarity to 6-hydroxynicotinic acid mono-oxygenase from patent JP09121864-A - Pseudomonas fluorescens; uncharacterized protein 264222 4980127 An03g01390 Aspergillus niger uncharacterized protein XP_001390041.1 263005 D 5061 CDS An03g01400 84590627 complement(join(265262..265693,265972..266067)) VI 1 NT_166520.1 Similarity: the ORF shows strong similarity to another A. niger protein. The similarity between the two proteins, however, is restricted to a stretch of about 100 amino acids.; Title: strong similarity to hypothetical protein encoded by An08g12070 - Aspergillus niger; uncharacterized protein 266067 84590627 An03g01400 Aspergillus niger uncharacterized protein XP_059600216.1 265262 R 5061 CDS An03g01410 4980130 join(266475..267418,267474..268218) VI 1 NT_166520.1 Similarity: the ORF shows similarity to another A. niger protein. The similarity between the two proteins,however, is restricted to a stretch of about 100 amino acids.; Title: similarity to hypothetical protein encoded by An01g02950 - Aspergillus niger; uncharacterized protein 268218 4980130 An03g01410 Aspergillus niger uncharacterized protein XP_059600217.1 266475 D 5061 CDS An03g01420 84590628 join(269072..271097,271212..271273) VI 1 NT_166520.1 Title: weak similarity to polypeptide SEQ ID NO:1833 from patent WO200171042-A2 - Drosophila melanogaster; uncharacterized protein 271273 84590628 An03g01420 Aspergillus niger uncharacterized protein XP_059600218.1 269072 D 5061 CDS An03g01430 4980131 complement(join(273429..273860,273923..274131,274205..274344,274395..274621,274672..274812)) VI 1 NT_166520.1 Function: M. grisea Pth11 is a pathogenicity gene.; Function: M. grisea Pth11p likely is involved in host surface recognition.; Function: M. grisea pth11 mutants of strain 4091-5-8 are nonpathogenic due to a defect in appressorium differentiation.; Localization: in M. grisea a Pth11-green fluorescent protein fusion localised to the cell membrane and vacuoles.; Similarity: similarity of the predicted A. niger protein and M. grisea Pth11 is limited to the N-terminal half of the protein sequences.; Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529; uncharacterized protein 274812 4980131 An03g01430 Aspergillus niger uncharacterized protein XP_001390045.1 273429 R 5061 CDS An03g01440 84590629 join(275608..275726,275820..275885,275984..276050,276141..276269) VI 1 NT_166520.1 hypothetical protein 276269 84590629 An03g01440 Aspergillus niger hypothetical protein XP_059600219.1 275608 D 5061 CDS An03g01450 4980133 complement(join(276548..276780,276840..277127,277188..277564,277615..277761,277814..278117,278180..278235,278292..278482)) VI 1 NT_166520.1 Remark: the patented DNA sequence encodes a Corynebacterium glutamicum membrane construction and membrane transport (MCT) protein. MCT nucleic acids and proteins are useful in the identification of microorganisms which can be used to produce fine chemicals, for modulating fine chemical production in C. glutamicum or related bacteria (e. g. Brevibacterium lactofermentum), the typing or identification of C. glutamicum or related bacteria, as reference points for mapping C. glutamicum genome, and as markers for transformation.; Similarity: the predicted A. niger protein and the translated DNA sequence (ID NO:513) of patent WO200100805-A2 (AC# AAF67999) belong to the major facilitator superfamily.; Similarity: the predicted A. niger protein is strongly similar to the putative membrane transporter encoded by SPAPB1E7. 08 of S. pombe.; Title: similarity to MCT protein from patent WO200100805-A2 - Corynebacterium glutamicum; uncharacterized protein 278482 4980133 An03g01450 Aspergillus niger uncharacterized protein XP_059600220.1 276548 R 5061 CDS An03g01460 4980134 complement(join(278943..279290,279354..279832,279891..280113)) VI 1 NT_166520.1 Catalytic activity: gibberellin (GA) 7-oxidase oxidizes GA12-aldehyde to GA12 and GA14-aldehyde to GA14. they further metabolise GA12 to four products, two of which are monohydroxylated GA12.; Pathway: gibberellin 7-oxidase of C. maxima catalyses the last step in gibberellin biosynthesis.; Similarity: gibberellin 7-oxidase of C. maxima belongs to the superfamily of 1-aminocyclopropane-1-carboxylate oxidases.; Title: strong similarity to gibberellin 7-oxidase -Cucurbita maxima; See PMID 9177256; uncharacterized protein 280113 4980134 An03g01460 Aspergillus niger uncharacterized protein XP_001390048.1 278943 R 5061 CDS An03g01470 4980135 join(280561..280664,280716..280765,280858..281055,281100..281184,281229..281685,281735..282126,282173..282368) VI 1 NT_166520.1 Remark: the genes for phthalate degradation are arranged in at least three transcriptional units in B. cepacia. the gene for phthalate dioxygenase reductase (ophA1) is present by itself, while the genes for an inactive transporter (ophD) and 4,5-dihydroxyphthalate decarboxylase (ophC) are linked and the genes for phthalate dioxygenase oxygenase (ophA2) and cis-phthalate dihydrodiol dehydrogenase (ophB) are linked.; Remark: uptake inhibition experiments show that 4-hydroxyphthalate, 4-chlorophthalate, 4-methylphthalate,and cinchomeronate compete for the phthalate permease of B. cepacia.; Similarity: the phthalate transporter (ophD) of B. cepacia belongs to the major facilitator superfamily.; Title: strong similarity to phthalate permease ophD - Burkholderia cepacia; plasma membrane; See PMID 9851995; See PMID 10498738; uncharacterized protein 282368 4980135 An03g01470 Aspergillus niger uncharacterized protein XP_059600221.1 280561 D 5061 CDS An03g01480 4980136 join(282679..283297,283333..284574,284667..284959) VI 1 NT_166520.1 Similarity: the predicted A. niger protein shows similarity to several hypothetical fungal proteins with an N-terminal C2H2 zinc finger domain and a conserved C-terminus.; Title: strong similarity to hypothetical C2H2 zinc finger protein - Schizosaccharomyces pombe; uncharacterized protein 284959 4980136 An03g01480 Aspergillus niger uncharacterized protein XP_059600222.1 282679 D 5061 CDS An03g01490 4980137 complement(285317..286171) VI 1 NT_166520.1 Remark: the patent match is against the translated DNA sequence 791 of patent WO0100843-A/791 (AC# AX064509).; Remark: the patent simply states that it covers C. glutamicum genes encoding metabolic pathway proteins.; Title: strong similarity to protein sequence 791 from patent WO0100843-A - Corynebacterium glutamicum; uncharacterized protein 286171 4980137 An03g01490 Aspergillus niger uncharacterized protein XP_001390051.1 285317 R 5061 CDS An03g01500 84590630 complement(join(286493..287287,287318..287497)) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein encoded by An11g08910 - Aspergillus niger; uncharacterized protein 287497 84590630 An03g01500 Aspergillus niger uncharacterized protein XP_059600223.1 286493 R 5061 CDS An03g01510 84590631 join(288021..288044,288145..288513) VI 1 NT_166520.1 hypothetical protein 288513 84590631 An03g01510 Aspergillus niger hypothetical protein XP_059600224.1 288021 D 5061 CDS An03g01520 4980140 complement(join(288984..289919,289975..290193)) VI 1 NT_166520.1 Catalytic activity: 12-oxophytodienoate reductase (opr) of L. esculentum catalyses the reaction 8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-enyl}cyclopentyl]octanoate + NADP(+) = (15Z)-12-oxophyto-10,15-dienoate + NADPH.; Cofactor: 12-oxophytodienoate reductase (opr) of L. esculentum is a flavin (FMN)-protein.; Pathway: L. esculentum 12-oxophytodienoate reductase is an enzyme of the octadecanoid signaling pathway.; Remark: photoreduction of the LeOPR-bound FMN resulted in the formation of a red, anionic semiquinone prior to the formation of the fully reduced flavin dihydroquinone. spectroscopic characterization of LeOPR revealed the formation of charge transfer complexes upon titration with para-substituted phenolic compounds, a distinctive feature of the enzymes of the OYE (Old Yellow Enzyme) family.; Similarity: 12-oxophytodienoate reductase (opr) of L. esculentum (LeOPR) and the predicted protein of A niger show strong similarity to NADH:flavin oxidoreductases.; Title: strong similarity to 12-oxophytodienoate reductase opr - Lycopersicon esculentum; See PMID 10574986; uncharacterized protein 290193 4980140 An03g01520 Aspergillus niger uncharacterized protein XP_001390054.1 288984 R 5061 CDS An03g01530 4980141 join(290799..291075,291116..291215,291256..291442,291518..293388,293448..294627,294683..295216) VI 1 NT_166520.1 Catalytic activity: xanthine dehydrogenase (hxA) of A. nidulans catalyses the reaction xanthine + NAD(+) + H2O = urate + NADH.; Cofactor: xanthine dehydrogenase (hxA) of A. nidulans requires molybdenum as a cofactor.; Induction: the transcription of the hxA gene of A. nidulans is induced by the uric acid analogue 2-thiouric acid and repressed by ammonium. induction necessitates the product of the uaY regulatory gene.; Pathway: xanthine dehydrogenase (hxA) of A. nidulans is involved in the catabolism of adenine, urate and hypoxanthine.; Remark: the 5'-EST an_3264 of A. niger is highly similar to the nucleotide sequence of the ORF. this EST most likely encodes a C-terminal fragment of the A. niger xanthine dehydrogenase.; Title: strong similarity to xanthine dehydrogenase hxA - Aspergillus nidulans; See PMID 7876088; uncharacterized protein 295216 4980141 An03g01530 Aspergillus niger uncharacterized protein XP_059600225.1 290799 D 5061 CDS An03g01540 4980142 complement(join(295558..295564,295616..295671,295718..296045,296100..296246,296291..296429,296478..297123,297176..297235)) VI 1 NT_166520.1 Catalytic activity: salicylate 1-hydroxylases catalyse the reaction salicylate + NAD(H) + O(2) = catechol + NAD(+) + H(2)O + CO(2).; Cofactor: salicylate 1-hydroxylase requires the cofactor FAD.; Induction: nahG and nahW genes of P. stutzeri AN10 are induced and expressed upon incubation with salicylate.; Pathway: NahG and NahW are involved in naphthalene and salicylate metabolism.; Remark: both enzymes exhibit broad substrate specificities and metabolize salicylate, methylsalicylates,and chlorosalicylates.; Similarity: the predicted A. niger protein shows homology to two independent salicylate 1-hydroxylases (NahG and NahW) of P. stutzeri.; Title: strong similarity to salicylate hydroxylase nahW - Pseudomonas stutzeri; See PMID 10197990; uncharacterized protein 297235 4980142 An03g01540 Aspergillus niger uncharacterized protein XP_001390056.3 295558 R 5061 CDS An03g01550 84590632 join(297512..297520,297572..297747,297808..>298030) VI 1 NT_166520.1 Catalytic activity: gluconate:NADP 5-oxidoreductase (GNO) of G. oxydans catalyses the reaction D-gluconate + NAD(P)(+) = 5-dehydro-D-gluconate + NAD(P)H.; Remark: GNO is involved in the nonphosphorylative,ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate.; Similarity: GNO of G. oxydans shows homology to members of the short-chain alcohol dehydrogenase family.; Specificity: GNO of G. oxydans is almost inactive with NAD as a cofactor and is very specific for the substrates gluconate and 5-ketogluconate.; Title: similarity to gluconate:NADP 5-oxidoreductase GNO - Gluconobacter oxydans [truncated ORF]; cytoplasm; See PMID 7751271; See PMID 7981120; uncharacterized protein 298030 84590632 An03g01550 Aspergillus niger uncharacterized protein XP_059600226.1 297512 D 5061 CDS An03g01560 4980144 join(298413..298513,298576..298750,298819..299191,299261..299488,299544..299626,299687..300568) VI 1 NT_166520.1 Catalytic activity: phenol + NADPH + O(2) = catechol + NADP(+) + H(2)O (acts also on monohydroxy-, monohalo-,monoamino- and monomethylphenols).; Cofactor: phenol 2-monooxygenase of T. cutaneum is a FAD flavoprotein.; Complex: phenol 2-monooxygenase of T. cutaneum is a homodimer.; Pathway: phenol 2-monooxygenase of T. cutaneum catalyzes the first step of phenol biodegradation.; Regulation: phenol 2-monooxygenase of T. cutaneum is inhibited by excess phenol.; Title: strong similarity to phenol 2-monooxygenase -Trichosporon cutaneum; See PMID 1429434; uncharacterized protein 300568 4980144 An03g01560 Aspergillus niger uncharacterized protein XP_059600227.1 298413 D 5061 CDS An03g01570 4980145 complement(join(301070..301848,301904..302605,302655..304026)) VI 1 NT_166520.1 Function: the expression of spoVK in mother cells from B. subtilis is necessary for the completion of spore development.; Phenotype: mutations in spoVK of B. subtilis block the sporulation at a late stage.; Remark: manual closest BLASTP homologue: PIR:S16301.; Remark: spoVK of B. subtilis is also called spoVJ and belongs to the cbxx/cfxq superfamily, which members harbour conserved sequence motifs.; Title: similarity to stage V sporulation protein spoVK - Bacillus subtilis; See PMID 1732196; See PMID 1787791; See PMID 2514336; See PMID 6405008; uncharacterized protein 304026 4980145 An03g01570 Aspergillus niger uncharacterized protein XP_001390059.1 301070 R 5061 CDS An03g01580 84590633 complement(join(304392..304530,304574..304918,305066..305097,305219..305351,305471..305576,305656..305785)) VI 1 NT_166520.1 hypothetical protein 305785 84590633 An03g01580 Aspergillus niger hypothetical protein XP_059600228.1 304392 R 5061 CDS An03g01590 4980147 complement(join(306278..306844,306931..307394,307467..307647,307697..308134)) VI 1 NT_166520.1 Function: GAP1 of S. cerevisiae transports all naturally-occurring L-amino acids, GABA, ornithine,citrulline, some D-amino acids, and some toxic analogs.; Similarity: GAP1 of S. cerevisiae belongs to the major facilitator superfamily.; Title: strong similarity to general amino acid permease Gap1 - Saccharomyces cerevisiae; plasma membrane; See PMID 8720066; See PMID 8893857; See PMID 9171427; See PMID 9199164; See PMID 2194797; uncharacterized protein 308134 4980147 An03g01590 Aspergillus niger uncharacterized protein XP_001390061.3 306278 R 5061 CDS An03g01600 84590634 complement(join(309248..309475,309527..309597,309672..309831,309900..309959)) VI 1 NT_166520.1 hypothetical protein 309959 84590634 An03g01600 Aspergillus niger hypothetical protein XP_059600229.1 309248 R 5061 CDS An03g01610 84590635 complement(join(310579..310815,310855..310985,311391..311493)) VI 1 NT_166520.1 hypothetical protein 311493 84590635 An03g01610 Aspergillus niger hypothetical protein XP_059600230.1 310579 R 5061 CDS An03g01620 4980150 join(312836..312860,312915..313042,313117..313303,313360..313886,313946..314236,314304..314687) VI 1 NT_166520.1 Function: high affinity glucose transporter.; Remark: expression of HGT1 from Kluyveromyces lactis is constitutive (in contrast to RAG1, the major gene for low-affinity glucose uptake in K. lactis) and is controlled by several genes also known to affect expression of RAG1.; Similarity: belongs to the sugar transporter family.; Title: strong similarity to high affinity glucose transporter HGT1 - Kluyveromyces lactis; plasma membrane; See PMID 8830679; uncharacterized protein 314687 4980150 An03g01620 Aspergillus niger uncharacterized protein XP_001390064.1 312836 D 5061 CDS An03g01630 4980151 join(315807..316011,316070..316404) VI 1 NT_166520.1 hypothetical protein 316404 4980151 An03g01630 Aspergillus niger hypothetical protein XP_001390065.3 315807 D 5061 CDS An03g01640 4980152 join(317579..317783,317816..317895) VI 1 NT_166520.1 Similarity: the ORF shows weak similarity to another A. niger protein. The similarity between the two proteins,however, is restricted to a stretch of about 40 amino acids.; Title: weak similarity to hypothetical protein encoded by An14g06170 - Aspergillus niger; uncharacterized protein 317895 4980152 An03g01640 Aspergillus niger uncharacterized protein XP_059600231.1 317579 D 5061 CDS An03g01650 4980153 complement(join(318071..318286,318340..319335)) VI 1 NT_166520.1 Function: The mae1 gene encodes a permease involved in the uptake of L-malate, succinate and malonic acid.; Title: similarity to C4-dicarboxylate transport protein mae1p - Schizosaccharomyces pombe; plasma membrane; See PMID 8750236; uncharacterized protein 319335 4980153 An03g01650 Aspergillus niger uncharacterized protein XP_001390067.1 318071 R 5061 CDS An03g01660 4980154 join(320630..320888,320954..322095,322167..322288,322599..322722) VI 1 NT_166520.1 Function: APE3 of S. cerevisiae is a metallo (Zn2+) aminopeptidase activated by Co2+, and represents the major vacuolar aminopeptidase with preference for basic amino acids and proline.; Remark: APE3 of S. cerevisiae is also called APY1 or YBR286W.; Title: strong similarity to vacuolar aminopeptidase Y Ape3 - Saccharomyces cerevisiae; vacuole; See PMID 8175800; See PMID 8674980; See PMID 10551827; See PMID 10590462; See PMID 8175799; uncharacterized protein 322722 4980154 An03g01660 Aspergillus niger uncharacterized protein XP_001390068.3 320630 D 5061 CDS An03g01670 4980155 join(323252..323499,323573..323610,323665..323724,323924..324001,324058..324214,324299..324323) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein encoded by An10g00970 - Aspergillus niger; uncharacterized protein 324323 4980155 An03g01670 Aspergillus niger uncharacterized protein XP_059600232.1 323252 D 5061 CDS An03g01680 4980156 complement(join(324449..324636,324717..325242)) VI 1 NT_166520.1 Similarity: 80% of the predicted protein is constituted by repetitive, low-complexity regions; these explain some BLASTP hits that cannot be considered significant.; hypothetical protein 325242 4980156 An03g01680 Aspergillus niger hypothetical protein XP_001390070.1 324449 R 5061 CDS An03g01690 4980157 complement(327058..328560) VI 1 NT_166520.1 Catalytic activity: dat of A. baumannii catalyzes the following reversible reaction: L-2,4-diaminobutyric acid + 2-ketoglutaric acid<-->L-glutamic acid + L-aspartic beta-semialdehyde.; Function: dat of A. baumannii participates in the synthesis of 1,3-diaminopropane, the only diamine found in this genus; however, the biological role, if one exists, of 1,3-diaminopropane synthesis is unknown.; Similarity: the predicted protein shows similarity also to other decarboxylases with different specificity.; Title: strong similarity to L-2,4-diaminobutyrate decarboxylase dat - Acinetobacter baumannii; See PMID 8772175; See PMID 9260954; uncharacterized protein 328560 4980157 An03g01690 Aspergillus niger uncharacterized protein XP_001390071.1 327058 R 5061 CDS An03g01700 4980158 complement(329808..331403) VI 1 NT_166520.1 Function: fumonisin esterases from E. spinifera can degrade fumonisin.; Remark: fumonisins, a class of mycotoxins, have cancer-promoting activity.; Title: strong similarity to fumonisin esterase BAA-ESP1 from patent WO9902703-A1 - Exophiala spinifera; See PMID 10441035; uncharacterized protein 331403 4980158 An03g01700 Aspergillus niger uncharacterized protein XP_001390072.1 329808 R 5061 CDS An03g01710 4980159 complement(join(332501..332830,332909..333002,333048..333178,333283..333451,333513..333571)) VI 1 NT_166520.1 Remark: the matching coding sequence was isolated by RT-PCR on all of the mRNA from A. thaliana.; Remark: there are no further informations about the patent available.; Title: strong similarity to protein fragment SEQ ID NO:22769 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 333571 4980159 An03g01710 Aspergillus niger uncharacterized protein XP_059600233.1 332501 R 5061 CDS An03g01720 84590636 complement(join(334558..334819,334896..334940,334985..335058)) VI 1 NT_166520.1 hypothetical protein 335058 84590636 An03g01720 Aspergillus niger hypothetical protein XP_059600234.1 334558 R 5061 CDS An03g01730 84590637 complement(join(335118..335288,335404..335596,335718..335798,335989..336148,336222..336276)) VI 1 NT_166520.1 Title: weak similarity to galactitol utilization operon repressor encoded by ECs2893 - Escherichia coli; uncharacterized protein 336276 84590637 An03g01730 Aspergillus niger uncharacterized protein XP_059600235.1 335118 R 5061 CDS An03g01740 4980162 336350..337600 VI 1 NT_166520.1 Title: similarity to hypothetical protein CAD70538.1 - Neurospora crassa; uncharacterized protein 337600 4980162 An03g01740 Aspergillus niger uncharacterized protein XP_001390076.1 336350 D 5061 CDS An03g01750 4980163 join(338243..338661,338718..339813) VI 1 NT_166520.1 Function: Mst1 from A. muscaria is a monosaccharide transporter.; Induction: Mst1 from A. muscaria is constitutively expressed in fungal hyphae under all growth conditions.; Induction: in mycorrhizas and in hyphae from A. muscaria grown at higher monosaccharide concentrations increased the amount of AmMst1 transcript fourfold.; Title: strong similarity to monosaccharide transporter AmMst-1 - Amanita muscaria; plasma membrane; See PMID 9487692; uncharacterized protein 339813 4980163 An03g01750 Aspergillus niger uncharacterized protein XP_001390077.1 338243 D 5061 CDS An03g01760 84590638 complement(join(340490..341108,341183..341445,341667..341887,341962..342628,342831..343088,343144..343293)) VI 1 NT_166520.1 Function: ntf1 from S. pombe plays an important role in regulating the expression of the thiamine repressible gene nmt1.; Title: strong similarity to transcription factor ntf1p - Schizosaccharomyces pombe; nucleus; See PMID 8163491; uncharacterized protein 343293 84590638 An03g01760 Aspergillus niger uncharacterized protein XP_059600236.1 340490 R 5061 CDS An03g01770 4980165 complement(join(344557..344630,344666..345239)) VI 1 NT_166520.1 Similarity: the ORF also shows strong similarity to the EST an_3410 from Aspergillus niger.; Title: strong similarity to EST an_3645 -Aspergillus niger; uncharacterized protein 345239 4980165 An03g01770 Aspergillus niger uncharacterized protein XP_059600237.1 344557 R 5061 CDS An03g01780 84590639 complement(join(345585..345816,345892..345992,346085..346144,346265..346306)) VI 1 NT_166520.1 hypothetical protein 346306 84590639 An03g01780 Aspergillus niger hypothetical protein XP_059600238.1 345585 R 5061 CDS An03g01790 4980167 complement(join(<348531..349076,349149..349898,350046..350180)) VI 1 NT_166520.1 Remark: the ORF is truncated and contains no stop codon, due to the end of the contig.; Similarity: the ORF encoded protein shows similarities to transporter proteins.; Title: strong similarity to transporter protein from patent WO0100804-A - Corynebacterium glutamicum [truncated ORF]; plasma membrane; uncharacterized protein 350180 4980167 An03g01790 Aspergillus niger uncharacterized protein XP_059600239.1 348531 R 5061 CDS An03g01800 4980168 join(351419..351493,351572..351646,351747..351863) VI 1 NT_166520.1 Function: this bovine brain derived endogenous benzodiazepinoid or endozepine (EBZD) protein is a valium agonist binding to diazepam receptors.; Remark: at low dosage EBZD causes agitation and heightened awareness while at high dosage it causes sedation.; Similarity: the ORF shows similarity to acyl-coenzyme A-binding proteins, which is involved in membrane lipid transport/biogenesis by influencing acyl-CoA metabolism.; Title: strong similarity to brain polypeptide endogenous benzodiazepinoid EBZD from patent US5011777-A -Bos taurus; See PMID 1454809; See PMID 10331663; uncharacterized protein 351863 4980168 An03g01800 Aspergillus niger uncharacterized protein XP_001390082.1 351419 D 5061 CDS An03g01810 4980169 complement(join(353983..354803,354841..354870,355235..355283)) VI 1 NT_166520.1 Remark: there are no further informations about the patent available.; Title: similarity to ORF5 protein from patent WO200037629-A2 - Aspergillus terreus; uncharacterized protein 355283 4980169 An03g01810 Aspergillus niger uncharacterized protein XP_001390083.3 353983 R 5061 CDS An03g01820 4980170 join(355608..356638,356699..362072) VI 1 NT_166520.1 Phenotype: the disruption of the Nodulisporium melanin polyketide synthase pks1 gene results in a mel(-) phenotype.; Title: strong similarity to melanin polyketide synthase PKS - Nodulisporium sp.; See PMID 10628853; uncharacterized protein 362072 4980170 An03g01820 Aspergillus niger uncharacterized protein XP_059600240.1 355608 D 5061 CDS An03g01830 4980171 complement(363040..363849) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein encoded by An12g05420 - Aspergillus niger; uncharacterized protein 363849 4980171 An03g01830 Aspergillus niger uncharacterized protein XP_001390085.1 363040 R 5061 CDS An03g01850 4980173 complement(365114..365941) VI 1 NT_166520.1 Remark: the matching coding sequence was isolated by RT-PCR on all of the mRNA from A. thaliana.; Remark: there are no further informations about the patent available.; Title: similarity to protein fragment SEQ ID NO:1406 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 365941 4980173 An03g01850 Aspergillus niger uncharacterized protein XP_001390086.1 365114 R 5061 CDS An03g01860 4980174 complement(367147..367758) VI 1 NT_166520.1 Catalytic activity: N-Carbamoylsarcosine + H2O = Sarcosine + CO2 + NH3.; Cofactor: one sulfate ion per subunit.; Complex: homotetramer.; Title: similarity to N-carbamoyl-sarcosine amidohydrolase CSHase from patent EP476670-A - Arthrobacter sp.; See PMID 8913306; See PMID 1381445; uncharacterized protein 367758 4980174 An03g01860 Aspergillus niger uncharacterized protein XP_001390087.1 367147 R 5061 CDS An03g01870 84590640 join(369192..369407,369464..369598,369645..370391) VI 1 NT_166520.1 Title: similarity to hypothetical cysteine-binding protein fliY - Haloferax volcanii; uncharacterized protein 370391 84590640 An03g01870 Aspergillus niger uncharacterized protein XP_059600241.1 369192 D 5061 CDS An03g01880 4980176 370791..371348 VI 1 NT_166520.1 Function: an intermediate step in the Ubiquitylation reaction consist of a reversible thiolester binding between the C-terminal Glycin of Ubiquitin and an Cystein of the Ubiquitin conjugating enzyme.; Remark: the essentiell Cystein residue for a ubiquitin conjugating activity is conserved.; Remark: the matching coding sequence was isolated by RT-PCR on all of the mRNA from A. thaliana.; Remark: there are no further informations about the patent available.; Title: strong similarity to ubiquitin conjugating enzyme SEQ ID NO:908 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 371348 4980176 An03g01880 Aspergillus niger uncharacterized protein XP_001390089.3 370791 D 5061 CDS An03g01890 4980177 join(372080..372646,372713..373531) VI 1 NT_166520.1 Title: weak similarity to microtubule-associated protein tau - Mus musculus; uncharacterized protein 373531 4980177 An03g01890 Aspergillus niger uncharacterized protein XP_059600242.1 372080 D 5061 CDS An03g01900 4980178 join(374311..374523,374573..374682,374796..374937,374995..375365,375415..375748,375810..375836,376141..376293,376354..376591,376803..376809,377284..377374,377422..377445) VI 1 NT_166520.1 hypothetical protein 377445 4980178 An03g01900 Aspergillus niger hypothetical protein XP_059600243.1 374311 D 5061 CDS An03g01910 4980179 complement(377982..379487) VI 1 NT_166520.1 Catalytic activity: ATP + N-Acetyl-L-glutamate = ADP + N-Acetyl-L-glutamate 5-phosphate.; Complex: Acetylglutamate kinase from N. crassa acetylglutamate kinase appears to be an octamer.; Function: Acetylglutamate kinase from N. crassa is a regulatory enzyme and has been shown to be feedback-inhibited by arginine.; Function: Acetylglutamate kinase is involved in arginine biosynthesis in N. crassa.; Localization: Acetylglutamate kinase from N. crassa has been shown to be a soluble matrix enzyme in mitochondria.; Title: strong similarity to N-acetylglutamate kinase AGK - Neurospora crassa; localisation:mitochondrion; See PMID 2420793; See PMID 2987210; See PMID 6251078; uncharacterized protein 379487 4980179 An03g01910 Aspergillus niger uncharacterized protein XP_001390092.1 377982 R 5061 CDS An03g01920 84590641 complement(join(379759..379774,379884..380083,380163..380490,380534..380983,381108..381190)) VI 1 NT_166520.1 Remark: the human HSKM-B gene is expressed in human liver cancer tissue.; Remark: the matching coding sequence of patent WO200058473-A2 is identical to the sequence of the human HSKM-B.; Remark: there are no further informations about the patent available.; Title: similarity to human ORFX ORF2524 polypeptide sequence SEQ ID NO:5048 from patent WO200058473-A2 - Homo sapiens; uncharacterized protein 381190 84590641 An03g01920 Aspergillus niger uncharacterized protein XP_059600244.1 379759 R 5061 CDS An03g01930 84590642 join(381500..381599,381654..381724,382111..382240,382336..382394,382517..382600) VI 1 NT_166520.1 hypothetical protein 382600 84590642 An03g01930 Aspergillus niger hypothetical protein XP_059600245.1 381500 D 5061 CDS An03g01940 4980182 join(382915..383326,383379..383569,383668..383745) VI 1 NT_166520.1 Title: weak similarity to puromycin N-acetyl transferase pac - Streptomyces alboniger; uncharacterized protein 383745 4980182 An03g01940 Aspergillus niger uncharacterized protein XP_001390095.3 382915 D 5061 CDS An03g01950 4980183 384425..385429 VI 1 NT_166520.1 Title: similarity to hypothetical conserved protein encoded by the gene CC3732 - Caulobacter crescentus; uncharacterized protein 385429 4980183 An03g01950 Aspergillus niger uncharacterized protein XP_001390096.1 384425 D 5061 CDS An03g01960 84590643 complement(join(385593..385669,385716..385805,385889..385952)) VI 1 NT_166520.1 Title: questionable ORF; uncharacterized protein 385952 84590643 An03g01960 Aspergillus niger uncharacterized protein XP_059600246.1 385593 R 5061 CDS An03g01970 84590644 complement(join(387005..387400,387482..387550,387635..387703)) VI 1 NT_166520.1 hypothetical protein 387703 84590644 An03g01970 Aspergillus niger hypothetical protein XP_059600247.1 387005 R 5061 CDS An03g02000 4980188 complement(join(389357..389881,389920..389928,390052..390322,390372..390545,390606..390757,390829..391398,391468..391590)) VI 1 NT_166520.1 Function: nirA of A. nidulans encodes a transcription factor with a GAL4-type zinc finger domain.; Function: nirA of A. nidulans is a pathway-specific regulatory gene of nitrate assimilation.; Phenotype: mutations in nirA of A. nidulans affect the transcription levels of niiA and niaD (a nitrite and a nitrate reductase, respectively).; Remark: Emericella nidulans = Aspergillus nidulans.; Remark: an alternate name for nitrate assimilation regulatory protein nirA is transcription factor nirA.; Title: strong similarity to nitrate assimilation regulatory protein nirA - Aspergillus nidulans; nucleus; See PMID 1538701; See PMID 1990284; See PMID 347305; uncharacterized protein 391590 4980188 An03g02000 Aspergillus niger uncharacterized protein XP_059600248.1 389357 R 5061 CDS An03g02010 84590645 complement(join(391764..391945,392026..392292,392554..392681,392805..392899)) VI 1 NT_166520.1 hypothetical protein 392899 84590645 An03g02010 Aspergillus niger hypothetical protein XP_059600249.1 391764 R 5061 CDS An03g02020 84590646 join(393138..393228,393311..393413,393634..393821,393936..394138) VI 1 NT_166520.1 hypothetical protein 394138 84590646 An03g02020 Aspergillus niger hypothetical protein XP_059600250.1 393138 D 5061 CDS An03g02030 84590647 join(394441..394641,394710..394979) VI 1 NT_166520.1 Title: weak similarity to tissue plasminogen activator mutant 2K1 from patent WO8907146-A - Homo sapiens; uncharacterized protein 394979 84590647 An03g02030 Aspergillus niger uncharacterized protein XP_059600251.1 394441 D 5061 CDS An03g02040 4980192 complement(join(395419..395780,395842..396547,396603..396821)) VI 1 NT_166520.1 Catalytic activity: S-Adenosyl-L-methionine + Phospholipid olefinic fatty acid = S-Adenosyl-L-homocysteine + Phospholipid cyclopropane fatty acid.; Function: the cyclopropane fatty acid (CFA) synthase of E. coli catalyzes the methylenation of the unsaturated moieties of phospholipids in a phospholipid bilayer.; Remark: overproduction of the CFA-synthase of E. coli causes abnormally high levels of CFA in membrane phospholipid but no discernable growth perturbation.; Title: strong similarity to cyclopropane-fatty-acyl-phospholipid synthase - Escherichia coli; See PMID 6325391; See PMID 7024727; See PMID 380648; See PMID 1445840; uncharacterized protein 396821 4980192 An03g02040 Aspergillus niger uncharacterized protein XP_059600252.1 395419 R 5061 CDS An03g02050 84590648 join(397626..397743,398113..398418,398515..398858) VI 1 NT_166520.1 Similarity: the similarity between the two A. niger proteins is restricted to a stretch of about 100 amino acids.; Title: weak similarity to hypothetical protein encoded by An06g02100 - Aspergillus niger; uncharacterized protein 398858 84590648 An03g02050 Aspergillus niger uncharacterized protein XP_059600253.1 397626 D 5061 CDS An03g02060 4980194 join(399092..399508,399551..399711,399762..399925,399974..400221,400274..400588) VI 1 NT_166520.1 Catalytic activity: trans,trans-Farnesyl diphosphate + Isopentenyl diphosphate = Pyrophosphate + Geranylgeranyl diphosphate.; Function: the albino-3 gene of N. crassa encodes the carotenoid biosynthetic enzyme geranylgeranyl-pyrophosphate synthetase.; Induction: the albino-3 gene is not expressed in the dark but its transcription is induced by blue light.; Remark: the synonym for albino-3 from N. crassa is al-3.; Title: strong similarity to geranylgeranyl pyrophosphate synthase albino-3 - Neurospora crassa; See PMID 1826006; See PMID 8350190; uncharacterized protein 400588 4980194 An03g02060 Aspergillus niger uncharacterized protein XP_059600254.1 399092 D 5061 CDS An03g02070 4980195 complement(join(400978..401341,401418..401569,401691..401809,401868..402011,402064..402103)) VI 1 NT_166520.1 Title: similarity to hypothetical protein CAD11794.1 - Neurospora crassa; uncharacterized protein 402103 4980195 An03g02070 Aspergillus niger uncharacterized protein XP_059600255.1 400978 R 5061 CDS An03g02080 4980196 join(402751..403131,403190..403446,403509..403591,403654..403965,404025..404383) VI 1 NT_166520.1 Catalytic activity: (1,4-alpha-D-Galacturonide)n + H2O = (1,4-alpha-D-Galacturonide)n-1 + D-Galacturonate.; Function: The enzyme pgaX from A. tubingensis has been characterized as an exopolygalacturonase [poly(1,4-alpha-D-galacturonide)galacturonohydrolase] that cleaves monomer units from the non-reducing end of the substrate molecule.; Induction: Expression of the pgaX gene from A. tubingensis is inducible with galacturonic acid and is subject to catabolite repression.; Title: strong similarity to exopolygalacturonase pgaX - Aspergillus tubingensis; extracellular/secretion proteins; See PMID 8856078; uncharacterized protein 404383 4980196 An03g02080 Aspergillus niger uncharacterized protein XP_001390107.3 402751 D 5061 CDS An03g02090 4980197 complement(join(405300..405556,405604..406504,406565..406630)) VI 1 NT_166520.1 Remark: the matching coding sequence was isolated by RT-PCR on all of the mRNA from A. thaliana.; Remark: there are no further informations about the patent available.; Similarity: the ORF encoded protein shows also similarities to monooxygenases.; Title: similarity to protein fragment SEQ ID NO:50322 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 406630 4980197 An03g02090 Aspergillus niger uncharacterized protein XP_001390108.1 405300 R 5061 CDS An03g02100 4980198 join(406942..407236,407291..408003) VI 1 NT_166520.1 Function: the lipase lipP from Pseudomonas shows high activity towards short-chain to medium-chain fatty acids and 1,3-positional specificity towards triolein.; Repression: the lipase lipP from Pseudomonas is strongly inhibited by zinc, cupric, ferric and mercury ions but is not affected by phenylmethylsulfonyl fluoride and bisnitrophenyl phosphate.; Similarity: lipP from Pseudomonas belongs to the 'GDXG' family of lipolytic enzymes.; Title: strong similarity to cold-adapted lipase lipP - Pseudomonas sp.; See PMID 9464382; uncharacterized protein 408003 4980198 An03g02100 Aspergillus niger uncharacterized protein XP_001390109.3 406942 D 5061 CDS An03g02110 4980199 complement(join(408414..408754,408811..409030,409104..409598)) VI 1 NT_166520.1 Function: A ketoreductase is capable of reducing a variety of alpha-ketolactones, alpha-ketolactams and diketones.; Remark: The matched sequence of patent EP918090-A2 represents the putative ketoreductase of S. cerevisiae YDR541c.; Title: strong similarity to ketoreductase YDR541c from patent EP918090-A2 - Saccharomyces cerevisiae; uncharacterized protein 409598 4980199 An03g02110 Aspergillus niger uncharacterized protein XP_001390110.1 408414 R 5061 CDS An03g02120 4980200 complement(join(409758..409953,410006..410091,410152..410217,410269..410942,410997..411146,411198..411306,411366..411521)) VI 1 NT_166520.1 Complex: Dal5 from S. cerevisiae is a component of the allantoate transport system.; Induction: the DAL5 gene is constitutively expressed in S. cerevisiae.; Remark: the Dal5 protein from S. cerevisiae is highly hydrophobic.; Remark: the synonym for Dal5 from S. cerevisiae is YLL055w.; Similarity: Dal5 from S. cerevisiae is a member of the allantoate family of the major facilitator superfamily (MFS).; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 3275614; See PMID 3301804; See PMID 10869563; uncharacterized protein 411521 4980200 An03g02120 Aspergillus niger uncharacterized protein XP_001390111.1 409758 R 5061 CDS An03g02130 4980201 join(411863..412171,412233..412430,412501..412855,412904..413220,413372..413557) VI 1 NT_166520.1 Catalytic activity: salicylate + NADH + O2 = catechol + NAD+ + H2O + CO2.; Pathway: nahpthalene catabolism and phenylalanine metabolism.; Remark: nahG from P. putida catalyzes the formation of catechol from salicylate, a key intermediate in naphthalene catabolism.; Similarity: belongs to the tetracycline 6-hydroxylase family.; Title: strong similarity to salicylate hydroxylase nahG - Pseudomonas putida; See PMID 1993181; See PMID 8328809; See PMID 296054; uncharacterized protein 413557 4980201 An03g02130 Aspergillus niger uncharacterized protein XP_001390112.3 411863 D 5061 CDS An03g02140 4980202 complement(join(413943..414004,414146..415045,415099..415658,415718..415838,415891..415933,415999..416040)) VI 1 NT_166520.1 Function: Uga3 of S. cerevisiae is required for GABA-dependent induction of GABA catabolic enzymes and a GABA-specific permease.; Remark: the synonym for Uga3 from S. cerevisiae is YDL170w.; Title: similarity to regulator protein Uga3 -Saccharomyces cerevisiae; See PMID 2109179; See PMID 10713424; uncharacterized protein 416040 4980202 An03g02140 Aspergillus niger uncharacterized protein XP_059600256.1 413943 R 5061 CDS An03g02150 4980203 complement(join(416856..417819,417877..417884)) VI 1 NT_166520.1 Title: weak similarity to bacteriochlorophyll c synthase bchK - Chlorobium tepidum; uncharacterized protein 417884 4980203 An03g02150 Aspergillus niger uncharacterized protein XP_059600257.1 416856 R 5061 CDS An03g02160 4980204 complement(418863..419870) VI 1 NT_166520.1 Catalytic activity: UDPglucose = UDPgalactose.; Cofactor: NAD+.; Phenotype: the gal10 deletion mutant of S. cerevisiae is viable but cannot utilize galactose.; Remark: UDP-glucose 4-epimerase from Saccharomyces was inactivated both in vivo and in vitro (crude extracts) by L-arabinose or D-xylose.; Similarity: Gal10 from S. cerevisiaebelongs to the UDPglucose 4-epimerase family.; Title: similarity to UDP-glucose 4-epimerase Gal10 -Saccharomyces cerevisiae; See PMID 3333299; See PMID 6292668; See PMID 6987227; uncharacterized protein 419870 4980204 An03g02160 Aspergillus niger uncharacterized protein XP_001390115.1 418863 R 5061 CDS An03g02170 84590649 complement(join(419938..420276,420610..420680,420795..420909,421000..421031,421156..421240)) VI 1 NT_166520.1 hypothetical protein 421240 84590649 An03g02170 Aspergillus niger hypothetical protein XP_059600258.1 419938 R 5061 CDS An03g02180 4980206 421362..422357 VI 1 NT_166520.1 Remark: about the patent is no further information available.; Title: strong similarity to hydrophobic domain protein from patent WO200029448-A2 - Homo sapiens; uncharacterized protein 422357 4980206 An03g02180 Aspergillus niger uncharacterized protein XP_001390117.1 421362 D 5061 CDS An03g02190 4980207 complement(join(423387..423814,423883..424571,424621..424877,424931..425233)) VI 1 NT_166520.1 Function: Sut1 from P. stipidis transports glucose and is also able to transport xylose and other monosaccharides.; Function: when SUT1 from P. stipidis is expressed in a S. cerevisiae hxt (hexose transporter) null mutant strain that is unable to take up monosaccharides, Sut1 restored growth on glucose.; Induction: in P. stipitis, transcription of SUT1 was strongly induced by glucose and was independent of the oxygen supply.; Similarity: Sut1 from P. stipidis show sequence similarities to the S. cerevisiae hexose transporter family and to monosaccharide transporters of other organisms.; Title: strong similarity to sugar transporter Sut1 -Pichia stipitis; plasma membrane; See PMID 10048030; uncharacterized protein 425233 4980207 An03g02190 Aspergillus niger uncharacterized protein XP_001390118.1 423387 R 5061 CDS An03g02200 84590650 complement(join(425260..425432,425518..425632,425720..425932,426056..426133)) VI 1 NT_166520.1 Title: weak similarity to hypothetical protein encoded by ORF of clone HEMBA1003229 - Homo sapiens; uncharacterized protein 426133 84590650 An03g02200 Aspergillus niger uncharacterized protein XP_059600259.1 425260 R 5061 CDS An03g02220 84590651 complement(join(427731..427881,428217..428332,428369..428551)) VI 1 NT_166520.1 hypothetical protein 428551 84590651 An03g02220 Aspergillus niger hypothetical protein XP_059600260.1 427731 R 5061 CDS An03g02230 4980211 complement(join(428852..429022,429106..429675)) VI 1 NT_166520.1 hypothetical protein 429675 4980211 An03g02230 Aspergillus niger hypothetical protein XP_001390121.3 428852 R 5061 CDS An03g02240 4980212 join(430297..430305,430545..431405) VI 1 NT_166520.1 hypothetical protein 431405 4980212 An03g02240 Aspergillus niger hypothetical protein XP_001390122.3 430297 D 5061 CDS An03g02250 84590652 join(432581..432652,432708..433059,433353..433429) VI 1 NT_166520.1 Title: weak similarity to antigenic protein t01A.aa BB001 from patent WO9859071-A1 - Borrelia burgdorferi; uncharacterized protein 433429 84590652 An03g02250 Aspergillus niger uncharacterized protein XP_059600261.1 432581 D 5061 CDS An03g02260 4980214 join(434072..434258,434325..435145) VI 1 NT_166520.1 Function: the matched gene encode a C. glutamicum homeostasis and adaptation (HA) protein.; Remark: no further information about the patent is available.; Title: similarity to homeostasis and adaptation protein sequence SEQ ID NO:228 from patent WO200100842-A2 -Corynebacterium glutamicum; uncharacterized protein 435145 4980214 An03g02260 Aspergillus niger uncharacterized protein XP_059600262.1 434072 D 5061 CDS An03g02270 4980215 complement(join(435741..436005,436124..436497)) VI 1 NT_166520.1 Complex: voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2,beta and delta subunits in a 1:1:1:1 ratio.; Function: the channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit.; Function: voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes,including muscle contraction, gene expression, cell motility, cell division and cell death.; Similarity: Fgalpha1S from R. catesbeiana belongs to the calcium channel alpha-1 subunits family.; Title: similarity to dihydropyridine receptor Fgalpha1S - Rana catesbeiana; plasma membrane; See PMID 9738021; uncharacterized protein 436497 4980215 An03g02270 Aspergillus niger uncharacterized protein XP_001390125.1 435741 R 5061 CDS An03g02280 4980216 complement(join(436707..436979,437163..438224)) VI 1 NT_166520.1 Function: ssuD catalysis is absolutely dependent on FMNH(2) and oxygen.; Function: ssuD from E. coli encodes a reduced flavin mononucleotide-dependent alkanesulfonate monooxygenase; Function: ssuD from E. coli is responsible for the desulfonation of alkanesulfonates.; Function: the purified enzyme ssuD from E. coli catalyzed the conversion of pentanesulfonic acid to sulfite and pentaldehyde; Function: the purified enzyme ssuD from E. coli is able to desulfonate a wide range of sulfonated substrates including C-2 to C-10 unsubstituted linear alkanesulfonates, substituted ethanesulfonic acids and sulfonated buffers.; Title: strong similarity to FMNH2-dependent aliphatic sulfonate monooxygenase ssuD - Escherichia coli; See PMID 10480865; See PMID 10506196; uncharacterized protein 438224 4980216 An03g02280 Aspergillus niger uncharacterized protein XP_001390126.3 436707 R 5061 CDS An03g02290 84590653 join(439122..439412,439623..439730,439793..439900) VI 1 NT_166520.1 Similarity: the similarities are mainly based on repetetive structures.; Title: weak similarity to transcription factor Brn-2 - Rattus norvegicus; uncharacterized protein 439900 84590653 An03g02290 Aspergillus niger uncharacterized protein XP_059600263.1 439122 D 5061 CDS An03g02300 4980218 441218..442324 VI 1 NT_166520.1 Catalytic activity: D-Threonine = Glycine + Acetaldehyde.; Function: the metal-activated pyridoxal enzyme from Arthrobacter is a low specificity D-threonine aldolase.; Remark: Mn2+ ion is an activator of the metal-activated pyridoxal enzyme from Arthrobacter.; Title: strong similarity to metal-activated pyridoxal enzyme D-threonine aldolase - Arthrobacter sp.; See PMID 9642221; uncharacterized protein 442324 4980218 An03g02300 Aspergillus niger uncharacterized protein XP_001390128.1 441218 D 5061 CDS An03g02310 84590654 join(443034..443083,443165..443278,443353..443533,443609..443850,443951..444191) VI 1 NT_166520.1 Title: weak similarity to protein fragment SEQ ID NO:50343 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 444191 84590654 An03g02310 Aspergillus niger uncharacterized protein XP_059600264.1 443034 D 5061 CDS An03g02320 4980220 join(444298..444469,444528..444680,444745..446276) VI 1 NT_166520.1 Catalytic activity: Phenol + NADPH + O2 = Catechol + NADP+ + H2O.; Cofactor: FAD flavoprotein.; Remark: phenol hydroxylases are involved in degradation of phenylalanine, toluene and gamma-hexachlorocyclohexane.; Remark: the phenol hydroxylase from T. cutaneum catalyzes the first step of phenol biodegradation.; Repression: the phenol hydroxylase from T. cutaneum is inhibited by excess phenol.; Similarity: the phenol hydroxylase from T. cutaneum belongs to the PHEA/TFDB family of FAD monooxygenases.; Title: strong similarity to phenol hydroxylase -Trichosporon cutaneum; cytoplasm; See PMID 9634698; See PMID 1429434; uncharacterized protein 446276 4980220 An03g02320 Aspergillus niger uncharacterized protein XP_001390130.1 444298 D 5061 CDS An03g02330 4980221 join(446850..446986,447053..447699,447771..447907) VI 1 NT_166520.1 Catalytic activity: Urate + O2 + H2O = 5-hydroxyisourate + H(2)O(2).; Remark: 5-hydroxyisourate decompose to form allantoin.; Similarity: the matched protein belongs to the uricase family.; Title: strong similarity to urate oxidase from patent EP408461-A - Aspergillus flavus; peroxisome; See PMID 1339455; uncharacterized protein 447907 4980221 An03g02330 Aspergillus niger uncharacterized protein XP_001390131.1 446850 D 5061 CDS An03g02350 84590655 join(450575..450732,451391..451621,451683..451734,451823..451926,452150..452275,452364..452442,452568..452672) VI 1 NT_166520.1 hypothetical protein 452672 84590655 An03g02350 Aspergillus niger hypothetical protein XP_059600265.1 450575 D 5061 CDS An03g02360 4980224 join(452966..453236,453292..453365,453441..453464) VI 1 NT_166520.1 Title: weak similarity to spore-wall fungal hydrophobin dewA - Aspergillus nidulans; uncharacterized protein 453464 4980224 An03g02360 Aspergillus niger uncharacterized protein XP_001390133.1 452966 D 5061 CDS An03g02370 84590656 join(454340..455006,455211..455661,455698..455860) VI 1 NT_166520.1 Title: weak similarity to rinder-pest virus nucleoprotein from patent JP05322898-A - Rinderpest virus; uncharacterized protein 455860 84590656 An03g02370 Aspergillus niger uncharacterized protein XP_059600266.1 454340 D 5061 CDS An03g02380 4980226 join(456445..457447,457504..457772,457845..459329) VI 1 NT_166520.1 Phenotype: qde-2 mutants of N. crassa are defective in transgene-induced gene silencing.; Remark: in N. crassa QDE-2 is required for quelling.; Title: strong similarity to protein involved in post-transcriptional gene silencing Qde-2 - Neurospora crassa; nucleus; See PMID 9294193; uncharacterized protein 459329 4980226 An03g02380 Aspergillus niger uncharacterized protein XP_059600267.1 456445 D 5061 CDS An03g02390 84590657 join(459670..459771,459896..459954,460046..460228,460483..460600) VI 1 NT_166520.1 hypothetical protein 460600 84590657 An03g02390 Aspergillus niger hypothetical protein XP_059600268.1 459670 D 5061 CDS An03g02400 4980228 join(461022..461292,461372..461445,461542..461592) VI 1 NT_166520.1 Induction: the mRNA of dewA from E. nidulans accumulates preferentially during asexual sporulation.; Localization: dewA from E. nidulans is present in the spore wall, but not in the walls of germ tubes, hyphae or cells of the spore-producing conidiophore.; Phenotype: sporulating colonies of dewA null mutants wetted more rapidly with detergent solutions than did the wild type.; Remark: Emericella nidulans = Aspergillus nidulans.; Remark: the synonym for dewA from E. nidulans is CAN4.; Similarity: dewA from E. nidulans belongs to the fungal hydrophobins, a group of small, hydrophobic cell wall proteins.; Title: strong similarity to spore-wall fungal hydrophobin dewA - Aspergillus nidulans; cell wall; See PMID 7651135; uncharacterized protein 461592 4980228 An03g02400 Aspergillus niger uncharacterized protein XP_001390137.1 461022 D 5061 CDS An03g02410 84590658 complement(join(462849..463061,463394..463459)) VI 1 NT_166520.1 hypothetical protein 463459 84590658 An03g02410 Aspergillus niger hypothetical protein XP_059600269.1 462849 R 5061 CDS An03g02420 84590659 join(463743..463858,463946..464035,464055..464152,464386..464499,464872..464985,465079..465365) VI 1 NT_166520.1 hypothetical protein 465365 84590659 An03g02420 Aspergillus niger hypothetical protein XP_059600270.1 463743 D 5061 CDS An03g02430 4980231 join(465546..466110,466152..467053) VI 1 NT_166520.1 Catalytic activity: D-Mannitol + NAD = D-Mannose + NADH.; Function: The purified enzyme MtlD from P. fluorescens was shown to be a polyol dehydrogenase with a broad substrate spectrum oxidizing efficiently mannitol,sorbitol and arabitol.; Remark: EC 1. 1. 1. 255 (not yet present in EC catalogue).; Remark: The enzyme is specific for NAD and does not use NADP.; Title: strong similarity to mannitol dehydrogenase mtlD - Pseudomonas fluorescens; See PMID 9116029; uncharacterized protein 467053 4980231 An03g02430 Aspergillus niger uncharacterized protein XP_059600271.1 465546 D 5061 CDS An03g02450 84590660 complement(join(469108..469284,469350..469488,469642..469877)) VI 1 NT_166520.1 hypothetical protein 469877 84590660 An03g02450 Aspergillus niger hypothetical protein XP_059600272.1 469108 R 5061 CDS An03g02460 84590661 470566..470916 VI 1 NT_166520.1 hypothetical protein 470916 84590661 An03g02460 Aspergillus niger hypothetical protein XP_059600273.1 470566 D 5061 CDS An03g02480 4980236 complement(471680..472696) VI 1 NT_166520.1 Remark: the human PRO polypeptides have cytostatic activity.; Remark: there is no further information about the patent available.; Title: similarity to protein PRO1072 encoded by the sequence SEQ ID NO:303 from patent WO200053756-A2 - Homo sapiens; uncharacterized protein 472696 4980236 An03g02480 Aspergillus niger uncharacterized protein XP_001390143.1 471680 R 5061 CDS An03g02490 4980237 join(473662..473729,473802..473922,473975..474103,474170..474640) VI 1 NT_166520.1 Catalytic activity: 2-Dehydro-3-deoxy-D-glucarate = Pyruvate + Tartronate semialdehyde.; Pathway: garL from E. coli catalizes the second step in the metabolism of d-galactarate.; Remark: garL from E. coli requires magnesium for activity.; Title: strong similarity to proliferation associated protein garL SEQ ID NO:257 from patent WO200044906-A2 -Escherichia coli; See PMID 10762278; uncharacterized protein 474640 4980237 An03g02490 Aspergillus niger uncharacterized protein XP_001390144.1 473662 D 5061 CDS An03g02500 4980238 complement(join(474869..475020,475081..475208,475302..475324,475398..475404,475563..475674,475704..475756,475809..475848,475890..475971,476027..476287,476434..476475)) VI 1 NT_166520.1 Remark: C. pneumoniae causes respiratory disease such as pneumonia and bronchitis and is thought to be a contributing factor in heart disease, sarcoidosis,sinusitis, purulent otitis media, erythema nodosum or pharyngitis.; Remark: there is no further information about the patent available.; Title: similarity to transmembrane protein from patent WO9927105-A2 - Chlamydia pneumoniae; uncharacterized protein 476475 4980238 An03g02500 Aspergillus niger uncharacterized protein XP_059600274.1 474869 R 5061 CDS An03g02510 4980239 complement(join(477498..478100,478160..479158)) VI 1 NT_166520.1 Title: weak similarity to hypothetical protein CAD70818.1 - Neurospora crassa; uncharacterized protein 479158 4980239 An03g02510 Aspergillus niger uncharacterized protein XP_001390146.1 477498 R 5061 CDS An03g02520 84590662 join(479459..479495,479588..480000) VI 1 NT_166520.1 hypothetical protein 480000 84590662 An03g02520 Aspergillus niger hypothetical protein XP_059600275.1 479459 D 5061 CDS An03g02525 84590663 join(480452..480510,480662..480870,480939..481270) VI 1 NT_166520.1 Title: similarity to hypothetical proteinase encoded by 2SC3B6.04c - Streptomyces coelicolor; uncharacterized protein 481270 84590663 An03g02525 Aspergillus niger uncharacterized protein XP_059600276.1 480452 D 5061 CDS An03g02530 4980242 join(481415..482087,482143..482221,482290..482350,482424..482597) VI 1 NT_166520.1 Title: similarity to hypothetical proteinase encoded by SCD8A.14c - Streptomyces coelicolor; uncharacterized protein 482597 4980242 An03g02530 Aspergillus niger uncharacterized protein XP_001390149.3 481415 D 5061 CDS An03g02540 4980243 complement(join(484586..485212,485288..485966,486018..486096,486159..486424,486488..486732,486820..488031,488263..488550,488606..488779)) VI 1 NT_166520.1 Remark: the B. cinerea ABC transporter BcatrB protects the fungal pathogen against antimicrobial substances (phytoalexine) which are produced by a plant in response to infection by fungi or bacteria and helps to defend the plant by inhibiting the growth of invading microbes.; Similarity: the predicted A. niger protein contains two conserved ABC transporter domains (aa 103-264, 743-932,PF00005).; Title: strong similarity to ABC transporter BcatrB -Botrytis cinerea; See PMID 11310744; See PMID 11374155; uncharacterized protein 488779 4980243 An03g02540 Aspergillus niger uncharacterized protein XP_059600277.1 484586 R 5061 CDS An03g02550 4980244 join(489121..489282,489344..489908,489986..490143) VI 1 NT_166520.1 Function: the C. aquaticum levodione reductase catalyzes regio- and stereoselective reduction of levodione ((6R)-2,2,6-Trimethyl-1,4-cyclohexanedione) to (4R,6R)-4-hydroxy-2,2,6-trimethylcyclohexanone (actinol).; Induction: the C. aquaticum levodione reductase is strongly activated by monovalent cations like NH4+, K+ and Na+.; Similarity: the C. aquaticum levodione reductase posseses a consensus sequence (aa 41-229) of the very large family of short chain dehydrogenases/reductases (SDR), a familiy of NAD- or NADP-dependent oxidoreductases.; Title: similarity to levodione reductase lvr -Corynebacterium aquaticum; See PMID 10508066; uncharacterized protein 490143 4980244 An03g02550 Aspergillus niger uncharacterized protein XP_001390151.1 489121 D 5061 CDS An03g02560 4980245 complement(join(490371..492353,492410..492564,492598..492707,492785..492822,492898..493041,493073..493204)) VI 1 NT_166520.1 Similarity: the ORF shows similarity to another A. niger protein. The other protein displays similarity to acetate regulatory DNA binding protein FacB of A. nidulans.; Title: strong similarity to hypothetical protein encoded by An15g04320 - Aspergillus niger; uncharacterized protein 493204 4980245 An03g02560 Aspergillus niger uncharacterized protein XP_001390152.3 490371 R 5061 CDS An03g02570 4980246 complement(join(493657..494072,494132..495455)) VI 1 NT_166520.1 Phenotype: the expression of C. maltosa C450 52A3-a in S. cerevisiae resulted in a massive proliferation of the endoplasmatic reticulum.; Remark: expression of the C. maltosa C450 52A3-a in S. cerevisiae resulted in the formation of intact microsomal P-450 systems catalyzing the hydroxylation of n-hexadecane and lauric acid.; Similarity: the C. maltosa C450 52A3-a belong to the CYP52 multigene family occurring in the alkane-assimilating yeast C. maltosa.; Title: strong similarity to cytochrome P450 52A3-a -Candida maltosa; See PMID 1935996; uncharacterized protein 495455 4980246 An03g02570 Aspergillus niger uncharacterized protein XP_001390153.3 493657 R 5061 CDS An03g02580 4980247 497186..497962 VI 1 NT_166520.1 Title: similarity to hypothetical protein SC4B10.33 - Streptomyces coelicolor; uncharacterized protein 497962 4980247 An03g02580 Aspergillus niger uncharacterized protein XP_001390154.1 497186 D 5061 CDS An03g02590 84590664 complement(join(498710..498953,499114..499171,499230..499317)) VI 1 NT_166520.1 hypothetical protein 499317 84590664 An03g02590 Aspergillus niger hypothetical protein XP_059603562.1 498710 R 5061 CDS An03g02600 4980249 join(499694..499762,499828..499964,500051..500447,500539..500889) VI 1 NT_166520.1 Function: S. pombe ptc3 encodes one of three protein phosphatase 2C homologs in the fission yeast genome participating in osmoregulation and cell shape control.; Title: weak similarity to protein phosphatase 2C tc3p - Schizosaccharomyces pombe; uncharacterized protein 500889 4980249 An03g02600 Aspergillus niger uncharacterized protein XP_059603563.1 499694 D 5061 CDS An03g02610 4980250 join(501428..501774,501829..502502,502589..502629) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein SPBC1604.01 - Schizosaccharomyces pombe; uncharacterized protein 502629 4980250 An03g02610 Aspergillus niger uncharacterized protein XP_059603564.1 501428 D 5061 CDS An03g02620 4980251 complement(join(503871..504112,504196..505246)) VI 1 NT_166520.1 Title: strong similarity to protein fragment SEQ ID NO:34719 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 505246 4980251 An03g02620 Aspergillus niger uncharacterized protein XP_001390158.1 503871 R 5061 CDS An03g02630 4980252 complement(join(505612..505697,505761..506421)) VI 1 NT_166520.1 Remark: the C. lindemuthianum homolog CIH1 is an oxidatively cross-linked proline-rich protein expressed only during the biotrophic stage of infection of Phaseolus vulgaris.; Title: similarity to hypothetical glycoprotein CIH1 - Colletotrichum lindemuthianum; uncharacterized protein 506421 4980252 An03g02630 Aspergillus niger uncharacterized protein XP_001390159.3 505612 R 5061 CDS An03g02635 84590665 complement(join(508155..508323,508360..508559,508679..508729)) VI 1 NT_166520.1 hypothetical protein 508729 84590665 An03g02635 Aspergillus niger hypothetical protein XP_059603565.1 508155 R 5061 CDS An03g02640 84590666 complement(<509013..512043) VI 1 NT_166520.1 Catalytic activity: ATP + {deoxyribonucleotide}(N) + {deoxyribonucleotide}(M) <=> AMP + diphosphate + {deoxyribonucleotide}(N+M).; Function: the C. albicans homolog CaLIG4 encodes an ATP-dependent DNA ligase.; Induction: C. albicans CaLIG4 is expressed in a cell cycle-dependent manner.; Remark: a putative sequencing error results in an frameshift.; Similarity: the C. albicans homolog shows significant similarity to ligase IV from both S. cerevisiae and humans.; Title: strong similarity to DNA ligase CaLIG4 -Candida albicans [putative frameshift]; putative frameshift; uncharacterized protein 512043 84590666 An03g02640 Aspergillus niger uncharacterized protein XP_059603566.1 509013 R 5061 CDS An03g02650 4980255 complement(join(512615..514261,514334..514360)) VI 1 NT_166520.1 Function: the L. pneumophila homolog dotA belongs to the group of proteins required for phagosome formation during infection of alveolar macrophages. in addition to those Dot/Icm genes that encode the core transport apparatus, a subsets of genes are required for pore formation and modulation of phagosome trafficking.; Title: strong similarity to inhibitor of endosome-lysosome fusion dlpA - Legionella pneumophila; extracellular/secretion proteins; uncharacterized protein 514360 4980255 An03g02650 Aspergillus niger uncharacterized protein XP_001390162.3 512615 R 5061 CDS An03g02660 4980256 complement(join(514966..515119,515156..517494,517525..517816,518002..518072)) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein 17E5.30 - Neurospora crassa; uncharacterized protein 518072 4980256 An03g02660 Aspergillus niger uncharacterized protein XP_059603567.1 514966 R 5061 CDS An03g02670 4980257 complement(518632..521718) VI 1 NT_166520.1 Function: the S. cerevisiae homolog Fig4p is required for the mating process in response to direct cell-cell comunication.; Induction: S. cerevisiae FIG4 expression is induced by mating pheromone alpha-factor.; Title: strong similarity to hypothetical protein involved in mating Fig4 - Saccharomyces cerevisiae; uncharacterized protein 521718 4980257 An03g02670 Aspergillus niger uncharacterized protein XP_001390164.1 518632 R 5061 CDS An03g02680 4980258 complement(join(522284..522732,522806..523193)) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein encoded by An12g02060 - Aspergillus niger; uncharacterized protein 523193 4980258 An03g02680 Aspergillus niger uncharacterized protein XP_001390165.1 522284 R 5061 CDS An03g02690 4980259 complement(524337..525932) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein SCF91.02c - Streptomyces coelicolor; uncharacterized protein 525932 4980259 An03g02690 Aspergillus niger uncharacterized protein XP_001390166.1 524337 R 5061 CDS An03g02700 4980260 complement(527422..529953) VI 1 NT_166520.1 Function: TRK2 encodes the low-affinity K+ transporter in S. cerevisiae.; Title: strong similarity to potassium transport protein Trk2 - Saccharomyces cerevisiae; uncharacterized protein 529953 4980260 An03g02700 Aspergillus niger uncharacterized protein XP_059603568.1 527422 R 5061 CDS An03g02710 84590667 530913..531161 VI 1 NT_166520.1 hypothetical protein 531161 84590667 An03g02710 Aspergillus niger hypothetical protein XP_059603569.1 530913 D 5061 CDS An03g02720 4980262 complement(531359..532999) VI 1 NT_166520.1 Title: similarity to hypothetical myb-related protein YDR026c - Saccharomyces cerevisiae; uncharacterized protein 532999 4980262 An03g02720 Aspergillus niger uncharacterized protein XP_001390169.1 531359 R 5061 CDS An03g02730 84590668 join(534063..534130,534192..534267,534297..534304,534343..534361) VI 1 NT_166520.1 hypothetical protein 534361 84590668 An03g02730 Aspergillus niger hypothetical protein XP_059603570.1 534063 D 5061 CDS An03g02740 84590669 join(534509..534596,534801..535054,535093..535159,535292..535517,535558..535685,535774..535895) VI 1 NT_166520.1 hypothetical protein 535895 84590669 An03g02740 Aspergillus niger hypothetical protein XP_059603571.1 534509 D 5061 CDS An03g02750 4980265 complement(536225..537184) VI 1 NT_166520.1 Remark: the N. crassa homolog B11A5. 90 is significantly longer.; Title: strong similarity to hypothetical protein B11A5.90 - Neurospora crassa; uncharacterized protein 537184 4980265 An03g02750 Aspergillus niger uncharacterized protein XP_001390172.1 536225 R 5061 CDS An03g02770 4980267 join(538595..538609,538681..540056,540107..540371) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein YLR361c - Saccharomyces cerevisiae; uncharacterized protein 540371 4980267 An03g02770 Aspergillus niger uncharacterized protein XP_001390173.1 538595 D 5061 CDS An03g02780 4980268 complement(join(540677..541166,541232..541626,541749..541940)) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein 15E6.170 - Neurospora crassa; uncharacterized protein 541940 4980268 An03g02780 Aspergillus niger uncharacterized protein XP_001390174.1 540677 R 5061 CDS An03g02790 84590670 complement(join(542581..542820,542864..543136)) VI 1 NT_166520.1 hypothetical protein 543136 84590670 An03g02790 Aspergillus niger hypothetical protein XP_059603572.1 542581 R 5061 CDS An03g02800 4980270 join(543354..543613,543662..543961,544024..544405) VI 1 NT_166520.1 Title: strong similarity to EST an_2890 -Aspergillus niger; uncharacterized protein 544405 4980270 An03g02800 Aspergillus niger uncharacterized protein XP_001390176.3 543354 D 5061 CDS An03g02810 4980271 545857..547341 VI 1 NT_166520.1 hypothetical protein 547341 4980271 An03g02810 Aspergillus niger hypothetical protein XP_001390177.1 545857 D 5061 CDS An03g02820 4980272 complement(547762..549549) VI 1 NT_166520.1 Function: the S. cerevisiae homolog Cvt17p is essential for degradation of subvacuolar vesicles which were derived from subcellular organells targeted for recycling in the vacuole under starvation conditions. CVT17 encodes a putative lipase, which conserved active-site serine motif is essential for this membrane lytic event.; Pathway: S. cerevisiae Cvt17p is involved in the cytoplasm to vacuole targeting (Cvt) pathway.; Title: strong similarity to hypothetical lipase Cvt17 - Saccharomyces cerevisiae; uncharacterized protein 549549 4980272 An03g02820 Aspergillus niger uncharacterized protein XP_001390178.1 547762 R 5061 CDS An03g02830 4980273 complement(join(550255..550296,550328..550532,550585..551143,551208..551343,551395..551527,551674..551693)) VI 1 NT_166520.1 Catalytic activity: Phosphatidyl-L-serine <=> phosphatidylethanolamine + CO(2).; Function: S. cerevisiae Psd2p is involved in the synthesis of phosphatidylethanolamine and may be involved in regulation of intracellular trafficking of phosphatidylserine.; Golgi; Remark: the S. cerevisiae homolog Psd2p is significantly longer.; Title: strong similarity to phosphatidylserine decarboxylase Psd2 - Saccharomyces cerevisiae; uncharacterized protein 551693 4980273 An03g02830 Aspergillus niger uncharacterized protein XP_059603573.1 550255 R 5061 CDS An03g02840 4980274 complement(join(552584..553283,553358..553416)) VI 1 NT_166520.1 Catalytic activity: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP(+) <=> 3-oxoacyl-[acyl-carrier protein] + NADPH.; Function: the B. subtilis homolog fabG encodes a 3-oxoacyl-[acyl-carrier-protein] reductase and is involved in biosynthesis of fatty acids.; Pathway: first reduction step in the fatty acid biosynthesis pathway.; Title: strong similarity to 3-oxoacyl-(acyl-carrier-protein) reductase fabG - Bacillus subtilis; uncharacterized protein 553416 4980274 An03g02840 Aspergillus niger uncharacterized protein XP_001390180.1 552584 R 5061 CDS An03g02850 4980275 complement(join(553829..553877,553962..554077,554157..554564,554638..554855,554922..554927,554993..555060,555112..555173)) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein F2I11-120 - Arabidopsis thaliana; uncharacterized protein 555173 4980275 An03g02850 Aspergillus niger uncharacterized protein XP_059600278.1 553829 R 5061 CDS An03g02860 84590671 complement(join(556369..556406,556650..557221,557277..557476)) VI 1 NT_166520.1 Phenotype: the S. cerevisiae SUR1 null mutant is viable, calcium sensitive at 37 degrees C on YPD but calcium tolerant at 26 degrees C, accumulates greatly reduced levels of several mannosylated sphingolipids.; Remark: alternate names for the S. cerevisiae SUR1 protein are BCL21, CSG1 and LPE15.; Remark: the S. cerevisiae SUR1 protein is thougt to be required for the mannosylation of inositolphosphorylceramide (IPC) to form mannosylinositolphosphorylceramide (MIPC).; Title: strong similarity to hypothetical protein EAA61879.1 - Aspergillus nidulans; uncharacterized protein 557476 84590671 An03g02860 Aspergillus niger uncharacterized protein XP_059600279.1 556369 R 5061 CDS An03g02870 4980277 complement(join(558450..558483,558535..558725,558799..559425,559483..559722)) VI 1 NT_166520.1 Title: strong similarity to hypothetical transmembrane protein L2185.03 - Leishmania major; uncharacterized protein 559722 4980277 An03g02870 Aspergillus niger uncharacterized protein XP_001390183.1 558450 R 5061 CDS An03g02880 4980278 complement(join(560549..561293,561358..561419,561470..561613,561675..561917,561970..562026,562215..562268,562466..562510,562697..563296,563419..563535)) VI 1 NT_166520.1 Similarity: the ORF shows strong similarity to another A. niger protein An08g04310. An08g04310, however,is much shorter than the ORF (271 compared to 688 amino acids).; Title: strong similarity to hypothetical protein CAD70545.1 - Neurospora crassa; uncharacterized protein 563535 4980278 An03g02880 Aspergillus niger uncharacterized protein XP_001390184.3 560549 R 5061 CDS An03g02890 4980279 complement(565107..>567857) VI 1 NT_166520.1 Function: the S. pombe rad13 is a single-stranded endonuclease involved in excisioin repair of DNA damaged with UV-light, bulky adducts and cross-linking agents.; Remark: ORF 5'truncated due to end of contig.; Similarity: the S. pombe rad13 is similar to other members of the XPG/rad2 familiy.; Title: strong similarity to DNA repair protein rad13p - Schizosaccharomyces pombe [truncated ORF]; See PMID 8464724; uncharacterized protein 567857 4980279 An03g02890 Aspergillus niger uncharacterized protein XP_001390185.3 565107 R 5061 CDS An03g02900 84590672 complement(<567958..568518) VI 1 NT_166520.1 Remark: ORF 3'truncated due to end of contig.; Title: strong similarity to excision repair protein rad13p - Schizosaccharomyces pombe [truncated ORF]; uncharacterized protein 568518 84590672 An03g02900 Aspergillus niger uncharacterized protein XP_059603574.1 567958 R 5061 CDS An03g02910 4980281 complement(join(569456..570862,570916..571110)) VI 1 NT_166520.1 hypothetical protein 571110 4980281 An03g02910 Aspergillus niger hypothetical protein XP_001390187.1 569456 R 5061 CDS An03g02920 4980282 571919..573205 VI 1 NT_166520.1 Remark: A. nidulans cnxABC is a difunctional proteins with two catalytic domains, CNXA and CNXC.; Remark: the Aspergillus nidulans cnxABC locus encodes a single protein with two catalytic domains,required for synthesis of the precursor Z, an intermediate in molybdenum cofactor biosynthesis.; Similarity: the A. nidulans CNXA domain is similar to the E. coli moaA gene product, while CNXC is similar to the E. coli moaC product.; Title: strong similarity to molybdopterin cofactor biosynthetic protein cnxABC - Aspergillus nidulans; See PMID 9353296; uncharacterized protein 573205 4980282 An03g02920 Aspergillus niger uncharacterized protein XP_001390188.1 571919 D 5061 CDS An03g02930 4980283 573581..575761 VI 1 NT_166520.1 Catalytic activity: the N. crassa amino-acid N-acetyltransferase converts Acetyl-CoA and L-glutamate to CoA and N-acetyl-L-glutamate.; Localization: the N. crassa amino-acid N-acetyltransferase is localised within the mitochondrial matrix where it is part of the Urea cycle and the metabolism of amino groups.; Remark: an alternative name for the N. crassa amino-acid N-acetyltransferase is acetylglutamate synthase.; Title: strong similarity to amino-acid N-acetyltransferase - Neurospora crassa; localisation:mitochondrion; See PMID 8939437; uncharacterized protein 575761 4980283 An03g02930 Aspergillus niger uncharacterized protein XP_001390189.1 573581 D 5061 CDS An03g02940 4980284 join(576705..577396,577462..577899,577959..578346,578402..578537,578608..579059) VI 1 NT_166520.1 Function: it is proposed that TamA serve as a co-activator of AreA, the major nitrogen regulatory protein in A. nidulans.; Localization: the GFP-TamA fusion protein is predominantly localised to the nucleus in the presence and absence of ammonium.; Remark: the tamA gene of A. nidulans contains a putative zinc cluster motif which is not required for gene function.; Similarity: the N-terminal region of the predicted A. niger protein contains a fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain.; Similarity: the tamA sequence shares significant homology with the UGA35/DAL81/DURL gene of S. cerevisiae.; Title: similarity to nitrogen regulatory protein tamA - Aspergillus nidulans; nucleus; See PMID 8655534; See PMID 11459183; uncharacterized protein 579059 4980284 An03g02940 Aspergillus niger uncharacterized protein XP_001390190.1 576705 D 5061 CDS An03g02950 4980285 complement(579753..581387) VI 1 NT_166520.1 Title: similarity to hypothetical protein B16B8.350 - Neurospora crassa; uncharacterized protein 581387 4980285 An03g02950 Aspergillus niger uncharacterized protein XP_001390191.1 579753 R 5061 CDS An03g02960 4980286 complement(join(582419..583992,584047..584227)) VI 1 NT_166520.1 Catalytic activity: the C. albicans beta-hexosamidase hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.; Function: the beta-hexosamidase is involved in the glycoprotein degradation, aminosugar metabolism,glycosaminoglycan degradation and sphingoglycolipid metabolism.; Remark: a possible sequencing error occured at position 26746 leading to a stop codon, 1 base has been replaced with N.; Remark: an alterante name for C. albicans beta-hexosamidase is N-acetyl-beta-glucosamidase.; Title: strong similarity to beta-hexosamidase HEX1 -Candida albicans [putative sequencing error]; extracellular/secretion proteins; putative sequencing error; See PMID 9385137; See PMID 8169213; uncharacterized protein 584227 4980286 An03g02960 Aspergillus niger uncharacterized protein XP_059603575.1 582419 R 5061 CDS An03g02970 4980287 584992..587784 VI 1 NT_166520.1 hypothetical protein 587784 4980287 An03g02970 Aspergillus niger hypothetical protein XP_001390193.1 584992 D 5061 CDS An03g02980 4980288 complement(join(588861..589155,589211..589242)) VI 1 NT_166520.1 Function: thioredoxin is involved in oxidative stress response and redox regulation.; Localization: the S. cerevisiae TRX1 and TRX2 are located in the cytoplasm, while TRX3 is located in the mitochondrion.; Remark: A. nidulans thioredoxin is an intercellular disulphide-reducing enzyme which exhibits an unusual fluorescence emission spectrum, characterized by a high contribution of tyrosine residues.; Remark: the amino acid sequence of A. nidulans thioredoxin was determined by automated Edman degradation.; Similarity: the A. nidulans thioreduxin displays a sequence similarity of 45% to at least one of three thioredoxin homologues in S. cerevisiae TRX1, TRX2 and TRX3.; Title: strong similarity to thioredoxin -Aspergillus nidulans; cytoplasm; See PMID 1459127; uncharacterized protein 589242 4980288 An03g02980 Aspergillus niger uncharacterized protein XP_001390194.1 588861 R 5061 CDS An03g02990 4980289 join(589893..590373,590437..591077,591135..591245) VI 1 NT_166520.1 Function: the K. lactis GNT1 protein plays a crucial role in the biosythesis of mannan chains to synthesise mannoproteins in the endoplasmatic reticulum.; Golgi; Remark: the genes for the Golgi apparatus N-acetylglucosaminyltransferase and the UDP-N-acetylglucosamine transporter are contiguous in Kluyveromyces lactis.; Title: similarity to alphaN-acetylglucosamine transferase GNT1 - Kluyveromyces lactis; See PMID 8650202; See PMID 10037760; uncharacterized protein 591245 4980289 An03g02990 Aspergillus niger uncharacterized protein XP_001390195.1 589893 D 5061 CDS An03g03000 4980290 join(592201..592383,592438..592537,592592..593847) VI 1 NT_166520.1 Pathway: molybdopterin biosynthesis is an evolutionarily conserved pathway present in eubacteria,archaea and eukaryotes, including humans.; Phenotype: genetic deficiencies of enzymes involved in molybdopterin biosynthesis in humans lead to a severe and usually fatal disease due to a combined deficiency of the molybdoenzymes sulphite oxidase, xanthine dehydrogenase and aldehyde oxidase.; Remark: an alternative name for E. coli chlN is moeB.; Similarity: similarity is from the central region of the predicted A. niger protein to chlN of E. coli, which is 250 aa shorter.; Title: similarity to molybdopterin-converting factor activator chlN - Escherichia coli; See PMID 11135669; See PMID 11463785; See PMID 8514782; uncharacterized protein 593847 4980290 An03g03000 Aspergillus niger uncharacterized protein XP_001390196.1 592201 D 5061 CDS An03g03010 4980291 join(594541..595045,595127..595617,595682..595909,596005..596095,596212..596313,596610..596752) VI 1 NT_166520.1 Remark: topoisomerase I from F. islandicum absolutely requires Mg2+ for activity, relaxes negatively but not positively supercoiled DNA and is inhibited by single-stranded M13 DNA and spermidine.; Title: similarity to hypothetical serine/threonine protein phosphatase topA - Fervidobacterium islandicum; See PMID 8241262; uncharacterized protein 596752 4980291 An03g03010 Aspergillus niger uncharacterized protein XP_059603576.1 594541 D 5061 CDS An03g03020 4980292 complement(598187..599236) VI 1 NT_166520.1 Remark: the impala element is 1280 nucleotides long and has inverted repeats of 27 bp.; Similarity: the translation of the impala ORF reveals strong similarities with the Tc1 from Caenorhabditis elegans and with the mariner element of Drosophila mauritiana.; Title: strong similarity to hypothetical impala transposase - Fusarium oxysporum; See PMID 7823909; uncharacterized protein 599236 4980292 An03g03020 Aspergillus niger uncharacterized protein XP_059603577.1 598187 R 5061 CDS An03g03030 4980293 complement(599832..604058) VI 1 NT_166520.1 Function: the KCL is part of the kinesin driven microtubule motor, walking towards the plus end and transporting vesicels.; Remark: the P. boryanum KLC represents a typical eukariotic protein in an eubacterial organism.; Title: strong similarity to cDNA kinesin light chain KLC - Plectonema boryanum; cytoplasm; See PMID 9212172; uncharacterized protein 604058 4980293 An03g03030 Aspergillus niger uncharacterized protein XP_001390199.1 599832 R 5061 CDS An03g03040 84590673 complement(<604542..605547) VI 1 NT_166520.1 Remark: possible sequencing errors occured at position 5058, 1 base has been removed and 5090, producing a STOP codon, which was also corrected.; Remark: the A. niger Ant1 shows similarity, at the amino acid level, to the transposase of the Tc1/mariner class of DNA transposons.; Similarity: similarity is on the aa level between the predicted A. niger protein and A. niger Ant1 orf1 but not to adjacent orf's of Ant1 and not on the DNA level.; Title: strong similarity to protein encoded by ORF1 of transposon Ant1 - Aspergillus niger [putative frameshift]; putative frameshift; See PMID 8552048; uncharacterized protein 605547 84590673 An03g03040 Aspergillus niger uncharacterized protein XP_059603578.1 604542 R 5061 CDS An03g03050 4980295 join(607004..608798,608982..609667) VI 1 NT_166520.1 Remark: the predicted M. musculus protein seems to be involved in the early foregut differentiation of the mouse.; Similarity: the predicted A. niger protein contains 10 ankyrin repeats (PF00023) distributed over the whole length of the protein.; Title: strong similarity to cDNA gene trap ankyrin repeat containing protein Gtar - Mus musculus; See PMID 11165478; uncharacterized protein 609667 4980295 An03g03050 Aspergillus niger uncharacterized protein XP_059603579.1 607004 D 5061 CDS An03g03060 84590674 complement(join(610890..611215,611328..611802)) VI 1 NT_166520.1 Remark: the ORF has an unusual exon/intron structure.; Similarity: the ORF shows strong similarity to another A. niger protein An12g06430. An12g06430 displays strong similarity to the reverse transcriptase of the LINE-like retrotransposon Tad1-1 of N. crassa.; Title: strong similarity to hypothetical protein encoded by An12g06430 - Aspergillus niger; uncharacterized protein 611802 84590674 An03g03060 Aspergillus niger uncharacterized protein XP_059603580.1 610890 R 5061 CDS An03g03070 4980297 complement(join(612252..613629,613701..614517,614575..615316,615545..616759)) VI 1 NT_166520.1 Function: MLP-2 of R. norvegicus might be a novel member of the MRP family responsible for the excretion of organic anions.; Induction: MLP-2 of R. norvegicus is markedly induced by ligation of the bile duct in SD rat liver.; Remark: MLP-2 of R. norvegicus has the characteristics of ATP-binding cassette transporters.; Remark: MLP-2 of R. norvegicus is also called ABCC3,CMOAT2, MRP3, or MLP.; Remark: MLP-2 of R. norvegicus was expressed predominantly in the duodenum, jejunum, and colon.; Title: strong similarity to multidrug resistance-associated protein (MRP)-like protein-2 MLP-2 -Rattus norvegicus; See PMID 9614210; See PMID 10581366; uncharacterized protein 616759 4980297 An03g03070 Aspergillus niger uncharacterized protein XP_059603581.1 612252 R 5061 CDS An03g03080 84590675 complement(join(618546..618811,618837..618915)) VI 1 NT_166520.1 hypothetical protein 618915 84590675 An03g03080 Aspergillus niger hypothetical protein XP_059603582.1 618546 R 5061 CDS An03g03090 84590676 join(619596..619617,619813..620777) VI 1 NT_166520.1 Remark: the ORF has an unusual exon/intron structure.; Title: strong similarity to hypothetical protein encoded by An04g07640 - Aspergillus niger; uncharacterized protein 620777 84590676 An03g03090 Aspergillus niger uncharacterized protein XP_059603583.1 619596 D 5061 CDS An03g03100 84590677 join(621721..622145,622386..622415,622652..622679) VI 1 NT_166520.1 Remark: the ORF has an unusual exon/intron structure.; Similarity: the ORF shows strong similarity to another A. niger protein An04g07840. An04g07840, however,is much longer than the ORF (518 compared to 160 amino acids).; Title: strong similarity to hypothetical protein encoded by An04g07840 - Aspergillus niger; uncharacterized protein 622679 84590677 An03g03100 Aspergillus niger uncharacterized protein XP_059603584.1 621721 D 5061 CDS An03g03110 84590678 complement(join(623331..625837,626042..626469,626635..627039,627189..627508,627635..627850)) VI 1 NT_166520.1 Remark: Tnt1 of N. tabacum is capable of transposition.; Similarity: the similarity between the ORF and Tnt1 of N. tabacum is restricted to the C-terminal part of the two proteins.; Title: strong similarity to retroviral-like transposable element Tnt1 - Nicotiana tabacum; See PMID 2536143; uncharacterized protein 627850 84590678 An03g03110 Aspergillus niger uncharacterized protein XP_059603585.1 623331 R 5061 CDS An03g03120 84590679 complement(join(628579..628704,628971..629036)) VI 1 NT_166520.1 Remark: the ORF is short in length (63 amino acids) and has an unusual exon/intron structure for A. niger.; Title: questionable ORF; uncharacterized protein 629036 84590679 An03g03120 Aspergillus niger uncharacterized protein XP_059603586.1 628579 R 5061 CDS An03g03130 4980303 629612..632059 VI 1 NT_166520.1 Function: pabaA of A. fumigatus is essential for pathogenicity.; Pathway: pabaA of A. fumigatus catalyes a late step in the biosynthesis of folate.; Title: strong similarity to para aminobenzoic acid synthase pabaA - Aspergillus fumigatus; See PMID 10931287; uncharacterized protein 632059 4980303 An03g03130 Aspergillus niger uncharacterized protein XP_059603587.1 629612 D 5061 CDS An03g03270 4980317 complement(join(663491..664239,664397..666421,666614..666767)) VI 1 NT_166520.1 Function: ankyrins link the spectrin-based membrane skeleton to the plasma membrane.; Remark: the mouse ankyrin seems aproximately 900 longer.; Title: similarity to ankyrin Ank1 - Mus musculus; See PMID 8486643; uncharacterized protein 666767 4980317 An03g03270 Aspergillus niger uncharacterized protein XP_001390210.3 663491 R 5061 CDS An03g03280 4980318 complement(join(668832..669518,669582..669821)) VI 1 NT_166520.1 Remark: Ant1 is apparently present as a single copy in strain N402 of A. niger.; Similarity: at the amino acid level, to the transposase of the Tc1/mariner class of DNA transposons.; Title: strong similarity to protein encoded by ORF1 of transposon Ant1 - Aspergillus niger; See PMID 8552048; uncharacterized protein 669821 4980318 An03g03280 Aspergillus niger uncharacterized protein XP_059600280.1 668832 R 5061 CDS An03g03290 4980319 join(671239..671776,671881..672214,672267..672324) VI 1 NT_166520.1 Remark: This sequence may be useful for protein identification and for aiding in the elucidation of signal transduction and metabolic pathways.; Remark: strong similarity to Arabidopsis thaliana protein fragment SEQ ID NO: 12343 patent EP1033405-A2.; Title: similarity to protein fragment SEQ ID NO:12343 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 672324 4980319 An03g03290 Aspergillus niger uncharacterized protein XP_001390212.1 671239 D 5061 CDS An03g03300 4980320 join(673726..673909,673971..675442) VI 1 NT_166520.1 Function: The N-glycosidase of P. dulcis acts by hydrolysing a beta-aspartyl glycosylamin bond of an asparagine-linkage type sugar chain of a glycopeptide.; Remark: the ORF encoded protein is almost identical to a peptide-N4-(N-acetyl-beta-D-glucosaminyl) asparaginase amidase N (pngN) of A. tubigensis which is wrongly assigned to A. niger (compare TREMBL:U96923_1 with PUBMED-ID: 9312552).; Title: similarity to almond N-glycosidase from patent EP676473-A2 - Prunus dulcis; uncharacterized protein 675442 4980320 An03g03300 Aspergillus niger uncharacterized protein XP_001390213.1 673726 D 5061 CDS An03g03310 4980321 complement(join(677396..678107,678158..678902,678962..679085,679140..679259,679346..679374,679413..679445,679484..679516,679628..679654,679918..679950,680058..680079,680196..680237,680319..680366)) VI 1 NT_166520.1 Function: in N. crassa the tol protein is required for growth inhibition and cell death that occur when hyphae of opposite mating type fuse during vegetative growth.; Phenotype: point mutations in tol result in mutants that are wild type during vegetative growth and sexual reproduction, but that allow opposite mating-type individuals to form a vigorous heterokaryon.; Title: similarity to protein tol - Neurospora crassa; See PMID 9927450; uncharacterized protein 680366 4980321 An03g03310 Aspergillus niger uncharacterized protein XP_059600281.1 677396 R 5061 CDS An03g03320 84590680 <682024..682134 VI 1 NT_166520.1 Remark: the ORF encoded protein is N-terminally truncated due to the contig border.; Remark: the blastp matches are unspecific.; hypothetical protein [truncated ORF] 682134 84590680 An03g03320 Aspergillus niger hypothetical protein [truncated ORF] XP_059605187.1 682024 D 5061 CDS An03g03330 4980323 complement(join(683201..684163,684231..684524,684582..685235)) VI 1 NT_166520.1 Catalytic activity: phenol 2-monooxygenase of T. beigelii catalyzes the reaction of Phenol + NADPH + O(2) <=> catechol + NADP(+) + H(2)O.; Title: similarity to phenol 2-monooxygenase -Trichosporon beigelii; See PMID 1429434; uncharacterized protein 685235 4980323 An03g03330 Aspergillus niger uncharacterized protein XP_001390216.1 683201 R 5061 CDS An03g03340 4980324 complement(686112..687263) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein encoded by An01g11840 - Aspergillus niger; uncharacterized protein 687263 4980324 An03g03340 Aspergillus niger uncharacterized protein XP_001390217.3 686112 R 5061 CDS An03g03350 4980325 complement(join(687673..687869,687916..687955,688307..688318,688375..688462,688729..688881,689204..689225,689292..689413,689473..690273,690333..690407,690468..691328,691388..691500,691558..691716)) VI 1 NT_166520.1 Remark: HAP1 of S. cerevisiae has a systematic name of YLR256W.; Remark: HAP1 of S. cerevisiae was originally called CYP1 but this has now been assigned to a different gene.; Remark: the blastp matches of the ORF encoded protein is restricted to the fungal Zn(2)-Cys(6) binuclear cluster domain.; Similarity: the ORF encoded protein shows similarity to several fungal transcription factors.; Title: weak similarity to transcription activator Hap1 - Saccharomyces cerevisiae; nucleus; uncharacterized protein 691716 4980325 An03g03350 Aspergillus niger uncharacterized protein XP_059605188.1 687673 R 5061 CDS An03g03360 4980326 join(693613..693861,693910..693958,694016..694032,694092..694705,694762..694810) VI 1 NT_166520.1 Function: the A. nidulans acuH gene is required for growth on acetate and long-chain fatty acids.; Function: the proposed function of the ACUH protein is the transport of acetylcarnitine molecules from the cytosol to the mitochondrial matrix.; Similarity: the A. nidulans acuH gene belongs to the mitochondrial carrier family.; Title: strong similarity to carnitine/acyl carnitine carrier acuH - Aspergillus nidulans; uncharacterized protein 694810 4980326 An03g03360 Aspergillus niger uncharacterized protein XP_001390219.1 693613 D 5061 CDS An03g03370 84590681 join(695438..696521,696552..697788,698579..698945) VI 1 NT_166520.1 Similarity: the ORF shows strong similarity to the A. niger protein An03g03030. An03g03030, however, is much longer than the ORF.; Title: similarity to hypothetical protein CAD21095.1 - Neurospora crassa; uncharacterized protein 698945 84590681 An03g03370 Aspergillus niger uncharacterized protein XP_059605189.1 695438 D 5061 CDS An03g03380 84590682 join(699145..699488,699724..700036) VI 1 NT_166520.1 hypothetical protein 700036 84590682 An03g03380 Aspergillus niger hypothetical protein XP_059605190.1 699145 D 5061 CDS An03g03390 4980329 complement(join(701225..701582,701639..702144,702218..702646)) VI 1 NT_166520.1 Similarity: the ORF is nearly identical to another A. niger protein: An09g01480.; Title: strong similarity to hypothetical protein encoded by An09g01480 - Aspergillus niger; uncharacterized protein 702646 4980329 An03g03390 Aspergillus niger uncharacterized protein XP_001390222.1 701225 R 5061 CDS An03g03400 84590683 join(704096..704426,704490..704977) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein encoded by An09g01460 - Aspergillus niger; uncharacterized protein 704977 84590683 An03g03400 Aspergillus niger uncharacterized protein XP_059605191.1 704096 D 5061 CDS An03g03420 4980332 706201..707040 VI 1 NT_166520.1 Similarity: the ORF encoded protein also shows similarity to hypothetical and known beta-lactamases (EC 3. 5. 2. 6) of different organisms.; Title: strong similarity to hypothetical protein PA0057 - Pseudomonas aeruginosa; uncharacterized protein 707040 4980332 An03g03420 Aspergillus niger uncharacterized protein XP_001390224.1 706201 D 5061 CDS An03g03430 84590684 join(710412..710750,710867..710923,711232..711271,711326..711396) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein encoded by An01g15030 - Aspergillus niger; uncharacterized protein 711396 84590684 An03g03430 Aspergillus niger uncharacterized protein XP_059605192.1 710412 D 5061 CDS An03g03440 84590685 join(713548..713672,713707..713932) VI 1 NT_166520.1 Title: similarity to hypothetical protein encoded by An09g00290 - Aspergillus niger; uncharacterized protein 713932 84590685 An03g03440 Aspergillus niger uncharacterized protein XP_059605193.1 713548 D 5061 CDS An03g03450 4980335 complement(join(715153..715552,715616..715809,715895..716043,716226..716243,716544..716718)) VI 1 NT_166520.1 Similarity: the ORF encoded protein also shows similarity to several hypothetical and known oxidoreductases.; Title: strong similarity to hypothetical alginate lyase BH0738 - Bacillus halodurans; uncharacterized protein 716718 4980335 An03g03450 Aspergillus niger uncharacterized protein XP_059605194.1 715153 R 5061 CDS An03g03460 4980336 complement(717073..718815) VI 1 NT_166520.1 Catalytic activity: D-arabinono-1,4-lactone oxidase catalyzes the reaction of D-arabinono-1,4-lactone + O(2) <=> D-erythro-ascorbate + H(2)O(2).; Catalytic activity: L-galactonolactone oxidase (1. 1. 3. 24) catalyzes the reaction of L-galactono-1,4-lactone + O(2) <=> L-ascorbate + H(2)O(2).; Function: D-erythroascorbic acid is an important antioxidant molecule in S. cerevisiae.; Remark: D-arabinono-1,4-lactone oxidase (1. 1. 3. 27) and protein YML086c are alternative names for L-galactonolactone oxidase in S. cerevisiae.; Title: strong similarity to L-galactonolactone oxidase Alo - Saccharomyces cerevisiae; See PMID 10094636; uncharacterized protein 718815 4980336 An03g03460 Aspergillus niger uncharacterized protein XP_001390228.1 717073 R 5061 CDS An03g03470 4980337 complement(join(721282..723500,723612..723624)) VI 1 NT_166520.1 Function: the phrA gene plays a role in the genetic control of photoreactivation in Escherichia coli.; Function: the phrA gene product acts on lesions other than dimers, possibly pyrimidine (6-4) pyrimidone photoproducts.; Remark: the ORF encoded protein also shows similarity to hypothetical ABC transporter, ATP-binding proteins of different species.; Title: similarity to deoxyribodipyrimidine photolyase phrA - Escherichia coli; See PMID 7791009; uncharacterized protein 723624 4980337 An03g03470 Aspergillus niger uncharacterized protein XP_001390229.3 721282 R 5061 CDS An03g03480 4980338 join(724685..724895,724952..725087,725160..725271,725320..725457,725503..726417,726735..726879,726946..727171,727207..727264) VI 1 NT_166520.1 Catalytic activity: UGDH catalyzes the reaction of UDP-glucose + 2 NAD(+) + H(2)O <=> UDP-glucuronate + 2 NADH.; Function: human UGDH is a critical component of the glycosaminoglycans, hyaluronan, chondroitin sulfate, and heparan sulfate.; Title: similarity to UDP-glucose dehydrogenase UGDH - Homo sapiens; See PMID 9737970; uncharacterized protein 727264 4980338 An03g03480 Aspergillus niger uncharacterized protein XP_059605195.1 724685 D 5061 CDS An03g03490 4980339 complement(728057..729160) VI 1 NT_166520.1 hypothetical protein 729160 4980339 An03g03490 Aspergillus niger hypothetical protein XP_001390231.1 728057 R 5061 CDS An03g03500 4980340 729809..731266 VI 1 NT_166520.1 Title: strong similarity to hypothetical protein CAD36989.1 - Neurospora crassa; uncharacterized protein 731266 4980340 An03g03500 Aspergillus niger uncharacterized protein XP_059605196.1 729809 D 5061 CDS An03g03510 4980341 732198..733577 VI 1 NT_166520.1 Title: similarity to hypothetical protein encoded by An15g01720 - Aspergillus niger; uncharacterized protein 733577 4980341 An03g03510 Aspergillus niger uncharacterized protein XP_001390233.1 732198 D 5061 CDS An03g03520 4980342 complement(join(735328..741123,741195..741668,741796..741867)) VI 1 NT_166520.1 Function: AM-toxin of A. alternata is a cyclic peptide host-specific toxin.; Phenotype: disruption of AM-toxin synthetase (AMT) resulted in toxin-minus mutants.; Similarity: AM-toxin synthetase of A. alternaty shows strong similarity to other fungal peptide synthetases.; Title: similarity to cyclic peptide AM-toxin synthase AMT - Alternaria alternata; See PMID 10875335; uncharacterized protein 741867 4980342 An03g03520 Aspergillus niger uncharacterized protein XP_001390234.3 735328 R 5061 CDS An03g03530 4980343 join(743775..743828,743896..744939) VI 1 NT_166520.1 Similarity: the ORF shows strong similarity to the A. niger protein An16g04320.; Title: similarity to protein fragment SEQ ID NO:9681 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 744939 4980343 An03g03530 Aspergillus niger uncharacterized protein XP_001390235.1 743775 D 5061 CDS An03g03540 4980344 complement(join(745783..746154,746294..747262)) VI 1 NT_166520.1 Function: iucB of E. coli functions as N epsilon-hydroxylysine:acetyl coenzyme A N epsilon-transacetylase.; Pathway: iucB of E. coli is involved in the aerobactin biosynthesis.; Title: similarity to aerobactin biosynthesis protein iucB - Escherichia coli; See PMID 8003107; See PMID 2935523; uncharacterized protein 747262 4980344 An03g03540 Aspergillus niger uncharacterized protein XP_001390236.1 745783 R 5061 CDS An03g03550 4980345 join(747635..747863,747935..748524) VI 1 NT_166520.1 Catalytic activity: caiD of E. coli catalizes the reaction of D-carnitine to L-carnitine.; Pathway: carnitine metabolism.; Similarity: caiD of E. coli belongs to the enoyl-CoA hydratase/isomerase family.; Similarity: the ORF encoded protein also shows strong similarity to hypothetical and know enoyl-CoA hydratases (EC 4. 2. 1. 17).; Title: strong similarity to carnitine racemase caiD - Escherichia coli; See PMID 9748275; uncharacterized protein 748524 4980345 An03g03550 Aspergillus niger uncharacterized protein XP_001390237.1 747635 D 5061 CDS An03g03560 4980346 join(749786..750045,750116..750386,750451..750787,750845..751776) VI 1 NT_166520.1 Function: ARN1, is involved in the transport of a specific class of ferrichromes, possessing anhydromevalonyl residues linked to N(delta)-ornithine (ARN).; Remark: YHL040C is the systematic name for ARN1.; Title: strong similarity to ferrichrome-type siderophore transporter Arn1 - Saccharomyces cerevisiae; See PMID 10802175; uncharacterized protein 751776 4980346 An03g03560 Aspergillus niger uncharacterized protein XP_001390238.1 749786 D 5061 CDS An03g03570 4980347 complement(join(753005..753399,753488..753926,754077..754784)) VI 1 NT_166520.1 Remark: the ORF encoded protein also shows weak similarity to a human prenylcysteine carboxyl methyltransferase (by similarity) from patent W67730.; Title: weak similarity to hypothetical farnesyl cysteine carboxyl methyltransferase - Brucella melitensis; uncharacterized protein 754784 4980347 An03g03570 Aspergillus niger uncharacterized protein XP_001390239.3 753005 R 5061 CDS An03g03580 4980348 join(755273..755844,755881..755974) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein 65E11.100 - Neurospora crassa; uncharacterized protein 755974 4980348 An03g03580 Aspergillus niger uncharacterized protein XP_059605197.1 755273 D 5061 CDS An03g03590 4980349 complement(join(756860..757936,758084..758581)) VI 1 NT_166520.1 Function: SPT10 of S. cerevisiae affects transcription at Ty1 elements, at PHO5,STE6 and ADH2.; Function: SPT10 of S. cerevisiae is a global transcriptional repressor of core promoter activity.; Function: SPT10 of S. cerevisiae is equired for normal levels of transcription and increased transcriptional regulation at a number of loci.; Remark: CRE1, SUD1 and YJL127C are alternative names for SPT10.; Title: strong similarity to regulator protein Spt10 - Saccharomyces cerevisiae; nucleus; See PMID 8138180; See PMID 8264536; uncharacterized protein 758581 4980349 An03g03590 Aspergillus niger uncharacterized protein XP_001390241.1 756860 R 5061 CDS An03g03600 4980350 759467..761506 VI 1 NT_166520.1 Title: strong similarity to hypothetical DEAD box family helicase - Schizosaccharomyces pombe; uncharacterized protein 761506 4980350 An03g03600 Aspergillus niger uncharacterized protein XP_001390242.1 759467 D 5061 CDS An03g03610 84590686 complement(join(764085..764146,764234..764268,764334..764383)) VI 1 NT_166520.1 hypothetical protein 764383 84590686 An03g03610 Aspergillus niger hypothetical protein XP_059605198.1 764085 R 5061 CDS An03g03620 4980352 complement(join(764922..767932,767990..768923)) VI 1 NT_166520.1 Function: atrDp is involved in protection against cytotoxic compounds.; Title: strong similarity to multidrug resistance protein atrD - Aspergillus nidulans; plasma membrane; See PMID 10954082; uncharacterized protein 768923 4980352 An03g03620 Aspergillus niger uncharacterized protein XP_001390244.1 764922 R 5061 CDS An03g03640 4980353 join(774001..774044,774441..774493,774720..776206) VI 1 NT_166520.1 Catalytic activity: enzyme of S. pombe catalyzes the reduction of quinone (coenzyme Q2) by sulfide.; Remark: questionable geneprediction at the aminoterminus might be caused by sequencing error.; Remark: the predicted protein is too long.; Title: strong similarity to mitochondrial sulfide dehydrogenase (coenzyme Q2) SPBC2G5.06c -Schizosaccharomyces pombe; localisation:mitochondrion; uncharacterized protein 776206 4980353 An03g03640 Aspergillus niger uncharacterized protein XP_059605199.1 774001 D 5061 CDS An03g03650 84590687 complement(join(776448..776734,776825..776956,777142..777721)) VI 1 NT_166520.1 Similarity: shows only partial similarity to hypothetical protein.; Title: weak similarity to hypothetical protein YJR111c - Saccharomyces cerevisiae; uncharacterized protein 777721 84590687 An03g03650 Aspergillus niger uncharacterized protein XP_059605200.1 776448 R 5061 CDS An03g03660 4980355 complement(join(778492..778925,778998..779830,779909..780060)) VI 1 NT_166520.1 Catalytic activity: converts oxidized glutathionine + NADPH into 2 glutathionine + NADP.; Function: enzyme of S. cerevisiae functions to maintain reduced glutathione levels at high levels.; Similarity: show strong similarity to other glutathione reductases.; Title: strong similarity to glutathione reductase Glr1 - Saccharomyces cerevisiae; uncharacterized protein 780060 4980355 An03g03660 Aspergillus niger uncharacterized protein XP_001390247.3 778492 R 5061 CDS An03g03670 4980356 complement(join(781002..781039,781072..781867,781937..782631,782730..782810,782908..782995)) VI 1 NT_166520.1 hypothetical protein 782995 4980356 An03g03670 Aspergillus niger hypothetical protein XP_001390248.3 781002 R 5061 CDS An03g03680 84590688 join(784484..784702,784780..785125,785221..785579) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein encoded by An13g03400 - Aspergillus niger; uncharacterized protein 785579 84590688 An03g03680 Aspergillus niger uncharacterized protein XP_059605201.1 784484 D 5061 CDS An03g03690 84590689 complement(join(786376..786500,786595..786676,786740..786943)) VI 1 NT_166520.1 Similarity: the ORF shows similarity to another A. niger protein: An03g03680. However, the two proteins differ in length and the similarity between the two proteins is restricted to a stretch of about 70 amino acids.; Title: weak similarity to hypothetical protein encoded by An03g03680 - Aspergillus niger; uncharacterized protein 786943 84590689 An03g03690 Aspergillus niger uncharacterized protein XP_059605202.1 786376 R 5061 CDS An03g03700 4980359 join(789200..789380,789446..789497,789565..789653,789722..790160,790230..790361,790418..790526) VI 1 NT_166520.1 Function: the function of the qutG and some other proteins of this family is not yet clear, but it is suggested that they may act by enhancing the synthesis or degradation of phosphorylated messenger molecules.; Similarity: belongs to inositol monophosphatase family.; Title: strong similarity to inositol monophosphatase qutG - Aspergillus nidulans; See PMID 2175387; uncharacterized protein 790526 4980359 An03g03700 Aspergillus niger uncharacterized protein XP_001390251.1 789200 D 5061 CDS An03g03710 4980360 complement(790835..791869) VI 1 NT_166520.1 Function: both the shikimate and quinate pathways share two common pathway metabolites 3-dehydroquinate and dehydroshikimate.; Function: quinate 5-dehydrogenase catalyses the conversion of quinate to 5-dehydroquinate.; Function: the functional integrity of the QUTB gene from A. nidulans (encoding quinate dehydrogenase) has been confirmed by transformation of a qutB mutant strain.; Function: this reaction is part of the quinate pathway where quinic acid is exploited as a source of carbon in prokaryotes and microbial eukaryotes.; Similarity: belongs to the shikimate and quinate dehydrogenases family.; Title: strong similarity to quinate 5-dehydrogenase qutB - Aspergillus nidulans; See PMID 2976880; uncharacterized protein 791869 4980360 An03g03710 Aspergillus niger uncharacterized protein XP_001390252.1 790835 R 5061 CDS An03g03720 4980361 join(793192..793293,793350..793944,794018..794433) VI 1 NT_166520.1 Function: RAD14 plays an early role in nucleotide excision repair by recognizing and binding to damaged DNA.; Function: it binds specifically to damaged DNA.; Function: it is not required for transcription (although it contains zinc finger domains).; Function: it recognizes pyrimidine(6-4)pyrimidone photoproducts.; Title: strong similarity to nucleotide excision repair protein Rad14 - Saccharomyces cerevisiae; nucleus; See PMID 9268290; uncharacterized protein 794433 4980361 An03g03720 Aspergillus niger uncharacterized protein XP_001390253.1 793192 D 5061 CDS An03g03730 4980362 complement(795308..796114) VI 1 NT_166520.1 Catalytic activity: H2CO3 = CO2 + H2O; Function: carbonic anhydrases are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide.; Similarity: shows strong similarity to putative carbonic anhydrases of several organisms.; Title: strong similarity to hypothetical carbonic anhydrase SPBP8B7.05c - Schizosaccharomyces pombe; uncharacterized protein 796114 4980362 An03g03730 Aspergillus niger uncharacterized protein XP_001390254.3 795308 R 5061 CDS An03g03740 4980363 complement(join(797429..797567,797632..798217,798298..798770,798828..799019,799100..799161)) VI 1 NT_166520.1 Function: O-Glycosyl hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety.; Function: beta-glucosidases of H. grisea and T. reesei are involved in cellulose utilization.; Localization: enzymes might be secreted.; Similarity: these fungal beta-glucosidases show significant homology to plant beta-glucosidases belonging to the beta-glucosidase A (BGA) family.; Title: strong similarity to beta-glucosidase bgl4 -Humicola grisea; See PMID 10101286; uncharacterized protein 799161 4980363 An03g03740 Aspergillus niger uncharacterized protein XP_001390255.1 797429 R 5061 CDS An03g03750 4980364 join(802151..802400,802481..802955,803010..804129) VI 1 NT_166520.1 Function: abr2 is involved in conidial pigment biosynthesis in A. fumigatus.; Function: the enzymes that belong to this family include laccase that in fungi and plants oxidizes many different types of phenols and diamines, ascorbate oxidase.; Similarity: belongs to the multicopper oxidase family and shows strong similarity to laccases.; Title: strong similarity to brown 2 protein abr2 -Aspergillus fumigatus; See PMID 10515939; uncharacterized protein 804129 4980364 An03g03750 Aspergillus niger uncharacterized protein XP_001390256.1 802151 D 5061 CDS An03g03760 4980365 complement(join(806643..808131,808228..808406)) VI 1 NT_166520.1 Similarity: blast hits contain a lot of repetitive sequences.; Similarity: the expression of a single neurofilament subunit in the lamprey that is most similar to the NF-M of higher vertebrates suggests that all three mammalian neurofilament subunits evolved from a single NF-M-like precursor.; Title: weak similarity to neurofilament subunit NF-180 - Petromyzon marinus; See PMID 7770000; uncharacterized protein 808406 4980365 An03g03760 Aspergillus niger uncharacterized protein XP_001390257.1 806643 R 5061 CDS An03g03770 4980366 join(809457..810726,810805..811073) VI 1 NT_166520.1 Alternative name: usually ERG1.; Cofactor: squalene epoxidase contain a FAD binding domain.; Function: squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway.; Similarity: squalene epoxidases seem to be highly variable at the aminoterminus because there exist several shorter and longer variants.; Title: strong similarity to squalene monooxygenase -Rattus norvegicus; endoplasmatic reticulum; uncharacterized protein 811073 4980366 An03g03770 Aspergillus niger uncharacterized protein XP_001390258.1 809457 D 5061 CDS An03g03780 4980367 complement(join(812973..815386,815455..815673,815736..815807,815870..816395)) VI 1 NT_166520.1 Function: probably contains a nucleotidyltransferase domain and shows similarity to proteins containing such domains (ie. nuclear division protein TRF5 with DNA topoisomerase I-related function from S. cerevisiae).; Similarity: shows strong similarity at the aminoterminal part to several hypothetical proteins but is in general much longer.; Title: similarity to hypothetical protein SPAC821.04c - Schizosaccharomyces pombe; uncharacterized protein 816395 4980367 An03g03780 Aspergillus niger uncharacterized protein XP_001390259.1 812973 R 5061 CDS An03g03790 84590690 complement(join(819483..819554,819662..819901,819986..820144,820331..820407,820449..820674,820754..820900,821383..821592)) VI 1 NT_166520.1 hypothetical protein 821592 84590690 An03g03790 Aspergillus niger hypothetical protein XP_059605203.1 819483 R 5061 CDS An03g03800 4980369 join(824051..824135,824208..824264,824420..824524,824583..824801,824970..825754) VI 1 NT_166520.1 Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: a splice site was detected upstream of the START codon.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: weak similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942; uncharacterized protein 825754 4980369 An03g03800 Aspergillus niger uncharacterized protein XP_001390261.1 824051 D 5061 CDS An03g03810 4980370 complement(826594..827544) VI 1 NT_166520.1 Title: strong similarity to hypothetical conserved protein XF1745 - Xylella fastidiosa; uncharacterized protein 827544 4980370 An03g03810 Aspergillus niger uncharacterized protein XP_001390262.1 826594 R 5061 CDS An03g03820 4980371 complement(join(828225..829096,829171..829361,829427..829644)) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein SPCC320.08 - Schizosaccharomyces pombe; uncharacterized protein 829644 4980371 An03g03820 Aspergillus niger uncharacterized protein XP_001390263.1 828225 R 5061 CDS An03g03830 4980372 join(833172..833285,833423..833519,833610..833691,833762..833811,833889..834215,834266..835066,835131..835298,835363..836453) VI 1 NT_166520.1 Similarity: most fungal proteins with similarities to the predicted protein are much shorter.; Similarity: shows similarity in the central part to Drosophila protein and several other hypothetical proteins.; Title: similarity to hypothetical protein CG9351 -Drosophila melanogaster; uncharacterized protein 836453 4980372 An03g03830 Aspergillus niger uncharacterized protein XP_059605204.1 833172 D 5061 CDS An03g03840 4980373 join(837312..837399,837434..838014,838092..838276,838365..838666,838765..838826) VI 1 NT_166520.1 Title: similarity to hypothetical membrane protein YPR147c - Saccharomyces cerevisiae; uncharacterized protein 838826 4980373 An03g03840 Aspergillus niger uncharacterized protein XP_059605205.1 837312 D 5061 CDS An03g03850 4980374 complement(839019..840035) VI 1 NT_166520.1 Title: similarity to hypothetical protein encoded by G15G9.130 - Neurospora crassa; uncharacterized protein 840035 4980374 An03g03850 Aspergillus niger uncharacterized protein XP_001390266.3 839019 R 5061 CDS An03g03860 4980375 join(840727..841597,841751..841988,842193..843900) VI 1 NT_166520.1 Catalytic activity: Inositol-1,4,5-trisphosphate 5-phosphatases convert D-myo-inositol 1,4,5-trisphosphate + H(2)O <=> D-myo-inositol 1,4-bisphosphate + phosphate.; Function: mouse INPP5P hydrolyzes various signaling molecules including the following: inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate,phosphatidylinositol 4,5-bisphosphate, and phosphatidylinositol 3,4, 5-trisphosphate.; Localization: expression of the 115-kDa protein of M. musculus showed localization of enzyme activity to the membrane.; Localization: in mouse at least three isoforms of INPP5P derived from RNA splicing events exist, this allows differential distribution of the INPP5P activity between the membrane and cytosol of the cell.; Title: similarity to Inositol-1,4,5-trisphosphate 5-phosphatases INPP5P - Mus musculus; See PMID 9525932; uncharacterized protein 843900 4980375 An03g03860 Aspergillus niger uncharacterized protein XP_059605206.1 840727 D 5061 CDS An03g03870 4980376 complement(844556..845239) VI 1 NT_166520.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons.; Title: questionable ORF; uncharacterized protein 845239 4980376 An03g03870 Aspergillus niger uncharacterized protein XP_001390268.3 844556 R 5061 CDS An03g03880 84590691 join(846087..846163,846239..846330,846406..846500,846592..846686,846827..846900,846987..847249) VI 1 NT_166520.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons.; Similarity: shows weak similarity to part of pilin from N. gonorrhoeae and immunoglobulin kappa-chain from H. sapiens.; Title: questionable ORF; uncharacterized protein 847249 84590691 An03g03880 Aspergillus niger uncharacterized protein XP_059605207.1 846087 D 5061 CDS An03g03890 4980378 join(847717..848278,848339..848822,848875..849166,849577..849635,849725..849899) VI 1 NT_166520.1 Function: S. cerevisiae STE3 is a G protein-coupled receptor for the peptide pheromone a-factor.; Regulation: S. cerevisiae STE3 is endocytosed and recycled upon a-factor binding.; Regulation: in S. cerevisiae a-factor-induced phosphorylation of STE3 requires activation of the downstream G protein-directed signaling pathway.; Remark: alternative names for S. cerevisiae STE3 are DAF2 and YKL178c.; Title: similarity to peptide pheromone a-factor receptor Ste3 - Saccharomyces cerevisiae; plasma membrane; See PMID 10611235; See PMID 11062272; See PMID 3006051; uncharacterized protein 849899 4980378 An03g03890 Aspergillus niger uncharacterized protein XP_059605208.1 847717 D 5061 CDS An03g03900 4980379 complement(join(850024..850091,850197..850285,850438..850727)) VI 1 NT_166520.1 Function: S. cerevisiae RIM1 is a nuclear gene encoding a mitochondrial single-stranded DNA-binding protein (SSB), which is required for activity of mitochondrial DNA-polymerase.; Remark: the predicted A. niger protein shows a pfam domain specific for single-stranded DNA-binding proteins.; Similarity: S. cerevisiae RIM1 contains three regions similar to C2H2 zinc fingers and an active cAMP-dependent protein kinase (cAPK) phosphorylation site.; Similarity: the predicted A. niger protein shows similarity to single-stranded DNA-binding proteins (including hypothetical) of different species.; Title: similarity to single-stranded DNA-binding protein Rim1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8367297; See PMID 9871116; See PMID 11087374; uncharacterized protein 850727 4980379 An03g03900 Aspergillus niger uncharacterized protein XP_001390271.1 850024 R 5061 CDS An03g03910 84590692 complement(join(850907..851006,851140..851219)) VI 1 NT_166520.1 Remark: ORF might be questionable due to wrong gene prediction.; Title: weak similarity to creatinine amidohydrolase PSPS7 - Pseudomonas sp.; See PMID 7670196; uncharacterized protein 851219 84590692 An03g03910 Aspergillus niger uncharacterized protein XP_059605209.1 850907 R 5061 CDS An03g03920 84590693 complement(852016..852444) VI 1 NT_166520.1 Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 852444 84590693 An03g03920 Aspergillus niger uncharacterized protein XP_059605210.1 852016 R 5061 CDS An03g03930 4980382 join(852969..853228,853320..853430,853485..853533,853637..853976,854115..856510) VI 1 NT_166520.1 Function: contains a Sodium:galactoside symporter pfam-domain.; Similarity: shows similarity between central regions of the predicted A. niger protein and several neurofilaments (NF), this similarity might results a great deal from repetitive sequences.; Title: weak similarity to neurofilament NF-180 -Petromyzon marinus; See PMID 7770000; uncharacterized protein 856510 4980382 An03g03930 Aspergillus niger uncharacterized protein XP_059605211.1 852969 D 5061 CDS An03g03940 4980383 complement(join(857324..857922,858030..859400,859547..860477,860565..860744,860818..861348)) VI 1 NT_166520.1 Function: S. cerevisiae SAC3 is involved in leucine permease transcriptional regulation, actin cytoskeleton organisation and mitosis.; Similarity: similarity is between the N-terminal regions of the predicted A. niger protein and Sac3 of S. cerevisiae.; Title: similarity to potential regulator of leucine permease gene expression Sac3 - Saccharomyces cerevisiae; nucleus; See PMID 8799844; See PMID 10517330; uncharacterized protein 861348 4980383 An03g03940 Aspergillus niger uncharacterized protein XP_059605212.1 857324 R 5061 CDS An03g03950 84590694 join(861587..861631,861721..861804,861879..862013) VI 1 NT_166520.1 hypothetical protein 862013 84590694 An03g03950 Aspergillus niger hypothetical protein XP_059605213.1 861587 D 5061 CDS An03g03960 4980385 complement(join(862048..862167,862317..862393,862495..862530,862909..863617,863702..864324,864382..864586,864640..864732)) VI 1 NT_166520.1 Similarity: N-terminal region of predicted A. niger protein shows also similarity to N-terminal region of the hypothetical protein YDR124w from S. cerevisiae, which is 300 aa shorter.; Similarity: the ORF shows strong similarity to the A. niger protein An02g11860. The similarity between the two proteins, however, is restricted to a stretch of about 150 amino acids.; Title: strong similarity to hypothetical protein EAA61242.1 - Aspergillus nidulans; uncharacterized protein 864732 4980385 An03g03960 Aspergillus niger uncharacterized protein XP_059605214.1 862048 R 5061 CDS An03g03970 84590695 join(864802..864835,864918..865018,865109..865165,865258..865371,865575..865685) VI 1 NT_166520.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons.; Title: questionable ORF; uncharacterized protein 865685 84590695 An03g03970 Aspergillus niger uncharacterized protein XP_059605215.1 864802 D 5061 CDS An03g03980 84590696 complement(join(866273..866353,866433..866582)) VI 1 NT_166520.1 Remark: blastp shows significant similarity (39% identity) between predicted A. niger protein and human secreted protein of patent WO9922243 but due to shortness of both peptides the probability is low (p=4,4).; Title: similarity to secreted protein from patent WO9922243 - Homo sapiens; uncharacterized protein 866582 84590696 An03g03980 Aspergillus niger uncharacterized protein XP_059605216.1 866273 R 5061 CDS An03g03990 84590697 join(867086..867223,867416..867490,867580..867725,867817..867931,868058..868147,868342..868602) VI 1 NT_166520.1 Similarity: shows weak but significant similarity to part of the 5-aminolevulinate synthase of different species.; Title: weak similarity to 5-aminolevulinate synthase ALASN - Gallus gallus; See PMID 3005973; uncharacterized protein 868602 84590697 An03g03990 Aspergillus niger uncharacterized protein XP_059605217.1 867086 D 5061 CDS An03g04000 84590698 join(869943..870023,870130..870189,870298..870549) VI 1 NT_166520.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons.; Title: questionable ORF; uncharacterized protein 870549 84590698 An03g04000 Aspergillus niger uncharacterized protein XP_059605218.1 869943 D 5061 CDS An03g04010 84590699 join(870766..870780,870912..871165,871209..871268,871406..871488,871823..871924,872306..872344,872623..872786) VI 1 NT_166520.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons.; Title: questionable ORF; uncharacterized protein 872786 84590699 An03g04010 Aspergillus niger uncharacterized protein XP_059605219.1 870766 D 5061 CDS An03g04020 84590700 complement(join(873104..873200,873511..873581,873675..873815,873900..873959,874052..874110,874396..874494,874787..874939,875032..875131,875227..875281,875383..875480)) VI 1 NT_166520.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons.; Title: questionable ORF; uncharacterized protein 875480 84590700 An03g04020 Aspergillus niger uncharacterized protein XP_059605220.1 873104 R 5061 CDS An03g04030 84590701 complement(join(875577..875646,875748..875834,876049..876126,876213..876430,876596..876673)) VI 1 NT_166520.1 Remark: blastp shows similarity (43% positives) between predicted A. niger protein and A. thaliana T6K12. 13 but due to shortness of both peptides the probability is low (p=6,4).; Similarity: similarity is from predicted A. niger protein to C-terminal region of A. .; Title: similarity to hypothetical protein T6K12.13 -Arabidopsis thaliana; uncharacterized protein 876673 84590701 An03g04030 Aspergillus niger uncharacterized protein XP_059605221.1 875577 R 5061 CDS An03g04040 84590702 complement(join(877150..877248,877665..877757,877855..878082,878198..878332)) VI 1 NT_166520.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons.; Title: questionable ORF; uncharacterized protein 878332 84590702 An03g04040 Aspergillus niger uncharacterized protein XP_059605222.1 877150 R 5061 CDS An03g04050 84590703 complement(join(878553..878678,878753..878829,879177..879329,879417..879461,879804..879849)) VI 1 NT_166520.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons.; Title: questionable ORF; uncharacterized protein 879849 84590703 An03g04050 Aspergillus niger uncharacterized protein XP_059605223.1 878553 R 5061 CDS An03g04060 4980395 complement(join(882027..882290,882383..882474,882567..882635,882698..882852,882920..883704,883758..883803,883871..883974,884036..886852,886925..887218)) VI 1 NT_166520.1 Function: ATP binding cassette (ABC) protein superfamily members transport a variety of substances across biological membranes, including drugs, ions and peptides.; Function: the cadmium factor (YCF1) gene from S. cerevisiae is required for cadmium resistance.; Similarity: belongs to the ATP binding cassette (ABC) protein superfamily.; Title: strong similarity to cadmium resistance protein Ycf1 - Saccharomyces cerevisiae; See PMID 7521334; See PMID 9379898; See PMID 10529352; uncharacterized protein 887218 4980395 An03g04060 Aspergillus niger uncharacterized protein XP_001390287.1 882027 R 5061 CDS An03g04070 84590704 complement(join(888242..888358,888399..888470)) VI 1 NT_166520.1 Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 888470 84590704 An03g04070 Aspergillus niger uncharacterized protein XP_059605224.1 888242 R 5061 CDS An03g04080 4980397 join(889123..889171,889265..891055,891256..891413) VI 1 NT_166520.1 Function: contains C2H2 type zinc-finger domains and might be involved in transcription.; Title: similarity to hypothetical protein YDR049w -Saccharomyces cerevisiae; uncharacterized protein 891413 4980397 An03g04080 Aspergillus niger uncharacterized protein XP_001390289.3 889123 D 5061 CDS An03g04090 4980398 join(891632..891793,891883..892089,892142..892249,892367..892465,892607..892902,892950..893373,893450..893623) VI 1 NT_166520.1 Catalytic activity: MEK1 catalyzes the formation of peptidyl-serine-phosphate or peptidyl-threonine-phosphate using ATP.; Function: MEK1 is involved in meiosis and DNA recombination.; Function: Ser/Thr-kinases of the MEK1 type are involved in multiple signal transduction events leading to the phosphorylation and therafter nuclear translocation of MAP-kinases.; Remark: alternate names for S. cerevisiae MAP-kinase kinase/meiotic kinase MEK1 are MRE4, O6357 and YOR351c.; Title: similarity to protein kinase Mek1 -Saccharomyces cerevisiae; cytoplasm; deleted EC_number 2.7.1.37; See PMID 9552352; See PMID 1741279; uncharacterized protein 893623 4980398 An03g04090 Aspergillus niger uncharacterized protein XP_059605225.1 891632 D 5061 CDS An03g04100 84590705 join(894296..894314,894662..894720,894815..894886,894969..895084,895167..895219,895485..895894) VI 1 NT_166520.1 Similarity: similarity is from predicted A. niger protein to N-terminal region of X. fastidiosa XF2713, which is 600 aa longer.; Title: similarity to hypothetical protein XF2713 -Xylella fastidiosa; uncharacterized protein 895894 84590705 An03g04100 Aspergillus niger uncharacterized protein XP_059605226.1 894296 D 5061 CDS An03g04110 4980400 join(896267..896452,896506..896589,896681..896740,896926..898359) VI 1 NT_166520.1 Remark: information about rat ARP has not been published and is available from EMBL.; Similarity: similarity is from the predicted A. niger protein to N-terminal half of rat ARP.; Title: weak similarity to hypothetical atrophin-1 related protein ARP - Rattus norvegicus; uncharacterized protein 898359 4980400 An03g04110 Aspergillus niger uncharacterized protein XP_001390292.3 896267 D 5061 CDS An03g04120 4980401 complement(join(899922..900910,900984..901320)) VI 1 NT_166520.1 Function: D. discoideum Amp1 is responsible for specially interacting with tyrosin-based sorting signals of integral membrane protein.; Function: the predicted A. niger protein shows similarity to several to clathrin coat assembly proteins of the AP50 superfamily, which mediate plasma membrane traffic.; Title: strong similarity to clathrin coat assembly protein Apm1 - Dictyostelium discoideum; See PMID 8996086; See PMID 10966473; uncharacterized protein 901320 4980401 An03g04120 Aspergillus niger uncharacterized protein XP_001390293.3 899922 R 5061 CDS An03g04130 4980402 complement(join(901972..902168,903237..904297,904348..904684,904911..905007,905092..905171,905302..905462,905559..905636,905789..905889)) VI 1 NT_166520.1 Remark: ORF might be questionable as similarities to other proteins are either partial or due to repeats. .; Title: weak similarity to hypothetical protein SPAC3F10.07c - Schizosaccharomyces pombe; uncharacterized protein 905889 4980402 An03g04130 Aspergillus niger uncharacterized protein XP_059605227.1 901972 R 5061 CDS An03g04140 4980403 join(905990..906161,906338..907284) VI 1 NT_166520.1 Function: NTA1 of S. cerevisiae is a component of a targeting complex in the N-end rule pathway of protein degradation.; Remark: alternative names of the S. cerevisiae protein are DEA1, J1742 and YJR062c.; Similarity: shows similarity to the N-terminal 2/3 of NTA1 only.; Title: strong similarity to N-terminal amidase Nta1 - Saccharomyces cerevisiae; cytoplasm; See PMID 7744855; uncharacterized protein 907284 4980403 An03g04140 Aspergillus niger uncharacterized protein XP_001390295.1 905990 D 5061 CDS An03g04150 84590706 join(907372..907391,907475..907733) VI 1 NT_166520.1 hypothetical protein 907733 84590706 An03g04150 Aspergillus niger hypothetical protein XP_059605228.1 907372 D 5061 CDS An03g04160 84590707 complement(join(907862..907957,908033..908221)) VI 1 NT_166520.1 hypothetical protein 908221 84590707 An03g04160 Aspergillus niger hypothetical protein XP_059605229.1 907862 R 5061 CDS An03g04170 84590708 join(908553..908645,908738..908847,908931..909028,909538..909582,909680..909795,909853..910437) VI 1 NT_166520.1 hypothetical protein 910437 84590708 An03g04170 Aspergillus niger hypothetical protein XP_059605230.1 908553 D 5061 CDS An03g04180 4980407 join(910670..911201,911260..911612) VI 1 NT_166520.1 Complex: human USF2 forms a complex with USF1.; Remark: USF2 isoforms in H. sapiens result from alternative splicing.; Remark: in human the CAGCTG element is recognized by the USF1 / USF2 complex.; Similarity: shows similarity to proteins containing a helix-loop-helix DNA-binding domain, i. e. several centromerbinding proteins.; Title: similarity to upstream stimulatory factor of transcription USF2 - Homo sapiens; nucleus; See PMID 8576131; See PMID 11180124; uncharacterized protein 911612 4980407 An03g04180 Aspergillus niger uncharacterized protein XP_003188634.1 910670 D 5061 CDS An03g04190 4980408 complement(join(913388..913801,913873..915033)) VI 1 NT_166520.1 Title: similarity to cellulase #2 from patent US2003036176-A1 - Xanthomonas campestris; uncharacterized protein 915033 4980408 An03g04190 Aspergillus niger uncharacterized protein XP_001390300.1 913388 R 5061 CDS An03g04200 84590709 join(915089..915205,915297..915348,915444..915629,915705..915814) VI 1 NT_166520.1 hypothetical protein 915814 84590709 An03g04200 Aspergillus niger hypothetical protein XP_059605231.1 915089 D 5061 CDS An03g04210 4980410 complement(join(916043..916123,916174..917091,917387..917532,917588..917723,917777..918217,918267..918383,918443..919431,919482..919683)) VI 1 NT_166520.1 Function: Sec8p and Sec15p of S. cerevisiae are components of a plasma membrane-associated 19. 5S particle,the exocyst, that may function downstream of Sec4p to control exocytosis.; Localization: depending on the analysed organism (S. cerevisiae, rat) 40-80% of the exocyst localises to the plasma membrane and the rest to the cytosole.; Similarity: shows similarity to the N-terminal half of sec8p only.; Title: similarity to component of the exocyst Sec8 -Saccharomyces cerevisiae; See PMID 10203793; See PMID 10973998; uncharacterized protein 919683 4980410 An03g04210 Aspergillus niger uncharacterized protein XP_059605232.1 916043 R 5061 CDS An03g04220 84590710 complement(919696..920148) VI 1 NT_166520.1 Remark: blastp with the predicted A. niger protein only retrieves random hits to serine rich proteins.; hypothetical protein 920148 84590710 An03g04220 Aspergillus niger hypothetical protein XP_059605233.1 919696 R 5061 CDS An03g04230 4980412 complement(join(921391..921638,921704..921748,921796..921880,921945..922779,922848..922893,922949..923170,923228..923289,923343..923508,923610..923669,923738..923813)) VI 1 NT_166520.1 Remark: human aminopeptidase P is a manganese(II)-dependent enzyme.; Similarity: shows strong similarity to aminopeptidases of different organisms.; Title: strong similarity to cytoplasmic form of aminopeptidase P - Homo sapiens; cytoplasm; See PMID 11106490; uncharacterized protein 923813 4980412 An03g04230 Aspergillus niger uncharacterized protein XP_001390304.3 921391 R 5061 CDS An03g04240 84590711 complement(join(924327..924475,924566..924673,924845..924941)) VI 1 NT_166520.1 Similarity: very weak similarity to bacterial proteins.; hypothetical protein 924941 84590711 An03g04240 Aspergillus niger hypothetical protein XP_059605234.1 924327 R 5061 CDS An03g04250 4980414 join(925009..925071,925128..925273,925335..925866,925931..928285) VI 1 NT_166520.1 Function: important targets of S. cerevisiae Kap122p is the complex of the large and small subunit (Toa1p and Toa2p, respectively) of the general transcription factor IIA (TFIIA).; Localization: S. cerevisiae Kap122p was localized both to the cytoplasm and the nucleus.; Similarity: by similarity rat lgl2 is a member of the karyopherin-beta family of nuclear import proteins.; Similarity: the predicted A. niger protein shows similarity to several karyopherin-beta proteins, among them S. cerevisiae KAP122 (formely PDR6).; Title: similarity to nuclear import protein LGL2 -Rattus norvegicus; See PMID 10525531; See PMID 10745026; uncharacterized protein 928285 4980414 An03g04250 Aspergillus niger uncharacterized protein XP_059605235.1 925009 D 5061 CDS An03g04260 84590712 join(928915..930046,930174..930292) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein CAD21410.1 - Neurospora crassa; uncharacterized protein 930292 84590712 An03g04260 Aspergillus niger uncharacterized protein XP_059605236.1 928915 D 5061 CDS An03g04270 84590713 complement(join(930308..930517,930981..931044,931138..931415)) VI 1 NT_166520.1 Remark: ORF might be questionable; Similarity: very weak similarity to different bacterial proteins.; hypothetical protein 931415 84590713 An03g04270 Aspergillus niger hypothetical protein XP_059605237.1 930308 R 5061 CDS An03g04280 4980417 complement(join(932590..933219,933289..933471,933540..933656)) VI 1 NT_166520.1 Function: Eukarya and Archaea exclusively use the pyroA pathway for pyridoxine synthesis.; Similarity: pyroA is highly conserved and belongs to the SNZ family.; Title: strong similarity to pyridoxine synthesis component pyroA - Aspergillus nidulans; See PMID 10438537; uncharacterized protein 933656 4980417 An03g04280 Aspergillus niger uncharacterized protein XP_001390309.1 932590 R 5061 CDS An03g04290 84590714 complement(933736..934125) VI 1 NT_166520.1 hypothetical protein 934125 84590714 An03g04290 Aspergillus niger hypothetical protein XP_059605238.1 933736 R 5061 CDS An03g04300 84590715 complement(join(934206..934286,934445..934569,934643..934676)) VI 1 NT_166520.1 Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 934676 84590715 An03g04300 Aspergillus niger uncharacterized protein XP_059605239.1 934206 R 5061 CDS An03g04310 4980420 join(934702..935076,935163..935315) VI 1 NT_166520.1 Remark: blastp shows similarity (47% positives) between predicted A. niger protein and S. cerevisiae FUN14,but due to shortness of both peptides the probability is low (p=0,32).; Title: similarity to hypothetical protein Fun14 -Saccharomyces cerevisiae; uncharacterized protein 935315 4980420 An03g04310 Aspergillus niger uncharacterized protein XP_001390312.1 934702 D 5061 CDS An03g04320 4980421 complement(join(935552..937248,937331..937428,937523..937560)) VI 1 NT_166520.1 Function: Cells lacking Orp2 undergo aberrant mitosis, indicating that Orp2 is involved in generating a checkpoint signal.; Function: Orp2 of S. pombe is required for DNA replication and interacts with the rate-limiting replication activator Cdc18.; Title: strong similarity to origin recognition complex protein orp2p - Schizosaccharomyces pombe; nucleus; See PMID 8552194; uncharacterized protein 937560 4980421 An03g04320 Aspergillus niger uncharacterized protein XP_059605240.1 935552 R 5061 CDS An03g04330 4980422 join(937959..938410,938482..939400) VI 1 NT_166520.1 Function: the enzyme of S. cerevisiae catalyses the freely reversible interchange of an acetyl group between N-acetylornithine and glutamate.; Localization: The enzyme was localised to the mitochondrial matrix and was found to be a 57-kDa heterodimer consisting of subunits of 31 kDa and 26 kDa.; Remark: alternate gene name is ECM40.; Remark: alternate protein names are ornithine acetyltransferase; protein YM9916. 01c; protein YMR062c.; Similarity: shows strong similarity to putative glutamate n-acetyltransferase precursor of S. pombe.; Title: strong similarity to glutamate N-acetyltransferase Arg7 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 7705341; uncharacterized protein 939400 4980422 An03g04330 Aspergillus niger uncharacterized protein XP_001390314.3 937959 D 5061 CDS An03g04340 4980423 complement(join(939815..939896,939954..941029,941102..941269,941328..941428,941518..941527)) VI 1 NT_166520.1 Function: the Sec61 protein is required for protein insertion in and translocation across the endoplasmic reticulum membrane.; Function: the Sec61 protein is required for protein translocation across the ER membrane in both yeast and mammals and is found in close association with polypeptides during their membrane transportation.; Similarity: Highly conserved, high sequence similarity to various species.; Title: strong similarity to ER membrane translocation facilitator Sec61 - Yarrowia lipolytica; endoplasmatic reticulum; See PMID 9427389; uncharacterized protein 941527 4980423 An03g04340 Aspergillus niger uncharacterized protein XP_001390315.1 939815 R 5061 CDS An03g04350 4980424 complement(join(942053..943759,943973..944110,944433..944684,944780..945004,945423..945512,945617..945929,946005..946063)) VI 1 NT_166520.1 Remark: blast hits result from repetitive sequences.; hypothetical protein 946063 4980424 An03g04350 Aspergillus niger hypothetical protein XP_059605241.1 942053 R 5061 CDS An03g04360 4980425 join(946102..946589,946636..946723) VI 1 NT_166520.1 Similarity: N-terminal part is similiar to central part of many different cyclins.; Title: strong similarity to hypothetical protein EAA61234.1 - Aspergillus nidulans; uncharacterized protein 946723 4980425 An03g04360 Aspergillus niger uncharacterized protein XP_001390317.3 946102 D 5061 CDS An03g04370 84590716 complement(join(946786..946843,946924..947141)) VI 1 NT_166520.1 hypothetical protein 947141 84590716 An03g04370 Aspergillus niger hypothetical protein XP_059605242.1 946786 R 5061 CDS An03g04380 4980427 join(947317..947843,947992..948355,948449..948544) VI 1 NT_166520.1 Alternative name: AUT1 or YNR007C.; Complex: Aut1p is subunit of the autophagy (Apg) conjugation complex reminiscent of the ubiquitin conjugation system, and is required for membrane recruitment of Apg7p and subsequent transport vesicle formation.; Function: Aut1p of S. cerevisiae is responsible for an unspecific bulk transpost of cytoplasmic proteins to the vacuole (CVT pathway) and is involved in autophagocytosis during starvation.; Title: strong similarity to autophagocytosis protein Aut1 - Saccharomyces cerevisiae; cytoplasm; See PMID 9023185; uncharacterized protein 948544 4980427 An03g04380 Aspergillus niger uncharacterized protein XP_059605243.1 947317 D 5061 CDS An03g04390 10098123 complement(join(949226..950119,950182..950440,950484..950644,950724..950781,951043..952384,952644..952899,953402..953510,953709..953773)) VI 1 NT_166520.1 Remark: blast hits result from repetitive sequences.; Title: weak similarity to S-layer protein -Clostridium thermocellum; uncharacterized protein 953773 10098123 An03g04390 Aspergillus niger uncharacterized protein XP_003188644.2 949226 R 5061 CDS An03g04400 4980429 complement(954095..954841) VI 1 NT_166520.1 Title: weak similarity to hypothetical protein encoded by An16g02860 - Aspergillus niger; uncharacterized protein 954841 4980429 An03g04400 Aspergillus niger uncharacterized protein XP_001390321.1 954095 R 5061 CDS An03g04410 4980430 complement(join(956533..956877,956955..957749,957877..957993)) VI 1 NT_166520.1 Function: The enzyme of S. cerevisiae is involved in protein N-linked glycosylation. It catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.; Localization: Topological studies indicate that UDP-glucose:dolichyl-phosphate glucosyltransferase is a transmembrane protein that spans the membrane several times.; Localization: UDP-glucose:dolichyl-phosphate glucosyltransferase of S. cerevisiae is a transmembrane-bound enzyme of the endoplasmic reticulum.; Similarity: Highest similarity to as yet unpublished dolichyl-phosphate beta-glucosyltransferase of Ajellomyces capsulata; Title: strong similarity to UDP-glucose:dolichyl-phosphate glucosyltransferase Alg5 -Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 8076653; uncharacterized protein 957993 4980430 An03g04410 Aspergillus niger uncharacterized protein XP_001390322.1 956533 R 5061 CDS An03g04420 84590717 join(958245..958350,958443..958546,958770..958802) VI 1 NT_166520.1 Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 958802 84590717 An03g04420 Aspergillus niger uncharacterized protein XP_059605244.1 958245 D 5061 CDS An03g04430 4980432 complement(join(958830..958875,959006..959085,959191..959304,959370..961494,961699..961823)) VI 1 NT_166520.1 Similarity: similarity to the aminoterminal part of probable membrane protein YIL151c and probable purine nucleotide-binding protein YKR096w of S. cerevisiae.; Title: strong similarity to hypothetical protein EAA61229.1 - Aspergillus nidulans; uncharacterized protein 961823 4980432 An03g04430 Aspergillus niger uncharacterized protein XP_059605245.1 958830 R 5061 CDS An03g04440 84590718 complement(join(<962269..962357,962590..962655,962801..962891,962991..963110,963251..963412,963616..963661,963847..963979)) VI 1 NT_166520.1 Remark: truncated ORF due to end of contig.; hypothetical protein [truncated ORF] 963979 84590718 An03g04440 Aspergillus niger hypothetical protein [truncated ORF] XP_059600282.1 962269 R 5061 CDS An03g04450 84590719 join(964057..964152,964247..964323,964423..964531,964755..964948,965020..965134,965301..965423) VI 1 NT_166520.1 hypothetical protein 965423 84590719 An03g04450 Aspergillus niger hypothetical protein XP_059600283.1 964057 D 5061 CDS An03g04460 84590720 complement(join(966278..966317,966401..966559,966615..966694)) VI 1 NT_166520.1 Similarity: similarity to N-terminal part of hypothetical glutamate-ammonia ligase VC2746 from Vibrio cholerae.; hypothetical protein 966694 84590720 An03g04460 Aspergillus niger hypothetical protein XP_059600284.1 966278 R 5061 CDS An03g04470 84590721 complement(join(966981..967354,967430..967503,967952..968012,968415..968464,968527..968615,968646..969713)) VI 1 NT_166520.1 Title: weak similarity to hypothetical zinc-finger protein 413R - Chilo iridescent virus; uncharacterized protein 969713 84590721 An03g04470 Aspergillus niger uncharacterized protein XP_059600285.1 966981 R 5061 CDS An03g04480 84590722 complement(join(970343..970520,970674..970714)) VI 1 NT_166520.1 hypothetical protein 970714 84590722 An03g04480 Aspergillus niger hypothetical protein XP_059600286.1 970343 R 5061 CDS An03g04485 84590723 complement(971109..971648) VI 1 NT_166520.1 hypothetical protein 971648 84590723 An03g04485 Aspergillus niger hypothetical protein XP_059600287.1 971109 R 5061 CDS An03g04500 4980439 join(972316..972741,972823..973329) VI 1 NT_166520.1 Title: similarity to hypothetical protein F16J13.50 - Arabidopsis thaliana; uncharacterized protein 973329 4980439 An03g04500 Aspergillus niger uncharacterized protein XP_001390331.3 972316 D 5061 CDS An03g04510 4980440 complement(join(973521..973759,973880..974120,974291..974383,974464..974514)) VI 1 NT_166520.1 Catalytic activity: ADP-ribose + H(2)O <=> AMP + D-ribose 5-phosphate.; Function: YSA1 of S. cerevisiae hydrolyzes ADP-ribose to AMP and ribose-5-phosphate; hydrolyzes ADP-mannose, ADP-glucose, and diadenosine diphosphate.; Remark: YSA1 probably plays a role in preventing the accumulation of nucleoside diphosphate-sugar intermediates in S. cerevisiae.; Remark: alternate names = YBR111C, YBR0907.; Title: strong similarity to Nudix (nucleoside diphosphate) hydrolase Ysa1 - Saccharomyces cerevisiae; See PMID 10542272; See PMID 8810257; uncharacterized protein 974514 4980440 An03g04510 Aspergillus niger uncharacterized protein XP_001390332.1 973521 R 5061 CDS An03g04520 4980441 complement(join(975098..976823,976892..977010)) VI 1 NT_166520.1 Catalytic activity: L-cysteine + cyanide <=> H(2)S + L-3-cyanoalanine.; Function: ILV-3 from S. cerevisiae is involved in that part of the biosynthesis of branched-chain amino acids (aa) through which pyruvate or alpha-ketobutyrate are converted into alpha-keto acids, precursors of valine,leucine or isoleucine.; Title: strong similarity to dihydroxy-acid dehydratase Ilv3 - Saccharomyces cerevisiae; See PMID 8299945; uncharacterized protein 977010 4980441 An03g04520 Aspergillus niger uncharacterized protein XP_001390333.1 975098 R 5061 CDS An03g04530 4980442 complement(join(978011..978736,978803..978811)) VI 1 NT_166520.1 Function: beta-PGM from L. lactis convertes beta-glucose 1-phosphate to glucose 6-phosphate.; Regulation: beta-PGM from L. lactis is maltose-inducible and glucose-repressible.; Remark: EC 5. 4. 2. 6; Title: similarity to beta-phosphoglucomutase beta-PGM - Lactococcus lactis; See PMID 9084169; uncharacterized protein 978811 4980442 An03g04530 Aspergillus niger uncharacterized protein XP_001390334.1 978011 R 5061 CDS An03g04540 84590724 join(979844..979946,980123..980313) VI 1 NT_166520.1 Remark: shows weak similarity to aa 170-260 from 1000 aa ror-related receptor RTK of Discopyge ommata.; hypothetical protein 980313 84590724 An03g04540 Aspergillus niger hypothetical protein XP_059600288.1 979844 D 5061 CDS An03g04550 4980444 join(980637..980989,981117..981151,981216..981388,981450..982346) VI 1 NT_166520.1 Function: RIT1 from S. cerevisiae encodes a phospho-ribosyl transferase that exclusively modifies the initiator tRNA (tRNAMet(i)) by the addition of a 2'-O-ribosyl phosphate group to Adenosine 64.; Function: Rit1 from S. cerevisiae is a tRNA backbone-modifying enzyme that mediates initiator and elongator tRNA discrimination.; Title: strong similarity to initiator tRNA phosphoribosyl-transferase Rit1 - Saccharomyces cerevisiae; See PMID 10485288; See PMID 7954819; uncharacterized protein 982346 4980444 An03g04550 Aspergillus niger uncharacterized protein XP_059600289.1 980637 D 5061 CDS An03g04560 4980445 complement(join(982403..982738,982821..983336)) VI 1 NT_166520.1 Catalytic activity: Alditol + NAD(P)(+) <=> aldose + NAD(P)H.; Function: the P. putida NADP(+)-dependent morphine dehydrogenase initiates morphine catabolism.; Remark: naloxone reductase is synonymous for morphine dehydrogenase.; Title: strong similarity to morphine dehydrogenase -Pseudomonas putida; uncharacterized protein 983336 4980445 An03g04560 Aspergillus niger uncharacterized protein XP_001390337.1 982403 R 5061 CDS An03g04570 4980446 join(985229..985284,985472..985538,985635..987242,987306..987509) VI 1 NT_166520.1 Remark: alpha-actinin from D. discoideum is 200 aa longer.; Similarity: non-muscle alpha-actinin from D. discoideum is Calcium-sensitive and contains EF-hand structures.; Title: similarity to actin cross-linking protein alpha-actinin - Dictyostelium discoideum; cytoskeleton; See PMID 10413681; uncharacterized protein 987509 4980446 An03g04570 Aspergillus niger uncharacterized protein XP_001390338.3 985229 D 5061 CDS An03g04580 84590725 join(988206..988244,988340..988402,988685..988716,988800..988837,988916..988976,989024..989099,989162..989854) VI 1 NT_166520.1 Title: similarity to hypothetical RNA binding protein CAB53728.1 - Schizosaccharomyces pombe; uncharacterized protein 989854 84590725 An03g04580 Aspergillus niger uncharacterized protein XP_059600290.1 988206 D 5061 CDS An03g04590 4980448 complement(join(990097..991087,991167..991262,991325..991364,991415..991528,991585..991594)) VI 1 NT_166520.1 Function: HET-E from P. anserina is responsible for vegetative incompatibility through specific interactions with different alleles of the unlinked gene, het-c.; Function: disruption of the het-e locus does not impair the phenotype of strains but DNA hybridization analyses revealed that het-e may belong to a multigenic family.; Remark: HET-E from P. anserina contains a functional GTP-binding site and WD40 repeats.; Title: similarity to beta transducin-like protein het-e - Podospora anserina; See PMID 9435787; See PMID 12019224; See PMID 7557402; uncharacterized protein 991594 4980448 An03g04590 Aspergillus niger uncharacterized protein XP_059600291.1 990097 R 5061 CDS An03g04600 4980449 join(992825..992872,992964..993417,993486..994370,994422..995365) VI 1 NT_166520.1 Complex: Ufd3p is an in vivo ligand of Cdc48p, an essential ATPase required for the cell cycle progression and the fusion of endoplasmic reticulum membranes.; Function: Ufd3p from S. cerevisiea is involved in the ubiquitin-dependent protein degradation.; Remark: UFD3 is synonymous for DOA1.; Title: strong similarity to WD-repeat protein required for ubiquitin-mediated proteolysis Doa1 -Saccharomyces cerevisiae; See PMID 8890162; uncharacterized protein 995365 4980449 An03g04600 Aspergillus niger uncharacterized protein XP_059600292.1 992825 D 5061 CDS An03g04610 4980450 complement(join(995632..996063,996226..996320,996388..996453,996510..996618,996689..996700)) VI 1 NT_166520.1 Function: it is proposed that the human GlcNAc thyroid receptor NAGR1 triggers selective recycling of immature GlcNAc-bearing thyroglobulin molecules through the Golgi back to the apical membrane for further processing until maturation is achieved.; Remark: human TGR-CL10C is 100 aa shorter.; Remark: no literature available for human TGR-CL10C,it is described only in Patent number WO9219733-A/13,12-NOV-1992.; Title: similarity to thyroidal receptor for N-acetylglucosamine TGR-CL10C - Homo sapiens; See PMID 8088785; uncharacterized protein 996700 4980450 An03g04610 Aspergillus niger uncharacterized protein XP_001390342.3 995632 R 5061 CDS An03g04620 4980451 join(997102..997178,997295..997553) VI 1 NT_166520.1 Title: strong similarity to mitochondrial ribosomal protein Cyt-21 - Neurospora crassa; localisation:mitochondrion; mitochondrial 37S ribosomal protein bS16m 997553 4980451 An03g04620 Aspergillus niger mitochondrial 37S ribosomal protein bS16m XP_001390343.3 997102 D 5061 CDS An03g04630 84590726 complement(join(997962..998057,998331..998457,998709..998780,998852..999000,999092..999217,999308..999415,999527..999637)) VI 1 NT_166520.1 hypothetical protein 999637 84590726 An03g04630 Aspergillus niger hypothetical protein XP_059600293.1 997962 R 5061 CDS An03g04640 84590727 complement(join(1001528..1001698,1001833..1001855,1001951..1002269,1002466..1002648)) VI 1 NT_166520.1 Similarity: weak similarity, due to central glycin and glutamic acid repeats, to retinitis pigmentosa GTPase regulator - Homo sapiens.; hypothetical protein 1002648 84590727 An03g04640 Aspergillus niger hypothetical protein XP_059600294.1 1001528 R 5061 CDS An03g04650 4980454 1002757..1004592 VI 1 NT_166520.1 Title: similarity to hypothetical RNA binding protein - Schizosaccharomyces pombe; uncharacterized protein 1004592 4980454 An03g04650 Aspergillus niger uncharacterized protein XP_001390346.1 1002757 D 5061 CDS An03g04660 4980455 join(1006188..1006682,1006938..1007606) VI 1 NT_166520.1 Similarity: shows similarity only in central part.; Title: weak similarity to hypothetical protein YGR165w - Saccharomyces cerevisiae; mitochondrial 37S ribosomal protein mS45 1007606 4980455 An03g04660 Aspergillus niger mitochondrial 37S ribosomal protein mS45 XP_001390347.1 1006188 D 5061 CDS An03g04670 4980456 complement(join(1008661..1009047,1009120..1009264,1009316..1009796,1009871..1011491)) VI 1 NT_166520.1 Title: similarity to response regulator mcs4p -Schizosaccharomyces pombe; See PMID 9136929; uncharacterized protein 1011491 4980456 An03g04670 Aspergillus niger uncharacterized protein XP_059600295.1 1008661 R 5061 CDS An03g04680 4980457 complement(join(1012840..1013174,1013204..1013252,1013410..1013553,1013610..1013681,1013935..1013969,1014073..1014253)) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein YDR090c - Saccharomyces cerevisiae; uncharacterized protein 1014253 4980457 An03g04680 Aspergillus niger uncharacterized protein XP_059600296.1 1012840 R 5061 CDS An03g04690 4980458 complement(join(1015417..1015935,1016000..1016122,1016183..1016338,1016405..1016473)) VI 1 NT_166520.1 Complex: SH3 domain of Sho1p from S. cerevisiae interacts with Pbs2 (MAPKK).; Function: Sho1p from S. cerevisiae activates the HOG p38 MAPK-pathway during osmotic stress.; Remark: Yeast cdc42 GTPase and ste20 PAK-like kinase regulate Sho1-dependent activation of the hog1 MAPK pathway; Title: strong similarity to hypothetical osmosensor Sho1p - Candida utilis; plasma membrane; See PMID 10970855; See PMID 10980703; See PMID 11118628; uncharacterized protein 1016473 4980458 An03g04690 Aspergillus niger uncharacterized protein XP_001390350.3 1015417 R 5061 CDS An03g04700 4980459 complement(join(1018468..1018612,1018809..1018922,1018957..1019024,1019054..1019167,1019260..1019297,1019454..1019551,1019603..1019831,1019914..1019929,1020075..1020451,1020508..1020739)) VI 1 NT_166520.1 Function: RO10 of N. crassa, as well as RO4 (actin-related protein ARP1, the most abundant subunit of dynactin), appears to be required for the stability of RO3 (p150Glued), the largest subunit of dynactin.; Similarity: RO10 from N. crassa is 200 aa shorter.; Title: strong similarity to RO10 - Neurospora crassa; See PMID 10361308; uncharacterized protein 1020739 4980459 An03g04700 Aspergillus niger uncharacterized protein XP_059600297.1 1018468 R 5061 CDS An03g04710 4980460 complement(join(1021338..1021460,1021521..1021960,1022000..1023232,1023291..1023426,1023501..1023534,1023603..1023640)) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein CAD21392.1 - Neurospora crassa; uncharacterized protein 1023640 4980460 An03g04710 Aspergillus niger uncharacterized protein XP_059600298.1 1021338 R 5061 CDS An03g04720 4980461 join(1025491..1025897,1025984..1026819,1026906..1027538,1027623..1028143) VI 1 NT_166520.1 Function: production of cell wall-degrading enzymes (wall depolymerases) by plant pathogenic fungi is under catabolite (glucose) repression.; Title: strong similarity to serine threonine protein kinase SNF1 - Cochliobolus carbonum; See PMID 10662860; uncharacterized protein 1028143 4980461 An03g04720 Aspergillus niger uncharacterized protein XP_059600299.1 1025491 D 5061 CDS An03g04730 4980462 join(1028567..1028580,1028713..1030633) VI 1 NT_166520.1 Similarity: only N-terminal 70 aa show similarity to C-terminus of krox-20 M. musculus.; Title: weak similarity to zinc-finger protein krox-20 - Mus musculus; See PMID 2496302; uncharacterized protein 1030633 4980462 An03g04730 Aspergillus niger uncharacterized protein XP_001390354.3 1028567 D 5061 CDS An03g04740 4980463 complement(join(1030688..1031273,1031339..1031825,1031889..1031930,1031997..1032249,1032504..1032533,1032697..1032851,1032910..1033097,1033413..1033423)) VI 1 NT_166520.1 Similarity: FLU1 from C. albicans belongs to the major facilitator family.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; plasma membrane; See PMID 11065353; uncharacterized protein 1033423 4980463 An03g04740 Aspergillus niger uncharacterized protein XP_059600300.1 1030688 R 5061 CDS An03g04750 4980464 join(1034127..1034174,1034255..1035045,1035109..1035164,1035228..1035500,1035587..1035707,1035793..1035893,1035999..1036063) VI 1 NT_166520.1 Catalytic activity: Salicylate + NADH + O(2) <=> catechol + NAD(+) + H(2)O + CO(2).; Remark: systematic name of salicylate hydroxylase is Salicylate 1-monooxygenase; Title: similarity to salicylate hydroxylase -Sphingomonas sp.; See PMID 10348858; uncharacterized protein 1036063 4980464 An03g04750 Aspergillus niger uncharacterized protein XP_059600301.1 1034127 D 5061 CDS An03g04760 4980465 complement(join(1036261..1036356,1036426..1036759,1036821..1036995,1037067..1037392,1037441..1037461,1037508..1037619,1037673..1037706,1037755..1038578,1038648..1038685,1038787..1038918,1039322..1040058,1040141..1040443)) VI 1 NT_166520.1 Title: similarity to protein sequence #124 from patent WO200224865-A2 - Unclassified organism; uncharacterized protein 1040443 4980465 An03g04760 Aspergillus niger uncharacterized protein XP_059600302.1 1036261 R 5061 CDS An03g04770 4980466 complement(join(1045225..1046942,1047022..1047154,1047231..1047436,1047508..1047523)) VI 1 NT_166520.1 Function: the forkhead-associated (FHA) domain is a putative nuclear signalling domain found in a variety of otherwise unrelated proteins.; Similarity: shows only partial similarity to forkhead-containing proteins.; Title: similarity to hypothetical protein CAD11383.1 - Neurospora crassa; uncharacterized protein 1047523 4980466 An03g04770 Aspergillus niger uncharacterized protein XP_059600303.1 1045225 R 5061 CDS An03g04780 84590728 complement(join(1047960..1048118,1048208..1048440,1048613..1048706)) VI 1 NT_166520.1 Similarity: shows similarity at the aminoterminus to several proteins being mitochondrial NADH dehydrogenase subunit II which might be due to false gene prediction or the ORF might represent a pseudogene.; Title: weak similarity to hypothetical NADH dehydrogenase subunit II ND2 - Mesaspis moreleti; uncharacterized protein 1048706 84590728 An03g04780 Aspergillus niger uncharacterized protein XP_059600304.1 1047960 R 5061 CDS An03g04790 4980468 complement(join(1049126..1049373,1049435..1049908,1049961..1050732,1050804..1050886,1050958..1051270)) VI 1 NT_166520.1 Function: Tom70 is implicated in the import of proteins from the cytosol into the mitochondria in S. cerevisiae and Neurospora crassa.; Function: it has been proposed that TPR proteins preferably interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.; Function: prominent examples of TPR-proteins include, Cdc16p, Cdc23p and Cdc27p components of the cyclosome/APC, the Pex5p/Pas10p receptor for peroxisomal targeting signals, the Tom70p co-receptor for mitochondrial targeting signals, Ser/Thr phosphatase 5C and the p110 subunit of O-GlcNAc transferase.; Function: the mitochondrial outer membrane plays a role in the stability of the mitochondrial genome in an obligate aerobe, probably through the import process.; Title: strong similarity to mitochondrial outer membrane protein Tom70 - Podospora anserina; localisation:mitochondrion; See PMID 9343397; uncharacterized protein 1051270 4980468 An03g04790 Aspergillus niger uncharacterized protein XP_001390360.1 1049126 R 5061 CDS An03g04800 4980469 join(1051462..1051630,1051791..1052612,1052702..1052770,1052865..1052945,1053087..1053289) VI 1 NT_166520.1 Title: similarity to hypothetical protein YMR289w -Saccharomyces cerevisiae; uncharacterized protein 1053289 4980469 An03g04800 Aspergillus niger uncharacterized protein XP_001390361.3 1051462 D 5061 CDS An03g04810 4980470 1053825..1054637 VI 1 NT_166520.1 Function: PRELI might be involved in maturation of human tissue.; Similarity: PRELI is almost identical to human PX19,that is also in the blast hits list and shows similarity to fungal hypothetical proteins like that resulting from the present ORF.; Title: weak similarity to protein of relevant evolutionary and lymphoid interest PRELI - Homo sapiens; See PMID 10784606; uncharacterized protein 1054637 4980470 An03g04810 Aspergillus niger uncharacterized protein XP_001390362.1 1053825 D 5061 CDS An03g04820 4980471 1055506..1056363 VI 1 NT_166520.1 Similarity: the ORF also shows weak similarity at pos. 5 to 86 to several viral polyproteins.; Similarity: the ORF shows strong similarity to the A. niger protein An12g06110 along a stretch of about 80 amino acids.; Title: similarity to hypothetical protein encoded by An12g06110 - Aspergillus niger; uncharacterized protein 1056363 4980471 An03g04820 Aspergillus niger uncharacterized protein XP_001390363.1 1055506 D 5061 CDS An03g04830 84590729 join(1059988..1060114,1060351..1060436,1060497..1060862) VI 1 NT_166520.1 hypothetical protein 1060862 84590729 An03g04830 Aspergillus niger hypothetical protein XP_059600305.1 1059988 D 5061 CDS An03g04840 4980473 join(1062584..1063145,1063206..1063459) VI 1 NT_166520.1 Similarity: shows weak partial similarity to Hepatitis C virus sequences.; hypothetical protein 1063459 4980473 An03g04840 Aspergillus niger hypothetical protein XP_001390365.1 1062584 D 5061 CDS An03g04850 4980474 complement(1064165..1064683) VI 1 NT_166520.1 Similarity: shows weak similarity to decarboxylases of several species.; Title: weak similarity to p-coumaric acid decarboxylase pdc - Lactobacillus plantarum; See PMID 9143125; uncharacterized protein 1064683 4980474 An03g04850 Aspergillus niger uncharacterized protein XP_001390366.1 1064165 R 5061 CDS An03g04860 4980475 join(1067655..1067696,1067801..1068067,1068224..1068442) VI 1 NT_166520.1 Function: NCE102 of S. cerevisiae may be a component of the non-classical export machinery.; Title: strong similarity to protein involved in non-classical protein export pathway Nce102 - Saccharomyces cerevisiae; See PMID 8655575; uncharacterized protein 1068442 4980475 An03g04860 Aspergillus niger uncharacterized protein XP_001390367.1 1067655 D 5061 CDS An03g04870 4980476 1069220..1070257 VI 1 NT_166520.1 Function: contains a domain specific for Zinc-binding dehydrogenases.; Function: synthesis of the main nonaketide-derived skeleton was found to require the previously known iterative lovastatin nonaketide synthase (LNKS), plus at least one additional protein (LovC) that interacts with LNKS and is necessary for the correct processing of the growing polyketide chain and production of dihydromonacolin L.; Function: the lovastatin biosynthesis cluster contains two type I polyketide synthase genes.; Similarity: shows similarity to Zinc-binding dehydrogenases.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994; uncharacterized protein 1070257 4980476 An03g04870 Aspergillus niger uncharacterized protein XP_001390368.1 1069220 D 5061 CDS An03g04880 4980477 join(1070746..1070945,1071015..1071223,1071282..1071533,1071582..1071802,1071855..1072247,1072278..1072368,1072422..1073690,1073837..1074423,1074477..1074591,1074632..1075344) VI 1 NT_166520.1 Function: Ycf1p of S. cerevisiae selectively catalyzes the transport of glutathione-conjugated cadmium for detoxification in vacuoles.; Localization: Ycf1p is a vacuolar integral membrane protein.; Title: strong similarity to cadmium resistance protein Ycf1 - Saccharomyces cerevisiae; See PMID 8990158; uncharacterized protein 1075344 4980477 An03g04880 Aspergillus niger uncharacterized protein XP_059600306.1 1070746 D 5061 CDS An03g04890 4980478 complement(join(1076260..1076365,1076420..1076637,1076696..1076729,1076782..1076871,1076927..1077083,1077141..1077153,1077211..1077368,1077424..1077442,1077513..1077618,1077784..1077875)) VI 1 NT_166520.1 Catalytic activity: catalyzes the cyclization of farnesyl diphosphate to the tricyclic sesquiterpene hydrocarbon pentalenene.; Function: belongs to the family of phosphorus-oxygen lyases.; Function: pentalenene synthase is involved in the biosynthesis of pentalenolactone and related antibiotics.; Title: strong similarity to pentalenene synthase -Streptomyces sp.; uncharacterized protein 1077875 4980478 An03g04890 Aspergillus niger uncharacterized protein XP_059600307.1 1076260 R 5061 CDS An03g04900 4980479 join(1079139..1079540,1079600..1080328,1080381..1080630,1080698..1080801) VI 1 NT_166520.1 Title: similarity to hypothetical protein CAB91439.2 - Neurospora crassa; uncharacterized protein 1080801 4980479 An03g04900 Aspergillus niger uncharacterized protein XP_001390371.3 1079139 D 5061 CDS An03g04910 4980480 join(1084132..1084173,1084625..1084742,1084840..1085114,1085356..1085391) VI 1 NT_166520.1 Complex: adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles.; Function: adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes.; Remark: ORF might be questionable, especially at the aminoterminus (no similarity around start; large intron).; Similarity: adaptins seem to be conserved over all species.; Title: strong similarity to clathrin coat assembly protein AP19 - Camptotheca acuminata; intracellular transport vesicles; See PMID 9002613; See PMID 9653655; uncharacterized protein 1085391 4980480 An03g04910 Aspergillus niger uncharacterized protein XP_059600308.1 1084132 D 5061 CDS An03g04920 4980481 join(1085984..1085989,1086068..1087048) VI 1 NT_166520.1 Phenotype: in S. cerevisiae the maf1 mutant shows a an altered intracellular localization of the Mod5p-I protein.; Remark: at about position 90 of the ORF encoded protein the Maf1p of S. cerevisiae has an extra 130 amino acids.; Title: similarity to Maf1 - Saccharomyces cerevisiae; See PMID 7732762; uncharacterized protein 1087048 4980481 An03g04920 Aspergillus niger uncharacterized protein XP_001390373.1 1085984 D 5061 CDS An03g04930 4980482 join(1087684..1087740,1087881..1088729,1088812..1090116) VI 1 NT_166520.1 Title: similarity to hypothetical protein 12F11.80 -Neurospora crassa; uncharacterized protein 1090116 4980482 An03g04930 Aspergillus niger uncharacterized protein XP_059600309.1 1087684 D 5061 CDS An03g04940 4980483 complement(join(1090542..1091059,1091137..1091727,1091877..1091967)) VI 1 NT_166520.1 Function: A cell-free assay that reproduces transport between the ER and Golgi indicates that deletion of the Erv41p-Erv46p complex in S. cerevisiae influences the membrane fusion stage of transport.; Localization: Erv41p of S. cerevisiae colocalizes to ER and Golgi membranes and exists in a detergent-soluble complex that was isolated by immunoprecipitation.; Remark: YML067C is the systematic name for ERV41.; Title: strong similarity to Erv41 - Saccharomyces cerevisiae; See PMID 11157978; uncharacterized protein 1091967 4980483 An03g04940 Aspergillus niger uncharacterized protein XP_001390375.1 1090542 R 5061 CDS An03g04950 4980484 <1092783..1093628 VI 1 NT_166520.1 Remark: the ORF is N-terminally truncated due to the contig end.; Title: similarity to hypothetical protein encoded by An15g02610 - Aspergillus niger [truncated ORF]; uncharacterized protein 1093628 4980484 An03g04950 Aspergillus niger uncharacterized protein XP_001390376.3 1092783 D 5061 CDS An03g04960 4980485 complement(join(1094605..1098631,1098773..1098953,1099038..1099143)) VI 1 NT_166520.1 Function: when expressed in E. coli, DYRK2 catalyzes its autophosphorylation on tyrosine residues. DYRK2 phosphorylates histone H2B.; Similarity: the C-terminus of the predicted A. niger protein shows strong similarity to human protein kinase DYRK2, which belongs to a new family of protein kinases comprising at least seven mammalian isoforms (DYRK1A,DYRK1B, DYRK1C, DYRK2, DYRK3, DYRK4A, and DYRK4B), the yeast homolog Yak1p, and the Drosophila kinase minibrain (MNB).; Title: similarity to protein kinase DYRK2 - Homo sapiens; See PMID 9748265; uncharacterized protein 1099143 4980485 An03g04960 Aspergillus niger uncharacterized protein XP_059600310.1 1094605 R 5061 CDS An03g04970 4980486 join(1100184..1100344,1100418..1100558,1100615..1101892,1102230..1102250,1102327..1102386,1102480..1102600,1102681..1102986,1103038..1103548,1103600..1107177) VI 1 NT_166520.1 Function: cMrp of R. norvegicus is an organic anion and multidrug transporter.; Localization: rat cMrp is localized exclusively to the canalicular membrane domain of hepatocytes.; Similarity: cMrp of R. norvegicus is a member of the ABC transporter superfamily.; Title: strong similarity to canalicular multidrug resistance protein cMrp - Rattus norvegicus; plasma membrane; See PMID 8662992; uncharacterized protein 1107177 4980486 An03g04970 Aspergillus niger uncharacterized protein XP_001390378.3 1100184 D 5061 CDS An03g04980 84590730 complement(join(1107433..1108373,1108437..1108480,1108542..1108690)) VI 1 NT_166520.1 Title: weak similarity to hypothetical protein YHL028w - Saccharomyces cerevisiae; uncharacterized protein 1108690 84590730 An03g04980 Aspergillus niger uncharacterized protein XP_059600311.1 1107433 R 5061 CDS An03g04990 4980488 complement(join(1109287..1109875,1109953..1110083)) VI 1 NT_166520.1 Remark: the reserved name for YER002w of S. cerevisiae is NOP16, based on the suggestion, that NOP16 is a putative nucleolar protein.; Title: similarity to hypothetical protein YER002w -Saccharomyces cerevisiae; uncharacterized protein 1110083 4980488 An03g04990 Aspergillus niger uncharacterized protein XP_001390380.1 1109287 R 5061 CDS An03g05000 4980489 join(1110386..1110529,1110628..1110778,1110835..1111814,1111859..1111957) VI 1 NT_166520.1 Title: similarity to human transmembrane protein HTMPN-73 from patent WO9961471-A2 - Homo sapiens; plasma membrane; uncharacterized protein 1111957 4980489 An03g05000 Aspergillus niger uncharacterized protein XP_059600312.1 1110386 D 5061 CDS An03g05010 4980490 complement(1112455..1113633) VI 1 NT_166520.1 Function: MNN9 isrequired for the synthesis of N-linked outer-chain mannan.; Golgi; Phenotype: disruption of MNN9 leads to phenotypic effects characteristic of cell wall defects including poor growth in liquid media and on solid media, formation of aggregates in liquid culture, osmotic sensitivity, aberrant hyphal formation, and increased sensitivity to lysis after treatment with beta-1,3-glucanase.; Remark: mannoproteins are a major component of the fungal cell wall and contain mannose in either O- or N-glycosidic linkages.; Title: strong similarity to cell wall biosynthesis protein MNN9 - Candida albicans; See PMID 10601199; uncharacterized protein 1113633 4980490 An03g05010 Aspergillus niger uncharacterized protein XP_059600313.1 1112455 R 5061 CDS An03g05020 4980491 complement(join(1114446..1114865,1114923..1115151,1115292..1115447,1115552..1115561,1115639..1115747)) VI 1 NT_166520.1 Function: CACT transports acylcarnitines into mitochondria in exchange for free carnitine.; Pathway: CACT is essential for the fatty acid beta-oxidation pathway.; Title: strong similarity to carnitine/acylcarnitine translocase CACT - Homo sapiens; localisation:mitochondrion; See PMID 9837782; See PMID 11162577; uncharacterized protein 1115747 4980491 An03g05020 Aspergillus niger uncharacterized protein XP_059600314.1 1114446 R 5061 CDS An03g05030 4980492 complement(1116990..>1117394) VI 1 NT_166520.1 Remark: N-terminally truncated due to contig border.; hypothetical protein [truncated ORF] 1117394 4980492 An03g05030 Aspergillus niger hypothetical protein [truncated ORF] XP_001390384.3 1116990 R 5061 CDS An03g05040 84590731 complement(join(1118985..1119227,1119369..1119488,1119570..1119630,1119844..1120104,1120255..1120416,1120856..1121144,1121296..1121357,1121432..1121501,1121626..1121756,1121891..1121978,1122116..1122125)) VI 1 NT_166520.1 Title: similarity to EST an_2087 - Aspergillus niger; uncharacterized protein 1122125 84590731 An03g05040 Aspergillus niger uncharacterized protein XP_059605877.1 1118985 R 5061 CDS An03g05050 4980494 complement(join(1123171..1123490,1123547..1124018)) VI 1 NT_166520.1 Function: the lvr gene product of C. aquaticum is an oxido-reductase catalyzing reduction of (6R)-2,2,6-trimethl-1,4-cyclohexanedione to (4R,6R)-4-hydroxy-2,2,6-trimethylcyclohexanone.; Similarity: strong similarity to EST an_2379 Aspergillus niger.; Title: strong similarity to levodione reductase lvr - Corynebacterium aquaticum; See PMID 10508066; uncharacterized protein 1124018 4980494 An03g05050 Aspergillus niger uncharacterized protein XP_001390386.1 1123171 R 5061 CDS An03g05060 4980495 join(1125263..1125354,1125381..1125458,1125511..1125743,1125805..1126651,1126703..1127084) VI 1 NT_166520.1 Title: strong similarity to choline permease Hnm1 -Saccharomyces cerevisiae; plasma membrane; See PMID 7520996; See PMID 8264542; See PMID 1878995; See PMID 2203793; See PMID 2249250; uncharacterized protein 1127084 4980495 An03g05060 Aspergillus niger uncharacterized protein XP_059605878.1 1125263 D 5061 CDS An03g05070 4980496 complement(join(1127237..1127448,1127552..1127777,1127845..1127887,1127942..1127963,1128106..1128269,1128297..1128511,1128567..1128833)) VI 1 NT_166520.1 Catalytic activity: agmatine + H(2)O = putrescine + urea.; Function: the S. clavuligerus pah gene product is involved in clavulanic acid biosynthesis.; Title: strong similarity to proclavaminic acid amidino hydrolase pah - Streptomyces clavuligerus; See PMID 8088547; See PMID 8529893; uncharacterized protein 1128833 4980496 An03g05070 Aspergillus niger uncharacterized protein XP_059605879.1 1127237 R 5061 CDS An03g05080 4980497 join(1129277..1129279,1129356..1129463,1129515..1129549,1129626..1129968,1130037..1130147) VI 1 NT_166520.1 Title: similarity to hypothetical protein YKL069w -Saccharomyces cerevisiae; uncharacterized protein 1130147 4980497 An03g05080 Aspergillus niger uncharacterized protein XP_059605880.1 1129277 D 5061 CDS An03g05090 4980498 complement(join(1130729..1131240,1131304..1132309)) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein associated with ferric reductase activity Utr1 -Saccharomyces cerevisiae; uncharacterized protein 1132309 4980498 An03g05090 Aspergillus niger uncharacterized protein XP_001390390.3 1130729 R 5061 CDS An03g05100 4980499 complement(join(1134408..1134821,1134915..1135250)) VI 1 NT_166520.1 Complex: hRrp46 is part of the nuclear/nucleolar particle termed PM-Scl (polymyositis/scleroderma). the PM-Scl complex consists of 11 to 16 proteins.; Remark: the PM/Scl complex is the human counterpart of the yeast (S. cerevisiae) exosome, which is an RNA-processing complex consisting of 11 3' --> 5' exoribonucleases.; Remark: the exosome plays a major role in diverse RNA processing and degradation pathways.; Similarity: the predicted A. niger protein shows similarity to the human exosome component Rrp46 (hRrp46).; Title: similarity to exosome component Rrp46 - Homo sapiens; See PMID 11110791; uncharacterized protein 1135250 4980499 An03g05100 Aspergillus niger uncharacterized protein XP_001390391.1 1134408 R 5061 CDS An03g05110 4980500 join(1136772..1136835,1136899..1137620) VI 1 NT_166520.1 Title: similarity to hypothetical protein BAB11562.1 - Arabidopsis thaliana; uncharacterized protein 1137620 4980500 An03g05110 Aspergillus niger uncharacterized protein XP_001390392.1 1136772 D 5061 CDS An03g05120 4980501 complement(join(1137898..1138265,1138339..1138706,1138795..1139154,1139217..1139360,1139486..1139758,1139815..1140005)) VI 1 NT_166520.1 Remark: patentmatch against protein AX066343 Tremblnew.; Title: strong similarity to sequence 247 from patent WO0100804 - Corynebacterium glutamicum; plasma membrane; uncharacterized protein 1140005 4980501 An03g05120 Aspergillus niger uncharacterized protein XP_059605881.1 1137898 R 5061 CDS An03g05130 4980502 complement(join(1140471..1140994,1141055..1141151,1141225..1141252,1141312..1141325)) VI 1 NT_166520.1 Title: similarity to hypothetical dihydrofolate reductase CAB16576.1 - Schizosaccharomyces pombe; uncharacterized protein 1141325 4980502 An03g05130 Aspergillus niger uncharacterized protein XP_001390394.1 1140471 R 5061 CDS An03g05140 4980503 join(1141908..1142543,1142608..1142956,1143012..1143096,1143144..1143303,1143353..1143886,1143936..1143963,1144107..1144266,1144328..1145373,1145478..1145718,1145775..1146678,1146732..1147067,1147115..1147176,1147230..1147318,1147365..1149124,1149172..1149509,1149577..1150384) VI 1 NT_166520.1 Title: strong similarity to polyketide synthase PKS1 - Cochliobolus heterostrophus; See PMID 7500937; See PMID 8953776; uncharacterized protein 1150384 4980503 An03g05140 Aspergillus niger uncharacterized protein XP_059605882.1 1141908 D 5061 CDS An03g05150 4980504 join(1150653..1150965,1151054..1151784) VI 1 NT_166520.1 Function: the R. graminis D-mandelate dehydrogenase is the first enzyme of the mandelate pathway and catalyses the NAD(+)-dependent oxidation of D(--)-mandelate to phenylglyoxylate.; Title: strong similarity to D-mandelate dehydrogenase - Rhodotorula graminis; See PMID 8343125; See PMID 8411179; See PMID 9639569; See PMID 1731758; uncharacterized protein 1151784 4980504 An03g05150 Aspergillus niger uncharacterized protein XP_001390396.1 1150653 D 5061 CDS An03g05160 4980505 complement(join(1151934..1152328,1152379..1152540,1152587..1152995,1153081..1153266,1153332..1153396,1153451..1154069)) VI 1 NT_166520.1 Function: the FRE2 protein of S. cerevisiae is a plasma membrane bound ferric/cupric reductase and facilitates copper uptake.; Title: similarity to ferric/cupric reductase Fre2 -Saccharomyces cerevisiae; plasma membrane; See PMID 8164662; See PMID 9153234; See PMID 10341420; See PMID 11120744; uncharacterized protein 1154069 4980505 An03g05160 Aspergillus niger uncharacterized protein XP_001390397.1 1151934 R 5061 CDS An03g05170 4980506 complement(1156344..1159292) VI 1 NT_166520.1 Function: the H. sapiens srebp-1 protein act as a transcriptional activator that binds to the sterol regulatory element 1 (sre-1) (5'-atcaccccac-3') found in the flanking region of the ldrl gene as well as other genes.; Remark: the H. sapiens srebp-1 protein is attached to the membranes of the nuclear envelope and endoplasmic reticulum and is released into the nucleus upon proteolytic cleavage.; Title: similarity to sterol regulatory element binding protein-1 srebp-1 - Homo sapiens; nucleus; uncharacterized protein 1159292 4980506 An03g05170 Aspergillus niger uncharacterized protein XP_001390398.3 1156344 R 5061 CDS An03g05180 84590732 join(1159476..1159636,1159749..1159837,1160052..1160288,1160405..1160472,1160562..1160640,1160722..1160794,1160896..1160996,1161138..1161223) VI 1 NT_166520.1 Title: weak similarity to hypothetical protein E2 -Human papillomavirus; uncharacterized protein 1161223 84590732 An03g05180 Aspergillus niger uncharacterized protein XP_059605883.1 1159476 D 5061 CDS An03g05190 4980508 join(1162226..1162351,1162433..1163383) VI 1 NT_166520.1 Catalytic activity: L-iditol + NAD(+) = L-sorbose + NADH.; Remark: two isoforms of SDH1 from R. norvegicus are produced by use of alternative initiation codons in the same reading frame.; Title: strong similarity to sorbitol dehydrogenase SDH1 - Rattus norvegicus; See PMID 8223590; See PMID 8761460; uncharacterized protein 1163383 4980508 An03g05190 Aspergillus niger uncharacterized protein XP_059605884.1 1162226 D 5061 CDS An03g05200 4980509 join(1163880..1164159,1164210..1164754,1164813..1165688) VI 1 NT_166520.1 Title: strong similarity to carboxypeptidase S1 -Penicillium janthinellum; See PMID 8224168; uncharacterized protein 1165688 4980509 An03g05200 Aspergillus niger uncharacterized protein XP_001390401.1 1163880 D 5061 CDS An03g05210 4980510 join(1166379..1166634,1166702..1167867) VI 1 NT_166520.1 Catalytic activity: (S)-reticuline + O(2) = (S)-scoulerine + H(2)O(2).; Function: the E. californica bbe1 gene product is essential to the formation of benzophenanthridine alkaloids in the response of plants to pathogenic attack.; Remark: The product of the reaction, (S)-scoulerine,is a precursor of protopine, protoberberine and benzophenanthridine alkaloid biosynthesis in plants.; Title: strong similarity to reticuline oxidase bbe1 - Eschscholzia californica; See PMID 7592663; See PMID 7764480; See PMID 9484487; See PMID 1946465; uncharacterized protein 1167867 4980510 An03g05210 Aspergillus niger uncharacterized protein XP_001390402.1 1166379 D 5061 CDS An03g05220 4980511 complement(join(1167971..1168410,1168538..1168756,1168816..1169101)) VI 1 NT_166520.1 Title: similarity to hypothetical protein CAD70321.1 - Neurospora crassa; uncharacterized protein 1169101 4980511 An03g05220 Aspergillus niger uncharacterized protein XP_059605885.1 1167971 R 5061 CDS An03g05230 84590733 join(1169960..1170023,1170073..1170290) VI 1 NT_166520.1 Remark: patentmatch against protein ORF 01ae12021orf5 protein AC W55192 Geneseqprot.; Title: weak similarity to protein from patent WO9737044-A1 - Helicobacter pylori; uncharacterized protein 1170290 84590733 An03g05230 Aspergillus niger uncharacterized protein XP_059605886.1 1169960 D 5061 CDS An03g05240 4980513 complement(1170777..1172054) VI 1 NT_166520.1 Title: similarity to myo-inositol dehydrogenase idhA - Sinorhizobium meliloti; See PMID 9802033; uncharacterized protein 1172054 4980513 An03g05240 Aspergillus niger uncharacterized protein XP_001390405.1 1170777 R 5061 CDS An03g05250 4980514 join(1172473..1172959,1173013..1173110,1173163..1173521,1173574..1173835,1173897..1174016,1174082..1174182,1174244..1174367,1174486..1174533) VI 1 NT_166520.1 Induction: in S. cerevisiae the relatively high basal level of DAL5 expression did not increase further upon addition of allantoin pathway intermediates.; Remark: alternative names are YJR152w, UREP1.; Repression: in S. cerevisiae steady-state DAL5 mRNA levels dropped precipitously when a repressive nitrogen source was provided.; Similarity: belongs to the permeases of the major facilitator superfamily.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 3275614; See PMID 3301804; See PMID 10869563; uncharacterized protein 1174533 4980514 An03g05250 Aspergillus niger uncharacterized protein XP_059605887.1 1172473 D 5061 CDS An03g05260 4980515 complement(join(1174655..1174824,1174880..1174935,1175017..1175109,1175182..1175346,1175399..1175601,1175658..1175924)) VI 1 NT_166520.1 Catalytic activity: endohydrolysis of beta-1,4-linkages between N-acetyl-D-glucosamine and D-glucosamine residues in a partly acetylated chitosan.; Pathway: aminosugars metabolism.; Remark: by endo-splitting activity, the chitosanase hydrolysed chitosan to form chitosan oligomers with chitotriose, chitotetraose and chitopentaose as the major products. The enzyme hydrolyses chitohexaose to form chitotriose, while the chitopentaose and shorter oligomers remain intact.; Title: similarity to chitosanase csnA - Aspergillus oryzae; See PMID 11055393; See PMID 11388486; uncharacterized protein 1175924 4980515 An03g05260 Aspergillus niger uncharacterized protein XP_059605888.1 1174655 R 5061 CDS An03g05270 84590734 join(1175947..1176295,1176385..1176560,1176631..1176741,1176979..1177008) VI 1 NT_166520.1 Title: weak similarity to hypothetical C-terminal region of hypothetical protein NMB0928 - Neisseria meningitidis; uncharacterized protein 1177008 84590734 An03g05270 Aspergillus niger uncharacterized protein XP_059605889.1 1175947 D 5061 CDS An03g05280 84590735 join(1177142..1177312,1177432..1177528,1177769..1177900,1178011..1178209,1178532..1178636,1178723..1178834) VI 1 NT_166520.1 Title: weak similarity to hypothetical protein encoded by CG13918 - Drosophila melanogaster; uncharacterized protein 1178834 84590735 An03g05280 Aspergillus niger uncharacterized protein XP_059605890.1 1177142 D 5061 CDS An03g05290 4980518 join(1179104..1179310,1179380..1180567) VI 1 NT_166520.1 Catalytic activity: successive hydrolysis of beta-D-glucose units from the non-reducing ends of 1,3-beta-D-glucans, releasing alpha-glucose.; Function: glucanases possibly play a role in cell expansion during growth, in cell-cell fusion during mating,and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase.; Pathway: starch and sucrose metabolism.; Similarity: belongs to the hydrolases family 17.; Title: similarity to glucan 1,3-beta-glucosidase Bgl2 - Saccharomyces cerevisiae; See PMID 2509432; See PMID 10935174; uncharacterized protein 1180567 4980518 An03g05290 Aspergillus niger uncharacterized protein XP_001390410.1 1179104 D 5061 CDS An03g05300 4980519 1183307..1185019 VI 1 NT_166520.1 Catalytic activity: digallate + H2O = 2 Gallate.; Remark: tannase consists of two kinds of subunits,linked by a disulfide bond(s) with molecular weights of about 30,000 and 33,000, respectively.; Remark: the tannase gene product is translated as a single polypeptide that is cleaved by post-translational modification into two tannase subunits linked by a disulfide bond(s).; Remark: this enzyme hydrolyzes the ester bonds of tannic acid to produce gallic acid and glucose.; Title: strong similarity to precursor of tannase -Aspergillus oryzae; See PMID 8917102; uncharacterized protein 1185019 4980519 An03g05300 Aspergillus niger uncharacterized protein XP_001390411.1 1183307 D 5061 CDS An03g05310 4980520 join(1185107..1185857,1185989..1186839) VI 1 NT_166520.1 Catalytic activity: salicylate + NADH + O2 = catechol + NAD+ + H2O + CO2.; Induction: nahG of P. stutzeri is induced and expressed upon incubation with salicylate.; Pathway: phenylalanine metabolism.; Remark: in this contig there is putative a second salicylate hydroxylase in ORF 25CK.; Remark: shows also strong similarity to 6-hydroxynicotinic acid mono-oxygenase patent JP09121864-A - Pseudomonas fluorescens.; Remark: two genes, nahG and nahW, encoding two independent salicylate 1-hydroxylases have been identified in the naphthalene-degrading strain Pseudomonas stutzeri AN10.; Similarity: belongs to the tetracycline 6-hydroxylase family.; Title: similarity to salicylate hydroxylase nahW -Pseudomonas stutzeri; See PMID 10197990; uncharacterized protein 1186839 4980520 An03g05310 Aspergillus niger uncharacterized protein XP_059605891.1 1185107 D 5061 CDS An03g05320 4980521 complement(join(1186954..1187287,1187347..1188560)) VI 1 NT_166520.1 Remark: in A. parasiticus expression of the hxtA gene, encoding a hexose transporter protein, was found to be concurrent with the aflatoxin pathway cluster genes, in aflatoxin-conducive medium.; Title: strong similarity to hexose transporter hxtA - Aspergillus parasiticus; See PMID 10978525; uncharacterized protein 1188560 4980521 An03g05320 Aspergillus niger uncharacterized protein XP_001390413.1 1186954 R 5061 CDS An03g05330 4980522 join(1189318..1189435,1189493..1190099,1190155..1191421,1191478..1192026) VI 1 NT_166520.1 Catalytic activity: hydrolysis of terminal,non-reducing beta-D-glucose residues with release of beta-D-glucose.; Pathway: cyanoamino acid metabolism; starch and sucrose metabolism; flavonoids, stilbene and lignin biosynthesis.; Remark: beta-glucosidases have wide specificity for beta-D-glucosides. Some examples also hydrolyse one or more of the following: beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, and beta-D-fucosides.; Similarity: belongs to the beta-glucosidases.; Title: strong similarity to beta-glucosidase precursor BGLUC - Kluyveromyces marxianus; See PMID 2835179; uncharacterized protein 1192026 4980522 An03g05330 Aspergillus niger uncharacterized protein XP_001390414.1 1189318 D 5061 CDS An03g05340 4980523 complement(join(1192066..1192732,1192971..1193606,1193634..1193809)) VI 1 NT_166520.1 Function: MAL13 regulates the coordinate transcription of structural mal1s (maltase) and agt1 (maltose permease) genes.; Remark: MAL13 contains a Zn[2]-Cys[6] fungal-type binuclear cluster domain.; Remark: YGR288w, MAL1R, and MAL13 are synonymous names.; Title: similarity to maltose pathway regulatory protein Mal13 - Saccharomyces cerevisiae; See PMID 2278509; See PMID 2037232; uncharacterized protein 1193809 4980523 An03g05340 Aspergillus niger uncharacterized protein XP_059605892.1 1192066 R 5061 CDS An03g05360 4980525 complement(join(1194868..1195098,1195156..1195353,1195413..1195771,1195836..1196167,1196226..1196298,1196352..1196365,1196432..1196598)) VI 1 NT_166520.1 Remark: also strong similarity to N. crassa mtr gene product patent WO9521263-A1.; Remark: the gene product of the mtr locus of Neurospora crassa is required for the transport of neutral aliphatic and aromatic amino acids via the N system.; Remark: there is identity to EST SEQ ID NO:3943 from Aspergillus niger.; Title: strong similarity to neutral amino acid permease mtr - Neurospora crassa; See PMID 1838345; uncharacterized protein 1196598 4980525 An03g05360 Aspergillus niger uncharacterized protein XP_001390417.1 1194868 R 5061 CDS An03g05370 84590736 join(1197041..1197212,1197331..1197602) VI 1 NT_166520.1 hypothetical protein 1197602 84590736 An03g05370 Aspergillus niger hypothetical protein XP_059600315.1 1197041 D 5061 CDS An03g05380 4980527 complement(join(1199479..1199545,1199616..1199946,1200014..1200138,1200204..1200484)) VI 1 NT_166520.1 Catalytic activity: endohydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.; Pathway: starch and sucrose metabolism.; Remark: cellulolytic proteins form a complex of enzymes that work together to depolymerize cellulose to the soluble products cellobiose and glucose. Fundamental studies on their molecular mechanisms have been facilitated by advances in molecular biology.; Title: similarity to cellulase FI-CMCase -Aspergillus aculeatus; See PMID 2249253; See PMID 7764343; See PMID 7764982; See PMID 10664848; uncharacterized protein 1200484 4980527 An03g05380 Aspergillus niger uncharacterized protein XP_001390419.1 1199479 R 5061 CDS An03g05390 84590737 join(1200806..1200865,1200975..1201046,1201125..1201231,1201323..1201458,1201542..1202222) VI 1 NT_166520.1 hypothetical protein 1202222 84590737 An03g05390 Aspergillus niger hypothetical protein XP_059600316.1 1200806 D 5061 CDS An03g05400 84590738 join(1202820..1203047,1203125..1203260,1203350..1203475,1203609..1203724,1203879..1204104,1204204..1204245,1204331..1204545) VI 1 NT_166520.1 hypothetical protein 1204545 84590738 An03g05400 Aspergillus niger hypothetical protein XP_059600317.1 1202820 D 5061 CDS An03g05410 84590739 complement(join(1204569..1204640,1204763..1204933,1204983..1205243,1205382..1205447,1205843..1205957,1206396..1206454)) VI 1 NT_166520.1 hypothetical protein 1206454 84590739 An03g05410 Aspergillus niger hypothetical protein XP_059600318.1 1204569 R 5061 CDS An03g05420 4980531 1207622..1208506 VI 1 NT_166520.1 Remark: strong similarity to human hNmrr protein SEQ ID NO:7 patent CN1269419-A.; Remark: the homologe is a human nitrogen metabolic repression regulator protein designated hNmrr. hNmrr is isolated from the human adrenal gland.; Title: strong similarity to nitrogen metabolic repression regulator protein hNmrr from patent CN1269419-A - Homo sapiens; uncharacterized protein 1208506 4980531 An03g05420 Aspergillus niger uncharacterized protein XP_001390423.1 1207622 D 5061 CDS An03g05430 4980532 complement(join(1208762..1208939,1208996..1209342,1209423..1209779,1210016..1210465)) VI 1 NT_166520.1 Catalytic activity: s-adenosyl-l-methionine + sterigmatocystin = s-adenosyl-l-homocysteine + 7-o-methylsterigmatocystin.; Pathway: aflatoxin biosynthesis.; Remark: aflatoxins are polyketide-derived secondary metabolites produced by the fungi Aspergillus flavus and Aspergillus parasiticus. Among the catalytic steps in the aflatoxin biosynthetic pathway, the conversion of sterigmatocystin to O-methylsterigmatocystin and the conversion of dihydrosterigmatocystin to dihydro-O-methylsterigmatocystin are catalyzed by an S-adenosylmethionine-dependent O-methyltransferase.; Remark: omtA of A. parasiticus is also called omt-1.; Title: strong similarity to O-methyltransferase A omtA - Aspergillus parasiticus; See PMID 7557460; See PMID 8285664; See PMID 8434913; uncharacterized protein 1210465 4980532 An03g05430 Aspergillus niger uncharacterized protein XP_059600319.1 1208762 R 5061 CDS An03g05440 4980533 complement(join(1210648..1212228,1212278..1213042,1213090..1215332,1215379..1215572,1215621..1216624,1216672..1216963,1217025..1217374)) VI 1 NT_166520.1 Function: alb1 is required for conidial pigmentation and involved in dihydroxynaphthalene-melanin biosynthesi. in A. fumigatus.; Pathway: involved in dihydroxynaphthalene-melanin biosynthesis.; Remark: the pigmentation is important for infection in A. fumigatus.; Title: strong similarity to polyketide synthase alb1 - Aspergillus fumigatus; uncharacterized protein 1217374 4980533 An03g05440 Aspergillus niger uncharacterized protein XP_059600320.1 1210648 R 5061 CDS An03g05450 4980534 complement(join(1218125..1218376,1218425..1218605,1218824..1218867,1218954..1219188,1219331..1219450,1219553..1219802,1219868..1220152,1220207..1220801,1220880..1220966)) VI 1 NT_166520.1 Remark: ABA2 cDNA encodes a chloroplast-imported protein of 72. 5 kDa, sharing similarities with different mono-oxigenases and oxidases of bacterial origin and having an ADP-binding fold and an FAD-binding domain. ABA2 protein, produced in Escherichia coli, exhibits in vitro zeaxanthin epoxidase activity. ABA2 opens the possibility to study the regulation of ABA biosynthesis and its cellular location.; Remark: abscisic acid (ABA) is a plant hormone which plays an important role in seed development and dormancy and in plant response to environmental stresses.; Title: similarity to zeaxanthin epoxidase ABA2 -Nicotiana plumbaginifolia; See PMID 8665840; uncharacterized protein 1220966 4980534 An03g05450 Aspergillus niger uncharacterized protein XP_001390426.3 1218125 R 5061 CDS An03g05460 4980535 join(1221810..1221932,1221976..1222273,1222323..1222508,1222559..1223508) VI 1 NT_166520.1 Function: the cytochrome P450 enzymes usually act as terminal oxidases in multicomponent electron transfer chains, called P450-containing monooxygenase systems.; Pathway: involved in aflatoxin biosynthetic pathway.; Remark: the avnA gene of A. parasiticus encodes a fungal cytochrome P-450-type enzyme which is involved in the conversion of averantin to averufin in the aflatoxin biosynthetic pathway in A. parasiticus.; Similarity: shows similarity to several cytochrome P450 monooxygenases.; Title: strong similarity to cytochrome P450 monooxygenase avnA - Aspergillus parasiticus; See PMID 2250647; uncharacterized protein 1223508 4980535 An03g05460 Aspergillus niger uncharacterized protein XP_001390427.1 1221810 D 5061 CDS An03g05470 84590740 complement(join(1223785..1224159,1224234..1224449)) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein SCD69.03 - Streptomyces coelicolor; uncharacterized protein 1224449 84590740 An03g05470 Aspergillus niger uncharacterized protein XP_059600321.1 1223785 R 5061 CDS An03g05480 4980537 complement(join(1225137..1225759,1225819..1225904,1225953..1226048,1226095..1226579)) VI 1 NT_166520.1 Catalytic activity: s-adenosyl-l-methionine + sterigmatocystin = s-adenosyl-l-homocysteine + 7-o-methylsterigmatocystin.; Pathway: aflatoxin biosynthesis.; Remark: aflatoxins are polyketide-derived secondary metabolites produced by the fungi Aspergillus flavus and Aspergillus parasiticus. Among the catalytic steps in the aflatoxin biosynthetic pathway, the conversion of sterigmatocystin to O-methylsterigmatocystin and the conversion of dihydrosterigmatocystin to dihydro-O-methylsterigmatocystin are catalyzed by an S-adenosylmethionine-dependent O-methyltransferase.; Remark: omtA of A. parasiticus is also called omt-1.; Title: similarity to O-methyltransferase omtA -Aspergillus parasiticus; See PMID 7557460; See PMID 8285664; See PMID 8434913; uncharacterized protein 1226579 4980537 An03g05480 Aspergillus niger uncharacterized protein XP_001390429.1 1225137 R 5061 CDS An03g05490 4980538 complement(1226884..1228035) VI 1 NT_166520.1 Catalytic activity: 3-oxoadipate + NAD+ or NADP+ = 2-maleylacetate + NADH or NADPH.; Pathway: phenylalanine metabolism; 1,4-dichlorobenzene degradation.; Remark: cloned Rhodococcus maleylacetate reductase was able to convert 2-chloromaleylacetate, an intermediate in the degradation of dichloroaromatic compounds,relatively fast and with reductive dehalogenation to maleylacetate.; Remark: maleylacetate reductases (EC 1. 3. 1. 32) have been shown to contribute not only to the bacterial catabolism of some usual aromatic compounds like quinol or resorcinol but also to the degradation of aromatic compounds carrying unusual substituents, such as halogen atoms or nitro groups.; Similarity: belongs to the alcohol dehydrogenase IV family.; Title: strong similarity to maleylacetate reductase macA - Rhodococcus opacus; See PMID 9657989; uncharacterized protein 1228035 4980538 An03g05490 Aspergillus niger uncharacterized protein XP_001390430.1 1226884 R 5061 CDS An03g05500 84590741 complement(join(1228869..1230071,1230127..1230853,1230905..1231050)) VI 1 NT_166520.1 Remark: ORF13 A. terreu increases lovastatin or monacolin J production.; Remark: similarity to A. terreus ORF13 Zinc finger II protein patent WO200037629-A2.; Similarity: belongs to the GAL4 zinc binuclear cluster family.; Title: similarity to zinc finger II protein ORF13 from patent WO200037629-A2 - Aspergillus terreus; uncharacterized protein 1231050 84590741 An03g05500 Aspergillus niger uncharacterized protein XP_059600322.1 1228869 R 5061 CDS An03g05510 84590742 join(1231768..1232032,1232271..1232329,1232449..1232516,1232614..1232696,1232771..1232853) VI 1 NT_166520.1 hypothetical protein 1232853 84590742 An03g05510 Aspergillus niger hypothetical protein XP_059600323.1 1231768 D 5061 CDS An03g05530 4980542 complement(join(1233567..1233972,1234023..1234363)) VI 1 NT_166520.1 Catalytic activity: endohydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; can hydrolyze such linkages in beta-D-glucans that also contain 1,3-linkages.; Pathway: starch and sucrose metabolism; cellulose degradation.; Remark: strong similarity to Emericella desertoru EGIII-like cellulase patent WO9931255-A2.; Title: strong similarity to endo-beta-1,4-glucanase EGIII-like from patent WO9931255-A2 - Emericella desertoru; uncharacterized protein 1234363 4980542 An03g05530 Aspergillus niger uncharacterized protein XP_001390433.1 1233567 R 5061 CDS An03g05540 4980543 join(1235513..1235896,1235975..1236439,1236486..1236653) VI 1 NT_166520.1 Remark: a Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white.; Remark: alternative name is YKR076w.; Title: strong similarity to hypothetical protein Ecm4 - Saccharomyces cerevisiae; See PMID 9335584; uncharacterized protein 1236653 4980543 An03g05540 Aspergillus niger uncharacterized protein XP_001390434.1 1235513 D 5061 CDS An03g05550 84590743 1237817..1237972 VI 1 NT_166520.1 Title: weak similarity to hypothetical protein Rv3752c - Mycobacterium tuberculosis; uncharacterized protein 1237972 84590743 An03g05550 Aspergillus niger uncharacterized protein XP_059600324.1 1237817 D 5061 CDS An03g05560 4980545 complement(join(1238462..1238776,1238838..1239195,1239245..1239588)) VI 1 NT_166520.1 Remark: Physarum polycephalum plasmodia survive adverse conditions by transforming into encysted cells called spherules. Spherulin 4 accumulates during spherulation.; Title: strong similarity to developmentally regulated spherulin 4 - Physarum polycephalum; See PMID 2930775; uncharacterized protein 1239588 4980545 An03g05560 Aspergillus niger uncharacterized protein XP_001390436.1 1238462 R 5061 CDS An03g05570 84590744 join(1239799..1239879,1239917..1240013,1240381..1240446,1240554..1240660,1240733..1240818,1240907..1241036,1241129..1241218) VI 1 NT_166520.1 hypothetical protein 1241218 84590744 An03g05570 Aspergillus niger hypothetical protein XP_059600325.1 1239799 D 5061 CDS An03g05590 4980547 join(1242058..1242153,1242487..1242621,1242686..1242835,1242898..1243114,1243182..1243527,1243576..1243746,1243799..1244118,1244182..1244322,1244379..1244668) VI 1 NT_166520.1 Remark: the transport of uracil into the yeast S. pombe is mediated by uracil permease, a specific co-transporter encoded by the FUR4 gene.; Remark: there is a striking similarity of DAL4 to the uracil permease component encoded by FUR4.; Similarity: belongs to the uracil/allantoin permase family of the major facilitator superfamily (MFS).; Title: strong similarity to uracil transport protein fur4p - Schizosaccharomyces pombe; See PMID 9730284; uncharacterized protein 1244668 4980547 An03g05590 Aspergillus niger uncharacterized protein XP_059600326.1 1242058 D 5061 CDS An03g05600 4980548 complement(join(1245016..1245403,1245477..1246567)) VI 1 NT_166520.1 Remark: ankyrins form a connection from the actin cytoskeleton to the plasmamembrane.; Title: similarity to ankyrin G - Rattus norvegicus; See PMID 9744885; uncharacterized protein 1246567 4980548 An03g05600 Aspergillus niger uncharacterized protein XP_001390439.1 1245016 R 5061 CDS An03g05610 4980549 complement(1247855..1248586) VI 1 NT_166520.1 Title: similarity to hypothetical phage tail assembly like protein AAL21482.1 - Salmonella typhimurium; uncharacterized protein 1248586 4980549 An03g05610 Aspergillus niger uncharacterized protein XP_001390440.3 1247855 R 5061 CDS An03g05620 4980550 complement(join(1248884..1249240,1249291..1249701)) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein mll2018 - Mesorhizobium loti; uncharacterized protein 1249701 4980550 An03g05620 Aspergillus niger uncharacterized protein XP_001390441.1 1248884 R 5061 CDS An03g05630 84590745 complement(join(1251715..1251832,1251896..1252049,1252104..1252172,1252233..1252287)) VI 1 NT_166520.1 Title: similarity to hypothetical protein CAD13748.1 - Ralstonia solanacearum; uncharacterized protein 1252287 84590745 An03g05630 Aspergillus niger uncharacterized protein XP_059600327.1 1251715 R 5061 CDS An03g05640 84590746 join(1253498..1253576,1253841..1254172) VI 1 NT_166520.1 hypothetical protein 1254172 84590746 An03g05640 Aspergillus niger hypothetical protein XP_059600328.1 1253498 D 5061 CDS An03g05650 4980553 complement(join(1255705..1256293,1256396..1256484,1256559..1256901,1256957..1257345,1257421..1257574,1257615..1257911,1257975..1258045)) VI 1 NT_166520.1 Similarity: the ORF shows weak similarity to another A. niger protein. The similarity between the two protein is restricted to a stretch of about 300 amino acids.; Title: weak similarity to hypothetical protein encoded by An04g00590 - Aspergillus niger; uncharacterized protein 1258045 4980553 An03g05650 Aspergillus niger uncharacterized protein XP_059600329.1 1255705 R 5061 CDS An03g05660 4980554 complement(join(1260364..1260839,1260978..1261062,1261139..1261558,1261642..1261734,1261817..1262051,1262124..1262253,1262301..1262331)) VI 1 NT_166520.1 Catalytic activity: 2 H(2)O(2) <=> O(2) + 2 H(2)O.; Cofactor: Heme; Manganese.; Remark: This enzyme can also act as a peroxidase (EC 1. 11. 1. 7) for which several organic substances,especially ethanol, can act as a hydrogen donor. A manganese protein containing Mn(III) in the resting state,which also belongs here, is often called pseudocatalase. Enzymes from some microorganisms, such as Penicillium simplicissimum, which exhibit both catalase and peroxidase activity, have sometimes been referred to as catalase-peroxidase.; Title: strong similarity to catalase C catC -Aspergillus nidulans; See PMID 11157957; uncharacterized protein 1262331 4980554 An03g05660 Aspergillus niger uncharacterized protein XP_001390445.1 1260364 R 5061 CDS An03g05670 4980555 join(1263354..1264890,1264950..1265113,1265175..1265255) VI 1 NT_166520.1 Alternative name: Veratryl alcohol oxidase.; Catalytic activity: An aromatic primary alcohol + O(2) <=> an aromatic aldehyde + H(2)O(2); Remark: Oxidizes many primary alcohols containing an aromatic ring; best substrates are (2-naphthyl)-methanol and 3-methoxybenzyl alcohol.; Title: strong similarity to aryl-alcohol oxidase precursor aao - Pleurotus pulmonarius; See PMID 10606774; uncharacterized protein 1265255 4980555 An03g05670 Aspergillus niger uncharacterized protein XP_001390446.1 1263354 D 5061 CDS An03g05680 4980556 complement(1265470..1268490) VI 1 NT_166520.1 Remark: the peptide synthetase mps is involved in the biosynthesis of glycopeptidolipids of Mycobacterium smegmatis.; Title: strong similarity to peptide synthase mps -Mycobacterium smegmatis; See PMID 10510238; uncharacterized protein 1268490 4980556 An03g05680 Aspergillus niger uncharacterized protein XP_001390447.1 1265470 R 5061 CDS An03g05690 84590747 1269908..1271524 VI 1 NT_166520.1 Similarity: the ORF shows weak similarity to another A. niger protein: An03g05700. The similarity between the two proteins is restricted to a stretch of about 250 amino acids.; Title: weak similarity to hypothetical protein encoded by An03g05700 - Aspergillus niger; uncharacterized protein 1271524 84590747 An03g05690 Aspergillus niger uncharacterized protein XP_059600330.1 1269908 D 5061 CDS An03g05700 84590748 join(1272833..1272885,1273254..1273727,1273771..1274416) VI 1 NT_166520.1 Similarity: the ORF shows weak similarity to another A. niger protein. The similarity between the two proteins,however, is restricted to a stretch of about 200 amino acids.; Title: weak similarity to hypothetical protein encoded by An03g05690 - Aspergillus niger; uncharacterized protein 1274416 84590748 An03g05700 Aspergillus niger uncharacterized protein XP_059600331.1 1272833 D 5061 CDS An03g05710 84590749 complement(join(1275076..1275602,1275661..1277071)) VI 1 NT_166520.1 Similarity: the similarity to CipA from Clostridium thermocellum is located in an highly repetetive sequence domain of CipA.; Title: similarity to S-layer protein CipA -Clostridium thermocellum; See PMID 8458832; uncharacterized protein 1277071 84590749 An03g05710 Aspergillus niger uncharacterized protein XP_059600332.1 1275076 R 5061 CDS An03g05720 4980560 join(1278055..1278094,1278193..1278752,1278821..1278865,1278969..1279038,1279091..1279395,1279525..1279631,1279688..1279892,1279955..1280084,1280135..1280343) VI 1 NT_166520.1 Title: weak similarity to dnaK-type molecular chaperone HSP71.2 - Pisum sativum; See PMID 9207851; uncharacterized protein 1280343 4980560 An03g05720 Aspergillus niger uncharacterized protein XP_059600333.1 1278055 D 5061 CDS An03g05730 84590750 complement(join(1280498..1280535,1280619..1280751,1280965..1281027,1281286..1281410,1281493..1281508)) VI 1 NT_166520.1 hypothetical protein 1281508 84590750 An03g05730 Aspergillus niger hypothetical protein XP_059600334.1 1280498 R 5061 CDS An03g05740 4980562 join(1282949..1284257,1284459..1284976) VI 1 NT_166520.1 Similarity: similarity to cellulose synthase Y16099 Patentprot.; Title: similarity to cellulose synthase protein from patent JP11127867-A - Acetobacter xylinum; uncharacterized protein 1284976 4980562 An03g05740 Aspergillus niger uncharacterized protein XP_059600335.1 1282949 D 5061 CDS An03g05750 4980563 complement(join(1285418..1286622,1286676..1286791,1286845..1287095)) VI 1 NT_166520.1 Function: the S. cerevisiae FLR1 gene product probable efflux transporter and confers resistance to the azole derivative fluconazole (FCZ).; Similarity: the S. cerevisiae FLR1 belongs to the major facilitator family (also known as the drug resistance translocasefamily), DHA14 subfamily.; Title: strong similarity to fluconazole resistance transporter Flr1 - Saccharomyces cerevisiae; See PMID 9235926; See PMID 10572257; uncharacterized protein 1287095 4980563 An03g05750 Aspergillus niger uncharacterized protein XP_001390454.1 1285418 R 5061 CDS An03g05760 84590751 join(1287649..1288291,1288546..1288634) VI 1 NT_166520.1 Catalytic activity: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.; Function: the mam4 gene product modifies mating pheromone M-factor in h-cells modifies mating pheromone M-factor in h-cells.; Remark: mam4 mutation of S. pombe causes mating deficiency, the mam4 gene product shows methyltransferase activity.; Title: weak similarity to protein-S-isoprenylcysteine O-methyltransferase mam4p -Schizosaccharomyces pombe; See PMID 9032282; uncharacterized protein 1288634 84590751 An03g05760 Aspergillus niger uncharacterized protein XP_059600336.1 1287649 D 5061 CDS An03g05770 4980565 join(1289823..1290081,1290158..1290870) VI 1 NT_166520.1 Title: similarity to Plasma membrane aquaporin 2b PAQ2b - Raphanus sativus; plasma membrane; See PMID 11216851; uncharacterized protein 1290870 4980565 An03g05770 Aspergillus niger uncharacterized protein XP_059600337.1 1289823 D 5061 CDS An03g05780 4980566 complement(1291158..1292894) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein SCF91.02c - Streptomyces coelicolor; uncharacterized protein 1292894 4980566 An03g05780 Aspergillus niger uncharacterized protein XP_001390457.3 1291158 R 5061 CDS An03g05790 4980567 complement(join(1293452..1293765,1293814..1294274,1294323..1294446,1294493..1294619,1294675..1294803)) VI 1 NT_166520.1 Function: the A. parasiticus O-methyltransferase catalyzes the conversions of demethylsterigmatocystin to sterigmatocystin and dihydrodemethylsterigmatocystin to dihydrosterigmatocystin.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Remark: biosynthesis of aflatoxins (B(1), G(1), B(2), and G(2)) in A. parasiticus is a multi-enzyme process controlled genetically by over 20 genes.; Title: strong similarity to O-methyltransferase B omtB - Aspergillus parasiticus; See PMID 10806361; uncharacterized protein 1294803 4980567 An03g05790 Aspergillus niger uncharacterized protein XP_001390458.3 1293452 R 5061 CDS An03g05800 84590752 join(1295138..1295174,1295231..1295385) VI 1 NT_166520.1 hypothetical protein 1295385 84590752 An03g05800 Aspergillus niger hypothetical protein XP_059600338.1 1295138 D 5061 CDS An03g05810 4980569 join(1296569..1296739,1296784..1297168,1297202..1297331,1297377..1297444,1297491..1297521,1297562..1297913) VI 1 NT_166520.1 Function: the product of M. grisea pathogenicity gene pth11 is not required for appressorium morphogenesis but is involved in host surface recognition.; Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529; uncharacterized protein 1297913 4980569 An03g05810 Aspergillus niger uncharacterized protein XP_059600339.1 1296569 D 5061 CDS An03g05820 84590753 join(1298632..1298730,1298812..1298970) VI 1 NT_166520.1 hypothetical protein 1298970 84590753 An03g05820 Aspergillus niger hypothetical protein XP_059600340.1 1298632 D 5061 CDS An03g05830 4980571 complement(join(1299025..1299252,1299326..1299430,1299488..1300183,1300253..1300324,1300371..1300715,1300834..1300938)) VI 1 NT_166520.1 Remark: HOL1-1 single mutants show hypersensitivity to specific cations added to the growth medium, including Na+, Li+, Cs+, Be2+, guanidinium ion, and histidinol, but not K+, Rb+, Ca2+, or Mg2+.; Remark: mutations in the S. cerevisiae hol1 gene permit growth of His- cells on histidinol by enhancing the ability of cells to take up histidinol from the medium.; Title: strong similarity to multidrug resistance protein Hol1 - Saccharomyces cerevisiae; plasma membrane; See PMID 8955402; See PMID 2405251; uncharacterized protein 1300938 4980571 An03g05830 Aspergillus niger uncharacterized protein XP_059600341.1 1299025 R 5061 CDS An03g05840 4980572 join(1301708..1301750,1301808..1302241,1302300..1302626) VI 1 NT_166520.1 Title: similarity to hypothetical puromycin N-acetyltransferase - Streptomyces lipmanii; uncharacterized protein 1302626 4980572 An03g05840 Aspergillus niger uncharacterized protein XP_001390463.1 1301708 D 5061 CDS An03g05850 4980573 complement(join(1303418..1303464,1303572..1303805,1303861..1303929,1303986..1304264,1304341..1304347)) VI 1 NT_166520.1 Remark: ARG81 of S. cerevisiae is also known as ARGR2 (ARGRII) and has a systematic name of YML099C.; Title: weak similarity to hypothetical transcription factor Arg81 - Saccharomyces cerevisiae; See PMID 10688655; uncharacterized protein 1304347 4980573 An03g05850 Aspergillus niger uncharacterized protein XP_059600342.1 1303418 R 5061 CDS An03g05860 4980574 join(1304713..1304903,1304956..1306417) VI 1 NT_166520.1 Function: the B. subtilis PNB carboxy-esterase (PNBCE) catalyzes hydrolysis of several beta-lactam antibiotic PNB esters to the corresponding free acid and PNB alcohol.; Title: strong similarity to p-nitrobenzyl esterase pnbA - Bacillus subtilis; See PMID 7828905; uncharacterized protein 1306417 4980574 An03g05860 Aspergillus niger uncharacterized protein XP_001390465.1 1304713 D 5061 CDS An03g05870 4980575 complement(1306545..1308095) VI 1 NT_166520.1 Title: similarity to hypothetical oxidoreductase PA5309 - Pseudomonas aeruginosa; uncharacterized protein 1308095 4980575 An03g05870 Aspergillus niger uncharacterized protein XP_001390466.1 1306545 R 5061 CDS An03g05880 4980576 join(1309684..1309999,1310083..1310331,1310389..1311272,1311333..1311420,1311490..1311602) VI 1 NT_166520.1 Catalytic activity: a Monocarboxylic acid amide + H2O = a Monocarboxylate + NH3.; Function: the A. oryzae amds gene product is required for utilization of acetamide or acetate plus beta-alanine as the sole carbon and nitrogen sources.; Title: strong similarity to acetamidase amdS -Aspergillus oryzae; See PMID 10490592; See PMID 1840550; uncharacterized protein 1311602 4980576 An03g05880 Aspergillus niger uncharacterized protein XP_059600343.1 1309684 D 5061 CDS An03g05890 4980577 complement(join(1311964..1312196,1312246..1312359,1312413..1312602,1312656..1312756,1312805..1313078,1313123..1313262,1313312..1313378,1313424..1313539,1313589..1313838)) VI 1 NT_166520.1 Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 9090059; See PMID 10869563; uncharacterized protein 1313838 4980577 An03g05890 Aspergillus niger uncharacterized protein XP_001390468.1 1311964 R 5061 CDS An03g05900 84590754 join(1315156..1315242,1315301..1315717,1315783..1316295,1316466..1316668,1316717..1317064,1317113..1317686) VI 1 NT_166520.1 Remark: nit-4, a pathway-specific regulatory gene in the nitrogen circuit of Neurospora crassa, is required for the expression of nit-3 and nit-6, the structural genes which encode nitrate and nitrite reductase, respectively.; Remark: there is another homologous regulatory gene from Aspergillus nidulans, nirA, which encodes a protein whose amino-terminal half has approximately 60% amino acid identity with NIT4 but whose carboxy terminus is completely different.; Title: similarity to nitrogen assimilation regulatory protein nit-4 - Neurospora crassa; nucleus; See PMID 1840634; See PMID 1922075; uncharacterized protein 1317686 84590754 An03g05900 Aspergillus niger uncharacterized protein XP_059600344.1 1315156 D 5061 CDS An03g05910 4980579 complement(join(1318007..1318772,1318838..1318992)) VI 1 NT_166520.1 Catalytic activity: Thiosulfate + Hydrogen cyanide = Sulfite + Thiocyanate.; Function: rhodanese is a detoxification enzyme for cyanide.; Title: strong similarity to hepatic rhodanese -Gallus gallus; See PMID 1953758; See PMID 2275748; uncharacterized protein 1318992 4980579 An03g05910 Aspergillus niger uncharacterized protein XP_001390470.3 1318007 R 5061 CDS An03g05930 4980581 join(1320669..1321268,1321329..1322051) VI 1 NT_166520.1 Catalytic activity: acid phosphatases convert an orthophosphoric monoester + H2O <=> an alcohol + phosphate,but in addition catalyses transphosphorylations.; Remark: the acid phosphatase pho is also called orthophosphoric-monoester phosphohydrolase with acid optimum.; Similarity: the predicted ORF shows strong similarity to 3-phytase phyA of A. niger.; Title: strong similarity to acid phosphatase pho -Pichia pastoris; See PMID 7557473; uncharacterized protein 1322051 4980581 An03g05930 Aspergillus niger uncharacterized protein XP_001390471.1 1320669 D 5061 CDS An03g05940 4980582 complement(join(1322334..1322716,1322781..1324198,1324259..1324490,1324548..1324618,1324674..1324678)) VI 1 NT_166520.1 Catalytic activity: gfa1 of S. cerevisiae catalyzes the formation of D-glucosamine-6-phosphate from the amido group of L-glutamine and fructose-6-phosphate: L-glutamine + D-fructose-6-phosphate <=> L-glutamate + D-glucosamine-6-phosphate.; Function: gfa1 of S. cerevisiae is involved in the first step of the hexosamine pathway required for biosynthesis of cell wall precursors.; Induction: the glutamine--fructose-6-phosphate amidotransferase activity of gfa1 from S. cerevisiae increases 1. 7-fold after alpha factor addition.; Induction: the promotor region of the S. cerevisiae gfa1 gene contains six repeats of the heptanucleotide TGAAACA, which was shown to be required for pheromone control of transcription.; Remark: glucosamine-6-phosphate is used in the biosynthesis of amino sugars of asparagine-linked oligosaccharide chains in glycoproteins.; Title: strong similarity to glutamine-fructose-6-phosphate transaminase Gfa1 -Saccharomyces cerevisiae; cytoplasm; See PMID 3301002; uncharacterized protein 1324678 4980582 An03g05940 Aspergillus niger uncharacterized protein XP_001390472.1 1322334 R 5061 CDS An03g05950 4980583 complement(join(1325486..1325700,1325766..1325861,1325917..1325984,1326036..1326242,1326299..1326376,1326433..1326608,1326660..1326854,1326900..1327063,1327116..1327158,1327222..1327503)) VI 1 NT_166520.1 Function: the liz1 of S. pombe is a putative allantoate permease involved in ribonucleotide reductase activity during mitosis.; Phenotype: inactivation of ribonucleotide reductase causes liz1(-) cells in G2 to undergo an aberrant mitosis,resulting in chromosome missegregation and late mitotic arrest.; Title: strong similarity to transmembrane transporter liz1p - Schizosaccharomyces pombe; See PMID 9950674; uncharacterized protein 1327503 4980583 An03g05950 Aspergillus niger uncharacterized protein XP_001390473.1 1325486 R 5061 CDS An03g05960 4980584 complement(1328170..1329030) VI 1 NT_166520.1 Catalytic activity: cEH of C. sp. acts on epoxides (alkene oxides, oxiranes) and arene oxides by converting an epoxide + H2O = a glycol.; Function: the cytosolic epoxide hydrolase cEH of C. sp. is involved in the catabolic degradation of epoxides.; Induction: cEH of C. sp is expressed constitutively at a low level, but can be induced by cyclohexane oxide and (+/-)-trans-1,2-dihydroxycyclohexane.; Title: strong similarity to epoxide hydrolase cEH -Corynebacterium sp.; See PMID 9578475; uncharacterized protein 1329030 4980584 An03g05960 Aspergillus niger uncharacterized protein XP_001390474.1 1328170 R 5061 CDS An03g05970 84590755 complement(join(1329719..1329886,1329978..1330108,1330196..1330232)) VI 1 NT_166520.1 hypothetical protein 1330232 84590755 An03g05970 Aspergillus niger hypothetical protein XP_059600345.1 1329719 R 5061 CDS An03g05980 4980586 join(1330549..1330634,1330731..1331362,1331427..1332253,1332303..1332818) VI 1 NT_166520.1 Function: facB of A. niger is a major regulatory gene involved in acetamide and acetate utilisation.; Function: the acetate regulatory gene facB of A. niger encodes a Zn(II)2-Cys6 transcriptional activator.; Phenotype: deletion of the facB gene of A. nidulans confirmed that it is required for growth on acetate as a sole carbon source.; Similarity: the 180 C-terminal amino acids of the predicted ORF are not significantly homologues to the facB of A. niger.; Title: strong similarity to acetate regulatory DNA binding protein facB - Aspergillus niger; nucleus; See PMID 9197408; uncharacterized protein 1332818 4980586 An03g05980 Aspergillus niger uncharacterized protein XP_059600346.1 1330549 D 5061 CDS An03g05990 4980587 complement(join(1333367..1333701,1333768..1334207,1334286..1334409,1334459..1334813)) VI 1 NT_166520.1 Function: A. parasiticus dmtA is an O-methyltransferase involved in aflatoxin biosynthesis.; Function: A. parasiticus dmtA is involved in the conversion of demethylsterigmatocystin (DMST) to sterigmatocystin (ST) and dihydrodemethylsterigmatocystin (DHDMST) to dihydrosterigmatocystin (DHST).; Remark: aflatoxins are polyketide-derived secondary metabolites.; Remark: an alternative name for A. parasiticus dmtA is omtB.; Title: strong similarity to O-methyltransferase B omtB - Aspergillus parasiticus; See PMID 10543813; See PMID 10806361; uncharacterized protein 1334813 4980587 An03g05990 Aspergillus niger uncharacterized protein XP_059600347.1 1333367 R 5061 CDS An03g06000 4980588 complement(join(1335428..1336729,1336810..1336926)) VI 1 NT_166520.1 Catalytic activity: (R)-6-hydroxynicotine oxidases convert (R)-6-hydroxynicotine + H(2)O + O(2) to 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H(2)O(2).; Complex: A. oxidans 6-HDNO is a flavoprotein.; Function: A. oxidans 6-HDNO is involved in nicotine catabolism.; Similarity: similarity is between the N-terminal halfs of the predicted A. niger protein and A. oxidans 6-HDNO. .; Title: similarity to 6-Hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 3622516; uncharacterized protein 1336926 4980588 An03g06000 Aspergillus niger uncharacterized protein XP_001390478.1 1335428 R 5061 CDS An03g06010 84590756 join(1337822..1341766,1341930..1342089,1342780..1342987,1343023..1345702) VI 1 NT_166520.1 Function: A. alternata AMT is required to produce the cyclic peptide host-specific toxin, AM-toxin.; Similarity: similarity is from all of the predicted A. niger protein to all of A. alternata AMT, which is twice as long.; Title: strong similarity to cyclic peptide AM-toxin synthase AMT - Alternaria alternata; See PMID 10875335; uncharacterized protein 1345702 84590756 An03g06010 Aspergillus niger uncharacterized protein XP_059600348.1 1337822 D 5061 CDS An03g06020 4980590 join(1346778..1346994,1347045..1347256) VI 1 NT_166520.1 Catalytic activity: 4-carboxymuconolactone decarboxylase convert 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate to 4,5-dihydro-5-oxofuran-2-acetate + CO(2).; Function: A. calcoaceticus pcaC is involved in 3,4-dihydroxybenzoate-O(,2)-acetyl-Co A-succinate catabolism; Title: strong similarity to 4-carboxymuconolactone decarboxylase pcaC - Acinetobacter calcoaceticus; uncharacterized protein 1347256 4980590 An03g06020 Aspergillus niger uncharacterized protein XP_001390480.1 1346778 D 5061 CDS An03g06030 84590757 complement(join(1352100..1352324,1352383..1352475,1352593..1352697)) VI 1 NT_166520.1 Title: weak similarity to flt-3 receptor agonist pMON32323.pep from patent WO9818923-A1 - Homo sapiens; uncharacterized protein 1352697 84590757 An03g06030 Aspergillus niger uncharacterized protein XP_059600349.1 1352100 R 5061 CDS An03g06040 84590758 join(1353286..1353436,1353481..1353565,1353641..1353806,1353857..1354007,1354125..1354372) VI 1 NT_166520.1 Title: weak similarity to hypothetical protein T3F20.24 - Arabidopsis thaliana; uncharacterized protein 1354372 84590758 An03g06040 Aspergillus niger uncharacterized protein XP_059600350.1 1353286 D 5061 CDS An03g06060 84590759 complement(join(1354905..1355064,1355318..1355513,1355639..1355724,1355779..1355804,1355934..1356036,1356141..1356223)) VI 1 NT_166520.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1356223 84590759 An03g06060 Aspergillus niger uncharacterized protein XP_059600351.1 1354905 R 5061 CDS An03g06070 84590760 complement(join(1357599..1357650,1357777..1358198)) VI 1 NT_166520.1 hypothetical protein 1358198 84590760 An03g06070 Aspergillus niger hypothetical protein XP_059600352.1 1357599 R 5061 CDS An03g06080 4980596 complement(join(1359523..1359708,1359902..1360052,1360102..1360796,1360843..1360911)) VI 1 NT_166520.1 Function: S. cerevisiae UPC2 is a binucleate zinc cluster protein controlling expression of an anaerobic sterol transport system and DAN/TIR mannoproteins.; Induction: expression of S. cerevisiae UPC2 is induced both in anaerobic and cold-shocked cells.; Remark: the systematic name for S. cerevisiae UPC2 is YDR213w, an alternative name is MOX4.; Title: similarity to transcription activator Upc2 -Saccharomyces cerevisiae; nucleus; See PMID 11238402; uncharacterized protein 1360911 4980596 An03g06080 Aspergillus niger uncharacterized protein XP_001390485.3 1359523 R 5061 CDS An03g06090 4980597 join(1361399..1361563,1361794..1362043,1362095..1362558) VI 1 NT_166520.1 Function: overexpression of S. cerevisiae RTM1 confers resistance to the toxicity of molasses.; Remark: S. cerevisiae RTM1 is present in multiple copies and in variable locations in the genome and is always physically associated with SUC telomeric loci.; Title: strong similarity to molasses resistency protein Rtm1 - Saccharomyces cerevisiae; See PMID 7672593; uncharacterized protein 1362558 4980597 An03g06090 Aspergillus niger uncharacterized protein XP_059600353.1 1361399 D 5061 CDS An03g06100 84590761 complement(join(1365508..1365592,1365767..1365795,1365867..1365923,1366096..>1366230)) VI 1 NT_166520.1 Remark: ORF 5'truncated due to end of contig.; hypothetical protein [truncated ORF] 1366230 84590761 An03g06100 Aspergillus niger hypothetical protein [truncated ORF] XP_059600354.1 1365508 R 5061 CDS An03g06110 84590762 join(1366537..1366734,1366818..1367214,1367300..1367544) VI 1 NT_166520.1 hypothetical protein 1367544 84590762 An03g06110 Aspergillus niger hypothetical protein XP_059600355.1 1366537 D 5061 CDS An03g06120 4980600 join(1367909..1368845,1368877..1369512,1369568..1370097) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein CAD21096.1 - Neurospora crassa; uncharacterized protein 1370097 4980600 An03g06120 Aspergillus niger uncharacterized protein XP_059600356.1 1367909 D 5061 CDS An03g06130 84590763 1370186..1371832 VI 1 NT_166520.1 Function: kinesins are ATPases specifically moving in the direction of the positive or negative end of microtubuli.; Title: strong similarity to kinesin light chain KLC - Plectonema boryanum; cytoskeleton; See PMID 9212172; See PMID 10754574; See PMID 11212346; uncharacterized protein 1371832 84590763 An03g06130 Aspergillus niger uncharacterized protein XP_059600357.1 1370186 D 5061 CDS An03g06140 4980602 complement(join(1373233..1373626,1373678..1373708,1373761..1373786,1373846..1373964,1374022..1374057,1374108..1374156,1374259..1374312,1374377..1374411,1374534..1374701,1374865..1374909,1374995..1375033,1375256..1375600)) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein encoded by 123A4.300 - Neurospora crassa; uncharacterized protein 1375600 4980602 An03g06140 Aspergillus niger uncharacterized protein XP_059600358.1 1373233 R 5061 CDS An03g06160 84590764 complement(join(1375978..1376058,1376149..1376223)) VI 1 NT_166520.1 Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1376223 84590764 An03g06160 Aspergillus niger uncharacterized protein XP_059600359.1 1375978 R 5061 CDS An03g06175 84590765 join(1376933..1377038,1377091..1377140,1377233..1377433) VI 1 NT_166520.1 hypothetical protein 1377433 84590765 An03g06175 Aspergillus niger hypothetical protein XP_059600360.1 1376933 D 5061 CDS An03g06180 84590766 join(1377719..1377787,1378004..1378034,1378131..1378372) VI 1 NT_166520.1 hypothetical protein 1378372 84590766 An03g06180 Aspergillus niger hypothetical protein XP_059600361.1 1377719 D 5061 CDS An03g06200 84590767 complement(join(1380144..1380300,1380587..1380870,1381022..1381154,1381262..1381377)) VI 1 NT_166520.1 hypothetical protein 1381377 84590767 An03g06200 Aspergillus niger hypothetical protein XP_059600362.1 1380144 R 5061 CDS An03g06210 4980608 join(1384221..1384347,1384401..1384472,1384557..1384663) VI 1 NT_166520.1 Remark: the ORF also shows strong similarity to EST an_1824 of A. niger.; Title: similarity to hypothetical protein YGR273c -Saccharomyces cerevisiae; uncharacterized protein 1384663 4980608 An03g06210 Aspergillus niger uncharacterized protein XP_001390496.1 1384221 D 5061 CDS An03g06220 4980609 join(1384810..1385191,1385744..1386493,1386557..1387281) VI 1 NT_166520.1 Similarity: the ORF encoded protein and Gel1p of A. fumigatus show similarity to the Gas/Phr/Epd protein families, which are involved in yeast morphogenesis.; Title: strong similarity to glycosylphosphatidylinositol-anchored beta(1-3)glucanosyltransferase gel3 - Aspergillus fumigatus; See PMID 10769178; uncharacterized protein 1387281 4980609 An03g06220 Aspergillus niger uncharacterized protein XP_059600363.1 1384810 D 5061 CDS An03g06230 4980610 join(1388526..1388912,1388966..1390660) VI 1 NT_166520.1 Similarity: belongs to the GAL4 zinc binuclear cluster family.; Similarity: the ORF shows similarity to various transcription factors.; Title: strong similarity to hypothetical transcription activator SPAC139.03 - Schizosaccharomyces pombe; uncharacterized protein 1390660 4980610 An03g06230 Aspergillus niger uncharacterized protein XP_001390498.3 1388526 D 5061 CDS An03g06240 4980611 complement(join(1391746..1391868,1392134..1392343,1392388..1392538,1392610..1392795,1392871..1393717,1393787..1393962,1394045..1394075,1394139..1394259,1394315..1394387,1394461..1394571,1394638..1395245,1395339..1395587)) VI 1 NT_166520.1 Remark: in fission yeast the protein has the following recognisable motifs present: a nuclear localization signal, a RING finger and helicase domains.; Similarity: belongs to the SNF2 protein family.; Title: strong similarity to DNA repair protein rad8p - Schizosaccharomyces pombe; See PMID 8290359; uncharacterized protein 1395587 4980611 An03g06240 Aspergillus niger uncharacterized protein XP_059600364.1 1391746 R 5061 CDS An03g06250 4980612 join(1395895..1396384,1396447..1397382,1397501..1397558,1397622..1397888,1397962..1398407,1398485..1399734) VI 1 NT_166520.1 Remark: contrary to other members of the beta-transducin family, sequence conservation between the repeated units in het-e1 in Podospora anserina is very strong and the number of repeats is different in wild-type het-e alleles.; Title: similarity to beta transducin-like protein het-e1 - Podospora anserina; See PMID 7557402; uncharacterized protein 1399734 4980612 An03g06250 Aspergillus niger uncharacterized protein XP_059600365.1 1395895 D 5061 CDS An03g06260 84590768 join(1400107..1400157,1400227..1400419,1400467..1400558) VI 1 NT_166520.1 hypothetical protein 1400558 84590768 An03g06260 Aspergillus niger hypothetical protein XP_059600366.1 1400107 D 5061 CDS An03g06270 4980614 complement(join(1401565..1403002,1403058..1403317)) VI 1 NT_166520.1 Title: strong similarity to isoamyl alcohol oxidase mreA - Aspergillus oryzae; uncharacterized protein 1403317 4980614 An03g06270 Aspergillus niger uncharacterized protein XP_001390502.1 1401565 R 5061 CDS An03g06280 4980615 join(1404165..1404378,1404428..1404495,1404555..1404740,1404901..1405048,1405214..1405260,1405327..1405755) VI 1 NT_166520.1 Remark: PTH11 from Magnaporthe grisea is about 300 amino acids longer.; Title: weak similarity to integral membrane protein PTH11 from patent WO9913094-A2 - Magnaporthe grisea; uncharacterized protein 1405755 4980615 An03g06280 Aspergillus niger uncharacterized protein XP_059600367.1 1404165 D 5061 CDS An03g06290 84590769 join(1407338..1407496,1407623..1407989,1408102..1408241) VI 1 NT_166520.1 Similarity: the ORF shows over a stretch of about 100 amino acids similarity to another A. niger protein,An11g08920.; Title: weak similarity to hypothetical protein encoded by An11g08920 - Aspergillus niger; uncharacterized protein 1408241 84590769 An03g06290 Aspergillus niger uncharacterized protein XP_059600368.1 1407338 D 5061 CDS An03g06300 4980617 complement(1409627..1411006) VI 1 NT_166520.1 Remark: the protein seems 80 amino acids too long.; Title: similarity to hypothetical protein Rv0272c -Mycobacterium tuberculosis; uncharacterized protein 1411006 4980617 An03g06300 Aspergillus niger uncharacterized protein XP_001390505.1 1409627 R 5061 CDS An03g06310 4980618 join(1415764..1415880,1415942..1416078,1416129..1416208,1416260..1416406,1416458..1416518,1416575..1416768,1416830..1417089) VI 1 NT_166520.1 Catalytic activity: pectin + n H2O = n methanol + pectate.; Gene-ID: pmeA; Pathway: pentose and glucuronate interconversions; starch and sucrose metabolism.; Remark: on the basis of the results of affinity labeling of PME with sugar-specific lectins and the amino acid sequence data, it has been revealed that PME is a glycoprotein and the protein-bound glycans are oligosaccharides with a high mannose content.; Remark: the differences in the sequence are caused by strain variations or sequencing errors.; Remark: this enzyme belongs to the group of pectic enzymes and catalyzes the hydrolysis of methyl ester groups of galactaronic acid residues of pectin.; See PMID 1937044; See PMID 2089377; pectinesterase pmeA-Aspergillus niger 1417089 pmeA 4980618 pmeA Aspergillus niger pectinesterase pmeA-Aspergillus niger XP_001390506.1 1415764 D 5061 CDS An03g06320 4980619 complement(join(1417478..1417776,1417854..1418223,1418340..1418465)) VI 1 NT_166520.1 Remark: Rhodococcus erythropolis TA421, a polychlorinated biphenyl and biphenyl degrader isolated from a termite ecosystem, has seven bphC genes expressing 2, 3-dihydroxybiphenyl dioxygenase activity.; Title: strong similarity to 2-hydroxyhepta-2,4-diene-1,7-dioateisomerase/5-carboxymeth yl-2-oxo-hex-3-ene-1,7-dioatedecarboxylase - Rhodobacter capsulatus; See PMID 9251216; uncharacterized protein 1418465 4980619 An03g06320 Aspergillus niger uncharacterized protein XP_059600369.1 1417478 R 5061 CDS An03g06330 4980620 complement(join(1418905..1419384,1419435..1419666,1419721..1419868,1419917..1420094,1420146..1420166)) VI 1 NT_166520.1 Remark: the enzyme from Pseudomonas stutzeri catalyzes the extradiol ring cleavage of 2,3-dihydroxybiphenyl as a key enzyme in the biphenyl/PCB degradation pathway.; Title: strong similarity to 2,3-dihydroxybiphenyl-1,2-dioxygenase bphC - Pseudomonas stutzeri; See PMID 9095556; uncharacterized protein 1420166 4980620 An03g06330 Aspergillus niger uncharacterized protein XP_001390508.1 1418905 R 5061 CDS An03g06340 4980621 1421400..1421897 VI 1 NT_166520.1 Similarity: the similarity between the two A. niger proteins is restricted to a stretch of about 90 amino acids.; Title: weak similarity to hypothetical protein encoded by An02g01320 - Aspergillus niger; uncharacterized protein 1421897 4980621 An03g06340 Aspergillus niger uncharacterized protein XP_001390509.1 1421400 D 5061 CDS An03g06350 4980622 complement(join(1422026..1422122,1422199..1422227,1422276..1422925,1422966..1423032,1423089..1423199,1423256..1423432)) VI 1 NT_166520.1 Title: weak similarity to hypothetical protein YLR392c - Saccharomyces cerevisiae; uncharacterized protein 1423432 4980622 An03g06350 Aspergillus niger uncharacterized protein XP_059600370.1 1422026 R 5061 CDS An03g06360 4980623 join(1424106..1424195,1424248..1424608,1424662..1425023,1425090..1425753,1425808..1425990,1426036..1426219,1426267..1426906,1426964..1427101) VI 1 NT_166520.1 Catalytic activity: UDP-N-acetyl-D-glucosamine + [1,4-(N-Acetyl-beta-D-glucosaminyl)]n = UDP + [1,4-(N-Acetyl-beta-D-glucosaminyl)]n+1.; Pathway: aminosugars metabolism.; Remark: chsC Aspergillus fumigatus is a Class III zymogen-type enzyme.; Title: strong similarity to chitin synthase C chsC -Aspergillus fumigatus; See PMID 8736545; uncharacterized protein 1427101 4980623 An03g06360 Aspergillus niger uncharacterized protein XP_001390511.3 1424106 D 5061 CDS An03g06370 4980624 join(1427874..1428366,1428516..1428832,1428886..1429302,1429361..1429587,1429680..1429818,1429901..1430128) VI 1 NT_166520.1 Title: weak similarity to transcription activator Cha4 - Saccharomyces cerevisiae; uncharacterized protein 1430128 4980624 An03g06370 Aspergillus niger uncharacterized protein XP_059600371.1 1427874 D 5061 CDS An03g06380 4980625 join(1431197..1431229,1431358..1432046,1432136..1432649,1432710..1432833,1432887..1432999,1433063..1433495,1433551..1433997,1434045..1436300,1436351..1436376,1436455..1437588,1437641..1437715,1437763..1438103,1438163..1438593,1438645..1439591) VI 1 NT_166520.1 Remark: FUM5 from Gibberella fujikuroi is a PKS gene required for fumonisin biosynthesis.; Remark: polyketide natural products show great promise as medicinal agents. Typically the products of microbial secondary biosynthesis, polyketides are synthesized by an evolutionarily related but architecturally diverse family of multifunctional enzymes called polyketide synthases.; Title: strong similarity to polyketide synthase FUM5 - Gibberella moniliformis; See PMID 10413619; See PMID 11238987; uncharacterized protein 1439591 4980625 An03g06380 Aspergillus niger uncharacterized protein XP_059600372.1 1431197 D 5061 CDS An03g06390 4980626 complement(join(1440203..1440796,1440857..1441038,1441089..1441231,1441278..1441595,1441645..1442056,1442111..1442339)) VI 1 NT_166520.1 Function: MhpA is involved in 3-(3-hydroxyphenyl)propionate degradation.; Remark: C. testosteroni MhpA degrades 3-(3-hydroxyphenyl)propionate (3HPP) via the meta pathway.; Title: strong similarity to 3-(3-hydroxyphenyl)propionate hydroxylase MhpA - Comamonas testosteroni; See PMID 10537203; uncharacterized protein 1442339 4980626 An03g06390 Aspergillus niger uncharacterized protein XP_059600373.1 1440203 R 5061 CDS An03g06400 4980627 join(1442867..1443021,1443069..1443858,1443904..1444104,1444160..1444249,1444300..1444350,1444396..1444517,1444564..1445449) VI 1 NT_166520.1 Remark: the positively acting amdA gene of Aspergillus nidulans encodes a protein with two C2H2 zinc-finger motifs and mediates omega amino acid induction of the amdS acetamidase and aciA.; Title: similarity to zinc-finger transcription factor amdA - Aspergillus nidulans; nucleus; See PMID 7596297; See PMID 8119589; See PMID 9126617; uncharacterized protein 1445449 4980627 An03g06400 Aspergillus niger uncharacterized protein XP_059600374.1 1442867 D 5061 CDS An03g06410 4980628 join(1446226..1446367,1446415..1447089,1447142..1447194) VI 1 NT_166520.1 Function: ERG25 of S. cerevisiae performs the first of three enzymatic steps required to remove the two C-4 methyl groups leading to ergosterol.; Pathway: ERG25 of S. cerevisae is involved in the ergosterol biosynthesis pathway.; Title: strong similarity to methyl sterol oxidase Erg25 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 8663358; See PMID 9326581; uncharacterized protein 1447194 4980628 An03g06410 Aspergillus niger uncharacterized protein XP_001390516.3 1446226 D 5061 CDS An03g06420 4980629 join(1447993..1448530,1448627..1448880) VI 1 NT_166520.1 Similarity: the predicted A. niger protein shows also weak similarity to the Pfam Acetyltransferase (GNAT) family signature.; Title: similarity to hypothetical protein encoded by An08g08870 - Aspergillus niger; See PMID 10692350; uncharacterized protein 1448880 4980629 An03g06420 Aspergillus niger uncharacterized protein XP_001390517.1 1447993 D 5061 CDS An03g06430 4980630 join(1450294..1450467,1450519..1451130,1451186..1451482) VI 1 NT_166520.1 Catalytic activity: cinnamyl-alcohol dehydrogenases convert an Cinnamyl-alcohol+NADP(+) to an cinnamaldehyde + NADPH.; Function: M. sativa MsaCad1 catalyses the last step in the biosynthesis of the lignin monomers.; Induction: M. sativa MsaCad1 is wound-inducible, and the wound-responsiveness is modulated by salicylic acid.; Title: strong similarity to cinnamyl-alcohol dehydrogenase MsaCAD1 - Medicago sativa; See PMID 10092173; See PMID 10579494; uncharacterized protein 1451482 4980630 An03g06430 Aspergillus niger uncharacterized protein XP_001390518.1 1450294 D 5061 CDS An03g06440 4980631 complement(join(1451541..1452103,1452154..1452355)) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein EAA64120.1 - Aspergillus nidulans; uncharacterized protein 1452355 4980631 An03g06440 Aspergillus niger uncharacterized protein XP_001390519.1 1451541 R 5061 CDS An03g06450 4980632 complement(join(1452820..1452876,1452938..1453005,1453077..1453286,1453351..1453579)) VI 1 NT_166520.1 Title: weak similarity to protein SEQ ID NO: 2310 from patent US6562958-B1 - Acinetobacter baumannii; uncharacterized protein 1453579 4980632 An03g06450 Aspergillus niger uncharacterized protein XP_001390520.1 1452820 R 5061 CDS An03g06460 4980633 complement(join(1454024..1454189,1454236..1454866,1454911..1455040,1455087..1455227,1455276..1455306,1455354..1455664)) VI 1 NT_166520.1 Function: StcB from A. nidulans may be involved in the hydroxylation of averantin to form 5'-hydroxyaverantin,oxidation of averufin to 1-hydroxyversicolorone, and its oxidation to versiconal hemiacetal acetate.; Pathway: StcB from A. nidulans is involved in the sterigmatocystin biosynthesis.; Title: strong similarity to hypothetical sterigmatocystin biosynthesis p450 monooxygenase stcB -Aspergillus nidulans; See PMID 8643646; uncharacterized protein 1455664 4980633 An03g06460 Aspergillus niger uncharacterized protein XP_001390521.1 1454024 R 5061 CDS An03g06470 4980634 complement(join(1456591..1456967,1457265..1457367,1457421..1457797,1458190..1458726,1458779..1459000,1459097..1459415)) VI 1 NT_166520.1 Title: weak similarity to MigA - Dictyostelium discoideum; See PMID 9307972; uncharacterized protein 1459415 4980634 An03g06470 Aspergillus niger uncharacterized protein XP_059600375.1 1456591 R 5061 CDS An03g06480 4980635 join(1459940..1460577,1460627..1460880,1460928..1460992,1461069..1461983) VI 1 NT_166520.1 Remark: Steroid monooxygenase (smo) from R. rhodochrous is a Baeyer-Villigerase catalyzing the insertion of an oxygen atom between the C17- and C20-carbons of progesterone to produce testosterone.; Remark: the ORF coded protein shows also strong similarity to some hypothetical monooxygenases of secondary metabolism, MoxY Aspergillus parasiticus and StcW (Sterigmatocystin biosyntesis), Aspergillus nidulans.; Title: strong similarity to Steroid monooxygenase smo - Rhodococcus rhodochrous; See PMID 10467180; uncharacterized protein 1461983 4980635 An03g06480 Aspergillus niger uncharacterized protein XP_059600376.1 1459940 D 5061 CDS An03g06490 4980636 complement(join(1462110..1462257,1462320..1463067,1463159..1463378)) VI 1 NT_166520.1 Title: similarity to heroin esterase her -Rhodococcus sp.; See PMID 9143135; uncharacterized protein 1463378 4980636 An03g06490 Aspergillus niger uncharacterized protein XP_001390524.1 1462110 R 5061 CDS An03g06500 4980637 1464818..1466041 VI 1 NT_166520.1 Complex: N. plumbaginifolia ABA2 potentially uses FAD as cofactor.; Function: ABA2 from N. plumbaginifolia converts zeaxanthin into antheraxanthin and subsequently violaxanthin.; Function: N. plumbaginifolia ABA2 is involved in the epoxidation of zeaxanthin and plays an important role in resistance to stresses, seed development and dormancy.; Induction: N. plumbaginifolia ABA2 is upregulated in roots by drought stress.; Pathway: N. plumbaginifolia ABA2 is also involved in the xanthophyll cycle together with a yet unidentified de-epoxidase which converts violaxanthin into zeaxanthin.; Pathway: N. plumbaginifolia ABA2 is involed in the first step of the abscisic acid (ABA) biosynthesis pathway.; Remark: abscisic acid (ABA) is a plant hormone which plays an important role in seed development and dormancy and in plant response to environmental stresses.; Title: strong similarity to zeaxanthin epoxidase ABA2 - Nicotiana plumbaginifolia; See PMID 8665840; uncharacterized protein 1466041 4980637 An03g06500 Aspergillus niger uncharacterized protein XP_001390525.1 1464818 D 5061 CDS An03g06510 4980638 1466879..1468396 VI 1 NT_166520.1 Function: S. cerevisiae UGA3 is required for 4-aminobutyric acid (GABA)-dependent induction of the UGA1,UGA2 and UGA4 genes which encode the two GABA catabolic enzymes and a GABA-specific permease, respectively,required for the utilization of GABA as a nitrogen source.; Remark: UGA3 from S. cerevisiae was judged closest manual homolog to the predicted A. niger protein even so it shows only an E-val of 0. 003, but the similarity extends over the total length of both proteins.; Similarity: UGA3 of S. cerevisiae contains a Zn[2]-Cys[6] fungal-type binuclear cluster domain in the N-terminal region.; Title: weak similarity to regulator protein Uga3 -Saccharomyces cerevisiae; nucleus; See PMID 2109179; See PMID 7899074; uncharacterized protein 1468396 4980638 An03g06510 Aspergillus niger uncharacterized protein XP_059600377.1 1466879 D 5061 CDS An03g06520 84590770 complement(join(1469236..1469821,1469864..1469958)) VI 1 NT_166520.1 Similarity: the similarity between the two A. niger proteins is restricted to a stretch of about 80 amino acids.; Title: similarity to hypothetical protein encoded by An08g08730 - Aspergillus niger; uncharacterized protein 1469958 84590770 An03g06520 Aspergillus niger uncharacterized protein XP_059600378.1 1469236 R 5061 CDS An03g06530 4980640 complement(join(1474506..1474695,1474762..1474827,1474888..1475040,1475091..1475487,1475542..1475712,1475772..1476109,1476173..1476333)) VI 1 NT_166520.1 Remark: A. vitis ttuB codes for a protein with homology to transporter proteins and is required for entry of tartrate.; Title: strong similarity to tartrate transport protein ttuB - Agrobacterium vitis; See PMID 7592429; uncharacterized protein 1476333 4980640 An03g06530 Aspergillus niger uncharacterized protein XP_001390528.1 1474506 R 5061 CDS An03g06540 4980641 complement(join(1477265..1477600,1477658..1477779,1477829..1478321,1478371..1478849,1478914..1479229)) VI 1 NT_166520.1 Catalytic activity: arylsulfatases convert a phenol sulfate + H(2)O to a phenol + sulfate.; Remark: N. crassa ars-1 is expressed under conditions of sulfur limitation and is under coordinate control of the cys-3+ and scon+ regulatory genes.; Title: strong similarity to arylsulfatase ars-1 -Neurospora crassa; See PMID 2528685; uncharacterized protein 1479229 4980641 An03g06540 Aspergillus niger uncharacterized protein XP_001390529.1 1477265 R 5061 CDS An03g06550 4980642 complement(join(1480115..1480801,1480860..1481497,1481559..1481655,1481711..1481997,1482073..1482286)) VI 1 NT_166520.1 Gene-ID: glaA;gla;amyG; Mapping: glaA from A. niger is mapped to chromosome VI (LG VI); see list from DSM, PUBMED 8041364.; Remark: a synonym for glaA is amyG.; Remark: glaA is alternative spliced and encodes preproglucoamylase G1 and preproglucoamylase G2.; extracellular/secretion proteins; See PMID 6204865; See PMID 6440004; See PMID 207655; See PMID 9649747; See PMID 1077246; glucan 1,4-alpha-glucosidase glaA-Aspergillus niger 1482286 glaA 4980642 glaA Aspergillus niger glucan 1,4-alpha-glucosidase glaA-Aspergillus niger XP_001390530.1 1480115 R 5061 CDS An03g06560 4980643 complement(1482938..1484626) VI 1 NT_166520.1 Catalytic activity: lipases convert triacylglycerol + H(2)O to diacylglycerol + a fatty acid anion.; Function: C. rugosa LIP2 is involved in glycerolipid metabolism and phospholipid degradation.; Remark: Candida rugosa is synonymous to Candida cylindracea.; Title: strong similarity to triacylglycerol lipase Lip2 - Candida rugosa; See PMID 8509417; See PMID 1610906; uncharacterized protein 1484626 4980643 An03g06560 Aspergillus niger uncharacterized protein XP_001390531.1 1482938 R 5061 CDS An03g06570 4980644 complement(1485522..1486205) VI 1 NT_166520.1 Remark: PAD1 confers resistance to cinnamic acid in S. cerevisiae.; Title: strong similarity to phenylacrylic acid decarboxylase Pad1 - Saccharomyces cerevisiae; See PMID 8181743; uncharacterized protein 1486205 4980644 An03g06570 Aspergillus niger uncharacterized protein XP_001390532.1 1485522 R 5061 CDS An03g06580 4980645 complement(join(1486587..1486698,1486758..1487540,1487589..1487736,1487870..1488126,1488174..1488760)) VI 1 NT_166520.1 Function: in F. solani cutinase induction by cutin monomers is regulated by CTF1.; Similarity: similarity is between the Zn(2)-Cys(6) domain containing N-terminal half of the predicted A. niger protein and F. solani CTF1.; Similarity: the predicted A. niger protein contains a Zn(2)-Cys(6), fungal-type binuclear cluster domain.; Title: similarity to cutinase transcription factor 1 CTF1-beta - Fusarium solani; nucleus; See PMID 8132657; uncharacterized protein 1488760 4980645 An03g06580 Aspergillus niger uncharacterized protein XP_059600379.1 1486587 R 5061 CDS An03g06590 4980646 complement(join(1489399..1489932,1489985..1490953)) VI 1 NT_166520.1 Catalytic activity: 4-hydroxybenzoate decarboxylases convert 4-hydroxybenzoate to phenol + CO(2).; Complex: the 4-hydroxybenzoate decarboxylase from C. hydroxybenzoicum had an apparent molecular mass of 350 kDa and consisted of six identical subunits of 57 kDa each.; Title: strong similarity to 4-hydroxybenzoate decarboxylase OHB1 - Clostridium hydroxybenzoicum; See PMID 7744052; See PMID 10438791; uncharacterized protein 1490953 4980646 An03g06590 Aspergillus niger uncharacterized protein XP_001390534.1 1489399 R 5061 CDS An03g06600 4980647 join(1492128..1492183,1492230..1492356,1492426..1492983) VI 1 NT_166520.1 Similarity: similarity is between many probable Zinc-finger transcription factors and the N-terminal region of the predicted A. niger protein, which contains a BTB/POZ domain found in many Zn-finger transcription factors and required for homodimerisation.; Title: similarity to hypothetical protein KIAA0352 -Homo sapiens; uncharacterized protein 1492983 4980647 An03g06600 Aspergillus niger uncharacterized protein XP_001390535.1 1492128 D 5061 CDS An03g06610 84590771 join(1494023..1494257,1494310..1495001) VI 1 NT_166520.1 hypothetical protein 1495001 84590771 An03g06610 Aspergillus niger hypothetical protein XP_059600380.1 1494023 D 5061 CDS An03g06620 4980649 join(1495496..1495549,1495772..1496248,1496361..1496378) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein aq_928 - Aquifex aeolicus; See PMID 9537320; uncharacterized protein 1496378 4980649 An03g06620 Aspergillus niger uncharacterized protein XP_059600381.1 1495496 D 5061 CDS An03g06630 4980650 complement(join(1496523..1496854,1496902..1497117,1497165..1497626,1497673..1497987,1498039..1498123,1498171..1498383)) VI 1 NT_166520.1 Catalytic activity: lipases convert triacylglycerol + H(2)O to diacylglycerol + a fatty acid anion.; Function: C. rugosa LIP1 is involved in glycerolipid metabolism and phospholipid degradation.; Remark: Candida rugosa is synonymous to Candida cylindracea.; Title: similarity to lipase LIP1 - Candida rugosa; See PMID 8509417; See PMID 1610906; uncharacterized protein 1498383 4980650 An03g06630 Aspergillus niger uncharacterized protein XP_059600382.1 1496523 R 5061 CDS An03g06640 4980651 complement(join(1499148..1499253,1499299..1499363,1499411..1499551)) VI 1 NT_166520.1 Remark: blastp with the predicted A. niger protein only retrieves random hits to glycine and cysteine rich proteins.; Title: similarity to hypothetical protein encoded by An08g11130 - Aspergillus niger; uncharacterized protein 1499551 4980651 An03g06640 Aspergillus niger uncharacterized protein XP_001390539.1 1499148 R 5061 CDS An03g06650 4980652 join(1500749..1501298,1501348..1501947,1502017..1502217,1502455..1502548,1502724..1502826) VI 1 NT_166520.1 Remark: S. coelicolor SC4G1. 04c is a putative integral membrane protein.; Title: similarity to hypothetical protein SC4G1.04c - Streptomyces coelicolor; uncharacterized protein 1502826 4980652 An03g06650 Aspergillus niger uncharacterized protein XP_059600383.1 1500749 D 5061 CDS An03g06660 4980653 join(1504534..1504867,1504913..1505035,1505081..1505303,1505352..1505720,1505774..1505928,1505977..1506659) VI 1 NT_166520.1 Function: A. thaliana ptr2 imports dipeptides and tripeptides but not peptides four residues and higher.; Title: strong similarity to peptide transporter PTR2 - Arabidopsis thaliana; plasma membrane; See PMID 7919993; uncharacterized protein 1506659 4980653 An03g06660 Aspergillus niger uncharacterized protein XP_001390541.1 1504534 D 5061 CDS An03g06670 4980654 complement(join(1507013..1512129,1512186..1512861,1512915..1513364)) VI 1 NT_166520.1 Function: S. cerevisiae MLP1 has been associated with the nuclear pore and is implicated in nuclear transport.; Title: weak similarity to myosin-like protein Mlp1 -Saccharomyces cerevisiae; See PMID 10085285; uncharacterized protein 1513364 4980654 An03g06670 Aspergillus niger uncharacterized protein XP_059600384.1 1507013 R 5061 CDS An03g06680 84590772 join(1515370..1515424,1515667..1516356,1516398..1516618,1516677..1516768,1516887..1516902) VI 1 NT_166520.1 hypothetical protein 1516902 84590772 An03g06680 Aspergillus niger hypothetical protein XP_059600385.1 1515370 D 5061 CDS An03g06690 4980656 complement(join(1517749..1517846,1517919..1518849,1518909..1519229)) VI 1 NT_166520.1 Catalytic activity: salicylate hydroxylases convert salicylate + NADH + O(2) to catechol + NAD(+) + H(2)O + CO(2).; Pathway: nahpthalene, salicylate, and phenylalanine metabolism.; Title: strong similarity to salicylate hydroxylase nahG - Pseudomonas stutzeri; uncharacterized protein 1519229 4980656 An03g06690 Aspergillus niger uncharacterized protein XP_001390544.1 1517749 R 5061 CDS An03g06700 4980657 complement(join(1520062..1520080,1520126..1521549)) VI 1 NT_166520.1 Catalytic activity: cyclohexanone monooxygenases convert cyclohexanone + NADPH + O(2) to 6-hexanolide + NADP(+) + H(2)O.; Pathway: Acinetobacter chnB is involved in the cyclohexanol catabolic pathway.; Remark: Acinetobacter chnB is a flavoprotein (FAD) and acts on a number of different cyclic ketones.; Title: similarity to cyclohexanone monooxygenase chnB - Acinetobacter sp.; See PMID 3338974; See PMID 10543838; uncharacterized protein 1521549 4980657 An03g06700 Aspergillus niger uncharacterized protein XP_059600386.1 1520062 R 5061 CDS An03g06710 4980658 complement(join(1522370..1522719,1522817..1523132,1523485..1523755,1523810..1524203,1524253..1524577)) VI 1 NT_166520.1 Function: human retSDR2 catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.; Title: similarity to retinal short-chain dehydrogenase/reductase retSDR2 - Homo sapiens; See PMID 10800688; uncharacterized protein 1524577 4980658 An03g06710 Aspergillus niger uncharacterized protein XP_001390546.3 1522370 R 5061 CDS An03g06720 4980659 join(1525108..1525190,1525343..1525765,1525828..1526212,1526277..1526754,1526811..1526911) VI 1 NT_166520.1 Catalytic activity: cytochrome P-450s convert RH + reduced flavoprotein + O(2) to ROH + oxidized flavoprotein +H(2)O.; Function: D. melanogaster CYP4D2 is involved in the metabolism of insect hormones.; Similarity: D. melanogaster CYP4D2 belongs to the cytochrome p450 family.; Title: strong similarity to cytochrome P-450 CYP4D2 - Drosophila melanogaster; See PMID 8024706; See PMID 8676871; uncharacterized protein 1526911 4980659 An03g06720 Aspergillus niger uncharacterized protein XP_059600387.1 1525108 D 5061 CDS An03g06730 4980660 complement(join(1526979..1527549,1527754..1527831,1527910..1528359,1528514..1528732,1528789..1528877,1528958..1529047)) VI 1 NT_166520.1 Function: P. denitrificans cobW might be involved in cobalt reduction leading to cobalt(i) corrinoids.; Pathway: P. denitrificans cobW might take part in cobalamin biosynthesis.; Title: similarity to cobW - Pseudomonas denitrificans; See PMID 7765511; See PMID 1655697; uncharacterized protein 1529047 4980660 An03g06730 Aspergillus niger uncharacterized protein XP_059600388.1 1526979 R 5061 CDS An03g06740 4980661 complement(join(1529427..1529816,1529869..1530114,1530178..1530344,1530420..1530591,1530661..1531002)) VI 1 NT_166520.1 Catalytic activity: 1,4-polygalacturonases convert (1,4-alpha-D-galacturonide)n + H(2)O to (1,4-alpha-D-galacturonide)n-1 + D-galacturonate.; Localization: C. carbonum PGX1 is an extracellular enzyme.; Title: strong similarity to exo-alpha 1,4-polygalacturonase PGX1 - Cochliobolus carbonum; extracellular/secretion proteins; See PMID 9546185; uncharacterized protein 1531002 4980661 An03g06740 Aspergillus niger uncharacterized protein XP_059600389.1 1529427 R 5061 CDS An03g06750 4980662 complement(join(1532261..1532561,1532613..1532617)) VI 1 NT_166520.1 Similarity: the ORF shows strong similarity to another A. niger protein, An11g09050. An11g09050 is longer than the ORF (168 compared to 101 amino acids).; Title: similarity to hypothetical protein encoded by An11g09050 - Aspergillus niger; uncharacterized protein 1532617 4980662 An03g06750 Aspergillus niger uncharacterized protein XP_001390550.3 1532261 R 5061 CDS An03g06760 4980663 complement(join(1532796..1532876,1532925..1532999,1533047..1534639,1534692..1535243)) VI 1 NT_166520.1 Title: strong similarity to hypothetical transcription regulator protein CAA91958.1 -Schizosaccharomyces pombe; uncharacterized protein 1535243 4980663 An03g06760 Aspergillus niger uncharacterized protein XP_001390551.1 1532796 R 5061 CDS An03g06770 4980664 join(1538425..1539504,1539566..1539701,1539930..1539970) VI 1 NT_166520.1 hypothetical protein 1539970 4980664 An03g06770 Aspergillus niger hypothetical protein XP_059600390.1 1538425 D 5061 CDS An03g06780 84590773 join(1540633..1540767,1540833..1541121,1541159..1541243,1541291..1541300) VI 1 NT_166520.1 hypothetical protein 1541300 84590773 An03g06780 Aspergillus niger hypothetical protein XP_059600391.1 1540633 D 5061 CDS An03g06790 4980666 complement(join(1542733..1543149,1543201..1543971)) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein B1D4.110 - Neurospora crassa; uncharacterized protein 1543971 4980666 An03g06790 Aspergillus niger uncharacterized protein XP_059600392.1 1542733 R 5061 CDS An03g06800 4980667 complement(join(1545470..1545626,1545682..1545929,1545983..1548148)) VI 1 NT_166520.1 Title: strong similarity to hypothetical negative-acting regulatory protein qutR - Aspergillus nidulans; uncharacterized protein 1548148 4980667 An03g06800 Aspergillus niger uncharacterized protein XP_001390555.3 1545470 R 5061 CDS An03g06810 4980668 1552006..1554405 VI 1 NT_166520.1 Similarity: the similarity of the predicted ORF to A. nidulans QUTA is restricted to its N-terminal half; additionally, the A. niger ORF is 108 amino acids shorter at the N-terminus.; Title: strong similarity to regulator protein qutA -Aspergillus nidulans; See PMID 3313276; uncharacterized protein 1554405 4980668 An03g06810 Aspergillus niger uncharacterized protein XP_059600393.1 1552006 D 5061 CDS An03g06820 4980669 complement(join(1556474..1557563,1557622..1558238)) VI 1 NT_166520.1 Title: similarity to negative regulatory protein Hex2 - Saccharomyces cerevisiae; See PMID 1889400; uncharacterized protein 1558238 4980669 An03g06820 Aspergillus niger uncharacterized protein XP_001390557.1 1556474 R 5061 CDS An03g06830 4980670 join(1564442..1564505,1564596..1564615,1564774..1564861,1564946..1565367) VI 1 NT_166520.1 Title: strong similarity to hypothetical protein B24P7.10 - Neurospora crassa; uncharacterized protein 1565367 4980670 An03g06830 Aspergillus niger uncharacterized protein XP_001390558.1 1564442 D 5061 CDS An03g06840 4980671 complement(join(1565541..1566267,1566324..1566983,1567059..1567138)) VI 1 NT_166520.1 hypothetical protein 1567138 4980671 An03g06840 Aspergillus niger hypothetical protein XP_059600394.1 1565541 R 5061 CDS An03g06850 4980672 complement(join(1567635..1567775,1567839..1567984,1568068..1568119)) VI 1 NT_166520.1 Title: strong similarity to hypothetical coiled-coil protein cgrA - Aspergillus nidulans; uncharacterized protein 1568119 4980672 An03g06850 Aspergillus niger uncharacterized protein XP_001390560.1 1567635 R 5061 CDS An03g06860 4980673 join(1568798..1568908,1568973..1569851) VI 1 NT_166520.1 Title: strong similarity to hypothetical mitochondrial transport protein Arg11 - Saccharomyces cerevisiae; uncharacterized protein 1569851 4980673 An03g06860 Aspergillus niger uncharacterized protein XP_001390561.1 1568798 D 5061 CDS An03g06870 4980674 join(1570622..1570706,1570784..1570917,1571048..1571133,1571343..1571424,1571499..1571540) VI 1 NT_166520.1 Catalytic activity: Cytidine + H(2)O <=> uridine + NH(3); Title: strong similarity to cytidine deaminase -Homo sapiens; uncharacterized protein 1571540 4980674 An03g06870 Aspergillus niger uncharacterized protein XP_001390562.1 1570622 D 5061 CDS An03g06880 4980675 complement(join(1572401..1573040,1573130..1576437,1576471..1576941)) VI 1 NT_166520.1 Title: strong similarity to carboxypeptidase Y-sorting protein Pep1 - Saccharomyces cerevisiae; uncharacterized protein 1576941 4980675 An03g06880 Aspergillus niger uncharacterized protein XP_059600395.1 1572401 R 5061 CDS An03g06890 84590774 complement(1578299..1579195) VI 1 NT_166520.1 Title: similarity to hypothetical protein B16B8.140 - Neurospora crassa; uncharacterized protein 1579195 84590774 An03g06890 Aspergillus niger uncharacterized protein XP_059600396.1 1578299 R 5061 CDS An03g06900 4980677 complement(join(1580637..1581143,1581204..1582642,1582709..1583384)) VI 1 NT_166520.1 Function: it is suggested that hSec10p is a component of the mammalian counterpart of the yeast exocyst complex essential for post-Golgi traffic.; Remark: SEC10 gene product is a member of the exocyst complex essential for exocytosis in the budding yeast S. cerevisiae.; Remark: alternate name in S. cerevisiae = YLR166C.; Title: strong similarity to exocytosis protein Sec10 - Saccharomyces cerevisiae; See PMID 8978675; See PMID 9119050; See PMID 9658167; uncharacterized protein 1583384 4980677 An03g06900 Aspergillus niger uncharacterized protein XP_059600397.1 1580637 R 5061 CDS An03g06910 4980678 join(1584324..1584813,1584912..1585217,1585305..1585510) VI 1 NT_166520.1 Title: strong similarity to hypothetical 32.0k protein - Neurospora crassa; uncharacterized protein 1585510 4980678 An03g06910 Aspergillus niger uncharacterized protein XP_059600398.1 1584324 D 5061 CDS An03g06915 84590775 complement(join(1585986..1586610,1586692..1586870)) VI 1 NT_166520.1 Title: weak similarity to hypothetical protein B14D6.5 - Neurospora crassa; uncharacterized protein 1586870 84590775 An03g06915 Aspergillus niger uncharacterized protein XP_059600399.1 1585986 R 5061 CDS An03g06920 4980681 join(1588744..1589007,1589109..1590474,1590551..1591014) VI 1 NT_166520.1 Title: similarity to hypothetical protein CG5336 -Drosophila melanogaster; uncharacterized protein 1591014 4980681 An03g06920 Aspergillus niger uncharacterized protein XP_001390568.1 1588744 D 5061 CDS An03g06930 4980682 join(1592097..1592588,1592727..1594505) VI 1 NT_166520.1 Function: checkpoint pathways act to arrest mitosis and prevent the attempted segregation of damaged or unreplicated DNA.; Function: rad17 function is not essential for growth, but is required for the function of the DNA structure-dependent checkpoints.; Function: rad17 gene product is a basic hydrophilic protein of 606 amino acids which contains five domains with sequence homology to replication factor C (RF-C)/activator 1 subunits.; Localization: rad17 is localized in the nucleus.; Similarity: no similarity at the aminoterminal part.; Title: similarity to protein involved in cell cycle control rad17p - Schizosaccharomyces pombe; nucleus; See PMID 8846774; uncharacterized protein 1594505 4980682 An03g06930 Aspergillus niger uncharacterized protein XP_001390569.1 1592097 D 5061 CDS An03g06940 4980683 join(1595872..1596016,1596185..1596776,1596939..1597272) VI 1 NT_166520.1 Function: transports UDP-N-acetylglucosamine from the cytosol to the luminal side of the Golgi apparatus.; Golgi; Title: strong similarity to UPD-GlcNAc transporter MNN2-2 - Kluyveromyces lactis; See PMID 10037760; uncharacterized protein 1597272 4980683 An03g06940 Aspergillus niger uncharacterized protein XP_059600400.1 1595872 D 5061 CDS An03g06950 4980684 complement(join(1597736..1598050,1598119..1600101,1600167..1600265)) VI 1 NT_166520.1 Function: cells with a disruption in the DNM1 gene showed mating response defects consistent with a delay in receptor-mediated endocytosis.; Function: during receptor-mediated endocytosis,Dnm1p acts after internalization, but before fusion with the vacuole.; Function: findings show that like mammalian dynamin,Dnm1p participates in endocytosis.; Title: strong similarity to dynamin-related protein Dnm1 - Saccharomyces cerevisiae; See PMID 7622557; uncharacterized protein 1600265 4980684 An03g06950 Aspergillus niger uncharacterized protein XP_059600401.1 1597736 R 5061 CDS An03g06960 4980685 complement(join(1601038..1601124,1601245..1603113,1603171..1603358,1603412..1603616)) VI 1 NT_166520.1 Function: because the actin-binding protein ABP1p is associated with the cortical cytoskeleton of S. cerevisiae, it might be involved in the spatial organization of cell surface growth.; Function: in yeast, the cortical actin cytoskeleton seems to specify sites of growth of the cell surface.; Title: strong similarity to actin-binding protein Abp1 - Saccharomyces cerevisiae; cytoskeleton; uncharacterized protein 1603616 4980685 An03g06960 Aspergillus niger uncharacterized protein XP_001390572.1 1601038 R 5061 CDS An03g06970 4980686 join(1605151..1606527,1606579..1607699,1607776..1607912,1607966..1608306) VI 1 NT_166520.1 Catalytic activity: AMP deaminase catalyzes the hydrolytic deamination of AMP into IMP.; Function: it contains three regions that are centered on residues which are proposed to play an important role in the catalytic mechanism.; Similarity: shows very strong similarity in the middle part of the protein to amp deaminase of several species.; Title: strong similarity to AMP deaminase Amd1 -Saccharomyces cerevisiae; See PMID 2690949; uncharacterized protein 1608306 4980686 An03g06970 Aspergillus niger uncharacterized protein XP_059600402.1 1605151 D 5061 CDS An03g06980 84590776 complement(1608549..>1609799) VI 1 NT_166520.1 Remark: truncated ORF due to contig border.; Title: similarity to hypothetical protein B24M22.160 - Neurospora crassa [truncated ORF]; uncharacterized protein 1609799 84590776 An03g06980 Aspergillus niger uncharacterized protein XP_059600403.1 1608549 R 5061 CDS An04g00010 4990401 join(<1..44,110..290,425..457) VI 1 NT_166539.1 Remark: N-terminal truncated ORF due to end of contig.; hypothetical protein [truncated ORF] 457 4990401 An04g00010 Aspergillus niger hypothetical protein [truncated ORF] XP_059600404.1 1 D 5061 CDS An04g00020 4990404 complement(join(791..1125,1180..4502,4544..4587,4690..5010)) VI 1 NT_166539.1 Remark: Nup133p, functionally overlaps with the NUP145 gene product, Nup145p, and these proteins may be involved in maintaining the position of the NPC within the nuclear envelope.; Title: strong similarity to nuclear pore protein Nup133 - Saccharomyces cerevisiae; See PMID 7626806; See PMID 7813444; See PMID 7862658; See PMID 9049242; uncharacterized protein 5010 4990404 An04g00020 Aspergillus niger uncharacterized protein XP_059600405.1 791 R 5061 CDS An04g00030 84590777 complement(join(5213..5250,5329..5443,5637..5672)) VI 1 NT_166539.1 hypothetical protein 5672 84590777 An04g00030 Aspergillus niger hypothetical protein XP_059600406.1 5213 R 5061 CDS An04g00040 4990405 join(5854..5920,5963..7020) VI 1 NT_166539.1 Catalytic activity: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein].; Pathway: fatty acid biosynthesis (path 1).; Remark: the amino acid sequence of B. subtilis acyl carrier protein was obtained by sequencing the purified protein, and the sequence obtained strongly resembled that of E. coli acyl carrier protein, except that most of the protein retained the initiating methionine residue.; Similarity: belongs to the [acyl-carrier-protein] S-malonyltransferases.; Title: strong similarity to S-malonyltransferase fabD - Bacillus subtilis; See PMID 8759840; uncharacterized protein 7020 4990405 An04g00040 Aspergillus niger uncharacterized protein XP_059600407.1 5854 D 5061 CDS An04g00050 4990406 complement(join(7486..7650,7715..8005,8057..8101)) VI 1 NT_166539.1 Remark: the predicted ORF shows homology to an A. niger EST an_2403.; Title: similarity to cancer associated protein sequence SEQ ID NO:919 from patent WO200055350-A1 - Homo sapiens; uncharacterized protein 8101 4990406 An04g00050 Aspergillus niger uncharacterized protein XP_059600408.1 7486 R 5061 CDS An04g00060 4990408 join(9400..9454,9502..9694,9749..10104,10161..10255) VI 1 NT_166539.1 Catalytic activity: NADH + ubiquinone = NAD+ + ubiquinol.; Pathway: oxidative phosphorylation, respiratory chain complex I.; Remark: 19. 3 kD subunit of the respiratory chain complex I is binding to iron-sulphur cluster N-2.; Title: strong similarity to 19.3 kD subunit of NADH:ubiquinone reductase - Neurospora crassa; localisation:mitochondrion; See PMID 10216160; uncharacterized protein 10255 4990408 An04g00060 Aspergillus niger uncharacterized protein XP_001401369.1 9400 D 5061 CDS An04g00070 4990403 join(11559..12351,12469..13676) VI 1 NT_166539.1 Remark: alternative name is YJR002w.; Remark: depletion of Mpp10, a U3 snoRNP-specific protein, halts 18S rRNA production and impairs cleavage at the three U3 snoRNP-dependent sites: A0, A1, and A2.; Title: strong similarity to component of the U3 small nucleolar ribonucleoprotein Mpp10 - Saccharomyces cerevisiae; See PMID 9315638; See PMID 9391061; uncharacterized protein 13676 4990403 An04g00070 Aspergillus niger uncharacterized protein XP_059600409.1 11559 D 5061 CDS An04g00080 4990407 complement(join(13780..14251,14347..14564)) VI 1 NT_166539.1 Title: strong similarity to hypothetical membrane protein YNL024c - Saccharomyces cerevisiae; uncharacterized protein 14564 4990407 An04g00080 Aspergillus niger uncharacterized protein XP_001401371.1 13780 R 5061 CDS An04g00090 84590778 join(15414..15482,15577..15624,15675..15776) VI 1 NT_166539.1 hypothetical protein 15776 84590778 An04g00090 Aspergillus niger hypothetical protein XP_059600410.1 15414 D 5061 CDS An04g00100 4990409 join(15970..15985,16069..16373,16452..16595) VI 1 NT_166539.1 Remark: also strong similarity to EST an_2885 from Aspergillus niger.; Title: strong similarity to hypothetical protein SPAC15E1.02c - Schizosaccharomyces pombe; uncharacterized protein 16595 4990409 An04g00100 Aspergillus niger uncharacterized protein XP_001401373.1 15970 D 5061 CDS An04g00110 4990411 complement(join(17256..17280,17333..17829,17896..17965,18040..18100,18194..18383)) VI 1 NT_166539.1 Catalytic activity: NADH + ubiquinone = NAD+ + ubiquinol.; Pathway: oxidative phosphorylation, respiratory chain complex I.; Remark: also strong similarity to EST an_3610 Aspergillus niger.; Title: strong similarity to 21/29 kD subunit of NADH:ubiquinone reductase - Neurospora crassa; localisation:mitochondrion; See PMID 2137337; uncharacterized protein 18383 4990411 An04g00110 Aspergillus niger uncharacterized protein XP_001401374.3 17256 R 5061 CDS An04g00120 4990412 complement(join(18562..18926,19098..19374)) VI 1 NT_166539.1 Remark: also strong similarity to Aspergillus niger EST SEQ ID NO:4000.; Remark: alternative name is YIL010w.; Remark: the ends of chromosomes in S. cerevisiae initiate a repressive chromatin structure that spreads internally and inhibits the transcription of nearby genes,a phenomenon termed telomeric silencing.; Similarity: to P. falciparum merozoite cap protein-1 and E. coli bacterioferritin comigratory protein.; Title: strong similarity to derepression of telomeric silencing protein Dot5 - Saccharomyces cerevisiae; See PMID 9755194; uncharacterized protein 19374 4990412 An04g00120 Aspergillus niger uncharacterized protein XP_001401375.1 18562 R 5061 CDS An04g00130 4990413 join(20516..20668,20737..21156) VI 1 NT_166539.1 Remark: the identification of YAP19 S. cerevisiae supports the proposal that yeast cells also contain the Golgi-associated clathrin-assembly protein complex.; Title: strong similarity to intramitochondrial sorting protein YLR168c - Saccharomyces cerevisiae; See PMID 8373805; uncharacterized protein 21156 4990413 An04g00130 Aspergillus niger uncharacterized protein XP_001401376.1 20516 D 5061 CDS An04g00140 4990414 join(22171..22294,22352..22469,22519..23293,23356..23673) VI 1 NT_166539.1 Catalytic activity: CTP + ethanolamine phosphate = pyrophosphate + CDPethanolamine.; Pathway: aminophosphonate metabolism; glycerolipid metabolism.; Remark: CTP:phosphoethanolamine cytidylyltransferase (ET) is a key regulatory enzyme in the CDP-ethanolamine pathway for phosphatidylethanolamine synthesis.; Similarity: belongs to the cytidylyltransferases.; Title: strong similarity to CTP:phosphoethanolamine cytidylyltransferase ET - Rattus norvegicus; See PMID 10493918; uncharacterized protein 23673 4990414 An04g00140 Aspergillus niger uncharacterized protein XP_001401377.1 22171 D 5061 CDS An04g00150 4990415 complement(join(24082..24233,24302..24550,24603..24615)) VI 1 NT_166539.1 Remark: Grx5 plays a specially important role in protection against oxidative stress both during ordinary growth conditions and after externally induced damage. Grx5-deficient mutants are also sensitive to osmotic stress, which indicates a relationship between the two types of stress in yeast cells.; Remark: the synonyme for GRX5 is YPL059w.; Similarity: subfamily of yeast glutaredoxins (Grx3,Grx4, and Grx5) that differs from the first (Grx1 and Grx2) in containing a single cysteine residue at the putativeactive site.; Title: strong similarity to glutaredoxins Grx5 -Saccharomyces cerevisiae; See PMID 10567543; uncharacterized protein 24615 4990415 An04g00150 Aspergillus niger uncharacterized protein XP_059600411.1 24082 R 5061 CDS An04g00160 4990416 join(24916..24920,25048..25129,25381..26115) VI 1 NT_166539.1 Remark: putatively involved in cell cycle-specific gene expression.; Remark: strong similarity to human receptor molecule (REC) encoded by Incyte clone 2022379 patent WO9957270-A2.; Title: strong similarity to receptor molecule REC from patent WO9957270-A2 - Homo sapiens; uncharacterized protein 26115 4990416 An04g00160 Aspergillus niger uncharacterized protein XP_001401379.3 24916 D 5061 CDS An04g00170 4990417 complement(26170..27429) VI 1 NT_166539.1 Function: the enzyme (EC:2. 5. 1-) catalyzes the prenylation of para-hydroxybenzoate.; Remark: coenzyme Q functions as a lipid-soluble electron carrier in eukaryotes. In S. cerevisiae, the enzymes responsible for the assembly of the polyisoprenoid side chain and subsequent transfer to para-hydroxybenzoate (PHB) are encoded by the nuclear genes COQ1 and COQ2,respectively. Disruption of the chromosomal COQ2 gene indicates the gene is not essential for viability, yet is required for PHB:polyprenyltransferase activity and respiratory function.; Title: strong similarity to para-hydroxybenzoate polyprenyltransferase Coq2 - Saccharomyces cerevisiae; See PMID 1740455; uncharacterized protein 27429 4990417 An04g00170 Aspergillus niger uncharacterized protein XP_001401380.3 26170 R 5061 CDS An04g00180 4990418 join(28361..28628,28696..30701) VI 1 NT_166539.1 Title: similarity to hypothetical c-module-binding factor B21O8.50 - Neurospora crassa; uncharacterized protein 30701 4990418 An04g00180 Aspergillus niger uncharacterized protein XP_001401381.1 28361 D 5061 CDS An04g00190 4990419 complement(join(30981..31075,31159..31489,31568..31780)) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein CAD70403.1 - Neurospora crassa; uncharacterized protein 31780 4990419 An04g00190 Aspergillus niger uncharacterized protein XP_059600412.1 30981 R 5061 CDS An04g00200 4990420 join(32085..32549,32642..32734) VI 1 NT_166539.1 Title: strong similarity to hypothetical membrane protein YIL157c - Saccharomyces cerevisiae; uncharacterized protein 32734 4990420 An04g00200 Aspergillus niger uncharacterized protein XP_001401383.1 32085 D 5061 CDS An04g00210 4990421 complement(join(33107..33207,33288..34104)) VI 1 NT_166539.1 Remark: the intact MRP-L9 gene from S. cerevisiae is essential for mitochondrial function. YmL9 shows significant sequence similarities to Escherichia coli ribosomal protein L3 and related proteins from various organisms of all three natural kingdoms as well as photosynthetic organelles (cyanelles).; Title: strong similarity to ribosomal protein of the large subunit Yml9 - Saccharomyces cerevisiae; See PMID 1597181; See PMID 2060626; See PMID 3060376; mitochondrial 54S ribosomal protein uL3m 34104 4990421 An04g00210 Aspergillus niger mitochondrial 54S ribosomal protein uL3m XP_001401384.1 33107 R 5061 CDS An04g00220 4990422 join(34855..35446,35539..35686,35821..35947) VI 1 NT_166539.1 Catalytic activity: acetyl-CoA + peptide = CoA + Nalpha-acetylpeptide.; Remark: N alpha-Acetylation is catalyzed by N alpha-acetyltransferases, which transfer acetyl groups from acetyl coenzyme A to the N termini of most eukaryotic proteins co-translationally.; Remark: acetylates N-terminal alanine, serine,methionine and glutamate residues in a number of peptides and proteins, including beta-endorphin, corticotropins and alpha-melanotropin.; Title: strong similarity to methionine-N-acetyltransferase Nat2 - Saccharomyces cerevisiae; See PMID 8175741; uncharacterized protein 35947 4990422 An04g00220 Aspergillus niger uncharacterized protein XP_059600413.1 34855 D 5061 CDS An04g00230 84590779 complement(join(36225..36440,36526..36695,36764..39014,39189..39236,39303..39443,39502..39552,39608..39730,39835..>39921)) VI 1 NT_166539.1 Protein sequence is in conflict with the conceptual translation; Remark: putative sequencing error at position 23746 exchanging an G to T to generate an ATG.; Remark: the NUC-2 protein from N. crassa appears to sense the availability of phosphate and transmits the signal downstream to the regulatory pathway.; Title: strong similarity to ankyrin repeat protein Nuc-2 - Neurospora crassa [putative sequencing error]; putative sequencing error; See PMID 8917314; uncharacterized protein 39921 84590779 An04g00230 Aspergillus niger uncharacterized protein XP_059600414.1 36225 R 5061 CDS An04g00240 84590780 join(40608..40779,40872..40979,41073..41250,41391..41529) VI 1 NT_166539.1 Title: weak similarity to basic fibroblast growth factor precursor bFGF - Homo sapiens; uncharacterized protein 41529 84590780 An04g00240 Aspergillus niger uncharacterized protein XP_059600415.1 40608 D 5061 CDS An04g00250 4990425 complement(join(42446..43740,43845..43854)) VI 1 NT_166539.1 Similarity: unspecific to serine/threonine-rich proteins.; Title: strong similarity to hypothetical protein CAD70464.1 - Neurospora crassa; uncharacterized protein 43854 4990425 An04g00250 Aspergillus niger uncharacterized protein XP_001401388.1 42446 R 5061 CDS An04g00260 84590781 complement(join(44429..44628,44707..44843,44941..44994,45090..45280)) VI 1 NT_166539.1 hypothetical protein 45280 84590781 An04g00260 Aspergillus niger hypothetical protein XP_059600416.1 44429 R 5061 CDS An04g00270 4990427 complement(join(46529..46769,46823..48520,48638..48780)) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein CAD70410.1 - Neurospora crassa; uncharacterized protein 48780 4990427 An04g00270 Aspergillus niger uncharacterized protein XP_001401390.3 46529 R 5061 CDS An04g00280 84590782 join(49155..49294,49403..49563,49601..49689,50054..50353) VI 1 NT_166539.1 hypothetical protein 50353 84590782 An04g00280 Aspergillus niger hypothetical protein XP_059600417.1 49155 D 5061 CDS An04g00290 84590783 complement(join(50805..50913,51020..51147,51337..51411)) VI 1 NT_166539.1 hypothetical protein 51411 84590783 An04g00290 Aspergillus niger hypothetical protein XP_059600418.1 50805 R 5061 CDS An04g00300 84590784 complement(join(53118..56187,56393..56403)) VI 1 NT_166539.1 Title: weak similarity to ascites sialoglycoprotein 1 - Rattus norvegicus; uncharacterized protein 56403 84590784 An04g00300 Aspergillus niger uncharacterized protein XP_059600419.1 53118 R 5061 CDS An04g00310 84590785 join(57194..57201,57537..57603,57644..57694,57778..57794,58069..58213,58603..58638) VI 1 NT_166539.1 Title: questionable ORF; uncharacterized protein 58638 84590785 An04g00310 Aspergillus niger uncharacterized protein XP_059600420.1 57194 D 5061 CDS An04g00320 84590786 complement(join(59190..59392,59510..59565,59652..59718,59820..59870,59959..60179,60270..60448)) VI 1 NT_166539.1 hypothetical protein 60448 84590786 An04g00320 Aspergillus niger hypothetical protein XP_059600421.1 59190 R 5061 CDS An04g00330 84590787 complement(join(61248..61304,61351..61446,61605..61640)) VI 1 NT_166539.1 hypothetical protein 61640 84590787 An04g00330 Aspergillus niger hypothetical protein XP_059600422.1 61248 R 5061 CDS An04g00340 4990434 join(62295..62491,62586..62882,62968..64111) VI 1 NT_166539.1 Function: in S. cerevisiae ITR2 is a permease importing inositol from the external environment into the cytosol.; Similarity: in S. cerevisiae ITR1 is strongly related to ITR2, an inositol permease which is expressed at much lower levels.; Title: strong similarity to myo-inositol transport protein Itr2 - Saccharomyces cerevisiae; plasma membrane; See PMID 7768846; See PMID 7934871; See PMID 2040626; uncharacterized protein 64111 4990434 An04g00340 Aspergillus niger uncharacterized protein XP_001401397.1 62295 D 5061 CDS An04g00350 4990435 join(64909..65307,65360..65657,65725..65819,65879..66340) VI 1 NT_166539.1 Similarity: partial similarity to probable serine carboxypeptidase of Caenorhabditis elegans.; hypothetical protein 66340 4990435 An04g00350 Aspergillus niger hypothetical protein XP_001401398.3 64909 D 5061 CDS An04g00360 4990436 complement(join(66480..66804,66878..67287,67357..67387,67454..67569,67661..67702,67774..67776)) VI 1 NT_166539.1 Complex: in S. cerevisiae, Sec13p participates,together with the Sar1, Sec31, Sec23, and Sec24 proteins to the formation of the COPII coat, necessary for COPII vesicles formation.; Function: in S. cerevisiae, Sec13p is a cytoplasmic protein involved in release of transport vesicles from the ER. Sec13p is also involved in a post-Golgi trafficking step specific for the General Aminoacid Permease Gap1p.; Remark: identical to A. niger EST EMBLEST:BE759088.; Title: strong similarity to transport vesicle formation protein Sec13 - Saccharomyces cerevisiae; cytoplasm; See PMID 9568718; uncharacterized protein 67776 4990436 An04g00360 Aspergillus niger uncharacterized protein XP_001401399.1 66480 R 5061 CDS An04g00370 4990437 join(68322..68435,68485..69270,69381..69501,69620..69735) VI 1 NT_166539.1 Function: in Y. lipolytica, PEX20 is required for both the oligomerization of thiolase in the cytosol and its targeting to the peroxisome.; Localization: in Y. lipolytica, PEX20 is mostly cytosolic, whereas 4-8% is associated with peroxisomes.; Remark: peroxins are proteins required for peroxisome assembly.; Title: similarity to peroxin protein PEX20 -Yarrowia lipolytica; cytoplasm; See PMID 9679140; See PMID 11042200; uncharacterized protein 69735 4990437 An04g00370 Aspergillus niger uncharacterized protein XP_059600423.1 68322 D 5061 CDS An04g00380 84590788 join(70426..71034,71139..71186) VI 1 NT_166539.1 Remark: only partial weak similaritiy to some metallopeptidases (proteinases) of H. influenca.; hypothetical protein 71186 84590788 An04g00380 Aspergillus niger hypothetical protein XP_059600424.1 70426 D 5061 CDS An04g00390 4990439 complement(join(72609..72707,72763..72847,72910..73572,73723..73910,74007..74076,74181..74524)) VI 1 NT_166539.1 Complex: in S. cerevisiae, SFH1 interacts functionally and physically with an essential Snf2p paralog in a novel nucleosome-restructuring complex called RSC (for remodels the structure of chromatin).; Function: in S. cerevisiae, SFH1 is required for cell cycle progression.; Remark: in S. cerevisiae, SFH1 is a phosphoprotein which phosphorilation is regulated during the cell cycle.; Similarity: the protein shows strong homology to the functionally and evolutionary significant 200 amino acids long domain of the SNF5 regulatory protein family.; Title: strong similarity to chromatin-remodeling complex protein Sfh1 - Saccharomyces cerevisiae; nucleus; See PMID 9154831; uncharacterized protein 74524 4990439 An04g00390 Aspergillus niger uncharacterized protein XP_059600425.1 72609 R 5061 CDS An04g00400 4990440 complement(join(75423..75443,75497..75761,75835..76187,76284..76419,76483..76519,76588..76666)) VI 1 NT_166539.1 Function: in S. cerevisiae, the WHI2 gene is important for cell cycle arrest upon nutrient exhaustion,as WHI2 mutants continue to divide and become abnormally small when nutrients are depleted.; Title: similarity to growth regulation protein Whi2 - Saccharomyces cerevisiae; See PMID 3900284; See PMID 9202462; See PMID 2204679; uncharacterized protein 76666 4990440 An04g00400 Aspergillus niger uncharacterized protein XP_001401403.3 75423 R 5061 CDS An04g00410 4990441 complement(join(78019..79134,79197..80076,80159..80286)) VI 1 NT_166539.1 Catalytic activity: in R. norvegicus, the enzyme releases a n-terminal dipeptide from a peptide of four or more residues, with broad specificity.; Cofactor: in R. norvegicus, the protein binds one zinc ion.; Function: in R. norvegicus, the enzyme is a cytosoline-type peptidase that cleaves arg-arg-beta-naphthylamide with pH optimum of 9. 0; Regulation: in R. norvegicus, the enzyme is inhibited by thiol reagents.; Title: strong similarity to dipeptidyl peptidase III - Rattus norvegicus; See PMID 9425109; See PMID 10387075; uncharacterized protein 80286 4990441 An04g00410 Aspergillus niger uncharacterized protein XP_001401404.1 78019 R 5061 CDS An04g00420 4990442 complement(join(80998..82029,82120..82316,82365..83802)) VI 1 NT_166539.1 Remark: involvement of Ca2+ in enhancing the MAP kinase signaling cascade in plants.; Similarity: also similarities to membrane-associated form of proteophosphoglycans.; Title: similarity to MAP kinase homolog WCK-1 -Triticum aestivum; uncharacterized protein 83802 4990442 An04g00420 Aspergillus niger uncharacterized protein XP_059600426.1 80998 R 5061 CDS An04g00430 4990443 join(84757..84985,85047..85344,85404..86102,86162..86174) VI 1 NT_166539.1 Catalytic activity: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.; Cofactor: Pyridoxal-phosphate.; Function: BAT2 of S. cerevisiae catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine, and it is involved in cell cycle regulation.; Localization: in S. cerevisiae BAT2 is located in the cytoplasm.; Regulation: in S. cerevisiae BAT2 is highly expressed during stationary phase and down-regulated during logarithmic phase of growth.; Similarity: in S. cerevisiae a close homologue,called BAT1, exhert the same catalytic activity in the mitochondria.; Title: strong similarity to branched-chain-amino-acid aminotransferase Bat2 -Saccharomyces cerevisiae; cytoplasm; See PMID 8702755; See PMID 8798704; uncharacterized protein 86174 4990443 An04g00430 Aspergillus niger uncharacterized protein XP_001401406.1 84757 D 5061 CDS An04g00433 84590789 complement(86401..86787) VI 1 NT_166539.1 hypothetical protein 86787 84590789 An04g00433 Aspergillus niger hypothetical protein XP_059600427.1 86401 R 5061 CDS An04g00440 84590790 complement(join(87651..87826,87901..88044,88248..88321,88442..88533)) VI 1 NT_166539.1 Remark: partial weak similarities to IgE-binding protein of mouse and carbohydrate binding proteins of other organisms.; hypothetical protein 88533 84590790 An04g00440 Aspergillus niger hypothetical protein XP_059600428.1 87651 R 5061 CDS An04g00450 84590791 complement(join(89591..89647,89737..89883)) VI 1 NT_166539.1 hypothetical protein 89883 84590791 An04g00450 Aspergillus niger hypothetical protein XP_059600429.1 89591 R 5061 CDS An04g00460 84590792 join(92456..92512,92604..92642) VI 1 NT_166539.1 hypothetical protein 92642 84590792 An04g00460 Aspergillus niger hypothetical protein XP_059600430.1 92456 D 5061 CDS An04g00470 84590793 join(95835..95843,95888..95992,96040..96466,96527..96567,96750..96756,96889..97162,97307..97349,97508..97537,97585..97630,97815..97837,98047..98263,98490..98527) VI 1 NT_166539.1 Title: weak similarity to hypothetical protein C50F2.2 - Caenorhabditis elegans; uncharacterized protein 98527 84590793 An04g00470 Aspergillus niger uncharacterized protein XP_059600431.1 95835 D 5061 CDS An04g00480 4990449 complement(join(99164..99756,99826..99997)) VI 1 NT_166539.1 Similarity: the ORF encoded protein shows interesting domain homology (bZIP domain) to the regulator of cyclic peptide biosynthesis and pathogenicity TOXEp from Cochliobolus carbonum, Pubmed 9894916.; Title: similarity to hypothetical protein CAE85614.1 - Neurospora crassa; uncharacterized protein 99997 4990449 An04g00480 Aspergillus niger uncharacterized protein XP_001401412.3 99164 R 5061 CDS An04g00490 4990450 complement(103283..104374) VI 1 NT_166539.1 Complex: the S. cerevisiae casein kinase II (CKII) is composed of two catalytic and two regulatory subunits encoded by the CKA1, CKA2, CKB1, and CKB2 genes.; Function: the S. cerevisiae Ckb1 protein is component of the casein kinase II (CKII). Analysis of null and conditional alleles of the CKII encoding genes identifies a requirement for CKII in at least four biological processes: flocculation (which may reflect an effect on gene expression), cell cycle progression, cell polarity, and ion homeostasis.; Remark: alternate name for S. cerevisiae Ckb1: YGL019W.; Title: strong similarity to regulator subunit of the casein kinase II Ckb1 - Saccharomyces cerevisiae; See PMID 9427841; See PMID 10515937; See PMID 7737972; uncharacterized protein 104374 4990450 An04g00490 Aspergillus niger uncharacterized protein XP_001401413.1 103283 R 5061 CDS An04g00500 4990451 complement(join(105344..106318,106375..106626,106679..107418,107499..107544,107623..107699,107732..107963)) VI 1 NT_166539.1 Function: PrnA is a transcriptional activator of the fungal binuclear zinc cluster type that mediates proline induction of genes involved in proline utilization as sole nitrogen and/or carbon source in A. nidulans.; Title: similarity to transcription activator prnA -Aspergillus nidulans; nucleus; See PMID 9622360; See PMID 10788322; uncharacterized protein 107963 4990451 An04g00500 Aspergillus niger uncharacterized protein XP_059600432.1 105344 R 5061 CDS An04g00510 4990452 108631..109596 VI 1 NT_166539.1 Title: similarity to hypothetical protein CAA99769.1 - Caenorhabditis elegans; uncharacterized protein 109596 4990452 An04g00510 Aspergillus niger uncharacterized protein XP_001401415.3 108631 D 5061 CDS An04g00520 84590794 join(109707..109772,109883..110599) VI 1 NT_166539.1 Title: similarity to hypothetical protein EAA60488.1 - Aspergillus nidulans; uncharacterized protein 110599 84590794 An04g00520 Aspergillus niger uncharacterized protein XP_059600433.1 109707 D 5061 CDS An04g00530 4990454 complement(join(110881..110920,110974..111350,111407..112142,112212..112434,112981..113329)) VI 1 NT_166539.1 Title: strong similarity to proline permease prnB -Aspergillus nidulans; plasma membrane; See PMID 2664423; See PMID 7590163; uncharacterized protein 113329 4990454 An04g00530 Aspergillus niger uncharacterized protein XP_059600434.1 110881 R 5061 CDS An04g00540 84590795 join(113840..113884,113967..114242) VI 1 NT_166539.1 hypothetical protein 114242 84590795 An04g00540 Aspergillus niger hypothetical protein XP_059600435.1 113840 D 5061 CDS An04g00550 84590796 complement(join(114718..114909,115093..115302)) VI 1 NT_166539.1 Title: strong similarity to EST an_1834 -Aspergillus niger; uncharacterized protein 115302 84590796 An04g00550 Aspergillus niger uncharacterized protein XP_059600436.1 114718 R 5061 CDS An04g00560 4990457 join(115782..115880,115988..116108,116185..116280,116361..116539) VI 1 NT_166539.1 Title: similarity to steroid membrane binding protein from patent WO9810291-A1 - Homo sapiens; uncharacterized protein 116539 4990457 An04g00560 Aspergillus niger uncharacterized protein XP_059600437.1 115782 D 5061 CDS An04g00570 4990458 complement(116769..118937) VI 1 NT_166539.1 Function: the S. cerevisiae Nop77 protein is required for ribosomal RNA biogenesis. It probably functions in the processing of 27S rRNA to produce mature 25S rRNA and interacts with Nop1.; Remark: alternate names for S. cerevisiae Nop77: Nop4 or YPL043W.; Title: strong similarity to essential nucleolar protein Nop77 - Saccharomyces cerevisiae; nucleus; See PMID 8039506; uncharacterized protein 118937 4990458 An04g00570 Aspergillus niger uncharacterized protein XP_001401421.1 116769 R 5061 CDS An04g00580 4990459 119631..120614 VI 1 NT_166539.1 Function:the S. pombe Swi10 is involved in termination of copy-synthesis during mating-type switching. It is also involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Along with S. pombe Rad16 it forms an endonuclease that specifically degrades single-stranded DNA.; Similarity: the ORF encoded protein and S. pombe Swi10 belong to the ERCC1/RAD10/SWI10 family.; Title: strong similarity to mating-type switching protein swi10p - Schizosaccharomyces pombe; nucleus; See PMID 9207030; See PMID 1475195; uncharacterized protein 120614 4990459 An04g00580 Aspergillus niger uncharacterized protein XP_001401422.1 119631 D 5061 CDS An04g00590 4990460 join(121782..122460,122570..122856,122910..123034,123084..124002) VI 1 NT_166539.1 Title: weak similarity to nuclear matrix transcription factor MINT - Mus musculus; uncharacterized protein 124002 4990460 An04g00590 Aspergillus niger uncharacterized protein XP_001401423.1 121782 D 5061 CDS An04g00600 4990461 complement(join(125291..125642,125739..125884,125938..126225,126284..126594,126716..126851)) VI 1 NT_166539.1 Function: S. cerevisiae Lag1 protein is involved in the yeast cell aging process. A deletion of the LAG1 gene results in a pronounced increase (approximately 50%) in mean and in maximum life span.; Remark: alternate name for S. cerevisiae Lag1: YKL008c.; Title: strong similarity to hypothetical ER-to-Golgi transporter Lag1 - Saccharomyces cerevisiae; See PMID 8195187; uncharacterized protein 126851 4990461 An04g00600 Aspergillus niger uncharacterized protein XP_059600438.1 125291 R 5061 CDS An04g00610 4990462 complement(join(128423..128702,128755..>130499)) VI 1 NT_166539.1 Catalytic activity: (R)-mevalonate + CoA + 2 NADP(+) <=> (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.; Function: the 3-Hydroxy-3-methylglutaryl-CoA reductase (Hmg1) from Schizosaccharomyces pombe is the first specific enzyme of the isoprenoid pathway, which leads to several classes of primary and secondary metabolites such as sterols, quinones etc.; Pathway: isoprenoid biosynthesis.; Remark: N-terminally truncated ORF due to the end of contig.; Title: strong similarity to hydroxymethylglutaryl-coenzyme A reductase hmg1p -Schizosaccharomyces pombe [truncated ORF]; See PMID 8896278; uncharacterized protein 130499 4990462 An04g00610 Aspergillus niger uncharacterized protein XP_059600439.1 128423 R 5061 CDS An04g00620 84590797 complement(join(<130649..131031,131102..131195)) VI 1 NT_166539.1 Remark: C-terminally truncated ORF due to end of contig.; Title: strong similarity to hydroxymethylglutaryl-coenzyme A reductase from patent EP1149919-A2 - Penicillium citrinum [truncated ORF]; uncharacterized protein 131195 84590797 An04g00620 Aspergillus niger uncharacterized protein XP_059600440.1 130649 R 5061 CDS An04g00630 10098347 complement(join(132358..133552,134121..134383,134441..134682,134739..134925)) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein CAC28557.1 - Neurospora crassa; uncharacterized protein 134925 10098347 An04g00630 Aspergillus niger uncharacterized protein XP_003188650.2 132358 R 5061 CDS An04g00640 4990465 join(135730..135811,135959..136127,136602..136946,137029..137293,137353..137587,137655..137784,137835..140022) VI 1 NT_166539.1 Title: similarity to hypothetical ATP/GTP-binding protein SCC61A.02 - Streptomyces coelicolor; uncharacterized protein 140022 4990465 An04g00640 Aspergillus niger uncharacterized protein XP_059600441.1 135730 D 5061 CDS An04g00650 4990466 join(140945..141007,141070..141162) VI 1 NT_166539.1 hypothetical protein 141162 4990466 An04g00650 Aspergillus niger hypothetical protein XP_001401429.3 140945 D 5061 CDS An04g00660 4990467 complement(141640..142779) VI 1 NT_166539.1 Similarity: the ORF shows weak similarity to another A. niger protein. The similarity between the two proteins is restricted to a stretch of about 200 amino acids.; Title: strong similarity to hypothetical protein EAA60502.1 - Aspergillus nidulans; uncharacterized protein 142779 4990467 An04g00660 Aspergillus niger uncharacterized protein XP_001401430.1 141640 R 5061 CDS An04g00670 4990468 join(143180..143266,143381..143567,143669..143985) VI 1 NT_166539.1 Title: strong similarity to hypothetical coiled-coil protein similar to human congenital heart disease protein CAC05252.1 - Schizosaccharomyces pombe; uncharacterized protein 143985 4990468 An04g00670 Aspergillus niger uncharacterized protein XP_001401431.1 143180 D 5061 CDS An04g00680 4990469 complement(join(145179..145911,145969..146605,146676..146709)) VI 1 NT_166539.1 Function: gar2 is required for 18S rRNA and 40S ribosomal subunit accumulation.; Title: similarity to nucleolar protein gar2p -Schizosaccharomyces pombe; uncharacterized protein 146709 4990469 An04g00680 Aspergillus niger uncharacterized protein XP_001401432.1 145179 R 5061 CDS An04g00690 4990470 join(147214..147300,147351..147462,147514..147550,147594..147681,147910..148029) VI 1 NT_166539.1 hypothetical protein 148029 4990470 An04g00690 Aspergillus niger hypothetical protein XP_059600442.1 147214 D 5061 CDS An04g00700 84590798 join(150397..150433,150516..150913) VI 1 NT_166539.1 hypothetical protein 150913 84590798 An04g00700 Aspergillus niger hypothetical protein XP_059600443.1 150397 D 5061 CDS An04g00710 84590799 complement(join(155184..155519,155584..155727)) VI 1 NT_166539.1 Title: weak similarity to hypothetical protein CAC28773.2 - Neurospora crassa; uncharacterized protein 155727 84590799 An04g00710 Aspergillus niger uncharacterized protein XP_059600444.1 155184 R 5061 CDS An04g00720 4990473 complement(join(156885..158165,158264..158668)) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein encoded by An09g02950 - Aspergillus niger; uncharacterized protein 158668 4990473 An04g00720 Aspergillus niger uncharacterized protein XP_059600445.1 156885 R 5061 CDS An04g00730 84590800 join(158874..159667,159701..160324,160603..160885) VI 1 NT_166539.1 Title: similarity to hypothetical protein B24P7.50 -Neurospora crassa; uncharacterized protein 160885 84590800 An04g00730 Aspergillus niger uncharacterized protein XP_059600446.1 158874 D 5061 CDS An04g00740 4990475 complement(join(161562..162444,162494..162987)) VI 1 NT_166539.1 Title: strong similarity to sterol carrier protein-X/sterol carrier protein-2 SCP2 - Homo sapiens; See PMID 7654720; See PMID 10856712; uncharacterized protein 162987 4990475 An04g00740 Aspergillus niger uncharacterized protein XP_001401438.1 161562 R 5061 CDS An04g00747 84590801 join(164790..164966,165147..165284,165422..165454) VI 1 NT_166539.1 hypothetical protein 165454 84590801 An04g00747 Aspergillus niger hypothetical protein XP_059600447.1 164790 D 5061 CDS An04g00750 4990477 join(165872..166056,166117..166274,166334..166552,166603..166931,166980..167088,167230..167327) VI 1 NT_166539.1 Title: similarity to hypothetical mitochondrial carrier protein SPBC29A3.11c - Schizosaccharomyces pombe; uncharacterized protein 167327 4990477 An04g00750 Aspergillus niger uncharacterized protein XP_059600448.1 165872 D 5061 CDS An04g00760 4990478 join(167715..167722,167774..168011,168057..168111,168164..169058,169102..169676,169720..170122,170171..170462) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein palA - Aspergillus nidulans; uncharacterized protein 170462 4990478 An04g00760 Aspergillus niger uncharacterized protein XP_001401441.1 167715 D 5061 CDS An04g00770 84590802 complement(join(170658..172285,172356..172524)) VI 1 NT_166539.1 Title: weak similarity to hypothetical protein WimA - Dictyostelium discoideum; uncharacterized protein 172524 84590802 An04g00770 Aspergillus niger uncharacterized protein XP_059600449.1 170658 R 5061 CDS An04g00780 4990480 complement(join(172836..173328,173375..174430,174460..174594,174639..175096,175210..175308)) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein CAD11370.1 - Neurospora crassa; uncharacterized protein 175308 4990480 An04g00780 Aspergillus niger uncharacterized protein XP_059600450.1 172836 R 5061 CDS An04g00790 4990481 complement(join(176028..176075,176176..178236)) VI 1 NT_166539.1 Catalytic activity: 3-Dehydroquinate = 3-Dehydroshikimate + H2O.; Catalytic activity: Shikimate + NADP+ = 5-Dehydroshikimate + NADPH.; Function: aroM from A. nidulans catalyses 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.; Function: because N-terminal sequences are missing it is likely that only the 3-DEHYDROQUINASE and SHIKIMATE DEHYDROGENASE activities are present.; Remark: the protein is N-terminal significant shorter than the matching protein of A. nidulans.; Title: strong similarity to multifunctional protein aroM - Aspergillus nidulans; See PMID 1648168; See PMID 1849480; See PMID 8257437; See PMID 8383607; uncharacterized protein 178236 4990481 An04g00790 Aspergillus niger uncharacterized protein XP_001401444.3 176028 R 5061 CDS An04g00800 4990482 complement(join(180205..180602,180694..180948,181002..183323,183413..184052)) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein B13I18.170 - Neurospora crassa; uncharacterized protein 184052 4990482 An04g00800 Aspergillus niger uncharacterized protein XP_059600451.1 180205 R 5061 CDS An04g00810 84590803 join(185416..185560,185673..186037) VI 1 NT_166539.1 hypothetical protein 186037 84590803 An04g00810 Aspergillus niger hypothetical protein XP_059600452.1 185416 D 5061 CDS An04g00820 4990484 complement(join(189080..189347,189560..189867,189918..190280)) VI 1 NT_166539.1 Title: similarity to hypothetical protein B1D1.40 -Neurospora crassa; uncharacterized protein 190280 4990484 An04g00820 Aspergillus niger uncharacterized protein XP_059600453.1 189080 R 5061 CDS An04g00830 4990485 join(190760..190909,191114..191592,191650..191816,191923..191978,192035..192273,192328..192469) VI 1 NT_166539.1 Title: similarity to hypothetical protein T22P22.10 - Arabidopsis thaliana; uncharacterized protein 192469 4990485 An04g00830 Aspergillus niger uncharacterized protein XP_059600454.1 190760 D 5061 CDS An04g00840 4990486 complement(193225..194679) VI 1 NT_166539.1 Title: similarity to hypothetical trfA like protein - Neurospora crassa; uncharacterized protein 194679 4990486 An04g00840 Aspergillus niger uncharacterized protein XP_001401449.1 193225 R 5061 CDS An04g00850 4990487 join(196241..196520,196644..>196738) VI 1 NT_166539.1 Remark: C-terminal truncated due to contig end.; Title: similarity to hypothetical positive sulphur transcription regulator metR - Aspergillus nidulans [truncated ORF]; uncharacterized protein 196738 4990487 An04g00850 Aspergillus niger uncharacterized protein XP_059600455.1 196241 D 5061 CDS An04g00860 4990488 complement(join(<196840..198023,198095..198128)) VI 1 NT_166539.1 Remark: truncated ORF due to contig border.; Title: strong similarity to hypothetical protein CAC18137.1 - Neurospora crassa [truncated ORF]; uncharacterized protein 198128 4990488 An04g00860 Aspergillus niger uncharacterized protein XP_001401451.3 196840 R 5061 CDS An04g00870 4990489 join(199642..199888,199938..202517,202600..202635,202673..202719) VI 1 NT_166539.1 Function: links among mismatch repair, genetic recombination, and chromosome synapsis in meiosis.; Function: yeast MLH3 and murine PMS2 are involved in DNA mismatch repair.; Similarity: shows no similarity in the central part to MLH3 from S. cerevisiae but show similarity almost over the complete length to murine protein PMS2.; Title: similarity to insertion and deletion mismatch repair protein Mlh3 - Saccharomyces cerevisiae; nucleus; See PMID 9770499; uncharacterized protein 202719 4990489 An04g00870 Aspergillus niger uncharacterized protein XP_001401452.3 199642 D 5061 CDS An04g00880 4990490 complement(join(203421..206390,206446..206961)) VI 1 NT_166539.1 Function: biochemical analysis has shown that Csc25 of C. albicans activates the Ras/adenylyl cyclase pathway in S. cerevisiae at a rate two to three times faster than Cdc25 of S. cerevisiae, under the same conditions.; Similarity: restricted to carboxyterminus as usual for the proteins of the CDC25 family; Similarity: the size of proteins of this family ranges from 309 residues (LTE1) to 1596 residues (sos).; Title: similarity to cell division cycle protein CDC25 - Candida albicans; See PMID 8477693; uncharacterized protein 206961 4990490 An04g00880 Aspergillus niger uncharacterized protein XP_001401453.1 203421 R 5061 CDS An04g00890 84590804 complement(join(209481..209519,209561..209576,209617..209633,209925..210110,210175..210346,210376..210417,210550..210569)) VI 1 NT_166539.1 hypothetical protein 210569 84590804 An04g00890 Aspergillus niger hypothetical protein XP_059600456.1 209481 R 5061 CDS An04g00900 4990492 join(217775..217878,217972..218025,218108..218127,218401..218441,218856..218878,218921..218942,219093..219096,219202..219224,219519..219930,219994..220251,220308..220424,220484..220567,220617..220787,220841..221435,221494..224344) VI 1 NT_166539.1 Function: co-expression of het-e and het-c leads to cell death.; Function: het-e1 of P. anserina is responsible for vegetative incompatibility.; Remark: het-e1 of P. anserina shows two sequence motifs, a GTP-binding domain and a repeated region that shares similarity with that of the beta-transducin.; Remark: the reactivity of the HET-E protein depends on two functional elements, a GTP-binding domain and several WD40 repeats.; Similarity: shows only partial similarity to het-e1.; Title: weak similarity to beta transducin-like protein het-e1 - Podospora anserina; See PMID 7557402; See PMID 9435787; See PMID 10875280; See PMID 10974123; uncharacterized protein 224344 4990492 An04g00900 Aspergillus niger uncharacterized protein XP_059600457.1 217775 D 5061 CDS An04g00910 4990493 complement(join(224977..226156,226260..226675,226723..227235,227283..227345,227395..227645,227696..228314)) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein EAA60294.1 - Aspergillus nidulans; uncharacterized protein 228314 4990493 An04g00910 Aspergillus niger uncharacterized protein XP_059600458.1 224977 R 5061 CDS An04g00920 84590805 join(228871..229045,229137..229165) VI 1 NT_166539.1 hypothetical protein 229165 84590805 An04g00920 Aspergillus niger hypothetical protein XP_059600459.1 228871 D 5061 CDS An04g00930 4990495 join(237038..237177,237359..238061) VI 1 NT_166539.1 Function: ilp is an apoptosis inhibitor.; Similarity: show only partial similarity to ilp.; Title: weak similarity to apoptosis inhibitor IAP homolog ilp - Homo sapiens; uncharacterized protein 238061 4990495 An04g00930 Aspergillus niger uncharacterized protein XP_001401458.3 237038 D 5061 CDS An04g00940 84590806 complement(join(238474..238518,238674..238756,238808..238921,239035..239057,239350..>239408)) VI 1 NT_166539.1 Remark: truncated ORF due to contig border.; hypothetical protein [truncated ORF] 239408 84590806 An04g00940 Aspergillus niger hypothetical protein [truncated ORF] XP_059600460.1 238474 R 5061 CDS An04g00950 4990498 join(239659..239802,239845..240567) VI 1 NT_166539.1 Function: M. grisea Pth11 is a pathogenicity gene.; Function: M. grisea Pth11p likely is involved in host surface recognition.; Function: M. grisea pth11 mutants of strain 4091-5-8 are nonpathogenic due to a defect in appressorium differentiation.; Localization: in M. grisea a Pth11-green fluorescent protein fusion localised to the cell membrane and vacuoles.; Similarity: similarity is the predicted A. niger protein and the N-terminal region of M. grisea Pth11 which is 300 aa longer.; Title: weak similarity to membrane protein Pth11 -Magnaporthe grisea; See PMID 10521529; uncharacterized protein 240567 4990498 An04g00950 Aspergillus niger uncharacterized protein XP_059600461.1 239659 D 5061 CDS An04g00960 84590807 241000..242499 VI 1 NT_166539.1 Function: expression of B. abortus gluP functionally complements E. coli strains lacking either glucose or galactose transport systems.; Similarity: B. abortus gluP is a member of the major facilitator superfamily.; Title: strong similarity to glucose/galactose transporter gluP - Brucella abortus; See PMID 9168605; uncharacterized protein 242499 84590807 An04g00960 Aspergillus niger uncharacterized protein XP_059600462.1 241000 D 5061 CDS An04g00970 84590808 243057..243845 VI 1 NT_166539.1 Title: similarity to hypothetical transmembrane protein orf375 - Bradyrhizobium japonicum; uncharacterized protein 243845 84590808 An04g00970 Aspergillus niger uncharacterized protein XP_059600463.1 243057 D 5061 CDS An04g00980 4990500 complement(join(244898..245434,245498..245727,245787..246148,246184..246380)) VI 1 NT_166539.1 Function: B. laterosporus glutaryl 7-ACA acylase converts 7 beta-(4-carboxybutanamido)cephalosporanic acid (glutaryl 7-ACA) to 7-amino cephalosporanic acid (7-ACA),an intermediate of antibiotica synthesis.; Localization: in B. subtilis extracellular excretion of glutaryl 7-ACA acylase was observed; Title: similarity to glutaryl 7-ACA acylase -Bacillus laterosporus; See PMID 1744041; uncharacterized protein 246380 4990500 An04g00980 Aspergillus niger uncharacterized protein XP_059600464.1 244898 R 5061 CDS An04g00990 4990501 complement(join(247732..248505,248564..249126,249191..249236)) VI 1 NT_166539.1 Catalytic activity: glutamate dehydrogenases convert L-glutamate + H(2)O + NADP(+) to 2-oxoglutarate + NH(3) + NADPH.; Function: A. niger gdhA is a NADP-dependent glutamate dehydrogenases.; Gene-ID: gdhA; Induction: in A. niger very high expression levels of the gdhA gene were observed in media with ammonium or asparagine as the nitrogen source.; Repression: in A. niger glutamic acid repressed transcription of the gdhA gene.; See PMID 9683675; NADP-dependent glutamate dehydrogenase gdhA from patent WO9951756-A-Aspergillus niger 249236 gdhA 4990501 gdhA Aspergillus niger NADP-dependent glutamate dehydrogenase gdhA from patent WO9951756-A-Aspergillus niger XP_001401464.1 247732 R 5061 CDS An04g01000 84590809 join(249369..249522,249598..249651,249698..249806,249995..250094,250264..250445,250777..250966) VI 1 NT_166539.1 Remark: the blastn similarity to gdh of A. awamori is restricted to a noncoding 5'-flanking region of the gene.; hypothetical protein 250966 84590809 An04g01000 Aspergillus niger hypothetical protein XP_059600465.1 249369 D 5061 CDS An04g01010 84590810 join(252582..252584,252785..252914,253130..253368) VI 1 NT_166539.1 hypothetical protein 253368 84590810 An04g01010 Aspergillus niger hypothetical protein XP_059600466.1 252582 D 5061 CDS An04g01020 84590811 join(253417..253539,253640..253785,253869..253946,254024..254362,254709..255114) VI 1 NT_166539.1 Title: weak similarity to hypothetical helicase-like transcription factor M03C11.8 - Caenorhabditis elegans; uncharacterized protein 255114 84590811 An04g01020 Aspergillus niger uncharacterized protein XP_059600467.1 253417 D 5061 CDS An04g01030 84590812 join(255936..255948,255996..256237) VI 1 NT_166539.1 hypothetical protein 256237 84590812 An04g01030 Aspergillus niger hypothetical protein XP_059600468.1 255936 D 5061 CDS An04g01040 84590813 join(257049..257145,257396..257720,257935..258094) VI 1 NT_166539.1 hypothetical protein 258094 84590813 An04g01040 Aspergillus niger hypothetical protein XP_059600469.1 257049 D 5061 CDS An04g01050 84590814 complement(join(258840..258941,258996..259097,259226..259339)) VI 1 NT_166539.1 hypothetical protein 259339 84590814 An04g01050 Aspergillus niger hypothetical protein XP_059600470.1 258840 R 5061 CDS An04g01060 84590815 join(260818..260901,261456..261719) VI 1 NT_166539.1 Title: weak similarity to olfactory receptor OR5D4 -Homo sapiens; See PMID 9787077; uncharacterized protein 261719 84590815 An04g01060 Aspergillus niger uncharacterized protein XP_059600471.1 260818 D 5061 CDS An04g01070 4990509 join(262485..262563,262691..262803) VI 1 NT_166539.1 Remark: EcoRI adaptors were later ligated to polished ends.; Remark: EcoRI-XhoI-digested cDNA was ligated with EcoRI-XhoI-digested pYES2 (Invitrogen Corp).; Remark: Synthesis was primed with oligo(dT) primer/XhoI-linker.; Remark: This vector permits expression of our library in yeast.; Remark: cDNA was synthesized with ZAP kit (Stratagene) using poly(A)+ RNA isolated from Aspergillus niger grown in both complete and minimal media.; Title: strong similarity to EST an_2651 -Aspergillus niger; uncharacterized protein 262803 4990509 An04g01070 Aspergillus niger uncharacterized protein XP_001401472.1 262485 D 5061 CDS An04g01080 4990510 complement(join(263052..264531,264581..265521,265575..265732,265843..265861)) VI 1 NT_166539.1 Catalytic activity: 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O = ribonucleoside diphosphate + reduced thioredoxin.; Remark: Patentmatch against protein in Geneseqprot DB, AC W41764.; Title: strong similarity to ribonucleotide reductase from patent JP10014582-A - Homo sapiens; uncharacterized protein 265861 4990510 An04g01080 Aspergillus niger uncharacterized protein XP_001401473.1 263052 R 5061 CDS An04g01090 4990511 complement(join(266580..266827,266892..267040,267100..267197)) VI 1 NT_166539.1 Remark: similarities correspond to multiple S-repeats.; Title: weak similarity to proteophosphoglycan ppg1 -Leishmania major; See PMID 10531342; uncharacterized protein 267197 4990511 An04g01090 Aspergillus niger uncharacterized protein XP_001401474.1 266580 R 5061 CDS An04g01100 4990512 complement(join(268891..269561,269643..269682)) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein SPAC227.14 - Schizosaccharomyces pombe; uncharacterized protein 269682 4990512 An04g01100 Aspergillus niger uncharacterized protein XP_001401475.1 268891 R 5061 CDS An04g01110 4990513 complement(join(270573..271866,271981..271991)) VI 1 NT_166539.1 Title: similarity to hypothetical protein 12F11.170 - Neurospora crassa; uncharacterized protein 271991 4990513 An04g01110 Aspergillus niger uncharacterized protein XP_001401476.1 270573 R 5061 CDS An04g01120 4990514 272803..274053 VI 1 NT_166539.1 Catalytic activity: ATP + Tetrahydrofolyl-[Glu](n) + L-Glutamate = ADP + Orthophosphate + Tetrahydrofolyl-[Glu](n+1).; Remark: Mutant yeast cells bearing a fol3 mutation require folinic acid for growth and have no dihydrofolate synthetase activity.; Title: similarity to folylpolyglutamate synthase Fol3 - Saccharomyces cerevisiae; See PMID 10799479; uncharacterized protein 274053 4990514 An04g01120 Aspergillus niger uncharacterized protein XP_001401477.1 272803 D 5061 CDS An04g01130 4990515 join(274925..275101,275161..275295,275355..275384,275441..275505,275561..275993,276043..276834,276889..277782,277831..278035,278085..278535,278587..279415) VI 1 NT_166539.1 Function: the protein kinase CDC7 of S. pombe is essential for septum formation and cell division.; Localization: Cdc7p shows no discrete localization during interphase, but early in mitosis it associates with both spindle pole bodies and, as the spindle extends, is seen on only one pole of the spindle during anaphase B. Spg1p activity is required for localization of Cdc7p in vivo but not for its kinase activity in vitro.; Remark: Cdc7p kinase and the Spg1p GTPase, with which it interacts, play a central role in signaling the initiation of septum formation.; Remark: overexpression of p120cdc7 causes cell cycle arrest; cells complete mitosis and then undergo multiple rounds of septum formation without cell cleavage.; Title: strong similarity to protein kinase cdc7p -Schizosaccharomyces pombe; See PMID 8039497; See PMID 9420333; uncharacterized protein 279415 4990515 An04g01130 Aspergillus niger uncharacterized protein XP_001401478.1 274925 D 5061 CDS An04g01140 4990516 complement(join(279760..280125,280173..280315,280365..281133)) VI 1 NT_166539.1 Catalytic activity: 6-carboxyhexanoyl-CoA + L-alanine <=> 8-amino-7-oxononanoate + CoA + CO(2).; Cofactor: Pyridoxal-phosphate.; Pathway: biotin biosynthesis.; Title: strong similarity to 8-amino-7-oxononanoate synthase/KAPA synthase BioF - Kurthia sp.; See PMID 11255013; uncharacterized protein 281133 4990516 An04g01140 Aspergillus niger uncharacterized protein XP_001401479.1 279760 R 5061 CDS An04g01150 4990517 282326..285379 VI 1 NT_166539.1 Pathway: myxalamid biosynthesis.; Remark: Myxalamids are polyketide structures with incorporated amino acids produced by myxobacteria. This class of secondary metabolites (epothilons, myxothiazols and myxalamids) often are effective inhibitors of the electron transport via the respiratory chain.; Title: strong similarity to nonribosomal peptide synthase MxaA - Stigmatella aurantiaca; See PMID 11182319; uncharacterized protein 285379 4990517 An04g01150 Aspergillus niger uncharacterized protein XP_059600472.1 282326 D 5061 CDS An04g01160 4990518 join(287049..287491,287565..288169,288229..288801,288861..289108) VI 1 NT_166539.1 Title: strong similarity to hypothetical ABC transporter SPBC15C4.02 - Schizosaccharomyces pombe; uncharacterized protein 289108 4990518 An04g01160 Aspergillus niger uncharacterized protein XP_001401481.1 287049 D 5061 CDS An04g01170 4990519 complement(join(290498..290655,290739..291005,291143..291166,291235..291382)) VI 1 NT_166539.1 Remark: alternate names for S. cerevisiae Isu2: Nua2, YOR226c.; Remark: deletion of either ISU1 or ISU2 results in increased accumulation of iron within the mitochondria,loss of activity of the [4Fe-4S] aconitase enzyme, and suppression of oxidative damage in cells lacking cytosolic copper/zinc superoxide dismutase.; Similarity: the ORF encoded protein and Isu2 from S. cerevisiae belong to the NifU-like protein family, NifU of nitrogen-fixing bacteria is involved in the synthesis of the Fe-S cluster of nitrogenase.; Title: strong similarity to protein probably involved in the synthesis of Fe-S clusters Isu2 -Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 10588895; See PMID 10468587; uncharacterized protein 291382 4990519 An04g01170 Aspergillus niger uncharacterized protein XP_001401482.3 290498 R 5061 CDS An04g01180 4990520 292430..292609 VI 1 NT_166539.1 hypothetical protein 292609 4990520 An04g01180 Aspergillus niger hypothetical protein XP_001401483.3 292430 D 5061 CDS An04g01190 4990521 complement(join(293696..294031,294095..294465,294519..294990)) VI 1 NT_166539.1 Remark: the human cDNA encoding the folate transporter/carrier complements the glycine auxotrophy of glyB cells (Chinese hamster ovary K1 subline that is deficient in the transport of folates into mitochondria) and reinstated folate accumulation in the mitochondria of transfected cells.; Title: similarity to folate transporter/carrier AAG37834.1 - Homo sapiens; localisation:mitochondrion; See PMID 10978331; uncharacterized protein 294990 4990521 An04g01190 Aspergillus niger uncharacterized protein XP_059600473.1 293696 R 5061 CDS An04g01200 4990522 join(295841..295956,296178..296286,296354..296407,296626..296715) VI 1 NT_166539.1 Catalytic activity: (Cytochrome bc1 complex) QH(2) + 2 ferricytochrome c <=> Q + 2 ferrocytochrome c.; Function: S. cerevisiae Qcr7 is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping.; Remark: alternate names for S. cerevisiae Qcr7: Cor4, Cro1, Ucr7, YDR529C.; Title: strong similarity to 14 kD subunit of ubiquinol--cytochrome c reductase Qcr7 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 10873857; See PMID 6319130; See PMID 9211895; uncharacterized protein 296715 4990522 An04g01200 Aspergillus niger uncharacterized protein XP_001401485.1 295841 D 5061 CDS An04g01210 4990523 complement(join(297127..297190,297249..297371,297425..298476)) VI 1 NT_166539.1 Function: the S. pombe DNA-3-methyladenine glycosidase I mag1 is involved in the base excision repair pathway. It cleaves the glycosylic bond linking potentially deleterious alkylated bases to the sugar phosphate backbone.; Title: similarity to DNA-3-methyladenine glycosidase I mag1p - Schizosaccharomyces pombe; nucleus; See PMID 10735851; See PMID 8921872; uncharacterized protein 298476 4990523 An04g01210 Aspergillus niger uncharacterized protein XP_001401486.1 297127 R 5061 CDS An04g01220 84590816 join(301307..301419,301451..301504,301802..301910,302014..302063,302344..302473,302689..303051) VI 1 NT_166539.1 hypothetical protein 303051 84590816 An04g01220 Aspergillus niger hypothetical protein XP_059600474.1 301307 D 5061 CDS An04g01230 4990525 join(303726..303786,303853..304693,304749..305052) VI 1 NT_166539.1 Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to hypothetical ECM33 homolog SPCC1223.12c - Schizosaccharomyces pombe; uncharacterized protein 305052 4990525 An04g01230 Aspergillus niger uncharacterized protein XP_001401488.1 303726 D 5061 CDS An04g01240 84590817 join(307377..307429,307593..307673,307746..307860,308083..308209,308270..308528,308630..308721,308825..308954,309192..309249,309358..309636) VI 1 NT_166539.1 hypothetical protein 309636 84590817 An04g01240 Aspergillus niger hypothetical protein XP_059600475.1 307377 D 5061 CDS An04g01250 4990527 join(313351..313385,313446..314547) VI 1 NT_166539.1 Remark: blastp matches due to repetitive stretches.; Similarity: the similarity between the ORF and the A. niger protein An08g11670 is restricted to a stretch of less than 200 amino acids.; Title: strong similarity to hypothetical protein encoded by An08g11670 - Aspergillus niger; uncharacterized protein 314547 4990527 An04g01250 Aspergillus niger uncharacterized protein XP_001401490.3 313351 D 5061 CDS An04g01260 4990528 join(316094..316266,316367..316998,317055..317102,317153..317535) VI 1 NT_166539.1 Complex: the complex consists of Mnn9p, Anp1p,Mnn11p, Hoc1p, and Mnn10p.; Function: Anp1p of S. cerevisiae is part of a complex in the cis-Golgi comprising 1,6-mannosyltransferase activity .; Function: this S. cerevisiae complex acts in succession to form and extend the mannan backbone of glycosylated proteins traversing the yeast Golgi.; Title: strong similarity to golgi alpha-1,6 mannosyltransferase subunit Anp1 - Saccharomyces cerevisiae; See PMID 11095735; uncharacterized protein 317535 4990528 An04g01260 Aspergillus niger uncharacterized protein XP_001401491.1 316094 D 5061 CDS An04g01270 10098293 join(318367..318443,318510..319023,319068..319130) VI 1 NT_166539.1 Similarity: the ORF shows similarity to another A. niger protein. The similarity, however, is restricted to a stretch of about 50 amino acids.; Title: weak similarity to hypothetical protein encoded by An11g03830 - Aspergillus niger; uncharacterized protein 319130 10098293 An04g01270 Aspergillus niger uncharacterized protein XP_059600476.1 318367 D 5061 CDS An04g01280 4990530 join(319973..320631,320689..320853,320915..321295,321335..321377,321443..321469,321478..>321735) VI 1 NT_166539.1 Catalytic activity: hydroxyphenylpyruvate dioxygenase catalyzes the conversion of 4-hydroxyphenylpyruvate + O(2) <=> homogentisate + CO(2); Pathway: hydroxyphenylpyruvate dioxygenase is involved in tyrosine catabolism.; Title: strong similarity to 4-hydroxyphenylpyruvate dioxygenase HPPD - Mycosphaerella graminicola [truncated ORF]; See PMID 9570125; uncharacterized protein 321735 4990530 An04g01280 Aspergillus niger uncharacterized protein XP_059600477.1 319973 D 5061 CDS An04g01290 4990531 complement(join(<321852..322825,322879..323053,323105..323284,323348..323735,323805..323812)) VI 1 NT_166539.1 Function: the S. cerevisiae Rad52 protein is involved in double-strand break repair and recombination.; Remark: C-terminally truncated ORF due to the end of contig.; Remark: N. crassa MUS11 = ncRad52.; Title: strong similarity to Rad52 homologue MUS11 -Neurospora crassa [truncated ORF]; See PMID 11129042; uncharacterized protein 323812 4990531 An04g01290 Aspergillus niger uncharacterized protein XP_059600478.1 321852 R 5061 CDS An04g01300 4990532 complement(join(324276..324782,324834..325165,325231..325315)) VI 1 NT_166539.1 Function: the chicken h-caldesmon is a actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). It stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. in muscle tissues, inhibits the actomyosin ATPase by binding to f-actin. this inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. It interacts with actin, myosin, two molecules of tropomyosin and with calmodulin and also plays an essential role during cellular mitosis and receptor capping.; Similarity: the ORF encoded protein shows strong similarity to the hypothetical proteins CG8209 (Drosophila), F23C8. 4 (C. elegans) and SPAC17C9. 11c (S. pombe).; Similarity: the similarity of the ORF encoded protein to h-caldesmon is mainly based on repetitive structures.; Title: similarity to calmodulin- and actin-binding protein h-caldesmon - Gallus gallus; See PMID 2803315; uncharacterized protein 325315 4990532 An04g01300 Aspergillus niger uncharacterized protein XP_001401495.1 324276 R 5061 CDS An04g01310 4990533 join(327297..327336,327407..327477,327544..327566,327636..327694,327756..327871,327927..328031,328098..328544) VI 1 NT_166539.1 Remark: the SCS2 gene from S. cerevisiae has been cloned as a suppressor of inositol auxotrophy of CSE1 and hac1/ire15 mutants. The disruption of the SCS2 gene causes yeast cells to exhibit inositol auxotrophy at temperatures of above 34 degrees C.; Title: similarity to protein involved in regulation of the inositol biosythesis Scs2 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 8537323; See PMID 9537365; uncharacterized protein 328544 4990533 An04g01310 Aspergillus niger uncharacterized protein XP_001401496.1 327297 D 5061 CDS An04g01320 4990534 complement(join(329551..330330,330403..330681,330758..330979)) VI 1 NT_166539.1 EC:1.14.99.-; Title: strong similarity to fatty acid desaturase from patent WO9846764-A1 - Homo sapiens; uncharacterized protein 330979 4990534 An04g01320 Aspergillus niger uncharacterized protein XP_001401497.1 329551 R 5061 CDS An04g01330 4990535 complement(join(331350..331406,331461..331547,331599..331760,331817..332080,332139..332689,332815..332949,333043..333082)) VI 1 NT_166539.1 Catalytic activity: L-methionylpeptide + H(2)O <=> L-methionine + peptide.; Cofactor: Cobalt.; Function: the human methionyl aminopeptidase P67EIF2 removes the amino-terminal methionine from nascent proteins.; Remark: alternate name for human methionyl aminopeptidase P67EIF2: p67 or translation initiation factor eIF-2-associated protein.; Title: strong similarity to methionyl aminopeptidase P67EIF2 - Homo sapiens; cytoplasm; See PMID 8858118; uncharacterized protein 333082 4990535 An04g01330 Aspergillus niger uncharacterized protein XP_059600479.1 331350 R 5061 CDS An04g01340 4990536 complement(join(334413..334455,334523..334627,334686..335944,336007..336155,336225..336260,336314..336340,336406..336431,336489..336539,336661..336686)) VI 1 NT_166539.1 Catalytic activity: ATP + L-aspartate + L-glutamine <=> AMP + diphosphate + L-asparagine + L-glutamate.; Remark: alternate name for S. cerevisiae Asn1: YPR145W.; Title: strong similarity to asparagine synthase Asn1 - Saccharomyces cerevisiae; See PMID 8951815; See PMID 348677; uncharacterized protein 336686 4990536 An04g01340 Aspergillus niger uncharacterized protein XP_001401499.1 334413 R 5061 CDS An04g01350 4990537 complement(join(337719..337972,338087..338110,338174..338447)) VI 1 NT_166539.1 Catalytic activity: ATP + ubiquitin + protein lysine <=> AMP + diphosphate + protein N-ubiquityllysine.; Function: S. pombe Hus5 catalyzes the covalent attachment of ubiquitin to other proteins. It is required for efficient recovery from DNA damage or S-phase arrest and normal mitosis.; Title: strong similarity to E2-type ubiquitin--protein ligase hus5p - Schizosaccharomyces pombe; See PMID 7768995; uncharacterized protein 338447 4990537 An04g01350 Aspergillus niger uncharacterized protein XP_059605246.1 337719 R 5061 CDS An04g01360 4990538 complement(join(339445..339543,339604..339696,339744..341008,341110..341302)) VI 1 NT_166539.1 Remark: expression of DRT111 Arabidopsis thaliana cDNA restored conjugal recombination proficiencies in ruvC and ruvC recG E. coli mutants to nearly wild-type level.; Title: similarity to DNA-damage repair protein precursor DRT111 - Arabidopsis thaliana; See PMID 8479917; uncharacterized protein 341302 4990538 An04g01360 Aspergillus niger uncharacterized protein XP_059605247.1 339445 R 5061 CDS An04g01370 4990539 join(341759..342292,342370..342406,342489..343360,343431..343467,343558..343625) VI 1 NT_166539.1 Similarity: the ORF encoded protein shows stongest similarity to the S. cerevisae Pcs60 (Fat2,YBR222C) protein from which is known to be localized at peroxisomal peripheral membrane and in the peroxisomal matrix, which could be a long chain acyl-CoA synthetase (Pubmed 8841414). But any specific Pcs60 activity remains unknown yet.; Title: strong similarity to malonyl CoA synthase matB - Rhizobium trifolii; See PMID 9826185; uncharacterized protein 343625 4990539 An04g01370 Aspergillus niger uncharacterized protein XP_001401502.3 341759 D 5061 CDS An04g01380 4990540 complement(join(343800..344074,344136..345559,345618..345669,345727..345881,345947..346181,346252..346417,346507..346548)) VI 1 NT_166539.1 Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: the similarities of the ORF encoded protein to MUC1 from yeast and the other proteins are mainly based on repetitive stretches in the sequence.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942; uncharacterized protein 346548 4990540 An04g01380 Aspergillus niger uncharacterized protein XP_001401503.1 343800 R 5061 CDS An04g01390 4990541 complement(join(347536..347585,347640..347998,348048..348252,348301..348312,348370..348529,348586..349266)) VI 1 NT_166539.1 Function: when the human ATA1 cDNA is expressed heterologously in mammalian cells, the cloned transporter mediates Na(+)-coupled transport of the system A-specific model substrate alpha-(methylamino)isobutyric acid.; Title: strong similarity to amino acid transporter ATA1 - Homo sapiens; See PMID 10891391; uncharacterized protein 349266 4990541 An04g01390 Aspergillus niger uncharacterized protein XP_059605248.1 347536 R 5061 CDS An04g01400 84590818 join(350205..350343,350624..350775,350812..351138,351189..351782) VI 1 NT_166539.1 Title: weak similarity to vacuolar protein Vac7 -Saccharomyces cerevisiae; See PMID 9372916; uncharacterized protein 351782 84590818 An04g01400 Aspergillus niger uncharacterized protein XP_059605249.1 350205 D 5061 CDS An04g01410 4990543 complement(join(352448..352717,352769..352964,353019..353175,353271..353325)) VI 1 NT_166539.1 Similarity: the ORF encoded protein shows strong similarity to the uncharacterized Siw14 (YNL032w) protein from S. cerevisiae. The siw14 null mutant fails to show cell cycle arrest upon nutrient starvation.; Title: similarity to protein fragment SEQ ID NO:6371 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 353325 4990543 An04g01410 Aspergillus niger uncharacterized protein XP_001401506.1 352448 R 5061 CDS An04g01420 4990544 complement(join(354184..354241,354419..354609,354665..355155,355212..355389,355465..355694,355846..355969)) VI 1 NT_166539.1 Remark: alternate name for E. coli TatD: MttC.; Remark: the Escherichia coli Tat system mediates Sec-independent export of protein precursors bearing twin arginine signal peptides. Genes known to be involved in this process include tatA, tatB, and tatC that form an operon with a fourth gene, tatD. TatD has no obligate involvement in protein export by the Tat system.; Title: strong similarity to protein with DNase activity tatD - Escherichia coli; See PMID 10747959; uncharacterized protein 355969 4990544 An04g01420 Aspergillus niger uncharacterized protein XP_059605250.1 354184 R 5061 CDS An04g01427 84590819 join(358968..359080,359298..359371,359481..359689) VI 1 NT_166539.1 hypothetical protein 359689 84590819 An04g01427 Aspergillus niger hypothetical protein XP_059605251.1 358968 D 5061 CDS An04g01430 4990546 join(359899..360120,360193..360281,360360..360804) VI 1 NT_166539.1 Title: weak similarity to hypothetical protein encoded by B11A5.120 - Neurospora crassa; uncharacterized protein 360804 4990546 An04g01430 Aspergillus niger uncharacterized protein XP_001401509.1 359899 D 5061 CDS An04g01440 4990547 363466..364908 VI 1 NT_166539.1 Function: the human Pepsin A shows particularly broad specificity, although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.; Remark: the human Pepsin A is the predominant endopeptidase in the gastric juice of vertebrates, formed from pepsinogen a by limited proteolysis.; Title: strong similarity to precursor of pepsin A3 -Homo sapiens; extracellular/secretion proteins; See PMID 3197840; uncharacterized protein 364908 4990547 An04g01440 Aspergillus niger uncharacterized protein XP_001401510.1 363466 D 5061 CDS An04g01450 4990548 complement(join(365206..366292,366340..366458,366493..366573)) VI 1 NT_166539.1 Catalytic activity: (S)-2-hydroxy-acid + O(2) <=> 2-oxo acid + H(2)O(2); Similarity: shows similarity o several different oxidoreductases.; Title: similarity to glycolate oxidase GOX - Mus musculus; See PMID 9891009; uncharacterized protein 366573 4990548 An04g01450 Aspergillus niger uncharacterized protein XP_059605252.1 365206 R 5061 CDS An04g01460 4990549 join(367360..367665,367726..367790,367843..368139,368194..368375,368430..368983) VI 1 NT_166539.1 Remark: protein belongs to a family of mitochondrial long chain acyl-CoA thioesterases.; Title: strong similarity to acyl-CoA thioesterase act48.1 - Mus musculus; localisation:mitochondrion; See PMID 10383425; uncharacterized protein 368983 4990549 An04g01460 Aspergillus niger uncharacterized protein XP_001401512.1 367360 D 5061 CDS An04g01470 4990550 join(369385..369501,369629..369916,370005..370087,370125..370235,370328..370347,370618..370826) VI 1 NT_166539.1 Title: weak similarity to hypothetical protein CAC37491.1 - Schizosaccharomyces pombe; uncharacterized protein 370826 4990550 An04g01470 Aspergillus niger uncharacterized protein XP_059605253.1 369385 D 5061 CDS An04g01480 4990551 complement(join(373417..373855,373919..374269,374527..374748,375052..375197)) VI 1 NT_166539.1 Catalytic activity: protein of S. cerevisiae converts protein tyrosine phosphate + H2O to protein tyrosine + orthophosphate.; Function: protein of S. cerevisiae is involved in the control network regulating meiosis and sporulation.; Title: strong similarity to protein tyrosine phosphatase Yvh1 - Saccharomyces cerevisiae; See PMID 10464190; uncharacterized protein 375197 4990551 An04g01480 Aspergillus niger uncharacterized protein XP_059605254.1 373417 R 5061 CDS An04g01490 84590820 join(377324..377382,377439..377534,377575..377629,377671..377760,377836..377941,378388..378482,378572..378889) VI 1 NT_166539.1 hypothetical protein 378889 84590820 An04g01490 Aspergillus niger hypothetical protein XP_059605255.1 377324 D 5061 CDS An04g01500 4990553 join(382682..384258,384313..384811) VI 1 NT_166539.1 Function: the ORF contains zinc-finger domain and therefore might be involved in transcriptional regulation.; Similarity: blast hits result from repetitive sequences.; Similarity: the ORF shows similarity to the A. niger protein An01g13790. The similarity between the two proteins, however, is restricted to a stretch of only about 100 amino acids.; Title: weak similarity to polypeptide SEQ ID NO:21489 from patent WO200171042-A2 - Drosophila melanogaster; uncharacterized protein 384811 4990553 An04g01500 Aspergillus niger uncharacterized protein XP_001401516.1 382682 D 5061 CDS An04g01510 84590821 join(385350..385371,385479..385555,385628..385729) VI 1 NT_166539.1 hypothetical protein 385729 84590821 An04g01510 Aspergillus niger hypothetical protein XP_059605256.1 385350 D 5061 CDS An04g01520 4990555 complement(join(386018..387409,387446..387578,387642..387814)) VI 1 NT_166539.1 Complex: protein of S. pombe is associated with nuclear pore complexes and mitotic spindle pole bodies.; Function: its role as an anchor in the nuclear envelope is essential for mitosis.; Title: similarity to nuclear envelope protein cut11p - Schizosaccharomyces pombe; nucleus; See PMID 9763447; uncharacterized protein 387814 4990555 An04g01520 Aspergillus niger uncharacterized protein XP_059605257.1 386018 R 5061 CDS An04g01530 4990556 join(388537..388833,388913..389437) VI 1 NT_166539.1 Function: it is required for delivery of VPS10 protein from the Golgi complex to the endosome.; Function: it may mediate the docking of Golgi-derived transport vesicles at the vacuole.; Function: it plays a role in sorting and targeting of vacuolar proteinases.; Function: protein of S. cerevisiae is involved in transport from the Golgi complex to the vacuole.; Title: strong similarity to transport vesicle docking protein Pep12 - Saccharomyces cerevisiae; endosome; See PMID 8730101; uncharacterized protein 389437 4990556 An04g01530 Aspergillus niger uncharacterized protein XP_001401519.1 388537 D 5061 CDS An04g01535 4990557 complement(389799..390668) VI 1 NT_166539.1 Catalytic activity: Holocytochrome c = Apocytochrome c + Heme.; Function: Cyt2 from S. cerevisiae is required for covalent attachment of heme to apocytochrome c1, a subunit of the mitochondrial respiratory chain.; Title: strong similarity to holocytochrome-c synthase Cyt2 - Saccharomyces cerevisiae; See PMID 8082171; See PMID 1499554; uncharacterized protein 390668 4990557 An04g01535 Aspergillus niger uncharacterized protein XP_001401520.1 389799 R 5061 CDS An04g01540 4990558 join(390980..391050,391117..392260) VI 1 NT_166539.1 Catalytic activity: converts ATP + (R)-5-Diphosphomevalonate = ADP + Orthophosphate + Isopentenyl diphosphate + CO2.; Remark: alternative gene names for S. cerevisiae are MVD1 and MPD.; Title: strong similarity to diphosphomevalonate decarboxylase Erg19 - Saccharomyces cerevisiae; See PMID 8626466; See PMID 1779710; uncharacterized protein 392260 4990558 An04g01540 Aspergillus niger uncharacterized protein XP_001401521.1 390980 D 5061 CDS An04g01550 4990559 complement(join(392619..393682,393757..394036,394096..394229,394281..394525,394575..394917,394975..395736,395789..395881,395932..397069)) VI 1 NT_166539.1 Remark: Disruption of the IKI3 gene in yeast is non-lethal and it has the killer-insensitive phenotype.; Title: strong similarity to killer toxin insensitive protein 3 Iki3 - Saccharomyces cerevisiae; See PMID 9145530; uncharacterized protein 397069 4990559 An04g01550 Aspergillus niger uncharacterized protein XP_059605258.1 392619 R 5061 CDS An04g01560 4990560 complement(join(397557..397582,397645..397677,397744..397921)) VI 1 NT_166539.1 Function: the cytochrome-c oxidase complex catalyzes the oxidation of four molecules of reduced cytochrome c in the intracristal (or intermembrane) space of mitochondria using one oxygen molecule and four protons from the mitochondrial matrix producing two molecules of water and lowering the concentration of protons in the mitochondrial matrix.; Pathway: oxidative phosphorylation; respiratory chain.; Remark: the role of chain VIIc is not clear.; Similarity: shows strong similarity to N. crassa cytochrome-c oxidase chain VIIc.; Title: strong similarity to subunit VIIc of cytochrome c oxidase - Bos primigenius taurus; localisation:mitochondrion; See PMID 213363; See PMID 1655579; See PMID 2554257; uncharacterized protein 397921 4990560 An04g01560 Aspergillus niger uncharacterized protein XP_001401523.1 397557 R 5061 CDS An04g01570 4990561 join(398298..399144,399197..400258,400311..400906,400964..401529,401616..401796) VI 1 NT_166539.1 Function: This enzyme seems to be a member of the DEAD box helicases that are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport,translation, RNA decay and organellar gene expression.; Function: helicase, the human protein has ATPase activitiy.; Title: strong similarity to helicase SKI2W - Homo sapiens; See PMID 7610041; uncharacterized protein 401796 4990561 An04g01570 Aspergillus niger uncharacterized protein XP_001401524.1 398298 D 5061 CDS An04g01580 4990562 404382..405173 VI 1 NT_166539.1 Remark: the cut8 gene product is required for normal progression of anaphase.; Remark: the temperature sensitivity cut8-563 mutation causes chromosome overcondensation and short spindle formation in the absence of sister chromatid separation.; Title: strong similarity to protein kinase cut8p -Schizosaccharomyces pombe; deleted EC_number 2.7.1.37; See PMID 8065367; See PMID 10582241; uncharacterized protein 405173 4990562 An04g01580 Aspergillus niger uncharacterized protein XP_001401525.3 404382 D 5061 CDS An04g01590 4990563 complement(406685..408016) VI 1 NT_166539.1 Remark: similarities only with serine rich regions.; Title: weak similarity to profilaggrin FLG - Homo sapiens; uncharacterized protein 408016 4990563 An04g01590 Aspergillus niger uncharacterized protein XP_059605259.1 406685 R 5061 CDS An04g01600 4990564 join(409127..409946,409999..410955,411006..411323,411376..411557,411711..412052) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein B1D1.80 - Neurospora crassa; uncharacterized protein 412052 4990564 An04g01600 Aspergillus niger uncharacterized protein XP_001401527.1 409127 D 5061 CDS An04g01610 4990565 complement(join(412575..412752,412825..413618)) VI 1 NT_166539.1 Catalytic activity: 2-acetolyctate + CO(2) = 2-pyruvate.; Pathway: first step in valine and isoleucine biosynthesis.; Remark: this enzyme also catalyzes formation of 2-aceto-2-hydroxybutanoate.; Title: strong similarity to acetolactate synthase regulatory chain Ilv6 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8972574; See PMID 10213630; uncharacterized protein 413618 4990565 An04g01610 Aspergillus niger uncharacterized protein XP_001401528.1 412575 R 5061 CDS An04g01620 4990566 join(414447..414645,414735..414814,414886..415047,415321..415342,415430..415482,415541..415705,415805..416013,416099..416630,416700..416723) VI 1 NT_166539.1 Remark: protein has glycine, glutamine and proline rich regions.; Title: similarity to transcription factor ZFM1 -Homo sapiens; See PMID 9212169; See PMID 9506990; uncharacterized protein 416723 4990566 An04g01620 Aspergillus niger uncharacterized protein XP_001401529.3 414447 D 5061 CDS An04g01630 4990567 complement(join(417265..418656,418706..418740,418808..418926,418991..419070)) VI 1 NT_166539.1 Function: A. nidulans recQ helicase is likely to play an important role in the maintenance of genomic integrity.; Title: strong similarity to DNA helicase recQ -Aspergillus nidulans; nucleus; See PMID 10377891; See PMID 11092746; uncharacterized protein 419070 4990567 An04g01630 Aspergillus niger uncharacterized protein XP_001401530.1 417265 R 5061 CDS An04g01640 4990568 complement(419534..422062) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein B23I11.240 - Neurospora crassa; uncharacterized protein 422062 4990568 An04g01640 Aspergillus niger uncharacterized protein XP_001401531.1 419534 R 5061 CDS An04g01650 4990569 join(422606..423036,423126..423483) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein B23I11.250 - Neurospora crassa; mitochondrial 37S ribosomal protein mS23 423483 4990569 An04g01650 Aspergillus niger mitochondrial 37S ribosomal protein mS23 XP_001401532.1 422606 D 5061 CDS An04g01660 4990570 join(424652..425085,425147..425258,425322..425671,425725..427800,428492..428513,428561..428581,428719..428729,428849..428981) VI 1 NT_166539.1 Catalytic activity: ATP = 3',5'-cyclic AMP + pyrophosphate.; Similarity: shows similarity to other fungal adenylate cyclases.; Title: similarity to adenylate cyclase uac1 -Ustilago maydis; See PMID 7995519; See PMID 9756717; uncharacterized protein 428981 4990570 An04g01660 Aspergillus niger uncharacterized protein XP_001401533.3 424652 D 5061 CDS An04g01665 84590822 join(430327..430533,430638..430799) VI 1 NT_166539.1 hypothetical protein 430799 84590822 An04g01665 Aspergillus niger hypothetical protein XP_059605260.1 430327 D 5061 CDS An04g01670 4990572 join(434484..435033,435073..435413,435480..436400) VI 1 NT_166539.1 Function: overexpression of SOK1 in S. cerevisiae restores growth to a strain (tpk1 tpk2 tpk3) lacking all A kinase activity.; Remark: S. cerevisiae cyclic AMP-dependent protein kinase (A kinase) activity is essential for growth and cell cycle progression.; Remark: classification according to MIPS funcat.; Title: similarity to suppressor of kinase protein Sok1 - Saccharomyces cerevisiae; nucleus; See PMID 8065298; uncharacterized protein 436400 4990572 An04g01670 Aspergillus niger uncharacterized protein XP_059605261.1 434484 D 5061 CDS An04g01680 4990573 join(437171..438264,438379..438397,438515..438568) VI 1 NT_166539.1 Title: similarity to hypothetical protein B23I11.190 - Neurospora crassa; uncharacterized protein 438568 4990573 An04g01680 Aspergillus niger uncharacterized protein XP_001401536.3 437171 D 5061 CDS An04g01690 4990574 complement(join(438941..439201,439260..439472,439533..440048)) VI 1 NT_166539.1 Remark: similarity only over alanine, threonine and serine rich regions.; Title: similarity to hypothetical precursor of glycoprotein X - equine herpesvirus 1; uncharacterized protein 440048 4990574 An04g01690 Aspergillus niger uncharacterized protein XP_001401537.1 438941 R 5061 CDS An04g01700 4990575 442932..443789 VI 1 NT_166539.1 Title: strong similarity to hypothetical protein SPAC694.03 - Schizosaccharomyces pombe; uncharacterized protein 443789 4990575 An04g01700 Aspergillus niger uncharacterized protein XP_001401538.1 442932 D 5061 CDS An04g01710 4990576 complement(join(444134..444459,444539..444608)) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein B23I11.140 - Neurospora crassa; uncharacterized protein 444608 4990576 An04g01710 Aspergillus niger uncharacterized protein XP_001401539.1 444134 R 5061 CDS An04g01720 4990577 join(445276..445543,445618..445881,445933..446468) VI 1 NT_166539.1 Function: DnaJ-domain is part of a chaperone system and involved in protein folding and transportation.; Function: contains a DNAJ domain and might therefore be associated with hsp70-like heat-shock systems.; Title: similarity to DnaJ protein SIS1 -Cryptococcus curvatus; See PMID 9559550; uncharacterized protein 446468 4990577 An04g01720 Aspergillus niger uncharacterized protein XP_001401540.1 445276 D 5061 CDS An04g01730 4990578 join(447199..447228,447320..448014,448077..448287,448343..448798,448859..450446,450498..450647,450703..450794) VI 1 NT_166539.1 Pathway: involved in N-terminal ubiquitin fusion degradation proteolytic pathway (UFD pathway).; Remark: yeast protein appears to influence the formation and topology of the multi-UB chain.; Similarity: N terminus might be too long or there might exist alternative splicing.; Title: strong similarity to ubiquitin fusion degradation protein Ufd2 - Saccharomyces cerevisiae; See PMID 7615550; See PMID 10089879; uncharacterized protein 450794 4990578 An04g01730 Aspergillus niger uncharacterized protein XP_001401541.1 447199 D 5061 CDS An04g01740 4990579 451418..452335 VI 1 NT_166539.1 Function: Udh1 from U. maydis complements the Arabidopsis steroid reductase mutant det2-1.; Remark: udh1 from U. maydis is induced during the parasitic interaction with its host plant maize.; Title: similarity to steroid 5alpha-reductase UDH1 -Ustilago maydis; See PMID 12068114; uncharacterized protein 452335 4990579 An04g01740 Aspergillus niger uncharacterized protein XP_001401542.3 451418 D 5061 CDS An04g01750 4990580 complement(join(453040..455133,455190..455409,455480..455490)) VI 1 NT_166539.1 Catalytic activity: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.; Title: strong similarity to 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase Met6 - Saccharomyces cerevisiae; See PMID 3542720; uncharacterized protein 455490 4990580 An04g01750 Aspergillus niger uncharacterized protein XP_001401543.1 453040 R 5061 CDS An04g01760 4990581 join(457194..457311,457365..458851,458922..459632) VI 1 NT_166539.1 Similarity: blast hits due to repetive sequences.; hypothetical protein 459632 4990581 An04g01760 Aspergillus niger hypothetical protein XP_001401544.1 457194 D 5061 CDS An04g01770 4990582 complement(join(460012..461599,461656..461773,461835..461928)) VI 1 NT_166539.1 Function: DMAP1 has intrinsic transcription repressive activity, and binds to the transcriptional co-repressor TSG101 in human.; Remark: DMAP1 is targeted to replication foci through interaction with the far N terminus of DNMT1 throughout S phase in human.; Remark: gaps cannot be closed and may result from sequencing errors that do not allow correct gene prediction.; Title: strong similarity to DNMT1 associated protein-1 DMAP1 - Homo sapiens [putative sequencing error]; See PMID 10888872; uncharacterized protein 461928 4990582 An04g01770 Aspergillus niger uncharacterized protein XP_001401545.1 460012 R 5061 CDS An04g01780 4990583 join(462240..462399,462471..462859,462930..463079) VI 1 NT_166539.1 Function: contains domain of emp24/gp25L/p24 family and might be involved in bringing cargo forward from the ER and binding to coat proteins by their cytoplasmic domains.; Title: strong similarity to hypothetical protein YAR002c-a - Saccharomyces cerevisiae; uncharacterized protein 463079 4990583 An04g01780 Aspergillus niger uncharacterized protein XP_001401546.1 462240 D 5061 CDS An04g01790 4990584 complement(join(464368..466256,466318..467308)) VI 1 NT_166539.1 Remark: the barA protein was demonstrated in vitro to undergo phosphorylation in the presence of ATP in E. coli.; Title: similarity to sensor-regulator protein barA -Escherichia coli; See PMID 10931332; uncharacterized protein 467308 4990584 An04g01790 Aspergillus niger uncharacterized protein XP_001401547.1 464368 R 5061 CDS An04g01800 4990585 complement(join(469155..469298,469378..469832,469889..469907,469973..469975)) VI 1 NT_166539.1 Localization: PUP3 of S. cerevisiae is cytoplasmic and nuclear.; Remark: PUP3 of S. cerevisiae is also known as SCS32 and has a systematic name of YER094C.; Title: strong similarity to proteasome 20S subunit Pup3 - Saccharomyces cerevisiae; See PMID 9207060; See PMID 9278475; See PMID 10500111; uncharacterized protein 469975 4990585 An04g01800 Aspergillus niger uncharacterized protein XP_001401548.1 469155 R 5061 CDS An04g01810 4990586 join(470418..470554,470612..472001) VI 1 NT_166539.1 Title: similarity to hypothetical protein AAH19177.1 - Mus musculus; uncharacterized protein 472001 4990586 An04g01810 Aspergillus niger uncharacterized protein XP_001401549.1 470418 D 5061 CDS An04g01820 4990587 complement(join(472690..472773,473193..473378,473803..473850)) VI 1 NT_166539.1 Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L36 L39 - Candida albicans; cytoplasm; See PMID 9364745; 60S ribosomal protein eL36 473850 4990587 An04g01820 Aspergillus niger 60S ribosomal protein eL36 XP_001401550.1 472690 R 5061 CDS An04g01830 4990588 complement(join(476622..477368,477418..477530,477581..478343,478395..478674,478729..479069,479175..479333,479423..479698,479799..479933)) VI 1 NT_166539.1 Function: the S. pombe homolog in S. cerevisiae is necessary for mitochondrial inheritance and organization of the actin cytoskeleton.; Title: similarity to hypothetical DEC1 protein homolog - Schizosaccharomyces pombe; uncharacterized protein 479933 4990588 An04g01830 Aspergillus niger uncharacterized protein XP_059606867.1 476622 R 5061 CDS An04g01840 4990589 join(484352..484722,484777..485122,485175..485618) VI 1 NT_166539.1 Similarity: the ORF shows also weak similarity to proteins containing PTS domain.; Title: strong similarity to hypothetical protein EAA63252.1 - Aspergillus nidulans; uncharacterized protein 485618 4990589 An04g01840 Aspergillus niger uncharacterized protein XP_001401552.1 484352 D 5061 CDS An04g01850 4990590 join(487266..487358,487419..487538,487598..487690,487758..488873) VI 1 NT_166539.1 Similarity: shows similarity to mainly the zf-C3H4C zinc finger domains of several proteins.; Title: similarity to hypothetical zf-C3H4C zinc finger protein SPCC548.05c - Schizosaccharomyces pombe; uncharacterized protein 488873 4990590 An04g01850 Aspergillus niger uncharacterized protein XP_059606868.1 487266 D 5061 CDS An04g01860 4990591 complement(join(490380..491879,491956..492324)) VI 1 NT_166539.1 Function: so far, only one human U3 snoRNA-associated protein, fibrillarin, has been characterized.; Function: the eukaryotic nucleolus contains a large number of small RNA molecules (snoRNAs) which, in the form of small nucleolar ribonucleoprotein complexes (snoRNPs),are involved in the processing and modification of pre-rRNA.; Similarity: shows stronger similarity to fungal snoRNP associated proteins that are not yet described.; Title: similarity to U3 snoRNP associated 55 kDa protein U3-55k - Homo sapiens; nucleus; See PMID 9418896; uncharacterized protein 492324 4990591 An04g01860 Aspergillus niger uncharacterized protein XP_001401554.1 490380 R 5061 CDS An04g01870 4990592 join(<492734..492893,492969..493218,493282..493405,493468..493545) VI 1 NT_166539.1 Protein sequence is in conflict with the conceptual translation; Localization: yeast proteasomes are mainly localized in the nuclear envelope-ER network.; Remark: putative sequencing error at position 13492 might have destroyed the start codon.; Title: strong similarity to proteasome 20S subunit Pre1 - Saccharomyces cerevisiae [putative sequencing error]; putative sequencing error; uncharacterized protein 493545 4990592 An04g01870 Aspergillus niger uncharacterized protein XP_001401555.1 492734 D 5061 CDS An04g01880 4990593 join(493923..494604,494659..495510,495628..495827) VI 1 NT_166539.1 Catalytic activity: UBP4 of M. musculus catalyses ubiquitin C-terminal thiolester + H(2)O <=> ubiquitin + a thiol.; Function: UBP4 of M. musculus is a ubiquitin thiolesterase, that recognizes and hydrolyze the peptide bond at the C-terminal glycine of ubiquitin, and is therefore involved in the processing of poly-ubiquitin precursors as well as that of ubiquinated proteins.; Phenotype: overexpression of UBP4 of M. musculus leads to oncogenic transformation of NIH 3T3 cells.; Remark: an alternate name for UBP4 of M. musculus is UNP.; Title: similarity to ubiquitin thiolesterase 4 UBP4 - Mus musculus; See PMID 9602026; uncharacterized protein 495827 4990593 An04g01880 Aspergillus niger uncharacterized protein XP_059606869.1 493923 D 5061 CDS An04g01890 4990594 complement(join(496201..498055,498105..498340,498411..498776,499054..499089)) VI 1 NT_166539.1 Title: similarity to hypothetical protein CAC28698.1 - Neurospora crassa; uncharacterized protein 499089 4990594 An04g01890 Aspergillus niger uncharacterized protein XP_001401557.1 496201 R 5061 CDS An04g01900 4990595 join(499461..499634,499689..499716,499788..500074,500162..501377,501423..502516) VI 1 NT_166539.1 Function: beta-transducin (G-beta) is one of the three subunits (alpha, beta, and gamma) of the guanine nucleotide-binding proteins (G proteins) which act as intermediaries in the transduction of signals generated by transmembrane receptors.; Function: the alpha subunit binds to and hydrolyzes GTP; the functions of the beta and gamma subunits are less clear but they seem to be required for the replacement of GDP by GTP as well as for membrane anchoring and receptor recognition.; Similarity: shows higher similarity to undescribed WD (G-beta)-repeat proteins of several organisms.; Title: similarity to Dom34p-interacting protein Dip2 - Saccharomyces cerevisiae; See PMID 9384580; uncharacterized protein 502516 4990595 An04g01900 Aspergillus niger uncharacterized protein XP_059606870.1 499461 D 5061 CDS An04g01910 4990596 complement(502914..504560) VI 1 NT_166539.1 Similarity: some blast hits result from repetitive sequences.; Title: weak similarity to protein involved in spliceosome maturation Spp2 - Saccharomyces cerevisiae; uncharacterized protein 504560 4990596 An04g01910 Aspergillus niger uncharacterized protein XP_001401559.1 502914 R 5061 CDS An04g01920 4990597 complement(join(505270..506418,506474..506631,506691..509629,509780..509923,510006..510049)) VI 1 NT_166539.1 Title: similarity to hypothetical protein SPCC1795.08c - Schizosaccharomyces pombe; uncharacterized protein 510049 4990597 An04g01920 Aspergillus niger uncharacterized protein XP_001401560.1 505270 R 5061 CDS An04g01930 4990598 join(510779..511717,511772..512371) VI 1 NT_166539.1 Remark: introns can not be integrated, putatively because of sequencing errors.; Title: similarity to protein involved in cell growth and replication of M1 dsRNA Mak11 - Saccharomyces cerevisiae; uncharacterized protein 512371 4990598 An04g01930 Aspergillus niger uncharacterized protein XP_059606871.1 510779 D 5061 CDS An04g01940 4990599 join(512966..513489,513555..514541,514621..514651) VI 1 NT_166539.1 Similarity: Elongation factor Tu family is overall conserved.; Title: strong similarity to translation initiation factor eIF2 gamma chain Gcd11 - Saccharomyces cerevisiae; cytoplasm; See PMID 7774582; See PMID 9079882; uncharacterized protein 514651 4990599 An04g01940 Aspergillus niger uncharacterized protein XP_001401562.1 512966 D 5061 CDS An04g01950 4990600 join(515390..515404,515510..515692,515757..516503,516586..516778,516843..517075) VI 1 NT_166539.1 Function: involved in first step of N-terminal processing of the a-factor precursor.; Function: performs the proteolytic removal of the last three amino acids after prenylation of the a-factor precursor.; Title: strong similarity to zinc-metalloprotease Ste24 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 9015299; See PMID 9700155; uncharacterized protein 517075 4990600 An04g01950 Aspergillus niger uncharacterized protein XP_001401563.1 515390 D 5061 CDS An04g01960 4990601 complement(517401..517916) VI 1 NT_166539.1 Title: weak similarity to hypothetical protein Y1032 - Yersinia pestis plasmid pMT1; uncharacterized protein 517916 4990601 An04g01960 Aspergillus niger uncharacterized protein XP_001401564.1 517401 R 5061 CDS An04g01970 4990602 join(518323..518387,518559..518919) VI 1 NT_166539.1 Similarity: shows similarity to several undescribed fungal ribosomal protein L34.; Title: weak similarity to ribosomal protein of the large subunit L34 - Bacillus stearothermophilus; mitochondrial 54S ribosomal protein bL34m 518919 4990602 An04g01970 Aspergillus niger mitochondrial 54S ribosomal protein bL34m XP_059606872.1 518323 D 5061 CDS An04g01980 4990603 complement(join(519834..520031,520094..522165,522215..523106)) VI 1 NT_166539.1 Function: hMP1 is a novel member of the metalloendoprotease superfamily with ubiquitous distribution that could play a broad role in general cellular regulation.; Title: similarity to metalloprotease 1 MP1 - Homo sapiens; uncharacterized protein 523106 4990603 An04g01980 Aspergillus niger uncharacterized protein XP_001401566.1 519834 R 5061 CDS An04g01990 4990604 join(524137..524298,524378..524873,524932..525955,526004..526823) VI 1 NT_166539.1 Function: human protein is centromere binding protein at prophase, metaphase, and early anaphase.; Function: it also binds kinetochore microtubules at metaphasehuman protein is involved in meiosis and mitosis.; Similarity: similarity is restricted to C-terminus.; Title: similarity to protein ZW10 homolog HZW10 -Homo sapiens; uncharacterized protein 526823 4990604 An04g01990 Aspergillus niger uncharacterized protein XP_059606873.1 524137 D 5061 CDS An04g02000 4990605 join(527064..527199,527281..528617) VI 1 NT_166539.1 Title: strong similarity to hypothetical microtubule-interacting protein Ytm1 - Saccharomyces cerevisiae; uncharacterized protein 528617 4990605 An04g02000 Aspergillus niger uncharacterized protein XP_001401568.1 527064 D 5061 CDS An04g02010 4990606 complement(join(528945..528989,529112..529378,529540..529542)) VI 1 NT_166539.1 Title: similarity to ribosomal protein of the small subunit S13 rpsM - Bacillus subtilis; localisation:mitochondrion; mitochondrial 37S ribosomal protein uS13m 529542 4990606 An04g02010 Aspergillus niger mitochondrial 37S ribosomal protein uS13m XP_059606874.1 528945 R 5061 CDS An04g02020 4990607 join(529939..530046,530130..530207,530278..530294,530359..530462,530534..530678,530735..530898,530986..531185) VI 1 NT_166539.1 Function: cyclophilins are an evolutionarily conserved family of proteins which serve as the intracellular receptors for the immunosuppressive drug cyclosporin A.; Function: cypB mRNA levels were significantly elevated under severe heat shock conditions, indicating a possible role for the A. nidulans cyclophilin B protein during growth in high stress environments.; Similarity: shows very high similarity to sequence of patent WO0018934.; Title: strong similarity to cyclophilin cypB -Aspergillus nidulans; endoplasmatic reticulum; See PMID 10413615; uncharacterized protein 531185 4990607 An04g02020 Aspergillus niger uncharacterized protein XP_059606875.1 529939 D 5061 CDS An04g02030 4990608 join(533499..533701,533773..535606) VI 1 NT_166539.1 Function: may play a role in mRNA splicing and/or in initiation of translation.; Localization: cytoplasmic and nuclear.; Title: strong similarity to ATP-dependent RNA helicase Ded1 - Saccharomyces cerevisiae; See PMID 9045610; uncharacterized protein 535606 4990608 An04g02030 Aspergillus niger uncharacterized protein XP_001401571.1 533499 D 5061 CDS An04g02040 4990609 join(537573..537996,538071..538610,538669..538722,538778..538825,538888..540272) VI 1 NT_166539.1 Title: similarity to hypothetical protein 15E6.120 -Neurospora crassa; uncharacterized protein 540272 4990609 An04g02040 Aspergillus niger uncharacterized protein XP_059606876.1 537573 D 5061 CDS An04g02050 4990610 join(542516..543199,543264..543626) VI 1 NT_166539.1 Title: similarity to hypoxia-induced protein #21 from patent WO200246465-A2 - Homo sapiens; uncharacterized protein 543626 4990610 An04g02050 Aspergillus niger uncharacterized protein XP_001401573.1 542516 D 5061 CDS An04g02060 4990611 join(544560..544584,544698..544743,544822..545049,545116..546601,546655..546810) VI 1 NT_166539.1 Catalytic activity: the first enzymatic activity catalyzing the second last step, the formylation of AICAR with 10-formyl-tetrahydrofolate to yield FAICAR and tetrahydrofolate, is a 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase.; Catalytic activity: the second enzymatic activity is that of an inosine monophosphate cyclohydrolase, cyclizing FAICAR (5-formylaminoimidazole-4-carboxamide ribonucleotide) to IMP.; Function: S. cerevisiae Ade17p belongs to a family of bifunctional enzymes catalysing the last two steps in de novo purine biosynthesis.; Remark: putative sequencing error might have lead to destruction of start codon at pos. 65661 might be a G.; Title: strong similarity to 5-aminoimidazole-4-carboxamide ribotide transformylase Ade17 - Saccharomyces cerevisiae [putative sequencing error]; See PMID 9143321; uncharacterized protein 546810 4990611 An04g02060 Aspergillus niger uncharacterized protein XP_059606877.1 544560 D 5061 CDS An04g02070 4990612 join(549135..549173,549248..549404,549498..549856,549925..554148,554210..554566) VI 1 NT_166539.1 Complex: clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat. in the presence of light chains, hub assembly is influenced by both the ph and the concentration of calcium.; Domain: the c-terminal third of the heavy chains forms the hub of the triskelion. this region contains the trimerization domain and the light-chain binding domain involved in the assembly of the clathrin lattice.; Function: clathrin is the major protein of the polyhedral coat of coated pits & vesicles. two different adaptor protein complexes link the clathrin lattice either to the plasma membrane or trans golgi network.; Localization: cytoplasmic face of coated pits and vesicles.; Similarity: belongs to the clathrin heavy chain family.; Title: strong similarity to clathrin heavy chain -Bos taurus; cytoplasm; uncharacterized protein 554566 4990612 An04g02070 Aspergillus niger uncharacterized protein XP_059606878.1 549135 D 5061 CDS An04g02080 84590823 join(556161..556302,556333..556436,556554..556662,556762..556816,556917..557538) VI 1 NT_166539.1 Remark: the genomic sequence of the predicted A. niger protein has been annotated as 5'UTR of the A. niger pyc gene in EMBL, however no reference justifying this annotation is available.; Title: questionable ORF; uncharacterized protein 557538 84590823 An04g02080 Aspergillus niger uncharacterized protein XP_059606879.1 556161 D 5061 CDS An04g02090 4990614 join(557605..561075,561136..561243) VI 1 NT_166539.1 Catalytic activity: pyruvate carboxylases convert ATP + pyruvate + HCO(3)(-) to ADP + phosphate + oxaloacetate.; Function: A. niger pyc is involved in the biosynthesis and degradation of citric acid.; Gene-ID: pyc; Localization: in five strains of Aspergillus niger,pyruvate carboxylase activity was detected both in the mitochondrial fraction and in the cytosol.; Localization: under conditions of growth and of citric acid production A. niger pyc was found predominantly or exclusively in the cytosol.; Remark: the A. niger ESTs an_2634, EMBLEST|BE759731,AN01B01, EMBLEST|ANI239747 and an_0874, EMBLEST|BE760887 cover the 3'end of the ORF and the 3'UTR until base 8796.; See PMID 2383004; See PMID 1777859; pyruvate carboxylase pyc-Aspergillus niger 561243 pyc 4990614 pyc Aspergillus niger pyruvate carboxylase pyc-Aspergillus niger XP_001401577.1 557605 D 5061 CDS An04g02100 4990615 complement(join(561606..562597,562673..562951,563011..563034,563090..563429)) VI 1 NT_166539.1 Function: B. subtilis p-Nitrobenzyl carboxy-esterase pnbA hydrolyses several beta-lactam antibiotic p-Nitrobenzyl esters to the corresponding free acid and p-Nitrobenzyl alcohol.; Remark: p-Nitrobenzyl esters serve as protecting groups on intermediates in the manufacture of clinically important oral beta-lactam antibiotics; de-esterification of the intermediates is required for synthesis of the final product.; Remark: the genomic sequence of the predicted A. niger protein has been annotated as 3'UTR of the A. niger pyc gene in EMBL, however neither ESTs nor any reference justifying this annotation are available.; Title: similarity to p-nitrobenzyl esterase pnbA -Bacillus subtilis; uncharacterized protein 563429 4990615 An04g02100 Aspergillus niger uncharacterized protein XP_001401578.1 561606 R 5061 CDS An04g02110 4990616 join(565013..565174,565286..565531) VI 1 NT_166539.1 Function: N. crassa con-8 is expressed early during conidial differentiation, its function is unknown.; Regulation: N. crassa con-8 is photoregulated.; Remark: N. crassa con-8 is unusual in that it is transcribed as two mRNA species, 1. 0 and 1. 25 kb in length.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with several A. niger ESTs (an_2280, 2959, 3447, 2227, 1543, 0899 and 1115).; Title: similarity to con-8 - Neurospora crassa; See PMID 7604041; See PMID 521382; uncharacterized protein 565531 4990616 An04g02110 Aspergillus niger uncharacterized protein XP_003188656.1 565013 D 5061 CDS An04g02120 4990617 complement(join(566514..566640,566748..566997,567117..567270)) VI 1 NT_166539.1 Function: S. cerevisiae RPL16 binds to 5S rRNA.; Localization: immunoelectron microscopy mapped RPL16 of S. cerevisiae near the top surface of the central protuberance of the large subunit (60S) of the ribosome,where 60S potentially contacts the 40 S subunit.; Remark: A. niger ESTs an_3183 and 2849 are in accordance with the exon/intron structure of the predicted A. niger protein.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L16 - Saccharomyces cerevisiae; cytoplasm; See PMID 7510288; 60S ribosomal protein uL5 567270 4990617 An04g02120 Aspergillus niger 60S ribosomal protein uL5 XP_001401580.3 566514 R 5061 CDS An04g02130 4990618 join(567731..567757,567849..567857,567914..567985,568060..568486,568543..568587,568643..568725) VI 1 NT_166539.1 Complex: U-1 and U-2 snRNPs contain 11 and 12 protein subunits respectively.; Function: human SmB is present in both U-1 and U-2 snRNPs, which are involved in splicing of nuclear pre-mRNAs.; Function: the 5' splice site (5'SS) and the branch site, which represent the two substrates for the first step of splicing, are first recognized by U1 and U2 snRNPs,respectively.; Title: similarity to U1 and U2 snRNPs component SmB - Homo sapiens; nucleus; See PMID 8371979; See PMID 10397335; See PMID 10490618; See PMID 1825643; uncharacterized protein 568725 4990618 An04g02130 Aspergillus niger uncharacterized protein XP_001401581.1 567731 D 5061 CDS An04g02140 4990619 join(569306..569378,569591..569663,569828..570134) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein YGL080w - Saccharomyces cerevisiae; uncharacterized protein 570134 4990619 An04g02140 Aspergillus niger uncharacterized protein XP_059606880.1 569306 D 5061 CDS An04g02150 4990620 complement(join(570816..570980,571044..573131)) VI 1 NT_166539.1 Function: glutamine transport by rat SN1 involves H+ exchange as well as Na+ cotransport and, under physiological conditions, mediates glutamine efflux as well as uptake.; Function: rat SN1 is an amino acid transporter mediating glutamine transport with a physiological role in nitrogen metabolism and synaptic transmission.; Title: similarity to amino acid system N transporter SN1 - Rattus norvegicus; plasma membrane; See PMID 10619430; uncharacterized protein 573131 4990620 An04g02150 Aspergillus niger uncharacterized protein XP_001401583.1 570816 R 5061 CDS An04g02160 4990621 join(573809..574307,574365..574956,575006..575171,575223..577703) VI 1 NT_166539.1 Complex: coimmunoprecipitation suggest a direct interaction of human CIP1 with NKCC.; Function: human CIP1 may be part of a novel family of proteins that modifies the activity or kinetics of CCCs through heterodimer formation.; Function: human CIP1 specifically inhibits human NKCC1-mediated (86)Rb(+) flux if expressed in the oocyte.; Remark: an alternative name for human CIP1 is hCCC6,while CIP1 has also been used as name for the human cyclin interacting protein 1.; Similarity: human CIP1 belongs to the cation-Cl(-) cotransporter (CCC) family.; Title: similarity to cation-Cl-cotransporter-interacting protein CIP1 - Homo sapiens; See PMID 10871601; uncharacterized protein 577703 4990621 An04g02160 Aspergillus niger uncharacterized protein XP_059606881.1 573809 D 5061 CDS An04g02170 4990622 complement(join(578222..578501,578557..578771,578836..578862,579051..579242,579289..579357)) VI 1 NT_166539.1 Title: strong similarity to hypothetical 3-hydroxyacyl-CoA-dehydrogenase hcd - Gibberella zeae; uncharacterized protein 579357 4990622 An04g02170 Aspergillus niger uncharacterized protein XP_059606882.1 578222 R 5061 CDS An04g02180 84590824 join(580217..580396,581244..581318,581396..581551,581591..581738,581811..>582058) VI 1 NT_166539.1 hypothetical protein 582058 84590824 An04g02180 Aspergillus niger hypothetical protein XP_059606883.1 580217 D 5061 CDS An04g02190 4990624 582479..583825 VI 1 NT_166539.1 Catalytic activity: S. cerevisiae ERG12 catalyzes the reversible phosphorylation of (R)-mevalonic acid utilizing ATP, this enzyme can also utilize GTP, CTP, and UTP.; Function: S. cerevisiae ERG12 is a mevalonate kinase involved in isoprenoid biosynthesis, specifically in ergosterol biosynthesis.; Function: S. cerevisiae ERG12 is not a rate-limiting enzyme; however its sensitivity to FFP could be a key regulatory mechanism in the sterol pathway of yeast.; Function: mutations in S. cerevisiae erg12/rar1 confer temperature-sensitive growth and increase the mitotic stability of plasmids whose replication is dependent on weak ARS elements.; Remark: alternativ names for S. cerevisiae ERG12 are RAR1 and YMR208W.; Title: strong similarity to mevalonate kinase Erg12 - Saccharomyces cerevisiae; cytoplasm; See PMID 2161381; See PMID 3323847; See PMID 1645230; uncharacterized protein 583825 4990624 An04g02190 Aspergillus niger uncharacterized protein XP_001401587.3 582479 D 5061 CDS An04g02200 4990625 complement(join(584464..586474,586594..586622)) VI 1 NT_166539.1 Title: similarity to hypothetical protein encoded by An16g00980 - Aspergillus niger; uncharacterized protein 586622 4990625 An04g02200 Aspergillus niger uncharacterized protein XP_059606884.1 584464 R 5061 CDS An04g02210 4990626 join(587505..587734,587800..587904,587962..588655) VI 1 NT_166539.1 Complex: C. albicans RAM2 heterodimerises with CDC43, which contains zinc- and substrate-binding residues.; Function: C. albicans RAM2 is the alpha subunit of protein geranylgeranyltransferase I (GGTase I) a heterodimeric zinc metalloenzyme which catalyse geranylgeranylation of a cysteine residue in proteins containing a C-terminal CaaL motif (C, Cys; a, aliphatic amino acid; L, Leu).; Function: C. albicans mutations in cdc43, lack detectable GGTase I activity, are viable but morphologically abnormal and loclisation of two substrates,Rho1p and Cdc42p, is shifted from the membranous fraction to the cytosolic fraction.; Title: strong similarity to protein geranylgeranyltransferase type I alpha subunit RAM2 -Candida albicans; See PMID 10376828; See PMID 10633104; uncharacterized protein 588655 4990626 An04g02210 Aspergillus niger uncharacterized protein XP_001401589.1 587505 D 5061 CDS An04g02220 4990627 complement(588903..590237) VI 1 NT_166539.1 Catalytic activity: L-serine dehydratases convert L-serine + H(2)O to pyruvate + NH(3) + H(2)O.; Function: S. cerevisiae CHA1 is the catabolic L-serine (L-threonine) dehydratase allowing growth on media with L-serine or L-threonine as sole nitrogen source.; Regulation: S. cerevisiae Cha4p is a positive regulator of CHA1 transcription, binding to the CHA1 5'UTR.; Regulation: S. cerevisiae NHP6A and NHP6B proteins are chromatin architectural factors, required for full induction of the CHA1 gene.; Regulation: S. cerevisiae chromatin-remodeling complex, RSC (remodels the structure of chromatin), is essential for maintaining a repressive chromatin structure at the CHA1 promoter.; Regulation: in S. cerevisiae expression of the CHA1 gene is transcriptionally induced by serine and threonine and inhibited by the presence of other good nitrogen sources.; Remark: A. niger ESTs AN05D04 and Nig095 are in accordance with the predicted Exon-Intron structure of this ORF.; Title: strong similarity to L-serine dehydratase Cha1 - Saccharomyces cerevisiae; See PMID 8246977; See PMID 1628804; See PMID 10329629; See PMID 11118215; uncharacterized protein 590237 4990627 An04g02220 Aspergillus niger uncharacterized protein XP_059606885.1 588903 R 5061 CDS An04g02230 4990628 complement(join(591027..591299,591372..591849,591908..592269,592322..592453,592510..592596,592660..592731,592781..592899,592964..593168)) VI 1 NT_166539.1 Catalytic activity: MetRS convert ATP + L-methionine + tRNA(Met) to AMP + diphosphate + L-methionyl-tRNA(Met); Remark: C. albicans mitochondrial MetRS is distinct from the cytoplasmic MetRS.; Title: strong similarity to mitochondrial methionine--tRNA ligase MetRS - Candida albicans; localisation:mitochondrion; See PMID 9714830; uncharacterized protein 593168 4990628 An04g02230 Aspergillus niger uncharacterized protein XP_001401591.1 591027 R 5061 CDS An04g02240 4990629 join(593488..593533,593593..594035) VI 1 NT_166539.1 Complex: human NXT1 binds to RNA binding mRNA-export factor TAP (also called NXF1), RNA binding and export inhibiting NXF2 and non RNA binding cytoplasmic NXF3.; Function: human NXT1 binds RanGTP and facilitates nuclear export of different classes of RNA and proteins.; Function: human NXT1 is involved in CRM1 (NES-containing-substrate receptor) dependent protein export and CRM1-independent RNA export.; Function: in nuclear transport each class of macromolecule is thought to have a distinct receptor that mediates the transport reaction; assembly and disassembly reactions of receptor-substrate complexes are coordinated by Ran, whose activity is influenced by NXT1.; Localization: NXT1 colocalizes with the nuclear pore complex (NPC) in mammalian cells and shuttles between the nucleus and the cytoplasm.; Remark: an alternativ name for human NXT1 is p15.; Title: similarity to RanGTP-binding protein NXT1 -Homo sapiens; See PMID 10567585; See PMID 10848583; See PMID 11073998; uncharacterized protein 594035 4990629 An04g02240 Aspergillus niger uncharacterized protein XP_001401592.1 593488 D 5061 CDS An04g02250 4990630 complement(join(594267..594362,594442..594488,594542..594625,594681..594693,594752..594787)) VI 1 NT_166539.1 Title: questionable ORF; uncharacterized protein 594787 4990630 An04g02250 Aspergillus niger uncharacterized protein XP_001401593.1 594267 R 5061 CDS An04g02260 4990631 join(595202..595265,595454..595582,595758..595807) VI 1 NT_166539.1 Remark: the exon/intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_2427 and 1054.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L38 - Rattus norvegicus; cytoplasm; 60S ribosomal protein eL38 595807 4990631 An04g02260 Aspergillus niger 60S ribosomal protein eL38 XP_001401594.1 595202 D 5061 CDS An04g02270 4990632 complement(join(596488..596527,596604..597211,597297..597376,597440..597461)) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein SPAC577.03c - Schizosaccharomyces pombe; uncharacterized protein 597461 4990632 An04g02270 Aspergillus niger uncharacterized protein XP_001401595.3 596488 R 5061 CDS An04g02280 4990633 complement(join(597771..597919,597971..598072,598132..599080,599136..599267,599371..599554,599635..599669)) VI 1 NT_166539.1 Complex: S. cerevisiae HYS2, CDC2 and POL32 heterotrimerise to form DNA-Pol III.; Function: S. cerevisiae DNA polymerase III plays an important role in DNA repair after irradiation,particularly in the error-prone and recombinational pathways.; Function: S. cerevisiae HYS2 is the 55kDa subunit of DNA dependent DNA-polymerase (DNA polymerase III (delta)) involved in DNA replication, base-excision repair, mismatch repair and post-replication repair.; Remark: alternative names for S. cerevisiae HYS2 are HUS2, POL31, SDP5 and YJR006W.; Title: strong similarity to subunit of DNA polymerase III (delta) Hys2 - Saccharomyces cerevisiae; nucleus; See PMID 7567461; See PMID 9258670; See PMID 9421503; See PMID 9677406; uncharacterized protein 599669 4990633 An04g02280 Aspergillus niger uncharacterized protein XP_059606886.1 597771 R 5061 CDS An04g02290 84590825 complement(join(600593..600883,600925..600991,601091..601206)) VI 1 NT_166539.1 hypothetical protein 601206 84590825 An04g02290 Aspergillus niger hypothetical protein XP_059606887.1 600593 R 5061 CDS An04g02300 4990635 602173..603213 VI 1 NT_166539.1 Catalytic activity: NADH specific Enoyl-[acyl-carrier protein] reductases convert acyl-[acyl-carrier protein] + NAD(+) to trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.; Complex: S. pneumoniae fabK contains a FAD-binding domain and is NADH specific.; Function: S. pneumoniae fabK is involved in fatty-acid biosynthesis and catalyses the reduction of enoyl-acyl-carrier-protein (ACP) during each cycle of fatty-acid elongation.; Remark: a splice site was detected upstream of the START codon.; Title: similarity to trans-2-enoyl-ACP reductase II fabK - Streptococcus pneumoniae; See PMID 10910344; uncharacterized protein 603213 4990635 An04g02300 Aspergillus niger uncharacterized protein XP_001401598.1 602173 D 5061 CDS An04g02310 4990636 complement(join(604065..604554,604611..604759,604837..605111,605183..605306)) VI 1 NT_166539.1 Function: chicken MDP77 promotes the neurite-outgrowth from the cultured chick neurons of the spinal cord in a dose-dependent manner.; Localization: transfected COS-7 cells secrete chicken MDP77 into the culture medium.; Title: similarity to neurite-outgrowth-promoting protein MDP77 - Gallus gallus; extracellular/secretion proteins; See PMID 10708594; uncharacterized protein 605306 4990636 An04g02310 Aspergillus niger uncharacterized protein XP_059606888.1 604065 R 5061 CDS An04g02320 84590826 join(606207..606580,606654..609465) VI 1 NT_166539.1 Similarity: human MP1 is a metalloendoproteases of the pitrilysin family.; Title: strong similarity to metalloprotease 1 MP1 -Homo sapiens; See PMID 10360838; uncharacterized protein 609465 84590826 An04g02320 Aspergillus niger uncharacterized protein XP_059606889.1 606207 D 5061 CDS An04g02330 4990637 join(610365..610416,610666..610975,611037..611785,611846..612060,612118..612181,612247..612605) VI 1 NT_166539.1 hypothetical protein 612605 4990637 An04g02330 Aspergillus niger hypothetical protein XP_059606890.1 610365 D 5061 CDS An04g02340 4990639 complement(join(612905..613231,613303..614022)) VI 1 NT_166539.1 Title: weak similarity to kinesin light chain -Strongylocentrotus purpuratus; uncharacterized protein 614022 4990639 An04g02340 Aspergillus niger uncharacterized protein XP_001401602.3 612905 R 5061 CDS An04g02350 84590827 join(614387..614526,614614..614688,614814..615298,615346..615948,616027..616114,616207..616297) VI 1 NT_166539.1 Remark: similarity to human FLEXHT-35 protein sequence SEQ ID NO:35 patent WO200070047-A2.; Title: similarity to FLEXHT-35 protein sequence SEQ ID NO:35 from patent WO200070047-A2 - Homo sapiens; uncharacterized protein 616297 84590827 An04g02350 Aspergillus niger uncharacterized protein XP_059606891.1 614387 D 5061 CDS An04g02360 4990641 complement(join(616363..616413,616468..617646)) VI 1 NT_166539.1 Function: this protein removes the n-acetyl group from bialaphos as one of the final steps of the bialaphos biosynthetic pathway.; Pathway: bialaphos biosynthesis.; Remark: the observation that Bah was similar to a rat and to a bacterial (Acinetobacter calcoaceticus) lipase probably reflects the fact that the ester bonds of triglycerides and the amide bond linking acetate to phosphinothricin are similar and hydrolysis is catalyzed by structurally related enzymes.; Remark: the predicted ORF is approximately 80 amino acids to long.; Similarity: belongs to the 'gdxg' family of lipolytic enzymes.; Similarity: belongs to the acetyl esterase family.; Title: similarity to bialaphos acetylhydrolase Bah -Streptomyces hygroscopicus; See PMID 2066341; uncharacterized protein 617646 4990641 An04g02360 Aspergillus niger uncharacterized protein XP_001401604.3 616363 R 5061 CDS An04g02370 4990642 complement(join(617937..618887,618944..619357)) VI 1 NT_166539.1 hypothetical protein 619357 4990642 An04g02370 Aspergillus niger hypothetical protein XP_059606892.1 617937 R 5061 CDS An04g02380 4990643 join(619805..619879,619944..620043,620103..620386,620446..620645,620679..620706) VI 1 NT_166539.1 Catalytic activity: RX + glutathione = HX + R-S-glutathione.; Function: might confer protection against genotoxic and cytotoxic electrophiles in the mitochondrial compartment. Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.; Localization: the rat GTK1 is localized in the mitochondial matrix.; Similarity: belongs to the gst superfamily, kappa family.; Title: similarity to subunit 13 of glutathione S-transferase GTK1 - Rattus norvegicus; See PMID 8920976; See PMID 1883325; uncharacterized protein 620706 4990643 An04g02380 Aspergillus niger uncharacterized protein XP_001401606.3 619805 D 5061 CDS An04g02390 84590828 complement(join(620882..620913,621014..621284)) VI 1 NT_166539.1 hypothetical protein 621284 84590828 An04g02390 Aspergillus niger hypothetical protein XP_059606893.1 620882 R 5061 CDS An04g02400 4990645 complement(join(621979..622499,622535..622750,622804..623138,623185..623354)) VI 1 NT_166539.1 Localization: in G2-arrested cells, dsk1 locates in the cytoplasm, whereas in mitotically arrested cells,nuclear stain is intense.; Remark: dsk1 protein may play an important role in mitotic control by altering cellular location, degree of phosphorylation and kinase activity. It auto-phosphorylates as well as phosphorylates myelin basic protein (MBP). Phosphotyrosine as well as phosphoserine/threonine were found in autophosphorylation, but no tyrosine phosphorylation occurs when MBP was used as the substrate.; Title: strong similarity to dis1-suppressing protein kinase dsk1p - Schizosaccharomyces pombe; See PMID 8485317; uncharacterized protein 623354 4990645 An04g02400 Aspergillus niger uncharacterized protein XP_059606894.1 621979 R 5061 CDS An04g02410 4990646 623806..624945 VI 1 NT_166539.1 Function: might be involved in cobalt reduction leading to cobalt(i) corrinoids.; Pathway: cobalamin biosynthesis.; Remark: strong similarity to P. denitrificans COB W patent WO9111518-A.; Title: strong similarity to cobalamin and cobamide biosynthesis protein COB W from patent WO9111518-A -Pseudomonas denitrificans; See PMID 1655697; uncharacterized protein 624945 4990646 An04g02410 Aspergillus niger uncharacterized protein XP_001401609.1 623806 D 5061 CDS An04g02420 4990647 complement(join(<625326..626374,626434..626738)) VI 1 NT_166539.1 Catalytic activity: L-ornithine = putrescine + CO2.; Pathway: urea cycle and metabolism of amino groups; arginine and proline metabolism; alkaloid biosynthesis II.; Remark: putative sequencing error at position 46804,1 bases too much.; Remark: yeast growth and mycelium-to-yeast transition in P. brasiliensis were accompanied by a high activity of ornithine decarboxylase at the onset of the budding process, the activity of which was inhibited by 1,4-diamino-2-butanone. The activity of ornithine decarboxylase remained at a basal level during vegetative growth of both the mycelial phase and the late stage of yeast phase, and also through the yeast-to-mycelium transition.; Title: strong similarity to ornithine decarboxylase ODC - Paracoccidioides brasiliensis [putative frameshift]; putative frameshift; See PMID 8661922; See PMID 9082919; uncharacterized protein 626738 4990647 An04g02420 Aspergillus niger uncharacterized protein XP_059606895.1 625326 R 5061 CDS An04g02430 84590829 complement(join(626972..627464,627510..627683,627788..627979,628060..628084,628142..628256)) VI 1 NT_166539.1 hypothetical protein 628256 84590829 An04g02430 Aspergillus niger hypothetical protein XP_059606896.1 626972 R 5061 CDS An04g02440 84590830 complement(join(629165..629635,629960..630028)) VI 1 NT_166539.1 hypothetical protein 630028 84590830 An04g02440 Aspergillus niger hypothetical protein XP_059606897.1 629165 R 5061 CDS An04g02450 4990650 complement(join(630550..634344,634439..634471)) VI 1 NT_166539.1 Title: similarity to hypothetical protein CAE76574.1 - Neurospora crassa; uncharacterized protein 634471 4990650 An04g02450 Aspergillus niger uncharacterized protein XP_059606898.1 630550 R 5061 CDS An04g02460 4990651 complement(join(634765..634809,634875..636478,636535..636649,636716..636847)) VI 1 NT_166539.1 Function: mitofilin, also known as heart muscle protein, is a mitochondrial protein. During mitochondrial in vitro import, mitofilin is proteolytically processed to the mature protein that is also detected in cellular fractions, indicating that the amino-terminal leader sequence is removed.; Similarity: the ORF overlaps with A. niger ESTs (EMBLEST:BE760804) an_0696 and (EMBLEST:BE760883) an_0869.; Similarity: the ORF shows similarity to some motor proteins, like myosin heavy chain.; Title: strong similarity to heart muscle protein mitofilin HMP - Homo sapiens; See PMID 8039717; See PMID 8886976; See PMID 9168817; uncharacterized protein 636847 4990651 An04g02460 Aspergillus niger uncharacterized protein XP_001401614.1 634765 R 5061 CDS An04g02470 4990652 complement(join(637824..638171,638235..638426,638515..638541,638602..638621,638701..638770)) VI 1 NT_166539.1 Remark: the ypt/rab proteins are a family of small GTP-binding proteins thought to be required for different stages of membrane traffic. Ypt5 protein expressed in mammalian cells colocalized with the transferrin receptor to early endosomes.; Title: strong similarity to GTP-binding protein ypt5p - Schizosaccharomyces pombe; See PMID 8226998; See PMID 8374169; uncharacterized protein 638770 4990652 An04g02470 Aspergillus niger uncharacterized protein XP_001401615.1 637824 R 5061 CDS An04g02480 4990653 join(639352..639559,639612..640181,640239..641347,641403..641579) VI 1 NT_166539.1 Remark: Sac1p shares primary sequence homology with a subfamily of cytosolic/peripheral membrane phosphoinositide phosphatases, the synaptojanins which have approximately the same lenght.; Remark: the SAC1 gene product (Sac1p) is an integral membrane protein of the endoplasmic reticulum and the Golgi complex.; Title: strong similarity to lipid phosphoinositide phosphatase Sac1 - Saccharomyces cerevisiae; See PMID 2687291; uncharacterized protein 641579 4990653 An04g02480 Aspergillus niger uncharacterized protein XP_059606899.1 639352 D 5061 CDS An04g02490 4990654 join(642315..642407,642476..642613,642694..644097) VI 1 NT_166539.1 Catalytic activity: ATP + tetrahydrofolyl-[Glu](n) + L-glutamate = ADP + orthophosphate + tetrahydrofolyl-[Glu](n+1).; Function: S. cerevisiae strains without functional met7 are methionine, adenine and thymidine auxotroph and maintenance of mitochondrial DNA is disturbed.; Localization: similar to other eukaryotes, yeasts have parallel pathways of one-carbon metabolism in the cytoplasm and mitochondria and have folylpolyglutamate synthetase activity in both compartments.; Pathway: folate biosynthesis.; Remark: alternate names are MET23, YOR241w .; Remark: one-carbon metabolism is essential to provide activated one-carbon units in the biosynthesis of methionine, purines, and thymidylate. The major forms of folates in vivo are polyglutamylated derivatives. In organisms that synthesize folate coenzymes de novo, the addition of the glutamyl side chains is achieved by the action of two enzymes, dihydrofolate synthetase and folylpolyglutamate synthetase.; Similarity: belongs to the folylpolyglutamate synthase family.; Title: strong similarity to tetrahydrofolylpolyglutamate synthase Met7 - Saccharomyces cerevisiae; See PMID 10775416; See PMID 10799479; uncharacterized protein 644097 4990654 An04g02490 Aspergillus niger uncharacterized protein XP_001401617.1 642315 D 5061 CDS An04g02500 4990655 join(644538..644591,644672..645111,645167..645950,646016..646213) VI 1 NT_166539.1 Catalytic activity: tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.; Remark: myristoyl-CoA:protein N-myristoyltransferase (Nmt) transfers myristate from CoA to the N-terminal Gly residue of cellular proteins in an ordered reaction mechanism that first involves binding of myristoyl-CoA to the apoenzyme.; Similarity: belongs to the acyltransferases.; Title: strong similarity to glycylpeptide N-tetradecanoyltransferase Nmt - Ajellomyces capsulatus; See PMID 8300631; uncharacterized protein 646213 4990655 An04g02500 Aspergillus niger uncharacterized protein XP_001401618.1 644538 D 5061 CDS An04g02510 4990656 join(646863..646911,646983..648868) VI 1 NT_166539.1 Remark: a splice site was detected upstream of the START codon.; Title: similarity to hypothetical membrane protein YOR118w - Saccharomyces cerevisiae; uncharacterized protein 648868 4990656 An04g02510 Aspergillus niger uncharacterized protein XP_059606900.1 646863 D 5061 CDS An04g02520 4990657 complement(join(649268..649905,649971..650217)) VI 1 NT_166539.1 Remark: similarity to Micrococcus luteus HexPS gene prenyl diphosphate synthetase hex2 patent EP812914-A2.; Remark: substances synthesised by PDS, i. e. polyprenyl diphosphates, are precursors of physiologically active substances, e. g. vitamin K and ubiquinones.; Title: similarity to prenyl diphosphate synthetase hex2 from patent EP812914-A2 - Micrococcus luteus; uncharacterized protein 650217 4990657 An04g02520 Aspergillus niger uncharacterized protein XP_001401620.3 649268 R 5061 CDS An04g02530 4990658 complement(join(650724..651809,651872..653072,653153..653433)) VI 1 NT_166539.1 Title: similarity to hypothetical extensin-like protein Pex2 - Zea mays; uncharacterized protein 653433 4990658 An04g02530 Aspergillus niger uncharacterized protein XP_059606901.1 650724 R 5061 CDS An04g02540 4990659 join(653878..654029,654225..654451,654518..655324,655380..655461,655601..655700,655737..655745,655870..655968) VI 1 NT_166539.1 Remark: similarity to human bladder tumour EST encoded protein 16 patent DE19818619-A1.; Remark: the predicted ORF is about 150 amino acids longer than the found homologues.; Title: similarity to bladder tumour EST encoded protein 16 from patent DE19818619-A1 - Homo sapiens; uncharacterized protein 655968 4990659 An04g02540 Aspergillus niger uncharacterized protein XP_059606902.1 653878 D 5061 CDS An04g02550 4990660 complement(join(656509..656563,656624..658653,658711..658822,658924..659132)) VI 1 NT_166539.1 Remark: disruption of the chromosomal copy of the mef1 gene in a wild-type haploid yeast induced a phenotype analogous to that of the original mutant, but does not affect cell viability. These result indicate that the gene product function exclusively in mitochondrial protein synthesis.; Similarity: to translation elongation factor G.; Title: strong similarity to mitochondrial translation elongation factor EF-G Mef1 - Saccharomyces cerevisiae; See PMID 1935960; uncharacterized protein 659132 4990660 An04g02550 Aspergillus niger uncharacterized protein XP_001401623.1 656509 R 5061 CDS An04g02560 4990661 join(659730..659813,659979..660137,660188..660247) VI 1 NT_166539.1 hypothetical protein 660247 4990661 An04g02560 Aspergillus niger hypothetical protein XP_059606903.1 659730 D 5061 CDS An04g02570 4990662 complement(join(660439..660863,660929..660999,661078..661115)) VI 1 NT_166539.1 Remark: similarity to human secreted protein, SEQ ID NO: 8043 patent EP1033401-A2.; Similarity: the ORF shows strong similarity to EST SEQ ID NO:4027 - Aspergillus niger.; Title: similarity to hypothetical membrane protein YML030w - Saccharomyces cerevisiae; uncharacterized protein 661115 4990662 An04g02570 Aspergillus niger uncharacterized protein XP_001401625.1 660439 R 5061 CDS An04g02580 4990663 join(662354..662536,662598..662814,662875..664172) VI 1 NT_166539.1 Catalytic activity: L-threonine + H2O = 2-oxobutanoate + NH3 + H2O.; Pathway: glycine, serine and threonine metabolism.; Remark: the AILV1 gene is a suitable auxotrophic selection marker in transformation experiments using an Arxula adeninivorans ilv1 mutant and a plasmid containing this gene, which is fused into the 25S rDNA of Arxula adeninivorans.; Remark: the enzyme from a number of sources also acts on L-serine.; Similarity: belongs to the threonine dehydratases.; Title: strong similarity to threonine deaminase ILV - Arxula adeninivorans; See PMID 9730281; uncharacterized protein 664172 4990663 An04g02580 Aspergillus niger uncharacterized protein XP_001401626.1 662354 D 5061 CDS An04g02590 84590831 complement(join(664385..664781,665057..665117,665200..665266)) VI 1 NT_166539.1 hypothetical protein 665266 84590831 An04g02590 Aspergillus niger hypothetical protein XP_059606904.1 664385 R 5061 CDS An04g02600 4990665 join(665925..666702,666762..666879,666966..667070,667158..667550,667615..667621) VI 1 NT_166539.1 Catalytic activity: myo-inositol hexakisphosphate + H2O = D-myo-inositol 1,2,4,5,6-pentakisphosphate + orthophosphate.; Pathway: inositol phosphate metabolism.; Remark: Aspergillus niger NRRL 3135 produces two phytases one with pH optima at 2. 5 and 5. 5 (phyA) and one with an optimum at pH 2. 0 (phyB).; Remark: phytases (myo-inositol hexakisphosphate phosphohydrolase, EC 3. 1. 3. 8) catalyse the release of phosphate from phytate (mycoinositol hexakiphosphate). Several cereal grains, legumes and oilseeds, etc., store phosphorus as phytate. Environmental pollution due to the high-phosphate manure, resulting in the accumulation of P at various locations has raised serious concerns.; Similarity: belongs to the histidine acid phosphatase family.; Title: strong similarity to 3-phytase B phyB -Aspergillus niger; See PMID 7916610; See PMID 8865587; uncharacterized protein 667621 4990665 An04g02600 Aspergillus niger uncharacterized protein XP_059606905.1 665925 D 5061 CDS An04g02610 4990666 complement(join(667829..667940,668013..669282,669352..669439,669506..669526)) VI 1 NT_166539.1 Catalytic activity: succinate semialdehyde + NAD+ or NADP+ + H2O = succinate + NADH or NADPH.; Function: in higher eucaryotes Succinate-semialdehyde dehydrogenases are required for the catabolism of GABA intermediates. Mutations of Succinate-semialdehyde dehydrogenases in higher eucaryotes give rise to central nervous system dysfunction.; Pathway: 4-aminobutyrate (GABA) degradation pathway.; Remark: in E. coli gabD is required for the utilisation of 4-hydroxyphenylacetate as nitrogene source.; Similarity: belongs to the aldehyde dehydrogenase family.; Title: strong similarity to succinate-semialdehyde dehydrogenase NAD(P)+ gabD - Escherichia coli; See PMID 2254272; See PMID 8297211; uncharacterized protein 669526 4990666 An04g02610 Aspergillus niger uncharacterized protein XP_001401629.3 667829 R 5061 CDS An04g02620 4990667 complement(join(669851..670027,670126..670280,670411..672286)) VI 1 NT_166539.1 Title: similarity to hypothetical protein CAE76577.1 - Neurospora crassa; uncharacterized protein 672286 4990667 An04g02620 Aspergillus niger uncharacterized protein XP_059606906.1 669851 R 5061 CDS An04g02630 84590832 complement(673041..>673301) VI 1 NT_166539.1 Remark: N-terminal truncated ORF due to end of contig.; Title: similarity to hypothetical membrane protein YGR103w - Saccharomyces cerevisiae [truncated ORF]; uncharacterized protein 673301 84590832 An04g02630 Aspergillus niger uncharacterized protein XP_059606907.1 673041 R 5061 CDS An04g02640 4990669 complement(join(<673404..673515,673573..674695,674772..674870,674932..674953)) VI 1 NT_166539.1 Remark: pes mRNA is expressed widely and dynamically during the first 3 days of embryogenesis.; Title: strong similarity to protein pescadillo -Homo sapiens; See PMID 8985183; uncharacterized protein 674953 4990669 An04g02640 Aspergillus niger uncharacterized protein XP_059606041.1 673404 R 5061 CDS An04g02650 4990670 join(675240..675381,675437..675501,675551..675753,675804..676426,676476..676714) VI 1 NT_166539.1 Remark: CECRPs are activators of cell proliferation or inhibitors of cellular processes that modulate proliferation.; Remark: the patent does not provide further information about the function of the protein.; Remark: the sequence of human cell cycle regulation protein-4 (CECRP-4) is also covered by patents WO200058473-A2 (AC# AAB43252) and WO200017222-A1 (AC# AAB08956). the latter claims the protein to be secreted.; Similarity: the predicted A. niger protein shows strong similarity to the protein sequence of human cell cycle regulation protein-4 (CECRP-4) of patent WO9964593-A2 (AC# AAY44363), strong similarity to the hypothetical cell division control protein CDC91 from S. cerevisiae and other hypothetical proteins from diverse eucaryotic species.; Title: strong similarity to cell cycle regulation protein-4 (CECRP-4) from patent WO9964593-A2 - Homo sapiens; uncharacterized protein 676714 4990670 An04g02650 Aspergillus niger uncharacterized protein XP_001401633.1 675240 D 5061 CDS An04g02660 4990671 complement(join(676775..677466,677563..677695)) VI 1 NT_166539.1 Title: similarity to hypothetical protein SPCC825.04c - Schizosaccharomyces pombe; uncharacterized protein 677695 4990671 An04g02660 Aspergillus niger uncharacterized protein XP_001401634.1 676775 R 5061 CDS An04g02670 4990672 complement(join(678132..678301,678350..678495,678546..678601,678660..678941,678989..679093,679163..679309,679362..679430)) VI 1 NT_166539.1 Function: catalyzes the reduction of a wide range of aldehydes (but not e. g. acetaldehyde) and ketones.; Remark: may be involved in detoxification of reactive carbonyl-containing compounds.; Title: strong similarity to NADPH-dependent aldehyde reductase - Sporobolomyces salmonicolor; See PMID 1633196; uncharacterized protein 679430 4990672 An04g02670 Aspergillus niger uncharacterized protein XP_001401635.1 678132 R 5061 CDS An04g02680 84590833 join(679852..680034,680273..680323,680382..680427,680568..680585,680699..680871) VI 1 NT_166539.1 hypothetical protein 680871 84590833 An04g02680 Aspergillus niger hypothetical protein XP_059606042.1 679852 D 5061 CDS An04g02690 4990674 join(681354..681515,681580..681969,682033..682479,682536..682580) VI 1 NT_166539.1 Remark: the ADH sequence 19 protein is part of the patent EP0845532 with the title: 'enzymes for the synthesis of coniferyl alcohol, coniferyl aldehyde, ferulic acid,vanillin, vanillic acid and their applications'.; Remark: the organism of patent EP0845532 remains unclassified.; Title: strong similarity to alcohol dehydrogenase ADH from patent EP0845532-A - Unclassified organism; uncharacterized protein 682580 4990674 An04g02690 Aspergillus niger uncharacterized protein XP_001401637.1 681354 D 5061 CDS An04g02700 4990675 join(683119..683316,683374..685995) VI 1 NT_166539.1 Function: Raffinose synthase is involved in the biosynthesis of raffinose and higher homologues in the raffinose saccharide family from sucrose.; Similarity: shows also similarities to imbibition proteins of a variety of plants whsoe sequences are not yet published.; Title: similarity to wheat raffinose synthase from patent WO200024915-A2 - Triticum aestivum; uncharacterized protein 685995 4990675 An04g02700 Aspergillus niger uncharacterized protein XP_001401638.1 683119 D 5061 CDS An04g02710 4990676 complement(join(686533..688131,688183..688245)) VI 1 NT_166539.1 Function: the murine beta-carotene 15,15'-dioxygenase beta-CD cleaves beta-carotene to all-trans-retinal (vitamin A).; Title: strong similarity to beta-carotene 15,15-dioxygenase beta-CD - Mus musculus; See PMID 11092891; uncharacterized protein 688245 4990676 An04g02710 Aspergillus niger uncharacterized protein XP_001401639.1 686533 R 5061 CDS An04g02720 4990677 complement(join(689887..691022,691674..691924,691964..692189,692243..692305,692352..692694,692747..692791,692839..693056,693110..693221,693273..693491)) VI 1 NT_166539.1 Similarity: the human BNPI transporter is identical to the protein described in patent WO9838203-A1.; Title: similarity to brain-specific Na-dependent inorganic phosphate cotransporter BNPI - Homo sapiens; plasma membrane; See PMID 9786972; See PMID 10820226; See PMID 8202535; uncharacterized protein 693491 4990677 An04g02720 Aspergillus niger uncharacterized protein XP_059606043.1 689887 R 5061 CDS An04g02730 4990678 join(695418..695468,695583..696431) VI 1 NT_166539.1 Function: the ribonuclease H (RnhA) from Escherichia coli is an endonuclease that degrades the RNA of RNA-DNA hybrids specifically. In E. coli RNAse H participates in DNA replication. It helps to specify the origin of genomic replication by suppressing initiation at origins other than the locus oriC. Along with the 5'-3' exonuclease of DNAPol1, it removes RNA primers from the Okazaki-fragments of lagging strand synthesis and it defines the origin of replication for cole1-type plasmids by specific cleavage of an RNA preprimer.; Similarity: the ORF DNA sequence shows also strong similarity to the sequence of EST an_2834 from Aspergillus niger.; Title: similarity to ribonuclease H rnhA -Escherichia coli; See PMID 2171503; See PMID 6302075; See PMID 6316347; uncharacterized protein 696431 4990678 An04g02730 Aspergillus niger uncharacterized protein XP_001401641.3 695418 D 5061 CDS An04g02740 84590834 complement(697607..700918) VI 1 NT_166539.1 Function: the human HUPF1 protein plays an important role in the nonsense-mediated mRNA decay (NMD). It displays a nucleic-acid-dependent ATPase activity and a 5'--> 3' helicase activity.; Title: similarity to nonsense mRNA-reducing protein Hupf1 - Homo sapiens; cytoplasm; See PMID 10999600; See PMID 9064659; uncharacterized protein 700918 84590834 An04g02740 Aspergillus niger uncharacterized protein XP_059606044.1 697607 R 5061 CDS An04g02750 84590835 complement(join(702614..703042,703320..703517)) VI 1 NT_166539.1 Title: weak similarity to glycinin A5A4B3 subunit from patent JP61132189-A - Glycine max; uncharacterized protein 703517 84590835 An04g02750 Aspergillus niger uncharacterized protein XP_059606045.1 702614 R 5061 CDS An04g02760 4990681 join(<704188..704363,704417..704638,704688..705148,705199..>705414) VI 1 NT_166539.1 Function: the E. coli RspA protein is probably involved in the degradation of homoserine lactone, which may be a general signal of starvation.; Title: strong similarity to starvation-sensing protein rspA - Escherichia coli; See PMID 7545940; uncharacterized protein 705414 4990681 An04g02760 Aspergillus niger uncharacterized protein XP_001401644.3 704188 D 5061 CDS An04g02770 4990682 join(705678..705794,705857..706069,706153..706535,706693..706719,706806..706851) VI 1 NT_166539.1 Catalytic activity: 2-deoxy-D-gluconate + NAD(+) <=> 3-dehydro-2-deoxy-D-gluconate + NADH.; Pathway: the KduD protein from Erwinia chrysanthemi involved in the pentose and glucuronate interconversions.; Title: strong similarity to 2-deoxy-D-gluconate 3-dehydrogenase KduD - Erwinia chrysanthemi; See PMID 1766386; uncharacterized protein 706851 4990682 An04g02770 Aspergillus niger uncharacterized protein XP_059606046.1 705678 D 5061 CDS An04g02780 4990683 709180..710799 VI 1 NT_166539.1 Function: the PVA enzyme described in patent US5516679-A is used for the enzymatic hydrolysis of penicillin V (phenoxy-methylpenicillin) to 6-aminopenicillanic acid (6-APA). 6-APA is the active beta-lactam nucleus used in the manufacture of semi-synthetic penicillins.; Similarity: the ORF encoded protein shows strong similarity to the tannase fromAspergillus oryzae (Pubmed 8917102).; Title: strong similarity to penicillin V amidohydrolase PVA from patent US5516679-A - Fusarium oxysporum; uncharacterized protein 710799 4990683 An04g02780 Aspergillus niger uncharacterized protein XP_059606047.1 709180 D 5061 CDS An04g02790 4990684 join(712353..712479,712542..713613,713711..714055,714091..714129,714188..714341) VI 1 NT_166539.1 Function: Lac12 from K. lactis mediates the transport of lactose and it would appear that the permease works in part by a proton symport mechanism.; Title: strong similarity to lactose permease Lac12 -Kluyveromyces lactis; plasma membrane; See PMID 3053697; uncharacterized protein 714341 4990684 An04g02790 Aspergillus niger uncharacterized protein XP_059606048.1 712353 D 5061 CDS An04g02800 4990685 join(715395..715950,716029..716333) VI 1 NT_166539.1 Catalytic activity: L-proline + NAD(P)(+) <=> 1-pyrroline-5-carboxylate + NAD(P)H.; Pathway: ProC from Pseudomonas aeruginosa catalyzes the terminal (third) step in proline biosynthesis.; Title: strong similarity to pyrroline-5-carboxylate reductase ProC - Pseudomonas aeruginosa; See PMID 2107123; uncharacterized protein 716333 4990685 An04g02800 Aspergillus niger uncharacterized protein XP_001401648.1 715395 D 5061 CDS An04g02810 84590836 716705..717604 VI 1 NT_166539.1 Title: weak similarity to choline kinase from patent WO9812346-A1 - Streptococcus pneumoniae; uncharacterized protein 717604 84590836 An04g02810 Aspergillus niger uncharacterized protein XP_059606049.1 716705 D 5061 CDS An04g02820 4990686 718527..719054 VI 1 NT_166539.1 hypothetical protein 719054 4990686 An04g02820 Aspergillus niger hypothetical protein XP_001401649.3 718527 D 5061 CDS An04g02830 4990688 complement(join(<719350..719937,720005..720468,720516..720582,720630..720840,720885..721103)) VI 1 NT_166539.1 Function: the S. cerevisiae Tna1 transporter is involved in the uptake of nicotinic acid.; Remark: a putative frameshift results in a premature STOP codon.; Remark: alternate name for S. cerevisiae Tna1: YGR260W.; Similarity: the ORF encoded protein shows also strong similarity to the allantoate transporter Dal5/YJR152W from S. cerevisiae, but the accessible literature does not describe any functional characterization of Dal5 (Pubmed 3275614).; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae [putative frameshift]; putative frameshift; See PMID 10869563; uncharacterized protein 721103 4990688 An04g02830 Aspergillus niger uncharacterized protein XP_059606050.1 719350 R 5061 CDS An04g02840 4990689 join(721347..721437,721484..722503,722557..722895,722969..>723032) VI 1 NT_166539.1 Catalytic activity: (S)-lactate + 2 ferricytochrome c <=> pyruvate + 2 ferrocytochrome c.; Cofactor: FMN; Protoheme IX.; Localization: the L-lactate dehydrogenase CYB2 from Pichia anomala is localized in the mitochondrial intermembrane space.; Remark: Pichia anomala=Hansenula anomala.; Remark: a putative frameshift results in a premature STOP codon.; Title: strong similarity to flavocytochrome b2 L-lactate dehydrogenase CYB2 - Pichia anomala [putative frameshift]; localisation:mitochondrion; putative frameshift; See PMID 3319613; See PMID 2688640; See PMID 2813072; uncharacterized protein 723032 4990689 An04g02840 Aspergillus niger uncharacterized protein XP_059606051.1 721347 D 5061 CDS An04g02850 4990690 join(723314..723424,723484..724229,724281..725415) VI 1 NT_166539.1 Function: the X-Pro dipeptidyl-peptidase IV -Xanthomonas maltophilia cleaves Xaa-Pro-|- bonds to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-|-P-nitroanilide and (sequentially) Tyr-Pro-|-Phe-Pro-|-Gly-Pro-|-Ile.; Remark: Xanthomonas maltophilia=Stenotrophomonas maltophilia.; Remark: the X-Pro dipeptidyl-peptidase IV from Xanthomonas maltophilia can be inhibited by diisopropyl phosphofluoridate.; Title: similarity to X-Pro dipeptidyl-peptidase IV -Xanthomonas maltophilia; See PMID 9010758; uncharacterized protein 725415 4990690 An04g02850 Aspergillus niger uncharacterized protein XP_001401653.1 723314 D 5061 CDS An04g02870 84590837 complement(join(727597..728130,728182..728607)) VI 1 NT_166539.1 Remark: a splice site was detected upstream of the START codon.; Title: weak similarity to histone H1 - Nicotiana tabacum; uncharacterized protein 728607 84590837 An04g02870 Aspergillus niger uncharacterized protein XP_059606052.1 727597 R 5061 CDS An04g02880 4990693 complement(728901..730106) VI 1 NT_166539.1 Catalytic activity: L-glutaminyl-peptide <=> 5-oxoprolyl-peptide + NH(3).; Function: the human glutaminyl-peptide cyclotransferase QPCT is responsible for the biosynthesis of pyroglutamyl peptides. It has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue.; Title: strong similarity to glutaminyl-peptide cyclotransferase QPCT - Homo sapiens; See PMID 7999256; uncharacterized protein 730106 4990693 An04g02880 Aspergillus niger uncharacterized protein XP_001401655.1 728901 R 5061 CDS An04g02890 4990694 join(730490..730709,730773..730934,730985..731403) VI 1 NT_166539.1 Title: weak similarity to LP-76-related adaptor molecule Clnk - Mus musculus; uncharacterized protein 731403 4990694 An04g02890 Aspergillus niger uncharacterized protein XP_001401656.1 730490 D 5061 CDS An04g02900 4990695 join(731743..731847,731899..732236,732294..732486) VI 1 NT_166539.1 Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: weak similarity to nucleolar phosphoprotein xNopp180 - Xenopus laevis; uncharacterized protein 732486 4990695 An04g02900 Aspergillus niger uncharacterized protein XP_001401657.1 731743 D 5061 CDS An04g02910 4990696 complement(join(733924..734280,734344..734841)) VI 1 NT_166539.1 Similarity: the ORF encoded protein shows significant similarity to some conserved hypothetical proteins e. g PA2764 (Pseudomonas aeruginosa).; Title: weak similarity to nitrogenase 2 vanadium-iron protein beta chain - Azotobacter vinelandii; uncharacterized protein 734841 4990696 An04g02910 Aspergillus niger uncharacterized protein XP_001401658.1 733924 R 5061 CDS An04g02920 84590838 complement(735991..736473) VI 1 NT_166539.1 Title: weak similarity to hypothetical protein CG3556 - Drosophila melanogaster; uncharacterized protein 736473 84590838 An04g02920 Aspergillus niger uncharacterized protein XP_059606053.1 735991 R 5061 CDS An04g02930 4990698 complement(join(737829..738354,738422..738798,738858..739145)) VI 1 NT_166539.1 Function: Pth11 from M. grisea is involved in surface dependent signal transduction during plant infection. Pth11 can activate appressorium differentiation in response to inductive surface cues and repress differentiation on poorly inductive surfaces.; Remark: the filamentous ascomycete Magnaporthe grisea is the blast pathogen of many grass species,including rice.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529; uncharacterized protein 739145 4990698 An04g02930 Aspergillus niger uncharacterized protein XP_001401660.1 737829 R 5061 CDS An04g02940 4990699 complement(join(740206..740261,740391..741201)) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein B24P7.350 - Neurospora crassa; uncharacterized protein 741201 4990699 An04g02940 Aspergillus niger uncharacterized protein XP_001401661.3 740206 R 5061 CDS An04g02950 4990700 join(741517..741952,742002..742348,742418..742835,742894..743034,743091..743281) VI 1 NT_166539.1 Function: TRI11 (F. s.) catalyzes the hydroxylation at C-15 of isotricodermin.; Pathway: the TRI11 enzyme from F. sporotrichioides is involved trichothecene biosynthesis. Trichothecenes are sesquiterpenoid toxins that act by inhibiting protein biosynthesis.; Similarity: TRI11 (F. s.) belongs to the cytochrome p450 family.; Title: strong similarity to cytochrome P450 monooxygenase TRI11 - Fusarium sporotrichioides; See PMID 9435078; uncharacterized protein 743281 4990700 An04g02950 Aspergillus niger uncharacterized protein XP_059606054.1 741517 D 5061 CDS An04g02960 84590839 join(745638..745676,745832..745953,746076..746100) VI 1 NT_166539.1 hypothetical protein 746100 84590839 An04g02960 Aspergillus niger hypothetical protein XP_059606055.1 745638 D 5061 CDS An04g02970 4990702 complement(join(746851..746907,746972..747130,747162..748514)) VI 1 NT_166539.1 Catalytic activity: N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)O.; Function: FMO is involved in the metabolism of many drugs, pesticides, and other foreign compounds, including xenobiotics, by catalyzing the NADPH-dependent oxidation of various substrates.; Title: similarity to dimethylaniline monooxygenase FMO - Sus scrofa; See PMID 2322534; See PMID 2383273; uncharacterized protein 748514 4990702 An04g02970 Aspergillus niger uncharacterized protein XP_059606056.1 746851 R 5061 CDS An04g02980 4990703 complement(join(750377..751771,751839..752048)) VI 1 NT_166539.1 Catalytic activity: AAO uses oxygen as an acceptor to produce hydrogen peroxide from primary aromatic or poly-unsaturated aliphatic alcohols.; Function: Aryl-alcohol oxidase (AAO) is involved in lignin degradation by Pleurotus pulmonarius.; Remark: AAO is an extracellular glycoprotein with 14% N-carbohydrate content.; Title: strong similarity to aryl-alcohol oxidase precursor aao - Pleurotus pulmonarius; See PMID 10606774; uncharacterized protein 752048 4990703 An04g02980 Aspergillus niger uncharacterized protein XP_001401665.1 750377 R 5061 CDS An04g02990 4990704 complement(join(752735..753161,753222..753595,753656..753760,753811..753960)) VI 1 NT_166539.1 Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea; uncharacterized protein 753960 4990704 An04g02990 Aspergillus niger uncharacterized protein XP_001401666.1 752735 R 5061 CDS An04g03000 84590840 complement(join(755543..756204,756261..756921)) VI 1 NT_166539.1 Function: ankyrins are linker proteins, which connect various membrane proteins with the submembranous actin-spectrin skeleton.; Remark: truncated ORF due to the contig end.; Title: similarity to ankyrin Ank2 - Drosophila melanogaster [truncated ORF]; See PMID 7937942; See PMID 10844021; uncharacterized protein 756921 84590840 An04g03000 Aspergillus niger uncharacterized protein XP_059603588.1 755543 R 5061 CDS An04g03010 4990706 complement(757877..758473) VI 1 NT_166539.1 Remark: MP1 has high affinity for concanavalin A, a characteristic indicative of a mannoprotein.; Title: similarity to cell wall antigen MP1 -Penicillium marneffei; cell wall; See PMID 9488383; See PMID 9738061; uncharacterized protein 758473 4990706 An04g03010 Aspergillus niger uncharacterized protein XP_001401668.1 757877 R 5061 CDS An04g03030 84590841 complement(760619..761671) VI 1 NT_166539.1 Function: radixins are ross-linkers between plasma membranes and actin-based cytoskeletons.; Remark: protein is shorter at the N-terminus than the database proteins.; Remark: the ERM family consists of three closely related proteins, ezrin, radixin, and moesin.; Title: similarity to radixin - Sus scrofa; cytoskeleton; See PMID 8268231; See PMID 9013673; See PMID 10574907; uncharacterized protein 761671 84590841 An04g03030 Aspergillus niger uncharacterized protein XP_059603589.1 760619 R 5061 CDS An04g03040 84590842 join(762321..762407,762461..762901) VI 1 NT_166539.1 Title: weak similarity to hypothetical late embryonic abundant protein EMB23 - Picea glauca; uncharacterized protein 762901 84590842 An04g03040 Aspergillus niger uncharacterized protein XP_059603590.1 762321 D 5061 CDS An04g03050 4990710 complement(join(764304..765002,765068..767454,767503..767665,767838..768170)) VI 1 NT_166539.1 Alternative name: MSH6, PMS3, YDR097C.; Complex: forms complex with Msh2p to repair both single-base and insertion-deletion mispairs in yeast.; Function: required for mismatch repair in mitosis and meiosis in yeast.; Title: strong similarity to DNA mismatch repair protein Msh6 - Saccharomyces cerevisiae; nucleus; See PMID 8600025; See PMID 8723353; See PMID 8816473; uncharacterized protein 768170 4990710 An04g03050 Aspergillus niger uncharacterized protein XP_059603591.1 764304 R 5061 CDS An04g03060 4990711 complement(join(768945..769661,769717..770062,770115..770398,770452..770605,770686..771020)) VI 1 NT_166539.1 Catalytic activity: ATP + L-tyrosine + tRNA(Tyr) = AMP + pyrophosphate + L-tyrosyl-tRNA(Tyr).; Function: the protein CYT-18 of Neurospora crassa has two functions: aminoacyl-tRNA synthetase and is involved in the splicing of group I introns.; Remark: it acts in intron splicing by stabilizing the catalytically active structure of the intron.; Title: strong similarity to mitochondrial tyrosine--tRNA ligase CYT-18 - Neurospora crassa; localisation:mitochondrion; See PMID 2143700; See PMID 3607872; uncharacterized protein 771020 4990711 An04g03060 Aspergillus niger uncharacterized protein XP_001401673.1 768945 R 5061 CDS An04g03070 4990712 join(772054..772220,772299..772617,772789..773234,773283..774372) VI 1 NT_166539.1 Title: similarity to hypothetical transcription activator SPAC139.03 - Schizosaccharomyces pombe; uncharacterized protein 774372 4990712 An04g03070 Aspergillus niger uncharacterized protein XP_059603592.1 772054 D 5061 CDS An04g03080 4990713 complement(join(774514..775660,775761..775977,776034..776090,776149..776302)) VI 1 NT_166539.1 Remark: the Na(+)-hypersensitive phenotype of the hol1-mutation is correlated with increased uptake and accumulation of this ion in yeast.; Title: similarity to multidrug resistance protein Hol1 - Saccharomyces cerevisiae; See PMID 8955402; See PMID 2405251; uncharacterized protein 776302 4990713 An04g03080 Aspergillus niger uncharacterized protein XP_059603593.1 774514 R 5061 CDS An04g03090 4990714 complement(join(776896..777604,777665..777993)) VI 1 NT_166539.1 Title: similarity to hypothetical protein SC1C3.21 -Streptomyces coelicolor; uncharacterized protein 777993 4990714 An04g03090 Aspergillus niger uncharacterized protein XP_001401676.1 776896 R 5061 CDS An04g03100 4990715 778542..780314 VI 1 NT_166539.1 Catalytic activity: cocaine is hydrolyzed to ecgonine methyl ester and benzoate.; Function: the cocaine esterase was found to initiate degradation of cocaine in Rhodococcus sp.; Remark: Rhodococcus sp. utilizes cocaine as a sole source of carbon and nitrogen for growth.; Title: strong similarity to cocaine esterase cocE -Rhodococcus sp.; See PMID 10698749; uncharacterized protein 780314 4990715 An04g03100 Aspergillus niger uncharacterized protein XP_001401677.1 778542 D 5061 CDS An04g03110 4990716 join(781060..781264,781366..782075,782126..783191,783261..783270,783346..783391,783526..783561) VI 1 NT_166539.1 Catalytic activity: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp).; Remark: MSD1 is a nuclear gene.; Title: strong similarity to mitochondrial aspartate--tRNA ligase Msd1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 10710420; See PMID 2668951; uncharacterized protein 783561 4990716 An04g03110 Aspergillus niger uncharacterized protein XP_001401678.3 781060 D 5061 CDS An04g03120 4990717 complement(783665..785239) VI 1 NT_166539.1 Function: Cox10 is required for the synthesis of cytochrome oxidase in yeast, espacially needed for heme A synthesis.; Remark: nuclear gene.; Similarity: shows also similarity to heme A farnesyltransferases.; Title: strong similarity to assembly factor of cytochrome c oxidase Cox10 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8078902; See PMID 8118433; uncharacterized protein 785239 4990717 An04g03120 Aspergillus niger uncharacterized protein XP_001401679.1 783665 R 5061 CDS An04g03130 4990718 join(785491..786117,786168..786443) VI 1 NT_166539.1 Remark: a lec35 mutation of Chinese hamster affects the participation of mannose-P-dolichol (MPD) in dolichol-P-P-oligosaccharide biosynthesis in vivo.; Remark: lec35 mutations are mannosylation-defective in Chinese hamster ovarian cells.; Remark: stop codon at position 26450-26448.; Title: strong similarity to mannosylation protein Lec35 - Cricetulus griseus [putative sequencing error]; putative sequencing error; See PMID 8454644; See PMID 8454645; See PMID 11179430; uncharacterized protein 786443 4990718 An04g03130 Aspergillus niger uncharacterized protein XP_059603594.1 785491 D 5061 CDS An04g03140 4990719 complement(join(786532..787216,787291..787415)) VI 1 NT_166539.1 Alternative name: MED8, YBR193c.; Complex: specifically binds to upstream activating sequences (UASs) of SUC2 promoter, to downstream repressing sequences (DRSs) of the HXK2 gene and to the carboxy-terminal domain of the RNA polymerase II in yeast.; Function: Med8 act as coupling factor by linking activating and repressing transcription complexes to the RNA polymerase II holoenzyme transcriptional machinery in yeast.; Title: similarity to transcription factor Med8 -Saccharomyces cerevisiae; nucleus; See PMID 9918841; See PMID 10526178; uncharacterized protein 787415 4990719 An04g03140 Aspergillus niger uncharacterized protein XP_059603595.1 786532 R 5061 CDS An04g03150 4990720 complement(788432..789568) VI 1 NT_166539.1 Title: weak similarity to hypothetical protein SPCP31B10.04 - Schizosaccharomyces pombe; uncharacterized protein 789568 4990720 An04g03150 Aspergillus niger uncharacterized protein XP_001401682.1 788432 R 5061 CDS An04g03160 4990721 join(791487..791880,791939..792987) VI 1 NT_166539.1 Remark: only weak partial similarity to aminomethyltransferase from the yeast S. cerevisiae.; Similarity: the ORF shows strong similarity to the A. niger protein An07g04910. The similarity between the two proteins, however, is restricted to a stretch of about 130 amino acids.; Title: similarity to hypothetical protein encoded by An07g04910 - Aspergillus niger; uncharacterized protein 792987 4990721 An04g03160 Aspergillus niger uncharacterized protein XP_001401683.1 791487 D 5061 CDS An04g03170 4990722 join(793795..795536,795670..795680,795862..796064) VI 1 NT_166539.1 Catalytic activity: hydrolysis of terminal,non-reducing beta-D-glucose residues with release of beta-D-glucose.; Function: yeast Candida wickerhamii exports a cell-associated beta-glucosidase that is active against cellobiose and all soluble cellodextrins.; Title: strong similarity to beta-glucosidase bglB -Candida wickerhamii; See PMID 8929394; See PMID 7574590; uncharacterized protein 796064 4990722 An04g03170 Aspergillus niger uncharacterized protein XP_001401684.3 793795 D 5061 CDS An04g03180 4990723 complement(join(796882..797378,797433..797672,797722..798028)) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein EAA64005.1 - Aspergillus nidulans; uncharacterized protein 798028 4990723 An04g03180 Aspergillus niger uncharacterized protein XP_001401685.1 796882 R 5061 CDS An04g03190 84590843 complement(799228..800016) VI 1 NT_166539.1 Title: weak similarity to hypothetical protein F28C11.17 - Arabidopsis thaliana; uncharacterized protein 800016 84590843 An04g03190 Aspergillus niger uncharacterized protein XP_059603596.1 799228 R 5061 CDS An04g03195 84590844 join(802332..802435,802496..802505) VI 1 NT_166539.1 hypothetical protein 802505 84590844 An04g03195 Aspergillus niger hypothetical protein XP_059603597.1 802332 D 5061 CDS An04g03200 4990726 complement(join(803301..804242,804316..804456,804517..804618,804679..804717)) VI 1 NT_166539.1 Catalytic activity: D-mannose 6-phosphate = D-fructose 6-phosphate.; Remark: protein is involved in the synthesis of GDP-mannose and dolichol-phosphate mannose in mannosyl transfer reactions in the glycosylation and mannosylation pathways.; Title: strong similarity to mannose-6-phosphate isomerase manA - Candida albicans; See PMID 8180205; See PMID 7702743; See PMID 7785330; uncharacterized protein 804717 4990726 An04g03200 Aspergillus niger uncharacterized protein XP_001401688.1 803301 R 5061 CDS An04g03210 4990727 complement(805416..806237) VI 1 NT_166539.1 Title: weak similarity to protein E2 - Human papillomavirus type 76; uncharacterized protein 806237 4990727 An04g03210 Aspergillus niger uncharacterized protein XP_001401689.1 805416 R 5061 CDS An04g03220 4990728 complement(join(809679..810918,810986..811830,811901..812164)) VI 1 NT_166539.1 Title: similarity to hypothetical protein YKR089c -Saccharomyces cerevisiae; uncharacterized protein 812164 4990728 An04g03220 Aspergillus niger uncharacterized protein XP_001401690.1 809679 R 5061 CDS An04g03230 84590845 join(812205..812363,812439..812657) VI 1 NT_166539.1 hypothetical protein 812657 84590845 An04g03230 Aspergillus niger hypothetical protein XP_059603598.1 812205 D 5061 CDS An04g03240 84590846 complement(join(812702..812755,812799..812902,812980..813050,813121..813316,813401..813466,813550..813650,813730..>813950)) VI 1 NT_166539.1 Remark: truncated due to contig end.; hypothetical protein [truncated ORF] 813950 84590846 An04g03240 Aspergillus niger hypothetical protein [truncated ORF] XP_059603599.1 812702 R 5061 CDS An04g03250 4990731 complement(join(<814067..816258,816323..817370,817427..817816)) VI 1 NT_166539.1 Function: co-expression of het-e and het-c leads to cell death.; Function: het-e1 of P. anserina is responsible for vegetative incompatibility.; Remark: het-e1 of P. anserina shows two sequence motifs, a GTP-binding domain and a repeated region that shares similarity with that of the beta-transducin.; Remark: the reactivity of the HET-E protein depends on two functional elements, a GTP-binding domain and several WD40 repeats.; Remark: truncated ORF due to the contig end.; Title: similarity to beta transducin-like protein het-e1 - Podospora anserina [truncated ORF]; See PMID 7557402; See PMID 9435787; See PMID 10875280; See PMID 10974123; uncharacterized protein 817816 4990731 An04g03250 Aspergillus niger uncharacterized protein XP_059600480.1 814067 R 5061 CDS An04g03260 4990732 complement(818236..819612) VI 1 NT_166539.1 Remark: general weak similarity to several different proteins involved in protein-protein interaction.; Similarity: weak similarity to desmoplakin I and centrosome associated protein CEP250 from H. sapiens.; Title: weak similarity to myosin heavy chain - Homo sapiens; uncharacterized protein 819612 4990732 An04g03260 Aspergillus niger uncharacterized protein XP_001401694.1 818236 R 5061 CDS An04g03270 4990733 join(820088..820227,820334..820503,820566..821092,821149..823407,823474..823821) VI 1 NT_166539.1 Complex: the 26S proteasome of S. cerevisiae contains a 20S catalytic core and a 19S regulatory subunit.; Function: regulatory subunit of the 26S proteasome of S. cerevisiae.; Function: the 26S proteasome degrades ubiquinated proteins.; Title: strong similarity to proteasome 19S regulatory particle subunit Rpn2 - Saccharomyces cerevisiae; nucleus; uncharacterized protein 823821 4990733 An04g03270 Aspergillus niger uncharacterized protein XP_001401695.1 820088 D 5061 CDS An04g03280 84590847 join(824457..824695,824941..825160) VI 1 NT_166539.1 hypothetical protein 825160 84590847 An04g03280 Aspergillus niger hypothetical protein XP_059600481.1 824457 D 5061 CDS An04g03290 4990735 join(825460..825574,825647..825658,825720..825991,826077..826821,826877..827370) VI 1 NT_166539.1 Catalytic activity: acyl-CoA + ETF <=> 2,3-dehydroacyl-CoA + reduced ETF.; Complex: forms with another flavoprotein (ETF = 'Electron-Transferring Flavoprotein') and EC 1. 5. 5. 1 a system reducing ubiquinone and other acceptors.; Localization: mitochondrial matrix in Rattus norvegicus.; Pathway: initial step of the mitochondrial fatty acid beta-oxidation system.; Remark: a number of acyl-CoA dehydrogenases of different substrate specifity are present in all organisms.; Remark: closest manual homolog (BLASTP): PIR:A34252 long-chain-acyl-CoA dehydrogenase precursor - Rattus norvegicus.; Title: strong similarity to long-chain acyl-CoA dehydrogenase - Rattus norvegicus; localisation:mitochondrion; See PMID 2777793; See PMID 8268228; See PMID 10760462; uncharacterized protein 827370 4990735 An04g03290 Aspergillus niger uncharacterized protein XP_001401697.1 825460 D 5061 CDS An04g03300 4990736 join(828277..828375,828433..828651,828715..830195,830246..830988,831044..831660) VI 1 NT_166539.1 Complex: SPT4 and SPT5 from S. cerevisiae form a complex that does not contain SPT6.; Function: STP5 from S. cerevisiae is a transcription elongation protein.; Title: strong similarity to transcription elongation protein Spt5 - Saccharomyces cerevisiae; nucleus; uncharacterized protein 831660 4990736 An04g03300 Aspergillus niger uncharacterized protein XP_059600482.1 828277 D 5061 CDS An04g03310 4990737 complement(join(832411..833139,833240..834802)) VI 1 NT_166539.1 Remark: high proline and glutamine content is indicative for various polynucleotide-binding domains.; Similarity: N-terminal region with high proline and glutamine content shows similarities to different DNA-directed RNA polymerases, C-terminal region shows similarity to mRNA-capping-enzyme of S. pombe.; Title: similarity to hypothetical mRNA-capping enzyme subunit SPAC644.04 - Schizosaccharomyces pombe; See PMID 9345280; uncharacterized protein 834802 4990737 An04g03310 Aspergillus niger uncharacterized protein XP_059600483.1 832411 R 5061 CDS An04g03320 4990738 complement(join(836119..836546,836604..836678,836739..837339,837409..837855)) VI 1 NT_166539.1 Function: TTG1 is potentially involved in signal transduction to downstream transcription factors in A. thaliana.; Function: protein regulates the trichome differentiation and anthocyanin biosynthesis in Arabidopsis thaliana.; Similarity: strong similarity to hypothetical protein YPL247 form S. cerevisiae.; Similarity: strong similarity to putative beta transducin from S. pombe.; Similarity: ttg1 from A. thaliana contains four WD40 repeats.; Title: similarity to transparent testa glabra1 TTG1 - Arabidopsis thaliana; See PMID 10402433; uncharacterized protein 837855 4990738 An04g03320 Aspergillus niger uncharacterized protein XP_001401700.3 836119 R 5061 CDS An04g03330 4990739 838795..840000 VI 1 NT_166539.1 Title: strong similarity to hypothetical protein SPAC1F12.08 - Schizosaccharomyces pombe; uncharacterized protein 840000 4990739 An04g03330 Aspergillus niger uncharacterized protein XP_001401701.1 838795 D 5061 CDS An04g03340 84590848 join(841704..841892,842005..843174,843449..843482,843572..843582,843615..843617) VI 1 NT_166539.1 Title: weak similarity to hypothetical syntaxin 8 related protein B13N20.240 - Neurospora crassa; uncharacterized protein 843617 84590848 An04g03340 Aspergillus niger uncharacterized protein XP_059600484.1 841704 D 5061 CDS An04g03350 4990741 complement(join(843928..846148,846185..846576)) VI 1 NT_166539.1 Function: Ral2 from S. pombe probably is a GDP - GTP exchange factor for Ras1; Phenotype: deletion mutant shows no response to the mating pheromone, but their vegetative growth was apparently normal in S. pombe.; Title: similarity to ras1 activating gene ral2p -Schizosaccharomyces pombe; uncharacterized protein 846576 4990741 An04g03350 Aspergillus niger uncharacterized protein XP_059600485.1 843928 R 5061 CDS An04g03360 4990742 complement(join(848500..848756,848815..849067,849150..849258,849323..849342)) VI 1 NT_166539.1 Catalytic activity: Phosphatidylcholine + H(2)O <=> 1-acylglycerophosphocholine + a fatty acid anion.; Function: aiPLA2 degrades internalized phosphatidylcholine in R. norvegicus.; Localization: in lysosomal fraction of R. norvegicus lung epithelium.; Title: strong similarity to acidic Ca(2+)-independent phospholipase A2 aiPLA2 - Rattus norvegicus; See PMID 9612290; uncharacterized protein 849342 4990742 An04g03360 Aspergillus niger uncharacterized protein XP_001401704.3 848500 R 5061 CDS An04g03370 84590849 complement(join(849386..849812,849993..850197,850601..851042,851720..851869,851976..852095)) VI 1 NT_166539.1 hypothetical protein 852095 84590849 An04g03370 Aspergillus niger hypothetical protein XP_059600486.1 849386 R 5061 CDS An04g03380 4990744 join(852220..852297,852525..852660,852799..853044,853101..853118,853174..853290,853355..853674) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein My005 - Homo sapiens; uncharacterized protein 853674 4990744 An04g03380 Aspergillus niger uncharacterized protein XP_001401706.1 852220 D 5061 CDS An04g03400 4990745 join(854671..854798,854855..855054,855114..856294) VI 1 NT_166539.1 Catalytic activity: Aldehyde + NAD+ + H2O = Carboxylate + NADH.; Localization: different aldh isozymes are located in the mitochondria and cytoplasm.; Title: strong similarity to aldehyde dehydrogenase aldA - Aspergillus niger; See PMID 2606357; See PMID 1644309; uncharacterized protein 856294 4990745 An04g03400 Aspergillus niger uncharacterized protein XP_001401707.3 854671 D 5061 CDS An04g03410 84590850 complement(join(856911..856942,857089..857309,857433..857456,857561..857585,857620..857695)) VI 1 NT_166539.1 hypothetical protein 857695 84590850 An04g03410 Aspergillus niger hypothetical protein XP_059600487.1 856911 R 5061 CDS An04g03420 4990747 join(862131..862169,862263..862423,862521..862667,862739..863336) VI 1 NT_166539.1 Function: regucalcin from R. norvegicus has an inhibitory effect on the activation of Ca2+/calmodulin-dependent enzymes and protein kinaseC and regulates nuclear function in liver cells; it can inhibit Ca(2+)-activated DNA fragmentation, DNA and RNA synthesis,protein kinase and protein phosphatase activities in the nuclei.; Function: regucalcin from R. norvegicus is a calcium-binding protein that does not contain the EF-hand motif, it is a regulatory protein in Ca2+ signaling,maintaining intracellular Ca2+ homeostasis due to activating Ca2+ pump enzymes in the plasma membrane and microsomal membranes of liver and kidney cells.; Title: strong similarity to regucalcin also known as senescence marker protein-30 SMP30 - Rattus norvegicus; See PMID 8348951; See PMID 9792046; See PMID 1420310; See PMID 10809175; See PMID 1581340; uncharacterized protein 863336 4990747 An04g03420 Aspergillus niger uncharacterized protein XP_001401709.1 862131 D 5061 CDS An04g03430 84590851 complement(join(867107..867213,867278..867404,867505..867570,867834..867967,868050..868477,868818..868979,869209..869329,869519..869563,869662..869723,869810..869889)) VI 1 NT_166539.1 hypothetical protein 869889 84590851 An04g03430 Aspergillus niger hypothetical protein XP_059600488.1 867107 R 5061 CDS An04g03440 4990749 871920..873410 VI 1 NT_166539.1 Remark: the blastp hits are due to the serine-rich ORF sequence.; Similarity: the ORF shows strong similarity to the A. niger EST an_3444.; Title: similarity to novel polypeptide sequence SEQ ID NO:1786 from patent WO2003029271-A2 - Homo sapiens; uncharacterized protein 873410 4990749 An04g03440 Aspergillus niger uncharacterized protein XP_001401711.1 871920 D 5061 CDS An04g03450 84590852 complement(join(874165..874356,874435..874539,874594..874623)) VI 1 NT_166539.1 hypothetical protein 874623 84590852 An04g03450 Aspergillus niger hypothetical protein XP_059600489.1 874165 R 5061 CDS An04g03460 4990751 join(874663..874706,874818..876177) VI 1 NT_166539.1 Catalytic activity: 3-phytase catalyzes the conversion of myo-inositol hexakisphosphate + H2O = D-myo-inositol 1,2,4,5,6-pentakisphosphate + orthophosphate.; Function: catalyzes the hydrolysis of phytic acid into myo-inositol and inorganic phosphate.; Gene-ID: phyA; Pathway: inositol phosphate metabolism.; extracellular/secretion proteins; See PMID 8865587; See PMID 9349716; See PMID 10087168; See PMID 10223979; See PMID 10328821; phytase phyA-Aspergillus niger 876177 phyA 4990751 phyA Aspergillus niger phytase phyA-Aspergillus niger XP_001401713.3 874663 D 5061 CDS An04g03470 84590853 complement(join(876510..876666,876886..877010)) VI 1 NT_166539.1 hypothetical protein 877010 84590853 An04g03470 Aspergillus niger hypothetical protein XP_059600490.1 876510 R 5061 CDS An04g03480 84590854 complement(join(877424..877435,877687..877832,878216..878344,878468..878567)) VI 1 NT_166539.1 hypothetical protein 878567 84590854 An04g03480 Aspergillus niger hypothetical protein XP_059600491.1 877424 R 5061 CDS An04g03490 4990754 complement(join(878693..881413,881475..881564)) VI 1 NT_166539.1 Title: similarity to hypothetical protein AAN10358.2 - Drosophila melanogaster; uncharacterized protein 881564 4990754 An04g03490 Aspergillus niger uncharacterized protein XP_059600492.1 878693 R 5061 CDS An04g03495 4990755 join(882513..882658,882734..882932,882996..883274,883327..883566) VI 1 NT_166539.1 Complex: Swp1 from S. cerevisiae is a component of the oligosaccharyltransferase complex.; Function: Swp1 from S. cerevisiae interacts physically with Wbp1.; Function: Swp1 from S. cerevisiae was isolated as a suppressor of a mutation in wbp1, an essential component of the N-oligosaccharyl transferase.; Title: similarity to oligosaccharyltransferase delta subunit Swp1 - Saccharomyces cerevisiae; See PMID 8175708; See PMID 8428586; uncharacterized protein 883566 4990755 An04g03495 Aspergillus niger uncharacterized protein XP_059600493.1 882513 D 5061 CDS An04g03500 4990756 join(884001..884226,884296..884663,884865..884999) VI 1 NT_166539.1 Title: weak similarity to glycoprotein gpv -Varicella-zoster virus; uncharacterized protein 884999 4990756 An04g03500 Aspergillus niger uncharacterized protein XP_001401718.3 884001 D 5061 CDS An04g03520 84590855 join(885806..886068,886345..886456,887244..887417) VI 1 NT_166539.1 Title: questionable ORF; uncharacterized protein 887417 84590855 An04g03520 Aspergillus niger uncharacterized protein XP_059600494.1 885806 D 5061 CDS An04g03530 4990759 complement(join(887989..888300,888405..888743,888799..889017)) VI 1 NT_166539.1 Function: NAD-dependent D-arabinitol dehydrogenase ARD of C. tropicalis interconverts D-arabinitol plus NAD with D-ribulose plus NADH.; Similarity: shows strong similarity to several short chain dehydrogenase/reductases with different specificities.; Title: strong similarity to NAD-dependent D-arabinitol dehydrogenase ard - Candida tropicalis; See PMID 7698655; uncharacterized protein 889017 4990759 An04g03530 Aspergillus niger uncharacterized protein XP_001401720.1 887989 R 5061 CDS An04g03540 84590856 join(889223..889341,889554..889640,889755..890202) VI 1 NT_166539.1 hypothetical protein 890202 84590856 An04g03540 Aspergillus niger hypothetical protein XP_059600495.1 889223 D 5061 CDS An04g03550 84590857 complement(join(890223..890268,890365..890414,890744..891049)) VI 1 NT_166539.1 hypothetical protein 891049 84590857 An04g03550 Aspergillus niger hypothetical protein XP_059600496.1 890223 R 5061 CDS An04g03560 84590858 join(891215..891301,891446..891564,891604..891737,891879..891903,892035..892131) VI 1 NT_166539.1 hypothetical protein 892131 84590858 An04g03560 Aspergillus niger hypothetical protein XP_059600497.1 891215 D 5061 CDS An04g03570 4990763 complement(join(893024..893486,893542..893947,894021..894147)) VI 1 NT_166539.1 Function: pyridoxine 4-dehydrogenase PLR of S. pombe catalyzes the reduction of pyridoxal by NADPH to form pyridoxine and NADP+.; Title: strong similarity to pyridoxine 4-dehydrogenase PLR - Schizosaccharomyces pombe; See PMID 10438489; uncharacterized protein 894147 4990763 An04g03570 Aspergillus niger uncharacterized protein XP_001401724.1 893024 R 5061 CDS An04g03580 4990764 join(894828..894833,895062..895943) VI 1 NT_166539.1 Title: similarity to hypothetical protein BAA97223.1 - Arabidopsis thaliana; uncharacterized protein 895943 4990764 An04g03580 Aspergillus niger uncharacterized protein XP_059600498.1 894828 D 5061 CDS An04g03590 4990765 join(896863..896908,896994..897657,897709..898900) VI 1 NT_166539.1 Catalytic activity: lysophospholipase catalyzes the conversion of 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.; Pathway: phospholipid degradation.; Title: strong similarity to lysophospholipase from patent WO0127251 - Aspergillus oryzae; uncharacterized protein 898900 4990765 An04g03590 Aspergillus niger uncharacterized protein XP_059600499.1 896863 D 5061 CDS An04g03600 4990766 join(899422..904169,904219..904771) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein EAA64794.1 - Aspergillus nidulans; uncharacterized protein 904771 4990766 An04g03600 Aspergillus niger uncharacterized protein XP_001401727.1 899422 D 5061 CDS An04g03610 4990767 complement(join(904916..904955,905062..905567)) VI 1 NT_166539.1 hypothetical protein 905567 4990767 An04g03610 Aspergillus niger hypothetical protein XP_059600500.1 904916 R 5061 CDS An04g03620 4990768 join(906068..906095,906163..906272,906327..906390,906456..906548,906597..906648,906702..907746) VI 1 NT_166539.1 Catalytic activity: 2-dehydro-3-deoxyphosphoheptonate aldolase catalyzes the conversion of 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + orthophosphate = phosphoenolpyruvate + D-erythrose 4-phosphate + H2O.; Pathway: 2-dehydro-3-deoxyphosphoheptonate aldolase catalyzes the first step in the biosynthesis from chorismate of the aromatic amino acids (the shikimate pathway).; Title: similarity to 2-dehydro-3-deoxyphosphoheptonate aldolase - Arabidopsis thaliana; uncharacterized protein 907746 4990768 An04g03620 Aspergillus niger uncharacterized protein XP_001401729.1 906068 D 5061 CDS An04g03630 4990769 complement(join(907981..908074,908150..909063,909134..909380,909448..910151)) VI 1 NT_166539.1 Title: strong similarity to hypothetical transport protein YCR023c - Saccharomyces cerevisiae; uncharacterized protein 910151 4990769 An04g03630 Aspergillus niger uncharacterized protein XP_001401730.3 907981 R 5061 CDS An04g03640 4990770 complement(join(911245..912297,912349..913058,913112..914315)) VI 1 NT_166539.1 Similarity: the ORF shows weak (but specific) similarity to the A. niger protein An17g02290. The similarity between the two proteins, however, is restricted to a stretch of about 140 amino acids.; Title: weak similarity to hypothetical protein SPAC4H3.11c - Schizosaccharomyces pombe; uncharacterized protein 914315 4990770 An04g03640 Aspergillus niger uncharacterized protein XP_001401731.1 911245 R 5061 CDS An04g03650 4990771 complement(join(915318..916610,916674..916832)) VI 1 NT_166539.1 Remark: blast matches are due to repetitive sequence.; hypothetical protein 916832 4990771 An04g03650 Aspergillus niger hypothetical protein XP_001401732.1 915318 R 5061 CDS An04g03660 84590859 join(917180..917293,917470..917664,917749..917808,917874..918011) VI 1 NT_166539.1 Title: weak similarity to hypothetical protein YLR094c - Saccharomyces cerevisiae; uncharacterized protein 918011 84590859 An04g03660 Aspergillus niger uncharacterized protein XP_059600501.1 917180 D 5061 CDS An04g03670 84590860 complement(join(918013..918067,918146..918244,918291..918412,918640..918820,918931..919044,919412..919526,919720..919780,919806..919871)) VI 1 NT_166539.1 hypothetical protein 919871 84590860 An04g03670 Aspergillus niger hypothetical protein XP_059600502.1 918013 R 5061 CDS An04g03680 4990774 join(919960..920203,920313..920394,920453..920972) VI 1 NT_166539.1 Title: similarity to glucanase ZmGnsN4 from patent WO200073470-A2 - Zea mays; uncharacterized protein 920972 4990774 An04g03680 Aspergillus niger uncharacterized protein XP_001401735.1 919960 D 5061 CDS An04g03690 4990775 complement(join(921026..921924,921978..922972,923096..924039,924105..924768,924818..925254)) VI 1 NT_166539.1 Function: the S. cerevisiae homolog Ste6p is a ABC-transporter similar to the human MDR transporter. Ste6p is responsible for transport of mating pheromone a-factor across the plasma membrane.; Induction: expression of STE6 is mating type dependent.; Similarity: shows strong similarity to several known and hypothetical ABC-type transporter proteins.; Title: strong similarity to mating pheromone transporter Ste6 - Saccharomyces cerevisiae; plasma membrane; See PMID 11294906; uncharacterized protein 925254 4990775 An04g03690 Aspergillus niger uncharacterized protein XP_059600503.1 921026 R 5061 CDS An04g03700 4990776 complement(join(925920..925977,926036..926072,926135..926419,926473..926497,926565..926609)) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein YPL225w - Saccharomyces cerevisiae; uncharacterized protein 926609 4990776 An04g03700 Aspergillus niger uncharacterized protein XP_001401737.1 925920 R 5061 CDS An04g03710 4990777 complement(join(927280..927379,927433..928277,928334..928453,928506..928741,928800..928874,928924..928951)) VI 1 NT_166539.1 Title: similarity to hypothetical protein SPBC3E7.03c - Schizosaccharomyces pombe; uncharacterized protein 928951 4990777 An04g03710 Aspergillus niger uncharacterized protein XP_001401738.1 927280 R 5061 CDS An04g03720 4990778 join(929851..932781,932831..933097,933147..935246) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein SPAC6F6.17 - Schizosaccharomyces pombe; uncharacterized protein 935246 4990778 An04g03720 Aspergillus niger uncharacterized protein XP_001401739.1 929851 D 5061 CDS An04g03730 84590861 complement(join(935421..935538,935678..935688)) VI 1 NT_166539.1 hypothetical protein 935688 84590861 An04g03730 Aspergillus niger hypothetical protein XP_059600504.1 935421 R 5061 CDS An04g03740 84590862 join(936126..936202,936293..936716,936818..936895) VI 1 NT_166539.1 Title: weak similarity to ORF1557 polypeptide sequence SEQ ID NO:3114 from patent WO200058473-A2 - Homo sapiens; uncharacterized protein 936895 84590862 An04g03740 Aspergillus niger uncharacterized protein XP_059600505.1 936126 D 5061 CDS An04g03750 4990781 complement(join(937142..937528,937581..937910,938022..938267)) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein YMR099c - Saccharomyces cerevisiae; uncharacterized protein 938267 4990781 An04g03750 Aspergillus niger uncharacterized protein XP_001401742.1 937142 R 5061 CDS An04g03770 4990783 complement(join(940374..940417,940649..941129,941183..941702,941752..941952,942011..942096,942146..942376)) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein AAD34558.1 - Aspergillus terreus; uncharacterized protein 942376 4990783 An04g03770 Aspergillus niger uncharacterized protein XP_059600506.1 940374 R 5061 CDS An04g03780 4990784 complement(join(942838..944872,944971..945029)) VI 1 NT_166539.1 Title: strong similarity to hypothetical membrane protein YJL057c - Saccharomyces cerevisiae; uncharacterized protein 945029 4990784 An04g03780 Aspergillus niger uncharacterized protein XP_001401744.1 942838 R 5061 CDS An04g03790 4990785 complement(join(945705..946541,946974..947721,947777..947874)) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein YNR053c - Saccharomyces cerevisiae; uncharacterized protein 947874 4990785 An04g03790 Aspergillus niger uncharacterized protein XP_001401745.1 945705 R 5061 CDS An04g03800 4990786 948256..949119 VI 1 NT_166539.1 Title: weak similarity to hypothetical protein CAB51071.1 - Homo sapiens; uncharacterized protein 949119 4990786 An04g03800 Aspergillus niger uncharacterized protein XP_001401746.1 948256 D 5061 CDS An04g03810 4990787 complement(join(949413..950280,950336..950576,950624..950669)) VI 1 NT_166539.1 Complex: TFB3 of S. cerevisiae is a subunit of the RNA polymerase II basal transcription factor TFIIH complex,that is composed also by the subunits TFB1, TFB2, TFB4,KIN28, RAD3, SSL1, SSL2, and CCL1.; Function: TFIIH is essential for transcription by RNA polymerase II and nucleotide excision DNA repair.; Title: strong similarity to subunit of transcription initiation factor TFIIH Tfb3 - Saccharomyces cerevisiae; nucleus; See PMID 9774652; See PMID 10373527; See PMID 11007479; uncharacterized protein 950669 4990787 An04g03810 Aspergillus niger uncharacterized protein XP_001401747.1 949413 R 5061 CDS An04g03820 4990788 join(950959..952763,952844..952931) VI 1 NT_166539.1 Remark: The lamprey is considered the most primitive living vertebrate and its neurofilaments (NFs) are unique in being homopolymers of a single 180 kDa subunit (NF-180); Title: weak similarity to NF-180 - Petromyzon marinus; uncharacterized protein 952931 4990788 An04g03820 Aspergillus niger uncharacterized protein XP_059600507.1 950959 D 5061 CDS An04g03830 4990789 join(956540..956768,956826..958155,958207..958234) VI 1 NT_166539.1 Title: similarity to phorbol activated nuclear factor-like protein PNF1 from patent WO200162790-A2 - Homo sapiens; uncharacterized protein 958234 4990789 An04g03830 Aspergillus niger uncharacterized protein XP_059600508.1 956540 D 5061 CDS An04g03840 4990790 complement(959653..960954) VI 1 NT_166539.1 Title: similarity to microtubule binding protein D-CLIP-190 - Drosophila melanogaster; cytoskeleton; uncharacterized protein 960954 4990790 An04g03840 Aspergillus niger uncharacterized protein XP_001401750.1 959653 R 5061 CDS An04g03850 4990791 complement(join(961807..963942,963999..965951,966008..966580)) VI 1 NT_166539.1 Title: strong similarity to hypothetical beta transducin-like protein het-e1 - Podospora anserina; uncharacterized protein 966580 4990791 An04g03850 Aspergillus niger uncharacterized protein XP_059600509.1 961807 R 5061 CDS An04g03860 4990792 967959..968711 VI 1 NT_166539.1 Catalytic activity: R-CHOH-R' + NADP(+) <=> R-CO-R' + NADPH; Function: Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes,daunorubicin, and prostaglandins E and F, reducing them to the corresponding alcohol.; Title: similarity to carbonyl reductase NADPH -Rattus norvegicus; uncharacterized protein 968711 4990792 An04g03860 Aspergillus niger uncharacterized protein XP_001401752.1 967959 D 5061 CDS An04g03870 4990793 join(970457..970622,970732..971462) VI 1 NT_166539.1 Similarity: the ORF shows similarity to the A. niger protein An11g05330. The similarity between the two proteins, however, is restricted to a stretch of about 100 amino acids.; Title: weak similarity to phosphatidic acid phosphatase ATPAP2 from patent WO200005385-A1 - Arabidopsis thaliana; uncharacterized protein 971462 4990793 An04g03870 Aspergillus niger uncharacterized protein XP_059600510.1 970457 D 5061 CDS An04g03880 4990794 972746..973132 VI 1 NT_166539.1 hypothetical protein 973132 4990794 An04g03880 Aspergillus niger hypothetical protein XP_001401754.3 972746 D 5061 CDS An04g03890 4990795 join(974265..974340,974421..976816) VI 1 NT_166539.1 Function: HxB is responsible for the insertion of the terminal sulphur atom in the molybdopterin cofactor.; Induction: HxB is independently controlled by the purine utilization and the nicotinate utilization transcriptional activating systems.; Remark: the xanthine oxidase class of molybdoenzymes requires the molybdopterin cofactor (MoCF) to have a terminal, cyanolysable sulphur ligand.; Title: strong similarity to transulphurylase hxB -Aspergillus nidulans; See PMID 10096075; See PMID 11029694; uncharacterized protein 976816 4990795 An04g03890 Aspergillus niger uncharacterized protein XP_001401755.1 974265 D 5061 CDS An04g03900 4990796 complement(join(977091..977597,977636..977749)) VI 1 NT_166539.1 Remark: alternate names in S. cerevisiae = YmL25,YGR076c.; Title: similarity to mitochondrial ribosomal protein of the large subunit Ymr26 - Saccharomyces cerevisiae; localisation:mitochondrion; mitochondrial 54S ribosomal protein mL59 977749 4990796 An04g03900 Aspergillus niger mitochondrial 54S ribosomal protein mL59 XP_059600511.1 977091 R 5061 CDS An04g03910 4990797 join(978455..978523,978606..978821,978889..978992,979506..980870,981034..981055) VI 1 NT_166539.1 Complex: Prp39p is uniquely associated with the U1 snRNP and is recruited with the U1 snRNP into splicing complexes.; Function: Prp39p is necessary for the stable interaction of mRNA precursors with the snRNP components of the pre-mRNA splicing machinery.; Title: strong similarity to pre-mRNA splicing factor Prp39 - Saccharomyces cerevisiae; nucleus; See PMID 8196608; uncharacterized protein 981055 4990797 An04g03910 Aspergillus niger uncharacterized protein XP_001401757.3 978455 D 5061 CDS An04g03920 4990798 join(981396..981695,981760..983738,983829..983982) VI 1 NT_166539.1 Complex: U5-100kD is tightly associated with the U5 snRNP.; Function: U5-100kD is an RS domain-containing putative RNA helicase.; Function: U5-100kD potentially facilitates conformational changes in the spliceosome during nuclear pre-mRNA splicing.; Similarity: the C-terminal domain of U5-100kD shows significant homology to the S. cerevisiae splicing factor Prp28p.; Title: strong similarity to U5 snRNP 100 kD protein U5-100kD - Homo sapiens; nucleus; See PMID 9409622; uncharacterized protein 983982 4990798 An04g03920 Aspergillus niger uncharacterized protein XP_001401758.1 981396 D 5061 CDS An04g03930 4990799 complement(join(984334..984456,984533..986903,986991..987142)) VI 1 NT_166539.1 Function: the aminopeptidase apsA from A. niger was found to be active towards a number of amino acid p-nitroanilide (pNA) substrates, viz. K-pNA, R-pNA, L-pNA,M-pNA, A-pNA and F-pNA.; Gene-ID: apsA; Remark: the most preferred N-terminal amino acid is lysine and not leucine,arginine or alanine, the N-terminal amino acids preferred by the yeast homologues.; See PMID 11495983; lysine aminopeptidase apsA-Aspergillus niger 987142 apsA 4990799 apsA Aspergillus niger lysine aminopeptidase apsA-Aspergillus niger XP_001401759.1 984334 R 5061 CDS An04g03940 4990800 complement(join(988492..989090,989160..989424,989484..989934,989994..990225,990316..990418)) VI 1 NT_166539.1 Function: MUP1 encodes the high affinity methionine permease from S. cerevisiae.; Function: MUP1 has also be shown to be a major permease in cysteine uptake.; Remark: MUP1 encodes an integral membrane protein with 13 putative membrane-spanning regions.; Title: strong similarity to high affinity methionine permease Mup1 - Saccharomyces cerevisiae; plasma membrane; See PMID 8893857; See PMID 11330701; uncharacterized protein 990418 4990800 An04g03940 Aspergillus niger uncharacterized protein XP_001401760.1 988492 R 5061 CDS An04g03950 4990801 complement(join(991847..992139,992178..994758,994887..994992,995082..995125)) VI 1 NT_166539.1 Function: APG1 is a serine/threonine protein kinase involved in induction of autophagy after nutrient limitation.; Remark: S. cerevisiae imports cytosolic components into the vacuole non-selectively by autophagy and degrades them by vacuolar hydrolases under nutrient starvation conditions.; Remark: at least 15 APG genes are involved in autophagy in yeast.; Title: strong similarity to serine/threonine protein kinase Apg1 - Saccharomyces cerevisiae; See PMID 8224160; See PMID 9224897; uncharacterized protein 995125 4990801 An04g03950 Aspergillus niger uncharacterized protein XP_059600512.1 991847 R 5061 CDS An04g03960 4990802 complement(join(997590..999682,999747..1000299)) VI 1 NT_166539.1 Catalytic activity: SEC59 catalyzes the transfer of mannose to dolichol-linked oligosaccharide.; Function: SEC59 encodes a membrane protein required for core glycosylation in S. cerevisiae.; Phenotype: SEC59 mutants accumulate inactive and incompletely glycosylated forms of secretory proteins.; Title: similarity to dolichol kinase Sec59 -Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 2657387; See PMID 1323123; uncharacterized protein 1000299 4990802 An04g03960 Aspergillus niger uncharacterized protein XP_001401762.1 997590 R 5061 CDS An04g03970 4990803 complement(1000821..1003175) VI 1 NT_166539.1 Remark: The EST sequence of EMBLEST:BE759313 is from Aspergillus niger but deviates in several positions from the sequence of the genomic DNA.; Title: strong similarity to hypothetical protein SPAC577.12 - Schizosaccharomyces pombe; uncharacterized protein 1003175 4990803 An04g03970 Aspergillus niger uncharacterized protein XP_001401763.1 1000821 R 5061 CDS An04g03980 4990804 complement(join(1004462..1005726,1005863..1006436)) VI 1 NT_166539.1 Function: MHY1 encodes a C(2)H(2)-type zinc finger protein with the ability to bind putative stress response elements and whose activity is essential for both hyphal and pseudohyphal growth in Y. lipolytica.; Function: Mhy1p may act as a transcription factor.; Induction: transcription of MHY1 is dramatically increased during the yeast-to-hypha transition in Yarrowia lipolytica.; Phenotype: Deletion of MHY1 is viable and has no effect on mating, but it does result in a complete inability of cells to undergo mycelial growth.; Title: similarity to C2H2-type zinc finger protein Mhy1p - Yarrowia lipolytica; nucleus; See PMID 10322005; uncharacterized protein 1006436 4990804 An04g03980 Aspergillus niger uncharacterized protein XP_001401764.1 1004462 R 5061 CDS An04g03990 84590863 join(1006663..1006709,1006801..1006955,1007157..1007263) VI 1 NT_166539.1 hypothetical protein 1007263 84590863 An04g03990 Aspergillus niger hypothetical protein XP_059600513.1 1006663 D 5061 CDS An04g04000 84590864 complement(join(1007734..1007845,1008138..1008236,1008306..1008406,1008455..1008521,1008788..1008895,1009018..1009093,1009286..1009337)) VI 1 NT_166539.1 Title: strong similarity to EST an_2710 -Aspergillus niger; uncharacterized protein 1009337 84590864 An04g04000 Aspergillus niger uncharacterized protein XP_059600514.1 1007734 R 5061 CDS An04g04010 84590865 join(1015056..1015268,1015330..1015473,1016111..1016602) VI 1 NT_166539.1 hypothetical protein 1016602 84590865 An04g04010 Aspergillus niger hypothetical protein XP_059600515.1 1015056 D 5061 CDS An04g04020 84590866 complement(join(1016799..1017083,1017154..1017276)) VI 1 NT_166539.1 hypothetical protein 1017276 84590866 An04g04020 Aspergillus niger hypothetical protein XP_059600516.1 1016799 R 5061 CDS An04g04030 84590867 join(1017287..1017414,1017507..1017636,1018053..1018110,1018229..1018408,1018476..1018642,1018695..1018804,1018854..1018944) VI 1 NT_166539.1 hypothetical protein 1018944 84590867 An04g04030 Aspergillus niger hypothetical protein XP_059600517.1 1017287 D 5061 CDS An04g04035 84590868 1019861..1020070 VI 1 NT_166539.1 hypothetical protein 1020070 84590868 An04g04035 Aspergillus niger hypothetical protein XP_059600518.1 1019861 D 5061 CDS An04g04040 4990811 complement(join(1020361..1020437,1020521..1021284,1021357..1021504,1021640..1021718)) VI 1 NT_166539.1 Title: strong similarity to hypothetical thioredoxin SPAC577.08c - Schizosaccharomyces pombe; uncharacterized protein 1021718 4990811 An04g04040 Aspergillus niger uncharacterized protein XP_001401771.3 1020361 R 5061 CDS An04g04050 4990812 complement(1022445..1023029) VI 1 NT_166539.1 Title: similarity to hypothetical protein dnajp -Schizosaccharomyces pombe; uncharacterized protein 1023029 4990812 An04g04050 Aspergillus niger uncharacterized protein XP_001401772.1 1022445 R 5061 CDS An04g04060 4990813 complement(join(1023760..1024497,1024570..1024926)) VI 1 NT_166539.1 Catalytic activity: 2 ferrocytochrome c + H(2)O(2) <=> 2 ferricytochrome c + 2 H(2)O.; Cofactor: heme; Function: protection against toxic peroxides.; Title: strong similarity to cytochrome-c peroxidase precursor Ccp1 - Saccharomyces cerevisiae; uncharacterized protein 1024926 4990813 An04g04060 Aspergillus niger uncharacterized protein XP_001401773.1 1023760 R 5061 CDS An04g04070 4990814 complement(join(1025226..1025343,1025491..1025643,1025912..1026095,1026366..1026493,1027158..1027716,1027982..1028135)) VI 1 NT_166539.1 Similarity: the ORF shows weak similarity to anohter A. niger protein: An11g09200. The similarity between the two proteins, however, is restricted to a stretch of about 60 amino acids.; Title: weak similarity to hypothetical protein encoded by An11g09200 - Aspergillus niger; uncharacterized protein 1028135 4990814 An04g04070 Aspergillus niger uncharacterized protein XP_059600519.1 1025226 R 5061 CDS An04g04080 4990815 join(1028770..1028820,1028920..1029492,1029545..1029688,1029741..1030580) VI 1 NT_166539.1 Title: similarity to hypothetical negative acting factor related protein - Neurospora crassa; uncharacterized protein 1030580 4990815 An04g04080 Aspergillus niger uncharacterized protein XP_059600520.1 1028770 D 5061 CDS An04g04090 84590869 complement(join(1030983..1031145,1031229..1031342,1031418..1031533,1031742..1031982,1032072..1032079)) VI 1 NT_166539.1 hypothetical protein 1032079 84590869 An04g04090 Aspergillus niger hypothetical protein XP_059600521.1 1030983 R 5061 CDS An04g04100 4990817 join(1032100..1032214,1032282..1032302,1032393..1032499,1032573..1032741,1032901..1034447) VI 1 NT_166539.1 Function: GTS1 gene product of S. cerevisiae appears to modulate the timing of budding to obtain an appropriate cell size independent of the DNA replication cycle. a loss-of-function mutation results in a shortened unbudded period and smaller cell size, whereas overexpression of the GTS1 gene product extends the unbudded period and results in larger cells.; Title: strong similarity to Lsr1 - Saccharomyces cerevisiae; See PMID 8035831; See PMID 9046087; See PMID 9219336; uncharacterized protein 1034447 4990817 An04g04100 Aspergillus niger uncharacterized protein XP_059600522.1 1032100 D 5061 CDS An04g04110 4990818 complement(join(1035154..1036516,1036577..1036723,1036888..1037000,1037058..1037288,1037429..1037809)) VI 1 NT_166539.1 Title: strong similarity to protein PIG-B - Mus musculus; See PMID 8861954; uncharacterized protein 1037809 4990818 An04g04110 Aspergillus niger uncharacterized protein XP_059600523.1 1035154 R 5061 CDS An04g04120 84590870 complement(join(1038454..1038559,1038652..1038734)) VI 1 NT_166539.1 hypothetical protein 1038734 84590870 An04g04120 Aspergillus niger hypothetical protein XP_059600524.1 1038454 R 5061 CDS An04g04130 4990820 join(1038787..1039278,1039349..1040050,1040105..1040290) VI 1 NT_166539.1 Catalytic activity: L-ornithine + a 2-oxo acid <=> L-glutamate 5-semialdehyde + an L-amino acid.; Cofactor: Pyridoxal-phosphate.; Title: strong similarity to ornithine-2-oxo-acid transaminase YLR438w - Saccharomyces cerevisiae; uncharacterized protein 1040290 4990820 An04g04130 Aspergillus niger uncharacterized protein XP_001401780.1 1038787 D 5061 CDS An04g04140 84590871 complement(join(1040389..1040559,1040700..1040846)) VI 1 NT_166539.1 hypothetical protein 1040846 84590871 An04g04140 Aspergillus niger hypothetical protein XP_059600525.1 1040389 R 5061 CDS An04g04150 4990822 complement(join(1041471..1041682,1041775..1041921,1042002..1042481,1042558..1042753,1042816..1042998)) VI 1 NT_166539.1 Remark: Hereditary tyrosinemia type 1 (HT1) is an autosomal recessive disease caused by a deficiency of the enzyme involved in the last step of tyrosine degradation,fumarylacetoacetate hydrolase (FAH). Thus far, 34 mutations in the FAH gene have been reported in various HT1 patients.; Title: strong similarity to fumarylacetoacetase -Homo sapiens; See PMID 10508789; See PMID 11154690; See PMID 11209059; See PMID 11262262; See PMID 11278491; uncharacterized protein 1042998 4990822 An04g04150 Aspergillus niger uncharacterized protein XP_059600526.1 1041471 R 5061 CDS An04g04160 84590872 join(1043419..1043523,1043570..1043716,1043763..1044296,1044430..1045119) VI 1 NT_166539.1 Phenotype: mutations in S. cerevisiae Hol I are resposible for nonselective cation/histindiol uptake in S. cerevisiae.; Remark: Hol I is a member of the major facilitator superfamily (drug resistance subfamily) of transporters.; Title: similarity to multidrug resistance protein Hol1 - Saccharomyces cerevisiae; See PMID 8955402; uncharacterized protein 1045119 84590872 An04g04160 Aspergillus niger uncharacterized protein XP_059600527.1 1043419 D 5061 CDS An04g04170 4990824 complement(join(1045499..1045819,1045872..1046197,1046265..1046375,1046423..1046558)) VI 1 NT_166539.1 Catalytic activity: D-arabinitol + NAD(+) <=> D-ribulose + NADH.; Title: strong similarity to NAD-dependent D-arabinitol dehydrogenase ard - Candida tropicalis; uncharacterized protein 1046558 4990824 An04g04170 Aspergillus niger uncharacterized protein XP_059600528.1 1045499 R 5061 CDS An04g04180 84590873 complement(join(1047435..1047932,1047999..1048112,1048144..1048155)) VI 1 NT_166539.1 hypothetical protein 1048155 84590873 An04g04180 Aspergillus niger hypothetical protein XP_059600529.1 1047435 R 5061 CDS An04g04190 84590874 join(1048664..1048750,1048978..1049100,1049191..1049244,1049365..1049424,1049557..1049793) VI 1 NT_166539.1 hypothetical protein 1049793 84590874 An04g04190 Aspergillus niger hypothetical protein XP_059600530.1 1048664 D 5061 CDS An04g04200 84590875 complement(join(1050149..1050278,1050373..1050591,1050930..1051061,1051147..1051324,1051407..1051498,1051549..1051908,1052340..1052420,1052514..1052540,1052734..1052827,1052911..1053028)) VI 1 NT_166539.1 hypothetical protein 1053028 84590875 An04g04200 Aspergillus niger hypothetical protein XP_059600531.1 1050149 R 5061 CDS An04g04210 4990828 1053584..1054747 VI 1 NT_166539.1 Catalytic activity: S-adenosyl-L-methionine + 5-alpha-cholest-8,24-dien-3-beta-ol <=> S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.; Cofactor: Glutathione.; Title: strong similarity to S-adenosyl-L-methionine:delta24-sterol-C-methyltransferase - Glycine max; uncharacterized protein 1054747 4990828 An04g04210 Aspergillus niger uncharacterized protein XP_001401788.1 1053584 D 5061 CDS An04g04220 84590876 complement(join(1055001..1055147,1055225..1055350,1055441..1055537,1055636..1055727)) VI 1 NT_166539.1 hypothetical protein 1055727 84590876 An04g04220 Aspergillus niger hypothetical protein XP_059600532.1 1055001 R 5061 CDS An04g04230 4990830 join(1056428..1056669,1056725..1056858,1056938..1057069,1057125..1057451,1057616..1057782) VI 1 NT_166539.1 hypothetical protein 1057782 4990830 An04g04230 Aspergillus niger hypothetical protein XP_059600533.1 1056428 D 5061 CDS An04g04240 4990831 join(1058446..1058508,1058574..1059918,1059979..1060367) VI 1 NT_166539.1 Title: strong similarity to phosphate transport protein GvPT - Glomus versiforme; uncharacterized protein 1060367 4990831 An04g04240 Aspergillus niger uncharacterized protein XP_001401791.1 1058446 D 5061 CDS An04g04260 84590877 join(1061351..1061575,1061738..1061781,1061892..1062033) VI 1 NT_166539.1 hypothetical protein 1062033 84590877 An04g04260 Aspergillus niger hypothetical protein XP_059600534.1 1061351 D 5061 CDS An04g04270 4990834 join(1062906..1063515,1063568..1064805) VI 1 NT_166539.1 Title: similarity to hypothetical protein mlr1435 -Mesorhizobium loti; uncharacterized protein 1064805 4990834 An04g04270 Aspergillus niger uncharacterized protein XP_001401793.1 1062906 D 5061 CDS An04g04280 4990835 join(1068316..1068394,1068453..1068919) VI 1 NT_166539.1 Remark: there is homology to a 5' EST an_3603 from A. niger.; Title: similarity to hypothetical protein SPBC800.14c - Schizosaccharomyces pombe; uncharacterized protein 1068919 4990835 An04g04280 Aspergillus niger uncharacterized protein XP_001401794.1 1068316 D 5061 CDS An04g04290 84590878 join(1069138..1069370,1069889..1070195,1070257..1070523,1070907..1071183,1071222..1071622) VI 1 NT_166539.1 hypothetical protein 1071622 84590878 An04g04290 Aspergillus niger hypothetical protein XP_059600535.1 1069138 D 5061 CDS An04g04300 84590879 complement(join(1072956..1073100,1073137..1073320,1073398..1073446)) VI 1 NT_166539.1 hypothetical protein 1073446 84590879 An04g04300 Aspergillus niger hypothetical protein XP_059600536.1 1072956 R 5061 CDS An04g04310 84590880 join(1074691..1074792,1074864..1074920,1075038..1075070,1075140..1075371,1075715..1075786,1076972..1077213,1077525..1077659,1077734..1077814) VI 1 NT_166539.1 Remark: the ORF has an unusual exon/intron structure for A. niger.; hypothetical protein 1077814 84590880 An04g04310 Aspergillus niger hypothetical protein XP_059600537.1 1074691 D 5061 CDS An04g04320 4990839 join(1078659..1079159,1079232..1080987,1081053..1081564,1081630..1083081) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein encoded by An04g03250 - Aspergillus niger; uncharacterized protein 1083081 4990839 An04g04320 Aspergillus niger uncharacterized protein XP_059600538.1 1078659 D 5061 CDS An04g04330 4990840 complement(join(1084347..1084725,1084805..1085922,1085987..1086199)) VI 1 NT_166539.1 Catalytic activity: ATP + 4-coumarate + CoA = AMP + pyrophosphate + 4-coumaroyl-CoA.; Pathway: flavonoids, stilbene and lignin biosynthesis.; Remark: In soybean, 4CL isoenzymes possessing different substrate affinities for substituted cinnamic acids, and showing differential regulation to environmental stress, may play a pivotal role in distributing substituted cinnamate intermediates at a branch point of general phenylpropanoid metabolism into subsequent specific pathways.; Title: strong similarity to 4-coumarate-CoA ligase 4 4CL4 - Glycine max; See PMID 8278545; uncharacterized protein 1086199 4990840 An04g04330 Aspergillus niger uncharacterized protein XP_001401799.3 1084347 R 5061 CDS An04g04340 4990841 complement(join(1086488..1087436,1087489..1093931)) VI 1 NT_166539.1 Function: polyketide synthases catalyze the assembly of complex natural products from simple precursors such as propionyl-CoA and methylmalonyl-CoA in a biosynthetic process that closely parallels fatty acid biosynthesis.; Remark: the lovF gene encodes an enzyme that is responsible for the biosynthesis of the (2R)-2-methylbutyryl side chain of lovastatin.; Title: strong similarity to nonaketide synthase lovB - Aspergillus terreus; See PMID 10334994; See PMID 11386351; uncharacterized protein 1093931 4990841 An04g04340 Aspergillus niger uncharacterized protein XP_059600539.1 1086488 R 5061 CDS An04g04350 84590881 join(1094396..1094426,1094815..1095088,1095106..1095328) VI 1 NT_166539.1 Title: similarity to hypothetical protein encoded by prophage CP-933X Z1925 - Escherichia coli; uncharacterized protein 1095328 84590881 An04g04350 Aspergillus niger uncharacterized protein XP_059600540.1 1094396 D 5061 CDS An04g04360 84590882 join(1096041..1096296,1096364..1096815,1096863..1096937) VI 1 NT_166539.1 Title: similarity to hypothetical protein 104H10.250 - Neurospora crassa; uncharacterized protein 1096937 84590882 An04g04360 Aspergillus niger uncharacterized protein XP_059600541.1 1096041 D 5061 CDS An04g04370 4990844 join(1097425..1097564,1097626..1097732,1097795..1099659) VI 1 NT_166539.1 Catalytic activity: L-phenylalanine = trans-cinnamate + NH3.; Pathway: tyrosine metabolism; phenylalanine metabolism; nitrogen metabolism; alkaloid biosynthesis II.; Remark: the active sites of the enzyme phenylalanine ammonia-lyase (Pal) from Rhodosporidium toruloides contains a dehydroalanine residue that is believed to be essential for catalytic activity.; Similarity: belongs to the histidine ammonia-lyases.; Title: strong similarity to phenylalanine ammonia-lyase Pal - Rhodosporidium toruloides; See PMID 8200528; See PMID 1368015; See PMID 1773059; uncharacterized protein 1099659 4990844 An04g04370 Aspergillus niger uncharacterized protein XP_001401803.1 1097425 D 5061 CDS An04g04380 4990845 complement(join(1100318..1103428,1103707..1103793,1103864..1103918,1103949..1103977)) VI 1 NT_166539.1 Remark: the terminal NRPS (non-ribosomal peptide synthetases) MxaA extends the assembled polyketide chain of the myxalamids with alanine. MxaA contains an N-terminal domain with homology to NAD binding proteins, which is responsible during the biogenesis for a novel type of reductive chain release giving rise to the 2-amino-propanol moiety of the myxalamids.; Similarity: belongs to the non-ribosomal peptide synthetase modules and related proteins.; Title: strong similarity to nonribosomal peptide synthase MxaA - Stigmatella aurantiaca; See PMID 11182319; uncharacterized protein 1103977 4990845 An04g04380 Aspergillus niger uncharacterized protein XP_001401804.3 1100318 R 5061 CDS An04g04390 4990846 join(1105379..1105667,1105730..1106028) VI 1 NT_166539.1 Remark: activitie of pehA and of the eight enzymes involved in the catabolism of phthalate in Arthrobacter keyseri through protocatechuate to pyruvate and oxaloacetate were demonstrated in cells or cell extracts of recombinant E. coli strains.; Title: similarity to phthalate ester hydrolase pehA - Arthrobacter keyseri; See PMID 11371533; uncharacterized protein 1106028 4990846 An04g04390 Aspergillus niger uncharacterized protein XP_001401805.1 1105379 D 5061 CDS An04g04400 4990847 complement(1106798..1108519) VI 1 NT_166539.1 Remark: human telomeres are maintained by telomerase, a reverse transcriptase that adds telomeric repeats to chromosome ends. In human tumors and immortalized cells,telomeres are often maintained at a constant length setting, indicating that telomerase-mediated telomere elongation is tightly regulated. Tankyrase, a telomeric poly(ADP-ribose) polymerase (PARP), was identified through its interaction with TRF1, a negative regulator of telomere extension by telomerase.; Remark: similarity to Human tankyrase2 patent WO200100849-A1.; Title: similarity to tankyrase2 TANK2 from patent WO200100849-A1 - Homo sapiens; See PMID 11069113; uncharacterized protein 1108519 4990847 An04g04400 Aspergillus niger uncharacterized protein XP_001401806.1 1106798 R 5061 CDS An04g04410 84590883 complement(join(1109177..1109338,1109425..1109571)) VI 1 NT_166539.1 hypothetical protein 1109571 84590883 An04g04410 Aspergillus niger hypothetical protein XP_059600542.1 1109177 R 5061 CDS An04g04420 84590884 complement(join(1109911..1110077,1110261..1110346,1110438..1110521,1110590..1110807)) VI 1 NT_166539.1 hypothetical protein 1110807 84590884 An04g04420 Aspergillus niger hypothetical protein XP_059600543.1 1109911 R 5061 CDS An04g04430 4990850 1111092..1112816 VI 1 NT_166539.1 Catalytic activity: digallate + H2O = 2 Gallate.; Remark: tannase consisted of two kinds of subunits,linked by a disulfide bond(s) with molecular weights of about 30,000 and 33,000, respectively.; Remark: the tannase gene product is translated as a single polypeptide that is cleaved by post-translational modification into two tannase subunits linked by a disulfide bond(s).; Remark: this enzyme hydrolyzes the ester bonds of tannic acid to produce gallic acid and glucose.; Title: strong similarity to precursor of tannase -Aspergillus oryzae; See PMID 8917102; uncharacterized protein 1112816 4990850 An04g04430 Aspergillus niger uncharacterized protein XP_001401809.1 1111092 D 5061 CDS An04g04440 4990851 complement(join(1113236..1113798,1113844..1114332,1114402..1114849)) VI 1 NT_166539.1 Remark: the mcr locus from Streptomyces lavendulae confers high level resistance (> 100 micrograms/ml) to mitomycin C (MC) and related mitomycins.; Remark: the predicted ORF shows similarity to oxidoreductases with different specificity.; Title: strong similarity to mcrA - Streptomyces lavendulae; See PMID 8917108; uncharacterized protein 1114849 4990851 An04g04440 Aspergillus niger uncharacterized protein XP_059600544.1 1113236 R 5061 CDS An04g04450 84590885 complement(1116122..1116451) VI 1 NT_166539.1 hypothetical protein 1116451 84590885 An04g04450 Aspergillus niger hypothetical protein XP_059600545.1 1116122 R 5061 CDS An04g04460 4990853 join(1117099..1117213,1117273..1117451) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein CAE47852.1/AfA24A6.020c - Aspergillus fumigatus; uncharacterized protein 1117451 4990853 An04g04460 Aspergillus niger uncharacterized protein XP_001401812.1 1117099 D 5061 CDS An04g04470 4990854 join(1118216..1118627,1118707..1118966) VI 1 NT_166539.1 Remark: a splice site was detected upstream of the START codon.; Title: weak similarity to NifA-regulated gene NrgA -Bradyrhizobium japonicum; See PMID 10692350; uncharacterized protein 1118966 4990854 An04g04470 Aspergillus niger uncharacterized protein XP_001401813.1 1118216 D 5061 CDS An04g04480 4990855 complement(1119720..1120754) VI 1 NT_166539.1 Remark: LovC Aspergillus terreus interacts with lovastatin nonaketide synthase (LNKS) and is necessary for the correct processing of the growing polyketide chain and production of dihydromonacolin L.; Remark: putative part of the lovastatin biosynthesis gene cluster as seen in Aspergillus terreus.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994; uncharacterized protein 1120754 4990855 An04g04480 Aspergillus niger uncharacterized protein XP_001401814.1 1119720 R 5061 CDS An04g04490 4990856 join(1121148..1121586,1121633..1122144,1122210..1123232) VI 1 NT_166539.1 Remark: grt1(+) defines an independent pathway that facilitates the function of Slp1.; Title: strong similarity to zinc-finger protein grt1p - Schizosaccharomyces pombe; See PMID 11058086; uncharacterized protein 1123232 4990856 An04g04490 Aspergillus niger uncharacterized protein XP_059600546.1 1121148 D 5061 CDS An04g04500 4990857 join(1123692..1124674,1124738..1125557) VI 1 NT_166539.1 Remark: the human MUC3 is a large mucin glycoprotein expressed by the human intestine and gall bladder.; Similarity: the similarities of the ORF encoded protein to Muc1 from S. cerevisiae and the other proteins are mainly based on repetitive structures.; Title: similarity to ntestinal mucin MUC3 - Homo sapiens; See PMID 9334251; uncharacterized protein 1125557 4990857 An04g04500 Aspergillus niger uncharacterized protein XP_059600547.1 1123692 D 5061 CDS An04g04510 4990858 complement(join(1125670..1125944,1126017..1126770)) VI 1 NT_166539.1 Remark: The jlbA mRNA formation in A. nidulans is elevated up to 40-fold upon amino acid starvation induced by the addition of the false feedback inhibitor 3-amino-1,2, 4-triazole.; Similarity: the ORF shows strong similarity to the A. niger EST an_2580.; Title: similarity to transcription factor jlbA -Aspergillus nidulans; nucleus; See PMID 11525406; uncharacterized protein 1126770 4990858 An04g04510 Aspergillus niger uncharacterized protein XP_001401817.1 1125670 R 5061 CDS An04g04520 84590886 complement(join(1127312..1127717,1128205..1128272)) VI 1 NT_166539.1 Title: questionable ORF; uncharacterized protein 1128272 84590886 An04g04520 Aspergillus niger uncharacterized protein XP_059600548.1 1127312 R 5061 CDS An04g04530 4990860 join(1128395..1128505,1128580..1128948,1129040..1129294) VI 1 NT_166539.1 Catalytic activity: endohydrolysis of beta-1,4-linkages between N-acetyl-D-glucosamine and D-glucosamine residues in a partly acetylated chitosan.; Pathway: aminosugars metabolism.; Remark: by endo-splitting activity, the chitosanase hydrolysed chitosan to form chitosan oligomers with chitotriose, chitotetraose and chitopentaose as the major products. The enzyme hydrolyses chitohexaose to form chitotriose, while the chitopentaose and shorter oligomers remain intact.; Title: strong similarity to chitosanase csnA -Aspergillus oryzae; See PMID 11055393; See PMID 11388486; uncharacterized protein 1129294 4990860 An04g04530 Aspergillus niger uncharacterized protein XP_001401819.1 1128395 D 5061 CDS An04g04540 4990861 complement(join(1129718..1131114,1131162..1131515,1131577..1131775)) VI 1 NT_166539.1 Title: similarity to hypothetical protein YLR352w -Saccharomyces cerevisiae; uncharacterized protein 1131775 4990861 An04g04540 Aspergillus niger uncharacterized protein XP_059600549.1 1129718 R 5061 CDS An04g04550 84590887 join(1132368..1132372,1132449..1132817,1133140..1133365,1133418..1133849) VI 1 NT_166539.1 hypothetical protein 1133849 84590887 An04g04550 Aspergillus niger hypothetical protein XP_059600550.1 1132368 D 5061 CDS An04g04560 84590888 complement(join(1134462..1134551,1134605..1134718,1134774..1134860,1135109..1135245,1135426..1135542,1136084..1136149,1136242..1136415,1136514..1136624,1136752..1136830)) VI 1 NT_166539.1 hypothetical protein 1136830 84590888 An04g04560 Aspergillus niger hypothetical protein XP_059600551.1 1134462 R 5061 CDS An04g04570 4990864 1137104..1139182 VI 1 NT_166539.1 Function: co-expression of het-e and het-c lead to cell death.; Function: het-e1 of P. anserina is responsible for vegetative incompatibility.; Remark: het-e1 of P. anserina shows also two sequence motifs, a GTP-binding domain and a repeated region that shares similarity with that of the beta-transducin.; Remark: the reactivity of the HET-E protein depends on two functional elements, a GTP-binding domain and several WD40 repeats.; Title: similarity to beta transducin-like protein het-e1 - Podospora anserina; See PMID 7557402; uncharacterized protein 1139182 4990864 An04g04570 Aspergillus niger uncharacterized protein XP_001401823.1 1137104 D 5061 CDS An04g04580 84590889 complement(join(1140365..1140397,1140551..1140604,1140680..1141570)) VI 1 NT_166539.1 Similarity: the ORF shows strong similarity to the A. niger protein An11g05870. An11g05870, however, is much longer than the ORF (853 compared to 325 amino acids).; Title: strong similarity to hypothetical protein encoded by An11g05870 - Aspergillus niger; uncharacterized protein 1141570 84590889 An04g04580 Aspergillus niger uncharacterized protein XP_059600552.1 1140365 R 5061 CDS An04g04590 4990866 complement(1142924..1143730) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein AAP25659.1 - Bacillus anthracis; uncharacterized protein 1143730 4990866 An04g04590 Aspergillus niger uncharacterized protein XP_001401825.1 1142924 R 5061 CDS An04g04600 84590890 complement(join(1143914..1144014,1144226..1144282,1144346..1144442)) VI 1 NT_166539.1 hypothetical protein 1144442 84590890 An04g04600 Aspergillus niger hypothetical protein XP_059600553.1 1143914 R 5061 CDS An04g04610 84590891 complement(join(1145341..1145387,1145484..1145580)) VI 1 NT_166539.1 Remark: the ORF is short in length (47 amino acids).; hypothetical protein 1145580 84590891 An04g04610 Aspergillus niger hypothetical protein XP_059600554.1 1145341 R 5061 CDS An04g04620 4990869 complement(1146227..1147384) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein encoded by An14g05440 - Aspergillus niger; uncharacterized protein 1147384 4990869 An04g04620 Aspergillus niger uncharacterized protein XP_001401828.1 1146227 R 5061 CDS An04g04630 4990870 complement(1147876..1149234) VI 1 NT_166539.1 Remark: the CAP59 gene is required for capsule formation. Capsule formation plays a significant role in the pathogenicity of Cryptococcus neoformans.; Title: strong similarity to capsule-associated protein CAP59 - Cryptococcus neoformans; See PMID 8007987; uncharacterized protein 1149234 4990870 An04g04630 Aspergillus niger uncharacterized protein XP_001401829.1 1147876 R 5061 CDS An04g04640 4990871 complement(join(1150450..1150770,1150835..1150928,1150981..1151044,1151101..1151202,1151252..1151570,1151639..1151944)) VI 1 NT_166539.1 Catalytic activity: geranyl diphosphate + isopentenyl diphosphate = pyrophosphate + trans,trans-farnesyl diphosphate; Pathway: sterol biosynthesis; terpenoid biosynthesis.; Remark: the rice pathogen, Gibberella fujikuroi,produces large amounts of gibberellins, a group of natural plant hormones, which induce the superelongation (bakanae) disease of rice. Gibberellins are diterpenoid compounds which are synthesized via the isoprenoid pathway.; Similarity: belongs to the geranylgeranyl pyrophosphate synthases.; Title: strong similarity to geranylgeranyl diphosphate synthase GGSII - Gibberella fujikuroi; See PMID 9230902; See PMID 9917370; uncharacterized protein 1151944 4990871 An04g04640 Aspergillus niger uncharacterized protein XP_059600555.1 1150450 R 5061 CDS An04g04650 84590892 complement(join(1152289..1152546,1152611..1152639,1152738..1153020)) VI 1 NT_166539.1 Similarity: the ORF shows weak similarity to the A. niger protein An16g00260. An16g00260, however, is much longer than the ORF (619 compared to 189 amino acids).; Title: weak similarity to hypothetical protein encoded by An16g00260 - Aspergillus niger; uncharacterized protein 1153020 84590892 An04g04650 Aspergillus niger uncharacterized protein XP_059600556.1 1152289 R 5061 CDS An04g04660 84590893 join(1153057..1153137,1153225..1153440) VI 1 NT_166539.1 hypothetical protein 1153440 84590893 An04g04660 Aspergillus niger hypothetical protein XP_059600557.1 1153057 D 5061 CDS An04g04670 4990874 join(1155633..1155707,1155762..1155825,1155873..1155906,1155964..1157011) VI 1 NT_166539.1 Catalytic activity: random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins.; Pathway: aminosugars metabolism.; Remark: expression of the CF/chitinase cDNA insert by using the pGEX-4T-3 vector yields a fusion peptide that bears CF-specific epitopes and shows chitinase activity.; Similarity: belongs to the chitinase family.; Title: strong similarity to chitinase cts1 -Coccidioides immitis; See PMID 8566773; See PMID 8675298; uncharacterized protein 1157011 4990874 An04g04670 Aspergillus niger uncharacterized protein XP_001401833.3 1155633 D 5061 CDS An04g04680 4990875 complement(join(1157232..1157276,1157437..1157929,1157978..1158175,1158226..1158369,1158427..1158652,1158742..1158979)) VI 1 NT_166539.1 Remark: this ORF represents an putative FAD dependent monooxygenase.; Similarity: belongs to the tetracycline 6-hydroxylase family.; Title: strong similarity to sequence 29 from patent WO0100842-A - Corynebacterium glutamicum; uncharacterized protein 1158979 4990875 An04g04680 Aspergillus niger uncharacterized protein XP_059600558.1 1157232 R 5061 CDS An04g04690 4990876 complement(join(1159515..1160208,1160268..1160739,1160789..1160884,1160946..1161234)) VI 1 NT_166539.1 Remark: acr-2 gene controls acriflavine sensitivity in N. crassa. The acr-2 mutation, which confers acriflavine resistance, substitutes the amino acid residue at position 303 of the encoded protein from asparagine to lysine. Progeny that were hypersensitive to acriflavine were obtained by disruption of the acr-2 gene by repeat induced point mutation (RIP).; Similarity: belongs to the GAL4 zinc binuclear cluster proteins.; Title: strong similarity to transcription factor involved in acriflavine resistance acr-2 - Neurospora crassa; nucleus; See PMID 8679704; uncharacterized protein 1161234 4990876 An04g04690 Aspergillus niger uncharacterized protein XP_001401835.1 1159515 R 5061 CDS An04g04700 4990877 join(1161791..1162480,1162540..1162569) VI 1 NT_166539.1 Catalytic activity: S-adenosyl-L-methionine + catechol = S-adenosyl-L-homocysteine + guaiacol.; Pathway: tyrosine metabolism.; Remark: strong similarity to human catechol-O-methyltransferase patent WO9111513-A.; Remark: the mammalian enzyme acts more rapidly on catecholamines such as adrenaline or noradrenaline than on catechols.; Similarity: belongs to the SAM-dependent methyltransferases.; Title: strong similarity to catechol-O-methyltransferase COMT from patent WO9111513-A -Homo sapiens; See PMID 11154093; See PMID 1847521; uncharacterized protein 1162569 4990877 An04g04700 Aspergillus niger uncharacterized protein XP_001401836.1 1161791 D 5061 CDS An04g04710 4990878 complement(1162787..1163578) VI 1 NT_166539.1 Remark: paiB from B. subtilis is essential for growth.; Title: similarity to transcription regulator 2 of pai operon paiB - Bacillus subtilis; See PMID 2108124; uncharacterized protein 1163578 4990878 An04g04710 Aspergillus niger uncharacterized protein XP_001401837.1 1162787 R 5061 CDS An04g04720 4990879 join(1164345..1164500,1164568..1165596) VI 1 NT_166539.1 Catalytic activity: L-cystathionine + H2O = L-cysteine + NH3 + 2-oxobutanoate.; Pathway: methionine metabolism; cysteine metabolism; selenoamino acid metabolism; nitrogen metabolism.; Remark: CYS3 is the structural gene for gamma-CTLase.; Similarity: similarity to other cystathionine gamma-lyases.; Title: strong similarity to cystathionine gamma-lyase - Saccharomyces cerevisiae; See PMID 8335636; See PMID 8511969; uncharacterized protein 1165596 4990879 An04g04720 Aspergillus niger uncharacterized protein XP_059600559.1 1164345 D 5061 CDS An04g04730 4990880 1167147..1169840 VI 1 NT_166539.1 Title: weak similarity to retinitis pigmentosa GTPase regulator-like protein RPGR - Takifugu rubripes; See PMID 10932196; uncharacterized protein 1169840 4990880 An04g04730 Aspergillus niger uncharacterized protein XP_001401839.1 1167147 D 5061 CDS An04g04740 4990881 1170808..1173936 VI 1 NT_166539.1 Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: weak similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942; uncharacterized protein 1173936 4990881 An04g04740 Aspergillus niger uncharacterized protein XP_001401840.1 1170808 D 5061 CDS An04g04750 4990882 join(1175281..1175484,1175590..1177640,1177691..1178064,1178119..1178657) VI 1 NT_166539.1 Catalytic activity: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2.; Function: the 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-Coa & CO(2). it contains multiple copies of 3 enzymatic components: 2-oxoglutarate dehydrogenase (E1),dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).; Pathway: citrate cycle (TCA cycle); lysine degradation; tryptophan metabolism.; Similarity: similarity to other oxoglutarate dehydrogenases.; Title: strong similarity to oxoglutarate dehydrogenase (lipoamide) Kgd1 - Saccharomyces cerevisiae; See PMID 2072900; See PMID 2503710; See PMID 8299151; uncharacterized protein 1178657 4990882 An04g04750 Aspergillus niger uncharacterized protein XP_001401841.1 1175281 D 5061 CDS An04g04770 4990884 join(1179471..1179821,1179933..1180603,1180654..1180859,1180917..1181471,1181534..1181592) VI 1 NT_166539.1 Title: similarity to hypothetical protein CG6632 -Drosophila melanogaster; uncharacterized protein 1181592 4990884 An04g04770 Aspergillus niger uncharacterized protein XP_059600560.1 1179471 D 5061 CDS An04g04790 4990886 complement(join(1183901..1184316,1184376..1184601,1184666..1185274)) VI 1 NT_166539.1 Remark: the CAP59 gene is required for capsule formation. Capsule formation plays a significant role in the pathogenicity of Cryptococcus neoformans.; Title: strong similarity to capsule-associated protein CAP59 - Cryptococcus neoformans; See PMID 8007987; uncharacterized protein 1185274 4990886 An04g04790 Aspergillus niger uncharacterized protein XP_001401843.1 1183901 R 5061 CDS An04g04800 4990887 complement(join(<1185995..1186253,1186302..1186486,1186584..1186850)) VI 1 NT_166539.1 Remark: C-terminally truncated ORF due to contig border.; Title: strong similarity to hypothetical protein SPAC1486.02c - Schizosaccharomyces pombe [truncated ORF]; uncharacterized protein 1186850 4990887 An04g04800 Aspergillus niger uncharacterized protein XP_059600561.1 1185995 R 5061 CDS An04g04810 4990888 complement(join(1187161..1188902,1188959..1189100)) VI 1 NT_166539.1 Complex: TFB1 of S. cerevisiae is a subunit of the RNA polymerase II basal transcription factor TFIIH complex,that is composed also by the subunits TFB2, TFB3, TFB4,KIN28, RAD3, SSL1, SSL2, and CCL1.; Function: TFIIH is essential for transcription and nucleotide excision DNA repair.; Phenotype: S. cerevisiae TFB1 null mutants are inviable.; Title: strong similarity to subunit of transcription initiation factor TFIIH Tfb1 - Saccharomyces cerevisiae; nucleus; See PMID 1445600; See PMID 10214907; uncharacterized protein 1189100 4990888 An04g04810 Aspergillus niger uncharacterized protein XP_001401845.1 1187161 R 5061 CDS An04g04820 4990889 join(1190013..1190099,1190235..1190471,1190532..1191125,1191488..1191623,1191746..1192101,1192168..1192347,1192432..1192857) VI 1 NT_166539.1 Similarity: the ORF shows weak similarity to the A. niger protein:An01g07840. The ORF is much longer than An01g07840 (671 compared to 278 amino acids).; Similarity: the predicted ORF shows also weak local similarity with a putative nitrite reductase large subunit of Streptomyces coelicolor.; Title: weak similarity to hypothetical protein encoded by An01g07840 - Aspergillus niger; uncharacterized protein 1192857 4990889 An04g04820 Aspergillus niger uncharacterized protein XP_001401846.3 1190013 D 5061 CDS An04g04830 84590894 complement(join(1192900..1192955,1193045..1193083,1193234..1193303)) VI 1 NT_166539.1 hypothetical protein 1193303 84590894 An04g04830 Aspergillus niger hypothetical protein XP_059600562.1 1192900 R 5061 CDS An04g04840 4990891 join(1193638..1193679,1193744..1193812,1193869..1193927,1193989..1194178,1194237..1194345,1194404..1194471) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein SPAC227.16c - Schizosaccharomyces pombe; uncharacterized protein 1194471 4990891 An04g04840 Aspergillus niger uncharacterized protein XP_001401848.1 1193638 D 5061 CDS An04g04850 84590895 join(<1195463..1195612,1195828..1196076) VI 1 NT_166539.1 Remark: truncated ORF due to end of contig.; hypothetical protein [truncated ORF] 1196076 84590895 An04g04850 Aspergillus niger hypothetical protein [truncated ORF] XP_059600563.1 1195463 D 5061 CDS An04g04860 4990893 complement(1196448..1197923) VI 1 NT_166539.1 Remark: it is used in the method of the invention which involves the use of a mutant cell with a nucleic acid construct introduced into a locus; the methods can be used for producing metabolites.; Remark: this is the nucleotide sequence of a rescued locus from the mutant Aspergillus oryzae DEBY1058.; Title: similarity to sequence 29 from patent WO9811203-A1 - Aspergillus oryzae; uncharacterized protein 1197923 4990893 An04g04860 Aspergillus niger uncharacterized protein XP_001401850.1 1196448 R 5061 CDS An04g04870 4990894 complement(join(1198282..1198372,1198430..1198497,1198554..1198960,1199026..1199155)) VI 1 NT_166539.1 Catalytic activity: O2. - + O2. - + 2 H+ = O2 + H2O2.; Complex: homotetramer.; Function: destroys radicals which are normally produced within the cells and are toxic to biological systems.; Localization: mitochondrial matrix.; Remark: eukaryotic cells contain a mitochondrial Mn-containing enzyme and a cytoplasmic Cu-Zn containing enzyme.; Title: strong similarity to superoxide dismutase Sod2 - Saccharomyces cerevisiae; uncharacterized protein 1199155 4990894 An04g04870 Aspergillus niger uncharacterized protein XP_001401851.1 1198282 R 5061 CDS An04g04880 4990895 1199480..1201807 VI 1 NT_166539.1 Title: strong similarity to tuftelin-interacting protein 39 - Mus musculus; See PMID 11063033; uncharacterized protein 1201807 4990895 An04g04880 Aspergillus niger uncharacterized protein XP_001401852.1 1199480 D 5061 CDS An04g04890 4990896 complement(join(1202389..1202673,1202732..1202898,1202961..1203955,1204024..1204289)) VI 1 NT_166539.1 Catalytic activity: ATP + glycerol = ADP + glycerol 3-phosphate.; Pathway: rate limiting step in glycerol utilization.; Remark: glycerone and L-glyceraldehyde can act as acceptors; UTP can act as donors.; Title: strong similarity to glycerol kinase GK - Mus musculus; uncharacterized protein 1204289 4990896 An04g04890 Aspergillus niger uncharacterized protein XP_001401853.3 1202389 R 5061 CDS An04g04900 84590896 join(1204399..1204453,1204592..1204646,1204697..1204808,1204883..1205072,1205261..1205516,1205601..1205754,1205838..1205921) VI 1 NT_166539.1 hypothetical protein 1205921 84590896 An04g04900 Aspergillus niger hypothetical protein XP_059600564.1 1204399 D 5061 CDS An04g04910 84590897 join(1206565..1206582,1206685..1206844,1206930..1207078) VI 1 NT_166539.1 hypothetical protein 1207078 84590897 An04g04910 Aspergillus niger hypothetical protein XP_059600565.1 1206565 D 5061 CDS An04g04920 84590898 complement(join(1207224..1207344,1207426..1207490,1207626..1207739,1207792..1207831,1207920..1208009,1208036..1208115)) VI 1 NT_166539.1 hypothetical protein 1208115 84590898 An04g04920 Aspergillus niger hypothetical protein XP_059600566.1 1207224 R 5061 CDS An04g04930 84590899 complement(join(1208405..1208487,1208579..1208653,1208739..1208777,1208865..1208898,1209074..1209219,1209370..1209448)) VI 1 NT_166539.1 hypothetical protein 1209448 84590899 An04g04930 Aspergillus niger hypothetical protein XP_059600567.1 1208405 R 5061 CDS An04g04940 4990901 complement(join(1209871..1210293,1210386..1210610,1210721..1210765,1210830..1211048)) VI 1 NT_166539.1 Title: similarity to EST SEQ ID NO:6012 from patent WO200056762-A2 - Aspergillus oryzae; uncharacterized protein 1211048 4990901 An04g04940 Aspergillus niger uncharacterized protein XP_001401858.1 1209871 R 5061 CDS An04g04950 4990902 join(1212219..1219649,1219700..1221317,1221369..1221785,1221841..1221881) VI 1 NT_166539.1 Function: promotes endosomal cycling of TGN (trans-Golgi network) membrane proteins by modulating the function of two cytosolic TGN localization signals.; Remark: Null mutant is viable but exhibits defects in vacuolar protein sorting.; Title: strong similarity to vacuolar protein sorting-associated protein Vps13 - Saccharomyces cerevisiae; See PMID 11402063; uncharacterized protein 1221881 4990902 An04g04950 Aspergillus niger uncharacterized protein XP_001401859.1 1212219 D 5061 CDS An04g04960 84590900 complement(join(1222439..1222507,1222558..1222803)) VI 1 NT_166539.1 hypothetical protein 1222803 84590900 An04g04960 Aspergillus niger hypothetical protein XP_059600568.1 1222439 R 5061 CDS An04g04970 4990904 complement(join(1224085..1224474,1224525..1226257,1226315..1226429,1226491..1226634,1226697..1226726)) VI 1 NT_166539.1 Cofactor: the S. cerevisiae YAT11 binds and requires a zinc atom.; Function: the S. cerevisiae YAT11 is an ATP-dependent protease which causes an increased escape of DNA from mitochondria; and it is necessary to maintain the integrity of the mitochondrial compartment.; Function: the S. cerevisiae YAT11 is required both for the degradation of unassembled subunit 2 of cytochrome C oxidase and for efficient assembly of mitochondrial respiratory chain.; Similarity: the S. cerevisiae YAT11 belongs to the AAA family of ATPases.; Title: strong similarity to Yta11 - Saccharomyces cerevisiae; uncharacterized protein 1226726 4990904 An04g04970 Aspergillus niger uncharacterized protein XP_001401861.1 1224085 R 5061 CDS An04g04980 4990905 1227508..1228587 VI 1 NT_166539.1 hypothetical protein 1228587 4990905 An04g04980 Aspergillus niger hypothetical protein XP_001401862.3 1227508 D 5061 CDS An04g04990 4990906 join(1230038..1230044,1230101..1230144,1230253..1230399,1230457..1231333,1231386..1231405) VI 1 NT_166539.1 Catalytic activity: GTP + alpha-D-mannose 1-phoshate = diphosphate + GDP-mannose.; Function: mannose-1-phosphate guanyltransferase is involved in early steps of of protein glycosylation.; Title: strong similarity to mannose-1-phosphate guanyltransferase MPG1 - Trichoderma reesei; See PMID 9644208; uncharacterized protein 1231405 4990906 An04g04990 Aspergillus niger uncharacterized protein XP_001401863.1 1230038 D 5061 CDS An04g05000 4990907 complement(join(1232039..1232579,1232631..1233287,1233391..1233455)) VI 1 NT_166539.1 Remark: protein AN80 is one of four new proteins discovered in A. nidulans that are essential for survival.; Title: strong similarity to hypothetical protein AN80 from patent WO9924580-A2 - Aspergillus nidulans; uncharacterized protein 1233455 4990907 An04g05000 Aspergillus niger uncharacterized protein XP_059600569.1 1232039 R 5061 CDS An04g05010 84590901 complement(join(1236857..1237059,1237132..1237274,1237436..1237685,1238180..1238244,1238362..1238614,1238734..1238856,1238956..1239082)) VI 1 NT_166539.1 hypothetical protein 1239082 84590901 An04g05010 Aspergillus niger hypothetical protein XP_059600570.1 1236857 R 5061 CDS An04g05020 84590902 join(1239142..1239240,1239388..1239735) VI 1 NT_166539.1 Title: questionable ORF; uncharacterized protein 1239735 84590902 An04g05020 Aspergillus niger uncharacterized protein XP_059600571.1 1239142 D 5061 CDS An04g05030 84590903 complement(join(1240842..1241002,1241059..1241311)) VI 1 NT_166539.1 hypothetical protein 1241311 84590903 An04g05030 Aspergillus niger hypothetical protein XP_059600572.1 1240842 R 5061 CDS An04g05040 84590904 complement(join(1241653..1241825,1242138..1242355,1242451..1242539)) VI 1 NT_166539.1 hypothetical protein 1242539 84590904 An04g05040 Aspergillus niger hypothetical protein XP_059600573.1 1241653 R 5061 CDS An04g05050 84590905 complement(join(1243499..1243819,1243971..1244012)) VI 1 NT_166539.1 Title: questionable ORF; uncharacterized protein 1244012 84590905 An04g05050 Aspergillus niger uncharacterized protein XP_059600574.1 1243499 R 5061 CDS An04g05060 4990913 join(1244142..1244195,1244287..1244478,1244527..1244606,1244657..1245185) VI 1 NT_166539.1 Domain: contains 37 finger motifs in 6 domains.; Function: binds RNA; could function in post-translational regulation processes.; Remark: belongs to the krueppel subfamily of C2H2-type zinc-finger proteins; phosphoprotein.; Title: similarity to protein XFIN - Xenopus laevis; uncharacterized protein 1245185 4990913 An04g05060 Aspergillus niger uncharacterized protein XP_001401870.1 1244142 D 5061 CDS An04g05070 84590906 join(1245794..1245907,1246021..1246251) VI 1 NT_166539.1 hypothetical protein 1246251 84590906 An04g05070 Aspergillus niger hypothetical protein XP_059600575.1 1245794 D 5061 CDS An04g05080 84590907 join(1246871..1246949,1247076..1247116,1247204..1247243,1247358..1247467,1247529..1247579) VI 1 NT_166539.1 hypothetical protein 1247579 84590907 An04g05080 Aspergillus niger hypothetical protein XP_059600576.1 1246871 D 5061 CDS An04g05090 84590908 join(1250246..1250401,1250460..1250498,1250551..1250574) VI 1 NT_166539.1 Title: weak similarity to hypothetical secreted protein encoded by SCE41.06c - Streptomyces coelicolor; uncharacterized protein 1250574 84590908 An04g05090 Aspergillus niger uncharacterized protein XP_059600577.1 1250246 D 5061 CDS An04g05100 4990917 complement(join(1250687..1253392,1253455..1253487)) VI 1 NT_166539.1 Localization: Subcellular localization studies of a tagged version of Gpi13 suggest that this protein is mainly in the ER.; Phenotype: Gpi13-depleted S. cerevisiae cells accumulate GPI intermediates with the structures Manalpha1-2Manalpha1-2Manalpha1-6[NH(2)-(CH(2))(2)-PO(4)-- >]Manalpha1 -4GlcNalpha1-6[acyl-->]inositol-PO(4)-lipid and Manalpha1-2Manalpha1-2Manalpha1-6Manalpha1-4G lcNalpha1-6[acyl-->]inositol-PO(4)-lipid.; Phenotype: depletion of Gpi13 from S. cerevisiae results in a reduction of glycosylphosphatidylinositol (GPI) anchor addition to GPI proteins as well as in cell wall fragility.; Remark: the synonym for Gpi13 from S. cerevisiae is YLL031c.; Similarity: Gpi13 is a member of a family of phosphoryltransferases,; Title: strong similarity to protein involved in glycosylphosphatidylinositol biosynthesis Gpi13 -Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 10793139; See PMID 10823837; uncharacterized protein 1253487 4990917 An04g05100 Aspergillus niger uncharacterized protein XP_001401874.1 1250687 R 5061 CDS An04g05110 4990918 complement(join(1254625..1255374,1255474..1255845)) VI 1 NT_166539.1 Remark: the matching coding sequence was isolated by RT-PCR on all of the mRNA from A. thaliana.; Remark: there are no further informations about the patent available.; Title: similarity to protein fragment SEQ ID NO:12845 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 1255845 4990918 An04g05110 Aspergillus niger uncharacterized protein XP_001401875.1 1254625 R 5061 CDS An04g05120 4990919 complement(1256276..1257517) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein CAB91749.2 - Neurospora crassa; uncharacterized protein 1257517 4990919 An04g05120 Aspergillus niger uncharacterized protein XP_001401876.1 1256276 R 5061 CDS An04g05130 4990920 complement(join(1257866..1258467,1258539..1258824,1258912..1259387,1259623..1259704)) VI 1 NT_166539.1 Catalytic activity: Aspartate + 2-Oxoglutarate = Oxaloacetate + Glutamate.; Cofactor: Pyridoxal phosphate.; Remark: The matched protein sequence of patent WO9729187-A1 comprises aspartate aminotransferase VF5/AA of Aquifex VF5, a strictly chemolithoautotrophic marine eubacterium which grows optimally at 85-90 deg C and pH 6. 8 in high salt medium.; Title: strong similarity to aspartate aminotransferase VF5 from patent WO9729187-A1 - Aquifex sp.; uncharacterized protein 1259704 4990920 An04g05130 Aspergillus niger uncharacterized protein XP_001401877.1 1257866 R 5061 CDS An04g05140 84590909 join(1260058..1260183,1260382..1260583,1260748..1260884) VI 1 NT_166539.1 hypothetical protein 1260884 84590909 An04g05140 Aspergillus niger hypothetical protein XP_059600578.1 1260058 D 5061 CDS An04g05150 4990922 complement(join(1261695..1263058,1263119..1263305,1263358..1263606,1263666..1264640)) VI 1 NT_166539.1 Complex: the S. pombe proteins scd1, scd2, cdc42,and ras1, in its GTP-bound state, act cooperatively to form a protein complex.; Function: scd1 from S. pombe is a regulator of the Cdc42 GTPase.; Function: scd1 from S. pombe is required for mating and morphogenesis.; Localization: scd1 from S. pombe localizes in the nucleus.; Phenotype: loss of function in scd1 from S. pombe induced abnormality in the spindle.; Similarity: to other guanine-nucleotide releasing factors of the Cdc24 family.; Title: strong similarity to guanine nucleotide exchange factor scd1p - Schizosaccharomyces pombe; nucleus; See PMID 9892665; See PMID 7923372; uncharacterized protein 1264640 4990922 An04g05150 Aspergillus niger uncharacterized protein XP_001401879.1 1261695 R 5061 CDS An04g05160 84590910 join(1265189..1265403,1265445..1265709) VI 1 NT_166539.1 Similarity: the similarities are mainly based on repetetive structures.; Title: weak similarity to retinitis pigmentosa GTPase regulator RPGR - Homo sapiens; uncharacterized protein 1265709 84590910 An04g05160 Aspergillus niger uncharacterized protein XP_059600579.1 1265189 D 5061 CDS An04g05170 84590911 join(1266701..1266838,1266923..1267015,1267116..1267271,1267396..1267569) VI 1 NT_166539.1 hypothetical protein 1267569 84590911 An04g05170 Aspergillus niger hypothetical protein XP_059600580.1 1266701 D 5061 CDS An04g05180 4990925 join(1269034..1269268,1269378..1270500,1270624..1271851) VI 1 NT_166539.1 Function: transient over-expression of human delta-beta-TrCP (a deletion mutant) inhibited the degradation of endogenous I-kappa-B-alpha in stimulated Jurkat cells, resulting in accumulation of phosphorylated I-kappa-B-alpha.; Remark: E3 enhances ubiquitination of phosphorylated I-kappa-B, an inhibitor protein of nuclear factor kappa-B (NF-kappa-B).; Remark: human beta-TrCP can be used to modulate NF-kappa-B to treat inflammatory diseases, autoimmune diseases, cancer and viral infections.; Similarity: human beta-TrCP is an F-box/WD protein family member and shows homology to human E3 ubiquitin ligase (E3).; Title: strong similarity to E3 ubiquitin ligase beta-TrCP from patent WO200034447-A2 - Homo sapiens; See PMID 10437795; uncharacterized protein 1271851 4990925 An04g05180 Aspergillus niger uncharacterized protein XP_059600581.1 1269034 D 5061 CDS An04g05190 4990926 complement(1272530..1274194) VI 1 NT_166539.1 Title: weak similarity to pancreatic islet homeobox gene Nkx6.1 - Homo sapiens; uncharacterized protein 1274194 4990926 An04g05190 Aspergillus niger uncharacterized protein XP_001401883.1 1272530 R 5061 CDS An04g05200 84590912 1274744..1275217 VI 1 NT_166539.1 Title: weak similarity to protein fragment SEQ ID NO:3484 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 1275217 84590912 An04g05200 Aspergillus niger uncharacterized protein XP_059600582.1 1274744 D 5061 CDS An04g05210 4990928 join(1275461..1275589,1275651..1275763,1275842..1276190,1276280..1277146) VI 1 NT_166539.1 Remark: Feline leukemia virus-C (FeLV-C) causes red cell aplasia in cats, through its interaction with its cell surface receptor FLVCR1.; Similarity: FLVCR1 from F. catus is a member of the major facilitator superfamily of transporters and shows homologies especially to D-glucarate transporters.; Title: strong similarity to feline leukemia virus subgroup C receptor FLVCR1 - Felis catus; See PMID 10648427; uncharacterized protein 1277146 4990928 An04g05210 Aspergillus niger uncharacterized protein XP_001401885.3 1275461 D 5061 CDS An04g05220 4990929 complement(join(1277780..1277844,1277950..1278072,1278297..1278612)) VI 1 NT_166539.1 Catalytic activity: QH2 + 2 Ferricytochrome c = Q + 2 Ferrocytochrome c; Cofactor: Cytochrome b-562, Cytochrome b-566,Cytochrome c1, 2-Iron ferredoxin.; Complex: Qcr6 from S. cerevisiae is one of the components of the complex III or cytochrome b-c1 complex.; Function: qcr6 null mutant of S. cerevisiae is blocked in processing of cytochrome c1 to mature size.; Phenotype: qcr6 null mutant of S. cerevisiae can grow on nonfermentable carbon sources, but has half of the normal ubiquinol cytochrome-c reductase activity.; Remark: synonyms for Qcr6 from S. cerevisiae are Ucr6, Cor3 and YFR033c.; Title: strong similarity to subunit 6 of ubiquinol--cytochrome-c reductase Qcr6 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8288589; See PMID 2170363; uncharacterized protein 1278612 4990929 An04g05220 Aspergillus niger uncharacterized protein XP_001401886.1 1277780 R 5061 CDS An04g05230 4990930 complement(join(1279087..1279605,1279666..1279837,1280128..1280138)) VI 1 NT_166539.1 Remark: the matching coding sequence was isolated by RT-PCR on all of the mRNA from A. thaliana.; Remark: there are no further informations about the patent available.; Title: similarity to protein fragment SEQ ID NO:2344 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 1280138 4990930 An04g05230 Aspergillus niger uncharacterized protein XP_001401887.1 1279087 R 5061 CDS An04g05240 84590913 join(1280477..1280525,1280619..1281077,1281152..1281201,1281279..1281383) VI 1 NT_166539.1 hypothetical protein 1281383 84590913 An04g05240 Aspergillus niger hypothetical protein XP_059600583.1 1280477 D 5061 CDS An04g05250 4990932 join(1282629..1282853,1282933..1283267,1283574..1283904) VI 1 NT_166539.1 Function: the cis-prenyltransferase Rer2 from S. cerevisiae is a key enzyme of the dolichol synthesis.; Phenotype: the rer2 mutant of S. cerevisiae shows slow growth, defects in N and O glycosylation, sensitivity to hygromycin B, and abnormal accumulation of membranes,including the ER and the Golgi membranes.; Phenotype: the temperature-sensitive rer2 mutant of S. cerevisiae mislocalizes different types of ER membrane proteins.; Remark: Dolichol is a family of long-chain polyprenols, which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum.; Remark: the synonym for Rer2 from S. cerevisiae is YBR002c.; Title: strong similarity to undecaprenyl phosphate synthase Rer2 from patent WO200121650-A2 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 9858571; uncharacterized protein 1283904 4990932 An04g05250 Aspergillus niger uncharacterized protein XP_059600584.1 1282629 D 5061 CDS An04g05260 4990933 join(1284354..1284399,1284483..1284536,1284634..1284920,1284980..1285018,1285080..1285134,1285195..1285964,1286045..1286140) VI 1 NT_166539.1 Catalytic activity: N6-(L-1,3-Dicarboxypropyl)-L-lysine + NADP+ + H2O = L-Glutamate + L-2-Aminoadipate 6-semialdehyde + NADPH.; Complex: saccharopine reductase from M. grisea is a homodimer.; Function: saccharopine reductase from M. grisea is an enzyme of the alpha-aminoadipic pathway of lysine biosynthesis.; Similarity: the ORF also shows strong similarity to the EST SEQ ID NO:6253 of patent WO200056762-A2 from Aspergillus oryzae.; Title: strong similarity to saccharopine reductase LYS3 - Magnaporthe grisea; See PMID 10771443; See PMID 11080625; uncharacterized protein 1286140 4990933 An04g05260 Aspergillus niger uncharacterized protein XP_001401890.1 1284354 D 5061 CDS An04g05270 4990934 complement(join(1286632..1286650,1286767..1287425,1287491..1287573,1287638..1287860)) VI 1 NT_166539.1 Function: Adr1 from S. cerevisiae is a zinc-finger transcription factor and involved in regulation of ADH2 and peroxisomal genes.; Remark: a splice site was detected upstream of the START codon.; Remark: the synonym for Adr1 from S. cerevisiae is YDR214w.; Repression: Adr1 from S. cerevisiae is inactivated by phosphorylation at Ser230 by protein kinase A.; Title: strong similarity to transcription activator Adr1 - Saccharomyces cerevisiae; nucleus; See PMID 9742103; See PMID 1427033; See PMID 6341814; uncharacterized protein 1287860 4990934 An04g05270 Aspergillus niger uncharacterized protein XP_001401891.1 1286632 R 5061 CDS An04g05280 4990935 complement(join(1288804..1292315,1292456..1292904,1293013..1293242)) VI 1 NT_166539.1 Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942; uncharacterized protein 1293242 4990935 An04g05280 Aspergillus niger uncharacterized protein XP_001401892.1 1288804 R 5061 CDS An04g05290 84590914 complement(join(1294410..1294461,1294602..1294642,1294858..1294905)) VI 1 NT_166539.1 Title: questionable ORF; uncharacterized protein 1294905 84590914 An04g05290 Aspergillus niger uncharacterized protein XP_059600585.1 1294410 R 5061 CDS An04g05300 4990937 join(1296907..1297034,1297102..1298041) VI 1 NT_166539.1 Catalytic activity: D-Fructose 1,6-bisphosphate + H2O = D-Fructose 6-phosphate + Orthophosphate.; Catalytic activity: Sedoheptulose 1,7-bisphosphate + H2O = Sedoheptulose 7-phosphate + Orthophosphate.; Repression: Expression of fbpA from A. oryzae is repressed in the presence of glucose, but not in the presence of pyruvate or sodium acetate in the medium.; Title: strong similarity to fructose-1,6-bisphosphatase fbpA - Aspergillus oryzae; See PMID 10993168; uncharacterized protein 1298041 4990937 An04g05300 Aspergillus niger uncharacterized protein XP_001401894.1 1296907 D 5061 CDS An04g05310 4990938 complement(join(1300151..1301032,1301083..1302548,1302612..1302690,1302766..1302891)) VI 1 NT_166539.1 Catalytic activity: ATP + H2O = ADP + Orthophosphate.; Complex: Vph1-containing complexes in S. cerevisiae present in the vacuole showed dissociation in response to glucose depletion.; Localization: Vph1p is a vacuolar integral membrane protein.; Phenotype: Deletion of the VPH1 from S. cerevisiae gene revealed that the VPH1 gene is not essential for viability but is required for vacuolar H(+)-ATPase assembly and vacuolar acidification.; Remark: the synonym for Vph1 from S. cerevisiae is YOR270c.; Similarity: the ORF also shows strong similarity to the EST an_2746 from Aspergillus niger.; Title: strong similarity to vacuolar H(+)-transporting ATPase subunit Vph1 - Saccharomyces cerevisiae; vacuole; See PMID 11278748; See PMID 1385813; uncharacterized protein 1302891 4990938 An04g05310 Aspergillus niger uncharacterized protein XP_001401895.1 1300151 R 5061 CDS An04g05320 4990939 complement(join(1303488..1303550,1303619..1309016,1309074..1309504)) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein TEMO - Rattus norvegicus; uncharacterized protein 1309504 4990939 An04g05320 Aspergillus niger uncharacterized protein XP_001401896.1 1303488 R 5061 CDS An04g05330 4990940 complement(join(1310347..1310785,1310841..1311422,1311500..1311879)) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein SPAC18B11.05 - Schizosaccharomyces pombe; uncharacterized protein 1311879 4990940 An04g05330 Aspergillus niger uncharacterized protein XP_059600586.1 1310347 R 5061 CDS An04g05340 84590915 complement(join(1313141..1313236,1313359..1313386,1313477..1313559,1313598..1313665,1313774..1313852,1313942..1313981,1314077..1314183)) VI 1 NT_166539.1 hypothetical protein 1314183 84590915 An04g05340 Aspergillus niger hypothetical protein XP_059600587.1 1313141 R 5061 CDS An04g05350 84590916 complement(join(1314769..1314895,1314934..1315067,1315406..1315526,1315633..1315761,1315815..1315888)) VI 1 NT_166539.1 Similarity: weak similarities due to multiple serine and glycine repeats.; hypothetical protein 1315888 84590916 An04g05350 Aspergillus niger hypothetical protein XP_059600588.1 1314769 R 5061 CDS An04g05360 4990943 1315976..1317739 VI 1 NT_166539.1 Remark: a splice site was detected upstream of the START codon.; Similarity: similarities correspond to multiple serine repeats.; Title: weak similarity to dentin sialophosphoprotein from patent WO200062065-A1 - Homo sapiens; uncharacterized protein 1317739 4990943 An04g05360 Aspergillus niger uncharacterized protein XP_059600589.1 1315976 D 5061 CDS An04g05370 84590917 complement(join(1318125..1318237,1318296..1318302)) VI 1 NT_166539.1 Title: questionable ORF; uncharacterized protein 1318302 84590917 An04g05370 Aspergillus niger uncharacterized protein XP_059600590.1 1318125 R 5061 CDS An04g05380 4990945 complement(join(1318638..1319144,1319200..1319556,1319613..1319763,1319830..1319861)) VI 1 NT_166539.1 Remark: C. albicans 6C5 protein is also useful in diagnostic tests (i. e. detect, diagnose and serotype yeast infection), and for detecting the presence of Candida and other pathogenic yeasts, in a biological sample.; Remark: the C. albicans 6C5 antigen is a hydrophobic cell wall protein that, together with the corresponding antibody, can be used to diagnose and treat infections with pathogenic yeasts.; Similarity: similarities to oxidoreductases involved in carbohydrate-utilization resp. energy generation.; Title: strong similarity to cell wall antigen 6C5 from patent WO200048620-A1 - Candida albicans; uncharacterized protein 1319861 4990945 An04g05380 Aspergillus niger uncharacterized protein XP_001401902.1 1318638 R 5061 CDS An04g05390 84590918 join(1320144..1320246,1320349..1320572) VI 1 NT_166539.1 Similarity: similarities correspond to multiple serine repeats.; Title: weak similarity to hypothetical protein PFB0700c - Plasmodium falciparum; uncharacterized protein 1320572 84590918 An04g05390 Aspergillus niger uncharacterized protein XP_059600591.1 1320144 D 5061 CDS An04g05400 84590919 complement(join(1320624..1320985,1321136..1321252,1321332..1321422,1321996..1322169)) VI 1 NT_166539.1 hypothetical protein 1322169 84590919 An04g05400 Aspergillus niger hypothetical protein XP_059600592.1 1320624 R 5061 CDS An04g05410 4990948 join(1322478..1322863,1322915..1322987,1323051..1323176) VI 1 NT_166539.1 hypothetical protein 1323176 4990948 An04g05410 Aspergillus niger hypothetical protein XP_001401905.1 1322478 D 5061 CDS An04g05420 4990949 complement(join(1323894..1324197,1324265..1324589,1324645..1327936,1328008..1328379)) VI 1 NT_166539.1 Catalytic activity: l-2-aminoadipate 6-semialdehyde + NADP(+) + H(2)O = l-2-aminoadipate + NADPH.; Complex: the aminoadipate reductase enzyme is a heterodimer of a large (lys2) and a small subunit.; Function: lys2 of P. chrysogenum, as well as of S. cerevisiae, catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH.; Pathway: lysine biosynthesis.; Remark: disruption of P. crysogenum lys2 leads to mutants lacking alpha-aminoadipate reductase activity,showing penicillin yields double those of the parental nondisrupted strain.; Title: strong similarity to alpha-aminoadipate reductase large subunit lys2 - Penicillium chrysogenum; See PMID 9790587; See PMID 9973344; See PMID 10485291; uncharacterized protein 1328379 4990949 An04g05420 Aspergillus niger uncharacterized protein XP_001401906.3 1323894 R 5061 CDS An04g05430 4990950 join(1329255..1330954,1330993..1331059) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein CAD21051.1 - Neurospora crassa; uncharacterized protein 1331059 4990950 An04g05430 Aspergillus niger uncharacterized protein XP_059600593.1 1329255 D 5061 CDS An04g05440 4990951 join(1331844..1332077,1332131..1332334,1332387..1334341,1334390..1336073) VI 1 NT_166539.1 Catalytic activity: xanthine + H(2)O + O(2) = urate + H(2)O(2).; Catalytic activity: xanthine + NAD(+) + H(2)O = urate + NADH.; Cofactor: FAD, molybdopterin, and two 2fe-2s centers.; Complex: homodimer.; Function: Xanthine dehydrogenase is a molybdenum iron-sulphur flavin hydroxylase which oxidizes a variety of purines, pterins and other heterogenic nitrogen compounds,serving as a rate-limiting enzyme in nucleic acid degradation.; Pathway: purine catabolism; Remark: Xanthine dehydrogenase can be converted from the dehydrogenase form (d) to the oxidase form (o) irreversibly by proteolysis or reversibly through the oxidation of sulfhydryl groups.; Remark: Xanthine dehydrogenase contains four cofactors per subunit, one FAD, two iron-sulfur clusters,and one molybdopterin.; Remark: Xanthine dehydrogenase is reversibly converted to xanthine oxidase by oxidized glutathione catalyzed by enzyme-thiol transhydrogenase (oxidized-glutathione) (EC 1. 8. 4. 7).; Remark: the reversible conversion to xanthine oxidase can also be performed artificially by a variety of sulfhydryl reagents. An irreversible conversion can be performed by limited proteolysis.; Title: strong similarity to xanthine dehydrogenase XDH - Homo sapiens; See PMID 8135849; uncharacterized protein 1336073 4990951 An04g05440 Aspergillus niger uncharacterized protein XP_001401908.1 1331844 D 5061 CDS An04g05450 4990952 complement(join(1336865..1337213,1337264..1338127,1338191..1338930)) VI 1 NT_166539.1 Similarity: the ORF shows strong similarity to the A. niger protein An09g05620. However, the ORF is much longer than the other An09g05620 (650 compared to 152 amino acids).; Title: similarity to hypothetical protein encoded by An09g05620 - Aspergillus niger; uncharacterized protein 1338930 4990952 An04g05450 Aspergillus niger uncharacterized protein XP_001401909.3 1336865 R 5061 CDS An04g05460 4990953 complement(1339290..1341509) VI 1 NT_166539.1 Title: strong similarity to hypothetical membrane protein YNL279w - Saccharomyces cerevisiae; uncharacterized protein 1341509 4990953 An04g05460 Aspergillus niger uncharacterized protein XP_001401910.1 1339290 R 5061 CDS An04g05470 84590920 join(1341855..1341921,1342090..1342204,1342429..1342497,1342597..1342906) VI 1 NT_166539.1 hypothetical protein 1342906 84590920 An04g05470 Aspergillus niger hypothetical protein XP_059600594.1 1341855 D 5061 CDS An04g05480 4990955 join(1343147..1343262,1343428..1343466,1343520..1343584,1343670..1345328,1345392..1345873) VI 1 NT_166539.1 Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942; uncharacterized protein 1345873 4990955 An04g05480 Aspergillus niger uncharacterized protein XP_001401912.3 1343147 D 5061 CDS An04g05490 4990956 complement(join(1346366..1346653,1346708..1347131,1347183..1347196,1347254..1347407,1347457..1347529,1347581..1347686,1347741..1347825,1347889..1347957,1348014..1348210)) VI 1 NT_166539.1 Similarity: similarities to pro- and eukaryotic aminotransferases.; Title: strong similarity to protein fragment SEQ ID NO:4306 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 1348210 4990956 An04g05490 Aspergillus niger uncharacterized protein XP_001401913.1 1346366 R 5061 CDS An04g05500 4990957 1348940..1350535 VI 1 NT_166539.1 Remark: the WHIP protein of M. musculus interacts with the N-terminal portion of Werner protein (WRN),containing the exonuclease domain.; Remark: the WHIP protein of M. musculus shows homology to replication factor C family proteins, conserved from E. coli to human.; Title: strong similarity to Werner helicase interacting protein WHIP - Mus musculus; See PMID 9271578; See PMID 9671747; See PMID 10938117; See PMID 11301316; uncharacterized protein 1350535 4990957 An04g05500 Aspergillus niger uncharacterized protein XP_001401914.1 1348940 D 5061 CDS An04g05510 4990958 join(1351333..1351626,1351707..1351836,1351918..1352213) VI 1 NT_166539.1 Function: the cell division cycle gene CDC31 of S. cerevisiae is required for spindle pole body duplication.; Remark: the calcium-binding CDC31 protein of S. cerevisiae defines a substructure of spindle pole body.; Title: strong similarity to cell division control protein Cdc31 - Saccharomyces cerevisiae; nucleus; See PMID 8408222; See PMID 2839516; uncharacterized protein 1352213 4990958 An04g05510 Aspergillus niger uncharacterized protein XP_059600595.1 1351333 D 5061 CDS An04g05520 84590921 join(1352566..1352702,1352778..1352808) VI 1 NT_166539.1 Title: questionable ORF; uncharacterized protein 1352808 84590921 An04g05520 Aspergillus niger uncharacterized protein XP_059600596.1 1352566 D 5061 CDS An04g05530 4990960 complement(join(1352918..1355223,1355277..1355346)) VI 1 NT_166539.1 Function: the ADAM19 metalloproteinase of H. sapiens belongs to the adamalysin protein family and is involved in proteolysis, adhesion, fusion, and intracellular signaling.; Title: similarity to disintegrin and metalloproteinase ADAM19 - Homo sapiens; cytoplasm; See PMID 10753657; See PMID 11162584; uncharacterized protein 1355346 4990960 An04g05530 Aspergillus niger uncharacterized protein XP_001401917.1 1352918 R 5061 CDS An04g05540 4990961 complement(join(1356268..1357553,1357792..1358170,1358442..1358556,1358689..1358756)) VI 1 NT_166539.1 Remark: the iota polymerase of H. sapiens is able to facilitate limited translesion replication of a thymine-thymine cyclobutane pyrimidine dimer.; Title: strong similarity to DNA polymerase iota POLI - Homo sapiens; nucleus; uncharacterized protein 1358756 4990961 An04g05540 Aspergillus niger uncharacterized protein XP_059600597.1 1356268 R 5061 CDS An04g05550 4990962 1359992..1361176 VI 1 NT_166539.1 Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942; uncharacterized protein 1361176 4990962 An04g05550 Aspergillus niger uncharacterized protein XP_001401919.1 1359992 D 5061 CDS An04g05560 84590922 complement(join(1361768..1361804,1361945..1362015,1362152..1362310,1362404..1362753,1363018..1363250,1363307..1363320)) VI 1 NT_166539.1 Title: similarity to protein fragment SEQ ID NO:1213 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 1363320 84590922 An04g05560 Aspergillus niger uncharacterized protein XP_059600598.1 1361768 R 5061 CDS An04g05570 4990964 join(1363877..1364392,1364632..1365341,1365419..1365893,1365976..1366020) VI 1 NT_166539.1 Similarity: similarities correspond only to the C-terminal region.; Title: similarity to cellular proliferation protein #830 from patent WO200170955-A2 - Staphylococcus aureus; uncharacterized protein 1366020 4990964 An04g05570 Aspergillus niger uncharacterized protein XP_059600599.1 1363877 D 5061 CDS An04g05580 84590923 complement(1366373..>1367677) VI 1 NT_166539.1 Remark: 5'-truncated ORF due to contig-border.; Title: similarity to hypothetical protein B5O22.140 - Neurospora crassa [truncated ORF]; uncharacterized protein 1367677 84590923 An04g05580 Aspergillus niger uncharacterized protein XP_059600600.1 1366373 R 5061 CDS An04g05590 4990966 join(1369261..1369396,1369501..1370306) VI 1 NT_166539.1 Remark: blastp matches are unspecific; Title: weak similarity to hypothetical protein WP6 -Chlamydomonas eugametos; uncharacterized protein 1370306 4990966 An04g05590 Aspergillus niger uncharacterized protein XP_059600601.1 1369261 D 5061 CDS An04g05600 84590924 join(1370476..1370567,1370642..1370791,1370913..1370957,1371002..1371173,1371359..1371426,1371539..1371749,1371902..1371982) VI 1 NT_166539.1 hypothetical protein 1371982 84590924 An04g05600 Aspergillus niger hypothetical protein XP_059600602.1 1370476 D 5061 CDS An04g05610 84590925 complement(join(1372085..1372193,1372254..1372385,1372592..1372708,1372848..1373114,1373279..1373511,1373596..1373772,1373865..1373975,1374080..1374185,1374269..1374587,1374672..1374729)) VI 1 NT_166539.1 hypothetical protein 1374729 84590925 An04g05610 Aspergillus niger hypothetical protein XP_059600603.1 1372085 R 5061 CDS An04g05620 4990969 join(1375046..1375084,1375150..1376394,1376453..1376713,1376774..1376903,1376962..1377236,1377299..1377361) VI 1 NT_166539.1 Catalytic activity: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.; Function: acetate--CoA ligase catalyzes the formation of acetyl-CoA from acetate and CoA.; Induction: by acetate.; Title: strong similarity to acetate--CoA ligase facA - Aspergillus nidulans; see citation in PMID 1972535; see citation in PMID 11255012; uncharacterized protein 1377361 4990969 An04g05620 Aspergillus niger uncharacterized protein XP_001401926.1 1375046 D 5061 CDS An04g05630 4990970 join(1378555..1378639,1378908..1379000,1379309..1383111,1383260..1383539,1383741..1385140,1385201..1385288,1385899..1385920,1386102..1386175,1386329..1386333) VI 1 NT_166539.1 Function: the GLFG region of S. cerevisiae Nup100p directly binds the essential mRNA export factors Mex67 and Gle1.; Function: the GLFG region of S. cerevisiae Nup100p directly binds the protein import factor Kap95p.; Title: similarity to nuclear pore complex subunit Nup100 - Saccharomyces cerevisiae; nucleus; see citation in PMID 8848052; see citation in PMID 1385442; see citation in PMID 10684247; see citation in PMID 11104765; uncharacterized protein 1386333 4990970 An04g05630 Aspergillus niger uncharacterized protein XP_059600604.1 1378555 D 5061 CDS An04g05640 4990971 complement(join(1386708..1387868,1387951..1388022,1388120..1388377)) VI 1 NT_166539.1 Catalytic activity: ubiquinone oxidoreductase converts NADH + ubiquinone to NAD(+) + ubiquinol.; Function: A. niger NUO51 is part of complex I of the mitochondrial respiratory chain.; Gene-ID: nuo51; localisation:mitochondrion; mitochondrial proton-pumping NADH:ubiquinone reductase nuo51-Aspergillus niger 1388377 nuo51 4990971 nuo51 Aspergillus niger mitochondrial proton-pumping NADH:ubiquinone reductase nuo51-Aspergillus niger XP_001401928.1 1386708 R 5061 CDS An04g05650 4990972 complement(join(1388674..1389932,1389985..1390244,1390321..1390679)) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein SPBC1709.13c - Schizosaccharomyces pombe; uncharacterized protein 1390679 4990972 An04g05650 Aspergillus niger uncharacterized protein XP_001401929.3 1388674 R 5061 CDS An04g05660 4990973 complement(join(1391736..1392440,1392916..1393617,1393673..1394590,1394633..1395052,1395112..1395780)) VI 1 NT_166539.1 Complex: S. cerevisae SAP190 physically associates with SIT4, the catalytic subunit of a type 2A-related protein phosphatase.; Function: S. cerevisae SAP190 acts via SIT4, the catalytic subunit of a type 2A-related protein phosphatase.; Function: S. cerevisae SAP190, in redundance with SAP185, is required for bud formation.; Regulation: S. cerevisae SAP190 is not functional in the absence of SIT4 and likewise, SIT4 is not functional in the concomitant absence of SAP190 and SAP185.; Title: strong similarity to bud formation factor Sap190 - Saccharomyces cerevisiae; see citation in PMID 8649382; uncharacterized protein 1395780 4990973 An04g05660 Aspergillus niger uncharacterized protein XP_059600605.1 1391736 R 5061 CDS An04g05670 4990974 join(1397886..1397951,1398066..1398650) VI 1 NT_166539.1 Complex: S. cerevisiae Vps24p and Vps32p/Snf7p form a complex with a Vps4p decamer.; Function: S. cerevisiae Snf7p is involved in endosome to vacuole transport.; Remark: alternative names for S. cerevisiae SNF7 are DID1 and Vps32.; Title: similarity to vacuolar sorting protein Snf7 -Saccharomyces cerevisiae; endosome; see citation in PMID 8224817; see citation in PMID 9606181; see citation in PMID 11251082; uncharacterized protein 1398650 4990974 An04g05670 Aspergillus niger uncharacterized protein XP_001401931.1 1397886 D 5061 CDS An04g05680 4990975 complement(join(1398948..1399758,1399820..1400091,1400152..1400796)) VI 1 NT_166539.1 Function: genetically S. cerevisiae SMF1 is implicated in Cu(2+), Mn(2+), Co(2+) and Cd(2+) homeostasis and, eventually, Fe(2+) uptake.; Function: in Xenopus oocyte assays S. cerevisiae SMF1 mediates H(+)-dependent Fe(2+) transport and uncoupled Na(+), Li(+), Rb(+), K(+) and Ca(2+) flux.; Regulation: S. cerevisiae BSD2 negatively controls metal transport by SMF1, targeting it to the vacuole where it is degraded.; Remark: the PIR entry of S. cerevisiae YOL122c incorrectly contains the gene name ESP1, however, the gene is named SMF1, an alias is SBS1.; Title: strong similarity to metal transporter Smf1 -Saccharomyces cerevisiae; plasma membrane; see citation in PMID 8643535; see citation in PMID 911523; see citation in PMID 10574989; see citation in PMID 10930410; see citation in PMID 11027260; uncharacterized protein 1400796 4990975 An04g05680 Aspergillus niger uncharacterized protein XP_001401932.1 1398948 R 5061 CDS An04g05690 84590926 complement(join(1402301..1402447,1402536..1402620,1402758..1402771,1403226..1403285)) VI 1 NT_166539.1 hypothetical protein 1403285 84590926 An04g05690 Aspergillus niger hypothetical protein XP_059600606.1 1402301 R 5061 CDS An04g05700 4990977 join(1404231..1405274,1405334..1405917,1405971..1406901) VI 1 NT_166539.1 Function: human SRL300 was isolated due to its ability to bind the 5'-noncoding sequence of the ATBF1 mRNA.; Title: similarity to RNA-binding protein SRL300 -Homo sapiens; see citation in PMID 11004489; uncharacterized protein 1406901 4990977 An04g05700 Aspergillus niger uncharacterized protein XP_001401934.1 1404231 D 5061 CDS An04g05710 4990978 complement(join(1407246..1407331,1407430..1407517,1407578..1407639,1407755..1408256)) VI 1 NT_166539.1 Title: weak similarity to hypothetical protein CAE75710.1 - Neurospora crassa; uncharacterized protein 1408256 4990978 An04g05710 Aspergillus niger uncharacterized protein XP_001401935.3 1407246 R 5061 CDS An04g05720 4990979 join(1409114..1409123,1409189..1409639,1409696..1410494) VI 1 NT_166539.1 Catalytic activity: Acetyl-CoA C-acyltransferases convert Acyl-CoA + acetyl-CoA to CoA + 3-oxoacyl-CoA.; Function: Y. lipolytica POT1 is involved in fatty acid utilisation.; Localization: Y. lipolytica POT1 belongs to the peroxisomal rather than the mitochondrial or cytoplasmic class of thiolases.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_3019 and 0468.; Title: strong similarity to peroxisomal acetyl-CoA C-acyltransferase POT1 - Yarrowia lipolytica; peroxisome; see citation in PMID 7916689; uncharacterized protein 1410494 4990979 An04g05720 Aspergillus niger uncharacterized protein XP_001401936.1 1409114 D 5061 CDS An04g05730 4990980 complement(join(1410687..1410866,1410939..1411330,1411398..1411473,1411530..1411583)) VI 1 NT_166539.1 Function: L. pneumophila DotA is one of the factors inhibiting the fusion of the endosome to the lysosome.; Remark: an alternative name for L. pneumophila dotA is dlpA.; Title: similarity to inhibitor of endosome-lysosome fusion DotA - Legionella pneumophila; endosome; see citation in PMID 9632267; see citation in PMID 11207624; uncharacterized protein 1411583 4990980 An04g05730 Aspergillus niger uncharacterized protein XP_001401937.1 1410687 R 5061 CDS An04g05740 4990981 join(1412247..1412641,1412735..1412780,1412836..1413342) VI 1 NT_166539.1 Catalytic activity: arylamine N-acetyltransferase catalyzes the N-acetylation of arylamines by acetyl-CoA.; Function: humna NAT1, together with NAT2,N-acetylates and detoxifies aromatic amines, but also activates their N-hydroxylated metabolites by O- and N,O-acetylation to unstable acetoxy intermediates which decompose to electrophiles, bind to DNA, and lead to mutagensis and carcinogenesis.; Title: similarity to arylamine N-acetyltransferase NAT1 - Homo sapiens; see citation in PMID 2340091; uncharacterized protein 1413342 4990981 An04g05740 Aspergillus niger uncharacterized protein XP_059600607.1 1412247 D 5061 CDS An04g05750 4990982 complement(join(1413529..1413549,1413606..1413700,1413869..1413965,1414037..1414084)) VI 1 NT_166539.1 Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_3194 and Nig024.; Title: strong similarity to hypothetical protein EAA71297.1 - Gibberella zeae [putative sequencing error]; uncharacterized protein 1414084 4990982 An04g05750 Aspergillus niger uncharacterized protein XP_001401939.1 1413529 R 5061 CDS An04g05760 4990983 join(1414747..1415234,1415308..1415387,1415467..1415514,1415582..1418205) VI 1 NT_166539.1 Complex: human HBO1 exists as part of a multisubunit complex that possesses histone H3 and H4 acetyltransferase activities.; Complex: human HBO1 interacts with the androgen receptor (AR), a member of the nuclear receptor superfamily.; Function: HBO1 is part of the histone H3 and H4 acetyltransferase but also specifically repressed androgen receptor mediated transcription.; Similarity: human HBO1 is a member of the MYST domain family; Similarity: similarity is from the central region of the predicted A. niger protein to human HBO1, which is 400 aa shorter.; Title: similarity to histone acetyltransferase HBO1 - Homo sapiens; nucleus; see citation in PMID 10438470; see citation in PMID 10839822; see citation in PMID 10930412; uncharacterized protein 1418205 4990983 An04g05760 Aspergillus niger uncharacterized protein XP_001401940.1 1414747 D 5061 CDS An04g05770 84590927 complement(join(1421052..1421109,1421204..1421300,1421375..1421572,1421703..1421778)) VI 1 NT_166539.1 Title: weak similarity to transcription activator VP1 - Triticum aestivum; see citation in PMID 11413225; uncharacterized protein 1421778 84590927 An04g05770 Aspergillus niger uncharacterized protein XP_059600608.1 1421052 R 5061 CDS An04g05780 84590928 join(1422107..1422172,1422354..1422446,1422864..1422947,1423036..1423183,1423262..1423406,1423468..1423581,1423684..1423745,1423911..1423977,1424060..1424220,1424312..1424380,1424455..1424459) VI 1 NT_166539.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1424459 84590928 An04g05780 Aspergillus niger uncharacterized protein XP_059600609.1 1422107 D 5061 CDS An04g05783 84590929 join(1424585..1424587,1424646..1424733,1424790..1425077,1425182..1425320,1425535..1425591,1425887..1426000,1426271..1426370) VI 1 NT_166539.1 hypothetical protein 1426370 84590929 An04g05783 Aspergillus niger hypothetical protein XP_059600610.1 1424585 D 5061 CDS An04g05790 10098352 join(1427013..1427062,1427152..1427219,1427518..1427607,1427677..1427761,1427955..1428023,1428133..1428460,1428575..1428697,1428765..1428976,1429255..1429348,1429437..1429907,1430004..1432598) VI 1 NT_166539.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Remark: blastp with the predicted A. niger protein only retrieves random hits to serine and glutamine rich proteins.; Title: questionable ORF; uncharacterized protein 1432598 10098352 An04g05790 Aspergillus niger uncharacterized protein XP_059600611.1 1427013 D 5061 CDS An04g05800 4990988 complement(join(1432690..1433528,1434027..1434075)) VI 1 NT_166539.1 Title: similarity to hypothetical protein CAC37374.1 - Schizosaccharomyces pombe; uncharacterized protein 1434075 4990988 An04g05800 Aspergillus niger uncharacterized protein XP_059600612.1 1432690 R 5061 CDS An04g05810 4990989 complement(join(1434102..1436836,1436886..1437789,1437901..1437975)) VI 1 NT_166539.1 Function: S. pombe rad8 mutant is sensitive to both UV and gamma irradiation.; Similarity: S. pombe rad8 is a member of the SNF2 helicase family.; Similarity: similarity is between two regions, each ~ 100 aa, in the N- and C-terminal half of the predicted A. niger protein and S. pombe rad8.; Title: similarity to DNA repair protein rad8p -Schizosaccharomyces pombe; uncharacterized protein 1437975 4990989 An04g05810 Aspergillus niger uncharacterized protein XP_001401946.3 1434102 R 5061 CDS An04g05820 84590930 complement(join(1438797..1440281,1440334..1440479,1440536..1440992)) VI 1 NT_166539.1 Function: C. albicans Rfg1 is a transcriptional regulator controling filamentous growth and virulence.; Similarity: similarity is between regions of ~ 100 aa in the N-terminal halfs of the predicted A. niger protein and C. albicans Rfg1.; Title: similarity to transcription regulator Rfg1 -Candida albicans; see citation in PMID 11259598; uncharacterized protein 1440992 84590930 An04g05820 Aspergillus niger uncharacterized protein XP_059600613.1 1438797 R 5061 CDS An04g05830 84590931 join(1441021..1441050,1441129..1441205,1441443..1441460,1441537..1441631,1441699..1441777,1441858..1441977,1442045..1442093) VI 1 NT_166539.1 Similarity: similarity is between the predicted A. niger protein and the N-terminal half of T. curvata aglA,which is 400 aa longer.; Title: weak similarity to thermotolerant alpha-1,4-glucosidase aglA - Thermomonospora curvata; see citation in PMID 10792537; uncharacterized protein 1442093 84590931 An04g05830 Aspergillus niger uncharacterized protein XP_059600614.1 1441021 D 5061 CDS An04g05840 4990990 complement(join(1444133..1444870,1444927..1445169)) VI 1 NT_166539.1 Title: weak similarity to phospholipid-cholesterol acyltransferase - Aeromonas hydrophila; see citation in PMID 3280033; uncharacterized protein 1445169 4990990 An04g05840 Aspergillus niger uncharacterized protein XP_001401947.3 1444133 R 5061 CDS An04g05850 4990993 join(1447338..1447442,1447579..1447651,1447776..1447796,1447868..1447913,1447972..1448024,1448099..1448417,1448502..1448598) VI 1 NT_166539.1 Remark: S. pombe rps6 is transcribed into three distinct transcripts with different sizes and heterogeneous termini.; Remark: the exon/intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_2975 and 3307 (in the 5'UTR).; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit rps6p - Schizosaccharomyces pombe; cytoplasm; see citation in PMID 2834104; 40S ribosomal protein eS6 1448598 4990993 An04g05850 Aspergillus niger 40S ribosomal protein eS6 XP_001401950.1 1447338 D 5061 CDS An04g05855 84590932 join(1449062..1449127,1449250..1449450) VI 1 NT_166539.1 hypothetical protein 1449450 84590932 An04g05855 Aspergillus niger hypothetical protein XP_059600615.1 1449062 D 5061 CDS An04g05860 4990995 complement(join(1451202..1451628,1451696..1452068,1452141..1452232,1452308..1452378)) VI 1 NT_166539.1 Catalytic activity: ribose-phosphate pyrophosphokinases convert ATP + D-ribose 5-phosphate to AMP + 5-phospho-alpha-D-ribose 1-diphosphate.; Complex: by genetic interaction and two-hybrid PRS family members form functional complexes, e. g. PRS2 with PRS5.; Function: S. cerevisiae phosphoribosyl-pyrophosphate (PRPP) is required for purine, pyrimidine, tryptophan and histidine biosynthesis.; Function: in S. cerevisiae disruption of PRS1 or PRS3 has a significant effect on cell metabolism, whereas disruption of PRS2 or PRS4 has little measurable effect.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger EST an_3596.; Remark: the PRS gene family in S. cerevisiae consists of five genes each capable of encoding a 5-phosphoribosyl-1(alpha)-pyrophosphate synthetase polypeptide.; Title: strong similarity to ribose-phosphate pyrophosphokinase Prs2 - Saccharomyces cerevisiae; see citation in PMID 7992503; see citation in PMID 9108276; see citation in PMID 10212224; uncharacterized protein 1452378 4990995 An04g05860 Aspergillus niger uncharacterized protein XP_001401952.1 1451202 R 5061 CDS An04g05870 4990996 complement(join(1453070..1453164,1453229..1453573,1453639..1457577,1457629..1465408,1465496..1465543)) VI 1 NT_166539.1 Complex: by two-hybrid S. cerevisiae TOM1 interacts with KRR1, which is involved in nucleolar 40S ribosome biogenesis.; Function: S. cerevisiae TOM1 is a E3 ubiquitin ligase involved in hnRNP protein localization and thereby affecting specificity of nuclear mRNA export.; Function: S. cerevisiae strains with mutant alleles of TOM1 are defective in multiple steps in rRNA processing.; Function: in S. cerevisiae, several different hnRNP adaptors for mRNA export exist and TOM1 regulates the localisation of e. g. Nab2p but not Np13p.; Title: strong similarity to E3 ubiquitin ligase Tom1 - Saccharomyces cerevisiae; see citation in PMID 10395901; see citation in PMID 10873801; see citation in PMID 11027267; see citation in PMID 11238398; uncharacterized protein 1465543 4990996 An04g05870 Aspergillus niger uncharacterized protein XP_059600616.1 1453070 R 5061 CDS An04g05880 4990997 complement(join(1466966..1467295,1467380..1467506,1467587..1469765,1469825..1470017,1470072..1470120,1470172..1470269,1470324..1470590)) VI 1 NT_166539.1 Catalytic activity: linoleate diol synthase catalyzes dioxygenation of linoleic acid to (8R)-hydroperoxylinoleate and isomerization of the hydroperoxide to (7S,8S)-dihydroxylinoleate.; Complex: linoleate diol synthase is a homotetrameric ferric hemeprotein.; Function: linoleate diol synthase is involved in the dioxygenation of polyunsaturated fatty acids; Title: strong similarity to linoleate diol synthase - Gaeumannomyces graminis; see citation in PMID 10497176; uncharacterized protein 1470590 4990997 An04g05880 Aspergillus niger uncharacterized protein XP_001401954.1 1466966 R 5061 CDS An04g05900 10098338 complement(1471341..1475753) VI 1 NT_166539.1 Title: strong similarity to reverse transcriptase pol - Volvox carteri; see citation in PMID 7681411; uncharacterized protein 1475753 10098338 An04g05900 Aspergillus niger uncharacterized protein XP_003188676.2 1471341 R 5061 CDS An04g05930 4990999 join(1478092..1478125,1478214..1478429,1478517..1479196) VI 1 NT_166539.1 Complex: S. cerevisiae Tsc13p coimmunoprecipitates with Elo2p and Elo3p, which are also involved in very long chain fatty acid synthesis.; Function: S. cerevisiae TSC13 is required for elongation of the palmitate, produced by cytosolic fatty acid synthase, by two carbon units.; Function: S. cerevisiae TSC13 possibly is the enoyl reductase that catalyzes the last step in each cycle of fatty acid elongation.; Function: S. cerevisiae tsc13 mutant accumulates high levels of long-chain bases as well as ceramides that harbor fatty acids with chain lengths shorter than 26 carbons.; Localization: S. cerevisiae TSC13 localizes to a novel endoplasmic reticulum structure at the nuclear-vacuolar interface.; Title: strong similarity to very long chain fatty acid synthase Tsc13 - Saccharomyces cerevisiae; endoplasmatic reticulum; see citation in PMID 11113186; uncharacterized protein 1479196 4990999 An04g05930 Aspergillus niger uncharacterized protein XP_001401956.1 1478092 D 5061 CDS An04g05940 4991000 complement(join(1479755..1479985,1480160..1480593,1480666..1480957)) VI 1 NT_166539.1 Function: gma12p is not the only galactosyltransferase in S. pombe, but it produces a unique carbohydrate structure on the surface of the yeast cells.; Golgi; Localization: electron microscopic localization revealed that gma12p synthesizes the carbohydrate structure in the Golgi apparatus.; Title: strong similarity to alpha 1,2 galactosyltransferase gma12p - Schizosaccharomyces pombe; see citation in PMID 7522655; uncharacterized protein 1480957 4991000 An04g05940 Aspergillus niger uncharacterized protein XP_001401957.1 1479755 R 5061 CDS An04g05950 4991001 complement(1481771..1482670) VI 1 NT_166539.1 Remark: alternative names for S. cerevisiae MRPL24 are YML14, YML24 and YMR193W.; Remark: of the ~50 MRPs isolated in S. cerevisiae (until 1998) only a minority show significant sequence similarities to known ribosomal proteins from other sources.; Similarity: the predicted A. niger protein is 80 aa longer than S. cerevisiae MRPL24 and might use a wrong startcodon.; Title: strong similarity to mitochondrial ribosomal protein of the large subunit L24 - Saccharomyces cerevisiae; localisation:mitochondrion; see citation in PMID 9151978; see citation in PMID 9445368; mitochondrial 54S ribosomal protein bL28m 1482670 4991001 An04g05950 Aspergillus niger mitochondrial 54S ribosomal protein bL28m XP_001401958.3 1481771 R 5061 CDS An04g05960 4991002 join(1482798..1482941,1483024..1483243,1483302..1483849,1483910..1484374) VI 1 NT_166539.1 Complex: rat TIP49a binds to TIP49b, which is a 5' to 3' DNA-helicase, TBP and RNA-pol II.; Function: rat TIP49a ATPase activity is stimulated by single-stranded DNA but neither by double-stranded DNA nor by any forms of RNA polymers tested.; Function: rat TIP49a is a DNA-helicase unwounding dsDNA in the 3' to 5' direction with respect to the single-stranded DNA flanking the duplex.; Title: strong similarity to DNA-helicase TIP49a -Rattus norvegicus; nucleus; see citation in PMID 9196036; see citation in PMID 10336418; see citation in PMID 10428817; see citation in PMID 10787406; uncharacterized protein 1484374 4991002 An04g05960 Aspergillus niger uncharacterized protein XP_001401959.1 1482798 D 5061 CDS An04g05970 4991003 complement(join(1484687..1485331,1485381..1486090,1486164..1486377)) VI 1 NT_166539.1 Function: the cyclopropane synthase from Sterculia foetida produces dihydrosterculate from oleate and uses S-adenosylmethionine as the methylene donor.; Similarity: the predicted A. niger protein contains FAD- and NADH-binding motifs of pyridine nucleotide-disulphide deoxygenases.; Title: similarity to cyclopropane synthase AAM33848.1 - Sterculia foetida; see citation in PMID 11997456; uncharacterized protein 1486377 4991003 An04g05970 Aspergillus niger uncharacterized protein XP_059600617.1 1484687 R 5061 CDS An04g05980 4991004 join(1487584..1487763,1487831..1488237,1488321..1488408) VI 1 NT_166539.1 Complex: S. cerevisiae Vti1p interacts with the t-SNAREs Sed5p, Pep12p, Vam3p and Vam7p, the v-SNAREs Nyv1p and Ykt6p and the SNAP Sec17p.; Function: S. cerevisiae Vti1p acts as a retrograde v-SNARE and interacts directly with the t-SNARE Sed5p to target retrograde vacuole to cis-Golgi traffic.; Function: in S. cerevisiae the transport vesicle specivic v-SNARE Vti1p interacts with the prevacuolar target specific t-SNARE Pep12p to direct Golgi to prevacuolar traffic.; Function: in S. cerevisiae vacuole-vacuole fusion requires a cis-SNARE complex of five SNAREs, the t-SNAREs Vam3p and Vam7p and the v-SNAREs Nyv1p, Vti1p, and Ykt6p.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_2635, 2436 and 2514.; Title: strong similarity to v-SNARE Vti1 -Saccharomyces cerevisiae; intracellular transport vesicles; see citation in PMID 9199167; see citation in PMID 9398683; see citation in PMID 10385523; uncharacterized protein 1488408 4991004 An04g05980 Aspergillus niger uncharacterized protein XP_001401961.1 1487584 D 5061 CDS An04g05990 4991005 complement(1488670..1489674) VI 1 NT_166539.1 Title: similarity to hypothetical protein B23I11.280 - Neurospora crassa; uncharacterized protein 1489674 4991005 An04g05990 Aspergillus niger uncharacterized protein XP_059600618.1 1488670 R 5061 CDS An04g06000 4991006 join(1491361..1491401,1491641..1491729,1491788..1491895,1491963..1492501,1492562..1492835,1492960..1493060,1493111..1493297,1493348..1493811) VI 1 NT_166539.1 Function: S. cerevisiae PUT3 is a positive regulator of PUT (proline utilization) genes.; Similarity: S. cerevisiae PUT3 is a zinc finger transcription factor with a fungal GAL4-type Zn(2)-Cys(6) binuclear cluster domain.; Similarity: similarity is between the predicted A. niger protein and the C-terminal 2/3s of S. cerevisiae PUT3, which is 300 aa longer.; Title: similarity to transcription activator Put3 -Saccharomyces cerevisiae; nucleus; see citation in PMID 2689861; uncharacterized protein 1493811 4991006 An04g06000 Aspergillus niger uncharacterized protein XP_059600619.1 1491361 D 5061 CDS An04g06010 4991007 join(1494312..1494990,1495097..1495386) VI 1 NT_166539.1 Title: similarity to mitomycin biosynthesis protein MmcH from patent WO200053737-A2 - Streptomyces lavendulae; uncharacterized protein 1495386 4991007 An04g06010 Aspergillus niger uncharacterized protein XP_001401964.1 1494312 D 5061 CDS An04g06020 4991008 complement(join(1496312..1496349,1496411..1497116)) VI 1 NT_166539.1 Function: S. cerevisiae ISA1 is involved in the assembly of Fe/S-clusters in mitochondrial and cytoplasmatic proteins.; Localization: S. cerevisiae ISA1 localises to the mitochondrial matrix.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger EST an_3349 .; Title: strong similarity to mediator of mitochondrial Fe/S-cluster assembly Isa1 - Saccharomyces cerevisiae; localisation:mitochondrion; see citation in PMID 10748136; see citation in PMID 10805735; see citation in PMID 10913600; uncharacterized protein 1497116 4991008 An04g06020 Aspergillus niger uncharacterized protein XP_001401965.1 1496312 R 5061 CDS An04g06030 4991009 join(1498326..1498406,1498467..1498589,1498648..1498728,1498797..1498932,1498986..1499098,1499158..1499492,1499544..1499954,1500011..1500674) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein SPBC20F10.02c - Schizosaccharomyces pombe; uncharacterized protein 1500674 4991009 An04g06030 Aspergillus niger uncharacterized protein XP_059600620.1 1498326 D 5061 CDS An04g06040 4991010 complement(join(1501092..1501303,1501357..1501741,1501855..1502086,1502292..1502455)) VI 1 NT_166539.1 Function: S. cerevisiae EAF3 is component of the NuA4 histone-acetyltransferase complex, however eaf3 mutations are viable and have no growth phenotype.; Function: S. pombe alp13 mutants are temperature-sensitive, have cell polarity defects and are sterile.; Remark: a splice site was detected upstream of the START codon.; Similarity: the predicted A. niger protein shows strong similarity to alp13 of S. pombe (also known as chromo domain protein), which belongs to the MRG protein family. MRG proteins comprise the homologous proteins human MORF4 related gene, D. melanogaster male specific lethal-3 (Msl-3) and S. cerevisiae Eaf3p.; Title: strong similarity to cell polarity determinant alp13p - Schizosaccharomyces pombe; see citation in PMID 9658169; see citation in PMID 11036083; uncharacterized protein 1502455 4991010 An04g06040 Aspergillus niger uncharacterized protein XP_001401967.1 1501092 R 5061 CDS An04g06050 4991011 1503412..1503993 VI 1 NT_166539.1 Title: strong similarity to hypothetical protein SPAC23H4.11c - Schizosaccharomyces pombe; uncharacterized protein 1503993 4991011 An04g06050 Aspergillus niger uncharacterized protein XP_001401968.1 1503412 D 5061 CDS An04g06060 4991012 join(1504797..1505253,1505285..1505637) VI 1 NT_166539.1 Complex: S. cerevisiae Ctf8p interact physically with Ctf18p, Dcc1p, Rfc2p, Rfc3p, Rfc4p and Rfc5p but not with Rfc1p or Rad24p.; Function: S. cerevisiae Ctf8p forms part of an alternative replication factor complex (RFC) involved in sister chromatid cohesion and faithful chromosome transmission.; Function: deletion of S. cerevisiae CTF8 leads to a severe sister chromatid cohesion defect.; Remark: the systematic name for S. cerevisiae CTF8 is YHR191c.; Title: similarity to replication factor complex subunit Ctf8 - Saccharomyces cerevisiae; nucleus; see citation in PMID 11389843; uncharacterized protein 1505637 4991012 An04g06060 Aspergillus niger uncharacterized protein XP_059600621.1 1504797 D 5061 CDS An04g06070 4991013 join(1506902..1507003,1507103..1507315) VI 1 NT_166539.1 Title: strong similarity to EST an_1548 -Aspergillus niger; uncharacterized protein 1507315 4991013 An04g06070 Aspergillus niger uncharacterized protein XP_001401970.1 1506902 D 5061 CDS An04g06080 4991014 complement(join(1507790..1507852,1507908..1508377,1508414..1508849,1508916..1509085,1509293..1510469,1510533..1510565)) VI 1 NT_166539.1 Complex: human GAPCenA interacts with Rab6,cytosolic gamma-tubulins and is associated with the centrosome.; Function: human GAPCenA is a GAP specifically active in vitro on Rab6, which regulates intracellular transport at the level of the Golgi, and, to a lesser extent, on Rab4 and Rab2 proteins.; Function: human GAPCenA may be involved in the coordination of microtubule and Golgi dynamics during the cell cycle.; Function: human GAPCenA was found to form complexes with cytosolic gamma-tubulin and to play a role in microtubule nucleation.; Localization: immunofluorescence and cell fractionation experiments showed that human GAPCenA is mainly cytosolic but that a minor pool is associated with the centrosome.; Title: similarity to Rab6 GTPase activating protein GAPCenA - Homo sapiens; see citation in PMID 10202141; uncharacterized protein 1510565 4991014 An04g06080 Aspergillus niger uncharacterized protein XP_059600622.1 1507790 R 5061 CDS An04g06090 4991015 complement(join(1511807..1512136,1512156..1512845,1512968..1513012)) VI 1 NT_166539.1 Function: S. cerevisiae BET4 is required for the prenylation of Rab GTP-binding proteins which leads to their membrane attachment and subsequent activity in the regulation of vesicular traffic.; Title: similarity to geranylgeranyltransferase type-II alpha chain Bet4 - Saccharomyces cerevisiae; see citation in PMID 8756702; uncharacterized protein 1513012 4991015 An04g06090 Aspergillus niger uncharacterized protein XP_059600623.1 1511807 R 5061 CDS An04g06100 4991016 join(1513516..1514548,1514791..1515493,1515713..1516430) VI 1 NT_166539.1 Complex: human CDC20 binds to APC, a hMAD2 tetramer,cyclin A, BUBR1 and the kinase aurora2/Aik.; Function: activation of the anaphase-promoting complex (APC) by binding of human CDC20 in metaphase and CDH1 in telophase is required for anaphase and for exit from mitosis.; Function: the human checkpoint protein hMAD2 prevents activation of APC by forming a hMAD2-CDC20-APC complex.; Regulation: the phosphorylation of Cdc20 by Cdc2-Cyclin B and cyclinA-cyclin A-associated kinase influences activity of the CDC20-APC complex.; Remark: an alternative name for human CDC20 is p55CDC.; Similarity: similarity is from the central region of the predicted A. niger protein to human CDC20, which is 400 aa shorter.; Title: similarity to cell cycle protein CDC20 - Homo sapiens; nucleus; see citation in PMID 7513050; see citation in PMID 9637688; see citation in PMID 10377410; see citation in PMID 10459014; see citation in PMID 10679238; uncharacterized protein 1516430 4991016 An04g06100 Aspergillus niger uncharacterized protein XP_059600624.1 1513516 D 5061 CDS An04g06110 4991017 join(1516908..1517221,1517365..1517476,1517654..1517670,1517834..1517864,1517960..1517974) VI 1 NT_166539.1 Remark: blastp with the predicted A. niger protein only retrieves random hits to threonine rich proteins.; hypothetical protein 1517974 4991017 An04g06110 Aspergillus niger hypothetical protein XP_001401974.3 1516908 D 5061 CDS An04g06120 4991018 complement(join(1518271..1520254,1520313..1520878)) VI 1 NT_166539.1 Similarity: the ORF shows also strong similarity to EST EMBLEST:BE759148 an_3476 from Aspergillus niger.; Title: strong similarity to hypothetical protein YDR398w - Saccharomyces cerevisiae; uncharacterized protein 1520878 4991018 An04g06120 Aspergillus niger uncharacterized protein XP_001401975.1 1518271 R 5061 CDS An04g06130 84590933 complement(join(1522179..1522252,1522302..1522407,1522482..1522872,1523050..1523363,1523476..1523526)) VI 1 NT_166539.1 Title: weak similarity to transcription factor SoxP1 - Oncorhynchus mykiss; see citation in PMID 8543013; uncharacterized protein 1523526 84590933 An04g06130 Aspergillus niger uncharacterized protein XP_059600625.1 1522179 R 5061 CDS An04g06140 4991020 join(1523739..1523842,1523901..1524969,1525006..1525021,1525112..1525971,1526030..1526362) VI 1 NT_166539.1 Function: S. cerevisiae BDF1 is transcription factor involved in control of snRNA expression.; Function: in S. cerevisiae most cells from the bdf1 null mutant fail to undergo one or both meiotic divisions,and there is an absolute defect in spore formation.; Similarity: S. cerevisiae BDF1 contains two bromodomains.; Title: similarity to transcription factor Bdf1 -Saccharomyces cerevisiae; nucleus; see citation in PMID 7791775; see citation in PMID 7816623; uncharacterized protein 1526362 4991020 An04g06140 Aspergillus niger uncharacterized protein XP_059600626.1 1523739 D 5061 CDS An04g06150 4991021 join(1527024..1527167,1527248..1527346,1527415..1527977,1528048..1528273,1528497..1528787,1528876..1528938) VI 1 NT_166539.1 Function: S. cerevisiae DPH gene products catalyse the post translational modification of a histidine residue in translation elongation factor-2 (EF-2) to a diphthamide residue.; Similarity: similarity is from the C-terminal region of the predicted A. niger protein to the N-terminal region of S. cerevisiae DPH3.; Title: weak similarity to DPH3 from patent WO9953762-A1 - Saccharomyces cerevisiae; uncharacterized protein 1528938 4991021 An04g06150 Aspergillus niger uncharacterized protein XP_001401978.3 1527024 D 5061 CDS An04g06160 4991022 complement(join(1529549..1529824,1529918..1530286)) VI 1 NT_166539.1 Function: S. cerevisiae frataxin (YFH1) is necessary for FeS cluster assembly into ferredoxin.; Function: S. cerevisiae yfh1 mutations are highly sensitive to oxidants, such as H2O2, iron and copper and their mitochondria contain 10 times more iron than wild-type.; Function: expansion of GAA repeats in human frataxin causes Friedreich's ataxia, an autosomal recessive,degenerative disease of central and peripheral nervous systems and the heart.; Title: strong similarity to mitochondrial frataxin Yfh1 - Saccharomyces cerevisiae; localisation:mitochondrion; see citation in PMID 8596916; see citation in PMID 9241270; see citation in PMID 9271239; see citation in PMID 11273703; uncharacterized protein 1530286 4991022 An04g06160 Aspergillus niger uncharacterized protein XP_001401979.3 1529549 R 5061 CDS An04g06170 4991023 join(1530717..1531268,1531350..1531916) VI 1 NT_166539.1 Title: similarity to hypothetical protein B7N4.10 -Neurospora crassa; uncharacterized protein 1531916 4991023 An04g06170 Aspergillus niger uncharacterized protein XP_059600627.1 1530717 D 5061 CDS An04g06180 4991024 complement(1532062..1534335) VI 1 NT_166539.1 Complex: Sec6p of S. cerevisiae and six other proteins (Sec15p, Sec8p, Sec3p, Sec5p, Sec10p and Exo70p) together form the exocyst complex.; Function: S. cerevisiae Sec6 is a cytoplasmic protein involved in the last step of the secretory pathway,the fusion of post-Golgi vesicles with the plasma membrane.; Function: S. cerevisiae Sec6 is a subunit of the Exocyst complex, which is required for exocytosis.; Localization: the exocyst of S. cerevisiae is found in the cytoplasm and associated with the plasma membrane,where it is specifically located at sites of vesicle fusion.; Title: strong similarity to exocyst subunit Sec6 -Saccharomyces cerevisiae; plasma membrane; see citation in PMID 7615633; see citation in PMID 8978675; see citation in PMID 10203793; see citation in PMID 1523887; see citation in PMID 10873817; uncharacterized protein 1534335 4991024 An04g06180 Aspergillus niger uncharacterized protein XP_001401981.1 1532062 R 5061 CDS An04g06190 4991025 1534976..1535263 VI 1 NT_166539.1 Remark: an alternative name for S. cerevisiae MRPL33 is YML33.; Title: strong similarity to mitochondrial ribosomal protein of the large subunit L30 - Saccharomyces cerevisiae; localisation:mitochondrion; see citation in PMID 2061283; mitochondrial 54S ribosomal protein uL30m 1535263 4991025 An04g06190 Aspergillus niger mitochondrial 54S ribosomal protein uL30m XP_001401982.1 1534976 D 5061 CDS An04g06200 4991026 complement(join(1535804..1536815,1536867..1537000,1537049..1537526,1537647..1537933)) VI 1 NT_166539.1 Function: S. cerevisae DPL1 is required for the breakdown of long-chain-base phosphates like sphingosine-1-phosphate (PHS-1-P) and dihydrosphingosine-1-phosphate (DHS-1-P), which have been implicated as signaling molecules specifically stimulating a calcium-signaling mechanism.; Function: S. cerevisae dpl1delta deletion mutant,which accumulates endogenous phosphorylated sphingoid bases, exhibit unregulated proliferation upon approach to stationary phase.; Title: strong similarity to dihydrosphingosine/sphingosine phosphate lyase Dpl1 -Saccharomyces cerevisiae; see citation in PMID 9973338; see citation in PMID 10329480; see citation in PMID 11278643; uncharacterized protein 1537933 4991026 An04g06200 Aspergillus niger uncharacterized protein XP_001401983.3 1535804 R 5061 CDS An04g06210 4991027 complement(join(1538451..1539402,1539462..1539529,1539586..1539666,1539730..1539959,1540022..1540088)) VI 1 NT_166539.1 Catalytic activity: homocitrate synthases convert 2-hydroxybutane-1,2,4-tricarboxylate + CoA to acetyl-CoA + H(2)O + 2-oxoglutarate.; Function: P. chrysogenum lys1 catalyzes the first step of the lysine and penicillin pathway.; Title: strong similarity to homocitrate synthase lys1 - Penicillium chrysogenum; see citation in PMID 9889317; uncharacterized protein 1540088 4991027 An04g06210 Aspergillus niger uncharacterized protein XP_001401984.1 1538451 R 5061 CDS An04g06220 84590934 join(1540392..1540553,1540619..1540741,1541146..1541238,1541405..1541428) VI 1 NT_166539.1 hypothetical protein 1541428 84590934 An04g06220 Aspergillus niger hypothetical protein XP_059600628.1 1540392 D 5061 CDS An04g06230 84590935 join(1545551..1545683,1545884..1545977,1546158..1546242) VI 1 NT_166539.1 hypothetical protein 1546242 84590935 An04g06230 Aspergillus niger hypothetical protein XP_059600629.1 1545551 D 5061 CDS An04g06240 4991030 join(1547953..1548242,1548455..1549241,1549295..1550194) VI 1 NT_166539.1 Function: TRI10 of F. sporotrichioides controls expression of trichothecene toxin synthesis genes.; Phenotype: disruption of TRI10 in F. sporotrichioides abolished T-2 toxin production and dramatically decreased the transcript accumulation for four trichothecene genes (Tri4, Tri5, Tri6, and Tri101) and an apparent farnesyl pyrophosphate synthetase (Fpps) gene.; Remark: disruption of TRI10 additionally increased sensitivity to T-2 toxin under certain growth conditions.; Remark: trichothecenes are sesquiterpenoid mycotoxins and act as protein synthesis inhibitors for eukaryotic organisms.; Title: similarity to transcription regulator TRI10 -Fusarium sporotrichioides; see citation in PMID 11679358; uncharacterized protein 1550194 4991030 An04g06240 Aspergillus niger uncharacterized protein XP_059600630.1 1547953 D 5061 CDS An04g06250 4991031 1551014..1552693 VI 1 NT_166539.1 Function: it has been proposed that C. carbonum TOXA encodes an HC-toxin efflux pump which contributes to self-protection against HC-toxin and/or the secretion of HC-toxin into the extracellular milieu.; Remark: the predicted A. niger protein occurs from a genomic region containing a peptide synthase biosynthesis.; Similarity: C. carbonum TOXA is a member of the major facilitator superfamily.; Title: strong similarity to HC-toxin efflux pump TOXA - Cochliobolus carbonum; plasma membrane; see citation in PMID 8704997; uncharacterized protein 1552693 4991031 An04g06250 Aspergillus niger uncharacterized protein XP_001401988.1 1551014 D 5061 CDS An04g06260 4991032 join(1553436..1559179,1559350..1560187) VI 1 NT_166539.1 Function: B. brevis TycC is composed of six modules that each incorporate one amino acid into the peptide product.; Similarity: the predicted A. niger protein shows modular repetetive similarity to B. brevis TycC, which is 3500 aa longer.; Title: strong similarity to peptide synthase TycC -Bacillus brevis; see citation in PMID 9352938; uncharacterized protein 1560187 4991032 An04g06260 Aspergillus niger uncharacterized protein XP_001401989.3 1553436 D 5061 CDS An04g06270 4991033 complement(join(1560777..1560804,1561140..1561267,1561449..1561597,1561671..1561924,1561991..1562166)) VI 1 NT_166539.1 Title: similarity to hypothetical methyltransferase AAO27746.2 - Fusarium sporotrichioides; uncharacterized protein 1562166 4991033 An04g06270 Aspergillus niger uncharacterized protein XP_001401990.3 1560777 R 5061 CDS An04g06280 4991034 1562809..1563435 VI 1 NT_166539.1 Title: strong similarity to hypothetical protein BAC47520.1 - Bradyrhizobium japonicum; uncharacterized protein 1563435 4991034 An04g06280 Aspergillus niger uncharacterized protein XP_001401991.1 1562809 D 5061 CDS An04g06290 4991035 complement(join(1563613..1564179,1564230..1564665,1564740..1564903)) VI 1 NT_166539.1 Similarity: similarity is from the predicted A. niger protein to the central region of S. pombe zas1, which is 500 aa longer.; Similarity: the predicted A. niger protein contains a fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain.; Title: weak similarity to C2H2 zinc finger protein zas1p - Schizosaccharomyces pombe; uncharacterized protein 1564903 4991035 An04g06290 Aspergillus niger uncharacterized protein XP_001401992.1 1563613 R 5061 CDS An04g06300 4991036 complement(join(1565318..1566099,1566150..1566273)) VI 1 NT_166539.1 Title: similarity to hypothetical protein CAE76440.1 - Neurospora crassa; uncharacterized protein 1566273 4991036 An04g06300 Aspergillus niger uncharacterized protein XP_001401993.3 1565318 R 5061 CDS An04g06310 4991037 join(1567155..1567478,1567555..1567952,1568015..1568066) VI 1 NT_166539.1 Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to hypothetical protein CAB91735.2 - Neurospora crassa; uncharacterized protein 1568066 4991037 An04g06310 Aspergillus niger uncharacterized protein XP_001401994.1 1567155 D 5061 CDS An04g06320 4991038 join(1568452..1568767,1568853..1569184) VI 1 NT_166539.1 Similarity: the ORF shows also strong similarity to EST 3917 of patent WO200056762-A2 from A. niger.; Title: strong similarity to hypothetical protein SPAC19A8.14 - Schizosaccharomyces pombe; uncharacterized protein 1569184 4991038 An04g06320 Aspergillus niger uncharacterized protein XP_059600631.1 1568452 D 5061 CDS An04g06330 4991039 complement(join(1569759..1570234,1570297..1570788,1570856..1570922)) VI 1 NT_166539.1 Complex: N. crassa NMR interacts via specific protein-protein binding with two distinct regions of NIT2.; Function: N. crassa NMR is a repressor of nitrogen metabolismus, acting via inhibition of transcriptional activation by NIT2.; Title: similarity to repressor of nitrogen metabolism NMR - Neurospora crassa; see citation in PMID 9427402; uncharacterized protein 1570922 4991039 An04g06330 Aspergillus niger uncharacterized protein XP_001401996.1 1569759 R 5061 CDS An04g06340 4991040 join(1571550..1571726,1571784..1572071) VI 1 NT_166539.1 Similarity: the ORF shows strong similarity to the A. niger protein An12g01370. The ORF, however, is much shorter than An12g01370 (154 compared to 667 amino acids).; Title: strong similarity to hypothetical protein encoded by An12g01370 - Aspergillus niger; uncharacterized protein 1572071 4991040 An04g06340 Aspergillus niger uncharacterized protein XP_001401997.1 1571550 D 5061 CDS An04g06350 4991041 join(1574351..1574771,1574844..1575424) VI 1 NT_166539.1 Catalytic activity: dihydrokaempferol 4-reductases convert to Cis-3,4-leucopelargonidin + NADP(+) to (+)-dihydrokaempferol + NADPH.; Function: P. hybrida DFR is involved in flavonoid-biosynthetis.; Title: similarity to dihydroflavenol 4-reductase DFR - Petunia hybrida; see citation in PMID 2491667; uncharacterized protein 1575424 4991041 An04g06350 Aspergillus niger uncharacterized protein XP_001401998.1 1574351 D 5061 CDS An04g06360 84590936 complement(1575733..1575933) VI 1 NT_166539.1 Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1575933 84590936 An04g06360 Aspergillus niger uncharacterized protein XP_059600632.1 1575733 R 5061 CDS An04g06367 84590937 complement(1576622..1577086) VI 1 NT_166539.1 hypothetical protein 1577086 84590937 An04g06367 Aspergillus niger hypothetical protein XP_059600633.1 1576622 R 5061 CDS An04g06370 4991044 join(1578043..1580046,1580224..1580297,1580384..1580420) VI 1 NT_166539.1 Function: the mouse homologe of T. nigroviridis SART1, Haf, is a DNA-binding factor involved in transcriptional activation induced by hypoxia.; Title: similarity to hypoxia-associated transcriptional activator SART1 - Tetraodon nigroviridis; see citation in PMID 10887110; see citation in PMID 11410364; uncharacterized protein 1580420 4991044 An04g06370 Aspergillus niger uncharacterized protein XP_001402001.3 1578043 D 5061 CDS An04g06380 4991045 join(1581290..1581409,1581473..1581551,1581663..1582303,1582358..1582645,1582695..1582754,1582803..1582904) VI 1 NT_166539.1 Catalytic activity: aspartate aminotransferases convert L-aspartate + 2-oxoglutarate to oxaloacetate + L-glutamate.; Function: aspartate aminotransferases are involved in amino acid and nitrogen metabolism.; Localization: there are two aspartate aminotransferase isozymes in M. musculus, one is located in the mitochondrion and one in the cytoplasm.; Title: strong similarity to mitochondrial aspartate aminotransferase mAspAT - Mus musculus; see citation in PMID 2828632; see citation in PMID 3782150; see citation in PMID 6859879; uncharacterized protein 1582904 4991045 An04g06380 Aspergillus niger uncharacterized protein XP_001402002.1 1581290 D 5061 CDS An04g06390 84590938 complement(join(1585641..1585805,1586064..1586171,1586385..1586508,1586621..1586719,1586803..1586854,1586995..1587034)) VI 1 NT_166539.1 Title: questionable ORF; uncharacterized protein 1587034 84590938 An04g06390 Aspergillus niger uncharacterized protein XP_059603600.1 1585641 R 5061 CDS An04g06400 4991047 join(1588209..1588289,1588855..1589031,1589265..1589320,1589561..1589721,1590555..1592896) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein CAE76455.1 - Neurospora crassa; uncharacterized protein 1592896 4991047 An04g06400 Aspergillus niger uncharacterized protein XP_001402004.3 1588209 D 5061 CDS An04g06410 84590939 join(1593344..1593412,1593464..1593637) VI 1 NT_166539.1 Remark: the patent database entry is an amino acid sequence derived by conceptual translation from RT-PCR DNA.; Title: weak similarity to protein fragment SEQ ID NO:30180 from patent EP1033405-A2 - Zea mays; uncharacterized protein 1593637 84590939 An04g06410 Aspergillus niger uncharacterized protein XP_059603601.1 1593344 D 5061 CDS An04g06420 4991049 join(1595289..1595339,1595429..1595591,1595673..1595826,1595968..1596332,1596384..1596935,1596989..1597174,1597227..1597468) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein SPAC12G12.14 - Schizosaccharomyces pombe; uncharacterized protein 1597468 4991049 An04g06420 Aspergillus niger uncharacterized protein XP_059603602.1 1595289 D 5061 CDS An04g06430 4991050 complement(join(1598866..1599630,1599681..1599820,1599872..1600247)) VI 1 NT_166539.1 Function: zinc finger-containing proteins are usually transcription regulators, and the domain is directly involved in DNA binding.; Remark: the C2H2 zinc finger is composed of two short beta strands followed by an alpha helix; the amino terminal part of the helix binds the major groove in DNA binding zinc fingers.; Similarity: The C2H2 zinc finger is the classical zinc finger domain, where the two conserved cysteines and histidines co-ordinate a zinc ion.; Similarity: the similarity to BMZF3 of H. sapiens is due to the presence of four zinc fingers in the predicted ORFs; similarly, the predicted ORF shows similarity to many other putative zinc finger proteins.; Title: similarity to zinc finger protein BMZF3 from patent WO9962951-A1 - Homo sapiens; uncharacterized protein 1600247 4991050 An04g06430 Aspergillus niger uncharacterized protein XP_001402007.3 1598866 R 5061 CDS An04g06440 84590940 join(1600288..1600391,1600445..1600594,1600694..1600745,1600878..1601090,1601193..1601276) VI 1 NT_166539.1 hypothetical protein 1601276 84590940 An04g06440 Aspergillus niger hypothetical protein XP_059603603.1 1600288 D 5061 CDS An04g06450 84590941 join(1601583..1601934,1602148..1602152,1602557..1602663,1602860..1603253,1603333..1603381,1603411..1603595) VI 1 NT_166539.1 Title: questionable ORF; uncharacterized protein 1603595 84590941 An04g06450 Aspergillus niger uncharacterized protein XP_059603604.1 1601583 D 5061 CDS An04g06460 84590942 join(1604105..1604132,1604230..1605065) VI 1 NT_166539.1 hypothetical protein 1605065 84590942 An04g06460 Aspergillus niger hypothetical protein XP_059603605.1 1604105 D 5061 CDS An04g06470 84590943 join(1605140..1605191,1605276..1605345,1605450..1605533,1605608..1605883,1605990..1606167) VI 1 NT_166539.1 hypothetical protein 1606167 84590943 An04g06470 Aspergillus niger hypothetical protein XP_059603606.1 1605140 D 5061 CDS An04g06480 84590944 complement(join(1607258..1607422,1607517..1607555)) VI 1 NT_166539.1 hypothetical protein 1607555 84590944 An04g06480 Aspergillus niger hypothetical protein XP_059603607.1 1607258 R 5061 CDS An04g06490 4991056 join(1607833..1608167,1608222..1608837) VI 1 NT_166539.1 Catalytic activity: DHHB-MT catalyzes the reaction: S-Adenosyl-L-methionine + 3-Hexaprenyl-4,5-dihydroxybenzoate = S-Adenosyl-L-homocysteine + 3-Hexaprenyl-4-hydroxy-5-methoxybenzoate.; Localization: in S. cerevisiae the COQ3 gene product, DHHB-MT, is a mitochondrial protein.; Pathway: this reaction is the fourth step in the biosynthesis of ubiquinone (coenzyme Q) from p-hydroxybenzoic acid.; Similarity: the 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase (DHHB-MT) of R. norvegicus is very similar to the yeast homologue COQ3, and can complement COQ3 mutations in S. cerevisiae.; Title: strong similarity to 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase - Rattus norvegicus; See PMID 9932649; See PMID 8125303; uncharacterized protein 1608837 4991056 An04g06490 Aspergillus niger uncharacterized protein XP_059603608.1 1607833 D 5061 CDS An04g06500 4991057 complement(join(1609126..1610161,1610279..1610343,1610409..1611314)) VI 1 NT_166539.1 Function: BRAP2 of H. sapiens binds to the nuclear localization signal of the tumor suppressor gene BRCA1.; Localization: as human BRAP2 is mainly localized in the cytoplasm, its proposed function is to be a cytoplasmic retention protein for BRCA1, thus regulating its transcriptional activity.; Similarity: as for human BRAP2, the main structural feature of the predicted ORF is to contain zinc fingers and leucine zippers in the middle and C-terminal regions of the protein, respectively.; Title: strong similarity to BRCA1-associated protein 2 BRAP2 - Homo sapiens; See PMID 9497340; See PMID 10819535; uncharacterized protein 1611314 4991057 An04g06500 Aspergillus niger uncharacterized protein XP_059603609.1 1609126 R 5061 CDS An04g06510 4991058 complement(join(1611850..1612529,1612603..1612818,1612889..1612910)) VI 1 NT_166539.1 Function: ubiquitin is involved in the ATP-dependent selective degradation of cellular proteins, the maintenance of chromatin structure, the regulation of gene expression, the stress response, ribosome biogenesis and intracellular sorting of membrane proteins.; Similarity: an A. niger EST corresponding to part of the predicted ORF has been patented under patentnumber WO200056762-A2.; Similarity: the predicted ORF is constituted by four ubiquitin units, the only differences with the S. cerevisiae homologue UBI4 being that the yeast gene contains five ubiquitin units and that, at position 28 of the ubiquitin unit, the predicted ORF shows a conservative substitution Ser > Thr.; Title: strong similarity to polyubiquitin 5 Ubi4 -Saccharomyces cerevisiae; cytoplasm; See PMID 8657109; See PMID 8922277; See PMID 8982460; See PMID 3038523; See PMID 7721857; uncharacterized protein 1612910 4991058 An04g06510 Aspergillus niger uncharacterized protein XP_001402015.1 1611850 R 5061 CDS An04g06520 84590945 join(1613435..1613456,1613578..1613709,1613789..1613956,1614086..1614155,1614238..1614318,1614402..1614515,1614606..1614759) VI 1 NT_166539.1 hypothetical protein 1614759 84590945 An04g06520 Aspergillus niger hypothetical protein XP_059603610.1 1613435 D 5061 CDS An04g06530 4991060 join(1615578..1615976,1616031..1616477,1616564..1616610,1616660..1616705) VI 1 NT_166539.1 Function: zinc finger-containing proteins are usually transcription regulators, and the domain is directly involved in DNA binding.; Remark: the C2H2 zinc finger is composed of two short beta strands followed by an alpha helix; the amino terminal part of the helix binds the major groove in DNA binding zinc fingers.; Similarity: The C2H2 zinc finger is the classical zinc finger domain, where the two conserved cysteines and histidines co-ordinate a zinc ion.; Similarity: the main feature of the predicted ORF is to contain 6 C2H2 zinc finger domains, spanning all the protein lenght; this fact explains the huge number of BLASTP hits, mainly to hypothetical zinc finger proteins.; Title: similarity to hypothetical zinc-finger protein ZNF225 - Homo sapiens; uncharacterized protein 1616705 4991060 An04g06530 Aspergillus niger uncharacterized protein XP_001402017.3 1615578 D 5061 CDS An04g06540 84590946 complement(join(1618327..1618372,1618466..1618614)) VI 1 NT_166539.1 hypothetical protein 1618614 84590946 An04g06540 Aspergillus niger hypothetical protein XP_059603611.1 1618327 R 5061 CDS An04g06550 84590947 complement(join(1622149..1622381,1622506..1622736,1622910..1622934)) VI 1 NT_166539.1 Title: strong similarity to EST an_2064 -Aspergillus niger; uncharacterized protein 1622934 84590947 An04g06550 Aspergillus niger uncharacterized protein XP_059603612.1 1622149 R 5061 CDS An04g06560 84590948 complement(join(1623017..1623117,1623223..1623310,1623399..1623575,1623712..1623927)) VI 1 NT_166539.1 hypothetical protein 1623927 84590948 An04g06560 Aspergillus niger hypothetical protein XP_059603613.1 1623017 R 5061 CDS An04g06570 4991064 join(1624153..1624427,1624481..1624748) VI 1 NT_166539.1 Function: Ypd1p of S. cerevisiae is a phosphorelay intermediate between Sln1p and Ssk1p. Phenotype: disruption of YPD1 in S. cerevisisae is lethal because of the constitutive activation of the HOG1 MAPK cascade.; Remark: YDL235c ist the systematic name for YPD1 of s. cerevisisae.; Title: similarity to osmosensing phosphorelay signal transduction protein Ypd1 - Saccharomyces cerevisiae; See PMID 8808622; See PMID 10329790; uncharacterized protein 1624748 4991064 An04g06570 Aspergillus niger uncharacterized protein XP_059603614.1 1624153 D 5061 CDS An04g06580 4991065 join(1625102..1625305,1625495..1625660,1625749..1625856,1625898..1625965,1626037..1626150,1626236..1626305,1626406..1626471,1626580..1627470,1627568..1627698) VI 1 NT_166539.1 Title: weak similarity to aczonin - Mus musculus; uncharacterized protein 1627698 4991065 An04g06580 Aspergillus niger uncharacterized protein XP_059603615.1 1625102 D 5061 CDS An04g06590 4991066 complement(join(1627740..1628767,1628822..1628899,1628957..1629299)) VI 1 NT_166539.1 Title: weak similarity to protein from patent WO2003000906-A2 - Oryza sativa; uncharacterized protein 1629299 4991066 An04g06590 Aspergillus niger uncharacterized protein XP_059603616.1 1627740 R 5061 CDS An04g06600 4991067 complement(join(1629794..1629851,1630022..1630072,1630185..1630584,1630930..1630954)) VI 1 NT_166539.1 Title: similarity to EST SEQ ID NO:6881 from patent WO200056762-A2 - Aspergillus oryzae; uncharacterized protein 1630954 4991067 An04g06600 Aspergillus niger uncharacterized protein XP_059603617.1 1629794 R 5061 CDS An04g06610 84590949 join(1630977..1631070,1631197..1631384,1631689..1631790,1631892..1631931,1632169..1632303,1632671..1632771,1632823..1632911,1633102..1633168) VI 1 NT_166539.1 hypothetical protein 1633168 84590949 An04g06610 Aspergillus niger hypothetical protein XP_059603618.1 1630977 D 5061 CDS An04g06620 4991069 complement(join(1633511..1633796,1633861..1634136,1634188..1634305,1634357..1634484,1634545..1634619,1634674..1634829,1634951..1635483)) VI 1 NT_166539.1 Function: farnesyltransferase of H. sapiens is a heterodimeric enzyme that attaches a farnesyl group to a single cysteine in several cellular proteins (EC 2. 5. 1. -).; Pathway: substrates of FTPase beta subunit include the p21ras proteins, nuclear lamins, and several retinal proteins.; Remark: FTPase beta subunit and prenyl-protein transferase DPR1/RAM1 subunit homolog are alternativ names for human farnesyl-protein transferase beta chain.; Title: strong similarity to farnesyl-protein transferase beta chain - Homo sapiens; See PMID 8494894; uncharacterized protein 1635483 4991069 An04g06620 Aspergillus niger uncharacterized protein XP_001402026.1 1633511 R 5061 CDS An04g06630 84590950 join(1635998..1636071,1636396..1636545,1636628..1636774,1637043..1637273,1637359..1637434,1637516..1637578,1637710..1637932,1638036..1638066,1638174..1638288,1638410..1638466) VI 1 NT_166539.1 hypothetical protein 1638466 84590950 An04g06630 Aspergillus niger hypothetical protein XP_059603619.1 1635998 D 5061 CDS An04g06640 4991071 join(1639617..1640750,1640800..1641651,1641700..1641898,1641956..1642056) VI 1 NT_166539.1 Remark: blastp matches are unspecific.; Similarity: the ORF shows also similarity to EST n5c03a1. r1 of A. nidulans.; Similarity: the ORF shows weak similarity to the A. niger protein An08g02420. The similarity is only restricted to a stretch of about 50 amino acids.; Title: weak similarity to hypothetical protein encoded by An08g02420 - Aspergillus niger; uncharacterized protein 1642056 4991071 An04g06640 Aspergillus niger uncharacterized protein XP_001402028.1 1639617 D 5061 CDS An04g06650 4991072 join(1642928..1643355,1643428..1643570,1643644..1643705) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein SPBC19C2.15c - Schizosaccharomyces pombe; uncharacterized protein 1643705 4991072 An04g06650 Aspergillus niger uncharacterized protein XP_001402029.1 1642928 D 5061 CDS An04g06660 4991073 complement(join(1643866..1643945,1644002..1644307,1644370..1645225)) VI 1 NT_166539.1 Title: similarity to hypothetical protein G22F9.040 - Neurospora crassa; uncharacterized protein 1645225 4991073 An04g06660 Aspergillus niger uncharacterized protein XP_001402030.1 1643866 R 5061 CDS An04g06670 4991074 complement(join(1645830..1645932,1646007..1646136,1646226..1646286,1646362..1646418)) VI 1 NT_166539.1 Complex: the major small nuclear ribonucleoproteins (snRNPs) U1, U2, U4/U6, and U5 share a set of common proteins denoted B/B', D1, D2, D3, E, F, and G which play an important part in the biogenesis of the snRNPs.; Remark: SNRNP core protein D3 is an alternative name for small nuclear ribonucleoprotein SM D3 of H. sapiens.; Similarity: human SM D3 belongs to the SNRNP core protein family.; Title: strong similarity to small nuclear ribonucleoprotein SM D3 - Homo sapiens; nucleus; See PMID 7527560; uncharacterized protein 1646418 4991074 An04g06670 Aspergillus niger uncharacterized protein XP_001402031.1 1645830 R 5061 CDS An04g06680 4991075 1646858..1647547 VI 1 NT_166539.1 Similarity: the ORF encoded protein show similarity to several hypothetical proteins of different species.; Title: similarity to hypothetical protein 15E6.20 -Neurospora crassa; uncharacterized protein 1647547 4991075 An04g06680 Aspergillus niger uncharacterized protein XP_001402032.1 1646858 D 5061 CDS An04g06690 4991076 complement(join(1648374..1649650,1649702..1649901,1649952..1650289)) VI 1 NT_166539.1 Function: pah1 of P. anserina may be a repressor of genes involved in the microconidiation process. Moreover,pah1 is involved in hyphal branching and possibly in the development of female organs.; Phenotype: deletion of the pah1 gene in P. anserina enhances the number of male gametes (microconidia), whereas overexpression of pah1 results in a decrease in microconidia.; Title: strong similarity to homeoprotein h1 pah1 -Podospora anserina; nucleus; See PMID 11123688; uncharacterized protein 1650289 4991076 An04g06690 Aspergillus niger uncharacterized protein XP_001402033.1 1648374 R 5061 CDS An04g06700 84590951 join(1650420..1650584,1650638..1650684,1650751..1650775,1650910..1651059) VI 1 NT_166539.1 Title: weak similarity to hypothetical protein C01G5.3 - Caenorhabditis elegans; uncharacterized protein 1651059 84590951 An04g06700 Aspergillus niger uncharacterized protein XP_059603620.1 1650420 D 5061 CDS An04g06710 84590952 complement(join(1651911..1651981,1652039..1652146,1652413..1652516,1652601..1652758,1652793..1652837)) VI 1 NT_166539.1 hypothetical protein 1652837 84590952 An04g06710 Aspergillus niger hypothetical protein XP_059603621.1 1651911 R 5061 CDS An04g06720 84590953 complement(join(1653200..1653273,1653371..1653518,1653574..1653615,1653742..1653865,1653959..1654053,1654312..1654344)) VI 1 NT_166539.1 hypothetical protein 1654344 84590953 An04g06720 Aspergillus niger hypothetical protein XP_059603622.1 1653200 R 5061 CDS An04g06730 4991080 complement(join(1655346..1655388,1655465..1655494,1655525..1655560,1655601..1655631,1655718..1655792,1656127..1657486)) VI 1 NT_166539.1 Function: Ttp1 participates in the cellular event of glycoprotein glycosylation essential for growth and morphogenesis, in parallel with the pathways involving Mpk1 MAP kinase and calcineurin.; Golgi; Phenotype: mnn2 mutants are defective in the addition of the first -1,2-linked mannose as it has no branches on the backbone.; Remark: MNN2 and YBR015C are alternative names for TTP1 (type II membrane protein).; Title: similarity to mannosyltransferases Ttp1 -Saccharomyces cerevisiae; See PMID 9413431; See PMID 9756928; uncharacterized protein 1657486 4991080 An04g06730 Aspergillus niger uncharacterized protein XP_059603623.1 1655346 R 5061 CDS An04g06740 84590954 join(1657774..1657865,1657944..1658003,1658902..1658969,1659096..1659239,1659340..1659386) VI 1 NT_166539.1 Title: questionable ORF; uncharacterized protein 1659386 84590954 An04g06740 Aspergillus niger uncharacterized protein XP_059603624.1 1657774 D 5061 CDS An04g06750 4991082 join(1659941..1660008,1660097..1660586) VI 1 NT_166539.1 Title: similarity to hypothetical transmembrane protein - Candida albicans; uncharacterized protein 1660586 4991082 An04g06750 Aspergillus niger uncharacterized protein XP_001402039.1 1659941 D 5061 CDS An04g06760 84590955 complement(join(1660947..1661000,1661083..1661624,1661676..1661761,1661888..1661945,1662045..1662066)) VI 1 NT_166539.1 hypothetical protein 1662066 84590955 An04g06760 Aspergillus niger hypothetical protein XP_059603625.1 1660947 R 5061 CDS An04g06790 10098339 1662180..1666592 VI 1 NT_166539.1 Catalytic activity: Deoxynucleoside triphosphate + DNA(n) = Pyrophosphate + DNA(n+1).; Remark: catalyses RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo. Requires an RNA or DNA primer. DNA can also serve as template.; Remark: in plants, retrotransposons have been described in maize, Arabidopsis and wheat, and non-viral retroposons in maize.; Remark: transcription and transposition of Tto1 were observed in rice cells.; Title: similarity to retrotransposon Tto1 -Nicotiana tabacum; See PMID 8624443; uncharacterized protein 1666592 10098339 An04g06790 Aspergillus niger uncharacterized protein XP_003188677.2 1662180 D 5061 CDS An04g06800 84590956 complement(join(1666806..1667480,1667576..1667824,1667876..1667953)) VI 1 NT_166539.1 Title: weak similarity to hypothetical protein C34C6.1 - Caenorhabditis elegans; uncharacterized protein 1667953 84590956 An04g06800 Aspergillus niger uncharacterized protein XP_059603626.1 1666806 R 5061 CDS An04g06820 84590957 complement(join(1668049..1668117,1668200..1668373,1668480..1668554)) VI 1 NT_166539.1 hypothetical protein 1668554 84590957 An04g06820 Aspergillus niger hypothetical protein XP_059603627.1 1668049 R 5061 CDS An04g06830 84590958 complement(join(1669203..1669482,1669556..1669869)) VI 1 NT_166539.1 hypothetical protein 1669869 84590958 An04g06830 Aspergillus niger hypothetical protein XP_059603628.1 1669203 R 5061 CDS An04g06840 4991088 complement(1670888..1675903) VI 1 NT_166539.1 Remark: alternate names for S. cerevisiae Drs2: Fun38, Swa8 or YAL026C.; Similarity: DRS2 is a member of the cation transporting (E1-E2) P-type ATPase superfamily.; Title: similarity to ATPase Drs2 - Saccharomyces cerevisiae; See PMID 10601336; See PMID 8247005; uncharacterized protein 1675903 4991088 An04g06840 Aspergillus niger uncharacterized protein XP_001402045.1 1670888 R 5061 CDS An04g06850 84590959 join(1675917..1675995,1676208..1676303,1676355..1676478,1676519..1676546,1676664..1676731,1676776..1676902) VI 1 NT_166539.1 Remark: similarity is due to glutamate-rich region of the protein.; Title: weak similarity to retinitis pigmentosa GTPase regulator RPGR - Homo sapiens; uncharacterized protein 1676902 84590959 An04g06850 Aspergillus niger uncharacterized protein XP_059603629.1 1675917 D 5061 CDS An04g06860 84590960 join(1678822..1678854,1679081..1679404,1679462..>1679556) VI 1 NT_166539.1 Remark: cypX from A. parasiticus is expressed concurrently with genes involved in aflatoxin biosynthesis.; Remark: putative sequencing error in second exon.; Title: similarity to cytochrome P450 monooxigenase cypX - Aspergillus parasiticus [putative frameshift]; putative frameshift; See PMID 10855719; uncharacterized protein 1679556 84590960 An04g06860 Aspergillus niger uncharacterized protein XP_059603630.1 1678822 D 5061 CDS An04g06870 4991091 complement(join(1680899..1681333,1681381..1681448,1681508..1682345,1682461..1682892,1683224..1683289,1683454..1683594,1683800..1683805)) VI 1 NT_166539.1 Similarity: the ORF shows similarity to the A. niger protein An01g00660. The ORF is longer than An01g00660.; Title: similarity to hypothetical protein CAD21072.1 - Neurospora crassa; uncharacterized protein 1683805 4991091 An04g06870 Aspergillus niger uncharacterized protein XP_059603631.1 1680899 R 5061 CDS An04g06880 4991092 1685500..1686762 VI 1 NT_166539.1 Remark: S. spectabilis spcB was cloned as part of the spectinomycin biosynthesis cluster and encodes a putative myoinositol-dehydrogenase.; Title: similarity to hypothetical myoinositol-dehydrogenase spcB - Streptomyces spectabilis; See PMID 10650224; uncharacterized protein 1686762 4991092 An04g06880 Aspergillus niger uncharacterized protein XP_001402049.1 1685500 D 5061 CDS An04g06890 4991093 complement(join(1687208..1688423,1688552..1688627,1688686..1688959,1689049..1689369)) VI 1 NT_166539.1 Complex: in C. familiaris the 68- (SRP68) and 72-(SRP72) kD proteins of SRP are bound to the 7S RNA of SRP as a heterodimeric complex (SRP68/72), whereby SRP68 mediates the interaction with the 7S RNA.; Function: C. familiaris SRP72 is a component of the cytoplasmic ribonucleoprotein particle that mediates the targeting of proteins to the ER.; Title: similarity to 72-kD protein of the signal recognition particle SRP72 - Canis lupus; cytoplasm; See PMID 8388879; uncharacterized protein 1689369 4991093 An04g06890 Aspergillus niger uncharacterized protein XP_059603632.1 1687208 R 5061 CDS An04g06900 4991094 join(1691661..1693000,1693187..1693232) VI 1 NT_166539.1 Title: similarity to hypothetical protein F24K9.9 -Arabidopsis thaliana; uncharacterized protein 1693232 4991094 An04g06900 Aspergillus niger uncharacterized protein XP_001402051.3 1691661 D 5061 CDS An04g06910 4991095 complement(join(<1693848..1694155,1694214..1694664,1694716..1695695)) VI 1 NT_166539.1 Protein sequence is in conflict with the conceptual translation; Function: A. oryzae amyR gene disruptants showed a significant restricted growth on starch medium and produced little of the amylolytic enzymes including alpha-amylase and glucoamylase.; Function: A. oryzae amyR is a transcriptional activator gene involved in starch/maltose-induced efficient expression of the amylolytic genes.; Gene-ID: amyR; Induction: in A. oryzae amyR was expressed in the presence of glucose comparable to the level in the presence of maltose, while the amylolytic genes amyA and agdA were transcribed at high levels only in the presence of maltose.; Remark: information concerning A. niger amyR has not yet been published.; Remark: the genomic organisation of alpha-amylase,aglA and amyR in A. niger is identical to the organisation in A. oryzae.; nucleus; putative frameshift; See PMID 10830498; transcription regulator of maltose utilization amyR-Aspergillus niger 1695695 amyR 4991095 amyR Aspergillus niger transcription regulator of maltose utilization amyR-Aspergillus niger XP_059603633.1 1693848 R 5061 CDS An04g06920 4991096 join(1697425..1698119,1698180..1698590,1698643..1698813,1698868..1700548) VI 1 NT_166539.1 Catalytic activity: alpha-glucosidases hydrolyse the terminal, non-reducing 1,4-linked D-glucose residues with release of D-glucose.; Gene-ID: aglU; Remark: the assigned gene name aglA in the SWISSPROT entry P56526 is probably wrong, because no other source could be found and the alpha-galactosidase of A. niger is also named as aglA.; extracellular/secretion proteins; See PMID 9165762; extracellular alpha-glucosidase aglU-Aspergillus niger 1700548 aglU 4991096 aglU Aspergillus niger extracellular alpha-glucosidase aglU-Aspergillus niger XP_001402053.1 1697425 D 5061 CDS An04g06930 4991097 join(1701189..1701341,1701393..1701431,1701498..1701613,1701671..1701779,1701831..1702059,1702123..1702285,1702336..1702482,1702538..1702778,1702836..1703115,1703212..1703272,1703351..>1703388) VI 1 NT_166539.1 Protein sequence is in conflict with the conceptual translation; Catalytic activity: alpha-amylases catalyse the endohydrolysis of 1,4-alpha-glucosidic linkages in oligosaccharides and polysaccharides.; Similarity: the predicted A. niger protein differs in few, especially terminal, aa from both known A. awamori alpha-amylase proteins, amy A and B.; Title: strong similarity to extracellular alpha-amylase amyA/amyB - Aspergillus niger; putative frameshift; See PMID 2340591; uncharacterized protein 1703388 4991097 An04g06930 Aspergillus niger uncharacterized protein XP_001402054.3 1701189 D 5061 CDS An04g06940 4991098 complement(join(1704858..1705444,1705496..1705725,1705776..1706201,1706260..1706661,1706774..1707000)) VI 1 NT_166539.1 Function: S. pombe SPAC1399_1 is a possible regulator of maltose fermentation and contains a fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain.; Gene-ID: PrtT; Remark: the A. niger transcription factor might be a regulator of the genomically adjacent gene-cluster of amylolytic enzymes.; Similarity: the predicted A. niger protein shows similarity to the fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain of several transcripton factors.; transcriptional activator of proteases PrtT from patent WO200020596-A1-Aspergillus niger 1707000 PrtT 4991098 PrtT Aspergillus niger transcriptional activator of proteases PrtT from patent WO200020596-A1-Aspergillus niger XP_001402055.1 1704858 R 5061 CDS An04g06950 4991099 complement(join(1716710..1716877,1716943..1717692,1717777..1717842)) VI 1 NT_166539.1 Function: D. melanogaster hth regulates the subcellular localization of the homeotic protein cofactor Extradenticle (EXD) via its N-terminal MH-domain; Similarity: D. melanogaster hth encodes a TALE class homeodomain-containing protein of the MEIS family.; Similarity: the predicted A. niger protein shows similarity to the homeodomain of several MEIS familiy proteins, but not to the MH-domain of hth.; Title: similarity to homeobox transcription factor hth - Drosophila melanogaster; nucleus; See PMID 11156989; uncharacterized protein 1717842 4991099 An04g06950 Aspergillus niger uncharacterized protein XP_059603634.1 1716710 R 5061 CDS An04g06960 4991100 complement(join(1730449..1732466,1732546..1732549)) VI 1 NT_166539.1 Catalytic activity: NADPH + 2 Ferricytochrome = NADP+ + 2 Ferrocytochrome.; Remark: all known plant cytochrome P450 monooxygenase reactions depend on the associated activity of an NADPH:cytochrome P450 oxidoreductase (CPR; EC 1. 6. 2. 4) that catalyzes the transfer of electrons from NADPH via FAD and FMN to the prosthetic heme group of the P450 protein. Although for animal systems detailed characteristics including structural properties of CPRs have been reported, only few of these enzymes have been purified and cloned from plant sources.; Title: strong similarity to NADPH-ferrihemoprotein reductase 1 CPR1 - Petroselinum crispum; See PMID 9405720; uncharacterized protein 1732549 4991100 An04g06960 Aspergillus niger uncharacterized protein XP_059603635.1 1730449 R 5061 CDS An04g06970 4991101 complement(join(1735948..1736397,1736455..1736780,1736829..1737230,1737281..1737363,1737435..1737548,1737631..1737671,1737718..1737873)) VI 1 NT_166539.1 Remark: transcript level analyses demonstrate that gabA is subject to carbon catabolite and nitrogen metabolite repression.; Similarity: to other choline transport proteins.; Title: strong similarity to GABA permease gabA -Aspergillus nidulans; See PMID 10320578; uncharacterized protein 1737873 4991101 An04g06970 Aspergillus niger uncharacterized protein XP_059603636.1 1735948 R 5061 CDS An04g06980 4991102 join(1739318..1739515,1739592..1739688,1739755..1739969,1740055..1740191,1740285..1740798) VI 1 NT_166539.1 Function: The M. grisea PTH11 gene product is presumably involved in host surface recognition and can activate appressorium differentiation in response to inductive surface cues.; Function: The PTH11 gene of the rice blast fungus Magnaporthe grisea encodes a novel upstream component of pathogenicity signaling.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529; uncharacterized protein 1740798 4991102 An04g06980 Aspergillus niger uncharacterized protein XP_059603637.1 1739318 D 5061 CDS An04g06990 4991103 complement(join(1741053..1741101,1741175..1741432,1741488..1742225,1742328..1743022)) VI 1 NT_166539.1 Catalytic activity: the human protein removes a single mannose residue from Man9GlcNAc; the product is Man8GlcNAc isomer B.; Function: might be involved in glycoprotein quality control since there is evidence that trimming of Man9GlcNAc2 to Man8GlcNAc2 isomer B in yeast cells is important to target misfolded glycoproteins for degradation.; Remark: calcium is required for enzyme activity.; Remark: the properties and specificity of this human alpha 1,2-mannosidase are identical to the endoplasmic reticulum alpha 1,2-mannosidase from S. cerevisiae.; Similarity: sequence similarity to Class I alpha 1,2-mannosidases.; Title: strong similarity to alpha 1,2-mannosidase IC - Homo sapiens; uncharacterized protein 1743022 4991103 An04g06990 Aspergillus niger uncharacterized protein XP_001402060.1 1741053 R 5061 CDS An04g07000 4991104 join(1744573..1744586,1744643..1745627) VI 1 NT_166539.1 hypothetical protein 1745627 4991104 An04g07000 Aspergillus niger hypothetical protein XP_059603638.1 1744573 D 5061 CDS An04g07010 4991105 complement(join(1746381..1746415,1746472..1746684,1746752..1746877,1746996..1747011,1747102..1747158,1747269..1747271)) VI 1 NT_166539.1 Function: CaM of E. nidulans activates vertebrate CaM-dependent phosphodiesterases, CaM-dependent protein kinases II, and myosin light chain kinases.; Function: CaM of E. nidulans is essential for cell cycle progression.; Title: strong similarity to calmodulin caM -Aspergillus nidulans; See PMID 2199442; uncharacterized protein 1747271 4991105 An04g07010 Aspergillus niger uncharacterized protein XP_001402062.1 1746381 R 5061 CDS An04g07020 4991106 join(1749041..1749063,1749131..1749663,1749723..1750288) VI 1 NT_166539.1 Complex: TLG2 of S. cerevisiae interacts with vps45.; Function: TLG2 od S. cerevisiae is a t-SNARE which is involved in early endosome biogenesis.; Function: TLG2 of S. cerevisiae is a t-SNARE that functions in transport from the endosome to the late golgi and on the endocytic pathway.; Remark: SNAREs (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptors) are cytoplasmically oriented membrane proteins that reside on vesicular carriers (v-SNARE) and target organelles (t-SNARE). The pairing of a stage-specific v-SNARE with its cognate t-SNARE may mediate the specificity of membrane traffic.; Remark: YOL018c and TLG2 of S. cerevisiae are synonymous names.; Similarity: TLG2 of S. cerevisiae belongs to the syntaxin/epimorphin family.; Title: strong similarity to syntaxin Tlg2 -Saccharomyces cerevisiae; See PMID 9763449; See PMID 10028187; uncharacterized protein 1750288 4991106 An04g07020 Aspergillus niger uncharacterized protein XP_059603639.1 1749041 D 5061 CDS An04g07030 4991107 complement(join(1750735..1751591,1751643..1751784,1751837..1751895,1751948..1752039,1752099..1752109)) VI 1 NT_166539.1 Title: similarity to hypothetical protein SPBC337.03 - Schizosaccharomyces pombe; uncharacterized protein 1752109 4991107 An04g07030 Aspergillus niger uncharacterized protein XP_001402064.3 1750735 R 5061 CDS An04g07040 4991108 join(1752687..1752726,1752783..1753026,1753086..1753192,1753291..>1753642) VI 1 NT_166539.1 Complex: Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat. In the presence of light chains, hub assembly is influenced by both the pH and the concentration of calcium.; Function: Clathrin is the major protein of the polyhedral coat of coated pits & vesicles. Two different adaptor protein complexes link the clathrin lattice either to the plasma membrane or trans golgi network.; Remark: a putative sequencing error results in an frameshift.; Title: strong similarity to clathrin light chain Clc1 - Saccharomyces cerevisiae [putative frameshift]; putative frameshift; See PMID 8955161; See PMID 9133677; See PMID 2211819; See PMID 7585943; uncharacterized protein 1753642 4991108 An04g07040 Aspergillus niger uncharacterized protein XP_059603640.1 1752687 D 5061 CDS An04g07050 4991109 complement(join(1754258..1754762,1754821..1755785)) VI 1 NT_166539.1 Function: CDC37 of S. cerevisiae functions as a protein chaperone with similar properties as Hsp82p.; Remark: CDC37 of S. cerevisiae interacts with MAP kinases.; Remark: CDC37 of S. cerevisiae may interact with several kinase systems either as a general kinase activator or as a phosphatase inhibitor.; Title: strong similarity to cell division control protein Cdc37 - Saccharomyces cerevisiae; See PMID 9060463; See PMID 10629030; uncharacterized protein 1755785 4991109 An04g07050 Aspergillus niger uncharacterized protein XP_001402066.1 1754258 R 5061 CDS An04g07060 4991110 join(1756280..1757521,1757582..1758217,1758269..1758754) VI 1 NT_166539.1 Remark: Mdl1 of S. cerevisiae is an intracellular peptide transporter localized in the inner membrane of yeast mitochondria.; Title: strong similarity to peptide ABC transporter protein Mdl1 - Saccharomyces cerevisiae; See PMID 11251115; uncharacterized protein 1758754 4991110 An04g07060 Aspergillus niger uncharacterized protein XP_001402067.1 1756280 D 5061 CDS An04g07070 4991111 join(1759311..1759486,1759550..1760711) VI 1 NT_166539.1 Function: FUN26 of S. cerevisiae has broad nucleoside selectivity and most likely functions to transport nucleosides across intracellular membranes.; Title: strong similarity to intracellular membrane protein involved in nucleoside transport Fun26 -Saccharomyces cerevisiae; See PMID 10827169; uncharacterized protein 1760711 4991111 An04g07070 Aspergillus niger uncharacterized protein XP_001402068.1 1759311 D 5061 CDS An04g07080 4991112 complement(join(1761224..1761599,1761677..1762535,1762688..1762754)) VI 1 NT_166539.1 Title: similarity to hypothetical protein SPBC2G5.01 - Schizosaccharomyces pombe; uncharacterized protein 1762754 4991112 An04g07080 Aspergillus niger uncharacterized protein XP_001402069.1 1761224 R 5061 CDS An04g07090 4991113 complement(join(1763524..1764880,1764952..1765256)) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein SPBC19C2.11c - Schizosaccharomyces pombe; uncharacterized protein 1765256 4991113 An04g07090 Aspergillus niger uncharacterized protein XP_001402070.3 1763524 R 5061 CDS An04g07100 4991114 join(1767175..1768416,1768476..1768762,1768848..1769310) VI 1 NT_166539.1 Function: Haspin is likely to be important in regulation of haploid as well as diploid cell differentiation in a variety of tissues.; Function: Haspin of M. musculus is a serine/threonine kinase that is thought to regulate cell cycle and differentiation of haploid germ cells.; Remark: Haspin was so far found only in humans and mice.; Similarity: Haspin is a member of a new family of protein kinases.; Title: similarity to haploid germ cell-specific nuclear protein kinase (haspin) GSG2 - Mus musculus; deleted EC_number 2.7.1.37; See PMID 10358056; See PMID 11311556; uncharacterized protein 1769310 4991114 An04g07100 Aspergillus niger uncharacterized protein XP_059603641.1 1767175 D 5061 CDS An04g07110 4991115 complement(join(<1769701..1770085,1770166..1770479)) VI 1 NT_166539.1 Catalytic activity: Chitin + H(2)O = chitosan + acetate.; Function: CDA1 hydrolyses the N-acetamido groups of N-acetyl-D-glucosamine residues in chitin.; Function: CDA1 of S. cerevisiae is involved ascospore wall formation.; Remark: YLR307w is a synonymous name to CDA1.; Remark: the sequencing error is confirmed (ORF-sequence is correct) and results in a frameshift.; Title: similarity to sporulation-specific chitin deacetylase Cda1 - Saccharomyces cerevisiae [putative sequencing error]; putative sequencing error; See PMID 8940152; uncharacterized protein 1770479 4991115 An04g07110 Aspergillus niger uncharacterized protein XP_001402072.3 1769701 R 5061 CDS An04g07120 4991116 complement(join(1771166..1771371,1771428..1771542,1771604..1772182)) VI 1 NT_166539.1 Function: FRM2 of yeast functions in the fatty acid signalling pathway and is itself regulated by fatty acids.; Remark: A better BlastpPATENT hit was not annotated as a clear function could not be identified for it.; Remark: FRM2 of yeast is N-terminally 90 aa shorter than the gene product of this ORF.; Title: similarity to protein FRM2 involved in fatty acid regulation - Saccharomyces cerevisiae; See PMID 8701605; uncharacterized protein 1772182 4991116 An04g07120 Aspergillus niger uncharacterized protein XP_001402073.3 1771166 R 5061 CDS An04g07130 4991117 complement(join(1773047..1773250,1773307..1774059)) VI 1 NT_166539.1 Remark: SPCC4B3. 10c of S. pombe is N-terminally approx. 380 aa longer.; Title: similarity to hypothetical protein SPCC4B3.10c - Schizosaccharomyces pombe; uncharacterized protein 1774059 4991117 An04g07130 Aspergillus niger uncharacterized protein XP_059603642.1 1773047 R 5061 CDS An04g07140 84590961 join(1774225..1774264,1774349..1774514,1774613..1774699,1774755..1775021,1775105..1775229,1775336..1775435,1775594..1775679,1776048..1776457) VI 1 NT_166539.1 hypothetical protein 1776457 84590961 An04g07140 Aspergillus niger hypothetical protein XP_059603643.1 1774225 D 5061 CDS An04g07150 4991119 join(1776553..1776618,1776971..1777076,1777171..1777273,1777418..1777457,1777489..1777599) VI 1 NT_166539.1 Remark: YBL001c and ECM15 are synonymous names.; Title: strong similarity to protein involved in cell wall biogenesis and architecture Ecm15 - Saccharomyces cerevisiae; See PMID 9335584; uncharacterized protein 1777599 4991119 An04g07150 Aspergillus niger uncharacterized protein XP_001402076.3 1776553 D 5061 CDS An04g07160 4991120 complement(join(1777829..1778592,1778661..1778836,1778891..1779078)) VI 1 NT_166539.1 Title: similarity to hypothetical protein MLD14.3 -Arabidopsis thaliana; uncharacterized protein 1779078 4991120 An04g07160 Aspergillus niger uncharacterized protein XP_001402077.1 1777829 R 5061 CDS An04g07170 4991121 complement(join(1779650..1779802,1779886..1782396)) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein EAA65067.1 - Aspergillus nidulans; uncharacterized protein 1782396 4991121 An04g07170 Aspergillus niger uncharacterized protein XP_001402078.3 1779650 R 5061 CDS An04g07180 4991122 join(1782803..1782831,1783013..1783091,1783163..1783223,1783282..1783313,1783387..1783416) VI 1 NT_166539.1 Remark: Gene structure was modelled according to A. niger EST.; Remark: ORF is also identical to DNA sequence patent AAF11781.; Title: strong similarity to EST an_2144 -Aspergillus niger; uncharacterized protein 1783416 4991122 An04g07180 Aspergillus niger uncharacterized protein XP_001402079.1 1782803 D 5061 CDS An04g07190 4991123 join(1784311..1784372,1784435..1784609,1784663..1784718,1784776..1785188,1785221..1786137,1786188..1786625) VI 1 NT_166539.1 Title: similarity to hypothetical transcription regulator protein - Schizosaccharomyces pombe; uncharacterized protein 1786625 4991123 An04g07190 Aspergillus niger uncharacterized protein XP_059603644.1 1784311 D 5061 CDS An04g07200 4991124 complement(join(1786821..1787236,1787301..1787778,1787831..1788168,1788215..1788374)) VI 1 NT_166539.1 Catalytic activity: L-kynurenine + H(2)O <=> anthranilate + L-alanine.; Function: The kynureninase from rat is one of the enzymes involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway.; Remark: A pyridoxal-phosphate protein, also acts on 3'-hydroxykynurenine and some other (3-arylcarbonyl)-alanines.; Title: strong similarity to kynureninase - Rattus norvegicus; See PMID 9180257; uncharacterized protein 1788374 4991124 An04g07200 Aspergillus niger uncharacterized protein XP_001402081.1 1786821 R 5061 CDS An04g07210 4991125 join(1788849..1789142,1789238..1789858,1789923..1790303) VI 1 NT_166539.1 Catalytic activity: Tryptophan + O2 = N-formylkynurenine.; Function: IDO of mouse is a hemoprotein that catalyzes the degradation of tryptophan to N-formyl-kynurenine.; Title: strong similarity to indoleamine 2,3-dioxygenase IDO - Mus musculus; See PMID 1937018; uncharacterized protein 1790303 4991125 An04g07210 Aspergillus niger uncharacterized protein XP_001402082.1 1788849 D 5061 CDS An04g07220 4991126 join(1792117..1793177,1793221..1793242) VI 1 NT_166539.1 Catalytic activity: (S)-(2-hydroxyacyl)glutathione + H(2)O = glutathione + A 2-hydroxy acid anion.; Pathway: glyoxal pathway.; Similarity: ORF has strong similarity to many hypothetical proteins (e. g. metallo-beta-lactamase family proteins).; Similarity: belongs to the glyoxalase II family.; Title: similarity to hydroxyacylglutathione hydrolase (glyoxylase II) HAGH - Homo sapiens; See PMID 8550579; uncharacterized protein 1793242 4991126 An04g07220 Aspergillus niger uncharacterized protein XP_059603645.1 1792117 D 5061 CDS An04g07230 4991127 join(1793665..1793976,1794031..1794289,1794341..1794429) VI 1 NT_166539.1 Catalytic activity: L-Cysteine + O2 = 3-Sulfino-L-alanine.; Function: Cysteine dioxygenase is a key enzyme of cysteine metabolism in mammals.; Title: strong similarity to cysteine dioxygenase CDO1 - Rattus norvegicus; uncharacterized protein 1794429 4991127 An04g07230 Aspergillus niger uncharacterized protein XP_001402084.1 1793665 D 5061 CDS An04g07240 4991128 1795070..1796803 VI 1 NT_166539.1 Function: MAL13 regulates the coordinate transcription of structural mal1s (maltase) and agt1 (maltose permease) genes.; Localization: nuclear.; Remark: MAL13 contains a Zn[2]-Cys[6] fungal-type binuclear cluster domain.; Remark: YGR288w, MAL1R, and MAL13 are synonymous names.; Title: similarity to maltose pathway regulatory protein Mal13 - Saccharomyces cerevisiae; See PMID 2037232; See PMID 2278509; uncharacterized protein 1796803 4991128 An04g07240 Aspergillus niger uncharacterized protein XP_001402085.1 1795070 D 5061 CDS An04g07250 4991129 complement(join(1797915..1798621,1798686..1798710,1798772..1798804)) VI 1 NT_166539.1 Similarity: ORF is also similar to human AF-9 protein which is involved in a T(9:11)(P22:Q23) chromosomal translocation in acute leukemias causing fusion to the trithorax (mll or hrx) gene product which contains DNA-binding motifs resulting in a rogue activator protein.; Title: strong similarity to hypothetical transcription factor - Schizosaccharomyces pombe; uncharacterized protein 1798804 4991129 An04g07250 Aspergillus niger uncharacterized protein XP_001402086.1 1797915 R 5061 CDS An04g07260 4991130 join(1799137..1799182,1799261..1799315,1799378..1799718,1799786..1800207) VI 1 NT_166539.1 Function: eryBIV of S. erythrae is involved in erythromycin biosynthesis.; Remark: eryBIV of S. erythrae is also described in patent AAX25774.; Similarity: the ORF encoded protein shows strong similarity to the hypothetical proteins YLL056c from S. cerevisiae and SPBC2A9. 02 from S. pombe.; Title: similarity to dTDP-4-keto-L-6-deoxyhexose-4-reductase eryBIV -Saccharopolyspora erythraea; See PMID 9353926; uncharacterized protein 1800207 4991130 An04g07260 Aspergillus niger uncharacterized protein XP_001402087.1 1799137 D 5061 CDS An04g07270 4991131 complement(join(1800829..1800876,1800928..1801563,1801622..1801864)) VI 1 NT_166539.1 Function: human GCIP is a cyclin D-interacting protein, which reduces the phosphorylation of retinoblastoma protein by cyclin D-dependent protein kinase and inhibits E2F1-mediated transcriptional activity.; Localization: human HA-tagged p29 in HeLa cells localized in the nucleus.; Remark: human GCIP interacting protein p29 is identical to the cDNA DKFZp564O2082. 1.; Remark: human GCIP interacting protein p29 was identified using a yeast two-hybrid screen with GCIP as bait.; Title: strong similarity to GCIP-interacting protein p29 - Homo sapiens; nucleus; See PMID 10801854; See PMID 11118353; uncharacterized protein 1801864 4991131 An04g07270 Aspergillus niger uncharacterized protein XP_001402088.1 1800829 R 5061 CDS An04g07280 4991132 join(1802222..1802975,1803180..1804144) VI 1 NT_166539.1 Remark: the 3'UTR of the predicted A. niger protein is covered by the A. niger EST an_1913.; hypothetical protein 1804144 4991132 An04g07280 Aspergillus niger hypothetical protein XP_059603646.1 1802222 D 5061 CDS An04g07290 84590962 join(1804879..1804913,1805157..1805214,1805303..1805431,1805515..1805635,1805729..1805867,1806087..1806173,1806218..1806320,1806371..1806555,1806713..1806875) VI 1 NT_166539.1 hypothetical protein 1806875 84590962 An04g07290 Aspergillus niger hypothetical protein XP_059603647.1 1804879 D 5061 CDS An04g07300 84590963 complement(join(1808207..1808428,1808654..1808704)) VI 1 NT_166539.1 Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1808704 84590963 An04g07300 Aspergillus niger uncharacterized protein XP_059603648.1 1808207 R 5061 CDS An04g07310 84590964 complement(join(1808837..1809075,1809182..1809256,1809678..1809990)) VI 1 NT_166539.1 Similarity: similarity is from the predicted A. niger protein to the EGF-domain of D. rotundus DSPA alpha 1, which contains a signal peptide, a finger (F), an epidermal growth factor (EGF), a kringle, and a serine protease domain.; Title: weak similarity to t-plasminogen activator alpha-1 DSPA-alpha1 - Desmodus rotundus; uncharacterized protein 1809990 84590964 An04g07310 Aspergillus niger uncharacterized protein XP_059603649.1 1808837 R 5061 CDS An04g07320 84590965 join(1810534..1811309,1811677..1811757,1811795..1811840,1812005..1812010,1812061..1812102) VI 1 NT_166539.1 Function: mutations in veA allows conidiation to occur in the absence of light.; Title: similarity to dark repressor of conidiation velvet veA - Aspergillus nidulans; See PMID 2076818; uncharacterized protein 1812102 84590965 An04g07320 Aspergillus niger uncharacterized protein XP_059603650.1 1810534 D 5061 CDS An04g07330 4991137 complement(join(1812908..1813231,1813371..1813604)) VI 1 NT_166539.1 Function: human MRPL12 is thought to act as a translational regulator of mitochondrial mRNAs.; Remark: the 3'UTR of the predicted A. niger protein is covered by the A. niger EST an_1220.; Title: strong similarity to mitochondrial ribosomal protein of the large subunit L12 - Homo sapiens; localisation:mitochondrion; See PMID 8626705; See PMID 9169145; mitochondrial 54S ribosomal protein bL12m 1813604 4991137 An04g07330 Aspergillus niger mitochondrial 54S ribosomal protein bL12m XP_001402094.1 1812908 R 5061 CDS An04g07340 4991138 complement(join(1814073..1815352,1815461..1815831,1815968..1816026)) VI 1 NT_166539.1 Complex: in S. cerevisiae CCT1-8 form the Cct chaperonin complex.; Function: S. cerevisiae CCT8 is a subunit of the Cct chaperonin complex which binds to newly synthesized actin and tubulin and can convert these proteins into an assembly-competent state.; Localization: S. cerevisiae CCT localized to the cytoplasm and the cell cortex.; Remark: an alternativ name for the S. cerevisiae Cct chaperonin complex is TCP-1.; Similarity: S. cerevisiae CCT shows similarity to GroEl.; Title: strong similarity to hypothetical cytoskeleton specific chaperonin subunit Cct8 -Saccharomyces cerevisiae; See PMID 7865875; See PMID 7916461; See PMID 8771707; uncharacterized protein 1816026 4991138 An04g07340 Aspergillus niger uncharacterized protein XP_001402095.1 1814073 R 5061 CDS An04g07350 84590966 join(1817181..1817343,1817437..1817528,1817614..1817848,1817882..1817892) VI 1 NT_166539.1 Remark: the 5'UTR of the predicted A. niger protein is covered by the A. niger EST an_2917.; Title: weak similarity to hypothetical helicase I helA - Pseudomonas aeruginosa; See PMID 8820243; uncharacterized protein 1817892 84590966 An04g07350 Aspergillus niger uncharacterized protein XP_059603651.1 1817181 D 5061 CDS An04g07360 4991140 complement(join(1818291..1819029,1819085..1819485)) VI 1 NT_166539.1 Title: similarity to hypothetical protein CAD70815.1 - Neurospora crassa; uncharacterized protein 1819485 4991140 An04g07360 Aspergillus niger uncharacterized protein XP_001402097.3 1818291 R 5061 CDS An04g07370 4991141 complement(1820588..1821826) VI 1 NT_166539.1 Catalytic activity: salicylate 1-monooxygenases convert salicylate + NADH + O(2) to catechol + NAD(+) + H(2)O + CO(2).; Function: P. stutzeri nahW is involved in naphthalene and salicylate metabolism, metabolising salicylate, methylsalicylates, and chlorosalicylates.; Induction: P. stutzeri nahW is induced and expressed upon incubation with salicylate.; Title: similarity to salicylate hydroxylase nahW -Pseudomonas stutzeri; See PMID 10197990; uncharacterized protein 1821826 4991141 An04g07370 Aspergillus niger uncharacterized protein XP_001402098.1 1820588 R 5061 CDS An04g07380 4991142 complement(join(<1822248..1822426,1822479..1822510,1822565..1822628,1822688..1822733,1822784..1822808,1822863..1823103,1823180..1823421,1823487..1823869,1823970..1824048,1824230..1824323,1824462..1824492,1824547..1824670)) VI 1 NT_166539.1 Remark: see reference PubMed 10375630 for details on phenotype of S. cerevisiae YKR087c deletion mutant.; Remark: the ORF is C-terminally truncated due to contig border.; Similarity: the ORF might encode a Zn-dependent protease, as predicted for the homologues S. pombe protein,but the predicted ORF is N-terminally extended.; Title: strong similarity to hypothetical peptidase 48 family protein SPAP14E8.04 - Schizosaccharomyces pombe [truncated ORF]; See PMID 10375630; uncharacterized protein 1824670 4991142 An04g07380 Aspergillus niger uncharacterized protein XP_059603652.1 1822248 R 5061 CDS An04g07390 84590967 complement(join(1826223..1826543,1826637..1826711,1827111..1827274,1827463..1827600,1827680..1827977,1828148..1828232,1828314..1828494,1828613..1828740,1828787..1828848)) VI 1 NT_166539.1 Title: weak similarity to hypothetical protein KIAA1359 - Homo sapiens; uncharacterized protein 1828848 84590967 An04g07390 Aspergillus niger uncharacterized protein XP_059603653.1 1826223 R 5061 CDS An04g07400 4991144 join(1829113..1829263,1829332..1831101,1831180..1831349) VI 1 NT_166539.1 Remark: a putative sequencing error generates a stop codon.; Remark: the involvement of the pro1(+) gene in fruiting body development was confirmed by trying to complement the mutant phenotype with in vitro mutagenized and shortened versions of the pro1 open reading frame. Southern hybridization experiments also indicated that pro1(+) homologues are present in other sexually propagating filamentous ascomycetes.; Title: strong similarity to C6 zinc finger transcription factor PRO1 - Sordaria macrospora [putative sequencing error]; putative sequencing error; See PMID 10224253; uncharacterized protein 1831349 4991144 An04g07400 Aspergillus niger uncharacterized protein XP_059603654.1 1829113 D 5061 CDS An04g07410 4991145 join(1832479..1833526,1833587..1833687) VI 1 NT_166539.1 Remark: only the N-terminal domain is matching al the homologues. All other found homologues proeteins are approximately 300 amino acids longer.; Remark: similarity to the N-terminal of novel protein kinase, SEQ ID NO: 160 patent WO200073469-A2 - Homo sapiens.; Title: similarity to N-terminal of novel protein kinase SEQ ID NO:160 from patent WO200073469-A2 - Homo sapiens; uncharacterized protein 1833687 4991145 An04g07410 Aspergillus niger uncharacterized protein XP_001402102.1 1832479 D 5061 CDS An04g07420 84590968 join(1834858..1834942,1835033..1835100,1835147..1835221,1835275..1835356,1835414..1835641,1835705..1835879,1836065..1836256,1836304..1836538) VI 1 NT_166539.1 hypothetical protein 1836538 84590968 An04g07420 Aspergillus niger hypothetical protein XP_059603655.1 1834858 D 5061 CDS An04g07430 4991147 1837134..1837793 VI 1 NT_166539.1 Remark: the EST an_3432 from Aspergillus niger also overlapps with this sequence in the 3' region.; Similarity: the ORF shows strong similarity to the A. niger EST an_2117.; Title: similarity to hypothetical protein encoded by An07g09430 - Aspergillus niger; uncharacterized protein 1837793 4991147 An04g07430 Aspergillus niger uncharacterized protein XP_001402104.1 1837134 D 5061 CDS An04g07435 84590969 join(1840907..1840994,1841197..1841268,1841332..1841405) VI 1 NT_166539.1 hypothetical protein 1841405 84590969 An04g07435 Aspergillus niger hypothetical protein XP_059603656.1 1840907 D 5061 CDS An04g07440 4991149 complement(join(1844218..1844334,1844356..>1844817)) VI 1 NT_166539.1 Function: SHR3 of S. cerevisiae is a chaperone initiating ER-derived transport vesicle formation and thus allowing the ER-export of multiple amino acid permeases.; Remark: SHR3 of S. cerevisiae is also called D1022 and YDL212w.; Remark: SHR3 of S. cerevisiae is an integral membrane protein component of the endoplasmic reticulum.; Remark: the ORF is N-terminally truncated due to it's location at the end of the contig.; Title: similarity to endoplasmic reticulum membrane protein Shr3 - Saccharomyces cerevisiae [truncated ORF]; See PMID 1423607; See PMID 10564255; See PMID 11069779; uncharacterized protein 1844817 4991149 An04g07440 Aspergillus niger uncharacterized protein XP_059603657.1 1844218 R 5061 CDS An04g07450 84590970 join(<1844918..1844982,1845175..1845298) VI 1 NT_166539.1 Remark: the ORF is N-terminally truncated due to contig border.; Title: questionable ORF [truncated ORF]; uncharacterized protein 1845298 84590970 An04g07450 Aspergillus niger uncharacterized protein XP_059600634.1 1844918 D 5061 CDS An04g07460 4991151 complement(join(1845396..1847210,1847279..1847743)) VI 1 NT_166539.1 Function: the A. nidulans palFp protein is part of the pal pH signalling pathway which includes palA, palB,the pacC transcription factor, mediating regulation of gene expression by ambient pH, and a membrane sensor palI.; Title: strong similarity to ambiental pH regulatory system protein palFp - Aspergillus nidulans; See PMID 9272857; See PMID 9791171; See PMID 10476033; See PMID 10821185; uncharacterized protein 1847743 4991151 An04g07460 Aspergillus niger uncharacterized protein XP_059600635.1 1845396 R 5061 CDS An04g07470 4991152 complement(join(1849063..1849118,1849241..1849281,1849430..1849995,1850202..1850204)) VI 1 NT_166539.1 Title: similarity to hypothetical coiled-coil protein SPAC13A11.03 - Schizosaccharomyces pombe; uncharacterized protein 1850204 4991152 An04g07470 Aspergillus niger uncharacterized protein XP_059600636.1 1849063 R 5061 CDS An04g07480 4991153 complement(join(1852222..1852681,1852728..1853316,1853368..1853509)) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein CAD70809.1 - Neurospora crassa; uncharacterized protein 1853509 4991153 An04g07480 Aspergillus niger uncharacterized protein XP_001402110.3 1852222 R 5061 CDS An04g07490 4991154 1854105..1855295 VI 1 NT_166539.1 Function: human CSA protein interacts with CSB protein and with p44 protein, a subunit of the human RNA polymerase II transcription factor IIH suggesting a function in transcription. .; Title: similarity to Cockayne syndrome group A gene CSA - Homo sapiens; See PMID 7664335; uncharacterized protein 1855295 4991154 An04g07490 Aspergillus niger uncharacterized protein XP_001402111.3 1854105 D 5061 CDS An04g07500 4991155 complement(1855410..1855835) VI 1 NT_166539.1 Title: strong similarity to EST an_2778 -Aspergillus niger; uncharacterized protein 1855835 4991155 An04g07500 Aspergillus niger uncharacterized protein XP_001402112.1 1855410 R 5061 CDS An04g07510 4991156 complement(join(1856712..1857141,1857202..1857785,1857849..1857955,1858035..1858269)) VI 1 NT_166539.1 Title: strong similarity to monocarboxylate transporter MCT3 - Homo sapiens; uncharacterized protein 1858269 4991156 An04g07510 Aspergillus niger uncharacterized protein XP_001402113.1 1856712 R 5061 CDS An04g07530 4991158 complement(1859547..1863761) VI 1 NT_166539.1 Remark: blastp matches are not significant.; hypothetical protein 1863761 4991158 An04g07530 Aspergillus niger hypothetical protein XP_001402115.1 1859547 R 5061 CDS An04g07540 4991159 complement(join(1864914..1865030,1865086..1865207,1865494..1865812)) VI 1 NT_166539.1 Title: weak similarity to serine/threonine kinase Ste20 - Saccharomyces cerevisiae; See PMID 7608157; uncharacterized protein 1865812 4991159 An04g07540 Aspergillus niger uncharacterized protein XP_001402116.3 1864914 R 5061 CDS An04g07550 84590971 complement(join(1866542..1866602,1866963..1867077,1867505..1867586)) VI 1 NT_166539.1 Title: questionable ORF; uncharacterized protein 1867586 84590971 An04g07550 Aspergillus niger uncharacterized protein XP_059600637.1 1866542 R 5061 CDS An04g07555 84590972 join(1868912..1868959,1869038..1869196) VI 1 NT_166539.1 hypothetical protein 1869196 84590972 An04g07555 Aspergillus niger hypothetical protein XP_059600638.1 1868912 D 5061 CDS An04g07560 84590973 join(1869935..1870706,1870791..1871914) VI 1 NT_166539.1 Remark: Patentmatch against protein AC W37811 Genesqprot.; Title: weak similarity to Myb1 protein from patent WO9813486-A1 - Nicotiana tabacum; uncharacterized protein 1871914 84590973 An04g07560 Aspergillus niger uncharacterized protein XP_059600639.1 1869935 D 5061 CDS An04g07580 84590974 complement(join(1872701..1872877,1872910..1872921)) VI 1 NT_166539.1 hypothetical protein 1872921 84590974 An04g07580 Aspergillus niger hypothetical protein XP_059600640.1 1872701 R 5061 CDS An04g07590 84590975 complement(join(1873800..1874789,1874831..1874959)) VI 1 NT_166539.1 Remark: similarity corresponds to a short domain.; Title: weak similarity to erythrocyte membrane protein EMP1 - Plasmodium falciparum; See PMID 10838226; uncharacterized protein 1874959 84590975 An04g07590 Aspergillus niger uncharacterized protein XP_059600641.1 1873800 R 5061 CDS An04g07595 84590976 complement(join(1875856..1876188,1876400..1876489)) VI 1 NT_166539.1 Title: similarity to protein encoded by ORF1 of transposon Ant1 - Aspergillus niger; See PMID 8552048; uncharacterized protein 1876489 84590976 An04g07595 Aspergillus niger uncharacterized protein XP_059600642.1 1875856 R 5061 CDS An04g07600 84590977 join(1878160..1878329,1878466..1878499) VI 1 NT_166539.1 Remark: similarities correspond to a short domain.; Title: questionable ORF; uncharacterized protein 1878499 84590977 An04g07600 Aspergillus niger uncharacterized protein XP_059600643.1 1878160 D 5061 CDS An04g07610 84590978 join(1881124..1881254,1881547..1881598,1881821..1881831,1881899..1881968,1882176..1882255,1882762..1882841,1883034..1883125,1883183..1883453,1883511..1883864,1883920..1883955,1884345..1885183) VI 1 NT_166539.1 hypothetical protein 1885183 84590978 An04g07610 Aspergillus niger hypothetical protein XP_059600644.1 1881124 D 5061 CDS An04g07620 84590979 complement(join(1885812..1886096,1886671..1886772,1886932..1886994,1887081..1887156,1887291..1887324,1887431..1887471,1887571..1887666,1887755..1887822,1887928..1887978,1888060..1888105,1888174..1888274,1888350..1888406)) VI 1 NT_166539.1 Similarity: the ORF shows similarity only in the C-terminal region to the C-terminal region of An08g12070 of A. niger; Title: similarity to hypothetical protein encoded by An08g12070 - Aspergillus niger; uncharacterized protein 1888406 84590979 An04g07620 Aspergillus niger uncharacterized protein XP_059600645.1 1885812 R 5061 CDS An04g07630 84590980 complement(join(1888458..1888533,1888645..1888766,1889094..1889201,1889284..1889325)) VI 1 NT_166539.1 hypothetical protein 1889325 84590980 An04g07630 Aspergillus niger hypothetical protein XP_059600646.1 1888458 R 5061 CDS An04g07640 84590981 complement(join(<1892775..1892873,1892913..1893056,1893213..1893303,1893403..1893689)) VI 1 NT_166539.1 Remark: ORF 3'truncated due to end of contig.; Title: weak similarity to exo-alpha-sialidase TCNA -Trypanosoma cruzi [truncated ORF]; uncharacterized protein 1893689 84590981 An04g07640 Aspergillus niger uncharacterized protein XP_059603658.1 1892775 R 5061 CDS An04g07650 84590982 complement(1895257..1895823) VI 1 NT_166539.1 Remark: the DNA-sequence of the predicted A. niger protein contains three stopcodons indicating possible sequencing errors or an inactive protein (pseudogene).; Similarity: S. pombe Ste11 and the predicted A. niger protein contain a high mobility group (HMG) box involved in DNA-binding.; Title: similarity to transcription factor ste11p -Schizosaccharomyces pombe [putative pseudogene]; nucleus; putative pseudogene; See PMID 1657709; 1895823 84590982 An04g07650 Aspergillus niger 1895257 R 5061 CDS An04g07670 84590983 1895993..1897624 VI 1 NT_166539.1 Remark: the reading frame for the predicted A. niger protein contains 36 stopcodons, hence it likely is a pseudogene.; Title: strong similarity to transposase Tan1 -Aspergillus niger [putative pseudogene]; putative pseudogene; 1897624 84590983 An04g07670 Aspergillus niger 1895993 D 5061 CDS An04g07680 4991173 complement(1898642..1900300) VI 1 NT_166539.1 Function: C. albicans Flu1 is an efflux transporter involved in drug resistance.; Remark: expression of the C. albicans FLU1 gene in S. cerevisiae mediated not only resistance to fluconazole but also to cycloheximide.; Similarity: C. albicans Flu1 is a multidrug efflux transporter gene of the major facilitator superfamily.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; plasma membrane; See PMID 11065353; uncharacterized protein 1900300 4991173 An04g07680 Aspergillus niger uncharacterized protein XP_001402128.1 1898642 R 5061 CDS An04g07690 84590984 complement(join(1901180..1901308,1901311..1901544,1901624..1901710,1901862..1902170)) VI 1 NT_166539.1 Title: strong similarity to arsenic resistance protein ArsH - Yersinia enterocolitica; See PMID 9006011; uncharacterized protein 1902170 84590984 An04g07690 Aspergillus niger uncharacterized protein XP_059603659.1 1901180 R 5061 CDS An04g07700 84590985 complement(join(1903971..1904096,1904320..1904508,1904619..1904771,1905111..1905269)) VI 1 NT_166539.1 Similarity: the ORF exhibits similarity only in the C-terminal region to the C-terminal region of An04g07800 from A. niger; Title: strong similarity to hypothetical protein encoded by An04g07800 - Aspergillus niger; uncharacterized protein 1905269 84590985 An04g07700 Aspergillus niger uncharacterized protein XP_059603660.1 1903971 R 5061 CDS An04g07710 84590986 complement(1906782..1907786) VI 1 NT_166539.1 Function: more than 400 proteins containing ankyrin-repeats are known and they carry out a wide variety of biological functions including cell-cycle regulation,cytoscelatal organisation and transcriptional regulation.; Function: the ankyrin-repeat mediates protein-protein interactions.; Similarity: similarity is from the ankyrin-repeat containing central region of the predicted A. niger protein to human ANK1, which is 1000 aa longer.; Title: similarity to erythrocyte ankyrin ANK1 - Homo sapiens; See PMID 10431175; uncharacterized protein 1907786 84590986 An04g07710 Aspergillus niger uncharacterized protein XP_059603661.1 1906782 R 5061 CDS An04g07720 4991177 join(1908347..1909178,1909800..1910473) VI 1 NT_166539.1 Function: more than 400 proteins containing ankyrin-repeats are known and they carry out a wide variety of biological functions including cell-cycle regulation,cytoscelatal organisation and transcriptional regulation.; Function: the ankyrin-repeat mediates protein-protein interactions.; Similarity: similarity is from the ankyrin-repeat containing predicted A. niger protein to mouse Ank3, which is 1400 aa longer.; Title: similarity to ankyrin 3 Ank3 - Mus musculus; See PMID 10431175; uncharacterized protein 1910473 4991177 An04g07720 Aspergillus niger uncharacterized protein XP_059603662.1 1908347 D 5061 CDS An04g07730 84590987 join(1911699..1911823,1912192..1912276,1912325..1912477) VI 1 NT_166539.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1912477 84590987 An04g07730 Aspergillus niger uncharacterized protein XP_059603663.1 1911699 D 5061 CDS An04g07740 4991179 complement(join(1913175..1913412,1913485..1913509,1913568..1914003)) VI 1 NT_166539.1 Title: similarity to hypothetical protein 15E6.200 -Neurospora crassa; uncharacterized protein 1914003 4991179 An04g07740 Aspergillus niger uncharacterized protein XP_059603664.1 1913175 R 5061 CDS An04g07750 84590988 join(1916169..1916176,1916310..1916367,1916635..1916836,1917104..1917216) VI 1 NT_166539.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1917216 84590988 An04g07750 Aspergillus niger uncharacterized protein XP_059603665.1 1916169 D 5061 CDS An04g07760 84590989 complement(join(1917682..1918182,1918235..1918378,1918466..1918510,1918564..1919415,1919499..1919553,1919605..1919708,1919798..1919929,1919982..1920224)) VI 1 NT_166539.1 hypothetical protein 1920224 84590989 An04g07760 Aspergillus niger hypothetical protein XP_059603666.1 1917682 R 5061 CDS An04g07770 84590990 join(1920270..1920506,1920594..1920657,1920767..1921095) VI 1 NT_166539.1 Title: weak similarity to core protein - Hepatitis C virus; uncharacterized protein 1921095 84590990 An04g07770 Aspergillus niger uncharacterized protein XP_059603667.1 1920270 D 5061 CDS An04g07780 84590991 complement(join(1921548..1921784,1921857..1922053,1922162..1922210)) VI 1 NT_166539.1 hypothetical protein 1922210 84590991 An04g07780 Aspergillus niger hypothetical protein XP_059603668.1 1921548 R 5061 CDS An04g07790 84590992 join(1922385..1922476,1922541..1922693,1922770..1922965) VI 1 NT_166539.1 hypothetical protein 1922965 84590992 An04g07790 Aspergillus niger hypothetical protein XP_059603669.1 1922385 D 5061 CDS An04g07800 4991185 join(1923196..1923237,1923300..1923586,1923642..1923855,1923908..1924096,1924126..1924170) VI 1 NT_166539.1 Similarity: the ORF shows strong similarity to the A. niger protein An08g11810. The similarity between the two proteins, however, is restricted to a stretch of only about 110 amino acids.; Title: strong similarity to hypothetical protein encoded by An08g11810 - Aspergillus niger; uncharacterized protein 1924170 4991185 An04g07800 Aspergillus niger uncharacterized protein XP_059603670.1 1923196 D 5061 CDS An04g07810 84590993 complement(join(1924561..1924787,1924951..1925158)) VI 1 NT_166539.1 hypothetical protein 1925158 84590993 An04g07810 Aspergillus niger hypothetical protein XP_059603671.1 1924561 R 5061 CDS An04g07820 84590994 join(1925883..1925951,1926059..1926152,1926193..1926414,1926546..1926667,1926765..1926884) VI 1 NT_166539.1 hypothetical protein 1926884 84590994 An04g07820 Aspergillus niger hypothetical protein XP_059603672.1 1925883 D 5061 CDS An04g07830 84590995 join(1926889..1927001,1927056..1927317,1927337..1927443,1927537..1927654) VI 1 NT_166539.1 hypothetical protein 1927654 84590995 An04g07830 Aspergillus niger hypothetical protein XP_059603673.1 1926889 D 5061 CDS An04g07840 84590996 complement(join(1927985..1928061,1928159..1928285,1928372..1928437,1928583..1928798,1928901..1929457,1929545..1929671,1930936..1931322)) VI 1 NT_166539.1 Similarity: the ORF shows strong similarity to the A. niger protein An03g03100. The ORF is much longer than An03g03100 (518 compared to 160 amino acids).; Title: weak similarity to metalloreductase freA -Aspergillus nidulans; uncharacterized protein 1931322 84590996 An04g07840 Aspergillus niger uncharacterized protein XP_059603674.1 1927985 R 5061 CDS An04g07850 84590997 join(1931714..1931758,1931890..1931985,1932076..1932260,1932334..1932559) VI 1 NT_166539.1 hypothetical protein 1932559 84590997 An04g07850 Aspergillus niger hypothetical protein XP_059603675.1 1931714 D 5061 CDS An04g07860 84590998 complement(join(1934786..1934857,1935201..1935452)) VI 1 NT_166539.1 hypothetical protein 1935452 84590998 An04g07860 Aspergillus niger hypothetical protein XP_059603676.1 1934786 R 5061 CDS An04g07870 84590999 join(<1938221..1938247,1938279..1938326) VI 1 NT_166539.1 hypothetical protein [truncated ORF] 1938326 84590999 An04g07870 Aspergillus niger hypothetical protein [truncated ORF] XP_059605262.1 1938221 D 5061 CDS An04g07880 84591000 complement(join(1939095..1939150,1939315..1939542,1939611..1939657,1939926..1940048,1940188..1940254,1940565..1940661)) VI 1 NT_166539.1 hypothetical protein 1940661 84591000 An04g07880 Aspergillus niger hypothetical protein XP_059605263.1 1939095 R 5061 CDS An04g07890 84591001 complement(join(1941208..1941336,1941384..1941513,1941662..1941733,1941785..1941928,1942061..1942146,1942198..1942314,1942456..1942496,1942557..1942632)) VI 1 NT_166539.1 Title: weak similarity to larvicidal toxin 42K protein - Bacillus sphaericus; uncharacterized protein 1942632 84591001 An04g07890 Aspergillus niger uncharacterized protein XP_059605264.1 1941208 R 5061 CDS An04g07900 84591002 join(1943526..1944229,1944278..1944638) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein encoded by An08g12080 - Aspergillus niger; uncharacterized protein 1944638 84591002 An04g07900 Aspergillus niger uncharacterized protein XP_059605265.1 1943526 D 5061 CDS An04g07910 84591003 complement(1946968..1948206) VI 1 NT_166539.1 Remark: more than 2000 copies of various Bombyx TRAS elements can accumulate within (TTAGG)(n) sequences as unusual but orderly tandem repeats.; Remark: the pseudogene contains several internal stop-codons, and might have a longer C-terminus.; Title: similarity to non-LTR retrotransposon TRAS3 -Bombyx mori [putative pseudogene]; putative pseudogene; See PMID 11319268; 1948206 84591003 An04g07910 Aspergillus niger 1946968 R 5061 CDS An04g07920 84591004 join(1948235..1948330,1948401..1948506,1948666..1948866,1949198..1949391) VI 1 NT_166539.1 Title: weak similarity to hypothetical virulence factor encoded by ORF2929c - Pseudomonas aeruginosa; uncharacterized protein 1949391 84591004 An04g07920 Aspergillus niger uncharacterized protein XP_059605266.1 1948235 D 5061 CDS An04g07930 84591005 join(1950300..1950580,1950645..1950662,1950709..1950844) VI 1 NT_166539.1 Similarity: shows also some similarity to tropomyosin exons.; Title: weak similarity to hypothetical protein 29 -Bacillus phage phi105; uncharacterized protein 1950844 84591005 An04g07930 Aspergillus niger uncharacterized protein XP_059605267.1 1950300 D 5061 CDS An04g07940 84591006 join(1951303..1951512,1951622..1951831) VI 1 NT_166539.1 hypothetical protein 1951831 84591006 An04g07940 Aspergillus niger hypothetical protein XP_059605268.1 1951303 D 5061 CDS An04g07950 84591007 join(1952050..1952220,1952353..1952460,1952503..1952559) VI 1 NT_166539.1 hypothetical protein 1952559 84591007 An04g07950 Aspergillus niger hypothetical protein XP_059605269.1 1952050 D 5061 CDS An04g07960 84591008 complement(join(1952758..1952808,1952891..1952970,1953055..1953134,1953365..1953497,1953608..1953797)) VI 1 NT_166539.1 Similarity: the ORF shows similarity to the hypothetical A. niger protein An18g00170. The similarity between the two proteins is restricted to a stretch of about 100 amino acids.; Title: similarity to hypothetical protein encoded by An18g00170 - Aspergillus niger; uncharacterized protein 1953797 84591008 An04g07960 Aspergillus niger uncharacterized protein XP_059605270.1 1952758 R 5061 CDS An04g07970 84591009 join(1955331..1955708,1955847..1956150,1956216..1956397,1956510..1957122,1957182..1957591) VI 1 NT_166539.1 Function: Mx proteins have antiviral activities.; Induction: Mx proteins are induced by interferon n response to double-stranded RNA.; Similarity: Mx proteins belong to a GTPase family that includes rat dynamin, Drosophila Shibire and the yeast proteins Vps1/Spo15 and Mgm1.; Similarity: similarity is between the C-terminal regions of the predicted A. niger protein and M. musculus Mx, which is 200 aa shorter.; Title: similarity to antiviral GTPase Mx - Mus musculus; See PMID 7507812; uncharacterized protein 1957591 84591009 An04g07970 Aspergillus niger uncharacterized protein XP_059605271.1 1955331 D 5061 CDS An04g07980 84591010 complement(join(1958816..1959213,1959256..1959424)) VI 1 NT_166539.1 Remark: blastp shows significant similarity (46% positives) between the predicted A. niger protein and A. thaliana X74360 but due to shortness of both peptides the calculated probability is low (p=0,35).; Title: weak similarity to cDNA clone X74360 from patent FR2768746-A1 - Arabidopsis thaliana; uncharacterized protein 1959424 84591010 An04g07980 Aspergillus niger uncharacterized protein XP_059605272.1 1958816 R 5061 CDS An04g07990 84591011 complement(join(1964605..1964652,1964730..1964821,1964931..1964959,1965040..1965068,1965414..1965645,1965699..1966070,1966125..1966237,1966290..1966298)) VI 1 NT_166539.1 Remark: blastp with the predicted A. niger protein only retrieves random hits to serine and threonine rich proteins.; Similarity: the ORF shows strong similarity to the hypothetical A. niger protein An08g11870. The similarity between the two proteins extends only over a stretch of about 230 amino acids.; Title: strong similarity to hypothetical protein encoded by An08g11870 - Aspergillus niger; uncharacterized protein 1966298 84591011 An04g07990 Aspergillus niger uncharacterized protein XP_059605273.1 1964605 R 5061 CDS An04g08000 84591012 complement(join(1970688..1970767,1970861..1971034,1971174..1971629,1971732..1972052,1972109..1972467,1972675..1973132,1973189..1973402,1973466..1973644)) VI 1 NT_166539.1 Title: weak similarity to hypothetical protein encoded by An19g00010 - Aspergillus niger; uncharacterized protein 1973644 84591012 An04g08000 Aspergillus niger uncharacterized protein XP_059605274.1 1970688 R 5061 CDS An04g08020 4991206 complement(join(1977116..1977316,1977372..1977485,1977538..1977649,1977702..1978177)) VI 1 NT_166539.1 Similarity: C. tropicalis ARD belongs to the short-chain dehydrogenases family.; Title: strong similarity to NAD-dependent D-arabinitol dehydrogenase ard - Candida tropicalis; uncharacterized protein 1978177 4991206 An04g08020 Aspergillus niger uncharacterized protein XP_001402160.1 1977116 R 5061 CDS An04g08030 4991207 join(1978946..1979073,1979124..1979243,1979298..1979506,1979559..1979605,1979654..1979708,1979761..1979879,1979935..1980201,1980252..1980373,1980426..1980598,1980648..1980713,1980760..1980840,1980887..1981083) VI 1 NT_166539.1 Repression: high concentrations of glucose lead to the redistribution of S. cerevisiae HEX2 to the vacuole.; Repression: low-glucose-induced expression of S. cerevisiae HEX2 is mediated by two independent repression mechanisms, in the absence of glucose, transcription is prevented by Rgt1p, a C6 zinc cluster protein; at high levels of glucose, expression is repressed by Mig1p.; Title: strong similarity to hexose transporter Hxt2 - Saccharomyces cerevisiae; plasma membrane; See PMID 8816466; See PMID 10191260; uncharacterized protein 1981083 4991207 An04g08030 Aspergillus niger uncharacterized protein XP_001402161.3 1978946 D 5061 CDS An04g08040 4991208 join(1981362..1981479,1981568..1981662,1981742..1981756,1981793..1982536,1982581..1982833,1982886..1983005,1983109..1983358,1983604..1983686,1983795..1983853,1983939..1984181) VI 1 NT_166539.1 Similarity: simialrity is from the Zn(2)-Cys(6) DNA-binding domain containing N-terminal region of the predicted A. niger protein to the Zn(2)-Cys(6) DNA-binding domain of several putative and validated transcription factors.; Title: similarity to transcription factor Mpp1p -Pichia angusta; See PMID 12902346; uncharacterized protein 1984181 4991208 An04g08040 Aspergillus niger uncharacterized protein XP_059603677.1 1981362 D 5061 CDS An04g08050 4991209 complement(join(1984822..1984832,1984929..1985286,1985497..1985691)) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein encoded by An02g13120 - Aspergillus niger; uncharacterized protein 1985691 4991209 An04g08050 Aspergillus niger uncharacterized protein XP_001402163.3 1984822 R 5061 CDS An04g08060 84591013 join(1986007..1986281,1986381..1986738) VI 1 NT_166539.1 Remark: blastp with the predicted A. niger protein only retrieves random hits to proline and threonine rich proteins.; hypothetical protein 1986738 84591013 An04g08060 Aspergillus niger hypothetical protein XP_059603678.1 1986007 D 5061 CDS An04g08070 4991211 complement(join(1986896..1986953,1987095..1987294,1987347..1989416)) VI 1 NT_166539.1 Function: N. crassa qa-1S is a negative regulator for the initial events in quinate/shikimate metabolism as a carbon source.; Function: in N. crassa the qa activator and repressor proteins and the inducer quinic acid interact to control expression at the transcriptional level of all the qa genes.; Function: indirect evidence suggests that the N. crassa qa-1S repressor is not a DNA-binding protein but forms an inactive complex with the activator in the absence of the inducer.; Remark: the adjacent genomic region contains a predicted A. niger proteins with similarity to another regulatory gene of the quinate/shikimate metabolism gene cluster from N. crassa.; Similarity: the predicted A. niger protein contains a Shikimate kinase and a Shikimate / quinate 5-dehydrogenase domain and is 150 aa shorter than N. crassa qa-1S.; Similarity: the qa-1S repressor protein of N. crassa is strongly homologous to the pentafunctional arom enzyme found in many lower eukaryotes.; Title: similarity to negative regulator qa-1S -Neurospora crassa; See PMID 1825499; See PMID 2525625; See PMID 2960822; uncharacterized protein 1989416 4991211 An04g08070 Aspergillus niger uncharacterized protein XP_001402165.3 1986896 R 5061 CDS An04g08080 4991212 join(1989631..1991531,1991579..1991675) VI 1 NT_166539.1 Function: N. crassa qa-1F is a positive regulator for the five structural proteins mediating the initial events in quinate/shikimate metabolism as a carbon source.; Remark: the adjacent genomic region contains a predicted A. niger proteins with similarity to another regulatory gene of the quinate/shikimate metabolism gene cluster from N. crassa.; Similarity: the predicted A. niger protein contains a fungal Gal4 type Zn(2)-Cys(6) DNA-binding domain and is 150 aa shorter than N. crassa qa-1F.; Title: similarity to positive regulator qa-1F -Neurospora crassa; nucleus; See PMID 1825499; See PMID 2525625; uncharacterized protein 1991675 4991212 An04g08080 Aspergillus niger uncharacterized protein XP_001402166.1 1989631 D 5061 CDS An04g08090 4991213 complement(1991704..1992708) VI 1 NT_166539.1 Remark: the qa-4 gene of Neurospora crassa encodes 3-dehydroshikimate dehydratase, which catalyzes the third step of the quinic acid (qa) catabolic pathway.; Title: strong similarity to 3-dehydroshikimate dehydratase qa-4 - Neurospora crassa; See PMID 6241580; uncharacterized protein 1992708 4991213 An04g08090 Aspergillus niger uncharacterized protein XP_001402167.1 1991704 R 5061 CDS An04g08100 4991214 complement(1992892..1993815) VI 1 NT_166539.1 Catalytic activity: quinate + NAD+ = 5-dehydroquinate + NADH.; Pathway: first step of the quinic acid catabolic pathway; phenylalanine, tyrosine and tryptophan biosynthesis.; Remark: the QUTB sequence shows significant homology with the shikimate dehydrogenase function of the complex AROM locus of Aspergillus nidulans, and with the QA-3 quinate dehydrogenase and QA-1S (repressor) genes of Neurospora crassa.; Title: strong similarity to quinate 5-dehydrogenase qutB - Aspergillus nidulans; See PMID 2976880; uncharacterized protein 1993815 4991214 An04g08100 Aspergillus niger uncharacterized protein XP_001402168.1 1992892 R 5061 CDS An04g08110 4991215 join(1994142..1994820,1994979..1995094) VI 1 NT_166539.1 Title: strong similarity to hypothetical pathogenicity protein PEP2 - Nectria haematococca; See PMID 11208022; uncharacterized protein 1995094 4991215 An04g08110 Aspergillus niger uncharacterized protein XP_001402169.3 1994142 D 5061 CDS An04g08120 4991216 1995348..1996232 VI 1 NT_166539.1 Remark: strong similarity to Corynebacterium glutamicum sequence 439 patent WO0100843-A/439.; Similarity: belongs to the shikimate 5-dehydrogenases.; Title: strong similarity to sequence 439 from patent WO0100843-A - Corynebacterium glutamicum; uncharacterized protein 1996232 4991216 An04g08120 Aspergillus niger uncharacterized protein XP_001402170.1 1995348 D 5061 CDS An04g08130 4991217 1997058..1997648 VI 1 NT_166539.1 hypothetical protein 1997648 4991217 An04g08130 Aspergillus niger hypothetical protein XP_001402171.1 1997058 D 5061 CDS An04g08140 84591014 join(1998253..1998316,1998368..1998899,1999199..1999203,1999387..1999448) VI 1 NT_166539.1 Remark: the similarity is only in a small asparagin rich domain.; Title: weak similarity to Ras guanine nucleotide exchange factor RasGEFB - Dictyostelium discoideum; uncharacterized protein 1999448 84591014 An04g08140 Aspergillus niger uncharacterized protein XP_059603679.1 1998253 D 5061 CDS An04g08150 4991219 join(2000504..2000570,2000633..2001039) VI 1 NT_166539.1 Title: strong similarity to EST an_2637 -Aspergillus niger; uncharacterized protein 2001039 4991219 An04g08150 Aspergillus niger uncharacterized protein XP_001402173.1 2000504 D 5061 CDS An04g08160 4991220 join(2002024..2002125,2002187..2002676,2002863..2003160,2003192..2003711) VI 1 NT_166539.1 Title: weak similarity to hypothetical protein F37C4.5 - Caenorhabditis elegans; uncharacterized protein 2003711 4991220 An04g08160 Aspergillus niger uncharacterized protein XP_001402174.3 2002024 D 5061 CDS An04g08170 84591015 complement(join(2004822..2004886,2004966..2005041,2005113..2005166,2005263..2005341,2005428..2005528)) VI 1 NT_166539.1 hypothetical protein 2005528 84591015 An04g08170 Aspergillus niger hypothetical protein XP_059603680.1 2004822 R 5061 CDS An04g08180 84591016 join(2005854..2006074,2006165..2006249,2006326..2006525,2006546..2006718,2007094..2007202,2007301..2007361) VI 1 NT_166539.1 Title: weak similarity to disintegrin-like metalloproteinase splice form 1 ADAM11 - Homo sapiens; uncharacterized protein 2007361 84591016 An04g08180 Aspergillus niger uncharacterized protein XP_059603681.1 2005854 D 5061 CDS An04g08190 4991223 2007699..2008172 VI 1 NT_166539.1 Catalytic activity: ATP + H2O = ADP + orthophosphate.; Pathway: oxidative phosphorylation; photosynthesis.; Remark: a group of membrane-bound multi-subunit complexes in mitochondria, chloroplasts and bacteria in which ATP hydrolysis is coupled with transport of protons. In sealed vesicles the ATPase acticity is latent, unless a proton ionophore is available to discharge the proton gradient; these enzymes do not form a stable phosphoenzyme intermediate. Water-soluble subunit complexes (F1-CF1) can be extracted from these membrane-bound enzymes, which retain the ATPase activity but not the proton-transporting activity.; Remark: nearly identical to EST an_2903 from A. niger.; Similarity: belongs to the H+-transporting ATP synthase lipid-binding proteins. Remark:; Title: strong similarity to mitochondrial ATP synthase subunit 9 oliC31 - Aspergillus nidulans; See PMID 2880279; uncharacterized protein 2008172 4991223 An04g08190 Aspergillus niger uncharacterized protein XP_001402177.1 2007699 D 5061 CDS An04g08200 84591017 complement(join(2008459..2008608,2008675..2008834,2008964..2009042,2009264..2009343,2009455..2009480)) VI 1 NT_166539.1 hypothetical protein 2009480 84591017 An04g08200 Aspergillus niger hypothetical protein XP_059603682.1 2008459 R 5061 CDS An04g08210 4991225 join(2010205..2010514,2010696..2010773,2010849..2010997,2011102..2011391,2011562..2012051,2012094..2012357,2012475..2012552) VI 1 NT_166539.1 Catalytic activity: ATP + Pyruvate + H2O = AMP + Phosphoenolpyruvate + Orthophosphate.; Pathway: pyruvate metabolism; reductive carboxylate cycle (CO2 fixation).; Remark: the ppsA gene in E. coli codes for PEP synthase, which converts pyruvate into phosphoenolpyruvate (PEP), an essential step in gluconeogenesis when pyruvate or lactate are used as a carbon source.; Remark: this ORF is putative a pseudogene cause of more than 6 Frameshifts in the coding region.; Similarity: to other phosphoenolpyruvate synthases.; Title: strong similarity to pyruvate water dikinase ppsA - Escherichia coli [putative sequencing error]; putative sequencing error; See PMID 1310524; uncharacterized protein 2012552 4991225 An04g08210 Aspergillus niger uncharacterized protein XP_001402179.3 2010205 D 5061 CDS An04g08220 4991226 complement(join(2012671..2013344,2013435..2013684)) VI 1 NT_166539.1 Catalytic activity: (S)-lactate + NAD+ = pyruvate + NADH.; Pathway: glycolysis / gluconeogenesis; cysteine metabolism; pyruvate metabolism; propanoate metabolism.; Remark: ldhA codes for a 36-kDa protein that converts pyruvate to lactate. Production of LdhA was greatest when glucose was the carbon source, followed by xylose and trehalose; all of these sugars could be fermented to lactic acid.; Similarity: belongs to the family of malate/lactate dehydrogenases.; Title: strong similarity to lactate dehydrogenase ldhA - Rhizopus arrhizus; See PMID 10831409; uncharacterized protein 2013684 4991226 An04g08220 Aspergillus niger uncharacterized protein XP_001402180.1 2012671 R 5061 CDS An04g08230 84591018 join(2014773..2014825,2014893..2015037,2015167..2015238,2015294..2015515,2015546..2015872,2015926..2016091,2016148..2016329) VI 1 NT_166539.1 Catalytic activity: ATP + a protein = ADP + a phosphoprotein.; Remark: shows also strong similarity to Arabidopsis thaliana DNA fragment SEQ ID NO: 35384 patent EP1033405-A2.; Remark: the Arabidopsis gene, AFC1, induces three STE12-dependent processes even in signal transduction-defective yeast strains: mating-specific gene expression in haploid yeast, mating of haploid yeast to yield diploids, and pseudohyphal growth in diploid yeast.; Similarity: belongs to the serine/threonine protein kinases.; Title: strong similarity to protein kinase AFC1 -Arabidopsis thaliana; deleted EC_number 2.7.1.37; See PMID 7991592; uncharacterized protein 2016329 84591018 An04g08230 Aspergillus niger uncharacterized protein XP_059603683.1 2014773 D 5061 CDS An04g08240 4991228 2016703..2017716 VI 1 NT_166539.1 Title: weak similarity to hypothetical protein CAF32051.1 - Neurospora crassa; uncharacterized protein 2017716 4991228 An04g08240 Aspergillus niger uncharacterized protein XP_001402182.1 2016703 D 5061 CDS An04g08250 4991229 complement(join(2017892..2019076,2019144..2019473)) VI 1 NT_166539.1 Remark: strong similarity to Acremonium chrysogenum gene involved in biosynthesis of cephalosporin C patent JP09009966-A.; Title: strong similarity to protein involved in cephalosporin C biosynthesis from patent JP09009966-A -Acremonium chrysogenum; uncharacterized protein 2019473 4991229 An04g08250 Aspergillus niger uncharacterized protein XP_001402183.1 2017892 R 5061 CDS An04g08260 84591019 complement(join(2019678..2019742,2019834..2019922,2020081..2020122,2020239..2020359,2020488..2020661,2020811..2020898,2020988..2021047,2021140..2021192,2021352..2021582,2022071..2022245)) VI 1 NT_166539.1 Remark: weak similarity to Arabidopsis thaliana protein fragment SEQ ID NO:30705 patent EP1033405-A2; Title: weak similarity to protein fragment SEQ ID NO:30705 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 2022245 84591019 An04g08260 Aspergillus niger uncharacterized protein XP_059603684.1 2019678 R 5061 CDS An04g08270 84591020 join(2022751..2022764,2022811..2022838,2022974..2022993,2023311..2023453,2023751..2023856,2024209..2024407,2024453..2024620) VI 1 NT_166539.1 hypothetical protein 2024620 84591020 An04g08270 Aspergillus niger hypothetical protein XP_059603685.1 2022751 D 5061 CDS An04g08280 84591021 complement(join(2025209..2025260,2025305..2025546)) VI 1 NT_166539.1 hypothetical protein 2025546 84591021 An04g08280 Aspergillus niger hypothetical protein XP_059603686.1 2025209 R 5061 CDS An04g08290 4991233 complement(2026154..2027308) VI 1 NT_166539.1 Title: similarity to hypothetical protein EAA74627.1 - Gibberella zeae; uncharacterized protein 2027308 4991233 An04g08290 Aspergillus niger uncharacterized protein XP_001402187.1 2026154 R 5061 CDS An04g08300 4991234 complement(join(2027809..2029451,2029593..2029611)) VI 1 NT_166539.1 Remark: Among the four polyamine transporters in S. cerevisiae, those encoded by TPO2 and TPO3 were specific for spermine, whereas those encoded by TPO1 and TPO4 recognized spermidine and spermine.; Remark: alternative name is YGR138c; Similarity: belongs to the benomyl/methotrexate resistance protein family.; Title: strong similarity to membrane protein Tpo2 -Saccharomyces cerevisiae; vacuole; See PMID 11171066; uncharacterized protein 2029611 4991234 An04g08300 Aspergillus niger uncharacterized protein XP_001402188.3 2027809 R 5061 CDS An04g08310 84591022 complement(join(2029761..2029863,2029948..2030016,2030129..2030259,2030316..2030357)) VI 1 NT_166539.1 hypothetical protein 2030357 84591022 An04g08310 Aspergillus niger hypothetical protein XP_059603687.1 2029761 R 5061 CDS An04g08320 4991236 complement(join(2030768..2031283,2031373..2031539,2031643..2032153)) VI 1 NT_166539.1 Similarity: the ORF shows also similarity to a variety of monocarboxylate transporters.; Similarity: the ORF shows strong similarity to the A. niger EST SEQ ID NO:4112.; Title: strong similarity to protease Mch5 -Saccharomyces cerevisiae; See PMID 8755496; uncharacterized protein 2032153 4991236 An04g08320 Aspergillus niger uncharacterized protein XP_059603688.1 2030768 R 5061 CDS An04g08330 4991237 complement(2033119..>2033604) VI 1 NT_166539.1 Catalytic activity: orotidine 5'-phosphate + pyrophosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.; Pathway: pyrimidine metabolism.; Remark: N-terminal truncated ORF due to end of contig.; Remark: URA5 genes encode orotidine-5'-monophosphate pyrophosphorylase (OMPpase), an enzyme involved in pyrimidine biosynthesis.; Similarity: belongs to the orotate phosphoribosyltransferases.; Title: strong similarity to orotidine-5-monophosphate pyrophosphorylase - Ajellomyces capsulatus [truncated ORF]; See PMID 9748447; uncharacterized protein 2033604 4991237 An04g08330 Aspergillus niger uncharacterized protein XP_001402191.3 2033119 R 5061 CDS An04g08340 4991238 complement(join(2034033..2034381,2034443..2037744,2037793..2037987,2038044..2038085)) VI 1 NT_166539.1 Remark: also strong similarity to Aspergillus flavus multidrug resistance protein Afl-MDR1 patent WO9626952-A1.; Remark: expression of AFUMDR1 in S. cerevisiae conferred increased resistance to the antifungal agent cilofungin (LY121019), an echinocandin B analog.; Title: strong similarity to multidrug resistance protein mdr1 - Aspergillus flavus; plasma membrane; See PMID 9373135; uncharacterized protein 2038085 4991238 An04g08340 Aspergillus niger uncharacterized protein XP_001402192.1 2034033 R 5061 CDS An04g08350 84591023 join(2038371..2038451,2038510..2038746) VI 1 NT_166539.1 Title: weak similarity to glutamic acid release inhibitory peptide from patent JP07149795-A - Agelenopsis aperta; uncharacterized protein 2038746 84591023 An04g08350 Aspergillus niger uncharacterized protein XP_059600647.1 2038371 D 5061 CDS An04g08360 4991240 complement(join(2039146..2039469,2039531..2039906,2039961..2040516,2040566..2040635,2040691..2040786,2040833..2040919)) VI 1 NT_166539.1 Pathway: the TRI11 enzyme from F. sporotrichioides is involved trichothecene biosynthesis. Trichothecenes are sesquiterpenoid toxins that act by inhibiting protein biosynthesis.; Remark: disruption of TRI11 results in an altered trichothecene production phenotype characterized by the accumulation of isotrichodermin, a trichothecene pathway intermediate.; Similarity: TRI11 (F. s.) belongs to the cytochrome p450 family.; Title: strong similarity to cytochrome P450 monooxygenase TRI11 - Fusarium sporotrichioides; See PMID 9435078; uncharacterized protein 2040919 4991240 An04g08360 Aspergillus niger uncharacterized protein XP_001402194.1 2039146 R 5061 CDS An04g08370 4991241 join(2041743..2042293,2042343..2042984,2043035..2043431) VI 1 NT_166539.1 Catalytic activity: UDPgalactose + 2-(2-Hydroxyacyl)sphingosine = UDP + 1-(beta-D-Galactosyl)-2-(2-hydroxyacyl)sphingosine.; Remark: galactosylceramide (galactocerebroside,GalC) and its sulfated derivative, sulfatide, are major lipid components of the central and peripheral nervous system myelin sheath. The human enzyme UDP-galactose:ceramide galactosyltransferase (CGT, EC 2. 4. 1. 45) catalyzes the final step of galactosylceramide synthesis.; Similarity: belongs to the Glycosyl transferases,related to UDP-glucuronosyltransferases.; Title: similarity to ceramide UDPgalactosyltransferase CGT - Homo sapiens; See PMID 9125199; uncharacterized protein 2043431 4991241 An04g08370 Aspergillus niger uncharacterized protein XP_001402195.3 2041743 D 5061 CDS An04g08380 84591024 2043513..2044463 VI 1 NT_166539.1 Remark: strong similarity to Mortierella ramanni diacylglycerol acyl transferase MR1 patent WO200001713-A2.; Remark: the Mortierella ramanni MR1 enzyme is active in the formation of triacylglycerol from diacylglycerol and fatty acyl substrates. The DNA sequences encoding DAGAT can be used to modify the triacylglycerol and lipid composition of plant cells.; Title: strong similarity to diacylglycerol acyl transferase MR1 from patent WO200001713-A2 - Mortierella ramanniana; uncharacterized protein 2044463 84591024 An04g08380 Aspergillus niger uncharacterized protein XP_059600648.1 2043513 D 5061 CDS An04g08390 4991243 join(2045286..2045369,2045439..2045662,2045716..2046235,2046354..2046449) VI 1 NT_166539.1 Remark: introduction of extra copies of orf10 and orf11 genes in an S. coelicolor actIII mutant restores the ability to produce actinorhodin. Transcriptional analysis and DNA footprinting indicate that Orf10 represses its own transcription and regulates orf11 transcription.; Similarity: belongs to short-chain alcohol dehydrogenase with different specificities.; Title: strong similarity to oxidoreductase of short-chain ORF11 - Streptomyces coelicolor; See PMID 10400594; uncharacterized protein 2046449 4991243 An04g08390 Aspergillus niger uncharacterized protein XP_001402197.3 2045286 D 5061 CDS An04g08400 84591025 join(2046763..2047546,2047603..2047655) VI 1 NT_166539.1 Title: weak similarity to hypothetical possible CHE-2 homologue L4738.06 - Leishmania major; uncharacterized protein 2047655 84591025 An04g08400 Aspergillus niger uncharacterized protein XP_059600649.1 2046763 D 5061 CDS An04g08410 4991245 complement(2048427..2049983) VI 1 NT_166539.1 Catalytic activity: benzoate + NADPH + O2 = 4-hydroxybenzoate + NADP+ + H2O.; Pathway: phenylalanine metabolism.; Remark: Cytochrome P450 enzyme systems are found throughout nature and are involved in many different, often complex, bioconversions. In the endoplasmic reticulum of the filamentous fungus Aspergillus niger a cytochrome P450 enzyme system is present that is capable of the para-hydroxylation of benzoate. The expression of the two genes encoding the components of this system, the cytochrome P450 gene encoding benzoate para-hydroxylase (bphA) and the gene encoding cytochrome P450 reductase (cprA), are inducible by benzoate.; Similarity: belongs to the cytochrome P450 family.; Title: strong similarity to benzoate 4-monooxygenase cytochrome P450 53 bphA - Aspergillus niger; See PMID 10852481; See PMID 2250647; uncharacterized protein 2049983 4991245 An04g08410 Aspergillus niger uncharacterized protein XP_001402199.1 2048427 R 5061 CDS An04g08420 4991246 join(2050810..2050832,2051068..2051081,2051235..2051384,2051443..2051717,2051774..2052086,2052160..2052803,2052972..2052986) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein CAD21260.1 - Neurospora crassa; uncharacterized protein 2052986 4991246 An04g08420 Aspergillus niger uncharacterized protein XP_059600650.1 2050810 D 5061 CDS An04g08430 4991247 complement(join(2053450..2053478,2053558..2053807)) VI 1 NT_166539.1 hypothetical protein 2053807 4991247 An04g08430 Aspergillus niger hypothetical protein XP_001402201.1 2053450 R 5061 CDS An04g08440 4991248 complement(join(2055219..2055406,2055479..2055580,2055639..2055943,2055993..2057065)) VI 1 NT_166539.1 Pathway: the TRI11 enzyme from F. sporotrichioides is involved trichothecene biosynthesis. Trichothecenes are sesquiterpenoid toxins that act by inhibiting protein biosynthesis.; Remark: disruption of TRI11 results in an altered trichothecene production phenotype characterized by the accumulation of isotrichodermin, a trichothecene pathway intermediate.; Similarity: TRI11 (F. s.) belongs to the cytochrome p450 family.; Title: strong similarity to cytochrome P450 monooxygenase TRI11 - Fusarium sporotrichioides; See PMID 9435078; uncharacterized protein 2057065 4991248 An04g08440 Aspergillus niger uncharacterized protein XP_059600651.1 2055219 R 5061 CDS An04g08450 84591026 join(2057225..2057240,2057327..2057438,2057921..2058006,2058714..2059012) VI 1 NT_166539.1 Title: questionable ORF; uncharacterized protein 2059012 84591026 An04g08450 Aspergillus niger uncharacterized protein XP_059600652.1 2057225 D 5061 CDS An04g08460 4991250 complement(join(2059409..2060174,2060230..2060369)) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein SPBC365.16 - Schizosaccharomyces pombe; uncharacterized protein 2060369 4991250 An04g08460 Aspergillus niger uncharacterized protein XP_001402204.1 2059409 R 5061 CDS An04g08470 84591027 complement(join(2060885..2061328,2061381..2061419)) VI 1 NT_166539.1 Title: weak similarity to hypothetical protein Vng6427h - Halobacterium sp.; uncharacterized protein 2061419 84591027 An04g08470 Aspergillus niger uncharacterized protein XP_059600653.1 2060885 R 5061 CDS An04g08480 4991252 complement(join(2061807..2061926,2061980..2062259,2062328..2062497,2062561..2062581)) VI 1 NT_166539.1 Remark: YKT6 is an essential gene that codes for a novel vesicle-associated SNARE functioning at the endoplasmic reticulum-Golgi transport step in the yeast secretory pathway. Depletion of Ykt6p results in the accumulation of the p1 precursor (endoplasmic reticulum form) of the vacuolar enzyme carboxypeptidase Y and morphological abnormalities consistent with a defect in secretion. Bet1p, p28, and p14) suggests that multimeric interactions are features of the fusion machinery, and may also improve the fidelity of vesicle targeting.; Remark: alternative names is YKT6.; Title: strong similarity to cell division control protein SLY2 homolog YKL196c - Saccharomyces cerevisiae; See PMID 7923363; See PMID 9211930; uncharacterized protein 2062581 4991252 An04g08480 Aspergillus niger uncharacterized protein XP_059600654.1 2061807 R 5061 CDS An04g08490 4991253 join(2063188..2063305,2063454..2063875,2063928..2064413) VI 1 NT_166539.1 Title: similarity to essential gene protein #54 from patent WO200286090-A2 - Aspergillus fumigatus; uncharacterized protein 2064413 4991253 An04g08490 Aspergillus niger uncharacterized protein XP_059600655.1 2063188 D 5061 CDS An04g08500 4991254 join(2064792..2065089,2065138..2065223,2065280..2065336) VI 1 NT_166539.1 Remark: rodA encodes a small, moderately hydrophobic polypeptide containing 8 cysteines arranged in a pattern similar to that observed in three hydrophobic cell wall proteins from the Holobasidiomycete Schizophyllum commune. The Aspergillus and Schizophyllum 8-cysteine polypeptides define a class of secreted, hydrophobic, fungal cell wall proteins that are important in the formation and function of aerial structures such as conidiophores and mushrooms.; Title: strong similarity to rodletless protein rodA - Aspergillus nidulans; See PMID 2065971; uncharacterized protein 2065336 4991254 An04g08500 Aspergillus niger uncharacterized protein XP_001402208.1 2064792 D 5061 CDS An04g08510 4991255 complement(join(2065886..2066434,2066493..2066552,2066627..2066759,2066829..2067038,2067107..2067480)) VI 1 NT_166539.1 Remark: CYP3A9 cDNA was expressed in E. coli and the expressed P450 3A9 is active in the demethylation of erythromycin as well as benzphetamine.; Title: similarity to cytochrome P450 3A9 CYP3A -Rattus norvegicus; See PMID 8660328; uncharacterized protein 2067480 4991255 An04g08510 Aspergillus niger uncharacterized protein XP_059600656.1 2065886 R 5061 CDS An04g08520 84591028 join(2068917..2069394,2069436..2069618,2069685..2069944) VI 1 NT_166539.1 Title: weak similarity to hypothetical protein EAA78112.1 - Gibberella zeae; uncharacterized protein 2069944 84591028 An04g08520 Aspergillus niger uncharacterized protein XP_059600657.1 2068917 D 5061 CDS An04g08530 84591029 complement(join(2070268..2070378,2070462..2070572)) VI 1 NT_166539.1 Remark: the ORF is short in length (73 amino acids).; hypothetical protein 2070572 84591029 An04g08530 Aspergillus niger hypothetical protein XP_059600658.1 2070268 R 5061 CDS An04g08540 84591030 complement(join(2074746..2074798,2074992..2075147,2075227..2075341)) VI 1 NT_166539.1 hypothetical protein 2075341 84591030 An04g08540 Aspergillus niger hypothetical protein XP_059600659.1 2074746 R 5061 CDS An04g08550 4991259 complement(2076390..2077700) VI 1 NT_166539.1 Catalytic activity: endohydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.; Pathway: starch and sucrose metabolism.; Remark: expression of the T. reesei cDNA in yeast showed that it encoded a protein with endoglucanase activity; Title: strong similarity to endoglucanase IV EGIV -Trichoderma reesei; uncharacterized protein 2077700 4991259 An04g08550 Aspergillus niger uncharacterized protein XP_059600660.1 2076390 R 5061 CDS An04g08560 4991260 complement(join(2078803..2078916,2078963..2079063,2079144..2079813,2079886..2080391,2080459..2080591)) VI 1 NT_166539.1 Catalytic activity: (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c.; Pathway: pyruvate metabolism.; Remark: analysis of KlCYB2 gene expression indicated that, in contrast to S. cerevisiae, the major regulatory feature is induction by lactate.; Similarity: belongs to the L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases.; Title: strong similarity to cytochrome b2 cyb2 -Kluyveromyces lactis; See PMID 10806428; uncharacterized protein 2080591 4991260 An04g08560 Aspergillus niger uncharacterized protein XP_059600661.1 2078803 R 5061 CDS An04g08570 84591031 join(2080693..2080752,2080801..2080853,2080924..2081006,2081102..2081268) VI 1 NT_166539.1 hypothetical protein 2081268 84591031 An04g08570 Aspergillus niger hypothetical protein XP_059600662.1 2080693 D 5061 CDS An04g08580 4991262 complement(2081436..2083763) VI 1 NT_166539.1 Remark: its functions of binding ATP and of autophosphorylation and eIF-2 alpha phosphorylation are inhibited by hemin.; Title: strong similarity to translation initiation factor eIF-2 alpha chain kinase HRI - Oryctolagus cuniculus; See PMID 1671169; See PMID 1679235; uncharacterized protein 2083763 4991262 An04g08580 Aspergillus niger uncharacterized protein XP_059600663.1 2081436 R 5061 CDS An04g08590 4991263 join(2085477..2086687,2086745..2087288) VI 1 NT_166539.1 Catalytic activity: cyclobutadipyrimidine (in DNA) = 2 pyrimidine (in DNA).; Remark: photolyases and blue light receptors belong to a superfamily of flavoproteins that make use of blue and UVA light either to catalyze DNA repair or to control development.; Similarity: belongs to the deoxyribodipyrimidine photo-lyases.; Title: strong similarity to DNA photolyase phr1 -Trichoderma harzianum; See PMID 10318850; uncharacterized protein 2087288 4991263 An04g08590 Aspergillus niger uncharacterized protein XP_001402217.1 2085477 D 5061 CDS An04g08600 4991264 join(2089184..2090415,2090469..2091735) VI 1 NT_166539.1 Remark: the transcriptional activator XlnR regulates the transcription of the xlnB, xlnC, and xlnD genes encoding the main xylanolytic enzymes (endoxylanases B and C and beta-xylosidase, respectively). Also, the transcription of the genes encoding the accessory enzymes involved in xylan degradation, including alpha-glucuronidase A, acetylxylan esterase A, arabinoxylan arabinofuranohydrolase A, and feruloyl esterase A, was found to be controlled by XlnR. In addition, XlnR also activates transcription of two endoglucanase-encoding genes, eglA and eglB, indicating that transcriptional regulation by XlnR goes beyond the genes encoding xylanolytic enzymes and includes regulation of two endoglucanase-encoding genes.; Similarity: belongs to the GAL4 zinc binuclear cluster proteins.; Title: strong similarity to transcription activator xlnR - Aspergillus niger; See PMID 9758775; See PMID 10760176; See PMID 9466262; uncharacterized protein 2091735 4991264 An04g08600 Aspergillus niger uncharacterized protein XP_059600664.1 2089184 D 5061 CDS An04g08610 4991265 join(2093080..2093369,2093452..2094154) VI 1 NT_166539.1 hypothetical protein 2094154 4991265 An04g08610 Aspergillus niger hypothetical protein XP_001402219.1 2093080 D 5061 CDS An04g08620 4991266 complement(join(2096467..2096607,2096656..2097020,2097081..2097453,2097583..2097705)) VI 1 NT_166539.1 Remark: Hap1 S. cerevisiae binds to two classes of DNA elements, UAS1/CYC1 and UAS/CYC7, and permits differential transcriptional activation at these sites. In yeast, oxygen sensing and heme signaling are primarily mediated by the heme activator protein Hap1, which, in response to heme, activates the transcription of genes required for respiration and for controlling oxidative damage.; Similarity: belongs to the unassigned GAL4-type zinc cluster proteins; GAL4 zinc binuclear cluster homology.; Title: similarity to heme activator protein Hap1 -Saccharomyces cerevisiae; See PMID 10617612; See PMID 11212295; See PMID 2643482; uncharacterized protein 2097705 4991266 An04g08620 Aspergillus niger uncharacterized protein XP_059600665.1 2096467 R 5061 CDS An04g08630 4991267 complement(2100778..2101761) VI 1 NT_166539.1 Function: a ketone is treated with a transaminase in the presence of a primary amine as amino donor to produce the amines.; Function: the chiral amines are synthetic intermediates for use as pharmaceuticals and agrochemicals.; Function: the present sequence represents a protein with stereoselective transaminase activity.; Function: the transaminase is used to produce the optically active amines (having R-chirality) of the invention.; Remark: protein sequence of patentprot.; Title: strong similarity to protein with stereoselective transaminase activity from patent WO9848030-A1 - Arthrobacter sp.; uncharacterized protein 2101761 4991267 An04g08630 Aspergillus niger uncharacterized protein XP_059600666.1 2100778 R 5061 CDS An04g08640 4991268 join(2102746..2102772,2102884..2103259,2103316..2103681,2103735..2103825,2103864..2104554) VI 1 NT_166539.1 Title: similarity to hypothetical protein YER080w -Saccharomyces cerevisiae; uncharacterized protein 2104554 4991268 An04g08640 Aspergillus niger uncharacterized protein XP_059600667.1 2102746 D 5061 CDS An04g08650 4991269 2105427..2106344 VI 1 NT_166539.1 Function: aapA is a transmembrane protein and probably a aminoacid or metabolite transport protein.; Similarity: shows only partial similarity to aapA of B. subtilis.; Title: strong similarity to hypothetical protein encoded by An18g03630 - Aspergillus niger; uncharacterized protein 2106344 4991269 An04g08650 Aspergillus niger uncharacterized protein XP_001402223.1 2105427 D 5061 CDS An04g08660 4991270 complement(join(2106700..2107218,2107428..2107805)) VI 1 NT_166539.1 Similarity: blast hits result from repetitive sequences.; Title: weak similarity to hypothetical protein BAT2 - Homo sapiens; uncharacterized protein 2107805 4991270 An04g08660 Aspergillus niger uncharacterized protein XP_059600668.1 2106700 R 5061 CDS An04g08670 4991271 complement(join(2109155..2110108,2110159..2110827,2110885..2111040)) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein EAA61363.1- Aspergillus nidulans; uncharacterized protein 2111040 4991271 An04g08670 Aspergillus niger uncharacterized protein XP_059600669.1 2109155 R 5061 CDS An04g08680 4991272 complement(join(2111290..2111537,2111596..2112141,2112188..2112986)) VI 1 NT_166539.1 Function: CCA1 carries out addition of CCA to 3'-end of tRNA without a template.; Title: strong similarity to tRNA nucleotidyltransferase Cca1 - Saccharomyces cerevisiae; uncharacterized protein 2112986 4991272 An04g08680 Aspergillus niger uncharacterized protein XP_001402226.3 2111290 R 5061 CDS An04g08690 4991273 join(2113892..2114963,2115015..2116162) VI 1 NT_166539.1 Function: patented novel nucleic acids and peptides derived from open reading frame X, useful for treating e. g. cancers, proliferative disorders, neurodegenerative disorders and cardiovascular disease.; Similarity: shows similarity to hypothetical proteins of S. pombe, A. thaliana etc.; Title: similarity to polynucleotide sequence SEQ ID NO:3913 from patent WO200058473-A2 - Homo sapiens; uncharacterized protein 2116162 4991273 An04g08690 Aspergillus niger uncharacterized protein XP_059600670.1 2113892 D 5061 CDS An04g08700 4991274 join(2117321..2117367,2117434..2117680,2117756..2117974,2118042..2118992) VI 1 NT_166539.1 Title: similarity to hypothetical protein SPBC1604.18c - Schizosaccharomyces pombe; uncharacterized protein 2118992 4991274 An04g08700 Aspergillus niger uncharacterized protein XP_059600671.1 2117321 D 5061 CDS An04g08710 4991275 complement(join(2119070..2119727,2119784..2119898,2119949..2120450)) VI 1 NT_166539.1 Function: retransformation of uvsH77 mutants of A. nidulans with the rescued cosmids from the MMS-resistant transformants resulted in restoration of both UV and MMS resistance to wild-type levels.; Title: strong similarity to protein involved in DNA repair and recombination uvsH - Aspergillus nidulans; nucleus; uncharacterized protein 2120450 4991275 An04g08710 Aspergillus niger uncharacterized protein XP_001402229.1 2119070 R 5061 CDS An04g08720 4991276 join(2120746..2120805,2120850..2120923,2120987..2121231,2121293..2121471,2121530..2121835,2121891..2121915,2121968..2122105,2122151..2122336,2122371..2122402) VI 1 NT_166539.1 Title: similarity to hypothetical protein CAE85531.1 - Neurospora crassa; uncharacterized protein 2122402 4991276 An04g08720 Aspergillus niger uncharacterized protein XP_059600672.1 2120746 D 5061 CDS An04g08730 4991277 join(2123729..2123856,2123921..2125131,2125202..2125473) VI 1 NT_166539.1 Similarity: show strong similarity to conserved hypothetical proteins of several species.; Title: strong similarity to hypothetical conserved protein SPAC12B10.16c - Schizosaccharomyces pombe; uncharacterized protein 2125473 4991277 An04g08730 Aspergillus niger uncharacterized protein XP_001402231.1 2123729 D 5061 CDS An04g08740 4991278 complement(join(2125711..2125807,2125949..2127155,2127224..2127281)) VI 1 NT_166539.1 Function: Pas10p plays an important role in protein translocation across the peroxisome membrane.; Localization: Pas10p is an integral protein of the peroxisome membrane.; Title: strong similarity to peroxisome assembly protein PAS10 - Pichia pastoris; peroxisome; See PMID 8670828; uncharacterized protein 2127281 4991278 An04g08740 Aspergillus niger uncharacterized protein XP_059600673.1 2125711 R 5061 CDS An04g08750 84591032 complement(2127570..2129630) VI 1 NT_166539.1 Similarity: shows only partial similarity at the aminoterminus.; Title: strong similarity to hypothetical protein EAA61357.1 - Aspergillus nidulans; uncharacterized protein 2129630 84591032 An04g08750 Aspergillus niger uncharacterized protein XP_059600674.1 2127570 R 5061 CDS An04g08760 4991280 join(2129931..2129995,2130090..2131605) VI 1 NT_166539.1 Complex: NMD3 of S. cerevisiae associates with ribosomes.; Function: NMD3 is a component of the nonsense-mediated mRNA decay pathway.; Remark: NMD3 of S. cerevisiae is also known as SRC5 and has a systematic name of YHR170W.; Title: strong similarity to nonsense-mediated mRNA decay protein Nmd3 - Saccharomyces cerevisiae; cytoplasm; See PMID 9933353; See PMID 10022925; See PMID 10590466; uncharacterized protein 2131605 4991280 An04g08760 Aspergillus niger uncharacterized protein XP_001402234.1 2129931 D 5061 CDS An04g08770 84591033 join(2132742..2132876,2132926..2133291) VI 1 NT_166539.1 hypothetical protein 2133291 84591033 An04g08770 Aspergillus niger hypothetical protein XP_059600675.1 2132742 D 5061 CDS An04g08780 84591034 join(2133721..2133759,2133798..2134166) VI 1 NT_166539.1 hypothetical protein 2134166 84591034 An04g08780 Aspergillus niger hypothetical protein XP_059600676.1 2133721 D 5061 CDS An04g08790 4991283 complement(2134998..2135912) VI 1 NT_166539.1 Remark: patent describes novel nucleic acids and peptides derived from open reading frame X, useful for treating e. g. cancers, proliferative disorders,neurodegenerative disorders and cardiovascular disease.; Similarity: shows partial similarity to conserved hypothetical proteins of S. cerevisiae, S. pombe, etc and a human protein that might be a transcriptional regulator.; Title: similarity to ORFX ORF1691 polynucleotide sequence SEQ ID NO:3381 from patent WO200058473-A2 - Homo sapiens; uncharacterized protein 2135912 4991283 An04g08790 Aspergillus niger uncharacterized protein XP_001402237.3 2134998 R 5061 CDS An04g08800 4991284 complement(join(2136672..2137646,2137722..2138054)) VI 1 NT_166539.1 Function: Leu5p involved in the accumulation of CoA in mitochondria, presumably by serving as a transporter of CoA or a precursor thereof.; Localization: Leu5p of S. cerevisiae is inserted into the mitochondrial inner membrane along the specialized import pathway used by carrier proteins.; Phenotype: as a consequence, the activities of several mitochondrial CoA-dependent enzymes were strongly decreased in Deltaleu5 cells.; Phenotype: deletion of LEU5 (strain Deltaleu5) was accompanied by a 15-fold reduction of mitochondrial coenzyme A (CoA) levels but did not affect the cytosolic CoA content.; Title: strong similarity to mitochondrial carrier Leu5 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 11158296; uncharacterized protein 2138054 4991284 An04g08800 Aspergillus niger uncharacterized protein XP_001402238.1 2136672 R 5061 CDS An04g08810 4991285 complement(join(2138904..2139969,2140049..2141646,2141703..2141719,2141780..2141882,2141938..2142081,2142136..2142201,2142293..2142295)) VI 1 NT_166539.1 Function: protein of S. cerevisiae is a component of a complex involved in chromatin remodelling.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to subunit of Isw2 chromatin remodelling complex Itc1 - Saccharomyces cerevisiae; nucleus; See PMID 8840506; uncharacterized protein 2142295 4991285 An04g08810 Aspergillus niger uncharacterized protein XP_059600677.1 2138904 R 5061 CDS An04g08820 4991286 complement(join(2144561..2145085,2145137..2145276,2145332..2145825,2145883..2146076,2146142..2146220,2146300..2146571,2146712..2146750)) VI 1 NT_166539.1 Function: enzyme of S. cerevisiae is involved in adding glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein.; Pathway: enzyme of S. cerevisiae is involved in glycosylation.; Similarity: shows similarity to Alg6p, S. pombe and C. elegans hypothetical proteins.; Title: strong similarity to glucosyltransferase Alg8 - Saccharomyces cerevisiae; endoplasmatic reticulum; uncharacterized protein 2146750 4991286 An04g08820 Aspergillus niger uncharacterized protein XP_001402240.3 2144561 R 5061 CDS An04g08830 4991287 join(2147021..2147109,2147174..2147240,2147299..2147369,2147424..2147604,2147651..2147845,2147893..2148409,2148473..2148600) VI 1 NT_166539.1 Function: coatomer from ret1-1 cells but not from ret2-1 cells binds to the cytosolic tail of Emp47p.; Function: protein of S. cerevisiae may recycle to ER because it is found in ER is a sec12 mutant.; Function: retrieval of Emp47p from Golgi blocked in ufe1-1, sec20-1, and sec21-1 mutants.; Localization: protein of S. cerevisiae is a Golgi membrane protein.; Similarity: only shows similarity to the aminoterminal part of the S. cerevisiae protein.; Title: similarity to Golgi membrane protein Emp47 -Saccharomyces cerevisiae; uncharacterized protein 2148600 4991287 An04g08830 Aspergillus niger uncharacterized protein XP_001402241.3 2147021 D 5061 CDS An04g08840 4991288 complement(join(2150284..2150692,2150755..2151534,2151591..2152948)) VI 1 NT_166539.1 Phenotype: mutations in the APECED apeced gene are thought to be involved in the autosomal rezessive autoimmune polyglandular syndrome type I.; Remark: the H. sapiens AIRE (autoimmune regulator) is thought to be a transcription factor.; Similarity: the predicted A. niger protein encodes two zinc-finger-like motifs (aa 464-505, 587-645, PF00628) found in nuclear proteins which are involved in chromatin-mediated transcriptional regulation.; Title: similarity to hypothetical autoimmune regulator AIRE-2 - Homo sapiens; See PMID 9398839; uncharacterized protein 2152948 4991288 An04g08840 Aspergillus niger uncharacterized protein XP_001402242.1 2150284 R 5061 CDS An04g08850 84591035 join(2153573..2153621,2153831..2153927,2154021..2154091,2154157..2154238,2154311..2154388,2154508..2154630,2154770..2154831,2154918..2155072) VI 1 NT_166539.1 hypothetical protein 2155072 84591035 An04g08850 Aspergillus niger hypothetical protein XP_059600678.1 2153573 D 5061 CDS An04g08860 4991290 complement(join(2155720..2155910,2155977..2156789,2156863..2156967,2157038..2157121,2157413..2157440)) VI 1 NT_166539.1 Function: the S. pombe 442K curved DNA-binding protein is a non essential protein that preferentially binds curved DNA and binds non-curved DNA with a much lower affinity.; Remark: the S. pombe 442K curved DNA-binding protein was isolated by means of a DNA-binding gel shift assay with synthetic curved DNA.; Similarity: the S. pombe 442K curved DNA-binding protein belongs to the peptidase family M24C, also known as the map family 2.; Title: strong similarity to 442K curved DNA-binding protein SPAC23H4.09 - Schizosaccharomyces pombe; nucleus; See PMID 7985416; uncharacterized protein 2157440 4991290 An04g08860 Aspergillus niger uncharacterized protein XP_001402244.1 2155720 R 5061 CDS An04g08870 84591036 join(2158015..2158032,2158135..2158455) VI 1 NT_166539.1 hypothetical protein 2158455 84591036 An04g08870 Aspergillus niger hypothetical protein XP_059600679.1 2158015 D 5061 CDS An04g08880 4991292 join(2159414..2159596,2159679..2159715,2159789..2159859,2159914..2160296,2160357..2160852) VI 1 NT_166539.1 Remark: Blastp matches are due to repetetive sequences.; Title: similarity to hypothetical protein CAD60573.1 - Podospora anserina; uncharacterized protein 2160852 4991292 An04g08880 Aspergillus niger uncharacterized protein XP_059600680.1 2159414 D 5061 CDS An04g08890 4991293 join(2161506..2161794,2161899..2163075,2163144..2163284,2163363..2163390) VI 1 NT_166539.1 Catalytic activity: the predicted P. eryngii protein converts aromatic primary alcohol and O(2) to an aromatic aldehyde and H(2)O(2).; Remark: the pedicted A. niger protein shows strong similarity to the conserved PFAM domain PF00732, which encodes a glucose-methanol-choline (GMC) oxidoreductase sequence common for a lot of proteins like choline dehydrogenase (CHD), methanol oxidase (MOX) and cellobiose dehydrogenase.; Title: strong similarity to aryl-alcohol oxidase precursor aao - Pleurotus eryngii; See PMID 1425667; uncharacterized protein 2163390 4991293 An04g08890 Aspergillus niger uncharacterized protein XP_001402247.3 2161506 D 5061 CDS An04g08900 4991294 2164140..2165036 VI 1 NT_166539.1 Title: strong similarity to hypothetical protein 68B2.50 - Neurospora crassa; uncharacterized protein 2165036 4991294 An04g08900 Aspergillus niger uncharacterized protein XP_001402248.1 2164140 D 5061 CDS An04g08910 84591037 complement(join(2165224..2165773,2165890..2165993)) VI 1 NT_166539.1 hypothetical protein 2165993 84591037 An04g08910 Aspergillus niger hypothetical protein XP_059600681.1 2165224 R 5061 CDS An04g08920 4991296 join(2166252..2166389,2166552..2168735,2168847..2169182) VI 1 NT_166539.1 Function: the S. cerevisiae SNF5 gene affects expression of both glucose- and phosphate-regulated genes.; Remark: alternative names of the S. cerevisiae SNF5 protein are HAF4, SWI10, TYE4 and the systematic name is YBR289W.; Similarity: the predicted A. niger protein shows similarity to a broad range of transcriptin factors conserved regions.; Title: strong similarity to transcription activator Snf5 - Saccharomyces cerevisiae; nucleus; See PMID 2233708; uncharacterized protein 2169182 4991296 An04g08920 Aspergillus niger uncharacterized protein XP_001402250.3 2166252 D 5061 CDS An04g08930 84591038 complement(join(2169522..2169688,2169743..2169770)) VI 1 NT_166539.1 hypothetical protein 2169770 84591038 An04g08930 Aspergillus niger hypothetical protein XP_059600682.1 2169522 R 5061 CDS An04g08940 4991298 complement(2170541..>2172499) VI 1 NT_166539.1 Phenotype: mutation in the bimD gene of Aspergillus nidulans results in a mitotic block in anaphase characterized by a defective mitosis.; Remark: the ORF is truncated due to the border of the contig.; Title: strong similarity to hypothetical mitosis regulatory protein bimD - Aspergillus nidulans [truncated ORF]; See PMID 8375649; uncharacterized protein 2172499 4991298 An04g08940 Aspergillus niger uncharacterized protein XP_001402252.1 2170541 R 5061 CDS An04g08950 84591039 join(2173009..2173276,2173417..2173495,2173700..2173743,2173985..2174205,2174285..2174311) VI 1 NT_166539.1 Title: questionable ORF; uncharacterized protein 2174311 84591039 An04g08950 Aspergillus niger uncharacterized protein XP_059600683.1 2173009 D 5061 CDS An04g08970 4991301 complement(join(2175729..2176296,2176479..2177310,2177433..2177730)) VI 1 NT_166539.1 Protein sequence is in conflict with the conceptual translation; Function: the function of this domain is not yet known but in analogy with the LIM domain it could be involved in protein-protein interaction and be important for the assembly or activity of multicomponent complexes involved in transcriptional activation or repression.; Similarity: although the function of the predicted protein remains elusive, the expression of this gene is confirmed by the partial identity to A. niger EST EMBLEST:BE759453.; Similarity: besides the similarity to S. pombe SPCC126. 07c, that covers less or more the total length of the predicted protein, the other BLASTP hits are due to a very short, but very conserved, PHD-finger domain.; Similarity: the PHD finger is a C4HC3 zinc-finger-like motif found in nuclear proteins thought to be involved in chromatin-mediated transcriptional regulation; the PHD finger motif is reminiscent of, but distinct from the C3HC4 type RING finger.; Similarity: the predicted protein indeed contains also a RING-type zinc finger.; Title: strong similarity to hypothetical PHD-type zinc finger protein SPCC126.07c - Schizosaccharomyces pombe [putative sequencing error]; putative sequencing error; See PMID 7701562; uncharacterized protein 2177730 4991301 An04g08970 Aspergillus niger uncharacterized protein XP_059600684.1 2175729 R 5061 CDS An04g08980 4991302 complement(join(2178989..2179052,2179183..2179347,2179491..2179521,2179609..2179627)) VI 1 NT_166539.1 Phenotype: S. cerevisiae haploid and diploid null mutants of RPL43A form only microcolonies.; Remark: S. cerevisiae L43A is also called L37A, YL35, RPL43A, YPR043W, YP9499. 02, or YJR094BW.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L43a - Saccharomyces cerevisiae; cytoplasm; See PMID 9396790; See PMID 9421530; See PMID 9559554; 60S ribosomal protein eL43 2179627 4991302 An04g08980 Aspergillus niger 60S ribosomal protein eL43 XP_001402255.1 2178989 R 5061 CDS An04g08990 4991303 join(2180436..2180625,2180686..2180833,2180886..2180958,2181015..2181139,2181197..2181905) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein sll1601 - Synechocystis sp.; uncharacterized protein 2181905 4991303 An04g08990 Aspergillus niger uncharacterized protein XP_001402256.1 2180436 D 5061 CDS An04g09000 4991304 complement(join(2182360..2182637,2182716..2182767,2182847..2183177,2183250..2183359,2183416..2183523,2183619..2183671,2183849..2183927)) VI 1 NT_166539.1 Catalytic activity: epoxide hydrolases catalyze the hydrolysis of an epoxide to a glycol.; Localization: the rat cytosolic epoxide hydrolase is located mainly in the cytoplasm, but also in the peroxisome; this unusual bicompartmental distribution is due to the targeting sequence Ser-Lys-Ile, located at the extreme C-terminus of the rat protein, slightly different from the peroxisomal targeting sequence (PTS) Ser-Lys-Leu found in other peroxisomal enzymes.; Similarity: the C-terminus of the predicted protein is Ser-Arg-Leu; considering that in rat a conservative substitution Leu > Ile causes a difference in the protein targeting, the location of the A. niger putative protein cannot be exactely predicted.; Similarity: the N-terminal half of the predicted protein shows only weak similarity to rat epoxide hydrolase.; Title: strong similarity to epoxide hydrolase -Rattus norvegicus; See PMID 1743286; See PMID 2654139; See PMID 3277731; See PMID 8349641; uncharacterized protein 2183927 4991304 An04g09000 Aspergillus niger uncharacterized protein XP_001402257.1 2182360 R 5061 CDS An04g09010 4991305 2186197..2186523 VI 1 NT_166539.1 Phenotype: null mutation of YPR094w of S. cerevisiae is lethal.; Title: strong similarity to hypothetical protein YPR094w - Saccharomyces cerevisiae; uncharacterized protein 2186523 4991305 An04g09010 Aspergillus niger uncharacterized protein XP_001402258.1 2186197 D 5061 CDS An04g09020 4991306 complement(join(2186589..2186743,2186823..2186931,2186990..2187241,2187335..2187972,2188115..2188133)) VI 1 NT_166539.1 Function: TWF1 of S. cerevisiae acts as an actin monomer sequestering protein in vitro and is involved in regulation of the cortical actin cytoskeleton; no kinase activity was detected for purified yeast twinfilin.; Phenotype: in S. cerevisiae diploid homozygous deletion mutants of TWF1 show random budding pattern and bumpy surface morphology, while TWF1 overexpression causes depolarization of the cortical actin cytoskeleton.; Remark: TWF1 of S. cerevisiae is also called YGR080w.; Similarity: the predicted ORF shows stronger similarity to Human and mouse A6 kinase, a protein whit kinase activity in vitro, but with unknown physiological function; A6 kinases are of special interest because they lack any of the motifs commonly conserved in the catalytic domains of protein kinases.; Title: similarity to twinfilin A Twf1 -Saccharomyces cerevisiae; See PMID 9020587; See PMID 9249064; See PMID 9700161; See PMID 7507208; uncharacterized protein 2188133 4991306 An04g09020 Aspergillus niger uncharacterized protein XP_059600685.1 2186589 R 5061 CDS An04g09030 4991307 complement(join(2188631..2189244,2189312..2189510,2189562..2189611,2189675..2189722,2189778..2189844)) VI 1 NT_166539.1 Function: SFC1 of S. cerevisiae is a mitochondrial succinate-fumarate transporter, involved in the regulation of acetyl-CoA synthetase activity.; Induction: SFC1 of S. cerevisiae is induced by ethanol or acetate as sole carbon sources, whereas is repressed by glucose.; Remark: SFC1 of S. cerevisiae is also called ACR1 or YJR095w.; Title: strong similarity to mitochondrial succinate-fumarate transporter Sfc1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9395087; See PMID 9559855; See PMID 9894915; See PMID 7908717; uncharacterized protein 2189844 4991307 An04g09030 Aspergillus niger uncharacterized protein XP_001402260.1 2188631 R 5061 CDS An04g09040 84591040 join(2189932..2189956,2190064..2190158,2190211..2190269,2190311..2190439,2190573..2190731,2190937..2191093) VI 1 NT_166539.1 hypothetical protein 2191093 84591040 An04g09040 Aspergillus niger hypothetical protein XP_059600686.1 2189932 D 5061 CDS An04g09050 4991309 join(2192528..2193279,2193344..2193875,2193917..2193940) VI 1 NT_166539.1 Similarity: the ORF shows similarity to some probable transmembrane proteins.; Title: strong similarity to hypothetical sterol transporter YMR034c - Saccharomyces cerevisiae; uncharacterized protein 2193940 4991309 An04g09050 Aspergillus niger uncharacterized protein XP_059600687.1 2192528 D 5061 CDS An04g09060 4991310 complement(join(2194089..2194953,2195009..2195460)) VI 1 NT_166539.1 hypothetical protein 2195460 4991310 An04g09060 Aspergillus niger hypothetical protein XP_001402263.1 2194089 R 5061 CDS An04g09062 4991311 join(2196130..2196364,2196419..2196511,2196566..2196792,2196843..2197730) VI 1 NT_166539.1 Function: the X. laevis PARN enzyme is a poly(A)-specific 3' exonuclease that does not require an A residue at the 3' end. The addition of 25 nonadenylate residues at the 3' terminus, or a 3' terminal phosphate is inhibitory.; Title: strong similarity to poly(A)-specific ribonuclease PARN - Xenopus laevis; uncharacterized protein 2197730 4991311 An04g09062 Aspergillus niger uncharacterized protein XP_059600688.1 2196130 D 5061 CDS An04g09065 4991312 join(2198524..2198569,2198628..2199349) VI 1 NT_166539.1 Remark: synonyms for YmL17 from S. cerevisiae are YNL252c, YmL30, rotein N0864.; Title: similarity to ribosomal protein of the large subunit Yml17 - Saccharomyces cerevisiae; See PMID 9151978; mitochondrial 54S ribosomal protein mL46 2199349 4991312 An04g09065 Aspergillus niger mitochondrial 54S ribosomal protein mL46 XP_001402265.3 2198524 D 5061 CDS An04g09070 4991313 2204997..2207768 VI 1 NT_166539.1 Function: ramA of C. stercorarium hydrolysis terminal non-reducing alpha-L-rhamnoase residues in alpha-L-rhamnosides.; Title: strong similarity to alpha-L-rhamnosidase ramA - Clostridium stercorarium; See PMID 10632887; uncharacterized protein 2207768 4991313 An04g09070 Aspergillus niger uncharacterized protein XP_001402266.1 2204997 D 5061 CDS An04g09080 4991314 join(<2212571..2215655,2215725..2216056) VI 1 NT_166539.1 Function: IgA protease of H. influenzae cleaves host immunoglobulinA (an antibody produced by mucosae for defense against pathogens) and thus alleviates host infection.; Remark: the ORF is N-terminally truncated due to it's location at the end of the contig.; Title: similarity to IgA protease IgA1 - Haemophilus influenzae [truncated ORF]; See PMID 11163480; uncharacterized protein 2216056 4991314 An04g09080 Aspergillus niger uncharacterized protein XP_001402267.3 2212571 D 5061 CDS An04g09090 4991315 join(2217787..2217895,2217964..2219439,2219656..2220668) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein AAM08685.1 - Aspergillus fumigatus; uncharacterized protein 2220668 4991315 An04g09090 Aspergillus niger uncharacterized protein XP_059600689.1 2217787 D 5061 CDS An04g09100 4991316 complement(2221138..2223201) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein YLR002c - Saccharomyces cerevisiae; uncharacterized protein 2223201 4991316 An04g09100 Aspergillus niger uncharacterized protein XP_001402269.1 2221138 R 5061 CDS An04g09120 4991317 join(2224796..2224843,2224961..2225004,2225748..2225818,2225869..2226043,2226114..2226552) VI 1 NT_166539.1 Similarity: the ORF shows weak similarity to YLR128W of S. cerevisiae which is believed to be involved in cell polarity.; Title: similarity to hypothetical protein SPBC839.03c - Schizosaccharomyces pombe; uncharacterized protein 2226552 4991317 An04g09120 Aspergillus niger uncharacterized protein XP_001402270.3 2224796 D 5061 CDS An04g09130 4991318 complement(join(2227011..2227037,2227199..2227465,2227524..2227799,2227880..2227984)) VI 1 NT_166539.1 Remark: in our prediction no transmembrane domains were found, whereas the similar protein pmp22 is an integral membrane protein of the peroxisome membrane.; Title: similarity to peroxisomal membrane protein PMP22 - Arabidopsis thaliana; peroxisome; See PMID 10318708; uncharacterized protein 2227984 4991318 An04g09130 Aspergillus niger uncharacterized protein XP_059600690.1 2227011 R 5061 CDS An04g09140 84591041 join(2228881..2228975,2229088..2229222,2229419..2229489,2229564..2231218) VI 1 NT_166539.1 Function: the ORF sequence shows weak similarity to human dynactin-1 (DCTN1), which is involved in retrograde movement of vesicles and organelles along microtubules.; Remark: no tRNA ligase was found in the BLASTp output, although a Prosite tRNA ligase pattern was predicted.; Title: similarity to hypothetical protein AAM08684.1 - Aspergillus fumigatus; uncharacterized protein 2231218 84591041 An04g09140 Aspergillus niger uncharacterized protein XP_059600691.1 2228881 D 5061 CDS An04g09150 4991320 join(2231712..2232016,2232134..2232896) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein AAM08678.1 - Aspergillus fumigatus; uncharacterized protein 2232896 4991320 An04g09150 Aspergillus niger uncharacterized protein XP_001402273.3 2231712 D 5061 CDS An04g09160 4991321 complement(join(2232960..2233028,2233213..2233289,2233331..2233838)) VI 1 NT_166539.1 Remark: unusual intron/exon structure for A. niger.; hypothetical protein 2233838 4991321 An04g09160 Aspergillus niger hypothetical protein XP_059600692.1 2232960 R 5061 CDS An04g09170 4991322 join(2235099..2235148,2235216..2235243,2235312..2235367,2235429..2235678,2235747..2237238,2237289..2237875) VI 1 NT_166539.1 Complex: Cdc48p interacts with Ufd3p, an WD containing protein involved in a proteasome dependend proteolytic pathway distinct from the N-end rule pathway.; Function: S. cerevisiae Cdc48p is an essential ATPase required for the cell cycle progression and the homotypic fusion of endoplasmic reticulum membranes.; Localization: S. cerevisiae Cdc48p is mainly attached to the endoplasmic reticulum, but relocalizes in a cell cycle-dependent manner and enters the nucleus during late G1.; Remark: valosin-containing protein VCP, a highly conserved human homolog of Cdc48p, is a multi-ubiquitin chain-targeting factor required in ubiquitin-proteasome degradation.; Similarity: the A. niger EST an_3570 in EMBLEST:BE759220 overlaps with the ORF.; Title: strong similarity to valosin-containing protein like AAA-ATPase Cdc48 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 1860879; uncharacterized protein 2237875 4991322 An04g09170 Aspergillus niger uncharacterized protein XP_001402275.1 2235099 D 5061 CDS An04g09190 4991323 complement(2238326..2238916) VI 1 NT_166539.1 hypothetical protein 2238916 4991323 An04g09190 Aspergillus niger hypothetical protein XP_001402276.1 2238326 R 5061 CDS An04g09200 84591042 join(2240452..2240511,2240583..2240647,2240769..2240886) VI 1 NT_166539.1 hypothetical protein 2240886 84591042 An04g09200 Aspergillus niger hypothetical protein XP_059600693.1 2240452 D 5061 CDS An04g09210 84591043 complement(join(2242331..2242439,2242565..2242945,2243046..2243282,2243344..2243363)) VI 1 NT_166539.1 hypothetical protein 2243363 84591043 An04g09210 Aspergillus niger hypothetical protein XP_059600694.1 2242331 R 5061 CDS An04g09220 4991326 join(2243369..2243636,2243713..2243874,2243947..2244983) VI 1 NT_166539.1 Complex: S. cerevisiae Ste11p and Ste50p associate through their respective N-terminal domains.; Function: the S. cerevisiae homolog Ste50p is involved in the regulation and direction of Ste11p activity. Ste11p, which is a MAPKKK, is involved in several signaling cascades, like the pheromone response pathway or the high osmolarity glycerol (HOG) pathway.; Title: strong similarity to protein involved in pheromone signal transduction pathway Ste50 - Saccharomyces cerevisiae [putative sequencing error]; putative sequencing error; uncharacterized protein 2244983 4991326 An04g09220 Aspergillus niger uncharacterized protein XP_001402279.1 2243369 D 5061 CDS An04g09230 4991327 complement(2246953..2250147) VI 1 NT_166539.1 Function: the S. cerevisiae homolog Nha1p is an alkalication antiporter mediating Na+ and K+ efflux through the plasma membrane that. Nha1p is required for alkali cation tolerance at acidic pH and enables growth on high concentrations of KCl and NaCl at acidic pH.; Title: strong similarity to Na+/H+-exchanging protein Nha1 - Saccharomyces cerevisiae; plasma membrane; uncharacterized protein 2250147 4991327 An04g09230 Aspergillus niger uncharacterized protein XP_001402280.1 2246953 R 5061 CDS An04g09240 84591044 join(2252781..2252902,2253045..2253103,2253290..2253492,2253759..2253794,2254330..2254339,2254389..2254459,2254516..2254672,2254787..2254798,2254995..2255143) VI 1 NT_166539.1 hypothetical protein 2255143 84591044 An04g09240 Aspergillus niger hypothetical protein XP_059600695.1 2252781 D 5061 CDS An04g09250 4991329 complement(join(2255361..2255570,2255659..2256249,2256314..2256456,2256513..2256708,2256921..2256935,2257302..2257823)) VI 1 NT_166539.1 Function: the S. cerevisiae homolog Mvp1p is required for sorting proteins to the yeast vacuole and inteacts genetically with VPS1.; Similarity: S. cerevisiae Mvp1p shows homology to the family of sorting nexins (SNX).; Title: strong similarity to protein involved in vacuolar protein sorting Mvp1 - Saccharomyces cerevisiae; uncharacterized protein 2257823 4991329 An04g09250 Aspergillus niger uncharacterized protein XP_059600696.1 2255361 R 5061 CDS An04g09260 4991330 complement(join(2259055..2259825,2259988..2261894,2261946..2261997)) VI 1 NT_166539.1 Similarity: belongs to the superfamily of AAA-type ATPases (ATPases associated with various cellular activities).; Title: strong similarity to hypothetical protein SPBC947.11c - Schizosaccharomyces pombe; uncharacterized protein 2261997 4991330 An04g09260 Aspergillus niger uncharacterized protein XP_059600697.1 2259055 R 5061 CDS An04g09270 4991331 join(2262460..2262624,2262693..2265233) VI 1 NT_166539.1 Title: weak similarity to SAP90 associated protein SAPAP1 from patent JP10201477-A - Homo sapiens; uncharacterized protein 2265233 4991331 An04g09270 Aspergillus niger uncharacterized protein XP_001402284.1 2262460 D 5061 CDS An04g09290 84591045 complement(join(2266975..2270429,2270487..2270565)) VI 1 NT_166539.1 Function: the Emericella nidulans homolog amdX is involved in the regulation of the acetamidase-encoding amdS gene.; Title: strong similarity to DNA binding regulatory protein amdX - Aspergillus nidulans; uncharacterized protein 2270565 84591045 An04g09290 Aspergillus niger uncharacterized protein XP_059600698.1 2266975 R 5061 CDS An04g09300 84591046 join(2270853..2270924,2271124..2271214,2271314..2271480,2271567..2271794) VI 1 NT_166539.1 hypothetical protein 2271794 84591046 An04g09300 Aspergillus niger hypothetical protein XP_059600699.1 2270853 D 5061 CDS An04g09310 84591047 join(2271805..2271855,2271928..2272077,2272241..2272519) VI 1 NT_166539.1 hypothetical protein 2272519 84591047 An04g09310 Aspergillus niger hypothetical protein XP_059600700.1 2271805 D 5061 CDS An04g09320 84591048 join(2273078..2273255,2273365..2273397,2273479..2273549) VI 1 NT_166539.1 hypothetical protein 2273549 84591048 An04g09320 Aspergillus niger hypothetical protein XP_059600701.1 2273078 D 5061 CDS An04g09330 84591049 join(2273634..2273771,2273919..2274167,2274266..2274416,2274446..2274714) VI 1 NT_166539.1 hypothetical protein 2274714 84591049 An04g09330 Aspergillus niger hypothetical protein XP_059600702.1 2273634 D 5061 CDS An04g09340 84591050 complement(join(2275454..2275586,2275740..2276113)) VI 1 NT_166539.1 hypothetical protein 2276113 84591050 An04g09340 Aspergillus niger hypothetical protein XP_059600703.1 2275454 R 5061 CDS An04g09350 84591051 join(2277146..2277256,2277354..2277444,2278776..2278922,2280269..2280328,2280559..2280659,2280748..2280831,2280965..2281041,2281264..2281381) VI 1 NT_166539.1 Title: strong similarity to EST SEQ ID NO:4226 from patent WO200056762-A2 - Aspergillus niger; uncharacterized protein 2281381 84591051 An04g09350 Aspergillus niger uncharacterized protein XP_059600704.1 2277146 D 5061 CDS An04g09360 4991339 complement(join(2281449..2281569,2281713..2282428)) VI 1 NT_166539.1 Similarity: the ORF shows strong similarity to expressed sequence tag SEQ ID NO:5624 of patent WO200056762-A2 from Aspergillus oryzae.; Title: strong similarity to hypothetical protein CC0812 - Caulobacter crescentus; uncharacterized protein 2282428 4991339 An04g09360 Aspergillus niger uncharacterized protein XP_001402292.3 2281449 R 5061 CDS An04g09370 84591052 join(2282560..2282845,2282946..2283049) VI 1 NT_166539.1 hypothetical protein 2283049 84591052 An04g09370 Aspergillus niger hypothetical protein XP_059600705.1 2282560 D 5061 CDS An04g09380 4991341 join(2283580..2283935,2283982..2285287) VI 1 NT_166539.1 Function: the A. nidulans homolog prnB encodes the major proline transport system.; Similarity: A. nidulans prnB is highly similar to the arginine and histidine transporters of S. cerevisiae.; Title: strong similarity to proline permease prnB -Aspergillus nidulans; uncharacterized protein 2285287 4991341 An04g09380 Aspergillus niger uncharacterized protein XP_001402294.3 2283580 D 5061 CDS An04g09390 4991342 2285910..2286743 VI 1 NT_166539.1 Catalytic activity: Streptomyces sp. dauC transfers a methyl group from S-adenosylmethionine to aklanonic acid.; Pathway: daunomycin biosynthesis.; Remark: the Streptomyces sp. homolog dauC is a homodimer with an M(r) of ca. 48,000.; Title: similarity to hypothetical aklanonic acid methyltransferase dauC - Streptomyces sp.; uncharacterized protein 2286743 4991342 An04g09390 Aspergillus niger uncharacterized protein XP_001402295.1 2285910 D 5061 CDS An04g09400 4991343 join(2290941..2291827,2291896..2292793,2292877..2293068,2293124..2293456) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein encoded by An01g12020 - Aspergillus niger; uncharacterized protein 2293456 4991343 An04g09400 Aspergillus niger uncharacterized protein XP_001402296.3 2290941 D 5061 CDS An04g09410 4991344 join(2295235..2295512,2295575..2295804,2295864..2295965,2296043..2296236) VI 1 NT_166539.1 Catalytic activity: D-arabinitol + NAD(+) <=> D-xylulose + NADH.; Function: the Bacillus spec. homolog AAY56815 encodes a D-arabinitol dehydrogenase.; Title: strong similarity to D-arabinitol dehydrogenase AAY56815 from patent JP11332569-A - Bacillus sp.; uncharacterized protein 2296236 4991344 An04g09410 Aspergillus niger uncharacterized protein XP_001402297.1 2295235 D 5061 CDS An04g09420 4991345 join(2297615..2297781,2297832..2297845,2297898..2297970,2298017..2298348,2298396..2298754,2298805..2299146,2299199..2299282) VI 1 NT_166539.1 Function: the Neurospora crassa homolog mtr is required for the transport of neutral aliphatic and aromatic amino acids via the N system.; Title: strong similarity to neutral amino acid permease mtr - Neurospora crassa; uncharacterized protein 2299282 4991345 An04g09420 Aspergillus niger uncharacterized protein XP_001402298.1 2297615 D 5061 CDS An04g09430 84591053 join(2299424..2299488,2299558..2299618) VI 1 NT_166539.1 hypothetical protein 2299618 84591053 An04g09430 Aspergillus niger hypothetical protein XP_059600706.1 2299424 D 5061 CDS An04g09440 4991347 complement(join(<2299727..2300393,2300446..2300762)) VI 1 NT_166539.1 Remark: the A. niger ORF is C-terminally truncated due to the contig border.; hypothetical protein [truncated ORF] 2300762 4991347 An04g09440 Aspergillus niger hypothetical protein [truncated ORF] XP_001402300.3 2299727 R 5061 CDS An04g09450 84591054 join(2300868..2301157,2301299..2301504,2301611..2301720) VI 1 NT_166539.1 Remark: blastp matches are unspecific.; hypothetical protein 2301720 84591054 An04g09450 Aspergillus niger hypothetical protein XP_059600707.1 2300868 D 5061 CDS An04g09460 84591055 complement(join(2302014..2302171,2302275..2302427,2302539..2302632)) VI 1 NT_166539.1 hypothetical protein 2302632 84591055 An04g09460 Aspergillus niger hypothetical protein XP_059600708.1 2302014 R 5061 CDS An04g09470 84591056 join(2303512..2303558,2303634..2303725,2303822..2303914,2303953..2304164) VI 1 NT_166539.1 hypothetical protein 2304164 84591056 An04g09470 Aspergillus niger hypothetical protein XP_059600709.1 2303512 D 5061 CDS An04g09480 4991351 join(2304308..2304356,2304405..2304676,2304741..2305478) VI 1 NT_166539.1 Catalytic activity: idhA of S. loti catalyzes the reaction myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH.; Remark: the A. niger ORF shows similarity to different dehydrogenases.; Title: similarity to myo-inositol dehydrogenase idhA - Sinorhizobium meliloti; See PMID 9802033; uncharacterized protein 2305478 4991351 An04g09480 Aspergillus niger uncharacterized protein XP_001402304.3 2304308 D 5061 CDS An04g09490 4991352 join(2306582..2306593,2306667..2306749,2306815..2306972,2307002..2307087,2307191..2307202,2307275..2307339,2307473..2307521,2307603..2307609,2307641..2307699,2307845..2307988,2308232..2308249,2308337..2308467,2308650..2308679,2308752..2309229) VI 1 NT_166539.1 hypothetical protein 2309229 4991352 An04g09490 Aspergillus niger hypothetical protein XP_059600710.1 2306582 D 5061 CDS An04g09500 10098354 2311470..2312120 VI 1 NT_166539.1 Similarity: the a. niger protein also shows similarity to Arabidopsis thaliana protein fragment SEQ ID NO: 52144 from patent EP1033405-A2.; Title: strong similarity to hypothetical aldehyde reductase 6 alr6 - Colletotrichum gloeosporioides; uncharacterized protein 2312120 10098354 An04g09500 Aspergillus niger uncharacterized protein XP_003188671.2 2311470 D 5061 CDS An04g09510 4991354 join(2314761..2315229,2315292..2315348,2315401..2315786) VI 1 NT_166539.1 Title: similarity to hypothetical UbiE/COQ5 family methlytransferase - Caulobacter crescentus; uncharacterized protein 2315786 4991354 An04g09510 Aspergillus niger uncharacterized protein XP_059605275.1 2314761 D 5061 CDS An04g09520 4991355 complement(join(2316140..2316450,2316506..2316957,2317014..2317137,2317194..2317320,2317383..2317610)) VI 1 NT_166539.1 Function: in Aspergillus sp. the biosynthesis of aflatoxins (B(1), G(1), B(2), and G(2)) is a multi-enzyme process controlled genetically by over 20 genes including omtB.; Function: omtB of Aspergillus sp. catalyses the conversion of demethylsterigmatocystin (DMST) to sterigmatocystin (ST) and dihydrodemethylsterigmatocystin (DHDMST) to dihydrosterigmatocystin (DHST).; Remark: aflatoxins are polyketide-derived secondary metabolites.; Title: strong similarity to O-methyltransferase omtB - Aspergillus flavus; See PMID 10328980; See PMID 10806361; uncharacterized protein 2317610 4991355 An04g09520 Aspergillus niger uncharacterized protein XP_001402308.1 2316140 R 5061 CDS An04g09530 4991356 join(2318423..2318463,2319085..2319385,2319448..2322870,2322923..2324149) VI 1 NT_166539.1 Similarity: Nodulisporium sp. pks contains a ketoacyl synthase and an acyl transferase domain.; Title: strong similarity to melanin polyketide synthase PKS - Nodulisporium sp.; See PMID 10628853; uncharacterized protein 2324149 4991356 An04g09530 Aspergillus niger uncharacterized protein XP_001402309.3 2318423 D 5061 CDS An04g09540 4991357 complement(join(2324597..2325012,2325073..2325720,2325780..2325854,2325915..2326038)) VI 1 NT_166539.1 Function: rabbit CYP4A4 hydroxylates fatty acids in the omega-position.; Localization: rabbit CYP4A4 was isolated from microsomes.; Title: similarity to fatty acid omega-hydroxylase cytochrome P-450 CYP4A4 - Oryctolagus cuniculus; See PMID 8239664; uncharacterized protein 2326038 4991357 An04g09540 Aspergillus niger uncharacterized protein XP_001402310.3 2324597 R 5061 CDS An04g09550 4991358 complement(join(2328041..2328179,2328274..2328721,2328776..2329411,2329469..2329787,2329837..2329916,2329973..2330095,2330160..2330241)) VI 1 NT_166539.1 Complex: P. fluorescens hapE forms a homodimer of approximately 140 kDa with each subunit containing a noncovalently bound FAD molecule.; Function: P. fluorescens hapE catalyses Baeyer-Villiger oxidation of aromatic compounds.; Function: P. fluorescens hapE catalyses the NADPH-dependent oxidation of 4-hydroxyacetophenone to 4-hydroxyphenyl acetate and a wide range of other acetophenones are accepted as substrate.; Title: strong similarity to 4-Hydroxyacetophenone monooxygenase hapE - Pseudomonas fluorescens; See PMID 11322873; uncharacterized protein 2330241 4991358 An04g09550 Aspergillus niger uncharacterized protein XP_001402311.3 2328041 R 5061 CDS An04g09560 4991359 complement(join(2330899..2331096,2331158..2331496)) VI 1 NT_166539.1 Remark: information regarding M. anisopliae 4MeS has not yet been published and is available from http://www. fgsc. net/asilomar/pathfact. html.; Title: similarity to hypothetical protein 4MeS -Metarhizium anisopliae; uncharacterized protein 2331496 4991359 An04g09560 Aspergillus niger uncharacterized protein XP_001402312.1 2330899 R 5061 CDS An04g09570 4991360 join(2334048..2334301,2334356..2335691) VI 1 NT_166539.1 Function: S. cerevisiae TPO1 is a H(+)-gradient dependent vacuolar import polyamine transporter specific for spermidine and spermine.; Remark: the systematic name for S. cerevisiae TPO1 is YLL028W.; Title: strong similarity to polyamine transport protein Tpo1 - Saccharomyces cerevisiae; vacuole; See PMID 9920864; See PMID 10585849; See PMID 11171066; uncharacterized protein 2335691 4991360 An04g09570 Aspergillus niger uncharacterized protein XP_001402313.1 2334048 D 5061 CDS An04g09580 4991361 complement(join(2336541..2337427,2337475..2337840,2337944..2338243,2338736..2339582)) VI 1 NT_166539.1 Function: E. faecalis kanamycin kinas confers kanamycin resistance.; Similarity: E. faecalis kanamycin kinase is a 3'5''-aminoglycoside phosphotransferase of type III.; Title: weak similarity to kanamycin kinase -Enterococcus faecalis; See PMID 6313476; uncharacterized protein 2339582 4991361 An04g09580 Aspergillus niger uncharacterized protein XP_059605276.1 2336541 R 5061 CDS An04g09590 84591057 join(2340180..2340303,2340493..2340917) VI 1 NT_166539.1 hypothetical protein 2340917 84591057 An04g09590 Aspergillus niger hypothetical protein XP_059605277.1 2340180 D 5061 CDS An04g09600 4991363 complement(join(2341479..2342080,2342167..2342269,2342424..2342543,2342590..2343305,2343359..2343437)) VI 1 NT_166539.1 hypothetical protein 2343437 4991363 An04g09600 Aspergillus niger hypothetical protein XP_059605278.1 2341479 R 5061 CDS An04g09610 4991364 2344296..2345789 VI 1 NT_166539.1 Function: S. cerevisiae SNG1 acts neiter via depletion of glutathione pools nor DNA repair and its expression is not contolled by MNNG metabolism genes regulator YAP1.; Function: overexpression of S. cerevisiae SNG1 confers hyper-resistance to the mutagen N-methyl-N'nitro-N-nitrosoguanidine (MNNG) while sng1 null mutants exhibit only slight sensitivity to MNNG.; Title: similarity to nitrosoguanidine resistance factor Sng1 - Saccharomyces cerevisiae; See PMID 7753113; uncharacterized protein 2345789 4991364 An04g09610 Aspergillus niger uncharacterized protein XP_001402317.1 2344296 D 5061 CDS An04g09620 4991365 complement(join(2345911..2346619,2346683..2346892,2346949..2347031,2347097..2347259,2347314..2347419,2347468..2347578,2347632..2347739,2347808..2347973)) VI 1 NT_166539.1 Function: S. cerevisiae Agp2p functions as a carnitine-H+ symporter.; Function: carnitine is the carrier for the transport of acetyl-CoA from peroxisomes to mitochondria during beta-oxidation of fatty acids.; Localization: by immunoelectron microscopy S. cerevisiae HA-tagged Agp2 localizes to plasma membrane, ER membranes and vacuoles.; Localization: by western blots of S. cerevisiae HA-tagged Agp2 from fractionated cells and colocalisation with marker enzymes for various subcellular compartments it was shown that Agp2 localizes in the plasma membrane and the ER.; Remark: carnitine is a quatery amine ((R)-3-carboxy-2-hydroxy-N,N,N-tri-methyl-1-propanaminium hydroxide) which has been suggested as a supplement during ketogenic diet.; Remark: the systematic name for S. cerevisiae AGP2 is YBR132c.; Similarity: S. cerevisiae Agp2 belongs to the aa-permease superfamily.; Title: strong similarity to carnitine transporter Agp2 - Saccharomyces cerevisiae; See PMID 10545096; uncharacterized protein 2347973 4991365 An04g09620 Aspergillus niger uncharacterized protein XP_001402318.1 2345911 R 5061 CDS An04g09630 4991366 complement(join(2348476..2348617,2348717..2348877,2348929..2349768)) VI 1 NT_166539.1 Title: similarity to nucleic acid-binding protein NuABP-39 from patent WO200044900-A2 - Homo sapiens; uncharacterized protein 2349768 4991366 An04g09630 Aspergillus niger uncharacterized protein XP_001402319.3 2348476 R 5061 CDS An04g09640 4991367 complement(join(2350783..2351168,2351224..2352097)) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein encoded by An15g02090 - Aspergillus niger; uncharacterized protein 2352097 4991367 An04g09640 Aspergillus niger uncharacterized protein XP_001402320.1 2350783 R 5061 CDS An04g09650 4991368 complement(2352602..2353744) VI 1 NT_166539.1 Function: B. circulans aman6 is a yeast mannan backbone degrading enzyme.; Title: similarity to alpha-1,6-mannanase aman6 -Bacillus circulans; See PMID 11055417; uncharacterized protein 2353744 4991368 An04g09650 Aspergillus niger uncharacterized protein XP_001402321.1 2352602 R 5061 CDS An04g09660 4991369 join(2354815..2354898,2355155..2356210,2356264..2356645,2356716..2357101,2357237..2357254,2357313..2357503,2357593..2357596) VI 1 NT_166539.1 Similarity: similarity with other proteins is due to glutamic acid rich regions.; Title: similarity to hypothetical serine/threonine protein kinase AAO52136.1 - Dictyostelium discoideum; uncharacterized protein 2357596 4991369 An04g09660 Aspergillus niger uncharacterized protein XP_059605279.1 2354815 D 5061 CDS An04g09670 4991370 complement(join(2357833..2358346,2358431..2358892,2358963..2359258)) VI 1 NT_166539.1 Function: Rhodococcus sp. SoxC catalyses the first step of a pathway to remove covalently bound sulfur from dibenzothiophene (dbt) without breaking carbon-carbon bonds.; Function: Rhodococcus sp. SoxC sulfur dioxygenase oxidizes DBT to DBT-5,5'-dioxide.; Remark: an alternative name for Rhodococcus sp. SoxC is dszC.; Similarity: Rhodococcus sp. SoxC is similar to members of the acyl coenzyme A dehydrogenase family.; Title: strong similarity to sulfur dioxygenase SoxC - Rhodococcus sp.; See PMID 7574582; See PMID 7961424; uncharacterized protein 2359258 4991370 An04g09670 Aspergillus niger uncharacterized protein XP_059605280.1 2357833 R 5061 CDS An04g09680 4991371 complement(join(2359698..2360113,2360186..2360381,2360441..2360557)) VI 1 NT_166539.1 Function: mutations in Y. lipolytica GPR1 confer high sensitivity to low concentrations of acetic acid and ethanol, even in presence of glucose.; Function: mutations in Y. lipolytica GPR1 inhibit expression of acetyl-coenzyme A synthetase (ACS), which produces Acetyl-coenzyme A from acetate and therby induces the expression of the glyoxylate cycle enzymes on acetate as carbon source.; Title: similarity to glyxoxylate pathway regulator GPR1 - Yarrowia lipolytica; See PMID 10572261; See PMID 1349449; uncharacterized protein 2360557 4991371 An04g09680 Aspergillus niger uncharacterized protein XP_001402324.1 2359698 R 5061 CDS An04g09690 4991372 complement(join(2360945..2361372,2361423..2361535,2361592..2362034)) VI 1 NT_166539.1 Catalytic activity: pectin methylesterases convert pectin + N H(2)O to N methanol + pectate.; Function: A. aculeatus PME1 acts in synergy with polygalacturonases in the degradation of plant cell wall pectin.; Function: A. aculeatus PME1 is involved in maceration and soft-rotting of plant tissue.; Title: strong similarity to pectin methylesterase pme1 - Aspergillus aculeatus; See PMID 8920970; uncharacterized protein 2362034 4991372 An04g09690 Aspergillus niger uncharacterized protein XP_001402325.1 2360945 R 5061 CDS An04g09700 4991373 join(2362985..2363397,2363461..2364268) VI 1 NT_166539.1 Function: A. tubingensis xghA is involved in carbohydrate utilisation and specifically degrades a xylose-substituted galacturonic acid backbone.; Title: strong similarity to endo-xylogalacturonan hydrolase xghA - Aspergillus tubingensis; See PMID 10618200; uncharacterized protein 2364268 4991373 An04g09700 Aspergillus niger uncharacterized protein XP_001402326.1 2362985 D 5061 CDS An04g09710 10098346 join(2365043..2365261,2365328..2365412,2365472..2365786,2365837..2365952,2366014..2366373) VI 1 NT_166539.1 Catalytic activity: Acetylcholinesterases convert an acetic ester + H(2)O to ester + acetate.; Function: R. norvegicus AChE deacetylates a variety of acetic esters.; Similarity: the predicted A. niger protein shows similarity to several carboxylesterases and lipases.; Title: similarity to acetylcholinesterase AChE -Rattus norvegicus; See PMID 8417155; See PMID 11283752; uncharacterized protein 2366373 10098346 An04g09710 Aspergillus niger uncharacterized protein XP_059605281.1 2365043 D 5061 CDS An04g09720 4991375 complement(join(2367088..2367587,2367673..2367862)) VI 1 NT_166539.1 Title: strong similarity to pathogenicity gene PEP2 - Nectria haematococca; See PMID 11208022; uncharacterized protein 2367862 4991375 An04g09720 Aspergillus niger uncharacterized protein XP_001402328.1 2367088 R 5061 CDS An04g09730 4991376 complement(join(2369428..2369544,2369619..2369772,2369820..2369923,2369991..2370279,2370336..2371438)) VI 1 NT_166539.1 Function: P. vivianii luciferase is an oxidoreductase with characteristics of a ligase, and synthesizes a variety of (di)nucleoside polyphosphates with four or more inner phosphates.; Title: strong similarity to luciferase PvGR -Phrixothrix vivianii; See PMID 10387072; See PMID 11007993; uncharacterized protein 2371438 4991376 An04g09730 Aspergillus niger uncharacterized protein XP_001402329.1 2369428 R 5061 CDS An04g09740 4991377 complement(join(2372456..2373694,2373755..2374063)) VI 1 NT_166539.1 Function: S. cerevisiae QDR1 is a multidrug resistance determinant against ketoconazole and quinidine,but not the stereoisomer quinine.; Localization: in S. cerevisiae fluorescence microscopy observation indicated that Qdr1p is a plasma membrane protein.; Remark: the predicted A. niger protein shows similarity to several S. cerevisiae members of the major facilitator superfamily with different substrate specifities (e. g. BZR1 - low-chain organic acids, DTR1 -dityrosine transporter).; Remark: the systematic name for S. cerevisiae QDR1 is YIL120w.; Similarity: S. cerevisiae QDR1 is a member of the major facilitator superfamily.; Title: similarity to multidrug resistance protein Qdr1 - Saccharomyces cerevisiae; See PMID 11302822; uncharacterized protein 2374063 4991377 An04g09740 Aspergillus niger uncharacterized protein XP_001402330.1 2372456 R 5061 CDS An04g09750 4991378 join(2374928..2375035,2375084..2375209,2375263..2375370,2375443..2376717) VI 1 NT_166539.1 Catalytic activity: folylpolyglutamate synthetases convert ATP + {tetrahydrofolyl-[Glu]}(N) + L-glutamate to ADP + phosphate + {tetrahydrofolyl-[Glu]}(N+1).; Function: S. cerevisiae Met7 is involved in one-carbon metabolism, which is essential to provide activated one-carbon units in the biosynthesis of methionine, purines, and thymidylate.; Function: S. cerevisiae strains without functional met7 are methionine, adenine and thymidine auxotroph and maintenance of mitochondrial DNA is disturbed.; Localization: S. cerevisiae Met7 appears to encode both the cytoplasmic and mitochondrial forms of the enzyme.; Remark: alternative names for S. cerevisiae Met7 are Met23 and YOR241w.; Title: strong similarity to tetrahydrofolylpolyglutamate synthase Met7 - Saccharomyces cerevisiae; See PMID 10775416; See PMID 10799479; uncharacterized protein 2376717 4991378 An04g09750 Aspergillus niger uncharacterized protein XP_001402331.1 2374928 D 5061 CDS An04g09760 4991379 complement(join(2377086..2377740,2377809..2378144,2378216..2378395,2378479..2378642,2378723..>2379256)) VI 1 NT_166539.1 Complex: in N. crassa a direct protein-protein interaction between nit-2 and nit-4 is essential for optimal expression of the nit-3 structural gene.; Function: N. crassa nit-4 is a regulatory gene in the nitrogen circuit and is required for the expression of nit-3 and nit-6.; Remark: ORF 5'truncated due to end of contig.; Similarity: N. crassa nit-4 contains a single Gal4-type Zn(II)2Cys6 binuclear-type zinc finger DNA-binding domain.; Title: similarity to nitrogen assimilation regulatory protein nit-4 - Neurospora crassa [truncated ORF]; nucleus; See PMID 9632783; See PMID 1840634; uncharacterized protein 2379256 4991379 An04g09760 Aspergillus niger uncharacterized protein XP_001402332.3 2377086 R 5061 CDS An04g09770 4991380 2380635..2381600 VI 1 NT_166539.1 Remark: Archaeoglobus fulgidus esterase VC16-16MC encodes a heat stable esterase which is active in organic solvents, useful in cheese or paper manufacture, and to study plant resistance to disease; Remark: Archaeoglobus fulgidus esterase VC16-16MC patent WO9730160-A1.; Title: strong similarity to esterase VC16-16MC from patent WO9730160-A1 - Archaeoglobus fulgidus; uncharacterized protein 2381600 4991380 An04g09770 Aspergillus niger uncharacterized protein XP_001402333.3 2380635 D 5061 CDS An04g09780 84591058 complement(2381897..2382127) VI 1 NT_166539.1 hypothetical protein 2382127 84591058 An04g09780 Aspergillus niger hypothetical protein XP_059600711.1 2381897 R 5061 CDS An04g09790 4991382 complement(join(2382951..2383469,2383527..2384440,2384519..2384597)) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein encoded by An04g07190 - Aspergillus niger; uncharacterized protein 2384597 4991382 An04g09790 Aspergillus niger uncharacterized protein XP_001402335.3 2382951 R 5061 CDS An04g09800 84591059 complement(join(2385729..2385990,2386092..2386148,2386200..2386324)) VI 1 NT_166539.1 hypothetical protein 2386324 84591059 An04g09800 Aspergillus niger hypothetical protein XP_059600712.1 2385729 R 5061 CDS An04g09810 4991384 complement(join(2386560..2387007,2387090..2387910)) VI 1 NT_166539.1 Remark: strong similarity to sugarbeet choline monooxygenase CMO patent WO9830702-A2.; Remark: used to, e. g. transform plants to provide increased resistance to stressful conditions, increase pest resistance or increase feed value.; Title: strong similarity to choline monooxygenase CMO from patent WO9830702-A2 - Beta vulgaris; uncharacterized protein 2387910 4991384 An04g09810 Aspergillus niger uncharacterized protein XP_001402337.1 2386560 R 5061 CDS An04g09820 4991385 join(2388913..2390015,2390072..2390333) VI 1 NT_166539.1 Remark: Fructosyl amino acid oxidase (FAOD), is an active toward model compounds of the glycated proteins in blood, N epsilon-fructosyl N sigma-Z-lysine and N-fructosyl valine.; Title: strong similarity to fructosyl amino acid oxidase faoA - Aspergillus terreus; See PMID 9022674; See PMID 9139700; See PMID 9013588; uncharacterized protein 2390333 4991385 An04g09820 Aspergillus niger uncharacterized protein XP_001402338.1 2388913 D 5061 CDS An04g09830 4991386 complement(join(2390630..2390862,2390918..2391305)) VI 1 NT_166539.1 Function: pat genes encode a phosphinothricin acetyltransferase (PAT) and is widely applied in plant genetic engineering.; Similarity: the similarity of the ORF to pat of S. coelicolor is restricted to the second half of the proteins.; Title: similarity to phosphinothricin acetyltransferase pat - Streptomyces coelicolor; See PMID 9631092; uncharacterized protein 2391305 4991386 An04g09830 Aspergillus niger uncharacterized protein XP_001402339.1 2390630 R 5061 CDS An04g09840 84591060 join(2391797..2391869,2392002..2393164,2393405..2393452) VI 1 NT_166539.1 Title: similarity to hypothetical protein encoded by An16g06250 - Aspergillus niger; uncharacterized protein 2393452 84591060 An04g09840 Aspergillus niger uncharacterized protein XP_059600713.1 2391797 D 5061 CDS An04g09850 4991388 complement(join(2394385..2394492,2394555..2394825,2394882..2395192,2395251..2395269,2395326..2395924,2395964..2396164)) VI 1 NT_166539.1 Remark: Git1p in yeast contains a sugar transport motif and 12 potential membrane-spanning domains. Transport assays performed on a git1 mutant together with the above evidence indicate that the GIT1 gene encodes a permease involved in the uptake of glycerophosphoinositol.; Title: strong similarity to glycerophosphoinositol transporter Git1 - Saccharomyces cerevisiae; See PMID 9691030; uncharacterized protein 2396164 4991388 An04g09850 Aspergillus niger uncharacterized protein XP_059600714.1 2394385 R 5061 CDS An04g09860 84591061 complement(join(2396315..2396452,2396531..2396570,2396781..2397101,2397133..2397345,2397446..2397477)) VI 1 NT_166539.1 hypothetical protein 2397477 84591061 An04g09860 Aspergillus niger hypothetical protein XP_059600715.1 2396315 R 5061 CDS An04g09870 4991390 complement(join(2397673..2397699,2397807..2398632,2398690..2399127,2399203..2399381)) VI 1 NT_166539.1 Catalytic activity: cholesterol + NADPH + O2 = 7alpha-hydroxycholesterol + NADP+ + H2O.; Pathway: bile acid biosynthesis.; Remark: the microsomal oxysterol 7alpha-hydroxylase enzyme, active in the acidic pathway for bile acid synthesis.; Similarity: belongs to the human cytochrome P450 family.; Title: strong similarity to oxysterol 7alpha-hydroxylase CYP7b1 - Homo sapiens; See PMID 9802883; uncharacterized protein 2399381 4991390 An04g09870 Aspergillus niger uncharacterized protein XP_001402343.3 2397673 R 5061 CDS An04g09880 84591062 join(2400703..2400749,2400838..2400918,2401075..2401221,2401398..2401830,2402119..2402181,2402293..2402425,2402582..2402842,2402961..2403090,2403179..2403250,2403340..2403480,2403626..2403770) VI 1 NT_166539.1 hypothetical protein 2403770 84591062 An04g09880 Aspergillus niger hypothetical protein XP_059600716.1 2400703 D 5061 CDS An04g09890 4991392 join(2404185..2404547,2404611..2404786,2404843..2411448,2411504..2411552) VI 1 NT_166539.1 Remark: cell wall protects fungi against lysis and determines their cell shape. Alpha-glucan is a major carbohydrate component of the fungal cell wall; ags1(+),which encodes a putative alpha-glucan synthase consists of two probable catalytic domains for alpha-glucan assembly,namely an intracellular domain for alpha-glucan synthesis and an extracellular domain speculated to cross-link or remodel alpha-glucan.; Title: strong similarity to hypothetical cell wall alpha-glucan synthase ags1p - Schizosaccharomyces pombe; See PMID 9689051; uncharacterized protein 2411552 4991392 An04g09890 Aspergillus niger uncharacterized protein XP_001402345.1 2404185 D 5061 CDS An04g09900 4991393 join(2412307..2412370,2412476..2414076) VI 1 NT_166539.1 Title: strong similarity to hypothetical protein encoded by An07g06270 - Aspergillus niger; uncharacterized protein 2414076 4991393 An04g09900 Aspergillus niger uncharacterized protein XP_001402346.3 2412307 D 5061 CDS An04g09910 4991394 complement(join(2414484..2414696,2414791..2415363,2415433..2415762)) VI 1 NT_166539.1 Remark: LovC Aspergillus terreus interacts with lovastatin nonaketide synthase (LNKS) and is necessary for the correct processing of the growing polyketide chain and production of dihydromonacolin L.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994; uncharacterized protein 2415762 4991394 An04g09910 Aspergillus niger uncharacterized protein XP_001402347.1 2414484 R 5061 CDS An04g09920 4991395 join(2416458..2416599,2416674..2417689) VI 1 NT_166539.1 Remark: similarity to human PRO1072 protein sequence patent WO9946281-A2.; Remark: the ORF seems to be a putative ketoreductase with unknown specificity.; Similarity: belongs to the dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases).; Title: similarity to human PRO1072 protein sequence from patent WO9946281-A2 - Homo sapiens; uncharacterized protein 2417689 4991395 An04g09920 Aspergillus niger uncharacterized protein XP_001402348.3 2416458 D 5061 CDS An04g09930 84591063 complement(join(2418678..2418808,2418851..2418882,2418977..2419089,2419184..2419288,2419417..2419530,2419631..2419765,2419835..2419935,2420066..2420087)) VI 1 NT_166539.1 hypothetical protein 2420087 84591063 An04g09930 Aspergillus niger hypothetical protein XP_059600717.1 2418678 R 5061 CDS An04g09940 4991397 2420292..2420966 VI 1 NT_166539.1 Remark: CIH1 Colletotrichum lindemuthianum is a fungal proline-rich glycoprotein which appears to form a cross-linked structure in planta and, as such, resembles plant cell wall proline- and hydroxyproline-rich proteins.; Title: similarity to intracellular hyphae protein 1 CIH1 - Colletotrichum lindemuthianum; See PMID 9721685; uncharacterized protein 2420966 4991397 An04g09940 Aspergillus niger uncharacterized protein XP_001402350.1 2420292 D 5061 CDS An04g09950 84591064 join(2421208..2421396,2421562..2421676,2421758..2421902,2421980..2422110,2422220..2422308) VI 1 NT_166539.1 hypothetical protein 2422308 84591064 An04g09950 Aspergillus niger hypothetical protein XP_059600718.1 2421208 D 5061 CDS An04g09960 10098356 join(2422487..2422527,2422616..2423411,2423482..2424594) VI 1 NT_166539.1 Catalytic activity: cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide.; Remark: can be used for modification of host cells for the production of heterologous proteins or for producing proteins for use in cleaning compositions.; Remark: similarity to Bacillus subtilis serine protease SP1 (YUXL) patent WO9903984-A2.; Similarity: to dipeptidyl aminopeptidases/acylaminoacyl-peptidases and to colicin tolerance protein tolB from several bacteria. .; Title: similarity to serine protease SP1 YUXL from patent WO9903984-A2 - Bacillus subtilis; uncharacterized protein 2424594 10098356 An04g09960 Aspergillus niger uncharacterized protein XP_059600719.1 2422487 D 5061 CDS An04g09970 84591065 complement(join(2424750..2424857,2424950..2425150)) VI 1 NT_166539.1 hypothetical protein 2425150 84591065 An04g09970 Aspergillus niger hypothetical protein XP_059600720.1 2424750 R 5061 CDS An04g09980 84591066 join(2425275..2425426,2425505..2425892) VI 1 NT_166539.1 Title: similarity to putative nitrilase CAE27004.1 -Rhodopseudomonas palustris; uncharacterized protein 2425892 84591066 An04g09980 Aspergillus niger uncharacterized protein XP_059600721.1 2425275 D 5061 CDS An04g09990 4991402 complement(join(2426122..2426922,2427014..2427058)) VI 1 NT_166539.1 Function: degradation of 2,5-dichloro-2,5-cyclohexadiene-1,4-diol (2,5-ddol) into 2,5-dichlorohydroquinone (2,5-dchq).; Pathway: degradation of gamma-hexachlorocyclohexane.; Remark: also strong similarity to EST an_3163 Aspergillus niger.; Remark: the linC gene Sphingomonas paucimobilis is essential for the assimilation of gamma-HCH in UT26.; Similarity: belongs to the short-chain dehydrogenases/reductases family (sdr).; Title: strong similarity to 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase linC - Sphingomonas paucimobilis; See PMID 7515041; uncharacterized protein 2427058 4991402 An04g09990 Aspergillus niger uncharacterized protein XP_001402355.1 2426122 R 5061 CDS An04g10000 4991403 complement(join(2427631..2428366,2428587..2428952,2429011..2429268,2429323..2429411)) VI 1 NT_166539.1 Similarity: strong similarity to patent WO0100804-A/247 from Corynebacterium glutamicum found in TREMBL:AX066343_1.; Similarity: the ORF shows similarity to several MFS efflux transporters.; Title: strong similarity to multidrug transporter from patent WO0100804-A - Corynebacterium glutamicum; uncharacterized protein 2429411 4991403 An04g10000 Aspergillus niger uncharacterized protein XP_059600722.1 2427631 R 5061 CDS An04g10010 4991404 join(2430093..2430102,2430173..2430192,2430250..2430354,2430436..2430847,2430893..2431371) VI 1 NT_166539.1 Function: M. grisea Pth11 is a pathogenicity gene.; Function: M. grisea Pth11p likely is involved in host surface recognition.; Function: M. grisea pth11 mutants of strain 4091-5-8 are nonpathogenic due to a defect in appressorium differentiation.; Localization: in M. grisea, a Pth11-green fluorescent protein fusion localised to the cell membrane and vacuoles.; Similarity: similarity to the M. grisea Pth11 is limited to the N-terminal half of the protein sequences.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529; uncharacterized protein 2431371 4991404 An04g10010 Aspergillus niger uncharacterized protein XP_059600723.1 2430093 D 5061 CDS An04g10020 4991405 complement(join(2432224..2432792,2432931..2433065,2433101..2433131,2433187..2433228)) VI 1 NT_166539.1 Remark: only the N-terminal domain of the ORF is matching to the central part of the dihydrofolate reductase.; Title: weak similarity to dihydrofolate reductase dfr1p - Schizosaccharomyces pombe; See PMID 8088538; uncharacterized protein 2433228 4991405 An04g10020 Aspergillus niger uncharacterized protein XP_059600724.1 2432224 R 5061 CDS An04g10030 4991406 join(2433907..2434065,2434134..2434278,2434347..2434970,2435060..2435150,2435203..2435537,2435631..2436056,2436153..2439121,2439186..2439247,2439305..2441138,2441200..2442399) VI 1 NT_166539.1 Remark: the multifunctional polyketide synthase (PKS)-encoding gene (PKS1) Cochliobolus heterostrophus has six catalytic domains arranged in the following order,starting at the N terminus: beta-ketoacyl synthase,acyltransferase, dehydratase, enoyl reductase,beta-ketoacyl reductase, and acyl carrier protein.; Remark: the polyketide synthase is required for fungal virulence and production of the polyketide T-toxin.; Title: strong similarity to polyketide synthase PKS1 - Cochliobolus heterostrophus; See PMID 10913297; See PMID 8953776; uncharacterized protein 2442399 4991406 An04g10030 Aspergillus niger uncharacterized protein XP_059600725.1 2433907 D 5061 CDS An04g10040 4991407 join(2443173..2443457,2443514..2443625,2443688..2443789,2443848..2443909,2443970..2444506) VI 1 NT_166539.1 Catalytic activity: the Bacillus subtilis myo-inositol 2-dehydrogenase converts Myo-inositol and NAD(+) to 2,4,6/3,5-pentahydroxycyclohexanone and NADH.; Induction: the Bacillus subtilis myo-inositol 2-dehydrogenase is induced by myo-inositol and is strongly repressed by rapidly metabolizable carbohydrates such as D-glucose, D-mannose, D-fructose and glycerol .; Title: strong similarity to myo-inositol 2-dehydrogenase yisS - Bacillus subtilis; See PMID 6322857; uncharacterized protein 2444506 4991407 An04g10040 Aspergillus niger uncharacterized protein XP_001402360.1 2443173 D 5061 CDS An04g10050 4991408 complement(join(2445115..2445177,2445234..2445641,2445810..2445902,2445955..2446095,2446143..2446284,2446340..2446408,2446475..2446588,2446620..2446759,2446811..2446927,2447004..2447262,2447311..2447546,2447599..2448094,2448156..2448231,2448288..2448323,2448399..2448540)) VI 1 NT_166539.1 Title: similarity to hypothetical transcription regulator protein CAA91958.1 - Schizosaccharomyces pombe; uncharacterized protein 2448540 4991408 An04g10050 Aspergillus niger uncharacterized protein XP_059600726.1 2445115 R 5061 CDS An04g10060 4991409 join(2448866..2449160,2449280..2449628,2449688..2450912) VI 1 NT_166539.1 Remark: the flavin-containing monooxygenases (FMOs) constitute a family of xenobiotic-metabolising enzymes.; Remark: the predicted A. niger protein contains a PF00743 flavin-binding monooxygenase-like domain.; Remark: the predicted A. niger protein shows similarity to a broad range of predicted proteins only C-terminal of aa 190.; Title: similarity to flavin monooxygenase fccC from patent WO200004158-A2 - Bacterium 2412.1; uncharacterized protein 2450912 4991409 An04g10060 Aspergillus niger uncharacterized protein XP_059600727.1 2448866 D 5061 CDS An04g10070 4991410 complement(join(2451581..2451870,2451945..2452272,2452397..2452554,2452619..2452626,2452681..2452765,2452827..2452887)) VI 1 NT_166539.1 Catalytic activity: the uronat dehydrogenase generally converts D-Galacturonate and NAD and H2O to D-Galactarate and NADH.; Remark: the DE19604798-A1 variant can be used for synthesis of L-ascorbic acid.; Title: strong similarity to uronate dehydrogenase variant R57E from patent DE19604798-A1 - Saccharomyces cerevisiae; uncharacterized protein 2452887 4991410 An04g10070 Aspergillus niger uncharacterized protein XP_059600728.1 2451581 R 5061 CDS An04g10080 4991411 complement(join(2453816..2454342,2454405..2454723,2454781..2454821,2454885..2455158)) VI 1 NT_166539.1 Remark: the L. lactis alcohol-acetaldehyde dehydrogenase belongs to the not further caracterised familiy of multifunctional alcohol dehydrogenases.; Title: strong similarity to hypothetical alcohol-acetaldehyde dehydrogenase adhE - Lactococcus lactis; See PMID 9620952; uncharacterized protein 2455158 4991411 An04g10080 Aspergillus niger uncharacterized protein XP_001402364.3 2453816 R 5061 CDS An04g10090 4991412 join(2456370..2456497,2456543..2456843,2456903..2458039) VI 1 NT_166539.1 Pathway: the K. lactis protein RAG5 is involved in the regulation of HGT1.; Remark: the K. lactis HGT1 shows 26 to 31% amino acid identity to the Hxtp family of glucose transport elements in S. cerevisiae.; Title: strong similarity to high-affinity glucose transporter HGT1 - Kluyveromyces lactis; See PMID 8830679; uncharacterized protein 2458039 4991412 An04g10090 Aspergillus niger uncharacterized protein XP_059600729.1 2456370 D 5061 CDS An04g10100 84591067 complement(join(2459637..2459942,2460114..2460578,2460611..2460759,2460842..2460899)) VI 1 NT_166539.1 Title: similarity to polyketide synthase PKS17 -Botryotinia fuckeliana; See PMID 14676319; uncharacterized protein 2460899 84591067 An04g10100 Aspergillus niger uncharacterized protein XP_059600730.1 2459637 R 5061 CDS An04g10110 4991414 join(2462637..2462871,2463097..2463185,2463392..2463436) VI 1 NT_166539.1 Title: similarity to hypothetical protein encoded by An11g00040 - Aspergillus niger; uncharacterized protein 2463436 4991414 An04g10110 Aspergillus niger uncharacterized protein XP_059600731.1 2462637 D 5061 CDS An04g10120 84591068 complement(join(2464382..2464750,2464835..2464848,2465149..2465198,2465228..2465246,2465342..2465510,2465693..2465713)) VI 1 NT_166539.1 Title: weak similarity to hypothetical protein encoded by An16g05030 - Aspergillus niger; uncharacterized protein 2465713 84591068 An04g10120 Aspergillus niger uncharacterized protein XP_059600732.1 2464382 R 5061 CDS An04g10130 4991416 complement(join(2465772..2465988,2466037..2466457,2466523..2467000)) VI 1 NT_166539.1 Catalytic activity: the 3-isopropylmalate dehydrogenase converts 3-carboxy-2-hydroxy-4-methylpentanoate and NAD(+) to 3-carboxy-4-methyl-2-oxopentanoate and NADH.; Gene-ID: leu2B; Pathway: the 3-isopropylmalate dehydrogenase is part of theValine, leucine and isoleucine biosynthesis .; Remark: an alternate name of the 3-isopropylmalate dehydrogenase is beta-isopropylmalate dehydrogenase.; See PMID 8781173; 3-isopropylmalate dehydrogenase leu2B-Aspergillus niger 2467000 leu2B 4991416 leu2B Aspergillus niger 3-isopropylmalate dehydrogenase leu2B-Aspergillus niger XP_001402369.1 2465772 R 5061 CDS An04g10140 4991417 join(2468372..2468598,2468670..2469269,2469371..2470204,2470266..2470389) VI 1 NT_166539.1 hypothetical protein 2470389 4991417 An04g10140 Aspergillus niger hypothetical protein XP_001402370.1 2468372 D 5061 CDS An04g10150 84591069 join(2471419..2471967,2471998..2472006) VI 1 NT_166539.1 Title: similarity to hypothetical protein encoded by An02g12900 - Aspergillus niger; uncharacterized protein 2472006 84591069 An04g10150 Aspergillus niger uncharacterized protein XP_059600733.1 2471419 D 5061 CDS An04g10180 84591070 join(2478203..2478295,2478336..2478441,2478605..2478657) VI 1 NT_166539.1 Catalytic activity: C. symbiosum hgdB catalyses the elimination of water from (R)-2-hydroxyglutaryl-CoA to glutaconyl-CoA.; Remark: C. symbiosum hgdB is part of the radicalic catalytic pathway, present in many Clostridium species,which enables those to ferment aminoacids.; Title: similarity to hypothetical 2-hydroxyglutaryl-CoA dehydratase hgdB - Clostridium symbiosum; See PMID 10491198; uncharacterized protein 2478657 84591070 An04g10180 Aspergillus niger uncharacterized protein XP_059599552.1 2478203 D 5061 CDS An04g10190 84591071 join(2480830..2480838,2480992..2481171,2481259..2481294) VI 1 NT_166539.1 hypothetical protein 2481294 84591071 An04g10190 Aspergillus niger hypothetical protein XP_059603689.1 2480830 D 5061 CDS An04g10200 84591072 join(2481306..2481480,2481584..2481608,2481645..2481785,2482125..2482578) VI 1 NT_166539.1 hypothetical protein 2482578 84591072 An04g10200 Aspergillus niger hypothetical protein XP_059603690.1 2481306 D 5061 CDS An04g10210 84591073 complement(join(2483447..2483636,2483705..2483880,2484061..2484179,2484229..2484418,2484495..2484584)) VI 1 NT_166539.1 hypothetical protein 2484584 84591073 An04g10210 Aspergillus niger hypothetical protein XP_059603691.1 2483447 R 5061 CDS An04g10230 4991424 join(2486960..2487107,2487217..2487293,2487384..2487497,2487527..2487668,2487966..2487995,2488080..2488172,2488486..2488631,2488933..2489453,2489530..2489866,2490000..2490058,2490174..2490534,2490622..2490924,2491165..2491304,2491340..2491376,2491413..2491493,2491555..2491860) VI 1 NT_166539.1 Title: similarity to hypothetical protein AAN66273.1 - Pseudomonas putida; uncharacterized protein 2491860 4991424 An04g10230 Aspergillus niger uncharacterized protein XP_059603692.1 2486960 D 5061 CDS An04g10240 84591074 join(2494486..2494624,2494694..2495613) VI 1 NT_166539.1 hypothetical protein 2495613 84591074 An04g10240 Aspergillus niger hypothetical protein XP_059603693.1 2494486 D 5061 CDS An04g10250 4991426 complement(join(2496280..2496656,2496716..2497136,2497268..2497285)) VI 1 NT_166539.1 Title: weak similarity to hypothetical protein encoded by An08g08870 - Aspergillus niger; uncharacterized protein 2497285 4991426 An04g10250 Aspergillus niger uncharacterized protein XP_001402379.3 2496280 R 5061 CDS An04g10260 84591075 complement(join(2497693..2497795,2497881..2498285,2498360..2498433)) VI 1 NT_166539.1 hypothetical protein 2498433 84591075 An04g10260 Aspergillus niger hypothetical protein XP_059603694.1 2497693 R 5061 CDS An04g10270 4991428 complement(join(<2498687..2498864,2498957..2499874,2500019..2500121,2500286..2500399)) VI 1 NT_166539.1 Remark: a putative sequencing error results in an frameshift.; Title: strong similarity to hypothetical protein FLJ10830 - Homo sapiens [putative frameshift]; putative frameshift; uncharacterized protein 2500399 4991428 An04g10270 Aspergillus niger uncharacterized protein XP_059603695.1 2498687 R 5061 CDS An04g10280 4991429 2501157..2502470 VI 1 NT_166539.1 Remark: The yeast S. cerevisiae expresses two phosphatidylserine decarboxylase (PSD) activities which are responsible for conversion of phosphatidylserine to phosphatidylethanolamine, and either enzyme alone is sufficient for normal cellular growth.; Title: weak similarity to phosphatidylserine decarboxylase Psd2 - Saccharomyces cerevisiae; See PMID 7890740; uncharacterized protein 2502470 4991429 An04g10280 Aspergillus niger uncharacterized protein XP_001402382.1 2501157 D 5061 CDS An04g10290 4991430 complement(join(2503778..2504110,2504175..2504431,2504493..2504724,2504778..2504804)) VI 1 NT_166539.1 Catalytic activity: R-CHOH-R' + NADP(+) <=> R-CO-R' + NADPH.; Remark: Acts on a wide range of carbonyl compounds,including quinones, aromatic aldehydes, ketoaldehydes,daunorubicin, and prostaglandins E and F, reducing them to the corresponding alcohol. B-specific with respect to NADPH.; Title: similarity to ketoreductase krd -Zygosaccharomyces rouxii; See PMID 10951208; uncharacterized protein 2504804 4991430 An04g10290 Aspergillus niger uncharacterized protein XP_059603696.1 2503778 R 5061 CDS An04g10300 4991431 join(2505573..2505612,2505705..2506093,2506151..2506442,2506493..2506629,2506672..2507032,2507112..2507122,2507350..2507424,2507594..2507698) VI 1 NT_166539.1 Title: strong similarity to hypothetical longevity-assurance protein 1 - Schizosaccharomyces pombe; uncharacterized protein 2507698 4991431 An04g10300 Aspergillus niger uncharacterized protein XP_059603697.1 2505573 D 5061 CDS An04g10320 4991433 join(2509525..2509551,2509608..2509637,2509850..2510212) VI 1 NT_166539.1 Function: quinone reductases are electron-transfer proteins.; Induction: the activity of QR in cultures of P. chrysosporium increased following the addition of 2-dimethoxybenzoquinone, vanillic acid, or several other aromatic compounds.; Similarity: the ORF shows strong similarity to minor allergens of the fungi A. alternata and C. herbarum and to trp repressor binding protein of E. coli.; Title: strong similarity to 1,4-benzoquinone reductase QR - Phanerochaete chrysosporium; See PMID 7898496; See PMID 8516330; See PMID 9925562; uncharacterized protein 2510212 4991433 An04g10320 Aspergillus niger uncharacterized protein XP_059603698.1 2509525 D 5061 CDS An04g10330 84591076 join(2511914..2512015,2512109..2512520,2512696..2512739) VI 1 NT_166539.1 hypothetical protein 2512739 84591076 An04g10330 Aspergillus niger hypothetical protein XP_059603699.1 2511914 D 5061 CDS An04g10340 4991435 join(2512964..2513075,2513143..2513563,2513724..2514005,2514061..2514200,2514239..2514827,2514883..2515405,2515456..2515611) VI 1 NT_166539.1 Catalytic activity: UDP-glucose + a sterol <=> UDP + an O-glucosylsterol.; Title: similarity to sterol glucosyltransferase ugt52 - Dictyostelium discoideum; See PMID 10224056; uncharacterized protein 2515611 4991435 An04g10340 Aspergillus niger uncharacterized protein XP_059603700.1 2512964 D 5061 CDS An04g10350 10098357 join(2516605..2516708,2516802..2516943,2517018..2517205,2517262..2517758,2517812..2518169,2518252..2518413,2518608..>2518909) VI 1 NT_166539.1 Function: efflux of the antibiotic cycloheximide by H+ antiport (TC 2. A. 1. 2. 2).; Remark: a putative sequencing error results in an frameshift.; Title: strong similarity to cycloheximide resistance protein CYHR - Candida maltosa [putative frameshift]; putative frameshift; See PMID 1628836; uncharacterized protein 2518909 10098357 An04g10350 Aspergillus niger uncharacterized protein XP_059603701.1 2516605 D 5061 CDS An04g10360 4991437 complement(join(2519526..2519945,2519999..2520328,2520382..2520585)) VI 1 NT_166539.1 Title: similarity to BCU0021 protein SEQ ID 8 from patent WO2003029421-A2 - Homo sapiens; uncharacterized protein 2520585 4991437 An04g10360 Aspergillus niger uncharacterized protein XP_001402390.1 2519526 R 5061 CDS An04g10370 84591077 join(2520708..2520764,2520976..2521154,2521212..2521261,2521384..2521474,2521517..2521702,2521771..2521993) VI 1 NT_166539.1 hypothetical protein 2521993 84591077 An04g10370 Aspergillus niger hypothetical protein XP_059603702.1 2520708 D 5061 CDS An04g10380 84591078 complement(join(2522089..2522283,2522396..2522467)) VI 1 NT_166539.1 hypothetical protein 2522467 84591078 An04g10380 Aspergillus niger hypothetical protein XP_059603703.1 2522089 R 5061 CDS An04g10390 84591079 join(2522538..2522599,2522678..2522822) VI 1 NT_166539.1 hypothetical protein 2522822 84591079 An04g10390 Aspergillus niger hypothetical protein XP_059603704.1 2522538 D 5061 CDS An04g10400 4991441 join(2522937..2523222,2523294..2523768,2523826..2524882) VI 1 NT_166539.1 Title: strong similarity to hypothetical brown 2 protein abr2 - Aspergillus fumigatus; uncharacterized protein 2524882 4991441 An04g10400 Aspergillus niger uncharacterized protein XP_001402394.1 2522937 D 5061 CDS An05g00010 4980753 join(1900..2778,2838..5283,5334..5501,5715..5782) VII 1 NT_166521.1 Title: weak similarity to cell differentiation protein LagC - Dictyostelium discoideum; uncharacterized protein 5782 4980753 An05g00010 Aspergillus niger uncharacterized protein XP_059603705.1 1900 D 5061 CDS An05g00020 4981002 complement(join(6023..7870,7909..8016)) VII 1 NT_166521.1 Remark: UME6 of S. cerevisiae is also called CAR80,NIM2, RIM16 or YDR207C.; Similarity: the similarity to UME6 of S. cerevisiae and other known or putative transcription factors is due to the presence of a fungal Zn(2) - Cys(6) binuclear cluster domain in the N-terminal region of the predicted protein; no other homology is present.; Title: weak similarity to transcription factor Ume6 - Saccharomyces cerevisiae; nucleus; uncharacterized protein 8016 4981002 An05g00020 Aspergillus niger uncharacterized protein XP_059603706.1 6023 R 5061 CDS An05g00030 84591080 complement(8475..9734) VII 1 NT_166521.1 hypothetical protein 9734 84591080 An05g00030 Aspergillus niger hypothetical protein XP_059603707.1 8475 R 5061 CDS An05g00040 4980739 10978..12483 VII 1 NT_166521.1 Title: weak similarity to leukocyte common antigen precursor CD45 - Rattus norvegicus; uncharacterized protein 12483 4980739 An05g00040 Aspergillus niger uncharacterized protein XP_001390578.1 10978 D 5061 CDS An05g00050 4980742 join(12740..12906,13000..14032,14084..14284) VII 1 NT_166521.1 Function: Prolidase of S. domuncula hydrolyzes the peptide bond that involves the imino nitrogen of proline or hydroxyproline; hence, it catalyzes the final step in collagen degradation.; Title: strong similarity to prolidase - Suberites domuncula; See PMID 10373628; uncharacterized protein 14284 4980742 An05g00050 Aspergillus niger uncharacterized protein XP_001390579.1 12740 D 5061 CDS An05g00060 4980747 complement(join(14798..15325,15381..15516,15612..15838)) VII 1 NT_166521.1 hypothetical protein 15838 4980747 An05g00060 Aspergillus niger hypothetical protein XP_001390580.1 14798 R 5061 CDS An05g00070 4980749 join(17338..17799,17865..17949,18052..18274,18333..18450,18496..18615,18678..18803,18877..18890,18943..19171,19230..19720,19774..19900) VII 1 NT_166521.1 Catalytic activity: leukotriene-A4 hydrolases catalyze the reaction: (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoa te (leukotriene A4) + H(2)O <=> (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tet raenoate (leukotriene B4).; Pathway: mouse leukotriene-A4 hydrolase is involved in leukotriene B4 biosynthesis which is a pro-inflammatory mediator in myeloid cells.; Similarity: the A. niger protein also shows strong similarity to Caenorhabditis elegans aminopeptidase.; Similarity: the A. niger protein also shows strong similarity to human leukotriene-A4 hydrolase a bifunctional cytosolic enzyme, which both hydrolyses leukotriene A4 (LTA4) into leukotriene B4 (LTB4) and exerts aminopeptidase activity against opioid peptides.; Title: strong similarity to leukotriene-A4 hydrolase - Mus musculus; See PMID 1710117; uncharacterized protein 19900 4980749 An05g00070 Aspergillus niger uncharacterized protein XP_001390581.1 17338 D 5061 CDS An05g00080 4980755 complement(join(20181..20698,20783..21119,21185..21253)) VII 1 NT_166521.1 Function: CBP3 of S. cerevisiae is required for the assembly of the respiratory chain complex coenzyme QH2-cytochrome c reductase.; Remark: the N-terminal 30% are not conserved between the A. niger protein and CBP3 of S. cerevisiae.; Title: similarity to membrane protein Cbp3 -Saccharomyces cerevisiae; See PMID 2544586; uncharacterized protein 21253 4980755 An05g00080 Aspergillus niger uncharacterized protein XP_001390582.1 20181 R 5061 CDS An05g00090 4980741 complement(join(22037..22150,22219..22609,22675..22970)) VII 1 NT_166521.1 Title: strong similarity to hypothetical protein YPR040w - Saccharomyces cerevisiae; uncharacterized protein 22970 4980741 An05g00090 Aspergillus niger uncharacterized protein XP_001390583.3 22037 R 5061 CDS An05g00100 4980743 join(23456..23551,23609..24565,24616..24756) VII 1 NT_166521.1 Localization: immunofluorescence studies using a specific antibody have shown that Aik is localized to the spindle pole during mitosis, especially from prophase through anaphase.; Similarity: human AIK shows strong similarity to Aurora of Drosophila and related S. cerevisiae Ipl1 kinase. These are required for normal chromosome segregation.; Title: strong similarity to aurora/IPL1-related kinase AIK - Homo sapiens; deleted EC_number 2.7.1.37; See PMID 9153231; uncharacterized protein 24756 4980743 An05g00100 Aspergillus niger uncharacterized protein XP_001390584.1 23456 D 5061 CDS An05g00110 4980756 complement(join(25014..25241,25306..25565,25650..25875)) VII 1 NT_166521.1 Similarity: the A. niger protein also shows similarity to human KUB3, a protein with unknown function that binds the DNA binding subunit of DNA-dependent protein kinase.; Title: strong similarity to hypothetical protein YNR020c - Saccharomyces cerevisiae; uncharacterized protein 25875 4980756 An05g00110 Aspergillus niger uncharacterized protein XP_001390585.1 25014 R 5061 CDS An05g00120 4980750 join(26198..26234,26309..26496,26562..26672,26727..26822,26882..27700) VII 1 NT_166521.1 Pathway: PRO1 catalyzes the first step in proline biosynthesis.; Similarity: PRO1 shows strong similarity to other to other glutamate 5-kinases.; Title: strong similarity to glutamate 5-kinase Pro1 - Saccharomyces cerevisiae; See PMID 1350780; uncharacterized protein 27700 4980750 An05g00120 Aspergillus niger uncharacterized protein XP_001390586.1 26198 D 5061 CDS An05g00130 4981001 complement(join(28307..28372,28466..28874,28970..29070,29137..29352)) VII 1 NT_166521.1 Function: yeast KRE9 gene encodes a 30-kDa secretory pathway protein involved in the synthesis of cell wall (1-->6)-beta-glucan.; Phenotype: disruption of KRE9 leads to serious growth impairment and an altered cell wall containing less than 20% of the wild-type amount of (1-->6)-beta-glucan.; Similarity: yeast KRE9 belongs to the KRE9 / KNH1 family.; Title: similarity to cell wall synthesis protein KRE9 - Candida albicans; extracellular/secretion proteins; See PMID 8413233; uncharacterized protein 29352 4981001 An05g00130 Aspergillus niger uncharacterized protein XP_001390587.3 28307 R 5061 CDS An05g00140 4980744 join(30045..30257,30371..31120) VII 1 NT_166521.1 Complex: the yeast signal recognition particle receptor is composed of the alpha and the beta chain.; Function: the signal recognition particle and its receptor target nascent secretory proteins to the ER.; Remark: YKL154w is the systematic name for SRP102,the gene encoding SRbeta.; Similarity: SRalpha and SRbeta are both members of the GTPase superfamily.; Title: similarity to signal recognition particle receptor beta chain Srp102 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 9679135; uncharacterized protein 31120 4980744 An05g00140 Aspergillus niger uncharacterized protein XP_001390588.1 30045 D 5061 CDS An05g00150 84591081 complement(join(31247..31569,31712..31898,31981..32092,32266..32380,32662..32737,32908..32967)) VII 1 NT_166521.1 hypothetical protein 32967 84591081 An05g00150 Aspergillus niger hypothetical protein XP_059603708.1 31247 R 5061 CDS An05g00160 4980748 complement(join(33191..33817,33873..34549,34614..34648,34721..35069,35197..35272)) VII 1 NT_166521.1 Function: yeast cystathionine beta-synthase converts serine and homocysteine to cystathionine.; Pathway: yeast CYS4 is involved in the sulfide incorporation and transsulfuration pathway.; Similarity: yeast CYS4 belongs to the cysteine synthase/cystathionine beta- synthase family.; Title: strong similarity to cystathionine beta-synthase Cys4 - Saccharomyces cerevisiae; See PMID 8017103; See PMID 8366024; uncharacterized protein 35272 4980748 An05g00160 Aspergillus niger uncharacterized protein XP_001390590.3 33191 R 5061 CDS An05g00170 4980746 join(37590..38422,38478..38774,38828..39125) VII 1 NT_166521.1 Function: the Hum1 protein of S. cerevisiae has been postulated to be involved in cellular adaption to elevated extracellular Ca2+ concentrations and to be a means to attenuate the propagation of Ca2+ signals in this organism.; Function: the Hum1 protein of S. cerevisiae is required for vacuolar Ca2+/H+ exchange.; Function: vacuolar membrane vesicles from hum1 S. cerevisiae mutants lack all Ca2+/H+ antiport activity,demonstrating that the Hum1 protein catalyzes the exchange of Ca2+ for H+ across the yeast vacuolar membrane.; Remark: Hum1 of S. cerevisiae is also called mnr1,vcx1, and YDL128w.; Title: strong similarity to vacuolar Ca(2+)/H+-exchanging protein Hum1 - Saccharomyces cerevisiae; vacuole; See PMID 8668190; See PMID 10219995; See PMID 10371152; uncharacterized protein 39125 4980746 An05g00170 Aspergillus niger uncharacterized protein XP_001390591.1 37590 D 5061 CDS An05g00180 4980745 join(39604..39684,39758..40003,40059..40541,40589..41224) VII 1 NT_166521.1 Title: similarity to hypothetical protein B13M15.020 - Neurospora crassa; uncharacterized protein 41224 4980745 An05g00180 Aspergillus niger uncharacterized protein XP_059603709.1 39604 D 5061 CDS An05g00190 4980740 42063..42812 VII 1 NT_166521.1 Function: yeast PCL7 is a cylin like protein that interacts with the Cdk PHO85. This PHO85/PCL7 complex phosphorylates Pho4p in vitro.; Remark: YIL050w is the systematic name for PCL7.; Remark: the similarity of the A. niger protein to PCL7 is restricted to the C-terminus and contains the cyclin box.; Remark: yeast PCL7 expression is constant during cell cycle.; Title: similarity to cyclin like protein Pcl7 -Saccharomyces cerevisiae; See PMID 9032248; See PMID 9520600; uncharacterized protein 42812 4980740 An05g00190 Aspergillus niger uncharacterized protein XP_001390593.1 42063 D 5061 CDS An05g00200 4980751 join(43828..44118,44206..45009,45071..45143,45243..45507,45563..45675,45727..46376) VII 1 NT_166521.1 Function: yeast AKR1 affects the kinase cascade downstream of Gbetagamma.; Function: yeast AKR1 has a negative effect on signaling in the pheromone pathway.; Function: yeast AKR1 may be involved in coupling the activities of a Bem1p-Cdc24p-Cdc42p complex to an upstream signaling system, the pheromone-responsive G protein.; Remark: YDR264C is the systematic name for AKR1.; Title: strong similarity to ankyrin repeat-containing protein Akr1 - Saccharomyces cerevisiae; See PMID 8524293; See PMID 8649369; See PMID 9243510; uncharacterized protein 46376 4980751 An05g00200 Aspergillus niger uncharacterized protein XP_059603710.1 43828 D 5061 CDS An05g00210 84591082 join(48155..48226,48322..48365,48469..48543,48664..48740,49000..49119,49225..49305,49548..49646,49896..50002) VII 1 NT_166521.1 hypothetical protein 50002 84591082 An05g00210 Aspergillus niger hypothetical protein XP_059603711.1 48155 D 5061 CDS An05g00220 4980758 complement(join(50871..51504,51562..52376)) VII 1 NT_166521.1 Catalytic activity: psbA is involved in the conversion of L-Orn to its N(5)-OH derivative.; Function: D-N(5)-hydroxyornithine (D-N(5)-OH-Orn) is the hydroxamate ligand of the fluorescent siderophore Pseudobactin(B10).; Function: fluorescent siderophores play a role in biocontrol of deleterious rhizomicroorganisms.; Pathway: psbA is involved in D-N(5)-hydroxyornithine (D-N(5)-OH-Orn) synthesis.; Phenotype: The L-Orn N(5)-hydroxylase-defective mutants of Pseudomonas strain B10 were much less effective than the parental strains in suppressing the growth of the phytopathogen Erwinia carotovora in iron-poor medium.; Title: strong similarity to L-ornithine N5-hydroxylase psbA - Pseudomonas sp.; See PMID 11029447; uncharacterized protein 52376 4980758 An05g00220 Aspergillus niger uncharacterized protein XP_001390596.3 50871 R 5061 CDS An05g00230 84591083 join(52521..52614,52889..53023,53108..53181) VII 1 NT_166521.1 hypothetical protein 53181 84591083 An05g00230 Aspergillus niger hypothetical protein XP_059603712.1 52521 D 5061 CDS An05g00240 84591084 complement(join(53938..54176,54381..54543)) VII 1 NT_166521.1 hypothetical protein 54543 84591084 An05g00240 Aspergillus niger hypothetical protein XP_059603713.1 53938 R 5061 CDS An05g00250 84591085 join(54823..55154,55212..55221,55395..55469,55864..56082,56339..56392) VII 1 NT_166521.1 hypothetical protein 56392 84591085 An05g00250 Aspergillus niger hypothetical protein XP_059603714.1 54823 D 5061 CDS An05g00260 84591086 complement(join(57063..57178,57335..57464,57593..57664)) VII 1 NT_166521.1 hypothetical protein 57664 84591086 An05g00260 Aspergillus niger hypothetical protein XP_059603715.1 57063 R 5061 CDS An05g00270 84591087 join(60560..60609,60840..61449) VII 1 NT_166521.1 hypothetical protein 61449 84591087 An05g00270 Aspergillus niger hypothetical protein XP_059603716.1 60560 D 5061 CDS An05g00280 4980764 join(61828..64287,64358..65089) VII 1 NT_166521.1 Function: SWE1 is a protein kinase that acts both on serines and on tyrosines.; Function: SWE1 is able to phosphorylate Cdc28p on tyrosine and inhibit its activity.; Remark: the similarity of the A. niger protein to SWE1 of S. cerevisiae is restricted to the C-terminal half of the A. niger protein which is about 200 amino acids longer than SWE1.; Title: similarity to protein kinase Swe1 -Saccharomyces cerevisiae; See PMID 8253069; uncharacterized protein 65089 4980764 An05g00280 Aspergillus niger uncharacterized protein XP_001390602.1 61828 D 5061 CDS An05g00290 4980765 66426..69812 VII 1 NT_166521.1 Phenotype: the cdc28-P8 mutant accumulates unspliced precursors at the restrictive temperature. Consistent with this phenotype is the similarity to the Prp2, Prp16, and Prp22 proteins from budding yeast, which are required for the splicing of mRNA precursors.; Phenotype: the fission-yeast gene cdc28+ was originally identified in a screen for temperature-sensitive mutants that exhibit a cell-division cycle arrest and was found to be required for mitosis.; Title: strong similarity to ATP-dependent RNA helicase cdc28p - Schizosaccharomyces pombe; nucleus; See PMID 8862522; uncharacterized protein 69812 4980765 An05g00290 Aspergillus niger uncharacterized protein XP_001390603.1 66426 D 5061 CDS An05g00300 4980766 join(70292..70468,70645..70722) VII 1 NT_166521.1 Function: cytochrome b5 is a membrane bound hemoprotein which functions as an electron carrier for several membrane bound oxygenases.; Localization: microsomal membrane. bound to the cytoplasmic side of the endoplasmic reticulum.; Remark: the A. niger also shows similarity to mitochondrial L-lactate dehydrogenase (cytochrome) of s. cerevisiae, which is about 5 times longer than the A. niger protein.; Title: similarity to microsomal cytochrome b5 cytb5 - Musca domestica; endoplasmatic reticulum; See PMID 8900138; uncharacterized protein 70722 4980766 An05g00300 Aspergillus niger uncharacterized protein XP_001390604.1 70292 D 5061 CDS An05g00310 4980767 complement(join(71079..71896,71956..74980)) VII 1 NT_166521.1 Title: strong similarity to hypothetical nuclear migration protein - Neurospora crassa; uncharacterized protein 74980 4980767 An05g00310 Aspergillus niger uncharacterized protein XP_001390605.1 71079 R 5061 CDS An05g00320 84591088 join(75003..75008,75056..75238,75279..75456,75639..75764,75848..76041) VII 1 NT_166521.1 hypothetical protein 76041 84591088 An05g00320 Aspergillus niger hypothetical protein XP_059603717.1 75003 D 5061 CDS An05g00330 84591089 complement(77319..77567) VII 1 NT_166521.1 hypothetical protein 77567 84591089 An05g00330 Aspergillus niger hypothetical protein XP_059603718.1 77319 R 5061 CDS An05g00340 4980770 79234..80040 VII 1 NT_166521.1 Catalytic activity: cis-epoxysuccinate hydrolase catalyses the reaction cis-epoxysuccinate + H(2)O = L(+) tartaric acid.; Remark: epoxides are used as chiral building blocks in the organic synthesis of fine chemicals, especially enantiomerically pure compounds.; Remark: tartaric acid is used in the food industry as an additive in soft drinks, a food preservative and a raw material for the synthesis of emulsifiers.; Remark: the use of cis-epoxysuccinate hydrolase in the production of tartaric acid precludes contamination of L(+) tartaric acid with the D(+) form, which is considered harmful to humans.; Similarity: the predicted A. niger protein shows strong similarity to the cis-epoxysuccinate hydrolase (LMGP-18079) of patent EP911392-A1 (AC# AAY04477) from R. rhodochrous. the best blastP match is the conserved hypothetical protein B11N2. 300 from N. crassa.; Title: strong similarity to cis-epoxysuccinate hydrolase (LMGP-18079) from patent EP911392-A1 -Rhodococcus rhodochrous; uncharacterized protein 80040 4980770 An05g00340 Aspergillus niger uncharacterized protein XP_001390608.1 79234 D 5061 CDS An05g00350 4980771 join(80439..80450,80508..>81409) VII 1 NT_166521.1 Remark: a putative frameshift results in a premature STOP codon.; Remark: the patent does not provide further information about the function of the protein.; Similarity: the predicted A. niger protein shows strong similarity to the protein sequence of fragment SEQ ID NO: 4378 of patent EP1033405-A2 (AC# AAG07282) and hypothetical proteins from diverse procaryotic and eucaryotic species.; Title: strong similarity to protein fragment SEQ ID NO:4378 from patent EP1033405-A2 - Arabidopsis thaliana [putative frameshift]; putative frameshift; uncharacterized protein 81409 4980771 An05g00350 Aspergillus niger uncharacterized protein XP_001390609.3 80439 D 5061 CDS An05g00360 84591090 join(83108..83123,83298..83494,85014..85222,85556..85576,86117..86390) VII 1 NT_166521.1 hypothetical protein 86390 84591090 An05g00360 Aspergillus niger hypothetical protein XP_059603719.1 83108 D 5061 CDS An05g00370 4980773 join(87812..87889,87962..88609) VII 1 NT_166521.1 Function: the signal transduction pathway mediated by the N. crassa ras2 protein regulates the apical growth of hyphae, cell wall synthesis, and conidial formation in N. crassa.; Phenotype: smco7 mutant exhibits very slow hyphal growth and the rate of conidial formation was approximately one two-hundredth of wild type.; Remark: the N. crassa ras2 disruptant shows morphological characteristics very similar to those of the smco7 mutant, which also maps to linkage group V. the smco7 mutant harbored a single base deletion in the NC-ras2 gene, which is predicted to result in the truncation of the protein product. smco7 mutation causes both the changes in the pattern of hyphal growth and the defects in cell wall synthesis.; Similarity: the predicted A. niger protein shows strong similarity to the ras-2 protein of N. crassa, which belongs to the ras subfamily of small GTP-binding proteins.; Title: strong similarity to protein ras-2 -Neurospora crassa; See PMID 9180696; uncharacterized protein 88609 4980773 An05g00370 Aspergillus niger uncharacterized protein XP_001390611.1 87812 D 5061 CDS An05g00380 84591091 complement(88803..89408) VII 1 NT_166521.1 hypothetical protein 89408 84591091 An05g00380 Aspergillus niger hypothetical protein XP_059603720.1 88803 R 5061 CDS An05g00390 4980775 join(91105..91483,91550..91945,92006..92884,92946..93364) VII 1 NT_166521.1 Catalytic activity: acetyl coenzyme A synthetase of T. pyriformis catalyses the reaction ATP + acetate + CoA = AMP + pyrophosphate + acetyl-CoA.; Pathway: acetyl coenzyme A synthetase of T. pyriformis is involved in glycolysis / gluconeogenesis,pyruvate / propanoate metabolism and in the reductive carboxylate cycle (CO2 fixation).; Regulation: expression of the acetyl-CoA synthetase gene in Tetrahymena cells was dramatically decreased at 30 min after end of heat treatment (EHT) prior to entering synchronous cell division (which occurs 75 min after EHT).; Remark: acetyl coenzyme A synthetase of T. pyriformis also acts on propanoate and propenoate.; Similarity: the predicted A. niger protein shows strong similarity to the acetyl coenzyme A synthetase of T. pyriformis and other acetyl coenzyme A synthetases from procaryotic and eucaryotic species.; Title: strong similarity to acetyl coenzyme A synthase - Tetrahymena pyriformis; See PMID 10510317; uncharacterized protein 93364 4980775 An05g00390 Aspergillus niger uncharacterized protein XP_001390613.1 91105 D 5061 CDS An05g00400 84591092 complement(93981..>94574) VII 1 NT_166521.1 Remark: N-terminally truncated ORF due to end of contig.; Similarity: similarity of the predicted A. niger protein to DNA-directed RNA polymerase and various other protein sequences is due to low complexity sequences, which consist of serine, alanine and proline.; Title: weak similarity to amphiphysin IIc1 - Homo sapiens [truncated ORF]; See PMID 9603201; uncharacterized protein 94574 84591092 An05g00400 Aspergillus niger uncharacterized protein XP_059603721.1 93981 R 5061 CDS An05g00410 4980777 join(96113..96283,96391..96447,96503..96596,96653..96790,96843..97987) VII 1 NT_166521.1 Catalytic activity: 5,10-methylenetetrahydrofolate + glycine + H(2)O <=> tetrahydrofolate + L-serine.; Cofactor: pyridoxal phosphate.; Function: the serine hydroxymethyltransferase, a pyridoxal phosphate-dependent enzyme, catalyses the interconversion of serine and glycine.; Pathway: the serine hydroxymethyltransferase is involved in the Glycine, serine and threonine metabolism and in the Lysine degradation.; Remark: in eukaryotes there are two forms of the enzymes: a cytosolic one and a mitochondrial one.; Title: strong similarity to serine hydroxymethyl-transferase I Shm1 - Candida albicans; See PMID 10641038; uncharacterized protein 97987 4980777 An05g00410 Aspergillus niger uncharacterized protein XP_001390615.1 96113 D 5061 CDS An05g00420 4980778 join(98303..99653,99709..99731) VII 1 NT_166521.1 Title: similarity to human ORFX ORF1903 polypeptide sequence SEQ ID NO:3806 from patent WO200058473-A2 - Homo sapiens; uncharacterized protein 99731 4980778 An05g00420 Aspergillus niger uncharacterized protein XP_059600734.1 98303 D 5061 CDS An05g00430 4980779 join(99943..100038,100105..100179,100231..100369,100512..100660) VII 1 NT_166521.1 Title: similarity to hypothetical competence-damage inducible protein CinA - Streptococcus pyogenes; uncharacterized protein 100660 4980779 An05g00430 Aspergillus niger uncharacterized protein XP_059600735.1 99943 D 5061 CDS An05g00440 10098138 join(100959..100991,101098..101473,101536..102112,102204..103362,103612..103958,104215..105001,105057..106379) VII 1 NT_166521.1 Remark: the extracted coding region has N-terminal no homologies.; Title: strong similarity to human transmembrane protein from patent WO200056891-A2 - Homo sapiens; plasma membrane; uncharacterized protein 106379 10098138 An05g00440 Aspergillus niger uncharacterized protein XP_003188684.2 100959 D 5061 CDS An05g00450 84591093 complement(join(106481..106622,106692..107533)) VII 1 NT_166521.1 Function: Rev1 of H. sapiens is involved in translesion repair together with the DNA polymerase zeta.; Remark: normally, the replication fork stops at (e. g. UV-induced) DNA mismatches. Translesion repair, however,is a mechanism to overcome this replication blockage.; Remark: the ORF is much shorter than Rev1 of H. sapiens (327 compared to 1250 amino acids) and the similarity between the two proteins is restricted to a stretch of about 100 amino acids. However, the ORF shows weak similarity to Rev1 of several species.; Title: weak similarity to translesion repair protein Rev1 - Homo sapiens; See PMID 11485998; uncharacterized protein 107533 84591093 An05g00450 Aspergillus niger uncharacterized protein XP_059600736.1 106481 R 5061 CDS An05g00460 84591094 complement(join(108252..108281,108325..108399)) VII 1 NT_166521.1 Remark: the ORF is extremely short in length (34 amino acids).; Title: questionable ORF; uncharacterized protein 108399 84591094 An05g00460 Aspergillus niger uncharacterized protein XP_059600737.1 108252 R 5061 CDS An05g00470 84591095 complement(join(115511..115750,115847..115904,116135..116148)) VII 1 NT_166521.1 Remark: the ORF has an unusual exon/intron structure.; hypothetical protein 116148 84591095 An05g00470 Aspergillus niger hypothetical protein XP_059600738.1 115511 R 5061 CDS An05g00478 84591096 join(121983..122076,122348..122580) VII 1 NT_166521.1 hypothetical protein 122580 84591096 An05g00478 Aspergillus niger hypothetical protein XP_059600739.1 121983 D 5061 CDS An05g00480 4980785 join(123927..124197,124258..124458,124513..124645,124704..126042) VII 1 NT_166521.1 Function: stuA of A. nidulans is a transcription factor, regulating the orderly differentiation and spatial organization of the conidiophore cell types.; Induction: transription of stuA mRNA increases in A. nidulans approximately 50-fold during the establishment of developmental competence.; Title: strong similarity to transcription factor involved in differentiation stuA - Aspergillus nidulans; nucleus; See PMID 1516832; See PMID 9312029; uncharacterized protein 126042 4980785 An05g00480 Aspergillus niger uncharacterized protein XP_001390623.3 123927 D 5061 CDS An05g00490 4980786 complement(join(127116..128233,128311..128431,128677..128778,128885..129301,129362..129552,129607..130341,130426..130597)) VII 1 NT_166521.1 Function: itr2 of S. pombe is a transporter for myo-inositol.; Phenotype: S. pombe mutants of itr2 are defective in inositol transport.; Remark: itr2 of S. pombe belongs to the sugar transporter family.; Remark: itr2 of S. pombe is also called SPAC20G8. 03.; Repression: itr2 of S. pombe is repressed by glucose.; Similarity: the ORF is longer than itr2 of S. pombe (951 compared to 557 amino acids).; Title: strong similarity to myo-inositol transporter 2 itr2p - Schizosaccharomyces pombe; See PMID 9560432; uncharacterized protein 130597 4980786 An05g00490 Aspergillus niger uncharacterized protein XP_001390624.3 127116 R 5061 CDS An05g00500 4980787 join(131587..131692,131761..133244) VII 1 NT_166521.1 Catalytic activity: P450rm of R. minuta catalyzes the formation of isobutene from isovalerate.; Pathway: P450rm of R. minuta is involved in the 4-hydroxylation of benzoate.; Remark: P450rm of R. minuta belongs to the cytochrome P450 family.; Title: strong similarity to benzoate 4-hydroxylase P450rm - Rhodotorula minuta; See PMID 8882724; uncharacterized protein 133244 4980787 An05g00500 Aspergillus niger uncharacterized protein XP_001390625.1 131587 D 5061 CDS An05g00510 4980788 134295..136445 VII 1 NT_166521.1 Function: NADP-cytochrome reductases catalyse the reduction of heme-thiolate-dependent monooxygenases.; Induction: cprA of A. niger is induced by benzoic acid, which is the substrate of bphA.; Pathway: cprA of A. niger is (together with bphA) part of the para-hydroxylation of benzoate.; Title: strong similarity to NADPH cytochrome P450 oxidoreductase cprA - Aspergillus niger; See PMID 10852481; See PMID 7646819; uncharacterized protein 136445 4980788 An05g00510 Aspergillus niger uncharacterized protein XP_001390626.1 134295 D 5061 CDS An05g00520 4980789 complement(join(138606..139170,139217..140110,140163..140823,140858..141647)) VII 1 NT_166521.1 Function: RNA helicase A is an abundant nuclear enzyme of human cells that unwinds double-stranded RNA in a 3' to 5' direction.; Function: the function of the RNA helicase A gene has been categorized as chromatin binding/helicase/double-stranded RNA binding.; Remark: DDX9 of H. sapiens is also called NDH2 or DEAD-box protein 9.; Remark: the maleless mle gene is one of four known regulatory loci required for increased transcription (dosage compensation) of X-linked genes in D. melanogaster males.; Remark: the predicted A. niger protein contains two DEAD/DEAH box helicase motivs (PF00270, aa 675-708,740-841) of the DEAD and DEAH box helicases family,involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.; Similarity: the ORF shows also similarity to DNA or DNA/RNA helicases.; Title: strong similarity to RNA helicase A DDX9 -Homo sapiens; nucleus; See PMID 1653648; uncharacterized protein 141647 4980789 An05g00520 Aspergillus niger uncharacterized protein XP_059600740.1 138606 R 5061 CDS An05g00530 4980790 join(142334..142403,142441..144305,144369..145053,145109..145303,145360..149184,149242..149813,149867..150424) VII 1 NT_166521.1 Induction: phosphorylation of the translation initiation factor eIF2 by protein kinase GCN2 leads to increased translation of the transcriptional activator GCN4 in amino acid-starved cells.; Remark: the H. sapiens HsGCN1 protein shows strong similarity and functional relationship to the yeast orthologue GCN1, which serves as a component of a protein complex required for the stimulation of GCN2 kinase activity under starvation conditions and where the most investigations have taken place.; Title: strong similarity to translational regulator HsGCN1 - Homo sapiens; cytoplasm; See PMID 11350982; See PMID 9234705; uncharacterized protein 150424 4980790 An05g00530 Aspergillus niger uncharacterized protein XP_059600741.1 142334 D 5061 CDS An05g00540 84591097 join(151268..151572,151703..151853,151988..152137) VII 1 NT_166521.1 Remark: the systematical name of the S. cerevisiae L19 gene is YBL0424.; Similarity: the predicted A. niger protein shows a domain nearly identical with the ribosomal protein L19e motiv PF01280 (aa 13 - 160).; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L19 - Saccharomyces cerevisiae; cytoplasm; See PMID 11551941; See PMID 7725803; 60S ribosomal protein eL19 152137 84591097 An05g00540 Aspergillus niger 60S ribosomal protein eL19 XP_001390629.3 151268 D 5061 CDS An05g00550 4980792 complement(154002..155339) VII 1 NT_166521.1 hypothetical protein 155339 4980792 An05g00550 Aspergillus niger hypothetical protein XP_001390630.3 154002 R 5061 CDS An05g00560 84591098 join(155669..155963,156824..157095) VII 1 NT_166521.1 hypothetical protein 157095 84591098 An05g00560 Aspergillus niger hypothetical protein XP_059600742.1 155669 D 5061 CDS An05g00570 4980794 join(157746..157770,158126..159546,159613..159879) VII 1 NT_166521.1 Title: strong similarity to hypothetical protein CAD60747.1 - Podospora anserina; uncharacterized protein 159879 4980794 An05g00570 Aspergillus niger uncharacterized protein XP_001390632.1 157746 D 5061 CDS An05g00580 84591099 complement(join(161756..161770,162100..162153,162271..162354,162403..162491,162596..162743,162950..163011,163382..163481)) VII 1 NT_166521.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 163481 84591099 An05g00580 Aspergillus niger uncharacterized protein XP_059600743.1 161756 R 5061 CDS An05g00590 84591100 complement(join(164486..164508,164540..164622,164719..164772,164874..>164905)) VII 1 NT_166521.1 Remark: the ORF is truncated and contains no start-codon due to the border of the contig.; Title: questionable ORF [truncated ORF]; uncharacterized protein 164905 84591100 An05g00590 Aspergillus niger uncharacterized protein XP_059600744.1 164486 R 5061 CDS An05g00600 84591101 169373..170113 VII 1 NT_166521.1 Similarity: some local weak similarity to unrelated proteins with completely different lengths.; Title: similarity to hypothetical protein encoded by An06g02450 - Aspergillus niger; uncharacterized protein 170113 84591101 An05g00600 Aspergillus niger uncharacterized protein XP_059600745.1 169373 D 5061 CDS An05g00610 4980798 join(170566..171746,171836..171916,171973..172172,172228..172774,172845..173061) VII 1 NT_166521.1 Similarity: the prnA protein of A. nidulans is a transcriptional activator containing a fungal Zn binuclear cluster; the predicted ORF have not such functional domain.; Title: weak similarity to transcription activator prnA - Aspergillus nidulans; See PMID 9622360; uncharacterized protein 173061 4980798 An05g00610 Aspergillus niger uncharacterized protein XP_059600746.1 170566 D 5061 CDS An05g00620 84591102 complement(join(175117..175278,175323..175363,175530..175710,175755..175931)) VII 1 NT_166521.1 Similarity: the protein contains three PROSITE motifs with functional significance, but no protein known to contain such functional domains shows similarity to the predicted ORF.; hypothetical protein 175931 84591102 An05g00620 Aspergillus niger hypothetical protein XP_059600747.1 175117 R 5061 CDS An05g00625 4980800 176066..181480 VII 1 NT_166521.1 Title: weak similarity to hypothetical protein isof - Caenorhabditis elegans; uncharacterized protein 181480 4980800 An05g00625 Aspergillus niger uncharacterized protein XP_059600748.1 176066 D 5061 CDS An05g00630 4980801 181660..193122 VII 1 NT_166521.1 Similarity: the relatively significant BLASTP scores are due to the exceptional lenght of the predicted protein; the alignments are very bad and mainly due to the relative high content of low-complexity region; no BLASTP hit can be considered significant.; Title: strong similarity to hypothetical protein AAN10358.2 - Drosophila melanogaster; uncharacterized protein 193122 4980801 An05g00630 Aspergillus niger uncharacterized protein XP_001390639.3 181660 D 5061 CDS An05g00635 84591103 193280..194737 VII 1 NT_166521.1 hypothetical protein 194737 84591103 An05g00635 Aspergillus niger hypothetical protein XP_059600749.1 193280 D 5061 CDS An05g00640 4980803 join(195994..196406,196463..198493,198559..198761,198864..198934) VII 1 NT_166521.1 Function: ALR2 of S. cerevisiae mediates the transport of Mg2+ and other divalent cations.; Function: overexpression of ALR2 of S. cerevisiae confers resistance to aluminum ion.; Remark: ALR2 of S. cerevisiae is also called YFL050C.; Similarity: the N-terminal part of the predicted ORF shows no similarity to ALR2 and other proteins.; Title: strong similarity to divalent cation transprter Alr2 - Saccharomyces cerevisiae; plasma membrane; See PMID 10220002; See PMID 9430719; uncharacterized protein 198934 4980803 An05g00640 Aspergillus niger uncharacterized protein XP_001390641.1 195994 D 5061 CDS An05g00650 84591104 complement(join(199803..199959,200068..200167,200271..200376)) VII 1 NT_166521.1 hypothetical protein 200376 84591104 An05g00650 Aspergillus niger hypothetical protein XP_059600750.1 199803 R 5061 CDS An05g00660 84591105 complement(join(200406..200573,200660..200725,200827..200871,200912..200983)) VII 1 NT_166521.1 hypothetical protein 200983 84591105 An05g00660 Aspergillus niger hypothetical protein XP_059600751.1 200406 R 5061 CDS An05g00670 4980806 201254..204028 VII 1 NT_166521.1 Similarity: the similarity to VAC7 of S. cerevisiae involves only the C-terminal third of the predicted protein and the alignment contains 25% of gaps.; Title: weak similarity to vacuolar protein Vac7 -Saccharomyces cerevisiae; See PMID 9700156; See PMID 9763421; See PMID 8929562; See PMID 9372916; uncharacterized protein 204028 4980806 An05g00670 Aspergillus niger uncharacterized protein XP_001390644.1 201254 D 5061 CDS An05g00680 84591106 join(205772..205794,205834..205865,206032..206084,206144..206161,206240..206323) VII 1 NT_166521.1 Title: questionable ORF; uncharacterized protein 206323 84591106 An05g00680 Aspergillus niger uncharacterized protein XP_059600752.1 205772 D 5061 CDS An05g00690 4980808 complement(join(206602..207029,207132..207425,207484..209275)) VII 1 NT_166521.1 Title: strong similarity to hypothetical protein EAA58367.1 - Aspergillus nidulans; uncharacterized protein 209275 4980808 An05g00690 Aspergillus niger uncharacterized protein XP_059600753.1 206602 R 5061 CDS An05g00700 84591107 join(209409..209490,209566..209727,209819..209904) VII 1 NT_166521.1 hypothetical protein 209904 84591107 An05g00700 Aspergillus niger hypothetical protein XP_059600754.1 209409 D 5061 CDS An05g00710 84591108 complement(join(210020..210136,210311..210365,210482..210585,210719..210802,210856..210902,211078..211233,211307..211478,211534..211722)) VII 1 NT_166521.1 hypothetical protein 211722 84591108 An05g00710 Aspergillus niger hypothetical protein XP_059600755.1 210020 R 5061 CDS An05g00720 4980811 join(212568..213203,213289..214457,214503..214764) VII 1 NT_166521.1 Function: the facB gene of A. nidulans is a major regulatory gene involved in acetamide and acetate utilisation.; Similarity: the ORF shows similarity to several transcription factors with unknown fucntion.; Similarity: the similarity of the ORF to facB of A. nidulans is restricted to the N-terminal part, ending with amino acid 262 of the ORF.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; See PMID 9524126; See PMID 10483720; uncharacterized protein 214764 4980811 An05g00720 Aspergillus niger uncharacterized protein XP_059600756.1 212568 D 5061 CDS An05g00730 4980812 complement(join(215176..215223,215271..215322,215422..215553,215651..215756,215858..215971,216050..216189,216242..216320,216442..216451,216507..216558,216613..217041,217102..217292,217345..217406,217455..217482,217552..217611)) VII 1 NT_166521.1 Induction: S. cerevisiae HXT genes are inducible by glucose.; Remark: S. cerevisiae has 20 genes for known or putative hexose transporters.; Repression: S. cerevisiae HXT gene transcription is repressed in the absence of glucose.; Title: strong similarity to hexose transporter Hxt3 - Saccharomyces cerevisiae; plasma membrane; See PMID 10477308; See PMID 7862149; uncharacterized protein 217611 4980812 An05g00730 Aspergillus niger uncharacterized protein XP_059600757.1 215176 R 5061 CDS An05g00740 84591109 complement(join(217715..217811,217969..218000,218152..218262,218481..218573,218672..218758)) VII 1 NT_166521.1 Remark: the ORF has a suboptimal intron-exon structure.; hypothetical protein 218758 84591109 An05g00740 Aspergillus niger hypothetical protein XP_059600758.1 217715 R 5061 CDS An05g00750 4980814 complement(join(220518..220557,220623..220807,220874..220966,221456..221458)) VII 1 NT_166521.1 Remark: ribosomal protein L41 of C. utilis is also called 60S ribosomal protein L44.; Remark: the 56th amino acid residue of L41 is responsible for the ribosome inhibitor cycloheximide sensitivity of various organisms.; Similarity: the ORF overlaps with A. niger ESTs an_3001 database entry EMBLEST:BE758800, an_3087 entry EMBLEST:BE758839 and PATENTDNA:AAF11322 EST SEQ ID NO:3845.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L41 - Candida utilis; cytoplasm; See PMID 1729213; 60S ribosomal protein eL42 221458 4980814 An05g00750 Aspergillus niger 60S ribosomal protein eL42 XP_001390652.1 220518 R 5061 CDS An05g00760 4980815 complement(join(221727..222355,222451..222769)) VII 1 NT_166521.1 Title: strong similarity to hypothetical protein EAA57966.1 - Aspergillus nidulans; uncharacterized protein 222769 4980815 An05g00760 Aspergillus niger uncharacterized protein XP_059600759.1 221727 R 5061 CDS An05g00770 4980816 join(223363..223373,223450..223504,223692..223774,223870..223957) VII 1 NT_166521.1 Remark: due to the presence of a ribosomal protein L41 homologue (ORF 42CK) in proximity to this ORF, it is suggested that this region of the sequence was originally similar to known genes, which produce precursor proteins consisting of a single copy of ubiquitin fused to a C-terminal extension protein (CEP), e. g. ribosomal protein S27a.; Remark: pub2 of A. thaliana is also called ubiquitin-like protein 7, UBQ10 or PUB1.; Similarity: the ORF is half as long as the polyubiquitin 2 of A. thaliana, therefore it contains only one ubiquitin unit.; Title: strong similarity to polyubiquitin 2 PUb2 -Arabidopsis thaliana; See PMID 2538756; uncharacterized protein 223957 4980816 An05g00770 Aspergillus niger uncharacterized protein XP_001390654.1 223363 D 5061 CDS An05g00780 4980817 complement(join(224607..225551,225628..225704,225771..225828)) VII 1 NT_166521.1 Function: Ela1 of S. cerevisiae is an transcription elongation factor, which is necessary for RNA elongation from the RNA polymerase II promoter.; Remark: Ela1 of S. cerevisiae is also called YNL230C or N116.; Title: similarity to transcription elongation factor Ela1 - Saccharomyces cerevisiae; See PMID 10430890; uncharacterized protein 225828 4980817 An05g00780 Aspergillus niger uncharacterized protein XP_001390655.1 224607 R 5061 CDS An05g00790 4980818 join(226886..226890,226948..227047,227100..227421,227478..227523,227573..228090,228141..>228235) VII 1 NT_166521.1 Function: nodulin proteins are induced during a symbiotic plant-microbe interaction process and GmNOD53b of G. max is probably involved in cell-cell contact.; Induction: the expression of GmNOD53b of G. max coincides with the onset of nitrogen fixation.; Remark: the ORF is C-terminally truncated due to contig border.; Title: strong similarity to nodulin GmNOD53b -Glycine max [truncated ORF]; See PMID 10065559; See PMID 2279354; uncharacterized protein 228235 4980818 An05g00790 Aspergillus niger uncharacterized protein XP_001390656.3 226886 D 5061 CDS An05g00800 84591110 join(<228337..228424,228496..228659) VII 1 NT_166521.1 Remark: the N-terminal part of the ORF lies on the adjacent contig An05c0030 as ORF An05g00790.; Remark: the ORF is N-terminally truncated due to contig border.; Title: similarity to nodulin GmNOD53b - Glycine max [truncated ORF]; uncharacterized protein 228659 84591110 An05g00800 Aspergillus niger uncharacterized protein XP_059600760.1 228337 D 5061 CDS An05g00810 4980820 join(229560..229727,229786..229872,229956..230057) VII 1 NT_166521.1 Function: tbca of O. cuniculus participates in the tubulin folding process by interacting with a folding intermediate of beta-tubulin.; Remark: is also called TCP1-chaperonin cofactor A,tubulin-folding cofactor or CFA.; Similarity: the ORF overlaps with A. niger EST an_2839 database entry EMBLEST:BE759901.; Title: similarity to tubulin-specific chaperone A TBCA - Oryctolagus cuniculus; uncharacterized protein 230057 4980820 An05g00810 Aspergillus niger uncharacterized protein XP_001390658.1 229560 D 5061 CDS An05g00820 4980821 complement(join(230233..231203,231258..231294)) VII 1 NT_166521.1 Title: similarity to hypothetical protein SPCC24B10.11c - Schizosaccharomyces pombe; uncharacterized protein 231294 4980821 An05g00820 Aspergillus niger uncharacterized protein XP_001390659.1 230233 R 5061 CDS An05g00830 4980822 join(231329..231452,231616..231770,231859..233148) VII 1 NT_166521.1 Title: similarity to hypothetical protein T12G13.60 - Arabidopsis thaliana; uncharacterized protein 233148 4980822 An05g00830 Aspergillus niger uncharacterized protein XP_059600761.1 231329 D 5061 CDS An05g00840 84591111 join(233283..233368,233605..233689,233802..233829,233879..234090) VII 1 NT_166521.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF; uncharacterized protein 234090 84591111 An05g00840 Aspergillus niger uncharacterized protein XP_059600762.1 233283 D 5061 CDS An05g00850 4980824 join(234413..235241,235296..235551,235614..236253) VII 1 NT_166521.1 Similarity: theORF shows similarity to several multidrug-efflux transporter homologues from different species.; Title: strong similarity to multidrug resistance transporter fnx1p - Schizosaccharomyces pombe; See PMID 9710608; uncharacterized protein 236253 4980824 An05g00850 Aspergillus niger uncharacterized protein XP_001390662.1 234413 D 5061 CDS An05g00860 84591112 complement(236482..236841) VII 1 NT_166521.1 Remark: the ORF is questionable due to its short lenght of only 119 amino acids.; Title: questionable ORF; uncharacterized protein 236841 84591112 An05g00860 Aspergillus niger uncharacterized protein XP_059600763.1 236482 R 5061 CDS An05g00870 4980826 join(236876..237009,237107..237731,237782..239039,239102..239211,239343..239477) VII 1 NT_166521.1 Function: uaY of A. nidulans codes for a transcriptional activator mediating the induction of a number of unlinked genes involved in purine utilization by binding to the consensus sequence 5'-TCGGNNNNNNCCGA-3'.; Title: strong similarity to positive regulator of purine utilisation uaY - Aspergillus nidulans; nucleus; See PMID 9218768; uncharacterized protein 239477 4980826 An05g00870 Aspergillus niger uncharacterized protein XP_059600764.1 236876 D 5061 CDS An05g00880 4980827 complement(join(239676..240759,240832..240998)) VII 1 NT_166521.1 Remark: dnaJ protein homolog; Title: strong similarity to dnaJ protein homolog Scj1 - Saccharomyces cerevisiae; See PMID 8016869; uncharacterized protein 240998 4980827 An05g00880 Aspergillus niger uncharacterized protein XP_001390665.3 239676 R 5061 CDS An05g00890 84591113 join(241052..241132,241226..241549) VII 1 NT_166521.1 hypothetical protein 241549 84591113 An05g00890 Aspergillus niger hypothetical protein XP_059600765.1 241052 D 5061 CDS An05g00900 4980829 complement(join(241722..243532,243580..244015)) VII 1 NT_166521.1 Title: strong similarity to hypothetical protein SPAC32A11.02c - Schizosaccharomyces pombe; uncharacterized protein 244015 4980829 An05g00900 Aspergillus niger uncharacterized protein XP_059600766.1 241722 R 5061 CDS An05g00910 84591114 join(244731..244820,245086..245172,245744..245799,246019..246211) VII 1 NT_166521.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF; uncharacterized protein 246211 84591114 An05g00910 Aspergillus niger uncharacterized protein XP_059600767.1 244731 D 5061 CDS An05g00920 84591115 complement(join(247273..247697,247783..247794,247899..248024,248062..248146)) VII 1 NT_166521.1 hypothetical protein 248146 84591115 An05g00920 Aspergillus niger hypothetical protein XP_059600768.1 247273 R 5061 CDS An05g00930 4980832 join(248422..248492,248619..248725,248789..248901,248961..249039,249108..249456,249514..250585) VII 1 NT_166521.1 Catalytic activity: NADP-dependent malate dehydrogenases convert S)-malate + NADP(+) <=> pyruvate + CO(2) + NADPH.; Function: NADP-dependent malate dehydrogenases are involved in the metabolism of pyruvate by converting malate to pyruvat.; Title: strong similarity to NADP-dependent malate dehydrogenase mdh - Homo sapiens; uncharacterized protein 250585 4980832 An05g00930 Aspergillus niger uncharacterized protein XP_001390670.3 248422 D 5061 CDS An05g00940 84591116 complement(join(251176..251262,251312..251683)) VII 1 NT_166521.1 hypothetical protein 251683 84591116 An05g00940 Aspergillus niger hypothetical protein XP_059600769.1 251176 R 5061 CDS An05g00950 4980834 join(252147..252212,252267..252372,252429..252848,252940..253196,253248..253637) VII 1 NT_166521.1 Remark: nadA of A. parasiticus is part of a well-defined gene cluster (not yet identified in A. niger) related to sugar utilization in A. parasiticus and is located in proximity to an aflatoxin biosynthetic pathway gene cluster.; Similarity: the ORF shows similarity to different NADH-dependent oxidoreductases with various cellular function.; Title: strong similarity to NADH oxidase nadA -Aspergillus parasiticus; See PMID 10978525; uncharacterized protein 253637 4980834 An05g00950 Aspergillus niger uncharacterized protein XP_059600770.1 252147 D 5061 CDS An05g00960 4980835 join(254208..254600,254680..254853) VII 1 NT_166521.1 Function: imp3 of S. cerevisiae is involved in pre-rRNA processing, e. g. the pre-18S rRNA, by associating with the, Mpp10.; Remark: imp3 of S. cerevisiae is identical to YHR148w, which was originally believed to be a ribosomal protein.; Similarity: the ORF shows similarity to S4-like ribosomal proteins from different species, which have a similar S4 domain, that mediates RNA binding.; Title: strong similarity to U3 small nucleolar ribonucleoprotein Imp3 - Saccharomyces cerevisiae; nucleus; uncharacterized protein 254853 4980835 An05g00960 Aspergillus niger uncharacterized protein XP_001390673.1 254208 D 5061 CDS An05g00970 4980836 complement(255132..256283) VII 1 NT_166521.1 Similarity: the ORF shows unspecific similarity to serine-rich proteins.; hypothetical protein 256283 4980836 An05g00970 Aspergillus niger hypothetical protein XP_059600771.1 255132 R 5061 CDS An05g00980 4980837 join(257198..257299,257347..258318) VII 1 NT_166521.1 Function: uaY of A. nidulans codes for a transcriptional activator mediating the induction of a number of unlinked genes involved in purine utilization by binding to the consensus sequence 5'-TCGGNNNNNNCCGA-3'.; Similarity: the ORF is similar to 56WK on the same contig.; Similarity: the ORF shows similarity to transcriptional activators, which are probable involved in control of metabolism.; Similarity: the predicted ORF is 502 amino acids shorter at the N-terminus and 163 aa shorter at the C-terminus thanor UaY of E. nidulans.; Title: similarity to positive regulator of purine utilisation uaY - Aspergillus nidulans; nucleus; See PMID 9218768; uncharacterized protein 258318 4980837 An05g00980 Aspergillus niger uncharacterized protein XP_001390675.3 257198 D 5061 CDS An05g00990 4980838 join(258681..259718,259783..259803) VII 1 NT_166521.1 Catalytic activity: mdh of M. fervidus catalyses malate + NAD(+) <=> oxaloacetate + NADH (EC 1. 1. 1. 37) and malate + NADP(+) = oxaloacetat + NADPH (EC 1. 1. 1. 82).; Remark: mdh of M. fervidus has a low selectivity to the coenzyme NAD(H) or NADP(H), and catalyzes the reduction of oxaloacetate to malate more efficiently than the reverse reaction.; Remark: two isozymes of malate dehydrogenase exist,one which is located in the mitochondrial matrix and the other in the cytoplasm, additionally, fungi and plants also harbor a glyoxysomal form, which functions in the glyoxylate pathway.; Similarity: the ORF shows similarity to some NAD(+)-dependent malate dehydrogenases, especially from bacteria.; Title: strong similarity to malate dehydrogenase mdh - Methanothermus fervidus; See PMID 2110059; uncharacterized protein 259803 4980838 An05g00990 Aspergillus niger uncharacterized protein XP_001390676.3 258681 D 5061 CDS An05g01000 4980839 complement(259993..261480) VII 1 NT_166521.1 Similarity: the ORF shows weak similarity to SC6A11. 07c, a putative secreted nucleosidase of S. coelicolor.; Title: similarity to hypothetical protein CG12065 -Drosophila melanogaster; uncharacterized protein 261480 4980839 An05g01000 Aspergillus niger uncharacterized protein XP_001390677.1 259993 R 5061 CDS An05g01010 4980840 complement(join(262077..263265,263333..263981,264068..264088,264324..264330)) VII 1 NT_166521.1 Catalytic activity: plb1 of P. notatum catalyzes e. g. 2-lysophosphatidylcholine + H(2)O <=> glycerophosphocholine + a fatty acid anion.; Function: phospholipase B is involved in the release of fatty acids by hydrolyzing both the acyl ester bonds of diacylphospholipids (diacyl-hydrolase) and the acyl ester bond of monoacylphospholipids or lysophospholipids.; Function: plb1 of P. notatum has intrinsic lysophospholipase and phospholipase B activities.; Title: strong similarity to lysophospholipase plb1 -Penicillium notatum; extracellular/secretion proteins; See PMID 5402; See PMID 1722456; uncharacterized protein 264330 4980840 An05g01010 Aspergillus niger uncharacterized protein XP_059600772.1 262077 R 5061 CDS An05g01020 84591117 join(264511..264724,264875..264984) VII 1 NT_166521.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF; uncharacterized protein 264984 84591117 An05g01020 Aspergillus niger uncharacterized protein XP_059600773.1 264511 D 5061 CDS An05g01030 4980842 complement(join(265179..265448,265510..265700,265739..265961)) VII 1 NT_166521.1 Title: similarity to hypothetical protein encoded by An16g01380 - Aspergillus niger; uncharacterized protein 265961 4980842 An05g01030 Aspergillus niger uncharacterized protein XP_059600774.1 265179 R 5061 CDS An05g01040 4980843 join(266583..266642,266695..266950,267045..267208,267260..267397,267451..268206) VII 1 NT_166521.1 Similarity: the ORF shows similarity to the putative zinc-finger transcription regulator protein SPAC821. 07c of S. pombe.; Title: similarity to hypothetical protein CAD60719.1 - Podospora anserina; uncharacterized protein 268206 4980843 An05g01040 Aspergillus niger uncharacterized protein XP_001390681.3 266583 D 5061 CDS An05g01060 4980845 complement(join(269027..275998,276061..281299,281462..285519)) VII 1 NT_166521.1 Function: HTS1 of C. carbonum is a cyclic peptide synthetase, which catalyses the production of HC-toxin, a cyclic tetrapeptide.; Function: HTS1 of C. carbonum is able to activate L-proline, thiosterifies L-proline, and epimerizes it to D-proline; Induction: expression of HTS1 of C. carbonum is up regulated during spore germination.; Similarity: the ORF shows strong similarity to several peptide synthetase involved in synthesis of various toxins.; Title: strong similarity to HC-toxin synthase HTS1 -Cochliobolus carbonum; See PMID 1281482; See PMID 7655067; uncharacterized protein 285519 4980845 An05g01060 Aspergillus niger uncharacterized protein XP_059600775.1 269027 R 5061 CDS An05g01070 4980846 join(286162..286496,286551..287178) VII 1 NT_166521.1 Function: RTA1 of S. cerevisiae confers resistance to 7-aminocholesterol, a strong inhibitor of yeast and of Gram+-bacteria proliferation and probably improves the growth of heterologous microorganisms on media containing molasses.; Title: strong similarity to 7-aminocholesterol resistance protein Rta1 - Saccharomyces cerevisiae; See PMID 8660468; uncharacterized protein 287178 4980846 An05g01070 Aspergillus niger uncharacterized protein XP_001390683.1 286162 D 5061 CDS An05g01080 84591118 complement(join(288939..289681,289738..289957)) VII 1 NT_166521.1 Similarity: the ORF shows similarity to ankyrin-repeats containing proteins.; Similarity: the similarity of the ORF to AKT1 of A. thaliana is restricted to its C-terminal part, starting with amino acid 241 and concering a region, which is homologues to the ankyrin-repeat domain of AKT1 (aa 517 to 679).; Title: weak similarity to potassium channel protein AKT1 - Arabidopsis thaliana; uncharacterized protein 289957 84591118 An05g01080 Aspergillus niger uncharacterized protein XP_059600776.1 288939 R 5061 CDS An05g01090 84591119 join(290094..290188,290407..290459,290819..291003) VII 1 NT_166521.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght of only 110 amino acids.; Title: questionable ORF; uncharacterized protein 291003 84591119 An05g01090 Aspergillus niger uncharacterized protein XP_059600777.1 290094 D 5061 CDS An05g01100 4980849 complement(join(292800..293024,293124..293947,294044..294089)) VII 1 NT_166521.1 Function: TOXF is specifically required for HC-toxin production and pathogenicity.; Phenotype: a strain of C. carbonum with all copies of TOXF disrupted grew normally but lost HC-toxin production and pathogenicity.; Remark: the cyclic tetrapeptide HC-toxin is required for pathogenicity of the filamentous fungus Cochliobolus carbonum on maize.; Similarity: TOXF has moderate homology to many known or putative branched-chain-amino-acid transaminases from various species.; Title: strong similarity to HC-toxin biosynthesis protein TOXF - Cochliobolus carbonum; See PMID 10627051; uncharacterized protein 294089 4980849 An05g01100 Aspergillus niger uncharacterized protein XP_059600778.1 292800 R 5061 CDS An05g01110 4980850 join(294944..295162,295233..295764,295817..299913) VII 1 NT_166521.1 Function: YCF1 is required for cadmium resistance.; Phenotype: S. cerevisiae cells harboring a deletion of the YCF1 gene are hypersensitive to cadmium compared with wild type cells.; Remark: members of the ATP binding cassette (ABC) protein superfamily transport a variety of substances across biological membranes, including drugs, ions, and peptides.; Similarity: YCF1 shows extensive homology to both the human multidrug resistance-associated protein (MRP1) and the cystic fibrosis transmembrane conductance regulator (hCFTR).; Title: strong similarity to cadmium resistance protein Ycf1 - Saccharomyces cerevisiae; See PMID 7521334; uncharacterized protein 299913 4980850 An05g01110 Aspergillus niger uncharacterized protein XP_001390687.1 294944 D 5061 CDS An05g01120 4980851 complement(join(301328..302869,302940..302990)) VII 1 NT_166521.1 Catalytic activity: TRI11 catalyzes the hydroxylation at C-15 of isotrichodermin.; Pathway: TRI11 from F. sporotrichioides is involved trichothecene biosynthesis.; Remark: trichothecenes are sesquiterpenoid toxins that act by inhibiting protein biosynthesis.; Similarity: TRI11 belongs to the cytochrome p450 family.; Title: strong similarity to hypothetical cytochrome P450 monooxygenase TRI11 - Fusarium sporotrichioides; See PMID 9435078; uncharacterized protein 302990 4980851 An05g01120 Aspergillus niger uncharacterized protein XP_001390688.1 301328 R 5061 CDS An05g01140 84591120 complement(join(304588..305330,305367..305458,305709..305899)) VII 1 NT_166521.1 Title: weak similarity to hypothetical protein encoded by An14g07170 - Aspergillus niger; uncharacterized protein 305899 84591120 An05g01140 Aspergillus niger uncharacterized protein XP_059600779.1 304588 R 5061 CDS An05g01150 84591121 complement(join(307200..307591,307693..307995,308025..308049)) VII 1 NT_166521.1 hypothetical protein 308049 84591121 An05g01150 Aspergillus niger hypothetical protein XP_059600780.1 307200 R 5061 CDS An05g01160 4980855 join(308576..308830,308996..309335,309384..309553) VII 1 NT_166521.1 Similarity: the ORF shows similarity to methyltransferases.; Title: weak similarity to air bubble protein gvpA-gvpD-41 from patent CN1331110-A - Unclassified organism; uncharacterized protein 309553 4980855 An05g01160 Aspergillus niger uncharacterized protein XP_059600781.1 308576 D 5061 CDS An05g01170 4980856 join(310659..310937,310992..311390) VII 1 NT_166521.1 Function: ArsH from Th. ferrooxidans is not required for arsenic resistance in E. coli.; Title: strong similarity to arsenical resistance protein ArsH - Thiobacillus ferrooxidans; See PMID 10788346; uncharacterized protein 311390 4980856 An05g01170 Aspergillus niger uncharacterized protein XP_001390692.3 310659 D 5061 CDS An05g01180 4980857 complement(join(311519..311686,311774..311872,311981..312100)) VII 1 NT_166521.1 Title: strong similarity to hypothetical protein CAD71085.1 - Neurospora crassa; uncharacterized protein 312100 4980857 An05g01180 Aspergillus niger uncharacterized protein XP_059600782.1 311519 R 5061 CDS An05g01190 84591122 complement(join(312250..312371,312417..312432)) VII 1 NT_166521.1 Title: questionable ORF; uncharacterized protein 312432 84591122 An05g01190 Aspergillus niger uncharacterized protein XP_059600783.1 312250 R 5061 CDS An05g01200 4980859 join(312980..313160,313395..313600,313650..313919,313972..314104,314153..314203,314329..314537,314587..314685) VII 1 NT_166521.1 Catalytic activity: salicylate + NADH + O(2) = catechol + NAD(+) + H(2)O + CO(2).; Pathway: nahpthalene catabolism and phenylalanine metabolism.; Title: similarity to salicylate hydroxylase nahG -Pseudomonas putida; See PMID 1993181; uncharacterized protein 314685 4980859 An05g01200 Aspergillus niger uncharacterized protein XP_059600784.1 312980 D 5061 CDS An05g01210 4980860 complement(join(314941..314985,315036..315382,315452..315887)) VII 1 NT_166521.1 Function: biosynthesis of phosphatidic acid through the dihydroxyacetone phosphate pathway requires NADPH-dependent reduction of the intermediate 1-acyldihydroxyacetone phosphate by Ayr1p.; Localization: Ayr1p is a major component of lipid particles and is also found in the endoplasmic reticulum.; Pathway: Ayr1p is involved in phosphatidic acid biosynthesis.; Title: strong similarity to 1-acyldihydroxyacetone-phosphate reductase Ayr1 -Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 10617610; uncharacterized protein 315887 4980860 An05g01210 Aspergillus niger uncharacterized protein XP_001390696.1 314941 R 5061 CDS An05g01220 84591123 complement(join(316753..317402,317478..317556)) VII 1 NT_166521.1 Title: similarity to hypothetical protein encoded by An06g00680 - Aspergillus niger; uncharacterized protein 317556 84591123 An05g01220 Aspergillus niger uncharacterized protein XP_059600785.1 316753 R 5061 CDS An05g01230 84591124 complement(join(317913..317947,318072..318232,318389..318589,318668..319260)) VII 1 NT_166521.1 hypothetical protein 319260 84591124 An05g01230 Aspergillus niger hypothetical protein XP_059600786.1 317913 R 5061 CDS An05g01240 84591125 complement(join(319911..320269,320472..320655)) VII 1 NT_166521.1 hypothetical protein 320655 84591125 An05g01240 Aspergillus niger hypothetical protein XP_059600787.1 319911 R 5061 CDS An05g01250 84591126 complement(join(321293..321401,321431..322425)) VII 1 NT_166521.1 Title: weak similarity to protein fragment SEQ ID NO:23867 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 322425 84591126 An05g01250 Aspergillus niger uncharacterized protein XP_059600788.1 321293 R 5061 CDS An05g01260 84591127 complement(join(322982..323114,323202..324259)) VII 1 NT_166521.1 Title: similarity to hypothetical protein encoded by An05g01250 - Aspergillus niger; uncharacterized protein 324259 84591127 An05g01260 Aspergillus niger uncharacterized protein XP_059600789.1 322982 R 5061 CDS An05g01270 4980866 complement(join(325014..325177,325297..326272)) VII 1 NT_166521.1 Remark: antibodies against GOR are present in individuals with hepatitis C (non-A, non-B hepatitis).; Title: weak similarity to recombinant antigen GOR -Pan troglodytes; See PMID 1701012; uncharacterized protein 326272 4980866 An05g01270 Aspergillus niger uncharacterized protein XP_001390702.3 325014 R 5061 CDS An05g01280 84591128 complement(join(326885..327184,327221..327374,327743..327756)) VII 1 NT_166521.1 hypothetical protein 327756 84591128 An05g01280 Aspergillus niger hypothetical protein XP_059606057.1 326885 R 5061 CDS An05g01290 4980868 complement(join(328728..329381,329438..330412)) VII 1 NT_166521.1 Function: HXT3 can confer growth on medium containing at least 1% glucose.; Induction: HXT3 is maximally expressed after entry into stationary phase.; Title: strong similarity to hexose transporter Hxt3 - Saccharomyces cerevisiae; plasma membrane; See PMID 8417358; uncharacterized protein 330412 4980868 An05g01290 Aspergillus niger uncharacterized protein XP_001390704.1 328728 R 5061 CDS An05g01300 84591129 join(330813..330932,331050..331123,331274..331387,331478..331690,331767..332157) VII 1 NT_166521.1 Title: weak similarity to site specific integrase from patent WO9419460-A - bacteriophage phi LC3; uncharacterized protein 332157 84591129 An05g01300 Aspergillus niger uncharacterized protein XP_059606058.1 330813 D 5061 CDS An05g01310 84591130 complement(join(334057..334184,334216..334279)) VII 1 NT_166521.1 hypothetical protein 334279 84591130 An05g01310 Aspergillus niger hypothetical protein XP_059606059.1 334057 R 5061 CDS An05g01320 4980871 join(335134..335857,335921..336049,336110..336408) VII 1 NT_166521.1 Function: man1 plays a role in fructose and mannose metabolism.; Title: strong similarity to mannase man1 -Aspergillus aculeatus; See PMID 7987261; uncharacterized protein 336408 4980871 An05g01320 Aspergillus niger uncharacterized protein XP_001390707.1 335134 D 5061 CDS An05g01330 4980872 complement(join(336697..337218,337285..337845)) VII 1 NT_166521.1 Title: weak similarity to hypothetical protein CC0892 - Caulobacter crescentus; uncharacterized protein 337845 4980872 An05g01330 Aspergillus niger uncharacterized protein XP_059606060.1 336697 R 5061 CDS An05g01340 4980873 338485..340137 VII 1 NT_166521.1 Title: weak similarity to regulator protein Arg81 -Saccharomyces cerevisiae; uncharacterized protein 340137 4980873 An05g01340 Aspergillus niger uncharacterized protein XP_001390709.1 338485 D 5061 CDS An05g01350 4980874 join(340513..341255,341308..341824) VII 1 NT_166521.1 hypothetical protein 341824 4980874 An05g01350 Aspergillus niger hypothetical protein XP_001390710.1 340513 D 5061 CDS An05g01360 4980875 complement(join(343107..344040,344123..344319,344394..344441)) VII 1 NT_166521.1 Title: weak similarity to zinc binuclear cluster protein sequence #105 from patent WO200224865-A2 -Unclassified organism; uncharacterized protein 344441 4980875 An05g01360 Aspergillus niger uncharacterized protein XP_059606061.1 343107 R 5061 CDS An05g01370 4980876 complement(join(344797..344905,344968..345275)) VII 1 NT_166521.1 hypothetical protein 345275 4980876 An05g01370 Aspergillus niger hypothetical protein XP_059606062.1 344797 R 5061 CDS An05g01380 4980877 complement(join(345538..345558,345688..346491)) VII 1 NT_166521.1 Function: linX is involved in the degradation of gamma-hexachlorocyclohexane in Pseudomonas paucimobilis.; Similarity: linX show homology to members of the short-chain alcohol dehydrogenase family.; Title: strong similarity to 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase linX - Sphingomonas paucimobilis; See PMID 7515041; uncharacterized protein 346491 4980877 An05g01380 Aspergillus niger uncharacterized protein XP_001390713.3 345538 R 5061 CDS An05g01390 84591131 complement(join(346627..346712,346797..346964,347008..347113,347235..347255)) VII 1 NT_166521.1 hypothetical protein 347255 84591131 An05g01390 Aspergillus niger hypothetical protein XP_059606063.1 346627 R 5061 CDS An05g01400 4980879 347295..347789 VII 1 NT_166521.1 Title: strong similarity to hypothetical protein encoded by An08g03760 - Aspergillus niger; uncharacterized protein 347789 4980879 An05g01400 Aspergillus niger uncharacterized protein XP_001390715.1 347295 D 5061 CDS An05g01410 4980880 complement(join(348510..349036,349096..349150,349205..349727,349782..349931,349986..350105,350157..350355,350400..350541)) VII 1 NT_166521.1 Catalytic activity: ACX2 of A. thaliana is active with long-chain acyl-CoAs; maximal activity with C18-CoA.; Localization: ACX2 of A. thaliana contains a peroxisomal targeting signal and, according to other known homologues, probably is located in the peroxisome.; Pathway: fatty acid beta-oxidation.; Title: similarity to acyl-CoA oxidase ACX2 -Arabidopsis thaliana; See PMID 10571860; uncharacterized protein 350541 4980880 An05g01410 Aspergillus niger uncharacterized protein XP_001390716.1 348510 R 5061 CDS An05g01420 84591132 join(351415..351431,351496..351769,351921..351961,352138..352209,352411..352524,352640..352700) VII 1 NT_166521.1 Title: weak similarity to hypothetical protein encoded by An08g08120 - Aspergillus niger; uncharacterized protein 352700 84591132 An05g01420 Aspergillus niger uncharacterized protein XP_059606064.1 351415 D 5061 CDS An05g01430 84591133 join(353015..353027,353078..353277,353350..353603,353642..353822) VII 1 NT_166521.1 Function: motA of E. coli is required for flagellar rotation.; Title: weak similarity to chemotaxis protein motA -Escherichia coli; See PMID 6090403; uncharacterized protein 353822 84591133 An05g01430 Aspergillus niger uncharacterized protein XP_059606065.1 353015 D 5061 CDS An05g01440 4980883 complement(join(354441..355231,355279..355739,355789..355919,355954..356109)) VII 1 NT_166521.1 Function: in A. niger GABA is used as a nitrogen source.; Induction: transcription of the gabA gene of A. nidulans is activated by the transcriptionfactor IntA.; Repression: transcription of the gabA gene of A. nidulans is repressed by the zinc finger transcription factor PacC.; Title: strong similarity to GABA permease gabA -Aspergillus nidulans; plasma membrane; See PMID 10320578; uncharacterized protein 356109 4980883 An05g01440 Aspergillus niger uncharacterized protein XP_059606066.1 354441 R 5061 CDS An05g01450 4980884 complement(join(357302..357355,357429..358448)) VII 1 NT_166521.1 Catalytic activity: 2-nitropropane dioxygenase of N. crassa catalyzes the oxidation of nitroalkanes to produce the corresponding carbonyl compounds; the preferred substrate is 2-nitropropane; the reaction stoichiometry is 2CH3CH(NO2)CH3 + O2 --> 2CH3COCH3 + 2HNO2.; Catalytic activity: nitroethane and 1-nitropropane can act as donors, more slowly.; Complex: the Neurospora enzyme contains flavin mononucleotide as a prosthetic group.; Title: strong similarity to 2-nitropropane dioxygenase ncd-2 - Neurospora crassa; See PMID 9501443; uncharacterized protein 358448 4980884 An05g01450 Aspergillus niger uncharacterized protein XP_059606067.1 357302 R 5061 CDS An05g01460 84591134 complement(join(358811..358945,359119..359230,359425..359585)) VII 1 NT_166521.1 hypothetical protein 359585 84591134 An05g01460 Aspergillus niger hypothetical protein XP_059606068.1 358811 R 5061 CDS An05g01470 84591135 join(359735..359902,359952..360758) VII 1 NT_166521.1 Similarity: a local weak similarity to a putative malate oxidoreductase of A. thaliana cannot be considered significant due to length difference and absence of any structural domain compatible with oxydoreductase activity in the predicted ORF.; Title: similarity to hypothetical protein encoded by An13g01730 - Aspergillus niger; uncharacterized protein 360758 84591135 An05g01470 Aspergillus niger uncharacterized protein XP_059606069.1 359735 D 5061 CDS An05g01480 84591136 join(361155..362259,362299..362478,362598..362611) VII 1 NT_166521.1 Similarity: the predicted ORF shows similarity also to bem46 of S. pombe, annotated as supressor of bem1/bud5,but without published characterization.; Title: similarity to Kidney injury associated molecule HW073 from patent WO9853071-A1 - Rattus sp.; uncharacterized protein 362611 84591136 An05g01480 Aspergillus niger uncharacterized protein XP_059606070.1 361155 D 5061 CDS An05g01490 4980888 complement(join(362689..362743,362797..363074)) VII 1 NT_166521.1 Title: strong similarity to hypothetical protein PA3762 - Pseudomonas aeruginosa; uncharacterized protein 363074 4980888 An05g01490 Aspergillus niger uncharacterized protein XP_001390724.1 362689 R 5061 CDS An05g01500 4980889 complement(join(363519..363593,363647..364175,364230..365011,365071..365178)) VII 1 NT_166521.1 Function: CYHR of C. maltosa confers resistance to cycloheximide.; Function: multidrug transporters are membrane proteins which, by an unknown mechanism, recognize diverse toxic compounds and efflux them from cells.; Localization: CYHR of C. maltosa is an integral membrane protein.; Remark: the predicted protein also shows strong similarity to a protein involved in cephalosporin C biosynthesis of Acremonium chrysogenum (Patent JP09009966-A), which is only poorly described.; Similarity: CYHR of C. maltosa belongs to the car1/cyhr subfamily.; Similarity: CYHR of C. maltosa belongs to the multidrudrug resistance family.; Title: strong similarity to cyclohexamide resistance protein CYHR - Candida maltosa; plasma membrane; See PMID 1628836; uncharacterized protein 365178 4980889 An05g01500 Aspergillus niger uncharacterized protein XP_001390725.3 363519 R 5061 CDS An05g01510 84591137 complement(365627..365773) VII 1 NT_166521.1 Title: questionable ORF; uncharacterized protein 365773 84591137 An05g01510 Aspergillus niger uncharacterized protein XP_059606071.1 365627 R 5061 CDS An05g01520 4980891 complement(366246..366866) VII 1 NT_166521.1 Title: similarity to hypothetical conserved protein aq_1250 - Aquifex aeolicus; uncharacterized protein 366866 4980891 An05g01520 Aspergillus niger uncharacterized protein XP_001390727.1 366246 R 5061 CDS An05g01530 84591138 join(367221..367335,367433..367497) VII 1 NT_166521.1 Title: questionable ORF; uncharacterized protein 367497 84591138 An05g01530 Aspergillus niger uncharacterized protein XP_059606072.1 367221 D 5061 CDS An05g01550 84591139 join(367953..367970,368022..368238,368342..368456,368724..368757) VII 1 NT_166521.1 Remark: the ORF has an unusual exon/intron structure for A. niger.; hypothetical protein 368757 84591139 An05g01550 Aspergillus niger hypothetical protein XP_059606073.1 367953 D 5061 CDS An05g01560 4980895 369157..370062 VII 1 NT_166521.1 Function: 2,3-Dihydro-2,3-dihydroxybiphenyl-2,3-dehydrogenase (B2,3D) catalyzes the second step in the biphenyl degradation pathway in C. testosteroni.; Similarity: SDR is a very large family of enzymes,most of which are known to be NAD- or NADP-dependent oxidoreductases with different specificities.; Similarity: the predicted ORF shows strong similarity to several hypothetical and described members of the short chain dehydrogenase (SDR) protein family.; Title: similarity to 2,3-dihydro-2,3-dihydroxybiphenyl-2,3-dehydrogenase bphB - Comamonas testosteroni; See PMID 8702262; uncharacterized protein 370062 4980895 An05g01560 Aspergillus niger uncharacterized protein XP_001390730.1 369157 D 5061 CDS An05g01580 84591140 join(370802..370856,370933..371083,371182..371482) VII 1 NT_166521.1 Title: weak similarity to hypothetical sensor protein XF2535 - Xylella fastidiosa; uncharacterized protein 371482 84591140 An05g01580 Aspergillus niger uncharacterized protein XP_059606074.1 370802 D 5061 CDS An05g01590 84591141 join(372088..372090,372223..372550,372780..372973,373049..373303) VII 1 NT_166521.1 Similarity: weak local similarity to proteins with completely different length.; hypothetical protein 373303 84591141 An05g01590 Aspergillus niger hypothetical protein XP_059606075.1 372088 D 5061 CDS An05g01600 4980899 complement(join(374167..375522,375580..375630,375722..375877,375961..376348,376438..376538)) VII 1 NT_166521.1 Similarity: the N-terminal region of the predicted ORF contains a fungal Zn(2)-Cys(6) binuclear cluster domain, a cysteine-rich region that binds DNA, and is found in many fungal transcriptional activators.; Similarity: the predicted ORF shows similarity to several putative transcription factors.; Title: similarity to transcription activator Cha4 -Saccharomyces cerevisiae; See PMID 8889513; See PMID 8967907; uncharacterized protein 376538 4980899 An05g01600 Aspergillus niger uncharacterized protein XP_059606076.1 374167 R 5061 CDS An05g01610 4980900 join(377000..377301,377364..377638,377705..378075,378131..378885,378946..379684) VII 1 NT_166521.1 Function: zeaxanthin epoxidase of N. plumbaginifolia is involved in the biosynthesis of the plant hormone abscisic acid.; Remark: closest manual BLASTP homologue: PIR:S69548.; Similarity: the C-terminal part of the predicted protein shows no similarity.; Similarity: the predicted ORF shows strong similarity to many hypothetical and known monooxygenases.; Title: similarity to zeaxanthin epoxidase precursor ABA2 - Nicotiana plumbaginifolia; See PMID 8665840; See PMID 1444267; uncharacterized protein 379684 4980900 An05g01610 Aspergillus niger uncharacterized protein XP_001390734.1 377000 D 5061 CDS An05g01620 10098144 complement(join(<381733..383544,383630..>384623)) VII 1 NT_166521.1 Function: the homolog Podospora anserina het-e gene is involved in vegetative incompatibility. co-expression of antagonistic alleles of het-e and het-c triggers a cell death reaction that prevents the formation of viable heterokaryons between strains that contain incompatible combinations of het-c and het-e alleles.; Title: strong similarity to beta transducin-like protein het-e1 - Podospora anserina; uncharacterized protein 384623 10098144 An05g01620 Aspergillus niger uncharacterized protein XP_003188687.2 381733 R 5061 CDS An05g01640 4980903 complement(385631..386800) VII 1 NT_166521.1 Title: strong similarity to hypothetical protein sll1376 - Synechocystis sp.; uncharacterized protein 386800 4980903 An05g01640 Aspergillus niger uncharacterized protein XP_001390736.1 385631 R 5061 CDS An05g01650 4980904 complement(join(388598..388741,388796..389296,389360..389540,389602..389920,389997..390030)) VII 1 NT_166521.1 Function: the A. terreus homolog LovD encodes a transesterase enzyme that catalyzes attachment of the 2-methylbutyric acid to monacolin J in the final step of the synthesis of lovastatin, an HMG-CoA reductase inhibitor.; Title: strong similarity to transesterase lovD from patent WO200037629-A2 - Aspergillus terreus; See PMID 10334994; uncharacterized protein 390030 4980904 An05g01650 Aspergillus niger uncharacterized protein XP_059606077.1 388598 R 5061 CDS An05g01660 4980905 complement(join(391434..395233,395301..395988)) VII 1 NT_166521.1 Function: the S. cerevisiae homolog gene PDR5 encodes a membrane protein of the ATP-binding-cassette (ABC) superfamily, which is functioning as a drug extrusion pump with multiple pleiotropic substrates.; Induction: expression of S. cerevisiae Pdr5p is regulated by the pleiotropic drug resistance (PDR) network. transcriptional regulator are Pdr1p, Pdr3p, Pdr7p, and Pdr9p, which also control transcription of several other target genes, many of them also ABC transporter proteins like SNQ2, STE6, PDR10, PDR11 and YOR1.; Title: strong similarity to pleiotropic drug resistance protein Pdr5 - Saccharomyces cerevisiae; plasma membrane; uncharacterized protein 395988 4980905 An05g01660 Aspergillus niger uncharacterized protein XP_001390738.1 391434 R 5061 CDS An05g01670 84591142 complement(join(396262..396365,396547..396922,397005..397108,397152..397325,397425..397498,397566..397669)) VII 1 NT_166521.1 hypothetical protein 397669 84591142 An05g01670 Aspergillus niger hypothetical protein XP_059606078.1 396262 R 5061 CDS An05g01680 4980907 join(398024..398381,398436..398914,398968..399143,399199..399771,399826..400051) VII 1 NT_166521.1 Title: similarity to hypothetical transcription regulator SPAC11D3.07c - Schizosaccharomyces pombe; uncharacterized protein 400051 4980907 An05g01680 Aspergillus niger uncharacterized protein XP_001390740.3 398024 D 5061 CDS An05g01700 4980909 complement(join(401256..401305,401409..401553,401719..402262,402313..402393,402444..403062,403110..403297,403344..403836,403890..404052,404099..404835,404889..405122,405168..405447,405500..406239,406308..406521)) VII 1 NT_166521.1 Function: the homolog yeast cadmium factor Ycf1p is a vacuolar ATP binding cassette (ABC) transporter required for heavy metal and drug detoxification.; Similarity: S. cerevisiae Ycf1p is strongly related to the human multidrug-associated protein (MRP1) and cystic fibrosis transmembrane conductance regulator (CFTR).; Title: strong similarity to cadmium resistance protein Ycf1 - Saccharomyces cerevisiae; vacuole; uncharacterized protein 406521 4980909 An05g01700 Aspergillus niger uncharacterized protein XP_059606079.1 401256 R 5061 CDS An05g01710 4980910 complement(join(407146..407421,407480..407962)) VII 1 NT_166521.1 Title: weak similarity to hypothetical protein CAD21295.1 - Neurospora crassa; uncharacterized protein 407962 4980910 An05g01710 Aspergillus niger uncharacterized protein XP_001390742.1 407146 R 5061 CDS An05g01720 4980911 complement(join(408479..409155,409206..409491)) VII 1 NT_166521.1 Title: similarity to hypothetical protein CAD21295.1 - Neurospora crassa; uncharacterized protein 409491 4980911 An05g01720 Aspergillus niger uncharacterized protein XP_001390743.1 408479 R 5061 CDS An05g01730 4980912 join(409957..410035,410099..410334) VII 1 NT_166521.1 hypothetical protein 410334 4980912 An05g01730 Aspergillus niger hypothetical protein XP_001390744.1 409957 D 5061 CDS An05g01740 4980913 complement(join(410392..410526,410605..410728,410779..410890,410941..412117,412190..412375)) VII 1 NT_166521.1 Function: the S. cerevisiae homolog Put4p is a high affinity proline permease, that also transports alanine and glycine.; Localization: S. cerevisiae Put4p is predominantly localized in an internal storage compartment. under nitrogen limited growth conditions, Put4p sorting is redirected to the cell surface.; Title: strong similarity to proline transporter Put4 - Saccharomyces cerevisiae; plasma membrane; uncharacterized protein 412375 4980913 An05g01740 Aspergillus niger uncharacterized protein XP_001390745.3 410392 R 5061 CDS An05g01750 4980914 complement(413342..414568) VII 1 NT_166521.1 Complex: S. cerevisiae Hoc1p is a subunit of the Anp1p-Hoc1p-Mnn11p-Mnn9p mannosyltransferase complex.; Function: the S. cerevisiae homolog Hoc1p is a Golgi localized mannosyltransferase involved in cell wall integrity.; Golgi; Title: strong similarity to alpha-1,6-mannosyltransferase Hoc1 - Saccharomyces cerevisiae; uncharacterized protein 414568 4980914 An05g01750 Aspergillus niger uncharacterized protein XP_001390746.3 413342 R 5061 CDS An05g01760 4980915 join(414969..414990,415124..416607) VII 1 NT_166521.1 Function: the C. gloeosporioides homolog CHIP3 is potentially involved in differentiation into the infection structure appressorium.; Induction: C. gloeosporioides CHIP3 is induced by a 2-h hard-surface contact.; Title: similarity to hard surface induced protein 3 chip3 - Glomerella cingulata; uncharacterized protein 416607 4980915 An05g01760 Aspergillus niger uncharacterized protein XP_059606080.1 414969 D 5061 CDS An05g01770 4980916 417143..418459 VII 1 NT_166521.1 hypothetical protein 418459 4980916 An05g01770 Aspergillus niger hypothetical protein XP_001390748.1 417143 D 5061 CDS An05g01780 4980917 join(421355..421883,421950..422032,422090..422778,422849..423314,423404..423454) VII 1 NT_166521.1 Title: similarity to hypothetical protein SA1981 -Staphylococcus aureus; uncharacterized protein 423454 4980917 An05g01780 Aspergillus niger uncharacterized protein XP_059606081.1 421355 D 5061 CDS An05g01790 84591143 join(423812..423818,423881..423933) VII 1 NT_166521.1 hypothetical protein 423933 84591143 An05g01790 Aspergillus niger hypothetical protein XP_059606082.1 423812 D 5061 CDS An05g01800 4980919 join(424929..425151,425289..426832) VII 1 NT_166521.1 hypothetical protein 426832 4980919 An05g01800 Aspergillus niger hypothetical protein XP_059606083.1 424929 D 5061 CDS An05g01810 4980920 complement(427122..428189) VII 1 NT_166521.1 Catalytic activity: 2 2-nitropropane + O(2) <=> 2 acetone + 2 nitrite.; Function: the N. crassa homolog ncd-2 is a 2-nitropropane dioxygenase that catalyzes the oxidation of nitroalkanes to produce the corresponding carbonyl compounds.; Remark: the homolog N. crassa ncd-2 contains flavin mononucleotide as a prosthetic group.; Title: strong similarity to 2-nitropropane dioxygenase precursor ncd-2 - Neurospora crassa; uncharacterized protein 428189 4980920 An05g01810 Aspergillus niger uncharacterized protein XP_001390752.1 427122 R 5061 CDS An05g01820 4980921 complement(428614..429015) VII 1 NT_166521.1 Title: strong similarity to hypothetical protein yphH - Lactococcus lactis; uncharacterized protein 429015 4980921 An05g01820 Aspergillus niger uncharacterized protein XP_001390753.1 428614 R 5061 CDS An05g01830 4980922 complement(429604..431244) VII 1 NT_166521.1 Title: strong similarity to transcription repressor Rdr1 - Saccharomyces cerevisiae; uncharacterized protein 431244 4980922 An05g01830 Aspergillus niger uncharacterized protein XP_001390754.1 429604 R 5061 CDS An05g01840 4980923 complement(join(431964..432174,432227..432358,432412..433398,433456..433604,433673..433726)) VII 1 NT_166521.1 Function: the S. cerevisiae homolog Tpo1p is a polyamine transport protein on the vacuolar membrane. Tpo1p regulates cytoplasmic concentration of polyamines and therefore mediates cell resistance by transport into the vacolar lumen.; Title: strong similarity to vacuolar polyamine transporter Tpo1p from patent WO200107592-A2 -Saccharomyces cerevisiae; vacuole; uncharacterized protein 433726 4980923 An05g01840 Aspergillus niger uncharacterized protein XP_001390755.1 431964 R 5061 CDS An05g01850 4980924 join(434526..434647,434709..436008) VII 1 NT_166521.1 Function: monocarboxylate transporter are involved in the transport of e. g. lactate and pyruvate.; Title: similarity to monocarboxylate transporter MCT2 - Homo sapiens; uncharacterized protein 436008 4980924 An05g01850 Aspergillus niger uncharacterized protein XP_001390756.1 434526 D 5061 CDS An05g01860 4980925 join(436693..438103,438156..438655) VII 1 NT_166521.1 Remark: the S. cerevisiae homolog orf Z37509 is located in the 3' non-coding region of MEL3-MEL10 genes and is most likely not expressed efficiently if at all.; Similarity: the ORF shows similarity to the superfamily of amidases.; Title: strong similarity to hypothetical amidase Z37509 - Saccharomyces cerevisiae; uncharacterized protein 438655 4980925 An05g01860 Aspergillus niger uncharacterized protein XP_001390757.1 436693 D 5061 CDS An05g01870 4980926 join(439090..439659,439706..440066,440132..440604,440674..440748) VII 1 NT_166521.1 Function: the C. albicans homolog CPY encodes the vacuolar serine proteinase carboxypeptidase y. carboxypeptdiase y is synthesized as a precursor form that is processed in the vacuolar lumen. CPY exhibits the major vacuolar proteolytic activity.; Title: strong similarity to carboxypeptidase y CPY -Candida albicans; vacuole; uncharacterized protein 440748 4980926 An05g01870 Aspergillus niger uncharacterized protein XP_001390758.1 439090 D 5061 CDS An05g01880 4980927 join(442254..442373,442433..442563,442621..442643,442694..442860,442992..443214,443289..443422,443479..443565) VII 1 NT_166521.1 Similarity: the ORF shows strong similarity to expressed sequence tag an_0938 from Aspergillus niger.; Title: strong similarity to hypothetical chloroperoxidase cpo - Agaricus bisporus; uncharacterized protein 443565 4980927 An05g01880 Aspergillus niger uncharacterized protein XP_001390759.1 442254 D 5061 CDS An05g01890 4980928 complement(join(443884..444789,444823..444974,445009..445141,445211..445405)) VII 1 NT_166521.1 Similarity: the ORF shows similarity to mRNA sequence of cDNA clone 3067 of A. niger. The ORF sequence deviates in several positions from the sequence of the genomic DNA.; Title: strong similarity to hypothetical protein related to host-specific AK-toxin Akt2 B23L21.350 -Neurospora crassa; uncharacterized protein 445405 4980928 An05g01890 Aspergillus niger uncharacterized protein XP_059606084.1 443884 R 5061 CDS An05g01900 84591144 complement(join(446359..446603,446679..446966,447017..447294,447451..447638,447779..447820)) VII 1 NT_166521.1 Remark: similarity is exclusively due to DSD repeats.; Title: weak similarity to fibrinogen-binding protein clfA - Staphylococcus aureus; uncharacterized protein 447820 84591144 An05g01900 Aspergillus niger uncharacterized protein XP_059606085.1 446359 R 5061 CDS An05g01910 84591145 complement(join(448320..448813,448880..449570,449637..449684)) VII 1 NT_166521.1 Title: strong similarity to hypothetical protein encoded by An05g01900 - Aspergillus niger; uncharacterized protein 449684 84591145 An05g01910 Aspergillus niger uncharacterized protein XP_059606086.1 448320 R 5061 CDS An05g01920 84591146 join(449792..449808,449851..450003,450187..450275,450329..450372,450464..450585,450679..450747,450932..451119,451293..451429) VII 1 NT_166521.1 hypothetical protein 451429 84591146 An05g01920 Aspergillus niger hypothetical protein XP_059606087.1 449792 D 5061 CDS An05g01930 84591147 complement(join(451492..451836,451886..451936)) VII 1 NT_166521.1 hypothetical protein 451936 84591147 An05g01930 Aspergillus niger hypothetical protein XP_059606088.1 451492 R 5061 CDS An05g01940 84591148 join(451991..452107,452179..452248,452304..452722) VII 1 NT_166521.1 Title: similarity to hypothetical protein CAG74385.1 - Erwinia carotovora; uncharacterized protein 452722 84591148 An05g01940 Aspergillus niger uncharacterized protein XP_059606089.1 451991 D 5061 CDS An05g01960 4980935 complement(join(453666..453923,453987..454655)) VII 1 NT_166521.1 Title: similarity to hypothetical protein BAB49283.1 - Mesorhizobium loti; uncharacterized protein 454655 4980935 An05g01960 Aspergillus niger uncharacterized protein XP_001390766.1 453666 R 5061 CDS An05g01980 10098146 complement(457291..>460257) VII 1 NT_166521.1 Function: Tto1 can transpose autonomously through reverse transcription.; Remark: Tto1 is one of the few active retrotransposons of plants.; Remark: a putative point mutation results in a premature STOP-codon.; Title: similarity to retrotransposon Tto1 -Nicotiana tabacum [putative sequencing error]; putative sequencing error; See PMID 8624443; uncharacterized protein 460257 10098146 An05g01980 Aspergillus niger uncharacterized protein XP_059606090.1 457291 R 5061 CDS An05g02000 4980937 complement(join(461140..461169,461316..461338,461683..462436,462486..462554,462606..462695)) VII 1 NT_166521.1 Catalytic activity: L-Threonine + NAD+ = L-2-Amino-3-oxobutanoate + NADH.; Pathway: Glycine, serine and threonine metabolism.; Remark: contains Pfam alcohol dehydrogenase zinc domain from aa residue 13 to 320.; Similarity: similarity to various pro- and eukaryotic dehydrogenases (EC 1. 1. 1. -) generally involved in carbohydrate metabolism.; Title: strong similarity to L-threonine 3-dehydrogenase tdh - Escherichia coli; uncharacterized protein 462695 4980937 An05g02000 Aspergillus niger uncharacterized protein XP_059603722.1 461140 R 5061 CDS An05g02010 4980938 complement(join(463630..464027,464088..464668,464713..464950,464989..465283,465333..465470)) VII 1 NT_166521.1 Function: the SUT1 protein from P. stipitis mediates glucose uptake.; Localization: integral membrane protein (by similarity).; Similarity: belongs to the sugar transporter family.; Title: strong similarity to sugar transporter Sut1 -Pichia stipitis; plasma membrane; uncharacterized protein 465470 4980938 An05g02010 Aspergillus niger uncharacterized protein XP_059603723.1 463630 R 5061 CDS An05g02020 4980939 join(465853..465929,465986..466682,466874..467531,467622..467818) VII 1 NT_166521.1 Similarity: contains Pfam Zn(2)-Cys(6) binuclear cluster domain from aa 24 to 62.; Similarity: similarities correspond to multiple cysteine and arginine repeats.; Title: weak similarity to negative acting factor naf - Fusarium solani; See PMID 7744822; See PMID 9139694; uncharacterized protein 467818 4980939 An05g02020 Aspergillus niger uncharacterized protein XP_059603724.1 465853 D 5061 CDS An05g02030 4980940 complement(join(468369..468675,468731..469428)) VII 1 NT_166521.1 Catalytic activity: A 1,4-lactone + H(2)O <=> a 4-hydroxyacid.; Function: lactonohydrolases catalyse the hydrolysis of lactone compounds to hydroxy acids.; Title: strong similarity to lactonohydrolase from patent WO200028043-A2 - Fusarium venenatum; uncharacterized protein 469428 4980940 An05g02030 Aspergillus niger uncharacterized protein XP_001390771.1 468369 R 5061 CDS An05g02040 4980941 join(469671..469721,469909..470306,470370..470640) VII 1 NT_166521.1 Catalytic activity: d-fructose 1,6-bisphosphate = glycerone-phosphate + d-glyceraldehyde 3-phosphate.; Cofactor: zinc (by similarity).; Pathway: sixth step in glycolysis.; Similarity: no similatity in N-terminus.; Similarity: the S. aureus Alf1 gene product belongs to class II fructose-bisphosphate aldolase family.; Title: strong similarity to fructose-bisphosphate aldolase Alf1 from patent WO200012678-A2 - Staphylococcus aureus; uncharacterized protein 470640 4980941 An05g02040 Aspergillus niger uncharacterized protein XP_059603725.1 469671 D 5061 CDS An05g02050 4980942 complement(join(470885..471347,471402..471748)) VII 1 NT_166521.1 Catalytic activity: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP + = 3-oxoacyl-[acyl-carrier protein] + NADPH.; Pathway: fatty acid biosynthesis.; Title: strong similarity to 3-oxoacyl-(acyl-carrier-protein) reductase srb - Bacillus subtilis; uncharacterized protein 471748 4980942 An05g02050 Aspergillus niger uncharacterized protein XP_001390773.1 470885 R 5061 CDS An05g02060 4980943 join(472038..472119,472170..472591,472643..472943,473143..473189) VII 1 NT_166521.1 Catalytic activity: R-CHOH-R' + NADP(+) <=> R-CO-R' + NADPH.; Function: catalyzes the reduction of ethyl 4-chloro-3-oxobutanoate (COBE) to ethyl (S)-4-chloro-3-hydroxybutanoate (CHBE), with a 100% enantiomeric excess.; Similarity: the C. magnoliae carbonyl reductase is also patented (patent WO9835025-A1) for its use to provide for sufficient production of optically active 3-hydroxybutanoate esters for use as synthetic intermediates for pharmaceuticals.; Title: strong similarity to carbonyl reductase (NADPH) S1 - Candida magnoliae; See PMID 10945260; uncharacterized protein 473189 4980943 An05g02060 Aspergillus niger uncharacterized protein XP_059603726.1 472038 D 5061 CDS An05g02070 4980944 complement(join(<473452..473913,473971..474583)) VII 1 NT_166521.1 Catalytic activity: alcohol + NADP(+) = aldehyde + NADPH.; Function: the R. norvegicus ALR protein catalyzes the NADPH-dependent reduction of 3-deoxyglucosone (3-dg).; Similarity: belongs to the aldo/keto reductase family.; Title: strong similarity to aldehydereductase ALR -Rattus norvegicus [putative frameshift]; putative frameshift; See PMID 8500767; uncharacterized protein 474583 4980944 An05g02070 Aspergillus niger uncharacterized protein XP_059603727.1 473452 R 5061 CDS An05g02080 4980945 complement(join(475422..475893,475957..476074,476307..476505,476562..476780)) VII 1 NT_166521.1 hypothetical protein 476780 4980945 An05g02080 Aspergillus niger hypothetical protein XP_059603728.1 475422 R 5061 CDS An05g02090 84591149 complement(477484..478458) VII 1 NT_166521.1 Similarity: similarity is restricted to the central region of retrotransposable element tf2 of S. pombe,containing a Pfam-domain of Reverse transcriptase .; Similarity: the retrotransposable element tf2 of S. pombe has regional similarity to protease, reverse transcriptase, RNAse H and integrase from other retrotransposons and retroviruses.; Title: similarity to retrotransposable element tf2 155 kd protein - Schizosaccharomyces pombe; See PMID 8396547; uncharacterized protein 478458 84591149 An05g02090 Aspergillus niger uncharacterized protein XP_059603729.1 477484 R 5061 CDS An05g02100 4980947 join(479879..480043,480099..480137,480223..480338,480408..480516,480585..480813,480872..481034,481100..481246,481312..481552,481632..481919) VII 1 NT_166521.1 Catalytic activity: endohydrolysis of 1,4-alpha-D-glucosidic linkages in polysaccharides containing three or more 1,4-alpha-linked D-glucose units.; Gene-ID: amyA;amyB; Pathway: glycogen/starch degradation.; Remark: a nearly identical match (even on DNA level) was found to ORF An12g06930.; Similarity: the nucleotide sequences of amyA and amyB from A. niger are identical throughout all but the last few nucleotides of their respective coding regions.; See PMID 2340591; extracellular alpha-amylase amyA/amyB-Aspergillus niger 481919 amyA 4980947 amyA Aspergillus niger extracellular alpha-amylase amyA/amyB-Aspergillus niger XP_001390778.3 479879 D 5061 CDS An05g02110 4980948 join(482156..482278,482546..484033) VII 1 NT_166521.1 Similarity: the ORF shows similarity to plasmid NA2 DNA encoding neutral alpha-amylase patent WO8901969-A -Aspergillus niger. The homologous sequence includes preregion, promoter and upstream activating sequences.; Title: strong similarity to hypothetical protein encoded by An12g06940 - Aspergillus niger; uncharacterized protein 484033 4980948 An05g02110 Aspergillus niger uncharacterized protein XP_059603730.1 482156 D 5061 CDS An05g02120 4980949 join(484327..484735,484795..485114,485166..485633) VII 1 NT_166521.1 Similarity: the ORF shows strong similarity to expressed sequence tag SEQ ID no. 7357 patent WO200056762-A2 of A. oryzae.; Title: strong similarity to hypothetical protein encoded by An12g06960 - Aspergillus niger; uncharacterized protein 485633 4980949 An05g02120 Aspergillus niger uncharacterized protein XP_059603731.1 484327 D 5061 CDS An05g02130 10098139 complement(join(486024..486581,486663..486923)) VII 1 NT_166521.1 Title: similarity to heat shock protein 40 DnaJ -Methanosarcina thermophila; See PMID 10570966; uncharacterized protein 486923 10098139 An05g02130 Aspergillus niger uncharacterized protein XP_003188683.2 486024 R 5061 CDS An05g02140 10098140 complement(join(487100..487585,487635..488048)) VII 1 NT_166521.1 Title: strong similarity to hypothetical protein encoded by An12g06610 - Aspergillus niger; uncharacterized protein 488048 10098140 An05g02140 Aspergillus niger uncharacterized protein XP_003188690.2 487100 R 5061 CDS An05g02150 84591150 join(489184..489409,489501..489580) VII 1 NT_166521.1 hypothetical protein 489580 84591150 An05g02150 Aspergillus niger hypothetical protein XP_059603732.1 489184 D 5061 CDS An05g02160 84591151 complement(join(489668..489770,489947..490014,490122..490226,490293..490396,490648..490721,491014..491202,491299..491454,491585..491749,491984..492042)) VII 1 NT_166521.1 Title: weak similarity to hypothetical myb-related protein 1 - Petunia hybrida; uncharacterized protein 492042 84591151 An05g02160 Aspergillus niger uncharacterized protein XP_059603733.1 489668 R 5061 CDS An05g02170 4980954 join(492273..492462,492523..492808,492884..493110,493188..494080) VII 1 NT_166521.1 Catalytic activity: release of a C-terminal amino acid with a broad specificity.; Function: catalyzes also peptide synthesis.; Function: removes any amino acid from the c-terminus of a long peptide, digests preferentially peptides containing a positively charged residue in P1' position, as well as arginine, lysine or phenylalanine in P1 position of ester substrate.; Induction: in the following growth conditions: acidic ph, absence of nitrogen or carbon source.; Regulation: inhibited by Dfp, and Hg(Cl)2.; Similarity: belongs to peptidase family S10; also known as the serine carboxypeptidase family.; Title: strong similarity to serine-type carboxypeptidase F CPD-II - Aspergillus niger; vacuole; uncharacterized protein 494080 4980954 An05g02170 Aspergillus niger uncharacterized protein XP_001390785.1 492273 D 5061 CDS An05g02180 84591152 join(494446..494495,494528..494675) VII 1 NT_166521.1 hypothetical protein 494675 84591152 An05g02180 Aspergillus niger hypothetical protein XP_059603734.1 494446 D 5061 CDS An05g02190 4980956 join(495504..495512,495625..495688,495985..496110,496186..496777,496846..497515) VII 1 NT_166521.1 Function: isopenicillin N epimerase of S. clavuligerus catalyses the reversible isomerisation between isopenicillin and penicillin N.; Remark: the ORF is longer than cefD of S. clavuligerus (486 compared to 397 amino acids).; Similarity: the ORF shows similarity to members of the (pyridoxal-phosphate-dependent) aminotransferase family.; Title: similarity to isopenicillin N epimerase cefD - Streptomyces clavuligerus; uncharacterized protein 497515 4980956 An05g02190 Aspergillus niger uncharacterized protein XP_001390787.3 495504 D 5061 CDS An05g02200 4980957 complement(497734..499077) VII 1 NT_166521.1 Function: M. musculus kinesin KIF21B is a microtubule-dependent motor protein for transport of essential cellular components along dendritic microtubules.; Similarity: similarity is restricted to N-terminus.; Title: similarity to kinesin Kif21b - Mus musculus; cytoskeleton; See PMID 10225949; uncharacterized protein 499077 4980957 An05g02200 Aspergillus niger uncharacterized protein XP_001390788.1 497734 R 5061 CDS An05g02210 4980958 complement(499726..500928) VII 1 NT_166521.1 Function: the PA45 gene product of the T. cruzi is a co-factor-independent proline racemase, the active site is necessary for mitogenic activity.; Title: strong similarity to B-cell mitogen precursor PA45 - Trypanosoma cruzi; See PMID 10932226; uncharacterized protein 500928 4980958 An05g02210 Aspergillus niger uncharacterized protein XP_001390789.1 499726 R 5061 CDS An05g02220 4980959 complement(join(501259..501940,502115..502173)) VII 1 NT_166521.1 Catalytic activity: (S)-2-Haloacid + H2O = (R)-2-Hydroxyacid + Halide.; Function: catalyzes hydrolytic cleavage of halogen-carbon bonds of C2-halogenated alkanoic acids to yield 2-hydroxy or 2-oxo acids.; Title: similarity to 2-haloacid dehalogenase -Pseudomonas putida; See PMID 7764511; uncharacterized protein 502173 4980959 An05g02220 Aspergillus niger uncharacterized protein XP_059603735.1 501259 R 5061 CDS An05g02230 4980960 complement(join(502410..503713,503778..504183)) VII 1 NT_166521.1 Title: strong similarity to hypothetical protein PA1259 - Pseudomonas aeruginosa; uncharacterized protein 504183 4980960 An05g02230 Aspergillus niger uncharacterized protein XP_059603736.1 502410 R 5061 CDS An05g02240 84591153 join(504800..505115,505197..505380,505428..505499,505581..505686,505752..505829,505878..506057,506098..506217) VII 1 NT_166521.1 Function: the nerA gene product of A. radiobacter removes central or terminal nitro-groups from nitroglycerin and related esters as nitrite.; Similarity: contains FMN oxidoreductase domain.; Similarity: similarities to pro- and eukaryotic xenobiotic reductases (NADPH dehydrogenases, EC 1. 6. 99. 1).; Similarity: similarity to morphinone reductase of P. putida and old yellow enzyme (OYE) from S. cerevisiae.; Similarity: the nerA gene product of A. radiobacter belongs to the alpha/beta barrel flavoprotein group of proteins.; Title: strong similarity to glycerol trinitrate reductase nerA - Agrobacterium radiobacter; See PMID 9401040; uncharacterized protein 506217 84591153 An05g02240 Aspergillus niger uncharacterized protein XP_059603737.1 504800 D 5061 CDS An05g02250 4980962 join(506997..507731,507870..507905) VII 1 NT_166521.1 Similarity: similarities predominantly correspond to multiple serine and threonine residues.; Title: similarity to hypothetical serine-threonine rich protein - Schizosaccharomyces pombe; uncharacterized protein 507905 4980962 An05g02250 Aspergillus niger uncharacterized protein XP_059603738.1 506997 D 5061 CDS An05g02260 4980963 complement(join(508121..509069,509122..509129,509198..509320,509369..509374)) VII 1 NT_166521.1 Catalytic activity: xylitol + NAD(+) <=> D-xylulose + NADH.; Cofactor: zinc 2+; Similarity: similarities to L-Iditol 2-dehydrogenases (EC 1. 1. 1. 14).; Title: strong similarity to xylitol dehydrogenase xdh - Galactocandida mastotermitis; See PMID 10661867; uncharacterized protein 509374 4980963 An05g02260 Aspergillus niger uncharacterized protein XP_001390794.1 508121 R 5061 CDS An05g02270 4980964 complement(join(<510185..510441,510485..510539,510591..510663,510716..510908,510959..511549,511621..511868)) VII 1 NT_166521.1 Title: strong similarity to hypothetical protein B15I20.50 - Neurospora crassa [putative frameshift]; putative frameshift; uncharacterized protein 511868 4980964 An05g02270 Aspergillus niger uncharacterized protein XP_059603739.1 510185 R 5061 CDS An05g02280 4980965 complement(join(512590..513483,513537..513770)) VII 1 NT_166521.1 Function: the Alcaligenes esterase is capable of resolving paroxetine methyl ester and/or ethyl ester to give an enantiomer excess of the (-) isomer greater than 90%.; Remark: the Alcaligenes esterase can be used for the stereospecific hydrolysis of paroxetine esters for use in the production of an active paroxetine isomer.; Title: similarity to esterase from patent WO9802556-A2 - Alcaligenes sp.; uncharacterized protein 513770 4980965 An05g02280 Aspergillus niger uncharacterized protein XP_001390796.1 512590 R 5061 CDS An05g02290 84591154 complement(join(514874..514979,515073..515233)) VII 1 NT_166521.1 hypothetical protein 515233 84591154 An05g02290 Aspergillus niger hypothetical protein XP_059603740.1 514874 R 5061 CDS An05g02300 4980967 join(515305..515537,515588..515780,515835..516281) VII 1 NT_166521.1 Title: similarity to secreted protein SEQ ID NO:127 from patent WO200061779-A1 - Homo sapiens; uncharacterized protein 516281 4980967 An05g02300 Aspergillus niger uncharacterized protein XP_059603741.1 515305 D 5061 CDS An05g02310 4980968 complement(join(516379..516721,516778..517478)) VII 1 NT_166521.1 Alternative name: BCG21, CSG1; Function: the S. cerevisae Sur1 gene product is necessary for mannosylation of the sphingolipid inositolphosphorylceramide.; Pathway: mannose-inositol-P-ceramide (MIPC) metabolism.; Remark: the S. cervisiae Sur1 gene product suppresses certain phenotype of rvs161 mutants including reduced viability upon starvation.; Remark: the S. cervisiae Sur1 gene product suppresses the Ca(2+)-sensitive phenotype of the csg2 mutant.; Title: strong similarity to sphingolipid metabolism Sur1 - Saccharomyces cerevisiae; See PMID 7785328; See PMID 7854312; See PMID 9323360; uncharacterized protein 517478 4980968 An05g02310 Aspergillus niger uncharacterized protein XP_001390799.1 516379 R 5061 CDS An05g02320 4980969 join(518547..518718,518782..519161,519222..519675,519778..519992) VII 1 NT_166521.1 Function: the P. Pastoris enzyme is involved in sugar chain extension of glycoproteins.; Title: similarity to alpha-1,6-mannosyltransferase from patent JP09003097-A - Pichia pastoris; uncharacterized protein 519992 4980969 An05g02320 Aspergillus niger uncharacterized protein XP_059603742.1 518547 D 5061 CDS An05g02330 4980970 complement(520092..521621) VII 1 NT_166521.1 Function: the cap59 gene product is essential for capsule formation and for pathogenicity of C. neoformans.; Similarity: similarity is restricted to the central region of the protein.; Title: similarity to capsule protein CAP59 -Cryptococcus neoformans; See PMID 8007987; uncharacterized protein 521621 4980970 An05g02330 Aspergillus niger uncharacterized protein XP_001390801.1 520092 R 5061 CDS An05g02340 4980971 complement(join(522117..522290,522363..523265,523332..523627,523686..523992)) VII 1 NT_166521.1 Catalytic activity: 4 benzenediol + o(2) = 4 benzosemiquinone + 2 H(2)O.; Cofactor: binds 4 cu-ions per molecule. Three distinct Cu centres known as type1 or blue, type 2 or normal, and type 3 or coupled binuclear (by similarity).; Function: lignin degradation and detoxification of lignin-derived products (probable).; Localization: secreted (potential).; Similarity: belongs to the family of multicopper oxidases.; Similarity: contains 3 plastocyanin-like domains.; Title: strong similarity to precursor of laccase -Neurospora crassa; See PMID 2947240; See PMID 2961749; uncharacterized protein 523992 4980971 An05g02340 Aspergillus niger uncharacterized protein XP_001390802.1 522117 R 5061 CDS An05g02350 4980972 join(525548..525707,525760..526154) VII 1 NT_166521.1 Gene-ID: Arsa-48; Remark: Arsa-48 from A. niger is differentially expressed in the pellet morphology relative to the filamentous morphology.; differential expressed Arsa-48 from patent US2003215950-A1-Aspergillus niger 526154 Arsa-48 4980972 Arsa-48 Aspergillus niger differential expressed Arsa-48 from patent US2003215950-A1-Aspergillus niger XP_001390803.1 525548 D 5061 CDS An05g02360 10098141 complement(join(526754..527234,527284..527290,527440..527793,527859..528177)) VII 1 NT_166521.1 Similarity: similarity is restricted to N-terminus.; Title: strong similarity to hypothetical protein encoded by An18g01530 - Aspergillus niger; uncharacterized protein 528177 10098141 An05g02360 Aspergillus niger uncharacterized protein XP_059603743.1 526754 R 5061 CDS An05g02370 4980974 <528835..530238 VII 1 NT_166521.1 Function: TRI101 of F. sporotrichioides 3-O-acetylates trichothecene mycotoxins (such as T-2 toxin), it converts isotrichodermol to isotrichodermin.; Pathway: TRI101 of F. sporotrichioides is necessary for the biosynthesis of T-2 toxin.; Phenotype: disruption of TRI101 of F. sporotrichioides leads to accumulation of T-2 toxin biosynthesis products.; Remark: a putative sequencing error was corrected by introducing a frame shift of 1bp.; Remark: trichothecene mycotoxins are toxic for eukaryotic organisms (they act as protein synthesis inhibitors); 3-O-acetylation, however, converts the trichothecene mycotoxins in untoxic compounds; thus, TRI101 acts for F. sporotrichioides, which produces trichothecenes, as a resistance protein.; Title: strong similarity to trichothecene 3-O-acetyltransferase TRI101 - Fusarium sporotrichioides [putative frameshift]; putative frameshift; See PMID 9762900; See PMID 10583973; uncharacterized protein 530238 4980974 An05g02370 Aspergillus niger uncharacterized protein XP_059603744.1 528835 D 5061 CDS An05g02380 4980975 join(530649..530984,531050..532508,532563..532615) VII 1 NT_166521.1 Function: vbs of A. parasiticus cyclizes the versiconal hemiacetal to an optically active product whose absolute configuration is crucial to the interaction of aflatoxin B1 with DNA.; Pathway: vbs of A. parasiticus is a crucial enzyme in the aflatoxin biosynthetic pathway.; Remark: aflatoxin B1 is a potent environmental carcinogen.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Remark: the ORF shows similarity to A. niger glucose oxidase patent US5516671-A and patent WO9514784-A.; Title: strong similarity to versicolorin B synthase vbs - Aspergillus parasiticus; See PMID 8784203; See PMID 8995367; uncharacterized protein 532615 4980975 An05g02380 Aspergillus niger uncharacterized protein XP_001390806.1 530649 D 5061 CDS An05g02390 4980976 complement(join(533074..533981,534040..534617,534675..535117)) VII 1 NT_166521.1 Function: 6-HDNO (EC: 1. 5. 3. 6.) of Arthrobacter oxidans oxidizes 6-hydroxy-D-nicotine to 6-hydroxy-N-methylmyosmine.; Induction: 6-HDNO of A. oxidans is induced by nicotine.; Pathway: 6-HDNO of A. oxidans is involved in nicotine degradation.; Similarity: the ORF shows local similarity to 6-HDNO of Arthrobacter oxidans: the Arthrobacter protein is shorter in length (458 compared to 642 amino acids) and the alignment between the two proteins encompasses only about 150 amino acids.; Similarity: the ORF shows much stronger and overall similarity to the probable isoamyl alcohol oxidase mreA of A. oryzae.; Similarity: the ORF shows similarity to some unspecified oxidoreductases.; Title: similarity to 6-hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 2680607; See PMID 3622516; uncharacterized protein 535117 4980976 An05g02390 Aspergillus niger uncharacterized protein XP_001390807.1 533074 R 5061 CDS An05g02400 4980977 join(537355..537407,537464..538010) VII 1 NT_166521.1 Function: NUM1 of S. cerevisiae controls cytoplasmic microtubule functions and nuclear migration through the bud neck in anaphase cells.; Function: NUM1 of S. cerevisiae controls nuclear migration by forming dynein-interacting cortical cytoplasmic microtubule capture sites at both cellular poles.; Similarity: NUM1 of S. cerevisiae is about 13 times longer than the ORF; additionally, the alignment between the two proteins encompasses only about 100 amino acids.; Title: weak similarity to nuclear migration protein Num1 - Saccharomyces cerevisiae; See PMID 1745235; uncharacterized protein 538010 4980977 An05g02400 Aspergillus niger uncharacterized protein XP_001390808.3 537355 D 5061 CDS An05g02410 4980978 complement(join(538343..538472,538577..538987,539041..540446)) VII 1 NT_166521.1 Catalytic activity: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate.; Function: GUSB of C. familiaris degrades glycosaminoglycans.; Pathway: GUSB of C. familiaris is involved in starch and sucrose metabolism and glycosaminoglycan degradation.; Phenotype: mutation of GUSB in C. familiaris leads to the lysosomal storage disease mucopolysaccharidosis VII,which is characterized by accumulation of glycosaminoglycans in the lysosomes.; Remark: GUSB of C. familiaris belongs to family 2 of glycosyl hydrolases.; Similarity: GUSB of C. familiaris has the same length as the ORF; however, about 170 C-terminal amino acids are not included in the alignment between the two proteins.; Title: strong similarity to beta-glucuronidase GUSB - Canis lupus; lysosome; See PMID 9987917; uncharacterized protein 540446 4980978 An05g02410 Aspergillus niger uncharacterized protein XP_001390809.1 538343 R 5061 CDS An05g02420 4980979 complement(join(540846..541249,541305..541369,541432..541829,541887..541991,542047..542193)) VII 1 NT_166521.1 Function: pth11 of the phytopathogenic fungus M. grisea is involved in host surface recognition.; Localization: pth11 of M. grisea was localized to the cell membrane and vacuoles.; Phenotype: mutants of pth11 of M. grisea are nonpathogenic due to a defect in appressorium differentiation.; Remark: pth11 of M. grisea is presumably not required for appressorium morphogenesis but is involved in host surface recognition.; Similarity: pth11 of M. grisea is much longer than the ORF (631 compared to 372 amino acids); the two proteins show similarity only at an N-terminal stretch of 265 amino acids.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529; uncharacterized protein 542193 4980979 An05g02420 Aspergillus niger uncharacterized protein XP_001390810.1 540846 R 5061 CDS An05g02430 84591155 complement(join(542653..542949,543014..543127)) VII 1 NT_166521.1 Remark: the ORF overlaps with ~25 C-terminal nucleotides of the A. niger pgaC gene (in EMBL:ANPGAC and in PATENTDNA:Q11274) of the neighbouring ORF (cqnw. 00. tfa_105wk).; hypothetical protein 543127 84591155 An05g02430 Aspergillus niger hypothetical protein XP_059603745.1 542653 R 5061 CDS An05g02440 4980981 complement(join(543399..543730,543784..543913,543970..544395,544471..544737)) VII 1 NT_166521.1 Catalytic activity: pgaC of A. niger hydrolysis randomly 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans.; Function: pgaC of A. niger is involved in the degradation of pectin (a polygalacturonide).; Gene-ID: pgaC; Remark: in PIR S24156 pgaC is described as protein of A. nidulans. This is presumably a mistake, since the linked EMBL sequence (with identical protein sequence) and the linked PubMed article describe pgaC as an A. niger protein.; Remark: pgaC of A. niger belongs to family 28 of glycosyl hydrolases (polygalacturonases).; Remark: pgaC of A. niger is also called polygalacturonase III.; Similarity: the ORF is identical to pgaC of A. niger with the exception of one additional alanine at position 20.; Similarity: the ORF overlaps with the A. niger prepro-polygalacturonase C from patent EP421919-A.; See PMID 1511691; polygalacturonase III precursor pgaC-Aspergillus niger 544737 pgaC 4980981 pgaC Aspergillus niger polygalacturonase III precursor pgaC-Aspergillus niger XP_001390812.1 543399 R 5061 CDS An05g02450 4980982 complement(join(547307..548394,548466..548739,548781..548905,548989..549031,549092..549188,549276..549400)) VII 1 NT_166521.1 Function: bhaA of A. mediterranei is a halogenase involved in the biosynthesis of the glycopeptide antibiotic balhimycin.; Similarity: the ORF shows local similarity to bhaA of A. mediterranei: the two proteins overlap N-terminally (up to amino acid 350).; Title: similarity to halogenase bhaA from patent DE19926770-A1 - Amycolatopsis mediterranei; See PMID 10390204; uncharacterized protein 549400 4980982 An05g02450 Aspergillus niger uncharacterized protein XP_059603746.1 547307 R 5061 CDS An05g02460 4980983 complement(join(551244..552749,552801..552869)) VII 1 NT_166521.1 Similarity: the ORF is 286 amino acids longer at the N-terminus than the hypothetical protein TM1177 of T. maritima.; Similarity: the ORF shows weak similarity to putative hydrolases.; Title: similarity to hypothetical conserved protein TM1177 - Thermotoga maritima; uncharacterized protein 552869 4980983 An05g02460 Aspergillus niger uncharacterized protein XP_001390814.1 551244 R 5061 CDS An05g02470 4980984 join(553575..553790,553845..554409,554453..554682,554735..555014,555068..555301,555415..556106,556168..556333,556393..556734,556801..557056,557366..558013,558118..558570,558658..558874) VII 1 NT_166521.1 Function: The YCF1 gene from S. cerevisiae is required for cadmium resistance.; Remark: S. cerevisiae cells harboring a deletion of the YCF1 gene are hypersensitive to cadmium compared with wild type cells.; Similarity: YCF1 of S. cerevisiae belongs to the ATP-binding transport family (ABC transporters) and the MDR subfamily.; Title: strong similarity to cadmium resistance protein Ycf1 - Saccharomyces cerevisiae; See PMID 7521334; See PMID 10790694; uncharacterized protein 558874 4980984 An05g02470 Aspergillus niger uncharacterized protein XP_059603747.1 553575 D 5061 CDS An05g02480 84591156 join(559365..559920,559987..560052,560145..561214) VII 1 NT_166521.1 Title: similarity to hypothetical protein PA2336 -Pseudomonas aeruginosa; uncharacterized protein 561214 84591156 An05g02480 Aspergillus niger uncharacterized protein XP_059603748.1 559365 D 5061 CDS An05g02490 4980986 complement(join(562426..562756,562816..562907,562984..563568,563627..564044,564123..564522,564572..564614)) VII 1 NT_166521.1 Function: FacB of A. nidulans is a regulatory gene involved in acetamide and acetate utilisation.; Remark: FacB of A. nidulans is probably a DNA-binding transcriptional activator.; Remark: Similarity to FacB is restricted to N-terminal part of protein.; Similarity: FacB of A. nidulans has a N-terminal GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster for DNA binding, a leucine zipper-like heptad repeat motifs and central and C-terminal acidic alpha-helical regions.; Similarity: the predcited ORF show similarity to several transciption factors.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; See PMID 9197408; uncharacterized protein 564614 4980986 An05g02490 Aspergillus niger uncharacterized protein XP_001390817.1 562426 R 5061 CDS An05g02500 4980987 complement(join(564934..566103,566168..566242,566308..566379)) VII 1 NT_166521.1 Title: strong similarity to hypothetical protein HI0753 - Synechocystis sp.; uncharacterized protein 566379 4980987 An05g02500 Aspergillus niger uncharacterized protein XP_001390818.1 564934 R 5061 CDS An05g02510 4980988 join(566924..567317,567369..567458,567520..567929,567993..568184,568245..568763) VII 1 NT_166521.1 Title: strong similarity to galactose-proton symporter galP - Escherichia coli; See PMID 6300086; uncharacterized protein 568763 4980988 An05g02510 Aspergillus niger uncharacterized protein XP_001390819.1 566924 D 5061 CDS An05g02520 4980989 complement(join(569363..569694,569754..569974,570021..570692,570746..570905,570975..571176,571225..571342,571410..571444)) VII 1 NT_166521.1 Title: strong similarity to hypothetical protein SCD10.11 - Streptomyces coelicolor; uncharacterized protein 571444 4980989 An05g02520 Aspergillus niger uncharacterized protein XP_059603749.1 569363 R 5061 CDS An05g02530 4980990 join(572390..572661,572718..572926,572991..573700,573760..573842,573895..573973,574034..574321,574639..574747,574849..575000,575078..575335) VII 1 NT_166521.1 Function: the formyl-CoA transferase frc from Oxalobacter formigenes catalyzes the transfer of CoA from formyl-CoA to either oxalate or succinate.; Pathway: in Oxalobacter formigenes oxalic acid, a highly toxic by-product of metabolism, is catabolized by utilizing an activation-decarboxylation reaction which yields formate and CO2. The formyl-CoA transferase frc is involved at this detoxification step.; Similarity: Strong similarity to N-terminal part of many hypothetical proteins, hypothetical fatty acid co-A racemases and frc of O. formigenes.; Title: similarity to formyl-CoA transferase frc -Oxalobacter formigenes; See PMID 9150242; See PMID 2361939; uncharacterized protein 575335 4980990 An05g02530 Aspergillus niger uncharacterized protein XP_059603750.1 572390 D 5061 CDS An05g02540 4980991 join(578611..578857,578920..579394,579469..580513) VII 1 NT_166521.1 Catalytic activity: 4 benzenediol + O(2) <=> 4 benzosemiquinone + 2 H(2)O.; Cofactor: Copper.; Function: Laccase I from E. nidulans is a p-diphenol oxidase which is needed for synthesis of green conidial pigment.; Function: Laccases are a group of multi-copper proteins of low specificity acting on both catechol and p-benzenediol, and often acting also on aminophenols and phenylenediamine.; Function: The laccase I from E. nidulans catalyzes the oxidation of benzendiol to benzosemiquinone by molecular oxygen.; Remark: the 1990 decribed (Pubmed 2192364) yA gene from E. nidulans encodes the previous 1982 purified laccase I enzyme (Pubmed 7050088), which differs from the laccase II enzyme (Pubmed 6341366).; Title: strong similarity to laccase I precursor yA -Aspergillus nidulans; See PMID 7050088; See PMID 2192364; See PMID 2659435; uncharacterized protein 580513 4980991 An05g02540 Aspergillus niger uncharacterized protein XP_001390822.1 578611 D 5061 CDS An05g02550 84591157 join(581713..581805,581842..581944,582009..582402,582466..582525,582592..582781,582851..583558) VII 1 NT_166521.1 Function: HOL1 of S. cerevisiae, which belongs to th multidrug efflux transporters family, seems also to be involved in ions transport.; Function: multidrug transporters are membrane proteins which, by an unknown mechanism, recognize diverse toxic compounds and efflux them from cells.; Similarity: the predicted ORF shows similarity to members of the multidrug efflux transporters belonging to the major facilitator superfamily of transport proteins.; Title: strong similarity to multidrug resistance protein Hol1 - Saccharomyces cerevisiae; See PMID 8543057; See PMID 8955402; See PMID 9046086; See PMID 9348664; See PMID 2405251; uncharacterized protein 583558 84591157 An05g02550 Aspergillus niger uncharacterized protein XP_059603751.1 581713 D 5061 CDS An05g02560 4980993 complement(join(584123..585047,585099..585220,585272..585295,585380..585400,585774..586430,586561..586686)) VII 1 NT_166521.1 Function: amdA in E. nidulans regulates the expression of the gene encoding acetamidase, amdS.; Similarity: the predicted ORF contains also two leucine-zipper motifs, common to transcription regulators.; Similarity: the similarity of the predicted ORF to amdA of E. nidulans and other transcription factors is mainly due to the presence of a C2H2 zinc-finger motiv.; Title: similarity to zinc-finger transcription factor amdA - Aspergillus nidulans; See PMID 7596297; uncharacterized protein 586686 4980993 An05g02560 Aspergillus niger uncharacterized protein XP_059603752.1 584123 R 5061 CDS An05g02570 4980994 join(587382..587607,587672..587751,587811..588097,588155..588176,588243..588442,588520..588662,588717..589534) VII 1 NT_166521.1 Catalytic activity: 3-(3-hydroxyphenyl)propionate + NADH + O2 <=> H2O + 3-(2,3-dihydroxyphenyl)propionate + NAD.; Cofactor: there is evidence that the E. coli enzyme may use FAD as a cofactor.; Function: the gene mhpA of E. coli has been identified with the 3-(3-hydroxyphenyl)propionate 2-hydroxylase activity.; Remark: E. coli is able to utilize aromatic acids as carbon and energy sources. A meta-cleavage pathway is used for the catabolism of 3-(3-hydroxyphenyl)propionate.; Title: similarity to 3-(3-hydroxyphenyl)propionate hydroxylase mhpA - Escherichia coli; See PMID 3531186; See PMID 6345502; See PMID 9098055; uncharacterized protein 589534 4980994 An05g02570 Aspergillus niger uncharacterized protein XP_059603753.1 587382 D 5061 CDS An05g02580 4980995 join(590747..590863,590956..591125,591180..591411,591474..591953) VII 1 NT_166521.1 Function: trihydroxytoluene oxygenase of B. cepacia catalyzes the conversion of 2,4,5-trihydroxytoluene to 2,4-dihydroxy-5-methyl-6-oxy-2,4-hexadienoic acid in the 2,4-dinitrotoluene metabolism pathway.; Function: trihydroxytoluene oxygenase of B. cepacia is a meta-ring cleavage dioxygenase.; Title: strong similarity to trihydroxytoluene oxygenase dntD - Burkholderia cepacia; See PMID 8449889; uncharacterized protein 591953 4980995 An05g02580 Aspergillus niger uncharacterized protein XP_059603754.1 590747 D 5061 CDS An05g02590 4980996 complement(join(592441..592750,592802..593175,593232..593420)) VII 1 NT_166521.1 Remark: the expression pattern of HIH-3 and its homology with HHDDI indicate that it plays a role in cancers (e. g., leukaemia, testicular cancer and melanomas) and immune disorders (e. g., asthma and atherosclerosis).; Similarity: the predicted ORF, as well as HIH-3 have chemical and structural homology with Methanococcus iannaschii 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDDI).; Title: strong similarity to isomerase homologue-3 HIH-3 from patent US5989860-A - Homo sapiens; uncharacterized protein 593420 4980996 An05g02590 Aspergillus niger uncharacterized protein XP_059603755.1 592441 R 5061 CDS An05g02600 4980997 join(594325..594402,594548..596351,596396..596448) VII 1 NT_166521.1 Function: QUTA is a positively acting regulatory protein that regulates the expression of the eight genes comprising the quinic acid utilization gene (qut) gene cluster in A. nidulans.; Similarity: It has been proposed that the QUTA protein is composed of two domains that are related to the N-terminal two domains-dehydroquinate (DHQ) synthase and 5-enolpyruvyl shikimate-3-phosphate (EPSP) synthase-of the pentadomain AROM protein.; Similarity: the predicted ORF is shorter than A. nidulans QUTA; the presence of the fungal Zn(2)-Cys(6) binuclear cluster strongly suggests a role as transcription factor.; Title: strong similarity to regulator protein qutA -Aspergillus nidulans; See PMID 3313276; See PMID 8581174; See PMID 8704987; uncharacterized protein 596448 4980997 An05g02600 Aspergillus niger uncharacterized protein XP_001390828.3 594325 D 5061 CDS An05g02610 4980998 complement(join(597791..598309,598362..598441,598663..598912,599225..599870,599922..600103)) VII 1 NT_166521.1 Similarity: the N-terminal region of the predicted ORF contains a fungal Zn(2)-Cys(6) binuclear cluster domain, a cysteine-rich region that binds DNA, and is found in many fungal transcriptional activators.; Similarity: the ORF shows weak similarity to the putative transcriptional regulator FCR1 of C. albicans.; Similarity: the predicted ORF shows also similarity to several putative transcription factors.; Title: similarity to hypothetical protein EAA63118.1 - Aspergillus nidulans; See PMID 9864335; uncharacterized protein 600103 4980998 An05g02610 Aspergillus niger uncharacterized protein XP_059603756.1 597791 R 5061 CDS An05g02620 84591158 complement(join(601244..601823,601880..601977,602013..602196,602257..602278,602322..602358)) VII 1 NT_166521.1 Similarity: shows similarity to proteins containing Fungal Zn(2)-Cys(6) binuclear cluster domains i. e. mainly transcriptional regulatory proteins.; Title: similarity to hypothetical transcriptional regulator FCR1 - Candida albicans; See PMID 9864335; uncharacterized protein 602358 84591158 An05g02620 Aspergillus niger uncharacterized protein XP_059603757.1 601244 R 5061 CDS An05g02630 84591159 complement(join(602796..602966,603064..603069)) VII 1 NT_166521.1 Similarity: the weak similarity is due to a short,very well conserved stretch of amino acids.; Title: weak similarity to hypothetical phototropin AcNPH1 - Adiantum capillusveneris; uncharacterized protein 603069 84591159 An05g02630 Aspergillus niger uncharacterized protein XP_059603758.1 602796 R 5061 CDS An11g00010 4984233 complement(1592..4000) VII 1 NT_166526.1 Function: Mx proteins have antiviral activities.; Induction: Mx proteins are induced by interferon n response to double-stranded RNA.; Similarity: Mx proteins belong to a GTPase family that includes rat dynamin, Drosophila Shibire and the yeast proteins Vps1/Spo15 and Mgm1.; Similarity: similarity is between the N-terminal 3/4s of the predicted A. niger protein and O. mykiss Mx1,which is 200 aa shorter.; Title: similarity to antiviral GTPase Mx1 -Oncorhynchus mykiss; See PMID 7507812; See PMID 8528941; uncharacterized protein 4000 4984233 An11g00010 Aspergillus niger uncharacterized protein XP_059605415.1 1592 R 5061 CDS An11g00020 84592162 complement(join(5402..5422,5497..5754,5945..6013)) VII 1 NT_166526.1 hypothetical protein 6013 84592162 An11g00020 Aspergillus niger hypothetical protein XP_059605416.1 5402 R 5061 CDS An11g00030 84592163 join(7094..7188,7292..7336,7385..7628) VII 1 NT_166526.1 hypothetical protein 7628 84592163 An11g00030 Aspergillus niger hypothetical protein XP_059605417.1 7094 D 5061 CDS An11g00040 4984231 join(7827..8061,8122..8231) VII 1 NT_166526.1 Title: weak similarity to cDNA for 59-kDa readthrough protein RT - Sorghum chlorotic spot virus; See PMID 10772992; uncharacterized protein 8231 4984231 An11g00040 Aspergillus niger uncharacterized protein XP_001394008.1 7827 D 5061 CDS An11g00050 4984252 complement(join(8623..12114,12246..19982,20050..20484)) VII 1 NT_166526.1 Function: F. scirpi esyn1 is a multifunctional enzyme with N-methyltransferase and peptide synthetase activity required for N-Methylcyclopeptide antibiotica biosynthesis.; Title: strong similarity to enniatin synthase esyn1 - Fusarium scirpi; See PMID 8483420; See PMID 2205497; uncharacterized protein 20484 4984252 An11g00050 Aspergillus niger uncharacterized protein XP_059605418.1 8623 R 5061 CDS An11g00060 4984258 complement(join(22376..22709,22767..22862,22927..23306,23363..23430,23486..23542,23597..23792)) VII 1 NT_166526.1 Function: M. grisea pth11p is a novel plasma membrane protein that mediates appressorium differentiation in response to inductive substrate cues.; Localization: integral membrane protein.; Similarity: similarity is resticted to aminoterminal part of M. grisea pth11.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529; uncharacterized protein 23792 4984258 An11g00060 Aspergillus niger uncharacterized protein XP_001394010.1 22376 R 5061 CDS An11g00070 4984246 join(24889..25083,25301..25507,25542..26031,26104..26414) VII 1 NT_166526.1 Catalytic activity: omtB of A. parasiticus catalyzes the conversion of demethylsterigmatocystin (DMST) to sterigmatocystin (ST) and dihydrodemethylsterigmatocystin (DHDMST) to dihydrosterigmatocystin (DHST).; Function: omtB of A. parasiticus is involved in the aflatoxin biosynthesis.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Similarity: shows no similarity at the aminoterminus of the A. parasiticus protein.; Similarity: shows similarity to several O-methyltransferases.; Title: strong similarity to O-methyltransferase B omtB - Aspergillus parasiticus; See PMID 8434913; uncharacterized protein 26414 4984246 An11g00070 Aspergillus niger uncharacterized protein XP_059605419.1 24889 D 5061 CDS An11g00080 4984248 complement(join(26946..27322,27470..27534,27589..27971,28027..28290)) VII 1 NT_166526.1 Similarity: shows only partial similarity to M. grisea protein.; Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea; uncharacterized protein 28290 4984248 An11g00080 Aspergillus niger uncharacterized protein XP_059605420.1 26946 R 5061 CDS An11g00090 4984256 complement(join(34405..34781,34841..34948,35000..35131,35188..35454,35610..35775,35856..35882)) VII 1 NT_166526.1 Similarity: the ORF encoded protein shows alsoweak similarity to the hypothetical protein B24M22. 80 from Neurospora crassa .; Title: similarity to hypothetical membrane protein pth - Blumeria graminis; uncharacterized protein 35882 4984256 An11g00090 Aspergillus niger uncharacterized protein XP_059605421.1 34405 R 5061 CDS An11g00100 4984228 complement(join(36325..36455,36563..36628,36685..36717,36889..37824,37881..38460)) VII 1 NT_166526.1 Catalytic activity: triacylglycerol lipases catalyse triacylglycerol + H(2)O <=> diacylglycerol + a fatty acid anion.; Similarity: shows similarity to several carboxylesterase and lipases (EC 3. 1. 1. -).; Title: strong similarity to triacylglycerol lipase Lip5 - Candida rugosa; uncharacterized protein 38460 4984228 An11g00100 Aspergillus niger uncharacterized protein XP_001394014.3 36325 R 5061 CDS An11g00110 4984242 complement(join(41114..41552,41612..41826,41886..41971,42021..42096)) VII 1 NT_166526.1 Function: levels of intracellular and extracellular cutinase activity increase in response to growth in the presence of cutin.; Function: the gene of M. grisea is expressed when cutin is the sole carbon source but not when the carbon source is cutin and glucose together or glucose alone.; Title: strong similarity to cutinase CUT1 -Magnaporthe grisea; See PMID 1557023; uncharacterized protein 42096 4984242 An11g00110 Aspergillus niger uncharacterized protein XP_001394015.1 41114 R 5061 CDS An11g00120 4984264 complement(join(43347..43429,43497..44102,44166..44621,44702..44971,45081..45198)) VII 1 NT_166526.1 Similarity: shows similarity to several fungal sugar transporter.; Title: similarity to glucose permease Rgt2 -Saccharomyces cerevisiae; See PMID 9335584; uncharacterized protein 45198 4984264 An11g00120 Aspergillus niger uncharacterized protein XP_001394016.1 43347 R 5061 CDS An11g00130 4984227 join(45754..45950,45992..46010,46042..46255,46325..46983,47034..47705) VII 1 NT_166526.1 Function: a B. subtilis PNB carboxy-esterase (PNBCE) that catalyzes hydrolysis of several beta-lactam antibiotic PNB esters to the corresponding free acid and PNB alcohol.; Title: similarity to p-nitrobenzyl esterase pnbA -Bacillus subtilis; uncharacterized protein 47705 4984227 An11g00130 Aspergillus niger uncharacterized protein XP_059605422.1 45754 D 5061 CDS An11g00140 84592164 complement(join(47821..48216,48307..48658,48713..48943,49006..49148)) VII 1 NT_166526.1 Similarity: shows only similarity to carboxyterminal part of the xlnR product.; Title: similarity to xylanolytic transcriptional activator xlnR - Aspergillus niger; See PMID 9758775; uncharacterized protein 49148 84592164 An11g00140 Aspergillus niger uncharacterized protein XP_059605423.1 47821 R 5061 CDS An11g00150 4984234 complement(join(50765..51139,51204..51614)) VII 1 NT_166526.1 Similarity: the ORF encoded protein shows also weak similarity to hypothetical protein SC3A7. 19 from Streptomyces coelicolor and to putative the esterase estC of Burkholderia gladioli.; Title: similarity to hypothetical protein CAC04238.1 - Streptomyces coelicolor; uncharacterized protein 51614 4984234 An11g00150 Aspergillus niger uncharacterized protein XP_001394019.1 50765 R 5061 CDS An11g00160 84592165 complement(join(51913..52172,52219..52405)) VII 1 NT_166526.1 hypothetical protein 52405 84592165 An11g00160 Aspergillus niger hypothetical protein XP_059605424.1 51913 R 5061 CDS An11g00170 4984243 join(52961..52990,53050..53116,53185..53498) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein encoded by An01g05460 - Aspergillus niger; uncharacterized protein 53498 4984243 An11g00170 Aspergillus niger uncharacterized protein XP_001394021.1 52961 D 5061 CDS An11g00180 4984249 complement(join(53793..54091,54284..54423,54678..54723,54783..54942,55214..55414,55562..55875,56031..56109)) VII 1 NT_166526.1 Similarity: shows only short similarity at aminoterminus to carboxyterminus of enzyme of P. paucimobilis.; Title: weak similarity to lignostilbene alphabeta-dioxygenase I lsdB - Pseudomonas paucimobilis; uncharacterized protein 56109 4984249 An11g00180 Aspergillus niger uncharacterized protein XP_059605425.1 53793 R 5061 CDS An11g00190 84592166 join(57056..57513,57809..57861,57916..58082) VII 1 NT_166526.1 Similarity: shows only partial similarity to several sugar and other transporter proteins.; Title: weak similarity to high affinity glucose transporter HGT1 - Kluyveromyces lactis; uncharacterized protein 58082 84592166 An11g00190 Aspergillus niger uncharacterized protein XP_059605426.1 57056 D 5061 CDS An11g00200 4984238 join(60058..60181,60235..60428,60475..60527,60586..60808,60859..61105,61155..61317,61367..62660) VII 1 NT_166526.1 Function: it functions at low pH to liberate aroma-rich terpenes and aroma precursor compounds.; Function: the enzyme of C. Candida molischiana is a member of the family-3 glycosyl hydrolases.; Title: strong similarity to beta-glucosidase bgln -Candida molischiana; cell wall; See PMID 10554245; uncharacterized protein 62660 4984238 An11g00200 Aspergillus niger uncharacterized protein XP_001394024.1 60058 D 5061 CDS An11g00210 4984261 63132..64793 VII 1 NT_166526.1 Function: enzyme of B. sp. is a flavin dependent monooxygenase; contains FAD; requires NADPH.; Function: it is involved in the degradation of cyclohexanone.; Remark: putative sequencing error results in a premature STOP codon.; Title: strong similarity to cyclohexanone monooxygenase chnB2 - Brevibacterium sp. [putative sequencing error]; putative sequencing error; See PMID 10894733; uncharacterized protein 64793 4984261 An11g00210 Aspergillus niger uncharacterized protein XP_059605427.1 63132 D 5061 CDS An11g00220 4984230 join(65772..66203,66262..66302,66353..66673,66725..66954,67007..67059,67109..67230,67284..68453,68565..68634,68810..68857) VII 1 NT_166526.1 Function: C. albicans CFL1 encodes a functional ferric reductase activity that can rescue a S. cerevisiae fre1 mutant.; Similarity: shows no similarity to ferric reductases at aminoterminus.; Title: similarity to ferric reductase cfl1 - Candida albicans; See PMID 10784045; uncharacterized protein 68857 4984230 An11g00220 Aspergillus niger uncharacterized protein XP_059605428.1 65772 D 5061 CDS An11g00230 4984259 complement(join(69461..69951,70123..70906)) VII 1 NT_166526.1 Similarity: similarity is restricted to aminoterminus.; Similarity: to other oxygen oxidoreductases that covalently bind FAD.; Title: strong similarity to 6-hydroxy-d-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 2115879; uncharacterized protein 70906 4984259 An11g00230 Aspergillus niger uncharacterized protein XP_059605429.1 69461 R 5061 CDS An11g00240 4984260 complement(join(71512..71920,72000..72074,72138..72371,72431..72642)) VII 1 NT_166526.1 Function: a novel gene that is selectively induced both in roots and shoots of Z. mays in response to sulfur starvation.; Function: its glutathione-dependent regulation indicates that maize IRL may play a crucial role in the establishment of a thiol-independent response to oxidative stress under glutathione shortage conditions.; Similarity: similarity restricted to aminoterminus.; Title: weak similarity to 2-hydroxyisoflavone reductase IRL - Zea mays; See PMID 8597660; uncharacterized protein 72642 4984260 An11g00240 Aspergillus niger uncharacterized protein XP_001394028.1 71512 R 5061 CDS An11g00250 4984263 complement(join(73251..75980,76039..84402,84439..84801,84851..85102)) VII 1 NT_166526.1 Function: lovF from A. terreus specifies formation of 2-methylbutyrate by acting as methyltransferase.; Remark: lovF is synonymous to lovastatin diketide synthase LDKS.; Similarity: similarity is confined to N-terminal half of predicted A. niger protein and lovF from A. terreus.; Title: strong similarity to lovastatin diketide synthase lovF - Aspergillus terreus; See PMID 10334994; uncharacterized protein 85102 4984263 An11g00250 Aspergillus niger uncharacterized protein XP_059605430.1 73251 R 5061 CDS An11g00260 4984232 complement(join(86303..86459,86534..86752,86806..87276,87326..87510,87560..87657,87713..87887)) VII 1 NT_166526.1 Function: in humans different MCT isoforms show specific import or export activity, depending on tissue type and substrate affinity.; Similarity: nine MCT-related sequences have so far been identified in mammals, each having a different tissue distribution, whereas six related proteins can be recognized in Caenorhabditis elegans and 4 in S. cerevisiae.; Title: strong similarity to monocarboxylate transporter MCT3 - Homo sapiens; plasma membrane; See PMID 10510291; uncharacterized protein 87887 4984232 An11g00260 Aspergillus niger uncharacterized protein XP_001394030.1 86303 R 5061 CDS An11g00270 4984247 join(88150..88446,88499..89074,89133..89708) VII 1 NT_166526.1 Function: in mammals sterol biosynthesis requires the removal of the 14 alpha-methyl group from lanosterol,this reaction is catalyzed by a microsomal cytochrome P450,the sterol 14 alpha-demethylase (P450(14DM) CYP51.; Title: strong similarity to lanosterol 14 alpha-demethylase CYP51 - Homo sapiens; See PMID 8619637; uncharacterized protein 89708 4984247 An11g00270 Aspergillus niger uncharacterized protein XP_001394031.1 88150 D 5061 CDS An11g00280 4984229 90665..91756 VII 1 NT_166526.1 Function: in Aspergillus sp. the biosynthesis of aflatoxins (B(1), G(1), B(2), and G(2)) is a multi-enzyme process controlled genetically by over 20 genes including omtB.; Function: omtB of Aspergillus sp. catalyses the conversion of demethylsterigmatocystin (DMST) to sterigmatocystin (ST) and dihydrodemethylsterigmatocystin (DHDMST) to dihydrosterigmatocystin (DHST).; Remark: aflatoxins are polyketide-derived secondary metabolites.; Title: strong similarity to O-methyltransferase omtB - Aspergillus flavus; See PMID 10328980; See PMID 10806361; uncharacterized protein 91756 4984229 An11g00280 Aspergillus niger uncharacterized protein XP_001394032.1 90665 D 5061 CDS An11g00290 4984240 complement(91966..94572) VII 1 NT_166526.1 Function: amyR from A. oryzae is a transcriptional activator involved in amylolytic gene expression.; Similarity: predicted A. niger protein contains a Zn(2)-Cys(6), fungal-type binuclear DNA-binding domain belonging to the GAL4 family of transcription factors.; Similarity: similarity to other proteins is confined to N-terminal region containing the Zn-finger domain.; Title: weak similarity to transcription regulator of maltose utilization amyR - Aspergillus oryzae; See PMID 10830498; uncharacterized protein 94572 4984240 An11g00290 Aspergillus niger uncharacterized protein XP_001394033.1 91966 R 5061 CDS An11g00300 4984253 complement(join(95094..95414,95667..95698,95774..95869,95937..96054,96111..96842)) VII 1 NT_166526.1 Catalytic activity: salicylate 1-monooxygenase from P. putida uses NADH as the external reductant and catalyzes the conversion of salicylate to catechol by introduction of a hydroxyl group in concomitant with removal of a carboxyl group.; Function: salicylate 1-monooxygenase from P. putida is an external flavoprotein monooxygenase.; Title: strong similarity to salicylate 1-monooxygenase - Pseudomonas putida; See PMID 2916843; uncharacterized protein 96842 4984253 An11g00300 Aspergillus niger uncharacterized protein XP_001394034.1 95094 R 5061 CDS An11g00310 4984236 complement(join(97998..98722,98776..99295)) VII 1 NT_166526.1 Function: C. albicans candidapepsin preferentially cleaves at the carboxyl of hydrophobic amino acids.; Title: similarity to aspartyl proteinase candidapepsin - Candida albicans; See PMID 2646602; uncharacterized protein 99295 4984236 An11g00310 Aspergillus niger uncharacterized protein XP_001394035.1 97998 R 5061 CDS An11g00320 4984250 join(99734..99907,99974..100642) VII 1 NT_166526.1 Similarity: similarity of predicted A. niger protein is confined to C-terminal region of snbDE which is much (4400 aa) longer.; Similarity: the predicted A. niger protein shows similarity to a hypothetical protein, yukK from Bacillus subtilis, with similar length (400 aa).; Title: similarity to pristinamycin I synthase 3 SnbDE - Streptomyces pristinaespiralis; See PMID 9168598; See PMID 9303382; uncharacterized protein 100642 4984250 An11g00320 Aspergillus niger uncharacterized protein XP_059605431.1 99734 D 5061 CDS An11g00330 4984239 complement(101026..101871) VII 1 NT_166526.1 Similarity: the ORF shows weak similarity to avfA from A. flavus, which participates in the biosynthesis of aflatoxin.; Title: strong similarity to hypothetical protein encoded by An07g00480 - Aspergillus niger; See PMID 10806361; uncharacterized protein 101871 4984239 An11g00330 Aspergillus niger uncharacterized protein XP_001394037.1 101026 R 5061 CDS An11g00340 84592167 complement(join(102385..102470,102566..102578,102654..102692)) VII 1 NT_166526.1 Remark: ORF judged questionable due to length below 100 aa and lack of similarities.; Title: questionable ORF; uncharacterized protein 102692 84592167 An11g00340 Aspergillus niger uncharacterized protein XP_059605432.1 102385 R 5061 CDS An11g00350 4984244 complement(join(102914..103088,103160..104284,104356..104472,104525..104733)) VII 1 NT_166526.1 Function: BBE from P. somniferum catalyzes the stereospecific conversion of the N-methyl moiety of (S)-reticuline into the berberine bridge carbon of (S)-scoulerine and represents the first committed step in the pathway leading to the antimicrobial alkaloid sanguinarine.; Title: strong similarity to berberine bridge enzyme BBE - Papaver somniferum; endosome; See PMID 8972604; uncharacterized protein 104733 4984244 An11g00350 Aspergillus niger uncharacterized protein XP_001394039.1 102914 R 5061 CDS An11g00360 84592168 join(106831..107101,107165..107211,107401..107442,107838..108056) VII 1 NT_166526.1 Function: chimpanzee EDN is a host defense protein that is a member of the mammalian ribonuclease gene family.; Similarity: only N-terminal half of predicted A. niger protein shows similarity to chimpanzee EDN.; Title: weak similarity to eosinophil cationic protein ECP - Pan troglodytes; See PMID 7663519; uncharacterized protein 108056 84592168 An11g00360 Aspergillus niger uncharacterized protein XP_059605433.1 106831 D 5061 CDS An11g00370 4984241 join(108108..108237,108308..108392,108484..108595,108690..109654,109708..110121,110222..110415,110497..110598,110653..110834) VII 1 NT_166526.1 Function: FacB from A. niger is a major regulatory gene involved in acetamide and acetate utilisation.; Remark: FacB is synonymous to AcuB.; Similarity: FacB from A. nidulans contains an N-terminal GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster for DNA binding, leucine zipper-like heptad repeat motifs and central and C-terminal acidic alpha-helical regions.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus niger; See PMID 9197408; See PMID 10483720; uncharacterized protein 110834 4984241 An11g00370 Aspergillus niger uncharacterized protein XP_059605434.1 108108 D 5061 CDS An11g00380 4984265 complement(join(111153..111317,111367..112428,112489..112806)) VII 1 NT_166526.1 Function: in S. cerevisiae YAP1 transcriptionally regulated diazaborine resistance requires the efflux pump Flr1p, which is located in the cytoplasmic membrane.; Similarity: Flr1 from S. cerevisiae belongs to the major-facilitator-superfamily.; Similarity: the ORF shows similarity to several multi-drug resistance transporters (MDR).; Title: strong similarity to fluconazole resistance transporter Flr1 - Saccharomyces cerevisiae; plasma membrane; See PMID 10903515; uncharacterized protein 112806 4984265 An11g00380 Aspergillus niger uncharacterized protein XP_059605435.1 111153 R 5061 CDS An11g00390 4984257 join(114216..114879,114942..115033,115099..115113,115169..116349,116610..116778) VII 1 NT_166526.1 Function: rhiE from E. chrysanthemi has rhamnogalacturonate lyase activity on rhamnogalacturonan I.; Remark: rhiE from E. chrysanthemi is secreted through the type II Out secretion pathway.; Title: similarity to rhamnogalacturonase rhiE -Erwinia chrysanthemi; uncharacterized protein 116778 4984257 An11g00390 Aspergillus niger uncharacterized protein XP_001394043.3 114216 D 5061 CDS An11g00400 4984266 join(117253..117856,117916..118141,118198..118566,118614..118950) VII 1 NT_166526.1 Catalytic activity: human IVD catalyzes the conversion of isovaleryl-CoA to 3-methylcrotonyl-CoA.; Complex: human IVD is a homotetrameric, FAD-binding enzyme.; Function: human IVD catalyzes the third step in the catabolism of leucine.; Localization: human IVD is a nuclear-encoded,mitochondrial protein.; Remark: deficiency of human IVD leads to the clinical disorder isovaleric acidemia.; Similarity: the ORF shows similarity to several acyl-CoA dehydrogenases.; Title: similarity to isovaleryl-CoA dehydrogenase IVD - Homo sapiens; localisation:mitochondrion; See PMID 10713113; uncharacterized protein 118950 4984266 An11g00400 Aspergillus niger uncharacterized protein XP_001394044.1 117253 D 5061 CDS An11g00410 4984267 join(119881..120067,120133..121034) VII 1 NT_166526.1 Similarity: similarity to SPAC15E1. 10 from S. pombe is between the C-terminal regions.; Similarity: the predicte A. niger protein shows unspecific similarity to glycine rich proteins.; Title: similarity to hypothetical protein SPAC15E1.10 - Schizosaccharomyces pombe; uncharacterized protein 121034 4984267 An11g00410 Aspergillus niger uncharacterized protein XP_001394045.1 119881 D 5061 CDS An11g00420 4984268 join(121867..122028,122110..122151,122267..122372,122438..122971,123045..123117,123176..123248) VII 1 NT_166526.1 Function: PP2A appears to be the major kinase phosphatase in eukaryotic cells that downregulates activated protein kinases.; Function: protein phosphatase 2A is involved in hyphal growth of Neurospora crassa.; Title: strong similarity to serine/threonine specific phosphoprotein phosphatase type 2A catalytic chain PP2A - Neurospora crassa; cytoplasm; See PMID 9790584; See PMID 10322434; uncharacterized protein 123248 4984268 An11g00420 Aspergillus niger uncharacterized protein XP_001394046.1 121867 D 5061 CDS An11g00430 4984269 complement(join(124033..124292,124362..124484,124542..124704,124766..125347,125423..125597,125659..125723)) VII 1 NT_166526.1 Function: human HGO cleaves the aromatic ring during the metabolic degradation of Phe and Tyr.; Function: mutations in human HGO lead to Alkaptonuria, a rare hereditary disorder of the phenylalanine catabolism.; Title: strong similarity to homogentisate 1,2-dioxygenase HGO - Homo sapiens; See PMID 9244427; uncharacterized protein 125723 4984269 An11g00430 Aspergillus niger uncharacterized protein XP_059605436.1 124033 R 5061 CDS An11g00440 4984270 complement(join(126557..127135,127191..127532,127585..127766,127820..127867,127932..128101,128169..128353)) VII 1 NT_166526.1 Catalytic activity: lipases catalyse the reaction,Triacylglycerol + H(2)O <=> diacylglycerol + a fatty acid anion.; Localization: In addition no extracellular lipase activity was detected with the lip2 knockout (KO) strain,strongly suggesting that extracellular lipase activity results only from expression of the LIP2 gene.; Localization: lip1 from Y. lipolytica is probably an intracellular or cell-bound lipase, because no clear signal sequence was identified.; Title: strong similarity to triacylglycerol lipase Lip1 - Yarrowia lipolytica; See PMID 10781549; uncharacterized protein 128353 4984270 An11g00440 Aspergillus niger uncharacterized protein XP_001394048.1 126557 R 5061 CDS An11g00450 4984271 complement(join(129061..129776,129888..130304,130366..130425,130497..130554,130630..130650,130729..130848)) VII 1 NT_166526.1 Remark: the tetH gene is encoded on plasmid pVM111 of P. multocida.; Similarity: the ORF shows similarity to several amine transporters and tetracycline resistance proteins.; Title: strong similarity to tetracycline resistance protein tetH - Pasteurella multocida; uncharacterized protein 130848 4984271 An11g00450 Aspergillus niger uncharacterized protein XP_059605437.1 129061 R 5061 CDS An11g00460 4984272 complement(join(131312..132625,132677..133051)) VII 1 NT_166526.1 Complex: human APP-BP1 binds to the amyloid precursor protein (APP) carboxyl-terminal domain and interacts with hUba3.; Function: Recent work suggests that human APP-BP1 participates in a novel ubiquitinylation-related pathway involving the ubiquitin-like molecule NEDD8.; Function: expression of human APP-BP1 in ts41 cells drives the cell cycle through the S-M checkpoint and this function requires both hUba3 and hUbc12.; Function: human APP-BP1 together with hUba3 behaves like the ubiquitin activating enzyme E1, with hUba3 containing the active cysteine and ATP binding site.; Title: strong similarity to amyloid precursor protein-binding protein 1 APP-B1 - Homo sapiens; nucleus; See PMID 10722740; See PMID 11027288; uncharacterized protein 133051 4984272 An11g00460 Aspergillus niger uncharacterized protein XP_059605438.1 131312 R 5061 CDS An11g00470 4984273 join(133806..134184,134262..134704) VII 1 NT_166526.1 Catalytic activity: RPIs catalyse the reaction,D-ribose 5-phosphate <=> D-ribulose 5-phosphate.; Function: RPI from M. musculus takes part in the pentose phosphate pathway.; Title: strong similarity to ribose 5-phosphate isomerase RPI - Mus musculus; cytoplasm; See PMID 7758956; See PMID 2843500; uncharacterized protein 134704 4984273 An11g00470 Aspergillus niger uncharacterized protein XP_001394051.1 133806 D 5061 CDS An11g00480 4984274 complement(join(134941..135739,135818..136079,136125..136134)) VII 1 NT_166526.1 Function: sldA from A. nidulans take part in mitotic cycle control.; Title: strong similarity to spindle assembly checkpoint protein sldA - Aspergillus nidulans; nucleus; See PMID 9584089; See PMID 10723032; uncharacterized protein 136134 4984274 An11g00480 Aspergillus niger uncharacterized protein XP_059605439.1 134941 R 5061 CDS An11g00490 4984275 join(136333..136621,136687..136787,136853..137521) VII 1 NT_166526.1 Function: S. pombe Fet5 heterospecific complementates a conditional mutant of S. cerevisiae defective in the function of the RNA polymerases I-III common subunit ABC10 beta.; Function: features of the S. pombe Fet5 amino acid sequence suggest that it belongs to ATP/GTP-binding proteins.; Title: similarity to purine nucleotide binding protein fet5p - Schizosaccharomyces pombe; See PMID 9190794; uncharacterized protein 137521 4984275 An11g00490 Aspergillus niger uncharacterized protein XP_001394053.1 136333 D 5061 CDS An11g00500 4984276 complement(join(137687..138051,138154..138412)) VII 1 NT_166526.1 Complex: POP5 from S. cerevisiae is an integral subunit of RNase P and apparent subunit of RNase MRP.; Function: RNase MRP has been suggested to be involved in the processing of precursor rRNA; RNase P, in the maturation of tRNA.; Localization: RNase MRP/P have activity in both the nucleus and the mitochondria.; Remark: information concerning S. cerevisiae POP5 is drawn from http://genome-www4. stanford. edu/cgi-bin/SGD/locus. pl?locus=POP5 and as of 24/1/01/ not yet available in published form.; Similarity: FUN53 is synonymous to POP5.; Similarity: Processing Of Precursors - refer to a group of proteins that appear to be components of both RNase P and RNase MRP.; Title: strong similarity to Pop5 - Saccharomyces cerevisiae; nucleus; See PMID 8901493; uncharacterized protein 138412 4984276 An11g00500 Aspergillus niger uncharacterized protein XP_001394054.1 137687 R 5061 CDS An11g00510 4984277 complement(join(139058..139485,139544..140639,140693..140882,140935..141051,141106..141245)) VII 1 NT_166526.1 Catalytic activity: ACLs catalyse the reaction, ATP + citrate + CoA <=> ADP + phosphate + acetyl-CoA + oxaloacetate.; Function: mutants of S. macrospora ACL1 exhibit a sterile phenotype with defects in fruiting body maturation.; Title: strong similarity to ATP citrate lyase ACL1 -Sordaria macrospora; cytoplasm; See PMID 9858569; uncharacterized protein 141245 4984277 An11g00510 Aspergillus niger uncharacterized protein XP_001394055.1 139058 R 5061 CDS An11g00520 84592169 join(142003..142095,142193..142198,142331..142673,142833..142918,143187..143525) VII 1 NT_166526.1 hypothetical protein 143525 84592169 An11g00520 Aspergillus niger hypothetical protein XP_059605440.1 142003 D 5061 CDS An11g00530 4984279 join(143932..144372,144452..145468) VII 1 NT_166526.1 Catalytic activity: ACLs catalyse the reaction, ATP + citrate + CoA <=> ADP + phosphate + acetyl-CoA + oxaloacetate.; Title: strong similarity to ATP citrate lyase - Homo sapiens; localisation:mitochondrion; See PMID 1371749; uncharacterized protein 145468 4984279 An11g00530 Aspergillus niger uncharacterized protein XP_001394057.1 143932 D 5061 CDS An11g00540 84592170 join(147087..147125,147250..147321,147435..147495,147533..147620,147769..147919) VII 1 NT_166526.1 Title: weak similarity to hypothetical protein F18O22.300 - Arabidopsis thaliana; uncharacterized protein 147919 84592170 An11g00540 Aspergillus niger uncharacterized protein XP_059605441.1 147087 D 5061 CDS An11g00550 84592171 complement(join(148267..148413,148528..148752,148902..148904)) VII 1 NT_166526.1 Complex: In the presence of ADP, one molecule of S. cerevisiae hsp10 binds to hsp60 with an apparent Kd of 0. 9 nM and a second molecule of hsp10 binds with a Kd of 24 nM.; Function: In the presence of ATP, the purified S. cerevisiae chaperonins mediate the refolding of mitochondrial malate dehydrogenase.; Function: S. cerevisiae hsp10 inhibits the ATPase activity of hsp60 by about 40%.; Title: strong similarity to chaperonin Hsp10 -Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9067800; See PMID 9256426; uncharacterized protein 148904 84592171 An11g00550 Aspergillus niger uncharacterized protein XP_059605442.1 148267 R 5061 CDS An11g00560 4984281 complement(join(149454..150216,150270..150322,150378..150533)) VII 1 NT_166526.1 Complex: Coimmunoprecipitation experiments with S. cerevisiae proteins reveal that RNA14, a subunit of cleavage factor I (CF I), directly interacts with FIP1, but not with PAP1.; Complex: S. cerevisiae FIP1 interacts with poly(A) polymerase (PAP1) in the two-hybrid assay.; Function: Coimmunoprecipitation experiments with S. cerevisiae suggest a model in which Fip1 tethers PAP1 to CF I, thereby conferring specificity to poly(A) polymerase for pre-mRNA substrates.; Title: similarity to pre-mRNA polyadenylation factor Fip1 - Saccharomyces cerevisiae; nucleus; See PMID 7736590; uncharacterized protein 150533 4984281 An11g00560 Aspergillus niger uncharacterized protein XP_001394060.3 149454 R 5061 CDS An11g00570 4984283 join(150931..151163,151222..151663,151709..151792,151840..152154) VII 1 NT_166526.1 Title: strong similarity to hypothetical xap-5-like protein - Schizosaccharomyces pombe; uncharacterized protein 152154 4984283 An11g00570 Aspergillus niger uncharacterized protein XP_059605443.1 150931 D 5061 CDS An11g00580 4984284 join(152435..152507,152644..152827,152880..153016,153059..153472,153527..153783) VII 1 NT_166526.1 Similarity: human DKFZp564A0772. 1 is 80 aa shorter than the predicted A. niger protein. .; Title: similarity to hypothetical protein DKFZp564A0772.1 - Homo sapiens; uncharacterized protein 153783 4984284 An11g00580 Aspergillus niger uncharacterized protein XP_059605444.1 152435 D 5061 CDS An11g00590 10098067 complement(join(154540..156213,156271..156903)) VII 1 NT_166526.1 Function: TmGRF from T. melitor belongs to the GCNF1 family and its in vitro translated product binds to the extended half site TCAAGGTCA with high affinity.; Similarity: similarity is from central part of predicted A. niger protein to N-terminus of TmGRF from T. melitor.; Title: weak similarity to nuclear hormone receptor TmGRF - Tenebrio molitor; See PMID 10518792; uncharacterized protein 156903 10098067 An11g00590 Aspergillus niger uncharacterized protein XP_059605445.1 154540 R 5061 CDS An11g00600 4984286 complement(join(157223..157402,157456..157896,157951..158070,158128..158577)) VII 1 NT_166526.1 Catalytic activity: TauD from E. coli converts taurine to sulfite and aminoacetaldehyde.; Function: tauD of E. coli is required for the utilization of taurine (2-aminoethanesulfonic acid) as a sulfur source and is expressed only under conditions of sulfate starvation.; Remark: EC 1. 14. 11. 17 (not in EC number catalogue).; Remark: among the cosubstrates tested for E. coli TauD, only alpha-ketoglutarate (Km = 11 microM) supported significant dioxygenase activity.; Remark: taurine (Km = 55 microM) was the preferred substrate of E. coli TauD, but pentanesulfonic acid,3-(N-morpholino)propanesulfonic acid, and 1,3-dioxo-2-isoindolineethanesulfonic acid were also desulfonated at significant rates.; Similarity: tauD from E. coli is a member of the alpha-ketoglutarate-dependent dioxygenase family.; Title: strong similarity to taurine dioxygenase tauD - Escherichia coli; See PMID 9287300; uncharacterized protein 158577 4984286 An11g00600 Aspergillus niger uncharacterized protein XP_001394064.1 157223 R 5061 CDS An11g00610 4984287 complement(join(159962..160895,160950..161351,161537..161607)) VII 1 NT_166526.1 Similarity: S. cerevisiea NUP49 belongs to the GLGF family of nucleoporins.; Title: strong similarity to nuclear pore complex subunit Nup49 - Saccharomyces cerevisiae; nucleus; See PMID 10684247; uncharacterized protein 161607 4984287 An11g00610 Aspergillus niger uncharacterized protein XP_059605446.1 159962 R 5061 CDS An11g00620 4984288 join(162303..162478,162528..162590,162644..163512,163567..163742) VII 1 NT_166526.1 Title: similarity to guanine nucleotide-binding protein beta 5 Gnb5 - Mesocricetus auratus; See PMID 7613025; uncharacterized protein 163742 4984288 An11g00620 Aspergillus niger uncharacterized protein XP_001394066.1 162303 D 5061 CDS An11g00630 4984289 join(164041..164155,164342..164422,164814..164895,164958..166680,166737..166830,166891..167732) VII 1 NT_166526.1 Function: in D. discoideum DhkA functions both in the regulation of prestalk gene expression and in the control of the terminal differentiation of prespore cells.; Function: in D. discoideum SDF-2 peptide, released by prestalk cells during culmination, stimulates prespore cells to encapsulate by binding to the DhkA transmembrane receptor.; Pathway: in D. discoideum suppressor studies indicate that the cyclic AMP (cAMP) phosphodiesterase RegA and the cAMP-dependent protein kinase PKA act downstream of DhkA.; Remark: central part of predicted A. niger protein shows putatively unspecific similarity to asparagine rich proteins.; Remark: similarity of predicted A. niger protein to DhkA of D. discoideum is not restricted to asparagine repeats.; Title: similarity to sensory transduction histidine kinase dhkA - Dictyostelium discoideum; plasma membrane; See PMID 8670894; See PMID 9191038; See PMID 10373524; uncharacterized protein 167732 4984289 An11g00630 Aspergillus niger uncharacterized protein XP_059605447.1 164041 D 5061 CDS An11g00640 4984290 complement(join(168842..169540,169682..169841,169895..169914)) VII 1 NT_166526.1 Catalytic activity: L. lactis pgmB catalyses the conversion of beta-glucose 1-phosphate to glucose 6-phosphate.; Similarity: the ORF shows similarity to haloacid dehalogenase-like hydrolases from several species (GS1-like proteins of the CBBY/CBBZ/GPH/YIEH family).; Title: similarity to phosphoglucomutase pgmB -Lactococcus lactis; See PMID 9084169; uncharacterized protein 169914 4984290 An11g00640 Aspergillus niger uncharacterized protein XP_001394068.1 168842 R 5061 CDS An11g00650 4984291 join(170185..170286,170347..170970,171021..171122) VII 1 NT_166526.1 Remark: human tpr1 interacts in a two-hybrid screen with the GAP-related domain of neurofibromin, the product of the NF1 gene.; Title: strong similarity to tetratricopeptide repeat protein tpr1 - Homo sapiens; See PMID 8836031; uncharacterized protein 171122 4984291 An11g00650 Aspergillus niger uncharacterized protein XP_001394069.1 170185 D 5061 CDS An11g00660 4984292 join(171462..171778,171900..172133,172190..172365,172418..172779,172838..173440,173491..173753,173799..174567) VII 1 NT_166526.1 Catalytic activity: B. subtilis pnbA catalyzes hydrolysis of several beta-lactam antibiotic PNB esters to the corresponding free acid and PNB alcohol.; Similarity: the ORF shows additionally strong similarity to several triacylglycerol lipases from different species.; Title: strong similarity to p-nitrobenzyl esterase pnbA - Bacillus subtilis; See PMID 7828905; uncharacterized protein 174567 4984292 An11g00660 Aspergillus niger uncharacterized protein XP_059605448.1 171462 D 5061 CDS An11g00670 4984293 complement(join(174938..176345,176398..176675,176726..176791,176878..177018)) VII 1 NT_166526.1 Function: in human cell culture cathepsin D was identified as the first endosomal ceramide target that colocalizes with and may mediate downstream signaling effects of A-SMase.; Function: murine ASM is reported to have an essential function in stress-induced apoptosis and in CD95-induced apoptosis.; Remark: murine ASM is a lysosomal glycoprotein.; Title: strong similarity to acidic sphingomyelin phosphodiesterase ASM - Mus musculus; lysosome; See PMID 8943261; See PMID 10508159; See PMID 10867001; See PMID 11001565; uncharacterized protein 177018 4984293 An11g00670 Aspergillus niger uncharacterized protein XP_001394071.1 174938 R 5061 CDS An11g00680 4984294 complement(join(178655..178848,178920..179566,179637..179987,180048..180411,180469..180626,180679..181375,181440..181560)) VII 1 NT_166526.1 Catalytic activity: SGTs can use different sterols such as cholesterol, sitosterol, and ergosterol as sugar acceptors.; Function: Microorganisms containing a recombinant SGT protein have better resistance to high salt/ethanol content of growth media, cold/frost and high temperature.; Function: Sterol glucosides, typical membrane-bound lipids, are biosynthesized by a UDP-glucose:sterol glucosyltransferase.; Remark: literature for SGT from A. sativa is Patent WO9817789.; Similarity: no similarity to C-terminal 300 aa of predicted A. niger protein was found.; Title: similarity to sterol glycosyltransferase SGT - Avena sativa; See PMID 10224056; uncharacterized protein 181560 4984294 An11g00680 Aspergillus niger uncharacterized protein XP_059605449.1 178655 R 5061 CDS An11g00690 4984295 join(182576..183010,183072..185525) VII 1 NT_166526.1 Similarity: N-terminus of predicted A. niger protein shows similarity to viral anti-apoptotic peptides.; Similarity: only N- and C-terminal 100 aa of predicted A. niger protein show similarity to N- and C-terminus of S. cerevisiae YNL008c.; Title: similarity to hypothetical ubiquitin protein ligase Asi3 - Saccharomyces cerevisiae; uncharacterized protein 185525 4984295 An11g00690 Aspergillus niger uncharacterized protein XP_001394073.1 182576 D 5061 CDS An11g00700 84592172 join(186424..186961,187028..187254) VII 1 NT_166526.1 Similarity: predicted A. niger protein shows unspecific similarity to serine rich proteins.; Title: weak similarity to mucin PGM-B - Sus scrofa; See PMID 7755593; uncharacterized protein 187254 84592172 An11g00700 Aspergillus niger uncharacterized protein XP_059605450.1 186424 D 5061 CDS An11g00710 4984297 complement(join(188103..188503,188555..188693,188754..188834)) VII 1 NT_166526.1 Title: strong similarity to immunoreactive Antigen 2 Ag2 - Coccidioides immitis; plasma membrane; See PMID 8973319; uncharacterized protein 188834 4984297 An11g00710 Aspergillus niger uncharacterized protein XP_001394075.1 188103 R 5061 CDS An11g00720 4984298 complement(join(190217..190360,190421..190488,190549..190930)) VII 1 NT_166526.1 Complex: in S. pombe the pol delta complex consists of five subunits.; Title: similarity to DNA-directed DNA polymerase delta chain cdm1p - Schizosaccharomyces pombe; See PMID 9326594; uncharacterized protein 190930 4984298 An11g00720 Aspergillus niger uncharacterized protein XP_001394076.1 190217 R 5061 CDS An11g00730 4984299 join(192852..192893,192954..193142) VII 1 NT_166526.1 Similarity: hypothetical protein contains domains with similarity to cGMP-gated ion channel proteins.; hypothetical protein 193142 4984299 An11g00730 Aspergillus niger hypothetical protein XP_001394077.1 192852 D 5061 CDS An11g00740 4984300 complement(join(194011..194253,194309..195193,195256..195333)) VII 1 NT_166526.1 Similarity: SPBC19G7. 08c of S. pombe is N-terminally approx. 100 amino acids longer.; Title: similarity to hypothetical protein SPBC19G7.08c - Schizosaccharomyces pombe; uncharacterized protein 195333 4984300 An11g00740 Aspergillus niger uncharacterized protein XP_001394078.1 194011 R 5061 CDS An11g00742 10098229 join(197181..197562,197650..197690,197751..197894) VII 1 NT_166526.1 Function: In over-expression of cdm1 is able to rescue cells carrying temperature-sensitive mutations in either pol3+/cdc6+, cdc1+ or cdc27+.; Function: S. pombe cCells deleted for cdm1+ are viable.; Function: cdm1 from S. pombe encodes the smallest (22kDa) subunit of the DNA polymerase delta complex.; Title: similarity to DNA-directed DNA polymerase delta chain cdm1p - Schizosaccharomyces pombe; nucleus; See PMID 9799358; uncharacterized protein 197894 10098229 An11g00742 Aspergillus niger uncharacterized protein XP_059601521.1 197181 D 5061 CDS An11g00744 10098230 join(199277..199357,199418..200008) VII 1 NT_166526.1 Remark: Ag2 from C. immitis encodes an immunoreactive protein.; Remark: Ag2 from C. immitis is a glycosylated protein present in the cell walls.; Title: similarity to immunoreactive protein precursor Ag2 - Coccidioides immitis; cell wall; See PMID 8561782; See PMID 8973319; uncharacterized protein 200008 10098230 An11g00744 Aspergillus niger uncharacterized protein XP_059601522.1 199277 D 5061 CDS An11g00746 84592173 complement(join(200324..200688,201117..201822,201992..202036)) VII 1 NT_166526.1 hypothetical protein 202036 84592173 An11g00746 Aspergillus niger hypothetical protein XP_059601523.1 200324 R 5061 CDS An11g00748 10098068 complement(202586..>203872) VII 1 NT_166526.1 Remark: the ORF is N-terminally truncated due to border of contig.; Remark: the similarities to the different ubiquitin-protein ligases is restricted to the very C-terminus.; Remark: ubiquitin-protein ligases of the class III only share C-terminal sequence similarities.; Title: weak similarity to ubiquitin protein ligase Asi3 - Saccharomyces cerevisiae [truncated ORF]; uncharacterized protein 203872 10098068 An11g00748 Aspergillus niger uncharacterized protein XP_003188833.2 202586 R 5061 CDS An11g00750 4984305 join(204222..204337,204423..204601,204674..205192,205243..205688) VII 1 NT_166526.1 Catalytic activity: endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron.; Complex: heterotetramer composed of SEN2, SEN15,SEN34 and SEN54.; Complex: this subunit interacts with SEN2.; Function: SEN54 of S. cerevisiae cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini.; Function: SEN54 of S. cerevisiae encodes one of the catalytic subunits of the tRNA-splicing endonuclease which is responsible for identification and cleavage of the splice sites in pre-tRNA.; Remark: YPL083c is synonymous to SEN54.; Remark: there are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.; Title: similarity to tRNA-splicing endonuclease subunit Sen54 - Saccharomyces cerevisiae; See PMID 9200603; uncharacterized protein 205688 4984305 An11g00750 Aspergillus niger uncharacterized protein XP_059601524.1 204222 D 5061 CDS An11g00760 4984306 join(207097..207561,207632..208034,208144..208263,208364..208410) VII 1 NT_166526.1 Pathway: fabG of B. subtilis is involved in phospholipid synthesis.; Remark: fabG of B. subtilis exhibits a marked preference for acyl-carrier-protein derivatives over CoA derivatives as substrates.; Similarity: closest manual homologue (BLASTP): PIRNEW:T46633 3-oxoacyl-[acyl-carrier-protein] reductase fabG - Bacillus subtilis.; Similarity: data bank entries are N- and C-terminally shorter than this protein.; Title: strong similarity to 3-oxoacyl-(acyl-carrier-protein) reductase fabG - Bacillus subtilis; See PMID 8759840; uncharacterized protein 208410 4984306 An11g00760 Aspergillus niger uncharacterized protein XP_001394084.3 207097 D 5061 CDS An11g00770 4984307 complement(join(208706..209895,209943..210007,210057..210181,210249..210485,210587..210757,210868..210927)) VII 1 NT_166526.1 Function: in vitro, recombinant SAE1/SAE2 (SUMO-1-activating enzyme) catalyzes the ATP-dependent formation of a thioester linkage between SUMO-1 and SAE2.; Remark: SUMO-1 is a small ubiquitin-related modifier that is covalently linked to many cellular protein targets.; Remark: modification by SUMO-1 is proposed to play a role in protein targeting and/or stability.; Title: strong similarity to SUMO-1 activating enzyme subunit 2 SAE2 - Homo sapiens; See PMID 10187858; uncharacterized protein 210927 4984307 An11g00770 Aspergillus niger uncharacterized protein XP_001394085.1 208706 R 5061 CDS An11g00780 4984308 join(213149..213563,213618..213772,213835..214066,214128..214555) VII 1 NT_166526.1 Remark: based on the hypothetical protein B2A19. 160 an additional intron could be introduced.; Title: strong similarity to hypothetical protein B2A19.160 - Neurospora crassa; uncharacterized protein 214555 4984308 An11g00780 Aspergillus niger uncharacterized protein XP_001394086.1 213149 D 5061 CDS An11g00790 4984309 complement(join(214890..216135,216166..216350)) VII 1 NT_166526.1 Similarity: a similarity exists only at the N-terminal sequence.; Title: strong similarity to hypothetical protein EAA64158.1 - Aspergillus nidulans; uncharacterized protein 216350 4984309 An11g00790 Aspergillus niger uncharacterized protein XP_059601525.1 214890 R 5061 CDS An11g00800 4984310 join(216671..216682,216751..216816,216892..217449) VII 1 NT_166526.1 Catalytic activity: cyp-4 of C. elegans catalyzed the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.; Function: cyp-4 of C. elegans catalyses one step in the refolding of urea-denatured ribonuclease A. The enzyme is identical with the protein which binds the immunosuppressive drug cyclosporin; Remark: cyp-4 of C. elegans is a cis-trans-Isomerase.; Similarity: cyp-4 of C. elegans belongs to the cyclophilin-type PPIase family.; Title: similarity to peptidyl-prolyl cis-trans isomerase 4 cyp-4 - Caenorhabditis elegans; See PMID 8694762; See PMID 10228556; See PMID 10424896; uncharacterized protein 217449 4984310 An11g00800 Aspergillus niger uncharacterized protein XP_001394088.1 216671 D 5061 CDS An11g00810 4984311 complement(join(220777..221349,221442..221993,222049..222688,222746..222874,222934..222983)) VII 1 NT_166526.1 Function: PUT3 of S. cerevisiae binds to DNA sequences in the promoters of the proline utilization genes and is required for the basal and induced expression of the enzymes of this pathway.; Title: similarity to transcription activator Put3 -Saccharomyces cerevisiae; See PMID 2017167; uncharacterized protein 222983 4984311 An11g00810 Aspergillus niger uncharacterized protein XP_059601526.1 220777 R 5061 CDS An11g00820 84592174 join(223396..223432,223676..223998) VII 1 NT_166526.1 hypothetical protein 223998 84592174 An11g00820 Aspergillus niger hypothetical protein XP_059601527.1 223396 D 5061 CDS An11g00830 4984313 join(224952..225565,225613..228412) VII 1 NT_166526.1 Title: similarity to hypothetical protein B2O8.180 -Neurospora crassa; uncharacterized protein 228412 4984313 An11g00830 Aspergillus niger uncharacterized protein XP_001394091.3 224952 D 5061 CDS An11g00840 4984314 complement(join(228952..229521,230359..230955,231013..231114,231180..231233)) VII 1 NT_166526.1 Catalytic activity: DBR1 hydrolyzes the 2'-5' phosphodiester linkage at the branchpoint of excised intron lariats.; Function: DBR1 is a debranching enzyme with a RNA processing activity that cleaves the branchpoint of excised intron lariats.; Remark: based on sequence similarities an unusually large intron was introduced in this ORF during the gene modelling process.; Remark: none of the gene modelling programs predicted an intron at this position, therefore the occurence of this big intron might be questionable.; Title: strong similarity to RNA lariat debranching enzyme hDBR1 - Homo sapiens; See PMID 10982890; uncharacterized protein 231233 4984314 An11g00840 Aspergillus niger uncharacterized protein XP_059601528.1 228952 R 5061 CDS An11g00850 84592175 231922..232023 VII 1 NT_166526.1 Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 232023 84592175 An11g00850 Aspergillus niger uncharacterized protein XP_059606301.1 231922 D 5061 CDS An11g00860 4984316 join(232504..233030,233151..234855,234916..235254,235313..235729) VII 1 NT_166526.1 Complex: rat TIP120 binds to TATA-binding protein (TBP) and to RPB5, one of the common subunits of the eukaryotic RNA polymerases.; Function: rat TIP120 activates the basal level of transcription from various kinds of promoters and also stimulates RNAP I- and III-driven transcription.; Function: rat TIP120 functions during preinitiation complex (PIC) formation at the step of RNAP II/TFIIF recruitment to the promoter.; Function: rat TIP120 interacts with TBP wich is a central component for transcriptional regulation.; Localization: rat TIP120 was isolated from nuclear extracts.; Title: strong similarity to TATA-Binding protein-interacting protein TIP120 - Rattus norvegicus; nucleus; See PMID 10567521; uncharacterized protein 235729 4984316 An11g00860 Aspergillus niger uncharacterized protein XP_059606302.1 232504 D 5061 CDS An11g00870 4984317 complement(join(236276..237425,237478..241913)) VII 1 NT_166526.1 Remark: the similarity to CAD21060. 1 from N. crassa is restricted to the N-terminal half.; Remark: the similarity to other proteins is mainly based on repetetive structures.; Title: similarity to hypothetical protein CAD21060.1 - Neurospora crassa; uncharacterized protein 241913 4984317 An11g00870 Aspergillus niger uncharacterized protein XP_059606303.1 236276 R 5061 CDS An11g00880 84592176 complement(join(242436..242570,242744..242836)) VII 1 NT_166526.1 Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 242836 84592176 An11g00880 Aspergillus niger uncharacterized protein XP_059606304.1 242436 R 5061 CDS An11g00890 4984319 complement(join(244054..244233,244318..244564,244636..244787)) VII 1 NT_166526.1 hypothetical protein 244787 4984319 An11g00890 Aspergillus niger hypothetical protein XP_001394097.1 244054 R 5061 CDS An11g00900 84592177 complement(join(245011..245052,245097..245249,245343..245498)) VII 1 NT_166526.1 Similarity: Remark: blastp shows significant similarity (42% identity) between predicted A. niger protein and R. prowazekii addA but due to shortness of both peptides the probability is low (p=4,4).; Title: similarity to hypothetical erythrocyte adducin alpha chain addA - Rickettsia prowazekii; uncharacterized protein 245498 84592177 An11g00900 Aspergillus niger uncharacterized protein XP_059606305.1 245011 R 5061 CDS An11g00910 4984321 join(245685..245914,245977..246661) VII 1 NT_166526.1 Function: Deletion analysis demonstrated that a 412-residue N-terminal domain, which includes an acidic region and the TBP-binding domain, is required for R. norvegicus TIP120 function.; Function: R. norvegicus TIP120 activates the basal level of transcription from various kinds of promoters regardless of the template DNA topology and the presence of TFIIE/TFIIH and TBP-associated factors.; Function: R. norvegicus TIP120 also stimulates RNAP I- and III-driven transcription.; Similarity: similarity is from predicted A. niger protein to N-terminus of R. norvegicus TIP120, which is 900 aa longer.; Title: similarity to TATA-Binding protein-interacting protein TIP120 - Rattus norvegicus; nucleus; See PMID 10567521; See PMID 8954946; uncharacterized protein 246661 4984321 An11g00910 Aspergillus niger uncharacterized protein XP_001394099.1 245685 D 5061 CDS An11g00920 4984322 join(247323..247539,247594..248756) VII 1 NT_166526.1 Function: Pneumococci in which pgdA was inactivated produced fully N-acetylated glycan and became hypersensitive to exogenous lysozyme in the stationary phase of growth.; Title: similarity to peptidoglycan GlcNAc deacetylase PgdA - Streptococcus pneumoniae; See PMID 10781617; uncharacterized protein 248756 4984322 An11g00920 Aspergillus niger uncharacterized protein XP_001394100.1 247323 D 5061 CDS An11g00930 4984323 complement(join(249242..250908,251079..251187)) VII 1 NT_166526.1 Title: similarity to hypothetical protein EAA64167.1 - Aspergillus nidulans; uncharacterized protein 251187 4984323 An11g00930 Aspergillus niger uncharacterized protein XP_001394101.3 249242 R 5061 CDS An11g00940 4984324 complement(join(251465..251842,251892..252290,252343..252843,252896..253231,253284..253517,253565..254161,254264..254560,254765..254779)) VII 1 NT_166526.1 Complex: S. cerevisiae Pep3p and Pep5p associate physically with Pep7p as revealed by two-hybrid analysis.; Function: S. cerevisiae PEP5 is required for vacuole biogenesis and maintenance of the vacuole structure itself, for gluconeogenic growth and mating response in S. cerevisiae.; Function: in S. cerevisiae a core Pep3p/Pep5p complex putatively promotes vesicular docking/fusion reactions in conjunction with SNARE proteins at multiple steps in transport routes to the vacuole and might be responsible for tethering transport vesicles on target membranes.; Remark: alternative names for S. cerevisiae PEP5 are END1, VAM1, VPL9, VPS11, VPT11 and YMR231W.; Title: strong similarity to vacuolar biogenesis protein Pep5 - Saccharomyces cerevisiae; vacuole; See PMID 10978279; See PMID 2670552; See PMID 2676511; uncharacterized protein 254779 4984324 An11g00940 Aspergillus niger uncharacterized protein XP_059606306.1 251465 R 5061 CDS An11g00950 84592178 join(255167..255504,255658..255881,256029..256258,256310..256478,256565..256740) VII 1 NT_166526.1 Function: N. tabacum PK12 phosphorylates and physically interacts with serine/arginine-rich (SR) splicing factors in vivo to alter their activity and the splicing of target mRNAs.; Induction: tobacco PK12 is induced by the plant hormone ethylene.; Similarity: N. tabacum PK12 is a member of the LAMMER family of protein kinases.; Title: similarity to protein kinase PK12 - Nicotiana tabacum; deleted EC_number 2.7.1.37; See PMID 8989879; See PMID 10652154; uncharacterized protein 256740 84592178 An11g00950 Aspergillus niger uncharacterized protein XP_059606307.1 255167 D 5061 CDS An11g00960 4984326 join(256838..256901,256994..257072,257490..257653,257734..257836,258924..259391,259449..260017,260333..260779,260881..260989,261044..261197,261289..261531) VII 1 NT_166526.1 Title: similarity to hypothetical protein encoded by An08g08360 - Aspergillus niger; uncharacterized protein 261531 4984326 An11g00960 Aspergillus niger uncharacterized protein XP_059606308.1 256838 D 5061 CDS An11g00970 4984327 complement(join(262061..262111,262254..264251)) VII 1 NT_166526.1 Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: blastp hits of predicted A. niger protein are likely caused by repetetive sequence motives.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Title: weak similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 9383611; See PMID 9987114; See PMID 11152942; See PMID 8710886; uncharacterized protein 264251 4984327 An11g00970 Aspergillus niger uncharacterized protein XP_001394105.3 262061 R 5061 CDS An11g00980 84592179 join(264291..264299,264386..264511,264767..264826,264915..265037,265136..265387) VII 1 NT_166526.1 Remark: blastp hits are caused by repetetive sequence motives.; hypothetical protein 265387 84592179 An11g00980 Aspergillus niger hypothetical protein XP_059606309.1 264291 D 5061 CDS An11g00990 4984329 join(266290..266415,266488..267219,267284..267754) VII 1 NT_166526.1 Function: in S. cerevisiae Lag1p and Dgt1p redundantely facilitate efficient ER-to-Golgi transport of GPI-anchored proteins.; Remark: deletion of LAG1 increases lifespan by 50% in S. cerevisiae.; Title: strong similarity to ER-to-Golgi transporter Lag1 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 10198056; See PMID 8195187; See PMID 8810036; uncharacterized protein 267754 4984329 An11g00990 Aspergillus niger uncharacterized protein XP_001394107.1 266290 D 5061 CDS An11g01000 4984330 complement(join(269264..269498,269664..271807)) VII 1 NT_166526.1 Function: a two component regulatory system consisting of GacS (sensor kinase) and GacA (transcriptional response regulator) is responsible for regulation of secondary metabolism in P. fluorescens.; Remark: alternative names for P. fluorescens GacS are ApdA and LemA.; Title: similarity to sensor kinase GacS -Pseudomonas fluorescens; plasma membrane; See PMID 10919762; uncharacterized protein 271807 4984330 An11g01000 Aspergillus niger uncharacterized protein XP_003188808.2 269264 R 5061 CDS An11g01010 84592180 272083..272394 VII 1 NT_166526.1 hypothetical protein 272394 84592180 An11g01010 Aspergillus niger hypothetical protein XP_059606310.1 272083 D 5061 CDS An11g01020 84592181 join(272492..272616,272708..272753) VII 1 NT_166526.1 Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 272753 84592181 An11g01020 Aspergillus niger uncharacterized protein XP_059606311.1 272492 D 5061 CDS An11g01040 4984333 join(274745..274800,274872..274992,275015..275149,275233..275298,275616..275804,275872..277199,277255..277469,277525..277794,277851..278050) VII 1 NT_166526.1 Localization: OPT1 of C. albicans is probably located in the plasma membrane.; Similarity: C. albicans OPT1 is not a member of the ABC or PTR membrane transport families.; Title: strong similarity to oligopeptide transporter OPT1 - Candida albicans; See PMID 9043116; uncharacterized protein 278050 4984333 An11g01040 Aspergillus niger uncharacterized protein XP_001394111.3 274745 D 5061 CDS An11g01050 84592182 join(278229..278283,278334..278506) VII 1 NT_166526.1 Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 278506 84592182 An11g01050 Aspergillus niger uncharacterized protein XP_059606312.1 278229 D 5061 CDS An11g01060 4984335 join(278801..280202,280246..281132) VII 1 NT_166526.1 Function: C. lindemuthianum CLTA1 is a regulatory pathogenicity gene involved in the switch between biotrophy and necrotrophy of the infection process.; Similarity: C. lindemuthianum CLTA1 and the predicted A. niger protein contain a Gal4-type fungal zinc cluster (Zn[II](2)Cys(6)) DNA-binding domain.; Title: strong similarity to transcription activator CLTA1 - Colletotrichum lindemuthianum; nucleus; See PMID 11006333; uncharacterized protein 281132 4984335 An11g01060 Aspergillus niger uncharacterized protein XP_059606313.1 278801 D 5061 CDS An11g01070 4984336 join(281328..282677,282811..282909) VII 1 NT_166526.1 Catalytic activity: guanine deaminases catalyse the reaction, guanine + H2O = xanthine + NH3.; Function: human nedasin associates with the MAGUK family protein NE-dlg/SAP102, and interferes with the association between NE-dlg/SAP102 and NMDA receptor 2B in vitro.; Title: strong similarity to guanine deaminase p51-nedasin - Homo sapiens; cytoplasm; See PMID 10542258; uncharacterized protein 282909 4984336 An11g01070 Aspergillus niger uncharacterized protein XP_001394114.3 281328 D 5061 CDS An11g01080 4984337 283210..285327 VII 1 NT_166526.1 Title: strong similarity to hypothetical protein CAF06066.1 - Neurospora crassa; uncharacterized protein 285327 4984337 An11g01080 Aspergillus niger uncharacterized protein XP_001394115.1 283210 D 5061 CDS An11g01090 84592183 complement(join(286491..286820,286894..287007)) VII 1 NT_166526.1 Remark: blastp hits are caused by repetetive sequence motives.; hypothetical protein 287007 84592183 An11g01090 Aspergillus niger hypothetical protein XP_059606314.1 286491 R 5061 CDS An11g01100 4984339 join(<287179..287242,287387..287526,287563..287696,287753..287876,287927..288003,288056..288420,288478..>289120) VII 1 NT_166526.1 Remark: ORF 3'truncated due to end of contig.; Title: strong similarity to high-affinity glucose transporter HGT1 - Kluyveromyces lactis [truncated ORF]; plasma membrane; See PMID 8830679; uncharacterized protein 289120 4984339 An11g01100 Aspergillus niger uncharacterized protein XP_059606315.1 287179 D 5061 CDS An11g01110 4984340 join(290683..290885,290929..291192,291236..291456,291502..291622,291670..292780) VII 1 NT_166526.1 Remark: the predicted intron/exon structure might not be correct (introns missing).; Similarity: the human protein is similar to prokaryotic pepstatin insensitive carboxyl proteases, its deficiency is causing a fatal neurodegenerative disease.; Title: strong similarity to lysosomal pepstatin insensitive protease CLN2 - Homo sapiens; uncharacterized protein 292780 4984340 An11g01110 Aspergillus niger uncharacterized protein XP_001394118.1 290683 D 5061 CDS An11g01120 4984341 complement(join(293269..293308,293395..293444,293535..293597,293704..294045,294101..294229,294280..294474,294525..294617,294669..294753,294804..294817,294879..294966,295021..295067)) VII 1 NT_166526.1 Similarity: shows similarity to several dehydrogenases of different specificities.; Title: strong similarity to NADPH-dependent aldehyde reductase - Sporobolomyces salmonicolor; See PMID 8779568; See PMID 1633196; uncharacterized protein 295067 4984341 An11g01120 Aspergillus niger uncharacterized protein XP_059604246.1 293269 R 5061 CDS An11g01130 84592184 complement(join(295402..295629,295863..295976,296082..296132,296206..296266,296313..296446)) VII 1 NT_166526.1 hypothetical protein 296446 84592184 An11g01130 Aspergillus niger hypothetical protein XP_059604247.1 295402 R 5061 CDS An11g01140 4984343 complement(join(296541..296612,296681..296759,296871..296984,297155..297334,297434..297550,298066..298410,298461..298711)) VII 1 NT_166526.1 Similarity: the ORF encoded protein shows also weak similarity to GTP-binding protein VC0763 from Vibrio cholerae.; Title: weak similarity to hypothetical protein encoded by An16g00260 - Aspergillus niger; uncharacterized protein 298711 4984343 An11g01140 Aspergillus niger uncharacterized protein XP_059604248.1 296541 R 5061 CDS An11g01150 4984344 join(300247..300408,300461..300583,300644..300725,300775..301446,301494..301930) VII 1 NT_166526.1 Function: cytochrome P450s are involved in the oxidative degradation of various compounds.; Similarity: shows similarity to several cytochrome P450 homologs.; Title: similarity to hypothetical cytochrome P450 monooxygenase p450-4 - Gibberella fujikuroi; See PMID 9917370; uncharacterized protein 301930 4984344 An11g01150 Aspergillus niger uncharacterized protein XP_001394122.3 300247 D 5061 CDS An11g01160 84592185 complement(302035..302532) VII 1 NT_166526.1 Function: chitinases catalyze the hydrolysis of the 1,4-beta-linkages of N-acetyl-D-glucosamine polymeres of chitin.; Remark: The deduced protein is much shorter than similar proteins from data banks and shows only similarity to the C-terminal half of chitinases. .; Title: similarity to chitinase Chi1 - Aphanocladium album; See PMID 1735126; uncharacterized protein 302532 84592185 An11g01160 Aspergillus niger uncharacterized protein XP_059604249.1 302035 R 5061 CDS An11g01170 84592186 join(303014..303132,303447..303603,303723..303821) VII 1 NT_166526.1 Title: questionable ORF; uncharacterized protein 303821 84592186 An11g01170 Aspergillus niger uncharacterized protein XP_059604250.1 303014 D 5061 CDS An11g01180 4984347 join(303968..304094,304176..304273,304420..304959,305031..305114) VII 1 NT_166526.1 Title: weak similarity to immunoglobulin kappa light chain - Mus musculus; uncharacterized protein 305114 4984347 An11g01180 Aspergillus niger uncharacterized protein XP_059604251.1 303968 D 5061 CDS An11g01190 4984348 complement(join(305310..306132,306191..306563,306642..306753)) VII 1 NT_166526.1 Title: similarity to protein participating in extracellular/cell surface phenomena Ecm33 - Saccharomyces cerevisiae; See PMID 9335584; See PMID 10734606; uncharacterized protein 306753 4984348 An11g01190 Aspergillus niger uncharacterized protein XP_001394126.1 305310 R 5061 CDS An11g01200 4984349 complement(join(308922..309073,309122..309221,309267..309376,309420..309789,309826..310113,310253..310605,310643..310670)) VII 1 NT_166526.1 Similarity: the ORF also shows strong similarity to the EST an_1007 from Aspergillus niger.; Similarity: the ORF encoded protein shows also weak similarity to the hypothetical protein arcA from Aspergillus nidulans.; Title: similarity to hypothetical protein CAD21260.1 - Neurospora crassa; uncharacterized protein 310670 4984349 An11g01200 Aspergillus niger uncharacterized protein XP_059604252.1 308922 R 5061 CDS An11g01210 84592187 join(310859..311097,311143..311224) VII 1 NT_166526.1 Title: weak similarity to hypothetical protein MTH201 - Methanobacterium thermoautotrophicum; uncharacterized protein 311224 84592187 An11g01210 Aspergillus niger uncharacterized protein XP_059604253.1 310859 D 5061 CDS An11g01220 4984351 complement(join(311369..312234,312290..313028)) VII 1 NT_166526.1 Function: tannase hydrolyzes the ester bonds of tannic acid to produce gallic acid and glucose.; Title: strong similarity to precursor of tannase -Aspergillus oryzae; See PMID 8917102; uncharacterized protein 313028 4984351 An11g01220 Aspergillus niger uncharacterized protein XP_001394129.1 311369 R 5061 CDS An11g01230 84592188 complement(join(313106..313225,313279..313654,313747..313833,313970..314100)) VII 1 NT_166526.1 Title: weak similarity to envelope protein - Spleen focusforming virus; uncharacterized protein 314100 84592188 An11g01230 Aspergillus niger uncharacterized protein XP_059604254.1 313106 R 5061 CDS An11g01240 4984353 complement(join(314583..315389,315457..316196,316305..316462,316568..316622,316803..316887)) VII 1 NT_166526.1 Function: Dfg5p of S. cerevisiae is required for filamentous growth, cell polarity, and cellular elongation.; Title: similarity to filamentous growth protein Dfg5 - Saccharomyces cerevisiae; See PMID 9055077; uncharacterized protein 316887 4984353 An11g01240 Aspergillus niger uncharacterized protein XP_059604255.1 314583 R 5061 CDS An11g01250 84592189 join(317138..317235,317292..317518,317619..317732,318180..319961,319999..320136,320223..320407,320622..320789,320921..321019,321152..321298) VII 1 NT_166526.1 Similarity: shows some similarity to several cyclin-dependent kinases.; Title: weak similarity to cyclin-dependent kinase Cdk8 - Drosophila melanogaster; See PMID 8730095; uncharacterized protein 321298 84592189 An11g01250 Aspergillus niger uncharacterized protein XP_059604256.1 317138 D 5061 CDS An11g01260 4984355 complement(join(321360..321749,321840..322133,322239..322573,322639..322823,322895..322991,323052..323229)) VII 1 NT_166526.1 Similarity: only partial similarity to magnesium/cobalt transport protein sll0671 of Synechocystis, but belongs also to COG0598 and might thus be a metal ion transporter.; Title: weak similarity to hypothetical protein encoded by B1D4.080 - Neurospora crassa; uncharacterized protein 323229 4984355 An11g01260 Aspergillus niger uncharacterized protein XP_001394133.3 321360 R 5061 CDS An11g01270 4984356 join(324759..324793,324839..324866,324914..325152,325206..325492,325571..325628,325681..326236,326285..326373,326429..326642,326697..327020) VII 1 NT_166526.1 Similarity: shows similarity to several putative and known amino-acid transporter proteins.; Title: similarity to amino acid permease Mmp1 -Saccharomyces cerevisiae; plasma membrane; See PMID 10497160; uncharacterized protein 327020 4984356 An11g01270 Aspergillus niger uncharacterized protein XP_059604257.1 324759 D 5061 CDS An11g01280 84592190 complement(join(328129..328293,328396..328468,328565..328640,328739..328922,329083..329157,329262..329342,329419..329433)) VII 1 NT_166526.1 Title: weak similarity to hypothetical protein jhp1206 - Helicobacter pylori; uncharacterized protein 329433 84592190 An11g01280 Aspergillus niger uncharacterized protein XP_059604258.1 328129 R 5061 CDS An11g01290 84592191 join(329634..329649,329711..329848,329895..330017,330088..330199,330281..330494,330620..330878,331397..331648,331776..331883,331969..332054) VII 1 NT_166526.1 hypothetical protein 332054 84592191 An11g01290 Aspergillus niger hypothetical protein XP_059604259.1 329634 D 5061 CDS An11g01300 4984359 complement(join(332441..332465,332535..333798,333892..334090)) VII 1 NT_166526.1 Function: due to SGD RSA2 is involved in ribosome assembly.; Remark: the systematic genename of RSA2 is YMR131c.; Title: strong similarity to protein involved in ribosome assembly Rsa2 - Saccharomyces cerevisiae; uncharacterized protein 334090 4984359 An11g01300 Aspergillus niger uncharacterized protein XP_001394137.1 332441 R 5061 CDS An11g01310 4984360 join(335215..335392,335450..335742,335793..335867,335922..336020) VII 1 NT_166526.1 Similarity: shows strong similarity to several small GTP-binding proteins of the ras superfamily with different specificities.; Title: strong similarity to septum-promoting GTPase spg1p - Schizosaccharomyces pombe; See PMID 9203579; uncharacterized protein 336020 4984360 An11g01310 Aspergillus niger uncharacterized protein XP_001394138.3 335215 D 5061 CDS An11g01320 84592192 join(337190..337498,337806..337862) VII 1 NT_166526.1 hypothetical protein 337862 84592192 An11g01320 Aspergillus niger hypothetical protein XP_059604260.1 337190 D 5061 CDS An11g01330 4984362 join(338797..338862,338932..339094,339157..339290,339427..339508,339580..339683) VII 1 NT_166526.1 Title: similarity to hypothetical protein encoded by SMc00431 - Sinorhizobium meliloti; uncharacterized protein 339683 4984362 An11g01330 Aspergillus niger uncharacterized protein XP_001394140.3 338797 D 5061 CDS An11g01340 4984363 340231..341166 VII 1 NT_166526.1 Function: In Neurospora the expression of a set of unlinked structural genes, which allows utilization of various nitrogen-containing compounds, is controlled by the positive-acting nit-2 gene and the negative-acting nmr gene.; Similarity: The deduced polypeptide is too short (N-term 50 AA; C-term 100 AA) compared to the proteins from data bases.; Title: similarity to nitrogen metabolic regulation protein NMR - Neurospora crassa; See PMID 2146484; uncharacterized protein 341166 4984363 An11g01340 Aspergillus niger uncharacterized protein XP_001394141.3 340231 D 5061 CDS An11g01350 4984364 complement(join(341268..341635,341701..342204,342254..342326,342374..342385)) VII 1 NT_166526.1 Function: the plant protein kinase phosphorylates serine, threonine, and tyrosine.; Remark: the deduced protein is C-terminal approx. 100 AA shorter than the blastp hits.; Similarity: shows also similarity to casein kinase I epsilon CKIe - Xenopus laevis (PUBMED 10517632).; Title: similarity to protein kinase ADK1 -Arabidopsis thaliana; See PMID 7527390; uncharacterized protein 342385 4984364 An11g01350 Aspergillus niger uncharacterized protein XP_059604261.1 341268 R 5061 CDS An11g01360 84592193 join(343095..343488,343626..344944) VII 1 NT_166526.1 Similarity: Similarity to several proteins is based on repetetive sequence.; hypothetical protein 344944 84592193 An11g01360 Aspergillus niger hypothetical protein XP_059604262.1 343095 D 5061 CDS An11g01370 84592194 complement(join(345033..345055,345139..345234,345325..345382,345421..345486)) VII 1 NT_166526.1 Similarity: similarities to several proteins are based on a 'D-rich' region.; hypothetical protein 345486 84592194 An11g01370 Aspergillus niger hypothetical protein XP_059604263.1 345033 R 5061 CDS An11g01380 84592195 join(345599..345861,346140..346194) VII 1 NT_166526.1 hypothetical protein 346194 84592195 An11g01380 Aspergillus niger hypothetical protein XP_059604264.1 345599 D 5061 CDS An11g01390 4984368 346348..347373 VII 1 NT_166526.1 Function: the bacterial enzyme catalyzes the oxidation of D-3-phosphoglycerate to 3-phosphohydroxypyruvate. It is the first committed step in the 'phosphorylated' pathway of serine biosynthesis.; Similarity: shows also similarity to glycerate dehydrogenase hprA - Pseudomonas aeruginosa (EC: 1. 1. 1. 29).; Title: similarity to phosphoglycerate dehydrogenase serA - Bacillus subtilis; See PMID 7934829; uncharacterized protein 347373 4984368 An11g01390 Aspergillus niger uncharacterized protein XP_001394146.1 346348 D 5061 CDS An11g01400 4984369 join(347891..348287,348849..348872,349066..349100) VII 1 NT_166526.1 Title: similarity to hypothetical protein CAB92029.2 - Neurospora crassa; uncharacterized protein 349100 4984369 An11g01400 Aspergillus niger uncharacterized protein XP_001394147.3 347891 D 5061 CDS An11g01410 4984370 join(350115..350385,350436..350567,350617..350919,350964..351745) VII 1 NT_166526.1 Function: members of the ATZ/TRZ family catalyse hydrolytic dechlorination of their substrates.; Remark: The bacterial enzyme catalyzes the dechlorination of atrazine to hydroxyatrazine via a hydrolytic reaction.; Title: similarity to atrazine chlorohydrolase atzA -Pseudomonas sp.; See PMID 8759853; uncharacterized protein 351745 4984370 An11g01410 Aspergillus niger uncharacterized protein XP_001394148.1 350115 D 5061 CDS An11g01420 4984371 352184..353371 VII 1 NT_166526.1 Similarity: N-terminal half shows some similarity to N-terminal half of several yeast transcription factors.; Title: weak similarity to transcription activator Cad1 - Saccharomyces cerevisiae; uncharacterized protein 353371 4984371 An11g01420 Aspergillus niger uncharacterized protein XP_059604265.1 352184 D 5061 CDS An11g01430 4984372 complement(join(353826..354142,354610..354740,354812..354978,355036..355302)) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein CAC18266.1 - Neurospora crassa; uncharacterized protein 355302 4984372 An11g01430 Aspergillus niger uncharacterized protein XP_059604266.1 353826 R 5061 CDS An11g01470 84592196 join(357686..357694,357990..358071,358204..358580) VII 1 NT_166526.1 hypothetical protein 358580 84592196 An11g01470 Aspergillus niger hypothetical protein XP_059604267.1 357686 D 5061 CDS An11g01480 84592197 complement(join(359029..359095,359230..359313,359514..359570,359716..359787,359840..359913)) VII 1 NT_166526.1 Title: weak similarity to hypothetical RNA polymerase - Pelargonium leaf curl virus; uncharacterized protein 359913 84592197 An11g01480 Aspergillus niger uncharacterized protein XP_059604268.1 359029 R 5061 CDS An11g01490 84592198 complement(join(360297..360649,360858..360984)) VII 1 NT_166526.1 Similarity: shows similarity to the C-terminal half of the phage protein.; Title: weak similarity to protein 40A - Phage phi80; uncharacterized protein 360984 84592198 An11g01490 Aspergillus niger uncharacterized protein XP_059604269.1 360297 R 5061 CDS An11g01500 84592199 join(361013..361097,361187..361247,361389..361649,361706..361868,361924..361993,362072..362259,362403..362588,362684..363038,363114..363216,363312..363399,363505..363591) VII 1 NT_166526.1 hypothetical protein 363591 84592199 An11g01500 Aspergillus niger hypothetical protein XP_059604270.1 361013 D 5061 CDS An11g01510 4984380 complement(join(363856..364477,364603..366182)) VII 1 NT_166526.1 Title: weak similarity to the protein involved in sister chromatid segregation Src1 - Saccharomyces cerevisiae; uncharacterized protein 366182 4984380 An11g01510 Aspergillus niger uncharacterized protein XP_001394155.1 363856 R 5061 CDS An11g01520 4984381 complement(join(367183..367476,367538..372793,372931..373524)) VII 1 NT_166526.1 Catalytic activity: adenylate cyclases catalyze the conversion of ATP = 3',5'-Cyclic AMP + Pyrophosphate; Function: adenylate cyclases play essential roles in regulation of cellular metabolism by catalysing the synthesis of a second messenger, cAMP.; Title: strong similarity to adenylate cyclase MAC1 -Magnaporthe grisea; See PMID 9707535; uncharacterized protein 373524 4984381 An11g01520 Aspergillus niger uncharacterized protein XP_001394156.3 367183 R 5061 CDS An11g01530 84592200 join(374125..374166,374400..374433,374518..374564,374654..374738,374821..374874,374941..375100,375635..375824,376118..376354,377321..377400,377475..377564,377650..377704,377787..377868,378359..378528) VII 1 NT_166526.1 Title: questionable ORF; uncharacterized protein 378528 84592200 An11g01530 Aspergillus niger uncharacterized protein XP_059604271.1 374125 D 5061 CDS An11g01540 4984383 join(378916..379012,379066..379620,379693..380090) VII 1 NT_166526.1 Function: members of this family of putative glycosidases (CRH1, CRH2, and CRR1) might exert a common role in cell wall organization at different stages of the yeast life cycle.; Localization: CRH1 of S. cerevisiae is localized at the cell surface, particularly in chitin-rich areas.; Remark: the systematic genename of CRH1 of S. cerevisiae is YGR189C.; Similarity: shows also similarities to several endo-glucanases.; Similarity: strong similarity to allergen rAsp f 9 of Aspergillus fumigatus.; Title: strong similarity to cell wall protein Crh1 -Saccharomyces cerevisiae; cell wall; See PMID 10757808; uncharacterized protein 380090 4984383 An11g01540 Aspergillus niger uncharacterized protein XP_001394158.3 378916 D 5061 CDS An11g01550 4984384 complement(join(380976..381059,381139..381919,381994..382558,382645..382780)) VII 1 NT_166526.1 Function: The C. maltosa enzyme catalyzes the hydroxylation of n-hexadecane and lauric acid.; Function: cytochrome P450s are involved in the oxidative degradation of various compounds.; Title: strong similarity to cytochrome P450 52A4 -Candida maltosa; See PMID 9501474; See PMID 9717384; uncharacterized protein 382780 4984384 An11g01550 Aspergillus niger uncharacterized protein XP_001394159.3 380976 R 5061 CDS An11g01560 84592201 complement(join(382968..383042,383102..383570,383656..383684)) VII 1 NT_166526.1 Similarity: shows minor similarity to central part of probable PPE protein (G70570) of M. tuberculosis.; hypothetical protein 383684 84592201 An11g01560 Aspergillus niger hypothetical protein XP_059604272.1 382968 R 5061 CDS An11g01570 4984386 join(383726..384154,384231..385265) VII 1 NT_166526.1 Function: Nab2p of S. cerevisiae is an essential protein binding to polyadenylated RNA and single-stranded DNA.; Remark: Nab2p of S. cerevisiae is believed to associate directly with nascent RNA polymerase II transcripts and remain associated during subsequent nuclear RNA processing reactions.; Remark: Nab2p of S. cerevisiae may be involved not only in RNA processing but also in transcription regulation.; Similarity: the similarity of this ORF to Nab2p of S. cerevisisae can be discussed, since there are a number of gaps and only few stretches showing significant similarity, thus we do not consider to make a functional prediction on this ORF.; Title: similarity to nuclear polyadenylated RNA-binding protein Nab2 - Saccharomyces cerevisiae; See PMID 8474438; uncharacterized protein 385265 4984386 An11g01570 Aspergillus niger uncharacterized protein XP_059604273.1 383726 D 5061 CDS An11g01580 4984387 join(385735..386058,386139..386819,386909..387676) VII 1 NT_166526.1 Catalytic activity: protoporphyrinogen oxidase catalyzes the conversion of protoporphyrinogen IX + O2 = Protoporphyrin IX + H2O.; Pathway: porphyrin metabolism.; Title: similarity to protoporphyrinogen oxidase PPO - Mus musculus; See PMID 8554330; uncharacterized protein 387676 4984387 An11g01580 Aspergillus niger uncharacterized protein XP_059604274.1 385735 D 5061 CDS An11g01590 84592202 join(387904..388056,388119..388139,388158..388172) VII 1 NT_166526.1 hypothetical protein 388172 84592202 An11g01590 Aspergillus niger hypothetical protein XP_059604275.1 387904 D 5061 CDS An11g01600 4984389 complement(388221..388883) VII 1 NT_166526.1 Title: similarity to polypeptide SEQ ID NO:21825 from patent WO200171042-A2 - Drosophila melanogaster; uncharacterized protein 388883 4984389 An11g01600 Aspergillus niger uncharacterized protein XP_001394164.1 388221 R 5061 CDS An11g01610 4984390 join(390676..396860,396919..397186) VII 1 NT_166526.1 Catalytic activity: ubiquitin-protein ligases catalyze the conversion of ATP + Ubiquitin + Protein lysine = AMP + Pyrophosphate + Protein N-ubiquityllysine.; Remark: in most cases ubiquitinated proteins will be degraded.; Remark: the systematic gene name of UBR1 is YGR184C.; Title: similarity to ubiquitin protein ligase Ubr1 -Saccharomyces cerevisiae; uncharacterized protein 397186 4984390 An11g01610 Aspergillus niger uncharacterized protein XP_001394165.1 390676 D 5061 CDS An11g01620 84592203 join(397874..398039,398209..398295,398369..398406,398606..398626) VII 1 NT_166526.1 hypothetical protein 398626 84592203 An11g01620 Aspergillus niger hypothetical protein XP_059604276.1 397874 D 5061 CDS An11g01630 4984392 join(398633..398969,399034..399692) VII 1 NT_166526.1 Function: nmt2 of S. pombe is involved in the biosynthesis of the thiamine precursor thiazole.; Induction: nmt2 of S. pombe is repressed by thiazole.; Remark: a splice site was detected upstream of the START codon.; Similarity: belongs to the thi4 family.; Similarity: strong similarity to stress-inducible protein sti35 - Fusarium oxysporum; Title: strong similarity to thiazole biosynthesis protein nmt2p - Schizosaccharomyces pombe; See PMID 7992507; See PMID 9606189; uncharacterized protein 399692 4984392 An11g01630 Aspergillus niger uncharacterized protein XP_001394167.1 398633 D 5061 CDS An11g01640 4984393 complement(400138..401571) VII 1 NT_166526.1 Catalytic activity: phospholipase C catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.; EC:3.1.4.11; Function: phospholipase C type enzymes hydrolyze inositolphosphosphingolipids (IPC, MIPC, M(IP)2C) as well as sphingomyelin.; Phenotype: the ISC2 null mutant of S. cerevisisae is viable and contains more inositolphosphosphingolipids.; Remark: the systematic name of ISC2 is YER019w.; Similarity: shows also similarity to probable lipid metabolism protein with similarity to sphingomyelinase family of S. pombe.; Title: similarity to phospholipase C type Isc2 -Saccharomyces cerevisiae; See PMID 11006294; uncharacterized protein 401571 4984393 An11g01640 Aspergillus niger uncharacterized protein XP_059604277.1 400138 R 5061 CDS An11g01650 4984394 join(401959..402607,402685..402848,402914..403834) VII 1 NT_166526.1 Similarity: shows similarity only to the WD-repeat domains of these proteins.; Similarity: shows similarity to several WD-repeat proteins of different organisms.; Title: similarity to beta transducin-like protein het-e1 - Podospora anserina; See PMID 10322433; uncharacterized protein 403834 4984394 An11g01650 Aspergillus niger uncharacterized protein XP_001394169.1 401959 D 5061 CDS An11g01660 4984395 complement(404993..405844) VII 1 NT_166526.1 Title: similarity to hypothetical protein B24P11.210 - Neurospora crassa; uncharacterized protein 405844 4984395 An11g01660 Aspergillus niger uncharacterized protein XP_001394170.1 404993 R 5061 CDS An11g01670 84592204 join(405996..406119,406189..406389,406465..406540,406632..406733,406930..407200,407339..407449) VII 1 NT_166526.1 Title: weak similarity to brain development related protein LjOtxA - Lampetra japonica; uncharacterized protein 407449 84592204 An11g01670 Aspergillus niger uncharacterized protein XP_059604278.1 405996 D 5061 CDS An11g01680 84592205 complement(join(408111..408200,408276..408434,408506..408569,408676..408724,409015..409047,409209..409293)) VII 1 NT_166526.1 hypothetical protein 409293 84592205 An11g01680 Aspergillus niger hypothetical protein XP_059604279.1 408111 R 5061 CDS An11g01690 4984398 join(411066..411074,411160..411171,411255..411398,411515..411538) VII 1 NT_166526.1 Remark: belongs to the S30E family of ribosomal proteins.; Remark: there are two genes for S30 in S. cerevisiae (RPS30B;YOR182c and RPS30A;YLR287c-a).; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S30 - Saccharomyces cerevisiae; cytoplasm; 40S ribosomal protein eS30 411538 4984398 An11g01690 Aspergillus niger 40S ribosomal protein eS30 XP_001394173.1 411066 D 5061 CDS An11g01700 4984399 complement(join(412298..413930,414030..414085)) VII 1 NT_166526.1 Function: RTG2 of S. cerevisiae is a pivotal gene in controlling interorganelle communication between mitochondria, peroxisomes, and the nucleus in the context of retrograde regulation.; Function: RTG2 of S. cerevisiae is required, in particular, for the retrograde expression of the peroxisomal isoform of citrate synthase, cit2.; Function: the expression of some nuclear genes is sensitive to the functional state of mitochondria, a process termed retrograde regulation.; Phenotype: S. cerevisiae cells bearing a RTG2 null mutation are viable and respiratory competent; however,they are auxotrophic for glutamic or aspartic acid and cannot use acetate as a sole carbon source, suggesting that both the tricarboxylic acid and glyoxylate cycles are compromised.; Similarity: RTG2 of S. cerevisiae contains an N-terminal ATP binding domain similar to that found in hsp70 homologues, and shares some sequence similarity with phosphatases.; Title: strong similarity to regulator protein Rtg2 -Saccharomyces cerevisiae; cytoplasm; See PMID 7629125; See PMID 8422683; See PMID 10848632; uncharacterized protein 414085 4984399 An11g01700 Aspergillus niger uncharacterized protein XP_001394174.1 412298 R 5061 CDS An11g01710 84592206 complement(join(414756..414872,414943..415487,415530..415641)) VII 1 NT_166526.1 Title: weak similarity to ATP:scyllo-inosamine phosphatransferase stsE - Streptomyces griseus; See PMID 9238101; uncharacterized protein 415641 84592206 An11g01710 Aspergillus niger uncharacterized protein XP_059604280.1 414756 R 5061 CDS An11g01720 4984401 complement(join(415920..416239,416292..416619,416675..417146,417203..417367,417424..417457,417583..417811)) VII 1 NT_166526.1 Function: TNA1 of S. cerevisiae is necessary for nicotinic acid import into the cell.; Remark: TNA1 of S. cerevisiae is also called YGR260w.; Similarity: TNA1 of S. cerevisiae is a members of the yeast Dal5p (allantoate/ureidosuccinate permease) subfamily of the major facilitator family of tranmembrane transporters.; Similarity: the Dal family proteins are weakly similar to bacterial (hypothetical) permeases for tartrate (ttuB), 4-hydroxyphenylacetate (hpaX), phtalate (Pht1),suggesting that proteins of the Dal family correspond to permeases for carboxylic acids.; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563; uncharacterized protein 417811 4984401 An11g01720 Aspergillus niger uncharacterized protein XP_001394176.1 415920 R 5061 CDS An11g01730 84592207 complement(join(418394..418497,418585..418785,418871..418904)) VII 1 NT_166526.1 hypothetical protein 418904 84592207 An11g01730 Aspergillus niger hypothetical protein XP_059604281.1 418394 R 5061 CDS An11g01740 4984403 join(418969..419004,419087..419350,419418..421196) VII 1 NT_166526.1 Similarity: the similarity to SPBP23A10. 05 of S. pombe is limited to the N-terminus of the predicted ORF.; Title: similarity to hypothetical coiled-coil protein SPBP23A10.05 - Schizosaccharomyces pombe; uncharacterized protein 421196 4984403 An11g01740 Aspergillus niger uncharacterized protein XP_001394178.1 418969 D 5061 CDS An11g01750 4984404 join(422061..422759,422967..423106,423459..423963,424022..425113) VII 1 NT_166526.1 Similarity: stretches of repetitive elements at the N- and C-termini show weak similarity with the circumsporozoite protein of Plasmodium vivax.; Similarity: the similarity with YGR086c of S. cerevisiae is strong in the central part of the molecule.; Title: similarity to hypothetical protein YGR086c -Saccharomyces cerevisiae; uncharacterized protein 425113 4984404 An11g01750 Aspergillus niger uncharacterized protein XP_059604282.1 422061 D 5061 CDS An11g01760 4984405 join(425280..425657,425809..425916,425971..426178,426306..426415,426476..426811) VII 1 NT_166526.1 Catalytic activity: PRE2 has a chymotrypsin-like proteolytic activity.; Complex: the 20 S proteasome is a cylindrical particle with two outer rings each made of 7 different alpha-type subunits and two inner rings made of 7 different beta-type subunits. S. cerevisiae Pre2p is the beta 5 subunit.; Complex: the 20S proteasome from the yeast S. cerevisiae is composed by 28 protein subunits, and constitutes the proteolytic core of the larger 26S proteasome complex.; Function: the 26 S proteasome is the central protease involved in ubiquitin-mediated protein degradation and fulfills vital regulatory functions in eukaryotes.; Localization: proteasomes are mainly localised in the in the nuclear envelope-ER network.; Remark: PRE2 of S. cerevisiae is also called DOA3,PRG1,or SRR2.; Remark: PRE2 of S. cerevisiae is synthesized as precursor and is processed in a manner apparently identical to that of related mammalian proteasome subunits implicated in antigen presentation.; Similarity: PRE2 of S. cerevisiae is a beta-type member of the proteasomal gene family.; Similarity: part of the predicted ORF is identical to A. niger EST EMBLEST Acc. BE758781; gaps in the BLASTP alignments were not corrected by gene modeling due to the experimentally derived mRNA evidence.; Similarity: the PRE2 protein of S. cerevisiae shows striking homology to the human Ring10 protein, which is encoded in the major histocompatibility complex class II region and have sequence homology to proteasome-encoding genes.; Title: strong similarity to proteasome 20S subunit Pre2 - Saccharomyces cerevisiae; See PMID 7781614; See PMID 8383129; See PMID 9087403; See PMID 9312134; uncharacterized protein 426811 4984405 An11g01760 Aspergillus niger uncharacterized protein XP_059604283.1 425280 D 5061 CDS An11g01770 4984406 complement(join(427250..427457,427527..428019,428076..430515,430593..431093)) VII 1 NT_166526.1 Catalytic activity: n nucleoside triphosphate = n pyrophosphate + RNA(n).; Complex: RNA polymerase I consists of 14 different subunits; this subunit is the second largest component of RNA polymerase I.; Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; RNA polymerase I is essentially used to transcribe ribosomal DNA units.; Phenotype: N. crassa strain un-18, producing a temperature-sensitive mutant of the RNA polymerase I 135K subunit, shows alterations of the period of the circadian conidiation rhythm.; Similarity: belongs to the RNA polymerase beta chain family.; Similarity: very strong similarity to RNA polymerase I subunit of different species.; Title: strong similarity to 135 kD subunit of DNA-directed RNA polymerase I - Neurospora crassa; nucleus; See PMID 9749669; See PMID 1990281; uncharacterized protein 431093 4984406 An11g01770 Aspergillus niger uncharacterized protein XP_059604284.1 427250 R 5061 CDS An11g01780 84592208 complement(join(431825..431913,432012..432112,432197..432303,432396..432401)) VII 1 NT_166526.1 hypothetical protein 432401 84592208 An11g01780 Aspergillus niger hypothetical protein XP_059604285.1 431825 R 5061 CDS An11g01790 4984408 join(432680..432729,432854..432926,433002..433021,433092..433154,433220..433291,433356..433629) VII 1 NT_166526.1 Function: ADP-ribosylation factors (ARF) are 20 Kd GTP-binding proteins involved in protein trafficking, which may modulate vesicle budding and uncoating within the Golgi apparatus.; Function: ARF1 of T. gondii can augment release of constitutively secreted vesicles at the target membrane.; Function: ARFs also act as allosteric activators of cholera toxin ADP-ribosyltransferase activity.; Golgi; Localization: ARF1 of T. gondii is located in the Golgi/TGN.; Similarity: the protein shows strong similarity to many ADP-ribosylation factor-like proteins of different plant and animal species.; Title: strong similarity to ADP ribosylation factor 1 ARF1 - Toxoplasma gondii; See PMID 11208125; See PMID 11210540; See PMID 11278405; uncharacterized protein 433629 4984408 An11g01790 Aspergillus niger uncharacterized protein XP_001394183.1 432680 D 5061 CDS An11g01800 84592209 complement(join(436017..436085,436624..436704,436746..436842,436866..436951)) VII 1 NT_166526.1 Title: questionable ORF; uncharacterized protein 436951 84592209 An11g01800 Aspergillus niger uncharacterized protein XP_059604286.1 436017 R 5061 CDS An11g01810 4984410 join(437025..437053,437178..437291,437357..437672) VII 1 NT_166526.1 Similarity: due to the polyglutamine and polyproline stretches, the protein shows weak similarities with polyglutamine-containing proteins (like huntingtin), or polyprolin-containing proteins (like extensins).; Title: weak similarity to hypothetical membrane protein YBR005w - Saccharomyces cerevisiae; uncharacterized protein 437672 4984410 An11g01810 Aspergillus niger uncharacterized protein XP_001394185.1 437025 D 5061 CDS An11g01820 84592210 join(438227..438363,438527..438819,438946..439274) VII 1 NT_166526.1 hypothetical protein 439274 84592210 An11g01820 Aspergillus niger hypothetical protein XP_059604287.1 438227 D 5061 CDS An11g01830 4984412 join(439765..439883,439946..441089) VII 1 NT_166526.1 Similarity: the protein shows similarity to extensins of several species due to the high proline content.; Title: similarity to hypothetical fibroin-3 related protein B14D6.620 - Neurospora crassa; uncharacterized protein 441089 4984412 An11g01830 Aspergillus niger uncharacterized protein XP_001394187.1 439765 D 5061 CDS An11g01840 4984413 complement(join(441757..442851,442932..443442,443494..443507)) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein SPAC1F3.09 - Schizosaccharomyces pombe; uncharacterized protein 443507 4984413 An11g01840 Aspergillus niger uncharacterized protein XP_059604288.1 441757 R 5061 CDS An11g01850 4984414 join(444005..445443,445509..>451837) VII 1 NT_166526.1 Remark: a putative sequencing error results in an frameshift.; Similarity: the protein shows strong similarity to the DRIM protein of Homo sapiens, a gene with unknown function, which is downregulated in tumor metastasis.; Title: strong similarity to hypothetical protein SPBC56F2.04 - Schizosaccharomyces pombe [putative frameshift]; putative frameshift; See PMID 9673349; uncharacterized protein 451837 4984414 An11g01850 Aspergillus niger uncharacterized protein XP_059604289.1 444005 D 5061 CDS An11g01860 4984415 complement(452137..452712) VII 1 NT_166526.1 Remark: SPAC24H6. 02c in S. pombe is contiguous to the cullin 3 homolog on chromosome 1.; Title: strong similarity to hypothetical protein SPAC24H6.02c - Schizosaccharomyces pombe; uncharacterized protein 452712 4984415 An11g01860 Aspergillus niger uncharacterized protein XP_001394190.1 452137 R 5061 CDS An11g01870 4984416 join(453141..453182,453310..453696,453763..455636,455693..455864) VII 1 NT_166526.1 Function: Cul3 of M. musculus and H. sapiens is important for the ubiquitination and degradation of free cyclin E (i. e. not bound to Cdk2).; Function: cyclin E controls the G1/S phase transition.; Localization: Cul3 of M. musculus and H. sapiens is located both in the nucleus and in the Golgi apparatus; the Golgi localization suggests that Cul3 might have additional substrates.; Phenotype: homozygous deletion of the Cul3 gene in mouse causes an embryonic lethal phenotype due to abnormal regulation of S phase in extraembrioniyc ectodermal and trophoblastic cells.; Similarity: Cul3 belongs to the cullin family of E3 ubiquitin-protein ligases; it was demonstrated that it exherts very similar functions in man and mouse; Title: strong similarity to cullin 3 Cul3 - Mus musculus; nucleus; See PMID 10500095; uncharacterized protein 455864 4984416 An11g01870 Aspergillus niger uncharacterized protein XP_001394191.1 453141 D 5061 CDS An11g01880 4984417 complement(join(456362..456982,457075..457398)) VII 1 NT_166526.1 Title: similarity to hypothetical protein YDR489w -Saccharomyces cerevisiae; uncharacterized protein 457398 4984417 An11g01880 Aspergillus niger uncharacterized protein XP_001394192.3 456362 R 5061 CDS An11g01890 4984418 complement(join(458360..459488,459554..459778,459836..459898,459980..460233)) VII 1 NT_166526.1 Catalytic activity: protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.; Function: dephosphorylates O-phosphotyrosine groups in phosphoproteins.; Function: nimT of A. nidulans is required for mitosis.; Function: nimT of A. nidulans is required for tyrosine dephosphorylation of p34cdc2 and has a strong homology to cdc25-type proteins.; Title: strong similarity to tyrosine phosphatase nimT - Aspergillus nidulans; See PMID 1534750; See PMID 6352675; uncharacterized protein 460233 4984418 An11g01890 Aspergillus niger uncharacterized protein XP_059604290.1 458360 R 5061 CDS An11g01900 84592211 complement(join(462586..462726,462799..462822,462900..463130,463217..463267,463304..463312)) VII 1 NT_166526.1 hypothetical protein 463312 84592211 An11g01900 Aspergillus niger hypothetical protein XP_059604291.1 462586 R 5061 CDS An11g01910 84592212 complement(join(464110..464220,464422..464552,464615..464722,464811..465222)) VII 1 NT_166526.1 Remark: partial similarities to different database entries.; hypothetical protein 465222 84592212 An11g01910 Aspergillus niger hypothetical protein XP_059604292.1 464110 R 5061 CDS An11g01920 84592213 join(466117..466329,466619..466693,466819..466949,467053..467127,467171..467250,467343..467452) VII 1 NT_166526.1 hypothetical protein 467452 84592213 An11g01920 Aspergillus niger hypothetical protein XP_059604293.1 466117 D 5061 CDS An11g01930 84592214 complement(469010..470938) VII 1 NT_166526.1 Function: ankyrins attach integral membrane proteins to cytoskeletal elements.; Localization: ank1 of H. sapiens binds to the erythrocyte membrane protein band 4. 2, to Na-K ATPase, to the lymphocyte membrane protein gp85, and to skeletal proteins fodrin, tubulin, vimentin and desmin.; Remark: several splice forms of the human ank1 are known.; Similarity: similarity is restricted to the N-terminal part of ank1.; Title: similarity to ankyrin ANK1 - Homo sapiens; cytoskeleton; See PMID 11018513; uncharacterized protein 470938 84592214 An11g01930 Aspergillus niger uncharacterized protein XP_059604294.1 469010 R 5061 CDS An11g01940 4984423 join(472159..472459,472539..472858) VII 1 NT_166526.1 Remark: protein shows partial similarities to different protein kinase motifs.; Title: weak similarity to hypothetical protein encoded by An01g12000 - Aspergillus niger; uncharacterized protein 472858 4984423 An11g01940 Aspergillus niger uncharacterized protein XP_059604295.1 472159 D 5061 CDS An11g01950 4984424 join(473750..474121,474185..474773,474824..475629,475678..475980,476032..476916) VII 1 NT_166526.1 Title: strong similarity to DNA polymerase V Pol5 -Saccharomyces cerevisiae; nucleus; See PMID 7667891; See PMID 8953036; uncharacterized protein 476916 4984424 An11g01950 Aspergillus niger uncharacterized protein XP_001394199.1 473750 D 5061 CDS An11g01960 4984425 complement(join(477078..477334,477359..>478112)) VII 1 NT_166526.1 Catalytic activity: transulphurylation reaction.; Function: hxB of A. nidulans is necessary for the post-translational activation of purine hydroxylases (molybdenum-containing enzymes of the hydroxylase class) by attaching a terminal sulfur atom to the molybdenum cofactor.; Function: the molybdopterin cofactor is required for the activity of a variety of oxidoreductases.; Remark: truncated ORF due to the contig end.; Title: similarity to transsulphurylation protein hxB - Aspergillus nidulans [truncated ORF]; See PMID 10096075; See PMID 11029694; uncharacterized protein 478112 4984425 An11g01960 Aspergillus niger uncharacterized protein XP_059604296.1 477078 R 5061 CDS An11g01970 4984426 complement(join(478496..479206,479263..479373)) VII 1 NT_166526.1 Function: PGPI of P. furiosus releases an N-terminal pyroglutamyl group from a polypeptide, provided the next residue is not proline.; Remark: PGPI is inhibited by thiol-blocking reagents.; Similarity: PGPI belongs to peptidase family C15.; Title: similarity to pyroglutamyl-peptidase I PGPI -Pyrococcus furiosus; See PMID 10552639; See PMID 9920379; uncharacterized protein 479373 4984426 An11g01970 Aspergillus niger uncharacterized protein XP_001394201.1 478496 R 5061 CDS An11g01980 4984427 join(480374..480526,480580..480852,480903..481019,481096..481180,481233..481301,481352..481957,482025..482455) VII 1 NT_166526.1 Function: this P450 of G. fujikuroi is, together with three similar P450 monooxygenases, a putative geranylgeranyl diphosphate synthase, and a copalyl diphosphate synthase, involved in gibberellin biosynthesis.; Title: strong similarity to cytochrome P450 monooxygenase P450II - Gibberella fujikuroi; See PMID 10531641; See PMID 9917370; uncharacterized protein 482455 4984427 An11g01980 Aspergillus niger uncharacterized protein XP_059601529.1 480374 D 5061 CDS An11g01990 4984428 487585..489582 VII 1 NT_166526.1 Remark: blast hits based on repetitive sequence.; hypothetical protein 489582 4984428 An11g01990 Aspergillus niger hypothetical protein XP_001394203.1 487585 D 5061 CDS An11g02000 4984429 complement(join(491509..493721,493797..494244,494352..495341)) VII 1 NT_166526.1 Function: sldA of E. nidulans plays a role in mitosis.; Remark: mutations in sldA and sldB of E. nidulans confer hypersensitivity to the microtubule-destabilizing drug benomyl.; Remark: mutations in sldA and sldB show a strong synthetic lethal interaction with a mutation in the mitotic kinesin bimC.; Title: strong similarity to spindle assembly checkpoint protein sldA - Aspergillus nidulans; See PMID 9584089; uncharacterized protein 495341 4984429 An11g02000 Aspergillus niger uncharacterized protein XP_001394204.1 491509 R 5061 CDS An11g02010 4984430 join(496442..496671,496730..496903,496934..497840) VII 1 NT_166526.1 Catalytic activity: endonucleolytic cleavage near apurinic or apyrimidinic sites to products with 5'-phosphate.; Cofactor: contains 3. 3 zinc atoms and no significant manganese.; Function: apn1 of S. cerevisiae accounts for > 97% of both apurinic/apyrimidinic (ap) endonuclease and DNA 3'-repair diesterase activities.; Remark: based on sequence similarity to apn1 of S. cerevisiae an additional intron might be present around AA position 290 (length approx. 30 AA).; Similarity: belongs to ap endonucleases family 2.; Title: strong similarity to apurinic endonuclease Apn1 - Saccharomyces cerevisiae; nucleus; See PMID 1693433; uncharacterized protein 497840 4984430 An11g02010 Aspergillus niger uncharacterized protein XP_059601530.1 496442 D 5061 CDS An11g02020 4984431 complement(join(498330..499703,499765..500013)) VII 1 NT_166526.1 Function: GPT of Z. mays mediates a 1:1 exchange of glucose 6-phosphate mainly with inorganic phosphate and triose phosphates.; Remark: GPT was isolated from plastids of Z. mays,its expression is mainly restricted to heterotrophic tissues.; Similarity: closest manual homologue (BLASTP): PIR:T01210 glucose-6-phosphate/phosphate-translocator precursor - Zea mays.; Title: similarity to glucose-6-phosphate/phosphate-translocator GPT - Zea mays [putative sequencing error]; putative sequencing error; See PMID 9477574; uncharacterized protein 500013 4984431 An11g02020 Aspergillus niger uncharacterized protein XP_001394206.3 498330 R 5061 CDS An11g02030 4984432 complement(join(506239..506273,506348..506399,506450..506936,507082..507125)) VII 1 NT_166526.1 Title: similarity to hypothetical protein T23E23.20 - Arabidopsis thaliana; uncharacterized protein 507125 4984432 An11g02030 Aspergillus niger uncharacterized protein XP_001394207.3 506239 R 5061 CDS An11g02040 4984433 complement(join(508165..508605,508667..509095,509159..509610,509673..509860,510218..510234)) VII 1 NT_166526.1 Catalytic activity: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.; Title: strong similarity to phosphogluconate dehydrogenase Gnd1 - Saccharomyces cerevisiae; See PMID 1328471; uncharacterized protein 510234 4984433 An11g02040 Aspergillus niger uncharacterized protein XP_059601531.1 508165 R 5061 CDS An11g02050 4984434 512588..513286 VII 1 NT_166526.1 Function: RBD (RNA binding) proteins can enhance hybridization of complementary RNAs and may thus mediate the interaction of sense and antisense RNA.; Remark: DdRBP1 is present in equal amounts throughout the developmental cycle of D. discoideum while differential accumulation is observed in nuclei during early and late development.; Remark: a splice site was detected upstream of the START codon.; Similarity: belongs the the RNP-CS family.; Title: similarity to ssRNA-binding protein DdRBP1 -Dictyostelium discoideum; See PMID 9426195; uncharacterized protein 513286 4984434 An11g02050 Aspergillus niger uncharacterized protein XP_001394209.3 512588 D 5061 CDS An11g02060 84592215 complement(join(513433..513498,513585..513825,514073..514188,514364..514498)) VII 1 NT_166526.1 Remark: protein contains a possible DNA helicase subunit motif.; Title: similarity to hypothetical protein encoded by An12g03730 - Aspergillus niger; uncharacterized protein 514498 84592215 An11g02060 Aspergillus niger uncharacterized protein XP_059601532.1 513433 R 5061 CDS An11g02070 4984436 complement(517068..517481) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein encoded by An01g14430 - Aspergillus niger; uncharacterized protein 517481 4984436 An11g02070 Aspergillus niger uncharacterized protein XP_001394211.1 517068 R 5061 CDS An11g02090 4984438 join(518939..519154,519206..519304,519354..519421,519476..520253) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein CAD70545.1 - Neurospora crassa; uncharacterized protein 520253 4984438 An11g02090 Aspergillus niger uncharacterized protein XP_059601533.1 518939 D 5061 CDS An11g02100 4984439 complement(join(521611..521697,521755..522911,522968..523309,523371..523494)) VII 1 NT_166526.1 Complex: F26G of C. speciosus is a heterodimer of a 54kDa (CSF26G1) chain and 58kDa chain.; Function: F26G of C. speciosus catalyses the removal of C-26-bound glucose moiety of furostanol glycosides.; Remark: F26G of C. speciosus is strongly inhibited by diosgenin.; Similarity: F26G of C. speciosus belongs to the superfamily of Agrobacterium beta-glucosidases.; Similarity: similarity to many beta-Glucosidases which hydrolyse the terminal, non-reducing beta-D-glucose residue and release beta-D-glucose.; Title: strong similarity to furostanol glycoside 26-O-beta-glucosidase CSF26G1 - Costus speciosus; See PMID 8549824; See PMID 8766714; uncharacterized protein 523494 4984439 An11g02100 Aspergillus niger uncharacterized protein XP_001394213.1 521611 R 5061 CDS An11g02110 4984440 join(524845..526436,526498..526620,526670..526768,526821..526945,527002..527049,527099..527768,527823..527900,527951..528512,528563..528814,528868..529157,529215..529642,529701..529777,529843..529974) VII 1 NT_166526.1 Function: SNQ2 of S. cerevisiae confers hyper-resistance to the mutagens 4-nitroquinoline-n-oxide (4-nqo) and triaziquone, as well as to the chemicals sulphomethuron phenanthroline when present in multiple copies.; Function: SNQ2 of S. cerevisiae exhibits nucleoside triphosphatase activity.; Function: SNQ2 of S. cerevisiae is an atp-dependent permease.; Localization: integral membrane protein.; Similarity: belongs to the ATP-binding transport protein family (ABC transporters).; Title: strong similarity to multidrug ATP binding cassette transporter Snq2 - Saccharomyces cerevisiae; plasma membrane; See PMID 8437567; See PMID 7629127; uncharacterized protein 529974 4984440 An11g02110 Aspergillus niger uncharacterized protein XP_059601534.1 524845 D 5061 CDS An11g02120 4984441 complement(join(530536..531736,531832..532421)) VII 1 NT_166526.1 Similarity: other similarities are based on repetitive sequences.; Title: strong similarity to hypothetical protein CAD79691.1 - Neurospora crassa; uncharacterized protein 532421 4984441 An11g02120 Aspergillus niger uncharacterized protein XP_001394215.1 530536 R 5061 CDS An11g02140 4984443 complement(join(534671..534712,534820..534974,535066..535264,535339..535407)) VII 1 NT_166526.1 Function: TIM17 of S. cerevisiae is a 16. 5 kda inner membrane protein required for import of mitochondrial precursor proteins.; Remark: SMS1 = MIM17 = TIM17.; Remark: deletion of TIM17 in S. cerevisiae is lethal.; Title: strong similarity to mitochondrial inner membrane protein involved in protein import Tim17 -Saccharomyces cerevisiae; inner membrane; See PMID 8050569; See PMID 7919535; uncharacterized protein 535407 4984443 An11g02140 Aspergillus niger uncharacterized protein XP_001394216.1 534671 R 5061 CDS An11g02150 4984444 complement(join(536020..536765,536838..537739,537789..538335,538392..538611)) VII 1 NT_166526.1 Function: ARO9 (first step of tryptophan,phenylalanine, and tyrosine catabolism) and YDR380w (named ARO10) have similar patterns of transcriptional regulation and are both under the positive control of Aro80p.; Remark: ARO80 is synonymous to YDR421w.; Similarity: ARO80 of S. cerevisiae belongs to the Zn2Cys6 transcription factor family.; Title: strong similarity to transcription factor Aro80 - Saccharomyces cerevisiae; See PMID 10207060; uncharacterized protein 538611 4984444 An11g02150 Aspergillus niger uncharacterized protein XP_059601535.1 536020 R 5061 CDS An11g02160 4984445 539777..540463 VII 1 NT_166526.1 Catalytic activity: 4-Maleylacetoacetate = 4-Fumarylacetoacetate.; EC:5.2.1.2.; Function: maiA of A. nidulans is part of the phenylalanine catabolic pathway.; Similarity: maiA shows strong amino acid sequence similarity to glutathione S-transferases.; Title: strong similarity to maleylacetoacetate isomerase maiA - Aspergillus nidulans; See PMID 9417084; uncharacterized protein 540463 4984445 An11g02160 Aspergillus niger uncharacterized protein XP_001394218.1 539777 D 5061 CDS An11g02170 4984446 complement(540825..542120) VII 1 NT_166526.1 Catalytic activity: 4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate.; Function: use of phenylalanine and phenylacetate as a carbon source.; Induction: by phenylacetate (PhOAc), 2OH-PhOAc,3OH-PhOAc, 4OH-PhOAc, phenylalanine, and tyrosine.; Induction: not induced by acetate or glutamate.; Pathway: last step in the metabolism of tyrosine.; Remark: disruption of the fah gene results in phenylalanine toxicity, secretion of succinylacetone and the absence of growth. This is analogous to the genetic disease, type I hereditary tyrosinaemia (ht1) in humans.; Repression: expression is partially repressed by glucose.; Title: strong similarity to fumarylacetoacetate hydrolase fahA - Aspergillus nidulans; See PMID 7568087; uncharacterized protein 542120 4984446 An11g02170 Aspergillus niger uncharacterized protein XP_001394219.3 540825 R 5061 CDS An11g02180 4984447 join(542622..542689,542760..543269,543325..543975,544026..544173) VII 1 NT_166526.1 Catalytic activity: 3,4-dihydroxyphenylacetate + O(2) = 2-hydroxy-5-carboxymethylmuconate semialdehyde.; Function: HmgA of A. niger catalyzes an essential step in phenylalanine catabolism.; Remark: cofactor is iron.; Title: strong similarity to 3,4-dihydroxyphenylacetate 2,3-dioxygenase hmgA - Aspergillus nidulans; See PMID 7673153; uncharacterized protein 544173 4984447 An11g02180 Aspergillus niger uncharacterized protein XP_001394220.1 542622 D 5061 CDS An11g02190 4984448 complement(544395..545186) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein CAD70480.1 - Neurospora crassa; uncharacterized protein 545186 4984448 An11g02190 Aspergillus niger uncharacterized protein XP_001394221.1 544395 R 5061 CDS An11g02200 4984449 join(545902..546560,546614..546673,546731..547088,547153..547287) VII 1 NT_166526.1 Catalytic activity: 4-hydroxyphenylpyruvate + O(2) = homogentisate + CO(2).; Pathway: participates in the catabolism of tyrosine.; Remark: tcrP of C. immitis is capable of eliciting a proliferative response in a T-cell line that is developed to respond to the soluble conidial wall fractions.; Similarity: belongs to the 4HPPD family.; Title: strong similarity to 4-hydroxyphenylpyruvate dioxygenase tcrP - Coccidioides immitis; See PMID 7642122; uncharacterized protein 547287 4984449 An11g02200 Aspergillus niger uncharacterized protein XP_001394222.1 545902 D 5061 CDS An11g02220 4984451 complement(join(548288..548352,548408..548544,548597..548734,548787..548875,548927..548983,549109..549244,549280..549367,549420..550845)) VII 1 NT_166526.1 Remark: similarity to SPBC18H10. 09 of S. pombe is based on C-terminus of protein.; Title: similarity to hypothetical protein SPBC18H10.09 - Schizosaccharomyces pombe; uncharacterized protein 550845 4984451 An11g02220 Aspergillus niger uncharacterized protein XP_059601536.1 548288 R 5061 CDS An11g02230 4984452 join(551650..551844,551902..553245) VII 1 NT_166526.1 Function: CYP51 of P. italicum catalyses C14-demethylation of lanosterol which is critical for ergosterol biosynthesis.; Function: CYP51 of P. italicum transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.; Pathway: ergosterol biosynthesis.; Remark: CYP51 of P. italicum is inhibited by fungicides.; Remark: mutations in CYP51 or overexpression of CYP51 confers fungicide resistance.; Similarity: CYP51 of P. italicum belongs to the superfamily of human cytochrome P450 CYP51.; Title: strong similarity to lanosterol 14 alpha-demethylase (P450(14DM)) CYP51 - Penicillium italicum; See PMID 8628233; See PMID 9717384; See PMID 10885830; uncharacterized protein 553245 4984452 An11g02230 Aspergillus niger uncharacterized protein XP_001394224.1 551650 D 5061 CDS An11g02240 84592216 join(554993..555058,555164..555188,555295..555521,555581..555943) VII 1 NT_166526.1 hypothetical protein 555943 84592216 An11g02240 Aspergillus niger hypothetical protein XP_059601537.1 554993 D 5061 CDS An11g02250 84592217 complement(join(556501..556685,556835..556910,557042..557149,557219..557246,557335..557358,557473..557587,557768..557918)) VII 1 NT_166526.1 hypothetical protein 557918 84592217 An11g02250 Aspergillus niger hypothetical protein XP_059601538.1 556501 R 5061 CDS An11g02260 84592218 join(559755..559831,560015..560155,560505..560650,560954..561063,561159..561317) VII 1 NT_166526.1 hypothetical protein 561317 84592218 An11g02260 Aspergillus niger hypothetical protein XP_059601539.1 559755 D 5061 CDS An11g02270 4984456 complement(join(563769..565426,565496..565595)) VII 1 NT_166526.1 Similarity: the similarity involves only the N-terminal 15% of the total protein length.; Title: strong similarity to hypothetical protein EAA65021.1 - Aspergillus nidulans; uncharacterized protein 565595 4984456 An11g02270 Aspergillus niger uncharacterized protein XP_001394228.1 563769 R 5061 CDS An11g02280 84592219 join(565871..566006,566122..566196,566274..566297,566394..566458,566703..566861) VII 1 NT_166526.1 hypothetical protein 566861 84592219 An11g02280 Aspergillus niger hypothetical protein XP_059601540.1 565871 D 5061 CDS An11g02290 84592220 complement(join(567422..567492,567688..567746,567869..567956,568041..568146,568230..568289)) VII 1 NT_166526.1 hypothetical protein 568289 84592220 An11g02290 Aspergillus niger hypothetical protein XP_059601541.1 567422 R 5061 CDS An11g02300 84592221 join(568973..569105,569474..569548,569655..569851,569938..570120) VII 1 NT_166526.1 hypothetical protein 570120 84592221 An11g02300 Aspergillus niger hypothetical protein XP_059601542.1 568973 D 5061 CDS An11g02310 84592222 complement(join(570297..570510,570602..570633,570719..570763,570965..571081,571414..571584,571634..571755,572117..572204)) VII 1 NT_166526.1 hypothetical protein 572204 84592222 An11g02310 Aspergillus niger hypothetical protein XP_059601543.1 570297 R 5061 CDS An11g02330 84592223 complement(join(574358..574547,574712..574929)) VII 1 NT_166526.1 hypothetical protein 574929 84592223 An11g02330 Aspergillus niger hypothetical protein XP_059601544.1 574358 R 5061 CDS An11g02340 84592224 join(575487..575615,575692..575694) VII 1 NT_166526.1 Title: questionable ORF; uncharacterized protein 575694 84592224 An11g02340 Aspergillus niger uncharacterized protein XP_059601545.1 575487 D 5061 CDS An11g02350 84592225 complement(join(575982..576094,576118..576157,576200..576606,576724..576818,576895..576952,577336..577399)) VII 1 NT_166526.1 hypothetical protein 577399 84592225 An11g02350 Aspergillus niger hypothetical protein XP_059601546.1 575982 R 5061 CDS An11g02360 4984465 complement(join(580962..581006,581072..581398,581454..581591,581642..582290,582345..582634,582696..582779,582833..582926,583010..583058,583123..583140,583203..583212)) VII 1 NT_166526.1 Complex: hetero-oligomeric complex of about 850 to 900 kd that forms two stacked rings, 12 to 16 nm in diameter.; Function: CCT5 from H. sapiens assist the folding of proteins upon atp hydrolysis and is known to play a role in the folding of actin and tubulin in vitro.; Similarity: belongs to the tcp-1 chaperonin family.; Title: strong similarity to T-complex protein 1 epsilon subunit CCT5 - Homo sapiens; cytoplasm; See PMID 7788527; uncharacterized protein 583212 4984465 An11g02360 Aspergillus niger uncharacterized protein XP_059601547.1 580962 R 5061 CDS An11g02365 84592226 complement(join(585090..585944,586003..586243,586354..586406)) VII 1 NT_166526.1 Title: weak similarity to TRF2-interacting telomeric protein RAP1 - Homo sapiens; uncharacterized protein 586406 84592226 An11g02365 Aspergillus niger uncharacterized protein XP_059601548.1 585090 R 5061 CDS An11g02370 4984467 join(587178..587266,587320..587473,587525..587558,587598..588508,588570..588603,588788..588986,589096..591643) VII 1 NT_166526.1 Function: the function of CTR86 of S. cerevisiae is not yet clear, but the fact that the upstream region contains a GCN4 responsive site suggests that the gene product may also be involved in amino acid biosynthesis.; Similarity: the ORF is much longer than the yeast protein (1322 compared to 563 amino acids).; Similarity: the ORF shows similarity to the yeast protein over a C-terminal stretch of about 100 amino acids.; Title: similarity to hypothetical protein Ctr86 -Saccharomyces cerevisiae; See PMID 2204248; uncharacterized protein 591643 4984467 An11g02370 Aspergillus niger uncharacterized protein XP_059601549.1 587178 D 5061 CDS An11g02380 4984468 complement(join(598875..598901,598959..600128,600245..600301,600367..600426)) VII 1 NT_166526.1 Catalytic activity: GTP + alpha-D-Mannose 1-phosphate = Pyrophosphate + GDPmannose.; Function: MPG1 of H. jecorina is involved in the early steps of protein glycosylation.; Function: Mpg1 from H. jecorina was cloned as supressor of the S. cerevisiae mutation in the DPM1 gene encoding mannosylphosphodolichol synthase.; Function: overexpression of Mpg1 in H. jecorina gene also increased the transcription of the dpm1 gene and DPMS activity.; Function: overexpression of Mpg1 in H. jecorina led to a twofold increase in GDP-mannose (GDPMan) levels.; Remark: Hypocrea jecorina is also called Trichoderma reesei.; Title: strong similarity to GTP:alpha-D-mannose-1-phosphate guanylyltransferase MPG1 -Hypocrea jecorina; See PMID 9644208; See PMID 12902219; uncharacterized protein 600426 4984468 An11g02380 Aspergillus niger uncharacterized protein XP_001394240.1 598875 R 5061 CDS An11g02390 4984469 join(601173..601516,601679..602604,602788..603260,603317..603458,603537..603712) VII 1 NT_166526.1 Function: Mx proteins are members of a family of interferon-inducible genes expressed when cells are treated with double-stranded RNA or virus infection. They are GTPases with an antiviral activity.; Title: strong similarity to antiviral determinants Mx1 - Rattus norvegicus; See PMID 2173790; See PMID 7507812; uncharacterized protein 603712 4984469 An11g02390 Aspergillus niger uncharacterized protein XP_059605451.1 601173 D 5061 CDS An11g02400 4984470 join(604325..604540,604650..606237,606293..606345) VII 1 NT_166526.1 Catalytic activity: ATP + L-lysine + tRNA(Lys) <=> AMP + diphosphate + L-lysyl-tRNA(Lys).; Remark: alternate names for S. cerevisiae Krs1: GCD5 or YDR037W.; Title: strong similarity to cytosolic lysine--tRNA ligase Krs1 - Saccharomyces cerevisiae; cytoplasm; See PMID 2903861; See PMID 8952483; uncharacterized protein 606345 4984470 An11g02400 Aspergillus niger uncharacterized protein XP_059605452.1 604325 D 5061 CDS An11g02420 84592227 join(608325..608946,609002..609126) VII 1 NT_166526.1 Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: weak similarity to viral protein EBNA-1 -EpsteinBarr virus TsBB6; uncharacterized protein 609126 84592227 An11g02420 Aspergillus niger uncharacterized protein XP_059605453.1 608325 D 5061 CDS An11g02430 4984473 complement(join(609618..610731,610791..611194)) VII 1 NT_166526.1 Function: the Cox15 protein from S. cerevisiae is required for the assembly of yeast cytochrome c oxidase.; Remark: alternate name for S. cerevisiae Cox15: YER141w.; Similarity: the ORF encoded protein shows also strong similarity to the human secreted protein described in patent WO9926973-A1.; Title: strong similarity to assembly factor of cytochrome c oxidase Cox15 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9228094; uncharacterized protein 611194 4984473 An11g02430 Aspergillus niger uncharacterized protein XP_001394244.1 609618 R 5061 CDS An11g02440 4984474 join(612676..613009,613067..613242,613280..613840,613893..614478,614539..615848) VII 1 NT_166526.1 Title: strong similarity to hypothetical secreted protein SCF41.31c - Streptomyces coelicolor; uncharacterized protein 615848 4984474 An11g02440 Aspergillus niger uncharacterized protein XP_059605454.1 612676 D 5061 CDS An11g02450 4984475 complement(616030..616992) VII 1 NT_166526.1 Function: the EryBIV aldohexose 4-ketoreductases is part of the eryB gene cluster from S. erythraea which is involved in the L-mycarose biosynthesis.; Pathway: the eryA (polyketide synthase genes), eryB (L-mycarose biosynthesis genes) and the eryC (D-desosamine biosynthesis genes) gene clusters from S. erythraea are involved in the erythromycin biosynthetic pathway.; Remark: the EryBIV aldohexose 4-ketoreductase from S. erythraea is identical to the protein described in patent WO9905283-A2.; Similarity: the ORF encoded protein shows strong similarity to the hypothetical proteins YLL056c from S. cerevisiae and SPBC2A9. 02 from S. pombe.; Title: similarity to aldohexose 4-ketoreductase EryBIV - Saccharopolyspora erythraea; See PMID 9353926; See PMID 9393448; See PMID 9563840; uncharacterized protein 616992 4984475 An11g02450 Aspergillus niger uncharacterized protein XP_001394246.1 616030 R 5061 CDS An11g02460 4984476 complement(join(617422..617493,617554..617653,617708..618242,618319..618361)) VII 1 NT_166526.1 Function: the nor-1 gene is involved in aflatoxin biosynthesis in Aspergillus parasiticus. Recombinant Nor-1 expressed in Escherichia coli converted the 1' keto group of norsolorinic acid to the 1' hydroxyl group of averantin in crude E. coli cell extracts in the presence of NADPH.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Title: strong similarity to norsolorinic acid ketoreductase nor-1 - Aspergillus parasiticus; See PMID 10584035; See PMID 7993094; uncharacterized protein 618361 4984476 An11g02460 Aspergillus niger uncharacterized protein XP_001394247.1 617422 R 5061 CDS An11g02470 4984477 join(619886..619930,620061..620141,620180..620332,620499..621081,621131..621214,621265..622022) VII 1 NT_166526.1 Remark: the ORF encoded protein is N-terminally extended in comparison to all other matching homologs.; Title: similarity to hypothetical protein F27J15.2 -Arabidopsis thaliana; uncharacterized protein 622022 4984477 An11g02470 Aspergillus niger uncharacterized protein XP_001394248.3 619886 D 5061 CDS An11g02480 4984478 complement(join(622227..622703,622760..623130,623251..623459,623532..623833)) VII 1 NT_166526.1 Catalytic activity: salicylate + NADH + O2 = catechol + NAD+ + H2O + CO2.; Function: nahG of P. stutzeri catalyzes the formation of catechol from salicylate, a key intermediate in naphthalene catabolism.; Induction: nahG of P. stutzeri is induced and expressed upon incubation with salicylate.; Pathway: nahpthalene, salicylate, and phenylalanine metabolism.; Title: strong similarity to salicylate hydroxylase nahW - Pseudomonas stutzeri; See PMID 10197990; uncharacterized protein 623833 4984478 An11g02480 Aspergillus niger uncharacterized protein XP_059605455.1 622227 R 5061 CDS An11g02490 4984479 complement(join(624507..624720,624774..624892,624971..625291)) VII 1 NT_166526.1 Title: weak similarity to endocarditis specific antigen region from patent WO9520658-A2 - Streptococcus oralis; uncharacterized protein 625291 4984479 An11g02490 Aspergillus niger uncharacterized protein XP_059605456.1 624507 R 5061 CDS An11g02500 4984480 join(625915..626241,626288..626640,626709..627036) VII 1 NT_166526.1 Catalytic activity: Dimethylallyl diphosphate + isopentenyl diphosphate <=> diphosphate + geranyl diphosphate.; Catalytic activity: the human GGPPS enzyme also catalyzes: geranyl diphosphate + isopentenyl diphosphate <=> diphosphate + trans,trans-farnesyl diphosphate.; Catalytic activity: the human GGPPS enzyme also catalyzes: trans-trans-farnesyl diphosphate + isopentenyl diphosphate <=> diphosphate + geranylgeranyl diphosphate.; Function: the human GGPPS enzyme catalyzes the trans-addition of the three molecules of IPP (isopentenyl diphosphate) onto DMAPP(dimethylallyl diphosphate) to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylatedgeranylated proteins.; Title: strong similarity to geranylgeranyl pyrophosphate synthase GGPPS - Homo sapiens; See PMID 10026212; uncharacterized protein 627036 4984480 An11g02500 Aspergillus niger uncharacterized protein XP_001394251.1 625915 D 5061 CDS An11g02510 4984481 join(627789..628218,628250..628429,628484..628815,628879..629430) VII 1 NT_166526.1 Pathway: the cytochrome P450 monooxygenase TRI4 from M. roridum is involved in the biosynthesis of trichothecenes, which are toxic sesquiterpenoids produced by certain fungi and plants.; Remark: the M. roridum TRI4 gene can successfully complement a F. sporotrichioides TRI4-mutant.; Title: similarity to cytochrome P450 monooxygenase TRI4 - Myrothecium roridum; See PMID 9529523; uncharacterized protein 629430 4984481 An11g02510 Aspergillus niger uncharacterized protein XP_059605457.1 627789 D 5061 CDS An11g02520 4984482 join(629926..630087,630369..631118,631179..631661,631734..631909,631962..632220) VII 1 NT_166526.1 Catalytic activity: S-adenosyl-L-methionine + G(5')PPPR-RNA <=> S-adenosyl-L-homocysteine + m7G(5')PPPR-RNA.; Function: CaAbd1 from C. albicans transfers a methyl group from S-adenosylmethionine to the N7 position of guanine of the mRNA cap.; Remark: CaAbd1 expressed as a fusion with glutathione S-transferase (GST) displayed cap MTase activity in vitro. it also rescued S. cerevisiae abd1delta null mutants.; Title: strong similarity to mRNAcap-guanine-N7-methyltransferase CaAbd1 - Candida albicans; See PMID 10589710; uncharacterized protein 632220 4984482 An11g02520 Aspergillus niger uncharacterized protein XP_059605458.1 629926 D 5061 CDS An11g02530 4984483 join(632627..633342,633444..634326) VII 1 NT_166526.1 Title: similarity to hypothetical protein CAF06139.1 - Neurospora crassa; uncharacterized protein 634326 4984483 An11g02530 Aspergillus niger uncharacterized protein XP_001394254.1 632627 D 5061 CDS An11g02540 4984484 complement(634714..635679) VII 1 NT_166526.1 Function: the recombinant mitochondrial 2-oxoglutarate/malate translocator (clone OMT103) from Panicum miliaceum reconstituted in liposomes efficiently transported malate, citrate, and 2-oxoglutarate.; Title: strong similarity to mitochondrial 2-oxoglutarate/malate translocator clone OMT103 - Panicum miliaceum; localisation:mitochondrion; See PMID 8616243; uncharacterized protein 635679 4984484 An11g02540 Aspergillus niger uncharacterized protein XP_059605459.1 634714 R 5061 CDS An11g02550 4984485 complement(join(640286..641629,641954..642154,642202..642277,642428..642609)) VII 1 NT_166526.1 Catalytic activity: ATP + oxaloacetate <=> ADP + phosphoenolpyruvate + CO(2). -; Complex: Homotetramer.; Pathway: the phosphoenolpyruvate carboxykinase(KlPck1 K. lac. or Pck1 S. cer.) is the rate-limiting gluconeogenic enzyme.; Remark: the KlPCK1 gene from K. lactis restored PEPCK activity in a pck1 mutant of S. cerevisiae.; Similarity: the ORF encoded protein shows also strong similarity to the phosphoenolpyruvate carboxykinase from Z. japonica described in patent JP09065886-A.; Title: strong similarity to phosphoenolpyruvate carboxykinase KlPck1 - Kluyveromyces lactis; See PMID 9717242; uncharacterized protein 642609 4984485 An11g02550 Aspergillus niger uncharacterized protein XP_001394256.1 640286 R 5061 CDS An11g02560 84592228 complement(join(646465..646666,646881..>646918)) VII 1 NT_166526.1 Remark: N-terminally truncated ORF due to the end of contig.; hypothetical protein [truncated ORF] 646918 84592228 An11g02560 Aspergillus niger hypothetical protein [truncated ORF] XP_059605460.1 646465 R 5061 CDS An11g02570 84592229 join(<647019..647058,647185..647297,647332..647457) VII 1 NT_166526.1 hypothetical protein [truncated ORF] 647457 84592229 An11g02570 Aspergillus niger hypothetical protein [truncated ORF] XP_059601550.1 647019 D 5061 CDS An11g02580 4984488 complement(join(647575..647939,647996..648097,648149..648998,649040..649213,649261..649367,649546..649560,649926..650055)) VII 1 NT_166526.1 Remark: The C. albicans CNH1 gene is able to functionally complement the salt-sensitivity of a S. cerevisiae ena1 nha1 mutant.; Title: strong similarity to Na+/H+ antiporter Cnh1 -Candida albicans; plasma membrane; See PMID 10832630; uncharacterized protein 650055 4984488 An11g02580 Aspergillus niger uncharacterized protein XP_059601551.1 647575 R 5061 CDS An11g02590 4984489 complement(join(650974..651136,651203..651680,651823..651889)) VII 1 NT_166526.1 Title: strong similarity to peroxisomal membrane protein Pmp27 - Saccharomyces cerevisiae; See PMID 7721939; See PMID 7860627; See PMID 8553699; uncharacterized protein 651889 4984489 An11g02590 Aspergillus niger uncharacterized protein XP_001394260.1 650974 R 5061 CDS An11g02600 4984490 complement(join(652781..652873,652931..653201,653257..653567,653620..653638,653696..654294,654362..654535)) VII 1 NT_166526.1 Remark: PT2 expression in S. cerevisiae complements the pho84 mutant phenotype.; Title: strong similarity to PT2/PHT4 Phosphate transporter - Arabidopsis thaliana; plasma membrane; See PMID 9872450; See PMID 8927627; uncharacterized protein 654535 4984490 An11g02600 Aspergillus niger uncharacterized protein XP_001394261.1 652781 R 5061 CDS An11g02610 4984491 join(656522..656968,657057..657883,657939..658131) VII 1 NT_166526.1 Complex: the S. cerevisiae homolog Rpn7p is subunit of the 19S proteasome regulatory subunit.; Title: strong similarity to proteasome 19S regulatory particle subunit Rpn7 - Saccharomyces cerevisiae; uncharacterized protein 658131 4984491 An11g02610 Aspergillus niger uncharacterized protein XP_001394262.1 656522 D 5061 CDS An11g02620 4984492 join(658954..659107,659355..660595,660654..660904,661057..661114) VII 1 NT_166526.1 Catalytic activity: L-alanine + 2-oxoglutarate <=> pyruvate + L-glutamate.; Function: the H. vulgare homolog ALA2 encodes a hypoxically inducible alanine aminotransferase.; Title: strong similarity to alanine transaminase ALA2 - Hordeum vulgare; See PMID 8123785; uncharacterized protein 661114 4984492 An11g02620 Aspergillus niger uncharacterized protein XP_001394263.3 658954 D 5061 CDS An11g02630 4984493 join(662255..662461,662565..664148) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein SPCC1235.03 - Schizosaccharomyces pombe; uncharacterized protein 664148 4984493 An11g02630 Aspergillus niger uncharacterized protein XP_001394264.3 662255 D 5061 CDS An11g02640 4984494 join(664607..664850,664957..665318) VII 1 NT_166526.1 Function: catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. -; Title: strong similarity to peptide methionine sulfoxide reductase MSRA - Streptococcus pneumoniae; See PMID 7934910; See PMID 8755589; uncharacterized protein 665318 4984494 An11g02640 Aspergillus niger uncharacterized protein XP_001394265.1 664607 D 5061 CDS An11g02650 4984495 join(665697..665805,665927..666095,666154..666198,666268..666370,666429..667730) VII 1 NT_166526.1 Title: strong similarity to hypothetical gtpase activating protein SPAC824.09c - Schizosaccharomyces pombe; uncharacterized protein 667730 4984495 An11g02650 Aspergillus niger uncharacterized protein XP_001394266.1 665697 D 5061 CDS An11g02660 4984496 join(668536..668607,668638..669003,669072..669545,669601..670872) VII 1 NT_166526.1 Remark: facB of A. niger encodes a Zn(II)2Cys6 transcriptional activator.; Remark: the facB gene from A. niger is similar to the facB gene from A. nidulans, which is a major regulatory gene involved in acetamide and acetate utilisation.; Title: similarity to hypothetical acetate regulatory DNA binding protein facB - Aspergillus niger; uncharacterized protein 670872 4984496 An11g02660 Aspergillus niger uncharacterized protein XP_059601552.1 668536 D 5061 CDS An11g02670 4984497 complement(join(671697..673552,673612..673938,674011..674044)) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein SPBC1703.02 - Schizosaccharomyces pombe; uncharacterized protein 674044 4984497 An11g02670 Aspergillus niger uncharacterized protein XP_001394268.1 671697 R 5061 CDS An11g02680 4984498 join(675328..675549,675798..676056,676131..676483,676588..677014,677105..677125,677235..677302) VII 1 NT_166526.1 Title: similarity to proteophosphoglycan ppg1 -Leishmania major; plasma membrane; See PMID 10531342; uncharacterized protein 677302 4984498 An11g02680 Aspergillus niger uncharacterized protein XP_059601553.1 675328 D 5061 CDS An11g02690 4984499 complement(join(677450..678902,678963..679155,679212..679456,679523..679635,679718..680125)) VII 1 NT_166526.1 Function: the facB gene of Aspergillus nidulans is a major regulatory gene involved in acetamide and acetate utilisation-; Remark: facB of Aspergillus nidulans encodes a Zn(II)2Cys6 transcriptional activator.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; See PMID 9197408; uncharacterized protein 680125 4984499 An11g02690 Aspergillus niger uncharacterized protein XP_001394270.1 677450 R 5061 CDS An11g02700 4984500 join(686515..686590,686663..686836,686893..688234,688621..688879,688921..688952,689061..689106,689180..689209) VII 1 NT_166526.1 Function: Haa1 of S. cerevisiae regulates the transcription of a set of yeast genes, many of which encode membrane proteins.; Localization: Haa1 is located in the nucleus.; Remark: synonyms for Haa1 of S. cerevisiae are YPR008w and CAA88786. 1.; Title: similarity to transcriptional activator Haa1 - Saccharomyces cerevisiae; See PMID 11504737; uncharacterized protein 689209 4984500 An11g02700 Aspergillus niger uncharacterized protein XP_001394271.3 686515 D 5061 CDS An11g02720 84592230 complement(<690534..>691935) VII 1 NT_166526.1 Title: similarity to hypothetical protein C50F7.2 -Caenorhabditis elegans; uncharacterized protein 691935 84592230 An11g02720 Aspergillus niger uncharacterized protein XP_059606316.1 690534 R 5061 CDS An11g02730 4984503 join(695781..695835,695883..695970,696029..696160,696231..696538,696603..696745) VII 1 NT_166526.1 Title: similarity to hypothetical serine-rich protein SPCC1322.10 - Schizosaccharomyces pombe; uncharacterized protein 696745 4984503 An11g02730 Aspergillus niger uncharacterized protein XP_059606317.1 695781 D 5061 CDS An11g02740 84592231 join(697722..697807,697854..697891,698116..698132) VII 1 NT_166526.1 hypothetical protein 698132 84592231 An11g02740 Aspergillus niger hypothetical protein XP_059606318.1 697722 D 5061 CDS An11g02750 4984505 complement(join(698518..698639,698717..698792,698854..699051,699104..699389,699455..700400,700485..700627,700824..700828)) VII 1 NT_166526.1 Function: creC of A. nidulans is involved in carbon catabolite repression.; Similarity: the creC gene of A. nidulans was cloned and found to encode a protein which contains five WD40 motifs.; Title: strong similarity to hypothetical protein involved in carbon catabolite repression creC - Aspergillus nidulans; See PMID 10852476; uncharacterized protein 700828 4984505 An11g02750 Aspergillus niger uncharacterized protein XP_001394276.1 698518 R 5061 CDS An11g02760 4984506 complement(join(701713..703604,703660..703669)) VII 1 NT_166526.1 Similarity: shows similarity to several known ras-related GTPases,; Title: strong similarity to protein involved in vesicle transport in the secretory pathway YAL048c -Saccharomyces cerevisiae; See PMID 10860831; See PMID 10949581; See PMID 10220001; uncharacterized protein 703669 4984506 An11g02760 Aspergillus niger uncharacterized protein XP_001394277.1 701713 R 5061 CDS An11g02770 4984507 join(704468..704510,704592..704695,704765..705831,705899..705920) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein CAB62422.1 - Schizosaccharomyces pombe; See PMID 1372395; See PMID 7802869; See PMID 8479540; uncharacterized protein 705920 4984507 An11g02770 Aspergillus niger uncharacterized protein XP_001394278.1 704468 D 5061 CDS An11g02780 4984508 join(708490..708495,708734..711136,711199..711411) VII 1 NT_166526.1 Function: Zds2 from S. cerevisiae is a multicopy suppressor of a sin4 defect.; Remark: alternate names for Zds2 from S. cerevisiae are Ces4 and Yml109w.; Title: weak similarity to multicopy suppressor Zds2 - Saccharomyces cerevisiae; See PMID 8816438; See PMID 10398844; uncharacterized protein 711411 4984508 An11g02780 Aspergillus niger uncharacterized protein XP_059606319.1 708490 D 5061 CDS An11g02785 4984509 join(712272..712297,712387..712495,712623..712781) VII 1 NT_166526.1 Title: strong similarity to hypothetical SNARE protein - Schizosaccharomyces pombe; uncharacterized protein 712781 4984509 An11g02785 Aspergillus niger uncharacterized protein XP_001394280.1 712272 D 5061 CDS An11g02790 84592232 complement(join(712965..713062,713256..713295)) VII 1 NT_166526.1 hypothetical protein 713295 84592232 An11g02790 Aspergillus niger hypothetical protein XP_059606320.1 712965 R 5061 CDS An11g02810 84592233 complement(join(715773..715847,715941..715977,716080..716141)) VII 1 NT_166526.1 hypothetical protein 716141 84592233 An11g02810 Aspergillus niger hypothetical protein XP_059606321.1 715773 R 5061 CDS An11g02830 4984513 join(<722397..722669,722729..723157,723216..724052) VII 1 NT_166526.1 Remark: Overproduction of Rod1p leads to resistance to not only o-DNB but also zinc and calcium. N-terminus truncated due to end of contig.; Title: similarity to resistance to o-dinitrobenzene protein Rod1 - Saccharomyces cerevisiae [truncated ORF]; See PMID 8621680; uncharacterized protein 724052 4984513 An11g02830 Aspergillus niger uncharacterized protein XP_001394284.3 722397 D 5061 CDS An11g02840 4984514 join(725636..725761,725828..725953,726016..726123,726178..727335) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein SPAC637.13c - Schizosaccharomyces pombe; uncharacterized protein 727335 4984514 An11g02840 Aspergillus niger uncharacterized protein XP_059601554.1 725636 D 5061 CDS An11g02850 4984515 complement(join(728028..728643,728700..729094)) VII 1 NT_166526.1 hypothetical protein 729094 4984515 An11g02850 Aspergillus niger hypothetical protein XP_001394286.1 728028 R 5061 CDS An11g02855 84592234 complement(join(729971..730004,730073..730305)) VII 1 NT_166526.1 hypothetical protein 730305 84592234 An11g02855 Aspergillus niger hypothetical protein XP_059601555.1 729971 R 5061 CDS An11g02860 4984517 join(730572..730605,730671..730715,730775..731485,731574..731749) VII 1 NT_166526.1 Catalytic activity: (R)-S-lactoylglutathione <=> glutathione + methylglyoxal.; Function: the S. cerevisiae homolog GLO1 encodes glyoxalase I which is required for detoxification of methylglyoxal.; Remark: the S. cerevisiae homolog Glo1p is regulated by the HOG (high osmolarity glycerol)-MAP (mitogen-activated protein) kinase pathway in osmotic stress response.; Title: strong similarity to glyoxalase I Glo1 -Saccharomyces cerevisiae; See PMID 9446611; See PMID 8824231; uncharacterized protein 731749 4984517 An11g02860 Aspergillus niger uncharacterized protein XP_059601556.1 730572 D 5061 CDS An11g02870 4984518 join(732284..732370,732447..732529,732658..733707,733758..733966,734017..734149,734209..734433,734485..734640,734703..735567) VII 1 NT_166526.1 Remark: The niaD and niiA genes of Aspergillus nidulans genes are under the control of the positively acting nirA transcription factor, which mediates nitrate induction.; Title: similarity to nitrate assimilation regulatory protein nirA - Aspergillus nidulans; nucleus; See PMID 10075929; See PMID 1922075; See PMID 7565720; uncharacterized protein 735567 4984518 An11g02870 Aspergillus niger uncharacterized protein XP_059601557.1 732284 D 5061 CDS An11g02880 84592235 complement(join(735675..735816,735961..736040,736125..736308,736362..736504)) VII 1 NT_166526.1 hypothetical protein 736504 84592235 An11g02880 Aspergillus niger hypothetical protein XP_059601558.1 735675 R 5061 CDS An11g02890 84592236 complement(736819..737448) VII 1 NT_166526.1 Title: weak similarity to hypothetical protein encoded by An09g01250 - Aspergillus niger; uncharacterized protein 737448 84592236 An11g02890 Aspergillus niger uncharacterized protein XP_059601559.1 736819 R 5061 CDS An11g02900 4984521 join(737989..738167,738285..738383,738479..738730,738813..740019) VII 1 NT_166526.1 hypothetical protein 740019 4984521 An11g02900 Aspergillus niger hypothetical protein XP_059601560.1 737989 D 5061 CDS An11g02910 84592237 complement(join(740216..740353,740415..740546,740616..740633)) VII 1 NT_166526.1 Remark: The weak similarity to caldesmon is only based on repetitive sequences.; hypothetical protein 740633 84592237 An11g02910 Aspergillus niger hypothetical protein XP_059601561.1 740216 R 5061 CDS An11g02920 4984523 complement(join(740936..741112,741200..742173,742270..742539,742611..742758)) VII 1 NT_166526.1 Title: similarity to hypothetical protein encoded by An09g01520 - Aspergillus niger; uncharacterized protein 742758 4984523 An11g02920 Aspergillus niger uncharacterized protein XP_001394294.3 740936 R 5061 CDS An11g02930 84592238 complement(join(743199..743297,743495..743569,743615..743650)) VII 1 NT_166526.1 hypothetical protein 743650 84592238 An11g02930 Aspergillus niger hypothetical protein XP_059601562.1 743199 R 5061 CDS An11g02940 4984525 complement(join(744104..744215,744297..744700)) VII 1 NT_166526.1 Title: weak similarity to hypothetical protein encoded by An09g01510 - Aspergillus niger; uncharacterized protein 744700 4984525 An11g02940 Aspergillus niger uncharacterized protein XP_001394296.1 744104 R 5061 CDS An11g02950 4984526 complement(join(745645..746862,746910..747015,747064..747324,747374..747506,747594..747638,747699..747885,747960..748391)) VII 1 NT_166526.1 Function: calpains are calcium-activated non-lysosomal thiol-proteases. Calpains show preferential cleavage: Lyr-|-xaa, Met-|-xaa or Arg-|-xaa with Leu or Val as the P2 residue.; Similarity: the ORF encoded protein belongs to the peptidase family C2, also known as the calpain family of thiol proteases.; Title: similarity to calpain nCL-3 from patent DE19650142-A1 - Mus musculus; deleted EC_number 3.4.22.17; uncharacterized protein 748391 4984526 An11g02950 Aspergillus niger uncharacterized protein XP_059601563.1 745645 R 5061 CDS An11g02960 4984527 complement(join(749684..749945,750005..750168,750221..750729,750837..750873)) VII 1 NT_166526.1 Catalytic activity: ATP + a protein <=> ADP + a phosphoprotein.; Complex: the E. nidulans NimX kinase forms a stable but non-covalent complex with a regulatory subunit (Suc1) and with a cyclin.; Remark: the Emericella nidulans NimX kinase is able to complement the Schizosaccharomyces pombe cdc2-33 mutation.; Similarity: NimX from E. nidulans belongs to the Ser/Thr family of protein kinases and the Cdc2/CdkX subfamily.; Title: strong similarity to protein kinase functional homolog of cdc2 nimX - Aspergillus nidulans; deleted EC_number 2.7.1.37; See PMID 10601021; See PMID 7962194; uncharacterized protein 750873 4984527 An11g02960 Aspergillus niger uncharacterized protein XP_001394298.1 749684 R 5061 CDS An11g02970 4984528 join(751585..751873,751933..752726) VII 1 NT_166526.1 Function: the human ABH protein is probably involved in the repair of alkylated DNA. It provides resistance to alkylating agents. When human ABH was expressed in E. coli alkB mutant cells partial rescue of the cells from MMS-induced cell death occurred.; Title: similarity to DNA alkylation damage repair protein and AlkB homolog ABH - Homo sapiens; See PMID 8600462; uncharacterized protein 752726 4984528 An11g02970 Aspergillus niger uncharacterized protein XP_001394299.1 751585 D 5061 CDS An11g02980 4984529 join(753624..753899,753955..754779,754826..754873,754932..755352,755479..755603) VII 1 NT_166526.1 Catalytic activity: a monocarboxylic acid amide + H(2)O <=> a monocarboxylate + NH(3).; Function: the AmdS acetamidase allows Aspergillus oryzae acetamide to use as a sole carbon or nitrogen source.; Similarity: the ORF encoded protein is identical to the internal consensus fragment of the A. niger acetamidase described in patent EP758020-A2.; Title: strong similarity to acetamidase amdS -Aspergillus oryzae; See PMID 1840550; uncharacterized protein 755603 4984529 An11g02980 Aspergillus niger uncharacterized protein XP_001394300.1 753624 D 5061 CDS An11g02990 4984530 complement(join(755752..756918,756985..757260,757296..757505)) VII 1 NT_166526.1 Remark: astaxanthin is a ketocarotenoids employed for food coloration.; Similarity: the ORF encoded protein belongs to the cytochrome P450 family.; Title: strong similarity to astaxanthin synthetase from patent EP1035206 - Phaffia rhodozyma; uncharacterized protein 757505 4984530 An11g02990 Aspergillus niger uncharacterized protein XP_059601564.1 755752 R 5061 CDS An11g03000 4984531 complement(join(757936..758054,758241..758268,758320..758520,758729..760337,760430..760632,760684..761235,761288..761467,761647..761880)) VII 1 NT_166526.1 Title: strong similarity to carnosinase 2 polypeptide HC2 from patent EP1122307-A1 - Homo sapiens; uncharacterized protein 761880 4984531 An11g03000 Aspergillus niger uncharacterized protein XP_059601565.1 757936 R 5061 CDS An11g03010 84592239 join(762077..762320,762391..762642,762690..762889) VII 1 NT_166526.1 hypothetical protein 762889 84592239 An11g03010 Aspergillus niger hypothetical protein XP_059601566.1 762077 D 5061 CDS An11g03020 84592240 complement(join(763202..763315,763417..763546,763633..763718)) VII 1 NT_166526.1 Title: weak similarity to platenolide synthase ORF3 protein from patent EP791656-A2 - Streptomyces ambofaciens; uncharacterized protein 763718 84592240 An11g03020 Aspergillus niger uncharacterized protein XP_059601567.1 763202 R 5061 CDS An11g03030 84592241 complement(join(763772..763860,763940..763979,764019..764107,764198..764248,764343..764475)) VII 1 NT_166526.1 hypothetical protein 764475 84592241 An11g03030 Aspergillus niger hypothetical protein XP_059601568.1 763772 R 5061 CDS An11g03040 4984535 join(764477..764536,764600..>765669) VII 1 NT_166526.1 Remark: C-terminally truncated ORF due to the end of contig.; Title: weak similarity to hypothetical drebrin E2 -Mus musculus [truncated ORF]; uncharacterized protein 765669 4984535 An11g03040 Aspergillus niger uncharacterized protein XP_001394306.3 764477 D 5061 CDS An11g03050 4984536 complement(join(<765770..766264,766409..766945,767147..768539)) VII 1 NT_166526.1 Remark: C-terminally truncated ORF due to the end of contig.; Similarity: the ORF DNA sequence is strong similar to the EST an_3239 from Aspergillus niger .; Similarity: the similarities of the ORF encoded protein to all matches with an e-val less than 1e-05 are mainly based on repetitive structures.; Title: strong similarity to hypothetical protein SPBC13G1.05 - Schizosaccharomyces pombe [truncated ORF]; uncharacterized protein 768539 4984536 An11g03050 Aspergillus niger uncharacterized protein XP_059601569.1 765770 R 5061 CDS An11g03060 4984537 complement(join(769171..769461,769529..769899,769972..770240,770298..770599)) VII 1 NT_166526.1 Catalytic activity: salicylate + NADH + O(2) <=> catechol + NAD(+) + H(2)O + CO(2).; Cofactor: FAD.; Title: strong similarity to salicylate hydroxylase sal - Pseudomonas putida; See PMID 2916843; See PMID 10920265; uncharacterized protein 770599 4984537 An11g03060 Aspergillus niger uncharacterized protein XP_001394308.3 769171 R 5061 CDS An11g03070 4984538 complement(join(771241..771711,771868..772272,772470..772506,772579..772809,772936..773162,773200..773202)) VII 1 NT_166526.1 Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: weak similarity to chitinase chiA -Aspergillus nidulans; uncharacterized protein 773202 4984538 An11g03070 Aspergillus niger uncharacterized protein XP_059601570.1 771241 R 5061 CDS An11g03080 84592242 complement(join(773876..773914,774000..774074,774116..774230,774308..774569,774686..774710)) VII 1 NT_166526.1 hypothetical protein 774710 84592242 An11g03080 Aspergillus niger hypothetical protein XP_059601571.1 773876 R 5061 CDS An11g03090 4984540 join(774712..774872,774905..775004,775171..775544,775601..775671,775733..775995) VII 1 NT_166526.1 Function: Pth11 from M. grisea is involved in surface dependent signal transduction during plant infection. Pth11 can activate appressorium differentiation in response to inductive surface cues and repress differentiation on poorly inductive surfaces.; Remark: the filamentous ascomycete Magnaporthe grisea is the blast pathogen of many grass species,including rice.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529; uncharacterized protein 775995 4984540 An11g03090 Aspergillus niger uncharacterized protein XP_059601572.1 774712 D 5061 CDS An11g03100 4984541 complement(join(776522..777382,777446..777469,777531..777572)) VII 1 NT_166526.1 Catalytic activity: ATP + a protein <=> ADP + a phosphoprotein.; Function: the E. nidulans kinase PHOA is proposed to function to help integrate environmental signals with developmental decisions to allow ordered differentiation of specific cell types in E. nidulans under varying growth conditions.; Title: strong similarity to cyclin-dependent protein kinase phoa - Aspergillus nidulans; deleted EC_number 2.7.1.37; See PMID 9670015; uncharacterized protein 777572 4984541 An11g03100 Aspergillus niger uncharacterized protein XP_001394312.1 776522 R 5061 CDS An11g03110 4984542 join(778493..778911,778959..779017,779065..780071) VII 1 NT_166526.1 Catalytic activity: Methanol + NAD(+) <=> formaldehyde + NADH.; Function: the methanol dehydrogenase Mdh from B. methanolicus C1 catalyzes the reversible oxidation of methanol to formaldehyde using NAD+.; Similarity: the methanol dehydrogenase Mdh from B. methanolicus C1 belongs to the iron-containing alcohol dehydrogenase family.; Title: strong similarity to methanol dehydrogenase Mdh - Bacillus methanolicus; See PMID 1644761; uncharacterized protein 780071 4984542 An11g03110 Aspergillus niger uncharacterized protein XP_001394313.1 778493 D 5061 CDS An11g03120 4984543 join(780433..781088,781175..781475) VII 1 NT_166526.1 Function: XynD from Bacillus polymyxa catalyzes the hydrolysis of 1,4-beta-xylosidic linkages in xylans.; Similarity: XynD from Bacillus polymyxa belongs to family 43 of glycosyl hydrolases.; Title: similarity to endo-1,4-beta-xylanase XynD -Bacillus polymyxa; See PMID 1938968; uncharacterized protein 781475 4984543 An11g03120 Aspergillus niger uncharacterized protein XP_001394314.1 780433 D 5061 CDS An11g03130 4984544 782289..783275 VII 1 NT_166526.1 Title: weak similarity to hypothetical protein encoded by An01g07840 - Aspergillus niger; uncharacterized protein 783275 4984544 An11g03130 Aspergillus niger uncharacterized protein XP_001394315.1 782289 D 5061 CDS An11g03140 84592243 join(784830..784843,784985..785050,785352..785549,785593..785639,785819..785931,785963..786239,786279..786424) VII 1 NT_166526.1 hypothetical protein 786424 84592243 An11g03140 Aspergillus niger hypothetical protein XP_059599556.1 784830 D 5061 CDS An11g03150 4984546 join(787550..787615,787668..787725,787780..788515,788565..788896,788952..788995) VII 1 NT_166526.1 Catalytic activity: salicylate + NADH + O(2) <=> catechol + NAD(+) + H(2)O + CO(2).; Cofactor: FAD.; Pathway: nahpthalene catabolism and phenylalanine metabolism.; Similarity: the ORF encoded protein shows also strong similarity to the 6-hydroxynicotinic acid mono-oxygenase from Pseudomonas fluorescens strain TN5 described in patent JP09121864-A.; Title: strong similarity to salicylate hydroxylase nahG - Pseudomonas putida; See PMID 1993181; See PMID 2363715; uncharacterized protein 788995 4984546 An11g03150 Aspergillus niger uncharacterized protein XP_059599557.1 787550 D 5061 CDS An11g03160 4984547 complement(join(789984..791344,791421..791442)) VII 1 NT_166526.1 Title: weak similarity to hypothetical BcDNA:GH11973 - Drosophila melanogaster; uncharacterized protein 791442 4984547 An11g03160 Aspergillus niger uncharacterized protein XP_001394318.1 789984 R 5061 CDS An11g03170 4984548 complement(join(792957..793246,793305..793464,793536..793880,793942..793977)) VII 1 NT_166526.1 Title: similarity to hypothetical phosphoglycerate mutase SPAC5H10.03 - Schizosaccharomyces pombe; uncharacterized protein 793977 4984548 An11g03170 Aspergillus niger uncharacterized protein XP_001394319.1 792957 R 5061 CDS An11g03180 4984549 complement(join(794783..794905,794958..798660,798720..798922)) VII 1 NT_166526.1 Catalytic activity: ATP + ubiquitin + protein lysine = AMP + pyrophosphate + protein N-ubiquityllysine.; Remark: similarity to the human ubiquitin-conjugating enzyme E6AP patent WO9518974-A.; Remark: ubiquitin is coupled to protein by a peptide bond between the C-terminal glycine of ubiquitin and epsilon-amino groups of lysine residues in the protein. An intermediate in the reaction contains one ubiquitin residue bound as a thiolester to the enzyme, and a residue of ubiquitin adenylate non-covalently bound to the enzyme.; Similarity: belongs to the hect-type e3 ubiquitin-protein ligase domain proteins.; Title: similarity to ubiquitin-ligase E6AP from patent WO9518974-A - Homo sapiens; See PMID 7708685; uncharacterized protein 798922 4984549 An11g03180 Aspergillus niger uncharacterized protein XP_001394320.1 794783 R 5061 CDS An11g03190 4984550 complement(join(799808..800514,800568..800599,800812..800882,800932..800934)) VII 1 NT_166526.1 Title: weak similarity to parasporal crystal protein C53 - Bacillus thuringiensis; uncharacterized protein 800934 4984550 An11g03190 Aspergillus niger uncharacterized protein XP_001394321.3 799808 R 5061 CDS An11g03200 4984551 complement(802511..804061) VII 1 NT_166526.1 Function: inulinases catalyse the endohydrolysis of 2,1-beta-D-fructosidic linkages in inulin.; Gene-ID: inuA; Remark: only this ORF with a match to the endoinulinase gene inuA from A. niger could be found; inuB is missing, probably due to strain differences.; Remark: the predicted ORF differs from 1 to 15 amino acids from the published sequences of inulinases from A. niger.; Similarity: the predicted ORF shows strong similarity to EMBL:AB012771 A. niger inuA gene for inulinase and EMBL:AB012772 A. niger inuB gene for inulinase.; Similarity: the predicted ORF shows strong similarity to both isoenzymes with inulinase activity in A. niger, inuA and inuB.; See PMID 9805373; inulinase inuA-Aspergillus niger 804061 inuA 4984551 inuA Aspergillus niger inulinase inuA-Aspergillus niger XP_001394322.1 802511 R 5061 CDS An11g03210 84592244 complement(join(<804999..805182,805247..805393,805467..805548)) VII 1 NT_166526.1 Function: glycosyl hydrolases catalyse the hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides.; Remark: the conserved regions characteristic for glycosyl hydrolases is located in the N-terminal section,which was not alligned with the predicted ORF.; Remark: three putative frameshifts due to possible sequencing errors were corrected: at position 13219 one missing bp, at position 13245 one missing bp and at position 13433 one bp too much.; Similarity: the inner region of the predicted ORF (amino acid 40 to 120) shows similarity to several glycosyl hydrolases from different species, which display various substrat specificities.; Similarity: the predicted ORF overlaps with EMBL:AB012771 A. niger inuA gene for inulinase.; Title: strong similarity to sucrose:sucrose 1-fructosyltransferase AFSS1FRUC_1 - Aspergillus foetidus [putative frameshift]; putative frameshift; See PMID 9495772; uncharacterized protein 805548 84592244 An11g03210 Aspergillus niger uncharacterized protein XP_059606709.1 804999 R 5061 CDS An11g03220 4984553 complement(join(806371..807288,807350..807610,807668..808098,808147..808442,808497..808588,808652..808666,808735..808749,808801..808848)) VII 1 NT_166526.1 Function: GAL4 of S. cerevisiae activates the transcription of several genes involved in galactose metabolism.; Remark: the systematic name for GAL4 of S. cerevisiae is YPL248C.; Similarity: the predicted ORF shows similarity to several 6-cysteine zinc finger-containing transcription factors from different species.; Title: similarity to transcription factor Gal4 -Saccharomyces cerevisiae; nucleus; See PMID 1892477; See PMID 6366516; See PMID 8312971; uncharacterized protein 808848 4984553 An11g03220 Aspergillus niger uncharacterized protein XP_059606710.1 806371 R 5061 CDS An11g03230 4984554 join(809873..810035,810098..810248,810311..811278,811331..811614,811666..811704) VII 1 NT_166526.1 Function: cytochrome P450 enzymes usually act as terminal oxidases of a variety of structurally unrelated combounds (erg5 is a C-22 sterol desaturase, which is involved in ergosterol biosynthesis) in multicomponent electron transfer chains, called P450-containing monooxygenase systems.; Similarity: the predicted ORF shows similarity to several cytochrome P450 isozymes from different species.; Title: strong similarity to cytochrome P450 sterol delta22-desaturase Erg5 - Saccharomyces cerevisiae; See PMID 8635732; See PMID 10770760; uncharacterized protein 811704 4984554 An11g03230 Aspergillus niger uncharacterized protein XP_001394325.1 809873 D 5061 CDS An11g03240 4984555 complement(join(812156..812181,812236..812597,812650..813013,813091..813247)) VII 1 NT_166526.1 Catalytic activity: ard of C. tropicalis converts D-arabinitol + NAD(+) = D-ribulose + NADH.; Function: ard of C. tropicalis is a NAD-dependent short-chain alcohol dehydrogenase which catalyzes the NAD(+)-dependent oxidation at carbon 4 to yield D-ribulose.; Similarity: the predicted ORF overlaps with EMBLEST:BE760294 A. niger.; Similarity: the predicted ORF shows strong similarity to several oxidoreductases/short chain dehydrogenase from several species, which display different specificities.; Title: strong similarity to NAD-dependent D-arabinitol dehydrogenase ard - Candida tropicalis; See PMID 7698655; See PMID 8250887; uncharacterized protein 813247 4984555 An11g03240 Aspergillus niger uncharacterized protein XP_059606711.1 812156 R 5061 CDS An11g03250 84592245 complement(join(813514..813663,813781..814014)) VII 1 NT_166526.1 Remark: the predicted ORF is questionable due to the suboptimal intron-exon structure.; Title: questionable ORF; uncharacterized protein 814014 84592245 An11g03250 Aspergillus niger uncharacterized protein XP_059606712.1 813514 R 5061 CDS An11g03260 4984557 join(814117..814316,814377..814453,814507..814590,814646..814714,814768..815168) VII 1 NT_166526.1 Function: due to the similarity to several oxidoreductases, it is assumed that the A. niger gene encodes for a member of the short-chain dehydrogenase family with yet unknown specificity.; Function: sou1 of C. albicans is a sorbitol utilization protein required for L-sorbose assimilation.; Similarity: the predicted ORF shows similarity to oxidoreductases/short-chain dehydrogenase (SDR) from several species, which display different specificities.; Title: strong similarity to short-chain dehydrogenase sou1 - Candida albicans; See PMID 7742302; uncharacterized protein 815168 4984557 An11g03260 Aspergillus niger uncharacterized protein XP_001394328.1 814117 D 5061 CDS An11g03270 4984558 join(815880..815980,816040..817249,817306..817323) VII 1 NT_166526.1 Function: due to the similarity to DNA-binding proteins, it is assummed that the predicted A. niger gene encodes for a protein involved in transcription.; Similarity: the predicted ORF shows similarity to several zinc finger-containing proteins from different species.; Title: strong similarity to hypothetical zinc-finger protein - Schizosaccharomyces pombe; uncharacterized protein 817323 4984558 An11g03270 Aspergillus niger uncharacterized protein XP_001394329.1 815880 D 5061 CDS An11g03290 4984560 complement(join(819031..820054,820104..820776,820848..821061,821162..821407)) VII 1 NT_166526.1 Similarity: the predicted ORF shows similarity to several probable membrane proteins from different species.; Similarity: the similarity of the predicted ORF to the homologues proteins is locally high in the N-terminal part containing the two domains with unknown fuction, the DUF21 transmembrane domain and the CBS domain, spanning the region from amino acid 50 to 400.; Title: strong similarity to hypothetical membrane protein YOL060c - Saccharomyces cerevisiae; uncharacterized protein 821407 4984560 An11g03290 Aspergillus niger uncharacterized protein XP_001394330.1 819031 R 5061 CDS An11g03300 84592246 complement(join(822042..822117,822248..822304,822726..822822,823039..823180)) VII 1 NT_166526.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF; uncharacterized protein 823180 84592246 An11g03300 Aspergillus niger uncharacterized protein XP_059606713.1 822042 R 5061 CDS An11g03310 4984562 join(823508..823598,823780..>826373) VII 1 NT_166526.1 Function: due to the presence of clusters COG0419 and COG1196, it is assumed that the predicted ORF encodes a protein, which has ATPase activity and might be located in the nucleus.; Similarity: the predicted ORF shows similarity to myosin heavy chain proteins from several species.; Similarity: the similarity to myosin heavy chain is resticted to the C-terminal myosin tail, which includes 28-residue repeats that are characteristic for alpha-helical coiled coils, but does not include the ATP-binding and actin-binding domains.; Title: strong similarity to myosin heavy chain -Oryctolagus cuniculus; uncharacterized protein 826373 4984562 An11g03310 Aspergillus niger uncharacterized protein XP_001394332.3 823508 D 5061 CDS An11g03320 84592247 826866..826955 VII 1 NT_166526.1 Remark: the ORF is questionable due to its short lenght of only 29 amino acids.; Title: questionable ORF; uncharacterized protein 826955 84592247 An11g03320 Aspergillus niger uncharacterized protein XP_059605461.1 826866 D 5061 CDS An11g03330 4984564 join(828140..828202,828266..828692,828740..831381) VII 1 NT_166526.1 Remark: the similarity of the predicted ORF to DNA-directed RNA polymerase from several species is due to the presence of a serine/proline-rich region in the ORF,which does not contain conserved repeats and is therefore not homologues.; Similarity: the similarity of the predicted ORF to the putative protein B23L21. 390 of N. crassa is locally high in the N-terminal part ending around amino acid 400.; Title: strong similarity to hypothetical protein B23L21.390 - Neurospora crassa; uncharacterized protein 831381 4984564 An11g03330 Aspergillus niger uncharacterized protein XP_001394334.1 828140 D 5061 CDS An11g03340 4984565 complement(join(831960..832265,832344..832584,832639..832785,832835..832997,833050..833278,833339..833447,833507..833622,833679..833717,833767..833934)) VII 1 NT_166526.1 Catalytic activity: alpha-amylase of A. niger catalyzes the hydrolysis of internal 1,4-alpha-D-glucosidic bonds in oligosaccharides and polysaccharides.; Function: alpha-amylase of A. niger is a glycosyl hydrolase involved in glycogen and starch degradation.; Induction: alpha-amylase of A. niger binds a calcium ion, which is required for its activity.; Similarity: the predicted ORF is nearly identical with the database entry alpha-amylase of A. niger, but differs at amino acid position 254 of the database protein and the predicted ORF is 21 amino acids longer at the N-terminus (sequencing error?).; Similarity: the predicted ORF shows similarity to several A. niger ESTs in the patent and the EMBL database.; See PMID 2207069; acid alpha-amylase-Aspergillus niger 833934 4984565 An11g03340 Aspergillus niger acid alpha-amylase-Aspergillus niger XP_001394335.1 831960 R 5061 CDS An11g03350 4984566 complement(join(834952..835019,835072..836051,836102..836222,836273..836382,836434..836516,836573..836709,836769..837027)) VII 1 NT_166526.1 Function: multidrug transporter are active in the efflux of a varity of (often cytotoxic) compounds, e. g. fnx1 of S. pombe possibly releases a signaling substance into the environment, which could be required for entry of the cell into the quiescent G0 state.; Similarity: the predicted ORF overlaps the promoter region of the 3' ORF and therefore shows similarity to entry EMBL:A00848 A. niger (acid-stable alpha-amylase promoter and upstream activating sequences) and PATENTDNA:AAN91276 (DNA encoding N-terminus A. niger acid stable alpha-amylase plus signal peptide and promoter and upstream activating sequences).; Similarity: the predicted ORF shows similarity to multidrug transporter from different species and with various specificity.; Title: strong similarity to multidrug resistance protein fnx1p - Schizosaccharomyces pombe; uncharacterized protein 837027 4984566 An11g03350 Aspergillus niger uncharacterized protein XP_059605462.1 834952 R 5061 CDS An11g03360 84592248 join(837387..837456,837532..837564,837646..837746) VII 1 NT_166526.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF; uncharacterized protein 837746 84592248 An11g03360 Aspergillus niger uncharacterized protein XP_059605463.1 837387 D 5061 CDS An11g03370 84592249 complement(join(838273..838374,838464..838510,838851..838987,839043..839138,839228..839265)) VII 1 NT_166526.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF; uncharacterized protein 839265 84592249 An11g03370 Aspergillus niger uncharacterized protein XP_059605464.1 838273 R 5061 CDS An11g03380 4984569 join(839444..839518,839587..840417) VII 1 NT_166526.1 Catalytic activity: lysophospholipases convert 2-lysophosphatidylcholine + H(2)O <=> glycerophosphocholine + a fatty acid anion; Function: lysophospholipases are involved in the degradation of phospholipids.; Similarity: the predicted ORF shows similarity to several putative phospholipases from different species,most of which are lysophospholipases.; Title: similarity to monoglyceride lipase mgll - Mus musculus; See PMID 9341166; See PMID 10627494; uncharacterized protein 840417 4984569 An11g03380 Aspergillus niger uncharacterized protein XP_001394339.1 839444 D 5061 CDS An11g03390 4984570 join(841116..841152,841255..841358,841409..842236) VII 1 NT_166526.1 Similarity: the similarity of the predicted ORF to the conserved hypothetical protein and to other protein matches is restricted to its N-terminal part reaching from amino acid 1 to 220, but the conserved SH3-domain in the C-terminal region of the S. pombe protein is not homologues.; Title: strong similarity to hypothetical protein CAB62422.1 - Schizosaccharomyces pombe; uncharacterized protein 842236 4984570 An11g03390 Aspergillus niger uncharacterized protein XP_001394340.1 841116 D 5061 CDS An11g03400 4984571 844248..845732 VII 1 NT_166526.1 Title: strong similarity to hypothetical protein encoded by An12g06660 - Aspergillus niger; uncharacterized protein 845732 4984571 An11g03400 Aspergillus niger uncharacterized protein XP_001394341.1 844248 D 5061 CDS An11g03420 4984573 join(846252..846389,846503..846793,846838..847965) VII 1 NT_166526.1 Function: Rex1p of S. cerevisiae is required for 5S rRNA and tRNA-Arg3 maturation.; Function: Rnh70p of S. cerevisiae is thought to be involved in DNA replication.; Remark: the systematic gene name of RNH70/REX1 of S. cerevisiae is YGR276c.; Title: similarity to ribonuclease H/3-5 exonuclease Rnh70 - Saccharomyces cerevisiae; nucleus; See PMID 10359084; See PMID 10716935; uncharacterized protein 847965 4984573 An11g03420 Aspergillus niger uncharacterized protein XP_001394342.3 846252 D 5061 CDS An11g03430 4984574 join(849494..849686,849751..849880,849942..850133,850185..850336,850384..850628,850680..850951,851008..851386) VII 1 NT_166526.1 Function: ord1 of A. flavus converts O-methylsterigmatocystin to aflatoxin B1.; Pathway: ord1 of A. flavus catalyzes the last step of the aflatoxin biosynthetic pathway.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Similarity: belongs to the CYP64 family of cytochrome P450-type monooxygenases.; Title: strong similarity to hypothetical O-methylsterigmatocystin oxidoreductase ord1 - Aspergillus flavus; See PMID 9143099; uncharacterized protein 851386 4984574 An11g03430 Aspergillus niger uncharacterized protein XP_001394343.3 849494 D 5061 CDS An11g03450 4984576 join(853251..853382,853477..853704,853767..853820) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein dag11 - Agaricus bisporus; uncharacterized protein 853820 4984576 An11g03450 Aspergillus niger uncharacterized protein XP_001394344.1 853251 D 5061 CDS An11g03460 4984577 complement(join(854246..856000,856051..858678)) VII 1 NT_166526.1 Function: co-expression of het-e and het-c leads to cell death.; Function: het-e1 of P. anserina is responsible for vegetative incompatibility.; Remark: het-e1 of P. anserina shows two sequence motifs, a GTP-binding domain and a repeated region that shares similarity with that of the beta-transducin.; Remark: the reactivity of the HET-E protein depends on two functional elements, a GTP-binding domain and several WD40 repeats.; Similarity: the C-terminus contains 8 WD40-like (beta-transducin) repeats.; Title: strong similarity to vegetative incompatibility factor het-e1 - Podospora anserina; See PMID 9435787; See PMID 10875280; See PMID 10974123; See PMID 7557402; uncharacterized protein 858678 4984577 An11g03460 Aspergillus niger uncharacterized protein XP_001394345.1 854246 R 5061 CDS An11g03470 4984578 complement(join(859331..859970,860017..860470,860524..861166)) VII 1 NT_166526.1 Function: P450rm of R. minuta catalyses the formation of isobutene from isovalerate and the 4-hydroxylation of benzoate.; Pathway: P450rm of R. minuta functions in the degradation of L-phenylalanine on the pathway to beta-ketoadipate.; Similarity: belongs to the CYP53 family of cytochromes P450.; Title: strong similarity to bifunctional cytochrome P450rm - Rhodotorula minuta; endoplasmatic reticulum; See PMID 7764227; See PMID 8882724; See PMID 9349702; uncharacterized protein 861166 4984578 An11g03470 Aspergillus niger uncharacterized protein XP_001394346.1 859331 R 5061 CDS An11g03480 4984579 complement(join(862240..862262,862528..862540,862761..864029)) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein encoded by An01g01140 - Aspergillus niger; uncharacterized protein 864029 4984579 An11g03480 Aspergillus niger uncharacterized protein XP_001394347.3 862240 R 5061 CDS An11g03490 4984580 join(865001..865084,865148..865371,865425..865989) VII 1 NT_166526.1 Function: actVB-orf11 of S. coelicolor is possibly involved in actinorhodin biosynthetis.; Similarity: belongs to the short-chain alcohol dehydrogenases family.; Title: strong similarity to hypothetical oxidoreductase actVB-orf11 - Streptomyces coelicolor; See PMID 10400594; uncharacterized protein 865989 4984580 An11g03490 Aspergillus niger uncharacterized protein XP_001394348.1 865001 D 5061 CDS An11g03500 4984581 join(867265..867602,867655..868158,868219..868427,868478..868632) VII 1 NT_166526.1 Catalytic activity: L-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c.; Complex: CYB2 of S. cerevisiae is a homotetramer.; Induction: CYB2 of S. cerevisiae is induced during respiratory adaptation and by L-lactate.; Localization: CYB2 of S. cerevisiae is located at the mitochondrial intermembrane space.; Similarity: a better match of the protein length is observed with peroxisomal glycolate oxidase (EC 1. 1. 3. 15) of Spinacia oleracea.; Similarity: belongs to the FMN-dependent cytochrome b2 family.; Title: strong similarity to L-lactate dehydrogenase precursor Cyb2 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 3004948; uncharacterized protein 868632 4984581 An11g03500 Aspergillus niger uncharacterized protein XP_059605465.1 867265 D 5061 CDS An11g03510 4984582 complement(join(868685..870239,870287..870422,870469..870511)) VII 1 NT_166526.1 Similarity: contains a Zn(2)-Cys(6), fungal-type binuclear cluster domain.; Similarity: the ORF encoded protein shows also weak similarity to hypothetical transcriptional regulator PRO1 from Sordaria brevicollis.; Title: strong similarity to hypothetical protein encoded by An02g08760 - Aspergillus niger; uncharacterized protein 870511 4984582 An11g03510 Aspergillus niger uncharacterized protein XP_001394350.3 868685 R 5061 CDS An11g03520 4984583 complement(871299..871988) VII 1 NT_166526.1 Similarity: shows abundant unspecific matches to a variety of threonine-, serine- and glycine-rich proteins from diverse species.; Title: weak similarity to hypothetical protein encoded by An02g14500 - Aspergillus niger; uncharacterized protein 871988 4984583 An11g03520 Aspergillus niger uncharacterized protein XP_001394351.1 871299 R 5061 CDS An11g03530 4984584 complement(join(872347..872695,872746..873189,873237..873409,873460..873484,873533..873823,873878..874083)) VII 1 NT_166526.1 Function: ttuB of A. vitis facilitates the cellular uptake of tartrate.; Similarity: belongs to the major facilitator superfamily (MFS).; Title: strong similarity to tartrate transport protein ttuB - Agrobacterium vitis; plasma membrane; See PMID 7592429; uncharacterized protein 874083 4984584 An11g03530 Aspergillus niger uncharacterized protein XP_001394352.1 872347 R 5061 CDS An11g03540 4984585 complement(join(874558..874899,874948..876078)) VII 1 NT_166526.1 Function: TRI11 of F. sporotrichioides converts isotrichodermin to 15-decalonectrin.; Pathway: TRI11 of F. sporotrichioides is involved in the biosynthesis of fungal toxins of the trichothecene family.; Pathway: the product of the reaction catalyzed by TRI11 of F. sporotrichioides, 15-decalonectrin, is the starting point for various branches of trichothecene biosynthesis pathways leading to different trichothecene species.; Similarity: belongs to the superfamily of cytochrome P450 monooxygenases.; Title: strong similarity to cytochrome P450 monooxygenase TRI11 - Fusarium sporotrichioides; See PMID 9435078; uncharacterized protein 876078 4984585 An11g03540 Aspergillus niger uncharacterized protein XP_001394353.1 874558 R 5061 CDS An11g03550 84592250 complement(join(877691..877831,877927..877992,878049..878351,878415..878684,878768..879094)) VII 1 NT_166526.1 hypothetical protein 879094 84592250 An11g03550 Aspergillus niger hypothetical protein XP_059605466.1 877691 R 5061 CDS An11g03560 84592251 complement(join(880657..880735,880785..880876,880962..881273,881392..881460)) VII 1 NT_166526.1 hypothetical protein 881460 84592251 An11g03560 Aspergillus niger hypothetical protein XP_059605467.1 880657 R 5061 CDS An11g03570 4984588 join(881607..881898,881994..882306,882406..882637,882710..883000,883057..883176,883230..883393,883448..883610) VII 1 NT_166526.1 Function: TRI4 of F. sporotrichioides is a cytochrome P450-type monooxygenase of the CYP58 subfamily.; Pathway: TRI4 of F. sporotrichioides catalyzes the initial oxygenation step of trichothecene biosynthesis and participates in apotrichodiol biosynthesis.; Remark: trichothecenes are sesquiterpenoid mycotoxins and act as protein synthesis inhibitors for eukaryotic organisms.; Title: strong similarity to cytochrome P450 monooxygenase TRI4 - Fusarium sporotrichioides; See PMID 7651333; uncharacterized protein 883610 4984588 An11g03570 Aspergillus niger uncharacterized protein XP_059605468.1 881607 D 5061 CDS An11g03580 4984589 complement(join(884122..884448,884511..884995,885048..885927)) VII 1 NT_166526.1 Catalytic activity: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.; Function: laccase of N. crassa is a multicopper oxidase containing type 1, type 2, and type 3 copper centers.; Pathway: laccase of N. crassa is probably involved in the degradation/detoxification of lignin and/or it's derivatives.; Title: strong similarity to precursor of laccase -Neurospora crassa; See PMID 2961749; uncharacterized protein 885927 4984589 An11g03580 Aspergillus niger uncharacterized protein XP_001394357.1 884122 R 5061 CDS An11g03590 4984590 887172..888917 VII 1 NT_166526.1 Catalytic activity: digallate + H2O = 2 gallate.; Complex: tannase of A. oryzae forms a heterooctamer consisting of four pairs of the two different subunits.; Remark: the tannase precursor of A. oryzae is post-translationally cleaved in two subunits which are linked by a disulfide bond.; Title: strong similarity to precursor of tannase -Aspergillus oryzae; See PMID 8917102; uncharacterized protein 888917 4984590 An11g03590 Aspergillus niger uncharacterized protein XP_001394358.1 887172 D 5061 CDS An11g03600 4984591 join(889353..889478,889550..889643,889883..890095,890167..890786) VII 1 NT_166526.1 Function: CIH1 of C. lindemuthianum is involved in the establishment and maintenance of biotrophy.; Localization: the CIH1 glycoprotein is specifically located at the biotrophic interface formed in the C. lindemuthianum-bean interaction.; Title: similarity to intracellular hyphae protein 1 CIH1 - Colletotrichum lindemuthianum; cell wall; See PMID 9721685; uncharacterized protein 890786 4984591 An11g03600 Aspergillus niger uncharacterized protein XP_001394359.3 889353 D 5061 CDS An11g03610 4984592 join(893586..894555,894609..898018) VII 1 NT_166526.1 Function: ankyrins act as protein linker between the integral membrane proteins and spectrin-based cytoskeleton.; Remark: ankyrin repeats are often contained in other proteins (which are not classified with the ankyrin family) and ensure protein-protein interactions as well as interactions between proteins and nucleic acids.; Similarity: the predicted A. niger protein shows strong similarity to domains of ankyrin.; Title: similarity to ankyrin Ank2 - Drosophila melanogaster; See PMID 10810176; See PMID 10844021; uncharacterized protein 898018 4984592 An11g03610 Aspergillus niger uncharacterized protein XP_059605469.1 893586 D 5061 CDS An11g03620 4984593 join(899180..899335,899392..899601,899674..900279) VII 1 NT_166526.1 Function: tfdA of B. sp. is involved in chlorocatechol degradation.; Title: strong similarity to 2,4-dichlorophenoxyacetic acid/alpha-ketoglutarate dioxygenase tfdA - Burkholderia sp.; See PMID 8779585; uncharacterized protein 900279 4984593 An11g03620 Aspergillus niger uncharacterized protein XP_001394361.1 899180 D 5061 CDS An11g03630 4984594 join(900603..900676,900745..901529,901564..901794,901855..902464,902522..903089) VII 1 NT_166526.1 Title: similarity to hypothetical transcription factor Aro80 - Saccharomyces cerevisiae; uncharacterized protein 903089 4984594 An11g03630 Aspergillus niger uncharacterized protein XP_059605470.1 900603 D 5061 CDS An11g03640 4984595 join(904348..904986,905036..906308,906359..906846) VII 1 NT_166526.1 Function: OPT1 of C. albicans mediates the cellular uptake of oligopeptides.; Function: OPT1 of C. albicans specifically transports tetra- and pentapeptides.; Title: strong similarity to transmemrane oligopeptide transporter OPT1 - Candida albicans; See PMID 9043116; uncharacterized protein 906846 4984595 An11g03640 Aspergillus niger uncharacterized protein XP_001394363.1 904348 D 5061 CDS An11g03660 4984597 complement(join(907480..907834,908134..908151,908200..908224,908250..908440,908721..908841,908890..909013,909065..909099,909188..909224,909284..909337,909445..909516)) VII 1 NT_166526.1 Similarity: mTMT of M. musculus belongs to the tryptase family of serine proteases but is distinguished by a hydrophobic, possibly membrane spanning, C-terminal extension.; Similarity: the N-terminus shows similarity to the N-terminal portion of the phospholipase A2 activating protein PLA2P of Homo sapiens.; Title: weak similarity to hypothetical transmembrane tryptase mTMT - Mus musculus; See PMID 10521469; uncharacterized protein 909516 4984597 An11g03660 Aspergillus niger uncharacterized protein XP_059605471.1 907480 R 5061 CDS An11g03670 84592252 join(910240..910319,910430..911051,911107..911508) VII 1 NT_166526.1 Title: similarity to hypothetical reductase encoded by 2SCG18.20c - Streptomyces coelicolor; uncharacterized protein 911508 84592252 An11g03670 Aspergillus niger uncharacterized protein XP_059605472.1 910240 D 5061 CDS An11g03680 4984599 complement(join(912244..912351,912431..912680,912754..913183,913277..913559)) VII 1 NT_166526.1 Catalytic activity: Cinnamyl alcohol + NADP(+) = cinnamaldehyde + NADPH.; Function: CAD of E. gunnii reduces hydroxycinnamyl aldehydes (sinapyl, paracoumaryl, coniferyl aldehydes) to the corresponding alcohols.; Pathway: CAD of E. gunnii catalyzes the final step in the production of monomeric lignin precursors.; Title: strong similarity to cinnamyl alcohol dehydrogenase CAD - Eucalyptus gunnii; See PMID 8490129; uncharacterized protein 913559 4984599 An11g03680 Aspergillus niger uncharacterized protein XP_001394366.3 912244 R 5061 CDS An11g03690 4984600 join(913929..914144,914211..914278,914364..915327,915386..916375) VII 1 NT_166526.1 Function: UaY of A. nidulans binds to the sequence 5'-TCGG-6X-CCGA.; Function: UaY of A. nidulans mediates the induction of a number of unlinked genes involved in purine utilization.; Title: strong similarity to positive regulator of purine utilisation uaY - Aspergillus nidulans; nucleus; See PMID 7729421; uncharacterized protein 916375 4984600 An11g03690 Aspergillus niger uncharacterized protein XP_059605473.1 913929 D 5061 CDS An11g03700 4984601 complement(join(916818..916976,917030..918364,918421..918459)) VII 1 NT_166526.1 Function: HXT1p of U. fabae facilitates the uptake of D-glucose and D-fructose in the haustorial complex.; Localization: HXT1p of U. fabae is exclusivly located to the plasma membrane of the haustorial complex.; Title: strong similarity to hexose transporter HXT1 - Uromyces fabae; plasma membrane; See PMID 11390980; uncharacterized protein 918459 4984601 An11g03700 Aspergillus niger uncharacterized protein XP_059605474.1 916818 R 5061 CDS An11g03710 84592253 join(918692..918723,918808..918968,919207..919264,919349..919408,919483..919621) VII 1 NT_166526.1 hypothetical protein 919621 84592253 An11g03710 Aspergillus niger hypothetical protein XP_059605475.1 918692 D 5061 CDS An11g03720 84592254 complement(join(920088..920200,920267..920351,920392..920428,920511..920599)) VII 1 NT_166526.1 hypothetical protein 920599 84592254 An11g03720 Aspergillus niger hypothetical protein XP_059605476.1 920088 R 5061 CDS An11g03730 4984604 complement(join(921296..921752,921804..921921,921986..922358,922431..922586)) VII 1 NT_166526.1 Title: weak similarity to integral membrane protein PTH11 from patent WO9913094-A2 - Magnaporthe grisea; uncharacterized protein 922586 4984604 An11g03730 Aspergillus niger uncharacterized protein XP_001394371.1 921296 R 5061 CDS An11g03740 4984605 join(924199..924446,924507..924707,924769..926032) VII 1 NT_166526.1 Function: isoamyl alcohol oxidase may play a role in the Ehrlich pathway of branched-chain amino acid utilization.; Title: strong similarity to isoamyl alcohol oxidase mreA - Aspergillus oryzae; uncharacterized protein 926032 4984605 An11g03740 Aspergillus niger uncharacterized protein XP_001394372.1 924199 D 5061 CDS An11g03750 84592255 join(927464..927477,927618..927784,927892..927966,928127..928415,928509..928818,928912..929007) VII 1 NT_166526.1 hypothetical protein 929007 84592255 An11g03750 Aspergillus niger hypothetical protein XP_059605477.1 927464 D 5061 CDS An11g03760 4984607 join(929119..929922,929976..930662) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein BAC67939.1 - Streptomyces avermitilis; uncharacterized protein 930662 4984607 An11g03760 Aspergillus niger uncharacterized protein XP_001394374.1 929119 D 5061 CDS An11g03770 4984608 join(931208..931636,931777..931833,931939..931964,932069..932189) VII 1 NT_166526.1 Title: strong similarity to hypothetical blastomyces yeast phase-specific protein 1 related protein CAD70756.1 - Neurospora crassa; uncharacterized protein 932189 4984608 An11g03770 Aspergillus niger uncharacterized protein XP_059605478.1 931208 D 5061 CDS An11g03780 4984609 join(932665..933265,933375..934252,934300..934372,934422..934852) VII 1 NT_166526.1 Similarity: contains a fungal-type Zn(2)-Cys(6) binuclear cluster DNA-binding domain.; Title: strong similarity to hypothetical transcription regulator SPBC530.05 - Schizosaccharomyces pombe; uncharacterized protein 934852 4984609 An11g03780 Aspergillus niger uncharacterized protein XP_059605479.1 932665 D 5061 CDS An11g03790 4984610 complement(join(934971..935155,935230..935595,935667..935716,935777..935797,935875..936090,936170..936387)) VII 1 NT_166526.1 Title: similarity to hypothetical protein SC1C3.21 -Streptomyces coelicolor; uncharacterized protein 936387 4984610 An11g03790 Aspergillus niger uncharacterized protein XP_001394377.1 934971 R 5061 CDS An11g03800 4984611 join(936767..936817,936868..938052) VII 1 NT_166526.1 Catalytic activity: salicylate + NADH + H(+) + O2 = catechol + NAD(+) + H2O + CO2.; Function: sal of P. putida catalyzes the decarboxylative hydroxylation of salicylate.; Pathway: sal of P. putida is involved in the lower napthalene catabolic pathway which involves conversion of salicylate to lower amphibolic intermediates.; Title: strong similarity to FAD-dependent salicylate hydroxylase sal - Pseudomonas putida; See PMID 8695632; uncharacterized protein 938052 4984611 An11g03800 Aspergillus niger uncharacterized protein XP_001394378.1 936767 D 5061 CDS An11g03810 4984612 join(938448..938473,938524..938896) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein mlr0979 - Mesorhizobium loti; uncharacterized protein 938896 4984612 An11g03810 Aspergillus niger uncharacterized protein XP_001394379.1 938448 D 5061 CDS An11g03820 4984613 join(939488..939531,939849..940557) VII 1 NT_166526.1 Title: strong similarity to hypothetical flavoprotein oxygenase PA1644 - Pseudomonas aeruginosa; uncharacterized protein 940557 4984613 An11g03820 Aspergillus niger uncharacterized protein XP_059605480.1 939488 D 5061 CDS An11g03830 4984614 join(940958..941115,941184..941239,941318..941481,941554..941595) VII 1 NT_166526.1 Title: similarity to hypothetical protein yciI -Escherichia coli; uncharacterized protein 941595 4984614 An11g03830 Aspergillus niger uncharacterized protein XP_001394381.1 940958 D 5061 CDS An11g03860 4984617 complement(join(942955..943056,943110..943270,943321..943382,943434..944050,944106..944265,944314..944708,944763..944976,945105..945229)) VII 1 NT_166526.1 Function: ftsH2 of C. merolae is involved in mitochondrial division.; Function: the ATPases of the FtsH family are involved in the degradation of soluble and membrane proteins during organelle division or prokaryotic cell division.; Similarity: belongs to the family of ATPases associated with various cellular activities (AAA).; Title: similarity to mitochondrial ATP-dependent protease ftsH2 - Cyanidioschyzon merolae; See PMID 10598100; uncharacterized protein 945229 4984617 An11g03860 Aspergillus niger uncharacterized protein XP_059605481.1 942955 R 5061 CDS An11g03870 4984618 join(945943..947690,947750..948303,948362..948722,948788..950733,950851..950939,951088..951110,951198..951224,951328..951333,951420..951507,951560..951627,951918..952185) VII 1 NT_166526.1 Function: co-expression of het-e and het-c lead to cell death.; Function: het-e1 of P. anserina is responsible for vegetative incompatibility.; Remark: het-e1 of P. anserina shows also two sequence motifs, a GTP-binding domain and a repeated region that shares similarity with that of the beta-transducin.; Remark: the reactivity of the HET-E protein depends on two functional elements, a GTP-binding domain and several WD40 repeats.; Title: similarity to vegetative heterokaryon incompatibility factor het-e1 - Podospora anserina; See PMID 9435787; See PMID 10875280; See PMID 10974123; See PMID 7557402; uncharacterized protein 952185 4984618 An11g03870 Aspergillus niger uncharacterized protein XP_059605482.1 945943 D 5061 CDS An11g03880 4984619 952597..953529 VII 1 NT_166526.1 Catalytic activity: L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O.; Pathway: DDPS of B. methanolicus catalyzes the first step in diaminopimelate and lysine biosynthesis.; Similarity: homologous to protein of patent database entry PATENTPROT:AAB47100.; Title: strong similarity to dihydrodipicolinate synthase DDPS from patent EP1074626-A2 - Bacillus methanolicus; uncharacterized protein 953529 4984619 An11g03880 Aspergillus niger uncharacterized protein XP_001394384.1 952597 D 5061 CDS An11g03890 4984620 join(953905..955208,955262..956174) VII 1 NT_166526.1 Similarity: B912. 10 of N. crassa is longer than the ORF (1004 compared to 738 amino acids). More than 100 C-terminal amino acids of the ORF are not included in the alignment between the two proteins.; Similarity: contains a fungal-type Zn(2)-Cys(6) binuclear cluster DNA-binding domain typical for fungal transcriptional regulators.; Title: strong similarity to hypothetical conserved protein B9I2.10 - Neurospora crassa; uncharacterized protein 956174 4984620 An11g03890 Aspergillus niger uncharacterized protein XP_059605483.1 953905 D 5061 CDS An11g03900 4984621 join(956451..956573,956631..956636,956700..956763,956812..956910,956961..957114,957168..957345,957402..958274) VII 1 NT_166526.1 Function: TNA1 of S. cerevisiae is necessary for cellular uptake of nicotinic acid at low concetrations.; Remark: the systematic gene name of TNA1 of S. cerevisiae is YGR260w.; Similarity: belongs to the major facilitator superfamily (MFS).; Similarity: shows strong homology to several hypothetical allantoate transporters.; Title: strong similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563; uncharacterized protein 958274 4984621 An11g03900 Aspergillus niger uncharacterized protein XP_059605484.1 956451 D 5061 CDS An11g03920 4984623 complement(join(959482..959522,959622..965752,965819..965978,966057..966762,966823..966979,967047..967480,967599..967867,967941..968289)) VII 1 NT_166526.1 Function: lovF of A. terreus is a multifunctional enzyme required for the formation of 2-methylbutyrate which is subsequently assembled with monacolin J to form lovastatin.; Pathway: lovF of A. terreus is involved in lovastatin biosynthesis.; Title: strong similarity to lovastatin diketide synthase lovF - Aspergillus terreus; See PMID 10334994; uncharacterized protein 968289 4984623 An11g03920 Aspergillus niger uncharacterized protein XP_001394387.1 959482 R 5061 CDS An11g03930 4984624 complement(join(968393..968451,968529..968573,968627..968688,968776..968836,968930..969439,969508..969585,969668..969695)) VII 1 NT_166526.1 Similarity: shares a conserved motif (GPFDGILaFShGA,the lowercase letters represent residues deviating from the consensus) with a number of hypothetical proteins and the dihydrofolate reductase DFR1 of S. pombe.; Similarity: the ORF encoded protein shows also weak similarity to hypothetical dihydrofolate reductase SPAC22A12. 06c from Schizosaccharomyces pombe.; Title: similarity to hypothetical protein encoded by An15g02140 - Aspergillus niger; uncharacterized protein 969695 4984624 An11g03930 Aspergillus niger uncharacterized protein XP_001394388.3 968393 R 5061 CDS An11g03940 4984625 join(970129..970206,970287..971163,971260..971909) VII 1 NT_166526.1 Function: P450rm of R. minuta catalyses the formation of isobutene from isovalerate and the 4-hydroxylation of benzoate.; Pathway: P450rm of R. minuta functions in the degradation of L-phenylalanine on the pathway to beta-ketoadipate.; Similarity: belongs to the CYP53 family of cytochromes P450.; Title: strong similarity to bifunctional cytochrome P450rm - Rhodotorula minuta; endoplasmatic reticulum; See PMID 7764227; See PMID 8882724; See PMID 9349702; uncharacterized protein 971909 4984625 An11g03940 Aspergillus niger uncharacterized protein XP_001394389.1 970129 D 5061 CDS An11g03950 4984626 complement(join(972937..973006,973096..973108,973204..974084,974181..974289,974346..974478,974553..974747)) VII 1 NT_166526.1 Function: AKT2 of Alternaria alternata encodes a protein of unknown function involved in the biosynthesis of the host-specific AK-toxin.; Similarity: belongs to the superfamily of alpha/beta hydrolases.; Title: similarity to hypothetical protein required for biosynthesis of the host-specific AK-toxin Akt2 -Alternaria alternata; See PMID 10432635; uncharacterized protein 974747 4984626 An11g03950 Aspergillus niger uncharacterized protein XP_001394390.3 972937 R 5061 CDS An11g03960 4984627 join(975475..975682,975769..976222,976287..976638) VII 1 NT_166526.1 Function: PTH11 of M. grisea is involved in pathogenicity signaling.; Function: PTH11 of M. grisea mediates appressorium differentiation in response to inductive substrate cues.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529; uncharacterized protein 976638 4984627 An11g03960 Aspergillus niger uncharacterized protein XP_001394391.1 975475 D 5061 CDS An11g03970 4984628 complement(join(978919..979224,979281..980746,980807..980825)) VII 1 NT_166526.1 Similarity: belongs to the AAA family of ATPases.; Title: similarity to hypothetical AAA family ATPase SCD8A.32c - Streptomyces coelicolor; uncharacterized protein 980825 4984628 An11g03970 Aspergillus niger uncharacterized protein XP_001394392.1 978919 R 5061 CDS An11g03980 84592256 join(981569..981653,981724..981836,981968..982014,982122..982329) VII 1 NT_166526.1 Similarity: related to coproporphyrinogen oxidase N-terminus.; Similarity: the ORF encoded protein shows similarities to the matching protein of A. niger only at the very N-terminus.; Title: weak similarity to hypothetical protein encoded by An12g05650 - Aspergillus niger; uncharacterized protein 982329 84592256 An11g03980 Aspergillus niger uncharacterized protein XP_059605485.1 981569 D 5061 CDS An11g03990 84592257 join(982580..982593,982675..982760,982921..983073,983129..983427) VII 1 NT_166526.1 Title: weak similarity to hypothetical protein encoded by An18g02800 - Aspergillus niger; uncharacterized protein 983427 84592257 An11g03990 Aspergillus niger uncharacterized protein XP_059605486.1 982580 D 5061 CDS An11g04000 4984631 983885..985426 VII 1 NT_166526.1 Function: WHIP of M. musculus is involved in aging control.; Localization: WHIP co-localizes with the Werner's syndrome helicase/exonuclease in granular structures in the nucleus.; Similarity: WHIP of M. musculus is highly conserved from E. coli to human.; Similarity: related to DEAH-box subfamily of ATP-dependent helicases and other ATPases.; Title: strong similarity to Werner helicase interacting protein WHIP - Mus musculus; nucleus; See PMID 11301316; uncharacterized protein 985426 4984631 An11g04000 Aspergillus niger uncharacterized protein XP_001394395.1 983885 D 5061 CDS An11g04010 4984632 complement(986347..987738) VII 1 NT_166526.1 Function: Ppr1p of S. cerevisiae transcriptionally activates the structural genes URA1 and URA3.; Pathway: Ppr1p of S. cerevisiae regulates genes involved in the pyrimidine biosynthesis.; Title: similarity to transcription activator Ppr1 -Saccharomyces cerevisiae; See PMID 8668194; See PMID 6096561; uncharacterized protein 987738 4984632 An11g04010 Aspergillus niger uncharacterized protein XP_059605487.1 986347 R 5061 CDS An11g04020 4984633 988966..989982 VII 1 NT_166526.1 Similarity: belongs to the carboxylesterases type-B family.; Similarity: shows homology to the protein patent database entry PATENTPROT:AAY01820.; Title: similarity to esterase from patent JP11075860-A - Acetobacter pasteurianus; uncharacterized protein 989982 4984633 An11g04020 Aspergillus niger uncharacterized protein XP_001394397.1 988966 D 5061 CDS An11g04030 4984634 complement(join(990434..990834,990898..991066,991132..991198,991275..991759)) VII 1 NT_166526.1 Catalytic activity: pnlA of G. cingulata catalyzes the eliminative cleavage of pectin to give oligosaccharides with terminal 4-deoxy-6-methyl-alpha-D-galact-4-enuronosyl groups.; Function: pnlA of G. cingulata is involved in pectin utilization.; Remark: Glomerella cingulata is used synonymous for Colletotrichum gloeosporioides.; Similarity: belongs to the polysaccharide lyase family 1.; Title: strong similarity to pectin lyase pnlA -Glomerella cingulata; extracellular/secretion proteins; See PMID 8181749; uncharacterized protein 991759 4984634 An11g04030 Aspergillus niger uncharacterized protein XP_001394398.1 990434 R 5061 CDS An11g04040 4984635 complement(join(993119..993235,993297..993398,993468..993814,993875..993947,994025..994239,994308..994758)) VII 1 NT_166526.1 Catalytic activity: PGX1 of C. carbonum catalyzes the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans.; Function: PGX1 of C. carbonum is involved in the degradation of pectin.; Similarity: belongs to family 28 of glycosyl hydrolases.; Title: strong similarity to exo-alpha 1,4-polygalacturonase PGX1 - Cochliobolus carbonum; extracellular/secretion proteins; See PMID 9546185; uncharacterized protein 994758 4984635 An11g04040 Aspergillus niger uncharacterized protein XP_001394399.1 993119 R 5061 CDS An11g04050 4984636 complement(join(996266..996333,996387..996703,996773..997096,997158..997772,997831..998006)) VII 1 NT_166526.1 Similarity: contains a fungal-type Zn(2)-Cys(6) binuclear DNA-binding domain.; Title: similarity to hypothetical transcription regulator SPBP8B7.30c - Schizosaccharomyces pombe; uncharacterized protein 998006 4984636 An11g04050 Aspergillus niger uncharacterized protein XP_059605488.1 996266 R 5061 CDS An11g04060 4984637 join(998281..998313,998365..999231) VII 1 NT_166526.1 Catalytic activity: IFR of M. sativa catalyzes the NADPH-dependent reduction of 2'-hydroxyformononetin stereospecifically to (3R)-vestitone.; Function: IFR of M. sativa introduces one of two chiral centers during the biosynthesis of the phytoalexin medicarpin.; Pathway: IFR of M. sativa participates in the biosynthesis of medicarpin, an antimicrobial phytoalexin,which is a product of the isoflavonoid branch of the phenylpropanoid pathway.; Title: similarity to isoflavone reductase IFR -Medicago sativa; See PMID 7866024; See PMID 1912490; uncharacterized protein 999231 4984637 An11g04060 Aspergillus niger uncharacterized protein XP_001394401.1 998281 D 5061 CDS An11g04070 84592258 complement(join(999728..999776,999863..1000000,1000087..1000244,1000300..1000346,1000421..1000455,1000552..1000619)) VII 1 NT_166526.1 Similarity: shares homology with a conserved N-terminal domain of various protein kinases from diverse species.; Title: weak similarity to polo-like kinase kinase xPlkk1 - Xenopus laevis; uncharacterized protein 1000619 84592258 An11g04070 Aspergillus niger uncharacterized protein XP_059605489.1 999728 R 5061 CDS An11g04080 84592259 1000667..1001296 VII 1 NT_166526.1 hypothetical protein 1001296 84592259 An11g04080 Aspergillus niger hypothetical protein XP_059605490.1 1000667 D 5061 CDS An11g04090 4984640 complement(1001679..1003592) VII 1 NT_166526.1 Function: AGA1 of S. cerevisiae is involved in cell surface attachment of a-agglutinin.; Similarity: also related to nitrate reductase beta chain of Streptomyces coelicolor.; Title: weak similarity to agglutinin attachment protein Aga1 - Saccharomyces cerevisiae; See PMID 2072914; uncharacterized protein 1003592 4984640 An11g04090 Aspergillus niger uncharacterized protein XP_001394404.1 1001679 R 5061 CDS An11g04100 4984641 join(1004665..1004707,1004760..1005358) VII 1 NT_166526.1 Function: cdh of T. versicolor is involved in the degradation of lignocellulose.; Induction: cdh of T. versicolor is activated under cellulolytic conditions.; Similarity: the homology to cdh of T. versicolor is limited to it's N-terminal region.; Title: weak similarity to cellobiose dehydrogenase cdh - Trametes versicolor; See PMID 9573367; uncharacterized protein 1005358 4984641 An11g04100 Aspergillus niger uncharacterized protein XP_001394405.1 1004665 D 5061 CDS An11g04110 4984642 1006201..1007913 VII 1 NT_166526.1 Similarity: contains two tetratricopeptide repeat (TPR) domains probably involved in protein-protein interactions.; Title: strong similarity to hypothetical protein SCF91.02c - Streptomyces coelicolor; uncharacterized protein 1007913 4984642 An11g04110 Aspergillus niger uncharacterized protein XP_001394406.1 1006201 D 5061 CDS An11g04120 4984643 join(1008263..1008382,1008433..1008954,1008993..1009061) VII 1 NT_166526.1 Similarity: shows weak homology to a variety of protein kinases of diverse species.; Similarity: the ORF encoded protein shows also weak similarity to hypothetical protein kinase F39F10. 3 from Caenorhabditis elegans.; Title: strong similarity to hypothetical protein encoded by An06g00610 - Aspergillus niger; uncharacterized protein 1009061 4984643 An11g04120 Aspergillus niger uncharacterized protein XP_059605491.1 1008263 D 5061 CDS An11g04130 84592260 complement(join(1009329..1009742,1009774..1010556)) VII 1 NT_166526.1 Similarity: shows a weak homology match to the protein patent database entry PATENTPROT:AAY19886.; Title: weak similarity to antigenic protein f688.aa from patent WO9859071-A1 - Borrelia burgdorferi; uncharacterized protein 1010556 84592260 An11g04130 Aspergillus niger uncharacterized protein XP_059605492.1 1009329 R 5061 CDS An11g04140 84592261 join(1012395..1012531,1012615..1012699) VII 1 NT_166526.1 hypothetical protein 1012699 84592261 An11g04140 Aspergillus niger hypothetical protein XP_059601573.1 1012395 D 5061 CDS An11g04150 4984646 join(1013574..1013739,1013800..1014167,1014220..1014298,1014345..1014826) VII 1 NT_166526.1 Catalytic activity: alcohol dehydrogenases catalyze the reversible oxidation of primary and secondary alcohols to aldehydes and ketones by NAD+: alcohol + NAD(+) <=> aldehyde or ketone + NaDH.; Remark: alternative names for adh2 are adr2 or YMR303C or YM9952. 05C.; Remark: in yeast are three isozymes of alcolhol dehydrogenase known, the adr2 preferentially catalyses the conversion of ethanol to acetaldehyde and is the glucose-repressed adh of yeast.; Similarity: the predicted ORF overlaps with the A. niger EST BE758920.; Title: strong similarity to alcohol dehydrogenase 2 Adh2 - Saccharomyces cerevisiae; cytoplasm; See PMID 3297923; See PMID 6279086; uncharacterized protein 1014826 4984646 An11g04150 Aspergillus niger uncharacterized protein XP_001394410.1 1013574 D 5061 CDS An11g04160 4984647 complement(join(1015246..1015269,1015300..1015753,1015805..1016535)) VII 1 NT_166526.1 Function: mal23 of S. cerevisiae regulates the coordinate transcription of structural mal6S (maltase) and mal6T (maltose permease) genes.; Similarity: the predicted ORF shows similarity to the transcriptional activator of amylase genes amyR of A. niger.; Title: strong similarity to transcription activator Mal23 - Saccharomyces cerevisiae; nucleus; See PMID 9258674; uncharacterized protein 1016535 4984647 An11g04160 Aspergillus niger uncharacterized protein XP_059601574.1 1015246 R 5061 CDS An11g04168 4984648 join(1017075..1017110,1017250..1017783) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein AAD42396.1 - Zymomonas mobilis; uncharacterized protein 1017783 4984648 An11g04168 Aspergillus niger uncharacterized protein XP_001394412.1 1017075 D 5061 CDS An11g04180 4984649 complement(join(1018071..1018636,1018691..1019796,1019852..1020047,1020110..1020260)) VII 1 NT_166526.1 Function: the chaperone bip is involved in quality control of protein folding.; Gene-ID: bipA; Mapping: bipA from A. niger is mapped to chromosome VII (LG VII); see EMBL Y08868.; endoplasmatic reticulum; See PMID 9370263; See PMID 9830095; See PMID 10653750; dnaK-type molecular chaperone bipA-Aspergillus niger 1020260 bipA 4984649 bipA Aspergillus niger dnaK-type molecular chaperone bipA-Aspergillus niger XP_001394413.1 1018071 R 5061 CDS An11g04190 84592262 join(1020271..1020356,1020498..1020625,1020685..1020741,1020835..1020924,1021209..1021315) VII 1 NT_166526.1 Remark: the predicted ORF is annotated as questionable ORF due to the presence of unusually long intron segments.; Title: questionable ORF; uncharacterized protein 1021315 84592262 An11g04190 Aspergillus niger uncharacterized protein XP_059601575.1 1020271 D 5061 CDS An11g04200 4984651 complement(join(1021608..1022815,1022866..1023048,1023097..1023834,1024019..1024093,1024193..1024418)) VII 1 NT_166526.1 Similarity: the similarity of the predicted ORF to eEF1 alpha chain of C. albicabs is restricted to its C-termial end, starting at amino acid 402 of the predicted protein.; Title: strong similarity to translation elongation factor eEF1 alpha chain - Candida albicans; cytoplasm; uncharacterized protein 1024418 4984651 An11g04200 Aspergillus niger uncharacterized protein XP_001394415.1 1021608 R 5061 CDS An11g04210 4984652 complement(join(1025006..1025933,1025989..1027104,1027159..1028453,1028536..1028649)) VII 1 NT_166526.1 Function: polyA ribonuclease subunit pan2 of S. cerevisiae is required for Pab1p-stimulated poly(A) ribonuclease activity.; Remark: alternate names for pan2 of S. cerevisiae are G3165 or YGL094c.; Similarity: the predicted ORF is identical with A. niger EST BE758876.; Title: strong similarity to polyA ribonuclease subunit Pan2 - Saccharomyces cerevisiae; cytoplasm; See PMID 8550599; See PMID 10669874; uncharacterized protein 1028649 4984652 An11g04210 Aspergillus niger uncharacterized protein XP_059601576.1 1025006 R 5061 CDS An11g04220 4984653 complement(join(1029728..1030185,1030247..1030389,1030444..1031529,1031621..1031772)) VII 1 NT_166526.1 Catalytic activity: cytochrome P450 ALK2-A of C. maltosa catalyses the hydroxylation of n-alkanes at the terminal position.; Induction: the alkane-inducible cytochrome P450 protein family is inducible by alkanes.; Remark: the predicted ORF includes a motiv, that is specific for the cytochrome P450 protein family.; Title: strong similarity to cytochrome P450 alk2A -Candida maltosa; uncharacterized protein 1031772 4984653 An11g04220 Aspergillus niger uncharacterized protein XP_001394417.3 1029728 R 5061 CDS An11g04230 84592263 join(1032524..1032638,1032671..1033115,1033178..1035494) VII 1 NT_166526.1 Similarity: due to the presence of a kinesin light chain motiv the predicted ORF shows similarity to kinesin light chain of several spezies.; Similarity: the similarity to kinesin light chain is restricted to the region with imperfect tandem repeats (TPR), which are believed to mediate protein-protein interactions.; Title: similarity to hypothetical protein BAB75479.1 - Nostoc sp.; uncharacterized protein 1035494 84592263 An11g04230 Aspergillus niger uncharacterized protein XP_059601577.1 1032524 D 5061 CDS An11g04240 4984655 join(1036636..1036784,1036834..1037115,1037164..1037706,1038207..1038251,1038328..1038337,1038685..1038789) VII 1 NT_166526.1 Title: questionable ORF; uncharacterized protein 1038789 4984655 An11g04240 Aspergillus niger uncharacterized protein XP_001394419.3 1036636 D 5061 CDS An11g04250 4984656 complement(join(1039385..1039819,1039879..1041911,1041960..1042267,1042430..1042437,1042504..1042710)) VII 1 NT_166526.1 Catalytic activity: l-2-aminoadipate 6-semialdehyde + NADP(+) + H(2)O = l-2-aminoadipate + NADPH.; Complex: the aminoadipate reductase enzyme is a heterodimer of a large (lys2) and a small subunit.; Function: lys2 of A. chrysogenum, as well as of S. cerevisiae, catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH.; Pathway: lysine biosynthesis.; Similarity: the C-terminal half of the predicted ORF shows similarity to the oxidoreductase portion of several poorly characterized poliketide or secondary metabolite sinthases.; Similarity: the N-terminal part of the predicted ORF shows no similarity to known proteins.; Title: similarity to aminoadipate reductase enzyme lys2 - Acremonium chrysogenum; See PMID 11254122; See PMID 3928261; uncharacterized protein 1042710 4984656 An11g04250 Aspergillus niger uncharacterized protein XP_001394420.3 1039385 R 5061 CDS An11g04260 4984657 complement(join(1043203..1043906,1043977..1044115)) VII 1 NT_166526.1 Similarity: the similarity to dihydrofolate reductase is limited to the N-terminal half of the protein.; Title: weak similarity to dihydrofolate reductase dfr1p - Schizosaccharomyces pombe; See PMID 8088538; uncharacterized protein 1044115 4984657 An11g04260 Aspergillus niger uncharacterized protein XP_001394421.1 1043203 R 5061 CDS An11g04270 4984658 complement(join(1045048..1045692,1045723..1046054,1046109..1046220)) VII 1 NT_166526.1 Catalytic activity: lovC of A. terreus probably acts as an enoyl reductase.; Function: lovC of A. terreus interacts with lovB in the biosynthesis of the lovastatin precursor dihydromonacolin L.; Remark: in A. terreus the genes involved in lovastatin biosynthesis are clustered.; Similarity: lovC of A. terreus belongs to the Zn-containing oxidoreductases family.; Similarity: the predicted ORF shows a much stronger similarity to toxD of C. carbonum, a gene unique to isolates that make the cyclic peptide HC-toxin, but which has no role in toxin biosyntehsis.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994; uncharacterized protein 1046220 4984658 An11g04270 Aspergillus niger uncharacterized protein XP_059601578.1 1045048 R 5061 CDS An11g04280 4984659 join(1046796..1046996,1047064..1047208,1047264..1047532,1047582..1047944,1047996..1048938,1048997..1052304,1052347..1053321,1053376..1054048,1054111..1054259) VII 1 NT_166526.1 Catalytic activity: polyketide synthases are multifunctional enzymes, containing oxidoreductase,transferase and dehydratase activity.; Function: PKS1 of C. heterostrophus is required for the biosynthesis of the polyketide T-toxin.; Pathway: polyketides are generated from acetate by a pathway similar to the fatty acid metabolism, where some reduction or dehydratation reactions can be suppressed at specific biosynthetic steps, resulting in a much wider range of products, constituting a large family of often biologically active secondary metabolites.; Similarity: the predicted ORF shows strong similarity to different fungal polyketide synthases, e. g. also to lovF of A. terreus, which is linked to lovC in the A. terreus genome.; Title: strong similarity to polyketide synthase PKS1 - Cochliobolus heterostrophus; See PMID 8953776; uncharacterized protein 1054259 4984659 An11g04280 Aspergillus niger uncharacterized protein XP_059601579.1 1046796 D 5061 CDS An11g04290 4984660 complement(join(1054359..1054567,1054662..1054813,1054883..1055083,1055162..1055379)) VII 1 NT_166526.1 Catalytic activity: alcohol dehydrogenases catalyze the reversible reaction alcohol + NAD(+) <=> aldehyde or ketone + NADH.; Cofactor: members of this family of alchool dehydrogenases use NAD as electron exchanger.; Complex: rbtD of K. aerogenes is a homotetramer.; Similarity: rbtD of K. aerogenes belongs to short-chain, zinc-independent alcohol dehydrogenase family.; Similarity: the predicted ORF shows strong similarity with a number of known and putative alcohol dehydrogenases, with very wide substrate specificities.; Title: strong similarity to ribitol dehydrogenase rbtD - Klebsiella aerogenes; See PMID 3904726; uncharacterized protein 1055379 4984660 An11g04290 Aspergillus niger uncharacterized protein XP_001394424.1 1054359 R 5061 CDS An11g04300 4984661 join(1056279..1056548,1056605..1058074) VII 1 NT_166526.1 hypothetical protein 1058074 4984661 An11g04300 Aspergillus niger hypothetical protein XP_001394425.1 1056279 D 5061 CDS An11g04310 4984662 complement(join(1058959..1059551,1059604..1059810,1059857..1060471,1060521..1060641,1060690..1060788,1060853..1060928,1060993..1061027,1061110..1061159,1061241..1061280)) VII 1 NT_166526.1 Function: STAM of H. sapiens is a component of a signaling pathway promoting c-myc induction and cell growth in response to cytokine stimulation of lymphocytes.; Function: STAM of H. sapiens is associated with Jak3 and Jak2 tyrosine kinases and phosphorylated by Jak3 and Jak2 upon stimulation with IL-2 and GM-CSF, respectively.; Similarity: STAM of H. sapiens, as well as the predicted ORF, contains an SH3 protein-protein interaction domain and a VHS domain, typical of proteins involved in membrane trafficking and signal transduction.; Similarity: the N-terminal part of the gene model is confirmed by identity to A. niger EST EMBLEST Acc. N. BE759424.; Similarity: the predicted ORF, in the N-terminal region, displays a very strong similarity to a putative protein of S. pombe; the last one shows similarity to human STAM too.; Title: strong similarity to signal transducing adaptor molecule STAM - Homo sapiens; See PMID 8780729; See PMID 9133424; uncharacterized protein 1061280 4984662 An11g04310 Aspergillus niger uncharacterized protein XP_001394426.1 1058959 R 5061 CDS An11g04320 4984663 complement(join(1062709..1062813,1062868..1063202,1063255..1063354,1063411..1065387)) VII 1 NT_166526.1 Function: STE20 of S. cerevisiae is needed for mating in haploid cells, induction of a mating-specific gene Fus1, induction of mating-specific morphologies, and pheromone-induced proliferation arrest.; Function: STE20 of S. cerevisiae is required to link the pheromone response G-protein signal to the downstream MAP-kinase cascade.; Similarity: the similarity of the predicted ORF to STE20 of S. cerevisiae is weak in the N-terminal region and particularly strong in the C-terminal part.; Similarity: to the conserved catalytic domains of Ser/Thr-protein kinases.; Title: strong similarity to serine/threonine kinase Ste20 - Saccharomyces cerevisiae; cytoplasm; See PMID 9024634; uncharacterized protein 1065387 4984663 An11g04320 Aspergillus niger uncharacterized protein XP_001394427.1 1062709 R 5061 CDS An11g04330 84592264 complement(join(1066968..1067214,1067319..1067451,1067601..1067744,1068491..1068506)) VII 1 NT_166526.1 Title: questionable ORF; uncharacterized protein 1068506 84592264 An11g04330 Aspergillus niger uncharacterized protein XP_059601580.1 1066968 R 5061 CDS An11g04340 4984665 complement(join(1070821..1071314,1071368..1072049,1072146..1072490)) VII 1 NT_166526.1 Catalytic activity: nucleobase (out) + H+ (out) --> nucleobase (in) + H+ (in).; Function: FCY2 of S. cerevisiae has a broad specificity towards purines, and also transport cytosine and 5-methylcytosine but neither uracil nor thymine.; Similarity: FCY2 of S. cerevisiae belongs to the nucleobase:cation symporter-1 family of transport proteins.; Title: strong similarity to cytosine/purine permease Fcy2 - Saccharomyces cerevisiae; plasma membrane; See PMID 1541283; See PMID 2191181; uncharacterized protein 1072490 4984665 An11g04340 Aspergillus niger uncharacterized protein XP_001394429.1 1070821 R 5061 CDS An11g04350 84592265 complement(join(1072588..1072747,1072863..1073012,1073483..1073677,1073859..1074107,1074220..1074680,1074803..1074895)) VII 1 NT_166526.1 hypothetical protein 1074895 84592265 An11g04350 Aspergillus niger hypothetical protein XP_059601581.1 1072588 R 5061 CDS An11g04360 4984667 join(1075140..1075524,1075575..1075843,1075913..1078205,1078263..1078834) VII 1 NT_166526.1 Complex: SCP160 of S. cerevisiae binds RNA and single-stranded and double stranded DNA, and is associated with polyribosome complexes.; Function: SCP160 of S. cerevisiae is implicated in mRNA metabolism.; Localization: SCP160 of S. cerevisiae, as well as its vertebrate homologues vigilins, is associated via ionic interactions with the nuclear envelope and the endoplasmic reticulum.; Phenotype: the most noteworthy phenotype of SCP160 deletion mutants in S. cerevisiae is a decrease in viability and an increased number of chromosomes in the surviving cells.; Similarity: SCP160 of S. cerevisiae contains 14 KH domains, conserved motifs that have been identified in a variety of RNA-binding proteins; the predicted ORF contains 8 KH domains.; Title: strong similarity to polyribosome binding protein Scp160 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 8533468; See PMID 9363784; See PMID 10710424; uncharacterized protein 1078834 4984667 An11g04360 Aspergillus niger uncharacterized protein XP_059601582.1 1075140 D 5061 CDS An11g04370 4984668 complement(join(1080039..1080209,1080278..1080404,1080589..1080707)) VII 1 NT_166526.1 Remark: A novel type of RNA editing, in which the cDNA included either guanine insertion or adenine-->guanine substitution at one base upstream of poly(A), was observed with cytochrome b5 from M. alpina. .; Remark: a splice site was detected upstream of the START codon.; Remark: strong similarity to A. niger EST an_2954.; Title: strong similarity to cytochrome b5 -Mortierella alpina; See PMID 10348912; uncharacterized protein 1080707 4984668 An11g04370 Aspergillus niger uncharacterized protein XP_001394432.1 1080039 R 5061 CDS An11g04380 84592266 complement(1082945..1085392) VII 1 NT_166526.1 Catalytic activity: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol.; Remark: acts on esters formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin. Also acts on AMP-ubiquitin.; Title: strong similarity to ubiquitin specific protease Ubp5 - Saccharomyces cerevisiae; See PMID 7871889; See PMID 11076031; uncharacterized protein 1085392 84592266 An11g04380 Aspergillus niger uncharacterized protein XP_059601583.1 1082945 R 5061 CDS An11g04390 4984669 complement(join(1085859..1086098,1086165..1086519,1086575..1086653,1086766..1086892)) VII 1 NT_166526.1 hypothetical protein 1086892 4984669 An11g04390 Aspergillus niger hypothetical protein XP_001394433.3 1085859 R 5061 CDS An11g04400 4984671 join(1087151..1087218,1087321..1087453,1087513..1087794,1087855..1088623,1088694..1089553) VII 1 NT_166526.1 Function: Vps27p in S. cerevisiae controls membrane traffic through the prevacuolar/endosomal compartment. S. cerevisiae Vps27p is a 'class E' protein involved in exit from the prevacuolar compartment. it is involved in forward transport to the vacuole as well as vesicle recycling to the Golgi.; Remark: Vps27p, like all class E proteins, probably participates in ubiquitin-mediated maturation of multivesicular bodies upon delivery to the yeast vacuole.; Title: strong similarity to vacuolar protein sorting-associated protein Vps27 - Saccharomyces cerevisiae; endosome; See PMID 10367894; See PMID 7593183; uncharacterized protein 1089553 4984671 An11g04400 Aspergillus niger uncharacterized protein XP_001394435.1 1087151 D 5061 CDS An11g04410 4984672 1090667..1092691 VII 1 NT_166526.1 Title: similarity to hypothetical Cys2/His2-type zinc finger protein T18C15_3 - Arabidopsis thaliana; uncharacterized protein 1092691 4984672 An11g04410 Aspergillus niger uncharacterized protein XP_059604297.1 1090667 D 5061 CDS An11g04420 4984673 complement(join(1093476..1095204,1095258..1095375,1095430..1097808,1097941..1098315,1098358..1098520)) VII 1 NT_166526.1 Title: strong similarity to protein mddt from patent WO200162922-A2 - Homo sapiens; uncharacterized protein 1098520 4984673 An11g04420 Aspergillus niger uncharacterized protein XP_059604298.1 1093476 R 5061 CDS An11g04450 84592267 complement(join(1101656..1101877,1102113..1102229,1102338..1102485,1102570..1102809,1102893..1103062)) VII 1 NT_166526.1 Remark: all homology proteins have a single repetitive block.; hypothetical protein 1103062 84592267 An11g04450 Aspergillus niger hypothetical protein XP_059604299.1 1101656 R 5061 CDS An11g04460 4984677 join(1103314..1103532,1103610..1103708,1103803..1106361) VII 1 NT_166526.1 Title: similarity to hypothetical protein SPAC4F10.07c - Schizosaccharomyces pombe; uncharacterized protein 1106361 4984677 An11g04460 Aspergillus niger uncharacterized protein XP_001394439.1 1103314 D 5061 CDS An11g04470 4984678 complement(join(1107380..1107657,1107750..1109696,1109757..1110108)) VII 1 NT_166526.1 Remark: similarity to protein fragment SEQ ID NO: 19254 patent EP1033405-A2.; Remark: the Arabidopsis thaliana sequence is a putative protein fragment.; Title: similarity to protein fragment SEQ ID NO:19254 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 1110108 4984678 An11g04470 Aspergillus niger uncharacterized protein XP_001394440.3 1107380 R 5061 CDS An11g04480 4984679 join(1110534..1110579,1110615..1110905,1110977..1113811,1113858..1114511,1114561..1115073,1115366..1115400) VII 1 NT_166526.1 Remark: RNA polymerase II holoenzymes have been described that consist of RNA polymerase II, a subset of general transcription factors, and four SRB proteins. The SRB proteins, which were identified through a selection for genes involved in transcription initiation by RNA polymerase II in vivo, are a hallmark of the holoenzyme.; Title: similarity to non-specific RNA polymerase II transcription factor Srb9 - Saccharomyces cerevisiae; See PMID 7774808; See PMID 8725217; uncharacterized protein 1115400 4984679 An11g04480 Aspergillus niger uncharacterized protein XP_059604300.1 1110534 D 5061 CDS An11g04500 4984681 join(1116596..1117146,1117238..1117307) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein B23L21.160 - Neurospora crassa; uncharacterized protein 1117307 4984681 An11g04500 Aspergillus niger uncharacterized protein XP_001394442.3 1116596 D 5061 CDS An11g04510 4984682 complement(join(1117604..1117675,1117733..1119844)) VII 1 NT_166526.1 Function: involved in translation termination. Stimulates the activity of erf1. Binds guanine nucleotides.; Remark: SUP2 (SUP35) is an omnipotent suppressor gene, coding for an EF-1 alpha-like protein factor,intimately involved in the control of translational accuracy in yeast S. cerevisiae.; Remark: alternative names are GST1, SUP35, SUP36,SUF12, PNM2, SAL3.; Similarity: to GTP-binding elongation factors.; Title: strong similarity to suppressor 2 Sup2 -Saccharomyces cerevisiae; See PMID 3047009; See PMID 3280807; uncharacterized protein 1119844 4984682 An11g04510 Aspergillus niger uncharacterized protein XP_001394443.1 1117604 R 5061 CDS An11g04520 4984683 join(1120494..1120514,1120571..1120602,1120667..1120724,1120802..1120905,1120964..1122776) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein B23I11.70 - Neurospora crassa; uncharacterized protein 1122776 4984683 An11g04520 Aspergillus niger uncharacterized protein XP_001394444.1 1120494 D 5061 CDS An11g04530 4984684 complement(join(1123364..1123665,1123733..1124717)) VII 1 NT_166526.1 Remark: the predicted ORF is related to DOS1 S. cerevisiae.; Title: similarity to hypothetical protein DOS1 -Neurospora crassa; uncharacterized protein 1124717 4984684 An11g04530 Aspergillus niger uncharacterized protein XP_001394445.1 1123364 R 5061 CDS An11g04540 4984685 complement(join(1125028..1127020,1127232..1127239)) VII 1 NT_166526.1 Protein sequence is in conflict with the conceptual translation; Similarity: to neurofilament proteins.; Title: similarity to hypothetical protein DKFZp434F1017 - Homo sapiens [putative sequencing error]; putative sequencing error; uncharacterized protein 1127239 4984685 An11g04540 Aspergillus niger uncharacterized protein XP_001394446.3 1125028 R 5061 CDS An11g04550 4984686 join(1127836..1127964,1128037..1128158,1128218..1128672,1128781..1129286) VII 1 NT_166526.1 Catalytic activity: Pyruvate + Lipoamide <=> S-Acetyldihydrolipoamide + CO2.; Cofactor: thiamin pyrophosphate.; Complex: the S. cerevisiae Pda1 protein is component of the multienzyme pyruvate dehydrogenase complex.; Function: the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-Coa & CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) & lipoamide dehydrogenase (E3).; Remark: alternative name for S. cerevisiae Pda1: YER178W.; Title: strong similarity to pyruvate dehydrogenase alpha subunit E1 alpha Pda1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 1330555; See PMID 2202601; uncharacterized protein 1129286 4984686 An11g04550 Aspergillus niger uncharacterized protein XP_059604301.1 1127836 D 5061 CDS An11g04560 84592268 complement(join(1131127..1131459,1131564..1131604,1131865..1131916)) VII 1 NT_166526.1 hypothetical protein 1131916 84592268 An11g04560 Aspergillus niger hypothetical protein XP_059604302.1 1131127 R 5061 CDS An11g04570 84592269 join(1132054..1132258,1132379..1132524,1132660..1132761,1132878..1132973) VII 1 NT_166526.1 hypothetical protein 1132973 84592269 An11g04570 Aspergillus niger hypothetical protein XP_059604303.1 1132054 D 5061 CDS An11g04580 84592270 complement(join(1132985..1133188,1133290..1133406,1133492..1133568,1133641..1133718,1133814..1134025,1134154..1134231,1134277..1134343,1134427..1134589,1134641..1134700)) VII 1 NT_166526.1 hypothetical protein 1134700 84592270 An11g04580 Aspergillus niger hypothetical protein XP_059604304.1 1132985 R 5061 CDS An11g04600 4984690 join(1139011..1139063,1139194..1139393,1139463..1140397) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein CAD21381.1 - Neurospora crassa; uncharacterized protein 1140397 4984690 An11g04600 Aspergillus niger uncharacterized protein XP_059604305.1 1139011 D 5061 CDS An11g04610 4984691 join(1141158..1141461,1141526..1143507) VII 1 NT_166526.1 Title: weak similarity to cytochrome P450 CYP73A from patent FR2768748-A1 - Triticum aestivum; uncharacterized protein 1143507 4984691 An11g04610 Aspergillus niger uncharacterized protein XP_001394452.1 1141158 D 5061 CDS An11g04620 4984692 complement(join(1143823..1144467,1144552..1144599,1144683..1144808)) VII 1 NT_166526.1 Complex: the yeast Proteasome is composed of 14 different subunits which form a highly ordered ring-shaped structure.; Function: the S. cerevisiae homolog Pup1p is the proteolytic active beta-2 proteasome subunit with a trypsin-like activity.; Localization: in S. cerevisiae the Proteasome is localized in the cytoplasm and in the nucleus.; Remark: the Proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.; Title: strong similarity to proteasome 20S subunit Pup1 - Saccharomyces cerevisiae; See PMID 9312134; See PMID 10393174; uncharacterized protein 1144808 4984692 An11g04620 Aspergillus niger uncharacterized protein XP_001394453.1 1143823 R 5061 CDS An11g04630 4984693 join(1145409..1145489,1145555..1146248,1146302..1147540,1147580..1149987) VII 1 NT_166526.1 Function: the human Nup214 protein is component of the nuclear pore complex. It is exposed to the cytoplasmic side. It serves as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.; Remark: alternate names for the human nuclear pore complex protein Nup214: can or cain.; Title: similarity to nuclear pore complex Nup214 -Homo sapiens; nucleus; See PMID 9141635; See PMID 9488438; uncharacterized protein 1149987 4984693 An11g04630 Aspergillus niger uncharacterized protein XP_059604306.1 1145409 D 5061 CDS An11g04640 4984694 join(1150409..1150595,1150719..1151248) VII 1 NT_166526.1 Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; hypothetical protein 1151248 4984694 An11g04640 Aspergillus niger hypothetical protein XP_001394455.1 1150409 D 5061 CDS An11g04650 4984695 complement(join(1151751..1152518,1152578..1153075)) VII 1 NT_166526.1 Function: the human alpha CP-1 protein is member of the KH domain RNA binding protein family. It is involved in formation of a sequence-specific alpha-globin mRNP complex associated with alpha-globin mRNA stability.; Similarity: the ORF DNA sequence shows strong similarity to the EST an_3511 from Aspergillus niger.; Title: similarity to alpha-complex protein 1 CP-1 -Homo sapiens; See PMID 7556077; uncharacterized protein 1153075 4984695 An11g04650 Aspergillus niger uncharacterized protein XP_001394456.3 1151751 R 5061 CDS An11g04660 4984696 join(1154100..1154285,1154362..1155225) VII 1 NT_166526.1 Title: similarity to hypothetical protein B8J22.100 - Neurospora crassa; uncharacterized protein 1155225 4984696 An11g04660 Aspergillus niger uncharacterized protein XP_001394457.1 1154100 D 5061 CDS An11g04670 4984697 complement(join(<1155466..1155986,1156035..1156113,1156166..1159788,1159849..1160273)) VII 1 NT_166526.1 Function: the QDE-3 protein from N. crassa is involved in the phenomenon of posttranscriptional gene silencing (PTGS), which occurs when a transgene is introduced into a cell. The QDE-3 protein may function in the DNA-DNA interaction between introduced transgenes or with an endogenous gene required for gene-silencing activation.; Remark: a putative sequencing error results in an frameshift.; Similarity: the ORF encoded protein and the N. crassa QDE-3 protein belong to the RecQ DNA helicase family.; Title: strong similarity to DNA helicase QDE-3 -Neurospora crassa [putative frameshift]; nucleus; putative frameshift; See PMID 10600745; uncharacterized protein 1160273 4984697 An11g04670 Aspergillus niger uncharacterized protein XP_001394458.3 1155466 R 5061 CDS An11g04680 4984699 join(1161098..1161542,1161602..1161747,1161800..>1161977) VII 1 NT_166526.1 Function: the dynein heavy chain alpha Oda11 from C. reinhardtii is the force generating protein of eukaryotic cilia and flagella. It produces force towards the minus ends of microtubules. Dynein has ATPase activity.; Remark: C-terminally truncated ORF due to the end of contig.; Similarity: the ORF encoded protein shows strong similarity to the proteins of unknown function BAB09450. 1 (A. thaliana) and YPL263c/Kel3 (S. cerevisiae).; Title: similarity to dynein heavy chain alpha Oda11 - Chlamydomonas reinhardtii [truncated ORF]; See PMID 9725897; uncharacterized protein 1161977 4984699 An11g04680 Aspergillus niger uncharacterized protein XP_001394460.3 1161098 D 5061 CDS An11g04690 84592271 <1162080..1163222 VII 1 NT_166526.1 Remark: N-terminally truncated ORF due to the end of contig.; Remark: alternate name for S. cerevisiae Kel3: YPL263c.; Similarity: the similarities of the ORF encoded protein to all matching proteins with an e-val less than 8e-13 are mainly based on repetitive structures.; Title: strong similarity to hypothetical protein Kel3 - Saccharomyces cerevisiae [truncated ORF]; uncharacterized protein 1163222 84592271 An11g04690 Aspergillus niger uncharacterized protein XP_059601584.1 1162080 D 5061 CDS An11g04700 4984700 join(1163996..1164047,1164162..1165105) VII 1 NT_166526.1 Catalytic activity: pyridoxine + NADP(+) <=> pyridoxal + NADPH.; Remark: alternate names for the S. pombe pyridoxine 4-dehydrogenase PLR : pyridoxal reductase; pyridoxin dehydrogenase; pyridoxine:NADP+ 4-oxidoreductase.; Title: strong similarity to pyridoxine 4-dehydrogenase PLR - Schizosaccharomyces pombe; See PMID 10438489; uncharacterized protein 1165105 4984700 An11g04700 Aspergillus niger uncharacterized protein XP_001394461.1 1163996 D 5061 CDS An11g04710 84592272 complement(join(1165218..1165327,1165414..1166539,1166602..1166661)) VII 1 NT_166526.1 Similarity: the ORF encoded protein shows significant domain homology to the transcriptional regulator UaY from Emericella nidulans and to other fungal transcription factors.; Title: similarity to positive regulator of purine utilisation uaY - Aspergillus nidulans; nucleus; See PMID 7729421; uncharacterized protein 1166661 84592272 An11g04710 Aspergillus niger uncharacterized protein XP_059601585.1 1165218 R 5061 CDS An11g04720 4984702 complement(1167067..1168581) VII 1 NT_166526.1 Catalytic activity: dihydroxy- L-phenylalanine (DOPA) <=> dopamine + CO(2).; Cofactor: Pyridoxal-phosphate.; Title: strong similarity to aromatic amino acid decarboxylase Ddc - Sorangium cellulosum; See PMID 10816050; uncharacterized protein 1168581 4984702 An11g04720 Aspergillus niger uncharacterized protein XP_001394463.1 1167067 R 5061 CDS An11g04730 4984703 join(1168881..1168897,1169058..1169225,1169345..1169630,1169688..1169932,1169996..1170081,1170133..1170297,1170349..1170369,1170419..1170557,1170615..1170711,1170789..1171100) VII 1 NT_166526.1 Function: the prolyl aminopeptidase PAP from Aeromonas sobria catalyzes release of a N-terminal proline from a peptide. The purified enzyme showed an almost absolute specificity for amino-terminal proline. Proline and hydroxyproline residues from many peptide and amide substrates could be easily removed, while no activity was detected for substrates having other amino terminals.; Gene-ID: papA; Remark: the matched sequence of papA from A. niger is identified by BLASTP against the new EMBL entry CAC40647.; Similarity: the prolyl aminopeptidase PAP from Aeromonas sobria belongs to peptidase family S33.; prolyl aminopeptidase papA-Aspergillus niger 1171100 papA 4984703 papA Aspergillus niger prolyl aminopeptidase papA-Aspergillus niger XP_059601586.1 1168881 D 5061 CDS An11g04740 4984704 complement(join(1171221..1171259,1171366..1171600,1171681..1171862,1171925..1172787,1172846..1173473)) VII 1 NT_166526.1 Similarity: the ORF encoded protein shows also a significant similarity hypothetical protein 'Sand' from Fugu rubripes.; Title: strong similarity to secreted protein SEQ ID NO:125 from patent WO200061624-A1 - Homo sapiens; uncharacterized protein 1173473 4984704 An11g04740 Aspergillus niger uncharacterized protein XP_059601587.1 1171221 R 5061 CDS An11g04750 4984705 join(1173913..1174003,1174075..1174199,1174262..1174411,1174485..1176721,1176816..1177045,1177097..1178562,1178614..1179876) VII 1 NT_166526.1 Remark: mutant strains with a temperature-sensitive dopA allele or with a null deltadopA allele, show abnormal morphology of the vegetative hyphae, delayed and asynchronous initiation of asexual development, aberrant morphogenesis of the conidiophore and an early block in the sexual cycle.; Similarity: DopA (E. nidulans) homologues from S. cerevisiae (Dop1), Candida albicans, Caenorhabditis elegans, Rattus norvegicus and Homo sapiens have been identified from genome sequencing projects.; Title: strong similarity to developmental regulator of asexual and sexual reproduction dopA - Aspergillus nidulans; See PMID 10931277; uncharacterized protein 1179876 4984705 An11g04750 Aspergillus niger uncharacterized protein XP_001394466.1 1173913 D 5061 CDS An11g04760 4984706 join(1180012..1180048,1180167..1180300,1180370..1180533,1180596..1180701,1180761..1180844) VII 1 NT_166526.1 Title: similarity to hypothetical protein EAA54961.1 - Magnaporthe grisea; uncharacterized protein 1180844 4984706 An11g04760 Aspergillus niger uncharacterized protein XP_001394467.3 1180012 D 5061 CDS An11g04770 4984707 join(1181332..1181599,1181671..1182256,1182408..1182552) VII 1 NT_166526.1 Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: weak similarity to neurofilament protein NF-220 - Loligo pealei; uncharacterized protein 1182552 4984707 An11g04770 Aspergillus niger uncharacterized protein XP_059601588.1 1181332 D 5061 CDS An11g04780 4984708 complement(join(1182672..1184291,1184347..1184414,1184473..1184734)) VII 1 NT_166526.1 Function: the Gup1 protein is essential for proton symport of glycerol into S. cerevisiae cells.; Remark: alternate name for S. cerevisiae Gup1: YGL084C.; Title: strong similarity to multimembrane-spanning protein involved in active glycerol uptake Gup1 -Saccharomyces cerevisiae; plasma membrane; See PMID 10931309; uncharacterized protein 1184734 4984708 An11g04780 Aspergillus niger uncharacterized protein XP_059601589.1 1182672 R 5061 CDS An11g04790 4984709 join(1185524..1185655,1185764..1185924,1185977..1186109) VII 1 NT_166526.1 Title: weak similarity to acylphosphatase Tu1 -Meleagris gallopavo; uncharacterized protein 1186109 4984709 An11g04790 Aspergillus niger uncharacterized protein XP_001394470.3 1185524 D 5061 CDS An11g04800 84592273 complement(join(1187014..1187137,1187243..1187311,1187386..1187534)) VII 1 NT_166526.1 Title: questionable ORF; uncharacterized protein 1187534 84592273 An11g04800 Aspergillus niger uncharacterized protein XP_059601590.1 1187014 R 5061 CDS An11g04810 4984711 join(1187982..1188235,1188289..1188579,1188629..1189139) VII 1 NT_166526.1 Function: the Aox1 enzyme from A. niger mediates cyanide-resistant oxygen consumption. It may increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.; Gene-ID: aox1; localisation:mitochondrion; See PMID 9933359; alternative oxidase aox1-Aspergillus niger 1189139 aox1 4984711 aox1 Aspergillus niger alternative oxidase aox1-Aspergillus niger XP_001394472.1 1187982 D 5061 CDS An11g04820 4984712 1190087..1191634 VII 1 NT_166526.1 hypothetical protein 1191634 4984712 An11g04820 Aspergillus niger hypothetical protein XP_001394473.1 1190087 D 5061 CDS An11g04830 4984713 1192883..1196098 VII 1 NT_166526.1 Title: strong similarity to hypothetical protein EAA64933.1 - Aspergillus nidulans; uncharacterized protein 1196098 4984713 An11g04830 Aspergillus niger uncharacterized protein XP_059601591.1 1192883 D 5061 CDS An11g04840 4984714 complement(join(1196393..1196560,1196623..1196732,1196814..1197177)) VII 1 NT_166526.1 Function: MPR1 of S. cerevisiae sigma 1278b confers resistance to the L-proline analogue L-azetidine-2-carboxylic acid.; Function: MPR1 of S. cerevisiae sigma 1278b encodes a hypothetical N-acetyltransferase.; Title: strong similarity to L-proline-analogue resistance gene Mpr1 - Saccharomyces cerevisiae; See PMID 10894734; uncharacterized protein 1197177 4984714 An11g04840 Aspergillus niger uncharacterized protein XP_001394475.1 1196393 R 5061 CDS An11g04850 84592274 1198306..1198584 VII 1 NT_166526.1 hypothetical protein 1198584 84592274 An11g04850 Aspergillus niger hypothetical protein XP_059601592.1 1198306 D 5061 CDS An11g04860 4984716 join(1198901..1199731,1199802..1199951) VII 1 NT_166526.1 Similarity: to N6-DNA-methyltransferases in different organisms.; Title: similarity to hypothetical protein YDR140w -Saccharomyces cerevisiae; uncharacterized protein 1199951 4984716 An11g04860 Aspergillus niger uncharacterized protein XP_001394477.3 1198901 D 5061 CDS An11g04870 4984717 complement(join(1200376..1200677,1200754..1200803,1200883..1200896)) VII 1 NT_166526.1 Remark: Sm-D exists in the cell as one of the core proteins of the small nuclear ribonucleoprotein complexes implicated in RNA processing.; Remark: the yeast homologue is associated with U1,U2, U4, U5, and U6 snRNA.; Similarity: to snRNA-associated proteins in different organisms.; Title: strong similarity to ribonucleoprotein autoantigen Sm-D - Homo sapiens; See PMID 11239461; See PMID 2528429; See PMID 3260384; uncharacterized protein 1200896 4984717 An11g04870 Aspergillus niger uncharacterized protein XP_001394478.1 1200376 R 5061 CDS An11g04880 4984718 complement(join(1201236..1201718,1201765..1203576,1203662..1204018)) VII 1 NT_166526.1 Remark: only a small part of the protein shows this similarity.; Title: weak similarity to hypothetical novel nuclear protein NNP-1 var - Mus musculus; uncharacterized protein 1204018 4984718 An11g04880 Aspergillus niger uncharacterized protein XP_059601593.1 1201236 R 5061 CDS An11g04890 84592275 complement(1204770..1207541) VII 1 NT_166526.1 Remark: Rpn5 encodes a multicatalytic endopeptidase regulator involved in proteolysis and peptidolysis which is a component of the 19S proteasome regulatory particle.; Similarity: to sequences from Caenorhabditis elegans, Homo sapiens and S. cerevisiae.; Title: similarity to multicatalytic endopeptidase regulator Rpn5 - Drosophila melanogaster; See PMID 10893261; uncharacterized protein 1207541 84592275 An11g04890 Aspergillus niger uncharacterized protein XP_059601594.1 1204770 R 5061 CDS An11g04900 4984720 complement(join(1208781..1209111,1209175..1209234,1209288..1209368,1209427..1209652,1209706..1209821,1209858..1210294)) VII 1 NT_166526.1 Remark: there is a weak similarity to extensin and polymerase like proteins cause of repetitiv elements of Serin and Prolin.; hypothetical protein 1210294 4984720 An11g04900 Aspergillus niger hypothetical protein XP_001394481.3 1208781 R 5061 CDS An11g04910 84592276 join(1213395..1213406,1213450..1213728) VII 1 NT_166526.1 hypothetical protein 1213728 84592276 An11g04910 Aspergillus niger hypothetical protein XP_059601595.1 1213395 D 5061 CDS An11g04920 84592277 complement(join(1214088..1214437,1214519..1214644,1214720..1214800,1214893..1214962,1215052..1215159,1215374..1215451,1216031..1216141)) VII 1 NT_166526.1 Remark: patent WO9907848-A1.; Remark: this polypeptide comprises the intracellular domain (residues 252-574) of human cytokine receptor 11 (Zcytor11), a novel class II cytokine receptor that appears to be a receptor for a helical cytokine of the interferon/interleukin-10 class.; Title: weak similarity to cytokine receptor 11 intracellular domain Zcytor11 from patent WO9907848-A1 -Homo sapiens; uncharacterized protein 1216141 84592277 An11g04920 Aspergillus niger uncharacterized protein XP_059601596.1 1214088 R 5061 CDS An11g04930 4984723 complement(join(1217623..1217766,1217816..1217841,1217900..1217983,1218184..1218559,1218610..1218768)) VII 1 NT_166526.1 hypothetical protein 1218768 4984723 An11g04930 Aspergillus niger hypothetical protein XP_059601597.1 1217623 R 5061 CDS An11g04935 84592278 complement(join(1219156..1219235,1219288..1219347,1219590..1220916)) VII 1 NT_166526.1 hypothetical protein 1220916 84592278 An11g04935 Aspergillus niger hypothetical protein XP_059601598.1 1219156 R 5061 CDS An11g04940 4984725 complement(join(1222661..1223187,1223240..1223294,1223355..1223874,1223921..1224073,1224123..1224242,1224296..1224494,1224549..1224656,1224767..1224848,1225079..1225495,1225577..1225621,1225788..1225936,1226218..1226297,1226414..1226535)) VII 1 NT_166526.1 Catalytic activity: Acyl-CoA + O2 = trans-2,3-Dehydroacyl-CoA + H2O2.; Pathway: fatty acid metabolism.; Remark: the macrolide antibiotic tylosin is composed of a polyketide lactone substituted with three deoxyhexose sugars.; Title: similarity to acyl-CoA oxydase tylP -Streptomyces fradiae; See PMID 10220165; See PMID 10333459; See PMID 10467127; uncharacterized protein 1226535 4984725 An11g04940 Aspergillus niger uncharacterized protein XP_001394486.3 1222661 R 5061 CDS An11g04950 84592279 complement(join(1227144..1227512,1227641..1227879,1227974..1228007)) VII 1 NT_166526.1 hypothetical protein 1228007 84592279 An11g04950 Aspergillus niger hypothetical protein XP_059601599.1 1227144 R 5061 CDS An11g04960 84592280 complement(join(1228060..1228190,1228648..1228813,1228922..1229004,1229138..1229274,1229437..1229480,1229613..1229861,1229954..1229992)) VII 1 NT_166526.1 Title: weak similarity to hypothetical trans-activating transcription regulator tat - Human T-cell lymphotropic virus type 2; uncharacterized protein 1229992 84592280 An11g04960 Aspergillus niger uncharacterized protein XP_059601600.1 1228060 R 5061 CDS An11g04970 4984728 complement(join(1231165..1231818,1231875..1232038,1232089..1232362)) VII 1 NT_166526.1 Title: weak similarity to immunodominant 45-55K antigen - Pneumocystis carinii; uncharacterized protein 1232362 4984728 An11g04970 Aspergillus niger uncharacterized protein XP_001394489.1 1231165 R 5061 CDS An11g04980 84592281 complement(join(1233581..1233650,1233715..1234623,1234843..>1235114)) VII 1 NT_166526.1 Remark: Yrb4p and Pse1p specifically bind to Gsp1p-GTP, protecting it from GTP hydrolysis and nucleotide exchange. The GTPase block of Gsp1p complexed to Yrb4p or Pse1p is released by Yrb1p, which contains a Gsp1p binding domain distinct from that of Yrb4p.; Remark: putative N-terminal truncated ORF due to end of contig.; Similarity: the yeast protein belongs to the RanBP7/importin-beta/Cse1p superfamily.; Title: similarity to RAN-binding protein Kap123 -Saccharomyces cerevisiae [truncated ORF]; See PMID 9321403; See PMID 10078529; uncharacterized protein 1235114 84592281 An11g04980 Aspergillus niger uncharacterized protein XP_059601601.1 1233581 R 5061 CDS An11g04990 4984730 complement(join(<1235217..1237180,1237245..1237290)) VII 1 NT_166526.1 Remark: C-terminal truncated ORF due to end of contig.; Remark: Yrb4p and Pse1p specifically bind to Gsp1p-GTP, protecting it from GTP hydrolysis and nucleotide exchange. The GTPase block of Gsp1p complexed to Yrb4p or Pse1p is released by Yrb1p, which contains a Gsp1p binding domain distinct from that of Yrb4p.; Similarity: belongs to the RanBP7/importin-beta/Cse1p superfamily.; Title: similarity to RAN-binding protein Kap123 -Saccharomyces cerevisiae [truncated ORF]; See PMID 9321403; See PMID 10078529; uncharacterized protein 1237290 4984730 An11g04990 Aspergillus niger uncharacterized protein XP_001394491.3 1235217 R 5061 CDS An11g05000 4984731 complement(join(1238268..1238371,1238433..1241886,1241950..1242225)) VII 1 NT_166526.1 Remark: Niemann-Pick C (NPC) disease is a recessive cholesterol storage disorder characterized by severe,progressive neurodegeneration.; Remark: also strong similarity to Niemann-Pick C1 protein homologe S. cerevisiae patent WO9901555-A1.; Remark: subcellular localization studies have shown NPC1 to reside in late endosomes and to transiently associate with lysosomes and the trans-Golgi network.; Similarity: to yeast, worm and murine NPC1 proteins.; Title: strong similarity to Niemann-Pick C1 protein - Homo sapiens; See PMID 11001808; See PMID 10425213; uncharacterized protein 1242225 4984731 An11g05000 Aspergillus niger uncharacterized protein XP_001394492.1 1238268 R 5061 CDS An11g05010 4984732 join(1244364..1244456,1244519..1245625,1245678..1245802,1246006..1246087) VII 1 NT_166526.1 Catalytic activity: ATP + a Protein = ADP + a Phosphoprotein.; Remark: ayk1 is specifically expressed in meiotically active cells, and during spermatogenesis, ayk1 transcripts accumulate just before the first meiotic division.; Similarity: to IPL1 and aurora related kinases.; Title: strong similarity to protein kinase ayk1 -Xenopus laevis; deleted EC_number 2.7.1.37; See PMID 9205101; uncharacterized protein 1246087 4984732 An11g05010 Aspergillus niger uncharacterized protein XP_001394493.3 1244364 D 5061 CDS An11g05030 84592282 complement(join(1246774..1247048,1247111..1247221,1247357..1248167,1248286..1248714)) VII 1 NT_166526.1 Similarity: has weak similarity to a hypothetical disease resistance protein from A. thaliana; Title: strong similarity to hypothetical protein encoded by An01g07930 - Aspergillus niger; uncharacterized protein 1248714 84592282 An11g05030 Aspergillus niger uncharacterized protein XP_059605493.1 1246774 R 5061 CDS An11g05040 84592283 join(1248733..1248783,1248865..1248963) VII 1 NT_166526.1 hypothetical protein 1248963 84592283 An11g05040 Aspergillus niger hypothetical protein XP_059605494.1 1248733 D 5061 CDS An11g05050 84592284 complement(join(1249212..1249307,1249369..1249476)) VII 1 NT_166526.1 Title: weak similarity to hypothetical protein APE0804 - Aeropyrum pernix; uncharacterized protein 1249476 84592284 An11g05050 Aspergillus niger uncharacterized protein XP_059605495.1 1249212 R 5061 CDS An11g05060 4984737 1249933..1251279 VII 1 NT_166526.1 Function: TRI101 of F. sporotrichioides converts isotrichodermol to isotrichodermin and is required for the biosynthesis of the trichothecene T-2 toxin.; Function: transfection of TRI101 of F. sporotrichioides into S. cerevisiae, protects the cell from the trichothecene 4,15-diacetoxyscirpenol. Antibiotic-producing organisms, including fungi, protect themselves from their own toxins by e. g. metabolic alteration of the compound.; Remark: trichothecenes are sesquiterpene epoxide mycotoxins produced by species of Fusarium, Trichothecium,and Myrothecium and act as potent inhibitors of eukaryotic protein synthesis.; Title: similarity to trichothecene 3-O-acetyltransferase TRI101 - Fusarium sporotrichioides; See PMID 10583973; uncharacterized protein 1251279 4984737 An11g05060 Aspergillus niger uncharacterized protein XP_001394497.1 1249933 D 5061 CDS An11g05070 84592285 join(1251785..1251877,1252014..1252241,1252288..1252338) VII 1 NT_166526.1 hypothetical protein 1252338 84592285 An11g05070 Aspergillus niger hypothetical protein XP_059605496.1 1251785 D 5061 CDS An11g05080 84592286 complement(join(1252450..1252488,1252572..1252722,1252826..1252938)) VII 1 NT_166526.1 Similarity: shows some similarity to N-terminal half of Atp7p of S. cerevisiae.; Title: weak similarity to H+-transporting ATP synthase chain d Atp7 - Saccharomyces cerevisiae; uncharacterized protein 1252938 84592286 An11g05080 Aspergillus niger uncharacterized protein XP_059605497.1 1252450 R 5061 CDS An11g05090 84592287 join(1252970..1253317,1253398..1253551,1253660..1253856,1253908..1253973) VII 1 NT_166526.1 hypothetical protein 1253973 84592287 An11g05090 Aspergillus niger hypothetical protein XP_059605498.1 1252970 D 5061 CDS An11g05100 4984741 complement(join(1254202..1254234,1254283..1255717,1255780..1255835)) VII 1 NT_166526.1 Similarity: shows match against EST (EMBLEST:AN791) of A. niger.; Similarity: the ORF encoded protein shows also weak similarity to protein kinase 6 from Glycine max.; Title: strong similarity to hypothetical protein encoded by An07g04880 - Aspergillus niger; uncharacterized protein 1255835 4984741 An11g05100 Aspergillus niger uncharacterized protein XP_001394501.1 1254202 R 5061 CDS An11g05110 4984742 join(1256351..1256515,1256578..1257171,1257233..1258018,1258177..1258299) VII 1 NT_166526.1 Remark: protein contains both protein kinase domain (N-terminal) and ankyrin repeats (C-terminal part).; Similarity: shows similarity to N-terminal part of human DAPK1.; Title: similarity to death-associated protein kinase DAPK1 - Homo sapiens; uncharacterized protein 1258299 4984742 An11g05110 Aspergillus niger uncharacterized protein XP_059605499.1 1256351 D 5061 CDS An11g05120 4984743 complement(join(1258785..1260217,1260256..1260266,1260572..1260606)) VII 1 NT_166526.1 Similarity: the ORF encoded protein shows also weak similarity to hypothetical protein T16H5. 30 from Arabidopsis thaliana.; Title: weak similarity to hypothetical protein T16H5.30 - Arabidopsis thaliana; uncharacterized protein 1260606 4984743 An11g05120 Aspergillus niger uncharacterized protein XP_059605500.1 1258785 R 5061 CDS An11g05130 4984744 complement(join(1262706..1262778,1262930..1263351,1263419..1263625,1263688..1264365)) VII 1 NT_166526.1 Catalytic activity: salicylate + NADH + O2 = catechol + NAD+ + H2O + CO2.; Function: NahG from P. stutzeri is a flavoprotein monooxygenase that catalyzes the conversion of salicylate to catechol.; Pathway: nahpthalene, salicylate, and phenylalanine metabolism.; Remark: the nahG gene of P. stutzeri is induced and expressed upon incubation with salicylate, the geneproduct is involved in naphthalene and salicylate metabolism.; Title: strong similarity to salicylate hydroxylase nahW - Pseudomonas stutzeri; See PMID 10197990; See PMID 10713446; uncharacterized protein 1264365 4984744 An11g05130 Aspergillus niger uncharacterized protein XP_001394504.3 1262706 R 5061 CDS An11g05140 84592288 join(1264426..1264615,1264769..1264850,1264947..1265018,1265115..1265184,1265258..1265392) VII 1 NT_166526.1 Similarity: shows similarity to N-terminal part of nodulation protein B from Rhizobium sp.; Title: weak similarity to nodulation protein B -Rhizobium sp.; uncharacterized protein 1265392 84592288 An11g05140 Aspergillus niger uncharacterized protein XP_059605501.1 1264426 D 5061 CDS An11g05150 84592289 complement(join(1265551..1265952,1266023..1266046)) VII 1 NT_166526.1 hypothetical protein 1266046 84592289 An11g05150 Aspergillus niger hypothetical protein XP_059605502.1 1265551 R 5061 CDS An11g05160 84592290 join(1266217..1266374,1266482..1266682,1266775..1266952,1266993..1267121) VII 1 NT_166526.1 Similarity: weak similarity to homeotic protein Hox C5 from H. sapiens.; Title: weak similarity to homeotic protein Hox C5 -Homo sapiens; uncharacterized protein 1267121 84592290 An11g05160 Aspergillus niger uncharacterized protein XP_059605503.1 1266217 D 5061 CDS An11g05170 84592291 complement(join(1267289..1267450,1267580..1268044)) VII 1 NT_166526.1 hypothetical protein 1268044 84592291 An11g05170 Aspergillus niger hypothetical protein XP_059605504.1 1267289 R 5061 CDS An11g05180 4984749 join(1269771..1269921,1269978..1270129,1270189..1270596,1270657..1271292,1271393..1271572) VII 1 NT_166526.1 Title: strong similarity to lovF gene expression regulator At286 from patent WO200257456-A2 - Unclassified organism; uncharacterized protein 1271572 4984749 An11g05180 Aspergillus niger uncharacterized protein XP_059606714.1 1269771 D 5061 CDS An11g05190 4984750 complement(1271825..1272853) VII 1 NT_166526.1 Similarity: shows similarity to N-terminal part of guaA of E. coli.; Title: weak similarity to glutamine-hydrolyzing GMP synthase guaA - Escherichia coli; uncharacterized protein 1272853 4984750 An11g05190 Aspergillus niger uncharacterized protein XP_001394510.1 1271825 R 5061 CDS An11g05200 84592292 join(1273533..1273589,1273683..1273750,1273863..1273912,1274571..1274682,1274763..1274822,1274877..1275012) VII 1 NT_166526.1 Remark: questionable ORF due to genestructure.; Title: questionable ORF; uncharacterized protein 1275012 84592292 An11g05200 Aspergillus niger uncharacterized protein XP_059606715.1 1273533 D 5061 CDS An11g05220 84592293 complement(join(1275574..1275626,1275786..1275881,1275951..1276026)) VII 1 NT_166526.1 Remark: questionable ORF due to genestructure.; Title: questionable ORF; uncharacterized protein 1276026 84592293 An11g05220 Aspergillus niger uncharacterized protein XP_059606716.1 1275574 R 5061 CDS An11g05230 4984754 join(1276650..1276925,1276991..1277256,1277320..1277580,1277645..1278008) VII 1 NT_166526.1 Title: similarity to hypothetical protein PA1213 -Pseudomonas aeruginosa; uncharacterized protein 1278008 4984754 An11g05230 Aspergillus niger uncharacterized protein XP_001394513.1 1276650 D 5061 CDS An11g05240 4984755 complement(join(1278169..1280490,1280552..1281073)) VII 1 NT_166526.1 Complex: the anaphase-promoting complex is composed of eight protein subunits, including BimE (APC1), CDC27 (APC3), CDC16 (APC6), and CDC23 (APC8).; Function: the APC2 gene is essential in S. cerevisiae, and yeast apc2 mutants arrest at metaphase and are defective in the degradation of Pds1p. APC2 and cullins may be distantly related members of a ubiquitin ligase family that targets cell cycle regulators for degradation.; Similarity: human APC2 contains a region that is similar to a sequence in cullins, a family of proteins implicated in the ubiquitination of G1 phase cyclins and cyclin-dependent kinase inhibitors.; Title: strong similarity to anaphase-promoting complex subunit 2 APC2 - Homo sapiens; uncharacterized protein 1281073 4984755 An11g05240 Aspergillus niger uncharacterized protein XP_001394514.1 1278169 R 5061 CDS An11g05260 4984756 complement(<1282289..1282795) VII 1 NT_166526.1 Remark: a splice site was detected upstream of the START codon.; Remark: the systematic gene name of S. cerevisiae PKR1 is YMR123W.; Title: strong similarity to Pichia farinosa killer toxin resistance protein Pkr1 - Saccharomyces cerevisiae; uncharacterized protein 1282795 4984756 An11g05260 Aspergillus niger uncharacterized protein XP_001394515.3 1282289 R 5061 CDS An11g05270 84592294 complement(join(1283707..1283888,1284110..1284218,1284354..1284528,1284603..1284688,1284778..1284795)) VII 1 NT_166526.1 hypothetical protein 1284795 84592294 An11g05270 Aspergillus niger hypothetical protein XP_059606717.1 1283707 R 5061 CDS An11g05280 4984758 join(1284886..1285408,1285488..1285960,1286023..1286368,1286427..1286503,1286564..1286803) VII 1 NT_166526.1 Similarity: shows strong similarity to several known and hypothetical sugar transporters.; Title: strong similarity to sugar transporter Sut1 -Pichia stipitis; plasma membrane; uncharacterized protein 1286803 4984758 An11g05280 Aspergillus niger uncharacterized protein XP_001394517.1 1284886 D 5061 CDS An11g05300 84592295 1287097..1288542 VII 1 NT_166526.1 Remark: putative pseudogene, since several in frame STOP codons are present.; Title: strong similarity to transposase of transposable element Tan1 - Aspergillus niger [putative pseudogene]; putative pseudogene; uncharacterized protein 1288542 84592295 An11g05300 Aspergillus niger uncharacterized protein XP_059606718.1 1287097 D 5061 CDS An11g05310 4984760 join(1289042..1289140,1289193..1289305,1289375..1290188,1290288..1290320,1290358..1291082,1291140..1291395) VII 1 NT_166526.1 Function: the prnA gene of A. nidulans codes for a transcriptional activator that mediates proline induction of four other genes involved in proline utilization as a nitrogen and/or carbon source in A. nidulans.; Title: similarity to transcription activator prnA -Aspergillus nidulans; See PMID 9622360; See PMID 10788322; uncharacterized protein 1291395 4984760 An11g05310 Aspergillus niger uncharacterized protein XP_059606719.1 1289042 D 5061 CDS An11g05320 4984761 complement(join(1292467..1292994,1293049..1293312)) VII 1 NT_166526.1 Complex: teh mediator complex is a subcomplex of the RNA polymerase II holoenzyme.; Complex: the S. cerevisiae mediator complex can be dissociated into two stable subcomplexes: the Rgr1-associated subcomplex: Rgr1p, Gal11p, Sin4p,Med3p/Pgd1p, Srb7p, Med1p, Med4p, Med7p, Med8p, Med9p; the Med6-containing subcomplex: Srb4p, Srb2p, Srb5p, Srb6p,Med6p, Rox3p.; Remark: the systematic genename of S. cerevisiae YOL135c is MED7.; Title: strong similarity to mediator complex subunit Med7 - Saccharomyces cerevisiae; nucleus; See PMID 9420330; uncharacterized protein 1293312 4984761 An11g05320 Aspergillus niger uncharacterized protein XP_001394520.1 1292467 R 5061 CDS An11g05330 4984762 join(1293677..1293754,1293820..1293907,1293971..1294310,1294363..1294735) VII 1 NT_166526.1 Function: DGPP phosphatase Dpp1p of S. cerevisiae is a membrane-associated 34-kDa enzyme which catalyzes the dephosphorylation of DGPP to yield phosphatidate (PA) and then catalyzes the dephosphorylation of PA to yield diacylglycerol.; Title: strong similarity to diacylglycerol pyrophosphate phosphatase Dpp1 - Saccharomyces cerevisiae; See PMID 11016943; See PMID 11139591; uncharacterized protein 1294735 4984762 An11g05330 Aspergillus niger uncharacterized protein XP_059606720.1 1293677 D 5061 CDS An11g05340 4984763 complement(join(1294910..1295130,1295191..1296283)) VII 1 NT_166526.1 Function: amadoriase (fructosyl amine oxygen oxidoreductase) is an enzyme catalyzing the oxidative deglycation of Amadori products to yield corresponding amino acids, glucosone, and H2O2.; Similarity: almost identical to Aspergillus fumigatus protein.; Title: strong similarity to fructosyl amine oxygen oxidoreductase - Aspergillus fumigatus; uncharacterized protein 1296283 4984763 An11g05340 Aspergillus niger uncharacterized protein XP_001394522.1 1294910 R 5061 CDS An11g05350 4984764 join(1297346..1297618,1297671..1297907,1297969..1298115,1298242..1298370,1298437..1298943,1298975..1299208,1299266..1299319,1299377..1299458,1299513..1299629,1299687..1299871,1299927..1299977,1300034..1300267) VII 1 NT_166526.1 Similarity: shows also similarity to Opt1p of S. cerevisiae.; Similarity: shows similarity to yeast and other eukaryotic isp4 proteins involved in sexual differentiation processes.; Title: similarity to oligopeptide transporter OPT1 -Candida albicans; uncharacterized protein 1300267 4984764 An11g05350 Aspergillus niger uncharacterized protein XP_059606721.1 1297346 D 5061 CDS An11g05380 4984767 join(1300872..1300907,1300995..1301321,1301405..1303192) VII 1 NT_166526.1 Similarity: only N-terminal half shows similarity to transcriptional activators.; Title: similarity to transcription activator of lysine pathway Lys14 - Saccharomyces cerevisiae; nucleus; uncharacterized protein 1303192 4984767 An11g05380 Aspergillus niger uncharacterized protein XP_059606722.1 1300872 D 5061 CDS An11g05390 4984768 complement(join(1303598..1306792,1306872..1306928,1306984..1307517)) VII 1 NT_166526.1 Similarity: only C-terminal part shows some similarity to C-terminal part of the Synechocystis ORF.; Title: similarity to hypothetical protein BAC69913.1 - Streptomyces avermitilis; uncharacterized protein 1307517 4984768 An11g05390 Aspergillus niger uncharacterized protein XP_059606723.1 1303598 R 5061 CDS An11g05400 4984769 complement(join(1307939..1309830,1310065..1310221,1310311..1310535,1310785..1313706,1313740..1313850,1313911..1313964,1314020..1314559)) VII 1 NT_166526.1 Similarity: the ORF encoded protein shows also weak similarity to hypothetical protein YOR197w from S. cerevisiae.; Title: weak similarity to metacaspase casA -Aspergillus nidulans; uncharacterized protein 1314559 4984769 An11g05400 Aspergillus niger uncharacterized protein XP_059606724.1 1307939 R 5061 CDS An11g05410 84592296 join(1316015..1316102,1316187..1316447,1316519..1316754,1316800..1317083,1317153..1317192) VII 1 NT_166526.1 Title: weak similarity to hypothetical protein yddE - Bacillus subtilis; uncharacterized protein 1317192 84592296 An11g05410 Aspergillus niger uncharacterized protein XP_059606725.1 1316015 D 5061 CDS An11g05420 4984771 complement(1317583..1321575) VII 1 NT_166526.1 Similarity: only C-terminal part shows some similarity to C-terminal part of the Synechocystis ORF.; Title: similarity to hypothetical protein BAC69913.1 - Streptomyces avermitilis; uncharacterized protein 1321575 4984771 An11g05420 Aspergillus niger uncharacterized protein XP_001394528.3 1317583 R 5061 CDS An11g05430 4984772 join(1323223..1323262,1323440..1324761) VII 1 NT_166526.1 Title: similarity to hypothetical protein encoded by An01g01140 - Aspergillus niger; uncharacterized protein 1324761 4984772 An11g05430 Aspergillus niger uncharacterized protein XP_001394529.3 1323223 D 5061 CDS An11g05440 4984773 complement(join(1325051..1325107,1325176..1325381,1325476..1325563)) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein MUTT - Arabidopsis thaliana; uncharacterized protein 1325563 4984773 An11g05440 Aspergillus niger uncharacterized protein XP_059606726.1 1325051 R 5061 CDS An11g05450 4984774 join(1326753..1326957,1327033..1328195,1328243..1329031) VII 1 NT_166526.1 hypothetical protein 1329031 4984774 An11g05450 Aspergillus niger hypothetical protein XP_059606727.1 1326753 D 5061 CDS An11g05460 4984775 join(1329449..1329505,1329573..1329591,1329678..1329793,1329849..1329938,1329987..1330056,1330092..1330236,1330287..1330628,1330740..1330786,1330863..1331044,1331139..1331204,1331291..>1331695) VII 1 NT_166526.1 Function: F-actin capping proteins bind to the fast growing ends of F-actin thereby blocking subunit exchange at these ends.; Remark: truncated due to end of contig.; Title: strong similarity to F-actin capping protein alpha-1 subunit CapZ - Mus musculus [truncated ORF]; cytoskeleton; uncharacterized protein 1331695 4984775 An11g05460 Aspergillus niger uncharacterized protein XP_059606728.1 1329449 D 5061 CDS An11g05470 84592297 complement(<1331803..1332869) VII 1 NT_166526.1 Remark: C-terminally truncated due to end of contig.; Title: strong similarity to hypothetical protein encoded by An15g04790 - Aspergillus niger [truncated ORF]; uncharacterized protein 1332869 84592297 An11g05470 Aspergillus niger uncharacterized protein XP_059601602.1 1331803 R 5061 CDS An11g05480 4984777 complement(join(1333863..1334128,1334189..1334498,1334533..1334614,1334668..1334888,1334942..1335012,1335069..1335102)) VII 1 NT_166526.1 Title: similarity to hypothetical isoflavone reductase-like NAD(P)H-dependent oxidoreductase IRL1 -Medicago sativa; uncharacterized protein 1335102 4984777 An11g05480 Aspergillus niger uncharacterized protein XP_059601603.1 1333863 R 5061 CDS An11g05490 4984778 complement(join(1335513..1335615,1335645..1335815,1335866..1335954)) VII 1 NT_166526.1 hypothetical protein 1335954 4984778 An11g05490 Aspergillus niger hypothetical protein XP_059601604.1 1335513 R 5061 CDS An11g05500 4984779 join(1338034..1339049,1339100..1340102,1340152..1341279) VII 1 NT_166526.1 Catalytic activity: l-2-aminoadipate 6-semialdehyde + NADP(+) + H(2)O = l-2-aminoadipate + NADPH.; Cofactor: contains a covalently bound phosphopantetheine; Function: lys1 from S. pombe catalyses the sixth step in lysine biosynthesis.; Function: lys1 from S. pombe catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH.; Title: similarity to aminoadipate-semialdehyde dehydrogenase lys1p - Schizosaccharomyces pombe; uncharacterized protein 1341279 4984779 An11g05500 Aspergillus niger uncharacterized protein XP_001394536.1 1338034 D 5061 CDS An11g05510 4984780 join(1342546..1342635,1342699..1343151,1343208..1343880,1343938..1344143) VII 1 NT_166526.1 Alternative name: FK506/rapamycin-binding protein FPR3; immunophilin FKBP-70; proline rotamase; prolyl cis-trans isomerase NPI46; protein YML074c.; Catalytic activity: peptidyl-prolyl cis-trans isomerases catalyze the conversion of cis-trans isomerization of proline imidic peptide bonds in oligopeptides.; Title: strong similarity to peptidyl-prolyl isomerase Fpr3 - Saccharomyces cerevisiae; nucleus; uncharacterized protein 1344143 4984780 An11g05510 Aspergillus niger uncharacterized protein XP_001394537.1 1342546 D 5061 CDS An11g05520 4984781 join(1345144..1346031,1346182..1346907,1346960..1347022,1347077..1347195,1347310..1347802) VII 1 NT_166526.1 Function: the Ustilago homologe plays a role in morphogenesis.; Title: similarity to serine/threonine protein kinase Ukc1p - Ustilago maydis; uncharacterized protein 1347802 4984781 An11g05520 Aspergillus niger uncharacterized protein XP_059601605.1 1345144 D 5061 CDS An11g05530 4984782 complement(join(1348969..1349233,1349322..1349378,1349432..1349567,1349625..1352478)) VII 1 NT_166526.1 Alternative name: the systematic gene name of TAFII145 of S. cerevisiae is YGR274c.; Similarity: the N-terminal 220 amino acids of the predicted ORF are not aligned.; Title: strong similarity to subunit of transcription initiation factor TFIID Tafii145 - Saccharomyces cerevisiae; nucleus; See PMID 7667272; uncharacterized protein 1352478 4984782 An11g05530 Aspergillus niger uncharacterized protein XP_059601606.1 1348969 R 5061 CDS An11g05540 84592298 join(1355311..1355374,1355419..1355511,1355581..1355721,1355823..1355951,1356037..1356074,1356136..1356351,1356412..1356657) VII 1 NT_166526.1 hypothetical protein 1356657 84592298 An11g05540 Aspergillus niger hypothetical protein XP_059601607.1 1355311 D 5061 CDS An11g05550 4984784 complement(1357107..1358762) VII 1 NT_166526.1 Similarity: shows similarity to several hypothetical major facilitator transporter homologs of different organisms.; Title: similarity to hypothetical major facilitator transporter Mfs1.1 - Coprinus cinereus; plasma membrane; uncharacterized protein 1358762 4984784 An11g05550 Aspergillus niger uncharacterized protein XP_001394541.1 1357107 R 5061 CDS An11g05560 4984785 complement(join(1359150..1359611,1359642..1359784,1359839..1360604)) VII 1 NT_166526.1 Catalytic activity: 8-Amino-7-oxononanoate synthases catalyze the conversion of 6-Carboxyhexanoyl-CoA + L-Alanine = 8-Amino-7-oxononanoate + CoA + CO2; Pathway: 8-Amino-7-oxononanoate synthases are involved in the biotin biosynthesis.; Title: similarity to 8-amino-7-oxononanoate synthase bioF - Bacillus sphaericus; See PMID 1575677; uncharacterized protein 1360604 4984785 An11g05560 Aspergillus niger uncharacterized protein XP_059601608.1 1359150 R 5061 CDS An11g05570 4984786 join(1361551..1362122,1362191..1367045,1367048..1367332,1367392..1367807,1367880..1369260) VII 1 NT_166526.1 Function: the Gibberella polyketide synthase is required for fumonisin biosynthesis.; Similarity: shows similarity to several polyketide synthases with different specificities.; Title: strong similarity to polyketide synthase FUM5 - Gibberella moniliformis; uncharacterized protein 1369260 4984786 An11g05570 Aspergillus niger uncharacterized protein XP_059601609.1 1361551 D 5061 CDS An11g05580 4984787 complement(join(1370636..1370844,1370913..1372127,1372187..1372529)) VII 1 NT_166526.1 Catalytic activity: glucose oxidases catalyze the conversion of beta-D-Glucose + O(2) = D-Glucono-1,5-Lactone + H(2)O(2).; Title: strong similarity to glucose oxidase GOD -Penicillium amagasakiense; uncharacterized protein 1372529 4984787 An11g05580 Aspergillus niger uncharacterized protein XP_001394544.1 1370636 R 5061 CDS An11g05590 84592299 join(1373007..1373130,1373272..1373388,1373499..1373587) VII 1 NT_166526.1 hypothetical protein 1373587 84592299 An11g05590 Aspergillus niger hypothetical protein XP_059601610.1 1373007 D 5061 CDS An11g05600 4984789 complement(1373855..1375516) VII 1 NT_166526.1 Similarity: shows similarity to different dehydrogenases.; Title: strong similarity to alcohol dehydrogenase alkJ - Pseudomonas oleovorans; See PMID 1542121; uncharacterized protein 1375516 4984789 An11g05600 Aspergillus niger uncharacterized protein XP_001394546.1 1373855 R 5061 CDS An11g05610 84592300 join(1375924..1376037,1376097..1376324,1376413..1376580) VII 1 NT_166526.1 hypothetical protein 1376580 84592300 An11g05610 Aspergillus niger hypothetical protein XP_059601611.1 1375924 D 5061 CDS An11g05620 84592301 complement(join(1376911..1376994,1377104..1377313,1377401..1377622,1378546..1378739,1378817..1378925,1379008..1379096,1379486..1379554,1379771..1379819,1379924..1380097,1380287..1380367)) VII 1 NT_166526.1 hypothetical protein 1380367 84592301 An11g05620 Aspergillus niger hypothetical protein XP_059601612.1 1376911 R 5061 CDS An11g05630 4984792 join(1380377..1380614,1380800..1381015,1381106..1382412) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein encoded by An11g09250 - Aspergillus niger; uncharacterized protein 1382412 4984792 An11g05630 Aspergillus niger uncharacterized protein XP_059601613.1 1380377 D 5061 CDS An11g05640 4984793 complement(join(1383222..1383466,1383529..1383821,1383876..1383974,1384038..1384201)) VII 1 NT_166526.1 Title: strong similarity to hypothetical methyltransferase SPAC2G11.15C - Schizosaccharomyces pombe; uncharacterized protein 1384201 4984793 An11g05640 Aspergillus niger uncharacterized protein XP_001394550.3 1383222 R 5061 CDS An11g05650 4984794 join(1384339..1384488,1384577..1384660,1384714..1385496) VII 1 NT_166526.1 Function: mammalian GRASP65 appears to function in the postmitotic reassembly of Golgi stacks.; Function: the mammalian peripheral golgi protein GRASP65 is a target of mitotic polo-like kinase (Plk) and cdc2.; Golgi; Title: similarity to golgi peripheral membrane protein p65 GRASP65 - Rattus norvegicus; See PMID 9346242; uncharacterized protein 1385496 4984794 An11g05650 Aspergillus niger uncharacterized protein XP_059601614.1 1384339 D 5061 CDS An11g05660 4984795 complement(1386850..1390614) VII 1 NT_166526.1 Title: similarity to erythrocyte splice form 1 of ankyrin ANK1 - Homo sapiens; uncharacterized protein 1390614 4984795 An11g05660 Aspergillus niger uncharacterized protein XP_001394552.3 1386850 R 5061 CDS An11g05670 84592302 join(1391124..1391263,1391350..1391401) VII 1 NT_166526.1 hypothetical protein 1391401 84592302 An11g05670 Aspergillus niger hypothetical protein XP_059601615.1 1391124 D 5061 CDS An11g05680 4984797 join(1391810..1392132,1392189..1393038,1393087..1393533) VII 1 NT_166526.1 Function: cytochrome P450s are involved in the oxidative degradation of various compounds. Particularly well known for their role in the degradation of environmental toxins and mutagens.; Title: similarity to cytochrome P450 3A13 - Mus musculus; uncharacterized protein 1393533 4984797 An11g05680 Aspergillus niger uncharacterized protein XP_001394554.1 1391810 D 5061 CDS An11g05690 84592303 complement(join(1393591..1393612,1393762..1393853,1393974..1394045,1394130..1394192,1394234..1394374)) VII 1 NT_166526.1 Similarity: shows similarity to several alpha subunit of dinitrogenase reductases of unidentified nitrogen-fixing bacteria.; Title: similarity to hypothetical alpha subunit of dinitrogenase reductase nifH - Unclassified organism; uncharacterized protein 1394374 84592303 An11g05690 Aspergillus niger uncharacterized protein XP_059601616.1 1393591 R 5061 CDS An11g05700 4984799 complement(join(1395120..1395758,1395824..1395916,1395979..1396005)) VII 1 NT_166526.1 Title: similarity to hypothetical membrane protein YGR235c - Saccharomyces cerevisiae; uncharacterized protein 1396005 4984799 An11g05700 Aspergillus niger uncharacterized protein XP_001394556.1 1395120 R 5061 CDS An11g05710 4984800 1396333..1398732 VII 1 NT_166526.1 Function: Oct1p of S. cerevisiae is part of mitochondrial protein import machinery component involved in the biogenesis of the oxidative phosphorylation system.; Title: strong similarity to mitochondrial intermediate peptidase Oct1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 10332043; uncharacterized protein 1398732 4984800 An11g05710 Aspergillus niger uncharacterized protein XP_001394557.1 1396333 D 5061 CDS An11g05720 84592304 join(1399562..1400638,1400730..1401038) VII 1 NT_166526.1 Remark: Blast similarities found to salivary proteins (mucine) from Drosophila melanogaster due to threonine stretches.; hypothetical protein 1401038 84592304 An11g05720 Aspergillus niger hypothetical protein XP_059601617.1 1399562 D 5061 CDS An11g05730 4984802 complement(1401279..1405133) VII 1 NT_166526.1 Title: strong similarity to polypeptide SEQ ID NO:40167 from patent WO200171042-A2 - Drosophila melanogaster; uncharacterized protein 1405133 4984802 An11g05730 Aspergillus niger uncharacterized protein XP_059601618.1 1401279 R 5061 CDS An11g05740 4984803 complement(join(1406188..1406323,1406606..1408957,1409075..1409241)) VII 1 NT_166526.1 Remark: similarity partially corresponds to serine repeats.; Title: weak similarity to hypothetical translation initiation factor SPAC17C9.03 - Schizosaccharomyces pombe; uncharacterized protein 1409241 4984803 An11g05740 Aspergillus niger uncharacterized protein XP_001394560.3 1406188 R 5061 CDS An11g05750 4984804 join(1409328..1409959,1410006..1410357,1410408..1410824) VII 1 NT_166526.1 Function: the phosphotyrosyl phosphatase activator Rrd1p of S. cerevisiae functions with Cla4p to regulate the G(2)/M transition.; Title: similarity to phosphotyrosyl phosphatase activator Rrd1 - Saccharomyces cerevisiae; See PMID 10660069; See PMID 11134337; uncharacterized protein 1410824 4984804 An11g05750 Aspergillus niger uncharacterized protein XP_001394561.1 1409328 D 5061 CDS An11g05760 4984805 complement(1411012..1412067) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein SPBC18H10.10c - Schizosaccharomyces pombe; uncharacterized protein 1412067 4984805 An11g05760 Aspergillus niger uncharacterized protein XP_001394562.3 1411012 R 5061 CDS An11g05770 4984806 1413365..1416421 VII 1 NT_166526.1 hypothetical protein 1416421 4984806 An11g05770 Aspergillus niger hypothetical protein XP_059601619.1 1413365 D 5061 CDS An11g05780 4984807 complement(join(1416727..1416836,1416942..1417295,1417492..1417729)) VII 1 NT_166526.1 Remark: blastp matches are due to repetitive seuqences.; hypothetical protein 1417729 4984807 An11g05780 Aspergillus niger hypothetical protein XP_001394564.3 1416727 R 5061 CDS An11g05790 84592305 join(1418478..1418723,1418822..1418998,1419390..1419518,1419664..1419816) VII 1 NT_166526.1 hypothetical protein 1419816 84592305 An11g05790 Aspergillus niger hypothetical protein XP_059601620.1 1418478 D 5061 CDS An11g05800 4984809 join(1420017..1420694,1420762..1420936,1421039..1421334,1421411..1421767) VII 1 NT_166526.1 Title: similarity to gene expression regulator Pc34 from patent WO200257456-A2 - Unclassified organism; uncharacterized protein 1421767 4984809 An11g05800 Aspergillus niger uncharacterized protein XP_059601621.1 1420017 D 5061 CDS An11g05810 4984810 complement(1422223..1422633) VII 1 NT_166526.1 Function: 2,4'-dihydroxyacetophenone dioxygenase catalyzes the conversion of 2,4'-dihydroxyacetophenone + O2 <=> 4-hydroxybenzoate + formate.; Title: similarity to 2,4-dihydroxyacetophenone dioxygenase dad - Alcaligenes sp.; See PMID 10567221; uncharacterized protein 1422633 4984810 An11g05810 Aspergillus niger uncharacterized protein XP_001394567.1 1422223 R 5061 CDS An11g05820 4984811 complement(join(1422841..1422947,1423063..1423466,1423553..1423752,1423808..1424212,1424287..1424433,1424489..1424535,1424647..1425045,1425206..1425269)) VII 1 NT_166526.1 Title: weak similarity to hypothetical transcription regulator, binuclear cluster zinc-finger protein SPBC1773.12 - Schizosaccharomyces pombe; uncharacterized protein 1425269 4984811 An11g05820 Aspergillus niger uncharacterized protein XP_059601622.1 1422841 R 5061 CDS An11g05840 4984812 complement(join(1425974..1426141,1426217..1426361,1426426..1426533,1426591..1426898)) VII 1 NT_166526.1 Similarity: shows similarity to several probable short chain dehydrogenase proteins of different species.; Title: strong similarity to hypothetical short chain dehydrogenase L3377.10 - Leishmania major; uncharacterized protein 1426898 4984812 An11g05840 Aspergillus niger uncharacterized protein XP_059601623.1 1425974 R 5061 CDS An11g05850 4984813 join(1427395..1427782,1427856..1428424,1428463..1428681,1428742..1428960,1429013..1429108) VII 1 NT_166526.1 Similarity: shows similarity to several oxidases.; Title: similarity to 6-hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans; uncharacterized protein 1429108 4984813 An11g05850 Aspergillus niger uncharacterized protein XP_059601624.1 1427395 D 5061 CDS An11g05860 84592306 complement(join(1429554..1430490,1430613..1431139,1431312..1431461,1431509..1431565)) VII 1 NT_166526.1 Remark: chi1 from E. dispar belongs to class 2 chitinases.; Similarity: shows similarity around the chitinase motif to several chitinases.; Title: similarity to chitinase cht1 - Entamoeba dispar; See PMID 9106188; uncharacterized protein 1431565 84592306 An11g05860 Aspergillus niger uncharacterized protein XP_059601625.1 1429554 R 5061 CDS An11g05870 10098083 complement(join(1432056..1433133,1433284..1433414,1433503..1433523,1433697..1433902,1434666..1434681,1434793..1434914,1435097..1435140,1435597..1436540)) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein encoded by An04g04580 - Aspergillus niger; uncharacterized protein 1436540 10098083 An11g05870 Aspergillus niger uncharacterized protein XP_003188844.2 1432056 R 5061 CDS An11g05880 84592307 1438041..>1438404 VII 1 NT_166526.1 Remark: C-terminally truncated due to contig end.; Title: strong similarity to hypothetical protein encoded by An12g03050 - Aspergillus niger [truncated ORF]; uncharacterized protein 1438404 84592307 An11g05880 Aspergillus niger uncharacterized protein XP_059601626.1 1438041 D 5061 CDS An11g05890 84592308 join(1439647..1440214,1440283..1440521,1440680..1440802) VII 1 NT_166526.1 hypothetical protein 1440802 84592308 An11g05890 Aspergillus niger hypothetical protein XP_059601627.1 1439647 D 5061 CDS An11g05900 4984818 complement(join(1441119..1441763,1441832..1442003,1442044..1442374,1442676..1442820)) VII 1 NT_166526.1 Remark: patent WO9831800-A2.; Title: weak similarity to BEF from patent WO9831800-A2 - Homo sapiens; uncharacterized protein 1442820 4984818 An11g05900 Aspergillus niger uncharacterized protein XP_059601628.1 1441119 R 5061 CDS An11g05910 4984819 1443265..1444296 VII 1 NT_166526.1 Remark: LovC interacts with LNKS and is necessary for the correct processing of the growing polyketide chain and production of dihydromonacolin L.; Remark: putative part of the lovastatin biosynthesis gene cluster as seen in Aspergillus terreus.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994; uncharacterized protein 1444296 4984819 An11g05910 Aspergillus niger uncharacterized protein XP_001394576.1 1443265 D 5061 CDS An11g05920 4984820 complement(1444696..1446045) VII 1 NT_166526.1 Catalytic activity: hydrolysis of Xaa-|-Pro dipeptides; also acts on aminoacyl- hydroxyproline analogs. No action on Pro-|-Pro.; Remark: homology was seen with the yeast hypothetical protein YJL213w.; Title: strong similarity to prolidase -Aureobacterium esteraromaticum; See PMID 9989239; uncharacterized protein 1446045 4984820 An11g05920 Aspergillus niger uncharacterized protein XP_001394577.3 1444696 R 5061 CDS An11g05930 4984821 join(1447547..1447704,1447801..1447881,1448106..1448270,1448338..1448695,1448747..1448986,1449040..1449390) VII 1 NT_166526.1 Remark: DAL5 encodes a component of the allantoate transport system.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 10943556; See PMID 3275614; uncharacterized protein 1449390 4984821 An11g05930 Aspergillus niger uncharacterized protein XP_059601629.1 1447547 D 5061 CDS An11g05940 4984822 complement(join(1450299..1450969,1451024..1451195,1451246..1451832,1451888..1456754,1456801..1457142,1457193..1457461,1457511..1457850)) VII 1 NT_166526.1 Catalytic activity: 6 Malonyl-CoA + Propanoyl-CoA = 7 CoA + 6-Deoxyerythronolide b.; Remark: PKS1 is a multifunctional polyketide synthase (PKS) with six catalytic domains arranged in the following order, starting at the N terminus: beta-ketoacyl synthase, acyltransferase, dehydratase, enoyl reductase,beta-ketoacyl reductase, and acyl carrier protein.; Remark: PKS1 is involved in production of the virulence factor T-toxin.; Remark: putative part of the lovastatin biosynthesis gene cluster as seen in Aspergillus terreus.; Similarity: shows also strong similarity to lovF Aspergillus terreus.; Title: strong similarity to polyketide synthase PKS1 - Cochliobolus heterostrophus; See PMID 10334994; See PMID 8953776; uncharacterized protein 1457850 4984822 An11g05940 Aspergillus niger uncharacterized protein XP_001394579.1 1450299 R 5061 CDS An11g05950 4984823 join(1458602..1459395,1459674..1460091) VII 1 NT_166526.1 Remark: putative part of the lovastatin biosynthesis gene cluster as seen in Aspergillus terreus.; Remark: the protein shows similarity to one unknown protein of the Aspergillus terreus lovastatin biosynthesis gene cluster but seems to long.; Remark: the similarity to the dfr1 is only in the N-terminal part of the protein.; Title: weak similarity to dihydrofolate reductase dfr1p - Schizosaccharomyces pombe; See PMID 10334994; See PMID 8088538; uncharacterized protein 1460091 4984823 An11g05950 Aspergillus niger uncharacterized protein XP_059601630.1 1458602 D 5061 CDS An11g05960 4984824 join(1462231..1462401,1462462..1462606,1462674..1462942,1463025..1463381,1463442..1463844,1463992..1464405,1464462..1465612,1465672..1465960,1465991..1470345) VII 1 NT_166526.1 Remark: putative part of the lovastatin biosynthesis gene cluster as seen in Aspergillus terreus.; Remark: the lovF gene encodes an enzyme that is responsible for the biosynthesis of the (2R)-2-methylbutyryl side chain of lovastatin.; Title: strong similarity to lovastatin diketide synthase lovF - Aspergillus terreus; See PMID 10334994; uncharacterized protein 1470345 4984824 An11g05960 Aspergillus niger uncharacterized protein XP_059601631.1 1462231 D 5061 CDS An11g05970 4984825 complement(join(1471271..1471734,1471809..1471964,1472017..1472186,1472244..1472481,1472696..1472819)) VII 1 NT_166526.1 Remark: the protein shows similarity only with the C-terminal region of lysozyme2.; Title: weak similarity to muramidase-2 -Enterococcus hirae; See PMID 1347040; uncharacterized protein 1472819 4984825 An11g05970 Aspergillus niger uncharacterized protein XP_059601632.1 1471271 R 5061 CDS An11g05980 4984826 complement(join(1473108..1473164,1473240..1474550)) VII 1 NT_166526.1 Remark: also similarity to ankyrin PBmAnk302 patent US5824306-A.; Title: weak similarity to protein encoded by clone CTONG20183430 from patent EP1308459-A2 - Homo sapiens; uncharacterized protein 1474550 4984826 An11g05980 Aspergillus niger uncharacterized protein XP_001394583.1 1473108 R 5061 CDS An11g05990 4984827 join(1475917..1476018,1476069..1476548) VII 1 NT_166526.1 hypothetical protein 1476548 4984827 An11g05990 Aspergillus niger hypothetical protein XP_001394584.1 1475917 D 5061 CDS An11g06000 4984828 complement(join(1477900..1478262,1478321..1478669,1478745..1478846,1479041..1479261)) VII 1 NT_166526.1 Remark: SRPK1 specifically induces the disassembly of nuclear speckles, and a high level of SRPK1 inhibits splicing in vitro.; Remark: the sequenz shows also similarity to the Human protein kinase hYAK3-alpha patent EP870825-A1.; Remark: the serine protein kinase SRPK1 from human is aproximately 250 aa longer.; Title: similarity to serine protein kinase SRPK1 -Homo sapiens; See PMID 8208298; uncharacterized protein 1479261 4984828 An11g06000 Aspergillus niger uncharacterized protein XP_059601633.1 1477900 R 5061 CDS An11g06010 84592309 1480049..1480381 VII 1 NT_166526.1 hypothetical protein 1480381 84592309 An11g06010 Aspergillus niger hypothetical protein XP_059601634.1 1480049 D 5061 CDS An11g06030 84592310 complement(join(1481524..1481833,1481906..1482351)) VII 1 NT_166526.1 Remark: the protein shows also similarity to ankyrin like proteins in the N-terminal part.; Title: weak similarity to protein CGDD-16 from patent WO2002102310-A2 - Homo sapiens; uncharacterized protein 1482351 84592310 An11g06030 Aspergillus niger uncharacterized protein XP_059601635.1 1481524 R 5061 CDS An11g06040 4984832 join(1483742..1483786,1483913..1484178,1484286..1484289,1484764..1484799,1484866..1484989,1485235..1486412) VII 1 NT_166526.1 Catalytic activity: ATP + Choline = ADP + Choline phosphate.; Pathway: glycerolipid metabolism.; Remark: choline kinase catalyses the committed step in the synthesis of phosphatidylcholine by the CDP-choline pathway.; Remark: the sequence shows similarity to a wide range of choline kinases in different organisms.; Title: similarity to choline kinase CK1 - Glycine max; See PMID 8934624; uncharacterized protein 1486412 4984832 An11g06040 Aspergillus niger uncharacterized protein XP_001394588.3 1483742 D 5061 CDS An11g06050 84592311 complement(join(1487004..1487006,1487054..1487260,1487327..1487497)) VII 1 NT_166526.1 hypothetical protein 1487497 84592311 An11g06050 Aspergillus niger hypothetical protein XP_059601636.1 1487004 R 5061 CDS An11g06060 4984834 complement(join(1488122..1492139,1492197..1492556,1492669..1493146,1493377..1493550,1493600..1493767,1493824..1494553)) VII 1 NT_166526.1 Remark: ankyrin participates in signal transduction and in assembly of integral membrane proteins.; Remark: ankyrins are linker proteins, which connect various membrane proteins, including members of the L1 family of neural cell adhesion molecules, with the submembranous actin-spectrin skeleton.; Remark: expression of Dank2 is restricted to the nervous system in the Drosophila embryo.; Title: strong similarity to ankyrin 2 Ank2 -Drosophila melanogaster; See PMID 10844021; See PMID 11018513; uncharacterized protein 1494553 4984834 An11g06060 Aspergillus niger uncharacterized protein XP_059601637.1 1488122 R 5061 CDS An11g06070 4984835 1495540..1495851 VII 1 NT_166526.1 hypothetical protein 1495851 4984835 An11g06070 Aspergillus niger hypothetical protein XP_001394591.1 1495540 D 5061 CDS An11g06080 84592312 complement(join(1496621..1496774,1496841..>1498090)) VII 1 NT_166526.1 Catalytic activity: beta-glucosidases hydrolyse terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose.; Title: strong similarity to beta-glucosidase 1 bgl1 - Aspergillus aculeatus [truncated ORF]; extracellular/secretion proteins; See PMID 9757570; See PMID 8964516; uncharacterized protein 1498090 84592312 An11g06080 Aspergillus niger uncharacterized protein XP_059601638.1 1496621 R 5061 CDS An11g06090 4984836 complement(join(<1498191..1498267,1498320..>1499078)) VII 1 NT_166526.1 Catalytic activity: Hydrolysis of terminal,non-reducing beta-D-glucose residues with release of beta-D-glucose.; Title: strong similarity to beta-glucosidase2 BGL2 -Saccharomycopsis fibuligera; See PMID 3146949; uncharacterized protein 1499078 4984836 An11g06090 Aspergillus niger uncharacterized protein XP_001394592.3 1498191 R 5061 CDS An11g06100 4984838 complement(join(1499514..1499666,1499865..1499927,1500007..1500388,1500444..1501158,1501197..1501260)) VII 1 NT_166526.1 Similarity: the ORF encoded protein shows also in a distinct regionweak similarity to putative serine /threonin protein kinase Ca20C1. 20 from Candida albicans.; Title: similarity to hypothetical protein encoded by An15g02090 - Aspergillus niger; uncharacterized protein 1501260 4984838 An11g06100 Aspergillus niger uncharacterized protein XP_059606322.1 1499514 R 5061 CDS An11g06110 4984839 complement(join(1501606..1502003,1502059..1502568,1502641..1502668)) VII 1 NT_166526.1 Catalytic activity: Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.; Title: similarity to purine-nucleoside phosphorylase punA - Bacillus stearothermophilus; See PMID 9058965; uncharacterized protein 1502668 4984839 An11g06110 Aspergillus niger uncharacterized protein XP_001394595.1 1501606 R 5061 CDS An11g06120 4984840 complement(join(1503182..1504721,1504760..1504770)) VII 1 NT_166526.1 Catalytic activity: 6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH.; Title: strong similarity to decarboxylating phosphogluconate dehydrogenase - Medicago sativa; See PMID 7640360; uncharacterized protein 1504770 4984840 An11g06120 Aspergillus niger uncharacterized protein XP_001394596.3 1503182 R 5061 CDS An11g06130 4984841 1505266..1506315 VII 1 NT_166526.1 Title: strong similarity to hypothetical 3-dehydroshikimate dehydratase qa-4 - Neurospora crassa; uncharacterized protein 1506315 4984841 An11g06130 Aspergillus niger uncharacterized protein XP_001394597.1 1505266 D 5061 CDS An11g06140 4984842 complement(join(1506543..1507671,1507725..1508086,1508144..1508251,1508304..1508441)) VII 1 NT_166526.1 Catalytic activity: 1-pyrroline-5-carboxylate + Nad(+) + H(2)O = l-glutamate + NadH.; Function: p5cdh of H. sapiens catalyzes the irreversible conversion of delta-1-pyrroline-5-carboxylate (p5c), derived either from proline or ornithine, to glutamate which is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles.; Pathway: second step in the conversion of proline to glutamate.; Remark: the preferred substrate of p5cdh is glutamic gamma-semialdehyde, other substrates include succinic,glutaric and adipic semialdehydes.; Title: strong similarity to delta-1-pyrroline-5-carboxylate dehydrogenase p5cdh - Homo sapiens; localisation:mitochondrion; See PMID 8621661; uncharacterized protein 1508441 4984842 An11g06140 Aspergillus niger uncharacterized protein XP_001394598.1 1506543 R 5061 CDS An11g06150 4984843 complement(join(1509463..1509825,1509875..1510671,1510731..1510840,1510896..1510908,1510977..1511358)) VII 1 NT_166526.1 Remark: as ORF 70WG on the same contig encodes the A. niger prnA homolog, it is assumed, that the region consists of a proline utilisation gene cluster, important for the utilization of proline as sole nitrogen and/or carbon source.; Remark: prnB of A. nidulans encodes the major proline transport system and is part of a cluster of four genes necessary and sufficient for the utilization of proline as sole nitrogen and/or carbon source.; Title: strong similarity to proline permease prnB -Aspergillus nidulans; plasma membrane; See PMID 8437566; See PMID 9140969; See PMID 10613888; uncharacterized protein 1511358 4984843 An11g06150 Aspergillus niger uncharacterized protein XP_001394599.1 1509463 R 5061 CDS An11g06160 4984844 join(1513284..1513870,1513927..1514776) VII 1 NT_166526.1 Title: strong similarity to proline oxidase prnD -Aspergillus nidulans; localisation:mitochondrion; See PMID 355839; See PMID 9184237; uncharacterized protein 1514776 4984844 An11g06160 Aspergillus niger uncharacterized protein XP_001394600.1 1513284 D 5061 CDS An11g06170 4984845 1515364..1516410 VII 1 NT_166526.1 Alternative name: THBP; Function: Crym of H. sapiens binds thyroid hormone and is presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors.; Similarity: Crym of H. sapiens is similar to bacterial ornithine cyclodeaminases.; Title: similarity to thyroid hormone-binding protein mu-crystallin Crym - Homo sapiens; cytoplasm; See PMID 9328354; See PMID 1384048; uncharacterized protein 1516410 4984845 An11g06170 Aspergillus niger uncharacterized protein XP_001394601.1 1515364 D 5061 CDS An11g06180 4984846 join(1516933..1517021,1517119..1517253,1517332..1517603,1517669..1517754,1517806..1518440,1518491..1518661,1518709..1519726) VII 1 NT_166526.1 Function: the prnA gene of A. nidulans codes for a transcriptional activator that mediates proline induction of four other genes involved in proline utilization as a nitrogen and/or carbon source.; Title: strong similarity to transcription activator prnA - Aspergillus nidulans; nucleus; See PMID 622360; uncharacterized protein 1519726 4984846 An11g06180 Aspergillus niger uncharacterized protein XP_001394602.1 1516933 D 5061 CDS An11g06190 4984847 complement(join(1520005..1521132,1521200..1521451)) VII 1 NT_166526.1 Remark: Nucleolin induces chromatin decondensation by binding to histone h1 and is thought to play a role in pre-rrna transcription and ribosome assembly.; Remark: Nucleolin is the major nucleolar protein of growing eukaryotic cells and is found associated with intranucleolar chromatin and preribosomal particles.; Title: similarity to nucleolin protein C23 - Homo sapiens; nucleus; uncharacterized protein 1521451 4984847 An11g06190 Aspergillus niger uncharacterized protein XP_001394603.1 1520005 R 5061 CDS An11g06200 4984848 complement(join(1522071..1522121,1522178..1522827,1522897..1523038)) VII 1 NT_166526.1 Catalytic activity: NADH + ubiquinone = NAD(+) + ubiquinol.; Title: strong similarity to 31 kD subunit of NADH:ubiquinone reductase - Neurospora crassa; localisation:mitochondrion; See PMID 2145832; See PMID 2142943; uncharacterized protein 1523038 4984848 An11g06200 Aspergillus niger uncharacterized protein XP_001394604.3 1522071 R 5061 CDS An11g06210 10098249 join(1523626..1523678,1523759..1523825,1523930..1524045,1524124..1524492,1524554..1526193,1527412..1529663) VII 1 NT_166526.1 Alternative name: MOT2; Remark: S. cerevisiae Mot2 gene encodes a putative zinc finger protein that negatively regulates several categories of genes, including mating-pheromone-responsive genes.; Title: strong similarity to zinc-finger protein Sig1 - Saccharomyces cerevisiae; nucleus; See PMID 8039500; See PMID 8164669; See PMID 8164670; uncharacterized protein 1529663 10098249 An11g06210 Aspergillus niger uncharacterized protein XP_059606323.1 1523626 D 5061 CDS An11g06230 4984850 complement(1529892..1530965) VII 1 NT_166526.1 Remark: Patentmatch against protein AC AX065577_1 Tremblnew.; Title: similarity to oxidoreductase from patent WO0100844 - Corynebacterium glutamicum; uncharacterized protein 1530965 4984850 An11g06230 Aspergillus niger uncharacterized protein XP_001394606.1 1529892 R 5061 CDS An11g06240 84592313 complement(1532406..1534472) VII 1 NT_166526.1 Title: weak similarity to kinetochore protein CENP-F - Homo sapiens; See PMID 7542657; uncharacterized protein 1534472 84592313 An11g06240 Aspergillus niger uncharacterized protein XP_059606324.1 1532406 R 5061 CDS An11g06250 84592314 complement(join(1534761..1534953,1535134..1535289,1535467..1535556,1535686..1535748,1535838..1535892,1535999..1536079,1536175..1536230,1536275..1536372)) VII 1 NT_166526.1 Similarity: a short stretch of amino acids shows some similarity to a D. melanogaster hypothetical ORF; the structure of the gene model remains questionable.; Title: questionable ORF; uncharacterized protein 1536372 84592314 An11g06250 Aspergillus niger uncharacterized protein XP_059606325.1 1534761 R 5061 CDS An11g06260 4984853 complement(join(1537680..1537749,1537807..1538030,1538090..1538123,1538173..1538262,1538311..1538456,1538546..1538718,1538842..1539175)) VII 1 NT_166526.1 Function: pentalenene synthase of Streptomyces is a terpenoid cyclase; the similarity of the predicted ORF is to weak to allow any conclusion about its function.; Title: weak similarity to pentalenene synthase -Streptomyces sp.; See PMID 8180213; See PMID 9295272; uncharacterized protein 1539175 4984853 An11g06260 Aspergillus niger uncharacterized protein XP_059606326.1 1537680 R 5061 CDS An11g06270 4984854 join(1539903..1540739,1540804..1540918,1540974..1541266,1541327..1541782) VII 1 NT_166526.1 Catalytic activity: GfCPS/KS of G. fujikuroi converts geranylgeranyl diphosphate to copalyl diphosphate and ent-kaurene.; Pathway: terpenoid biosynthesis.; Similarity: the C-terminal part of GfCPS/KS of G. fujikuroi is not conserved in the predicted ORF.; Title: strong similarity to Ent-Kaurene synthase GfCPS/KS - Gibberella fujikuroi; See PMID 10644675; See PMID 10803977; uncharacterized protein 1541782 4984854 An11g06270 Aspergillus niger uncharacterized protein XP_001394610.3 1539903 D 5061 CDS An11g06280 4984855 complement(join(1542163..1542225,1542321..1542492,1542600..1543675)) VII 1 NT_166526.1 Remark: the patented entry is an amino acid sequence conceptually translated from a DNA sequence.; Title: strong similarity to protein fragment SEQ ID NO:17197 from patent EP1033405 - Arabidopsis thaliana; uncharacterized protein 1543675 4984855 An11g06280 Aspergillus niger uncharacterized protein XP_001394611.3 1542163 R 5061 CDS An11g06290 4984856 complement(join(1544862..1545002,1545095..1546155,1546236..1546948,1547167..1547308,1547462..1547480)) VII 1 NT_166526.1 Function: the transcriptional activator XlnR regulates both xylanolytic and endoglucanase gene expression in A. niger.; Remark: the existence of three closely-spaced ORFs (cmln. 00. tfa_160ck, 170wg, and 186wk) displaying strong similarity, but not identity, to three unrelated A. niger genes, suggests the presence of a duplication of a chromosomal region; an independent evolutionary process might have produced the observed difference between the predicted and the described proteins.; Title: strong similarity to transcription activator xlnR - Aspergillus niger; nucleus; See PMID 9466262; See PMID 9758775; See PMID 10376490; See PMID 10508057; See PMID 10760176; uncharacterized protein 1547480 4984856 An11g06290 Aspergillus niger uncharacterized protein XP_001394612.3 1544862 R 5061 CDS An11g06300 84592315 complement(join(1547782..1548163,1548230..1548326,1548400..1548477,1548551..1549114,1549234..1549771,1549825..1550024,1550091..1550381,1550464..1550656)) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein AAO76091.1 - Bacteroides thetaiotaomicron; uncharacterized protein 1550656 84592315 An11g06300 Aspergillus niger uncharacterized protein XP_059606327.1 1547782 R 5061 CDS An11g06310 84592316 complement(join(1552504..1552528,1552620..1552740,1552851..1553091)) VII 1 NT_166526.1 hypothetical protein 1553091 84592316 An11g06310 Aspergillus niger hypothetical protein XP_059606328.1 1552504 R 5061 CDS An11g06320 4984859 complement(join(1553784..1553931,1553991..1554082,1554139..1554159,1554225..1554338,1554395..1554688,1554755..1555080,1555140..1555165,1555219..1555324,1555397..1555495,1555555..1555660)) VII 1 NT_166526.1 Function: rhamnogalacturonases allow A. niger to use plant pectins as carbon source.; Remark: the existence of three closely-spaced ORFs (cmln. 00. tfa_160ck, 170wg, and 186wk) displaying strong similarity, but not identity, to three unrelated A. niger genes, suggests the presence of a duplication of a chromosomal region; an independent evolutionary process might have produced the observed difference between the predicted and the described proteins.; Similarity: the predicted ORF shows equally strong similarity to both rhgA and rhgB genes, encoding the two known isoforms of rhamnogalacturonase of A. niger.; Similarity: the size of the predicted ORF suggested to use rhgA for the annotation.; Title: strong similarity to rhamnogalacturonase rhgA - Aspergillus niger; See PMID 7576553; See PMID 9212401; uncharacterized protein 1555660 4984859 An11g06320 Aspergillus niger uncharacterized protein XP_001394615.3 1553784 R 5061 CDS An11g06330 4984860 join(1556557..1556631,1556699..1556831,1556886..1557477,1557537..1558035) VII 1 NT_166526.1 Remark: in A. niger three alpha-galactosidases has already been characterized and named aglA, aglB, and aglC.; Remark: the existence of three closely-spaced ORFs (cmln. 00. tfa_160ck, 170wg, and 186wk) displaying strong similarity, but not identity, to three unrelated A. niger genes, suggests the presence of a duplication of a chromosomal region; an independent evolutionary process might have produced the observed difference between the predicted and the described proteins.; Similarity: also P. simplicissimum produces at least three different alpha-galactosidases, which substrate specificities are different and well studied.; Similarity: the predicted ORF is also very similar,but not identical to alpha-galactosidase aglB of A. niger.; Title: strong similarity to alpha-galactosidase 1 agl1 - Penicillium simplicissimum; See PMID 9463945; See PMID 9756469; See PMID 10347026; uncharacterized protein 1558035 4984860 An11g06330 Aspergillus niger uncharacterized protein XP_001394616.1 1556557 D 5061 CDS An11g06350 84592317 complement(join(1560133..1560159,1560317..1560397,1560443..1560818,1560886..1561199,1561271..1561840)) VII 1 NT_166526.1 Catalytic activity: release of a C-terminal amino acid with a broad specificity.; Function: cpy1 of S. pombe digests preferentially peptides containing an aliphatic or hydrophobic residue in p1' position, as well as methionine, leucine or phenylalanine in p1 position of ester substrate.; Function: cpy1 of S. pombe is involved in degradation of small peptides.; Localization: cpy1 of S. pombe is found in lysosome-like vacuoles.; Remark: carboxypeptidase C of S. pombe is also called carboxypeptidase Y, and the gene has the alternative names cpy1 or SPAC19G12. 10c.; Similarity: cpy1 of S. pombe belongs to peptidase family S10; also known as the serine carboxypeptidase family.; Similarity: the N-terminal part of cpy1 of S. pombe is not conserved in the predicted ORF; due to the vicinity of a retrotransposable element, it is possible to hypothesize that a portion of the gene went destroied due to the transposition event.; Title: strong similarity to carboxypeptidase C cpy1p - Schizosaccharomyces pombe; See PMID 9209031; uncharacterized protein 1561840 84592317 An11g06350 Aspergillus niger uncharacterized protein XP_059606329.1 1560133 R 5061 CDS An11g06380 4984863 1562456..1566868 VII 1 NT_166526.1 Title: strong similarity to hypothetical retrotransposon Tto1 - Nicotiana tabacum; uncharacterized protein 1566868 4984863 An11g06380 Aspergillus niger uncharacterized protein XP_001394618.1 1562456 D 5061 CDS An11g06400 84592318 join(1568834..1568941,1569246..1569708,1569835..1570216,1570274..1570601) VII 1 NT_166526.1 Title: weak similarity to hypothetical protein encoded by An04g07900 - Aspergillus niger; uncharacterized protein 1570601 84592318 An11g06400 Aspergillus niger uncharacterized protein XP_059606330.1 1568834 D 5061 CDS An11g06410 84592319 complement(join(1571143..1571160,1571233..1571244,1571286..1571521,1571624..1571817,1571866..1572016,1572110..1572206)) VII 1 NT_166526.1 Remark: SED4 of S. cerevisiae is also known as YCR067C.; Title: weak similarity to ER membrane protein Sed4 -Saccharomyces cerevisiae; See PMID 11168590; See PMID 7593162; See PMID 7865879; See PMID 1327759; See PMID 9880808; uncharacterized protein 1572206 84592319 An11g06410 Aspergillus niger uncharacterized protein XP_059606331.1 1571143 R 5061 CDS An11g06420 4984866 complement(join(1572505..1573758,1573827..1574207)) VII 1 NT_166526.1 Function: multidrug transporters are membrane proteins which, by an unknown mechanism, recognize diverse toxic compounds and efflux them from cells.; Similarity: the predicted ORF shows strong similarity also to ORF10 (metabolite transport protein),patentnumber WO200037629, belonging to the lovastatin gene cluster of A. terreus; note that other ORFs with similarity to members of this cluster where found on contig cmln. 00 (and namely 70cg, 80wg and 90cg).; Similarity: the predicted ORF shows strong similarity to several hypothetical members of the multidrug efflux transporters belonging to the major facilitator superfamily of transport proteins.; Title: strong similarity to sequence 253 from patent WO0100804 - Corynebacterium glutamicum; See PMID 10334994; uncharacterized protein 1574207 4984866 An11g06420 Aspergillus niger uncharacterized protein XP_059606332.1 1572505 R 5061 CDS An11g06430 4984867 complement(join(1574925..1575737,1575826..1575882,1575944..1576201)) VII 1 NT_166526.1 Function: PTH11 of M. grisea is required for appressorium differentiation in response to inductive surface cues.; Function: as do most fungal plant pathogens, M. grisea differentiates an infection structure specialized for host penetration called the appressorium.; Phenotype: M. grisea cells null mutant for PTH11 are no more pathogenic.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 11391010; uncharacterized protein 1576201 4984867 An11g06430 Aspergillus niger uncharacterized protein XP_001394622.1 1574925 R 5061 CDS An11g06440 4984868 1576823..1577911 VII 1 NT_166526.1 Catalytic activity: lovC of A. terreus probably acts as an enoyl reductase.; Function: lovC of A. terreus interacts with lovB in the biosynthesis of the lovastatin precursor dihydromonacolin L.; Remark: in A. terreus the genes involved in lovastatin biosynthesis are clustered; the structure of this cluster in A. terreus is very similar to what observed for the predicted ORFs cmln. 00. tfa_70cg, 80wg and 90cg.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994; uncharacterized protein 1577911 4984868 An11g06440 Aspergillus niger uncharacterized protein XP_001394623.1 1576823 D 5061 CDS An11g06450 4984869 complement(join(1578724..1579065,1579162..1579317)) VII 1 NT_166526.1 Remark: in A. terreus the genes involved in lovastatin biosynthesis are clustered; the structure of this cluster in A. terreus is very similar to what is observed for the predicted ORF.; Similarity: EST EMBLEST:BE760262 covers part of the last exon and of the putative 3'-UTR of the predicted gene.; Similarity: the ORF encoded protein shows also strong similarity to EST EMBLEST Acc. N. : BE760262 from Aspergillus niger.; Title: strong similarity to hypothetical protein encoded by An02g08300 - Aspergillus niger; uncharacterized protein 1579317 4984869 An11g06450 Aspergillus niger uncharacterized protein XP_059606333.1 1578724 R 5061 CDS An11g06460 4984870 join(1580344..1581272,1581324..1581699,1581750..1582158,1582203..1582393,1582459..1584011,1584070..1587142,1587203..1592365) VII 1 NT_166526.1 Function: like fatty acids, polyketides are assembled by successive decarboxylative condensations of simple precursors.; Function: many polyketides are antibiotics.; Function: polyketide synthases catalyze the assembly of complex natural products from simple precursors such as propionyl-CoA and methylmalonyl-CoA in a biosynthetic process that closely parallels fatty acid biosynthesis.; Function: whereas the intermediates in fatty acid biosynthesis are fully reduced to generate unfunctionalized alkyl chains, the intermediates in polyketide biosynthesis may be only partially processed, giving rise to complex patterns of functional groups.; Remark: in A. terreus the genes involved in lovastatin biosynthesis are clustered; the structure of this cluster in A. terreus is very similar to what observed for the predicted ORFs cmln. 00. tfa_70cg, 80wg and 90cg.; Remark: polyketide synthases are commercially valuable enzyme.; Title: strong similarity to lovastatin nonaketide synthase lovB - Aspergillus terreus; See PMID 10334994; See PMID 10872449; uncharacterized protein 1592365 4984870 An11g06460 Aspergillus niger uncharacterized protein XP_059606334.1 1580344 D 5061 CDS An11g06480 4984872 complement(join(1593095..1593110,1593163..1594121)) VII 1 NT_166526.1 Title: weak similarity to antigenic protein f86.aa from patent WO9859071 - Borrelia burgdorferi; uncharacterized protein 1594121 4984872 An11g06480 Aspergillus niger uncharacterized protein XP_001394626.3 1593095 R 5061 CDS An11g06490 4984873 complement(join(1595197..1595980,1596041..1596708,1596764..1597096)) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein CAD70872.1 - Neurospora crassa; uncharacterized protein 1597096 4984873 An11g06490 Aspergillus niger uncharacterized protein XP_059606335.1 1595197 R 5061 CDS An11g06500 84592320 complement(join(1598172..1598425,1598525..1598637,1598767..1598861)) VII 1 NT_166526.1 hypothetical protein 1598861 84592320 An11g06500 Aspergillus niger hypothetical protein XP_059606336.1 1598172 R 5061 CDS An11g06510 4984875 join(1599494..1599656,1599722..1600129,1600181..1600245,1600308..1600527,1600578..1600624,1600684..1601024,1601095..1601242,1601357..1601509) VII 1 NT_166526.1 Catalytic activity: chnB of Acinetobacter catalyzes the reaction: cyclohexanone + NADPH + O2 = 6-hexanolide + NADP+ + H2O.; Function: chnB of Acinetobacter is the key enzyme in the cyclohexanone oxidation pathway.; Similarity: the predicted ORF shows strong similarity to many hypothetical and known monooxygenases.; Title: strong similarity to cyclohexanone monooxygenase chnB - Acinetobacter sp.; See PMID 2177829; See PMID 3338974; See PMID 10543838; uncharacterized protein 1601509 4984875 An11g06510 Aspergillus niger uncharacterized protein XP_001394629.3 1599494 D 5061 CDS An11g06520 4984876 complement(join(1601900..1602576,1602667..1602924,1603251..1603349,1603422..1603527)) VII 1 NT_166526.1 Similarity: the similarity to nucleolin and other proteins is due almost exclusively to these repetitive units.; Title: weak similarity to protein SEQ ID NO:141 from patent WO200025728-A2 - Plasmodium falciparum; uncharacterized protein 1603527 4984876 An11g06520 Aspergillus niger uncharacterized protein XP_059606337.1 1601900 R 5061 CDS An11g06530 84592321 join(1603631..1603636,1603743..1603916) VII 1 NT_166526.1 Similarity: the predicted ORF shows weak similarity to many env retroviral proteins; it might represent the remnant of a retrotransposition event.; Title: weak similarity to envelope glycoprotein env - Human immunodeficiency virus type 1; See PMID 10381169; uncharacterized protein 1603916 84592321 An11g06530 Aspergillus niger uncharacterized protein XP_059606338.1 1603631 D 5061 CDS An11g06540 4984878 join(1604785..1604972,1605090..1605170,1605225..1605451,1605506..1607805) VII 1 NT_166526.1 Gene-ID: mndA; Remark: these observations suggest that, besides the hypothetical existence of a gene duplication, the differences with the A. niger MndA could be explained also by sequencing errors in the published sequence.; Similarity: in the region where the differences to the A. niger MndA exist, the predicted ORF is nearly identical to the beta-mannosidase (manB) gene of the related species A. aculeatus.; Similarity: the current DNA sequence was verified also on contig caoc. 00, that has an overlap to this region; no difference exists between the present contig cmln. 00 and contig caoc. 00.; Similarity: the differences of the predicted ORF to A. niger MndA, in the N-terminal region, are due to single nucleotide mismatches causing frameshifts.; See PMID 11358516; beta-mannosidase mndA-Aspergillus niger 1607805 mndA 4984878 mndA Aspergillus niger beta-mannosidase mndA-Aspergillus niger XP_059606339.1 1604785 D 5061 CDS An11g06550 84592322 complement(1608084..1608539) VII 1 NT_166526.1 hypothetical protein 1608539 84592322 An11g06550 Aspergillus niger hypothetical protein XP_059606340.1 1608084 R 5061 CDS An11g06560 84592323 join(1609539..1609597,1609718..1609776,1609878..1609949,1610378..1610482,1610566..1610686,1610936..1611038) VII 1 NT_166526.1 Title: questionable ORF; uncharacterized protein 1611038 84592323 An11g06560 Aspergillus niger uncharacterized protein XP_059606341.1 1609539 D 5061 CDS An11g06570 4984881 join(1611470..1613765,1613856..1614251,1614329..1614445,1614502..1614602) VII 1 NT_166526.1 Function: co-expression of het-e and het-c lead to cell death.; Function: het-e1 of P. anserina is responsible for vegetative incompatibility.; Remark: het-e1 of P. anserina shows also two sequence motifs, a GTP-binding domain and a repeated region that shares similarity with that of the beta-transducin.; Remark: the reactivity of the HET-E protein depends on two functional elements, a GTP-binding domain and several WD40 repeats.; Title: strong similarity to beta transducin-like protein het-e1 - Podospora anserina; See PMID 10974123; See PMID 7557402; See PMID 9435787; See PMID 10875280; uncharacterized protein 1614602 4984881 An11g06570 Aspergillus niger uncharacterized protein XP_059606342.1 1611470 D 5061 CDS An11g06580 84592324 join(1615851..1615879,1615958..1616038,1616204..1616642,1616702..1616864,1616923..1617038) VII 1 NT_166526.1 Function: Clk2 of M. musculus is a protein kinase constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing.; Remark: Phosphorylated serine- and arginine-rich (SR) proteins are components of the spliceosomal complex,and have been implicated in the control of alternative splicing.; Similarity: the presence of a ribosomal protein pattern in the N-terminal part of the predicted ORF may suggest possible interactions with RNA.; Similarity: the similarity of the predicted ORF to Clk2 of M. musculus involves only the C-terminal half of the protein.; Title: similarity to cdc2/CDC28-like kinase 2 Clk2 -Mus musculus; deleted EC_number 2.7.1.37; See PMID 9307018; uncharacterized protein 1617038 84592324 An11g06580 Aspergillus niger uncharacterized protein XP_059606343.1 1615851 D 5061 CDS An11g06590 4984883 join(1617434..1617620,1617698..1618458) VII 1 NT_166526.1 Function: COQ5 of S. cerevisiae is a 2-methoxy-6-polyprenyl-1,4-benzoquinone methyltransferase,involved in the biosynthesis of ubiquinone.; Remark: COQ5 of S. cerevisiae is also known as YML110c, DBI56, or TCM7.; Title: strong similarity to methyltransferase Coq5 -Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9083048; See PMID 9083049; See PMID 9873020; uncharacterized protein 1618458 4984883 An11g06590 Aspergillus niger uncharacterized protein XP_001394637.1 1617434 D 5061 CDS An11g06600 4984884 join(1619082..1619513,1619577..1620476) VII 1 NT_166526.1 Title: strong similarity to polysialic acid capsule expression protein kpsF - Escherichia coli; See PMID 9383150; uncharacterized protein 1620476 4984884 An11g06600 Aspergillus niger uncharacterized protein XP_001394638.1 1619082 D 5061 CDS An11g06610 4984885 complement(join(1621587..1621859,1621919..1622192,1622286..1622584)) VII 1 NT_166526.1 Catalytic activity: ATP + nicotinamide ribonucleotide <=> diphosphate + NAD(+).; Pathway: the human nicotinamide mononucleotide adenylyl transferase NMNAT is involved in the nicotinate and nicotinamide metabolism.; Similarity: the ORF encoded protein also shows strong similarity to the essential E. nidulans protein AN85 from patent WO9924580-A2, which is not precisely enough decribed.; Title: strong similarity to nicotinamide mononucleotide adenylyl transferase NMNAT - Homo sapiens; nucleus; See PMID 11248244; uncharacterized protein 1622584 4984885 An11g06610 Aspergillus niger uncharacterized protein XP_001394639.1 1621587 R 5061 CDS An11g06620 84592325 join(1623722..1623809,1623893..1623994,1624086..1624172,1624328..1624369,1624455..1624513) VII 1 NT_166526.1 hypothetical protein 1624513 84592325 An11g06620 Aspergillus niger hypothetical protein XP_059606344.1 1623722 D 5061 CDS An11g06630 4984887 join(1625370..1625656,1625712..1625806,1625902..1626545,1626617..1628222,1628273..1630553,1630590..1630723,1630779..1630928,1630980..1631176) VII 1 NT_166526.1 Catalytic activity: ATP + ubiquitin + protein lysine <=> AMP + diphosphate + protein N-ubiquityllysine.; Remark: S. cerevisiae Ufd4p directly interacts with the 26S proteasome.; Remark: alternate name for S. cerevisiae Ufd4: YKL010C.; Title: strong similarity to ubiquitin protein ligase Ufd4 - Saccharomyces cerevisiae; See PMID 7615550; See PMID 10688918; uncharacterized protein 1631176 4984887 An11g06630 Aspergillus niger uncharacterized protein XP_059606345.1 1625370 D 5061 CDS An11g06640 4984888 complement(join(1631498..1631518,1631706..1632488)) VII 1 NT_166526.1 Title: similarity to hypothetical protein SPBC26H8.11c - Schizosaccharomyces pombe; uncharacterized protein 1632488 4984888 An11g06640 Aspergillus niger uncharacterized protein XP_059606346.1 1631498 R 5061 CDS An11g06650 4984889 complement(join(1633439..1634293,1634342..1635553,1635604..1635837)) VII 1 NT_166526.1 Function: S. cerevisiae Rrp3 is required for pre-ribosomal RNA processing. It is involved in the maturation of the 35s-pre-rRNA and to its cleavage to mature 18s rRNA.; Remark: alternate name for S. cerevisiae Rrp3: YHR065C.; Similarity: the ORF encoded protein also shows strong similarity to the putative S. cerevisiae RNA helicase Mak5 and to the human ATP-dependent RNA helicase from patent US5888792-A, but their functions are not precisely enough decribed.; Title: strong similarity to ATP dependent RNA helicase Rrp3 - Saccharomyces cerevisiae; nucleus; See PMID 8774901; uncharacterized protein 1635837 4984889 An11g06650 Aspergillus niger uncharacterized protein XP_001394643.1 1633439 R 5061 CDS An11g06660 4984890 join(1636072..1636982,1637184..1637370) VII 1 NT_166526.1 Complex: coimmunoprecipitation experiments show that Spb1 is associated in vivo with the nucleolar proteins Nop1 and Nop5/58.; Function: Spb1p has been suggested to be a methyltransferase involved in rRNA formation. as AdoMet-dependent methyltransferases it is able to bind [(3)H]AdoMet in vitro.; Remark: alternate name for S. cerevisiae Spb1p: YCL054W.; Remark: if the spb1-2 mutant S. cerevisiae strain has been grown at the restrictive temperature, the processing of the 27S pre-rRNA into mature 25S rRNA and 5. 8S is completely abolished and production of mature 18S is reduced, while the abnormal 23S species is accumulated. the mutant also shows a reduced 60S ribosomal subunit content.; Title: strong similarity to methyltransferase required for 60S ribosomal subunit biogenesis Spb1 -Saccharomyces cerevisiae; nucleus; See PMID 10556316; See PMID 10648622; uncharacterized protein 1637370 4984890 An11g06660 Aspergillus niger uncharacterized protein XP_059606347.1 1636072 D 5061 CDS An11g06670 4984891 complement(1637750..1640887) VII 1 NT_166526.1 Catalytic activity: H(2)S + 3 NADP(+) + 3 H(2)O <=> sulfite + 3 NADPH.; Cofactor: FMN,FAD.; Function: S. cerevisiae Met10 is a enzyme that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.; Pathway: Met10 catalyzes the fourth step in the sulfate assimilation pathway that leads to the biosynthesis of methionin and cysteine.; Remark: alternate name for S. cerevisiae Met10: YFR030W.; Title: strong similarity to alpha subunit of assimilatory sulfite reductase Met10 - Saccharomyces cerevisiae; See PMID 7928966; See PMID 9634827; uncharacterized protein 1640887 4984891 An11g06670 Aspergillus niger uncharacterized protein XP_001394645.1 1637750 R 5061 CDS An11g06680 4984892 join(1641308..1641346,1641479..1642144) VII 1 NT_166526.1 Complex: the TIP30 protein interacts with Tat and with an SRB-containing RNA polymerase II complex both in vivo and in vitro.; Function: the human TIP30 protein is a cofactor that specifically enhances human immunodeficiency virus-1 (HIV-1) Tat-activated transcription.; Similarity: TIP30 (also named CC3) is a member of the short-chain dehydrogenases/reductases (SDR) family.; Title: strong similarity to Tat-interacting protein TIP30 - Homo sapiens; nucleus; See PMID 10892349; See PMID 9482853; uncharacterized protein 1642144 4984892 An11g06680 Aspergillus niger uncharacterized protein XP_001394646.1 1641308 D 5061 CDS An11g06690 4984893 complement(join(1642383..1642403,1642452..1642880)) VII 1 NT_166526.1 Title: weak similarity to cytoplasmic protein encore enc - Drosophila melanogaster; uncharacterized protein 1642880 4984893 An11g06690 Aspergillus niger uncharacterized protein XP_001394647.3 1642383 R 5061 CDS An11g06700 84592326 join(1644162..1644191,1644292..1644355,1644436..1644656,1645099..1645254) VII 1 NT_166526.1 hypothetical protein 1645254 84592326 An11g06700 Aspergillus niger hypothetical protein XP_059606348.1 1644162 D 5061 CDS An11g06710 84592327 complement(join(1646183..1646372,1646404..1646459)) VII 1 NT_166526.1 hypothetical protein 1646459 84592327 An11g06710 Aspergillus niger hypothetical protein XP_059606349.1 1646183 R 5061 CDS An11g06720 4984896 complement(join(1648413..1648552,1648647..1649065,1649131..1649315,1649383..1649406)) VII 1 NT_166526.1 Function: the S. cerevisiae Pre9p protein is a subunit of the yeast proteasome. The proteasome is a multicatalytic proteinase complex which catalyzes the degradation of peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.; Remark: alternate gene names for S. cerevisiae Pre9: PRS5, Y13 or YGR135W.; Title: strong similarity to proteasome 20S subunit Pre9 - Saccharomyces cerevisiae; See PMID 9087403; See PMID 1898763; uncharacterized protein 1649406 4984896 An11g06720 Aspergillus niger uncharacterized protein XP_001394650.1 1648413 R 5061 CDS An11g06730 4984897 join(1649781..1649850,1649905..1651556) VII 1 NT_166526.1 Complex: CA150 was found to bind to the hyperphosphorylated CTD of the actively transcribing RNA polymerase II (Pol II).; Function: the human CA150 protein is a cellular cofactor of Tat-mediated transcriptional activation. It is involved in regulation of RNA polymerase II mediated transcriptional elongation.; Remark: the Tat protein is a strong transcriptional activator from the human immunodeficiency virus type 1 (HIV-1).; Title: similarity to transcription factor CA150 -Homo sapiens; nucleus; See PMID 10908677; See PMID 9315662; See PMID 10373521; uncharacterized protein 1651556 4984897 An11g06730 Aspergillus niger uncharacterized protein XP_001394651.1 1649781 D 5061 CDS An11g06740 4984898 complement(1651905..1652732) VII 1 NT_166526.1 Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: weak similarity to neurofilament subunit NF-180 - Petromyzon marinus; uncharacterized protein 1652732 4984898 An11g06740 Aspergillus niger uncharacterized protein XP_059606350.1 1651905 R 5061 CDS An11g06750 4984899 join(1653518..1653524,1653635..1654476,1654509..1656527) VII 1 NT_166526.1 Similarity: the similarities of the ORF encoded protein to proteins matching with an e-Val less than 3e-19 are mainly based on repetitive structures.; Title: similarity to hypothetical protein SPCC645.13 - Schizosaccharomyces pombe; uncharacterized protein 1656527 4984899 An11g06750 Aspergillus niger uncharacterized protein XP_059606351.1 1653518 D 5061 CDS An11g06760 4984900 complement(join(1657264..1657722,1657806..1658122,1658201..1658243)) VII 1 NT_166526.1 Complex: the U1 snRNP, cap-binding complex (CBC) and Luc7 are in one complex. Luc7 is required for coprecipitation of U1 snRNP with CBC.; Function: S. cerevisiae Luc7p is a component of yeast U1 snRNP and is essential for vegetative growth. the loss of Luc7p disrupts U1 snRNP-CBC interaction.; Remark: alternate name for S. cerevisiae Luc7: YDL087C.; Remark: the LUC7 gene was identified by a mutation that causes lethality in a yeast strain lacking the nuclear cap-binding complex (CBC).; Title: strong similarity to small nuclear ribonucleoprotein Luc7 - Saccharomyces cerevisiae; nucleus; See PMID 10500099; uncharacterized protein 1658243 4984900 An11g06760 Aspergillus niger uncharacterized protein XP_059606352.1 1657264 R 5061 CDS An11g06770 4984901 join(1658696..1659054,1659116..1659510,1659562..1660589) VII 1 NT_166526.1 Similarity: the ORF encoded protein shows strongest similarity to hypothetical protein YHR188c from S. cerevisiae.; Title: strong similarity to skin cell protein from patent WO9955865-A1 - Rattus sp.; uncharacterized protein 1660589 4984901 An11g06770 Aspergillus niger uncharacterized protein XP_001394655.1 1658696 D 5061 CDS An11g06780 4984902 complement(join(1660806..1660821,1660878..1661080,1661150..1661308)) VII 1 NT_166526.1 Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: weak similarity to variable surface lipoprotein VlpD - Mycoplasma hyorhinis; uncharacterized protein 1661308 4984902 An11g06780 Aspergillus niger uncharacterized protein XP_059606353.1 1660806 R 5061 CDS An11g06790 4984903 complement(join(1662134..1662826,1662876..1663367)) VII 1 NT_166526.1 Similarity: the similarities of the ORF encoded protein to all matching proteins are mainly based on repetitive structures.; Title: weak similarity to DEAH-box RNA helicase Mut6 - Chlamydomonas reinhardtii; uncharacterized protein 1663367 4984903 An11g06790 Aspergillus niger uncharacterized protein XP_001394657.1 1662134 R 5061 CDS An11g06800 4984904 complement(join(1664329..1664384,1664417..1664738,1664784..1664813,1664887..1665108,1665154..1665651)) VII 1 NT_166526.1 Function: the S. cerevisiae Kar5/Fig3 protein is required for nuclear fusion.; Remark: alternate names for S. cerevisiae Kar5: Fig3 or YMR065W.; Title: similarity to protein involved in nuclear fusion Kar5 - Saccharomyces cerevisiae; See PMID 9382856; See PMID 9456310; See PMID 10069807; uncharacterized protein 1665651 4984904 An11g06800 Aspergillus niger uncharacterized protein XP_059606354.1 1664329 R 5061 CDS An11g06810 4984905 join(1666607..1666880,1666952..1667065,1667108..1667502) VII 1 NT_166526.1 Remark: alternate name for S. cerevisiae MRPL6: YHR147C,YML6 or 60S ribosomal protein L6(mitochondrial).; Similarity: the S. cerevisiae MRPL6 protein belongs to the L6p family of ribosomal proteins.; Title: strong similarity to mitochondrial ribosomal protein of the large subunit L6 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8358820; mitochondrial 54S ribosomal protein uL6m 1667502 4984905 An11g06810 Aspergillus niger mitochondrial 54S ribosomal protein uL6m XP_059606355.1 1666607 D 5061 CDS An11g06820 4984906 complement(1667704..1668762) VII 1 NT_166526.1 Catalytic activity: adenosine 3',5'-bisphosphate + H(2)O <=> adenosine 5'-phosphate + phosphate.; Function: Met22 is a metabolic phosphatase which catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. This reaction is part of the sulfour metabolism.; Remark: alternate names for S. cerevisiae Met22 are Hal2, YOL064C or 3'(2'),5'-bisphosphate nucleotidase.; Similarity: the S. cerevisiae Met22 enzyme belongs to the family of sodium-sensitive phosphatase.; Title: strong similarity to salt tolerance protein Met22 - Saccharomyces cerevisiae; See PMID 8910555; See PMID 10656801; uncharacterized protein 1668762 4984906 An11g06820 Aspergillus niger uncharacterized protein XP_001394660.3 1667704 R 5061 CDS An11g06830 4984907 join(1669777..1669791,1669942..1670083,1670238..1671166) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein SPBC31F10.07 - Schizosaccharomyces pombe; uncharacterized protein 1671166 4984907 An11g06830 Aspergillus niger uncharacterized protein XP_059606356.1 1669777 D 5061 CDS An11g06840 84592328 join(1671684..1671712,1671809..1671835,1671881..1671887,1671923..1671952) VII 1 NT_166526.1 Title: questionable ORF; uncharacterized protein 1671952 84592328 An11g06840 Aspergillus niger uncharacterized protein XP_059606357.1 1671684 D 5061 CDS An11g06850 4984909 complement(join(1672555..1672580,1672622..1674497)) VII 1 NT_166526.1 Remark: CtHAL3 the C. tropicalis homolog gene of S. cerevisiae HAL3 partially complements the salt sensitivity of a S. cerevisiae hal3 mutant.; Similarity: the ORF encoded protein is also similar to the S. cerevisiae Hal3 (Sis2) protein: Pubmed 7565698.; Title: similarity to salt-tolerance protein HAL3 -Candida tropicalis; See PMID 8923737; uncharacterized protein 1674497 4984909 An11g06850 Aspergillus niger uncharacterized protein XP_059606358.1 1672555 R 5061 CDS An11g06860 4984910 complement(join(1675541..1676985,1677038..1677245)) VII 1 NT_166526.1 Title: strong similarity to multidrug transporter bmr3 - Bacillus subtilis; See PMID 9023234; uncharacterized protein 1677245 4984910 An11g06860 Aspergillus niger uncharacterized protein XP_001394664.1 1675541 R 5061 CDS An11g06870 84592329 join(1679092..1679098,1679167..1679271,1679333..1679509,1679570..1679586) VII 1 NT_166526.1 Similarity: the similarities of the ORF encoded protein to all matching proteins are based on repetitive structures.; Title: weak similarity to haploid specific alanine-rich acidic protein halap-X - Mus musculus; uncharacterized protein 1679586 84592329 An11g06870 Aspergillus niger uncharacterized protein XP_059606359.1 1679092 D 5061 CDS An11g06880 4984912 complement(join(1679947..1680318,1680401..1680917,1680989..1681014)) VII 1 NT_166526.1 Similarity: the similarities of the ORF encoded protein to all matching proteins are based on repetitive structures.; Title: weak similarity to h-caldesmon - Gallus gallus; uncharacterized protein 1681014 4984912 An11g06880 Aspergillus niger uncharacterized protein XP_001394666.1 1679947 R 5061 CDS An11g06890 4984913 join(1682062..1682112,1682252..1682412,1682480..1682789) VII 1 NT_166526.1 Title: weak similarity to PDZ domain protein MUPP1 -Rattus norvegicus; See PMID 9537516; uncharacterized protein 1682789 4984913 An11g06890 Aspergillus niger uncharacterized protein XP_001394667.1 1682062 D 5061 CDS An11g06900 4984914 complement(join(1683851..1683987,1684042..1684223,1684276..1684390,1684445..1684482,1684605..1684646,1684839..1684846,1684935..1684967)) VII 1 NT_166526.1 Function: S. cerevisiae UBC8 functions in catabolite degradation of fructose-1, 6-bisphosphatase.; Function: T. aestivum TaUBC4 is capable of binding ubiquitin by means of a thiol ester linkage in an ATP-dependent and ubiquitin-activating enzyme-dependent reaction.; Function: T. aestivum TaUBC4 specifically ubiquinates histones without the help of ubiquitin-protein ligases (E3s) and shows strong similarity to S. cerevisiae UBC8.; Title: strong similarity to ubiquitin conjugating enzyme TaUBC4 - Triticum aestivum; See PMID 2557633; See PMID 8155884; See PMID 10811607; uncharacterized protein 1684967 4984914 An11g06900 Aspergillus niger uncharacterized protein XP_059606360.1 1683851 R 5061 CDS An11g06910 84592330 join(1685106..1685160,1685208..1685300,1685419..1685494,1685637..1685737,1685840..1685994,1686108..1686185) VII 1 NT_166526.1 hypothetical protein 1686185 84592330 An11g06910 Aspergillus niger hypothetical protein XP_059606361.1 1685106 D 5061 CDS An11g06920 4984916 join(1686496..1686732,1686907..1687140,1687194..1687253) VII 1 NT_166526.1 Complex: S. cerevisiae Apg12 is conjugated to Apg5p.; Complex: S. cerevisiae Apg16p interacts with theApg12-Apg5p conjugate and mediates self-multimerization that leads to cross-linking of Apg5p molecules and formation of a stable protein complex.; Complex: conjugation of S. cerevisiae Apg12 to Apg5p requires Apg7 a ubiquitin-E1-like enzyme and Apg10, a specific ubiquitin-E2-like enzymes.; Function: S. cerevisiae Apg12 is a polypeptide that is used as tag to affect the function of Apg5.; Function: S. cerevisiae Apg12 was isolated in a screen for autophagy-defective (apg) mutants, a process for the bulk degradation of proteins, in which cytoplasmic components of the cell are enclosed by double-membrane structures known as autophagosomes for delivery to lysosomes or vacuoles for degradation.; Function: in mouse Apg12-Apg5 complex formation is essential for the involvement of Apg5 in elongation of the isolation membranes and for targeting of a mammalian Aut7/Apg8 homologue, LC3, to the isolation membranes.; Remark: the systematic name for S. cerevisiae Apg12 is YBR217w.; Title: strong similarity to autophagy modulator Agp12 - Saccharomyces cerevisiae; cytoplasm; See PMID 11100732; See PMID 11266458; See PMID 9759731; See PMID 10406794; See PMID 10608654; uncharacterized protein 1687253 4984916 An11g06920 Aspergillus niger uncharacterized protein XP_059606362.1 1686496 D 5061 CDS An11g06930 4984917 complement(join(1687562..1688182,1688243..1688671)) VII 1 NT_166526.1 Catalytic activity: A. nidulans panB converts 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate to tetrahydrofolate + 2-dehydropantoate.; Function: A. nidulans panB is essential for the biosynthesis of coenzyme A, while the pathway intermediate 4'-phosphopantetheine is required for penicillin production.; Title: strong similarity to 3-methyl-2-oxobutanoate hydroxymethyltransferase panB - Aspergillus nidulans; See PMID 10503542; uncharacterized protein 1688671 4984917 An11g06930 Aspergillus niger uncharacterized protein XP_001394671.1 1687562 R 5061 CDS An11g06950 4984918 complement(join(1690614..1692173,1692315..1692830)) VII 1 NT_166526.1 Function: A. nidulans nimO is required for initiation of DNA synthesis and for efficient progression through S phase.; Function: nimO18 mutants abrogated a cell cycle checkpoint linking S and M phases by segregating their unreplicated chromatin. this checkpoint defect did not interfere with other checkpoints monitoring spindle assembly and DNA damage (dimer lesions), but did prevent activation of a DNA replication checkpoint.; Similarity: A. nidulans nimO is related structurally and functionally to S. cerevisiae Dbf4p, the regulatory subunit of Cdc7p kinase and contains a C-terminal PEST motif and a novel, short-looped Cys2-His2 zinc finger-like motif.; Title: strong similarity to DNA synthesis and mitotic checkpoint control protein nimO - Aspergillus nidulans; See PMID 10194410; uncharacterized protein 1692830 4984918 An11g06950 Aspergillus niger uncharacterized protein XP_059606363.1 1690614 R 5061 CDS An11g06960 4984919 complement(join(1693715..1693744,1693844..1693970,1694022..1694140,1694192..1694413,1694464..1694497,1694550..1694593,1694644..1695036,1695097..1695224,1695277..1695309,1695376..1695540,1695612..1695813)) VII 1 NT_166526.1 Complex: E. coli pepP forms a homotetramer.; Function: E. coli pepP is a proline specific aminopeptidase which releases any N-terminal amino acid that is linked to proline.; Remark: E. coli pepP is Zn2+ dependent.; Title: strong similarity to aminopeptidase II pepP -Escherichia coli; See PMID 2659585; uncharacterized protein 1695813 4984919 An11g06960 Aspergillus niger uncharacterized protein XP_001394673.1 1693715 R 5061 CDS An11g06970 4984920 join(1696397..1696460,1696519..1697255) VII 1 NT_166526.1 Title: similarity to hypothetical protein Ta1372 -Thermoplasma acidophilum; See PMID 11029001; uncharacterized protein 1697255 4984920 An11g06970 Aspergillus niger uncharacterized protein XP_001394674.1 1696397 D 5061 CDS An11g06980 4984921 join(1697834..1698164,1698399..1698844) VII 1 NT_166526.1 Function: human SIRT5 belongs to the Sir2-like proteins (sirtuins) and may metabolize NAD and have protein ADP-ribosyltransferase activity.; Function: yeast Sir2 protein regulates epigenetic gene silencing and as a possible antiaging effect it suppresses recombination of rDNA while cobB, a E. coli SIR2-like gene, seems to encode a pyridine nucleotide transferase.; Similarity: the predicted A. niger protein also shows similarity to lacR, the repressor of the lactose operon of S. aureus.; Title: similarity to sirtuin type 5 SIRT5 - Homo sapiens; See PMID 2163387; See PMID 10381378; uncharacterized protein 1698844 4984921 An11g06980 Aspergillus niger uncharacterized protein XP_059606364.1 1697834 D 5061 CDS An11g06990 4984922 join(1699686..1700341,1700621..1700905,1700984..1701979,1702316..1702694,1702743..1703143,1703267..1703282) VII 1 NT_166526.1 Function: S. pombe Rhp16 is involved in the nucleotide excision repair of UV damage.; Function: S. pombe rhp7 or rhp16 deficient cells are, in contrast to S. cerevisiae rad7 and rad16 mutants, only sensitive to UV irradiation if the alternative repair mechanism, UV damage repair (UVDR) is absent.; Induction: S. pombe Rhp16 is UV-inducible.; Similarity: S. pombe Rhp16 contains two Zn-finger motifs and a putative helicase domain.; Title: similarity to UV damage nucleotide excision repair protein rph16p - Schizosaccharomyces pombe; nucleus; See PMID 8879272; See PMID 10446227; uncharacterized protein 1703282 4984922 An11g06990 Aspergillus niger uncharacterized protein XP_059606365.1 1699686 D 5061 CDS An11g07000 4984923 complement(join(1703481..1703953,1704009..1704840)) VII 1 NT_166526.1 Function: S. fradiae aph phosphorylates, and thereby inactivates, the antibiotic neomycin.; Title: weak similarity to kanamycin kinase aph -Streptomyces fradiae; See PMID 2542127; See PMID 6310563; uncharacterized protein 1704840 4984923 An11g07000 Aspergillus niger uncharacterized protein XP_001394677.1 1703481 R 5061 CDS An11g07010 4984924 join(1705569..1706643,1706706..1707139) VII 1 NT_166526.1 Catalytic activity: C. tropicalis alk2 was shown to hydroxylate hexadecane, but had no hydroxylation activity towards lauric acid.; Induction: C. tropicalis alk2 is induced by growth on alkane.; Localization: C. tropicalis alk2 contains only one transmembrane domain and its N-terminus is located in the ER lumen.; Similarity: C. tropicalis alk2 belongs to the CYP52 family and an alternative name is CYP52A2.; Title: strong similarity to alkane-inducible cytochrome P450 alk2 - Candida tropicalis; endoplasmatic reticulum; See PMID 8375386; See PMID 1937041; uncharacterized protein 1707139 4984924 An11g07010 Aspergillus niger uncharacterized protein XP_001394678.1 1705569 D 5061 CDS An11g07020 4984925 complement(join(1708657..1709004,1709080..1709514)) VII 1 NT_166526.1 Similarity: the predicted A. niger protein shows strong similarity to several hyptothetical proteins derived from genome sequencing projects as well as to three A. niger ESTs, EMBLEST:BE759124, EMBLEST:BE759800 and EMBLEST:BE759798.; Title: similarity to hypothetical protein BAB52928.1 - Mesorhizobium loti; uncharacterized protein 1709514 4984925 An11g07020 Aspergillus niger uncharacterized protein XP_001394679.1 1708657 R 5061 CDS An11g07030 4984926 complement(join(1709923..1709994,1710181..1710449,1710525..1710607,1710665..1711146,1711216..1711383)) VII 1 NT_166526.1 Function: M. grisea pth11 mutants are nonpathogenic due to a defect in appressorium differentiation.; Function: it is suggested that M. grisea pth11p is not required for appressorium morphogenesis but is involved in host surface recognition.; Localization: a M. grisea Pth11-green fluorescent protein fusion localised to the cell membrane and vacuoles.; Pathway: in M. grisea exogenous activation of cellular signaling suppressed pth11 defects.; Similarity: similarity is from the predicted A. niger protein to the central region of M. grisea pth11,which is 300aa longer.; Title: similarity to plasma membrane protein Pth11 -Magnaporthe grisea; See PMID 10521529; uncharacterized protein 1711383 4984926 An11g07030 Aspergillus niger uncharacterized protein XP_001394680.3 1709923 R 5061 CDS An11g07040 4984927 complement(join(1712282..1712288,1712347..1712645)) VII 1 NT_166526.1 Similarity: the predicted A. niger protein shows strong similarity to 7 ESTs from A. niger, suggesting that it is a strongly expressed gene.; Title: strong similarity to EST an_2779 -Aspergillus niger; uncharacterized protein 1712645 4984927 An11g07040 Aspergillus niger uncharacterized protein XP_001394681.1 1712282 R 5061 CDS An11g07050 4984928 join(1713548..1713941,1714000..1714221,1714294..1714322,1714399..1714704) VII 1 NT_166526.1 Title: similarity to hypothetical protein CAD21295.1 - Neurospora crassa; uncharacterized protein 1714704 4984928 An11g07050 Aspergillus niger uncharacterized protein XP_001394682.1 1713548 D 5061 CDS An11g07060 4984929 complement(join(1714965..1715262,1715419..1715548,1715628..1716102)) VII 1 NT_166526.1 Title: weak similarity to actinomycin synthase III acmC - Streptomyces chrysomallus; See PMID 10780924; uncharacterized protein 1716102 4984929 An11g07060 Aspergillus niger uncharacterized protein XP_001394683.3 1714965 R 5061 CDS An11g07070 4984930 complement(1716654..1718060) VII 1 NT_166526.1 Complex: human SRPK2 bound unphosphorylated,cytoplasmic SF2/ASF but did not bind phosphorylated,nuclear SF2/ASF.; Function: human SRPK2 phosphorylates the Serine/arginine-rich (SR) family of splicing factors,mediating spliceosome assembly and the trafficking of splicing factors into the nucleus.; Title: similarity to SR protein-specific kinase SRPK2 - Homo sapiens; See PMID 9472028; See PMID 10196197; uncharacterized protein 1718060 4984930 An11g07070 Aspergillus niger uncharacterized protein XP_001394684.1 1716654 R 5061 CDS An11g07080 4984931 complement(join(1718504..1719447,1719497..1719630,1719688..1719844,1719892..1720267,1720327..1720709,1720783..1720855)) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein AAO78637.1 - Bacteroides thetaiotaomicron; uncharacterized protein 1720855 4984931 An11g07080 Aspergillus niger uncharacterized protein XP_001394685.1 1718504 R 5061 CDS An11g07090 4984932 complement(join(1721551..1721598,1721676..1722128,1722197..1722202)) VII 1 NT_166526.1 Title: weak similarity to bacteriocin 2 LbnB2 from patent WO9723619-A1 - Lactobacillus amylovorus; uncharacterized protein 1722202 4984932 An11g07090 Aspergillus niger uncharacterized protein XP_001394686.1 1721551 R 5061 CDS An11g07100 4984933 complement(join(1722489..1722519,1722729..1722814,1723205..1723762,1723823..1723867)) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein encoded by An01g05280 - Aspergillus niger; uncharacterized protein 1723867 4984933 An11g07100 Aspergillus niger uncharacterized protein XP_001394687.3 1722489 R 5061 CDS An11g07110 84592331 join(1724183..1724242,1724587..1724622,1724710..1724850) VII 1 NT_166526.1 Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1724850 84592331 An11g07110 Aspergillus niger uncharacterized protein XP_059606366.1 1724183 D 5061 CDS An11g07120 4984935 complement(1725933..1726823) VII 1 NT_166526.1 Function: the predicted A. niger protein shows weak similarity to several proteases with different specifities.; Title: strong similarity to glutamyl endoprotease polypeptide from patent WO200268623-A2 - Aspergillus niger; uncharacterized protein 1726823 4984935 An11g07120 Aspergillus niger uncharacterized protein XP_001394689.1 1725933 R 5061 CDS An11g07130 84592332 join(1727013..1727053,1727153..1727256,1727315..1727402,1727444..1727579) VII 1 NT_166526.1 hypothetical protein 1727579 84592332 An11g07130 Aspergillus niger hypothetical protein XP_059606367.1 1727013 D 5061 CDS An11g07140 84592333 join(1728979..1729187,1729433..1729672,1730128..1730255,1730341..1730669) VII 1 NT_166526.1 Similarity: the ORF encoded protein shows also weak similarity to hypothetical protein BAB11373. 1 from Arabidopsis thaliana.; Title: weak similarity to hypothetical protein encoded by An12g03730 - Aspergillus niger; uncharacterized protein 1730669 84592333 An11g07140 Aspergillus niger uncharacterized protein XP_059601639.1 1728979 D 5061 CDS An11g07150 4984938 complement(join(1731718..1731843,1732067..1732257,1732326..1732598,1732654..1732857,1732913..1732919,1732970..1733202,1733251..1733545,1733596..1735116)) VII 1 NT_166526.1 Function: AAA proteins act in a variety of cellular functions, including cell-cycle regulation, protein degradation, organelle biogenesis and vesicle-mediated protein transport.; Similarity: similarity is from the C-terminal region of the predicted A. niger protein to the central region of S. cerevisiae MSP1, which is 600 aa shorter.; Similarity: the predicted A. niger protein shows weak similarity to several AAA type ATPases.; Title: weak similarity to AAA family ATPase Msp1 -Saccharomyces cerevisiae; See PMID 8226973; See PMID 9695811; uncharacterized protein 1735116 4984938 An11g07150 Aspergillus niger uncharacterized protein XP_059601640.1 1731718 R 5061 CDS An11g07160 4984939 join(1735626..1735810,1735881..1736205,1736269..1736815,1736868..1736983,1737066..1737803) VII 1 NT_166526.1 Title: weak similarity to hypothetical protein encoded by An16g05640 - Aspergillus niger; uncharacterized protein 1737803 4984939 An11g07160 Aspergillus niger uncharacterized protein XP_059601641.1 1735626 D 5061 CDS An11g07170 84592334 complement(join(1738505..1738519,1738569..1738652,1738703..1738864)) VII 1 NT_166526.1 Function: it has been suggested that C. intestinalis CiGRP1 is a RNA-binding protein.; Localization: C. intestinalis CiGRP1 is found in all nuclei and in the cytoplasm.; Similarity: similarity is from the predicted A. niger protein to the glycine repeats of C. intestinalis CiGRP1, which is 80 aa longer.; Title: similarity to glycine rich putativly RNA-binding protein CiGRP1 - Ciona intestinalis; See PMID 10675629; uncharacterized protein 1738864 84592334 An11g07170 Aspergillus niger uncharacterized protein XP_059601642.1 1738505 R 5061 CDS An11g07180 84592335 join(1740197..1740473,1740530..1740640,1740702..1740995,1741066..1741322) VII 1 NT_166526.1 Title: weak similarity to Uncoupling protein 2 Ucp2 - Danio rerio; See PMID 10524261; uncharacterized protein 1741322 84592335 An11g07180 Aspergillus niger uncharacterized protein XP_059601643.1 1740197 D 5061 CDS An11g07190 4984942 complement(join(1742024..1742370,1742445..1742784,1742867..1742877,1742951..1743149,1743220..1743288)) VII 1 NT_166526.1 Catalytic activity: malate dehydrogenases convert (S)-malate + NAD(+) to oxaloacetate + NADH.; Function: malate dehydrogenases are involved in the tricarbolic-acid cycle of carbohydrate utilisation.; Title: strong similarity to mitochondrial malate dehydrogenase MDH - Mus musculus; localisation:mitochondrion; See PMID 3038184; uncharacterized protein 1743288 4984942 An11g07190 Aspergillus niger uncharacterized protein XP_001394696.1 1742024 R 5061 CDS An11g07200 84592336 complement(join(1743437..1743523,1743633..1743668)) VII 1 NT_166526.1 Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1743668 84592336 An11g07200 Aspergillus niger uncharacterized protein XP_059601644.1 1743437 R 5061 CDS An11g07210 4984944 complement(join(1743920..1746825,1746894..1746984)) VII 1 NT_166526.1 Complex: accumulation of ankyrin at cell contacts required the presence of the cytoplasmic domain of neuroglian activated by cell-cell contact.; Function: ankyrin links integral membrane proteins to the spectrin-based membrane skeleton.; Function: proteins containing ankyrin-repeats interact specifically with a diverse array of macromolecular targets and show an extraordinary variety of biological activities.; Similarity: similarity is from the C-terminal ankyrin-domain containing region of the predicted A. niger protein to the N-terminal half of D. melanogaster Ank.; Title: similarity to ankyrin Ank - Drosophila melanogaster; See PMID 10431175; See PMID 7937942; uncharacterized protein 1746984 4984944 An11g07210 Aspergillus niger uncharacterized protein XP_001394698.3 1743920 R 5061 CDS An11g07220 4984945 join(1747864..1747907,1747978..1748323,1748392..1748958) VII 1 NT_166526.1 Similarity: the ORF encoded protein shows also weak similarity to adult male testis cDNA 4930511N22 from Mus musculus.; Title: strong similarity to hypothetical protein EAA64855.1 - Aspergillus nidulans; uncharacterized protein 1748958 4984945 An11g07220 Aspergillus niger uncharacterized protein XP_059601645.1 1747864 D 5061 CDS An11g07250 84592337 1751638..1756050 VII 1 NT_166526.1 Title: strong similarity to reverse transcriptase pol - Volvox carteri; See PMID 7681411; uncharacterized protein 1756050 84592337 An11g07250 Aspergillus niger uncharacterized protein XP_059601646.1 1751638 D 5061 CDS An11g07270 4984947 complement(join(1757599..1758344,1758396..1758471,1758550..1758738)) VII 1 NT_166526.1 Catalytic activity: D(--)-mandelate dehydrogenase catalyses the NAD(+)-dependent oxidation of D-mandelate to phenylglyoxylate.; Title: strong similarity to D-mandelate dehydrogenase D-MDH - Rhodotorula graminis; See PMID 1731758; uncharacterized protein 1758738 4984947 An11g07270 Aspergillus niger uncharacterized protein XP_001394701.1 1757599 R 5061 CDS An11g07280 84592338 join(1758870..1759081,1759169..1759306,1759362..1759436,1759527..1759590,1759844..1759989,1760076..1760139) VII 1 NT_166526.1 Induction: in A. parasiticus expression of the hxtA gene, encoding a hexose transporter protein, was found to be concurrent with the aflatoxin pathway cluster genes, in aflatoxin-conducive medium.; Similarity: similarity is from the N-terminal region of the predicted A. niger protein to the C-terminal region of A. parasiticus hxtA, which is 300 aa longer.; Title: weak similarity to hexose transporter hxtA -Aspergillus parasiticus; See PMID 10978525; uncharacterized protein 1760139 84592338 An11g07280 Aspergillus niger uncharacterized protein XP_059601647.1 1758870 D 5061 CDS An11g07290 4984949 complement(1760256..1761023) VII 1 NT_166526.1 Catalytic activity: Streptomycin 3''-adenylyltransferases convert ATP + streptomycin to diphosphate + 3''-adenylylstreptomycin.; Function: S. aureus spc is a spectinomycin adenyltransferase that mediates resistance to spectinomycin but not to streptomycin and is part of Tn554, a IS-element.; Title: similarity to spectinomycin adenylyltransferase spc - Staphylococcus aureus; See PMID 2993813; uncharacterized protein 1761023 4984949 An11g07290 Aspergillus niger uncharacterized protein XP_001394703.1 1760256 R 5061 CDS An11g07300 4984950 join(1761620..1761638,1761745..1761821,1761881..1762287,1762353..1763093,1763109..>1763316) VII 1 NT_166526.1 Function: expression of C. albicans Flu1 mediated not only resistance to fluconazole but also to cycloheximide.; Remark: ORF 3'truncated due to end of contig.; Similarity: C. albicans Flu1 belongs to the major facilitator superfamily.; Title: similarity to fluconazole resistance protein FLU1 - Candida albicans [truncated ORF]; See PMID 11065353; uncharacterized protein 1763316 4984950 An11g07300 Aspergillus niger uncharacterized protein XP_059601648.1 1761620 D 5061 CDS An11g07310 4984951 complement(1763979..1769360) VII 1 NT_166526.1 Function: C. lagenarium PKS1 gene encodes a polyketide synthase involved in melanin biosynthesis.; Title: strong similarity to polyketide synthase PKS1 - Colletotrichum lagenarium; See PMID 7500937; uncharacterized protein 1769360 4984951 An11g07310 Aspergillus niger uncharacterized protein XP_001394705.1 1763979 R 5061 CDS An11g07320 4984952 join(1770000..1770209,1770261..1771004) VII 1 NT_166526.1 Catalytic activity: glyoxylases II convert (S)-(2-hydroxyacyl)glutathione + H(2)O to glutathione + a 2-hydroxy acid anion.; Function: S. cerevisiae GLO2 is involved in amino acid catabolism.; Remark: the systematic name for S. cerevisiae GLO2 is YDR272W.; Title: similarity to glyoxalase II Glo2 -Saccharomyces cerevisiae; cytoplasm; See PMID 9261170; uncharacterized protein 1771004 4984952 An11g07320 Aspergillus niger uncharacterized protein XP_001394706.1 1770000 D 5061 CDS An11g07330 4984953 complement(1771379..1772623) VII 1 NT_166526.1 Complex: P. fluorescens 6-HNAMO is a flavoprotein binding FAD and depending on NADH.; Function: P. fluorescens 6-HNAMO is used for the industrial production of 2,5-dihydroxypyridine.; Similarity: the predicted A. niger ORF is identical to the A. niger EST an_1529, EMBLEST:BE760351.; Title: similarity to 6-hydroxynicotinic acid mono-oxygenase 6-HNAMO from patent JP09121864-A -Pseudomonas fluorescens; See PMID 10091591; uncharacterized protein 1772623 4984953 An11g07330 Aspergillus niger uncharacterized protein XP_001394707.1 1771379 R 5061 CDS An11g07340 4984954 1773090..1773839 VII 1 NT_166526.1 Function: S. maritimus EncK is a putative O-methyl transferase implicated in enterocin polyketide biosynthesis.; Title: strong similarity to hypothetical O-methyl transferase EncK - Streptomyces maritimus; See PMID 11137817; uncharacterized protein 1773839 4984954 An11g07340 Aspergillus niger uncharacterized protein XP_001394708.1 1773090 D 5061 CDS An11g07350 4984955 complement(join(1774249..1775559,1775613..1776119,1776176..1776313,1776375..1776752)) VII 1 NT_166526.1 Function: GABA utilization is amdR-dependent in A. oryzae.; Title: similarity to transcription regulator amdR -Aspergillus oryzae; nucleus; See PMID 1452021; uncharacterized protein 1776752 4984955 An11g07350 Aspergillus niger uncharacterized protein XP_059601649.1 1774249 R 5061 CDS An11g07360 84592339 complement(join(1777191..1777304,1777391..1777651)) VII 1 NT_166526.1 hypothetical protein 1777651 84592339 An11g07360 Aspergillus niger hypothetical protein XP_059601650.1 1777191 R 5061 CDS An11g07370 84592340 complement(join(1777855..1777985,1778067..1778171,1778276..1778341,1778397..1778507,1778584..1778733,1778813..1778922,1779353..1779453,1779546..1779643,1779689..1779870,1779959..1779999)) VII 1 NT_166526.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1779999 84592340 An11g07370 Aspergillus niger uncharacterized protein XP_059601651.1 1777855 R 5061 CDS An11g07380 4984958 1780286..1781266 VII 1 NT_166526.1 Catalytic activity: P. fluorescens phzF catalyzes the hydroxylation of phenazine-1-carboxylic acid to 2-hydroxy-phenazine-1-carboxylic acid.; Function: P. fluorescens phzF is involved in the production of the broad-spectrum antibiotic phenazine-1-carboxylic acid (PCA).; Remark: the P. fluorescens PHZF gene is part of a seven gene cluster, containing phzABCDEFG.; Remark: the broad-spectrum antibiotic phenazine-1-carboxylic acid (PCA) is active against a variety of fungal root pathogens.; Title: similarity to phenazine biosynthesis oxidoreductase phzF - Pseudomonas fluorescens; See PMID 9573209; uncharacterized protein 1781266 4984958 An11g07380 Aspergillus niger uncharacterized protein XP_001394712.1 1780286 D 5061 CDS An11g07420 84592341 join(1783574..1783586,1783658..1783740,1783838..1783906,1783982..1784000,1784045..1784136,1784187..1784368,1784457..1784476,1784551..1784786) VII 1 NT_166526.1 Similarity: similarities correspond to multiple G-repeats.; hypothetical protein 1784786 84592341 An11g07420 Aspergillus niger hypothetical protein XP_059601652.1 1783574 D 5061 CDS An11g07430 84592342 complement(join(1784929..1784998,1785092..1785175,1785516..1785631)) VII 1 NT_166526.1 hypothetical protein 1785631 84592342 An11g07430 Aspergillus niger hypothetical protein XP_059601653.1 1784929 R 5061 CDS An11g07440 84592343 complement(join(1785712..1785799,1785942..1786005,1786104..1786225,1786359..1786416,1786529..1786600,1786646..1786715)) VII 1 NT_166526.1 Similarity: similarities correspond to multiple glutamine repeats.; hypothetical protein 1786715 84592343 An11g07440 Aspergillus niger hypothetical protein XP_059601654.1 1785712 R 5061 CDS An11g07450 4984965 join(1786816..1786858,1786930..1787038,1787284..1787488,1787544..1787699,1787752..1788206,1788261..1788290,1788342..1788840) VII 1 NT_166526.1 Function: the C. elegans PKC1B gene product catalyzes the formation of peptidyl-serine-phosphate or peptidyl-threonine-phosphate using ATP.; Remark: activity of the C. elegans protein kinase C is calcium-independent, phospholipid-dependent, and activated by diacylglycerol and by tumor-promoting phorbol esters; Title: similarity to neuronal protein kinase C PKC1B - Caenorhabditis elegans; See PMID 8132661; uncharacterized protein 1788840 4984965 An11g07450 Aspergillus niger uncharacterized protein XP_059601655.1 1786816 D 5061 CDS An11g07460 84592344 join(1788966..1789034,1789121..1789399) VII 1 NT_166526.1 hypothetical protein 1789399 84592344 An11g07460 Aspergillus niger hypothetical protein XP_059601656.1 1788966 D 5061 CDS An11g07480 84592345 join(1790740..1790841,1790919..1790975,1791059..1791133) VII 1 NT_166526.1 hypothetical protein 1791133 84592345 An11g07480 Aspergillus niger hypothetical protein XP_059601657.1 1790740 D 5061 CDS An11g07490 4984969 complement(join(1791375..1791451,1791537..1791597,1791654..1791694,1791769..1792924)) VII 1 NT_166526.1 Complex: S. cerevisiae Hoc1 forms the Golgi membrane mannosyltransferase A-complex with Anp1, Mnn9, Mnn10, and Mnn11.; Function: S. cerevisiae Hoc1 is an alpha-1,6-mannosyltransferase involved in protein mannosylation and O-glycosylation at the Golgi membrane.; Golgi; Title: similarity to alpha-1,6-mannosyltransferase Hoc1 - Saccharomyces cerevisiae; See PMID 10635561; See PMID 9055074; uncharacterized protein 1792924 4984969 An11g07490 Aspergillus niger uncharacterized protein XP_001394720.3 1791375 R 5061 CDS An11g07500 84592346 join(1794529..1794724,1794885..1795162) VII 1 NT_166526.1 hypothetical protein 1795162 84592346 An11g07500 Aspergillus niger hypothetical protein XP_059601658.1 1794529 D 5061 CDS An11g07510 4984971 join(1795577..1795639,1795700..1796562,1796779..1797268) VII 1 NT_166526.1 Catalytic activity: 6-Hydroxy-D-nicotine oxidases convert (R)-6-hydroxynicotine + H(2)O + O(2) to 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H(2)O(2).; Complex: A. oxidans 6-HDNO is covalently flavinylated.; Function: A. oxidans 6-HDNO is involved in nicotine catabolism.; Similarity: similarity is between the C-terminal regions of the predicted A. niger protein and A. oxidans 6-HDNO.; Title: similarity to 6-Hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 3622516; uncharacterized protein 1797268 4984971 An11g07510 Aspergillus niger uncharacterized protein XP_059601659.1 1795577 D 5061 CDS An11g07530 84592347 complement(join(1798104..1798271,1798404..1800341,1800387..1801597,1801846..1801926,1801978..1802071)) VII 1 NT_166526.1 Function: Notchless protein of D. melanogaster binds to the cytoplasmic domain of Notch, suggesting that it serves as a direct regulator of Notch signaling activity.; Remark: WD-repeat proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as signal transduction, transcription, and proliferation.; Similarity: similarity to WD40-domain containing DNA-binding proteins.; Title: similarity to protein Notchless - Drosophila melanogaster; cytoplasm; See PMID 9590294; See PMID 9857191; uncharacterized protein 1802071 84592347 An11g07530 Aspergillus niger uncharacterized protein XP_059601660.1 1798104 R 5061 CDS An11g07550 4984974 complement(join(1803685..1804736,1804796..1805356,1805584..1805622,1805709..1805814,1805959..1805993,1806058..1806110,1806160..1806221)) VII 1 NT_166526.1 Catalytic activity: Pyruvate + lipoamide = S-acetyldihydrolipoamide + CO(2).; Title: weak similarity to pyruvate dehydrogenase pdhA - Alcaligenes eutrophus; uncharacterized protein 1806221 4984974 An11g07550 Aspergillus niger uncharacterized protein XP_001394724.3 1803685 R 5061 CDS An11g07560 84592348 complement(join(1806391..1806508,1806608..1806653,1806701..1806917,1806963..1807128,1807349..1807515)) VII 1 NT_166526.1 hypothetical protein 1807515 84592348 An11g07560 Aspergillus niger hypothetical protein XP_059601661.1 1806391 R 5061 CDS An11g07570 4984976 join(1807803..1807845,1807897..1807985,1808051..1808605) VII 1 NT_166526.1 Similarity: similarity corresponds to a short internal region.; Title: weak similarity to dsRNA-binding protein 4F.2 - Xenopus laevis; See PMID 7922339; uncharacterized protein 1808605 4984976 An11g07570 Aspergillus niger uncharacterized protein XP_001394726.1 1807803 D 5061 CDS An11g07580 84592349 complement(join(1808675..1808786,1808850..1808992)) VII 1 NT_166526.1 hypothetical protein 1808992 84592349 An11g07580 Aspergillus niger hypothetical protein XP_059601662.1 1808675 R 5061 CDS An11g07590 4984978 join(1810119..1810244,1810295..1810423,1810472..1810559,1810595..1810723,1810771..1810912,1810975..1811994,1812046..1814551) VII 1 NT_166526.1 Function: the A. thaliana CAF gene product contains an N-terminal DExH/DEAD-box type RNA helicase domain attached to a C-terminal RNaseIII-like domain; it may act through some type of RNA processing event(s); Title: similarity to RNA helicase/RNAseIII CAF -Arabidopsis thaliana; See PMID 10556049; uncharacterized protein 1814551 4984978 An11g07590 Aspergillus niger uncharacterized protein XP_001394728.3 1810119 D 5061 CDS An11g07600 4984979 join(1816104..1816456,1816547..1817186) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein encoded by An14g05440 - Aspergillus niger; uncharacterized protein 1817186 4984979 An11g07600 Aspergillus niger uncharacterized protein XP_059601663.1 1816104 D 5061 CDS An11g07610 4984980 complement(join(1818264..1818620,1818683..1818974,1819021..1819444,1819604..1820438)) VII 1 NT_166526.1 Similarity: the ORF encoded protein shows also weak similarity to putative transcriptional regulator C1327. 01C from Schizosaccharomyces pombe.; Title: weak similarity to transcriptional activator Mut3 - Pichia angusta; uncharacterized protein 1820438 4984980 An11g07610 Aspergillus niger uncharacterized protein XP_059604307.1 1818264 R 5061 CDS An11g07620 84592350 join(1820779..1820926,1820982..1822000) VII 1 NT_166526.1 Similarity: weak similarity to short internal region of DNA-directed DNA polymerase catalytic chain -Trypanosoma brucei.; Title: strong similarity to hypothetical protein encoded by An08g09040 - Aspergillus niger; uncharacterized protein 1822000 84592350 An11g07620 Aspergillus niger uncharacterized protein XP_059604308.1 1820779 D 5061 CDS An11g07630 4984982 complement(join(1822080..1822137,1822257..1822287,1822344..1823410,1823473..1823676,1823879..1823885,1824061..1824146,1824238..1824296)) VII 1 NT_166526.1 Remark: two isoforms of the MCT transporter have been isolated from R. norvegicus, catalyzing the lactic acid efflux from white skeletal muscle; differences of both isoforms MCT1 and MCT3 correspond to their regulation rather than their intrinsic properties.; Title: strong similarity to monocarboxylate transporter MCT3 - Rattus norvegicus; See PMID 9632638; See PMID 10358105; See PMID 10510291; uncharacterized protein 1824296 4984982 An11g07630 Aspergillus niger uncharacterized protein XP_001394732.3 1822080 R 5061 CDS An11g07640 4984983 join(1824637..1824976,1825035..1825339,1825450..1825558,1825616..1825803) VII 1 NT_166526.1 Alternative name: protein kinase clk; Function: the M. musculus Clk protein, expressed in bacteria, becomes efficiently phosphorylated in vitro on tyrosine as well as serine/threonine, and phosphorylates the exogenous substrate poly(glu, tyr) on tyrosine.; Title: similarity to protein kinase STY - Mus musculus; See PMID 1825055; uncharacterized protein 1825803 4984983 An11g07640 Aspergillus niger uncharacterized protein XP_059604309.1 1824637 D 5061 CDS An11g07650 4984984 join(1826012..1826192,1826249..1826430,1826488..1826925) VII 1 NT_166526.1 Catalytic activity: donor + H(2)O(2) = oxidized donor + 2H(2)O.; Remark: AOP2 from mouse is higly expressed in heart,kidney and liver.; Remark: a synonyme for AOP2 from mouse is LTW4.; Title: strong similarity to antioxidant protein AOP2 - Mus musculus; See PMID 9205120; See PMID 9806838; uncharacterized protein 1826925 4984984 An11g07650 Aspergillus niger uncharacterized protein XP_001394734.1 1826012 D 5061 CDS An11g07660 4984985 join(1827591..1828658,1828705..1829717,1829766..1830177) VII 1 NT_166526.1 Catalytic activity: Successive hydrolysis of beta-D-glucose units from the non-reducing ends of 1,3-beta-D-glucans, releasing alpha-glucose.; Remark: beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall, could also function biosynthetically as a transglycosylase.; Title: similarity to exo-1,3-beta-glucanase Xog -Candida ablicans; uncharacterized protein 1830177 4984985 An11g07660 Aspergillus niger uncharacterized protein XP_001394735.1 1827591 D 5061 CDS An11g07670 4984986 join(1831018..1831729,1831783..1832208,1832397..1832516,1832603..1832685,1832797..1833516,1833697..1833823,1834032..1834078,1834147..1834887) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein EAA61442.1 - Aspergillus nidulans; uncharacterized protein 1834887 4984986 An11g07670 Aspergillus niger uncharacterized protein XP_059604310.1 1831018 D 5061 CDS An11g07680 4984987 complement(join(1835334..1836846,1836934..1837036,1837104..1837134)) VII 1 NT_166526.1 Alternative name: YDR299W (MIPS); Function: the S. cerevisiae BFR2 gene product partially suppresses the growth defects induced by the fungal metabolite Brefeldin A (BFA), which disrupts the Golgi apparatus and its incoming protein flux.; Title: strong similarity to brefeldin A resistance protein Bfr2 - Saccharomyces cerevisiae; See PMID 9472076; See PMID 9645427; uncharacterized protein 1837134 4984987 An11g07680 Aspergillus niger uncharacterized protein XP_001394737.3 1835334 R 5061 CDS An11g07690 4984988 join(1837445..1837501,1837559..1837694,1837763..1837882,1837940..1838600,1838646..1838676) VII 1 NT_166526.1 Similarity: patentmatch against cytoplasmic protein W21013 Patentprot.; Title: similarity to cytoplasmic protein hp5e15211orf13 from patent WO9640893-A1 - Helicobacter pylori; cytoplasm; uncharacterized protein 1838676 4984988 An11g07690 Aspergillus niger uncharacterized protein XP_001394738.3 1837445 D 5061 CDS An11g07700 4984989 complement(join(1838887..1840082,1840173..1840924,1840971..1841112,1841240..1841705,1841817..1841885)) VII 1 NT_166526.1 Similarity: patentmatch against esterase es4 W23084 Patentprot.; Title: similarity to esterase es4 from patent WO9730160-A1 - Cetacea sp.; uncharacterized protein 1841885 4984989 An11g07700 Aspergillus niger uncharacterized protein XP_059604311.1 1838887 R 5061 CDS An11g07710 4984990 complement(join(1843122..1843272,1843360..1843712,1843767..1844058,1844120..1844406)) VII 1 NT_166526.1 hypothetical protein 1844406 4984990 An11g07710 Aspergillus niger hypothetical protein XP_059604312.1 1843122 R 5061 CDS An11g07720 4984991 join(1845010..1845044,1845093..1846146) VII 1 NT_166526.1 hypothetical protein 1846146 4984991 An11g07720 Aspergillus niger hypothetical protein XP_059604313.1 1845010 D 5061 CDS An11g07730 84592351 complement(join(1847720..1847767,1847812..1847866,1848072..1848194,1848454..1848928,1848985..1849594,1849668..1849733,1849802..1849953,1850005..1850566)) VII 1 NT_166526.1 Similarity: the similarities of the ORF encoded protein to Muc4 from H. sapiens and the other proteins are mainly based on repetitive structures.; Title: similarity to mucin MUC4 - Homo sapiens; See PMID 10851560; uncharacterized protein 1850566 84592351 An11g07730 Aspergillus niger uncharacterized protein XP_059604314.1 1847720 R 5061 CDS An11g07740 4984993 join(1850932..1851409,1851462..1852306) VII 1 NT_166526.1 hypothetical protein 1852306 4984993 An11g07740 Aspergillus niger hypothetical protein XP_001394743.1 1850932 D 5061 CDS An11g07750 4984994 1853555..1854556 VII 1 NT_166526.1 Remark: the patent does not provide information about enzymatic activity of the protein.; Remark: the patent match is against the protein sequence of patent WO9621732-A/1 (AC# A52373).; Remark: the patented protein p43 and related polypeptide(s) which bind to interleukin receptor will be useful for treatment and diagnosis of IL-2 related disease,and to study mechanism of IL-2 mediated signal transduction.; Title: strong similarity to interleukin-2 receptor associated protein p43 from patent WO9621732-A - Mus musculus; uncharacterized protein 1854556 4984994 An11g07750 Aspergillus niger uncharacterized protein XP_001394744.3 1853555 D 5061 CDS An11g07760 4984995 complement(1854621..1855895) VII 1 NT_166526.1 Remark: the patent does not give information about the function of the protein.; Similarity: the predicted A. niger protein shows strong similarity to protein sequence 365 from patent WO0100843 (AC# AX064083) and several putative peptidases.; Title: strong similarity to sequence 365 from patent WO0100843 - Corynebacterium glutamicum; uncharacterized protein 1855895 4984995 An11g07760 Aspergillus niger uncharacterized protein XP_001394745.3 1854621 R 5061 CDS An11g07770 84592352 complement(join(1856276..1856396,1856567..1856676,1856761..1856874,1857000..1857111,1857371..1857557,1857641..1857753,1858028..1858131)) VII 1 NT_166526.1 hypothetical protein 1858131 84592352 An11g07770 Aspergillus niger hypothetical protein XP_059604315.1 1856276 R 5061 CDS An11g07780 4984997 join(1858240..1858434,1858499..1859280,1859339..1861074,1861145..1861455,1861532..1861695,1861768..1861817,1861934..1862330,1862387..1863137) VII 1 NT_166526.1 Function: Mrp2 of O. cuniculus mediates hepatobiliary excretion of numerous organic anions. Mrp2 of O. cuniculus confers a cAMP-activated chloride conductance that is inhibited by the chloride channel blockers niflumic acid, 5-nitro-2-(3-phenylpropylamine)benzoic acid,and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid.; Localization: Mrp2 of O. cuniculus is an integral protein of the apical membrane of epithelial cells.; Similarity: the predicted A. niger protein shows similarity to multidrug resistance-associated protein Mrp2 of several mammalian species. Mrp2 belongs to the MRP subfamily within the ATP- binding transport protein family (ABC transporters).; Tissue specificity: Mrp2 of O. cuniculus is expressed in liver, kidney and small intestine.; Title: strong similarity to multidrug resistance-associated protein Mrp2 - Oryctolagus cuniculus; plasma membrane; See PMID 8643587; See PMID 9614209; uncharacterized protein 1863137 4984997 An11g07780 Aspergillus niger uncharacterized protein XP_001394747.1 1858240 D 5061 CDS An11g07790 84592353 complement(join(1863391..1863656,1863918..1864256,1864306..1864450)) VII 1 NT_166526.1 Title: similarity to hypothetical protein encoded by An14g02830 - Aspergillus niger; uncharacterized protein 1864450 84592353 An11g07790 Aspergillus niger uncharacterized protein XP_059604316.1 1863391 R 5061 CDS An11g07800 84592354 1865443..1867536 VII 1 NT_166526.1 Function: the human erythrocyte ankyrin ANK1 attachs integral membrane proteins to cytoskeletal elements. it binds to the erythrocyte membrane protein band 4. 2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein.; Title: similarity to erythrocyte splice form 1 of ankyrin ANK1 - Homo sapiens; cytoskeleton; See PMID 8226993; See PMID 8640229; See PMID 1689849; uncharacterized protein 1867536 84592354 An11g07800 Aspergillus niger uncharacterized protein XP_059604317.1 1865443 D 5061 CDS An11g07810 84592355 complement(join(1867777..1868402,1868584..1868587)) VII 1 NT_166526.1 Title: weak similarity to hypothetical protein BAC69913.1 - Streptomyces avermitilis; uncharacterized protein 1868587 84592355 An11g07810 Aspergillus niger uncharacterized protein XP_059604318.1 1867777 R 5061 CDS An11g07820 4985001 join(1868907..1869113,1869165..1869917,1869974..1870253,1870600..1871493,1871553..1871894,1871960..1872083,1872157..1872228,1872285..1872400,1872504..1873128,1873237..>1873908) VII 1 NT_166526.1 Function: MRP-enriched membrane vesicles have demonstrated that the protein can bind and transport cysteinyl leukotrienes, as well as some other glutathione conjugates, with high affinity. in contrast, there is no direct evidence of the ability of MRP to bind or transport unmodified forms of the drugs to which it confers resistance. cells transfected with MRP displayed increased resistance to vincristine (5-6-fold) and doxorubicin (< 2-fold).; Similarity: the predicted protein of A. niger shows similarity to fungal and mammalian multidrug-resistance proteins (MRP).; Tissue specificity: MRP mRNA expression in some tissues is cell-type specific.; Title: strong similarity to multidrug resistance protein MRP - Mus musculus [putative frameshift]; plasma membrane; putative frameshift; See PMID 8649356; uncharacterized protein 1873908 4985001 An11g07820 Aspergillus niger uncharacterized protein XP_059604319.1 1868907 D 5061 CDS An11g07830 4985002 join(1875521..1875826,1875891..1876451,1876504..1876620,1876670..1876951,1877001..1877264,1877319..1877496,1877548..1878266) VII 1 NT_166526.1 Title: strong similarity to hypothetical peptide transporter mtd1 - Schizophyllum commune; See PMID 10501939; uncharacterized protein 1878266 4985002 An11g07830 Aspergillus niger uncharacterized protein XP_059604320.1 1875521 D 5061 CDS An11g07840 4985003 complement(join(1878828..1879210,1879291..1879654)) VII 1 NT_166526.1 Similarity: similarities may be due to repetitive sequences.; hypothetical protein 1879654 4985003 An11g07840 Aspergillus niger hypothetical protein XP_001394753.1 1878828 R 5061 CDS An11g07850 84592356 join(1880408..1880411,1880444..1880598,1880671..1880739,1880841..1880926,1880967..1881170,1881229..1881280) VII 1 NT_166526.1 hypothetical protein 1881280 84592356 An11g07850 Aspergillus niger hypothetical protein XP_059604321.1 1880408 D 5061 CDS An11g07870 84592357 complement(join(1882254..1882343,1882520..1882719,1882817..1883083,1883172..1883287,1883410..1883517,1883603..1883715)) VII 1 NT_166526.1 hypothetical protein 1883715 84592357 An11g07870 Aspergillus niger hypothetical protein XP_059604322.1 1882254 R 5061 CDS An11g07875 4985007 1884033..1884632 VII 1 NT_166526.1 hypothetical protein 1884632 4985007 An11g07875 Aspergillus niger hypothetical protein XP_001394756.1 1884033 D 5061 CDS An11g07880 84592358 join(1884778..1884921,1885030..1885175,1885399..1885479,1885841..1886031,1886124..1886185,1886492..1886525,1886753..1886916,1887139..1887204) VII 1 NT_166526.1 hypothetical protein 1887204 84592358 An11g07880 Aspergillus niger hypothetical protein XP_059604323.1 1884778 D 5061 CDS An11g07900 84592359 join(1887743..1887855,1887946..1888002,1888146..1888459,1888511..1888669,1888754..1888882,1888967..1889017,1889102..1889271) VII 1 NT_166526.1 Title: similarity to hypothetical protein encoded by An16g02740 - Aspergillus niger; uncharacterized protein 1889271 84592359 An11g07900 Aspergillus niger uncharacterized protein XP_059604324.1 1887743 D 5061 CDS An11g07910 4985011 join(1889557..1889985,1890029..1890046,1890113..1890841) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein encoded by An18g04450 - Aspergillus niger; uncharacterized protein 1890841 4985011 An11g07910 Aspergillus niger uncharacterized protein XP_059604325.1 1889557 D 5061 CDS An11g07920 4985012 join(1891184..1891196,1891337..1891506) VII 1 NT_166526.1 Remark: the protein sequence of patent WO200055320-A1 (AC# AAB54096) covers a ribosomal protein L33-like protein. the same sequence is covered by another patent WO9936524-A1 (AC# AAY29322).; Title: similarity to pancreatic cancer antigen from patent WO200055320-A1 - Homo sapiens; mitochondrial 54S ribosomal protein bL33m 1891506 4985012 An11g07920 Aspergillus niger mitochondrial 54S ribosomal protein bL33m XP_001394760.1 1891184 D 5061 CDS An11g07930 4985013 complement(join(1892127..1892164,1892212..1893781,1893830..1893880,1893933..1894653,1894711..1895726,1895777..1895808,1895859..1896103,1896145..1896551)) VII 1 NT_166526.1 Complex: desmoplakin of H. sapiens forms a two-stranded coiled coil structure.; Function: desmoplakin of H. sapiens may play a role in attaching intermediate filaments to the cell surface.; Localization: human desmoplakin is found at the innermost portion of the desmosomal plaque.; Remark: human dpI and dpII derive from the same gene by alternative splicing.; Remark: the patent match is against the protein sequence breast cancer associated antigen precursor of patent WO9904265-A2 (AC# AAY07031), which covers the C-terminal half of human desmoplakin.; Similarity: the predicted A. niger protein shows similarity to desmoplakin I and II (dpI and dp II) of H. sapiens and coiled-coil domains of other proteins.; Tissue specificity: dpI is apparently an obligate constituent of all desmosomes, whereas dpII resides predominantly in tissues and cells of stratified origin. desmoplakins I and II are the major high molecular weight desmosome proteins.; Title: similarity to desmoplakin I DPI - Homo sapiens; cytoskeleton; uncharacterized protein 1896551 4985013 An11g07930 Aspergillus niger uncharacterized protein XP_059604326.1 1892127 R 5061 CDS An11g07940 84592360 join(1897843..1898050,1898129..1898406) VII 1 NT_166526.1 hypothetical protein 1898406 84592360 An11g07940 Aspergillus niger hypothetical protein XP_059604327.1 1897843 D 5061 CDS An11g07950 4985015 join(1899167..1899493,1899573..1900313) VII 1 NT_166526.1 Catalytic activity: the Bacillus subtilis myo-inositol 2-dehydrogenase converts Myo-inositol and NAD(+) to 2,4,6/3,5-pentahydroxycyclohexanone and NADH.; Induction: the Bacillus subtilis myo-inositol 2-dehydrogenase is induced by myo-inositol and is strongly repressed by rapidly metabolizable carbohydrates such as D-glucose, D-mannose, D-fructose and glycerol .; Title: strong similarity to myo-inositol 2-dehydrogenase yisS - Bacillus subtilis; See PMID 6322857; uncharacterized protein 1900313 4985015 An11g07950 Aspergillus niger uncharacterized protein XP_001394763.1 1899167 D 5061 CDS An11g07960 4985016 join(1900946..1901381,1901443..1903175) VII 1 NT_166526.1 Function: the A. oryzae glutaminase is an aminohydrolase that hydrolyses glutamin to glutamate and ammonia.; Remark: the purified A. oryzae glutaminase catalysed the hydrolysis not only of L-glutamine but also of D-glutamine.; Title: strong similarity to glutaminase A gtaA -Aspergillus oryzae; See PMID 10952006; uncharacterized protein 1903175 4985016 An11g07960 Aspergillus niger uncharacterized protein XP_001394764.1 1900946 D 5061 CDS An11g07970 4985017 join(1903772..1903780,1903946..1904102,1904199..1904310,1904427..1906257) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein SPBC16H5.12c - Schizosaccharomyces pombe; uncharacterized protein 1906257 4985017 An11g07970 Aspergillus niger uncharacterized protein XP_001394765.1 1903772 D 5061 CDS An11g07980 4985018 complement(join(1908110..1908260,1908316..1909475,1909539..1910015)) VII 1 NT_166526.1 Function: YAP1 gene disruption experiments in K. lactis indicated that the gene is involved in both the oxidative and cadmium response pathways.; Function: the K. lactis YAP1 mediates AP-1 response element-dependent transcriptional activation in response to H2O2 in S. cerevisiae.; Remark: the K. lactis YAP1 was cloned by functional complementation of the mutant phenotype of a S. cerevisiae strain lacking functional YAP1 and YAP2 genes.; Remark: the similarity of the predicted A. niger protein to the transcription factor YAP1 is restricted to the N-terminal part of the A. niger protein (aa 119-222).; Title: weak similarity to transcription factor YAP1 - Kluyveromyces lactis; nucleus; See PMID 9439570; uncharacterized protein 1910015 4985018 An11g07980 Aspergillus niger uncharacterized protein XP_059604328.1 1908110 R 5061 CDS An11g07990 84592361 join(1910133..1910354,1910404..1910475,1910517..1910565,1910643..1910705,1910780..1910877) VII 1 NT_166526.1 hypothetical protein 1910877 84592361 An11g07990 Aspergillus niger hypothetical protein XP_059604329.1 1910133 D 5061 CDS An11g08000 84592362 complement(join(1910935..1911121,1911383..1911476,1911535..1911758,1911845..1911927)) VII 1 NT_166526.1 hypothetical protein 1911927 84592362 An11g08000 Aspergillus niger hypothetical protein XP_059604330.1 1910935 R 5061 CDS An11g08010 4985021 join(1912581..1912631,1912686..1913421,1913474..1913562) VII 1 NT_166526.1 Title: similarity to hypothetical protein SPCC1281.02c - Schizosaccharomyces pombe; uncharacterized protein 1913562 4985021 An11g08010 Aspergillus niger uncharacterized protein XP_001394769.1 1912581 D 5061 CDS An11g08020 4985022 complement(join(1913879..1914281,1914359..1914803,1914856..1914892,1914963..1915154)) VII 1 NT_166526.1 Function: the M. grisea Pth11p can activate appressorium differentiation in response to inductive surface cues and repress differentiation on poorly inductive surfaces.; Remark: the M. grisea PTH11, a pathogenicity gene predicted to encode a novel transmembrane protein is localized in the cell membrane and in vacuoles.; Title: strong similarity to G-11 integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529; uncharacterized protein 1915154 4985022 An11g08020 Aspergillus niger uncharacterized protein XP_001394770.1 1913879 R 5061 CDS An11g08030 4985023 join(1915848..1916683,1916740..1917273,1917328..1917482,1917550..1917686) VII 1 NT_166526.1 Function: the A. nidulans STCW may be involved in the hydroxylatioin of averantin to 5'-hydroxyaverantin.; Pathway: The ST biosynthetic pathway in Aspergillus nidulans is estimated to involve at least 15 enzymatic activities; Remark: Sterigmatocystin (ST) is a mycotoxin with the molecular formula C18 H12 O6 who is closly related to alflatoxin and produced by several species of Aspergillus sp.; Title: strong similarity to hypothetical sterigmatocystin biosythesis monooxygenase stcW -Aspergillus nidulans; See PMID 8643646; uncharacterized protein 1917686 4985023 An11g08030 Aspergillus niger uncharacterized protein XP_001394771.1 1915848 D 5061 CDS An11g08040 84592363 complement(join(1917775..1917839,1917880..1917951,1918021..1918055,1918153..1918210,1918260..1918355,1918845..1918908)) VII 1 NT_166526.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1918908 84592363 An11g08040 Aspergillus niger uncharacterized protein XP_059604331.1 1917775 R 5061 CDS An11g08050 4985025 complement(join(1919301..1920105,1920161..1920234)) VII 1 NT_166526.1 Remark: the AKT2 protein is involved in production and pathogenicity of the fungal AK-toxin, which is a pathotype called black spot on japanese pears.; Title: strong similarity to hypothetical protein required for biosynthesis of the host-specific AK-toxin Akt2 - Alternaria alternata; See PMID 10432635; uncharacterized protein 1920234 4985025 An11g08050 Aspergillus niger uncharacterized protein XP_001394773.3 1919301 R 5061 CDS An11g08060 4985026 complement(join(1921393..1922623,1922676..1923256)) VII 1 NT_166526.1 Function: the M. musculus HCDH catalyzes the reduction of 3-hydroxyacyl-CoA to 3-oxoacyl-CoA.; Localization: the M. musculus HCDH is predicted to be in at least two different compartments of the cell, the mitochondria and the peroxisomes.; Pathway: the M. musculus 3-hydroxyacyl-CoA dehydrogenase (HCDH) is an enzyme involved in fatty acid metabolism.; Remark: the similarity of the predicted A. niger protein to the M. musculus HCDH is restricted to the N-terminal region.; Similarity: the predicted A. niger protein contains the dehydratase domain (aa 194-204, PF00725) as well as the NAD-binding domain (aa 0-192, PF02737).; Title: similarity to 3-hydroxyacyl-CoA dehydrogenase HCDH - Mus musculus; See PMID 7642117; uncharacterized protein 1923256 4985026 An11g08060 Aspergillus niger uncharacterized protein XP_001394774.1 1921393 R 5061 CDS An11g08070 4985027 complement(1923927..1925678) VII 1 NT_166526.1 Catalytic activity: the H. sapiens acetylcholinesterase catalyses the cleavage of acetylcholine and H(2)O to choline and acetate thus reducing the concentration of the neurotransmitter acetycholin within the neural cleft.; Complex: acetylcholinesterase of H. spaiens exists a homodimer linked by a disulfide bridge.; Remark: the human acetylcholinsterase acts on a variety of acetic esters; also catalyses transacetylations and is inhibited by tacrine.; Title: strong similarity to acetylcholinesterase ACHE - Homo sapiens; See PMID 2263619; See PMID 2714437; uncharacterized protein 1925678 4985027 An11g08070 Aspergillus niger uncharacterized protein XP_001394775.1 1923927 R 5061 CDS An11g08080 4985028 complement(join(1926679..1926992,1927052..1927506,1927555..1927684,1927751..1928051)) VII 1 NT_166526.1 Catalytic activity: O-methyltransferase I catalyzes both the conversion of demethylsterigmatocystin to sterigmatocystin and the conversion of dihydrodemethylsterigmatocystin to dihydrosterigmatocystin during aflatoxin biosynthesis.; Remark: sterigmatocystin (ST) is a mycotoxin with the molecular formula C18 H12 O6, which is closly related to alflatoxin and produced by several species of Aspergillus sp.; Remark: the predicted A. niger protein contains a PF00891 O-methyltransferase consensus sequenze (aa 119-374) and a leucin zipper domain (aa 249-278).; Title: strong similarity to cDNA O-methyltransferase mt-I - Aspergillus parasiticus; See PMID 10543813; uncharacterized protein 1928051 4985028 An11g08080 Aspergillus niger uncharacterized protein XP_001394776.1 1926679 R 5061 CDS An11g08090 84592364 join(1928557..1928609,1928781..1928903,1929311..1929412,1929571..1929715) VII 1 NT_166526.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1929715 84592364 An11g08090 Aspergillus niger uncharacterized protein XP_059604332.1 1928557 D 5061 CDS An11g08100 4985030 complement(join(1930059..1930762,1930877..1931006)) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein encoded by An12g06830 - Aspergillus niger; uncharacterized protein 1931006 4985030 An11g08100 Aspergillus niger uncharacterized protein XP_059604333.1 1930059 R 5061 CDS An11g08110 84592365 complement(join(1931246..1931327,1931413..1931539,1931622..1931701,1931738..1931857,1932047..1932230,1932301..1932304)) VII 1 NT_166526.1 hypothetical protein 1932304 84592365 An11g08110 Aspergillus niger hypothetical protein XP_059604334.1 1931246 R 5061 CDS An11g08120 4985032 join(1932941..1933068,1933112..1933239,1933316..1933446) VII 1 NT_166526.1 Similarity: the ORF encoded protein shows also weak similarity to cDNA hypothetical serine-rich protein SPCC553. 10 from Schizosaccharomyces pombe.; Title: weak similarity to hypothetical protein encoded by An11g05490 - Aspergillus niger; uncharacterized protein 1933446 4985032 An11g08120 Aspergillus niger uncharacterized protein XP_059604335.1 1932941 D 5061 CDS An11g08130 4985033 join(1934272..1934456,1934650..1934767,1934862..1935449) VII 1 NT_166526.1 Pathway: the D. melanogaster SRPK1 identified as a kinase specific for the SR family of splicing factors.; Remark: the similarity between the predicted A. niger protein and the D. melanogaster SRPK1 protein is restricted to the Serin/threonin kinase domain (aa 15 - 59,COG0515).; Title: weak similarity to SR protein kinase 1 SRPK1 - Drosophila melanogaster; See PMID 11158320; uncharacterized protein 1935449 4985033 An11g08130 Aspergillus niger uncharacterized protein XP_059604336.1 1934272 D 5061 CDS An11g08140 4985034 complement(join(1935789..1936385,1936442..1936533,1936585..1936825)) VII 1 NT_166526.1 Catalytic activity: endonucleolytic cleavage to 5'-phosphomononucleotide and 5'-phosphooligonucleotide end-products.; Complex: nucS of A. oryzae exists as a monomer.; Function: the A. oryzae nuclease S1 hydrolyses single stranded DNA from protuding ends or endonucleolytical.; Title: strong similarity to nuclease S1 gene nucS -Aspergillus oryzae; See PMID 8597544; See PMID 1939022; uncharacterized protein 1936825 4985034 An11g08140 Aspergillus niger uncharacterized protein XP_001394782.1 1935789 R 5061 CDS An11g08150 4985035 complement(join(1937701..1937733,1937866..1938900)) VII 1 NT_166526.1 Remark: the predicted A. niger protein exhibits also local similarity to the hypothetical yukJ from B. subtilis within its central part (aa 138-230).; Title: strong similarity to hypothetical protein BAB74777.1 - Nostoc sp.; uncharacterized protein 1938900 4985035 An11g08150 Aspergillus niger uncharacterized protein XP_001394783.3 1937701 R 5061 CDS An11g08160 4985036 join(1940036..1940069,1940137..1940313,1940372..1941393) VII 1 NT_166526.1 Remark: the similarity of the predicted A. niger protein (aa 2-277) is restricted to the N-terminal part of the to the C. crescentus protein.; Title: similarity to hypothetical peptidoglycan binding domain protein CC2696 - Caulobacter crescentus; uncharacterized protein 1941393 4985036 An11g08160 Aspergillus niger uncharacterized protein XP_059604337.1 1940036 D 5061 CDS An11g08170 4985037 complement(join(1941689..1942283,1942340..1942525,1942603..1942721)) VII 1 NT_166526.1 hypothetical protein 1942721 4985037 An11g08170 Aspergillus niger hypothetical protein XP_059604338.1 1941689 R 5061 CDS An11g08180 4985038 join(1943477..1944263,1944318..1947514) VII 1 NT_166526.1 Title: similarity to hypothetical protein slr1968 -Synechocystis sp.; uncharacterized protein 1947514 4985038 An11g08180 Aspergillus niger uncharacterized protein XP_059604339.1 1943477 D 5061 CDS An11g08190 4985039 join(1948048..1948272,1948484..1948794,1948854..1949988) VII 1 NT_166526.1 Remark: when expressed in Xenopus oocytes, the encoded protein of the rat designated as TAT1 (T-type amino acid transporter 1) exhibited Na+-independent and low-affinity transport of aromatic amino acids such as tryptophan, tyrosine, and phenylalanine (Km values: approximately 5 mm), consistent with the properties of classical amino acid transport system T. Distinct from H+/monocarboxylate transporters, however, TAT1 was not coupled with the H+ transport but it mediated an electroneutral facilitated diffusion.; Similarity: belongs to the permeases of the major facilitator superfamily.; Title: strong similarity to T-type amino acid transporter 1 TAT1 - Rattus norvegicus; See PMID 11278508; uncharacterized protein 1949988 4985039 An11g08190 Aspergillus niger uncharacterized protein XP_001394787.3 1948048 D 5061 CDS An11g08200 4985040 complement(1950287..1951504) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein EAA59978.1 - Aspergillus nidulans; uncharacterized protein 1951504 4985040 An11g08200 Aspergillus niger uncharacterized protein XP_001394788.3 1950287 R 5061 CDS An11g08210 84592366 complement(join(1952167..1952202,1952351..1952425,1952631..1952650,1952730..1953116,1953191..1953629,1953747..1953782,1953838..1953840)) VII 1 NT_166526.1 hypothetical protein 1953840 84592366 An11g08210 Aspergillus niger hypothetical protein XP_059604340.1 1952167 R 5061 CDS An11g08220 4985042 join(1954075..1954179,1954532..1954547,1954840..1954894,1955196..1955628,1955680..1955778,1955841..1955952,1956019..1956271,1956328..1956451,1956498..1956595,1956645..1956662,1956711..1956903,1956960..1957101,1957159..1957358) VII 1 NT_166526.1 Remark: similarity to Neisseria meningitidis Hsp70 patent WO200034465-A2.; Title: similarity to heat shock protein 70 Hsp70 from patent WO200034465-A2 - Neisseria meningitidis; uncharacterized protein 1957358 4985042 An11g08220 Aspergillus niger uncharacterized protein XP_059604341.1 1954075 D 5061 CDS An11g08230 84592367 complement(join(1957842..1957949,1958018..1958033,1958096..1958594,1958732..1958789)) VII 1 NT_166526.1 hypothetical protein 1958789 84592367 An11g08230 Aspergillus niger hypothetical protein XP_059604342.1 1957842 R 5061 CDS An11g08240 84592368 complement(join(1959321..1959477,1959860..1960009,1960073..1960209,1960631..1960756)) VII 1 NT_166526.1 Title: questionable ORF; uncharacterized protein 1960756 84592368 An11g08240 Aspergillus niger uncharacterized protein XP_059604343.1 1959321 R 5061 CDS An11g08250 4985045 complement(join(1961995..1962679,1962735..1963759,1963810..1963918,1963977..1964538,1964591..1964959,1965018..1965429)) VII 1 NT_166526.1 Title: strong similarity to tyrosine decarboxylase tyrDC - Enterococcus faecalis; See PMID 12089039; uncharacterized protein 1965429 4985045 An11g08250 Aspergillus niger uncharacterized protein XP_001394793.3 1961995 R 5061 CDS An11g08260 4985046 complement(join(1966604..1966769,1966869..1967086)) VII 1 NT_166526.1 Remark: similarity to Arabidopsis thaliana protein fragment SEQ ID NO: 58222 patent EP1033405-A2.; Title: similarity to protein fragment SEQ ID NO:58222 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 1967086 4985046 An11g08260 Aspergillus niger uncharacterized protein XP_001394794.1 1966604 R 5061 CDS An11g08280 4985048 complement(join(1967994..1968769,1968835..1969348)) VII 1 NT_166526.1 Remark: Northern blotting revealed a unique tissue distribution for the expression of mRNA for MTC3. MTC3 is expressed in retinal pigment epithelium (RPE).; Title: similarity to monocarboxylate transporter MCT3 - Homo sapiens; See PMID 9425115; See PMID 10493836; uncharacterized protein 1969348 4985048 An11g08280 Aspergillus niger uncharacterized protein XP_001394795.1 1967994 R 5061 CDS An11g08290 84592369 complement(join(1970222..1970843,1970924..1971471)) VII 1 NT_166526.1 Function: FAH is a cytochrome P450-linked monoxygenase, which catalyses the conversion of ferulic acid to 5-hydroxyferulic acid, which is an internediate of sinapine.; Remark: similarity to Amino acid sequence of pJOY3 ferulic acid hydroxylase cDNA clone patent CA2270417-A1.; Title: similarity to ferulic acid hydroxylase FAH from patent CA2270417-A1 - Brassica napus; uncharacterized protein 1971471 84592369 An11g08290 Aspergillus niger uncharacterized protein XP_059604344.1 1970222 R 5061 CDS An11g08300 84592370 join(1972177..1972266,1972395..1972448) VII 1 NT_166526.1 Remark: the ORF is short in length (47 amino acids) and has an unusual exon/intron structure for A. niger.; Title: questionable ORF; uncharacterized protein 1972448 84592370 An11g08300 Aspergillus niger uncharacterized protein XP_059604345.1 1972177 D 5061 CDS An11g08320 4985052 complement(join(1973117..1973119,1973190..1973266,1973489..1974074,1974130..1974623,1974687..1974873,1974932..1975237)) VII 1 NT_166526.1 Remark: FLR1 S. cerevisiae gene confers resistance to the antimitotic systemic benzimidazole fungicide benomyl and the antitumor agent methotrexate, reinforcing the concept that the FLR1 gene is a multidrug resistance (MDR) determinant. activation of FLR1 expression in benomyl-stressed cells is under the control of the transcriptional regulator Pdr3p.; Remark: alternative name is YBR008c.; Similarity: belongs to the permeases of the major facilitator superfamily and the benomyl/methotrexate resistance protein family.; Title: strong similarity to fluconazole resistance transporter Flr1 - Saccharomyces cerevisiae; See PMID 10572257; uncharacterized protein 1975237 4985052 An11g08320 Aspergillus niger uncharacterized protein XP_059604346.1 1973117 R 5061 CDS An11g08330 4985053 complement(join(1975958..1975993,1976058..1976517,1976592..1976803,1976857..1977272,1977304..1977601)) VII 1 NT_166526.1 Remark: strong similarity to Pseudomonas sp. WF505 ORF6-6 protein, SEQ ID NO:11 patent JP2000093180-A found in PATENTPROT:AAY97823.; Remark: the decribed Pseudomonas sp. WF505 protein is believed to be useful for the desulfurization of crude oil as component of the benzothiophene oxidase gene cluster of Pseudomonas sp. WF505.; Title: strong similarity to ORF6-6 protein from patent JP2000093180-A - Pseudomonas sp.; See PMID 8021182; See PMID 9783422; uncharacterized protein 1977601 4985053 An11g08330 Aspergillus niger uncharacterized protein XP_059604347.1 1975958 R 5061 CDS An11g08340 84592371 complement(join(1977709..1978115,1978145..1978535)) VII 1 NT_166526.1 Title: similarity to hypothetical protein encoded by An02g12600 - Aspergillus niger; uncharacterized protein 1978535 84592371 An11g08340 Aspergillus niger uncharacterized protein XP_059604348.1 1977709 R 5061 CDS An11g08350 84592372 complement(join(1979418..1979982,1980233..1980267,1980598..1983000)) VII 1 NT_166526.1 Title: similarity to cellular proliferation protein #164 from patent WO200170955-A2 - Streptococcus pneumoniae; uncharacterized protein 1983000 84592372 An11g08350 Aspergillus niger uncharacterized protein XP_059604349.1 1979418 R 5061 CDS An11g08360 84592373 1983795..1985399 VII 1 NT_166526.1 hypothetical protein 1985399 84592373 An11g08360 Aspergillus niger hypothetical protein XP_059604350.1 1983795 D 5061 CDS An11g08370 4985057 complement(join(1985625..1985659,1985716..1987660)) VII 1 NT_166526.1 Function: het-6 of N. crassa is involved in the restriction of heterokaryon formation during asexual growth.; Remark: in filamentous fungi, vegetative cell fusion between genotypically distinct individuals leads to a cell-death reaction known as vegetative or heterokaryon incompatibility.; Similarity: het-6(OR) of N. crassa has three regions of amino acid sequence similarity to the predicted product of the het-e vegetative incompatibility gene in P. anserina and to the predicted product of tol, which mediates mating-type vegetative incompatibility in N. crassa.; Title: similarity to heterokaryon incompatibility protein het-6 - Neurospora crassa; See PMID 10880472; See PMID 11035941; See PMID 11092825; uncharacterized protein 1987660 4985057 An11g08370 Aspergillus niger uncharacterized protein XP_001394803.1 1985625 R 5061 CDS An11g08380 84592374 join(1988865..1988908,1989178..1989421) VII 1 NT_166526.1 hypothetical protein 1989421 84592374 An11g08380 Aspergillus niger hypothetical protein XP_059604351.1 1988865 D 5061 CDS An11g08390 84592375 1992526..1995051 VII 1 NT_166526.1 Similarity: similarity is from the N-terminal region of the predicted A. niger protein to the C-terminal region of Agrobacterium tumefaciens, which is 371 aa long.; Title: weak similarity to hypothetical protein ymc -Argrobacterium tumefaciens; uncharacterized protein 1995051 84592375 An11g08390 Aspergillus niger uncharacterized protein XP_059604352.1 1992526 D 5061 CDS An11g08400 4985060 complement(join(1996285..1997772,1997828..1997938)) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein YEL023c - Saccharomyces cerevisiae; uncharacterized protein 1997938 4985060 An11g08400 Aspergillus niger uncharacterized protein XP_059604353.1 1996285 R 5061 CDS An11g08410 4985061 join(1998667..1998771,1998833..1999255,1999313..1999801) VII 1 NT_166526.1 Function: members of the quinone reductase family are catalyzing the nicotinamide nucleotide-dependent reduction of quinones to reduce their toxic effects.; Title: strong similarity to zeta-crystallin / quinone reductase CYGPZ - Cavia porcellus; See PMID 1370456; See PMID 11340659; See PMID 1989495; uncharacterized protein 1999801 4985061 An11g08410 Aspergillus niger uncharacterized protein XP_059604354.1 1998667 D 5061 CDS An11g08420 84592376 complement(join(2000140..2000234,2000326..2000569,2000668..2000700)) VII 1 NT_166526.1 hypothetical protein 2000700 84592376 An11g08420 Aspergillus niger hypothetical protein XP_059604355.1 2000140 R 5061 CDS An11g08430 84592377 join(2000953..2001045,2001195..2001320,2001404..2001503,2001666..2002084) VII 1 NT_166526.1 Title: weak similarity to hypothetical protein encoded by An15g03810 - Aspergillus niger; uncharacterized protein 2002084 84592377 An11g08430 Aspergillus niger uncharacterized protein XP_059604356.1 2000953 D 5061 CDS An11g08440 4985064 complement(join(2003515..2004736,2004812..2005389)) VII 1 NT_166526.1 Function: C. acetobutylicum bcd catalyses the formation of butyryl-CoA from acetoacetyl-CoA essential for acid and solvent formation by clostridia.; Title: similarity to 3-hydroxybutyryl-CoA dehydrogenase bcd - Clostridium acetobutylicum; See PMID 8655474; uncharacterized protein 2005389 4985064 An11g08440 Aspergillus niger uncharacterized protein XP_001394810.1 2003515 R 5061 CDS An11g08450 84592378 join(2005579..2005706,2005846..2005898,2005985..2006124,2006205..2006453) VII 1 NT_166526.1 hypothetical protein 2006453 84592378 An11g08450 Aspergillus niger hypothetical protein XP_059604357.1 2005579 D 5061 CDS An11g08460 4985066 join(2006721..2006767,2006800..2007174,2007256..2007766) VII 1 NT_166526.1 Function: A. niger aox1 transfers electrons directly from ubichinol to oxygenen forming water without translocation of protons across the inner mitochondrial membrane.; Remark: the A. niger alternative oxidase is used as a second terminal oxidase in the mitochondria.; Title: strong similarity to alternative oxidase aox1 - Aspergillus niger; localisation:mitochondrion; See PMID 9933359; See PMID 11106766; uncharacterized protein 2007766 4985066 An11g08460 Aspergillus niger uncharacterized protein XP_001394812.3 2006721 D 5061 CDS An11g08470 84592379 complement(join(2007958..2008675,2008732..2009127,2009178..2010051,2010141..2010198)) VII 1 NT_166526.1 Complex: the S. cerevisiae transcription activator CHA4 interacts with two serine/threonine response elements in the CHA1 promoter, UASCHA.; Function: the S. cerevisiae transcription activator CHA4 regulates the transcription of the CHA1 gene, which encodes a catabolic L-serine (L-threonine) deaminase responsible for the utilization of serine/threonine as nitrogen sources.; Title: weak similarity to transcription activator Cha4 - Saccharomyces cerevisiae; See PMID 8889513; uncharacterized protein 2010198 84592379 An11g08470 Aspergillus niger uncharacterized protein XP_059604358.1 2007958 R 5061 CDS An11g08480 84592380 complement(join(2010723..2010726,2010818..2010934,2010983..2011173)) VII 1 NT_166526.1 hypothetical protein 2011173 84592380 An11g08480 Aspergillus niger hypothetical protein XP_059604359.1 2010723 R 5061 CDS An11g08500 4985067 complement(join(2012854..2012951,2013053..2013291,2013402..2013510,2013569..2013647,2013705..2014079)) VII 1 NT_166526.1 Complex: S. lactamdurans 7 alpha-cephem-methoxylase two-protein component system formed by cmcI and cmcJ.; Function: S. lactamdurans cmcJ forms part of the 7 alpha-cephem-methoxylase which converts the antibiotic cephalosporin C to 7-methoxycephalosporin C.; Title: similarity to hypothetical 7alpha-cephem-methoxylase subunit cmcJ - Streptomyces lactamdurans; See PMID 7721717; uncharacterized protein 2014079 4985067 An11g08500 Aspergillus niger uncharacterized protein XP_059604360.1 2012854 R 5061 CDS An11g08510 4985071 complement(2015049..2016161) VII 1 NT_166526.1 Catalytic activity: NADPH dehydrogenases catalyse the reaction, NADPH + acceptor = NADP+ + reduced acceptor.; Complex: S. cerevisiae OYE3 forms homodimers and heterodimers with other OYE Isoforms.; Function: S. cerevisiae OYE3 binds a variety of compounds with a phenolic structure.; Function: S. cerevisiae OYE3 has been shown to catalyze efficiently the NADPH-linked reduction of nitro-olefins.; Function: S. cerevisiae OYE3 might be involved in sterol metabolism.; Remark: the OYE (old yellow enzyme) of S. cerevisiae binds phenolic ligands forming long wavelength (500-800 nm) charge-transfer complexes.; Title: strong similarity to hypothetical NADPH dehydrogenase Oye3 - Saccharomyces cerevisiae; See PMID 7836424; See PMID 10995477; uncharacterized protein 2016161 4985071 An11g08510 Aspergillus niger uncharacterized protein XP_001394816.3 2015049 R 5061 CDS An11g08520 84592381 complement(2016767..2018593) VII 1 NT_166526.1 Similarity: only the N-terminal regions have similarities.; Title: weak similarity to heterokaryon incompatibility protein het-6 - Neurospora crassa; See PMID 11035941; uncharacterized protein 2018593 84592381 An11g08520 Aspergillus niger uncharacterized protein XP_059604361.1 2016767 R 5061 CDS An11g08530 4985073 complement(join(2018953..2019524,2019575..2020004)) VII 1 NT_166526.1 Catalytic activity: Z. rouxii krd reduces alpha-ketolactones, alpha-ketolactams, and diketones.; Function: Z. rouxii krd catalyzes the asymmetric reduction of selected ketone substrates like 3,4-methylenedioxyphenyl acetone.; Similarity: substrate specificity, lack of a catalytic metal, and similarity to known reductases suggests that Z. rouxii krd is a carbonyl reductase.; Title: strong similarity to ketoreductase krd -Zygosaccharomyces rouxii; See PMID 10951208; uncharacterized protein 2020004 4985073 An11g08530 Aspergillus niger uncharacterized protein XP_001394818.1 2018953 R 5061 CDS An11g08540 84592382 complement(join(2020780..2020914,2020961..2021005,2021115..2021277,2021417..2021544,2021643..2021825)) VII 1 NT_166526.1 Similarity: protein homologues due to repetitive sequence.; hypothetical protein 2021825 84592382 An11g08540 Aspergillus niger hypothetical protein XP_059604362.1 2020780 R 5061 CDS An11g08550 4985075 join(2022094..2023466,2023523..2025053) VII 1 NT_166526.1 Title: similarity to hypothetical transcription factor SPAPB1A11.04c - Schizosaccharomyces pombe; uncharacterized protein 2025053 4985075 An11g08550 Aspergillus niger uncharacterized protein XP_001394820.1 2022094 D 5061 CDS An11g08570 84592383 complement(join(2025822..2025889,2025925..2025976)) VII 1 NT_166526.1 hypothetical protein 2025976 84592383 An11g08570 Aspergillus niger hypothetical protein XP_059604363.1 2025822 R 5061 CDS An11g08580 84592384 complement(join(2026402..2026484,2026568..2026572,2026655..2026872)) VII 1 NT_166526.1 hypothetical protein 2026872 84592384 An11g08580 Aspergillus niger hypothetical protein XP_059604364.1 2026402 R 5061 CDS An11g08590 84592385 join(2027572..2027648,2027821..2027870,2027967..2028083,2028181..2028467) VII 1 NT_166526.1 hypothetical protein 2028467 84592385 An11g08590 Aspergillus niger hypothetical protein XP_059604365.1 2027572 D 5061 CDS An11g08600 84592386 join(2028747..2028803,2029191..2029462,2029600..2030005) VII 1 NT_166526.1 Title: weak similarity to JUN-like transcription factor jlbA - Aspergillus nidulans; uncharacterized protein 2030005 84592386 An11g08600 Aspergillus niger uncharacterized protein XP_059604366.1 2028747 D 5061 CDS An11g08610 4985081 complement(join(2030511..2031428,2031488..2031526)) VII 1 NT_166526.1 Remark: VC16-16MC is a thermostable esterase of Archaeoglobus fulgidus VC16.; Remark: patentmatch is a protein. accession number is W23076.; Similarity: belongs to the esterase/lipase family.; Title: strong similarity to esterase VC16-16MC from patent WO9730160-A1 - Archaeoglobus fulgidus; uncharacterized protein 2031526 4985081 An11g08610 Aspergillus niger uncharacterized protein XP_001394825.3 2030511 R 5061 CDS An11g08620 4985082 join(2033110..2033427,2033482..2034816) VII 1 NT_166526.1 Title: strong similarity to cercosporin transporter AAC78076.1 - Cercospora kikuchii; See PMID 10517030; uncharacterized protein 2034816 4985082 An11g08620 Aspergillus niger uncharacterized protein XP_001394826.1 2033110 D 5061 CDS An11g08630 84592387 complement(join(2037367..2037571,2037637..2037683,2037741..2037959,2038014..2038053,2038128..2038169,2038225..2038338,2038556..2038688,2038754..2038801,2039217..2039229)) VII 1 NT_166526.1 hypothetical protein 2039229 84592387 An11g08630 Aspergillus niger hypothetical protein XP_059604367.1 2037367 R 5061 CDS An11g08640 84592388 join(2041572..2041689,2041984..2042105,2042141..2042203) VII 1 NT_166526.1 hypothetical protein 2042203 84592388 An11g08640 Aspergillus niger hypothetical protein XP_059604368.1 2041572 D 5061 CDS An11g08650 4985085 complement(join(2045667..2049077,2049140..2049291,2049365..2049407,2049465..2049521)) VII 1 NT_166526.1 Function: the NAM7/UPF1 gene suppresses mitochondrial splicing deficiency when present in multiple copies.; Remark: the NAM7 protein of S. cerevisiae contains several motifs typical for proteins interacting with nucleic acids: (1) five motifs diagnostic for a superfamily of helicases appear in the same order and with similar distances; (2) the N-terminal portion possesses potential Zn-ligand structures belonging to the C chi superfamily.; Similarity: the predicted A. niger protein shows similarity to prematurely terminated mRNA decay factor NAM7 (UPF1) of S. cerevisiae and to several putative DNA helicase like proteins.; Title: similarity to prematurely terminated mRNA decay factor Nam7 - Saccharomyces cerevisiae; See PMID 7506349; See PMID 9199511; uncharacterized protein 2049521 4985085 An11g08650 Aspergillus niger uncharacterized protein XP_059604369.1 2045667 R 5061 CDS An11g08670 10098098 complement(2051087..2055499) VII 1 NT_166526.1 Title: strong similarity to retrotransposon Tto1 -Nicotiana tabacum; See PMID 8624443; uncharacterized protein 2055499 10098098 An11g08670 Aspergillus niger uncharacterized protein XP_003188848.2 2051087 R 5061 CDS An11g08700 84592389 complement(join(2058587..2059053,2059112..2059314,2059370..2059373,2059409..2059462,2059492..2060107)) VII 1 NT_166526.1 Title: strong similarity to rhamnogalacturonase rhgA - Aspergillus aculeatus [putative frameshift]; putative frameshift; uncharacterized protein 2060107 84592389 An11g08700 Aspergillus niger uncharacterized protein XP_059604370.1 2058587 R 5061 CDS An11g08710 84592390 join(2062668..2062727,2062780..2063838) VII 1 NT_166526.1 hypothetical protein 2063838 84592390 An11g08710 Aspergillus niger hypothetical protein XP_059604371.1 2062668 D 5061 CDS An11g08720 84592391 2065159..2066412 VII 1 NT_166526.1 Title: weak similarity to hypothetical protein encoded by An15g02550 - Aspergillus niger; uncharacterized protein 2066412 84592391 An11g08720 Aspergillus niger uncharacterized protein XP_059604372.1 2065159 D 5061 CDS An11g08730 84592392 complement(join(2066766..2066891,2066926..2067486)) VII 1 NT_166526.1 Title: similarity to hypothetical protein encoded by An09g01180 - Aspergillus niger; uncharacterized protein 2067486 84592392 An11g08730 Aspergillus niger uncharacterized protein XP_059604373.1 2066766 R 5061 CDS An11g08740 84592393 complement(join(2069343..2069438,2069620..2069622)) VII 1 NT_166526.1 hypothetical protein 2069622 84592393 An11g08740 Aspergillus niger hypothetical protein XP_059604374.1 2069343 R 5061 CDS An11g08750 4985092 complement(2070993..2071445) VII 1 NT_166526.1 Remark: rfbM acts sequentially with phosphomannomutase to form GDP-mannose, which serves as the activated sugar nucleotide precursor for mannose residues in cell surface and capsular polysaccharides in Escherichia coli.; Title: weak similarity to GDP-mannose pyrophosphorylase rfbM - Escherichia coli; See PMID 7515042; uncharacterized protein 2071445 4985092 An11g08750 Aspergillus niger uncharacterized protein XP_001394836.1 2070993 R 5061 CDS An11g08760 4985094 complement(2071781..>2073319) VII 1 NT_166526.1 Remark: truncated due to contig end.; hypothetical protein [truncated ORF] 2073319 4985094 An11g08760 Aspergillus niger hypothetical protein [truncated ORF] XP_059604375.1 2071781 R 5061 CDS An11g08770 84592394 complement(join(<2073420..2076988,2077269..>2077279)) VII 1 NT_166526.1 Title: similarity to hypothetical agglutinin-like protein - Candida albicans; uncharacterized protein 2077279 84592394 An11g08770 Aspergillus niger uncharacterized protein XP_059606368.1 2073420 R 5061 CDS An11g08780 4985095 complement(join(2079726..2080242,2080320..2080543)) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein AAP25659.1 - Bacillus anthracis; uncharacterized protein 2080543 4985095 An11g08780 Aspergillus niger uncharacterized protein XP_059606369.1 2079726 R 5061 CDS An11g08790 4985096 2081709..2082443 VII 1 NT_166526.1 Title: similarity to hypothetical protein yukJ -Bacillus subtilis; uncharacterized protein 2082443 4985096 An11g08790 Aspergillus niger uncharacterized protein XP_001394840.1 2081709 D 5061 CDS An11g08810 4985098 join(2083927..2084146,2084180..2084425,2084472..2084540,2084599..2085198,2085331..2085755) VII 1 NT_166526.1 Function: gibberlin synthesis in G. fujikuroi involves at least four cytochrome P450 monooxygenase-catalyzed steps and at least three P450 monooxygenases are involved one of them beeing P450I.; Title: strong similarity to cytochrome P450 monooxygenase P450I - Gibberella fujikuroi; See PMID 9501474; See PMID 9917370; See PMID 10531641; uncharacterized protein 2085755 4985098 An11g08810 Aspergillus niger uncharacterized protein XP_059606370.1 2083927 D 5061 CDS An11g08820 4985099 join(2086290..2086331,2086460..2086653,2086725..2087415,2087485..2087644,2087703..2088013,2088077..2088271,2088358..2088402) VII 1 NT_166526.1 Function: methionine is transported into yeast cells by three different permeases, a high affinity (MUP1) and two low affinity permeases.; Remark: S. cerevisiae MUP1 was shown to encode an integral membrane protein with 13 putative membrane-spanning regions.; Title: strong similarity to high affinity methionine permease Mup1 - Saccharomyces cerevisiae; plasma membrane; See PMID 8893857; uncharacterized protein 2088402 4985099 An11g08820 Aspergillus niger uncharacterized protein XP_001394842.3 2086290 D 5061 CDS An11g08830 4985100 complement(join(2088618..2088937,2089007..2089263,2089351..2090591,2090636..2090647)) VII 1 NT_166526.1 Remark: an alternative name for Magnaporthe grisea is Pyricularia grisea.; Similarity: similarity is between the fungal Gal4 type Zn(2)-Cys(6) DNA-binding domains in the N-terminal region of the predicted A. niger protein and M. grisea PIG1.; Title: weak similarity to transcription factor PIG1 - Magnaporthe grisea; nucleus; See PMID 11123670; uncharacterized protein 2090647 4985100 An11g08830 Aspergillus niger uncharacterized protein XP_059606371.1 2088618 R 5061 CDS An11g08840 4985101 join(2091209..2091215,2091256..2091457,2091512..2091962) VII 1 NT_166526.1 Title: strong similarity to 19.3 kD subunit of NADH:ubiquinone reductase PSST - Bos taurus; localisation:mitochondrion; uncharacterized protein 2091962 4985101 An11g08840 Aspergillus niger uncharacterized protein XP_001394844.3 2091209 D 5061 CDS An11g08850 84592395 join(2092901..2093122,2093185..2093779,2093853..2094052) VII 1 NT_166526.1 Function: S. scrofa RGD-CAP enhances the spreading of chondrocytes and fibroblasts via integrin alpha(1)beta(1), which does not require binding to the RGD domain.; Function: the RGD sequence of S. scrofa RGD-CAP may serve as a recognition sequence for integrins.; Similarity: S. scrofa RGD-CAP is a fasciclin-like adhesion protein and the predicted A. niger protein contains a fasciclin domain.; Title: weak similarity to collagen fiber-associated protein RGD-CAP - Sus scrofa; See PMID 9061001; See PMID 9512662; See PMID 10446401; uncharacterized protein 2094052 84592395 An11g08850 Aspergillus niger uncharacterized protein XP_059606372.1 2092901 D 5061 CDS An11g08860 4985103 complement(join(2094711..2094807,2094871..2095158,2095216..2095316)) VII 1 NT_166526.1 Title: strong similarity to EST o0f12a1.r1 -Aspergillus nidulans; uncharacterized protein 2095316 4985103 An11g08860 Aspergillus niger uncharacterized protein XP_001394846.1 2094711 R 5061 CDS An11g08870 4985104 join(<2096985..2097455,2097520..2098221,2098286..2098402) VII 1 NT_166526.1 Catalytic activity: ornithine transaminase convert L-ornithine + a 2-oxo acid to L-glutamate 5-semialdehyde + an L-amino acid.; Function: A. nidulans otaA is involved in arginine catabolism and nitrogen utilisation.; Induction: expression of A. nidulans otaA is specifically induced by arginine.; Regulation: regulation of A. nidulans otaA occurs at both transcriptional and post-transcriptional levels.; Repression: expression of A. nidulans otaA is under the control of nitrogen-metabolite and carbon-catabolite repression.; Title: strong similarity to ornithine transaminase otaA - Aspergillus nidulans; See PMID 10079330; uncharacterized protein 2098402 4985104 An11g08870 Aspergillus niger uncharacterized protein XP_001394847.1 2096985 D 5061 CDS An11g08880 4985105 complement(join(2098856..2098904,2098948..2100051,2100126..2100529,2100582..2100620)) VII 1 NT_166526.1 Similarity: S. cerevisiae DAL5 specifies the Dal5p subfamily of the major facilitator family, which also includes YGR260w and YLR004c.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 3275614; See PMID 10869563; uncharacterized protein 2100620 4985105 An11g08880 Aspergillus niger uncharacterized protein XP_001394848.3 2098856 R 5061 CDS An11g08890 4985106 complement(join(2101023..2101746,2101828..2102210,2102284..2102370)) VII 1 NT_166526.1 Function: S. aureus hmrA conferred Eagle-type resistance, i. e. resistance to high concentrations of methicillin (64 to 512 microg/ml) and susceptibility to low concentrations of methicillin (2 to 16 microg/ml), when introduced into the cell in multiple copies.; Similarity: the predicted A. niger protein shows similarity to several putative hydrolase proteins and contains a hydrolase BLOCKs motif.; Title: strong similarity to methicillin resistance gene HmrA - Staphylococcus aureus; See PMID 11181367; uncharacterized protein 2102370 4985106 An11g08890 Aspergillus niger uncharacterized protein XP_059606373.1 2101023 R 5061 CDS An11g08900 4985107 join(2102851..2104254,2104355..2104439,2104489..2104610) VII 1 NT_166526.1 Function: A. nidulans amdS hydrolyses acetamide to acetate and ammonium thus providing a source of carbon and nitrogen.; Regulation: regulation of A. nidulans amdS is complex and involves multiple regulatory transcription factors like amdR and amdX.; Title: strong similarity to acetamidase amdS -Aspergillus nidulans; See PMID 3036667; See PMID 7847883; See PMID 9044292; uncharacterized protein 2104610 4985107 An11g08900 Aspergillus niger uncharacterized protein XP_001394850.1 2102851 D 5061 CDS An11g08910 84592396 complement(join(2104746..2105606,2105657..2106249,2106329..2106413)) VII 1 NT_166526.1 Similarity: the ORF encoded protein shows weak similarities to many fungal Zn(2)-Cys(6) binuclear type transcription factors. The similarity of the ORF encoded protein to Lys14 concerns only the DNA binding domain with the binuclear zinc cluster.; Title: weak similarity to transcription activator of lysine pathway Lys14 - Saccharomyces cerevisiae; uncharacterized protein 2106413 84592396 An11g08910 Aspergillus niger uncharacterized protein XP_059606374.1 2104746 R 5061 CDS An11g08920 4985109 complement(join(2107211..2110392,2110440..2111379)) VII 1 NT_166526.1 Remark: the HET-E gene of the fungus Podospora anserina is responsible for vegetative incompatibility.; Similarity: the c-terminal part of the ORF encoded protein shows similarity to many ankyrins and ankyrin homologs.; Title: similarity to beta-transducin-like protein het-e - Podospora anserina; See PMID 7557402; See PMID 9435787; uncharacterized protein 2111379 4985109 An11g08920 Aspergillus niger uncharacterized protein XP_001394852.1 2107211 R 5061 CDS An11g08930 4985110 join(2113364..2113432,2113487..2113687,2113741..2113881,2113995..2114407,2114462..2115402,2115458..2115696) VII 1 NT_166526.1 Function: nirA of A. nidulans is a zinc finger transcription factor mediating nitrate induction of genes involved in nitrate assimilation (nitrate reductase,nitrite reductases and a nitrate permease, niaD, niiA and crnA, respectively).; Remark: the ORF encoded protein and nirA from A. nidulans are fungal Zn(2)-Cys(6) binuclear type transcription factors.; Remark: the nitrate assimilation genes are induced by nitrate and repressed by ammonium at the transcriptional level.; Title: similarity to nitrate assimilation regulatory protein nirA - Aspergillus nidulans; nucleus; See PMID 1990284; uncharacterized protein 2115696 4985110 An11g08930 Aspergillus niger uncharacterized protein XP_059606375.1 2113364 D 5061 CDS An11g08940 4985111 complement(join(2115998..2116122,2116172..2116353,2116430..2116536,2116597..2116817,2116891..2116966)) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein YDR533c - Saccharomyces cerevisiae; uncharacterized protein 2116966 4985111 An11g08940 Aspergillus niger uncharacterized protein XP_059606376.1 2115998 R 5061 CDS An11g08950 4985112 join(2118753..2118774,2118841..2119107,2119163..2119254,2119303..2119926) VII 1 NT_166526.1 Similarity: the ORF encoded protein shows also strong similarity (e-val. : 2e-59) to the stress induced human oxidoreductase PIG3 (p53-inducible gene 3; Pubmed 11158615) of unknown function. It also shows strong similarity (e-val. : 5e-31) to the actVI-ORF2 oxidoreductase from Streptomyces coelicolor involved in actinorhodin biosynthesis (Pubmed 10805574).; Title: strong similarity to oxidoreductase protein HORP-4 from patent WO200000622-A2 - Homo sapiens; uncharacterized protein 2119926 4985112 An11g08950 Aspergillus niger uncharacterized protein XP_001394855.3 2118753 D 5061 CDS An11g08960 84592397 complement(join(2120461..2120674,2120788..2120877,2120928..2121016)) VII 1 NT_166526.1 Title: weak similarity to Sucrose-phosphate-synthase from patent DE4317596-A - Beta vulgaris; uncharacterized protein 2121016 84592397 An11g08960 Aspergillus niger uncharacterized protein XP_059606377.1 2120461 R 5061 CDS An11g08970 84592398 join(2123410..2123677,2123960..2124243) VII 1 NT_166526.1 hypothetical protein 2124243 84592398 An11g08970 Aspergillus niger hypothetical protein XP_059606378.1 2123410 D 5061 CDS An11g08980 84592399 join(2126031..2126948,2126982..2127980) VII 1 NT_166526.1 Remark: Fugu rubripes=Japanese pufferfish.; Similarity: the ORF encoded protein shows also weak similarity to the D2-like dopamine receptor from Fugu rubripes.; Title: weak similarity to hypothetical protein CAD70538.1 - Neurospora crassa; uncharacterized protein 2127980 84592399 An11g08980 Aspergillus niger uncharacterized protein XP_059606379.1 2126031 D 5061 CDS An11g08990 4985116 complement(join(2128614..2128649,2128801..2129726,2129795..2129948,2130002..2130517)) VII 1 NT_166526.1 Function: When the S. cerevisiae TPO1/YLL028w gene was disrupted by inserting the HIS3 gene, the cells became sensitive to polyamines, and spermine uptake activity of isolated vacuolar membrane vesicles decreased significantly.; Remark: alternate name for S. cerevisiae Tpo1: YLL028w.; Similarity: the ORF encoded protein shows stonger similarity to the protein involved in cephalosporin C biosynthesis described in patent JP09009966-A, but the patent does not describe its function precisely enough.; Title: strong similarity to polyamine transport protein Tpo1 - Saccharomyces cerevisiae; vacuole; See PMID 9920864; uncharacterized protein 2130517 4985116 An11g08990 Aspergillus niger uncharacterized protein XP_001394859.3 2128614 R 5061 CDS An11g09000 4985117 2132709..2133368 VII 1 NT_166526.1 Catalytic activity: RX + glutathione <=> HX + R-S-glutathione.; Function: the GST from E. coli catalyzes the conjugation of glutathione to a large variety of electrophilic compounds of endobiotic and xenobiotic origin. It is also involved in intracellular binding and transport of hydrophobic compounds and involved in detoxification of organic hydroperoxides.; Title: strong similarity to glutathione transferase GST - Escherichia coli; See PMID 7798255; uncharacterized protein 2133368 4985117 An11g09000 Aspergillus niger uncharacterized protein XP_001394860.1 2132709 D 5061 CDS An11g09010 4985118 join(2134973..2135345,2135769..2135924,2135983..2136749) VII 1 NT_166526.1 Similarity: the rat choline kinase R2 is identical to the protein described in patent JP05015367-A.; Title: weak similarity to choline kinase R2 CK-R2 -Rattus norvegicus; uncharacterized protein 2136749 4985118 An11g09010 Aspergillus niger uncharacterized protein XP_059606380.1 2134973 D 5061 CDS An11g09020 84592400 join(2138546..2138615,2138845..2138894,2139046..2139349,2139606..2139781) VII 1 NT_166526.1 hypothetical protein 2139781 84592400 An11g09020 Aspergillus niger hypothetical protein XP_059606381.1 2138546 D 5061 CDS An11g09030 4985120 complement(join(2140061..2140751,2140806..2141709,2141775..2141847)) VII 1 NT_166526.1 Catalytic activity: UDP-glucuronate + acceptor <=> UDP + acceptor beta-D-glucuronoside.; Function: the rat UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. It is also active on testosterone.; Remark: alternate names for the rat UDPGT : RLUG38 or UGT2B3.; Title: similarity to UDP-glucuronosyltransferase 3 precursor UDPGT - Rattus norvegicus; See PMID 3110162; See PMID 7492328; uncharacterized protein 2141847 4985120 An11g09030 Aspergillus niger uncharacterized protein XP_001394863.1 2140061 R 5061 CDS An11g09040 4985121 complement(join(2142875..2143601,2143650..2143771,2143850..2144011)) VII 1 NT_166526.1 hypothetical protein 2144011 4985121 An11g09040 Aspergillus niger hypothetical protein XP_059606382.1 2142875 R 5061 CDS An11g09050 4985122 complement(join(2146112..2146184,2146563..2146996)) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein encoded by An03g06750 - Aspergillus niger; uncharacterized protein 2146996 4985122 An11g09050 Aspergillus niger uncharacterized protein XP_001394865.3 2146112 R 5061 CDS An11g09060 4985123 join(2147592..2147874,2147925..2148847) VII 1 NT_166526.1 Title: weak similarity to bacteriophage resistance mechanism subunit HsdR from patent FR2767831-A1 -Lactococcus lactis; uncharacterized protein 2148847 4985123 An11g09060 Aspergillus niger uncharacterized protein XP_001394866.1 2147592 D 5061 CDS An11g09080 4985124 complement(join(2149633..2150427,2150488..2150851,2150962..2151113)) VII 1 NT_166526.1 Catalytic activity: (R)-6-hydroxynicotine + H(2)O + O(2) <=> 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H(2)O(2).; Cofactor: FAD.; Similarity: the ORF encoded protein shows similarity to many hypothetical flavoprotein oxidoreductases. The similarity of the ORF encoded protein to the 6-hydroxy-D-nicotine oxidase 6-HDNO from A. oxidans only concerns the N-terminal protein part. Even the similarity to the MmcM product from S. lavendulae is more extended,but this enzyme involved in the mitomycin C from Streptomyces lavendulae is biochemically not enough characterized.; Title: similarity to 6-hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 3622516; See PMID 2115879; See PMID 2680607; uncharacterized protein 2151113 4985124 An11g09080 Aspergillus niger uncharacterized protein XP_059606383.1 2149633 R 5061 CDS An11g09090 84592401 join(2151762..2151985,2152056..2152145,2152242..2152488,2152527..2152625,2152703..2152717) VII 1 NT_166526.1 hypothetical protein 2152717 84592401 An11g09090 Aspergillus niger hypothetical protein XP_059606384.1 2151762 D 5061 CDS An11g09110 4985127 complement(join(2153969..2155137,2155192..2155477)) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein B12F1.100 - Neurospora crassa; uncharacterized protein 2155477 4985127 An11g09110 Aspergillus niger uncharacterized protein XP_001394869.1 2153969 R 5061 CDS An11g09120 4985128 complement(join(2156145..2156384,2156442..2156474,2156716..2156828,2156907..2156925)) VII 1 NT_166526.1 Remark: alternate names for cytosolic ribosomal protein L26 from S. cerevisiae: RPL26B or YGR034W.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L26 - Saccharomyces cerevisiae; cytoplasm; See PMID 9672752; See PMID 1733947; 60S ribosomal protein uL24 2156925 4985128 An11g09120 Aspergillus niger 60S ribosomal protein uL24 XP_001394870.1 2156145 R 5061 CDS An11g09130 4985129 complement(2158092..2159912) VII 1 NT_166526.1 Remark: alternate name for S. cerevisiae Flr1: YBR008c.; Similarity: the ORF encoded protein also shows stong similarity to the protein involved in cephalosporin C biosynthesis described in patent JP09009966-A.; Title: strong similarity to fluconazole resistance transporter Flr1 - Saccharomyces cerevisiae; See PMID 9235926; See PMID 10572257; uncharacterized protein 2159912 4985129 An11g09130 Aspergillus niger uncharacterized protein XP_001394871.1 2158092 R 5061 CDS An11g09140 4985130 join(2161376..2161742,2161800..2162680,2162737..2163063) VII 1 NT_166526.1 Remark: the Flu1 gene product from C. albicans complements the fluconazole hypersusceptibility of a S. cerevisiae pdr5 mutant, lacking the ABC (ATP-binding cassette) transporter gene PDR5.; Similarity: the ORF encoded protein shows stonger similarity to the protein involved in cephalosporin C biosynthesis described in patent JP09009966-A, but the patent does not describe its function precisely enough.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; plasma membrane; See PMID 11065353; uncharacterized protein 2163063 4985130 An11g09140 Aspergillus niger uncharacterized protein XP_001394872.1 2161376 D 5061 CDS An11g09150 4985131 join(2163597..2163757,2163807..2164475,2164528..2164722,2164802..2165009,2165108..2165752) VII 1 NT_166526.1 Similarity: Gal4 from S. cerevisiae belongs to the fungal binuclear zinc cluster transcription factor family.; Title: weak similarity to transcription factor Gal4 - Saccharomyces cerevisiae; See PMID 1557122; uncharacterized protein 2165752 4985131 An11g09150 Aspergillus niger uncharacterized protein XP_059606385.1 2163597 D 5061 CDS An11g09160 84592402 complement(join(2166059..2166332,2166369..2167174)) VII 1 NT_166526.1 Remark: the deletion Emericella nidulans aflR gene results in an inability to induce expression of genes within the ST (sterigmatocystin) gene cluster and a loss of ST production. Sterigmatocystin is a carcinogenic secondary metabolite related to aflatoxin.; Similarity: the ORF encoded protein shows also similarity to the AflR homologs from Aspergillus parasiticus and Aspergillus flavus.; Similarity: the ORF encoded protein, the AflR protein from Emericella nidulans and its homologs are transcriptional regulators of the fungal binuclear zinc cluster type.; Title: similarity to sterigmatocystin synthesis transcription regulator aflR - Aspergillus nidulans; See PMID 8662194; uncharacterized protein 2167174 84592402 An11g09160 Aspergillus niger uncharacterized protein XP_059606386.1 2166059 R 5061 CDS An11g09170 4985133 complement(join(2167981..2168897,2168967..2169273,2169335..2169511)) VII 1 NT_166526.1 Catalytic activity: the SAP8 protease from C. albicans preferential cleaves at the carboxyl end of hydrophobic amino acids, but fails to cleave 15-Leu-Tyr-16,16-Tyr-Leu-17 and 24-Phe-Phe-25 of insulin beta chain. It activates trypsinogen, and degrades keratin.; Remark: alternate names for C. albicans SAP8: ACP 8,aspartate protease 8 or secreted aspartic protease 8.; Similarity: the SAP8 protease from C. albicans belongs to peptidase family A1; also known as the eukaryotic aspartyl proteases family.; Title: similarity to secreted aspartic proteinase SAP8 - Candida albicans; extracellular/secretion proteins; See PMID 9802014; uncharacterized protein 2169511 4985133 An11g09170 Aspergillus niger uncharacterized protein XP_001394875.1 2167981 R 5061 CDS An11g09180 84592403 2170508..2172685 VII 1 NT_166526.1 Remark: mutations in tol (N. crassa) are recessive and suppress mating-type-associated heterokaryon incompatibility.; Similarity: the similarity of the ORF encoded protein to the N. crassa tol protein does not extend over the complete length.; Title: similarity to mediator of mating-type-associated vegetative incompatibility tol -Neurospora crassa; See PMID 9927450; uncharacterized protein 2172685 84592403 An11g09180 Aspergillus niger uncharacterized protein XP_059606387.1 2170508 D 5061 CDS An11g09190 4985135 complement(2173067..2174125) VII 1 NT_166526.1 Title: weak similarity to hypothetical stress response protein rds1p - Schizosaccharomyces pombe; See PMID 7565608; uncharacterized protein 2174125 4985135 An11g09190 Aspergillus niger uncharacterized protein XP_001394877.1 2173067 R 5061 CDS An11g09200 4985136 join(2174997..2175277,2175340..2175438,2175491..2175866) VII 1 NT_166526.1 Similarity: the ORF encoded protein shows also weak similarity to the hypothetical protein F7O12 from Arabidopsis thaliana.; Title: weak similarity to hypothetical protein encoded by An04g04070 - Aspergillus niger; uncharacterized protein 2175866 4985136 An11g09200 Aspergillus niger uncharacterized protein XP_001394878.1 2174997 D 5061 CDS An11g09210 4985137 complement(join(2176268..2177188,2177281..2177424,2177478..2178017,2178282..2178467)) VII 1 NT_166526.1 Title: similarity to hypothetical negative acting factor related protein B3E4.130 - Neurospora crassa; uncharacterized protein 2178467 4985137 An11g09210 Aspergillus niger uncharacterized protein XP_059606388.1 2176268 R 5061 CDS An11g09220 4985138 complement(join(2179624..2180219,2180345..2180963)) VII 1 NT_166526.1 hypothetical protein 2180963 4985138 An11g09220 Aspergillus niger hypothetical protein XP_059606389.1 2179624 R 5061 CDS An11g09230 4985139 complement(join(2181561..2181647,2181833..2182305,2182359..2182578)) VII 1 NT_166526.1 Catalytic activity: Urea <=> cyanamide + H(2)O.; Cofactor: Zinc.; Remark: the cyanamide hydratase from Myrothecium verrucaria is also decribed in patent WO9848023-A1.; Title: strong similarity to cyanamide hydratase -Myrothecium verrucaria; See PMID 2034671; uncharacterized protein 2182578 4985139 An11g09230 Aspergillus niger uncharacterized protein XP_001394881.3 2181561 R 5061 CDS An11g09240 4985140 complement(2183179..2184810) VII 1 NT_166526.1 Catalytic activity: the Yps1 protease form S. cerevisiae hydrolyzes various precursor proteins with Arg or Lys in position 1(p1), and commonly Arg or Lys also in position 2(p2). The position 3(p3) amino acid is usually non-polar, but otherwise additional basic amino acids are favourable in both non-prime and prime positions.; Function: the Yps1 protease form S. cerevisiae cleaves at paired basic residues. It can process the alpha-mating factor precursor.; Remark: alternate names for S. cerevisiae Yps1: YLR120C or Yapsin 1 or aspergillopepsin. Yap3 is confusing because it is also a name for a transcription factor in S. cerevisiae.; Similarity: the Yps1 protease form S. cerevisiae belongs to peptidase family A1; also known as the eukaryotic aspartyl proteases family.; Title: similarity to Gpi-anchored aspartic protease Yps1 - Saccharomyces cerevisiae; See PMID 8389368; See PMID 9485427; uncharacterized protein 2184810 4985140 An11g09240 Aspergillus niger uncharacterized protein XP_001394882.1 2183179 R 5061 CDS An11g09250 4985141 complement(2186554..2187672) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein encoded by An11g05630 - Aspergillus niger; uncharacterized protein 2187672 4985141 An11g09250 Aspergillus niger uncharacterized protein XP_001394883.1 2186554 R 5061 CDS An11g09260 4985142 join(2189042..2189299,2189358..2189643,2189694..2189848,2189986..2190367,2190423..2190895) VII 1 NT_166526.1 Remark: alternate names for the rat mitochondrial vitamin D3 25-monooxygenase cytochrome P450 27 precursor: cholesterol 26-hydroxylase; cytochrome P450 CYP27; cytochrome P450c26/25; cytochrome P450mt3,phenobarbital-inducible; vitamin D3 25-hydroxylase.; Similarity: the ORF encoded protein is only similar to the C-terminal part of the rat vitamin D3 25-monooxygenase a part which is conserved in most p450 enzyms. Both proteins are only distantly related, so a functional prediction is impossible. The ORF encoded protein shows (very) strong similarity to the unknown p450-4 enzym from Gibberella fujikuroi.; Title: similarity to precursor of mitochondrial vitamin D3 25-monooxygenase cytochrome P450 - Rattus norvegicus; See PMID 2175615; uncharacterized protein 2190895 4985142 An11g09260 Aspergillus niger uncharacterized protein XP_059606390.1 2189042 D 5061 CDS An11g09270 4985143 complement(join(2191128..2192318,2192369..2192580,2192631..2192949)) VII 1 NT_166526.1 Catalytic activity: 2,3-dihydroxy-3-methylbutanoate <=> 3-methyl-2-oxobutanoate + H(2)O.; Pathway: the dihydroxy-acid dehydratase from Zea mays catalyzes the fourth step in valine and isoleucine biosynthesis.; Similarity: the ORF encoded protein shows also strong similarity to the known dihydroxy-acid dehydratases Ilv3 (S. cerevisiae Pubmed 8299945) and IlvD (B. subtilis).; Title: strong similarity to dihydroxy-acid dehydratase from patent WO9921880-A2 - Zea mays; uncharacterized protein 2192949 4985143 An11g09270 Aspergillus niger uncharacterized protein XP_001394885.1 2191128 R 5061 CDS An11g09280 84592404 join(<2200433..2200435,2200644..2200704,2200752..2200782,2200996..2201116) VII 1 NT_166526.1 Remark: ORF 5'truncated due to end of contig.; hypothetical protein [truncated ORF] 2201116 84592404 An11g09280 Aspergillus niger hypothetical protein [truncated ORF] XP_059599541.1 2200433 D 5061 CDS An11g09290 84592405 join(2203902..2204272,2204743..2204846,2205023..2205074,2205240..2205312) VII 1 NT_166526.1 hypothetical protein 2205312 84592405 An11g09290 Aspergillus niger hypothetical protein XP_059599542.1 2203902 D 5061 CDS An11g09300 84592406 complement(<2205970..2206618) VII 1 NT_166526.1 Remark: ORF 3'truncated due to end of contig.; hypothetical protein [truncated ORF] 2206618 84592406 An11g09300 Aspergillus niger hypothetical protein [truncated ORF] XP_059601664.1 2205970 R 5061 CDS An11g09310 4985147 complement(join(2207783..2209899,2209984..2210050)) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein SPBC337.17c - Schizosaccharomyces pombe; uncharacterized protein 2210050 4985147 An11g09310 Aspergillus niger uncharacterized protein XP_059601665.1 2207783 R 5061 CDS An11g09320 4985148 complement(join(2210412..2210895,2210972..2211203,2211257..2211298,2211346..2211459,2211516..2211558,2211611..2211755,2211841..2211968,2212049..2212219)) VII 1 NT_166526.1 Catalytic activity: uridine kinase convert ATP + Uridine to ADP + UMP.; Function: S. cerevisiae urk1 phosphorylates Cytidine into CMP.; Title: strong similarity to uridine kinase Urk1 -Saccharomyces cerevisiae; See PMID 7900425; See PMID 10501935; See PMID 2169608; uncharacterized protein 2212219 4985148 An11g09320 Aspergillus niger uncharacterized protein XP_001394890.1 2210412 R 5061 CDS An11g09330 4985149 join(2212713..2212730,2212789..2212865,2213057..2213252,2213458..2213985) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein F11P17.12 - Arabidopsis thaliana; uncharacterized protein 2213985 4985149 An11g09330 Aspergillus niger uncharacterized protein XP_001394891.1 2212713 D 5061 CDS An11g09340 4985150 complement(join(2214935..2215531,2216028..2216036)) VII 1 NT_166526.1 Similarity: the ORF encoded protein shows also weak similarity to hypothetical protein Rv0976c from Mycobacterium tuberculosis.; Title: similarity to hypothetical protein Rv0976c -Mycobacterium tuberculosis; uncharacterized protein 2216036 4985150 An11g09340 Aspergillus niger uncharacterized protein XP_059601666.1 2214935 R 5061 CDS An11g09350 4985151 complement(join(2219179..2219240,2219509..2220240,2220297..2220447,2220509..2220849,2220918..2221734)) VII 1 NT_166526.1 Catalytic activity: NADH dehydrogenases convert NADH + ubiquinone to NAD(+) + ubiquinol.; Localization: N. crassa ndh64 is located in the inner membrane of mitochondria, possibly facing the matrix side.; Similarity: N. crassa ndh64 shows strong similarity to mitochondrial NADH dehydrogenases from yeast, however it contains a well-conserved calcium-binding domain.; Title: strong similarity to mitochondrial NADH dehydrogenase ndh64 - Neurospora crassa; localisation:mitochondrion; See PMID 10482790; uncharacterized protein 2221734 4985151 An11g09350 Aspergillus niger uncharacterized protein XP_059601667.1 2219179 R 5061 CDS An11g09360 4985152 complement(join(2222348..2225171,2225222..2227226,2227279..2227415,2227469..2227658,2227729..2227891)) VII 1 NT_166526.1 Function: C. cinereus rad9 acts as a sister chromatid cohesion molecule.; Function: the rad9 gene of C. cinereus encodes a proline-rich protein required for meiotic chromosome condensation and synapsis.; Title: similarity to proline-rich protein Rad9 -Coprinus cinereus; nucleus; See PMID 7753026; See PMID 8846891; uncharacterized protein 2227891 4985152 An11g09360 Aspergillus niger uncharacterized protein XP_001394894.1 2222348 R 5061 CDS An11g09370 4985153 join(2228281..2228395,2228472..2228703,2228777..2228795) VII 1 NT_166526.1 Catalytic activity: RNA polymerase I catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.; Function: A12. 2 plays a role in the assembly of A190, the largest subunit of RNA polymerase I, into a stable polymerase I structure.; Function: RNA polymerase I can initiate a chain de novo.; Function: S. cereviaisae RPA12 encodes the A12. 2 subunit of RNA polymerase I and is essential only at high temperatures.; Remark: alternate names for RPA12 of S. cerevisiae are A12. 2 or RRN4.; Title: strong similarity to 13.7 kD subunit of DNA-directed RNA polymerase I Rpa12 - Saccharomyces cerevisiae; nucleus; See PMID 8417319; See PMID 9121426; uncharacterized protein 2228795 4985153 An11g09370 Aspergillus niger uncharacterized protein XP_001394895.1 2228281 D 5061 CDS An11g09380 4985154 complement(join(2228904..2229429,2229504..2229994)) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein YJR070c - Saccharomyces cerevisiae; uncharacterized protein 2229994 4985154 An11g09380 Aspergillus niger uncharacterized protein XP_001394896.1 2228904 R 5061 CDS An11g09390 4985155 complement(join(2231358..2231667,2231734..2231844,2231906..2232144)) VII 1 NT_166526.1 Catalytic activity: NADH:ubiquinone oxidoreductase converts NADH + ubiquinone to NAD(+) + ubiquinol.; Title: strong similarity to 21 kD subunit of NADH:ubiquinone reductase nuo-21 - Neurospora crassa; localisation:mitochondrion; See PMID 7947902; uncharacterized protein 2232144 4985155 An11g09390 Aspergillus niger uncharacterized protein XP_001394897.1 2231358 R 5061 CDS An11g09400 4985156 join(2232473..2232520,2232582..2232596,2232730..2232880,2232910..2233190) VII 1 NT_166526.1 Complex: S. cerevisiae ATP17 is part of the hydrogen-transporting ATP synthase F0 sector (Subunit f of mitochondrial ATP synthase).; Function: S. cerevisiae ATP17 is a hydrogen-transporting two-sector ATPase and is involved in ATP synthesis coupled proton transport.; Remark: the systematic name for S. cerevisiae ATP17 is YDR377W.; Title: similarity to subunit f of mitochondrial yeast ATP synthase Atp17 - Saccharomyces cerevisiae; localisation:mitochondrion; uncharacterized protein 2233190 4985156 An11g09400 Aspergillus niger uncharacterized protein XP_059601668.1 2232473 D 5061 CDS An11g09410 4985157 complement(join(2234084..2234422,2234568..2235146)) VII 1 NT_166526.1 Title: similarity to hypothetical protein encoded by An15g02550 - Aspergillus niger; uncharacterized protein 2235146 4985157 An11g09410 Aspergillus niger uncharacterized protein XP_001394899.3 2234084 R 5061 CDS An11g09420 4985158 join(2236024..2236409,2236465..2236699,2236754..2236893,2236931..2237051,2237275..2237529) VII 1 NT_166526.1 Title: similarity to hypothetical protein encoded by An06g00740 - Aspergillus niger; uncharacterized protein 2237529 4985158 An11g09420 Aspergillus niger uncharacterized protein XP_059601669.1 2236024 D 5061 CDS An11g09430 84592407 join(2240619..2242632,2242688..2243169) VII 1 NT_166526.1 Remark: homology found is only based on repetitive sequence.; Title: weak similarity to hypothetical protein encoded by An03g01410 - Aspergillus niger; uncharacterized protein 2243169 84592407 An11g09430 Aspergillus niger uncharacterized protein XP_059601670.1 2240619 D 5061 CDS An11g09440 4985160 join(2243674..2243914,2244033..2244134,2244205..2244551,2244606..2244974,2245030..2245801,2245856..2246079) VII 1 NT_166526.1 Remark: Gene contains 5 WD repeats (trp-asp-domains) and belongs to the lec14B family of WD repeat proteins.; Remark: information concerning L. erythrorhizon LEC14B has not been published and is available from the Swissprot and EMBL databases.; Title: similarity to cDNA LEC14B - Lithospermum erythrorhizon; See PMID 10322433; uncharacterized protein 2246079 4985160 An11g09440 Aspergillus niger uncharacterized protein XP_001394902.1 2243674 D 5061 CDS An11g09450 4985161 join(2247525..2248000,2248066..2248679,2248732..2248850) VII 1 NT_166526.1 Title: weak similarity to hypothetical protein MDF20.11 - Arabidopsis thaliana; uncharacterized protein 2248850 4985161 An11g09450 Aspergillus niger uncharacterized protein XP_001394903.1 2247525 D 5061 CDS An11g09460 4985162 join(2249558..2249635,2249725..2250105) VII 1 NT_166526.1 Complex: using in vitro binding assays, S. cerevisiae Grd19p was found to interact physically with the cytosolic domain of DPAP A (dipeptidyl aminopeptidase A).; Function: S. cerevisiae GRD19 is involved in the process of retrieval of resident Golgi proteins from the prevacuolar compartment.; Function: S. cerevisiae Grd19p functions by direct interaction with the cytosolic tails of certain late-Golgi compartment membrane proteins during the sorting/budding process at the prevacuolar compartment.; Localization: S. cerevisiae Grd19p localises predominantly cytosolic.; Similarity: the predicted A. niger protein contains a PX (phox) domain which occurs in a variety of eucaryotic proteins associated with intracellular signaling pathways.; Title: strong similarity to component of the retrieval machinery Grd19 - Saccharomyces cerevisiae; cytoplasm; See PMID 9456318; uncharacterized protein 2250105 4985162 An11g09460 Aspergillus niger uncharacterized protein XP_001394904.3 2249558 D 5061 CDS An11g09470 4985163 complement(join(2250610..2251363,2251409..2251438,2251500..2252509)) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein EAA60367.1 - Aspergillus nidulans; uncharacterized protein 2252509 4985163 An11g09470 Aspergillus niger uncharacterized protein XP_001394905.1 2250610 R 5061 CDS An11g09480 4985164 join(2253249..2253313,2253366..2253799,2254360..2254448,2254481..2254537) VII 1 NT_166526.1 hypothetical protein 2254537 4985164 An11g09480 Aspergillus niger hypothetical protein XP_001394906.3 2253249 D 5061 CDS An11g09490 4985165 complement(join(2254800..2255111,2255167..2255586,2255711..2256328)) VII 1 NT_166526.1 Title: weak similarity to hypothetical protein encoded by An12g06920 - Aspergillus niger; uncharacterized protein 2256328 4985165 An11g09490 Aspergillus niger uncharacterized protein XP_059601671.1 2254800 R 5061 CDS An11g09500 4985166 complement(join(2262477..2262816,2262977..2263261,2263333..2263470,2263610..2263623)) VII 1 NT_166526.1 Function: ribosomal proteins S12, S5 and S4 of E. coli are essential for the control of translational accuracy and the yeast equivalents, S28, S4 and S13, have also been implicated in this process.; Remark: S. cerevisiae S4. e belongs to the small subunit (40s) of the ribosome.; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S4.e - Saccharomyces cerevisiae; cytoplasm; See PMID 6814480; See PMID 8950190; 40S ribosomal protein eS4 2263623 4985166 An11g09500 Aspergillus niger 40S ribosomal protein eS4 XP_001394908.1 2262477 R 5061 CDS An11g09510 4985167 complement(join(2263974..2264779,2264835..2265092,2265148..2265175)) VII 1 NT_166526.1 Catalytic activity: ASA DHs convert L-Aspartate 4-semialdehyde + Orthophosphate + NADP+ to L-4-Aspartyl phosphate + NADPH.; Complex: S. cerevisiae Hom2 forms a homodimer.; Function: S. cerevisiae HOM2 encodes an aspartic semi-aldehyde dehydrogenase (ASA DH).; Function: S. cerevisiae HOM2 is involved in the threonine/methionine biosynthetic pathway.; Induction: expression of S. cerevisiae HOM2 is weakly stimulated by methionine but shows no response to threonine.; Induction: induction of S. cerevisiae HOM2 expression is mediated by GCN4 and therefore by the general amino acid control.; Title: strong similarity to aspartate-semialdehyde dehydrogenase Hom2 - Saccharomyces cerevisiae; See PMID 1789001; See PMID 2570346; uncharacterized protein 2265175 4985167 An11g09510 Aspergillus niger uncharacterized protein XP_001394909.1 2263974 R 5061 CDS An11g09520 4985168 complement(join(2265846..2265998,2266054..2266235,2266283..2267336,2267424..2267762)) VII 1 NT_166526.1 Catalytic activity: D-lactate dehydrogenases convert (R)-Lactate + 2 Ferricytochrome c to Pyruvate + 2 Ferrocytochrome c.; Function: L- and D-lactate ferricytochrome c oxidoreductase (LCR) in yeast mitochondria catalyze the stereospecific oxidation of D and L isomers of lactate to pyruvate.; Function: oxidation of D-lactate is linked to the respiratory chain, cytochrome c being the electron acceptor of the redox reaction.; Title: strong similarity to D-lactate dehydrogenase dld - Kluyveromyces lactis; localisation:mitochondrion; See PMID 7969031; uncharacterized protein 2267762 4985168 An11g09520 Aspergillus niger uncharacterized protein XP_001394910.1 2265846 R 5061 CDS An11g09530 4985169 join(2268602..2268679,2268769..2268895,2268947..2269041,2269133..2269750,2269807..2269959,2270008..2271207,2271264..2271389,2271448..2271564,2271645..2272255,2272318..2272546) VII 1 NT_166526.1 Title: similarity to essential protein #23383 from patent WO200277183-A2 - Neisseria meningitidis; uncharacterized protein 2272546 4985169 An11g09530 Aspergillus niger uncharacterized protein XP_059601672.1 2268602 D 5061 CDS An11g09540 4985170 join(2273254..2273534,2273588..2273747,2273810..2274281,2274368..2277603) VII 1 NT_166526.1 Catalytic activity: RdRPs convert nucleoside triphosphate + RNA(n) to pyrophosphate + RNA(n+1).; Function: RdRPs are possibly involved in homology-dependent gene silencing.; Function: RdRPs catalyses RNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time.; Function: RdRPs function in post-transcriptional gene silencing.; Function: tomato RdRP can initiate a chain de novo.; Induction: expression of tomato RdRP is induced by viroid infection.; Title: strong similarity to RNA-directed RNA polymerase RdRP - Lycopersicon esculentum; See PMID 9836747; uncharacterized protein 2277603 4985170 An11g09540 Aspergillus niger uncharacterized protein XP_001394912.1 2273254 D 5061 CDS An11g09550 4985171 complement(join(2277692..2277695,2277964..2282731,2282791..2283025)) VII 1 NT_166526.1 Function: S. cerevisiae REV3 encodes the catalytic subunit of DNA polymerase (pol) zeta, which can replicate past certain types of DNA lesions.; Function: S. cerevisiae rev3 mutants are viable and have lower rates of spontaneous and DNA-damage-induced mutagenesis.; Title: strong similarity to DNA-directed DNA polymerase Rev3 - Saccharomyces cerevisiae; nucleus; See PMID 11050392; See PMID 2676986; uncharacterized protein 2283025 4985171 An11g09550 Aspergillus niger uncharacterized protein XP_001394913.3 2277692 R 5061 CDS An11g09560 4985172 2283395..2284828 VII 1 NT_166526.1 Function: human hSlu7 is required for a structural alteration of the spliceosome prior to the establishment of the catalytically active spliceosome for step II.; Function: yeast SLU7 is only required when the interval between the branchpoint and the 3' splice site is greater than 7 nt.; Function: yeast pre-mRNA splicing factors SLU7 and PRP16 are required for cleavage of the 3' splice site and exon ligation in vitro.; Title: similarity to pre-mRNA splicing factor hSLU7 - Homo sapiens; nucleus; See PMID 7568198; See PMID 7664739; See PMID 9153314; See PMID 10197984; See PMID 1427075; uncharacterized protein 2284828 4985172 An11g09560 Aspergillus niger uncharacterized protein XP_001394914.1 2283395 D 5061 CDS An11g09570 4985173 join(2285691..2285838,2285964..2286103) VII 1 NT_166526.1 Remark: 60S ribosomal protein.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L37.b - Saccharomyces cerevisiae; cytoplasm; See PMID 8082197; See PMID 1840541; 60S ribosomal protein eL37 2286103 4985173 An11g09570 Aspergillus niger 60S ribosomal protein eL37 XP_001394915.3 2285691 D 5061 CDS An11g09580 4985174 complement(join(2286695..2287021,2287094..2287576,2287726..2287989)) VII 1 NT_166526.1 Title: weak similarity to hypothetical protein YMR312w - Saccharomyces cerevisiae; uncharacterized protein 2287989 4985174 An11g09580 Aspergillus niger uncharacterized protein XP_059601673.1 2286695 R 5061 CDS An11g09590 4985175 join(2289432..2289464,2289523..2289552,2289603..2289697,2289785..2290101,2290159..2290850,2290916..2291391,2291460..2291832) VII 1 NT_166526.1 Remark: the Gal4 transcription factor is a positive regulator of the galactose-inducible genes in S. cerevisiae and is phosphorylated during interaction with the RNA polymerase II (Pol II) holoenzyme.; Title: similarity to transcription factor Gal4 -Saccharomyces cerevisiae; nucleus; See PMID 7601342; See PMID 10805731; See PMID 6366516; uncharacterized protein 2291832 4985175 An11g09590 Aspergillus niger uncharacterized protein XP_001394917.1 2289432 D 5061 CDS An11g09600 4985176 complement(join(2292077..2292564,2292608..2292985,2293048..2293138,2293203..2293648,2293702..2293747,2293808..2293872,2293935..2294075,2294144..2294288,2294351..2294428)) VII 1 NT_166526.1 Function: C. kessleri HUP2 also has strong similarity to the predicted A. niger protein and was shown to be a galactose-H+ symporter.; Remark: the properties of the mutant suggest that RCO3 is required for expression of glucose transport activity, glucose regulation of gene expression, and general carbon repression of development.; Title: strong similarity to glucose transporter rco-3 - Neurospora crassa; plasma membrane; See PMID 7870840; See PMID 9178001; uncharacterized protein 2294428 4985176 An11g09600 Aspergillus niger uncharacterized protein XP_059601674.1 2292077 R 5061 CDS An11g09610 4985177 complement(join(<2296039..2297193,2297239..2297299,2297354..2297512,2297578..2297621)) VII 1 NT_166526.1 Complex: subunits of the mammalian COP9 complex,include regulators of the Jun N-terminal kinase (JNK) and c-Jun, a nuclear hormone receptor binding protein (TRP19/COPS2) and a cell-cycle regulator.; Complex: the mammalian COP9 complex consists of eight subunits, six of them showing high similarity to six distinct non-ATPase regulatory subunits of the 26S proteasome.; Function: all of the subunits of the COP9 complex contain structural features that are also present in the components of the proteasome regulatory complex and the translation initiation factor eIF3 complex.; Function: human SNG2 is a component of the signalosome or COP9 protein complex.; Function: the signalosome complex is an important cellular regulator modulating multiple signaling pathways.; Localization: the signalosome complex is found in the cytoplasm and the nucleus.; Remark: ORF 3'truncated due to end of contig.; Title: strong similarity to signalosome subunit SGN2 - Homo sapiens [truncated ORF]; See PMID 10087198; See PMID 10585392; uncharacterized protein 2297621 4985177 An11g09610 Aspergillus niger uncharacterized protein XP_001394919.3 2296039 R 5061 CDS An11g09620 4985178 join(2298837..2298890,2298942..2299068,2299277..2299398,2299449..2299650,2299712..2299830) VII 1 NT_166526.1 Function: S. cerevisiae Rho3 acts as a key regulator of cell polarity and exocytosis independet of its function as actin organising protein.; Similarity: S. cerevisiae Rho3 is a GTP-binding protein of the rho family.; Title: strong similarity to GTPase Rho3 -Saccharomyces cerevisiae; See PMID 10588647; See PMID 10998597; uncharacterized protein 2299830 4985178 An11g09620 Aspergillus niger uncharacterized protein XP_059601675.1 2298837 D 5061 CDS An11g09630 4985179 complement(2300309..2301190) VII 1 NT_166526.1 Function: K. lactis LIPB creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoate-dependent enzymes.; Title: strong similarity to lipoyl-protein ligase LIPB - Kluyveromyces lactis; localisation:mitochondrion; See PMID 9268025; uncharacterized protein 2301190 4985179 An11g09630 Aspergillus niger uncharacterized protein XP_059601676.1 2300309 R 5061 CDS An11g09640 4985180 complement(join(2301718..2302329,2302398..2302514)) VII 1 NT_166526.1 Title: strong similarity to hypothetical GTPase activating protein homolog GAP1 - Cochliobolus heterostrophus; uncharacterized protein 2302514 4985180 An11g09640 Aspergillus niger uncharacterized protein XP_001394922.1 2301718 R 5061 CDS An11g09650 4985181 join(2303982..2304231,2304361..2304657,2304741..2305225) VII 1 NT_166526.1 Title: similarity to hypothetical protein NIPSNAP1 -Danio rerio; uncharacterized protein 2305225 4985181 An11g09650 Aspergillus niger uncharacterized protein XP_059601677.1 2303982 D 5061 CDS An11g09660 4985182 join(2306561..2306700,2306782..2306791,2306855..2307012,2307094..2307140,2307206..2307301,2307358..2308022,2308072..2308182) VII 1 NT_166526.1 Catalytic activity: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine.; Catalytic activity: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine.; Remark: EPT1 requires a divalent cation activator,and is inhibited by CMP in S. cerevisiae.; Remark: The multiple transmembrane domains and lumenal hydrophilic domains of the EPT1 might participate in the transport process in S. cerevisiae.; Title: strong similarity to ethanolaminephosphotransferase Ept1 - Saccharomyces cerevisiae; plasma membrane; See PMID 1847919; uncharacterized protein 2308182 4985182 An11g09660 Aspergillus niger uncharacterized protein XP_001394924.1 2306561 D 5061 CDS An11g09670 4985183 join(2308863..2308865,2309059..2309121,2309207..2309389) VII 1 NT_166526.1 Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S27 - Homo sapiens; cytoplasm; See PMID 8908372; 40S ribosomal protein eS27 2309389 4985183 An11g09670 Aspergillus niger 40S ribosomal protein eS27 XP_001394925.1 2308863 D 5061 CDS An11g09680 4985184 2310555..2311424 VII 1 NT_166526.1 Catalytic activity: 5,6,7,8-tetrahydrofolate + nadp(+) = 7,8-dihydrofolate + nadph.; Remark: alternate names in Schizosaccharomyces pombe = dfr1 or spcc1223. 08c; Remark: essential step for de novo glycine and purine synthesis.; Remark: the predicted ORF is 214 amino acids shorter at the C-terminus than dfr1 of S. pombe.; Title: similarity to dihydrofolate reductase dfr1p -Schizosaccharomyces pombe; See PMID 8088538; uncharacterized protein 2311424 4985184 An11g09680 Aspergillus niger uncharacterized protein XP_059601678.1 2310555 D 5061 CDS An11g09690 4985185 complement(join(2311540..2312139,2312191..2312679,2312736..2312972,2313028..2313084,2313136..2313219)) VII 1 NT_166526.1 Complex: Rpn5p is a subunit of the 19S proteasome regulatory particle.; Remark: subcellular distribution of proteasomes implicates a major location of protein degradation in the nuclear envelope-ER network in yeast.; Title: strong similarity to proteasome 19S regulatory particle subunit Rpn5 - Saccharomyces cerevisiae; uncharacterized protein 2313219 4985185 An11g09690 Aspergillus niger uncharacterized protein XP_001394927.1 2311540 R 5061 CDS An11g09700 4985186 2314374..2316038 VII 1 NT_166526.1 Catalytic activity: S-adenosyl-L-methionine + uroporphyrin III = S-adenosyl-L-homocysteine + sirohydrochlorin.; Pathway: biosynthesis of sirohemes and cobalamins.; Title: similarity to siroheme synthase cysG -Escherichia coli; See PMID 2407558; uncharacterized protein 2316038 4985186 An11g09700 Aspergillus niger uncharacterized protein XP_001394928.1 2314374 D 5061 CDS An11g09710 4985187 complement(join(2316339..2316687,2316779..2317827,2317891..2318119,2318340..2318365)) VII 1 NT_166526.1 Catalytic activity: ATP + 4-coumarate + CoA = AMP + pyrophosphate + 4-coumaroyl-CoA.; Title: strong similarity to 4-coumarate-CoA ligase -Populus tremuloides; uncharacterized protein 2318365 4985187 An11g09710 Aspergillus niger uncharacterized protein XP_059601679.1 2316339 R 5061 CDS An11g09720 10098102 join(2319526..2325980,2326036..2327017) VII 1 NT_166526.1 Function: polyketide synthase PKS1 is required for T-toxin production in Cochliobolus heterostrophus.; Similarity: blastxPATENT hit (p-val=0. 0) to PATENTPROT:R74171 Aspergillus terreus triol polyketide synthase.; Title: strong similarity to polyketide synthase PKS1 - Cochliobolus heterostrophus; See PMID 8953776; uncharacterized protein 2327017 10098102 An11g09720 Aspergillus niger uncharacterized protein XP_003188852.2 2319526 D 5061 CDS An11g09730 4985189 join(2327359..2327408,2327480..2327561,2327645..2327834,2328028..2328053,2328298..2329116,2329384..2329488,2329561..2329712,2329782..2330889) VII 1 NT_166526.1 Function: deoxyriboaldolase is involved in the salvage pathway for nucleosides in Mycoplasma pirum (strain BER).; Title: similarity to deoxyribose-phosphate aldolase SGC3 - Mycoplasma pirum; See PMID 8349569; uncharacterized protein 2330889 4985189 An11g09730 Aspergillus niger uncharacterized protein XP_001394931.3 2327359 D 5061 CDS An11g09740 4985190 complement(join(<2331434..2332269,2332348..2332695)) VII 1 NT_166526.1 Complex: S. pombe Crb3 bindins to the R3-region of the replication checkpoint control protein Cut5p in two-hybrid and co-immunprecipitation experiments.; Function: S. pombe Crb3p is an essential protein for viability and may be implicated in the G1/S progression.; Remark: ORF 3'truncated due to end of contig.; Similarity: S. pombe Crb3 is a WD repeat containing protein.; Title: similarity to damage and replication checkpoint control protein crb3p - Schizosaccharomyces pombe [truncated ORF]; See PMID 9407031; uncharacterized protein 2332695 4985190 An11g09740 Aspergillus niger uncharacterized protein XP_001394932.3 2331434 R 5061 CDS An11g09750 4985191 join(2333893..2334981,2335032..2335967) VII 1 NT_166526.1 Similarity: similarity is from the predicted A. niger protein to the C-terminal half of L. pealeii NF-220 which is 600 aa longer.; Similarity: the location of introns in L. pealeii NF-220 protein shows that it is more closely related to nuclear lamins and type III intermediate-filament proteins than to vertebrate NF proteins.; Title: weak similarity to neurofilament protein NF-220 - Loligo pealei; See PMID 1379729; uncharacterized protein 2335967 4985191 An11g09750 Aspergillus niger uncharacterized protein XP_001394933.1 2333893 D 5061 CDS An11g09760 4985192 2336601..2337851 VII 1 NT_166526.1 Function: E. coli lipoate synthase is a homodimer required for the C-S bond formation at nonactivated carbon in the biosynthesis of lipoic acid from octanoic acid.; Function: lipoic acid is a detoxifying molecule due to its metal chelating capacity, its ability to scavenge reactive oxygen species (ROS), its ability to regenerate endogenous antioxidants and its ability to repair oxidative damage.; Function: the S. cerevisiae lip5 mutant is not capable of synthesizing lipoic acid but still possesses the activity necessary for attachment of lipoic acid to protein.; Localization: S. cerevisiae Lip5p contains mitochondrial targeting signals and is required for mitochondrial fatty acid metabolism.; Title: strong similarity to lipoic acid synthase Lip5 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8349643; See PMID 9378235; See PMID 11153271; uncharacterized protein 2337851 4985192 An11g09760 Aspergillus niger uncharacterized protein XP_001394934.1 2336601 D 5061 CDS An11g09770 4985193 complement(join(2338724..2339038,2339111..2339368,2339428..2340264)) VII 1 NT_166526.1 Function: S. cerevisiae Ser2p is required for Serine and glycine biosynthesis in yeast using 3-phosphoglycerate.; Title: strong similarity to phosphoserine phosphatase Ser2 - Saccharomyces cerevisiae; See PMID 1326413; uncharacterized protein 2340264 4985193 An11g09770 Aspergillus niger uncharacterized protein XP_001394935.1 2338724 R 5061 CDS An11g09780 4985195 join(2341513..2341693,2341753..2342501) VII 1 NT_166526.1 Catalytic activity: PAPS reductases catalyse 5-phosphoadenosine 3-phosphosulfate + reduced thioredoxin <=> phosphoadenosine phosphate + oxidized thioredoxin + sulfite.; Function: involved in sulfate assimilation pathway for biosynthesis of methionine and cysteine.; Remark: 3'-phosphoadenylyl thiosulfotransferases are also called PAPS reductases etc.; Remark: the predicted ORF together with ORF 350cg are homologues to A. terreus and A. nidulans genes involved in the assimilatory reduction of sulfur for the biosynthesis of cysteine and methionine.; Title: strong similarity to 3-phosphoadenylyl thiosulfotransferase sAT - Aspergillus terreus; See PMID 11057445; uncharacterized protein 2342501 4985195 An11g09780 Aspergillus niger uncharacterized protein XP_001394937.1 2341513 D 5061 CDS An11g09790 4985196 join(2345663..2345831,2345939..2345966,2346101..2346283,2346519..2346664,2346740..2346809,2346882..2348010) VII 1 NT_166526.1 Catalytic activity: catalyzes the reaction of sulfate and ATP to form adenylylsulfate and pyrophosphate.; Function: ATP sulfurylase is involved in the assimilation of sulfur, that leads to the biosynthesis of methionine and cysteine.; Remark: the predicted ORF together with ORF 360cg are homologues to A. terreus and A. nidulans genes involved in the assimilatory reduction of sulfur for the biosynthesis of cysteine and methionine.; Repression: allosterically inhibited by 3'-phosphoadenosine 5'-phosphosulfate (paps) (by similarity).; Title: strong similarity to sulfate adenylyltransferase sC - Aspergillus nidulans; See PMID 7770049; See PMID 9343344; See PMID 2162344; uncharacterized protein 2348010 4985196 An11g09790 Aspergillus niger uncharacterized protein XP_001394938.1 2345663 D 5061 CDS An11g09800 4985197 2348386..2350128 VII 1 NT_166526.1 hypothetical protein 2350128 4985197 An11g09800 Aspergillus niger hypothetical protein XP_001394939.3 2348386 D 5061 CDS An11g09820 4985199 complement(join(2351179..2352365,2352426..2353824)) VII 1 NT_166526.1 Remark: Similarity is based on repetitive sequence.; Title: weak similarity to filamentous hemagglutinin fhaB - Bortedella pertussis; uncharacterized protein 2353824 4985199 An11g09820 Aspergillus niger uncharacterized protein XP_001394940.1 2351179 R 5061 CDS An11g09830 4985200 complement(join(2356509..2357001,2357065..2357162,2357227..2357418)) VII 1 NT_166526.1 Title: weak similarity to hypothetical protein B0280.2 - Caenorhabditis elegans; uncharacterized protein 2357418 4985200 An11g09830 Aspergillus niger uncharacterized protein XP_001394941.1 2356509 R 5061 CDS An11g09840 4985201 join(2358099..2358149,2358245..2358409,2358534..2358596,2358652..2358701,2358757..2358766) VII 1 NT_166526.1 Title: similarity to polypeptide SEQ ID NO:6214 from patent WO200153312-A1 - Homo sapiens; uncharacterized protein 2358766 4985201 An11g09840 Aspergillus niger uncharacterized protein XP_001394942.3 2358099 D 5061 CDS An11g09850 4985202 join(2359290..2359301,2359423..2362428) VII 1 NT_166526.1 Remark: Similarity is based on repetitive sequence.; Title: weak similarity to OlpB from patent FR2748479-A1 - Clostridium thermocellum; uncharacterized protein 2362428 4985202 An11g09850 Aspergillus niger uncharacterized protein XP_001394943.1 2359290 D 5061 CDS An11g09860 4985203 complement(join(2362619..2362678,2362768..2362864,2362962..2362981,2363127..2363181,2363247..2363264,2363933..2363951,2364300..2365021,2365082..2365254,2365338..2365711,2365765..2366884)) VII 1 NT_166526.1 Function: The determined state of Drosophila imaginal discs depends on stable patterns of homeotic gene expression. The stability of these patterns requires the function of the ash1 gene.; Remark: The ASH1 protein contains a SET domain and a PHD finger. The ASH1 protein is localized on polytene chromosomes of larval salivary glands at > 100 sites.; Similarity: a member of the trithorax group; Title: similarity to protein ash1 - Drosophila melanogaster; See PMID 8725238; See PMID 9663389; uncharacterized protein 2366884 4985203 An11g09860 Aspergillus niger uncharacterized protein XP_059606391.1 2362619 R 5061 CDS An11g09870 4985204 complement(join(2368283..2369195,2369250..2369857)) VII 1 NT_166526.1 Title: similarity to hypothetical protein SPBC3H7.09 - Schizosaccharomyces pombe; uncharacterized protein 2369857 4985204 An11g09870 Aspergillus niger uncharacterized protein XP_059606392.1 2368283 R 5061 CDS An11g09880 4985205 join(2370885..2371232,2371306..2371349,2371510..2371711,2371807..2371920) VII 1 NT_166526.1 Title: similarity to hypothetical protein CAE76201.1 - Neurospora crassa; uncharacterized protein 2371920 4985205 An11g09880 Aspergillus niger uncharacterized protein XP_059606393.1 2370885 D 5061 CDS An11g09890 4985206 complement(join(2372291..2372824,2372883..2374343,2374407..2374690,2374744..2375033,2375104..2375369)) VII 1 NT_166526.1 Catalytic activity: Dolichyl phosphate D-mannose + Protein = Dolichyl phosphate + O-D-Mannosylprotein; Function: Protein mannosylation by Pmt proteins initiates O-glycosylation in fungi; Remark: Mutants defective in PMT1 alleles lacked Pmt in vitro enzymatic activity, showed reduced growth rates,and tended to form cellular aggregates; Title: strong similarity to mannosyltransferase 1 PMT1 - Candida albicans; See PMID 9694829; uncharacterized protein 2375369 4985206 An11g09890 Aspergillus niger uncharacterized protein XP_001394947.1 2372291 R 5061 CDS An11g09900 4985207 join(2376291..2376381,2376438..2376491,2376556..2378024) VII 1 NT_166526.1 Complex: mammalian splicing factor SF3a binds to transcription factor Sp1.; Function: mammalian splicing factor SF3a consists of three subunits of 60, 66, and 120 kDa and functions early during pre-mRNA splicing by converting the U2 snRNP into its active form.; Title: similarity to splicing factor SF3a 120K chain - Homo sapiens; nucleus; See PMID 7489498; See PMID 10976766; uncharacterized protein 2378024 4985207 An11g09900 Aspergillus niger uncharacterized protein XP_001394948.1 2376291 D 5061 CDS An11g09910 4985208 complement(join(2379082..2380515,2380577..2381219,2381288..2381295)) VII 1 NT_166526.1 Function: SEC2 function is required at the post-Golgi apparatus stage of the yeast secretory pathway for the polarized transport of secretory vesicles in S. cerevisiae; Title: strong similarity to protein Sec2 -Saccharomyces cerevisiae; See PMID 10747090; See PMID 1693620; uncharacterized protein 2381295 4985208 An11g09910 Aspergillus niger uncharacterized protein XP_001394949.1 2379082 R 5061 CDS An11g09920 4985209 join(2383264..2383287,2383413..2383501,2383571..2383581,2383684..2383964) VII 1 NT_166526.1 Function: TFAR19 may play a general role in the apoptotic process.; Remark: TFAR19 exhibits a ubiquitous expression pattern and its expression is upregulated in the tumor cells undergoing apoptosis. Overexpression of TFAR19 in tumor cells enhances apoptosis triggered by growth factor or serum deprivation.; Similarity: The human TFAR19 encodes a protein which shares significant homology to the corresponding proteins of species ranging from yeast to mice.; Title: similarity to protein TFAR19 - Homo sapiens; See PMID 9920759; uncharacterized protein 2383964 4985209 An11g09920 Aspergillus niger uncharacterized protein XP_001394950.1 2383264 D 5061 CDS An11g09930 4985210 complement(join(2384229..2384878,2384940..2385162)) VII 1 NT_166526.1 Remark: Mutant strains harboring mutations in the coq3, coq4, coq5, coq6, coq7, or coq8 genes are unable to produce Ubiquinone.; Title: strong similarity to ubiquinone biosynthesis protein Coq4 - Saccharomyces cerevisiae; See PMID 9266513; uncharacterized protein 2385162 4985210 An11g09930 Aspergillus niger uncharacterized protein XP_001394951.1 2384229 R 5061 CDS An11g09940 4985211 join(2385570..2385710,2385786..2386346,2386416..2386470,2386542..2386604,2386668..2387179) VII 1 NT_166526.1 Catalytic activity: S-Adenosyl-L-methionine + Histone-L-lysine = S-Adenosyl-L-homocysteine + Histone N6-methyl-L-lysine.; Title: similarity to histone-lysine N-methyltransferase LSMT - Pisum sativum; See PMID 7888616; See PMID 10593982; uncharacterized protein 2387179 4985211 An11g09940 Aspergillus niger uncharacterized protein XP_059606394.1 2385570 D 5061 CDS An11g09950 4985212 complement(join(2387294..2387345,2387392..2388524)) VII 1 NT_166526.1 Catalytic activity: (r)-pantoate + nadp(+) = 2-dehydropantoate + nadph.; Function: catalyzes the nadph-dependent reduction of ketopantoate into pantoic acid.; Localization: cytoplasmic (potential).; Pathway: alternative pyrimidine biosynthetic (apb) pathway.; Similarity: to ketopantoate reductases from bacteria.; Title: similarity to ketopantoate reductase apbA -Salmonella typhimurium; See PMID 9721324; uncharacterized protein 2388524 4985212 An11g09950 Aspergillus niger uncharacterized protein XP_059606395.1 2387294 R 5061 CDS An11g09960 4985213 join(2388939..2389119,2389169..2389335,2389388..2389714) VII 1 NT_166526.1 Remark: C1D encodes a DNA-binding and DNA-PK-activating protein.; Title: weak similarity to DNA-binding protein C1D -Homo sapiens; See PMID 9852280; See PMID 10362552; uncharacterized protein 2389714 4985213 An11g09960 Aspergillus niger uncharacterized protein XP_001394954.3 2388939 D 5061 CDS An11g09970 4985214 join(2390526..2390773,2390842..2391106,2391207..2391239) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein YMR002w - Saccharomyces cerevisiae; uncharacterized protein 2391239 4985214 An11g09970 Aspergillus niger uncharacterized protein XP_001394955.1 2390526 D 5061 CDS An11g09980 4985215 complement(join(2391512..2391538,2391568..2391615,2391747..2392408,2392478..2392827,2392874..2393099,2393179..2393257)) VII 1 NT_166526.1 Function: PspA is a virulence factor of the bacteria that has been shown to protect mice against pneumococcal infection. The amino-terminal part of PspA has been found to be a functional module which is essential for full pneumococcal infectivity.; Remark: Pneumococcal surface protein A (PspA) is one of the major antigens of Streptococcus pneumonia.; Remark: Similarity is based on repetitive sequence.; Title: similarity to pneumococcal surface protein A pspA - Streptococcus pneumoniae; See PMID 10992499; See PMID 11087677; uncharacterized protein 2393257 4985215 An11g09980 Aspergillus niger uncharacterized protein XP_059606396.1 2391512 R 5061 CDS An11g09985 4985216 join(2394026..2394350,2394446..2394551,2394635..2394734) VII 1 NT_166526.1 Title: similarity to protein SURF1 - Mus musculus; See PMID 3025660; uncharacterized protein 2394734 4985216 An11g09985 Aspergillus niger uncharacterized protein XP_001394957.3 2394026 D 5061 CDS An11g09990 4985217 complement(join(2394947..2395505,2395555..2396216,2396264..>2396356)) VII 1 NT_166526.1 Title: weak similarity to hypothetical protein encoded by SPBC800.13 - Schizosaccharomyces pombe; uncharacterized protein 2396356 4985217 An11g09990 Aspergillus niger uncharacterized protein XP_001394958.3 2394947 R 5061 CDS An11g10000 4985218 join(2396716..2397103,2397153..2397333,2397390..2397488,2397535..2397587,2397623..2397819) VII 1 NT_166526.1 Title: similarity to hypothetical protein SPBC23G7.07c - Schizosaccharomyces pombe; uncharacterized protein 2397819 4985218 An11g10000 Aspergillus niger uncharacterized protein XP_059606397.1 2396716 D 5061 CDS An11g10010 84592408 complement(2399094..2400263) VII 1 NT_166526.1 Title: similarity to hypothetical protein encoded by An16g04370 - Aspergillus niger; uncharacterized protein 2400263 84592408 An11g10010 Aspergillus niger uncharacterized protein XP_059606398.1 2399094 R 5061 CDS An11g10020 4985220 join(2403647..2404169,2404237..2404465,2404524..2404713) VII 1 NT_166526.1 Similarity: Similarity is based on repetitive sequences.; Title: similarity to wound-responsive protein KED -Nicotiana tabacum; See PMID 10945337; uncharacterized protein 2404713 4985220 An11g10020 Aspergillus niger uncharacterized protein XP_001394961.1 2403647 D 5061 CDS An11g10030 4985221 complement(join(2405266..2405326,2405382..2405614,2405674..2405833,2405926..2405984,2406095..2406127,2406193..2406225)) VII 1 NT_166526.1 Title: strong similarity to hypothetical rac GTPase AAD50299.1 - Xenopus laevis; uncharacterized protein 2406225 4985221 An11g10030 Aspergillus niger uncharacterized protein XP_059606399.1 2405266 R 5061 CDS An11g10050 4985222 complement(join(2408172..2408330,2408378..2408547,2408726..2408769,2409012..2409219,2409270..2409779,2409834..2410099,2410145..2410582,2410634..2410926)) VII 1 NT_166526.1 Function: The Leu3 protein of yeast is a dual-function regulator, stimulating transcription when the inducer alpha-isopropylmalate (alpha-IPM) is present and suppressing transcription when the inducer is absent.; Remark: Yeast zinc cluster proteins form a major class of yeast transcriptional regulators. They usually bind as homodimers to target DNA sequences, with each monomer recognizing a CGG triplet. Orientation and spacing between the CGG triplet specifies the recognition sequence for a given zinc cluster protein . Leu3p, also recognize CGG triplets but when oriented in opposite directions, an everted repeat.; Similarity: Leu3p, belongs to the family of Zn(II)2Cys6 proteins.; Title: similarity to leucine-specific regulatory protein Leu3 - Saccharomyces cerevisiae; nucleus; See PMID 8428928; See PMID 8706857; See PMID 9660826; See PMID 10383402; uncharacterized protein 2410926 4985222 An11g10050 Aspergillus niger uncharacterized protein XP_001394963.3 2408172 R 5061 CDS An11g10060 4985223 join(2411584..2411824,2412055..2412076,2412370..2412562,2412635..2412688,2412772..2413378,2413432..2413640,2413696..2414260,2414321..2414464,2414518..2414612,2414671..2414741,2414795..2414906) VII 1 NT_166526.1 Title: strong similarity to hypothetical GTPase activating protein GAP1 - Cochliobolus heterostrophus; uncharacterized protein 2414906 4985223 An11g10060 Aspergillus niger uncharacterized protein XP_001394964.3 2411584 D 5061 CDS An11g10070 4985224 complement(join(2415723..2416218,2416291..2416398,2416468..2416835)) VII 1 NT_166526.1 Title: weak similarity to hypothetical protein SPAC13G7.11 - Schizosaccharomyces pombe; uncharacterized protein 2416835 4985224 An11g10070 Aspergillus niger uncharacterized protein XP_001394965.1 2415723 R 5061 CDS An11g10080 4985225 join(2417905..2417910,2417980..2418035,2418088..2418235,2418353..2418570,2418741..2418780) VII 1 NT_166526.1 Title: weak similarity to hypothetical protein CAE76369.1 - Neurospora crassa; uncharacterized protein 2418780 4985225 An11g10080 Aspergillus niger uncharacterized protein XP_059606400.1 2417905 D 5061 CDS An11g10090 4985226 complement(join(2419381..2419529,2419586..2419678,2419789..2419863,2420108..2420135)) VII 1 NT_166526.1 Function: additional factor that functions in concert with eif-2 and the initiator trna in directing the ribosome to the proper start site of translation.; Remark: evidence for direct interaction between rent2 and human eIF4AI and Sui1, both are components of the translation initiation complex.; Similarity: belongs to the sui1 family.; Title: strong similarity to translation factor sui1p - Schizosaccharomyces pombe; See PMID 11073994; uncharacterized protein 2420135 4985226 An11g10090 Aspergillus niger uncharacterized protein XP_001394967.1 2419381 R 5061 CDS An11g10100 4985227 complement(join(2421035..2421115,2421174..2421190,2421256..2421353,2421408..2421419,2421486..2421502,2421573..2421604,2421679..2421729,2421812..2421848)) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein EAA60784.1 - Aspergillus nidulans; uncharacterized protein 2421848 4985227 An11g10100 Aspergillus niger uncharacterized protein XP_001394968.1 2421035 R 5061 CDS An11g10110 4985228 join(2425098..2425701,2425765..2426362,2426412..2426616,2426667..2427305,2427359..2427657,2427708..2428587,2428687..2428981,2429032..2429258,2429314..2430321) VII 1 NT_166526.1 Function: Srb/mediator proteins that are associated with RNA polymerase II holoenzyme have been implicated in transcriptional repression in S. cerevisiae; Remark: The products of all nine SRB genes identified are components of the RNA polymerase II holoenzyme.; Title: similarity to protein Srb8 - Saccharomyces cerevisiae; nucleus; See PMID 7774808; See PMID 9755175; uncharacterized protein 2430321 4985228 An11g10110 Aspergillus niger uncharacterized protein XP_059606401.1 2425098 D 5061 CDS An11g10120 84592409 join(2433104..2433257,2433352..2433479) VII 1 NT_166526.1 Induction: Expression of the qid3 gene is derepressed in the absence of glucose.; Localization: QID3 is encoding a putative cell wall protein.; Remark: When introduced in yeast, qid3 expression causes cell division arrest into cytokinesis and cell separation, probably due to its cell wall localization.; Similarity: belongs to hydrophobin HFBI superfamily.; Title: weak similarity to QID3 - Trichoderma harzianum; See PMID 8121402; uncharacterized protein 2433479 84592409 An11g10120 Aspergillus niger uncharacterized protein XP_059606402.1 2433104 D 5061 CDS An11g10130 84592410 complement(join(2433899..2434629,2434770..2434834,2434896..2435053)) VII 1 NT_166526.1 Title: similarity to hypothetical protein T29A15.10 - Arabidopsis thaliana; uncharacterized protein 2435053 84592410 An11g10130 Aspergillus niger uncharacterized protein XP_059606403.1 2433899 R 5061 CDS An11g10140 4985231 join(2436378..2436465,2436535..2436768,2436842..2437009,2437184..2437563) VII 1 NT_166526.1 Function: CIA30 is a novel chaperone specific for complex I membrane arm assembly.; Title: strong similarity to NADH:ubiquinone reductase intermediate-associated protein CIA30 -Neurospora crassa; See PMID 9769214; uncharacterized protein 2437563 4985231 An11g10140 Aspergillus niger uncharacterized protein XP_059606404.1 2436378 D 5061 CDS An11g10150 4985232 complement(join(2437714..2438090,2438155..2438530,2438606..2438755)) VII 1 NT_166526.1 Catalytic activity: ATP + 1-(5'-Phosphoribosyl)-5-amino-4-carboxyimidazole + L-Aspartate = ADP + Orthophosphate + 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imi dazole; Function: involved in purine biosynthesis.; Induction: The promoter of the ADE1 gene contains a copy of the 5'-TGACTC hexanucleotide, a feature characteristic of promoters under general aa control.; Pathway:The ade4, ade5, ade8, ade6, and ade7 mutations were found to suppress the phenotypic manifestation of the ade2 mutations via inactivation of enzymes catalyzing the first, second, third, fourth and fifth stages of purine biosynthesis, while the ade1 mutation, which inactivates enzyme of the seventh stage,lacks suppressive activity.; Remark: Strains with single adenine mutations, ade4,ade5, ade8, ade6, ade7, or ade1 grow on glycerol- and hypoxanthine-containing media.; Title: strong similarity to phosphoribosylaminoimidazolesuccinocarboxamide synthase Ade1 - Saccharomyces cerevisiae; See PMID 1756975; uncharacterized protein 2438755 4985232 An11g10150 Aspergillus niger uncharacterized protein XP_001394973.1 2437714 R 5061 CDS An11g10160 4985233 complement(2439081..2440130) VII 1 NT_166526.1 Function: oxetanocin A selective inhibits the replication of several viral particles,like the human cytomegalovirus.; Remark: Bacillus megaterium strain NK84-0218 produces a potent antiviral nuclesosid, oxetanocin A, which has an oxetanosyl-N-glycoside linkage to an adenine moiety.; Title: strong similarity to hypothetical oxetanocin A resistance protein oxrB - Bacillus megaterium; See PMID 10227144; uncharacterized protein 2440130 4985233 An11g10160 Aspergillus niger uncharacterized protein XP_001394974.1 2439081 R 5061 CDS An11g10170 84592411 join(2441450..2441644,2441762..2441911,2442063..2442185) VII 1 NT_166526.1 hypothetical protein 2442185 84592411 An11g10170 Aspergillus niger hypothetical protein XP_059606405.1 2441450 D 5061 CDS An11g10180 4985235 complement(join(2442939..2443756,2443808..2444042)) VII 1 NT_166526.1 Remark: the G. zeae mating-type protein MAT 1-1 is a member of the proteins controling the reproductive mode of G. zeae, G. fujikuroi and the asexual F. oxysporum.; Title: similarity to mating type protein MAT1-1-1 -Gibberella zeae; See PMID 11118131; uncharacterized protein 2444042 4985235 An11g10180 Aspergillus niger uncharacterized protein XP_001394976.3 2442939 R 5061 CDS An11g10190 4985236 complement(join(2446155..2446312,2446435..2446821,2447047..2447323,2447377..2448086,2448138..2448270,2448320..2448365,2448481..2448488)) VII 1 NT_166526.1 Function: APN2 of S. cerevisiae contains both 3'-phosphodiesterase activity and 3'->5' exonuclease activity and has a role in the repair of H(2)O(2)-induced DNA damage.; Remark: APN2 of S. cerevisiae is also known as ETH1 and YBL019W.; Similarity: APN2 of S. cerevisiae is a member of the class II AP endonucleases.; Title: similarity to apurinic/apyrimidinic (AP) endonuclease Apn2 - Saccharomyces cerevisiae; See PMID 9765213; See PMID 10806210; See PMID 11238902; uncharacterized protein 2448488 4985236 An11g10190 Aspergillus niger uncharacterized protein XP_059606406.1 2446155 R 5061 CDS An11g10200 4985237 join(2449044..2449230,2449310..2449334,2449395..2449554,2449624..2449631,2449714..2449759) VII 1 NT_166526.1 Function: subunit of the cytochrome c oxidase, the final component of the respiratory chain, that catalyzes the electron transfer from cytochrome c to oxygen.; Title: strong similarity to subunit VIa of cytochrome c oxidase Cox13 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8395517; uncharacterized protein 2449759 4985237 An11g10200 Aspergillus niger uncharacterized protein XP_001394978.1 2449044 D 5061 CDS An11g10210 4985238 complement(join(2450133..2450862,2450911..2451047,2451096..2451202,2451303..2451380,2451442..2451848,2451900..2451993,2452047..2452764)) VII 1 NT_166526.1 Complex: the human anaphase-promoting complex is composed of eight protein subunits (BimE/APC1, CDC27/APC3,CDC16/APC6, CDC23/APC8, APC2, APC4, APC5, and APC7).; Function: human anaphase-promoting complex has E3-ubiquitin ligase activity and controls all postmetaphase events.; Title: similarity to anaphase-promoting complex subunit APC5 - Homo sapiens; See PMID 9469815; See PMID 10872461; uncharacterized protein 2452764 4985238 An11g10210 Aspergillus niger uncharacterized protein XP_059606407.1 2450133 R 5061 CDS An11g10230 84592412 complement(join(2453232..2453282,2453332..2453373)) VII 1 NT_166526.1 hypothetical protein 2453373 84592412 An11g10230 Aspergillus niger hypothetical protein XP_059606408.1 2453232 R 5061 CDS An11g10240 4985241 join(2454044..2454715,2454770..2454788,2454844..2455883) VII 1 NT_166526.1 hypothetical protein 2455883 4985241 An11g10240 Aspergillus niger hypothetical protein XP_001394981.3 2454044 D 5061 CDS An11g10250 84592413 join(2456088..2456218,2456273..2456441,2456479..2457087) VII 1 NT_166526.1 Remark: the human GS1 protein is encoded by a gene that is of interest because it is one of the few X-linked genes that escapes X-inactivation.; Title: strong similarity to cDNA GS1 - Homo sapiens; See PMID 1284467; uncharacterized protein 2457087 84592413 An11g10250 Aspergillus niger uncharacterized protein XP_059606409.1 2456088 D 5061 CDS An11g10260 4985243 complement(join(2457764..2457805,2457863..2458003,2458067..2458432,2458482..2458576,2458626..2459019)) VII 1 NT_166526.1 Golgi; Remark: K. lactis alphaN-acetylglucosamine transferase is predicted to be a Golgi membrane transporter, who tranfers UDP-GlcNAc into the lumen, where it is a substrate in the biosynthesis of mannoproteins.; Title: strong similarity to alphaN-acetylglucosamine transferase - Kluyveromyces lactis; See PMID 8650202; uncharacterized protein 2459019 4985243 An11g10260 Aspergillus niger uncharacterized protein XP_001394983.1 2457764 R 5061 CDS An11g10270 84592414 join(2460580..2460907,2460941..2461962) VII 1 NT_166526.1 Title: strong similarity to aspartic protease polypeptide #4 from patent WO200268623-A2. - Aspergillus niger; uncharacterized protein 2461962 84592414 An11g10270 Aspergillus niger uncharacterized protein XP_059606410.1 2460580 D 5061 CDS An11g10280 84592415 join(2463007..2463325,2463356..2464398) VII 1 NT_166526.1 Remark: the P. anserina het-e-1 gene of the fungus Podospora anserina is responsible for vegetative incompatibility through specific interactions with different alleles of the unlinked gene, het-c.; Title: weak similarity to beta-transducin like protein het-e1 - Podospora anserina; See PMID 7557402; See PMID 9435787; uncharacterized protein 2464398 84592415 An11g10280 Aspergillus niger uncharacterized protein XP_059606411.1 2463007 D 5061 CDS An11g10290 4985246 complement(2464695..2466194) VII 1 NT_166526.1 Catalytic activity: E. coli betaine-aldehyde dehydrogenase converts betaine aldehyde and NAD(+)and H(2)O to betaine and NADH.; Complex: betB of E. coli exists as a homotetramer.; Pathway: E. coli betaine-aldehyde dehydrogenase is part of the glycine, serine and threonine metabolism.; Remark: E. coli betaine-aldehyde dehydrogenase belongs to the superfamiliy of oxidureductases.; Title: strong similarity to betaine-aldehyde dehydrogenase betB - Escherichia coli; See PMID 2194570; See PMID 1956285; uncharacterized protein 2466194 4985246 An11g10290 Aspergillus niger uncharacterized protein XP_001394986.1 2464695 R 5061 CDS An11g10300 4985247 2466771..2468222 VII 1 NT_166526.1 Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to hypothetical protein CAD16864.1 - Ralstonia solanacearum; uncharacterized protein 2468222 4985247 An11g10300 Aspergillus niger uncharacterized protein XP_001394987.1 2466771 D 5061 CDS An11g10310 4985248 join(2468675..2468782,2468866..2469053,2469112..2469275,2469329..2469632,2469691..2470269,2470363..2470381) VII 1 NT_166526.1 Complex: the P. acaligenes GDO structure is deduced to be a tetramer.; Induction: the P. alcaligenes GDO can be induced through 3-hydroxybenzoate.; Similarity: hte P. alcaligenes belongs to the cupin superfamily, which are functionally diverse proteins that share a highly conserved pattern of two histidine-containing motifs with a varied intermotif spacing.; Title: similarity to gentisate 1,2-dioxygenases GDO - Pseudomonas alcaligenes; See PMID 10049846; uncharacterized protein 2470381 4985248 An11g10310 Aspergillus niger uncharacterized protein XP_001394988.3 2468675 D 5061 CDS An11g10320 4985249 complement(join(2470691..2470777,2470834..2471201,2471234..2472063,2472155..2472233,2472308..2473360,2473416..2473600,2473652..2473709,2473760..2473840,2473904..2474061,2474132..2474207,2474303..2474320,2474384..2474430,2474511..2474518)) VII 1 NT_166526.1 Function: the S. cerevisiae SLA2 protein is required for cellular morphogenesis and polarization of cortical cytoskeleton.; Remark: SLA2 of S. cerevisiae is also known as END4,MOP2 and YNL243W.; Similarity: the C-terminal part of the predicted A. niger protein shows strong similarity to the C-terminal part of the human Talin TLN protein, which is a cytoskeletal focal adhesion protein.; Title: strong similarity to cytoskeleton assembly control protein homolog Sla2 - Saccharomyces cerevisiae; cytoskeleton; See PMID 8335689; uncharacterized protein 2474518 4985249 An11g10320 Aspergillus niger uncharacterized protein XP_059606412.1 2470691 R 5061 CDS An11g10330 4985250 complement(join(2475537..2477847,2477941..2478550,2478912..2478924)) VII 1 NT_166526.1 Remark: an alternative name for the predicted S. cerevisiae protein is P9513. 15.; Title: strong similarity to hypothetical membrane protein YPR091c - Saccharomyces cerevisiae; uncharacterized protein 2478924 4985250 An11g10330 Aspergillus niger uncharacterized protein XP_001394990.3 2475537 R 5061 CDS An11g10340 4985251 2479947..2480930 VII 1 NT_166526.1 Similarity: the ORF encoded protein shows also weak similartity to hypothetical protein VC1974 from Vibrio cholerae (strain N16961).; Title: strong similarity to hypothetical protein encoded by An02g00110 - Aspergillus niger; uncharacterized protein 2480930 4985251 An11g10340 Aspergillus niger uncharacterized protein XP_001394991.1 2479947 D 5061 CDS An11g10350 4985252 complement(join(2481313..2481481,2481536..2482230,2482298..2482687,2482737..2482850)) VII 1 NT_166526.1 Remark: the C. albicans gene was isolated through complementation of the complementation of fluconazole hypersusceptibility in S. cerevisiae YKKB-13 lacking the ABC (ATP-binding cassette) transporter gene PDR5.; Similarity: the deduced amino acid sequence of FLU1 showed similarity to CaMDR1 (formerly BEN(r)), a member of the major facilitator superfamily of multidrug efflux transporters.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353; uncharacterized protein 2482850 4985252 An11g10350 Aspergillus niger uncharacterized protein XP_001394992.3 2481313 R 5061 CDS An11g10360 84592416 join(2483794..2483799,2483922..2483966,2484065..2484314,2484356..2484366) VII 1 NT_166526.1 hypothetical protein 2484366 84592416 An11g10360 Aspergillus niger hypothetical protein XP_059606413.1 2483794 D 5061 CDS An11g10370 4985254 complement(join(2484615..2484776,2484835..2486025)) VII 1 NT_166526.1 Catalytic activity: S. cerevisiae trans-pentaprenyltranstransferase converts All-trans-pentaprenyl diphosphate and isopentenyl diphosphate to diphosphate and all-trans-hexaprenyl diphosphate.; Function: S. cerevisiae trans-pentaprenyltranstransferase is involved in the CoenzymeQ biosythesis. Coenzyme Q (Ubichinone) is involved in the synthesis of ATP and is an antioxydant.; Remark: the systematical name for the S. cerevisiae COQ1 protein is YBR003W.; Title: strong similarity to trans-pentaprenyltranstransferase Coq1 - Saccharomyces cerevisiae; See PMID 2198286; uncharacterized protein 2486025 4985254 An11g10370 Aspergillus niger uncharacterized protein XP_001394994.1 2484615 R 5061 CDS An11g10380 4985255 complement(join(2486706..2486849,2486917..2488214,2488286..2488781)) VII 1 NT_166526.1 Function: The 26S proteasome is the multiprotein complex that degrades proteins that have been marked for destruction by the ubiquitin pathway.; Title: strong similarity to 26S proteasome regulatory subunit rpn3p - Schizosaccharomyces pombe; See PMID 10582238; uncharacterized protein 2488781 4985255 An11g10380 Aspergillus niger uncharacterized protein XP_059606414.1 2486706 R 5061 CDS An11g10390 4985256 join(2489534..2489598,2489655..2490017,2490080..2490372,2490569..2490738,2490782..2490848,2491004..2491020) VII 1 NT_166526.1 hypothetical protein 2491020 4985256 An11g10390 Aspergillus niger hypothetical protein XP_001394996.3 2489534 D 5061 CDS An11g10400 4985257 join(2491732..2493306,2493372..2493626) VII 1 NT_166526.1 Function: TAF61 of S. cerevisiae has a role in RNA polymerase II transcription where it is required by Gcn4 to recruit the SAGA coactivator complex.; Remark: TAF61 of S. cerevisiae is also known as TAFII61 and YDR145W.; Similarity: the similarity of the ORF to the S. cerevisiae TAF61 is restricted to the C-terminal region, as the ORF is 443 aa longer at the N-terminus.; Title: similarity to subunit of transcription initation factor TFIID Taf61 - Saccharomyces cerevisiae; See PMID 8962109; See PMID 9844640; uncharacterized protein 2493626 4985257 An11g10400 Aspergillus niger uncharacterized protein XP_001394997.1 2491732 D 5061 CDS An11g10410 4985258 complement(join(2495497..2496015,2496068..2496213,2496340..2497028,2497093..2498231)) VII 1 NT_166526.1 Function: phosphatidylinositol-5-kinase catalyzes the last step in the synthesis of phosphatidylinositol 4,5-bisphosphate. phosphatidylinositol 4, 5-bisphosphate is a precursor of diacylglycerol and inositol 1,4,5-trisphosphate, which are important second messengers.; Pathway: S. pombe phosphatidylinositol-5-kinase is thought to be regulated by phosphorylation via casein kinase 1 Cki1.; Title: strong similarity to phosphatidylinositol-4-phosphate 5-kinase -Schizosaccharomyces pombe; plasma membrane; See PMID 9873063; uncharacterized protein 2498231 4985258 An11g10410 Aspergillus niger uncharacterized protein XP_059606415.1 2495497 R 5061 CDS An11g10420 84592417 complement(join(2499423..2499569,2499772..2499842,2500062..2500187,2500360..2500393,2500465..2500531,2500569..2500681,2501212..2501277)) VII 1 NT_166526.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 2501277 84592417 An11g10420 Aspergillus niger uncharacterized protein XP_059606416.1 2499423 R 5061 CDS An11g10430 4985260 complement(join(2502296..2502346,2502495..2502671,2502732..2502790,2502953..2503083,2503209..2503231,2503392..2503417,2503513..2503582)) VII 1 NT_166526.1 Function: histone H1, similar to H5, normally acts as linker histone connecting nucleosomes to form the 30-nm chromatin fiber.; Localization: an H1-GFP fusion shows exclusive nuclear localization, whereas chromosomal localization can be observed during condensation at mitosis.; Phenotype: deletion of the hhoa gene of A. nidulans results in no obvious phenotype: nucleosomal repeat length and susceptibility to micrococcal nuclease digestion remained unaffected as well as the nucleosomal organization of a number of promoters.; Similarity: hhoa of A. nidulans belongs to the histone H1/H5 family.; Similarity: the A. niger EST an_2114 in EMBLEST:BE759338 overlaps with the ORF.; Similarity: the A. niger Nig013 in EMBLEST:AN732 overlaps with the ORF.; Title: strong similarity to histone H1 hhoA -Aspergillus nidulans; nucleus; See PMID 10984712; See PMID 11149891; uncharacterized protein 2503582 4985260 An11g10430 Aspergillus niger uncharacterized protein XP_001395000.1 2502296 R 5061 CDS An11g10440 84592418 join(2504603..2504681,2504778..2504878,2505192..2505320) VII 1 NT_166526.1 Remark: unusual intron/exon structure for A. niger and short length (102 amino acids).; Title: questionable ORF; uncharacterized protein 2505320 84592418 An11g10440 Aspergillus niger uncharacterized protein XP_059606417.1 2504603 D 5061 CDS An11g10450 4985262 complement(join(2506409..2506930,2506992..2507553,2507607..2507611,2507704..2507789,2507886..2507898)) VII 1 NT_166526.1 Catalytic activity: Rad2p possesses a 5'-->3' single-stranded exonuclease activity.; Function: the rad2 protein of S. pombe is essential for repair of DNA damage after UV-irradiation.; Function: the rad2 protein of S. pombe is involved in Okazaki fragment processing (DNA replication).; Function: the rad2 protein of S. pombe is involved in the fidelity of chromosome segregation.; Phenotype: the rad2 mutant of S. pombe has additionally a very high degree of chromosome loss and/or nondisjunction.; Phenotype: the rad2 mutant of S. pombe is deficient in the repair of UV damage.; Remark: the rad2 protein of S. pombe is also called SPAC3G6. 06C and FEN1 (flap endonuclease 1).; Similarity: rad2 of S. pombe belongs to the rad2(pombe)/FEN1 subfamily.; Title: strong similarity to DNA repair protein rad2p - Schizosaccharomyces pombe; nucleus; See PMID 8007985; See PMID 10908351; uncharacterized protein 2507898 4985262 An11g10450 Aspergillus niger uncharacterized protein XP_001395002.1 2506409 R 5061 CDS An11g10460 4985263 join(2508452..2508732,2508813..2509656,2509721..2510887) VII 1 NT_166526.1 Function: prnA of A. nidulans controls the expression of the prn gene cluster, which is necessary for proline utilization as a nitrogen and/or carbon source.; Similarity: the A. niger EST clone 0700 in EMBLEST:BE760806 overlaps with the ORF at the ORF's C-terminus.; Similarity: the ORF shows only local (N-terminal,until amino acid 388) homology to the prnA protein of A. nidulans.; Similarity: the ORF shows similarity to other transcription factors/transcriptional regulators too.; Similarity: the ORF shows weak similarity to A. niger mutant prtT allele polypeptide prt13 from patent WO200020596-A1.; Title: similarity to transcription activator prnA -Aspergillus nidulans; See PMID 9622360; uncharacterized protein 2510887 4985263 An11g10460 Aspergillus niger uncharacterized protein XP_059606418.1 2508452 D 5061 CDS An11g10470 4985264 join(2511794..2512007,2512095..2513010,2513100..2513209,2513280..2513326) VII 1 NT_166526.1 Catalytic activity: GCHD of H. sapiens catalyzes the oxidative carboxylation of glutaryl-CoA to crotonyl-CoA.; Complex: GCDH of H. sapiens is a subunit of a homotetramer.; Function: GCHD of H. sapiens functions in the degradation of lysine, hydroxylysine, and tryptophan (EC: 1. 3. 99. 7).; Localization: GCHD of H. sapiens is localized to the mitochondrial matrix.; Phenotype: deficiency of GCDH in H. sapiens leads to glutaric acidemia type I, an inherited disorder of amino acid metabolism characterized by a progressive neurodegenerative disease.; Remark: GCHD of H. sapiens belongs to the acyl-CoA dehydrogenase family.; Remark: a splice site was detected upstream of the START codon.; Similarity: the ORF shows also strong similarity to acyl-CoA dehydrogenases of several species (EC: 1. 3. 99. 3).; Title: strong similarity to glutaryl-CoA dehydrogenase GCHD - Homo sapiens; See PMID 8541831; See PMID 9600243; uncharacterized protein 2513326 4985264 An11g10470 Aspergillus niger uncharacterized protein XP_001395004.1 2511794 D 5061 CDS An11g10480 84592419 join(2513746..2513800,2514022..2514129,2514293..2514357) VII 1 NT_166526.1 Remark: unusual exon/intron structure for A. niger and short length (75 amino acids).; Title: questionable ORF; uncharacterized protein 2514357 84592419 An11g10480 Aspergillus niger uncharacterized protein XP_059606419.1 2513746 D 5061 CDS An11g10490 4985266 join(2514541..2514627,2514786..2514815,2514944..2515127,2515182..2515321) VII 1 NT_166526.1 Catalytic activity: UBC4 of S. cerevisiae converts ATP + ubiquitin + protein lysine to AMP + pyrophosphate + protein N-ubiquityllysine.; Function: UBC4 of S. cerevisiae catalyzess the covalent attachment of ubiquitin to other proteins,mediating the selective degradation of short-lived and abnormal proteins.; Function: UBC4 of S. cerevisiae contributes to a major portion of the ubiquitin-dependent protein degradation in stressed cells.; Title: strong similarity to ubiquitin conjugating enzyme Ubc4 - Saccharomyces cerevisiae; cytoplasm; See PMID 1311250; See PMID 1651925; See PMID 2154373; See PMID 8381213; See PMID 8391479; uncharacterized protein 2515321 4985266 An11g10490 Aspergillus niger uncharacterized protein XP_001395006.3 2514541 D 5061 CDS An11g10500 84592420 complement(2515783..2516001) VII 1 NT_166526.1 Similarity: the indicated EST extends further along the putative 3'-UTR of the predicted gene.; Title: strong similarity to EST an_2112 -Aspergillus niger; uncharacterized protein 2516001 84592420 An11g10500 Aspergillus niger uncharacterized protein XP_059601680.1 2515783 R 5061 CDS An11g10510 84592421 join(2516109..2516356,2516460..2516809,2516881..2516997,2517040..2517212,2517310..2517433,2517532..2517713) VII 1 NT_166526.1 Function: SRPK2 of M. musculus is involved in the control by phosphorylation of SR splicing factors.; Similarity: the main feature of the predicted ORF is to contain a serine-threonine protein kinase domain; this explains the huge number of BLASTP hits to known and putative members of this broad protein family.; Title: similarity to serine/arginine-rich protein-specific kinase SRPK2 - Mus musculus; See PMID 9446799; uncharacterized protein 2517713 84592421 An11g10510 Aspergillus niger uncharacterized protein XP_059601681.1 2516109 D 5061 CDS An11g10520 4985269 complement(join(2518463..2520104,2520164..2520339)) VII 1 NT_166526.1 Similarity: many other BLASTP hits are due to the relative high content of Ser and Ala.; Similarity: the similarity to the R. capsulatus hypothetical protein involves only the N-terminal fifth of the protein.; Title: similarity to hypothetical conserved protein - Rhodobacter capsulatus; uncharacterized protein 2520339 4985269 An11g10520 Aspergillus niger uncharacterized protein XP_059601682.1 2518463 R 5061 CDS An11g10530 84592422 join(2520673..2520794,2520890..2521105,2521200..2521261,2521372..2521659,2521796..2521832,2521915..2522155) VII 1 NT_166526.1 hypothetical protein 2522155 84592422 An11g10530 Aspergillus niger hypothetical protein XP_059601683.1 2520673 D 5061 CDS An11g10540 4985271 complement(join(2523277..2523753,2523823..2524110)) VII 1 NT_166526.1 Function: mra1 of S. pombe is essential for cell growth and in promoting the mating function; it may be a factor constituting a third pathway regulated by ras1.; Title: strong similarity to ras-associated protein mra1p - Schizosaccharomyces pombe; See PMID 9133664; uncharacterized protein 2524110 4985271 An11g10540 Aspergillus niger uncharacterized protein XP_001395011.3 2523277 R 5061 CDS An11g10550 84592423 complement(join(2525493..2525601,2525692..2525739,2525894..2526057,2526123..2526229,2526322..2526368,2526418..2526516,2526593..2526769,2526805..2526878,2526967..2526987)) VII 1 NT_166526.1 Title: questionable ORF; uncharacterized protein 2526987 84592423 An11g10550 Aspergillus niger uncharacterized protein XP_059601684.1 2525493 R 5061 CDS An11g10560 4985273 join(2527510..2527563,2527690..2527758,2527844..2528118,2528218..2529020,2529060..2529439) VII 1 NT_166526.1 Function: eso1 of S. pombe is essential for the establishment of sister chromatid cohesion during S phase.; Function: eso1 of S. pombe plays a dual role during DNA replication: the C-terminal region acts to establish sister chromatid cohesion, and the N-terminal region presumably catalyzes translesion DNA synthesis when template DNA contains lesions that block regular DNA replication.; Localization: eso1 of S. pombe is probably a nuclear protein.; Similarity: the similarity to eso1 of S. pombe involves only the C-terminal regions of the two proteins.; Title: similarity to sister chromatid cohesion protein eso1p - Schizosaccharomyces pombe; See PMID 10779336; uncharacterized protein 2529439 4985273 An11g10560 Aspergillus niger uncharacterized protein XP_059601685.1 2527510 D 5061 CDS An11g10570 4985275 join(2530383..2530422,2530530..>2530891) VII 1 NT_166526.1 Remark: C-terminally truncated ORF due to contig border.; Similarity: the similarity to the cell wall protein of Y. lipolytica and other proteins is mainly due to low complexity and repetitive elements.; Title: weak similarity to cell wall protein -Yarrowia lipolytica [truncated ORF]; See PMID 8972576; uncharacterized protein 2530891 4985275 An11g10570 Aspergillus niger uncharacterized protein XP_001395015.3 2530383 D 5061 CDS An11g10580 84592424 <2530993..2532003 VII 1 NT_166526.1 Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: N-terminally truncated due to contig border.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: weak similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae [truncated ORF]; See PMID 9987114; See PMID 11152942; See PMID 8710886; See PMID 9383611; uncharacterized protein 2532003 84592424 An11g10580 Aspergillus niger uncharacterized protein XP_059601686.1 2530993 D 5061 CDS An11g10590 4985276 complement(2532872..2534548) VII 1 NT_166526.1 hypothetical protein 2534548 4985276 An11g10590 Aspergillus niger hypothetical protein XP_001395016.3 2532872 R 5061 CDS An11g10600 4985277 complement(join(2534959..2535170,2535270..2536118,2536176..2536471,2536659..2536834,2536933..2537019,2537082..2537126)) VII 1 NT_166526.1 Remark: sucrose transport by SUT1 is linked to the proton electrochemical potential across the plasma membrane.; Title: strong similarity to sucrose-proton transport protein SUT1 - Daucus carota; plasma membrane; See PMID 9847123; uncharacterized protein 2537126 4985277 An11g10600 Aspergillus niger uncharacterized protein XP_059601687.1 2534959 R 5061 CDS An11g10610 4985278 join(2537781..2537826,2537888..2538323,2538411..2538891) VII 1 NT_166526.1 Catalytic activity: catalyzes the alpha-glucosylation of itself on a specific tyrosine residue by UDP-glucose to produce glucosyl-glycogenin and UDP; catalyzes the subsequent alpha-1,4-glucosylation of glucosyl-glycogenin by UDP-glucose to produce glycogen and UDP.; Pathway: the enzyme is involved in glycogen/starch biosynthesis.; Title: similarity to glycogenin glucosyltransferase - Oryctolagus cuniculus; See PMID 1281472; See PMID 3121316; uncharacterized protein 2538891 4985278 An11g10610 Aspergillus niger uncharacterized protein XP_001395018.1 2537781 D 5061 CDS An11g10620 4985279 join(2539986..2540056,2540194..2540965) VII 1 NT_166526.1 Title: weak similarity to membrane-associated proteophosphoglycan - Leishmania major; uncharacterized protein 2540965 4985279 An11g10620 Aspergillus niger uncharacterized protein XP_001395019.1 2539986 D 5061 CDS An11g10630 4985280 join(2542473..2542497,2542613..2542682,2542760..2542831,2542885..2543314,2543391..2544363,2544622..2544827) VII 1 NT_166526.1 Complex: the human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with the large subunit p170.; Remark: eukaryotic initiation factor 3 (eIF3) is a large multisubunit complex that stabilizes the ternary complex, eIF2 x GTP x tRNA(Met)i and promotes mRNA binding to the 40 S ribosomal subunit.; Title: similarity to translation initiation factor 3 complex protein Prt1 - Homo sapiens; See PMID 8995410; uncharacterized protein 2544827 4985280 An11g10630 Aspergillus niger uncharacterized protein XP_059601688.1 2542473 D 5061 CDS An11g10640 84592425 join(2545924..2545928,2546058..2546283) VII 1 NT_166526.1 hypothetical protein 2546283 84592425 An11g10640 Aspergillus niger hypothetical protein XP_059601689.1 2545924 D 5061 CDS An11g10650 4985282 complement(join(2546348..2548262,2548326..2548384)) VII 1 NT_166526.1 Protein sequence is in conflict with the conceptual translation; putative frameshift; hypothetical protein 2548384 4985282 An11g10650 Aspergillus niger hypothetical protein XP_001395022.3 2546348 R 5061 CDS An11g10660 4985283 2548866..2555141 VII 1 NT_166526.1 Function: the bimE gene product is a novel component in the regulation of mitosis.; Phenotype: bimE mutations both cause cells to enter mitosis and prevent them from leaving mitosis.; Title: strong similarity to cell cycle control protein bimE - Aspergillus nidulans; See PMID 1697851; uncharacterized protein 2555141 4985283 An11g10660 Aspergillus niger uncharacterized protein XP_001395023.1 2548866 D 5061 CDS An11g10670 4985284 complement(join(2555482..2555645,2555727..2556930)) VII 1 NT_166526.1 Title: strong similarity to sequence 7 from patent WO0075305 - Candida albicans; uncharacterized protein 2556930 4985284 An11g10670 Aspergillus niger uncharacterized protein XP_059601690.1 2555482 R 5061 CDS An11g10680 4985285 join(2558677..2560091,2560167..2560554) VII 1 NT_166526.1 Remark: similarity to extensin-like proteins, which is based mainly on prolines.; Title: weak similarity to largest subunit of DNA-directed RNA polymerase II RPB1 - Mastigamoeba invertens; uncharacterized protein 2560554 4985285 An11g10680 Aspergillus niger uncharacterized protein XP_001395025.3 2558677 D 5061 CDS An11g10690 4985286 complement(join(2561821..2562438,2562507..2563044,2563112..2563269,2563346..2563633)) VII 1 NT_166526.1 Function: EMK1 is a mitogen-activated protein kinase kinase required for induction of cytokinesis and appressorium formation by host signals in the conidia of Colletotrichum gloeosporioides.; Phenotype: disruption of EMK1 results in the loss of its ability to form appressoria in response to the host's signals and a loss of virulence.; Remark: Colletotrichum gloeosporioides is synonymous with Glomerella cingulata.; Title: strong similarity to MAP kinase kinase EMK1 -Glomerella cingulata; See PMID 10948253; uncharacterized protein 2563633 4985286 An11g10690 Aspergillus niger uncharacterized protein XP_001395026.1 2561821 R 5061 CDS An11g10700 84592426 join(2563772..2563787,2563857..2563921,2563995..2564126) VII 1 NT_166526.1 hypothetical protein 2564126 84592426 An11g10700 Aspergillus niger hypothetical protein XP_059601691.1 2563772 D 5061 CDS An11g10710 4985288 join(<2564292..2565969,2566056..2566306) VII 1 NT_166526.1 Function: SPT6 influences the expression of many genes through effect on chromatin structure.; Function: SPT6 modifies the chromatine structure.; Function: SPT6is involved in transcription elongation.; Remark: truncated ORF due to contig border.; Similarity: shows similarity to the same gene of different species and to several hypothetical proteins.; Title: similarity to transcription elongation protein Spt6 - Saccharomyces cerevisiae [truncated ORF]; nucleus; See PMID 9450930; uncharacterized protein 2566306 4985288 An11g10710 Aspergillus niger uncharacterized protein XP_001395028.1 2564292 D 5061 CDS An11g10720 4985289 join(2567422..2567457,2567570..2570446) VII 1 NT_166526.1 Function: might be involved in sterol synthesis and/or its regulation.; Remark: contains a domain typical for oxysterol-binding proteins.; Similarity: shows similarity to protein that might be involved in sterol synthesis.; Title: strong similarity to hypothetical protein YHR073w - Saccharomyces cerevisiae; uncharacterized protein 2570446 4985289 An11g10720 Aspergillus niger uncharacterized protein XP_001395029.1 2567422 D 5061 CDS An11g10730 4985290 complement(join(2571084..2572329,2572465..2572655)) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein SPBC20F10.03 - Schizosaccharomyces pombe; uncharacterized protein 2572655 4985290 An11g10730 Aspergillus niger uncharacterized protein XP_001395030.1 2571084 R 5061 CDS An11g10740 4985291 complement(join(2573463..2573866,2573966..2574414,2574475..2574695)) VII 1 NT_166526.1 Function: protein of S. cerevisiae is involved in 3'-end processing of the 5. 8S rRNA.; Title: strong similarity to 3-5 exoribonuclease required for 3-end formation of 5.8S rRNA Rrp4 -Saccharomyces cerevisiae; nucleus; See PMID 8600032; See PMID 9463390; See PMID 9482746; uncharacterized protein 2574695 4985291 An11g10740 Aspergillus niger uncharacterized protein XP_059601692.1 2573463 R 5061 CDS An11g10750 4985292 complement(join(2575328..2576153,2576213..2576329,2576391..2576485)) VII 1 NT_166526.1 Similarity: blast hits result from repetitive sequences.; hypothetical protein 2576485 4985292 An11g10750 Aspergillus niger hypothetical protein XP_001395032.1 2575328 R 5061 CDS An11g10760 4985293 2576821..2577936 VII 1 NT_166526.1 Function: NRS1 is involved in processing 20S to 18S rRNA.; Function: proteins containing RNP consensus-sequence RNA-binding domains (CS-RBDs) play diverse roles in many aspects of RNA metabolism.; Similarity: shows strong similarity to known protein of S. cerevisiae nuclear localization sequence binding protein NSR1.; Title: strong similarity to RNA-binding protein rnp24p - Schizosaccharomyces pombe; See PMID 8598051; uncharacterized protein 2577936 4985293 An11g10760 Aspergillus niger uncharacterized protein XP_001395033.1 2576821 D 5061 CDS An11g10770 4985294 join(2579143..2579795,2579819..2581250) VII 1 NT_166526.1 Title: strong similarity to hypothetical conserved protein B8L3.80 - Neurospora crassa; uncharacterized protein 2581250 4985294 An11g10770 Aspergillus niger uncharacterized protein XP_059601693.1 2579143 D 5061 CDS An11g10780 4985295 join(<2582907..2583594,2583645..2583856,2583909..2585174) VII 1 NT_166526.1 Function: might be involved in transcriptional regulation as it is a zinc-finger protein.; Remark: the ORF is truncated due to the border of the contig.; Similarity: no similarity at the aminoterminal part.; Title: similarity to hypothetical conserved protein B8L3.060 - Neurospora crassa [truncated ORF]; uncharacterized protein 2585174 4985295 An11g10780 Aspergillus niger uncharacterized protein XP_059601694.1 2582907 D 5061 CDS An11g10790 4985296 join(2585769..2586077,2586139..2587098) VII 1 NT_166526.1 Function: PON2 catalyzes the hydrolysis of toxic organophosphates.; Function: the absence of paraoxonase activity in turkey and chicken blood and turkey liver indicates that PON2, if expressed, does not hydrolyze paraoxon.; Localization: PON2 is an extracellular enzyme.; Similarity: shows strong similarity to probable arylesterase of N. crassa.; Title: similarity to serum paraoxonase/arylesterase 2 PON2 - Gallus gallus; uncharacterized protein 2587098 4985296 An11g10790 Aspergillus niger uncharacterized protein XP_001395036.1 2585769 D 5061 CDS An11g10800 4985297 complement(2587201..2587866) VII 1 NT_166526.1 Function: isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase catalyses the conversion of isochorismate, in the presence of water, to 2, 3-dihydroxybenzoate and pyruvate.; Similarity: belongs to a family of hydrolase enzymes.; Title: similarity to hypothetical isochorismatase Ta0729 - Thermoplasma acidophilum; uncharacterized protein 2587866 4985297 An11g10800 Aspergillus niger uncharacterized protein XP_001395037.1 2587201 R 5061 CDS An11g10810 4985298 join(2588517..2589591,2589730..2589784,2589913..2590102) VII 1 NT_166526.1 Title: similarity to hypothetical protein B13D24.020 - Neurospora crassa; uncharacterized protein 2590102 4985298 An11g10810 Aspergillus niger uncharacterized protein XP_059601695.1 2588517 D 5061 CDS An11g10820 4985299 complement(join(2590185..2591488,2591551..2591989,2592089..2592183,2592253..2593030)) VII 1 NT_166526.1 Function: might be a sensor/regulator protein harboring pac and pas domains.; Function: wc-1 gene expression is autoregulated and is transcriptionally induced by blue light irradiation.; Function: wc-1 zinc finger domain is able to bind specifically to the promoter of a blue light-regulated gene of Neurospora.; Similarity: shows similarity to central and carboxyterminal part of wc-1.; Title: similarity to central regulator of blue light responses wc-1 - Neurospora crassa; uncharacterized protein 2593030 4985299 An11g10820 Aspergillus niger uncharacterized protein XP_001395039.1 2590185 R 5061 CDS An11g10830 84592427 join(2594074..2594140,2594319..2594374,2594441..2594635) VII 1 NT_166526.1 Similarity: shows only partial similarity to X. laevis protein.; Title: weak similarity to Ig mu chain C region -Xenopus laevis; uncharacterized protein 2594635 84592427 An11g10830 Aspergillus niger uncharacterized protein XP_059601696.1 2594074 D 5061 CDS An11g10840 4985301 join(2594840..2594894,2595231..2595665,2595728..2596050) VII 1 NT_166526.1 Function: Ras-cyclic AMP pathway is required for the formation of hyphae in Y. lipolytica.; Function: protein of Y. lipolytica is homologous to S. cerevisiae RAS2.; Title: strong similarity to GTPase Ras2p - Yarrowia lipolytica; See PMID 11325938; uncharacterized protein 2596050 4985301 An11g10840 Aspergillus niger uncharacterized protein XP_059601697.1 2594840 D 5061 CDS An11g10850 84592428 complement(join(2596446..2596684,2596827..2596931,2597180..2597236,2597324..2597410,2597505..2597632,2597709..2597755)) VII 1 NT_166526.1 hypothetical protein 2597755 84592428 An11g10850 Aspergillus niger hypothetical protein XP_059601698.1 2596446 R 5061 CDS An11g10860 84592429 join(2598216..2598499,2598569..2598599,2598732..2598800,2598919..2599002,2599080..2599115) VII 1 NT_166526.1 hypothetical protein 2599115 84592429 An11g10860 Aspergillus niger hypothetical protein XP_059601699.1 2598216 D 5061 CDS An11g10870 4985304 join(2599850..2599957,2600013..2600110,2600174..2600882) VII 1 NT_166526.1 Title: strong similarity to gene expression regulator An13 from patent WO200257456-A2 - Unclassified organism; uncharacterized protein 2600882 4985304 An11g10870 Aspergillus niger uncharacterized protein XP_059601700.1 2599850 D 5061 CDS An11g10880 84592430 join(2601531..2601719,2601798..2601917,2602006..2602103,2602188..2602236,2602354..2602408,2602511..2602615,2602689..2602753,2602873..2602975,2603075..2603197,2603291..2603374,2603498..2603597,2603663..2603753,2603904..2604029,2604089..2604157) VII 1 NT_166526.1 hypothetical protein 2604157 84592430 An11g10880 Aspergillus niger hypothetical protein XP_059601701.1 2601531 D 5061 CDS An11g10890 4985306 join(2604825..2605324,2605386..2605878) VII 1 NT_166526.1 Function: Aldose 1-epimerase is the enzyme responsible for the anomeric interconversion of D-glucose and other aldoses between their alpha- and beta-forms.; Remark: It has also been shown that, on the basis of extensive sequence similarities, a mutarotase domain seem to be present in the C-terminal half of the fungal GAL10 protein which encodes, in the N-terminal part, for UDP-glucose 4-epimerase.; Similarity: shows partial similarity to carboxyterminal part of the enzyme of S. cervisiae harboring the Aldose 1-epimerase domain.; Title: similarity to UDP-glucose 4-epimerase Gal10 -Saccharomyces cerevisiae; cytoplasm; See PMID 7762304; See PMID 9335593; uncharacterized protein 2605878 4985306 An11g10890 Aspergillus niger uncharacterized protein XP_001395046.1 2604825 D 5061 CDS An11g10900 84592431 complement(join(2608079..2608255,2608421..2608546)) VII 1 NT_166526.1 hypothetical protein 2608546 84592431 An11g10900 Aspergillus niger hypothetical protein XP_059601702.1 2608079 R 5061 CDS An11g10910 4985308 join(2609274..2609429,2609493..2609548,2609613..2610345) VII 1 NT_166526.1 Catalytic activity: Nicotinate D-ribonucleotide + diphosphate + CO(2) <=> pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate; Function: the H. sapiens homolog QPRTase is a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide (NAD) pathway.; Title: strong similarity to nicotinate-nucleotide pyrophosphorylase (carboxylating) QPRTase - Homo sapiens; uncharacterized protein 2610345 4985308 An11g10910 Aspergillus niger uncharacterized protein XP_001395048.1 2609274 D 5061 CDS An11g10920 4985309 complement(join(2610771..2613602,2613659..2614135)) VII 1 NT_166526.1 Function: the A. nidulans homolog aspB is an essential gene that encodes a septin, putative cytoskeletal proteins involved in cytokinesis and morphogenesis. aspB affects nuclear distribution in hyphae and specifically blocks conidiophore development at the metula stage when mutant.; Similarity: most fungal septins belong to one of four orthologous classes.; Title: strong similarity to septin apsB -Aspergillus nidulans; See PMID 9126618; uncharacterized protein 2614135 4985309 An11g10920 Aspergillus niger uncharacterized protein XP_001395049.3 2610771 R 5061 CDS An11g10930 4985310 complement(join(2616762..2618653,2618716..2621176)) VII 1 NT_166526.1 Function: the H. sapiens homolog p200 ARF-GEP1 is a guanine nucleotide-exchange protein (GEP) which activates ADP-ribosylation factors (ARFs), approximately 20-kDa guanine nucleotide-binding proteins that play an important role in intracellular vesicular trafficking, through accelerated replacement of bound GDP with GTP.; Golgi; Repression: Human p200 ARF-GEP1 is inhibited by brefeldin A (BFA), a fungal metabolite that blocks protein secretion and causes apparent disintegration of the Golgi structure.; Similarity: H. sapiens p200 ARF-GEP1 is a ubiquitously expressed guanine nucleotide exchange factor of the Sec7 domain family, which affects protein traffic and Golgi morphology.; Title: strong similarity to p200 protein ARF-GEP1 -Homo sapiens; uncharacterized protein 2621176 4985310 An11g10930 Aspergillus niger uncharacterized protein XP_001395050.1 2616762 R 5061 CDS An11g10940 84592432 join(2621249..2621333,2621429..2621487,2621569..2621620,2621693..2621744,2621909..2621972,2622077..2622306,2622370..2622479,2622566..2622854,2622942..2623086) VII 1 NT_166526.1 hypothetical protein 2623086 84592432 An11g10940 Aspergillus niger hypothetical protein XP_059601703.1 2621249 D 5061 CDS An11g10950 4985312 join(2623824..2623851,2623948..2624285,2624341..2624751) VII 1 NT_166526.1 Function: R. norvegicus UNCL is a RNA binding transmembrane protein.; Similarity: the R. norvegicus homolog UNCL shows homologies C. elegans unc-50 gene product.; Title: strong similarity to unc-50 related protein UNCL - Rattus norvegicus; nucleus; uncharacterized protein 2624751 4985312 An11g10950 Aspergillus niger uncharacterized protein XP_059601704.1 2623824 D 5061 CDS An11g10960 4985313 complement(join(2625105..2625806,2625887..2625954,2626024..2626069)) VII 1 NT_166526.1 Title: weak similarity to protein fragment SEQ ID NO:13312 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 2626069 4985313 An11g10960 Aspergillus niger uncharacterized protein XP_059601705.1 2625105 R 5061 CDS An11g10970 4985314 complement(join(2626666..2627738,2627772..2628129)) VII 1 NT_166526.1 Function: MCTs are needed for rapid transport of monocarboxylates such as lactate and pyruvate.; Similarity: the ORF shows similarity to several carboxylate transporters.; Similarity: the closest homolog of the ORF, the S. cerevisiae YOR306c protein, encodes one of four putative monocarboxylate transporters (MCTs) in the yeast genome.; Title: similarity to monocarboxylate transporter MCT2 - Mesocricetus auratus; uncharacterized protein 2628129 4985314 An11g10970 Aspergillus niger uncharacterized protein XP_059601706.1 2626666 R 5061 CDS An11g10980 84592433 join(2628326..2628516,2628669..2629122) VII 1 NT_166526.1 hypothetical protein 2629122 84592433 An11g10980 Aspergillus niger hypothetical protein XP_059601707.1 2628326 D 5061 CDS An11g10990 4985316 complement(join(2630275..2630444,2630517..2632761,2632846..2632959)) VII 1 NT_166526.1 Catalytic activity: Trehalose 6-phosphate + H(2)O <=> trehalose + phosphate.; Complex: the S. cerevisiae homolog TPS2 encodes the 100-kDa subunit of the trehalose-6-phosphate synthase/phosphatase complex.; Function: S. cerevisiae TPS2 codes for the structural gene of the trehalose-6-phosphate phosphatase.; Induction: S. cerevisiae Tps2p expression is induced under heat-shock conditions.; Pathway: trehalose biosynthesis.; Title: strong similarity to trehalose-6-phosphate phosphatase TPP from patent WO200116357-A2 - Saccharomyces cerevisiae; uncharacterized protein 2632959 4985316 An11g10990 Aspergillus niger uncharacterized protein XP_001395056.3 2630275 R 5061 CDS An11g11000 4985317 join(2635196..2635402,2635499..2635554,2635587..2637435) VII 1 NT_166526.1 Function: the H. sapiens homolog TRF4 is required for sister chromatid cohesion and encodes a DNA polymerase with beta-polymerase-like properties.; Title: similarity to DNA polymerase kappa TRF4 -Homo sapiens; nucleus; uncharacterized protein 2637435 4985317 An11g11000 Aspergillus niger uncharacterized protein XP_001395057.3 2635196 D 5061 CDS An11g11010 4985318 complement(join(2637905..2637911,2637971..2638039,2638108..2643512)) VII 1 NT_166526.1 Catalytic activity: a phosphatidylcholine + H(2)O <=> choline + a phosphatidate.; Function: The activation of phospholipase D (PLD) is believed to play an important role in the regulation of cell function and cell fate. The function of the S. cerevisiae homolog Pld1p, while essential for meiosis, is dispensable for vegetative growth.; Localization: different PLD isoforms are localized in distinct cellular organelles, where they are likely to serve diverse functions in signal transduction, membrane vesicle trafficking and cytoskeletal dynamics.; Remark: an alternative gene name for the S. cerevisiae homolog PLD1 is SPO14.; Similarity: the homolog Pld1p is sole member of the phosphatidylcholine-specific phospholipase D gene family in S. cerevisiae.; Title: strong similarity to phospholipase D Pld1 -Saccharomyces cerevisiae; uncharacterized protein 2643512 4985318 An11g11010 Aspergillus niger uncharacterized protein XP_001395058.1 2637905 R 5061 CDS An11g11020 4985319 join(2645179..2645542,2645613..2646334) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein 12F11.200 - Neurospora crassa; uncharacterized protein 2646334 4985319 An11g11020 Aspergillus niger uncharacterized protein XP_001395059.1 2645179 D 5061 CDS An11g11030 4985320 complement(join(2647025..2647243,2647441..2647639,2647791..2647822)) VII 1 NT_166526.1 Phenotype: mutations in L28 of S. cerevisiae can lead to resistance to cycloheximide, an inhibitor of eukaryotic protein synthesis.; Remark: L28 of S. cerevisiae is also called L28,CYH2, G3101, YGL103w, or YL29.; Similarity: the ORF overlaps with the A. niger EST seq id no:3836 of patent WO200056762-A2.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L28 - Saccharomyces cerevisiae; cytoplasm; See PMID 6304624; 60S ribosomal protein uL15 2647822 4985320 An11g11030 Aspergillus niger 60S ribosomal protein uL15 XP_001395060.1 2647025 R 5061 CDS An11g11040 4985321 complement(join(2648229..2648930,2649009..2649179,2649234..2650598,2650661..2650827,2650880..2650970,2651138..2651142,2651198..2651321)) VII 1 NT_166526.1 Function: the S. cerevisiae homolog CHL1 is a helicase required for maintenance of the high fidelity of chromosome transmission during mitosis and wild-type levels of meiotic recombination as well as spore viability.; Title: strong similarity to helicase Chl1 -Saccharomyces cerevisiae; nucleus; uncharacterized protein 2651321 4985321 An11g11040 Aspergillus niger uncharacterized protein XP_059601708.1 2648229 R 5061 CDS An11g11050 4985322 join(2653432..2653463,2653651..2654368,2654424..2654543,2654597..2655967) VII 1 NT_166526.1 Function: SKT5 of S. cerevisiae is an enzyme activator involved in the cell wall chitin biosynthesis probably by acting as a post-translational regulator of chitin synthase III activity, and seems to influence cytokinesis as well as osmotic response.; Function: SKT5 of S. cerevisiae is involved in protoplast regeneration and killer toxin resistance.; Remark: SKT5 of S. cerevisiae is also called CAL2,CHS4, CSD4 or YBL061C.; Similarity: the ORF is 93 amino acids shorter at the N-terminus than SKT5 of S. cerevisiae and the homology is restricted to the inner part of both proteins.; Title: strong similarity to enzyme activator protein Skt5 - Saccharomyces cerevisiae; See PMID 1532231; See PMID 7764021; See PMID 8257107; uncharacterized protein 2655967 4985322 An11g11050 Aspergillus niger uncharacterized protein XP_059601709.1 2653432 D 5061 CDS An11g11060 4985324 join(2656571..2656616,2656690..2656731,2656954..2657028,2657095..2657157,2657228..2657637,2657756..2657815) VII 1 NT_166526.1 Function: meu13 of S. pombe is believed to be a molecule that is required for proper homologous chromosome pairing during meiosis by contributing to pairing through a recombination-independent mechanism.; Remark: meu13 of S. pombe is also called SPAC222. 15 or SPAC821. 01.; Similarity: additionally, the ORF shows similarity to TBP-1 interacting protein of M. musculus.; Similarity: the ORF overlaps with A. niger EST SEQ ID NO:4271, database PATENTDNA:AAF11748.; Title: similarity to meiosis-specific protein meu13p - Schizosaccharomyces pombe; nucleus; See PMID 11447128; uncharacterized protein 2657815 4985324 An11g11060 Aspergillus niger uncharacterized protein XP_059601710.1 2656571 D 5061 CDS An11g11070 84592434 join(2659334..2659448,2659638..2659759,2659867..2661282) VII 1 NT_166526.1 Remark: the S. pombe homolog scp3 is related to spindle poison sensitivity.; Title: strong similarity to hypothetical protein scp3p - Schizosaccharomyces pombe; uncharacterized protein 2661282 84592434 An11g11070 Aspergillus niger uncharacterized protein XP_059601711.1 2659334 D 5061 CDS An11g11080 4985325 complement(join(2662573..2663568,2663648..2664919,2665001..2665069,2665140..2665302,2665436..2665609,2665884..2665930)) VII 1 NT_166526.1 Function: S. cerevisiae Rsc1p is subunit of the RSC-complex, an essential 15 protein nucleosome-remodeling complex, and is required for transcriptional control.; Remark: an alternative gene name for the S. cerevisiae homolog RSC1 is YGR056w.; Title: strong similarity to protein Rsc1 -Saccharomyces cerevisiae; nucleus; uncharacterized protein 2665930 4985325 An11g11080 Aspergillus niger uncharacterized protein XP_001395065.3 2662573 R 5061 CDS An11g11090 4985326 join(2666162..2667066,2667213..2667252) VII 1 NT_166526.1 Title: strong similarity to hypothetical protein SPAC24C9.14 - Schizosaccharomyces pombe; uncharacterized protein 2667252 4985326 An11g11090 Aspergillus niger uncharacterized protein XP_001395066.3 2666162 D 5061 CDS An11g11100 4985327 complement(join(2667502..2668185,2668240..2668300,2668367..2668826,2668927..2669197)) VII 1 NT_166526.1 Function: S. pombe hsk1 is required for G1/S transition.; Remark: shows strong similarity to cell cycle protein kinase hsk1 - Schizosaccharomyces pombe.; Title: strong similarity to cell cycle protein kinase hsk1p - Schizosaccharomyces pombe; uncharacterized protein 2669197 4985327 An11g11100 Aspergillus niger uncharacterized protein XP_001395067.1 2667502 R 5061 CDS An11g11110 4985328 join(2670058..2670293,2670379..2670890,2670950..2671073,2671133..2671274,2671330..2673708,2673781..2673954) VII 1 NT_166526.1 Complex: is part of the five-member condensin complex, each of which is essential for mitotic condensation.; Title: strong similarity to condensin complex component cnd1p - Schizosaccharomyces pombe; uncharacterized protein 2673954 4985328 An11g11110 Aspergillus niger uncharacterized protein XP_059601712.1 2670058 D 5061 CDS An11g11120 4985329 complement(join(2674711..2675646,2675711..2675770,2675832..2675901,2675961..2676000,2676084..2676160,2676254..2676339)) VII 1 NT_166526.1 Similarity: the S. pombe homolog SPBC646. 08c has similarity to proteins involved in ergosterol biosynthesis.; Title: strong similarity to hypothetical protein involved in ergosterol biosynthesis SPBC646.08c -Schizosaccharomyces pombe; uncharacterized protein 2676339 4985329 An11g11120 Aspergillus niger uncharacterized protein XP_001395069.1 2674711 R 5061 CDS An11g11130 4985330 complement(join(2677854..2678395,2678454..2678540,2678580..2678638,2678686..2678867,2678926..2679025,2679081..2679175,2679254..2679292,2679334..2679345)) VII 1 NT_166526.1 Complex: S. pombe UCH is associated with the proteasome by its C-terminal extension.; Function: the S. pombe homolog UCH belongs to the family of deubiquitinating enzymes (DUBs) and encodes a ubiquitin carboxyterminal hydrolase.; Title: strong similarity to 26S proteasome-associated ubiquitin carboxyl-terminal hydrolase uch2p - Schizosaccharomyces pombe; uncharacterized protein 2679345 4985330 An11g11130 Aspergillus niger uncharacterized protein XP_059601713.1 2677854 R 5061 CDS An11g11140 4985331 join(2680516..2680950,2681006..2681154,2681214..2684195,2684249..2684450) VII 1 NT_166526.1 Complex: S. cerevisae Pom152 is part of the nuclear pore complex (NPC).; Function: the S. cerevisiae homolog Pom152p is an abundant but nonessential nucleoporin.; Localization: S. cerevisiae Pom152p is a type II integral membrane protein with N-terminal region on pore side and C-terminal region in the cisternae.; Title: strong similarity to nuclear pore membrane protein Pom152 - Saccharomyces cerevisiae; nucleus; uncharacterized protein 2684450 4985331 An11g11140 Aspergillus niger uncharacterized protein XP_001395071.1 2680516 D 5061 CDS An11g11150 4985332 complement(2684621..2687971) VII 1 NT_166526.1 Remark: the S. cerevisiae homolog YGR090w is an essential gene.; Title: strong similarity to hypothetical protein YGR090w from patent WO200039342-A2 - Saccharomyces cerevisiae; uncharacterized protein 2687971 4985332 An11g11150 Aspergillus niger uncharacterized protein XP_059601714.1 2684621 R 5061 CDS An11g11160 4985333 join(2689101..2689145,2689292..2690708,2690802..2690985,2691043..2691085,2691166..2691285) VII 1 NT_166526.1 Catalytic activity: O-succinyl-L-homoserine + L-cysteine <=> cystathionine + succinate.; Complex: the N. crassa homolog met-7+, together with met-3+, is required to form a functional cystathionine-gamma-synthase (CGS).; Function: CGS catalyses the first reaction specific for methionine biosynthesis.; Title: strong similarity to O-succinylhomoserine (thiol)-lyase met-7 chain - Neurospora crassa; uncharacterized protein 2691285 4985333 An11g11160 Aspergillus niger uncharacterized protein XP_059601715.1 2689101 D 5061 CDS An11g11170 4985334 2692273..2692878 VII 1 NT_166526.1 Function: the S. cerevisiae homolog YmL20 encodes for a mitochondrial large subunit ribosomal protein.; Title: strong similarity to mitochondrial ribosomal protein of the large subunit Yml20 - Saccharomyces cerevisiae; localisation:mitochondrion; mitochondrial 54S ribosomal protein mL58 2692878 4985334 An11g11170 Aspergillus niger mitochondrial 54S ribosomal protein mL58 XP_001395074.1 2692273 D 5061 CDS An11g11180 4985335 join(2693565..2693596,2693734..2693765,2693825..2693892,2693958..2695075,2695146..2695329) VII 1 NT_166526.1 Similarity: the ORF encoded protein shows strong similarity to expressed sequence tag an_3583 from Aspergillus niger.; Title: strong similarity to hypothetical protein encoded by SPBC1198.08 - Schizosaccharomyces pombe; uncharacterized protein 2695329 4985335 An11g11180 Aspergillus niger uncharacterized protein XP_001395075.1 2693565 D 5061 CDS An11g11190 4985336 join(2696047..2696127,2696179..2696585,2696642..2697143,2697182..2697439,2697496..2698055,2698099..2698201,2698260..2698525,2698580..2699236,2699286..2699388,2699448..2699606,2699661..2699800,2699853..2699928,2699977..2700075) VII 1 NT_166526.1 Function: the S. pombe homolog rad18p is involved in both UV-induced lesions and double-stranded breaks. Furthermore rad18p is required to maintain cell cycle arrest in the presence of DNA damage, and failure of this leads to highly aberrant mitoses.; Title: strong similarity to DNA repair protein rad18p - Schizosaccharomyces pombe; uncharacterized protein 2700075 4985336 An11g11190 Aspergillus niger uncharacterized protein XP_059601716.1 2696047 D 5061 CDS An11g11200 84592435 complement(join(2700480..2700586,2700616..2700658)) VII 1 NT_166526.1 hypothetical protein 2700658 84592435 An11g11200 Aspergillus niger hypothetical protein XP_059601717.1 2700480 R 5061 CDS An11g11210 4985338 join(2701491..2701534,2701596..2701668,2701727..2702323,2702380..2703183) VII 1 NT_166526.1 Function: the S. pombe homolog ste13 encodes a RNA helicase that is essential for nitrogen starvation-induced G1 arrest and initiation of sexual development.; Title: strong similarity to ATP-dependent RNA helicase ste13p - Schizosaccharomyces pombe; nucleus; uncharacterized protein 2703183 4985338 An11g11210 Aspergillus niger uncharacterized protein XP_001395078.1 2701491 D 5061 CDS An11g11220 84592436 join(2703904..2703954,2704035..2704196,2704252..2704326) VII 1 NT_166526.1 hypothetical protein 2704326 84592436 An11g11220 Aspergillus niger hypothetical protein XP_059601718.1 2703904 D 5061 CDS An11g11230 4985340 join(2704929..2704961,2705024..2705078,2705131..2705151,2705209..2705340,2705414..2705561,2705667..2705924,2705987..2706022,2706075..2706224,2706282..2706339) VII 1 NT_166526.1 Function: CTP1 from S. cerevisiae is involved in citrate transport across the inner mitochondrial membrane.; Remark: strong similarity to Acetyl CoA transport protein orf14 of patent WO200037629-A2.; Similarity: the ORF encoded protein shows also strong similarity to expressed sequence tag seq id no:3910 of patent WO200056762-A2 from Aspergillus niger.; Title: strong similarity to citrate transport protein Ctp1 - Saccharomyces cerevisiae; localisation:mitochondrion; uncharacterized protein 2706339 4985340 An11g11230 Aspergillus niger uncharacterized protein XP_001395080.1 2704929 D 5061 CDS An11g11240 4985341 complement(join(2706507..2707523,2707576..2707771,2707888..2708063)) VII 1 NT_166526.1 Function: the K. lactis homolog MRF1 encodes the mitochondrial peptide chain release factor mRF-1 which is involved in termination of mitochondrial protein synthesis.; Title: strong similarity to translation releasing factor RF-1 precursor MRF1 - Kluyveromyces lactis; localisation:mitochondrion; uncharacterized protein 2708063 4985341 An11g11240 Aspergillus niger uncharacterized protein XP_059601719.1 2706507 R 5061 CDS An11g11250 4985342 join(2708393..2709226,2709269..2709370,2709440..2710027) VII 1 NT_166526.1 Function: P58 from H. sapiens is a cellular protein that is activated during influenza virus infection to down-regulate the activity of PKR.; Similarity: the ORF encoded protein shows also strong similarity to expressed sequence tag an_2388 from Aspergillus niger.; Title: strong similarity to interferon-induced double-stranded RNA-activated protein kinase inhibitor P58 - Homo sapiens; See PMID 8666242; uncharacterized protein 2710027 4985342 An11g11250 Aspergillus niger uncharacterized protein XP_059601720.1 2708393 D 5061 CDS An11g11260 4985343 complement(join(2710296..2710913,2711135..2711236)) VII 1 NT_166526.1 Catalytic activity: S-adenosyl-L-methionine + protein L-beta-aspartate <=> S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester.; Function: the M. musculus homolog PCMT1 encodes a D-aspartate O-methyltransferase which is involved in protein methylation.; Title: strong similarity to protein-L-isoaspartate(D-aspartate) O-methyltransferase PCMT1 - Mus musculus; uncharacterized protein 2711236 4985343 An11g11260 Aspergillus niger uncharacterized protein XP_001395083.3 2710296 R 5061 CDS An11g11270 84592437 join(2712260..2712425,2712485..2713209) VII 1 NT_166526.1 hypothetical protein 2713209 84592437 An11g11270 Aspergillus niger hypothetical protein XP_059601721.1 2712260 D 5061 CDS An11g11280 4985345 complement(join(2713472..2713516,2713576..2713647,2713722..2713789,2713843..2713897,2713956..2714015,2714073..2714465,2714548..2714892,2714978..2715033,2715087..2715158,2715223..2715281,2715341..2715525)) VII 1 NT_166526.1 Catalytic activity: Succinyl-CoA + dihydrolipoamide <=> CoA + S-succinyldihydrolipoamide.; Function: the S. cerevisiae homolog Kgd2p is a subunit of the 2-oxoglutarate dehydrogenase (alpha-ketoglutarate dehydrogenase) complex KE2. KE2 catalyzes the overall conversion of 2-oxoglutarate to succinyl-coa & co2.; Remark: strong similarity to dihydrolipoamide succinyltransferase Kgd2p - S. cerevisiae.; Title: strong similarity to dihydrolipoamide succinyltransferase kgd2 - Aspergillus fumigatus; localisation:mitochondrion; uncharacterized protein 2715525 4985345 An11g11280 Aspergillus niger uncharacterized protein XP_001395085.1 2713472 R 5061 CDS An11g11290 4985346 join(2715789..2715841,2716092..2716228,2716259..2716288,2716320..2716367,2716426..2716471,2716498..2716510) VII 1 NT_166526.1 Title: similarity to hypothetical protein CX157 -Homo sapiens; uncharacterized protein 2716510 4985346 An11g11290 Aspergillus niger uncharacterized protein XP_059601722.1 2715789 D 5061 CDS An11g11300 4985347 complement(join(2716934..2716992,2717045..2717248,2717301..2717389,2717456..2717508)) VII 1 NT_166526.1 Gene-ID: httA; Similarity: shows strong similarity to superfamily of histone H2A proteins.; nucleus; histone H2A httA-Aspergillus niger 2717508 httA 4985347 httA Aspergillus niger histone H2A httA-Aspergillus niger XP_001395087.1 2716934 R 5061 CDS An11g11310 4985348 join(2718148..2718322,2718377..2718448,2718504..2718591,2718642..2718732) VII 1 NT_166526.1 Similarity: shows strong similarity to superfamily of histone H2B proteins.; Similarity: the ORF shows strong similarity to expressed sequence tag an_2054 from Aspergillus niger.; Title: strong similarity to histone H2B -Aspergillus nidulans; See PMID 2274040; uncharacterized protein 2718732 4985348 An11g11310 Aspergillus niger uncharacterized protein XP_001395088.1 2718148 D 5061 CDS An11g11320 4985349 complement(join(2719080..2719437,2719493..2719720,2719780..2719948,2719999..2720307,2720389..2720539)) VII 1 NT_166526.1 Complex: Aut2p and Aut7p interact physically. Aut7p is attached to microtubules via Aut2p, which interacts with tubulins Tub1p and Tub2p.; Function: Aut2p is a member of a ubiquitin-like system required for the autophagy and cytoplasm to vacuole targeting pathways. Aut2p has a proteolytic activity and activates the ubiquitin-like modifyer Aut7p by cleaving the carboxy-terminal arginine of nascent Aut7p.; Remark: alternative gene names for the S. cerevisiae homolog AUT2 are APG4 and YNL223w.; Title: strong similarity to protein involved in autophagy Aut2 - Saccharomyces cerevisiae; cytoplasm; uncharacterized protein 2720539 4985349 An11g11320 Aspergillus niger uncharacterized protein XP_001395089.1 2719080 R 5061 CDS An06g00010 84591160 join(<1..110,186..236,276..887,1006..3115) VIII 1 NT_166522.1 Remark: ORF 5'truncated due to end of contig.; Similarity: Regionally restricted similarity to ankyrin from many organisms.; Title: similarity to polypeptide SEQ ID NO:13410 from patent WO200171042-A2 - Drosophila melanogaster; uncharacterized protein 3115 84591160 An06g00010 Aspergillus niger uncharacterized protein XP_059606908.1 1 D 5061 CDS An06g00020 84591161 join(3670..3946,4044..4090) VIII 1 NT_166522.1 Similarity: Similarity to a short sequence motif from glutamate-5-semialdehyde dehydrogenase (EC 1. 2. 1. 41) Corynebacterium glutamicum.; hypothetical protein 4090 84591161 An06g00020 Aspergillus niger hypothetical protein XP_059606909.1 3670 D 5061 CDS An06g00030 4981019 6085..7248 VIII 1 NT_166522.1 Title: similarity to hypothetical protein C29F5.1 -Caenorhabditis elegans; uncharacterized protein 7248 4981019 An06g00030 Aspergillus niger uncharacterized protein XP_059606910.1 6085 D 5061 CDS An06g00040 84591162 join(7705..7734,8032..8126,8188..8197,8258..8320) VIII 1 NT_166522.1 Title: questionable ORF; uncharacterized protein 8320 84591162 An06g00040 Aspergillus niger uncharacterized protein XP_059606911.1 7705 D 5061 CDS An06g00050 84591163 complement(join(8691..8705,8781..9170)) VIII 1 NT_166522.1 Similarity: Similarity to a short sequence region of acz gene for aczonin from Homo sapiens.; hypothetical protein 9170 84591163 An06g00050 Aspergillus niger hypothetical protein XP_059606912.1 8691 R 5061 CDS An06g00060 84591164 complement(join(10995..11032,11217..11329,11453..11499,11576..12189,12266..12803)) VIII 1 NT_166522.1 Similarity: Similarity to other proteins is based on repetetive sequence regions.; hypothetical protein 12803 84591164 An06g00060 Aspergillus niger hypothetical protein XP_059603759.1 10995 R 5061 CDS An06g00090 10098299 15925..20337 VIII 1 NT_166522.1 Function: Tto1 can transpose autonomously through reverse transcription.; Title: strong similarity to retrotransposon Tto1 -Nicotiana tabacum; See PMID 8624443; uncharacterized protein 20337 10098299 An06g00090 Aspergillus niger uncharacterized protein XP_003188695.2 15925 D 5061 CDS An06g00110 84591165 complement(join(23809..23833,24104..24193,24253..24386,24443..24562,24663..24921,25027..26354)) VIII 1 NT_166522.1 Similarity: Weak similarity to parts of a hypothetical urea active transporter from Schizosaccharomyces pombe.; hypothetical protein 26354 84591165 An06g00110 Aspergillus niger hypothetical protein XP_059603760.1 23809 R 5061 CDS An06g00120 4981011 complement(join(27876..27934,28052..29408)) VIII 1 NT_166522.1 Title: strong similarity to FLO11 gene expression regulator At14 from patent WO200257456-A2 - Unclassified organism; uncharacterized protein 29408 4981011 An06g00120 Aspergillus niger uncharacterized protein XP_059603761.1 27876 R 5061 CDS An06g00130 4981018 join(29964..30335,30389..31186) VIII 1 NT_166522.1 Catalytic activity: NADH + acceptor = NAD(+) + reduced acceptor.; Cofactor: This flavoprotein enzyme contains one noncovalently bound FAD per polypeptide chain.; Function: Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation.; Induction: Expressed aerobically and repressed in fermentation.; Localization: Membrane.; Similarity: the ORF shows similarity to several different reductases.; Title: similarity to NADH dehydrogenase ndh -Escherichia coli; See PMID 7020757; See PMID 6265208; uncharacterized protein 31186 4981018 An06g00130 Aspergillus niger uncharacterized protein XP_001390841.1 29964 D 5061 CDS An06g00140 84591166 complement(join(32574..32680,32881..32911)) VIII 1 NT_166522.1 hypothetical protein 32911 84591166 An06g00140 Aspergillus niger hypothetical protein XP_059603762.1 32574 R 5061 CDS An06g00150 4981022 join(33708..34147,34207..35482) VIII 1 NT_166522.1 Similarity: Most blast hits are due to repetetive sequence elements.; Similarity: Some blast hits to mucins.; Title: similarity to hypothetical protein encoded by An11g04090 - Aspergillus niger; uncharacterized protein 35482 4981022 An06g00150 Aspergillus niger uncharacterized protein XP_059603763.1 33708 D 5061 CDS An06g00160 4981010 complement(join(35888..36210,36288..36338,36392..36506)) VIII 1 NT_166522.1 Remark: binB is induced by the antibiotic bafilomycin.; Title: weak similarity to hypothetical cell wall protein binB - Aspergillus nidulans; uncharacterized protein 36506 4981010 An06g00160 Aspergillus niger uncharacterized protein XP_001390844.1 35888 R 5061 CDS An06g00170 4981013 38658..40271 VIII 1 NT_166522.1 Function: Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides,including galactose oligosaccharides, galactomannans and galactolipids.; Gene-ID: aglA; Mapping: aglA from A. niger is mapped to chromosome VIII (LG VIII); see list from DSM, PUBMED 8041364.; Remark: This ORF has some differences in its nucleotide sequence compared to aglA from the databanks resulting in some aa exchanges.; Remark: This ORF is N-terminally 8 aa shorter than aglA from the databanks.; Remark: in the SWISSPROT entry P56526 the alpha-glucosidases aglU from A. niger is also wrongly termed as aglA.; See PMID 1320186; alpha-galactosidase aglA-Aspergillus niger 40271 aglA 4981013 aglA Aspergillus niger alpha-galactosidase aglA-Aspergillus niger XP_001390845.1 38658 D 5061 CDS An06g00180 4981008 join(41273..41341,41416..41476,41509..41597,41637..41741,41780..41826,41903..41918) VIII 1 NT_166522.1 hypothetical protein 41918 4981008 An06g00180 Aspergillus niger hypothetical protein XP_059603764.1 41273 D 5061 CDS An06g00190 4981033 join(42822..43717,43767..43908,43959..44052,44111..44414,44471..44822) VIII 1 NT_166522.1 Remark: The late-infantile form of neuronal ceroid lipofuscinosis (LINCL) is a progressive and ultimately fatal neurodegenerative disease of childhood. The defective gene in this hereditary disorder, CLN2, encodes a recently identified lysosomal pepstatin-insensitive acid protease.; Title: strong similarity to lysosomal pepstatin insensitive protease CLN2 - Homo sapiens; See PMID 10330339; See PMID 10428067; uncharacterized protein 44822 4981033 An06g00190 Aspergillus niger uncharacterized protein XP_001390847.1 42822 D 5061 CDS An06g00200 4981014 complement(join(45843..46672,46765..46963)) VIII 1 NT_166522.1 Similarity: Regionally restricted similarity to an alpha-amylase and a cellulase gene.; hypothetical protein 46963 4981014 An06g00200 Aspergillus niger hypothetical protein XP_059603765.1 45843 R 5061 CDS An06g00210 4981030 complement(join(47773..48358,48422..48746,48799..49042)) VIII 1 NT_166522.1 Remark: sequence 379 is one of the corynebacterium glutamicum genes encoding proteins involved in homeostasis RT and adaptation.; Title: similarity to sequence 379 from patent WO0100842-A - Corynebacterium glutamicum; uncharacterized protein 49042 4981030 An06g00210 Aspergillus niger uncharacterized protein XP_059603766.1 47773 R 5061 CDS An06g00220 84591167 complement(join(49609..49901,50021..50145,50275..50435)) VIII 1 NT_166522.1 hypothetical protein 50435 84591167 An06g00220 Aspergillus niger hypothetical protein XP_059603767.1 49609 R 5061 CDS An06g00230 4981017 50882..51739 VIII 1 NT_166522.1 Catalytic activity: S-Adenosyl-L-methionine + 3-Demethylubiquinone-9 = S-Adenosyl-L-homocysteine + Ubiquinone-9.; Similarity: ORF is similar to several methyl transferases.; Title: similarity to 3-demethylubiquinone-9 3-O-methyltransferase ubiG - Escherichia coli; See PMID 8703953; uncharacterized protein 51739 4981017 An06g00230 Aspergillus niger uncharacterized protein XP_001390851.1 50882 D 5061 CDS An06g00240 84591168 complement(join(52446..52765,52833..53193)) VIII 1 NT_166522.1 Similarity: shows similarity only against N-terminal half of An02g01340 .; Title: similarity to hypothetical protein encoded by An02g01340 - Aspergillus niger; uncharacterized protein 53193 84591168 An06g00240 Aspergillus niger uncharacterized protein XP_059603768.1 52446 R 5061 CDS An06g00250 84591169 complement(join(55991..56128,56168..56176)) VIII 1 NT_166522.1 Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 56176 84591169 An06g00250 Aspergillus niger uncharacterized protein XP_059603769.1 55991 R 5061 CDS An06g00260 4981003 join(56883..57252,57324..57400,57454..58711,58765..58967) VIII 1 NT_166522.1 Function: S. cerevisiae HXT5 is one of 7 metabolically relevant hexose transporters.; Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs an_3229, 2191 and 3169.; Similarity: S. cerevisiae HXT5 is a member of the superfamily of monosaccharide facilitators.; Title: strong similarity to hexose transporter Hxt5 - Saccharomyces cerevisiae; plasma membrane; See PMID 7651133; uncharacterized protein 58967 4981003 An06g00260 Aspergillus niger uncharacterized protein XP_001390854.1 56883 D 5061 CDS An06g00270 4981026 complement(join(59568..59675,59733..60277,60427..60757)) VIII 1 NT_166522.1 Title: similarity to hypothetical protein encoded by An07g06270 - Aspergillus niger; uncharacterized protein 60757 4981026 An06g00270 Aspergillus niger uncharacterized protein XP_059603770.1 59568 R 5061 CDS An06g00280 4981009 complement(join(61438..62217,62283..62396)) VIII 1 NT_166522.1 Title: strong similarity to hypothetical protein YBR096w - Saccharomyces cerevisiae; uncharacterized protein 62396 4981009 An06g00280 Aspergillus niger uncharacterized protein XP_001390856.1 61438 R 5061 CDS An06g00290 4981024 join(63683..63909,63977..64099,64151..64842,64894..66161,66219..66351,66422..66568,66648..67042) VIII 1 NT_166522.1 Function: A. niger lacA is a thermostable beta-galactosidase, involved in lactose-utilisation.; Localization: A. niger lacA is a secreted protein.; Title: strong similarity to beta-galactosidase lacA - Aspergillus niger; extracellular/secretion proteins; See PMID 1368193; uncharacterized protein 67042 4981024 An06g00290 Aspergillus niger uncharacterized protein XP_059603771.1 63683 D 5061 CDS An06g00300 4981025 complement(join(67620..67850,67904..68160,68214..68364,68394..68511,68576..68693,68754..68759,68833..68882,68957..69045)) VIII 1 NT_166522.1 Function: N. tabacum TABPPT8 is a phosphoenolpyruvate/phosphate antiporter.; Function: N. tabacum TABPPT8 mediates plastidic transport of inorganic phosphate in exchange with C3 compounds phosphorylated at C-atom 2, particularly phosphoenolpyruvate.; Localization: N. tabacum TABPPT8 localises to plastides in green and non-green tissue.; Title: similarity to phosphate/phosphoenolpyruvate translocator TABPPT8 - Nicotiana tabacum; See PMID 9090886; uncharacterized protein 69045 4981025 An06g00300 Aspergillus niger uncharacterized protein XP_059603772.1 67620 R 5061 CDS An06g00310 4981020 join(70747..70872,70929..71041,71094..71782,71871..72760) VIII 1 NT_166522.1 Function: P. janthinellum carboxypeptidase D shows broad specificity with optimum pH 4. 5-6. 0, preferential releases a C-terminal arginine or lysine residue and is inhibited by the action of diisopropyl fluorophosphate or thiol-blocking reagents.; Remark: in P. janthinellum carboxypeptidase D the hydrolysis of peptide substrates is apparently dependent on three ionizable group with different pKa values, the substrate preference of the enzyme is consequently pH dependent. .; Similarity: P. janthinellum carboxypeptidase D belongs to peptidase family S10.; Title: similarity to carboxypeptidase D -Penicillium janthinellum; See PMID 8224168; See PMID 3256309; uncharacterized protein 72760 4981020 An06g00310 Aspergillus niger uncharacterized protein XP_059603773.1 70747 D 5061 CDS An06g00320 4981023 complement(join(73378..73406,73466..73691)) VIII 1 NT_166522.1 Remark: the Exon-Intron structure of the predicted A. niger protein is in accordance with the A. niger ESTs Nig056 and an_0358, which also cover the 5' and 3'UTRs.; Title: strong similarity to EST an_0358 -Aspergillus niger; uncharacterized protein 73691 4981023 An06g00320 Aspergillus niger uncharacterized protein XP_001390860.1 73378 R 5061 CDS An06g00330 4981027 join(74151..75105,75143..75575,75637..75901,75953..76339) VIII 1 NT_166522.1 Remark: the facB gene of Aspergillus nidulans is a major regulatory gene involved in acetamide and acetate utilisation.; Similarity: A. nidulans facB belongs to the Zn[2]-Cys[6] fungal-type binuclear cluster proteins.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; See PMID 9197408; See PMID 9524126; See PMID 10483720; uncharacterized protein 76339 4981027 An06g00330 Aspergillus niger uncharacterized protein XP_059603774.1 74151 D 5061 CDS An06g00340 4981005 77302..78858 VIII 1 NT_166522.1 Catalytic activity: carboxylesterases convert a carboxylic ester + H(2)O to an alcohol + a carboxylic anion.; Function: Bacillus estA1 showed clear preference for esters of short-chain fatty acids and maximum activity was found at 45 degrees C and pH 7. 5.; Function: carboxylesterases play an important role in the hydrolytic biotransformation of a vast number of structurally diverse drugs.; Title: similarity to type B carboxylesterase estA1 -Bacillus sp.; See PMID 9597156; See PMID 11178722; uncharacterized protein 78858 4981005 An06g00340 Aspergillus niger uncharacterized protein XP_001390862.3 77302 D 5061 CDS An06g00350 4981034 join(81050..81268,81336..81420,81482..81796,81865..81980,82039..82336,82408..82964) VIII 1 NT_166522.1 Catalytic activity: triacylglycerol lipases convert triacylglycerol + H(2)O convert diacylglycerol + a fatty acid anion.; Function: C. rugosa expresses multiple extracellular lipases of which LIP1 is the most highly and constitutively expressed.; Title: similarity to extracellular triacylglycerol lipase Lip1 - Candida rugosa; extracellular/secretion proteins; See PMID 10473391; uncharacterized protein 82964 4981034 An06g00350 Aspergillus niger uncharacterized protein XP_001390863.1 81050 D 5061 CDS An06g00360 4981035 join(84416..84506,84561..85255,85307..85894) VIII 1 NT_166522.1 Function: mutations in S. cerevisiae dfg5 block filamentous growth.; Remark: the systematic name for S. cerevisiae DFG5 is YMR238w.; Title: strong similarity to filamentous growth protein Dfg5 - Saccharomyces cerevisiae; See PMID 9055077; uncharacterized protein 85894 4981035 An06g00360 Aspergillus niger uncharacterized protein XP_001390864.1 84416 D 5061 CDS An06g00370 4981036 join(86450..86815,86870..87192,87245..87292,87427..87463,87535..87541,87694..87704) VIII 1 NT_166522.1 Catalytic activity: Glutathione transferases convert RX + glutathione to HX + R-S-glutathione.; Function: Rhodococcus sp. isoI is a glutathione S-transferase with activity towards 1,2-epoxy-2-methyl-3-butene.; Function: isoI is involved in isoprene (2-methyl-1,3-butadiene) utilization in Rhodococcus sp. strain AD45.; Remark: the Exon-Intron structure of the predicted A. niger protein is not completely in accordance with the A. niger EST an_1163, which may be due to errors in the genomic sequence or artefacts in the EST.; Title: similarity to glutathione S-transferase isoI - Rhodococcus sp.; See PMID 10715003; uncharacterized protein 87704 4981036 An06g00370 Aspergillus niger uncharacterized protein XP_001390865.3 86450 D 5061 CDS An06g00380 4981037 join(88139..88187,88249..88394,88501..88911,88972..89793) VIII 1 NT_166522.1 Catalytic activity: Hexokinases convert ATP + D-hexose (D-glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors) to ADP + D-hexose 6-phosphate.; Complex: A. niger hxk is a homodimer.; Function: A. niger hxk phosphorylates D-Glucose, the glucose analogue 2-deoxy-D-glucose, D-fructose, D-mannose and D-glucosamine but not D-galactose, L-sorbose, methyl alpha-D-glucoside and the pentoses L-arabinose and D-xylose.; Repression: A. niger hxk is strongly inhibited by physiological concentrations of trehalose 6-phosphate.; Title: strong similarity to hexokinase hxk -Aspergillus niger; See PMID 9851713; uncharacterized protein 89793 4981037 An06g00380 Aspergillus niger uncharacterized protein XP_059603775.1 88139 D 5061 CDS An06g00390 4981038 complement(join(89923..90449,90496..90913,91026..91451)) VIII 1 NT_166522.1 Catalytic activity: Oxoglutarate dehydrogenases convert 2-oxoglutarat e+ lipoamide to S-succinyldihydrolipoamide + CO(2).; Complex: S. cerevisiae KGD1 is a component of the multienzyme 2-oxoglutarate dehydrogenase complex.; Remark: an alternative name for S. cerevisiae KGD1 is OGD1.; Repression: in S. cerevisiae transcription of KGD1 is catabolite repressed.; Similarity: similarity is from the predicted A. niger protein only to half of the central and the C-terminal regions of several oxoglutarate dehydrogenases,which are 600 aa longer.; Title: similarity to oxoglutarate dehydrogenase Kgd1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 2503710; uncharacterized protein 91451 4981038 An06g00390 Aspergillus niger uncharacterized protein XP_059603776.1 89923 R 5061 CDS An06g00400 84591170 complement(join(93453..93803,93929..94165,94300..94429,94514..94631,94687..94828)) VIII 1 NT_166522.1 hypothetical protein 94828 84591170 An06g00400 Aspergillus niger hypothetical protein XP_059603777.1 93453 R 5061 CDS An06g00410 84591171 join(96404..96438,96708..96714,96854..96988) VIII 1 NT_166522.1 Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 96988 84591171 An06g00410 Aspergillus niger uncharacterized protein XP_059603778.1 96404 D 5061 CDS An06g00420 84591172 join(98444..98491,98607..99179,99197..99276,99351..99378) VIII 1 NT_166522.1 Function: S. purpuratus kinesin light chain is a motor molecule required for transport with family specific directionallity to plus or minus ends of microtubuli.; Remark: possible sequencing errors occured at position 45518 and 45818 leading to stop codons, 2 bases have been changed to 'N'.; Similarity: similarity is from the predicted A. niger protein to the N-terminal region of S. purpuratus kinesin light chain, which is 400 aa longer.; Title: similarity to kinesin light chain KLC -Strongylocentrotus purpuratus [putative sequencing error]; cytoskeleton; putative sequencing error; See PMID 8496962; See PMID 10722881; See PMID 10722883; uncharacterized protein 99378 84591172 An06g00420 Aspergillus niger uncharacterized protein XP_059603779.1 98444 D 5061 CDS An06g00430 4981042 complement(join(100051..101053,101102..101277)) VIII 1 NT_166522.1 Catalytic activity: Chalcone synthases convert 3 malonyl-CoA + 4-coumaroyl-CoA to 4 CoA + naringenin-chalcone + 3 CO(2).; Function: G. hybrida GCHS2 is an unusual chalcone synthase, catalysing a non-SS variant of the CHS reaction,with both different substrate specificity (to benzoyl-CoA) and a modified catalytic profile.; Function: rrpA, a Streptomyces griseus homolog of plant Chalcone synthases, was shown to catalyse polyketide synthesis by four successive extensions of malonyl-CoA.; Title: strong similarity to chalcone synthase Gchs2 - Gerbera hybrida; See PMID 7787187; See PMID 8799149; See PMID 10476972; uncharacterized protein 101277 4981042 An06g00430 Aspergillus niger uncharacterized protein XP_001390871.1 100051 R 5061 CDS An06g00440 84591173 complement(join(102872..102896,102970..103129,103186..103311,103392..103541,103634..103676)) VIII 1 NT_166522.1 hypothetical protein 103676 84591173 An06g00440 Aspergillus niger hypothetical protein XP_059603780.1 102872 R 5061 CDS An06g00460 4981045 105858..107402 VIII 1 NT_166522.1 Catalytic activity: cholinesterases convert an acylcholine + H(2)O to choline + a carboxylic acid anion.; Function: B. floridae ChE1 hydrolyzes both acetylthiocholine and butyrylthiocholine.; Localization: the sequence of B. floridae ChE1 shows characteristics of H-type catalytic subunits, which are inserted in the membrane via an ethanolamine-glycan-phosphatidylinositol anchor, and by biochemichal evidence the vast majority of ChE1 is present as ethanolamine-glycan-phosphatidylinositol-anchored form in vivo.; Remark: B. floridae ChE1 contains a novel acyl-binding site.; Title: similarity to cholinesterase 1 ChE1 -Branchiostoma floridae; See PMID 9874207; uncharacterized protein 107402 4981045 An06g00460 Aspergillus niger uncharacterized protein XP_001390873.1 105858 D 5061 CDS An06g00470 4981046 complement(join(107702..108201,108316..108538,108902..109042)) VIII 1 NT_166522.1 Remark: expression of the S. solfataricus AAC38214. 1 ORF was shown by Northern blot.; Title: weak similarity to hypothetical serine-rich protein SPCC553.10 - Schizosaccharomyces pombe; See PMID 9495770; uncharacterized protein 109042 4981046 An06g00470 Aspergillus niger uncharacterized protein XP_059603781.1 107702 R 5061 CDS An06g00480 84591174 complement(join(109489..109794,109844..109902,110053..110171,110675..110877)) VIII 1 NT_166522.1 Function: in addition to reducing the dialdehydic form of aflatoxin B1-8,9-dihydrodiol, human AFAR shows high affinity for the gamma-aminobutyric acid metabolite succinic semialdehyde (SSA).; Similarity: human AFAR is a AKR7-familiy member of the aldo-keto reductase superfamily.; Title: weak similarity to aflatoxin aldehyde reductase AFAR - Homo sapiens; See PMID 9576847; uncharacterized protein 110877 84591174 An06g00480 Aspergillus niger uncharacterized protein XP_059603782.1 109489 R 5061 CDS An06g00490 4981048 join(111909..112103,112180..112216,112275..112342,112408..112787,112849..112910,112978..113324) VIII 1 NT_166522.1 Function: the M. grisea PTH11 gene product is presumably involved in host surface recognition and can activate appressorium differentiation in response to inductive surface cues.; Similarity: similarity is from the predicted A. niger protein to the central region of M. grisea Pth11,which is 300 aa longer.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529; uncharacterized protein 113324 4981048 An06g00490 Aspergillus niger uncharacterized protein XP_001390876.1 111909 D 5061 CDS An06g00500 84591175 complement(join(116024..116778,116853..117564)) VIII 1 NT_166522.1 Remark: blastp with the predicted A. niger protein only retrieves random hits to glutamate, glutamine and lysine rich proteins.; hypothetical protein 117564 84591175 An06g00500 Aspergillus niger hypothetical protein XP_059603783.1 116024 R 5061 CDS An06g00510 4981050 join(119409..119543,119599..120130,120180..120311,120369..120891,120992..121096,121416..121476,121541..121564) VIII 1 NT_166522.1 Catalytic activity: glucan endo-1,3-alpha-glucosidase catalyzes the conversion of Endohydrolysis of 1,3-alpha-D-glucosidic linkages in isolichenin, pseudonigeran and nigeran.; Function: P. purporogenum mutA is a mutanase (glucan endo-1,3-alpha-glucosidase) involved in polysaccharid catabolism.; Title: similarity to alpha-1,3-glucanase mutA -Penicillium purporogenum; See PMID 10636904; uncharacterized protein 121564 4981050 An06g00510 Aspergillus niger uncharacterized protein XP_059603784.1 119409 D 5061 CDS An06g00520 84591176 join(122031..122147,122196..122564) VIII 1 NT_166522.1 hypothetical protein 122564 84591176 An06g00520 Aspergillus niger hypothetical protein XP_059603785.1 122031 D 5061 CDS An06g00530 84591177 join(123132..123475,123538..124075,124134..124604,124652..125143) VIII 1 NT_166522.1 Similarity: the N-terminal region of the predicted A. niger protein shows similarity to several splicosomal and ribosomal proteins.; hypothetical protein 125143 84591177 An06g00530 Aspergillus niger hypothetical protein XP_059603786.1 123132 D 5061 CDS An06g00540 84591178 complement(join(<125262..125727,125954..126052)) VIII 1 NT_166522.1 Induction: A. nidulans stcQ is induced only under ST-producing conditions.; Remark: at position 27607 a possible sequencing error occured and 1 base was removed.; Title: similarity to sterigmatocystin biosynthetic gene stcQ - Aspergillus nidulans [putative frameshift]; putative frameshift; uncharacterized protein 126052 84591178 An06g00540 Aspergillus niger uncharacterized protein XP_059603787.1 125262 R 5061 CDS An06g00550 84591179 complement(join(126312..126383,126456..126695,127196..127265,127949..128493,128691..128778,128899..129015,129059..129169,129259..129308,129370..129393)) VIII 1 NT_166522.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 129393 84591179 An06g00550 Aspergillus niger uncharacterized protein XP_059603788.1 126312 R 5061 CDS An06g00560 4981055 join(129663..129807,129860..129912,129961..130233,130284..130361,130411..130806,130861..131206,131268..131353,131410..131736) VIII 1 NT_166522.1 Induction: S. cerevisiae HXT genes are induced by glucose.; Remark: S. cerevisiae has 20 genes encoding known or likely glucose transporters (HXT 1-20), each of which is known or likely to have a different affinity for glucose.; Repression: S. cerevisiae HXT genes are repressed in the absence of glucose due to a mechanism that requires Rgt1p and Ssn6p.; Title: strong similarity to hexose transporter Hxt13 - Saccharomyces cerevisiae; plasma membrane; See PMID 7862149; See PMID 10477308; uncharacterized protein 131736 4981055 An06g00560 Aspergillus niger uncharacterized protein XP_001390883.1 129663 D 5061 CDS An06g00570 84591180 complement(join(132616..132672,132727..132752,132792..132855,132901..133006,133101..133450)) VIII 1 NT_166522.1 Similarity: the N-terminal of the predicted A. niger protein shows similarity to several kinases and contains a kinase SCOP motif, however overal the similarity is not significant to any protein.; hypothetical protein 133450 84591180 An06g00570 Aspergillus niger hypothetical protein XP_059603789.1 132616 R 5061 CDS An06g00580 4981057 complement(join(133684..135442,135505..135560)) VIII 1 NT_166522.1 Title: strong similarity to hypothetical protein EAA61328.1 - Aspergillus nidulans; uncharacterized protein 135560 4981057 An06g00580 Aspergillus niger uncharacterized protein XP_001390885.1 133684 R 5061 CDS An06g00590 4981058 complement(join(136610..136924,136980..137135)) VIII 1 NT_166522.1 Similarity: the predicted A. niger protein shows strong similarity to to EST an_2107 from Aspergillus niger.; Title: strong similarity to hypothetical protein yrkC - Bacillus subtilis; uncharacterized protein 137135 4981058 An06g00590 Aspergillus niger uncharacterized protein XP_001390886.3 136610 R 5061 CDS An06g00600 4981059 join(140151..140262,140329..140663,140716..141255) VIII 1 NT_166522.1 Function: A. parasiticus adhA catalyses the conversion of 5'-hydroxyaverantin (HAVN) to 5'-ketoaverantin, the open-chain form of averufin (AVF) in the synthesis of aflatoxin.; Pathway: adhA of A. parasiticus catalyzes a step in the aflatoxin biosynthesis.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Title: similarity to short-chain alcohol dehydrogenase adhA - Aspergillus parasiticus; See PMID 11055914; uncharacterized protein 141255 4981059 An06g00600 Aspergillus niger uncharacterized protein XP_001390887.3 140151 D 5061 CDS An06g00610 4981060 complement(join(141577..141593,141672..141709,141840..141895,141942..142439,142490..142609)) VIII 1 NT_166522.1 Function: S. cerevisiae cells depleted of CKA1 and CKA1 increase substantially in size prior to growth arrest,and a significant fraction of the arrested cells exhibit a pseudomycelial morphology.; Function: S. cerevisiae cells in which the CKA2 gene alone is disrupted show no detectable phenotype, but haploid cells carrying disruptions in both the CKA1 and CKA2 genes are inviable.; Remark: Casein kinase II of S. cerevisiae contains two distinct catalytic subunits, alpha and alpha', which are encoded by the CKA1 and CKA2 genes, respectively; Title: weak similarity to casein kinase II Cka2 -Saccharomyces cerevisiae; See PMID 2196445; uncharacterized protein 142609 4981060 An06g00610 Aspergillus niger uncharacterized protein XP_059603790.1 141577 R 5061 CDS An06g00620 4981061 join(144983..145189,145249..145506,145565..145813,145882..146188,146258..146838) VIII 1 NT_166522.1 Function: S. cerevisiae Mal11p is a high-affinity,general alpha-glucoside/proton symporter transporting maltose, turanose, isomaltose, alpha-methylglucoside,maltotriose, palatinose, trehalose and melezitose.; Induction: expression of S. cerevisiae Mal11p is maltose inducible and induction is mediated by the Mal-activator.; Remark: an alternative name for S. cerevisiae MAL11 is AGT1.; Title: strong similarity to alpha-glucoside-hydrogen symporter Mal11 - Saccharomyces cerevisiae; plasma membrane; See PMID 8594329; uncharacterized protein 146838 4981061 An06g00620 Aspergillus niger uncharacterized protein XP_001390889.1 144983 D 5061 CDS An06g00630 4981062 complement(join(147318..147419,147475..148479,148526..148798)) VIII 1 NT_166522.1 Function: N. haematococca detoxify the antibioticum pisatin utilizing the cytochrome P450 monooxygenase PADT9.; Similarity: N. haematococca PDAT9 has been assigned to a new cytochrome P450 family, CYP57.; Title: similarity to cytochrome P450 pisatin demethylase PDAT9 - Nectria haematococca; See PMID 9501474; See PMID 9683653; uncharacterized protein 148798 4981062 An06g00630 Aspergillus niger uncharacterized protein XP_001390890.1 147318 R 5061 CDS An06g00640 4981063 join(149686..149765,149820..149948,150011..150054,150116..150259,150314..150822,150873..151008,151201..151254,151311..151682,151746..152206) VIII 1 NT_166522.1 Function: S. cerevisiae PUT3 binds to DNA sequences in the promoters of the proline utilization genes and is required for the basal and induced expression of the enzymes of this pathway.; Similarity: S. cerevisiae PUT3 is 300 aa longer than the predicted A. niger protein.; Title: similarity to transcription activator Put3 -Saccharomyces cerevisiae; nucleus; See PMID 2017167; uncharacterized protein 152206 4981063 An06g00640 Aspergillus niger uncharacterized protein XP_059603791.1 149686 D 5061 CDS An06g00650 84591181 152850..>153297 VIII 1 NT_166522.1 Function: R. norvegicus 5-Oxoprolinase catalyzes a reaction in which the endergonic cleavage of 5-oxo-L-proline to form L-glutamate is coupled to the exergonic hydrolysis of ATP to ADP and inorganic phosphate.; Remark: ORF 3'truncated due to end of contig.; Title: strong similarity to ATP-hydrolyzing 5-oxoprolinase - Rattus norvegicus [truncated ORF]; See PMID 8943290; uncharacterized protein 153297 84591181 An06g00650 Aspergillus niger uncharacterized protein XP_059603792.1 152850 D 5061 CDS An06g00660 4981065 join(<153519..155027,155079..156401) VIII 1 NT_166522.1 Catalytic activity: ATP + 5-oxo-L-proline + 2 H(2)O = ADP + phosphate + L-glutamate.; Function: OPLA catalyzes a reaction in which the endergonic cleavage of 5-oxo-L-proline to form L-glutamate is coupled to the exergonic hydrolysis of ATP to ADP and inorganic phosphate.; Remark: N-terminally truncated due to contig border.; Remark: The rat kidney enzyme OPLA is composed of two strongly interacting, apparently identical subunits (Mr = 142,000).; Remark: possible sequencing error at position 22722,1 bp too little.; Title: strong similarity to ATP-hydrolyzing 5-oxoprolinase - Rattus norvegicus [truncated ORF]; See PMID 8943290; uncharacterized protein 156401 4981065 An06g00660 Aspergillus niger uncharacterized protein XP_001390893.3 153519 D 5061 CDS An06g00670 4981066 complement(join(156720..157889,157940..158065,158118..160118)) VIII 1 NT_166522.1 Title: strong similarity to hypothetical protein encoded by An02g00370 - Aspergillus niger; uncharacterized protein 160118 4981066 An06g00670 Aspergillus niger uncharacterized protein XP_059600790.1 156720 R 5061 CDS An06g00680 4981067 161139..161705 VIII 1 NT_166522.1 Title: similarity to hypothetical protein encoded by An05g01220 - Aspergillus niger; uncharacterized protein 161705 4981067 An06g00680 Aspergillus niger uncharacterized protein XP_001390895.1 161139 D 5061 CDS An06g00690 84591182 complement(162520..163323) VIII 1 NT_166522.1 Similarity: shows strong similarity against C-terminal part of An05g00630.; Title: weak similarity to hypothetical protein B7N4.20 - Neurospora crassa; uncharacterized protein 163323 84591182 An06g00690 Aspergillus niger uncharacterized protein XP_059600791.1 162520 R 5061 CDS An06g00700 84591183 complement(join(163699..164581,164650..165812)) VIII 1 NT_166522.1 Title: similarity to hypothetical protein B24P7.50 -Neurospora crassa; uncharacterized protein 165812 84591183 An06g00700 Aspergillus niger uncharacterized protein XP_059600792.1 163699 R 5061 CDS An06g00705 10098300 join(165842..166057,166112..166573) VIII 1 NT_166522.1 hypothetical protein 166573 10098300 An06g00705 Aspergillus niger hypothetical protein XP_003188696.2 165842 D 5061 CDS An06g00710 4981071 join(166988..168516,168634..168682,168913..169179,169238..170647) VIII 1 NT_166522.1 Title: similarity to beta-lactamase from patent FR2792651-A1 - Pyrococcus abyssi; uncharacterized protein 170647 4981071 An06g00710 Aspergillus niger uncharacterized protein XP_001390899.3 166988 D 5061 CDS An06g00720 4981072 complement(join(170804..170865,171007..171117,171179..171450,171506..171746,171802..171913)) VIII 1 NT_166522.1 Catalytic activity: the chloroperoxidase converts 2 RH and 2 chloride and H(2)O(2) to 2 RCl and 2 H(2)O.; Function: chloroperoxidase CPO of C. fumago catalyzes peroxidative halogenations involved in the biosynthesis of clardariomycin (2,2-dichloro-1,3-cyclo-pentenedione); the enzyme also has potent catalase activity and in the absence of halide ion, acts as a peroxidase similar to plant peroxidases.; Title: similarity to chloroperoxidase CPO -Caldariomyces fumago; uncharacterized protein 171913 4981072 An06g00720 Aspergillus niger uncharacterized protein XP_001390900.3 170804 R 5061 CDS An06g00730 84591184 complement(join(173267..173415,173524..173570,173683..174130,174482..175772,176222..>176254)) VIII 1 NT_166522.1 Remark: N-terminally truncated due to contig border.; Title: similarity to hypothetical protein encoded by An14g07040 - Aspergillus niger [truncated ORF]; uncharacterized protein 176254 84591184 An06g00730 Aspergillus niger uncharacterized protein XP_059600793.1 173267 R 5061 CDS An06g00740 4981074 join(177693..177793,177852..178268,178467..178695,178756..178947) VIII 1 NT_166522.1 hypothetical protein 178947 4981074 An06g00740 Aspergillus niger hypothetical protein XP_059603793.1 177693 D 5061 CDS An06g00750 4981075 complement(join(180117..180814,180876..181038)) VIII 1 NT_166522.1 Function: NADP-dependent mannitol dehydrogenase (MtDH) is the enzyme responsible for mannitol biosynthesis in Agaricus bisporus.; Remark: mannitol, a six-carbon sugar alcohol, is the main storage carbon in Agaricus bisporus.; Title: strong similarity to NADP-dependent mannitol dehydrogenase MtDH - Agaricus bisporus; See PMID 9835550; uncharacterized protein 181038 4981075 An06g00750 Aspergillus niger uncharacterized protein XP_001390903.1 180117 R 5061 CDS An06g00760 4981076 complement(join(182905..183098,183165..183266,183325..183623,183678..183799,183858..184640)) VIII 1 NT_166522.1 Function: the avnA gene encodes a fungal cytochrome P-450 monooxygenase which is involved in the conversion of averantin to averufin in the aflatoxin biosynthetic pathway in A. parasiticus.; Similarity: AvnA has been assigned to a new P-450 gene family named CYP60A1.; Title: strong similarity to cytochrome P450 monooxygenase avnA - Aspergillus parasiticus; See PMID 9097431; uncharacterized protein 184640 4981076 An06g00760 Aspergillus niger uncharacterized protein XP_001390904.3 182905 R 5061 CDS An06g00770 4981077 complement(join(186038..186442,186510..186670,186725..187231,187281..187352,187403..187730,187793..188023)) VIII 1 NT_166522.1 Function: TOXA of Cochliobolus carbonum encodes an HC-toxin efflux pump which contributes to self-protection against HC-toxin and/or the secretion of HC-toxin into the extracellular milieu.; Title: strong similarity to HC-toxin efflux pump TOXA - Cochliobolus carbonum; plasma membrane; See PMID 10656588; uncharacterized protein 188023 4981077 An06g00770 Aspergillus niger uncharacterized protein XP_001390905.1 186038 R 5061 CDS An06g00780 84591185 complement(join(189937..189961,190018..190882,190915..192056,192145..192335,192841..193227)) VIII 1 NT_166522.1 Remark: only partial similarity to the aminopeptidase.; Remark: see also patent database match against human aminopeptidase.; Title: weak similarity to aminopeptidase N - Felis catus; uncharacterized protein 193227 84591185 An06g00780 Aspergillus niger uncharacterized protein XP_059603794.1 189937 R 5061 CDS An06g00790 84591186 join(193358..193360,193449..193520,193970..194086) VIII 1 NT_166522.1 Remark: questionable ORF due to the gene structure.; Title: questionable ORF; uncharacterized protein 194086 84591186 An06g00790 Aspergillus niger uncharacterized protein XP_059603795.1 193358 D 5061 CDS An06g00800 84591187 complement(194271..195101) VIII 1 NT_166522.1 Remark: transposase is located within the insertion sequence ISTfe1 in Thiobacillus ferrooxidans.; Title: weak similarity to transposase - Thiobacillus ferrooxidans; uncharacterized protein 195101 84591187 An06g00800 Aspergillus niger uncharacterized protein XP_059603796.1 194271 R 5061 CDS An06g00810 4981081 join(195938..195972,196013..>198997) VIII 1 NT_166522.1 Function: mutA of P. purporogenum hydrolysis 1,3-alpha-D-glucosidic links.; Remark: P purporogenum mutA is also named alpha1,3-glucanase.; Remark: putative frameshift at position 4879, 2 bp too much.; Title: strong similarity to mutanase mutA -Penicillium purporogenum [putative frameshift]; putative frameshift; See PMID 10636904; uncharacterized protein 198997 4981081 An06g00810 Aspergillus niger uncharacterized protein XP_059603797.1 195938 D 5061 CDS An06g00820 4981082 join(199267..199404,199622..199823,199915..200165,200214..201323) VIII 1 NT_166522.1 Title: similarity to eukaryotic translation initiation factor eIF2B subunit 3 - Homo sapiens; See PMID 10900014; See PMID 9438375; uncharacterized protein 201323 4981082 An06g00820 Aspergillus niger uncharacterized protein XP_059603798.1 199267 D 5061 CDS An06g00830 4981083 join(201730..201893,201941..202017,202089..202593,202644..203709) VIII 1 NT_166522.1 Title: weak similarity to hypothetical transcription regulatory protein SPBC530.08 - Schizosaccharomyces pombe; uncharacterized protein 203709 4981083 An06g00830 Aspergillus niger uncharacterized protein XP_059603799.1 201730 D 5061 CDS An06g00840 4981084 complement(join(203969..204342,204396..204797,204874..205099)) VIII 1 NT_166522.1 Title: similarity to hypothetical protein SPBC2A9.02 - Schizosaccharomyces pombe; uncharacterized protein 205099 4981084 An06g00840 Aspergillus niger uncharacterized protein XP_001390912.1 203969 R 5061 CDS An06g00850 4981085 complement(join(205636..206129,206197..206340,206430..206526)) VIII 1 NT_166522.1 Catalytic activity: glycerol 3-phosphate + H(2)O = glycerol + phosphate.; Remark: alternate names in yeast = RHR2, YIL053W.; Title: strong similarity to (DL)-glycerol-3-phosphatase 1 Gpp1 - Saccharomyces cerevisiae; cytoplasm; See PMID 8662716; See PMID 9038161; uncharacterized protein 206526 4981085 An06g00850 Aspergillus niger uncharacterized protein XP_059603800.1 205636 R 5061 CDS An06g00860 4981086 complement(206976..207947) VIII 1 NT_166522.1 Title: strong similarity to hypothetical protein CAD21381.1 - Neurospora crassa; uncharacterized protein 207947 4981086 An06g00860 Aspergillus niger uncharacterized protein XP_001390914.1 206976 R 5061 CDS An06g00870 84591188 complement(join(208632..208802,208911..209099)) VIII 1 NT_166522.1 hypothetical protein 209099 84591188 An06g00870 Aspergillus niger hypothetical protein XP_059603801.1 208632 R 5061 CDS An06g00880 84591189 complement(join(209326..209544,209921..210084,210438..210494,210599..210688,210784..210877)) VIII 1 NT_166522.1 Remark: questionable ORF due to the gene structure.; Title: questionable ORF; uncharacterized protein 210877 84591189 An06g00880 Aspergillus niger uncharacterized protein XP_059603802.1 209326 R 5061 CDS An06g00890 4981089 join(211801..211945,212120..212135,212240..212897) VIII 1 NT_166522.1 Similarity: the ORF shows similarity to several oxidoreductases with unspecified function.; Title: weak similarity to gibberellin 20-oxidase -Cucurbita maxima; See PMID 9435996; uncharacterized protein 212897 4981089 An06g00890 Aspergillus niger uncharacterized protein XP_059603803.1 211801 D 5061 CDS An06g00900 4981090 complement(join(215123..215475,215544..215647,215703..215853,215905..216187)) VIII 1 NT_166522.1 hypothetical protein 216187 4981090 An06g00900 Aspergillus niger hypothetical protein XP_059603804.1 215123 R 5061 CDS An06g00920 4981091 complement(217788..218531) VIII 1 NT_166522.1 hypothetical protein 218531 4981091 An06g00920 Aspergillus niger hypothetical protein XP_001390919.1 217788 R 5061 CDS An06g00930 4981092 join(219201..219252,219333..219721) VIII 1 NT_166522.1 Title: weak similarity to hypothetical protein CAD21295.1 - Neurospora crassa; uncharacterized protein 219721 4981092 An06g00930 Aspergillus niger uncharacterized protein XP_001390920.1 219201 D 5061 CDS An06g00940 4981093 join(220540..220548,220630..221137,221196..221321,221376..221600,221668..222032) VIII 1 NT_166522.1 Title: weak similarity to hypothetical nucleobinding precursor NUCB1 - Homo sapiens; uncharacterized protein 222032 4981093 An06g00940 Aspergillus niger uncharacterized protein XP_001390921.3 220540 D 5061 CDS An06g00950 4981094 join(223456..223816,223882..224564) VIII 1 NT_166522.1 Title: similarity to hypothetical protein CAD21295.1 - Neurospora crassa; uncharacterized protein 224564 4981094 An06g00950 Aspergillus niger uncharacterized protein XP_001390922.1 223456 D 5061 CDS An06g00960 84591190 complement(join(225506..225534,225621..226629)) VIII 1 NT_166522.1 Title: similarity to hypothetical ankyrin At2g03430 - Arabidopsis thaliana; uncharacterized protein 226629 84591190 An06g00960 Aspergillus niger uncharacterized protein XP_059603805.1 225506 R 5061 CDS An06g00970 4981096 join(229634..229742,229798..230038,230095..230809) VIII 1 NT_166522.1 Similarity: weak similarity at the carboxyterminus to unknown protein of E. nidulans.; Title: weak similarity to hypothetical protein CAD28442.1 - Aspergillus fumigatus; uncharacterized protein 230809 4981096 An06g00970 Aspergillus niger uncharacterized protein XP_001390924.1 229634 D 5061 CDS An06g00990 4981098 231768..233222 VIII 1 NT_166522.1 Function: enzyme of S. cerevisiae catalyzes the reduction of fumarate to succinate.; Remark: contains binding domain for FAD that is usually noncovalently bound.; Title: strong similarity to soluble cytoplasmic fumarate reductase YEL047c - Saccharomyces cerevisiae; cytoplasm; See PMID 8946166; uncharacterized protein 233222 4981098 An06g00990 Aspergillus niger uncharacterized protein XP_001390926.3 231768 D 5061 CDS An06g01000 4981099 join(235653..235733,235794..235980,236044..236216,236268..236591) VIII 1 NT_166522.1 Similarity: most blast hits result from repetitive sequences.; hypothetical protein 236591 4981099 An06g01000 Aspergillus niger hypothetical protein XP_001390927.1 235653 D 5061 CDS An06g01010 84591191 complement(join(238089..238229,238328..238465,238586..238720)) VIII 1 NT_166522.1 hypothetical protein 238720 84591191 An06g01010 Aspergillus niger hypothetical protein XP_059600794.1 238089 R 5061 CDS An06g01020 4981101 complement(join(240295..240992,241052..241205)) VIII 1 NT_166522.1 Remark: The overexpression of the protein of S. cerevisiae confers resistance to the toxicity of molasses.; Title: similarity to hypothetical molasses resistency protein Rtm1 - Saccharomyces cerevisiae; uncharacterized protein 241205 4981101 An06g01020 Aspergillus niger uncharacterized protein XP_001390929.1 240295 R 5061 CDS An06g01030 4981102 join(242344..242411,242942..242963,243154..243205,243409..243481,243747..244092,244150..245091) VIII 1 NT_166522.1 Remark: similarity spans the C-terminal two-thirds of An01g01370.; Title: similarity to hypothetical protein encoded by An01g01370 - Aspergillus niger; uncharacterized protein 245091 4981102 An06g01030 Aspergillus niger uncharacterized protein XP_001390930.3 242344 D 5061 CDS An06g01040 4981103 join(245908..246064,246153..246245,246343..246599) VIII 1 NT_166522.1 Catalytic activity: protein of S. cerevisiae converts ATP + ubiquitin + protein lysine to AMP + pyrophosphate + protein N-ubiquityllysine.; Function: protein of S. cerevisiae 6 the covalent attachment of ubiquitin to other proteins. Ubc7p is involved in stress related ER degradation. Ubc6p and Ubc7p target unfolded or misfolded lumenal ER proteins for retrograde transport across the ER membrane and subsequent degradation by the proteasome.; Title: strong similarity to ubiquitin conjugation enzyme Ubc7 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 8781238; uncharacterized protein 246599 4981103 An06g01040 Aspergillus niger uncharacterized protein XP_001390931.1 245908 D 5061 CDS An06g01050 4981104 complement(join(247238..247334,247404..247478,247553..248262)) VIII 1 NT_166522.1 Similarity: shows like ORF60CG similarity to 7-aminocholesterol resistance protein RTA1 of S. cerevisiae.; Title: strong similarity to hypothetical protein SPAC17G6.02c - Schizosaccharomyces pombe; uncharacterized protein 248262 4981104 An06g01050 Aspergillus niger uncharacterized protein XP_001390932.1 247238 R 5061 CDS An06g01060 4981105 join(249396..249430,249617..250685) VIII 1 NT_166522.1 Similarity: weak similarity to probable membrane protein YLR228c of S. cerevisiae; covers carboxyterminus of the S. cerevisiae protein only.; Title: similarity to gene expression regulator At14 from patent WO200257456-A2 - Unclassified organism; uncharacterized protein 250685 4981105 An06g01060 Aspergillus niger uncharacterized protein XP_059600795.1 249396 D 5061 CDS An06g01070 4981106 complement(250917..252158) VIII 1 NT_166522.1 Title: similarity to hypothetical protein CG4770 -Drosophila melanogaster; uncharacterized protein 252158 4981106 An06g01070 Aspergillus niger uncharacterized protein XP_001390934.1 250917 R 5061 CDS An06g01080 4981107 complement(join(253166..254048,254098..254316,254369..255529,255580..>255656)) VIII 1 NT_166522.1 Function: might be involved in transportation of cations like zinc.; Localization: probable membrane protein.; Remark: truncated ORF due to contig border, no start codon.; Similarity: shows strong similiarity to cation/efflux domain members.; Title: similarity to hypothetical membrane protein YDR205w - Saccharomyces cerevisiae [truncated ORF]; uncharacterized protein 255656 4981107 An06g01080 Aspergillus niger uncharacterized protein XP_059600796.1 253166 R 5061 CDS An06g01090 84591192 join(255886..256092,256165..256190,256247..256282,256470..256494) VIII 1 NT_166522.1 Remark: multiple putative sequencing errors in contig; blastx analysis of 3' downstream region reveals similarity to aa 1-413 of An11g07820 covering coordinates 129-1495 of the contig. Only the N-terminal part has been extracted as ORF.; Similarity: An11g07820 shows strong similarity to multidrug resistance protein MRP of M. musculus.; Title: similarity to hypothetical protein encoded by An11g07820 - Aspergillus niger [putative sequencing error]; uncharacterized protein 256494 84591192 An06g01090 Aspergillus niger uncharacterized protein XP_059599540.1 255886 D 5061 CDS An06g01100 4981109 join(258686..258923,258983..259179,259256..260200) VIII 1 NT_166522.1 Catalytic activity: GDP-Man + dolichol-PP-GlcNAc2 -> dolichol-PP-GlcNAc2-Man + GDP.; Function: the mannosyltransferase Alg1 from S. cerevisiae participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation.; Title: strong similarity to mannosyltransferase Alg1 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 2182636; See PMID 9675821; uncharacterized protein 260200 4981109 An06g01100 Aspergillus niger uncharacterized protein XP_001390937.1 258686 D 5061 CDS An06g01110 4981110 complement(join(260405..260457,260556..261242,261346..261535,261582..262490,262539..262646)) VIII 1 NT_166522.1 Title: weak similarity to hypothetical protein T1G12.10 - Arabidopsis thaliana; uncharacterized protein 262646 4981110 An06g01110 Aspergillus niger uncharacterized protein XP_059600797.1 260405 R 5061 CDS An06g01120 4981111 join(263287..263328,263525..263589,263651..263875,263956..264079) VIII 1 NT_166522.1 Function: N. crassa Mus-8 rescues the DNA repair,mutagenesis, and sporulation defects of S. cerevisiae rad6 mutants.; Function: substrate specific ubiquitination by Ubiquitin-ligase (E3), in conjunction with ubiquitin-conjugating enzyme (E2), specifically targets proteins for proteasomal degradation.; Similarity: N. crassa Mus-8 is an E2-type ubiquitin-conjugating enzyme.; Title: strong similarity to ubiquitin conjugating enzyme mus-8 - Neurospora crassa; See PMID 9990117; See PMID 8753651; uncharacterized protein 264079 4981111 An06g01120 Aspergillus niger uncharacterized protein XP_001390939.1 263287 D 5061 CDS An06g01130 4981112 join(265050..265054,265122..265159,265237..265331,265404..267826,267892..268120) VIII 1 NT_166522.1 Function: kinesins are microtubule associated motors involved in the transport of membrane bound organelles,transport between the endoplasmic reticulum and the Golgi and transport of protein complexes to cellular destinations.; Remark: in the revised IUPAC Enzyme Nomenclature + and - end directed kinesin is designated the EC Number 3. 6. 4. 4 and 3. 6. 4. 5 respectively.; Title: strong similarity to kinesin heavy chain Nkin - Neurospora crassa; cytoskeleton; See PMID 10754574; See PMID 8631782; uncharacterized protein 268120 4981112 An06g01130 Aspergillus niger uncharacterized protein XP_001390940.1 265050 D 5061 CDS An06g01140 4981113 join(269425..270583,270645..270856) VIII 1 NT_166522.1 Function: S. aerocolonigenes ngt was found to introduce a D-glucose moiety into 6-N-methylarcyriaflavin C.; Title: strong similarity to N-glycosyltransferase ngt - Saccarothrix aerocolonigenes; See PMID 10866221; uncharacterized protein 270856 4981113 An06g01140 Aspergillus niger uncharacterized protein XP_001390941.1 269425 D 5061 CDS An06g01160 4981115 complement(join(271695..271897,271979..272219,272278..272591,272712..273001,273057..273307)) VIII 1 NT_166522.1 Catalytic activity: human SRPK2 is a serine specific kinase catalysing the reaction, ATP + a protein <=> ADP + a phosphoprotein.; Function: human SRPK2 mediates the interaction and localization of pre-mRNA splicing factors by phosphorylating the SR family of splicing factors.; Localization: FLAG- and GFP-tagged human SRPK2 was visible in the cytoplasm and the nuclei of HeLa cells.; Title: similarity to serine kinase SRPK2 - Homo sapiens; deleted EC_number 2.7.1.37; See PMID 9472028; uncharacterized protein 273307 4981115 An06g01160 Aspergillus niger uncharacterized protein XP_059600798.1 271695 R 5061 CDS An06g01170 4981116 join(274896..275216,275272..275721,275782..276693) VIII 1 NT_166522.1 Similarity: the predicted A. niger protein shows similarity to several bacterial hypothetical acetyl-CoA synthetases.; Title: similarity to hypothetical long-chain-fatty-acid--CoA ligase SC6F7.21 - Streptomyces coelicolor; uncharacterized protein 276693 4981116 An06g01170 Aspergillus niger uncharacterized protein XP_059600799.1 274896 D 5061 CDS An06g01180 4981117 complement(join(277164..278621,279020..279070)) VIII 1 NT_166522.1 Similarity: shows also similarity to N-terminal half of An08g01460.; Title: similarity to hypothetical cysteine-binding protein fliY - Haloferax volcanii; uncharacterized protein 279070 4981117 An06g01180 Aspergillus niger uncharacterized protein XP_059600800.1 277164 R 5061 CDS An06g01190 4981118 complement(join(281174..281353,281428..281723,281823..281908,282188..282198)) VIII 1 NT_166522.1 Function: S. cerevisiae Frq1 binds to a conserved sequence motif in Pik1, a phosphatidylinositol-4-OH kinase,outside Pik1's catalytic domain and stimulates its activity in vitro.; Function: S. cerevisiae Frq1 is essential for growth of budding yeast.; Function: in S. cerevisiae N-myristoylated Frq1 may also assist in Pik1 localization.; Localization: subcellular fractionation experiments showed that both the N-myristoyl group and Ca(2+)-binding contribute to the ability of Frq1 to associate with membranes.; Remark: the systematic name for S. cerevisiae Frq1 is YDR373w.; Similarity: S. cerevisiae Frq1 belongs to the recoverin/frequenin branch of the EF-hand superfamily.; Title: strong similarity to Ca(2+)-binding protein Frq1 - Saccharomyces cerevisiae; See PMID 10559922; See PMID 11015193; uncharacterized protein 282198 4981118 An06g01190 Aspergillus niger uncharacterized protein XP_001390945.1 281174 R 5061 CDS An06g01200 4981119 complement(join(283165..283232,283285..283711,283771..284108,284159..285263)) VIII 1 NT_166522.1 Title: strong similarity to endosomal protein Emp70 - Saccharomyces cerevisiae; endosome; See PMID 9729438; See PMID 8314797; uncharacterized protein 285263 4981119 An06g01200 Aspergillus niger uncharacterized protein XP_059600801.1 283165 R 5061 CDS An06g01210 4981120 285680..286846 VIII 1 NT_166522.1 Complex: in S. cerevisiae antibodies directed against Lcp5p specifically immunoprecipitated the yeast U3 snoRNA snR17.; Function: in S. cerevisiae mutations in LCP5 caused defects in pre-ribosomal RNA (pre-rRNA) processing impairing early cleavage steps that lead to the production of mature 18S rRNA.; Localization: in S. cerevisiae indirect immunofluorescence indicated a predominant localization of Lcp5p in the nucleolus.; Remark: the systematic name for S. cerevisiae LCP5 is YER127w.; Title: similarity to rRNA processing protein Lcp5 -Saccharomyces cerevisiae; nucleus; See PMID 9814757; uncharacterized protein 286846 4981120 An06g01210 Aspergillus niger uncharacterized protein XP_001390947.1 285680 D 5061 CDS An06g01220 4981121 join(287342..287354,287448..287660,287924..288105) VIII 1 NT_166522.1 hypothetical protein 288105 4981121 An06g01220 Aspergillus niger hypothetical protein XP_059600802.1 287342 D 5061 CDS An06g01260 4981125 join(291780..292222,292322..292709) VIII 1 NT_166522.1 Title: strong similarity to hypothetical protein CAC28835.1 - Neurospora crassa; uncharacterized protein 292709 4981125 An06g01260 Aspergillus niger uncharacterized protein XP_001390949.1 291780 D 5061 CDS An06g01270 4981126 join(293773..294009,294057..295592) VIII 1 NT_166522.1 Catalytic activity: N. crassa uve1 cleaves both cyclobutane pyrimidine dimers and (6-4)photoproducts at the sites immediately 5' to the damaged dipyrimidines in a magnesium-dependent, ATP-independent reaction.; Function: N. crassa uve1 specifically repairs DNA damaged by ultraviolet light.; Remark: N. crassa uve1 confers UV-resistance on various DNA repair-deficient mutants of S. cerevisiae and a human xeroderma pigmentosum cell line.; Title: strong similarity to UV-endonuclease uve1 -Neurospora crassa; nucleus; See PMID 7774597; uncharacterized protein 295592 4981126 An06g01270 Aspergillus niger uncharacterized protein XP_059600803.1 293773 D 5061 CDS An06g01290 4981128 join(301800..301988,302038..302074,302128..302195,302349..302632,302700..303120) VIII 1 NT_166522.1 Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea; uncharacterized protein 303120 4981128 An06g01290 Aspergillus niger uncharacterized protein XP_059600804.1 301800 D 5061 CDS An06g01300 4981129 complement(join(303770..317503,317567..318001)) VIII 1 NT_166522.1 Function: AM-toxin synthetase (AMT) is a primary determinant of virulence and specificity in the A. alternata apple pathotype/apple interaction.; Remark: Afternaria afternata apple pathotype causes Alternaria blotch of susceptible apple cultivars through the production of a cyclic peptide host-specific toxin,AM-toxin.; Title: strong similarity to cyclic peptide AM-toxin synthase AMT - Alternaria alternata; See PMID 10875335; uncharacterized protein 318001 4981129 An06g01300 Aspergillus niger uncharacterized protein XP_001390952.1 303770 R 5061 CDS An06g01310 84591193 join(319837..319842,319939..320028,320079..320228) VIII 1 NT_166522.1 hypothetical protein 320228 84591193 An06g01310 Aspergillus niger hypothetical protein XP_059600805.1 319837 D 5061 CDS An06g01320 4981131 join(320761..321166,321224..321521,321570..321949,322006..322335,322449..322789) VIII 1 NT_166522.1 Catalytic activity: ATP dependent conversion of ferulic acid to feruloyl-Coenzyme A.; Pathway: Fcs catalyzes a step in the bioconversion of ferulic acid to vanillin.; Title: strong similarity to feruloyl-CoA synthase fcs - Amycolatopsis sp.; See PMID 11152072; uncharacterized protein 322789 4981131 An06g01320 Aspergillus niger uncharacterized protein XP_001390954.1 320761 D 5061 CDS An06g01330 84591194 complement(join(323875..324025,324110..324129)) VIII 1 NT_166522.1 hypothetical protein 324129 84591194 An06g01330 Aspergillus niger hypothetical protein XP_059600806.1 323875 R 5061 CDS An06g01340 84591195 complement(join(325074..325401,325518..325546,325787..>326422)) VIII 1 NT_166522.1 Remark: N-terminally truncated due to contig border.; Title: weak similarity to hypothetical possible phosphatase L8329.04 - Leishmania major [truncated ORF]; uncharacterized protein 326422 84591195 An06g01340 Aspergillus niger uncharacterized protein XP_059600807.1 325074 R 5061 CDS An06g01350 4981134 complement(join(<326525..327486,327563..327767)) VIII 1 NT_166522.1 Remark: ORF 3'truncated due to end of contig.; Remark: blastp with the predicted A. niger protein only retrieves random hits to proline rich proteins.; hypothetical protein [truncated ORF] 327767 4981134 An06g01350 Aspergillus niger hypothetical protein [truncated ORF] XP_059600808.1 326525 R 5061 CDS An06g01360 4981135 complement(join(328526..329107,329173..329670,329761..329784)) VIII 1 NT_166522.1 Function: S. cerevisiae BSD2 down-regulates heavy metal uptake by the Nramp metal transporters Smf1p and Smf2p at the level of protein stability.; Function: in bsd2Delta mutants, Smf1p and Smf2p fail to enter the vacuole where they are normally degraded by vacuolar proteases in a PEP4-dependent manner.; Title: similarity to metal homeostasis protein Bsd2 - Saccharomyces cerevisiae; See PMID 9115231; See PMID 9988727; See PMID 11027260; uncharacterized protein 329784 4981135 An06g01360 Aspergillus niger uncharacterized protein XP_001390958.1 328526 R 5061 CDS An06g01370 4981136 complement(join(331021..331334,331392..332571,332637..332699)) VIII 1 NT_166522.1 Catalytic activity: 3-oxoacid CoA-transferases convert Succinyl-CoA + a 3-oxo acid to succinate + a 3-oxo-acyl-CoA.; Complex: human SCOT forms a homodimer.; Function: human SCOT mediates the rate-determining step of ketolysis, the esterification of acetoacetate to CoA for use in energy production.; Title: strong similarity to Succinyl CoA: 3-oxoacid CoA transferase SCOT - Homo sapiens; localisation:mitochondrion; See PMID 8751852; uncharacterized protein 332699 4981136 An06g01370 Aspergillus niger uncharacterized protein XP_001390959.1 331021 R 5061 CDS An06g01380 4981137 complement(join(333684..334204,334262..334433,334489..334909,334965..335352,335524..335643,335699..336236,336291..336379,336431..336825,336876..336921,336976..337183,337235..337983,338085..338106)) VIII 1 NT_166522.1 Function: ubiquitin-specific proteases like S. cerevisiae UPB2 cleave ubiquitin fusions to itself or other proteins after the last (Gly76) residue of ubiquitin.; Title: strong similarity to ubiquitin specific protease Ubp2 - Saccharomyces cerevisiae; cytoplasm; See PMID 1429680; uncharacterized protein 338106 4981137 An06g01380 Aspergillus niger uncharacterized protein XP_059600809.1 333684 R 5061 CDS An06g01390 4981138 join(338647..338827,338901..339020,339081..339275,339349..339440) VIII 1 NT_166522.1 Title: strong similarity to 21.3 kD subunit of NADH:ubiquinone reductase - Neurospora crassa; localisation:mitochondrion; See PMID 1825789; See PMID 10940377; uncharacterized protein 339440 4981138 An06g01390 Aspergillus niger uncharacterized protein XP_001390961.1 338647 D 5061 CDS An06g01400 4981139 join(<343225..343660,343715..344202,344255..344592,344655..345804) VIII 1 NT_166522.1 Function: Ask10p of S. cerevisiae is a transcription factor involved in a Skn7p-mediated two-component regulatory system.; Remark: the ORF is N-terminally truncated due to end of contig. .; Similarity: YIL105c of S. cerevisiae is similar to transcriptional activator Ask10p of S. cerevisiae.; Similarity: the N-terminal portion shows similarity to transcription regulator protein Ask10p of S. cerevisiae.; Title: strong similarity to hypothetical protein YIL105c - Saccharomyces cerevisiae [truncated ORF]; See PMID 8904339; uncharacterized protein 345804 4981139 An06g01400 Aspergillus niger uncharacterized protein XP_001390962.3 343225 D 5061 CDS An06g01410 84591196 complement(join(346743..346835,346932..347187,347399..347520)) VIII 1 NT_166522.1 hypothetical protein 347520 84591196 An06g01410 Aspergillus niger hypothetical protein XP_059605282.1 346743 R 5061 CDS An06g01420 4981141 complement(347713..349287) VIII 1 NT_166522.1 Function: TOL in N. crassa mediates growth inhibition and cell death as a result of mating-type-associated heterokaryon incompatibility during vegetative growth.; Similarity: the homology is restricted to the central portion of TOL from N. crassa.; Title: similarity to mating-type-associated vegetative incompatibility factor TOL - Neurospora crassa; See PMID 9927450; uncharacterized protein 349287 4981141 An06g01420 Aspergillus niger uncharacterized protein XP_059605283.1 347713 R 5061 CDS An06g01430 4981142 join(351070..351076,351450..352199,352287..352993) VIII 1 NT_166522.1 Title: strong similarity to hypothetical protein encoded by An14g06130 - Aspergillus niger; uncharacterized protein 352993 4981142 An06g01430 Aspergillus niger uncharacterized protein XP_001390965.3 351070 D 5061 CDS An06g01440 4981143 complement(join(355719..355803,355899..356085,356181..356232,356312..356449,356513..356606,356794..356860,356960..357347)) VIII 1 NT_166522.1 Function: TOM34 (HRB1) of S. cerevisiae is a hnRNP-like protein of unknown function possibly involved in RNA processing and export.; Localization: TOM34 (HRB1) of S. cerevisiae is capable of shuttling between the nucleus and the cytoplasm.; Remark: TOM34 of S. cerevisiae is also named HRB1.; Remark: a splice site was detected upstream of the START codon.; Similarity: contains three RNA-binding motives.; Similarity: shows much better homology to S. pombe hrb1 homolog, but the latter is so far not experimentally confirmed.; Title: similarity to heterogeneous nuclear ribonucleoprotein (hnRNP) Tom34 - Saccharomyces cerevisiae; See PMID 9499403; uncharacterized protein 357347 4981143 An06g01440 Aspergillus niger uncharacterized protein XP_059605284.1 355719 R 5061 CDS An06g01450 84591197 join(357376..357558,357597..357674,357720..357835,357968..358234,358405..358454,358553..358957,359008..359082,359159..359278,359385..359470,359673..359741) VIII 1 NT_166522.1 Title: weak similarity to U1 snRNP 70K protein - Mus musculus; uncharacterized protein 359741 84591197 An06g01450 Aspergillus niger uncharacterized protein XP_059605285.1 357376 D 5061 CDS An06g01460 4981145 join(361029..361076,361164..361496) VIII 1 NT_166522.1 Title: similarity to hypothetical protein SPAC19G12.11 - Schizosaccharomyces pombe; uncharacterized protein 361496 4981145 An06g01460 Aspergillus niger uncharacterized protein XP_001390968.3 361029 D 5061 CDS An06g01470 4981146 complement(361685..363064) VIII 1 NT_166522.1 Similarity: the ORF is much shorter than igA of N. meningitidis (459 compared to 1773 amino acids) and the homology between the two proteins is restricted to a stretch of about 200 amino acids.; Title: weak similarity to IgA-specific metalloendopeptidase igA - Neisseria meningitidis; uncharacterized protein 363064 4981146 An06g01470 Aspergillus niger uncharacterized protein XP_001390969.1 361685 R 5061 CDS An06g01480 4981147 join(363375..363909,363970..364453,364569..364770,364899..364967,365067..365134,365179..365266,365301..365414) VIII 1 NT_166522.1 Remark: the homology between the ORF and the hypothetical yeast protein is restricted to about 400 N-terminal amino acids.; Title: similarity to hypothetical protein YDL156w -Saccharomyces cerevisiae; uncharacterized protein 365414 4981147 An06g01480 Aspergillus niger uncharacterized protein XP_059605286.1 363375 D 5061 CDS An06g01490 4981148 complement(join(365849..366807,366860..367571,367633..368336,368464..369337)) VIII 1 NT_166522.1 Function: CLA2 of S. cerevisiae stimulates the GTPase activity of BUD1/RSR1 and thus participates in the regulation of the BUD site selection (axial budding).; Phenotype: chromosomal deletion of CLA2 of S. cerevisiae causes a random budding pattern but no obvious growth defect. Overexpression of BUD2 also causes a random budding pattern.; Remark: CLA2 of S. cerevisiae is also called BUD2,ERC25, or YKL092C.; Remark: CLA2 of S. cerevisiae is similar to other ras GTPase-activating proteins (GAPs).; Similarity: the ORF shows local strong similarity to CLA2 of S. cerevisiae: the two proteins have about the same length, however, only about 400 central amino acids are included in the alignment. The aligned stretch includes the C2-domain and RAS-GAP of CLA2.; Title: strong similarity to inhibitory regulator protein Cla2 - Saccharomyces cerevisiae; See PMID 8262070; See PMID 8371782; uncharacterized protein 369337 4981148 An06g01490 Aspergillus niger uncharacterized protein XP_059605287.1 365849 R 5061 CDS An06g01500 4981149 join(374161..374891,374959..377053) VIII 1 NT_166522.1 Function: Apg9p/Cvt7p of S. cerevisiae is an integral membrane protein required for transport vesicle formation in the cvt and autophagy pathways.; Title: similarity to integral membrane protein required for Cvt and autophagy transport Apg9 -Saccharomyces cerevisiae; See PMID 10662773; uncharacterized protein 377053 4981149 An06g01500 Aspergillus niger uncharacterized protein XP_059605288.1 374161 D 5061 CDS An06g01510 4981150 join(379833..380839,380907..382472,382533..382569) VIII 1 NT_166522.1 Function: in vivo expression of the cDNA of S. frugiperda using a recombinant baculovirus produced a protein that released [3H]mannose from [3H]Man9GlcNAc.; Function: these results indicate that Sf9 cells encode and express an alpha 1,2-mannosidase with properties similar to those of other eukaryotic processing alpha 1,2-mannosidases.; Function: this activity required calcium, but not magnesium, and was inhibited by 1-deoxymannojirimycin.; Title: strong similarity to class I alpha-mannosidase AAB62720.1 - Spodoptera frugiperda; See PMID 9147053; uncharacterized protein 382569 4981150 An06g01510 Aspergillus niger uncharacterized protein XP_001390973.1 379833 D 5061 CDS An06g01520 4981151 join(383415..383577,383629..383747,383816..384050,384116..384216,384270..384426,384474..385876) VIII 1 NT_166522.1 Similarity: similarity restricted to aminoterminal part of the putative protein.; Title: similarity to hypothetical protein SPBC24C6.10c - Schizosaccharomyces pombe; uncharacterized protein 385876 4981151 An06g01520 Aspergillus niger uncharacterized protein XP_059605289.1 383415 D 5061 CDS An06g01530 4981152 complement(join(387165..388043,388106..388251,388306..388372)) VIII 1 NT_166522.1 Function: S. cerevisiae protein is responsible for successive hydrolysis of beta-D-glucose units from the non-reducing ends of 1,3-beta-D-glucans, releasing alpha-glucose.; Function: it can link beta-1,3-glucan chains with beta-1,6-linkage.; Function: it may play a role in cell expansion during growth, in mating, and in spore release.; Similarity: stronger similarity to several putative cell wall proteins of S. cerevisiae.; Title: similarity to glucan 1,3-beta-glucosidase Bgl2 - Saccharomyces cerevisiae; cell wall; See PMID 9090054; See PMID 9748433; uncharacterized protein 388372 4981152 An06g01530 Aspergillus niger uncharacterized protein XP_001390975.1 387165 R 5061 CDS An06g01540 4981153 complement(join(389293..389475,389534..390025,390083..390593,390660..390988)) VIII 1 NT_166522.1 Function: S. cerevisiae enzyme converts palmitoyl-CoA + L-serine to CoA + 3-dehydro-D-sphinganine + CO2.; Pathway: first step in the biosynthesis of the long-chain base component of sphingolipids.; Title: strong similarity to serine C-palmitoyltransferase chain Lcb1 - Saccharomyces cerevisiae; uncharacterized protein 390988 4981153 An06g01540 Aspergillus niger uncharacterized protein XP_001390976.1 389293 R 5061 CDS An06g01550 4981154 complement(join(391763..392048,392106..397376,397452..397588)) VIII 1 NT_166522.1 Function: 1,3-beta-D-glucan is a fungal cell wall polymer synthesized by the multi-subunit enzyme 1,3-beta-D-glucan synthase.; Function: glycosyl transferase is a membrane protein for fungal cell wall synthesis.; Title: strong similarity to glucan synthase FKS -Paracoccidioides brasiliensis; plasma membrane; uncharacterized protein 397588 4981154 An06g01550 Aspergillus niger uncharacterized protein XP_001390977.1 391763 R 5061 CDS An06g01560 84591198 complement(join(399520..399707,399811..399829)) VIII 1 NT_166522.1 hypothetical protein 399829 84591198 An06g01560 Aspergillus niger hypothetical protein XP_059605290.1 399520 R 5061 CDS An06g01580 4981157 join(405307..406376,406433..407507) VIII 1 NT_166522.1 Remark: Only the the c-terminal half of the ORF encoded protein shows a strong similarity to the S. pombe hypothetical protein SPBC19G7. 04.; Title: similarity to hypothetical protein SPBC19G7.04 - Schizosaccharomyces pombe; uncharacterized protein 407507 4981157 An06g01580 Aspergillus niger uncharacterized protein XP_001390979.1 405307 D 5061 CDS An06g01590 4981158 complement(join(407826..408396,408465..408559)) VIII 1 NT_166522.1 Remark: S. cerevisiae Mog1p is involved in nuclear-protein import.; Remark: the S. cerevisiae Mog1p, directly interacts with GTP-Gsp1p, the S. cerevisiae ran homologue.; Title: similarity to protein Mog1 - Saccharomyces cerevisiae; See PMID 9860978; uncharacterized protein 408559 4981158 An06g01590 Aspergillus niger uncharacterized protein XP_001390980.1 407826 R 5061 CDS An06g01600 4981159 complement(join(409287..409907,409955..410893)) VIII 1 NT_166522.1 Title: similarity to hypothetical protein T22D1.2 -Caenorhabditis elegans; uncharacterized protein 410893 4981159 An06g01600 Aspergillus niger uncharacterized protein XP_001390981.1 409287 R 5061 CDS An06g01610 4981160 join(411846..411879,411959..412151,412214..412256) VIII 1 NT_166522.1 Similarity: the ORF encoded protein shows the strongest similarity to the Awh11 heat shock protein from Emericella nidulans, functional studies about it are not published yet.; Title: strong similarity to heat shock protein hsp9p - Schizosaccharomyces pombe; See PMID 8679693; uncharacterized protein 412256 4981160 An06g01610 Aspergillus niger uncharacterized protein XP_001390982.1 411846 D 5061 CDS An06g01620 4981161 complement(join(412487..413196,413265..413283)) VIII 1 NT_166522.1 Remark: the ApsB protein from Emericella nidulans seams to play a role in the regulation nuclear migration.; Remark: the ORF encoded protein (241aa) shows similarity to ApsB (1051aa) from Emericella nidulans with an E. val of 2e-05.; Title: similarity to protein apsB - Aspergillus nidulans; See PMID 10094631; uncharacterized protein 413283 4981161 An06g01620 Aspergillus niger uncharacterized protein XP_059605291.1 412487 R 5061 CDS An06g01630 4981162 join(413624..413926,413981..414682,414764..415909) VIII 1 NT_166522.1 Title: strong similarity to hypothetical protein KIAA1134 - Homo sapiens; uncharacterized protein 415909 4981162 An06g01630 Aspergillus niger uncharacterized protein XP_059605292.1 413624 D 5061 CDS An06g01640 4981163 complement(join(416105..416934,416994..417119,417175..417218,417285..417349)) VIII 1 NT_166522.1 Remark: S. cerevisiae NGG1 = ADA3.; Remark: interaction between (S. cer) Nif1p and (S. cer.) Ngg1p/Ada3p was found in a large-scale yeast two-hybrid screen.; Title: strong similarity to Ngg1p-interacting factor Nif3 - Saccharomyces cerevisiae; See PMID 10688190; uncharacterized protein 417349 4981163 An06g01640 Aspergillus niger uncharacterized protein XP_001390985.3 416105 R 5061 CDS An06g01650 4981164 join(417950..418046,418149..418324) VIII 1 NT_166522.1 Title: strong similarity to hypothetical protein encoded by AAM68636.1 - Drosophila melanogaster; uncharacterized protein 418324 4981164 An06g01650 Aspergillus niger uncharacterized protein XP_001390986.3 417950 D 5061 CDS An06g01660 4981165 complement(join(418584..418612,418666..418831,418898..418943,419009..419108,419227..419434)) VIII 1 NT_166522.1 Remark: the Mouse peroxiredoxin V is a thioredoxin peroxidase that inhibits p53-induced apoptosis.; Title: strong similarity to thioredoxin peroxidase PMP20 - Mus musculus; See PMID 1067930; uncharacterized protein 419434 4981165 An06g01660 Aspergillus niger uncharacterized protein XP_001390987.1 418584 R 5061 CDS An06g01670 84591199 join(420581..420594,420652..420895) VIII 1 NT_166522.1 hypothetical protein 420895 84591199 An06g01670 Aspergillus niger hypothetical protein XP_059605293.1 420581 D 5061 CDS An06g01690 4981168 join(422636..422692,422787..422803,422994..423066,423150..423293,423355..424257,424311..424500,424576..425096) VIII 1 NT_166522.1 Function: the S. cerevsiae Skn7 regulator may be involved in response to oxidative stress.; Remark: the ORF encoded protein belongs to the helix-turn-helix transcription factor family.; Title: similarity to transcription regulator Skn7 -Saccharomyces cerevisiae; See PMID 8226633; See PMID 8598053; uncharacterized protein 425096 4981168 An06g01690 Aspergillus niger uncharacterized protein XP_001390990.1 422636 D 5061 CDS An06g01700 84591200 join(425360..425521,425619..425664,425746..425986,426235..426520) VIII 1 NT_166522.1 hypothetical protein 426520 84591200 An06g01700 Aspergillus niger hypothetical protein XP_059605294.1 425360 D 5061 CDS An06g01710 4981170 join(426611..426688,426764..426820,426903..427027,427104..428278,428341..429017) VIII 1 NT_166522.1 Complex: the S. cerevisiae GCD6 gene product is part of a complex of five different subunits alpha (GCN3), beta (GCD7), gamma (GCD1), delta (GCD2) and epsilon (GCD6).; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to translation initiation factor eIF2b epsilon Gcd6 - Saccharomyces cerevisiae; See PMID 8441423; See PMID 9032257; See PMID 926828; See PMID 9472020; uncharacterized protein 429017 4981170 An06g01710 Aspergillus niger uncharacterized protein XP_001390992.1 426611 D 5061 CDS An06g01720 4981171 join(430502..430571,430644..431172,431229..432115,432171..432199) VIII 1 NT_166522.1 Similarity: the ORF encoded shows strong similarity to the D. melanogaster ariadne protein and its homologues.; Title: strong similarity to Ariadne protein ari -Drosophila melanogaster; uncharacterized protein 432199 4981171 An06g01720 Aspergillus niger uncharacterized protein XP_001390993.3 430502 D 5061 CDS An06g01730 4981172 join(434681..434718,434890..434992,435065..435100,435217..435349,435421..435513,435576..435632,435698..436145,436235..436286) VIII 1 NT_166522.1 Function: MRS3 (S. cer.) is essential for the splicing of group II introns and is also involved in processes of mitochondrial biogenesis other than RNA splicing.; Function: MRS3 (S. cer.) may act as a carrier,exerting its suppressor activity via modulation of solute concentrations in the mitochondria.; Function: the MRS3 gene product of S. cerevisiae probably is involved in splicing of aI1 intron for COB gene.; Similarity: the ORF encoded protein is a member of the mitochondrial carrier family.; Title: strong similarity to mtRNA splice defect-suppressing mitochondrial carrier Mrs3 -Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 2448588; See PMID 1703236; uncharacterized protein 436286 4981172 An06g01730 Aspergillus niger uncharacterized protein XP_059605295.1 434681 D 5061 CDS An06g01740 4981173 join(437732..437818,437950..439993,440052..440272) VIII 1 NT_166522.1 Similarity: the ORF encoded protein shows also strong similarity to the to regulatory subunits of 26s proteasome from S. cerevisiae Yta6p and its S. pombe homologue with the gene ID: SPDB:SPBC947. 01.; Title: strong similarity to SIN1-associated protein Sap1 - Saccharomyces cerevisiae; See PMID 8654588; See PMID 9695811; uncharacterized protein 440272 4981173 An06g01740 Aspergillus niger uncharacterized protein XP_001390995.1 437732 D 5061 CDS An06g01750 4981174 complement(join(441874..443237,443311..443531,443603..443672,443820..443892)) VIII 1 NT_166522.1 Complex: the human epsin 2a binds to clathrin heavy chain, AP-2, Eps15, and intersectin.; Title: strong similarity to clathrin binding protein epsin-2a - Homo sapiens; See PMID 10567358; uncharacterized protein 443892 4981174 An06g01750 Aspergillus niger uncharacterized protein XP_001390996.1 441874 R 5061 CDS An06g01760 4981175 complement(join(445648..446969,447047..447120,447196..447344,447465..447476)) VIII 1 NT_166522.1 Catalytic activity: chorismate + L-glutamine <=> anthranilate + pyruvate+L-glutamate.; Complex: the S. cerevisiae homolog anthranilate synthase:indole-3-glycerol phosphate synthase is a multifunctional hetero-oligomeric enzyme encoded by genes TRP2 and TRP3.; Function: the S. cerevisiae homolog TRP2 encodes the anthranilate synthase subunit I.; Pathway: tryptophan biosynthesis.; Title: strong similarity to anthranilate synthase component I Trp2 - Saccharomyces cerevisiae; See PMID 6323449; See PMID 8432699; uncharacterized protein 447476 4981175 An06g01760 Aspergillus niger uncharacterized protein XP_001390997.1 445648 R 5061 CDS An06g01770 4981176 join(448438..448982,449052..449376) VIII 1 NT_166522.1 Similarity: the ORF encoded protein shows a weak similarity to paramyosin from C. elegans E. val. : 0. 23.; Title: weak similarity to paramyosin unc-15 -Caenorhabditis elegans; See PMID 2754728; See PMID 2754733; See PMID 8408214; uncharacterized protein 449376 4981176 An06g01770 Aspergillus niger uncharacterized protein XP_001390998.1 448438 D 5061 CDS An06g01780 4981177 complement(join(449978..451723,451819..451967,452038..452054,452162..452211)) VIII 1 NT_166522.1 Complex: the human TBL1 protein is part of a core SMRT corepressor complex containing the histondeacetylase HDAC3.; Title: strong similarity to (beta)-transducin like protein TBL1 - Homo sapiens; See PMID 10330347; See PMID 10809664; See PMID 10944117; uncharacterized protein 452211 4981177 An06g01780 Aspergillus niger uncharacterized protein XP_059605296.1 449978 R 5061 CDS An06g01790 84591201 join(452945..453060,453177..453348) VIII 1 NT_166522.1 hypothetical protein 453348 84591201 An06g01790 Aspergillus niger hypothetical protein XP_059605297.1 452945 D 5061 CDS An06g01800 84591202 complement(join(454007..454010,454267..454457)) VIII 1 NT_166522.1 Title: questionable ORF; uncharacterized protein 454457 84591202 An06g01800 Aspergillus niger uncharacterized protein XP_059605298.1 454007 R 5061 CDS An06g01810 4981180 join(455079..455470,455540..456257) VIII 1 NT_166522.1 Remark: the human gene for the PL16 protein was found as a novel human cDNA that is homozygously deleted in small cell lung cancerand located to 3p21. 3.; Title: strong similarity to protein PL6 - Homo sapiens; uncharacterized protein 456257 4981180 An06g01810 Aspergillus niger uncharacterized protein XP_001391002.1 455079 D 5061 CDS An06g01820 4981181 complement(join(456808..457386,457613..457651)) VIII 1 NT_166522.1 Remark: the ORF encoded protein shows also weak similarity to the 'real' ribosomal protein MRP49 from the S. cerevisiae mitochondria with an E. -val. of 1e-04.; Title: similarity to hypothetical ribosomal protein B13I18.70 - Neurospora crassa; mitochondrial 54S ribosomal protein mL61 457651 4981181 An06g01820 Aspergillus niger mitochondrial 54S ribosomal protein mL61 XP_001391003.1 456808 R 5061 CDS An06g01830 4981182 join(458401..458475,458557..461060,461264..461462,461520..462122) VIII 1 NT_166522.1 Catalytic activity: ATP + L-leucine + tRNA(Leu) <=> AMP + diphosphate + L-leucyl-tRNA(Leu).; Title: strong similarity to cytosolic leucine--tRNA ligase - Neurospora crassa; cytoplasm; See PMID 2532300; See PMID 2842224; uncharacterized protein 462122 4981182 An06g01830 Aspergillus niger uncharacterized protein XP_001391004.1 458401 D 5061 CDS An06g01840 4981183 complement(join(462484..462514,462610..462819,462917..463084,463144..463223,463288..463493,463549..463951,464119..464244)) VIII 1 NT_166522.1 Catalytic activity: 1-aminocyclopropane-1-carboxylate + H(2)O <=> 2-oxobutanoate + NH(3).; Remark: in Penicillium citrinum two enzyms could be found which are involved in the biosythesis of ethylene,known as plant hormone of higher plants: ACC synthase [EC 4. 4. 1. 14] and ACC deaminase [EC 4. 1. 99. 4]. ACC=1-Aminocyclopropane-1-carboxylic acid= Ethylen precursor.; Title: strong similarity to 1-aminocyclopropane-1-carboxylate deaminase,acs -Penicillium citrinum; See PMID 10227140; See PMID 10737185; uncharacterized protein 464244 4981183 An06g01840 Aspergillus niger uncharacterized protein XP_059605299.1 462484 R 5061 CDS An06g01850 4981184 complement(join(464715..466198,466302..466761)) VIII 1 NT_166522.1 Title: strong similarity to hypothetical protein B13I18.80 - Neurospora crassa; uncharacterized protein 466761 4981184 An06g01850 Aspergillus niger uncharacterized protein XP_059605300.1 464715 R 5061 CDS An06g01860 4981185 complement(467147..468073) VIII 1 NT_166522.1 Title: strong similarity to hypothetical protein SPAC31G5.18c - Schizosaccharomyces pombe; uncharacterized protein 468073 4981185 An06g01860 Aspergillus niger uncharacterized protein XP_001391007.1 467147 R 5061 CDS An06g01870 4981186 join(468490..468491,468557..468606,468718..468878,468939..469190) VIII 1 NT_166522.1 Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S10 - Saccharomyces cerevisiae; cytoplasm; See PMID 9396790; See PMID 9421530; 40S ribosomal protein eS10 469190 4981186 An06g01870 Aspergillus niger 40S ribosomal protein eS10 XP_001391008.1 468490 D 5061 CDS An06g01880 4981187 complement(join(469492..470434,470487..470801,470931..471178)) VIII 1 NT_166522.1 Function: HyuC from Pseudomonas sp. (strain NS671) converts N-carbamyl-L-amino acids to L-amino acids.; Pathway: HyuC from Pseudomonas sp. (strain NS671) is involved in conversion of 5-substituted hydantoins to corresponding L-amino acids.; Similarity: HyuC from Pseudomonas sp. (strain NS671) belongs to peptidase family M40, also known as the Ama/HipO/HyuC family of hydrolases.; Title: strong similarity to N-carbamyl-L-amino acid amidohydrolase HyuC - Pseudomonas sp.; See PMID 1732229; uncharacterized protein 471178 4981187 An06g01880 Aspergillus niger uncharacterized protein XP_001391009.3 469492 R 5061 CDS An06g01890 4981188 join(472352..472391,472502..472584,472844..472912,473093..473185,473248..473262,473366..473473) VIII 1 NT_166522.1 Remark: Hnt1 from S. cerevisiae interacts with the cyclin dependent kinase Kin28.; Similarity: the encoded protein belongs to the HIT superfamily. HINT subfamily.; Title: similarity to histidine triad protein Hnt1 -Saccharomyces cerevisiae; See PMID 10958787; See PMID 11805111; uncharacterized protein 473473 4981188 An06g01890 Aspergillus niger uncharacterized protein XP_001391010.1 472352 D 5061 CDS An06g01900 4981189 complement(join(473816..474306,474359..474458,474508..474549,474600..475394)) VIII 1 NT_166522.1 Remark: a splice site was detected upstream of the START codon.; Remark: the expression of Ssh2 from Glycine max in S. cerevisiae bypasses the requirement for an essential phosphatidylinositoltransfer protein in Golgi secretory function.; Similarity: the ORF coding protein showes the strongest similarity the S. pombe hypothetical protein SPAC3H8. 02 and to the S. cerevisie hypothetical protein YLR380w which are both similar to proteins of the Sec14 family.; Title: similarity to polyphosphoinositide binding protein Ssh2p - Glycine max; See PMID 9670016; uncharacterized protein 475394 4981189 An06g01900 Aspergillus niger uncharacterized protein XP_001391011.3 473816 R 5061 CDS An06g01910 4981190 join(476461..476775,477063..477509) VIII 1 NT_166522.1 Remark: A GFP-Dam1p fusion protein expressed in S. cerevisiae revealed a Dam1p association with the intranuclear spindle microtubules and the spindle pole bodies in vivo.; Title: similarity to microtubule-associated protein Dam1 - Saccharomyces cerevisiae; See PMID 9817759; uncharacterized protein 477509 4981190 An06g01910 Aspergillus niger uncharacterized protein XP_059605301.1 476461 D 5061 CDS An06g01920 4981191 join(478567..478618,478685..478924,478974..479081,479132..479460,479517..479942,479997..480200,480257..480370) VIII 1 NT_166522.1 Catalytic activity: Ubiquitin C-terminal thiolester + H(2)O <=> ubiquitin + a thiol.; Remark: USP3 from Homo sapiens is a deubiquitinating enzyme.; Title: strong similarity to ubiquitin specific protease 3 USP3 - Homo sapiens; See PMID 10480896; uncharacterized protein 480370 4981191 An06g01920 Aspergillus niger uncharacterized protein XP_001391013.1 478567 D 5061 CDS An06g01930 4981192 complement(join(481588..481596,481849..481905,481990..482032,482166..482189,482259..482296)) VIII 1 NT_166522.1 Similarity: the ORF is longer than S29 of S. cerevisiae (94 compared to 56 amino acids).; Similarity: the ORF sequence is nearly idenical to EMBLEST:AN743 from Aspergillus niger which shows strong similarity to a s29 similar mRNA.; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S29 - Saccharomyces cerevisiae; cytoplasm; See PMID 9396790; See PMID 9421530; 40S ribosomal protein uS14 482296 4981192 An06g01930 Aspergillus niger 40S ribosomal protein uS14 XP_001391014.1 481588 R 5061 CDS An06g01940 84591203 complement(join(483413..483451,483497..483544,483672..483690,483802..483970,484251..484254)) VIII 1 NT_166522.1 hypothetical protein 484254 84591203 An06g01940 Aspergillus niger hypothetical protein XP_059605302.1 483413 R 5061 CDS An06g01950 4981194 join(489501..489762,489825..490393) VIII 1 NT_166522.1 Title: similarity to hypothetical protein SPBC3B8.06 - Schizosaccharomyces pombe; uncharacterized protein 490393 4981194 An06g01950 Aspergillus niger uncharacterized protein XP_001391016.1 489501 D 5061 CDS An06g01960 4981195 join(490786..491262,491324..491914) VIII 1 NT_166522.1 Catalytic activity: a nitrile + H(2)O <=> a carboxylate + NH(3).; Function: the A. thaliana homolog NIT2 encodes a nitrilase that converts indole-3-acetonitrile to the plant hormone indole-3-acetic acid.; Title: strong similarity to nitrilase NIT2 -Arabidopsis thaliana; See PMID 8016109; See PMID 8022831; See PMID 1555601; uncharacterized protein 491914 4981195 An06g01960 Aspergillus niger uncharacterized protein XP_001391017.1 490786 D 5061 CDS An06g01970 4981196 join(493234..493620,493674..494129,494184..494774) VIII 1 NT_166522.1 Remark: ORF encoded protein belongs to the fungal binuclear zinc cluster family.; Remark: S. cerevisiae PPR1 gene product is a pyrimidin pathway regulating transcription factor.; Title: similarity to regulator protein Ppr1 -Saccharomyces cerevisiae; See PMID 9858611; uncharacterized protein 494774 4981196 An06g01970 Aspergillus niger uncharacterized protein XP_001391018.3 493234 D 5061 CDS An06g01980 4981197 complement(join(496368..496412,496504..496734,496791..497038,497095..497389)) VIII 1 NT_166522.1 Function: tetrahydroxynaphthalene reductase of Pyricularia grisea is involved in the melanin biosynthesis; Remark: Magnaporthe grisea (=Pyricularia grisea) mutants lacking activities for both trihydroxynaphthalene and tetrahydroxynaphthalene reductases do not produce scytalone, indicating that there are no other metabolic routes to scytalone.; Remark: tetrahydroxynaphthalene reductase of Pyricularia grisea: protein_id AAG29497. 1.; Title: strong similarity to tetrahydroxynaphthalene reductase - Pyricularia grisea; See PMID 10956664; uncharacterized protein 497389 4981197 An06g01980 Aspergillus niger uncharacterized protein XP_001391019.3 496368 R 5061 CDS An06g01990 4981198 complement(join(497840..498617,498668..498884,499089..499140)) VIII 1 NT_166522.1 Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529; uncharacterized protein 499140 4981198 An06g01990 Aspergillus niger uncharacterized protein XP_059605303.1 497840 R 5061 CDS An06g02000 4981199 complement(join(500946..501008,501068..501792,502456..502468,502532..502763,502817..503418)) VIII 1 NT_166522.1 Catalytic activity: (3R)-3-hydroxyacyl-[acyl-carrier protein]+NADP(+)<=>3-oxoacyl-[acyl-carrier protein]+NADPH.; Complex: the Clkr27 gene product from Cuphea lanceolata is integral part of the fatty acid synthase type II.; Pathway: the Clkr27 gene product from Cuphea lanceolata is involved in the fatty acid biosynthesis.; Remark: Only the c-terminal part of the ORF encoded protein (~aa280-aa544) shows significant similarity to the Clkr27 gene product from Cuphea lanceolata. The n-terminal part (aa1-aa206) is significant similar to the probable phosphoglycolate phosphatase BH3587 from Bacillus halodurans. The conection of both ORFs could be caused by a putative sequencing error.; Title: similarity to 3-oxoacyl-(acyl-carrier-protein) reductase Clkr27 - Cuphea lanceolata [putative sequencing error]; See PMID 1376402; uncharacterized protein 503418 4981199 An06g02000 Aspergillus niger uncharacterized protein XP_059605304.1 500946 R 5061 CDS An06g02010 4981200 504322..505137 VIII 1 NT_166522.1 Catalytic activity: RX+glutathione<=>HX+R-S-glutathione.; Remark: glutathione s-transferases are a group of enzymes of broad specificity. R may be an aliphatic,aromatic or heterocyclic group. X may be a sulfate, nitrite or halide group. Also catalyses the addition of aliphatic epoxides and arene oxides to glutathione; the reduction of polyol nitrate by glutathione to polyol and nitrite; certain isomerization reactions and disulfide interchange.; Remark: the URE2 gene product of S. cerevisiae plays an important role in the cellular response to the nitrogen source and has homology to glutathione s-transferases.; Similarity: the ORF encoded protein shows strong similarities to many glutathione transferase homologs.; Title: strong similarity to glutathione transferase homolog Ure2 - Saccharomyces cerevisiae; See PMID 1990286; See PMID 8896273; uncharacterized protein 505137 4981200 An06g02010 Aspergillus niger uncharacterized protein XP_001391022.3 504322 D 5061 CDS An06g02020 4981201 join(505627..505784,505861..506887,506956..507076,507137..507270) VIII 1 NT_166522.1 Remark: The expression of the C. albicans FLU1 gene in the S. cerevisiae strain YKKB-13 mediated not only resistance to fluconazole but also to cycloheximide among the different drugs tested.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; plasma membrane; See PMID 11065353; uncharacterized protein 507270 4981201 An06g02020 Aspergillus niger uncharacterized protein XP_001391023.1 505627 D 5061 CDS An06g02030 4981202 complement(507582..509114) VIII 1 NT_166522.1 Induction: Mst-1 upregulated in ectomycorrhizas by a monosaccharide-controlled mechanism.; Title: strong similarity to monosaccharide transporter AmMst-1 - Amanita muscaria; plasma membrane; See PMID 9487692; uncharacterized protein 509114 4981202 An06g02030 Aspergillus niger uncharacterized protein XP_001391024.1 507582 R 5061 CDS An06g02040 4981203 509962..512559 VIII 1 NT_166522.1 Catalytic activity: enzyme class is involved in hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose.; Remark: the enzyme class shows a wide specificity for beta-D-glucosides. Some examples also hydrolyse one or more of the following: beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, and beta-D-fucosides.; Title: strong similarity to beta-glucosidase cbg1 -Agrobacterium tumefaciens; See PMID 1537792; uncharacterized protein 512559 4981203 An06g02040 Aspergillus niger uncharacterized protein XP_001391025.1 509962 D 5061 CDS An06g02050 4981204 join(512882..513014,513123..514447) VIII 1 NT_166522.1 Remark: ORF encodes a probable transcriptional regulator of the fungal binuclear zinc cluster type.; Title: strong similarity to hypothetical protein CAD37157.1 - Aspergillus fumigatus; uncharacterized protein 514447 4981204 An06g02050 Aspergillus niger uncharacterized protein XP_059605305.1 512882 D 5061 CDS An06g02060 4981205 join(516374..516464,516630..517519,517636..517709,517783..517969) VIII 1 NT_166522.1 Catalytic activity: successive hydrolysis of beta-D-glucose units from the non-reducing ends of 1,3-beta-D-glucans, releasing alpha-glucose.; Title: similarity to exo-1,3-beta-glucanase/1,3-beta-D-glucan glucanohydrolase EXG1 - Yarrowia lipolytica; extracellular/secretion proteins; See PMID 10572260; uncharacterized protein 517969 4981205 An06g02060 Aspergillus niger uncharacterized protein XP_059605306.1 516374 D 5061 CDS An06g02070 4981206 complement(join(519773..519962,520013..520245,520304..521260)) VIII 1 NT_166522.1 Function: pectinolytic enzyme RhgA from Aspergillus aculeatus has a positive effect in the apple hot-mash liquefaction process. It hydrolyzes alpha-D-galacturonopyranosyl-(1,2)-alpha-L-rhamnopyranosyl linkages in the backbone of the hairy regions of pectins. Optimal pH is 3. 5, enzymatic activity becomes unstable above pH 6. 0; optimal temperature is around 30-50 degrees celsius.; Title: strong similarity to rhamnogalacturonase rhgA - Aspergillus aculeatus; extracellular/secretion proteins; See PMID 7576553; See PMID 7961884; See PMID 8720076; See PMID 9115442; uncharacterized protein 521260 4981206 An06g02070 Aspergillus niger uncharacterized protein XP_001391028.1 519773 R 5061 CDS An06g02080 4981207 522948..524030 VIII 1 NT_166522.1 Remark: a putative sequencing error leads to an premature STOP codon.; Remark: the LovC protein is responsible for modulation of polyketide synthase activity in Aspergillus terreus.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus [putative sequencing error]; putative sequencing error; See PMID 10334994; uncharacterized protein 524030 4981207 An06g02080 Aspergillus niger uncharacterized protein XP_059605307.1 522948 D 5061 CDS An06g02090 4981208 complement(join(524660..524974,525027..525274,525326..525486,525556..526088)) VIII 1 NT_166522.1 Catalytic activity: Trans-trans-farnesyl diphosphate+isopentenyl diphosphate<=>diphosphate+geranylgeranyl diphosphate; Similarity: the ORF coded protein shows strongest similarity to CarG (geranylgeranyl pyrophosphate synthase) of Mucor circinelloides, which funtional evidence is shown,but still unpublished.; Title: strong similarity to geranylgeranyl pyrophosphate synthase GGPPS - Gibberella fujikuroi; See PMID 9230902; uncharacterized protein 526088 4981208 An06g02090 Aspergillus niger uncharacterized protein XP_059605308.1 524660 R 5061 CDS An06g02100 84591204 complement(join(526389..526661,526712..526737,526791..527073)) VIII 1 NT_166522.1 Title: weak similarity to hypothetical protein encoded by An03g02050 - Aspergillus niger; uncharacterized protein 527073 84591204 An06g02100 Aspergillus niger uncharacterized protein XP_059605309.1 526389 R 5061 CDS An06g02110 84591205 complement(528113..528997) VIII 1 NT_166522.1 Remark: closest manual Blastp hit nompC D. melanogaster shows an E. val of 5e-21.; Remark: nompC from Drosophila melanogaster encodes a new ion channel that is essential for mechanosensory transduction.; Title: similarity to protein nompC - Drosophila melanogaster; See PMID 10744543; uncharacterized protein 528997 84591205 An06g02110 Aspergillus niger uncharacterized protein XP_059605310.1 528113 R 5061 CDS An06g02120 4981211 join(529324..529597,529687..529818,529854..530035,530094..530414) VIII 1 NT_166522.1 Remark: Tyk2 from mouse belongs to Jak (Janus) family and contains Jak homology.; Title: weak similarity to Tyk2 non-receptor tyrosine - Mus musculus; See PMID 10374907; uncharacterized protein 530414 4981211 An06g02120 Aspergillus niger uncharacterized protein XP_001391033.3 529324 D 5061 CDS An06g02130 84591206 complement(530831..531121) VIII 1 NT_166522.1 hypothetical protein 531121 84591206 An06g02130 Aspergillus niger hypothetical protein XP_059605311.1 530831 R 5061 CDS An06g02140 84591207 complement(531750..532418) VIII 1 NT_166522.1 Title: similarity to hypothetical protein encoded by An01g07970 - Aspergillus niger; uncharacterized protein 532418 84591207 An06g02140 Aspergillus niger uncharacterized protein XP_059605312.1 531750 R 5061 CDS An06g02150 4981214 join(532919..533451,533762..534859,534932..535106) VIII 1 NT_166522.1 Similarity: N-terminal third shows similarity to C-terminal two-thirds of An01g11330.; Title: similarity to hypothetical protein CAD70322.1 - Neurospora crassa; uncharacterized protein 535106 4981214 An06g02150 Aspergillus niger uncharacterized protein XP_001391036.3 532919 D 5061 CDS An06g02160 4981215 536655..538214 VIII 1 NT_166522.1 Title: strong similarity to hypothetical protein CC0505 - Caulobacter crescentus; uncharacterized protein 538214 4981215 An06g02160 Aspergillus niger uncharacterized protein XP_059605313.1 536655 D 5061 CDS An06g02170 4981216 complement(539703..540728) VIII 1 NT_166522.1 Remark: Picea glauca=white spruce.; Remark: the EMB34 transcript during somatic embryo accumulates development of Picea glauca.; Title: similarity to embryonic abundant protein EMB34 - Picea glauca; See PMID 10350098; uncharacterized protein 540728 4981216 An06g02170 Aspergillus niger uncharacterized protein XP_001391038.1 539703 R 5061 CDS An06g02180 4981217 join(543806..544068,544238..544937,544983..545064,545166..545188,545260..545756,545815..545870,545931..546109,546166..546341,546397..546423,546485..546853,547107..547165,547244..547438,547494..547620,547674..547765,547830..548146) VIII 1 NT_166522.1 Title: weak similarity to Traf2 and NCK interacting kinase (splice variant 8) - Homo sapiens; See PMID 10521462; uncharacterized protein 548146 4981217 An06g02180 Aspergillus niger uncharacterized protein XP_059605314.1 543806 D 5061 CDS An06g02190 84591208 complement(join(548835..548881,549125..549303,549628..549635)) VIII 1 NT_166522.1 Title: questionable ORF; uncharacterized protein 549635 84591208 An06g02190 Aspergillus niger uncharacterized protein XP_059605315.1 548835 R 5061 CDS An06g02200 84591209 550446..551744 VIII 1 NT_166522.1 Title: weak similarity to hypothetical multicopper oxidase precursor encoded by SPAC1F7.08 -Schizosaccharomyces pombe; uncharacterized protein 551744 84591209 An06g02200 Aspergillus niger uncharacterized protein XP_059605316.1 550446 D 5061 CDS An06g02210 4981220 join(553775..554732,554792..554939,554994..556206) VIII 1 NT_166522.1 Remark: the ORF coded protein also show similarity to patent:PATENTPROT:R74205: Human death associated protein DAP-2.; Remark: the mouse inversin gene is involved in the left-right axis pathway in the vertebrate development.; Title: similarity to protein inversin - Homo sapiens; See PMID 9771707; uncharacterized protein 556206 4981220 An06g02210 Aspergillus niger uncharacterized protein XP_001391042.3 553775 D 5061 CDS An06g02220 84591210 join(556874..556908,556952..557216) VIII 1 NT_166522.1 hypothetical protein 557216 84591210 An06g02220 Aspergillus niger hypothetical protein XP_059605317.1 556874 D 5061 CDS An06g02230 84591211 complement(join(557851..557944,558114..558427)) VIII 1 NT_166522.1 Title: weak similarity to hypothetical protein encoded by An11g05560 - Aspergillus niger; uncharacterized protein 558427 84591211 An06g02230 Aspergillus niger uncharacterized protein XP_059605318.1 557851 R 5061 CDS An06g02240 84591212 join(561003..561096,561150..561841) VIII 1 NT_166522.1 Similarity: blast hits are caused by repetetive sequence motives.; Title: weak similarity to hypothetical protein AAL31335.1 - African swine fever virus; uncharacterized protein 561841 84591212 An06g02240 Aspergillus niger uncharacterized protein XP_059605319.1 561003 D 5061 CDS An06g02250 84591213 complement(join(562242..562291,562335..562350,562560..562613,562747..562871,563234..563273,563510..563534,563656..563669,563815..563942,564020..564045,564079..564122)) VIII 1 NT_166522.1 hypothetical protein 564122 84591213 An06g02250 Aspergillus niger hypothetical protein XP_059605320.1 562242 R 5061 CDS An06g02260 84591214 join(564626..564699,564878..564952,565163..565352) VIII 1 NT_166522.1 hypothetical protein 565352 84591214 An06g02260 Aspergillus niger hypothetical protein XP_059605321.1 564626 D 5061 CDS An06g02268 84591215 join(569262..569438,569505..569627) VIII 1 NT_166522.1 hypothetical protein 569627 84591215 An06g02268 Aspergillus niger hypothetical protein XP_059605322.1 569262 D 5061 CDS An06g02270 4981227 570218..571909 VIII 1 NT_166522.1 Title: similarity to arabinose transport protein araE - Escherichia coli; plasma membrane; See PMID 2836407; See PMID 6319708; uncharacterized protein 571909 4981227 An06g02270 Aspergillus niger uncharacterized protein XP_001391049.1 570218 D 5061 CDS An06g02280 84591216 join(572342..572350,572572..572788,572869..572931,573374..573414,573449..573566,573705..573846,573987..574158) VIII 1 NT_166522.1 Title: similarity to transesterase lovD -Aspergillus terreus; See PMID 10334994; See PMID 11386351; uncharacterized protein 574158 84591216 An06g02280 Aspergillus niger uncharacterized protein XP_059605323.1 572342 D 5061 CDS An06g02290 10098298 complement(join(577159..577544,577597..577661,577712..577937,578002..578091,578290..578485)) VIII 1 NT_166522.1 Similarity: shows weak similarity to integral membrane protein PTH11 of Magnaporthe grisea.; Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea; uncharacterized protein 578485 10098298 An06g02290 Aspergillus niger uncharacterized protein XP_059605324.1 577159 R 5061 CDS An06g02300 84591217 complement(join(579792..579825,579890..579935,580050..580182)) VIII 1 NT_166522.1 hypothetical protein 580182 84591217 An06g02300 Aspergillus niger hypothetical protein XP_059605325.1 579792 R 5061 CDS An06g02310 4981231 join(584316..584610,584700..585121) VIII 1 NT_166522.1 Title: weak similarity to protein 763 from patent FR2807064-A1 - Magnaporthe grisea; uncharacterized protein 585121 4981231 An06g02310 Aspergillus niger uncharacterized protein XP_059605326.1 584316 D 5061 CDS An06g02320 84591218 complement(join(586215..586592,586794..586862,586926..587014,587093..587225)) VIII 1 NT_166522.1 hypothetical protein 587225 84591218 An06g02320 Aspergillus niger hypothetical protein XP_059605327.1 586215 R 5061 CDS An06g02330 84591219 588882..589151 VIII 1 NT_166522.1 hypothetical protein 589151 84591219 An06g02330 Aspergillus niger hypothetical protein XP_059605328.1 588882 D 5061 CDS An06g02340 4981234 complement(join(589477..590226,590300..590378,590464..590597)) VIII 1 NT_166522.1 Catalytic activity: D-Amino acid + H2O + O2 = 2-Oxo acid + NH3 + H2O2.; Title: similarity to D-amino-acid oxidase DAO -Fusarium solani; plasma membrane; See PMID 1982443; uncharacterized protein 590597 4981234 An06g02340 Aspergillus niger uncharacterized protein XP_059605329.1 589477 R 5061 CDS An06g02350 4981235 join(590960..591108,591294..591451,591558..592219,592277..592438) VIII 1 NT_166522.1 Title: strong similarity to hypothetical membrane protein YDL144c - Saccharomyces cerevisiae; uncharacterized protein 592438 4981235 An06g02350 Aspergillus niger uncharacterized protein XP_001391057.3 590960 D 5061 CDS An06g02360 84591220 complement(join(592765..593596,593724..593781,593948..593995,594155..594200,594393..594445,594490..594493,594567..594638)) VIII 1 NT_166522.1 Function: NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase from H. sapiens catalyzes the oxidation of many prostaglandins.; Title: similarity to NAD-dependent 15-hydroxyprostaglandin dehydrogenase NAD - Homo sapiens; See PMID 2337593; See PMID 1697582; uncharacterized protein 594638 84591220 An06g02360 Aspergillus niger uncharacterized protein XP_059605330.1 592765 R 5061 CDS An06g02370 4981237 join(595192..595233,595313..596215) VIII 1 NT_166522.1 Title: strong similarity to hypothetical protein SPAC17A3.08 - Schizosaccharomyces pombe; uncharacterized protein 596215 4981237 An06g02370 Aspergillus niger uncharacterized protein XP_001391059.3 595192 D 5061 CDS An06g02380 4981238 join(596405..596632,596779..596825,596889..597203,597670..598156,598268..598404,598537..598603) VIII 1 NT_166522.1 Title: weak similarity to hypothetical protein encoded by An05g00020 - Aspergillus niger; uncharacterized protein 598603 4981238 An06g02380 Aspergillus niger uncharacterized protein XP_059605331.1 596405 D 5061 CDS An06g02390 84591221 join(599733..599867,599948..600271) VIII 1 NT_166522.1 Title: weak similarity to hypothetical protein EAA61302.1 - Aspergillus nidulans; uncharacterized protein 600271 84591221 An06g02390 Aspergillus niger uncharacterized protein XP_059605332.1 599733 D 5061 CDS An06g02400 4981240 602683..604047 VIII 1 NT_166522.1 Title: strong similarity to hypothetical protein encoded by SMb20234 - Sinorhizobium meliloti; uncharacterized protein 604047 4981240 An06g02400 Aspergillus niger uncharacterized protein XP_001391062.1 602683 D 5061 CDS An06g02410 84591222 complement(join(605773..605834,605958..606171)) VIII 1 NT_166522.1 hypothetical protein 606171 84591222 An06g02410 Aspergillus niger hypothetical protein XP_059600810.1 605773 R 5061 CDS An06g02420 4981242 join(607567..607690,607749..609430) VIII 1 NT_166522.1 Catalytic activity: hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides.; EC:3.2.1.26; Remark: substrates include sucrose. Also catalyses fructotransferase reactions.; Title: strong similarity to beta-fructofuranosidase precursor suc1 - Aspergillus niger; uncharacterized protein 609430 4981242 An06g02420 Aspergillus niger uncharacterized protein XP_001391064.3 607567 D 5061 CDS An06g02430 4981243 join(610920..611019,611234..611458,611556..611760,611829..612145,612230..613284) VIII 1 NT_166522.1 Title: similarity to hypothetical protein EAA69435.1 - Gibberella zeae; uncharacterized protein 613284 4981243 An06g02430 Aspergillus niger uncharacterized protein XP_059600811.1 610920 D 5061 CDS An06g02450 4981244 complement(join(615824..616374,616428..616627,616693..616773,616832..617675,617773..618143,618202..618284,618417..618917)) VIII 1 NT_166522.1 Title: similarity to hypothetical protein CAD70808.1 - Neurospora crassa; uncharacterized protein 618917 4981244 An06g02450 Aspergillus niger uncharacterized protein XP_059600812.1 615824 R 5061 CDS An06g02460 4981245 join(623444..624524,624676..624753,624857..625133,625204..625228,625263..625277) VIII 1 NT_166522.1 Title: similarity to hypothetical beta-hexosamidase A precursor BH0675 - Bacillus halodurans; uncharacterized protein 625277 4981245 An06g02460 Aspergillus niger uncharacterized protein XP_001391067.3 623444 D 5061 CDS An06g02470 4981246 625759..627087 VIII 1 NT_166522.1 Similarity: the ORF encoded protein shows also similarities to hypothetical beta-lactamases from other organisms.; Title: strong similarity to protein #695 from patent WO200177335-A2 - Listeria monocytogenes; uncharacterized protein 627087 4981246 An06g02470 Aspergillus niger uncharacterized protein XP_001391068.1 625759 D 5061 CDS An06g02480 4981247 complement(join(627280..627337,627392..627726,627779..628073,628128..628548,628604..628805,628878..629404,629472..629475)) VIII 1 NT_166522.1 Title: similarity to putative transcriptional regulator CAF32162.1 - Aspergillus fumigatus; uncharacterized protein 629475 4981247 An06g02480 Aspergillus niger uncharacterized protein XP_059600813.1 627280 R 5061 CDS An06g02490 4981248 complement(join(630064..630513,630555..630664,630721..631047,631103..631208,631270..631572)) VIII 1 NT_166522.1 Title: strong similarity to hypothetical protein ybbC - Bacillus subtilis; uncharacterized protein 631572 4981248 An06g02490 Aspergillus niger uncharacterized protein XP_059600814.1 630064 R 5061 CDS An06g02500 4981249 complement(join(632889..632923,632978..633969,634020..634405,634470..634923,634985..635223)) VIII 1 NT_166522.1 Title: strong similarity to cellular proliferation protein #230 from patent WO200170955-A2 - Escherichia coli; uncharacterized protein 635223 4981249 An06g02500 Aspergillus niger uncharacterized protein XP_059600815.1 632889 R 5061 CDS An06g02510 4981250 join(635937..636047,636122..636329,636390..637450) VIII 1 NT_166522.1 Title: similarity to hypothetical protein SPAC922.05c - Schizosaccharomyces pombe; uncharacterized protein 637450 4981250 An06g02510 Aspergillus niger uncharacterized protein XP_001391072.3 635937 D 5061 CDS An06g02520 84591223 join(638073..638082,638192..638259,638324..638362,638538..638900,639051..639077) VIII 1 NT_166522.1 Title: weak similarity to hypothetical protein Mx homolog - Equus caballus; uncharacterized protein 639077 84591223 An06g02520 Aspergillus niger uncharacterized protein XP_059600816.1 638073 D 5061 CDS An06g02530 4981252 complement(join(640611..641462,641524..643468,643544..643823,643894..643974,644054..644104,644211..644277)) VIII 1 NT_166522.1 Remark: Fusarium oxysporum fatty-acid hydroxylase CYP505 is a membrane-bound eukaryotic counterpart of Bacillus megaterium cytochrome P450BM3, a fused protein of cytochrome P450 and its reductase.; Title: strong similarity to fatty acid omega-hydroxylase CYP505 - Fusarium oxysporum; See PMID 8830036; See PMID 10995755; uncharacterized protein 644277 4981252 An06g02530 Aspergillus niger uncharacterized protein XP_001391074.3 640611 R 5061 CDS An06g02540 4981253 complement(join(644949..645080,645151..645588,645662..645763)) VIII 1 NT_166522.1 hypothetical protein 645763 4981253 An06g02540 Aspergillus niger hypothetical protein XP_001391075.3 644949 R 5061 CDS An06g02550 4981254 join(646544..647126,647251..647304,647362..647702,647825..647882,647935..648156,648465..649080,649152..649506,649572..650142,650209..650588,650661..650850,650924..651197,651306..651544,651590..651714) VIII 1 NT_166522.1 Remark: Phytopathogenic fungi such as the fungal plant pathogen Magnaporthe grisea encounter toxic environments during plant invasion as a result of the plant defense response. The pathogenicity factor ABC1 is an ATP-driven efflux pump of the ATP-binding cassette (ABC) superfamily of membrane transporters which is requried for pathogenesis, most likely to protect itself against plant defense mechanisms.; Title: similarity to ABC transporter ABC1 -Magnaporthe grisea; See PMID 9927411; uncharacterized protein 651714 4981254 An06g02550 Aspergillus niger uncharacterized protein XP_059600817.1 646544 D 5061 CDS An06g02560 84591224 join(652341..652426,652480..652618,652727..652841,652976..653046) VIII 1 NT_166522.1 hypothetical protein 653046 84591224 An06g02560 Aspergillus niger hypothetical protein XP_059600818.1 652341 D 5061 CDS An06g02570 4981256 complement(join(654947..655019,655052..655269,655327..655627,655717..656216,656301..656531,656579..656593,656644..656909,657012..657230,657292..657307,657370..657530,657590..657659,657728..657765,657829..657982)) VIII 1 NT_166522.1 Function: the nit-4 protein from N. crassa is a pathway-specific regulatory transcription factor the of nitrate assimilation. It activates the transcription of the genes for nitrate and nitrite reductases.; Similarity: the N. crassa nit-4 protein is a DNA-binding transcriptional regulator of the fungal Zn(II)2Cys6 binuclear-zinc-cluster type.; Title: similarity to nitrogen assimilation regulatory protein nit-4 - Neurospora crassa; nucleus; See PMID 1388109; See PMID 1531376; See PMID 1840634; uncharacterized protein 657982 4981256 An06g02570 Aspergillus niger uncharacterized protein XP_059600819.1 654947 R 5061 CDS An06g02580 84591225 complement(join(<658656..658994,659055..659174)) VIII 1 NT_166522.1 Function: in C maltosa each of four individual P450alk isoforms is alone sufficient to allow growth on long chain n-alkane.; Function: n-alkane-assimilating yeast contain multiple P450alk genes, which are essential for n-alkane assimilation and are assumed to catalyze terminal hydroxylation of n-alkanes in the assimilation pathway.; Induction: C. tropicalis P450alk2 is alkane-inducible and is induced by tetradecane when C. tropicalis was grown on this carbon source.; Remark: ORF 3'truncated due to end of contig.; Similarity: C. tropicalis P450alk2 is a member of the P450LII/CYP52 gene family.; Title: similarity to cytochrome P450alk2 - Candida tropicalis [truncated ORF]; See PMID 9461581; uncharacterized protein 659174 84591225 An06g02580 Aspergillus niger uncharacterized protein XP_059603806.1 658656 R 5061 CDS An06g02590 84591226 join(659729..659744,659872..660356,660384..660516,660620..660750) VIII 1 NT_166522.1 Similarity: the C-terminal region of the predicted A. niger protein shows similarity to several predicted monooxygenase proteins and contains a flavoprotein COGs domain.; Title: similarity to hypothetical lavin-containing monooxygenase BAC46634 - Bradyrhizobium japonicum; uncharacterized protein 660750 84591226 An06g02590 Aspergillus niger uncharacterized protein XP_059603807.1 659729 D 5061 CDS An06g02600 84591227 join(660793..660795,660968..661533,661899..662076) VIII 1 NT_166522.1 Title: similarity to protein fragment SEQ ID NO:6682 from patent EP1108790-A2 - Corynebacterium glutamicum; uncharacterized protein 662076 84591227 An06g02600 Aspergillus niger uncharacterized protein XP_059603808.1 660793 D 5061 CDS An06g02610 4981260 complement(join(<662218..662557,662627..662958,663029..663032)) VIII 1 NT_166522.1 Function: V. harveyi fabG is involved in fatty acid biosynthesis.; Remark: possible sequencing error at position 3802 leading to a frameshift.; Similarity: the predicted A. niger protein also shows similarity to Pseudomonas paucimobilis linC, a 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase and member of the short-chain alcohol dehydrogenase family.; Title: similarity to 3-ketoacyl-(acyl carrier protein) reductase fabG - Vibrio harveyi [putative frameshift]; putative frameshift; See PMID 7515041; See PMID 8550484; uncharacterized protein 663032 4981260 An06g02610 Aspergillus niger uncharacterized protein XP_059603809.1 662218 R 5061 CDS An06g02620 84591228 complement(join(<663266..663645,663737..664063,664173..664331,664515..664753)) VIII 1 NT_166522.1 Catalytic activity: N. crassa al-3 converts Trans-trans-farnesyl diphosphate + isopentenyl diphosphate to diphosphate + geranylgeranyl diphosphate.; Function: N. crassa al-3 is a carotenoid biosynthetic enzyme.; Induction: N. crassa al-3 is not expressed in the dark and its transcription is induced by blue light.; Remark: possible sequencing errors at positons 5006 and 4882 leading to frameshifts.; Title: strong similarity to geranylgeranyl pyrophosphate synthase al-3 - Neurospora crassa [putative frameshift]; putative frameshift; See PMID 1826006; uncharacterized protein 664753 84591228 An06g02620 Aspergillus niger uncharacterized protein XP_059603810.1 663266 R 5061 CDS An06g02630 84591229 join(665127..665142,665259..665350,665415..665449,665488..665501,665588..665718,665768..>666129) VIII 1 NT_166522.1 Remark: the predicted A. niger protein contains possible sequencing errors at positions 7195, 7261 and 7305 resulting in internal stopcodons and frame shifts.; Remark: the predicted A. niger protein has been classified as putative pseudogene due to its fragmental ORF size and several internal stopcodons and frame shifts.; Similarity: similarity is from the C-terminal half of the predicted A. niger protein to a central region of M. grisea MAGGY Pol, which is 1000 aa longer.; Title: similarity to MAGGY LTR retrotransposon Pol -Magnaporthe grisea [putative pseudogene] [putative frameshift]; putative frameshift; uncharacterized protein 666129 84591229 An06g02630 Aspergillus niger uncharacterized protein XP_059603811.1 665127 D 5061 CDS An06g02640 4981263 666884..667822 VIII 1 NT_166522.1 Title: strong similarity to hypothetical protein AAK01512.1 - Pseudomonas aeruginosa; uncharacterized protein 667822 4981263 An06g02640 Aspergillus niger uncharacterized protein XP_001391085.1 666884 D 5061 CDS An06g02650 4981264 complement(join(668450..669139,669194..669341,669417..670159)) VIII 1 NT_166522.1 Similarity: the predicted A. niger protein contains PFAM and COGs hydrolase motifs.; Title: strong similarity to hypothetical protein CAD70532.1 - Neurospora crassa; uncharacterized protein 670159 4981264 An06g02650 Aspergillus niger uncharacterized protein XP_059603812.1 668450 R 5061 CDS An06g02660 4981265 671492..673105 VIII 1 NT_166522.1 Function: eln2 of C. cinereus encodes a novel type of microsomal cytochrome P450 enzyme, which is involved in mushroom morphogenesis.; Localization: C. cinereus eln2 localises to the microsomal compartment.; Phenotype: a dominant mutation of the elongationless2 (eln2) gene of the mushroom C. cinereus affects pattern formation in the development of fruit body primordia, causing dumpy primordia which culminate in mature fruit bodies with short stipes.; Similarity: the ORF shows similarity to several cytochrome p450 related proteins from different species,which have different cellular functions.; Title: strong similarity to cytochrome P450 eln2 -Coprinus cinereus; See PMID 10779399; uncharacterized protein 673105 4981265 An06g02660 Aspergillus niger uncharacterized protein XP_001391087.3 671492 D 5061 CDS An06g02670 4981266 complement(join(673297..673504,673598..673770,673854..675119)) VIII 1 NT_166522.1 Function: F. sporotrichioides TRI11 is required for C-15 hydroxylation in trichothecene myotoxin biosynthesis.; Function: disruption of F. sporotrichioides TRI11 results in an altered trichothecene production phenotype characterized by the accumulation of isotrichodermin, a trichothecene pathway intermediate.; Remark: trichothecenes are sesquiterpenoid mycotoxins and act as protein synthesis inhibitors for eukaryotic organisms.; Similarity: F. sporotrichioides TRI11 defines a cytochrome P-450 gene family, designated CYP65A1; Title: strong similarity to cytochrome P450 monooxygenase TRI11 - Fusarium sporotrichioides; See PMID 9435078; uncharacterized protein 675119 4981266 An06g02670 Aspergillus niger uncharacterized protein XP_001391088.1 673297 R 5061 CDS An06g02680 4981267 complement(675286..675876) VIII 1 NT_166522.1 Similarity: the predicted A. niger protein contains a PFAM hydrolase motif.; Title: similarity to hypothetical protein CAD70532.1 - Neurospora crassa; uncharacterized protein 675876 4981267 An06g02680 Aspergillus niger uncharacterized protein XP_001391089.1 675286 R 5061 CDS An06g02690 84591230 complement(join(676198..676782,676857..676955)) VIII 1 NT_166522.1 Title: similarity to protein sequence #10741 from patent WO200175067-A2 - Homo sapiens; uncharacterized protein 676955 84591230 An06g02690 Aspergillus niger uncharacterized protein XP_059603813.1 676198 R 5061 CDS An06g02700 4981269 complement(677569..679122) VIII 1 NT_166522.1 Function: eln2 of C. cinereus encodes a novel type of microsomal cytochrome P450 enzyme, which is involved in mushroom morphogenesis.; Localization: C. cinereus eln2 localises to the microsomal compartment.; Phenotype: a dominant mutation of the elongationless2 (eln2) gene of the mushroom C. cinereus affects pattern formation in the development of fruit body primordia, causing dumpy primordia which culminate in mature fruit bodies with short stipes.; Similarity: the ORF shows similarity to several cytochrome p450 related proteins from different species,which have different cellular functions.; Title: strong similarity to cytochrome P450 eln2 -Coprinus cinereus; See PMID 10779399; uncharacterized protein 679122 4981269 An06g02700 Aspergillus niger uncharacterized protein XP_001391091.1 677569 R 5061 CDS An06g02710 4981270 680009..>680850 VIII 1 NT_166522.1 Catalytic activity: cyclohexanol dehydrogenases convert cyclohexanol + NAD(+) to cyclohexanone + NADH.; Function: Acinetobacter chnA is involved in the utilisation of cyclohexanol as a carbon source.; Remark: possible sequencing error at position 21812 leading to a frameshift.; Title: strong similarity to cyclohexanol dehydrogenase chnA - Acinetobacter sp. [putative frameshift]; putative frameshift; See PMID 10940013; uncharacterized protein 680850 4981270 An06g02710 Aspergillus niger uncharacterized protein XP_059603814.1 680009 D 5061 CDS An06g02730 84591231 join(683010..683051,683231..>683572) VIII 1 NT_166522.1 Remark: ORF is 3'truncated due to end of contig.; Similarity: human MTB-Zf contains two widely separated zinc-finger domains located near the N- and C-termini and the similarity is between the predicted A. niger protein fragment and the N-terminal region of MTB-Zf.; Title: similarity to zinc-finger transcription factor MTB-Zf - Homo sapiens [truncated ORF]; nucleus; See PMID 8654390; uncharacterized protein 683572 84591231 An06g02730 Aspergillus niger uncharacterized protein XP_059603815.1 683010 D 5061 CDS An08g00010 4982328 join(1216..1434,1484..2389) VIII 1 NT_166524.1 Catalytic activity: hem2 of C. glabrata converts 2 5-aminolevulinate = porphobilinogen + 2 H(2)O.; Induction: hem2 of C. glabrata requires as zinc as cofactor.; Pathway: hem2 of C. glabrata has delta-aminolevulinate dehydratase activity, which acts in the second steps in the porphyrin and heme biosynthesis.; Phenotype: C. glabrata hem2 mutants are cadmium-sensitive and partially defective in glutathione production and exhibit a complete absence of phytochelatins.; Remark: hem2 of C. glabrata is also called ALADH.; Remark: the ORF contains the sequence of A. niger EST PATENTDNA:F11250 SEQ ID NO:3773.; Title: strong similarity to porphobilinogen synthase hem2 - Candida glabrata; uncharacterized protein 2389 4982328 An08g00010 Aspergillus niger uncharacterized protein XP_001392121.1 1216 D 5061 CDS An08g00020 84591553 complement(3057..3653) VIII 1 NT_166524.1 Function: nodL on the Sym plasmid pRL1IJ of R. leguminosarum bv. viciae is a acyltransferase involved in the O-cacetylation of nodulation factors, especially in maintaining the stability of the infection thread.; Induction: nodL of R. leguminosarum bv. viciae is induced in response to flavanone molecules in a nodD-dependent way.; Phenotype: a mutation within nodL of R. leguminosarum strongly reduced nodulation of peas, Lens and Lathyrus but had little effect on nodulation of Vicia species.; Similarity: the ORF shows similarity to several acetyltransferases from different species and with various specificity.; Title: strong similarity to nodulation protein nodL - Rhizobium leguminosarum; See PMID 3132583; uncharacterized protein 3653 84591553 An08g00020 Aspergillus niger uncharacterized protein XP_059601112.1 3057 R 5061 CDS An08g00030 4982349 complement(4277..5209) VIII 1 NT_166524.1 Function: pro1 of S. macrospora encodes a C6 zinc finger transcription factor required for fruiting body development.; Similarity: the ORF shows similarity to some zinc-finger containing transcription factors from different species.; Title: similarity to transcription factor pro1 -Sordaria macrospora; uncharacterized protein 5209 4982349 An08g00030 Aspergillus niger uncharacterized protein XP_001392123.3 4277 R 5061 CDS An08g00040 84591554 join(5336..5422,5693..5812) VIII 1 NT_166524.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF; uncharacterized protein 5812 84591554 An08g00040 Aspergillus niger uncharacterized protein XP_059601113.1 5336 D 5061 CDS An08g00050 84591555 complement(join(6323..6624,6629..6701,6751..6783)) VIII 1 NT_166524.1 hypothetical protein 6783 84591555 An08g00050 Aspergillus niger hypothetical protein XP_059601114.1 6323 R 5061 CDS An08g00060 84591556 complement(join(7532..7723,7819..7875,7989..8105,8136..8178,8264..8268)) VIII 1 NT_166524.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF; uncharacterized protein 8268 84591556 An08g00060 Aspergillus niger uncharacterized protein XP_059601115.1 7532 R 5061 CDS An08g00070 4982323 join(8386..8451,8538..8567,8631..8703,8759..8830,8881..9593,9640..10411,10460..10930,11059..11288,11362..11740,11793..11964,12038..12278) VIII 1 NT_166524.1 Function: crm1 is also called exportin 1 and is the receptor for the leucine-rich nuclear export signal.; Function: crm1 of S. pombe is required for maintaining higher order chromosome structures, correct gene expression, and cell growth in the fission yeast.; Title: strong similarity to chromosome region maintenance protein 1 crm1p - Schizosaccharomyces pombe; nucleus; See PMID 10430904; uncharacterized protein 12278 4982323 An08g00070 Aspergillus niger uncharacterized protein XP_001392127.1 8386 D 5061 CDS An08g00080 4982350 join(13052..13283,13336..13631) VIII 1 NT_166524.1 Title: similarity to hypothetical protein encoded by B1D1.100 - Neurospora crassa; uncharacterized protein 13631 4982350 An08g00080 Aspergillus niger uncharacterized protein XP_001392128.1 13052 D 5061 CDS An08g00090 4982318 complement(join(14156..14857,14953..15296,15356..15894,15946..16325,16444..16479)) VIII 1 NT_166524.1 Title: weak similarity to hypothetical protein CAD70468.1 - Neurospora crassa; uncharacterized protein 16479 4982318 An08g00090 Aspergillus niger uncharacterized protein XP_059601116.1 14156 R 5061 CDS An08g00100 4982339 join(17052..17298,17359..17435) VIII 1 NT_166524.1 Remark: the hypothetical protein of S. pombe is probably conferring high osmolarity sensitivity.; Title: similarity to hypothetical protein SPAC1805.07c - Schizosaccharomyces pombe; uncharacterized protein 17435 4982339 An08g00100 Aspergillus niger uncharacterized protein XP_001392130.3 17052 D 5061 CDS An08g00110 84591557 complement(join(17463..17798,17820..17858)) VIII 1 NT_166524.1 hypothetical protein 17858 84591557 An08g00110 Aspergillus niger hypothetical protein XP_059601117.1 17463 R 5061 CDS An08g00120 84591558 complement(join(17948..18078,18173..18457,18623..18716)) VIII 1 NT_166524.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF; uncharacterized protein 18716 84591558 An08g00120 Aspergillus niger uncharacterized protein XP_059601118.1 17948 R 5061 CDS An08g00140 84591559 join(18986..19122,19386..19512) VIII 1 NT_166524.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF; uncharacterized protein 19512 84591559 An08g00140 Aspergillus niger uncharacterized protein XP_059601119.1 18986 D 5061 CDS An08g00160 84591560 complement(join(20218..20284,20368..20445,20487..20605,20914..20972,21458..21535,21770..21986,22062..22096,22172..22248,22326..22377,22455..22533)) VIII 1 NT_166524.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF; uncharacterized protein 22533 84591560 An08g00160 Aspergillus niger uncharacterized protein XP_059601120.1 20218 R 5061 CDS An08g00170 84591561 join(22606..22722,22835..23056,23150..23383) VIII 1 NT_166524.1 hypothetical protein 23383 84591561 An08g00170 Aspergillus niger hypothetical protein XP_059601121.1 22606 D 5061 CDS An08g00180 4982352 complement(join(23643..23950,24016..24134,24196..24953,25049..25417)) VIII 1 NT_166524.1 Function: cytochrome p450 proteins act on a wide range of substrates including many xenobiotics, steroids,fatty acids, vitamins and prostaglandins and catalyse reactions like hydroxylation, epoxidation, N-oxidation,sulfooxidation, N-, S- and O-dealkylations, desulfation,deamination, and reduction of azo, nitro, and N-oxide groups.; Function: the cytochrome P450 monooxygenase lovA of A. terreus is involved in the biosynthesis of polyketides,the ubiquitous products of secondary metabolism in microorganisms.; Similarity: the ORF shows similarity to several cytochrome P450 homologs from different species and with various specificity.; Title: strong similarity to cytochrome P450 monooxygenase lovA - Aspergillus terreus; See PMID 10334994; uncharacterized protein 25417 4982352 An08g00180 Aspergillus niger uncharacterized protein XP_001392136.1 23643 R 5061 CDS An08g00190 84591562 join(26493..26585,26629..26678,26747..26829,26918..26945,27005..27062) VIII 1 NT_166524.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght of only 103 amino acids.; Title: questionable ORF; uncharacterized protein 27062 84591562 An08g00190 Aspergillus niger uncharacterized protein XP_059601122.1 26493 D 5061 CDS An08g00200 84591563 join(27902..27932,28053..28219) VIII 1 NT_166524.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght of only 65 amino acids.; Title: questionable ORF; uncharacterized protein 28219 84591563 An08g00200 Aspergillus niger uncharacterized protein XP_059601123.1 27902 D 5061 CDS An08g00210 4982324 join(28975..29414,29494..29753,29824..31152,31211..31296) VIII 1 NT_166524.1 Catalytic activity: gpm1 of M. musculus catalyses Sn-glycerol 3-phosphate + acceptor = glycerone phosphate (dihydroxyacetone phosphate) + reduced acceptor.; Induction: calcium-binding enhances the activity of gpm1 from M. musculus and FAD is used as cofactor.; Pathway: gpm1 of M. musculus is involve in glycerol metabolism and is part of the mitochondrial glycerol phosphate shuttle in conjunction with an NAD-dependent cytoplasmic GPD and the anaerobic respiration machine.; Remark: a splice site was detected upstream of the START codon.; Remark: gpm1 of M. musculus is also called GPD-M,GPDH-M or GPD2.; Title: strong similarity to glycerol-3-phosphate dehydrogenase gdm1 - Mus musculus; localisation:mitochondrion; See PMID 8951039; uncharacterized protein 31296 4982324 An08g00210 Aspergillus niger uncharacterized protein XP_001392139.1 28975 D 5061 CDS An08g00220 84591564 join(32213..32319,32379..32706,32775..33062,33187..33316,33399..33542,33593..33678,33847..>33906) VIII 1 NT_166524.1 Function: amino acid permease mtr of N. crassa is required for the transport of neutral amino acids and aromatic amino acids via the N-system.; Similarity: the similarity of the ORF to amino acid permease of N. crassa is restricted to its N-terminal amino acids, ending around position 240.; Title: strong similarity to neutral amino acid permease mtr - Neurospora crassa [truncated ORF]; uncharacterized protein 33906 84591564 An08g00220 Aspergillus niger uncharacterized protein XP_059601124.1 32213 D 5061 CDS An08g00230 84591565 complement(join(34758..34792,34876..34975)) VIII 1 NT_166524.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght of only 44 amino acids.; Title: questionable ORF; uncharacterized protein 34975 84591565 An08g00230 Aspergillus niger uncharacterized protein XP_059603858.1 34758 R 5061 CDS An08g00240 84591566 complement(36516..36812) VIII 1 NT_166524.1 hypothetical protein 36812 84591566 An08g00240 Aspergillus niger hypothetical protein XP_059603859.1 36516 R 5061 CDS An08g00250 84591567 complement(join(38256..38373,38417..38571)) VIII 1 NT_166524.1 hypothetical protein 38571 84591567 An08g00250 Aspergillus niger hypothetical protein XP_059603860.1 38256 R 5061 CDS An08g00260 84591568 complement(join(38863..39176,39243..39302,39588..39609,39662..39907)) VIII 1 NT_166524.1 hypothetical protein 39907 84591568 An08g00260 Aspergillus niger hypothetical protein XP_059603861.1 38863 R 5061 CDS An08g00270 84591569 join(39992..40056,40306..40495) VIII 1 NT_166524.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght of only 84 amino acids.; Title: questionable ORF; uncharacterized protein 40495 84591569 An08g00270 Aspergillus niger uncharacterized protein XP_059603862.1 39992 D 5061 CDS An08g00280 4982338 join(40959..41031,41092..41132,41278..41404,41467..41867) VIII 1 NT_166524.1 Similarity: the ORF shows strong similarity to the unnamed ORF with cDNA FLJ14994 fis, clone Y79AA1002125 of H. sapiens.; Title: strong similarity to hypothetical protein BAB55442.1 - Homo sapiens; uncharacterized protein 41867 4982338 An08g00280 Aspergillus niger uncharacterized protein XP_059603863.1 40959 D 5061 CDS An08g00290 4982348 join(42405..42617,42708..43112,43170..43605,43659..43938,44002..44108,44174..44394) VIII 1 NT_166524.1 Function: rud3 of S. crevisiae is involved in protein translocation from the ER to golgi and complements a mutant phenotype found in sec35-2 (vesicle tethering protein) strains.; Phenotype: S. cerevisiae rud3 null mutant shows severe growth defect or inviability in combination with many ER-to-Golgi transport mutants, such as uso1-1, sec34,sec35-1, sec22-3, and bos1-1.; Remark: rud3 of S. cerevisiae is also called GRP1 or YOR216C.; Title: strong similarity to golgin-160 related protein Rud3 - Saccharomyces cerevisiae; See PMID 10562277; uncharacterized protein 44394 4982348 An08g00290 Aspergillus niger uncharacterized protein XP_059603864.1 42405 D 5061 CDS An08g00300 4982332 join(44786..44801,44866..44976,45090..45292,45385..45657) VIII 1 NT_166524.1 Catalytic activity: guanylate kinases catalyze ATP + GMP <=> ADP + GDP.; Function: guanylate kinases catalyse the reversible transfer of the terminal phosphoryl group of ATP to the acceptor molecule GMP to recycle GMP and indirectly cGMP.; Phenotype: S. cerevisiae guk1 null mutants show adenine derepression, purine excretion, and 8-azaguanine resistance.; Phenotype: allelic mutants of guk1 from S. cerevisiae (bra3) show GMP accumulation and feedback inhibition of hypoxanthine-guanine phosphoribosyltransferase (HGPRT), encoded by the HPT1 gene.; Remark: guk1 of S. cerevisiae is also called pur5 or YDR454C.; Title: strong similarity to guanylate kinase Guk1 -Saccharomyces cerevisiae; See PMID 1334480; See PMID 1967656; See PMID 2551688; uncharacterized protein 45657 4982332 An08g00300 Aspergillus niger uncharacterized protein XP_001392148.1 44786 D 5061 CDS An08g00310 4982341 complement(join(46165..46503,46562..46775,46840..46977,47032..47113,47173..47301,47381..47519)) VIII 1 NT_166524.1 Function: aspD of A. nidulans belongs to the highly conserved septin family of presumably cytoskeletal proteins involved in cytokinesis and morphogenesis.; Remark: all known A. nidulans septins, including all asp products except that of aspD, contain predicted coiled-coil domains at or near the carboxyl termini.; Similarity: the ORF shows similarity to cell division control proteins from different species.; Title: strong similarity to septin aspD -Aspergillus nidulans; See PMID 10481176; See PMID 11181167; See PMID 11238387; uncharacterized protein 47519 4982341 An08g00310 Aspergillus niger uncharacterized protein XP_001392149.1 46165 R 5061 CDS An08g00320 84591570 join(47617..47652,47748..47831) VIII 1 NT_166524.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght of only 39 amino acids.; Title: questionable ORF; uncharacterized protein 47831 84591570 An08g00320 Aspergillus niger uncharacterized protein XP_059603865.1 47617 D 5061 CDS An08g00330 84591571 join(48080..48413,48487..48524) VIII 1 NT_166524.1 Function: ribosomal protein L32p is part of the 50 S ribosomal subunit of pro- and eukaryotes, the S. cerevisiae protein binds to and regulates the splicing and the translation of the transcript of its own gene.; Remark: YmL32 of S. cerevisiae is also called MRPL32, YCR003W, YCR041 or YCR3W.; Title: strong similarity to mitochondrial ribosomal protein of the large subunit Yml32 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8366109; See PMID 9121443; See PMID 3316213; mitochondrial 54S ribosomal protein bL32m 48524 84591571 An08g00330 Aspergillus niger mitochondrial 54S ribosomal protein bL32m XP_059603866.1 48080 D 5061 CDS An08g00340 4982316 join(49042..49044,49116..49152,49211..49471,49519..49688,49753..49846,49920..50106,50154..50337) VIII 1 NT_166524.1 Function: rec14 of S. pombe is essential for meiotic recombination.; Title: strong similarity to meiotic recombination protein rec14p - Schizosaccharomyces pombe; See PMID 9752725; uncharacterized protein 50337 4982316 An08g00340 Aspergillus niger uncharacterized protein XP_059603867.1 49042 D 5061 CDS An08g00350 4982354 complement(join(50577..51121,51180..51411)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein SPCC188.04c - Schizosaccharomyces pombe; uncharacterized protein 51411 4982354 An08g00350 Aspergillus niger uncharacterized protein XP_001392153.1 50577 R 5061 CDS An08g00360 4982345 join(51843..51945,51977..53200,53259..53952,54003..55065) VIII 1 NT_166524.1 Complex: transcription initiation factor RRN6 of S. cerevisiae forms a heterotrimeric complex with RRN7 and a 66kD protein, which may further dimerize to form a hexamer.; Function: the heterotrimeric complex is essential for the initiation of rDNA transcription by RNA polymerase I. binding to the DNA template is dependent on the initial binding of other factors.; Title: similarity to transcription initiation factor Rrn6 - Saccharomyces cerevisiae; See PMID 7958901; uncharacterized protein 55065 4982345 An08g00360 Aspergillus niger uncharacterized protein XP_059603868.1 51843 D 5061 CDS An08g00370 4982321 join(55578..55665,55804..55955) VIII 1 NT_166524.1 Remark: HAH1 is a ubiquitously expressed protein,which plays an essential role in antioxidant defense and copper homeostasis in humans.; Title: strong similarity to copper transport protein HAH1 - Homo sapiens; See PMID 9083055; uncharacterized protein 55955 4982321 An08g00370 Aspergillus niger uncharacterized protein XP_001392155.1 55578 D 5061 CDS An08g00380 4982317 complement(join(56498..56624,56707..58079,58172..58903,58985..59275,59339..59458,59511..59645)) VIII 1 NT_166524.1 Similarity: only N-terminal 250 aa show similarity to An01g10240.; Title: similarity to hypothetical protein CAD70412.1 - Neurospora crassa; uncharacterized protein 59645 4982317 An08g00380 Aspergillus niger uncharacterized protein XP_059603869.1 56498 R 5061 CDS An08g00390 4982333 60523..60837 VIII 1 NT_166524.1 Title: similarity to hypothetical protein SPAC806.05 - Schizosaccharomyces pombe; uncharacterized protein 60837 4982333 An08g00390 Aspergillus niger uncharacterized protein XP_001392157.3 60523 D 5061 CDS An08g00400 4982351 join(61583..62830,62886..63250,63302..63914) VIII 1 NT_166524.1 Title: strong similarity to hypothetical zinc-finger protein - Schizosaccharomyces pombe; uncharacterized protein 63914 4982351 An08g00400 Aspergillus niger uncharacterized protein XP_001392158.1 61583 D 5061 CDS An08g00410 4982344 65026..68001 VIII 1 NT_166524.1 Title: similarity to hypothetical protein BAA92131.1 - Homo sapiens; uncharacterized protein 68001 4982344 An08g00410 Aspergillus niger uncharacterized protein XP_001392159.1 65026 D 5061 CDS An08g00420 4982356 join(68554..69342,69427..69690,69763..69924,70002..70025) VIII 1 NT_166524.1 Remark: ciao-1 is a Wilms' tumour (WT1) binding protein. Products of the invention can be used for identifying agents which modulate the expression or activity of the Wilm's tumour suppressor gene, WT1. The products can be used for treating e. g. tumours,endometriosis, ependymonas, for transplantation of organs,for treating degenerative disorders of lung tissue caused by e. g. toxic injuries, as well as inflammatory and degenerative processes induced by viral infections.; Title: strong similarity to ciao-1 protein s from patent WO9813494-A2 - Homo sapiens; uncharacterized protein 70025 4982356 An08g00420 Aspergillus niger uncharacterized protein XP_059603870.1 68554 D 5061 CDS An08g00430 4982357 complement(join(70243..71589,71659..72019,72087..72217)) VIII 1 NT_166524.1 Catalytic activity: preferential release of a C-terminal arginine or lysine residue.; Function: the S. cerevisiae homolog Kex1p is a type I transmembrane carboxypeptidase involved in precursor processing within the yeast secretory pathway.; Golgi; Remark: S. cerevisiae Kex1p has a broad specificity with optimum pH 4. 5-6. 0.; Repression: Kex1p is inhibited by the action of diisopropyl fluorophosphate, and sensitive to thiol-blocking reagents.; Title: strong similarity to precursor of carboxypeptidase Kex1 - Saccharomyces cerevisiae; uncharacterized protein 72217 4982357 An08g00430 Aspergillus niger uncharacterized protein XP_001392161.3 70243 R 5061 CDS An08g00440 4982358 complement(join(73244..73300,73376..73494,73552..73662,73725..73742,73842..74175)) VIII 1 NT_166524.1 Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to hypothetical protein YOR021c - Saccharomyces cerevisiae; uncharacterized protein 74175 4982358 An08g00440 Aspergillus niger uncharacterized protein XP_001392162.1 73244 R 5061 CDS An08g00450 4982359 join(75714..75749,75828..75911,75980..76354) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein SPAC10F6.16 - Schizosaccharomyces pombe; uncharacterized protein 76354 4982359 An08g00450 Aspergillus niger uncharacterized protein XP_001392163.1 75714 D 5061 CDS An08g00460 84591572 complement(join(77071..77193,77224..77301,77328..77365,77564..77654)) VIII 1 NT_166524.1 hypothetical protein 77654 84591572 An08g00460 Aspergillus niger hypothetical protein XP_059603871.1 77071 R 5061 CDS An08g00470 4982361 complement(join(78163..78966,79034..79555)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein SPAC23C11.01 - Schizosaccharomyces pombe; uncharacterized protein 79555 4982361 An08g00470 Aspergillus niger uncharacterized protein XP_001392165.1 78163 R 5061 CDS An08g00480 4982362 join(80859..80917,81008..82040) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein BAB23171.1 - Mus musculus; uncharacterized protein 82040 4982362 An08g00480 Aspergillus niger uncharacterized protein XP_001392166.3 80859 D 5061 CDS An08g00490 4982363 complement(join(82282..82585,82660..82897,82963..83494)) VIII 1 NT_166524.1 Catalytic activity: D-glucono-1,5-lactone + H(2)O <=> D-gluconate.; Remark: Acts on a wide range of hexono-1,5-lactones.; Remark: Also involved in ascorbate and aldarate metabolism, caprolactam degradation.; Title: strong similarity to lactonohydrolase -Fusarium oxysporum; See PMID 9788992; uncharacterized protein 83494 4982363 An08g00490 Aspergillus niger uncharacterized protein XP_001392167.3 82282 R 5061 CDS An08g00500 4982364 complement(join(83742..84011,84057..84262,84351..84888)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein CAD70990.1 - Neurospora crassa; uncharacterized protein 84888 4982364 An08g00500 Aspergillus niger uncharacterized protein XP_059603872.1 83742 R 5061 CDS An08g00510 4982365 join(85164..85300,85421..87263) VIII 1 NT_166524.1 Title: strong similarity to cytosolic methionine--tRNA ligase Mes1 - Saccharomyces cerevisiae; uncharacterized protein 87263 4982365 An08g00510 Aspergillus niger uncharacterized protein XP_001392169.1 85164 D 5061 CDS An08g00520 4982366 complement(join(88121..88936,89005..89268)) VIII 1 NT_166524.1 Function: sonA protein of A. nidulans is involved in the nuclear localization of the NIMXCDC2/ NIMECyclin B complex.; Localization: SONA-HA staining pattern is similar to the nuclear pore-like staining pattern seen for GLE2.; Remark: a splice site was detected upstream of the START codon.; Remark: mutations in sonA were identified as allele-specific suppressors of serine/threonine protein kinase nimA1.; Similarity: the predicted A. niger protein shows strong similarity to the sonA protein of A. nidulans and homologues Rae1/Gle2 of diverse eucaryotic organisms.; Title: strong similarity to protein sonA -Aspergillus nidulans; See PMID 9647650; uncharacterized protein 89268 4982366 An08g00520 Aspergillus niger uncharacterized protein XP_001392170.1 88121 R 5061 CDS An08g00530 84591573 join(90082..90137,90184..90286,90371..90643) VIII 1 NT_166524.1 hypothetical protein 90643 84591573 An08g00530 Aspergillus niger hypothetical protein XP_059603873.1 90082 D 5061 CDS An08g00540 4982368 join(91641..91652,91961..91993,92167..92352,92446..92495,92553..92736,92812..92964) VIII 1 NT_166524.1 Title: strong similarity to EST SEQ ID NO:4140 from patent WO200056762-A2 - Aspergillus niger; uncharacterized protein 92964 4982368 An08g00540 Aspergillus niger uncharacterized protein XP_059603874.1 91641 D 5061 CDS An08g00550 4982369 complement(join(93685..94718,94845..95350,95645..97500)) VIII 1 NT_166524.1 Protein sequence is in conflict with the conceptual translation; Function: Essential for mitotic growth. Mediates organelle inheritance.; Similarity: S. cerevisiae MDM1 protein has low similarity to vimentins and other intermediate filaments.; Title: strong similarity to protein Mdm1 -Saccharomyces cerevisiae [putative sequencing error]; putative sequencing error; See PMID 1378448; uncharacterized protein 97500 4982369 An08g00550 Aspergillus niger uncharacterized protein XP_059603875.1 93685 R 5061 CDS An08g00560 4982370 join(97979..98222,98309..98348,98403..98419,98588..99014,99191..99266) VIII 1 NT_166524.1 Catalytic activity: phosphatidyl-N-methylethanolamine N-methyltransferases catalyze the conversion of S-adenosyl-L-methionine + phosphatidyl-ethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-n-methylethanolamine.; Function: phosphatidyl-N-methylethanolamine N-methyltransferase OPI3 of S. cerevisiae catalyzes the Second and third steps of methylation pathway for phosphatidylcholine biosynthesis.; Title: strong similarity to phosphatidyl-N-methylethanolamine N-methyltransferase Opi3 - Saccharomyces cerevisiae; See PMID 8431960; See PMID 11078727; uncharacterized protein 99266 4982370 An08g00560 Aspergillus niger uncharacterized protein XP_001392174.3 97979 D 5061 CDS An08g00570 4982371 complement(join(100021..101288,101359..101512,101628..101888)) VIII 1 NT_166524.1 Title: weak similarity to dentin matrix acidic phosphoprotein 1 DMP1 - Homo sapiens; uncharacterized protein 101888 4982371 An08g00570 Aspergillus niger uncharacterized protein XP_059603876.1 100021 R 5061 CDS An08g00580 4982372 complement(join(102485..104256,104317..104430,104531..106145,106351..106641)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein CG14966 -Drosophila melanogaster; uncharacterized protein 106641 4982372 An08g00580 Aspergillus niger uncharacterized protein XP_059603877.1 102485 R 5061 CDS An08g00590 4982373 join(109248..111021,111077..112005) VIII 1 NT_166524.1 Similarity: aminoacids 523 to 641 show similarity to N-terminal third of Rv3312c of M. tuberculosis.; Title: weak similarity to hypothetical protein Rv3312c - Mycobacterium tuberculosis; uncharacterized protein 112005 4982373 An08g00590 Aspergillus niger uncharacterized protein XP_001392177.1 109248 D 5061 CDS An08g00600 4982374 join(112958..113032,113112..113493,113588..113889) VIII 1 NT_166524.1 Function: glutaredoxins and thioredoxins are ubiquitous small heat-stable oxidoreductases that have proposed functions in many cellular processes, including deoxyribonucleotide synthesis, repair of oxidatively damaged proteins, protein folding and sulphur metabolism.; Similarity: shows similarity to several glutaredoxin and glutaredoxin-like proteins.; Title: similarity to glutaredoxin - Oryza sativa; See PMID 8430514; See PMID 11169096; uncharacterized protein 113889 4982374 An08g00600 Aspergillus niger uncharacterized protein XP_001392178.1 112958 D 5061 CDS An08g00610 4982375 join(114632..114677,114958..115005,115164..115419,115599..115776,115857..115907) VIII 1 NT_166524.1 Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L9.b - Saccharomyces cerevisiae; cytoplasm; See PMID 9559554; 60S ribosomal protein uL6 115907 4982375 An08g00610 Aspergillus niger 60S ribosomal protein uL6 XP_001392179.1 114632 D 5061 CDS An08g00620 4982376 join(116566..116870,116958..117774,117841..118599) VIII 1 NT_166524.1 Title: similarity to hypothetical protein SPCC1450.16c - Schizosaccharomyces pombe; uncharacterized protein 118599 4982376 An08g00620 Aspergillus niger uncharacterized protein XP_059603878.1 116566 D 5061 CDS An08g00630 4982377 complement(join(120023..120060,120125..121685,121858..121935)) VIII 1 NT_166524.1 Function: HNM1 of S. cerevisiae is the yeast cholin transporter.; Similarity: shows similarity to several putative and known aminoacid, GABA, and cholin transporter.; Title: similarity to choline permease Hnm1 -Saccharomyces cerevisiae; plasma membrane; See PMID 8264542; See PMID 7520996; uncharacterized protein 121935 4982377 An08g00630 Aspergillus niger uncharacterized protein XP_001392181.3 120023 R 5061 CDS An08g00640 4982378 complement(join(122694..122821,122876..124903,124990..125002)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein YGR266w -Saccharomyces cerevisiae; uncharacterized protein 125002 4982378 An08g00640 Aspergillus niger uncharacterized protein XP_001392182.1 122694 R 5061 CDS An08g00650 84591574 join(126479..126522,126602..126679,126718..126751,126881..127041,127085..127109) VIII 1 NT_166524.1 hypothetical protein 127109 84591574 An08g00650 Aspergillus niger hypothetical protein XP_059603879.1 126479 D 5061 CDS An08g00660 4982380 complement(127423..129012) VIII 1 NT_166524.1 hypothetical protein 129012 4982380 An08g00660 Aspergillus niger hypothetical protein XP_001392184.1 127423 R 5061 CDS An08g00670 4982381 complement(join(130017..130278,130337..130511,130584..130917,130973..131076,131137..132007)) VIII 1 NT_166524.1 Similarity: shows only similarity to other protein in the C-terminal region containing the rhomboid family domain.; Title: similarity to hypothetical membrane protein YGR101w - Saccharomyces cerevisiae; uncharacterized protein 132007 4982381 An08g00670 Aspergillus niger uncharacterized protein XP_001392185.1 130017 R 5061 CDS An08g00680 4982382 join(132506..132880,133058..133261) VIII 1 NT_166524.1 hypothetical protein 133261 4982382 An08g00680 Aspergillus niger hypothetical protein XP_001392186.3 132506 D 5061 CDS An08g00690 4982383 complement(join(133629..134130,134196..134310,134375..134682,134960..134982)) VIII 1 NT_166524.1 Function: Mob1p of S. cerevisiae is required for completion of mitosis and maintenance of ploidy.; Title: similarity to completion of mitosis and maintenance of ploidy protein Mob1 - Saccharomyces cerevisiae; See PMID 9436989; uncharacterized protein 134982 4982383 An08g00690 Aspergillus niger uncharacterized protein XP_001392187.1 133629 R 5061 CDS An08g00700 4982384 join(135542..135750,135803..135977,136037..137038) VIII 1 NT_166524.1 Title: similarity to hydrophilic proteasome interacting protein Leo1 - Saccharomyces cerevisiae; uncharacterized protein 137038 4982384 An08g00700 Aspergillus niger uncharacterized protein XP_001392188.1 135542 D 5061 CDS An08g00710 4982385 complement(join(137452..138572,138640..138766)) VIII 1 NT_166524.1 Similarity: the predicted ORF is only similar to a small region of the N-terminus of A. parasiticus alfR.; Title: weak similarity to aflatoxin biosynthesis regulatory protein aflR - Aspergillus parasiticus; uncharacterized protein 138766 4982385 An08g00710 Aspergillus niger uncharacterized protein XP_001392189.3 137452 R 5061 CDS An08g00720 4982386 139060..141426 VIII 1 NT_166524.1 Remark: functional annotation of ERB1 was transferred from the SGD database.; Remark: the systematic genename of ERB1 is YMR049c.; Title: strong similarity to conserved eukaryotic protein involved in ribosome biogenesis Erb1 -Saccharomyces cerevisiae; uncharacterized protein 141426 4982386 An08g00720 Aspergillus niger uncharacterized protein XP_001392190.1 139060 D 5061 CDS An08g00730 4982387 complement(join(141837..143756,143849..144091,144156..144203)) VIII 1 NT_166524.1 Complex: the native rat TER ATPase has been characterized as a hexamer of six 100-kD subunits by gel filtration.; Function: AAA proteins act in a variety of cellular functions, including cell-cycle regulation, protein degradation, organelle biogenesis and vesicle-mediated protein transport.; Function: the rat protein has been isolated as an ATPase with a monomer molecular weight of 100 kD by SDS-PAGE from TER and designated as TER ATPase.; Function: the transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough,part-smooth transitional elements of the endoplasmic reticulum (TER).; Function: vesicle budding from the TER is an ATP-dependent process both in vivo and in vitro.; Similarity: shows strong similarity to several proteins of the AAA family of ATPases.; Title: similarity to transitional endoplasmic reticulum ATPase - Rattus norvegicus; See PMID 7806566; See PMID 9695811; See PMID 10893253; uncharacterized protein 144203 4982387 An08g00730 Aspergillus niger uncharacterized protein XP_001392191.1 141837 R 5061 CDS An08g00740 4982388 join(144506..144549,144675..145332) VIII 1 NT_166524.1 Function: deletion mutants of VPS20 stabilize Ste6 and show a 'class E vps phenotype'; Ste6, a member of the ABC-transporter family, is transported to the yeast vacuole for degradation.; Function: in deletion mutants of VPS20 maturation of the vacuolar hydrolase carboxypeptidase Y is affected and the endocytic tracer FM4-64 and Ste6 accumulate in a dot or ring-like structure next to the vacuole.; Remark: the systematic name of VPS20 is YMR077c.; Title: strong similarity to vacuolar protein sorting-associated protein Vps20 - Saccharomyces cerevisiae; See PMID 11251082; uncharacterized protein 145332 4982388 An08g00740 Aspergillus niger uncharacterized protein XP_059603880.1 144506 D 5061 CDS An08g00750 4982389 complement(join(145632..146043,146220..146331,146401..146542)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical conserved protein SPBP35G2.02 - Schizosaccharomyces pombe; uncharacterized protein 146542 4982389 An08g00750 Aspergillus niger uncharacterized protein XP_001392193.1 145632 R 5061 CDS An08g00760 4982390 complement(join(147014..147145,147210..148868,148926..149150)) VIII 1 NT_166524.1 Function: Prp22 of S. cerevisiae was shown to be involved in the release of spliced mRNAs from the spliceosomes.; Similarity: matches only to the C-terminal two thirds of Prp22p of S. cerevisiae; S. cerevisiae Prp22p is about 450 aminoacids longer at N-terminus. .; Similarity: shows strong similarity to several putative eukaryotic RNA helicases.; Title: similarity to RNA helicase Prp22 -Saccharomyces cerevisiae; nucleus; See PMID 10684925; See PMID 11230534; uncharacterized protein 149150 4982390 An08g00760 Aspergillus niger uncharacterized protein XP_001392194.1 147014 R 5061 CDS An08g00770 4982391 join(149594..149614,149674..149974,150034..150258,150316..150585,150655..151016) VIII 1 NT_166524.1 Title: similarity to hypothetical protein SPBC16E9.02c - Schizosaccharomyces pombe; uncharacterized protein 151016 4982391 An08g00770 Aspergillus niger uncharacterized protein XP_001392195.1 149594 D 5061 CDS An08g00780 4982392 complement(join(151389..151496,151548..151625,151913..151990)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein AT4g09550 - Arabidopsis thaliana; uncharacterized protein 151990 4982392 An08g00780 Aspergillus niger uncharacterized protein XP_059603881.1 151389 R 5061 CDS An08g00790 4982393 join(152529..153003,153036..153322) VIII 1 NT_166524.1 Similarity: all homologs are longer at C-terminus.; Similarity: shows similarity to several putative acetyltransferases.; Title: similarity to hypothetical acetyltransferase F21B7.10 - Arabidopsis thaliana; uncharacterized protein 153322 4982393 An08g00790 Aspergillus niger uncharacterized protein XP_001392197.3 152529 D 5061 CDS An08g00800 4982394 153687..156512 VIII 1 NT_166524.1 Similarity: C-terminal half shows similarity to AF-4 protein of M. musculus.; Similarity: N-terminal half shows similarity to Axl2p (YIL140W) of S. cerevisiae.; Title: similarity to plasma membrane glycoprotein Axl2 - Saccharomyces cerevisiae; See PMID 8846915; See PMID 9732282; See PMID 10366591; uncharacterized protein 156512 4982394 An08g00800 Aspergillus niger uncharacterized protein XP_001392198.1 153687 D 5061 CDS An08g00810 4982395 join(157028..157483,157601..157677,157803..158157,158247..158693) VIII 1 NT_166524.1 Similarity: shows similarity to several resistance proteins.; Title: similarity to tetracyclin resistance protein TetH - Pasteurella multocida; See PMID 8109938; uncharacterized protein 158693 4982395 An08g00810 Aspergillus niger uncharacterized protein XP_059603882.1 157028 D 5061 CDS An08g00820 84591575 complement(join(159239..159379,159501..159583,159629..159722,159814..159845,160112..160222,160403..160436)) VIII 1 NT_166524.1 hypothetical protein 160436 84591575 An08g00820 Aspergillus niger hypothetical protein XP_059603883.1 159239 R 5061 CDS An08g00830 4982397 join(160950..160985,161367..161685,161790..161863,161932..162016,162084..162290,162356..162535,162681..163054) VIII 1 NT_166524.1 Function: Ptc2p of S. cerevisiae downregulates the UPR (unfolded-protein response) by dephosphorylating Ire1p and reveal a novel mechanism of regulation in the UPR pathway upstream of the HAC1 mRNA splicing event.; Function: Ptc2p of S. cerevisiae is involved in the DNA checkpoint pathways.; Pathway: unfolded protein response pathway; cells respond to the accumulation of unfolded proteins in the endoplasmic reticulum (ER) by increasing the transcription of the genes encoding ER-resident chaperone proteins.; Similarity: all homologs are 36 aminoacids longer at N-terminus.; Title: strong similarity to protein phosphatase type 2C Ptc2 - Saccharomyces cerevisiae; See PMID 9528768; See PMID 10440230; See PMID 10747050; uncharacterized protein 163054 4982397 An08g00830 Aspergillus niger uncharacterized protein XP_059603884.1 160950 D 5061 CDS An08g00840 4982398 join(164877..165406,165462..165812,165867..166314) VIII 1 NT_166524.1 Catalytic activity: choline-phosphate cytidylyltransferase catalyzes the conversion of CTP + choline phosphate = pyrophosphate + CDP choline.; Pathway: choline-phosphate cytidylyltransferase is involved in phospholipid biosynthesis.; Title: similarity to choline-phosphate cytidylyltransferase Pct1 - Saccharomyces cerevisiae; See PMID 11078727; See PMID 2826147; uncharacterized protein 166314 4982398 An08g00840 Aspergillus niger uncharacterized protein XP_001392202.3 164877 D 5061 CDS An08g00850 4982399 complement(join(166977..167689,167850..168189)) VIII 1 NT_166524.1 Title: weak similarity to hypothetical protein encoded by An13g00450 - Aspergillus niger; uncharacterized protein 168189 4982399 An08g00850 Aspergillus niger uncharacterized protein XP_059603885.1 166977 R 5061 CDS An08g00860 4982400 complement(join(169230..169540,169625..170276,170447..170818)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical membrane protein YMR253c - Saccharomyces cerevisiae; uncharacterized protein 170818 4982400 An08g00860 Aspergillus niger uncharacterized protein XP_059603886.1 169230 R 5061 CDS An08g00870 4982401 complement(join(171680..172598,172655..173232,173288..173484,173537..173904,173957..174060)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein 1A9.230 - Neurospora crassa; uncharacterized protein 174060 4982401 An08g00870 Aspergillus niger uncharacterized protein XP_001392205.1 171680 R 5061 CDS An08g00880 4982402 join(174354..174458,174528..175240,175326..175544,175713..175747,175872..175927) VIII 1 NT_166524.1 Function: the presence of homologous, and sometimes identical, proteins in contrasting functional contexts suggests that the large multisubunit complexes of the 26S proteasome, eIF3 and TFIIH perform overlapping cellular roles.; Similarity: p40 and p47 subunits of eIF3 are shown to be homologues of the proteasome subunit Mov34, and transcriptional regulators JAB1/pad1.; Similarity: shows also strong similarity to probable 26s proteasome regulatory subunits.; Title: strong similarity to hypothetical branched-chain alpha-ketoacid dehydrogenase E1 beta subunit - Homo sapiens; See PMID 9341143; See PMID 9605331; uncharacterized protein 175927 4982402 An08g00880 Aspergillus niger uncharacterized protein XP_059603887.1 174354 D 5061 CDS An08g00890 4982403 complement(join(176505..176953,177031..177091)) VIII 1 NT_166524.1 Complex: S. cerevisiae TFIID is composed of TBP, the TATA box binding protein, and 14 distinct TBP-associated factors (TAFs), which range in size from 17 to 150 kDa.; Function: in eukaryotic cells the TATA-binding protein (TBP) associates with other proteins known as TBP-associated factors (TAFs) to form multisubunit transcription factors important for gene expression by all three nuclear RNA polymerases.; Remark: the alternate genename of S. cerevisiae TAF19 is FUN81.; Title: strong similarity to subunit of transcription initation factor TFIID Taf19 - Saccharomyces cerevisiae; nucleus; See PMID 8962109; See PMID 10721692; See PMID 10864925; uncharacterized protein 177091 4982403 An08g00890 Aspergillus niger uncharacterized protein XP_001392207.3 176505 R 5061 CDS An08g00900 4982404 join(177712..177830,177918..>178100) VIII 1 NT_166524.1 Remark: putative sequencing error, 1 bp too much.; Title: strong similarity to hypothetical protein BAB22431.1 - Mus musculus [putative frameshift]; putative frameshift; uncharacterized protein 178100 4982404 An08g00900 Aspergillus niger uncharacterized protein XP_059603888.1 177712 D 5061 CDS An08g00910 4982405 complement(178358..180547) VIII 1 NT_166524.1 Title: similarity to hypothetical membrane-associated salt-inducible protein OSJNBa0055P24.12 - Oryza sativa; uncharacterized protein 180547 4982405 An08g00910 Aspergillus niger uncharacterized protein XP_001392209.1 178358 R 5061 CDS An08g00920 4982406 181172..181783 VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein 1A9.290 - Neurospora crassa; uncharacterized protein 181783 4982406 An08g00920 Aspergillus niger uncharacterized protein XP_001392210.1 181172 D 5061 CDS An08g00930 4982407 complement(join(182103..182787,182854..182989,183043..183127)) VIII 1 NT_166524.1 Similarity: the predicted ORF may be N-terminally too short.; Title: weak similarity to hypothetical protein CAB88521.3 - Neurospora crassa; uncharacterized protein 183127 4982407 An08g00930 Aspergillus niger uncharacterized protein XP_059603889.1 182103 R 5061 CDS An08g00940 4982408 join(184101..184987,185049..185189,185248..186655) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein 1A9.260 - Neurospora crassa; uncharacterized protein 186655 4982408 An08g00940 Aspergillus niger uncharacterized protein XP_059603890.1 184101 D 5061 CDS An08g00950 4982409 complement(join(187333..187692,187798..188013)) VIII 1 NT_166524.1 Complex: YmL8 of S. cerevisiae is a mitochondrial ribosomal protein of the large subunit.; Remark: YmL8 of S. cerevisiae is also called MRPL8,L17, YJL063C, J1125, or HRD238.; Title: strong similarity to mitochondrial ribosomal protein of the large subunit Yml8 - Saccharomyces cerevisiae; localisation:mitochondrion; mitochondrial 54S ribosomal protein bL17m 188013 4982409 An08g00950 Aspergillus niger mitochondrial 54S ribosomal protein bL17m XP_001392213.1 187333 R 5061 CDS An08g00960 4982410 complement(join(188796..189249,189570..190351)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein AD11338.1 - Neurospora crassa; uncharacterized protein 190351 4982410 An08g00960 Aspergillus niger uncharacterized protein XP_001392214.3 188796 R 5061 CDS An08g00970 4982411 join(191004..191262,191456..191634) VIII 1 NT_166524.1 Complex: ribosomal protein S12 is one of the proteins from the small ribosomal subunit.; Gene-ID: rps28; Remark: a splice site was detected upstream of the START codon.; cytoplasm; 40S ribosomal protein uS12 191634 rps28 4982411 rps28 Aspergillus niger 40S ribosomal protein uS12 XP_001392215.1 191004 D 5061 CDS An08g00980 4982412 complement(join(192187..192259,192315..193134,193235..193530,193597..193694)) VIII 1 NT_166524.1 Complex: the guanine nucleotide exchange factor for eIF-2 in S. cerevisiae is a complex of five different subunits; alpha (GCD3), beta (GCD7), gamma (GCD1), delta (GCD2) and epsilon (GCD6).; Function: Gcd7p of S. cerevisiae is a subunit of the guanine nucleotide exchange factor for eIF-2.; Function: Gcd7p of S. cerevisiae is required to repress GCN4 translation under nonstarvation conditions.; Title: strong similarity to translation initiation factor eIF2B guanine nucleotide exchange factor 43 kDa subunit Gcd7 - Saccharomyces cerevisiae; See PMID 8506384; See PMID 9472020; uncharacterized protein 193694 4982412 An08g00980 Aspergillus niger uncharacterized protein XP_059603891.1 192187 R 5061 CDS An08g00990 4982413 join(194651..196049,196113..196255) VIII 1 NT_166524.1 Function: NEM1 of S. cerevisiae required for correct nuclear morphology.; Remark: YHR004C is an alternativ name for NEM1.; Remark: a splice site was detected upstream of the START codon.; Remark: the region of similarity of the ORF encoded protein to NEM1 of S. cerevisiae is restricted to the C-terminus.; Similarity: C-terminal 200 residues of the ORF encoded protein and of NEM1 show similarity to the C-termini of YLL010c, YLR019w, YPL063w, hypothetical C. elegans and S. pombe and human proteins; Title: similarity to Nem1 - Saccharomyces cerevisiae; See PMID 9822591; uncharacterized protein 196255 4982413 An08g00990 Aspergillus niger uncharacterized protein XP_001392217.1 194651 D 5061 CDS An08g01000 4982414 complement(join(197593..198664,198750..198838)) VIII 1 NT_166524.1 Catalytic activity: aspC of M. thermoformicicum catalyzes the reaktion of L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.; Remark: aspartate transaminase also acts on L-tyrosine, L-phenylalanine and L-tryptophan; this activity can be formed from EC 2. 6. 1. 57 by controlled proteolysis.; Remark: the ORF encoded protein also shows similarity to other transaminases.; Title: strong similarity to aspartate transaminase aspC - Methanobacterium thermoformicicum; See PMID 8206881; uncharacterized protein 198838 4982414 An08g01000 Aspergillus niger uncharacterized protein XP_001392218.1 197593 R 5061 CDS An08g01010 84591576 complement(join(199715..199798,199909..200184)) VIII 1 NT_166524.1 hypothetical protein 200184 84591576 An08g01010 Aspergillus niger hypothetical protein XP_059601125.1 199715 R 5061 CDS An08g01020 4982416 join(200357..200397,200463..201123) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein YJL055w - Saccharomyces cerevisiae; uncharacterized protein 201123 4982416 An08g01020 Aspergillus niger uncharacterized protein XP_001392220.1 200357 D 5061 CDS An08g01030 4982417 join(201557..201613,201773..202186,202257..202373) VIII 1 NT_166524.1 Complex: in S. cerevisiae Vps35p and Vps29p interact and form part of a multimeric membrane-associated complex,designated as the retromer complex, that also contains Vps26p, Vps17p, and Vps5p.; Function: Vps29p of S. cerevisiae is a component of the sorting machinery required for the endosome-to-Golgi retrieval of the vacuolar protein sorting receptor Vps10p.; Function: experiments with S. cerevisiae suggest a model in which Vps35p/Vps29p/Vps26p function to select cargo for retrieval, and Vps5p/Vps17p assemble onto the membrane to promote vesicle formation.; Golgi; Title: strong similarity to vacuolar protein sorting protein Vps29 - Saccharomyces cerevisiae; See PMID 9700157; uncharacterized protein 202373 4982417 An08g01030 Aspergillus niger uncharacterized protein XP_059601126.1 201557 D 5061 CDS An08g01040 4982418 join(203168..203236,203376..203632,203694..203781,203843..203998) VIII 1 NT_166524.1 Function: in D. melanogaster Pabp2 stimulates poly(A) polymerase and is able to control poly(A) tail length.; Title: strong similarity to poly(A)-binding protein II Pabp2 - Drosophila melanogaster; nucleus; See PMID 10481015; uncharacterized protein 203998 4982418 An08g01040 Aspergillus niger uncharacterized protein XP_001392222.1 203168 D 5061 CDS An08g01050 84591577 complement(join(205221..205261,205428..205465,205579..205727,205847..205955,205986..206014)) VIII 1 NT_166524.1 Title: weak similarity to hypothetical protein P0504H10 - Oryza sativa; uncharacterized protein 206014 84591577 An08g01050 Aspergillus niger uncharacterized protein XP_059601127.1 205221 R 5061 CDS An08g01060 4982420 join(206321..206340,206451..206473,206558..206596,206657..206762,206822..206955,207027..208242,208301..208594,208643..208780,208826..209221,209277..209376) VIII 1 NT_166524.1 Function: S. pombe pub1 either directly or indirectly regulates membrane transport processes and membrane permease turnover.; Function: in S. pombe the E3 ubiquitin protein ligase Pub1 ubiquinates the mitotic activating tyrosine phosphatase cdc25, thereby regulating cdc25 levels and activity.; Title: strong similarity to ubiquitin protein ligase ub1p - Schizosaccharomyces pombe; See PMID 8635463; See PMID 9197411; uncharacterized protein 209376 4982420 An08g01060 Aspergillus niger uncharacterized protein XP_001392224.1 206321 D 5061 CDS An08g01070 4982421 complement(join(210533..210807,211074..211188,211285..212397,212448..212828)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein BAC67939.1 - Streptomyces avermitilis; uncharacterized protein 212828 4982421 An08g01070 Aspergillus niger uncharacterized protein XP_059601128.1 210533 R 5061 CDS An08g01080 4982422 complement(join(214475..215171,215245..215603)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein F28J15.5 -Arabidopsis thaliana; uncharacterized protein 215603 4982422 An08g01080 Aspergillus niger uncharacterized protein XP_059601129.1 214475 R 5061 CDS An08g01090 4982423 complement(216004..218103) VIII 1 NT_166524.1 Complex: in S. cerevisiae AHC1 is part of the 0. 8-MDa ADA complex which also contains the adapter proteins Ada2, Ada3, and Gcn5.; Function: S. cerevisiae AHC1 in high copy numbers suppresses the cold sensitivity caused by particular mutations in HTA1 which encodes histone H2A.; Remark: YOR023c is the systematic name for AHC1.; Title: similarity to Ada Histone acetyltransferase complex component Ahc1 - Saccharomyces cerevisiae; nucleus; See PMID 10490601; uncharacterized protein 218103 4982423 An08g01090 Aspergillus niger uncharacterized protein XP_001392227.3 216004 R 5061 CDS An08g01100 4982424 221698..222858 VIII 1 NT_166524.1 Catalytic activity: glucan 1,3-beta-glucosidases catalyse the successive hydrolysis of beta-D-glucose units from the non-reducing ends of 1,3-beta-D-glucans, releasing alpha-glucose.; Function: disruption of K. lactis KlEXG1 did not result in a phenotype under laboratory conditions.; Function: in S. cerevisiae overexpression of EXG1 on a 2 mu plasmid led to reduction in a cell wall beta 1,6-glucan and caused killer resistance in wild type cells.; Title: strong similarity to exo-1,3-beta-glucanase KlEXG1 - Kluyveromyces lactis; extracellular/secretion proteins; See PMID 10029988; See PMID 7565587; uncharacterized protein 222858 4982424 An08g01100 Aspergillus niger uncharacterized protein XP_001392228.1 221698 D 5061 CDS An08g01110 84591578 complement(join(223241..223594,224717..224734)) VIII 1 NT_166524.1 Function: VTC1 of S. cerevisiae is involved in the distribution of V-ATPase and other membrane proteins.; Function: in S. pombe Nrf1p functions as a negative regulator of Cdc42p within the cell polarity pathway.; Function: in S. pombe overexpression of nrf1(+) resulted in dose-dependent lethality, with cells exhibiting an ellipsoidal morphology indicative of loss of polarized cell growth along with partially delocalized cortical actin and large vacuoles.; Function: null mutations of S. cerevisiae VTC1 cause pleiotropic effects on metal-ion resistance or sensitivity and distribution of membrane proteins in different targets.; Remark: the systematic name for VTC1, which is also known as NRF1, is YER072W.; Title: strong similarity to Vtc1 - Saccharomyces cerevisiae; See PMID 10480897; See PMID 10628977; uncharacterized protein 224734 84591578 An08g01110 Aspergillus niger uncharacterized protein XP_059601130.1 223241 R 5061 CDS An08g01120 4982426 join(226530..226939,227003..227291) VIII 1 NT_166524.1 Function: isoJ from Rhodococcus sp. is placed in a metabolic pathway representing a catabolic route for isoprene involving epoxidation by a monooxygenase,conjugation to glutathione, and oxidation of the hydroxyl group to a carboxylate.; Function: isoJ from Rhodococcus sp. shows activity with 1-chloro-2,4-dinitrobenzene and 3,4-dichloro-1-nitrobenzene but not with 1,2-epoxy-2-methyl-3-butene.; Title: strong similarity to glutathione S-transferase isoJ - Rhodococcus sp.; See PMID 10715003; uncharacterized protein 227291 4982426 An08g01120 Aspergillus niger uncharacterized protein XP_001392230.3 226530 D 5061 CDS An08g01130 4982427 228695..229528 VIII 1 NT_166524.1 Function: aph(2'')-Id from E. casseliflavus is an aminoglycoside-modifying phosphotransferase confering gentamicin resistance. .; Title: similarity to gentamicin resistance gene aph(2)-Id - Enterococcus casseliflavus; See PMID 9593155; uncharacterized protein 229528 4982427 An08g01130 Aspergillus niger uncharacterized protein XP_001392231.1 228695 D 5061 CDS An08g01140 4982428 join(230293..230322,230453..230491,230582..230656,230719..231003) VIII 1 NT_166524.1 Function: in S. pombe Dlc1 is required for the function of the telomere associated-spindle pole body.; Remark: information regarding S. pombe Dlc1 has not yet been published and is available via http://www. sanger. ac. uk/cgi-bin/yeastpub/GN_KW_search. p.; Similarity: S. pombe Dlc1 is similar to human TCTEX-1 dynein light chain.; Title: strong similarity to cytoplasmic dynein light chain dlc1p - Schizosaccharomyces pombe; cytoskeleton; uncharacterized protein 231003 4982428 An08g01140 Aspergillus niger uncharacterized protein XP_001392232.1 230293 D 5061 CDS An08g01150 4982429 complement(join(231638..231898,232121..232276,232338..232833,232891..232912,233008..233029)) VIII 1 NT_166524.1 Function: LST8 from S. cerevisiae is required for amino acid permease transport from the Golgi to the cell surface.; Remark: YNL006w is the systematic name for LST8.; Remark: information regarding LST8 from S. cerevisiae has not yet been published and is available via the SGD database at http://genome-www. stanford. edu/cgi-bin/SGD/genehunter.; Similarity: the predicted A. niger protein shows high similarity to members of the WD-40 repeat G-beta transducin family.; Title: strong similarity to G beta-like protein Lst8 - Saccharomyces cerevisiae; uncharacterized protein 233029 4982429 An08g01150 Aspergillus niger uncharacterized protein XP_059601131.1 231638 R 5061 CDS An08g01160 4982430 233811..235769 VIII 1 NT_166524.1 Similarity: the Syndecan family shares transmembrane domains, while none are predicted for the A. niger protein.; Title: weak similarity to heparin sulfate proteoglycan syndecan Sdc - Drosophila melanogaster; See PMID 8159748; uncharacterized protein 235769 4982430 An08g01160 Aspergillus niger uncharacterized protein XP_059601132.1 233811 D 5061 CDS An08g01170 4982431 complement(join(238204..238775,238828..239233)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein SPAC15A10.09c - Schizosaccharomyces pombe; uncharacterized protein 239233 4982431 An08g01170 Aspergillus niger uncharacterized protein XP_001392235.1 238204 R 5061 CDS An08g01180 4982432 join(241022..241583,241646..242245,242300..242520) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein SC4G1.04c - Streptomyces coelicolor; uncharacterized protein 242520 4982432 An08g01180 Aspergillus niger uncharacterized protein XP_001392236.1 241022 D 5061 CDS An08g01190 4982433 join(242948..243100,243179..243311,243444..243829) VIII 1 NT_166524.1 Catalytic activity: catalyse the reaction,Acetyl-CoA + peptide <=> CoA + N-acetylpeptide.; Complex: in S. cerevisiae Ard1 forms a complex with Nat1 and ARD1-ARD1 homodimers.; Function: in S. cerevisiae Ard1 and Nat1 are required for the N-terminal acetyltransferase activity,with Nat1 representing the catalytic subunit.; Function: in S. cerevisiae Ard1 is required for full repression of the silent mating type locus HML, for sporulation, and for entry into G0.; Remark: polymorphism in the human peptide alpha-N-acetyl transferases NAT1 and NAT2 are associated with cancer susceptibility.; Title: strong similarity to subunit of the major N alpha-acetyltransferase Ard1 - Saccharomyces cerevisiae; cytoplasm; See PMID 1600941; uncharacterized protein 243829 4982433 An08g01190 Aspergillus niger uncharacterized protein XP_059601133.1 242948 D 5061 CDS An08g01200 4982434 complement(244151..246235) VIII 1 NT_166524.1 Similarity: predicted A. niger protein shows likely unspecific similarity to proline rich proteins.; Title: weak similarity to hydroxyproline-rich glycoprotein - Nicotiana tabacum; uncharacterized protein 246235 4982434 An08g01200 Aspergillus niger uncharacterized protein XP_001392238.1 244151 R 5061 CDS An08g01210 4982435 complement(join(247046..247814,247864..248036,248087..248290,248343..248637,248694..249067,249125..249271,249329..249439,249505..249642,249722..249844)) VIII 1 NT_166524.1 Remark: the predicted A. niger protein shows strong similarity to a eucaryotic kinase domain from the Pfam database as well as to a ser/thr protein kinase group of COGs.; Title: strong similarity to hypothetical 105-kDa kinase-like protein - Mus musculus; uncharacterized protein 249844 4982435 An08g01210 Aspergillus niger uncharacterized protein XP_059601134.1 247046 R 5061 CDS An08g01220 84591579 join(251341..251518,251689..251804) VIII 1 NT_166524.1 Function: Myb is a DNA-binding transcriptional regulator.; Similarity: the predicted A. niger protein is 200 aa shorter than OSMYB2 from O. sativa.; Title: weak similarity to myb-related protein 2 OSMYB2 - Oryza sativa; uncharacterized protein 251804 84591579 An08g01220 Aspergillus niger uncharacterized protein XP_059601135.1 251341 D 5061 CDS An08g01230 4982437 complement(join(252197..252405,252461..254800,254870..255143,255201..255387,255754..255921,256009..256322,256556..256807)) VIII 1 NT_166524.1 Function: in S. cerevisiae Pbp1p appears to function in the nucleus to promote proper polyadenylation.; Remark: the systematic name for Pbp1 of S. cerevisiae is YGR178C.; Title: similarity to poly(A)-binding protein interacting factor Pbp1 - Saccharomyces cerevisiae; nucleus; See PMID 9819425; uncharacterized protein 256807 4982437 An08g01230 Aspergillus niger uncharacterized protein XP_001392241.3 252197 R 5061 CDS An08g01240 4982438 join(259282..259443,259545..260380,260564..261194,261263..262459) VIII 1 NT_166524.1 Complex: in S. cerevisiae Gic2p is a Cdc42p effector and interacted with Aip3p by coimmunoprecipitation and two-hybrid analysis.; Function: AIP3/BUD6 from S. cerevisiae is not essential for mitotic growth but is necessary for normal morphogenesis and deletion of AIP3 causes gross defects in cell and cytoskeletal polarity.; Localization: Aip3p from S. cerevisiae localizes at the cell cortex where cytoskeleton assembly must be achieved to execute polarized cell growth.; Localization: in S. cerevisiae Aip3p localization is mediated by the secretory pathway.; Remark: AIP3 from S. cerevisiae is also known as BUD6.; Title: similarity to actin-interacting protein Aip3 - Saccharomyces cerevisiae; cytoskeleton; See PMID 9247651; See PMID 10938101; uncharacterized protein 262459 4982438 An08g01240 Aspergillus niger uncharacterized protein XP_059601136.1 259282 D 5061 CDS An08g01250 4982439 complement(join(263638..264697,264764..266055)) VIII 1 NT_166524.1 Function: CIP7 from A. thaliana acts as a positive regulator of light-regulated genes and is a potential direct downstream target of COP1 for mediating light control of gene expression.; Function: CIP7 from A. thaliana is a novel nuclear protein that contains transcriptional activation activity without a recognizable DNA binding motif.; Similarity: similarity is from N-terminal 100 aa of predicted A. niger protein to central part of CIP7 from A. thaliana.; Similarity: the N-terminal 100 aa of predicted A. niger protein also show similarity to C-terminus of the DEAD box RNA helicase CHR1 from Candida albicans.; Title: weak similarity to COP1-interacting protein 7 CIP7 - Arabidopsis thaliana; See PMID 9668129; uncharacterized protein 266055 4982439 An08g01250 Aspergillus niger uncharacterized protein XP_001392243.1 263638 R 5061 CDS An08g01260 4982440 complement(join(266812..267421,267499..267731,267788..267982)) VIII 1 NT_166524.1 Catalytic activity: TH4 from Pinus taeda catalyses the NADPH-dependent reduction of phenylcoumaran benzylic ethers.; Function: TH4 from T. heterophylla is involved in the biosynthesis of important phenylpropanoid-derived plant defense compounds.; Title: similarity to phenylcoumaran benzylic ether reductase TH4 - Tsuga heterophylla; See PMID 10066819; uncharacterized protein 267982 4982440 An08g01260 Aspergillus niger uncharacterized protein XP_059601137.1 266812 R 5061 CDS An08g01270 4982441 complement(join(269465..270367,270423..270972,271018..271143,271191..271303,271354..271388,271437..271537,271592..271602)) VIII 1 NT_166524.1 Catalytic activity: gamma-glutamylcysteine synthetases catalyse the reaction, ATP + L-glutamate + L-cysteine <=> ADP + phosphate + gamma-L-glutamyl-L-cysteine.; Function: S. pombe GSH1 encodes the rate-limiting step in glutathione biosynthesis.; Function: The tripeptide gamma-L-glutamyl-L-cystinylglycine (glutathione) is one of the major antioxidant molecules of cells and is thought to play a vital role in buffering the cell against reactive oxygen species and toxic electrophiles.; Induction: expression of S. pombe GSH1 is activated by the yAP-1 transcriptional regulatior.; Induction: in S. cerevisiae the transcription factors Met-4, Met-31, and Met-32 are essential for cadmium-mediated regulation of GSH1 expression.; Repression: in S. cerevisiae the DNA-binding protein Cbf1 appears to play a negative role in controlling GSH1 expression.; Title: strong similarity to gamma-glutamylcysteine synthase gcs1p - Schizosaccharomyces pombe; See PMID 10921921; See PMID 7915005; uncharacterized protein 271602 4982441 An08g01270 Aspergillus niger uncharacterized protein XP_059601138.1 269465 R 5061 CDS An08g01280 4982442 complement(join(272912..273031,273466..273870)) VIII 1 NT_166524.1 Title: weak similarity to hypothetical protein BH1676 - Bacillus halodurans; uncharacterized protein 273870 4982442 An08g01280 Aspergillus niger uncharacterized protein XP_001392246.3 272912 R 5061 CDS An08g01290 4982443 join(275360..275470,275602..275811,275935..276216,276326..276976,277024..277134) VIII 1 NT_166524.1 Complex: in S. cerevisiae ArgRI and Mcm1, two MADS-box proteins, and ArgRII form a three-component protein complex.; Function: ArgRII of S. cerevisiae is the sensor of the effector arginine.; Function: in S. cerevisiae repression of arginine anabolic genes and induction of arginine catabolic genes are mediated by a three-component protein complex,interacting with specific DNA sequences in the presence of arginine.; Similarity: ArgRII of S. cerevisiae is a zinc cluster protein with an arginine binding domain.; Similarity: similarity from predicted A. niger protein to S. cerevisiae ArgRII, which is 400 aa longer, is restricted to the N-terminal 100 aa of each protein.; Title: weak similarity to regulator protein Arg81 -Saccharomyces cerevisiae; See PMID 10688655; uncharacterized protein 277134 4982443 An08g01290 Aspergillus niger uncharacterized protein XP_059601139.1 275360 D 5061 CDS An08g01300 4982444 complement(277228..278514) VIII 1 NT_166524.1 Remark: fructosyl amino acid oxidase is an enzyme that can be used for the determination of glycated proteins in blood samples from diabetic patients.; Remark: fructosyl amino acid oxidase was found only in the strains of four genera of fungi, Aspergillus,Fusarium, Gibberella, and Penicillium.; Remark: patents for fructosyl amino acid oxidase from different fungal strains exist.; Title: strong similarity to fructosyl amino acid oxidase faop - Penicillium janthinellum; See PMID 8534116; See PMID 9022674; See PMID 9139700; uncharacterized protein 278514 4982444 An08g01300 Aspergillus niger uncharacterized protein XP_001392248.1 277228 R 5061 CDS An08g01310 4982445 complement(279412..280962) VIII 1 NT_166524.1 Function: in S. cerevisiae mutants (dal5) that lack allantoate transport have been isolated, these strains also exhibit a 60% loss of allantoin transport capability.; Regulation: in S. cerevisiae Dal5 appears to be sensitive to nitrogen catabolite repression, feedback inhibition, and trans-inhibition.; Regulation: in S. cerevisiae allantoate uptake is constitutive.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 3275614; See PMID 3549700; uncharacterized protein 280962 4982445 An08g01310 Aspergillus niger uncharacterized protein XP_001392249.1 279412 R 5061 CDS An08g01320 4982446 join(281302..281338,281387..282242,282294..282392,282454..283883,283939..284124,284176..285379,285441..285585) VIII 1 NT_166524.1 Catalytic activity: 5-Oxoprolinase catalyzes a reaction in which the endergonic cleavage of 5-oxo-L-proline to form L-glutamate is coupled to the exergonic hydrolysis of ATP to ADP and inorganic phosphate.; Title: strong similarity to ATP-hydrolyzing 5-oxoprolinase - Rattus norvegicus; See PMID 8943290; uncharacterized protein 285585 4982446 An08g01320 Aspergillus niger uncharacterized protein XP_001392250.1 281302 D 5061 CDS An08g01330 4982447 join(286290..286836,286900..287588) VIII 1 NT_166524.1 Similarity: aa 252-319 of the predicted A. niger protein show a protein kinase signature.; Title: similarity to hypothetical protein F3E22.6 -Arabidopsis thaliana; uncharacterized protein 287588 4982447 An08g01330 Aspergillus niger uncharacterized protein XP_059601140.1 286290 D 5061 CDS An08g01340 4982448 join(288992..289154,289247..289464,289524..289710,289765..290792,290848..290919) VIII 1 NT_166524.1 Function: stcS from A. nidulans is required for the conversion of versicolorin A to sterigmatocystin.; Pathway: stcS of A. nidulans is involved in sterigmatocystin biosynthesis.; Remark: sterigmatocystin is a polyketide-derived mycotoxin.; Similarity: stcS (formerly verB) from A. nidulans belongs to the P-450 monooxygenase superfamily.; Title: strong similarity to cytochrome P450 monooxygenase stcS - Aspergillus nidulans; See PMID 10618248; See PMID 7486998; uncharacterized protein 290919 4982448 An08g01340 Aspergillus niger uncharacterized protein XP_059601141.1 288992 D 5061 CDS An08g01350 4982449 complement(join(291087..291247,291319..291478,291533..291873,291929..292260,292322..292506)) VIII 1 NT_166524.1 Complex: in vitro SRPKs bound unphosphorylated SF2/ASF but did not bind phosphorylated SF2/ASF.; Function: SRPKs may have regulatory roles in the assembly and localization of Serine/arginine-rich (SR) splicing factors like SF2/ASF.; Function: in human HeLa cells expression of an SRPK2 kinase-inactive mutant caused accumulation of SF2/ASF in the cytoplasm.; Title: similarity to serine/threonine protein kinase SRPK1 - Arabidopsis thaliana; cytoplasm; deleted EC_number 2.7.1.37; See PMID 10196197; uncharacterized protein 292506 4982449 An08g01350 Aspergillus niger uncharacterized protein XP_001392253.1 291087 R 5061 CDS An08g01360 4982450 293348..294049 VIII 1 NT_166524.1 Title: similarity to hypothetical protein G11A3.030 - Neurospora crassa; uncharacterized protein 294049 4982450 An08g01360 Aspergillus niger uncharacterized protein XP_001392254.3 293348 D 5061 CDS An08g01370 4982451 join(294970..295058,295182..295211,295288..295374,295444..296155) VIII 1 NT_166524.1 Function: Odc2 from S. cerevisiae is a mitochondrial 2-oxodicarboxylate transport protein.; Function: S. cerevisiae Odc2 transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria in a strict counter-exchange mechanism.; Function: the main physiological roles of Odc1p and Odc2p are probably to supply 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol where they are used in the biosynthesis of lysine and glutamate respectively, and in lysine catabolism.; Remark: the ALOM Algorithm does not predict transmembrane regions for the predicted A. niger protein,while Algorithms used by Swissprot predict TM regions for the nearly identical S. cerevisiae aa sequence.; Similarity: Odc1 and Odc2 from S. cerevisiae is a member of the family of mitochondrial carrier proteins.; Title: strong similarity to Oxodicarboxylate carrier Odc2 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 11013234; uncharacterized protein 296155 4982451 An08g01370 Aspergillus niger uncharacterized protein XP_001392255.1 294970 D 5061 CDS An08g01380 84591580 complement(297457..298929) VIII 1 NT_166524.1 Function: the mutation of glcd in A. nidulans leads to a loss of mitochondrial FAD-dependent sn-glycerol-3-phosphate dehydrogenase.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to transcriptional activator glcD - Aspergillus nidulans; See PMID 2259335; uncharacterized protein 298929 84591580 An08g01380 Aspergillus niger uncharacterized protein XP_059601142.1 297457 R 5061 CDS An08g01390 84591581 join(<300160..300245,300329..300552,300641..300975) VIII 1 NT_166524.1 Function: in A. thaliana GBF2 binds to the g-box motif (5'-ccacgtgg-3') of the rbcs-1a gene promoter.; Similarity: A. thaliana GBF2 contains a basic leucine-zipper motif.; Similarity: only central region of predicted A. niger protein shows similarity to central region of A. thaliana GBF2.; Title: weak similarity to g-box binding factor 2 GBF2 - Arabidopsis thaliana [truncated ORF]; See PMID 1373374; uncharacterized protein 300975 84591581 An08g01390 Aspergillus niger uncharacterized protein XP_059606152.1 300160 D 5061 CDS An08g01392 4982452 complement(join(<301172..301221,301571..>301782)) VIII 1 NT_166524.1 Remark: the ORF is N-terminally truncated due to border of contig.; hypothetical protein [truncated ORF] 301782 4982452 An08g01392 Aspergillus niger hypothetical protein [truncated ORF] XP_059606153.1 301172 R 5061 CDS An08g01400 84591582 join(302609..302687,302853..302949,303023..303168,303236..303399,303487..303549,303746..303904,304041..304184,304256..304300,304398..304444,304581..304700,304806..304824,304948..305020,305069..305115,305295..305510) VIII 1 NT_166524.1 hypothetical protein 305510 84591582 An08g01400 Aspergillus niger hypothetical protein XP_059601143.1 302609 D 5061 CDS An08g01410 4982456 join(306831..307059,307386..307506,307768..307918,308264..308416) VIII 1 NT_166524.1 Function: Sft2p of S. cerevisiae is membrane protein involved in traffic to the Golgi complex.; Remark: systematic genename of SFT2 is YBL102w.; Title: strong similarity to ER-Golgi transport protein Sft2 - Saccharomyces cerevisiae; See PMID 10406798; uncharacterized protein 308416 4982456 An08g01410 Aspergillus niger uncharacterized protein XP_001392260.1 306831 D 5061 CDS An08g01420 4982457 complement(309901..311238) VIII 1 NT_166524.1 Catalytic activity: chorismate + l-glutamine = anthranilate + pyruvate + l-glutamate.; Pathway: anthranilate synthase catalyzes the first step in biosynthesis of tryptophan.; Title: similarity to anthranilate synthase component I trpE - Clostridium thermocellum; See PMID 2732211; uncharacterized protein 311238 4982457 An08g01420 Aspergillus niger uncharacterized protein XP_001392261.1 309901 R 5061 CDS An08g01430 4982458 join(312792..312844,313132..313382,313446..313563,313641..313903,314114..314282,314318..314378) VIII 1 NT_166524.1 Title: weak similarity to hypothetical protein Rv0598c - Mycobacterium tuberculosis; uncharacterized protein 314378 4982458 An08g01430 Aspergillus niger uncharacterized protein XP_059601144.1 312792 D 5061 CDS An08g01440 4982459 complement(join(314977..316114,316183..316232)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein SCD19.11 -Streptomyces coelicolor; uncharacterized protein 316232 4982459 An08g01440 Aspergillus niger uncharacterized protein XP_059601145.1 314977 R 5061 CDS An08g01450 84591583 join(316856..318059,318479..318708,318749..318791,318825..318892) VIII 1 NT_166524.1 hypothetical protein 318892 84591583 An08g01450 Aspergillus niger hypothetical protein XP_059601146.1 316856 D 5061 CDS An08g01460 4982461 join(319227..319286,319339..319848,319908..320870) VIII 1 NT_166524.1 Title: similarity to hypothetical transcriptions regulator CAB91400.2 - Neurospora crassa; uncharacterized protein 320870 4982461 An08g01460 Aspergillus niger uncharacterized protein XP_059601147.1 319227 D 5061 CDS An08g01470 84591584 complement(join(321710..323700,323757..323907)) VIII 1 NT_166524.1 hypothetical protein 323907 84591584 An08g01470 Aspergillus niger hypothetical protein XP_059601148.1 321710 R 5061 CDS An08g01480 4982463 complement(325032..327497) VIII 1 NT_166524.1 Remark: The tRNA ligase TRL1 of S. cerevisiae is one of the components required for splicing of yeast tRNA precursors in vitro.; Title: strong similarity to tRNA ligase Trl1 -Saccharomyces cerevisiae; See PMID 3512545; See PMID 3277966; uncharacterized protein 327497 4982463 An08g01480 Aspergillus niger uncharacterized protein XP_001392267.1 325032 R 5061 CDS An08g01490 4982464 join(327799..327934,327967..328670) VIII 1 NT_166524.1 Title: similarity to hypothetical ankyrin-repeat protein SPCP1E11.10 - Schizosaccharomyces pombe; uncharacterized protein 328670 4982464 An08g01490 Aspergillus niger uncharacterized protein XP_059601149.1 327799 D 5061 CDS An08g01500 4982465 join(329284..329549,329637..330123) VIII 1 NT_166524.1 Title: weak similarity to hypothetical protein T4D2.50 - Arabidopsis thaliana; uncharacterized protein 330123 4982465 An08g01500 Aspergillus niger uncharacterized protein XP_001392269.1 329284 D 5061 CDS An08g01510 4982466 complement(join(330327..330820,330885..331429,331494..331612)) VIII 1 NT_166524.1 Function: Dpp1p of S. cerevisiae contains diacylglycerol pyrophosphate (DGPP) phosphatase and Mg2+-independent phosphatidate (PA) phosphatase activity.; Remark: systematic genename of S. cerveisiae DPP1 is YDR284c.; Title: similarity to diacylglycerol pyrophosphate phosphatase Dpp1 - Saccharomyces cerevisiae; See PMID 11016943; See PMID 11139591; uncharacterized protein 331612 4982466 An08g01510 Aspergillus niger uncharacterized protein XP_001392270.1 330327 R 5061 CDS An08g01520 4982467 complement(join(332044..332246,332297..332624,332695..332959,333017..333156)) VIII 1 NT_166524.1 Catalytic activity: Alcohol + NADP(+) = Aldehyde + NADPH.; Remark: Alcohol dehydrogenase is identical with aldehyde reductase.; Similarity: belongs to the Aldo/Keto reductase family.; Title: strong similarity to alcohol dehydrogenase (NADP+) ALR - Sus scrofa; See PMID 7552731; See PMID 9329083; uncharacterized protein 333156 4982467 An08g01520 Aspergillus niger uncharacterized protein XP_001392271.1 332044 R 5061 CDS An08g01530 84591585 join(335270..335297,335496..335542) VIII 1 NT_166524.1 hypothetical protein 335542 84591585 An08g01530 Aspergillus niger hypothetical protein XP_059601150.1 335270 D 5061 CDS An08g01540 4982469 complement(join(336372..336675,336774..336953,337044..337051)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein PA4177 -Pseudomonas aeruginosa; uncharacterized protein 337051 4982469 An08g01540 Aspergillus niger uncharacterized protein XP_001392273.1 336372 R 5061 CDS An08g01550 4982470 join(337790..337839,337933..337967,338113..338300) VIII 1 NT_166524.1 Remark: S. cerevsisiae cox19 defect affects specifically the cytochrome oxidase activity in mitochondria.; Remark: it is assumed that YLL018c-a (COX19) of S. cerevisiae acts as cytochrome c oxidase subunit, as an S. cerevisiae clone containing this region complements respiratory deficient mutants of group G188 (Dr. A. Tzagoloff).; Title: strong similarity to hypothetical subunit of probable cytochrome c oxidase Cox19 - Saccharomyces cerevisiae; uncharacterized protein 338300 4982470 An08g01550 Aspergillus niger uncharacterized protein XP_059601151.1 337790 D 5061 CDS An08g01560 4982471 join(338697..339969,340025..341346,341448..341582) VIII 1 NT_166524.1 Title: similarity to hypothetical protein SPBC543.04 - Schizosaccharomyces pombe; uncharacterized protein 341582 4982471 An08g01560 Aspergillus niger uncharacterized protein XP_059601152.1 338697 D 5061 CDS An08g01570 84591586 complement(join(344269..344561,344599..344658,344828..344861,344918..345044,345080..345151,345242..345283,345444..345454)) VIII 1 NT_166524.1 hypothetical protein 345454 84591586 An08g01570 Aspergillus niger hypothetical protein XP_059601153.1 344269 R 5061 CDS An08g01580 4982473 346550..348805 VIII 1 NT_166524.1 Function: rat Nopp140 is a nucleolar phosphoprotein of 140 kd that was originally identified and purified as a nuclear localization signal (NLS)-binding protein.; Function: rat Nopp140 is one of the most phosphorylated proteins in the cell, and NLS binding was dependent on phosphorylation.; Function: rat Nopp140 was shown to shuttle between the nucleolus and the cytoplasm and is suggested to function as a chaperone for import into and/or export from the nucleolus.; Similarity: shows also some similarity to the S. cerevisiae SRP40 gene product which is immunologically and structurally related to rat Nopp140.; Title: similarity to nucleolus-cytoplasm shuttle phosphoprotein nopp140 - Rattus norvegicus; See PMID 8702624; See PMID 1623516; uncharacterized protein 348805 4982473 An08g01580 Aspergillus niger uncharacterized protein XP_001392277.3 346550 D 5061 CDS An08g01590 4982474 join(350727..351217,351324..352143) VIII 1 NT_166524.1 Remark: human SLP-2 may link stomatin or other integral membrane proteins to the peripheral cytoskeleton and thereby play a role in regulating ion channel conductances or the organization of sphingolipid and cholesterol-rich lipid rafts.; Title: similarity to membrane associated protein SLP-2 - Homo sapiens; See PMID 10713127; uncharacterized protein 352143 4982474 An08g01590 Aspergillus niger uncharacterized protein XP_001392278.1 350727 D 5061 CDS An08g01600 4982475 join(352985..353021,353183..353257,353345..353566,353636..356386,356438..356535) VIII 1 NT_166524.1 Complex: Hir1p and Hir2p f S. cerevisiae function as transcriptional corepressors that form a protein complex in vivo to regulate histone gene transcription.; Function: HIR1 and HIR2 of S. cerevisiae contain nuclear targeting signals and they play important roles in the transcription of six of the eight core histone genes during the S. cerevisiae cell cycle.; Function: The products of the HIR1 and HIR2 of S. cerevisiae genes have been defined genetically as repressors of histone gene transcription in S. cerevisiae.; Title: similarity to histone transcription regulator Hir1 - Saccharomyces cerevisiae; See PMID 8417331; See PMID 9001207; uncharacterized protein 356535 4982475 An08g01600 Aspergillus niger uncharacterized protein XP_001392279.1 352985 D 5061 CDS An08g01610 4982476 join(357582..357656,357901..358458,358671..359222) VIII 1 NT_166524.1 Title: strong similarity to hypothetical GTP-binding protein SPAC27E2.03c - Schizosaccharomyces pombe; uncharacterized protein 359222 4982476 An08g01610 Aspergillus niger uncharacterized protein XP_001392280.1 357582 D 5061 CDS An08g01620 4982477 359917..360261 VIII 1 NT_166524.1 Title: similarity to hypothetical protein YER007c-a - Saccharomyces cerevisiae; uncharacterized protein 360261 4982477 An08g01620 Aspergillus niger uncharacterized protein XP_001392281.3 359917 D 5061 CDS An08g01630 4982478 complement(join(360531..361259,361304..361779,361826..362093,362143..362269,362312..363537,363592..363855)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein GH03694 -Drosophila melanogaster; uncharacterized protein 363855 4982478 An08g01630 Aspergillus niger uncharacterized protein XP_059601154.1 360531 R 5061 CDS An08g01640 4982479 join(364210..364212,364285..365261,365317..365362) VIII 1 NT_166524.1 Remark: human SGT interacts with the nonstructural protein NS1 of parvovirus H-1.; Title: strong similarity to small glutamine-rich tetratricopeptide protein SGT - Homo sapiens; See PMID 9557704; See PMID 9740675; uncharacterized protein 365362 4982479 An08g01640 Aspergillus niger uncharacterized protein XP_001392283.1 364210 D 5061 CDS An08g01650 4982480 complement(join(366126..366801,366859..367709)) VIII 1 NT_166524.1 Function: Mpi1p of S. cerevisiae is a component of the protein import system of the yeast mitochondrial inner membrane.; Function: Mpi1p of S. cerevisiae is a low abundance and constitutively expressed hydrophilic 48. 8 kDa protein that is essential for cell viability. Mpi1p is synthesized with a characteristic mitochondrial targeting sequence at its amino-terminus, which is most probably proteolytically removed during import.; Remark: The mitochondrial inner membrane import site protein ISP45 has been purified to homogeneity and identified as the product of the nuclear MPI1 gene.; Title: similarity to mitochondrial import protein Mpi1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8344245; See PMID 1396562; uncharacterized protein 367709 4982480 An08g01650 Aspergillus niger uncharacterized protein XP_001392284.3 366126 R 5061 CDS An08g01660 4982481 368176..368883 VIII 1 NT_166524.1 Title: similarity to mitochondrial ribosomal protein of the small subunit Yms18 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9151978; See PMID 9445368; mitochondrial 37S ribosomal protein uS11m 368883 4982481 An08g01660 Aspergillus niger mitochondrial 37S ribosomal protein uS11m XP_001392285.1 368176 D 5061 CDS An08g01670 84591587 368981..369259 VIII 1 NT_166524.1 hypothetical protein 369259 84591587 An08g01670 Aspergillus niger hypothetical protein XP_059601155.1 368981 D 5061 CDS An08g01680 4982483 370273..373710 VIII 1 NT_166524.1 Title: similarity to hypothetical membrane protein YML002w - Saccharomyces cerevisiae; uncharacterized protein 373710 4982483 An08g01680 Aspergillus niger uncharacterized protein XP_001392287.3 370273 D 5061 CDS An08g01690 4982484 complement(374625..375653) VIII 1 NT_166524.1 hypothetical protein 375653 4982484 An08g01690 Aspergillus niger hypothetical protein XP_001392288.3 374625 R 5061 CDS An08g01700 4982485 join(376630..376740,376809..376891,376963..377017) VIII 1 NT_166524.1 Title: similarity to protease inhibitor from patent WO9820133-A2 - Zea mays; uncharacterized protein 377017 4982485 An08g01700 Aspergillus niger uncharacterized protein XP_001392289.1 376630 D 5061 CDS An08g01710 4982486 complement(join(377312..378210,378261..378360,378411..378499,378552..378566,378615..378727,378862..379056,379123..379229)) VIII 1 NT_166524.1 Catalytic activity: alpha-L-arabinofuranosidases catalyze the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.; Function: Bacillus stearothermophilus T-6 produces an alpha-L-arabinofuranosidase when grown in the presence of L-arabinose, sugar beet arabinan, or oat spelt xylan.; Remark: The enzyme acts cooperatively with T-6 xylanase in hydrolyzing oat spelt xylan, and L-arabinose,xylose, and xylobiose are detected as the end reaction products.; Title: strong similarity to alpha-L-arabinofuranosidase abfA - Bacillus stearothermophilus; See PMID 7887599; uncharacterized protein 379229 4982486 An08g01710 Aspergillus niger uncharacterized protein XP_001392290.1 377312 R 5061 CDS An08g01720 4982487 join(380004..380030,380087..380132,380188..380263,380311..380502,380558..380801,380850..381106,381163..381832) VIII 1 NT_166524.1 Function: QUTD in A. nidulans facilitates the uptake of quinic acid into the mycelium thereby inducing the enzymes of the quinic acid utilizetion pathway.; Pathway: the quinic acid ulitization (qut) pathway in A. nidulans is a dispensable carbon utilization pathway that catabolizes quinate to protocatechuate via dehydroquinate and dehydroshikimate.; Similarity: also shows strong similarity to various sugar transporters of diverse species.; Title: strong similarity to quinate transport protein qutD - Aspergillus nidulans; See PMID 8670107; See PMID 976880; uncharacterized protein 381832 4982487 An08g01720 Aspergillus niger uncharacterized protein XP_001392291.1 380004 D 5061 CDS An08g01730 4982488 complement(join(382398..382966,383061..383226)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein CG14480 -Drosophila melanogaster; uncharacterized protein 383226 4982488 An08g01730 Aspergillus niger uncharacterized protein XP_001392292.1 382398 R 5061 CDS An08g01740 4982489 join(384386..384408,384510..384638,384707..384955,385006..385501) VIII 1 NT_166524.1 Function: GCY1 of S. cerevisiae encodes a putative glycerol dehydregonase (PubMed 9038161).; Function: uronate dehydrogenase of patent W29217 is used in L-ascorbic acid production from D-glucuronic or galacturonic acids.; Induction: GCY1 of S. cerevisiae is upregulated under salt stress conditions (PubMed 9038161).; Induction: GCY1 of S. cerevisiae is upregulated when galactose is the sole energy source but is low as soon as glucose is present (PubMed 2199324).; Pathway: GCY1 of S. cerevisiae is thought to be involved in glycerol dissimilation via dihydroxyaceton (PubMed 9038161).; Similarity: GCY1 of S. cerevisiae belongs to the family of NADPH-dependent aldo-keto reductases (PubMed 11306072).; Similarity: strong similarity to protein patent database entry GENESEQPROT:W29217.; Similarity: the sequence of uronate dehydrogenase of patent W29217 is identical to that of the GCY1 gene product of S. cerevisiae.; Title: strong similarity to uronate dehydrogenase from patent DE19604798-A1 - Saccharomyces cerevisiae; See PMID 9038161; See PMID 11306072; See PMID 2199324; uncharacterized protein 385501 4982489 An08g01740 Aspergillus niger uncharacterized protein XP_001392293.1 384386 D 5061 CDS An08g01750 4982490 join(385990..386042,386092..387421) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein EAA65867.1 - Aspergillus nidulans; uncharacterized protein 387421 4982490 An08g01750 Aspergillus niger uncharacterized protein XP_001392294.1 385990 D 5061 CDS An08g01760 4982491 join(388278..388543,388606..388859,388925..389062,389112..389369,389427..389668,389722..389766) VIII 1 NT_166524.1 Catalytic activity: exocellobiohydrolases cleave the beta-1,4 glycosidic bond releasing cellobiose from the non-reducing end of cellulose.; Pathway: fungal cellobiohydrolases are unique enzymes capable of degrading highly ordered cellulose.; Similarity: belongs to the cellulase family B (family 6 of glycosylhydrolases).; Similarity: shows also stong homology to cellulose 1, 4-beta-cellobiosidase (EC 3. 2. 1. 91) II (exocellobiohydrolase II, CBHII) of Trichoderma reesei (Hypocrea jecorina) - PubMed 8875646;3596237.; Similarity: strong similarity to protein patent database entry GENESEQPROT:W25789.; Title: strong similarity to cellulase from patent WO9733982-A1 - Acremonium cellulolyticus; extracellular/secretion proteins; uncharacterized protein 389766 4982491 An08g01760 Aspergillus niger uncharacterized protein XP_001392295.3 388278 D 5061 CDS An08g01770 4982492 join(390340..390396,390807..391052,391115..391606) VIII 1 NT_166524.1 Complex: the CK2 holoenzyme of S. pombe is a heterotetramer composed of an alpha and an alpha' catalytic chain and two beta regulatory chains.; Function: Ckb1 in S. pombe is a positive regulator of CK2 enzyme activity.; Function: casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.; Pathway: CK2 in S. pombe is a key regulatory enzyme involved in the control of various cellular processes including cell cycle progression and cell growth.; Similarity: casein kinase II is a highly conserved serine/threonine protein kinase that is ubiquitous in eukaryotic organisms.; Title: strong similarity to protein kinase CK2 (casein kinase II) beta subunit ckb1p - Schizosaccharomyces pombe; deleted EC_number 2.7.1.37; See PMID 8264625; See PMID 9427841; See PMID 1099477; uncharacterized protein 391606 4982492 An08g01770 Aspergillus niger uncharacterized protein XP_001392296.1 390340 D 5061 CDS An08g01780 4982493 complement(join(391994..392034,392113..392909,392972..393111)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein B14D6.320 - Neurospora crassa; uncharacterized protein 393111 4982493 An08g01780 Aspergillus niger uncharacterized protein XP_001392297.3 391994 R 5061 CDS An08g01790 4982494 join(393604..393611,393672..393711,393788..394257,394323..394902) VIII 1 NT_166524.1 Complex: TIF3H1 in A. thaliana is part of the heterodecameric eIF3 complex.; Function: eIF3 is required for binding of mRNA to 40S ribosomal subunits, stabilization of ternary complex binding to 40S subunits, and dissociation of 40S and 60S subunits.; Title: strong similarity to eukaryotic initiation factor 3H1 subunit TIF3H1 - Arabidopsis thaliana; cytoplasm; See PMID 11042177; uncharacterized protein 394902 4982494 An08g01790 Aspergillus niger uncharacterized protein XP_001392298.1 393604 D 5061 CDS An08g01800 4982495 join(395310..395339,395396..395585,395664..396460) VIII 1 NT_166524.1 Localization: putative transmembrane protein in the mitochondrial inner membrane.; Similarity: belongs to the mitochondrial carrier family.; Title: strong similarity to hypothetical mitochondrial carrier protein AgPET8 - Ashbya gossypii; See PMID 7941739; uncharacterized protein 396460 4982495 An08g01800 Aspergillus niger uncharacterized protein XP_001392299.1 395310 D 5061 CDS An08g01810 84591588 complement(join(396689..397984,398048..398169,398219..399643,399818..399867,400060..>400409)) VIII 1 NT_166524.1 Remark: the ORF is N-terminally truncated due to end of contig.; Similarity: the N-terminus shows similarity to a broad variety of proline-rich proteins from diverse species.; Title: similarity to S-layer protein - Clostridium thermocellum [truncated ORF]; uncharacterized protein 400409 84591588 An08g01810 Aspergillus niger uncharacterized protein XP_059601156.1 396689 R 5061 CDS An08g01820 4982496 complement(join(<400544..402255,402312..403106,403194..403424)) VIII 1 NT_166524.1 Remark: due to contig end.; Title: similarity to hypothetical potassium channel beta subunit - Rattus norvegicus [truncated ORF]; uncharacterized protein 403424 4982496 An08g01820 Aspergillus niger uncharacterized protein XP_001392300.3 400544 R 5061 CDS An08g01830 84591589 join(403907..403963,404372..404534,404613..404839) VIII 1 NT_166524.1 hypothetical protein 404839 84591589 An08g01830 Aspergillus niger hypothetical protein XP_059601157.1 403907 D 5061 CDS An08g01840 4982499 complement(join(406599..406703,406763..407065,407124..407678)) VIII 1 NT_166524.1 Title: weak similarity to hypothetical transcription factor - Vicia faba; uncharacterized protein 407678 4982499 An08g01840 Aspergillus niger uncharacterized protein XP_001392303.1 406599 R 5061 CDS An08g01850 4982500 join(408172..408315,408356..408691,408762..409173,409228..411636,411687..411961) VIII 1 NT_166524.1 Title: strong similarity to hypothetical DEAD/DEAH box RNA helicase SPCC10H11.01 - Schizosaccharomyces pombe; uncharacterized protein 411961 4982500 An08g01850 Aspergillus niger uncharacterized protein XP_059601158.1 408172 D 5061 CDS An08g01860 4982501 join(414470..415757,415805..415945,415991..416067,416115..416142,416192..416254,416302..416402) VIII 1 NT_166524.1 Remark: SUR1 from Candida albicans complements functional the S. cerevisiae rok1 mutation.; Title: strong similarity to ROK1-suppressor SUR1 -Candida albicans; See PMID 10705369; uncharacterized protein 416402 4982501 An08g01860 Aspergillus niger uncharacterized protein XP_001392305.1 414470 D 5061 CDS An08g01870 4982502 complement(join(416776..417068,417157..417529,417586..417624,417911..418042)) VIII 1 NT_166524.1 Title: weak similarity to hypothetical Pto kinase interactor F28B23.17 - Arabidopsis thaliana; uncharacterized protein 418042 4982502 An08g01870 Aspergillus niger uncharacterized protein XP_059601159.1 416776 R 5061 CDS An08g01880 84591590 join(418552..418576,418617..418735) VIII 1 NT_166524.1 hypothetical protein 418735 84591590 An08g01880 Aspergillus niger hypothetical protein XP_059601160.1 418552 D 5061 CDS An08g01890 4982504 join(419070..419601,419657..419869,419944..420323) VIII 1 NT_166524.1 Title: weak similarity to hypothetical cdk-activating kinase CAK4At - Arabidopsis thaliana; uncharacterized protein 420323 4982504 An08g01890 Aspergillus niger uncharacterized protein XP_059601161.1 419070 D 5061 CDS An08g01900 4982505 join(420712..422296,422347..422476,422769..422845,423039..423178) VIII 1 NT_166524.1 Catalytic activity: Hydrolysis of 1,4-beta-D-xylans so as to remove successive D-xylose residues from the non-reducing termini.; Remark: Also hydrolyses xylobiose.; Title: strong similarity to xylan 1,4-beta-xylosidase - Butyrivibrio fibrisolvens; See PMID 1905520; uncharacterized protein 423178 4982505 An08g01900 Aspergillus niger uncharacterized protein XP_001392309.3 420712 D 5061 CDS An08g01910 4982506 join(423343..423443,423496..423526,423574..423693,423747..423797,423851..423876,423928..424192,424242..424816,424867..425170) VIII 1 NT_166524.1 Catalytic activity: N1-acetylspermine + O(2) + H(2)O <=> N1-acetylspermidine + 3-amino-propanal + H(2)O(2); Cofactor: FAD, Iron.; Title: strong similarity to hypothetical polyamine oxidase PAO - Zea mays; See PMID 9598979; uncharacterized protein 425170 4982506 An08g01910 Aspergillus niger uncharacterized protein XP_059601162.1 423343 D 5061 CDS An08g01920 4982507 complement(join(425381..425467,425531..425578,425940..425955,426007..426830,426889..427588,427638..427738,427788..427871)) VIII 1 NT_166524.1 Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; See PMID 9524126; uncharacterized protein 427871 4982507 An08g01920 Aspergillus niger uncharacterized protein XP_059601163.1 425381 R 5061 CDS An08g01930 4982508 complement(join(428391..428449,428509..428530,428707..429642)) VIII 1 NT_166524.1 Catalytic activity: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP(+) <=> 3-oxoacyl-[acyl-carrier protein] + NADPH; Title: similarity to precursor of 3-oxoacyl-(acyl-carrier-protein) reductase - Cuphea lanceolata; See PMID 1376402; uncharacterized protein 429642 4982508 An08g01930 Aspergillus niger uncharacterized protein XP_059601164.1 428391 R 5061 CDS An08g01940 4982509 complement(join(429782..429836,429868..429892,429952..431182)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical precursor of protein Y4OU - Rhizobium sp.; uncharacterized protein 431182 4982509 An08g01940 Aspergillus niger uncharacterized protein XP_001392313.3 429782 R 5061 CDS An08g01950 4982510 join(431886..431973,432074..432219,432285..432884) VIII 1 NT_166524.1 Title: strong similarity to hypothetical 30.2 KD protein Y4OV - Rhizobium sp.; uncharacterized protein 432884 4982510 An08g01950 Aspergillus niger uncharacterized protein XP_001392314.1 431886 D 5061 CDS An08g01960 4982511 complement(join(433155..433167,433233..433668,433718..434319,434369..434495,434547..434679,434739..434777)) VIII 1 NT_166524.1 Alternative name: S-adenosyl-L-homocysteine hydrolase.; Catalytic activity: S-adenosyl-L-homocysteine + H(2)O <=> adenosine + L-homocysteine; Title: strong similarity to adenosylhomocysteinase -Homo sapiens; uncharacterized protein 434777 4982511 An08g01960 Aspergillus niger uncharacterized protein XP_001392315.1 433155 R 5061 CDS An08g01970 4982512 complement(join(435763..436055,436218..436248,436306..436398,436446..436660,436717..437344)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein encoded by An13g01600 - Aspergillus niger; uncharacterized protein 437344 4982512 An08g01970 Aspergillus niger uncharacterized protein XP_001392316.3 435763 R 5061 CDS An08g01980 4982513 complement(join(437860..438038,438122..438722)) VIII 1 NT_166524.1 Title: weak similarity to hypothetical protein CAC21410.1 - Schizosaccharomyces pombe; uncharacterized protein 438722 4982513 An08g01980 Aspergillus niger uncharacterized protein XP_001392317.1 437860 R 5061 CDS An08g01990 4982514 complement(439697..441253) VIII 1 NT_166524.1 Complex: yeast Prp31p is associated both with the U4/U6 x U5 tri-snRNP and, independently, with the prespliceosome prior to assembly of the tri-snRNP into the splicing complex.; Function: yeast Prp31p is required for the processing of pre-mRNA species both in vivo and in vitro,indicating that the protein is directly involved in the splicing pathway. Prp31p seems to be involved in recruiting the U4/U6 x U5 tri-snRNP to prespliceosome complexes or in stabilizing these interactions.; Phenotype: wild-type PRP31 gene is essential for cell viability.; Similarity: the predicted A. niger protein shows strong similarity to pre-mRNA splicing protein PRP31 from S. cerevisiae and several hypothetical proteins from diverse eucaryotic species.; Title: strong similarity to pre-mRNA splicing protein Prp31 - Saccharomyces cerevisiae; See PMID 9199293; uncharacterized protein 441253 4982514 An08g01990 Aspergillus niger uncharacterized protein XP_001392318.1 439697 R 5061 CDS An08g02000 4982515 join(441669..443453,443509..443757) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein SPBC31F10.11c - Schizosaccharomyces pombe; uncharacterized protein 443757 4982515 An08g02000 Aspergillus niger uncharacterized protein XP_001392319.1 441669 D 5061 CDS An08g02020 4982517 complement(join(444328..445223,445298..445919,445957..445980)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein encoded by An08g02050 - Aspergillus niger; uncharacterized protein 445980 4982517 An08g02020 Aspergillus niger uncharacterized protein XP_059601165.1 444328 R 5061 CDS An08g02030 4982518 join(446639..446696,446750..447285,447452..447521,447578..448599) VIII 1 NT_166524.1 Title: strong similarity to hypothetical Hsp70-like protein CAB91447.2 - Neurospora crassa; uncharacterized protein 448599 4982518 An08g02030 Aspergillus niger uncharacterized protein XP_059601166.1 446639 D 5061 CDS An08g02040 84591591 complement(join(449351..449528,449856..449863)) VIII 1 NT_166524.1 hypothetical protein 449863 84591591 An08g02040 Aspergillus niger hypothetical protein XP_059603892.1 449351 R 5061 CDS An08g02050 4982520 complement(join(451084..451670,451730..451862,451905..452318,452412..452432)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein encoded by An08g02020 - Aspergillus niger; uncharacterized protein 452432 4982520 An08g02050 Aspergillus niger uncharacterized protein XP_059603893.1 451084 R 5061 CDS An08g02060 4982521 join(453201..453761,453922..453994,454052..454395,454449..454555,454598..454787,454838..454946,455008..455231) VIII 1 NT_166524.1 Title: similarity to hypothetical Hsp70-like protein CAB91447.2 - Neurospora crassa; uncharacterized protein 455231 4982521 An08g02060 Aspergillus niger uncharacterized protein XP_059603894.1 453201 D 5061 CDS An08g02070 84591592 complement(join(455984..456061,456207..456335)) VIII 1 NT_166524.1 hypothetical protein 456335 84591592 An08g02070 Aspergillus niger hypothetical protein XP_059603895.1 455984 R 5061 CDS An08g02080 4982523 458255..460381 VIII 1 NT_166524.1 Remark: the similarity to blastp matches is mainly due to repetitive amino acids.; hypothetical protein 460381 4982523 An08g02080 Aspergillus niger hypothetical protein XP_001392326.1 458255 D 5061 CDS An08g02090 4982524 complement(join(461538..463042,463128..463473)) VIII 1 NT_166524.1 Remark: the similarity to blastp matches is due to repetitive amino acids.; hypothetical protein 463473 4982524 An08g02090 Aspergillus niger hypothetical protein XP_001392327.1 461538 R 5061 CDS An08g02100 84591593 join(464875..465091,465184..465222,465254..465321,465379..465646,465714..466054) VIII 1 NT_166524.1 Function: guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.; Remark: a putative sequencing error results in an frameshift.; Similarity: gna-2 of N. crassa belongs to the G-alpha family.; Similarity: the ORF encoded protein shows similarity to many alpha subunits of G proteins.; Title: strong similarity to G protein alpha subunit gna-2 - Neurospora crassa [putative frameshift]; putative frameshift; uncharacterized protein 466054 84591593 An08g02100 Aspergillus niger uncharacterized protein XP_059603896.1 464875 D 5061 CDS An08g02110 4982526 complement(467470..468315) VIII 1 NT_166524.1 Remark: a splice site was detected upstream of the START codon.; Remark: the ORF encoded protein shows similarity to many known and hypothetical zink finger transcription factors.; Title: similarity to factor of late activated T lymphocytes-1 RANTES - Homo sapiens; nucleus; See PMID 10023774; uncharacterized protein 468315 4982526 An08g02110 Aspergillus niger uncharacterized protein XP_001392329.1 467470 R 5061 CDS An08g02120 84591594 complement(join(471760..472018,472166..472276,472472..472723,472764..472817,472848..472906,473016..473052,473322..473542)) VIII 1 NT_166524.1 hypothetical protein 473542 84591594 An08g02120 Aspergillus niger hypothetical protein XP_059603897.1 471760 R 5061 CDS An08g02140 84591595 join(474764..474821,475055..475110) VIII 1 NT_166524.1 Title: questionable ORF; uncharacterized protein 475110 84591595 An08g02140 Aspergillus niger uncharacterized protein XP_059603898.1 474764 D 5061 CDS An08g02150 84591596 join(476029..476067,476155..476172,476211..476294) VIII 1 NT_166524.1 Title: questionable ORF; uncharacterized protein 476294 84591596 An08g02150 Aspergillus niger uncharacterized protein XP_059603899.1 476029 D 5061 CDS An08g02160 84591597 complement(join(478096..478242,478406..478643,478749..478825,478881..479095,479201..479524,479600..479670,479714..479753,479847..479991,480099..480359)) VIII 1 NT_166524.1 hypothetical protein 480359 84591597 An08g02160 Aspergillus niger hypothetical protein XP_059603900.1 478096 R 5061 CDS An08g02170 4982531 join(480998..481135,481175..481618) VIII 1 NT_166524.1 Remark: Similarity to other proteins is based on repetitive sequence motifs.; hypothetical protein 481618 4982531 An08g02170 Aspergillus niger hypothetical protein XP_059603901.1 480998 D 5061 CDS An08g02180 4982532 join(482274..482325,482397..482829,482913..483393) VIII 1 NT_166524.1 Catalytic activity: pyridoxine + NADP(+) <=> pyridoxal + NADPH.; Pathway: PLR of S. pombe is involved in the vitamin B6 metabolism.; Remark: alternate names for the S. pombe pyridoxine 4-dehydrogenase PLR : pyridoxal reductase; pyridoxin dehydrogenase; pyridoxine:NADP+ 4-oxidoreductase.; Title: strong similarity to pyridoxine 4-dehydrogenase PLR - Schizosaccharomyces pombe; See PMID 10438489; See PMID 10705982; uncharacterized protein 483393 4982532 An08g02180 Aspergillus niger uncharacterized protein XP_001392335.1 482274 D 5061 CDS An08g02190 4982533 join(484141..484672,484762..485372) VIII 1 NT_166524.1 Similarity: similarity to many DNA binding proteins.; Title: similarity to hypothetical zinc-finger protein - Schizosaccharomyces pombe; uncharacterized protein 485372 4982533 An08g02190 Aspergillus niger uncharacterized protein XP_001392336.1 484141 D 5061 CDS An08g02200 4982534 complement(join(486734..486863,486922..491306)) VIII 1 NT_166524.1 Function: hrp1 of S. pombe is required for proper chromosome segregation.; Remark: hrp1 of S. pombe is a member of the CHD protein family, characterized by a chromodomain, a Myb-like telobox-related DNA-binding domain and a SNF2-related helicase/ATPase domain.; Title: strong similarity to helicase-related protein hrp1p - Schizosaccharomyces pombe; See PMID 9520266; See PMID 10756203; uncharacterized protein 491306 4982534 An08g02200 Aspergillus niger uncharacterized protein XP_001392337.3 486734 R 5061 CDS An08g02210 4982535 join(<492161..492172,492251..492653,492709..492870,492926..493022,493079..494150,494202..494768) VIII 1 NT_166524.1 Function: the equilibrium between RNase L inhibitor and its RNase target plays a central role in the regulation of mRNA turnover and protein biosynthesis.; Remark: ORF 5'truncated due to end of contig.; Remark: two possible sequencing errors at position 2382 and 2490, giving rise to stopcodons.; Similarity: Rnase L inhibitor is conserved in yeast,mouse, man.; Title: strong similarity to RNase L inhibitor - Homo sapiens [putative sequencing error] [truncated ORF]; putative sequencing error; See PMID 7539425; uncharacterized protein 494768 4982535 An08g02210 Aspergillus niger uncharacterized protein XP_059603902.1 492161 D 5061 CDS An08g02220 4982536 complement(join(<495700..496740,496794..498066,498152..498256)) VIII 1 NT_166524.1 Remark: possible sequencing error at position 5783 leading to frame shift.; Remark: the systematic gene name of PRP40 of S. cerevisiae is YKL012w.; Similarity: the S. cerevisiae Prp40p is about 200 amino acids shorter at C-terminus.; Title: similarity to splicing factor Prp40 -Saccharomyces cerevisiae [putative frameshift]; putative frameshift; See PMID 8622699; See PMID 10978320; uncharacterized protein 498256 4982536 An08g02220 Aspergillus niger uncharacterized protein XP_059603903.1 495700 R 5061 CDS An08g02230 4982537 join(498601..498775,498838..499107,499158..500283,500339..500417,500571..500612) VIII 1 NT_166524.1 Similarity: N-terminal 150 aminoacids show similarity to 200 aminoacids of the C-terminal part of MT2642 of M. tuberculosis.; Title: weak similarity to hypothetical protein MT2642 - Mycobacterium tuberculosis; uncharacterized protein 500612 4982537 An08g02230 Aspergillus niger uncharacterized protein XP_059603904.1 498601 D 5061 CDS An08g02240 4982538 join(501499..501556,501621..501646,501715..502057,502118..502284,502347..502418) VIII 1 NT_166524.1 Similarity: shows similarity to several peroxisomal membrane proteins.; Title: strong similarity to hypothetical peroxisomal organisation and biogenesis protein SPAC3G6.05 -Schizosaccharomyces pombe; uncharacterized protein 502418 4982538 An08g02240 Aspergillus niger uncharacterized protein XP_001392341.3 501499 D 5061 CDS An08g02260 4982539 join(503218..503283,503380..503800,503880..504646) VIII 1 NT_166524.1 Catalytic activity: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.; Pathway: second step in the second phase of glycolysis.; Title: strong similarity to phosphoglycerate kinase pgkA - Aspergillus nidulans; See PMID 3533726; uncharacterized protein 504646 4982539 An08g02260 Aspergillus niger uncharacterized protein XP_001392342.1 503218 D 5061 CDS An08g02270 4982540 complement(join(505346..505382,505543..505657,505788..505902)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein YDR363w-a - Saccharomyces cerevisiae; uncharacterized protein 505902 4982540 An08g02270 Aspergillus niger uncharacterized protein XP_001392343.1 505346 R 5061 CDS An08g02280 4982541 join(506831..506912,506990..507007,507098..507174,507272..507338,507400..508403,508457..509287) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein YKR018c - Saccharomyces cerevisiae; uncharacterized protein 509287 4982541 An08g02280 Aspergillus niger uncharacterized protein XP_001392344.1 506831 D 5061 CDS An08g02290 4982542 join(510207..510586,510702..510793,510845..512031) VIII 1 NT_166524.1 Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353; uncharacterized protein 512031 4982542 An08g02290 Aspergillus niger uncharacterized protein XP_059603905.1 510207 D 5061 CDS An08g02300 84591598 complement(513136..>513972) VIII 1 NT_166524.1 Remark: N-terminally truncated due to contig border.; Similarity: shows good similarity to C-terminus of enniatin synthetase of F. scirpi.; Title: weak similarity to enniatin synthase -Fusarium scirpi [truncated ORF]; uncharacterized protein 513972 84591598 An08g02300 Aspergillus niger uncharacterized protein XP_059603906.1 513136 R 5061 CDS An08g02310 4982544 complement(join(<514101..515540,515590..517208,517257..517704,517786..517917,517976..518355,518412..530724,530778..531080,531178..531594,531748..532251)) VIII 1 NT_166524.1 Function: non-ribosomal peptide synthetases are large, multifunctional protein.; Pathway: production of HC-toxin, a cyclic tetrapeptide.; Remark: C-terminally truncated due to contig border.; Similarity: shows similarity to several known and hypothetical non-ribosomal peptide synthetase of different specificities.; Title: similarity to HC-toxin non-ribosomal peptide synthase HTS1 - Cochliobolus carbonum [truncated ORF]; See PMID 1281482; See PMID 1814363; uncharacterized protein 532251 4982544 An08g02310 Aspergillus niger uncharacterized protein XP_059605409.1 514101 R 5061 CDS An08g02320 84591599 join(535264..535352,535395..535410) VIII 1 NT_166524.1 Title: questionable ORF; uncharacterized protein 535410 84591599 An08g02320 Aspergillus niger uncharacterized protein XP_059605410.1 535264 D 5061 CDS An08g02330 4982546 join(538141..538356,538523..539060,539120..539346,539403..539682,539749..539982,540035..540825,540881..541043,541103..541459,541515..541638,541696..541767,541815..541930,541999..542617,542681..542761,542817..543191,543256..543496) VIII 1 NT_166524.1 Similarity: shows strong similarity to several known and hypothetical ABC-type multidrug transporter proteins with different specificities of different species.; Title: strong similarity to multidrug resistance protein MLP-2 - Rattus norvegicus; See PMID 9614210; uncharacterized protein 543496 4982546 An08g02330 Aspergillus niger uncharacterized protein XP_059605411.1 538141 D 5061 CDS An08g02340 4982547 complement(join(544617..545839,545892..548033,548115..548754)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein SPBC3B9.16c - Schizosaccharomyces pombe; uncharacterized protein 548754 4982547 An08g02340 Aspergillus niger uncharacterized protein XP_001392350.1 544617 R 5061 CDS An08g02350 4982548 complement(join(549134..549945,550013..550080,550166..550245,550323..550406)) VIII 1 NT_166524.1 Function: the uvsC null mutant arrested at an earlier stage than the uvsC114 mutant, before the onset of meiosis; Function: the uvsC null mutant is sensitive to both UV and MMS.; Induction: transcription of uvsC from A. nidulans is induced by methyl-methane sulphonate (MMS).; Title: strong similarity to protein uvsC -Aspergillus nidulans; See PMID 9202381; uncharacterized protein 550406 4982548 An08g02350 Aspergillus niger uncharacterized protein XP_001392351.1 549134 R 5061 CDS An08g02360 4982549 complement(join(551122..551300,551353..551857,552026..552070)) VIII 1 NT_166524.1 hypothetical protein 552070 4982549 An08g02360 Aspergillus niger hypothetical protein XP_059605412.1 551122 R 5061 CDS An08g02370 84591600 complement(join(553381..553655,553729..554023)) VIII 1 NT_166524.1 hypothetical protein 554023 84591600 An08g02370 Aspergillus niger hypothetical protein XP_059605413.1 553381 R 5061 CDS An08g02380 4982551 join(555637..555811,555879..555907,555984..556121,556187..556564) VIII 1 NT_166524.1 hypothetical protein 556564 4982551 An08g02380 Aspergillus niger hypothetical protein XP_001392354.1 555637 D 5061 CDS An08g02390 4982552 join(557217..557652,557682..559396) VIII 1 NT_166524.1 Title: strong similarity to hypothetical conserved protein SPCP1E11.11 - Schizosaccharomyces pombe; uncharacterized protein 559396 4982552 An08g02390 Aspergillus niger uncharacterized protein XP_059605414.1 557217 D 5061 CDS An08g02400 4982553 join(561283..562023,562096..563521,563575..564014) VIII 1 NT_166524.1 Title: similarity to hypothetical protein B16B8.060 - Neurospora crassa; uncharacterized protein 564014 4982553 An08g02400 Aspergillus niger uncharacterized protein XP_001392356.1 561283 D 5061 CDS An08g02410 4982554 join(565227..565233,565552..565578,565780..565933,565996..566863) VIII 1 NT_166524.1 Title: weak similarity to extracellular matrix protein papilin Ppn - Drosophila melanogaster; See PMID 11076767; uncharacterized protein 566863 4982554 An08g02410 Aspergillus niger uncharacterized protein XP_001392357.3 565227 D 5061 CDS An08g02420 4982555 complement(join(568081..568190,568246..568435,568488..568877,568934..569301,569354..569465,569523..570046,570156..570660)) VIII 1 NT_166524.1 hypothetical protein 570660 4982555 An08g02420 Aspergillus niger hypothetical protein XP_059603907.1 568081 R 5061 CDS An08g02430 84591601 join(571330..571372,571786..571868,572296..572787,572933..573004) VIII 1 NT_166524.1 hypothetical protein 573004 84591601 An08g02430 Aspergillus niger hypothetical protein XP_059603908.1 571330 D 5061 CDS An08g02440 4982557 complement(join(573751..574929,574984..575558,575682..576045)) VIII 1 NT_166524.1 Catalytic activity: deoxynucleoside triphosphate + DNA(n) = pyrophosphate + DNA(n+1).; Pathway: purine metabolism; pyrimidine metabolism; DNA polymerase.; Remark: pol lambda has DNA polymerase activity in vitro and shares similar structural organization, including a BRCT domain, helix-loop-helix DNA-binding motifs and polymerase X domain. mRNA expression of pol lambda is highest in testis and fetal liver.; Similarity: belongs to the DNA polymerase IV (family X).; Title: similarity to DNA polymerase lambda POL lambda - Homo sapiens; See PMID 10982892; uncharacterized protein 576045 4982557 An08g02440 Aspergillus niger uncharacterized protein XP_059603909.1 573751 R 5061 CDS An08g02450 4982558 join(576427..576860,576934..577627) VIII 1 NT_166524.1 Remark: ATP10 S. cerevisiae is associated with the mitochondrial membrane but does not co-fractionate either with F1 or with the rutamycin-sensitive F1-F0 complex. These data suggest that the ATP 10 product is not a subunit of the ATPase complex but rather is required for the assembly of the F0 sector of the complex.; Remark: the predicted ORF is approximately 100 amino acids longer.; Title: similarity to mitochondrial protein Atp10 -Saccharomyces cerevisiae; See PMID 2141026; uncharacterized protein 577627 4982558 An08g02450 Aspergillus niger uncharacterized protein XP_001392361.1 576427 D 5061 CDS An08g02460 4982559 complement(join(577950..578453,578538..578651,578716..578781)) VIII 1 NT_166524.1 Remark: GOS1-disrupted cells suggests that Gos1p may play a role in multiple transport steps, specifically ER-Golgi and/or intra-Golgi transport.; Remark: Gos1p S. cerevisiae is a v-SNARE protein and localized to the Golgi compartment and likely homolog of the mammalian protein GOS-28/GS28. Gos1p is a type II membrane protein with characteristic SNARE sequence hallmarks and is functionally a SNARE protein.; Remark: alternate name is YHL031c.; Title: strong similarity to SNARE protein of Golgi compartment Gos1 - Saccharomyces cerevisiae; See PMID 9755865; uncharacterized protein 578781 4982559 An08g02460 Aspergillus niger uncharacterized protein XP_001392362.1 577950 R 5061 CDS An08g02470 4982560 join(579298..579300,579397..579527,579912..580137,580219..580224) VIII 1 NT_166524.1 Remark: hybridization of the cDNA to digests of nuclear DNA suggests that there are 15-17 copies of the L35 gene.; Remark: identical to EST SEQ ID NO:3904 and EST an_3657 from A. niger.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L35 - Rattus norvegicus; See PMID 2322279; See PMID 3426607; 60S ribosomal protein uL29 580224 4982560 An08g02470 Aspergillus niger 60S ribosomal protein uL29 XP_059603910.1 579298 D 5061 CDS An08g02480 4982561 complement(join(580812..581527,581767..582033,582259..582384,582435..582657,582711..583127,583161..583430,583480..583822,583889..584034)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein EAA65820.1 - Aspergillus nidulans; uncharacterized protein 584034 4982561 An08g02480 Aspergillus niger uncharacterized protein XP_059603911.1 580812 R 5061 CDS An08g02490 84591602 complement(join(584641..584764,585300..585519,585734..585820,585903..586144,586319..586360,586449..586578,586680..586977)) VIII 1 NT_166524.1 hypothetical protein 586977 84591602 An08g02490 Aspergillus niger hypothetical protein XP_059603912.1 584641 R 5061 CDS An08g02500 4982563 join(587139..587589,587684..588489,588539..589075) VIII 1 NT_166524.1 Remark: Schizosaccharomyces pombe hst4(+) gene is a member of the SIR2/HST silencing gene family that is defined in organisms ranging from bacteria to humans. Mutant strains show decreased silencing of reporter genes at both telomeres and centromeres. hst4(+) appears to be important for centromere function as well because mutants have elevated chromosome-loss rates and are sensitive to a microtubule-destabilizing drug. Consistent with a role in chromatin structure, Hst4p localizes to the nucleus and appears concentrated in the nucleolus.; Title: strong similarity to silencing gene hst4p -Schizosaccharomyces pombe; See PMID 10512858; uncharacterized protein 589075 4982563 An08g02500 Aspergillus niger uncharacterized protein XP_059603913.1 587139 D 5061 CDS An08g02510 4982564 complement(join(589582..590149,590234..590367,590477..590662)) VIII 1 NT_166524.1 Function: DNA polymerase epsilon p17 subunit p17 of H. sapiens functions in chromosomal DNA replication and probably DNA repair.; Similarity: the predicted ORF shows 56 amino acids long extentions at the N-terminus and at the C-terminus compaired to DNA polymerase epsilon p17 subunit p17 of H. sapiens.; Title: similarity to DNA polymerase epsilon p17 subunit p17 - Homo sapiens; See PMID 10801849; uncharacterized protein 590662 4982564 An08g02510 Aspergillus niger uncharacterized protein XP_001392367.1 589582 R 5061 CDS An08g02520 4982565 complement(join(591434..592942,593005..593099,593153..593165)) VIII 1 NT_166524.1 Remark: the ORF is a putative GTP binding protein.; Remark: the first 93 amino acids are nearly identical to E. nidulans myosin-related protein homolog MlpA.; Title: strong similarity to hypothetical protein YER006w - Saccharomyces cerevisiae; uncharacterized protein 593165 4982565 An08g02520 Aspergillus niger uncharacterized protein XP_001392368.1 591434 R 5061 CDS An08g02530 4982566 join(593604..593703,593766..593787,593850..593959,594095..594576) VIII 1 NT_166524.1 Catalytic activity: glycerol 3-phosphate + H2O = glycerol + phosphate.; Remark: GPP2 has a high specificity for dl-glycerol-3-phosphate, pH optima at 6. 5, and KmG3P in the range of 3-4 mM. The osmotic induction of Gpp2p is blocked in cells that are defective in the HOG-mitogen-activated protein kinase pathway, indicating that GPP2 is a target gene for this osmosensing signal transduction pathway.; Remark: also strong similarity to S. cerevisiae cytosolic glycerol-3-phosphatase encoded by GPP2 gene patent WO9928480-A1.; Title: strong similarity to hyperosmolarity-responsive protein Hor2 - Saccharomyces cerevisiae; See PMID 7500933; See PMID 8662716; See PMID 11058591; uncharacterized protein 594576 4982566 An08g02530 Aspergillus niger uncharacterized protein XP_001392369.1 593604 D 5061 CDS An08g02540 84591603 complement(join(594721..594778,594843..594898,595052..595085,595159..595238,595323..595346,595601..595642,595697..595735)) VIII 1 NT_166524.1 hypothetical protein 595735 84591603 An08g02540 Aspergillus niger hypothetical protein XP_059603914.1 594721 R 5061 CDS An08g02550 84591604 complement(join(596573..596627,596733..596916,597167..597495,597846..597850)) VIII 1 NT_166524.1 hypothetical protein 597850 84591604 An08g02550 Aspergillus niger hypothetical protein XP_059603915.1 596573 R 5061 CDS An08g02560 84591605 join(597885..598003,598074..598166,598251..598403,598485..598580,598784..598955,599077..599171,599361..599577,599867..599983) VIII 1 NT_166524.1 Title: weak similarity to hypothetical threonine dehydratase ilvA - Bacillus halodurans; uncharacterized protein 599983 84591605 An08g02560 Aspergillus niger uncharacterized protein XP_059603916.1 597885 D 5061 CDS An08g02570 84591606 join(600297..600525,600790..600855,600932..601031,601072..601229,601340..601470,601581..601667,601754..601901,602078..602246,602343..602391) VIII 1 NT_166524.1 Title: weak similarity to hypothetical transaminase DR1350 - Deinococcus radiodurans; uncharacterized protein 602391 84591606 An08g02570 Aspergillus niger uncharacterized protein XP_059603917.1 600297 D 5061 CDS An08g02580 4982571 join(604582..604911,604970..606757) VIII 1 NT_166524.1 Remark: during embryogenesis the expression of Hec-Otx becomes restricted to cell lineages fated to give rise to the anterior-most nervous system and the stomodeal component of the primordial pharynx. In hatched larvae Hec-Otx transcripts are detected only in the sensory (brain) vesicle. RA (all-trans retinoic acid) reduces Hec-Otx expression in the tailbud stomodeal pharynx primordium/anterior nervous system cell line but not in the larval sensory vesicle, suggesting that RA regulation of Hec-Otx expression is restricted to pharyngeal tissues throughout embryonic and postlarval development.; Similarity: to unassigned homeobox proteins.; Title: similarity to homeobox protein Hec-Otx -Herdmania curvata; See PMID 11180813; uncharacterized protein 606757 4982571 An08g02580 Aspergillus niger uncharacterized protein XP_001392374.1 604582 D 5061 CDS An08g02590 4982572 join(607524..607658,607745..607963,608038..608763) VIII 1 NT_166524.1 Function: S. cerevisiae PMU1 gene is required in addition to the MAL4 gene for both constitutive maltase synthesis and maltose utilization.; Function: overexpression of S. cerevisiae PMU1/YKL128c reduced the levels of trehalose-6-phosphate in tps2 mutants.; Remark: PMU1 has twice independently been designated in S. cerevisiae and likely describes two different genes,with only PMU1/YKL128c having been characterised on a molecular level.; Title: similarity to trehlose metabolism factor Pmu1 - Saccharomyces cerevisiae; See PMID 7050624; See PMID 8913738; uncharacterized protein 608763 4982572 An08g02590 Aspergillus niger uncharacterized protein XP_001392375.1 607524 D 5061 CDS An08g02600 4982573 complement(609734..611698) VIII 1 NT_166524.1 Remark: the similarity of the predicted A. niger protein and the S. cerevisiae NPL6 protein is restricted to the N-termial half of the protein.; Title: similarity to nuclear localization protein Npl6 - Saccharomyces cerevisiae; See PMID 8514125; uncharacterized protein 611698 4982573 An08g02600 Aspergillus niger uncharacterized protein XP_001392376.3 609734 R 5061 CDS An08g02610 84591607 join(611880..611988,612079..612143,612309..612426,612465..612620,612672..612769) VIII 1 NT_166524.1 hypothetical protein 612769 84591607 An08g02610 Aspergillus niger hypothetical protein XP_059603918.1 611880 D 5061 CDS An08g02620 84591608 join(613603..613614,613646..613990,614082..614217,614350..614420,614561..614803) VIII 1 NT_166524.1 hypothetical protein 614803 84591608 An08g02620 Aspergillus niger hypothetical protein XP_059603919.1 613603 D 5061 CDS An08g02625 84591609 complement(615078..615263) VIII 1 NT_166524.1 hypothetical protein 615263 84591609 An08g02625 Aspergillus niger hypothetical protein XP_059603920.1 615078 R 5061 CDS An08g02630 84591610 join(615310..615663,615743..615794,615919..616013,616082..616278,616340..616492,616632..616801,616851..616910,617023..617147) VIII 1 NT_166524.1 hypothetical protein 617147 84591610 An08g02630 Aspergillus niger hypothetical protein XP_059603921.1 615310 D 5061 CDS An08g02640 84591611 complement(618949..619197) VIII 1 NT_166524.1 hypothetical protein 619197 84591611 An08g02640 Aspergillus niger hypothetical protein XP_059603922.1 618949 R 5061 CDS An08g02650 84591612 complement(join(620557..620652,620745..620793,620885..620932,621015..621078,621173..621383,621573..621711,621801..622004,622103..622266,622362..622391)) VIII 1 NT_166524.1 hypothetical protein 622391 84591612 An08g02650 Aspergillus niger hypothetical protein XP_059603923.1 620557 R 5061 CDS An08g02660 84591613 complement(join(622827..623494,623524..623629)) VIII 1 NT_166524.1 hypothetical protein 623629 84591613 An08g02660 Aspergillus niger hypothetical protein XP_059603924.1 622827 R 5061 CDS An08g02670 4982581 624211..624810 VIII 1 NT_166524.1 Title: strong similarity to EST an_3167 -Aspergillus niger; uncharacterized protein 624810 4982581 An08g02670 Aspergillus niger uncharacterized protein XP_001392384.1 624211 D 5061 CDS An08g02680 4982582 complement(join(626513..628552,628615..629328,629394..629618)) VIII 1 NT_166524.1 Remark: blastp matches are due to repetetive structures.; hypothetical protein 629618 4982582 An08g02680 Aspergillus niger hypothetical protein XP_001392385.1 626513 R 5061 CDS An08g02690 84591614 join(629745..629876,630046..630132) VIII 1 NT_166524.1 Title: questionable ORF; uncharacterized protein 630132 84591614 An08g02690 Aspergillus niger uncharacterized protein XP_059603925.1 629745 D 5061 CDS An08g02700 4982584 complement(join(630670..631670,631742..631769,631905..631962,632027..632103)) VIII 1 NT_166524.1 Catalytic activity: methionine adenosyltransferases convert ATP and L-methionine and H(2)O to phosphate and diphosphate and S-adenosyl-L-methionine.; Function: adenosylmethionine is an important methyl donor in most transmethylation reactions and is also the propylamino donor in the biosynthesis of polyamines.; Phenotype: muations of the human adenosylmethionine can result in an autosomal recessive disorder, the hypermethioninemia.; Title: strong similarity to S-adenosylmethionine synthase eth-1 - Neurospora crassa; See PMID 8849888; uncharacterized protein 632103 4982584 An08g02700 Aspergillus niger uncharacterized protein XP_001392387.1 630670 R 5061 CDS An08g02710 4982585 632809..633687 VIII 1 NT_166524.1 Function: overexpression of S. pombe fet5 suppresses the genetic-defect of nuclear RNA polymerases I-III.; Remark: the predicted A. niger protein contains a leucine zipper region (aa 75-97).; Title: strong similarity to transcription factor fet5p - Schizosaccharomyces pombe; See PMID 9190794; uncharacterized protein 633687 4982585 An08g02710 Aspergillus niger uncharacterized protein XP_001392388.1 632809 D 5061 CDS An08g02720 4982586 complement(join(634638..634665,634759..635372)) VIII 1 NT_166524.1 hypothetical protein 635372 4982586 An08g02720 Aspergillus niger hypothetical protein XP_059603926.1 634638 R 5061 CDS An08g02730 4982587 complement(join(636103..636184,636240..637780,637834..638934)) VIII 1 NT_166524.1 Localization: the A. proteus myosin is found throughout the amoeba cytoplasm but is more concentrated in the ectoplasmic regions.; Similarity: the A. proteus myosin appeares to exist in three different isoforms, with closely related amino acids in the globular head region.; Title: strong similarity to myosin heavy chain -Amoeba proteus; cytoplasm; See PMID 9864850; uncharacterized protein 638934 4982587 An08g02730 Aspergillus niger uncharacterized protein XP_001392390.3 636103 R 5061 CDS An08g02740 84591615 join(639025..639420,639706..639738,639879..639944) VIII 1 NT_166524.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 639944 84591615 An08g02740 Aspergillus niger uncharacterized protein XP_059603927.1 639025 D 5061 CDS An08g02750 84591616 complement(join(640148..640388,640479..640529,640643..640723,640821..640972,641045..641085,641331..641355)) VIII 1 NT_166524.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 641355 84591616 An08g02750 Aspergillus niger uncharacterized protein XP_059603928.1 640148 R 5061 CDS An08g02760 84591617 complement(join(642667..642698,642751..644061,644130..644325)) VIII 1 NT_166524.1 Similarity: the only similarities of the predicted A. niger are due to a N-terminal fungal Zn(2)-Cys(6) binuclear cluster (aa 6-44).; Title: weak similarity to zinc binuclear cluster protein sequence #30 from patent WO200224865-A2 -Unclassified organism; uncharacterized protein 644325 84591617 An08g02760 Aspergillus niger uncharacterized protein XP_059603929.1 642667 R 5061 CDS An08g02770 4982591 complement(join(645042..645654,645712..646231,646301..646604)) VIII 1 NT_166524.1 Complex: S. cerevisiae VMA13 is part of V-ATPase, a multisubunit complex composed of at least eight subunits.; Function: S. cerevisiae VMA13 s essential for activity, but not assembly, of V-ATPase.; Remark: alternative names for S. cerevisiae VMA13 are CLS11 and YPR036W.; Title: strong similarity to vacuolar H(+)-ATPase activator subunit Vma13 - Saccharomyces cerevisiae; vacuole; See PMID 8349704; uncharacterized protein 646604 4982591 An08g02770 Aspergillus niger uncharacterized protein XP_001392394.1 645042 R 5061 CDS An08g02780 4982592 join(647525..648841,648897..649832) VIII 1 NT_166524.1 Remark: the H. sapiens TMF (TATA element modulatory factor) protein binds to the human TATABox in a human immunodeficiency virus 1 TATA element gel-retardation assay.; Similarity: the H. sapiens TMF contains leucine-zipper amino acid motifs (aa 468-486, 471-493,478-500).; Title: strong similarity to transcription factor TMF - Homo sapiens; nucleus; See PMID 1409643; uncharacterized protein 649832 4982592 An08g02780 Aspergillus niger uncharacterized protein XP_001392395.3 647525 D 5061 CDS An08g02790 4982593 complement(join(650088..650138,650210..650539,650603..650725,650787..650915,651007..651032,651086..651143)) VIII 1 NT_166524.1 Remark: the systematic name for S. cerevisiae NAS6 is YGR232W.; Similarity: S. cerevisiae Nas6p shows similarity to a subunit of the 19S proteasome regulatory particle.; Title: strong similarity to hypothetical 19S proteasome interacting protein Nas6 - Saccharomyces cerevisiae; See PMID 9714768; See PMID 10873636; See PMID 11029046; uncharacterized protein 651143 4982593 An08g02790 Aspergillus niger uncharacterized protein XP_001392396.1 650088 R 5061 CDS An08g02800 4982594 651930..652883 VIII 1 NT_166524.1 Function: A. thaliana PRL1 encodes a regulatory WD protein that interacts with ATHKAP2, an alpha-importin nuclear import receptor, and is imported into the nucleus.; Remark: the predicted A. niger protein contains 6 G-beta repeats (PF00400).; Title: strong similarity to nuclear WD protein PRL1 - Arabidopsis thaliana; nucleus; See PMID 9765207; uncharacterized protein 652883 4982594 An08g02800 Aspergillus niger uncharacterized protein XP_001392397.3 651930 D 5061 CDS An08g02810 4982595 complement(join(653308..654076,654274..654786,654837..654946,654985..655824)) VIII 1 NT_166524.1 Complex: the active complex consits of six subunits.; Function: the S. pombe Orc1 protein is component of the origin recognition complex (ORC) that binds origins of replication. It has a role both in chromosomal replication and in mating type transcriptional silencing.; Similarity: the S. pombe Orc1 protein belongs to the ORC1/CDC6/CDC18 family.; Title: strong similarity to origin recognition protein orc1p - Schizosaccharomyces pombe; nucleus; See PMID 7502077; uncharacterized protein 655824 4982595 An08g02810 Aspergillus niger uncharacterized protein XP_059603930.1 653308 R 5061 CDS An08g02820 4982596 join(656785..656807,656855..656915,656951..657282,657413..657542,657617..657841,657906..658489,658581..659541) VIII 1 NT_166524.1 hypothetical protein 659541 4982596 An08g02820 Aspergillus niger hypothetical protein XP_059603931.1 656785 D 5061 CDS An08g02830 4982597 complement(join(659955..660022,660099..660216,660304..660590,660658..660709)) VIII 1 NT_166524.1 Remark: the H. sapiens MM1 was isolated out of a yeast two hybrid screen of human Hela cell cDNA. .; Title: strong similarity to c-myc associated protein MM1 - Homo sapiens; nucleus; See PMID 9792694; uncharacterized protein 660709 4982597 An08g02830 Aspergillus niger uncharacterized protein XP_001392400.1 659955 R 5061 CDS An08g02840 84591618 complement(join(661426..661502,661683..661956)) VIII 1 NT_166524.1 hypothetical protein 661956 84591618 An08g02840 Aspergillus niger hypothetical protein XP_059603932.1 661426 R 5061 CDS An08g02850 4982599 complement(join(662896..663204,663361..663566,663686..663785)) VIII 1 NT_166524.1 Remark: the mutT proteins play an important role in preventing incorporation of mutagenic nucleotides into DNA by hydrolyzing 8-oxo-dGTP.; Title: similarity to hypothetical protein MUTT -Arabidopsis thaliana; uncharacterized protein 663785 4982599 An08g02850 Aspergillus niger uncharacterized protein XP_001392402.1 662896 R 5061 CDS An08g02860 4982600 complement(join(664173..664652,664730..665089,665185..665558,665605..665734,665784..665863,665926..665995)) VIII 1 NT_166524.1 Similarity: E. coli proS belongs to the class II tRNA synthetase family.; Title: strong similarity to cytoplasmic proline--tRNA ligase proS - Escherichia coli; cytoplasm; Catalytic activity: prolyl-tRNA synthetases convert ATP and L-proline and tRNA(Pro) to AMP and diphosphate and L-prolyl-tRNA(Pro).; See PMID 2203971; uncharacterized protein 665995 4982600 An08g02860 Aspergillus niger uncharacterized protein XP_059603933.1 664173 R 5061 CDS An08g02870 4982601 join(666548..667483,667534..668645,668695..669238,669291..670196) VIII 1 NT_166524.1 Function: H. sapiens CCAAT-binding factor (CBF) regulates the expression of the human heat shock gene hsp70.; Title: strong similarity to CCAAT-binding transcription factor CBF - Homo sapiens; See PMID 2247079; uncharacterized protein 670196 4982601 An08g02870 Aspergillus niger uncharacterized protein XP_001392404.3 666548 D 5061 CDS An08g02880 84591619 671632..671940 VIII 1 NT_166524.1 hypothetical protein 671940 84591619 An08g02880 Aspergillus niger hypothetical protein XP_059603934.1 671632 D 5061 CDS An08g02890 84591620 complement(join(672693..672872,672929..673021)) VIII 1 NT_166524.1 hypothetical protein 673021 84591620 An08g02890 Aspergillus niger hypothetical protein XP_059603935.1 672693 R 5061 CDS An08g02900 4982604 join(673058..673267,673354..673496,673552..673678,673728..674651,674716..674796) VIII 1 NT_166524.1 Function: the N. crassa mtr gene product is required for the uptake of neutral aliphatic and aromatic amino acids, as well as toxic analogs such as p-flurophenylalanine or 4-methyltryptophan.; Title: strong similarity to neutral amino acid permease mtr - Neurospora crassa; See PMID 8001794; uncharacterized protein 674796 4982604 An08g02900 Aspergillus niger uncharacterized protein XP_001392407.1 673058 D 5061 CDS An08g02910 4982605 complement(join(675377..675482,675577..677043,677150..677172)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical conserved protein 17E5.150 - Neurospora crassa; uncharacterized protein 677172 4982605 An08g02910 Aspergillus niger uncharacterized protein XP_059603936.1 675377 R 5061 CDS An08g02920 4982606 join(678420..678644,678704..678883,679012..679051,679131..680220,680328..680352) VIII 1 NT_166524.1 Catalytic activity: P450 enzymes catalyse the reaction, RH + reduced flavoprotein + O(2) = ROH + oxidised flavoprotein + H(2)O.; Function: G. fujikuroi P450I is involved in gibberellin biosynthesis.; Function: P450 enzymes usually act as terminal oxidases in multicomponent electron transfer chains in a multitude of biochemical pathways.; Remark: the annotated A. niger protein contains two cytochrom p 450 consensus sequences and displays strong similarity to a broad range of cytochrome P450 enzymes.; Title: strong similarity to cytochrome P450 monooxygenase P450I - Gibberella fujikuroi; See PMID 9501474; See PMID 9917370; uncharacterized protein 680352 4982606 An08g02920 Aspergillus niger uncharacterized protein XP_059603937.1 678420 D 5061 CDS An08g02930 4982607 complement(join(681003..681525,681579..681909,681963..684011,684070..684286,684327..684608)) VIII 1 NT_166524.1 Title: strong similarity to nucleoporin NUP107 -Rattus norvegicus; nucleus; See PMID 8021268; uncharacterized protein 684608 4982607 An08g02930 Aspergillus niger uncharacterized protein XP_059603938.1 681003 R 5061 CDS An08g02940 84591621 join(684987..685199,685316..685488,685588..685903) VIII 1 NT_166524.1 Title: strong similarity to EST an_3396 -Aspergillus niger; uncharacterized protein 685903 84591621 An08g02940 Aspergillus niger uncharacterized protein XP_059603939.1 684987 D 5061 CDS An08g02950 4982609 join(685965..686174,686311..686367) VIII 1 NT_166524.1 Function: S. cerevisiae SMT3 can be conjugated to a number of proteins by ubiquitin ligase E1 and E2 like enzymes.; Remark: the systematic name for SMT3 of S. cerevisiae is YDR510W.; Similarity: S. cerevisiae SMT3 belongs to the SUMO class of ubiquitin like proteins.; Title: strong similarity to ubiquitin like protein Smt3 - Saccharomyces cerevisiae; See PMID 9312010; See PMID 10759568; uncharacterized protein 686367 4982609 An08g02950 Aspergillus niger uncharacterized protein XP_001392412.1 685965 D 5061 CDS An08g02960 4982610 complement(join(687117..687845,688002..688252,688516..688647,688697..688811)) VIII 1 NT_166524.1 Title: weak similarity to protein SEQ ID NO:7168 from patent WO200253728-A2 - Candida albicans; uncharacterized protein 688811 4982610 An08g02960 Aspergillus niger uncharacterized protein XP_059603940.1 687117 R 5061 CDS An08g02970 4982611 join(689573..689741,689791..689798,689848..689961,690010..690153,690209..690591,690644..690893) VIII 1 NT_166524.1 Catalytic activity: S. cerevisiae succinat-CoA ligase catalyze the stepwise synthesis of succinyl-CoA from succinate, CoA, and ATP in the presence of magnesium ion,involving phosphoryl enzyme and enzyme-bound succinyl phosphate as intermediates.; Complex: S. cerevisiae succinat-CoA ligase is an alpha-beta dimer.; Remark: S. cerevisiae succinyl-CoA ligase was shown to utilize ATP but not GTP for succinyl-CoA synthesis.; Title: strong similarity to succinat-CoA ligase alpha chain Lsc1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9874242; uncharacterized protein 690893 4982611 An08g02970 Aspergillus niger uncharacterized protein XP_001392414.3 689573 D 5061 CDS An08g02980 84591622 join(690938..691503,691552..691583,691640..691932,691995..692081) VIII 1 NT_166524.1 Catalytic activity: succinat-CoA ligases converts GTP and succinate and CoA to GDP and succinyl-CoA and phosphate.; Complex: T. vaginalis succinat-CoA ligase is a dimer composed of an alpha and a beta subunit.; Function: the T. vaginalis beta-SCS is involved in fermentative carbohydrate metabolism.; Remark: T. vaginalis succinat-CoA ligase is found in hydrogenosomes, organelles found exclusively in certain anaerobic eukaryotes that lack mitochondria.; Title: strong similarity to succinate-CoA ligase beta chain beta-SCS - Trichomonas vaginalis; See PMID 1400232; uncharacterized protein 692081 84591622 An08g02980 Aspergillus niger uncharacterized protein XP_059603941.1 690938 D 5061 CDS An08g02990 4982613 join(692450..692457,692514..693141) VIII 1 NT_166524.1 Pathway: S. cerevisiae MET14 is a component of the purine metabolism, the selenoamino acid metabolism and the Sulfur metabolism.; Remark: S. cerevisiae MET14 converts ATP and adenylylsulfate to ADP and 3'-phosphoadenylylsulfate.; Similarity: S. pombe orthologue of the S. cerevisiae MET14 is SPAC1782.; Title: strong similarity to adenylylsulfate kinase Met14 - Saccharomyces cerevisiae; See PMID 1654509; uncharacterized protein 693141 4982613 An08g02990 Aspergillus niger uncharacterized protein XP_001392416.1 692450 D 5061 CDS An08g03000 4982614 complement(join(693363..693548,693603..694095,694158..694249,694307..694401,694464..694764)) VIII 1 NT_166524.1 Complex: the S. cerevisiae VMA5 is part of the multisubunit complex of the vacuolar H+-transporting ATPase.; Localization: S. cerevisiae VMA5 is located in the vacuole of the fungal cell.; Pathway: the S. cerevisiae H+-transporting ATPase chain C is part of the oxidative phosphorylation.; Remark: alternative names for S. cerevisiae VMA5 are CSL5, VAT3 and YKL080W.; Remark: the H+-transporting ATPase from S. cerevisiae belongs to a group of enzymes from the plasma membranes of yeast and Neurospora, which are closely related to the H+/K+-transporting ATPases (EC 3. 6. 1. 36).; Title: strong similarity to H+-transporting ATPase chain C Vma5 - Saccharomyces cerevisiae; See PMID 1730668; uncharacterized protein 694764 4982614 An08g03000 Aspergillus niger uncharacterized protein XP_001392417.1 693363 R 5061 CDS An08g03010 4982615 complement(join(695331..695412,695462..695551,695683..695780,695807..696031)) VIII 1 NT_166524.1 Title: strong similarity to EST SEQ ID NO:4179 from patent WO200056762-A2 - Aspergillus niger; uncharacterized protein 696031 4982615 An08g03010 Aspergillus niger uncharacterized protein XP_059603942.1 695331 R 5061 CDS An08g03020 84591623 join(696240..696273,696315..696411,696465..696477) VIII 1 NT_166524.1 Remark: ORF classified questionable due to lenght below 100 aa and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 696477 84591623 An08g03020 Aspergillus niger uncharacterized protein XP_059603943.1 696240 D 5061 CDS An08g03030 4982617 complement(join(696778..697194,697252..697525,697586..697716,697796..697804)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein AF1265 -Archaeoglobus fulgidus; uncharacterized protein 697804 4982617 An08g03030 Aspergillus niger uncharacterized protein XP_059603944.1 696778 R 5061 CDS An08g03040 4982618 complement(join(698350..698418,698664..699388,699500..699662)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein CAA21103.1 - Schizosaccharomyces pombe; uncharacterized protein 699662 4982618 An08g03040 Aspergillus niger uncharacterized protein XP_059603945.1 698350 R 5061 CDS An08g03050 84591624 join(700234..700243,700331..700470) VIII 1 NT_166524.1 hypothetical protein 700470 84591624 An08g03050 Aspergillus niger hypothetical protein XP_059603946.1 700234 D 5061 CDS An08g03060 4982620 join(700678..700810,700868..701511,701563..701885,701934..702073,702120..702568,702617..702729,702789..703386) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein CC0533 - Caulobacter crescentus; uncharacterized protein 703386 4982620 An08g03060 Aspergillus niger uncharacterized protein XP_059603947.1 700678 D 5061 CDS An08g03070 4982621 complement(join(703970..705020,705077..705474)) VIII 1 NT_166524.1 Catalytic activity: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein <=> (6R)-5,10-methylenetetrahydrofolate + NH(3) + dihydrolipoylprotein.; Complex: the T proteins are subunits of the glycine decarboxylase multienzyme complex, which is composed of the four proteins P, T, L, and H.; Function: the S. cerevisea homolog is the T-protein of the glycin cleavage system, which enables growth on glycine as carbon source.; Similarity: the ORF shows strong similarity to expressed sequence tag SEQ ID NO:5306 of patent WO200056762-A2 from Aspergillus oryzae.; Title: strong similarity to glycine decarboxylase subunit T Gcv1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9047339; uncharacterized protein 705474 4982621 An08g03070 Aspergillus niger uncharacterized protein XP_001392424.1 703970 R 5061 CDS An08g03080 4982622 707250..708287 VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein encoded by An08g03120 - Aspergillus niger; uncharacterized protein 708287 4982622 An08g03080 Aspergillus niger uncharacterized protein XP_001392425.1 707250 D 5061 CDS An08g03090 4982623 complement(join(709036..710316,710372..713392)) VIII 1 NT_166524.1 Function: the S. cerevisiae homolog Pmc1p is a calcium-transporting ATPase that pumps Ca2+ into the vacuole. Pmc1p participates in the control of the cytosolic free calcium homeostasis.; Remark: the cellular response to changes in the environmental levels of Ca2+ is mediated by calmodulin and calcineurin which, in turn, modulate the various types of Ca2+ transporters.; Title: strong similarity to calcium-transporting ATPase Pmc1 - Saccharomyces cerevisiae; vacuole; uncharacterized protein 713392 4982623 An08g03090 Aspergillus niger uncharacterized protein XP_059603948.1 709036 R 5061 CDS An08g03100 84591625 join(713922..714149,714279..714464,715041..715292) VIII 1 NT_166524.1 hypothetical protein 715292 84591625 An08g03100 Aspergillus niger hypothetical protein XP_059603949.1 713922 D 5061 CDS An08g03110 84591626 join(716106..716109,716279..716523,716627..716662,716749..716798,716873..717026) VIII 1 NT_166524.1 hypothetical protein 717026 84591626 An08g03110 Aspergillus niger hypothetical protein XP_059603950.1 716106 D 5061 CDS An08g03120 4982626 complement(717422..718396) VIII 1 NT_166524.1 Title: similarity to hypothetical serine/threonine-specific protein kinase SPAC3C7.06c -Schizosaccharomyces pombe; uncharacterized protein 718396 4982626 An08g03120 Aspergillus niger uncharacterized protein XP_001392429.3 717422 R 5061 CDS An08g03130 84591627 join(719126..719203,719275..719356,719592..719648,719760..720160) VIII 1 NT_166524.1 hypothetical protein 720160 84591627 An08g03130 Aspergillus niger hypothetical protein XP_059603951.1 719126 D 5061 CDS An08g03140 84591628 join(722843..723064,723200..723300,723341..723530,723611..723709) VIII 1 NT_166524.1 hypothetical protein 723709 84591628 An08g03140 Aspergillus niger hypothetical protein XP_059603952.1 722843 D 5061 CDS An08g03150 4982629 join(723836..724237,724346..725392,725462..725599) VIII 1 NT_166524.1 Function: the S. cerevisiae homolog Fcy2p is a purine/cytosine permease located in the plasma membrane.; Title: strong similarity to hypothetical purine-cytosine permease Fcy2 - Saccharomyces cerevisiae; plasma membrane; uncharacterized protein 725599 4982629 An08g03150 Aspergillus niger uncharacterized protein XP_059603953.1 723836 D 5061 CDS An08g03160 84591629 complement(join(726715..726888,726983..727237,727362..727595)) VIII 1 NT_166524.1 hypothetical protein 727595 84591629 An08g03160 Aspergillus niger hypothetical protein XP_059603954.1 726715 R 5061 CDS An08g03170 4982631 join(728116..728181,728515..728802,728867..729453,729529..729928) VIII 1 NT_166524.1 Remark: the N. crassa homolog B9I2. 20 is significantly shorter.; Title: similarity to hypothetical protein B9I2.20 -Neurospora crassa; uncharacterized protein 729928 4982631 An08g03170 Aspergillus niger uncharacterized protein XP_001392434.3 728116 D 5061 CDS An08g03180 4982632 join(730860..731054,731346..731441,731533..731933,731997..732105,732167..732322,732399..732611) VIII 1 NT_166524.1 Remark: S. pombe homolog SPBC1289. 02c is hypothetical splicing factor by similarity.; Title: strong similarity to hypothetical splicing factor SPBC1289.02c - Schizosaccharomyces pombe; uncharacterized protein 732611 4982632 An08g03180 Aspergillus niger uncharacterized protein XP_059603955.1 730860 D 5061 CDS An08g03190 4982633 join(733316..733327,733459..733482,733569..733594,733720..733761,733837..733891,733956..734411,734482..734816,734870..735229,735284..735317) VIII 1 NT_166524.1 Complex: tubulin is the major constituent of microtubules. tubulin is a dimer, which consists of an alpha- and beta-chain.; Function: the A. flavus homolog beta-tubulin is the beta-subunit of tubulin, which is a structural protein of the cytoskeleton and is involved in chromosome segregation and nuclear migration.; Title: strong similarity to tubulin beta chain beta-tubulin - Aspergillus flavus; cytoskeleton; uncharacterized protein 735317 4982633 An08g03190 Aspergillus niger uncharacterized protein XP_001392436.1 733316 D 5061 CDS An08g03200 4982634 complement(join(736604..736729,736785..737016,737095..737769,737827..738081,738139..738203,738268..738354)) VIII 1 NT_166524.1 Function: the S. cerevisiae homolog Mep2p is a low capacity, high affinity ammonium permease. Mep2p is involved in pseudohyphae formation in response to nitrogen starvation.; Title: strong similarity to ammonium transport protein Mep2 - Saccharomyces cerevisiae; uncharacterized protein 738354 4982634 An08g03200 Aspergillus niger uncharacterized protein XP_001392437.1 736604 R 5061 CDS An08g03210 84591630 complement(join(738839..739008,739138..739208,739723..739863,739969..740084,740245..740334,740412..740489)) VIII 1 NT_166524.1 hypothetical protein 740489 84591630 An08g03210 Aspergillus niger hypothetical protein XP_059603956.1 738839 R 5061 CDS An08g03220 84591631 join(740942..741044,741084..741187) VIII 1 NT_166524.1 hypothetical protein 741187 84591631 An08g03220 Aspergillus niger hypothetical protein XP_059603957.1 740942 D 5061 CDS An08g03230 84591632 complement(join(741501..741520,741599..741722)) VIII 1 NT_166524.1 hypothetical protein 741722 84591632 An08g03230 Aspergillus niger hypothetical protein XP_059603958.1 741501 R 5061 CDS An08g03240 4982638 join(742060..743870,743924..745689,745753..746222) VIII 1 NT_166524.1 Pathway: Wak1 of S. pombe participates in the stress-activated Wak1-Wis1-Sty1 MAP kinase pathway.; Regulation: Wak1 of S. pombe is regulated by Mcs4.; Remark: cells lacking Mcs4 or Wak1, however, are able to proliferate under stressful conditions and undergo sexual differentiation, suggesting that additional pathway(s) control the Wis1 MAPKK.; Similarity: the predicted A. niger protein shows strong similarity to the MAP kinase kinase kinase Wak1 of S. pombe and related kinases.; Title: strong similarity to MAP kinase kinase kinase wak1p - Schizosaccharomyces pombe; uncharacterized protein 746222 4982638 An08g03240 Aspergillus niger uncharacterized protein XP_059603959.1 742060 D 5061 CDS An08g03250 4982639 complement(join(747592..747658,747722..748212)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein BAB27989.1 - Mus musculus; uncharacterized protein 748212 4982639 An08g03250 Aspergillus niger uncharacterized protein XP_059603960.1 747592 R 5061 CDS An08g03260 4982640 complement(join(749766..749927,749988..750075,750139..750202,750264..750359,750414..750451,750506..750543)) VIII 1 NT_166524.1 Similarity: the ORF shows strong similarity to expressed sequence tag seq id no:4450 of patent WO200056762-A2 from Aspergillus oryzae.; Title: strong similarity to hypothetical mago nashi-like protein - Oryza sativa; uncharacterized protein 750543 4982640 An08g03260 Aspergillus niger uncharacterized protein XP_001392443.3 749766 R 5061 CDS An08g03270 4982641 join(750968..751272,751339..751759,751811..752200,752253..753861,753938..754080) VIII 1 NT_166524.1 Function: the S. cerevisiae homolog Sec26p is the beta chain subunit (beta-COP) of the COPI coatomer complex,which is required for budding from golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.; Title: strong similarity to beta-COP Sec26 -Saccharomyces cerevisiae; intracellular transport vesicles; uncharacterized protein 754080 4982641 An08g03270 Aspergillus niger uncharacterized protein XP_001392444.1 750968 D 5061 CDS An08g03280 4982642 join(755156..755303,755383..756752) VIII 1 NT_166524.1 Function: S. cerevisiae Lcb4p is a sphingoid long chain base (LCB) kinase involved in sphingolipid biosynthesis. Lcb4p can use phytosphingosine,dihydrosphingosine, or sphingosine as substrate.; Remark: the alternative gene name for the S. cerevisiae homolog LCB4 is YOR171c.; Title: strong similarity to sphingoid long chain base kinases Lcb4 - Saccharomyces cerevisiae; uncharacterized protein 756752 4982642 An08g03280 Aspergillus niger uncharacterized protein XP_001392445.1 755156 D 5061 CDS An08g03290 4982643 complement(join(757126..757922,757989..758107,758137..758213)) VIII 1 NT_166524.1 Similarity: the ORF shows strong similarity to expressed sequence tag an_3108 from Aspergillus niger.; Title: similarity to hypothetical protein SPAC9B6.07 - Schizosaccharomyces pombe; uncharacterized protein 758213 4982643 An08g03290 Aspergillus niger uncharacterized protein XP_059603961.1 757126 R 5061 CDS An08g03300 4982644 join(760433..761315,761370..761421,761473..761489,761546..762116,762169..762252,762300..762359,762435..762624,762683..764116,764164..764567,764617..765289) VIII 1 NT_166524.1 Function: the S. cerevisiae homolog gene PDR5 encodes a membrane protein of the ATP-binding-cassette (ABC) superfamily, which is functioning as a drug extrusion pump with multiple pleiotropic substrates.; Induction: expression of S. cerevisiae Pdr5p is regulated by the pleiotropic drug resistance (PDR) network. Transcriptional regulator are Pdr1p, Pdr3p, Pdr7p, and Pdr9p, which also control transcription of several other target genes, many of them also ABC transporter proteins like SNQ2, STE6, PDR10, PDR11 and YOR1.; Title: strong similarity to multidrug resistance protein Pdr5p from patent WO200052144-A1 - Saccharomyces cerevisiae; plasma membrane; uncharacterized protein 765289 4982644 An08g03300 Aspergillus niger uncharacterized protein XP_001392447.3 760433 D 5061 CDS An08g03320 4982646 complement(join(766774..766908,766994..767737,767950..767952)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein SPAPB2B4.07 - Schizosaccharomyces pombe; uncharacterized protein 767952 4982646 An08g03320 Aspergillus niger uncharacterized protein XP_059603962.1 766774 R 5061 CDS An08g03330 84591633 join(768163..768348,768419..768503,768624..768769) VIII 1 NT_166524.1 hypothetical protein 768769 84591633 An08g03330 Aspergillus niger hypothetical protein XP_059603963.1 768163 D 5061 CDS An08g03340 4982648 complement(join(769066..771070,771129..771334)) VIII 1 NT_166524.1 Remark: H. sapiens homolog AAH06108. 1 is significantly longer.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to hypothetical protein AAH06108.1 - Homo sapiens; uncharacterized protein 771334 4982648 An08g03340 Aspergillus niger uncharacterized protein XP_059603964.1 769066 R 5061 CDS An08g03350 84591634 join(771906..772172,772243..772245) VIII 1 NT_166524.1 hypothetical protein 772245 84591634 An08g03350 Aspergillus niger hypothetical protein XP_059603965.1 771906 D 5061 CDS An08g03360 4982650 join(773361..774014,774073..774700,774755..776700) VIII 1 NT_166524.1 Function: S. pombe kin1 affects composition or organization of the cell wall, altering the cell shape when deleted.; Similarity: the S. pombe homolog kin1 is closely related to the KIN1- and KIN2-encoded serine/threonine-specific protein kinases of S. cerevisiae.; Title: strong similarity to protein kinase kin1p -Schizosaccharomyces pombe; uncharacterized protein 776700 4982650 An08g03360 Aspergillus niger uncharacterized protein XP_001392452.1 773361 D 5061 CDS An08g03370 84591635 complement(join(777380..777486,777574..777586,777629..777661)) VIII 1 NT_166524.1 hypothetical protein 777661 84591635 An08g03370 Aspergillus niger hypothetical protein XP_059603966.1 777380 R 5061 CDS An08g03380 4982652 join(778386..778433,778787..779975,780030..780487) VIII 1 NT_166524.1 Catalytic activity: S-adenosyl-L-methionine + histone L-lysine <=> S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine.; Function: the S. pombe homolog Clr4 is a histone H3-specific methyltransferase, known to regulate silencing and switching at the mating-type loci due to remodeling of the chromatin structure. Clr4 methylates preferentially lysine 9 of histone H3 (H3 Lys9).; Title: strong similarity to hypothetical mating-type loci and centromere silencing protein clr4p -Schizosaccharomyces pombe; uncharacterized protein 780487 4982652 An08g03380 Aspergillus niger uncharacterized protein XP_001392454.1 778386 D 5061 CDS An08g03390 4982653 complement(781345..782064) VIII 1 NT_166524.1 Similarity: the similarity is restricted to the N-terminal region of the A. niger protein.; Title: weak similarity to DNA-directed RNA polymerase II largest chain RBP1 - Nosema locustae; uncharacterized protein 782064 4982653 An08g03390 Aspergillus niger uncharacterized protein XP_001392455.3 781345 R 5061 CDS An08g03400 4982654 complement(join(783636..785320,785378..786041,786097..788439,788495..790105)) VIII 1 NT_166524.1 Function: the S. cerevisiae homolog Cch1p is involved in calcium influx and the late stage of the mating process.; Title: strong similarity to calcium channel protein Cch1 - Saccharomyces cerevisiae; uncharacterized protein 790105 4982654 An08g03400 Aspergillus niger uncharacterized protein XP_001392456.1 783636 R 5061 CDS An08g03410 84591636 join(790170..790251,790295..790506,790609..790725) VIII 1 NT_166524.1 hypothetical protein 790725 84591636 An08g03410 Aspergillus niger hypothetical protein XP_059603967.1 790170 D 5061 CDS An08g03420 4982656 complement(join(791211..791763,791907..792472,792549..792599)) VIII 1 NT_166524.1 Similarity: the ORF shows similarity to expressed sequence tag h1c04a1. f1 from Aspergillus nidulans.; Title: similarity to hypothetical protein CG13349 -Drosophila melanogaster; uncharacterized protein 792599 4982656 An08g03420 Aspergillus niger uncharacterized protein XP_001392458.1 791211 R 5061 CDS An08g03430 4982657 join(793112..793231,793515..793850,793957..794109) VIII 1 NT_166524.1 Remark: L6 of S. cerevisiae belongs to the L6E family of ribosomal proteins.; Remark: L6 of S. cerevisiae is also called L9324. 4,YLR448w, or YL16. B.; Similarity: the ORF shows also strong similarity to EST seq id NO:4762 of patent WO200056762-A2 from Aspergillus oryzae.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L6 - Saccharomyces cerevisiae; cytoplasm; See PMID 1390890; 60S ribosomal protein eL6 794109 4982657 An08g03430 Aspergillus niger 60S ribosomal protein eL6 XP_001392459.1 793112 D 5061 CDS An08g03440 4982658 complement(join(795037..795603,795693..796172)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein F49E12.10 - Caenorhabditis elegans; uncharacterized protein 796172 4982658 An08g03440 Aspergillus niger uncharacterized protein XP_001392460.1 795037 R 5061 CDS An08g03450 4982659 complement(join(796810..797177,797214..797640,797699..797830,797894..797935)) VIII 1 NT_166524.1 Function: the S. cerevisiae homolog Tsc10p is necessary and sufficient for catalyzing the NADPH-dependent reduction of 3-ketosphinganine to dihydrosphingosine.; Pathway: S. cerevisiae Tsc10p catalyzes the second step in the synthesis of phytosphingosine.; Remark: an alternative gene name for S. cerevisiae TSC10 is YBR265w.; Title: strong similarity to 3-ketosphinganine reductase Tsc10 - Saccharomyces cerevisiae; uncharacterized protein 797935 4982659 An08g03450 Aspergillus niger uncharacterized protein XP_059603968.1 796810 R 5061 CDS An08g03460 4982660 join(798374..798557,798616..800393) VIII 1 NT_166524.1 Function: S. cerevisiae Sas10p ('Something About Silencing') is able to disrupt silencing and derepresses genes associated with silenced chromatin when overproduced.; Localization: Sas10p is a nuclear protein.; Remark: an alternative gene name for the S. cerevisiae homolog SAS10 is YDL153c.; Title: strong similarity to protein involved in silencing Sas10 - Saccharomyces cerevisiae; nucleus; uncharacterized protein 800393 4982660 An08g03460 Aspergillus niger uncharacterized protein XP_001392462.1 798374 D 5061 CDS An08g03470 4982661 complement(join(800807..801062,801132..801170,801230..801431,801482..801593,801650..801731,801784..801818,801871..802060,802110..802199,802249..802345,802401..802758,802804..802863,803039..803438,803492..803867,804067..804415)) VIII 1 NT_166524.1 Function: the M. musculus homolog Msh5 shows a meiotic defect, leading to male and female sterility in mice.; Similarity: M. musculus Msh5 is a member of the mammalian mismatch repair protein family of MutS and MutL.; Title: strong similarity to DNA mismatch repair gene MSH5 from patent WO9901550-A1 - Mus musculus; nucleus; uncharacterized protein 804415 4982661 An08g03470 Aspergillus niger uncharacterized protein XP_059603969.1 800807 R 5061 CDS An08g03480 4982662 complement(804771..807167) VIII 1 NT_166524.1 Localization: hsp78 from S. cereviesiae is a soluble protein located in the mitochondrial matrix.; Similarity: Hsp78p from S. cereviesiae belongs to the Clp family of ATP-dependent proteases.; Title: strong similarity to mitochondrial heat shock protein Hsp78 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8413229; uncharacterized protein 807167 4982662 An08g03480 Aspergillus niger uncharacterized protein XP_001392464.1 804771 R 5061 CDS An08g03490 4982663 join(807569..807608,807688..807727,807988..808355,808409..808869) VIII 1 NT_166524.1 Function: beta subunit of eukaryotic elongation factor 1 (EF-1) catalyzes the GDP/GTP exchange activity on EF-1 alpha.; Remark: EF-1 from O. cuniculus is C-terminal 100 aa shorter.; Title: similarity to elongation factor 1 beta EF-1 -Oryctolagus cuniculus; cytoplasm; See PMID 8547318; uncharacterized protein 808869 4982663 An08g03490 Aspergillus niger uncharacterized protein XP_059603970.1 807569 D 5061 CDS An08g03493 4982664 join(809258..809313,809433..809703) VIII 1 NT_166524.1 hypothetical protein 809703 4982664 An08g03493 Aspergillus niger hypothetical protein XP_001392466.3 809258 D 5061 CDS An08g03500 84591637 complement(join(810098..810177,810211..810273,810353..810470)) VIII 1 NT_166524.1 hypothetical protein 810470 84591637 An08g03500 Aspergillus niger hypothetical protein XP_059603971.1 810098 R 5061 CDS An08g03510 4982666 join(814553..814618,814682..815007,815360..815409,815564..815664,815843..815880,816015..816126,816160..816254,816627..816873) VIII 1 NT_166524.1 Function: repetitive peptides of the sequence APSASSSSA(P/S)SSSSS(+/-S) are the targets of phosphoglycosylation in L. major.; Similarity: similarity due to N-terminal serine repeats.; Title: weak similarity to proteophosphoglycan ppg1 -Leishmania major; See PMID 10531342; uncharacterized protein 816873 4982666 An08g03510 Aspergillus niger uncharacterized protein XP_059603972.1 814553 D 5061 CDS An08g03520 4982667 join(817018..817410,817471..818490) VIII 1 NT_166524.1 Complex: ubiquitin activating enzyme E1, ubiquitin conjugating enzyme E2 and ubiquitin ligase E3 form a complex with the target protein.; Function: E2 enzymes form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme (E1)-dependent manner,and specifically select target proteins for degradation by the proteasome.; Similarity: shows similarity only in N-terminal half and is C-terminal 200 aa longer than human UBE2.; Title: similarity to ubiquitin conjugating enzyme UBE2 - Homo sapiens [putative frameshift]; cytoplasm; putative frameshift; See PMID 1379239; See PMID 11117256; uncharacterized protein 818490 4982667 An08g03520 Aspergillus niger uncharacterized protein XP_059603973.1 817018 D 5061 CDS An08g03530 4982668 complement(join(819922..819961,820030..821036,821100..824074,824147..824243)) VIII 1 NT_166524.1 Function: suppression of the thermosensitive phenotype of U5 snRNA (U5AI) identifies SSD1 from S. cerevisiae as a general suppressor of splicing mutants.; Similarity: SSD1 from S. cerevisiae is related to the HSP70 superfamily.; Title: strong similarity to protein phosphatase homolog CaSSD1 - Candida albicans; See PMID 9846729; See PMID 10446233; uncharacterized protein 824243 4982668 An08g03530 Aspergillus niger uncharacterized protein XP_001392470.1 819922 R 5061 CDS An08g03540 84591638 join(824697..824704,824758..824856,824925..825042) VIII 1 NT_166524.1 hypothetical protein 825042 84591638 An08g03540 Aspergillus niger hypothetical protein XP_059603974.1 824697 D 5061 CDS An08g03550 4982670 join(828106..828909,828980..829750) VIII 1 NT_166524.1 Title: similarity to hypothetical RNA export mediator like protein CAD21423.1 - Neurospora crassa; uncharacterized protein 829750 4982670 An08g03550 Aspergillus niger uncharacterized protein XP_001392472.1 828106 D 5061 CDS An08g03560 4982671 830857..832503 VIII 1 NT_166524.1 Similarity: similarity due to serin and threonine repeats confined to central region.; Title: weak similarity to mucin MUC2 - Rattus norvegicus; uncharacterized protein 832503 4982671 An08g03560 Aspergillus niger uncharacterized protein XP_001392473.1 830857 D 5061 CDS An08g03570 4982672 complement(join(833291..839835,839909..839993)) VIII 1 NT_166524.1 Similarity: only C-terminal half shows similarity to C-terminal half of MyHC3 C. coturnix.; Title: similarity to slow myosin heavy chain MyHC3 -Coturnix Coturnix; cytoskeleton; See PMID 8663323; uncharacterized protein 839993 4982672 An08g03570 Aspergillus niger uncharacterized protein XP_059603975.1 833291 R 5061 CDS An08g03580 4982673 complement(join(841920..842149,842219..842379,842443..842700,842768..843024)) VIII 1 NT_166524.1 Function: BGT1 from A. fumigatus introduces intrachain 1,6-beta linkages into 1,3-beta-glucan.; Title: strong similarity to 1,3-beta-glucanosyltransferase bgt1 - Aspergillus fumigatus; cell wall; See PMID 9846753; uncharacterized protein 843024 4982673 An08g03580 Aspergillus niger uncharacterized protein XP_001392475.1 841920 R 5061 CDS An08g03590 4982674 join(845070..845267,845405..845612,845695..845882,845944..845961) VIII 1 NT_166524.1 Function: Emp24p from S. cerevisiae is a type I transmembrane protein that is involved in secretory protein transport from the endoplasmic reticulum (ER) to the Golgi complex.; Localization: Emp24p from S. cerevisiae is a component of ER-derived COPII-coated vesicles.; Title: strong similarity to precursor of protein Emp24 - Saccharomyces cerevisiae; intracellular transport vesicles; See PMID 7729411; uncharacterized protein 845961 4982674 An08g03590 Aspergillus niger uncharacterized protein XP_001392476.1 845070 D 5061 CDS An08g03600 4982675 complement(join(847315..847437,847504..847523,847577..847679,847741..847759,847814..847953,848024..848059,848128..848133,848174..848260)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein CAE47874.1/AfA24A6.130c - Aspergillus fumigatus; uncharacterized protein 848260 4982675 An08g03600 Aspergillus niger uncharacterized protein XP_059603976.1 847315 R 5061 CDS An08g03610 4982676 join(849633..849813,849886..851678) VIII 1 NT_166524.1 Function: lysosomal phosphodiesterase that hydrolyzes sphingomyelin to ceramide and phosphocholine.; Similarity: human ASM1 is C-terminally 200 aa shorter.; Title: similarity to acid sphingomyelinase phosphodiesterase ASM1 - Homo sapiens; See PMID 2555181; uncharacterized protein 851678 4982676 An08g03610 Aspergillus niger uncharacterized protein XP_059603977.1 849633 D 5061 CDS An08g03620 4982677 854006..855148 VIII 1 NT_166524.1 Function: BMH2 from S. cerevisiae is essential for pseudohyphal-development MAPK cascade signaling.; Similarity: only C-terminal 100 aa show similarity to BMH2 from S. cerevisiae.; Title: weak similarity to 14-3-3 protein Bmh2 -Saccharomyces cerevisiae; See PMID 9215628; uncharacterized protein 855148 4982677 An08g03620 Aspergillus niger uncharacterized protein XP_001392479.1 854006 D 5061 CDS An08g03630 4982678 856645..857637 VIII 1 NT_166524.1 Similarity: only C-terminal half shows weak similarity to N-terminal part of much longer VRP1 from S. cerevisiae.; Title: weak similarity to verprolin Vrp1 -Saccharomyces cerevisiae; uncharacterized protein 857637 4982678 An08g03630 Aspergillus niger uncharacterized protein XP_059603978.1 856645 D 5061 CDS An08g03640 4982679 complement(join(858179..858473,858546..858896,858955..859772,859829..860023)) VIII 1 NT_166524.1 Function: TOXA of C. carbonum exports the cyclic tetrapeptide HC-toxin, which is responsible for the maize pathogenicity of the fungus.; Function: TOXA of C. carbonum may function in self-protection against the HC-toxin and/or the secretion of HC-toxin into the extracellular milieu.; Remark: the HC-toxin exerts a potent cytostatic effect on plant and animal cells by inhibiting histone deacetylase.; Similarity: TOXA from C. carbonum belongs to the major facilitator superfamily.; Title: strong similarity to HC-toxin efflux pump TOXA - Cochliobolus carbonum; plasma membrane; See PMID 8704997; uncharacterized protein 860023 4982679 An08g03640 Aspergillus niger uncharacterized protein XP_001392481.1 858179 R 5061 CDS An08g03650 10098329 join(860984..861104,861189..861315,861451..861563,861848..861920,861972..863922,863966..864688) VIII 1 NT_166524.1 Function: PUT3 from S. cererevisiae is a positive activator of the proline utilisation pathway.; Remark: similarity is confined to cental 100 aa.; Title: weak similarity to transcription activator Put3 - Saccharomyces cerevisiae; uncharacterized protein 864688 10098329 An08g03650 Aspergillus niger uncharacterized protein XP_003188757.2 860984 D 5061 CDS An08g03660 4982681 join(865108..865213,865339..865864,865948..866260) VIII 1 NT_166524.1 Remark: melusin M. musculus can be regulated by intracellular signals affecting Ca(2+) concentration.; Title: strong similarity to muscle-specific interactor for beta(1) integrin melusin - Mus musculus; See PMID 10506186; uncharacterized protein 866260 4982681 An08g03660 Aspergillus niger uncharacterized protein XP_001392483.1 865108 D 5061 CDS An08g03670 4982682 join(867808..867991,868088..868193,868299..868575,868656..868767,868845..869020,869114..869308,869361..869698,869748..869922) VIII 1 NT_166524.1 Catalytic activity: ATP + ethanolamine <=> ADP + O-phosphoethanolamine; Function: human ethanolamine kinase catalyzes the initial step in the CDP-ethanolamine pathway for phosphatidylethanolamine synthesis.; Title: strong similarity to ethanolamine kinase EKI1 - Homo sapiens; See PMID 9421192; uncharacterized protein 869922 4982682 An08g03670 Aspergillus niger uncharacterized protein XP_059603979.1 867808 D 5061 CDS An08g03680 4982683 join(871681..871923,871981..872009,872073..872404,872452..872565,872613..872938,872999..873385,873434..873781) VIII 1 NT_166524.1 Title: similarity to hypothetical protein CAE47897.1/AfA28D10.030 - Aspergillus fumigatus; uncharacterized protein 873781 4982683 An08g03680 Aspergillus niger uncharacterized protein XP_001392485.1 871681 D 5061 CDS An08g03690 4982684 join(875914..876061,876234..876478,876561..876626,876716..876808) VIII 1 NT_166524.1 Function: ARF-GDP causes COPI dissociation and stimulates the formation of retrograde transport structures that recycle Golgi membrane back to the ER.; Function: human and S. cerevisiae ARF1-GTP, through assembly of COPI to membranes and, possibly, through activation of PLD, is likely to promote the formation and maturation of pre-Golgi intermediates into Golgi elements.; Localization: the cytoplasmic human protein complex ARF1/COPI undergoes regulated assembly and disassembly with membranes of ER and Golgi.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to ADP-ribosylation factor arf1 - Ajellomyces capsulatus; cytoplasm; See PMID 9681627; uncharacterized protein 876808 4982684 An08g03690 Aspergillus niger uncharacterized protein XP_003188741.1 875914 D 5061 CDS An08g03700 4982685 complement(join(877325..877330,877457..877463,877553..878451,878499..878501)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein CAE47899.1/AfA28D10.040c - Aspergillus fumigatus; uncharacterized protein 878501 4982685 An08g03700 Aspergillus niger uncharacterized protein XP_059603980.1 877325 R 5061 CDS An08g03710 4982686 880414..882849 VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein CAD36993.1 - Neurospora crassa; uncharacterized protein 882849 4982686 An08g03710 Aspergillus niger uncharacterized protein XP_001392488.1 880414 D 5061 CDS An08g03720 4982687 complement(join(883120..884143,884188..884278,884326..884733,884790..884877,884934..885122)) VIII 1 NT_166524.1 Title: similarity to fungal ZBC protein sequence #44 from patent WO200224865-A2 - unidentified organism; uncharacterized protein 885122 4982687 An08g03720 Aspergillus niger uncharacterized protein XP_001392489.3 883120 R 5061 CDS An08g03730 4982688 complement(join(885916..886354,886441..886658,886714..887025)) VIII 1 NT_166524.1 Catalytic activity: Gibberellin + 2-oxoglutarate + O(2) <=> 2-beta-hydroxygibberellin + succinate + CO(2).; Remark: closest manual homolog (BLASTP) is PIR:T09683 gibberellin 7-oxidase - Cucurbita maxima (winter squash).; Title: similarity to gibberellin 7-oxidase -Cucurbita maxima; See PMID 9177256; uncharacterized protein 887025 4982688 An08g03730 Aspergillus niger uncharacterized protein XP_001392490.1 885916 R 5061 CDS An08g03740 4982689 complement(join(887742..888270,888356..888927)) VIII 1 NT_166524.1 Catalytic activity: Acyl-[acyl-carrier protein] + NADP(+) <=> trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH.; Function: lovC from A. terreus interacts with LNKS and is necessary for the correct processing of the growing polyketide chain and production of dihydromonacolin L.; Function: lovC from A. terreus is an accessory protein that modulates polyketide synthase activity during lovastatin biosynthesis.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994; uncharacterized protein 888927 4982689 An08g03740 Aspergillus niger uncharacterized protein XP_001392491.1 887742 R 5061 CDS An08g03750 4982690 join(888959..889076,889128..889255,889358..889498,889572..889938,889991..890835,890919..891050) VIII 1 NT_166524.1 Function: FLU1 from C. albicans confers resistance to fluconazole.; Similarity: FLU1 from C. albicans belongs to the Major Facilitator Superfamily.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; plasma membrane; uncharacterized protein 891050 4982690 An08g03750 Aspergillus niger uncharacterized protein XP_059603981.1 888959 D 5061 CDS An08g03760 4982691 complement(join(891394..891432,891486..891521,891564..891998)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein Rv3472 -Mycobacterium tuberculosis; uncharacterized protein 891998 4982691 An08g03760 Aspergillus niger uncharacterized protein XP_059603982.1 891394 R 5061 CDS An08g03770 4982692 893081..894331 VIII 1 NT_166524.1 Function: MUC-type mucins comprise a family of structurally related molecules, which are expressed in epithelia of the body that are in close contact with the milieu.; Title: weak similarity to mucin MUC5AC - Homo sapiens; See PMID 7826332; See PMID 9866714; uncharacterized protein 894331 4982692 An08g03770 Aspergillus niger uncharacterized protein XP_001392494.1 893081 D 5061 CDS An08g03780 4982693 complement(join(894926..895175,895279..895778,895868..896040,896099..896284,896479..896794,896877..896945)) VIII 1 NT_166524.1 Function: it is suggested that Tri11 from F. sporotrichioides encodes a C-15 hydroxylase involved in trichothecene biosynthesis.; Phenotype: disruption of TRI11 of F. sporotrichioides results in accumulation of isotrichodermin, a trichothecene pathway intermediate.; Remark: TRI11 of F. sporotrichioides defines a new cytochrome P-450 gene family, designated CYP65A1.; Title: strong similarity to cytochrome P450 monooxygenase TRI11 - Fusarium sporotrichioides; See PMID 9435078; uncharacterized protein 896945 4982693 An08g03780 Aspergillus niger uncharacterized protein XP_059603983.1 894926 R 5061 CDS An08g03790 4982694 join(897493..898132,898199..898837,898914..901862,901920..904104,904165..905054,905103..906680,906740..908676) VIII 1 NT_166524.1 Function: like fatty acids, polyketides are assembled by successive decarboxylative condensations of simple precursors.; Function: many polyketides are antibiotics.; Function: polyketide synthases catalyze the assembly of complex natural products from simple precursors such as propionyl-CoA and methylmalonyl-CoA in a biosynthetic process that closely parallels fatty acid biosynthesis.; Function: whereas the intermediates in fatty acid biosynthesis are fully reduced to generate unfunctionalized alkyl chains, the intermediates in polyketide biosynthesis may be only partially processed, giving rise to complex patterns of functional groups.; Remark: polyketide synthases are commercially valuable enzyme.; Title: strong similarity to lovastatin nonaketide synthase lovB - Aspergillus terreus; See PMID 10872449; uncharacterized protein 908676 4982694 An08g03790 Aspergillus niger uncharacterized protein XP_059603984.1 897493 D 5061 CDS An08g03800 84591639 <908873..909532 VIII 1 NT_166524.1 Remark: n-terminal truncated ORF due the end of contig.; Similarity: Protein is also similar to probable component of a peptide synthetase hetM protein - Anabaena sp. (strain PCC 7120); Title: similarity to saframycin Mx1 synthase safA -Myxococcus xanthus [truncated ORF]; See PMID 8157596; See PMID 8936303; uncharacterized protein 909532 84591639 An08g03800 Aspergillus niger uncharacterized protein XP_059601167.1 908873 D 5061 CDS An08g03810 4982696 complement(join(910254..910345,910390..911197)) VIII 1 NT_166524.1 Similarity: shows strong similarity to C-terminal two-thirds of An02g00870.; Title: similarity to hypothetical protein encoded by An02g00870 - Aspergillus niger; uncharacterized protein 911197 4982696 An08g03810 Aspergillus niger uncharacterized protein XP_001392498.3 910254 R 5061 CDS An08g03820 4982697 complement(912281..913327) VIII 1 NT_166524.1 Similarity: Product is also similar (E-val. 9e-95) to toxD of Cochliobolus carbonum, its role in synthesis of peptide antibiotics is still not yet clear.; Title: strong similarity to enoyl reductase of the lovastatin biosynthesis lovC - Aspergillus terreus; See PMID 10334994; uncharacterized protein 913327 4982697 An08g03820 Aspergillus niger uncharacterized protein XP_001392499.1 912281 R 5061 CDS An08g03830 4982698 join(913852..914266,914323..914897) VIII 1 NT_166524.1 Catalytic activity: cinnamyl alcohol + NADP(+) <=> cinnamaldehyde + NADPH-.; Pathway: lignin biosynthesis.; Remark: Eucalyptus gunnii=cider tree.; Remark: catalyzes the reversible oxidation of cinnamyl alcohol to cinnamacetaldehyde with the concomitant reduction of NADP.; Title: strong similarity to cinnamyl-alcohol dehydrogenase CAD1 - Eucalyptus gunnii; See PMID 9526508; uncharacterized protein 914897 4982698 An08g03830 Aspergillus niger uncharacterized protein XP_001392500.1 913852 D 5061 CDS An08g03840 4982699 complement(915845..916960) VIII 1 NT_166524.1 Remark: The qa-4 gene of Neurospora crassa encodes 3-dehydroshikimate dehydratase, which catalyzes the third step of the quinic acid (qa) catabolic pathway.; Title: strong similarity to 3-dehydroshikimate dehydratase qa-4 - Neurospora crassa; See PMID 6241580; See PMID 1825499; uncharacterized protein 916960 4982699 An08g03840 Aspergillus niger uncharacterized protein XP_001392501.1 915845 R 5061 CDS An08g03850 4982700 complement(join(917816..918898,918953..919489)) VIII 1 NT_166524.1 Remark: QutD gene encodes an essential component of a permease required for transport of quinate ion into mycelium at pH 6. 5.; Title: strong similarity to quinate transport protein qutD - Aspergillus nidulans; See PMID 3049934; See PMID 2835177; See PMID 2976880; uncharacterized protein 919489 4982700 An08g03850 Aspergillus niger uncharacterized protein XP_001392502.1 917816 R 5061 CDS An08g03860 4982702 complement(join(921481..921603,921780..921923)) VIII 1 NT_166524.1 hypothetical protein 921923 4982702 An08g03860 Aspergillus niger hypothetical protein XP_059601168.1 921481 R 5061 CDS An08g03870 84591640 complement(921944..924571) VIII 1 NT_166524.1 Remark: QUTA is a positively acting regulatory protein that regulates the expression of the eight genes comprising the quinic acid utilization gene (qut) gene cluster in Aspergillus nidulans. Genetic evidence suggests that the activity of the native QUTA transcription activator protein is negated by the action of the QUTR transcription repressor protein. It has been proposed that the QUTA protein is composed of two domains that are related to the N-terminal two domains-dehydroquinate (DHQ) synthase and 5-enolpyruvyl shikimate-3-phosphate (EPSP) synthase-of the pentadomain AROM protein.; Title: strong similarity to regulator protein qutA -Aspergillus nidulans; See PMID 3313276; See PMID 8581174; See PMID 8704987; uncharacterized protein 924571 84591640 An08g03870 Aspergillus niger uncharacterized protein XP_059601169.1 921944 R 5061 CDS An08g03880 4982703 926362..928887 VIII 1 NT_166524.1 Function: Mutant phenotypes imply that the QutR protein plays a key role in signal recognition and transduction.; Function: Mutations in the qutR gene alter QutR function such that the transcription of the qut gene cluster is permanently on (constitutive phenotype) or is insensitive to the presence of quinate (super-repressed phenotype).; Remark: QutR-encoded transcription-repressing protein is a multi-domain repressor protein active in the signal-transduction pathway that regulates transcription of the quinic acid utilization (qut) gene cluster in Aspergillus nidulans.; Title: strong similarity to hypothetical negative-acting regulatory protein qutR - Aspergillus nidulans; See PMID 8704987; See PMID 10926843; See PMID 1544567; uncharacterized protein 928887 4982703 An08g03880 Aspergillus niger uncharacterized protein XP_001392505.3 926362 D 5061 CDS An08g03890 4982704 complement(join(930006..930051,930253..930562,930713..930962)) VIII 1 NT_166524.1 Catalytic activity: the superoxid Cu/Zn dismutase converts 2 peroxide radical and 2 H(+) to O(2) and H(2)O(2).; Remark: alternate names for the superoxid Cu/Zn dismutase is erythrocuprein, hemocuprein or cytocuprein.; Remark: superoxid Cu/Zn dismutase from most eucaryotes contain both copper and zinc; those from mitochondria and most procaryotes contain manganese or iron.; Title: strong similarity to hypothetical superoxid Cu/Zn dismutase B24P7.320 - Neurospora crassa; uncharacterized protein 930962 4982704 An08g03890 Aspergillus niger uncharacterized protein XP_001392506.3 930006 R 5061 CDS An08g03900 4982705 join(933220..933394,933453..933559,933615..934150,934202..934655,934710..934865) VIII 1 NT_166524.1 Catalytic activity: the C. porcellus FMO2 converts N, N-dimethylaniline and NADPH and O(2) to N,N-dimethylaniline N-oxide and NADP(+) and H(2)O.; Function: FMO2 belongs to the oxidoreductases of the lung microsomes, who need FAD as a cofactor.; Remark: a mutation in the FMO2 gene causes the human inheritable disorder trimethylaminuria.; Title: similarity to dimethylanilin monooxygenase FMO2 - Cavia porcellus; See PMID 1306120; uncharacterized protein 934865 4982705 An08g03900 Aspergillus niger uncharacterized protein XP_001392507.3 933220 D 5061 CDS An08g03910 4982706 join(935469..935487,935564..935741,935819..936012,936074..936336) VIII 1 NT_166524.1 Remark: the R. norvegicus L10a protein is a subunit of the 60S ribosomal complex.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L10a - Rattus norvegicus; cytoplasm; See PMID 8607874; 60S ribosomal protein uL1 936336 4982706 An08g03910 Aspergillus niger 60S ribosomal protein uL1 XP_001392508.1 935469 D 5061 CDS An08g03920 4982707 complement(join(936508..936665,936799..938005)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein CAE47894.1 - Aspergillus fumigatus; uncharacterized protein 938005 4982707 An08g03920 Aspergillus niger uncharacterized protein XP_001392509.3 936508 R 5061 CDS An08g03930 4982708 join(938376..938492,938551..938645,938748..938999,939105..939795) VIII 1 NT_166524.1 Remark: the encoded protein shows similarities to Vpr1 from S. cerevisiae only at the very N- and C-terminal sequences.; Title: weak similarity to verprolin Vrp1 -Saccharomyces cerevisiae; See PMID 7968536; uncharacterized protein 939795 4982708 An08g03930 Aspergillus niger uncharacterized protein XP_059601170.1 938376 D 5061 CDS An08g03940 4982709 join(940538..940562,940649..940920) VIII 1 NT_166524.1 Title: similarity to hypothetical splicing factor -Schizosaccharomyces pombe; uncharacterized protein 940920 4982709 An08g03940 Aspergillus niger uncharacterized protein XP_001392511.1 940538 D 5061 CDS An08g03950 4982710 943304..944512 VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein CAE47900.1/AfA28D10.050 - Aspergillus fumigatus; uncharacterized protein 944512 4982710 An08g03950 Aspergillus niger uncharacterized protein XP_001392512.1 943304 D 5061 CDS An08g03960 4982711 complement(join(946051..946123,946199..946263,946321..946814,946913..947025,947156..947175)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical edoplasmic reticulum associated protein - Schizosaccharomyces pombe; See PMID 9414319; uncharacterized protein 947175 4982711 An08g03960 Aspergillus niger uncharacterized protein XP_001392513.3 946051 R 5061 CDS An08g03970 4982712 complement(948947..950137) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein CAE47902.1 - Aspergillus fumigatus; uncharacterized protein 950137 4982712 An08g03970 Aspergillus niger uncharacterized protein XP_001392514.1 948947 R 5061 CDS An08g03980 4982713 join(952854..952889,952981..953084,953139..953308,953367..953401,953467..953763,953831..954454) VIII 1 NT_166524.1 Complex: the C. fasciculata IUNH forms a homotetramer.; Function: the C. fasciculata IUNH catalyses the hydrolysis of all of the commonly occuring purine and pyrimindine nucleosides into ribose and the associated base, but has a preference for inosine and uridine as substrates.; Remark: the IUNH is important for parasitic protozoans, which are deficient in de novo synthsis of purines, to salvage the host purine nucleosides.; Title: strong similarity to inosine-uridine nucleosid hydrolase IUNH - Crithidia fasciculata; See PMID 8634237; uncharacterized protein 954454 4982713 An08g03980 Aspergillus niger uncharacterized protein XP_001392515.1 952854 D 5061 CDS An08g03990 84591641 complement(join(954520..954586,954676..954908,954958..955033,955087..955517)) VIII 1 NT_166524.1 hypothetical protein 955517 84591641 An08g03990 Aspergillus niger hypothetical protein XP_059601171.1 954520 R 5061 CDS An08g04000 4982715 join(957035..957622,957693..958268) VIII 1 NT_166524.1 Title: strong similarity to hypothetical transcription factor CAE47904.1 - Aspergillus fumigatus; uncharacterized protein 958268 4982715 An08g04000 Aspergillus niger uncharacterized protein XP_001392517.1 957035 D 5061 CDS An08g04015 4982716 960537..960872 VIII 1 NT_166524.1 hypothetical protein 960872 4982716 An08g04015 Aspergillus niger hypothetical protein XP_001392518.1 960537 D 5061 CDS An08g04030 4982718 join(962056..962090,962189..962536,962608..963292,963384..964646) VIII 1 NT_166524.1 Function: the E. coli Hbp interacts with hemoglobin,degrades it and subsequently binds the released heme.; Remark: pathogenic E. coli strains are capable of using hemoglobin as an iron source.; Remark: the similarity of the predicted A. niger protein to the Hbp protein is restricted to the N-terminal part of the A. niger protein (aa 7-280).; Similarity: the E. coli Hbp belongs to the so-called IgA1 protease-like proteins, as indicated by the kinetics of its membrane transfer and DNA sequence similarity.; Title: weak similarity to hemoglobin protease Hbp -Escherichia coli; See PMID 9743528; uncharacterized protein 964646 4982718 An08g04030 Aspergillus niger uncharacterized protein XP_059601172.1 962056 D 5061 CDS An08g04040 4982719 complement(join(964840..965231,965285..965805,965857..966094,966152..966492,966547..966602)) VIII 1 NT_166524.1 Function: qutD of A. nidulans is required for the transport of quinate into the mycelium.; Similarity: qutD of A. nidulans belongs to the sugar transporter family.; Title: strong similarity to quinate transport protein qutD - Aspergillus nidulans; See PMID 2835177; See PMID 2976880; uncharacterized protein 966602 4982719 An08g04040 Aspergillus niger uncharacterized protein XP_001392520.1 964840 R 5061 CDS An08g04050 84591642 complement(join(967912..969071,969215..969296)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein CAE47908.1/AfA28D10.093c - Aspergillus fumigatus; uncharacterized protein 969296 84591642 An08g04050 Aspergillus niger uncharacterized protein XP_059601173.1 967912 R 5061 CDS An08g04060 4982721 join(970205..970373,970434..970850,970928..971780,971856..972108,972193..972210) VIII 1 NT_166524.1 Title: strong similarity to hypothetical transcription factor IIIc-like protein CAE47909.1 -Aspergillus fumigatus; uncharacterized protein 972210 4982721 An08g04060 Aspergillus niger uncharacterized protein XP_059601174.1 970205 D 5061 CDS An08g04070 4982722 complement(join(973128..973181,973430..973719,973928..974045)) VIII 1 NT_166524.1 Complex: the MOM22 protein is part of receptor complex in the mitochondrial outer membrane, which consists of at least seven different proteins.; Function: the receptor complex in the mitochondrial outer membrane is responsible for the recognition and translocation of cytosolically synthesized preproteins.; Title: strong similarity to mitochondrial receptor complex chain MOM22 - Neurospora crassa; localisation:mitochondrion; See PMID 8348615; uncharacterized protein 974045 4982722 An08g04070 Aspergillus niger uncharacterized protein XP_001392523.1 973128 R 5061 CDS An08g04080 4982723 complement(join(974458..976104,976192..976296)) VIII 1 NT_166524.1 Function: MPP of N. crassa is a mitochondrial processing peptidase, which releases the N-terminal transit peptides from precursor proteins imported into the mitochondrion.; Remark: E. C. number has been changed from 3. 4. 99. 41 to 3. 4. 24. 64.; Title: strong similarity to mitochondrial processing peptidase alpha chain MPP - Neurospora crassa; localisation:mitochondrion; See PMID 2141023; uncharacterized protein 976296 4982723 An08g04080 Aspergillus niger uncharacterized protein XP_001392524.1 974458 R 5061 CDS An08g04090 4982724 complement(join(976836..978695,978787..979008)) VIII 1 NT_166524.1 Catalytic activity: acsA of S. meliloti catalyzes the reaction of ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA.; Function: acsA of S. meliloti activates acetoacetate to acetoacetyl-CoA.; Function: acsA of S. meliloti is involved in poly-3-hydroxybutyrate degradation.; Similarity: acsA of S. meliloti belongs to the ATP-dependent AMP-binding enzyme family.; Title: strong similarity to acetoacetyl-CoA synthase acsA - Sinorhizobium meliloti; See PMID 10735852; uncharacterized protein 979008 4982724 An08g04090 Aspergillus niger uncharacterized protein XP_001392525.1 976836 R 5061 CDS An08g04100 4982725 980848..982878 VIII 1 NT_166524.1 Catalytic activity: LCB2 of S. cerevisiae catalyzes the reaction of palmitoyl-CoA + l-serine = CoA + 3-dehydro-d-sphinganine + CO(2).; Complex: LBC1 and LBC2 may encode subunits of the enzyme.; Pathway: LCB2 of S. cerevisiae catalyzes the first step in the biosynthesis of the long-chain base component of sphingolipids.; Remark: SCS1, YDR062W, YD9609. 16 and D4246 are alternative names for LCB2.; Remark: a splice site was detected upstream of the START codon.; Similarity: LCB2 of S. cerevisiae belongs to class-II of pyridoxal-phosphate-dependent aminotransferases.; Title: strong similarity to serine palmitoyltransferase 2 Lcb2 - Saccharomyces cerevisiae; See PMID 8058731; uncharacterized protein 982878 4982725 An08g04100 Aspergillus niger uncharacterized protein XP_001392526.1 980848 D 5061 CDS An08g04110 4982726 complement(join(984366..985188,985276..985661)) VIII 1 NT_166524.1 Title: similarity to hypothetical membrane protein YDR352w - Saccharomyces cerevisiae; uncharacterized protein 985661 4982726 An08g04110 Aspergillus niger uncharacterized protein XP_059601175.1 984366 R 5061 CDS An08g04120 4982727 complement(join(988120..988567,988652..989007)) VIII 1 NT_166524.1 Similarity: the ORF also shows strong similarity to the 5' end of the cDNA clone 2094 of A. niger.; Title: similarity to hypothetical mold-specific protein MS8 - Ajellomyces capsulatus; uncharacterized protein 989007 4982727 An08g04120 Aspergillus niger uncharacterized protein XP_059601176.1 988120 R 5061 CDS An08g04130 4982728 complement(join(989953..991074,991131..991273,991322..991685,991731..991804,991853..992005,992134..992499,992577..992604)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein SPBC1706.01 - Schizosaccharomyces pombe; uncharacterized protein 992604 4982728 An08g04130 Aspergillus niger uncharacterized protein XP_059601177.1 989953 R 5061 CDS An08g04140 4982729 993995..995935 VIII 1 NT_166524.1 Function: par1 of C. elegans is required for the first asymmetric cleavage in embryogenesis.; Remark: the similarity of the ORF encoded protein to par1 is restricted to the kinase domain.; Similarity: the ORF encoded protein also shows similarity to other kinases.; Title: similarity to serine/threonine kinase par-1 -Caenorhabditis elegans; See PMID 7758115; uncharacterized protein 995935 4982729 An08g04140 Aspergillus niger uncharacterized protein XP_059601178.1 993995 D 5061 CDS An08g04150 4982730 complement(join(996917..997550,997648..997967)) VIII 1 NT_166524.1 Remark: YNL284C is the systematic name for MRPL10 of S. cerevisiae.; Similarity: MRPL10 of S. cerevisiae shows similarity to bacterial ribosomal L15 proteins.; Title: similarity to mitochondrial ribosomal protein of the large subunit L15 Mrpl10 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 2060626; mitochondrial 54S ribosomal protein uL15m 997967 4982730 An08g04150 Aspergillus niger mitochondrial 54S ribosomal protein uL15m XP_001392531.1 996917 R 5061 CDS An08g04160 4982731 complement(join(998829..999985,1000036..1000309,1000363..1000848)) VIII 1 NT_166524.1 Title: similarity to hypothetical CLG1 cyclin clg1 -Ajellomyces capsulatus; uncharacterized protein 1000848 4982731 An08g04160 Aspergillus niger uncharacterized protein XP_001392532.1 998829 R 5061 CDS An08g04170 84591643 join(1000866..1000882,1000930..1001026,1001132..1001260) VIII 1 NT_166524.1 hypothetical protein 1001260 84591643 An08g04170 Aspergillus niger hypothetical protein XP_059601179.1 1000866 D 5061 CDS An08g04180 84591644 join(1001660..1001740,1001810..1001870,1002680..1002766,1002920..1003157,1003235..1003342,1003429..>1003505) VIII 1 NT_166524.1 Remark: the ORF encoded protein is N-terminally truncated due to the contig border.; hypothetical protein [truncated ORF] 1003505 84591644 An08g04180 Aspergillus niger hypothetical protein [truncated ORF] XP_059601180.1 1001660 D 5061 CDS An08g04190 84591645 complement(join(<1003766..1003921,1004216..1004651,1004724..1004972,1005526..1005644,1005731..1005800,1005936..1005954)) VIII 1 NT_166524.1 Remark: the ORF encoded protein is C-terminally truncated due to the contig border.; hypothetical protein [truncated ORF] 1005954 84591645 An08g04190 Aspergillus niger hypothetical protein [truncated ORF] XP_059601181.1 1003766 R 5061 CDS An08g04200 84591646 join(1006031..1006262,1006360..1006526,1006566..1006803,1006957..1007039) VIII 1 NT_166524.1 hypothetical protein 1007039 84591646 An08g04200 Aspergillus niger hypothetical protein XP_059601182.1 1006031 D 5061 CDS An08g04210 84591647 complement(join(1007758..1007813,1007866..1008041,1008127..1008296,1008785..1008836,1008888..1008957,1009013..1009119,1009251..1009328,1009451..1009582,1009734..1009805,1009931..1010029,1010075..1010211)) VIII 1 NT_166524.1 hypothetical protein 1010211 84591647 An08g04210 Aspergillus niger hypothetical protein XP_059601183.1 1007758 R 5061 CDS An08g04220 84591648 join(1010558..1010563,1010622..1010827,1010897..1011204,1011285..1011409) VIII 1 NT_166524.1 hypothetical protein 1011409 84591648 An08g04220 Aspergillus niger hypothetical protein XP_059601184.1 1010558 D 5061 CDS An08g04230 84591649 complement(join(1014160..1014171,1014258..1014284,1014331..1014365,1014407..1014424,1014494..1014629,1014712..1014762)) VIII 1 NT_166524.1 hypothetical protein 1014762 84591649 An08g04230 Aspergillus niger hypothetical protein XP_059601185.1 1014160 R 5061 CDS An08g04235 84591650 complement(join(1015300..1015686,1015979..1016116)) VIII 1 NT_166524.1 hypothetical protein 1016116 84591650 An08g04235 Aspergillus niger hypothetical protein XP_059601186.1 1015300 R 5061 CDS An08g04240 4982740 join(1017556..1017877,1017958..1018296,1018349..1019317,1019380..1019453) VIII 1 NT_166524.1 Catalytic activity: NADH + ubiquinone = NAD(+) + ubiquinol; Function: NDH2 of Y. lipolytica is the alternative protein for respiratory chain complex I, that does not translocate protons across the inner mitochondrial membrane.; Remark: the alternative NADH:ubiquinone reductase of Y. lipolytica is in contrast to the proteins of S. cerevisiae, Neurospora crassa and green plants probably not binding NADH synthesized in the mitochondrial matrix, but from external origin, as known for common complex I proteins.; Title: strong similarity to alternative NADH:ubiquinone reductase NDH2 - Yarrowia lipolytica; See PMID 10381390; uncharacterized protein 1019453 4982740 An08g04240 Aspergillus niger uncharacterized protein XP_001392541.3 1017556 D 5061 CDS An08g04250 4982741 complement(join(1020627..1021069,1021125..1023140,1023205..1023505)) VIII 1 NT_166524.1 Title: strong similarity to dynamin-related protein msp1p - Schizosaccharomyces pombe; See PMID 9790976; See PMID 10547374; uncharacterized protein 1023505 4982741 An08g04250 Aspergillus niger uncharacterized protein XP_001392542.1 1020627 R 5061 CDS An08g04260 4982742 join(1024136..1024150,1024215..1024310,1024430..1025162,1025223..1025503) VIII 1 NT_166524.1 Title: similarity to hypothetical protein YNL191w -Saccharomyces cerevisiae; uncharacterized protein 1025503 4982742 An08g04260 Aspergillus niger uncharacterized protein XP_001392543.1 1024136 D 5061 CDS An08g04270 4982743 complement(1025906..1027096) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein CAD70845.1 - Neurospora crassa; uncharacterized protein 1027096 4982743 An08g04270 Aspergillus niger uncharacterized protein XP_001392544.1 1025906 R 5061 CDS An08g04280 4982744 complement(join(1028362..1028721,1028782..1029429,1029487..1029591,1029673..1030053)) VIII 1 NT_166524.1 Remark: also similarity to oligouridylate binding protein ubp1; Nicotiana plumbaginifolia; Title: similarity to polyadenylated RNA-binding protein Pub1 - Saccharomyces cerevisiae; See PMID 10943833; See PMID 8413213; uncharacterized protein 1030053 4982744 An08g04280 Aspergillus niger uncharacterized protein XP_059601187.1 1028362 R 5061 CDS An08g04290 4982745 join(1031324..1031389,1031455..1031580,1031632..1032432) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein CAE47925.1 - Aspergillus fumigatus; uncharacterized protein 1032432 4982745 An08g04290 Aspergillus niger uncharacterized protein XP_001392546.1 1031324 D 5061 CDS An08g04300 4982746 join(1035940..1036687,1036751..1037548,1037627..1037817,1037868..1038533) VIII 1 NT_166524.1 Function: ROD1 of S. cerevisiae convers resistance to O-dinitrobenzene, calcium and zinc.; Title: similarity to resistance protein Rod1 -Saccharomyces cerevisiae; plasma membrane; See PMID 8621680; uncharacterized protein 1038533 4982746 An08g04300 Aspergillus niger uncharacterized protein XP_059601188.1 1035940 D 5061 CDS An08g04310 4982747 join(1039349..1039462,1039635..1040186,1040220..1040309,1040364..1040394,1040468..1040496) VIII 1 NT_166524.1 Remark: putative N-acetyltransferase domain; Title: similarity to hypothetical protein SPAC56E4.07 - Schizosaccharomyces pombe; uncharacterized protein 1040496 4982747 An08g04310 Aspergillus niger uncharacterized protein XP_059601189.1 1039349 D 5061 CDS An08g04320 84591651 join(1042545..1042674,1042749..1043407) VIII 1 NT_166524.1 hypothetical protein 1043407 84591651 An08g04320 Aspergillus niger hypothetical protein XP_059601190.1 1042545 D 5061 CDS An08g04330 4982749 1044944..1045756 VIII 1 NT_166524.1 Title: similarity to hypothetical endo alpha-1,4 polygalactosaminidase - Pseudomonas sp.; uncharacterized protein 1045756 4982749 An08g04330 Aspergillus niger uncharacterized protein XP_001392550.1 1044944 D 5061 CDS An08g04335 84591652 complement(join(1046932..1047037,1047214..1047243,1047300..1047514)) VIII 1 NT_166524.1 hypothetical protein 1047514 84591652 An08g04335 Aspergillus niger hypothetical protein XP_059601191.1 1046932 R 5061 CDS An08g04340 84591653 complement(join(1052072..1052350,1052494..1052536,1052566..1052615)) VIII 1 NT_166524.1 hypothetical protein 1052615 84591653 An08g04340 Aspergillus niger hypothetical protein XP_059601192.1 1052072 R 5061 CDS An08g04350 4982752 join(1057363..1057600,1057699..1058270,1058340..1058525) VIII 1 NT_166524.1 Remark: Chs7p is involved in the control of protein export from the endoplasmic reticulum that is specifically engaged in the regulation of chitin synthesis.; Remark: control of protein export from the ER (like chitin synthase III).; Title: similarity to chitin synthase III like Chs7 -Saccharomyces cerevisiae; See PMID 10366589; uncharacterized protein 1058525 4982752 An08g04350 Aspergillus niger uncharacterized protein XP_001392553.1 1057363 D 5061 CDS An08g04360 4982753 complement(join(1059861..1061007,1061071..1061219,1061329..1061370)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein CAE47928.1/AfA28D1.070 - Aspergillus fumigatus; uncharacterized protein 1061370 4982753 An08g04360 Aspergillus niger uncharacterized protein XP_001392554.1 1059861 R 5061 CDS An08g04370 4982754 complement(join(1062597..1062652,1062789..1063578,1063640..1063722,1063782..1063866)) VIII 1 NT_166524.1 Remark: hACTE-III is a peroxisomal acyl-CoA thiolesterase and exhibits enzymatic specificity for a broad range of fatty acyl-CoAs.; Similarity: the human homolog hACTE-III shows similarity to E. coli thioesterase II.; Title: similarity to peroxisomal acyl-CoA thiolesterase hACTE-III - Homo sapiens; peroxisome; See PMID 9299485; uncharacterized protein 1063866 4982754 An08g04370 Aspergillus niger uncharacterized protein XP_059601193.1 1062597 R 5061 CDS An08g04380 4982755 complement(join(1064755..1065064,1065166..1065197,1065271..1065294)) VIII 1 NT_166524.1 Remark: component of the small subunit of mitochondrial ribosome.; Title: similarity to mitochondrial ribosomal protein of the small subunit Mrp17 - Saccharomyces cerevisiae; See PMID 1279374; See PMID 9445368; mitochondrial 37S ribosomal protein bS6m 1065294 4982755 An08g04380 Aspergillus niger mitochondrial 37S ribosomal protein bS6m XP_001392556.1 1064755 R 5061 CDS An08g04390 4982756 join(1065616..1065754,1065839..1065901,1065975..1066291) VIII 1 NT_166524.1 Catalytic activity: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein to (6R)-5,10-methylenetetrahydrofolate + NH(3) + dihydrolipoylprotein.; Pathway: glycine degradation.; Title: strong similarity to glycine decarboxylase subunit H Fun40 - Saccharomyces cerevisiae; See PMID 9020168; uncharacterized protein 1066291 4982756 An08g04390 Aspergillus niger uncharacterized protein XP_001392557.1 1065616 D 5061 CDS An08g04400 4982757 join(1067119..1067427,1067492..1068562) VIII 1 NT_166524.1 Remark: zinc-regulated gene suggested to function in zinc-uptake.; Title: similarity to membrane protein Zrg17 -Saccharomyces cerevisiae; See PMID 10978274; uncharacterized protein 1068562 4982757 An08g04400 Aspergillus niger uncharacterized protein XP_001392558.1 1067119 D 5061 CDS An08g04410 4982758 complement(join(1069262..1069518,1069660..1069693)) VIII 1 NT_166524.1 Catalytic activity: NADH + ubiquinone <=> NAD(+) + ubiquinol.; Remark: identical to Aspergillus niger EST AN05D07.; Title: strong similarity to hypothetical 14 kD subunit of NADH:ubiquinone reductase - Neurospora crassa; uncharacterized protein 1069693 4982758 An08g04410 Aspergillus niger uncharacterized protein XP_001392559.1 1069262 R 5061 CDS An08g04420 4982759 join(1070057..1070281,1070369..1071542,1071607..1072415,1072562..1072585) VIII 1 NT_166524.1 Title: similarity to hypothetical protein CAE47939.1 - Aspergillus fumigatus; uncharacterized protein 1072585 4982759 An08g04420 Aspergillus niger uncharacterized protein XP_059601194.1 1070057 D 5061 CDS An08g04430 4982760 complement(join(1072750..1072770,1072899..1072910,1072954..1072979,1073126..1073347,1073456..1073939)) VIII 1 NT_166524.1 Function: human cap-binding protein 4EHP binds specifically to capped RNA in an ATP- and divalent ion-independent manner.; Remark: control of gene expression at the translational level plays an important role in cell growth and proliferation.; Remark: several pathways transmit signals from extracellular stimuli to translation components. a key participant in this regulation of translation is eIF4E, the mRNA 5' cap-binding protein.; Similarity: the predicted A. niger protein shows strong similarity to human 4E homologous protein (4EHP),human translation initiation factor 4E and other eukaryotic eIF4E-like proteins.; Title: similarity to cap-binding protein 4EHP - Homo sapiens; See PMID 9582349; See PMID 9561852; uncharacterized protein 1073939 4982760 An08g04430 Aspergillus niger uncharacterized protein XP_001392561.3 1072750 R 5061 CDS An08g04440 4982761 join(1074893..1075411,1075465..1075665) VIII 1 NT_166524.1 Title: similarity to hypothetical protein EAA66199.1 - Aspergillus nidulans; uncharacterized protein 1075665 4982761 An08g04440 Aspergillus niger uncharacterized protein XP_001392562.1 1074893 D 5061 CDS An08g04450 4982762 complement(join(1076016..1076073,1076128..1077472,1077534..1077816)) VIII 1 NT_166524.1 Catalytic activity: GDP + H2O = GMP + Orthophosphate.; Title: similarity to hypothetical guanosine-diphosphatase - Schizosaccharomyces pombe; uncharacterized protein 1077816 4982762 An08g04450 Aspergillus niger uncharacterized protein XP_001392563.1 1076016 R 5061 CDS An08g04460 4982763 1078474..1079163 VIII 1 NT_166524.1 Function: IF-3 binds to the 30S ribosomal subunit in prokaryotes and shifts the equlibrium between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.; Remark: subunit: monomer; Title: similarity to translation initiation factor IF-3 - Bacillus stearothermophilus; uncharacterized protein 1079163 4982763 An08g04460 Aspergillus niger uncharacterized protein XP_001392564.1 1078474 D 5061 CDS An08g04470 4982764 join(1079812..1079977,1080036..1080064,1080147..1080409,1080473..1081152,1081214..1081398) VIII 1 NT_166524.1 Title: strong similarity to mitochondrial elongation factor Tu - Arabidopsis thaliana; localisation:mitochondrion; uncharacterized protein 1081398 4982764 An08g04470 Aspergillus niger uncharacterized protein XP_001392565.1 1079812 D 5061 CDS An08g04480 4982765 join(1082317..1082417,1082581..1083018,1083079..1084823,1084881..1085173) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein B3E4.60 - Neurospora crassa; uncharacterized protein 1085173 4982765 An08g04480 Aspergillus niger uncharacterized protein XP_001392566.1 1082317 D 5061 CDS An08g04490 4982766 join(1085800..1086039,1086134..1086251,1086307..1086461,1086511..1086633,1086683..1086855,1086901..1086988,1087041..1087146,1087208..1087367,1087428..1087628,1087696..1087912) VIII 1 NT_166524.1 Gene-ID: EPR; endoprotease Endo-Pro-Aspergillus niger 1087912 EPR 4982766 EPR Aspergillus niger endoprotease Endo-Pro-Aspergillus niger XP_059603985.1 1085800 D 5061 CDS An08g04500 4982767 join(1089166..1089805,1089854..1089912,1089965..1091330,1091375..1093731) VIII 1 NT_166524.1 Title: strong similarity to ATP-binding cassette multidrug transport protein atrA - Aspergillus nidulans; plasma membrane; See PMID 9180695; uncharacterized protein 1093731 4982767 An08g04500 Aspergillus niger uncharacterized protein XP_001392568.1 1089166 D 5061 CDS An08g04510 84591654 join(1094629..1094703,1094771..1094897,1094961..1095001) VIII 1 NT_166524.1 Title: weak similarity to hypothetical protein encoded by An18g06360 - Aspergillus niger; uncharacterized protein 1095001 84591654 An08g04510 Aspergillus niger uncharacterized protein XP_059603986.1 1094629 D 5061 CDS An08g04520 4982769 complement(join(1095179..1096030,1096089..1096202)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein YBR096w -Saccharomyces cerevisiae; uncharacterized protein 1096202 4982769 An08g04520 Aspergillus niger uncharacterized protein XP_001392570.3 1095179 R 5061 CDS An08g04530 4982770 join(1097083..1097209,1097294..1097907,1098068..1098238) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein AAM35689.1 - Xanthomonas axonopodis; uncharacterized protein 1098238 4982770 An08g04530 Aspergillus niger uncharacterized protein XP_001392571.3 1097083 D 5061 CDS An08g04540 4982771 complement(join(1099987..1100072,1100124..1100149,1100438..1100457,1100502..1101175,1101248..1101449)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein CAD27299.1 - Aspergillus fumigatus; uncharacterized protein 1101449 4982771 An08g04540 Aspergillus niger uncharacterized protein XP_059603987.1 1099987 R 5061 CDS An08g04550 4982772 complement(join(<1101925..1102365,1102453..1102771,1102815..1103443,1103632..1103645)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein B1D1.190 - Neurospora crassa [putative frameshift]; putative frameshift; uncharacterized protein 1103645 4982772 An08g04550 Aspergillus niger uncharacterized protein XP_059603988.1 1101925 R 5061 CDS An08g04560 4982773 complement(join(1104352..1105522,1105681..1105724)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein CAD70872.1 - Neurospora crassa; uncharacterized protein 1105724 4982773 An08g04560 Aspergillus niger uncharacterized protein XP_059603989.1 1104352 R 5061 CDS An08g04570 4982774 complement(1106877..1108436) VIII 1 NT_166524.1 Title: strong similarity to hypothetical isobutene-forming enzyme and benzoate 4-hydroxylase P450rm - Rhodotorula minuta; uncharacterized protein 1108436 4982774 An08g04570 Aspergillus niger uncharacterized protein XP_001392575.3 1106877 R 5061 CDS An08g04580 4982775 complement(join(1108766..1109225,1109286..1109411,1109503..1109792)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical short-chain dehydrogenase PA1379 - Pseudomonas aeruginosa; uncharacterized protein 1109792 4982775 An08g04580 Aspergillus niger uncharacterized protein XP_001392576.1 1108766 R 5061 CDS An08g04590 4982776 complement(1110115..1111311) VIII 1 NT_166524.1 Title: similarity to hypothetical scaffold protein CG6385 - Drosophila melanogaster; uncharacterized protein 1111311 4982776 An08g04590 Aspergillus niger uncharacterized protein XP_001392577.1 1110115 R 5061 CDS An08g04600 4982777 complement(join(1111699..1111943,1111998..1112423,1112470..1112588,1112670..1113041,1113087..1113309,1113363..1113418,1113504..1113823)) VIII 1 NT_166524.1 Function: the S. cerevisiae homolog Ptr2p is a peptide transporter that participates in amino acid-inducible peptide transport.; Remark: The DNA and protein sequences are already updates according to the information above. All calculations (like Blast,COGs,mw,pI,. . .) and structural predictions not !!! They will be updated in the next databases release in june 2005.; Remark: imported dipeptides lead to ubiquitin-dependent degradation of Cup9, thereby de-repressing the expression of Ptr2 and increasing the cell's capacity to import peptides in a positive feedback circuit.; Repression: S. cerevisiae Ptr2p expression is repressed by the transcription factor Cup9p.; Title: strong similarity to peptide transporter Ptr2 - Saccharomyces cerevisiae; plasma membrane; uncharacterized protein 1113823 4982777 An08g04600 Aspergillus niger uncharacterized protein XP_059603990.1 1111699 R 5061 CDS An08g04610 84591655 join(1114569..1114731,1114777..1114808) VIII 1 NT_166524.1 hypothetical protein 1114808 84591655 An08g04610 Aspergillus niger hypothetical protein XP_059603991.1 1114569 D 5061 CDS An08g04620 4982779 join(1116292..1117733,1117792..1118143,1118190..1118450,1118499..1118579,1118628..1118657,1118690..1118825,1118869..1118873) VIII 1 NT_166524.1 Title: similarity to inversin mouse invs - Mus musculus; uncharacterized protein 1118873 4982779 An08g04620 Aspergillus niger uncharacterized protein XP_059603992.1 1116292 D 5061 CDS An08g04630 4982780 complement(join(1119060..1120186,1120255..1120360)) VIII 1 NT_166524.1 Remark: similarities correspond to multiple A, T or S-repeats.; hypothetical protein 1120360 4982780 An08g04630 Aspergillus niger hypothetical protein XP_059603993.1 1119060 R 5061 CDS An08g04640 4982781 complement(join(1120824..1121154,1121205..1121505,1121556..1121649,1121695..1121827,1121873..1122756)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical lysosomal pepstatin insensitive protease CLN2 - Canis lupus; uncharacterized protein 1122756 4982781 An08g04640 Aspergillus niger uncharacterized protein XP_001392582.1 1120824 R 5061 CDS An08g04650 84591656 complement(join(1123504..1123981,1124024..1124031)) VIII 1 NT_166524.1 hypothetical protein 1124031 84591656 An08g04650 Aspergillus niger hypothetical protein XP_059603994.1 1123504 R 5061 CDS An08g04660 4982783 join(1127530..1127557,1127612..1127679,1127728..1127882,1127940..1128100,1128165..1128266,1128327..1128387,1128463..1128547,1128612..1129034) VIII 1 NT_166524.1 Catalytic activity: trans,trans-Farnesyl diphosphate + Isopentenyl diphosphate = Pyrophosphate + Geranylgeranyl diphosphate.; Title: strong similarity to geranylgeranyl diphosphate synthase GGPS1 - Homo sapiens; See PMID 10101267; uncharacterized protein 1129034 4982783 An08g04660 Aspergillus niger uncharacterized protein XP_059603995.1 1127530 D 5061 CDS An08g04670 4982784 complement(join(1129256..1129803,1129864..1130414,1130466..1130693,1130826..1130913,1130946..1131033)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical sugar transporter encoded by DRA0271 - Deinococcus radiodurans; uncharacterized protein 1131033 4982784 An08g04670 Aspergillus niger uncharacterized protein XP_059603996.1 1129256 R 5061 CDS An08g04680 84591657 join(1132349..1132472,1132993..1133108,1133234..1133261,1133502..1133734,1134007..1134144) VIII 1 NT_166524.1 hypothetical protein 1134144 84591657 An08g04680 Aspergillus niger hypothetical protein XP_059603997.1 1132349 D 5061 CDS An08g04690 4982786 complement(join(1135575..1135802,1135855..1135923,1135982..1136278,1136338..1136724)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical short chain dehydrogenase SPCC736.13 - Schizosaccharomyces pombe; uncharacterized protein 1136724 4982786 An08g04690 Aspergillus niger uncharacterized protein XP_001392587.1 1135575 R 5061 CDS An08g04700 4982787 join(1137252..1137310,1137364..1137700,1137776..1137924,1138023..1138085,1138166..1138805,1139028..1139364,1139412..1139590,1139661..1139672) VIII 1 NT_166524.1 Title: similarity to hypothetical transcription regulator protein CAA91958.1 - Schizosaccharomyces pombe; uncharacterized protein 1139672 4982787 An08g04700 Aspergillus niger uncharacterized protein XP_059603998.1 1137252 D 5061 CDS An08g04710 4982788 join(1140469..1141546,1141593..1141651) VIII 1 NT_166524.1 hypothetical protein 1141651 4982788 An08g04710 Aspergillus niger hypothetical protein XP_059603999.1 1140469 D 5061 CDS An08g04720 84591658 complement(join(1141790..1141973,1142084..1142124,1142352..1142471)) VIII 1 NT_166524.1 hypothetical protein 1142471 84591658 An08g04720 Aspergillus niger hypothetical protein XP_059604000.1 1141790 R 5061 CDS An08g04730 4982790 complement(join(1142892..1143165,1143215..1143526,1143572..1143695,1143743..1144139,1144210..1144396,1144456..1144607)) VIII 1 NT_166524.1 Catalytic activity: Succinate + Acceptor = Fumarate + Reduced acceptor.; Title: similarity to hypothetical precursor of fumarate reductase flavocytochrome - Shewanella putrefaciens; uncharacterized protein 1144607 4982790 An08g04730 Aspergillus niger uncharacterized protein XP_059604001.1 1142892 R 5061 CDS An08g04740 4982791 join(1144984..1145729,1145776..1147084) VIII 1 NT_166524.1 Induction: priB transcript was abundant in primordia, while preprimordial mycelia and mature fruiting bodies contained lower levels of this transcript.; Remark: PRIB binds to the DNA fragment containing the upstream region of priB.; Remark: the PRIB binding site has a length of 16 bp and the consensus sequence 5' GGGGGGGACAGGANCC 3'.; Similarity: the predicted A. niger protein shows similarity to the PRIB protein of L. edodes and similarity to the GAL4 zinc binuclear cluster homology found in many transcription factors.; Title: similarity to protein PRIB - Lentinus edodes; See PMID 8112580; See PMID 9498550; uncharacterized protein 1147084 4982791 An08g04740 Aspergillus niger uncharacterized protein XP_001392592.3 1144984 D 5061 CDS An08g04750 4982792 1147916..1148863 VIII 1 NT_166524.1 Catalytic activity: L-proline <=> D-proline; Function: the C. sticklandii homolog encodes a proline racemase.; Title: strong similarity to hypothetical protein proline racemase prdF - Clostridium sticklandii; uncharacterized protein 1148863 4982792 An08g04750 Aspergillus niger uncharacterized protein XP_001392593.3 1147916 D 5061 CDS An08g04760 84591659 1149139..1151406 VIII 1 NT_166524.1 Title: similarity to hypothetical tol related protein - Neurospora crassa; uncharacterized protein 1151406 84591659 An08g04760 Aspergillus niger uncharacterized protein XP_059604002.1 1149139 D 5061 CDS An08g04770 4982795 join(1152012..1152205,1152292..1152383,1152426..1152659,1152692..1153103,1153230..1153976,1154043..1154511) VIII 1 NT_166524.1 Function: co-expression of het-e and het-c lead to cell death.; Function: het-e1 of P. anserina is responsible for vegetative incompatibility.; Remark: het-e1 of P. anserina shows also two sequence motifs, a GTP-binding domain and a repeated region that shares similarity with that of the beta-transducin.; Remark: the reactivity of the HET-E protein depends on two functional elements, a GTP-binding domain and several WD40 repeats.; Title: weak similarity to beta transducin-like protein het-e - Podospora anserina; See PMID 10974123; See PMID 7557402; See PMID 9435787; See PMID 10875280; uncharacterized protein 1154511 4982795 An08g04770 Aspergillus niger uncharacterized protein XP_059604003.1 1152012 D 5061 CDS An08g04780 84591660 1154916..>1156252 VIII 1 NT_166524.1 Remark: similarity corresponds only to a central region of H. sapiens ankyrin B protein (Ank repeats). The encoding gene ANK2 undergoes alternative splicing processes, leading to two different splice forms.; Title: similarity to ankyrin Ank2 - Homo sapiens [putative frameshift]; putative frameshift; uncharacterized protein 1156252 84591660 An08g04780 Aspergillus niger uncharacterized protein XP_059604004.1 1154916 D 5061 CDS An08g04790 4982796 complement(join(1156401..1156699,1156929..1157304,1157364..1157431,1157497..1157533,1157583..1157735)) VIII 1 NT_166524.1 Remark: similarity corresponds only to a central region of M. grisea PTH11 protein.; Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; uncharacterized protein 1157735 4982796 An08g04790 Aspergillus niger uncharacterized protein XP_001392597.3 1156401 R 5061 CDS An08g04800 84591661 complement(join(1158295..1158394,1158462..1158673)) VIII 1 NT_166524.1 Title: weak similarity to hypothetical protein encoded by An02g12810 - Aspergillus niger; uncharacterized protein 1158673 84591661 An08g04800 Aspergillus niger uncharacterized protein XP_059604005.1 1158295 R 5061 CDS An08g04810 4982798 1159421..1160533 VIII 1 NT_166524.1 Catalytic activity: 2,5-Dihydro-5-oxofuran-2-acetate = cis,cis-Hexadienedioate; 4-Methylmuconolactone = 3-Methyl-cis,cis-hexadienedioate; Title: strong similarity to muconate cycloisomerase catB - Pseudomonas putida; uncharacterized protein 1160533 4982798 An08g04810 Aspergillus niger uncharacterized protein XP_001392599.1 1159421 D 5061 CDS An08g04820 4982799 complement(join(1161142..1163664,1163718..1163880,1163927..1164165,1164223..1164522)) VIII 1 NT_166524.1 Remark: sequence similarity only corresponds to C-terminal region of M. xanthus saframycin Mx1 synthetase safA.; Title: similarity to saframycin Mx1 synthase safA -Myxococcus xanthus; uncharacterized protein 1164522 4982799 An08g04820 Aspergillus niger uncharacterized protein XP_059604006.1 1161142 R 5061 CDS An08g04830 4982800 complement(join(1165375..1165780,1165861..1166335,1166375..1166579)) VIII 1 NT_166524.1 Remark: no N-terminal homology to M. grisea PTH11.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529; uncharacterized protein 1166579 4982800 An08g04830 Aspergillus niger uncharacterized protein XP_059604007.1 1165375 R 5061 CDS An08g04840 4982801 join(1168125..1168737,1168827..1168876) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein encoded by An08g04850 - Aspergillus niger; uncharacterized protein 1168876 4982801 An08g04840 Aspergillus niger uncharacterized protein XP_001392602.3 1168125 D 5061 CDS An08g04850 4982802 complement(join(1169413..1169441,1169559..1169590,1169630..1170234)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein encoded by An08g04840 - Aspergillus niger; uncharacterized protein 1170234 4982802 An08g04850 Aspergillus niger uncharacterized protein XP_001392603.3 1169413 R 5061 CDS An08g04860 4982803 complement(join(1170790..1172204,1172268..1172332,1172388..1172504,1172614..1172737,1172789..1173383,1173432..1174162,1174222..1174455,1174518..1174797,1174854..1175819)) VIII 1 NT_166524.1 Function: YCF1 of S. cerevisiae is an ABC transporter that confers resistance to cadmium and transports bilirubin into vacuoles.; Remark: a putative sequencing error results in a premature STOP codon.; Title: strong similarity to cadmium resistance protein Ycf1 - Saccharomyces cerevisiae [putative sequencing error]; putative sequencing error; uncharacterized protein 1175819 4982803 An08g04860 Aspergillus niger uncharacterized protein XP_059604008.1 1170790 R 5061 CDS An08g04870 4982804 complement(1177409..1178869) VIII 1 NT_166524.1 Function: het-e of P. anserina is a G protein, and GTP binding is essential in triggering the incompatibility reaction; the GTP-binding domain seems not to be conserved in the predicted protein.; Function: in P. anserina, co-expression of antagonistic alleles of the unlinked loci het-e and het-c triggers a cell death reaction that prevents the formation of viable heterokaryons between strains that contain incompatible combinations of het-c and het-e alleles.; Function: the het-e1 gene of P. anserina is involved in vegetative incompatibility.; Similarity: the similarity to het-e1 of P. anserina is mainly due to the WD repeats, characteristic of the P. anserina protein.; Title: similarity to beta transducin-like protein het-e1 - Podospora anserina; See PMID 7557402; See PMID 9435787; uncharacterized protein 1178869 4982804 An08g04870 Aspergillus niger uncharacterized protein XP_001392605.1 1177409 R 5061 CDS An08g04880 4982805 complement(join(1179868..1180618,1180681..1180721)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein CAD27304.1 - Aspergillus fumigatus; uncharacterized protein 1180721 4982805 An08g04880 Aspergillus niger uncharacterized protein XP_001392606.1 1179868 R 5061 CDS An08g04890 4982806 complement(join(1181211..1181460,1181517..1181995,1182051..1182133,1182194..1182767)) VIII 1 NT_166524.1 Function: nothing can be assessed about the possible function from these data.; Similarity: the ORF shows a very weak similarity to hamster plectin, a cytoskeletal protein, which is ten fold longer than the predicted protein.; Similarity: the ORF shows also similarity to a patented human protein named FLEXHT-12, which means 'Full length molecules expressed in human tissues', claimed to have therapeutical effects against immunological and developmental disorders as well as cancer.; Similarity: the ORF shows also strong similarity to the patented A. oryzae EST SEQ ID NO:4766 (patent number WO200056762-A2).; Title: strong similarity to hypothetical protein SPBC19G7.16 - Schizosaccharomyces pombe; uncharacterized protein 1182767 4982806 An08g04890 Aspergillus niger uncharacterized protein XP_001392607.1 1181211 R 5061 CDS An08g04900 4982807 complement(join(1183885..1183995,1184049..1184704,1184758..1185415)) VIII 1 NT_166524.1 Complex: NUP57 of S. cerevisiae forms complex with Nsp1p, Nup49p, and Nic96p at nuclear pore; this complex participates in nucleocytoplasmic transport; in vitro,Nsp1p, Nup49p and Nup57p form a 1:1:1 stoichiometric complex to which Nic96p can also bind.; Function: NUP57 of S. cerevisiae is required for protein transport in the nucleus.; Title: similarity to nuclear pore protein Nup57 -Saccharomyces cerevisiae; See PMID 7828598; See PMID 9017593; See PMID 9476893; See PMID 9725905; See PMID 9813081; uncharacterized protein 1185415 4982807 An08g04900 Aspergillus niger uncharacterized protein XP_001392608.1 1183885 R 5061 CDS An08g04910 4982808 join(1186047..1186066,1186221..1186448,1186542..1186674,1186756..1186854) VIII 1 NT_166524.1 Catalytic activity: NADH + ubiquinone = NAD+ + ubiquinol.; Complex: the 22 kDa chain of N. crassa is a component of the mitochondrial ubiquinone reductase, also known as complex I.; Function: complex I is a flavoprotein containing iron-sulfur centres and is an essential component of the respiratory chain.; Title: strong similarity to 22 kD subunit NADH:ubiquinone reductase - Neurospora crassa; localisation:mitochondrion; See PMID 2142943; See PMID 2523803; See PMID 9593837; uncharacterized protein 1186854 4982808 An08g04910 Aspergillus niger uncharacterized protein XP_001392609.1 1186047 D 5061 CDS An08g04920 4982809 complement(join(1187135..1187158,1187545..1188445,1188503..1188575,1188681..1188794,1188891..1188906)) VIII 1 NT_166524.1 Remark: endozepine (EP) is also called diazepam binding inhibitor (DBI) or acyl-coenzyme A (CoA)-binding protein (ACBP).; Remark: for a review about endozepine functions in higher organisms see OMIM record n. 125950.; Title: strong similarity to hypothetical endozepine CAD27308.1 - Aspergillus fumigatus; uncharacterized protein 1188906 4982809 An08g04920 Aspergillus niger uncharacterized protein XP_001392610.3 1187135 R 5061 CDS An08g04930 4982810 complement(join(1189569..1190472,1190534..1191094,1191167..1191270)) VIII 1 NT_166524.1 Induction: transcription of the gabA gene of A. nidulans is activated by the transcription factor IntA.; Remark: in A. niger GABA is used as a nitrogen source.; Remark: in agreement with the wealth of genetic data available, transcript level analyses demonstrate that gabA (A. nidulans) is subject to carbon catabolite and nitrogen metabolite repression, omega-amino acid induction and regulation in response to ambient pH (being acid-expressed).; Repression: transcription of the gabA gene of A. nidulans is repressed by the zinc finger transcription factor PacC.; Similarity: the predicted A. niger protein shows also similarity to several putative fungal amino acid permeases.; Title: strong similarity to GABA permease gabA -Aspergillus nidulans; See PMID 10320578; uncharacterized protein 1191270 4982810 An08g04930 Aspergillus niger uncharacterized protein XP_001392611.1 1189569 R 5061 CDS An08g04940 84591662 complement(join(1191544..1191761,1192063..1192178,1192256..1192317)) VIII 1 NT_166524.1 hypothetical protein 1192317 84591662 An08g04940 Aspergillus niger hypothetical protein XP_059604009.1 1191544 R 5061 CDS An08g04950 84591663 join(1192349..1192409,1192610..1192859,1193110..1193308) VIII 1 NT_166524.1 hypothetical protein 1193308 84591663 An08g04950 Aspergillus niger hypothetical protein XP_059604010.1 1192349 D 5061 CDS An08g04960 84591664 complement(join(1193666..1194454,1194488..1195630)) VIII 1 NT_166524.1 Similarity: the similarity to the patented EST is more significant than the weak BLASTP similarities, mainly produced by the high content of low-complexity regions within the predicted protein.; Title: strong similarity to hypothetical transcription factor CAD27310.1 - Aspergillus fumigatus; uncharacterized protein 1195630 84591664 An08g04960 Aspergillus niger uncharacterized protein XP_059604011.1 1193666 R 5061 CDS An08g04970 4982813 complement(join(1195772..1196832,1196901..1197356,1197636..1197823,1197890..1197975,1198051..1198305)) VIII 1 NT_166524.1 Similarity: in the predicted protein two domains,described in the jumonji family of transcription factors,are also present, further supporting the involvement in transcription.; Similarity: the predicted protein is very similar to the N-terminal part of S. cerevisiae RPH1, also known as YER169W, a transcription factor implicated in the regulation of the DNA-repair protein PHR1; RPH1 binds DNA via zinc fingers located in its C-terminal, that are not conserved in the predicted protein.; Title: similarity to regulator protein Rph1 -Saccharomyces cerevisiae; See PMID 7758946; See PMID 10523651; See PMID 10838566; uncharacterized protein 1198305 4982813 An08g04970 Aspergillus niger uncharacterized protein XP_059604012.1 1195772 R 5061 CDS An08g04980 84591665 join(1198315..1198435,1198620..1198752,1198843..1199152) VIII 1 NT_166524.1 hypothetical protein 1199152 84591665 An08g04980 Aspergillus niger hypothetical protein XP_059604013.1 1198315 D 5061 CDS An08g04990 4982816 complement(join(1201896..1202023,1202089..1204011,1204070..1204099,1204175..1204496)) VIII 1 NT_166524.1 Catalytic activity: Acetyl-CoA + Carnitine = CoA + O-Acetylcarnitine.; Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to carnitine acetyl transferase facC - Aspergillus nidulans; cytoplasm; uncharacterized protein 1204496 4982816 An08g04990 Aspergillus niger uncharacterized protein XP_001392617.3 1201896 R 5061 CDS An08g05000 84591666 join(1204595..1204606,1204683..1204913,1204989..1205162,1205335..1205443,1205545..1205841,1206250..1206388,1206502..1206604) VIII 1 NT_166524.1 hypothetical protein 1206604 84591666 An08g05000 Aspergillus niger hypothetical protein XP_059604014.1 1204595 D 5061 CDS An08g05010 4982818 complement(join(1206746..1206816,1206880..1207169,1207228..1207912,1208165..1208416,1208464..1208560,1208741..1208848,1208889..1209035)) VIII 1 NT_166524.1 Title: similarity to hypothetical pathogenesis-related protein CAD27313.1 - Aspergillus fumigatus; uncharacterized protein 1209035 4982818 An08g05010 Aspergillus niger uncharacterized protein XP_059604015.1 1206746 R 5061 CDS An08g05020 84591667 complement(join(1209232..1209273,1209359..1209552,1209776..1209868,1209951..1210053,1210151..1210212,1210422..1210523,1210565..1210639,1210729..1210815,1210891..1210986,1211053..1211098)) VIII 1 NT_166524.1 hypothetical protein 1211098 84591667 An08g05020 Aspergillus niger hypothetical protein XP_059604016.1 1209232 R 5061 CDS An08g05030 4982820 complement(join(1212233..1212873,1212929..1213873,1213904..1214434,1214491..1214609,1214660..1214721)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical conserved protein aq_2146 - Aquifex aeolicus; uncharacterized protein 1214721 4982820 An08g05030 Aspergillus niger uncharacterized protein XP_059604017.1 1212233 R 5061 CDS An08g05050 4982821 complement(join(1215368..1215622,1215707..1216372,1216458..1216623,1216694..1216734)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical WD-repeat protein CAA21197.1 - Schizosaccharomyces pombe; uncharacterized protein 1216734 4982821 An08g05050 Aspergillus niger uncharacterized protein XP_001392622.1 1215368 R 5061 CDS An08g05060 4982822 join(1217205..1217221,1217256..1217327,1217435..1217678,1218050..1219324) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein encoded by AfA14E5.29 - Aspergillus fumigatus; cytoplasm; uncharacterized protein 1219324 4982822 An08g05060 Aspergillus niger uncharacterized protein XP_059604018.1 1217205 D 5061 CDS An08g05070 4982823 join(1220733..1220870,1220938..1221020,1221084..1221228,1221308..1221343,1221402..1221999,1222080..1222120) VIII 1 NT_166524.1 Title: similarity to hypothetical protein SCIF3.09c - Streptomyces coelicolor; uncharacterized protein 1222120 4982823 An08g05070 Aspergillus niger uncharacterized protein XP_001392624.1 1220733 D 5061 CDS An08g05080 4982824 complement(1222644..1224305) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein CAE47974.1 - Aspergillus fumigatus; uncharacterized protein 1224305 4982824 An08g05080 Aspergillus niger uncharacterized protein XP_001392625.3 1222644 R 5061 CDS An08g05090 84591668 1224363..1225124 VIII 1 NT_166524.1 hypothetical protein 1225124 84591668 An08g05090 Aspergillus niger hypothetical protein XP_059604019.1 1224363 D 5061 CDS An08g05100 4982826 complement(join(1225956..1227475,1227547..1227694)) VIII 1 NT_166524.1 Remark: veA influences the production of the extracellular signal and regulates the initiation of conidiation due to a genetic interaction with fluG in Aspergillus nidulans.; Title: strong similarity to dark repressor of conidiation velvet veA - Aspergillus nidulans; See PMID 9691036; uncharacterized protein 1227694 4982826 An08g05100 Aspergillus niger uncharacterized protein XP_001392627.1 1225956 R 5061 CDS An08g05110 84591669 join(1227932..1228017,1228112..1228336,1228390..1228479,1228577..1228673,1228900..1228997,1229234..1229441,1229777..1229800,1229892..1229953,1230224..1230447,1230507..1230575,1230654..1230709,1230762..1230854,1230924..1230959,1231009..1231044,1231176..1231217) VIII 1 NT_166524.1 hypothetical protein 1231217 84591669 An08g05110 Aspergillus niger hypothetical protein XP_059604020.1 1227932 D 5061 CDS An08g05120 84591670 join(1231235..1231384,1231417..1231506) VIII 1 NT_166524.1 hypothetical protein 1231506 84591670 An08g05120 Aspergillus niger hypothetical protein XP_059604021.1 1231235 D 5061 CDS An08g05130 84591671 complement(join(1231631..1231923,1232141..1232203,1232400..1232494,1232629..1232729)) VIII 1 NT_166524.1 hypothetical protein 1232729 84591671 An08g05130 Aspergillus niger hypothetical protein XP_059604022.1 1231631 R 5061 CDS An08g05140 84591672 join(1233094..1233244,1233322..1233613,1233733..1233842,1234452..1234532,1235401..1235506,1235589..1235685,1235780..1235979,1236033..1236074,1236171..1236256,1236346..1236428,1236517..1236704,1237140..1237189,1237363..1237396,1237491..1237590,1237708..1237941) VIII 1 NT_166524.1 Title: questionable ORF; uncharacterized protein 1237941 84591672 An08g05140 Aspergillus niger uncharacterized protein XP_059604023.1 1233094 D 5061 CDS An08g05150 4982831 join(1238509..1238703,1238743..1238772,1238812..1238903,1238979..1239626,1239732..1240317) VIII 1 NT_166524.1 Remark: alternate names = YDR004W, YD8119. 10; Remark: rad57 is involved in DNA double-strand gap repair in S. cerevisiae.; Title: strong similarity to protein Rad57 -Saccharomyces cerevisiae; nucleus; See PMID 7624345; See PMID 9933354; uncharacterized protein 1240317 4982831 An08g05150 Aspergillus niger uncharacterized protein XP_059604024.1 1238509 D 5061 CDS An08g05160 4982832 complement(join(1241263..1241669,1241732..1242725)) VIII 1 NT_166524.1 Catalytic activity: oleate delta-12 desaturase catalyzes the conversion of linoleate + AH2 + O2 = crepenynate + A + H2O.; EC:1.14.99.33; Functin: deletion of odeA in Anidulans resulted in a strain depleted of polyunsaturated fatty acids (18:2 and 18:3) but increased in oleic acid (18:1) and total percent fatty acid content; linoleic acid-derived psi factors were absent in this strain but oleic acid-derived psi factors were increased relative to wild type.; Function: The DeltaodeA A. nidulans strain was reduced in conidial production and mycelial growth; these effects were most noticeable when cultures were grown at 26 degrees C in the dark; under these environmental conditions, the Delta odeA strain was delayed in ascospore production but produced more ascospores than wild type over time.; Function: odeA of A. nidulans encodes a Delta-12 desaturase that converts oleic acid to linoleic acid.; Title: strong similarity to oleate delta-12 desaturase odeA - Aspergillus nidulans; See PMID 11352908; uncharacterized protein 1242725 4982832 An08g05160 Aspergillus niger uncharacterized protein XP_001392633.1 1241263 R 5061 CDS An08g05170 84591673 join(1243131..1243250,1243300..1243393,1243575..1243702,1243747..1243875) VIII 1 NT_166524.1 hypothetical protein 1243875 84591673 An08g05170 Aspergillus niger hypothetical protein XP_059604025.1 1243131 D 5061 CDS An08g05180 84591674 complement(join(1246177..1246726,1246756..1246763)) VIII 1 NT_166524.1 Remark: the protein is C-terminally about 1200 aminoacids shorter than the matching protein #901 from patent WO200286090-A2.; Title: strong similarity to essential protein #901 from patent WO200286090-A2 - Aspergillus fumigatus; uncharacterized protein 1246763 84591674 An08g05180 Aspergillus niger uncharacterized protein XP_059604026.1 1246177 R 5061 CDS An08g05190 4982835 complement(join(1246914..1247965,1248068..1250431,1250468..1250774)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein GT334 -Homo sapiens; uncharacterized protein 1250774 4982835 An08g05190 Aspergillus niger uncharacterized protein XP_059604027.1 1246914 R 5061 CDS An08g05200 4982836 complement(join(1251433..1251564,1251627..1253638,1253867..1254120,1254183..1255160,1255226..1255284)) VIII 1 NT_166524.1 Remark: SPT23 is required for transcription of the delta9 fatty acid desaturase gene OLE1 in S. cerevisiae.; Remark: SPT23 may exert its suppression effect in S. cerevisiae through protein-protein interactions since does not present any of the motifs generally found in transcriptional regulators or dna binding proteins.; Remark: alternate name in S. cerevisiae = YKL020C.; Title: strong similarity to transcription suppressor protein Spt23 - Saccharomyces cerevisiae; nucleus; See PMID 8203154; See PMID 9927444; uncharacterized protein 1255284 4982836 An08g05200 Aspergillus niger uncharacterized protein XP_059604028.1 1251433 R 5061 CDS An08g05210 84591675 join(1256017..1256076,1256159..1256327,1256431..1256571,1256688..1256808,1256968..1257113,1257188..1257322,1257795..1258013,1258107..1258225) VIII 1 NT_166524.1 hypothetical protein 1258225 84591675 An08g05210 Aspergillus niger hypothetical protein XP_059604029.1 1256017 D 5061 CDS An08g05220 84591676 complement(join(1258910..1258989,1259082..1259199,1259280..1259345,1259423..1259579,1259912..1260166,1260294..1260411,1260487..1260532)) VIII 1 NT_166524.1 hypothetical protein 1260532 84591676 An08g05220 Aspergillus niger hypothetical protein XP_059604030.1 1258910 R 5061 CDS An08g05230 4982839 1260764..1261972 VIII 1 NT_166524.1 Title: strong similarity to hypothetical endoglucanase IV - Trichoderma reesei; uncharacterized protein 1261972 4982839 An08g05230 Aspergillus niger uncharacterized protein XP_001392640.1 1260764 D 5061 CDS An08g05240 84591677 join(1262492..1262827,1262866..1263013,1263090..1263178) VIII 1 NT_166524.1 hypothetical protein 1263178 84591677 An08g05240 Aspergillus niger hypothetical protein XP_059604031.1 1262492 D 5061 CDS An08g05250 4982841 join(1263223..1264339,1264498..1265588) VIII 1 NT_166524.1 Similarity: there is another blastp hit to mouse ligatin, a trafficking receptor for phosphoglycoproteins.; Title: similarity to hypothetical protein YDR117c -Saccharomyces cerevisiae; uncharacterized protein 1265588 4982841 An08g05250 Aspergillus niger uncharacterized protein XP_059604032.1 1263223 D 5061 CDS An08g05260 4982842 complement(join(1266209..1266314,1266400..1267481)) VIII 1 NT_166524.1 Remark: S. cerevisiae LAH1 binds to the precursors of polymerase III RNAs, preferentially to precursors ending in U residues.; Remark: alternate names in S. cerevisiae = LHP1,YLA1, YDL051W.; Title: similarity to RNA-binding protein Lah1 -Saccharomyces cerevisiae; See PMID 7799435; See PMID 9412461; uncharacterized protein 1267481 4982842 An08g05260 Aspergillus niger uncharacterized protein XP_001392643.1 1266209 R 5061 CDS An08g05270 84591678 join(1267678..1267740,1267906..1267992) VIII 1 NT_166524.1 Title: questionable ORF; uncharacterized protein 1267992 84591678 An08g05270 Aspergillus niger uncharacterized protein XP_059604033.1 1267678 D 5061 CDS An08g05278 4982844 join(1268401..1268754,1268807..1268965) VIII 1 NT_166524.1 hypothetical protein 1268965 4982844 An08g05278 Aspergillus niger hypothetical protein XP_001392645.1 1268401 D 5061 CDS An08g05290 4982845 join(1269741..1269791,1269938..1270020,1270067..1272182) VIII 1 NT_166524.1 Catalytic activity: UDP-N-acetyl-D-glucosamine + [(1, 4)-(N-acetyl-beta-D-glucosaminyl)](N) <=> UDP + [(1,4)-(N-acetyl-beta-D-glucosaminyl)](N+1).; Title: strong similarity to class VI chitin synthase chsD - Aspergillus fumigatus; plasma membrane; See PMID 8807804; uncharacterized protein 1272182 4982845 An08g05290 Aspergillus niger uncharacterized protein XP_059604034.1 1269741 D 5061 CDS An08g05300 4982846 join(1273326..1273400,1273514..1273545,1273660..1275091,1275153..1275461,1275522..1275812) VIII 1 NT_166524.1 Remark: alternate names in Schizosaccharomyces pombe = STI1, STIL or SPCC645. 14C; Title: strong similarity to heat shock protein Hsp70 ss1p - Schizosaccharomyces pombe; See PMID 9524252; uncharacterized protein 1275812 4982846 An08g05300 Aspergillus niger uncharacterized protein XP_001392647.1 1273326 D 5061 CDS An08g05310 4982847 complement(join(1276460..1277162,1277220..1277652,1277718..1277832)) VIII 1 NT_166524.1 Title: weak similarity to hypothetical protein encoded by An19g00360 - Aspergillus niger; uncharacterized protein 1277832 4982847 An08g05310 Aspergillus niger uncharacterized protein XP_001392648.1 1276460 R 5061 CDS An08g05320 4982848 join(1278435..1278879,1278949..1279481) VIII 1 NT_166524.1 Catalytic activity: Estradiol-17-beta + NAD(P)(+) <=> estrone + NAD(P)H; Title: strong similarity to estradiol 17beta-dehydrogenase type 2 17beta-HSD - Homo sapiens; See PMID 8099587; uncharacterized protein 1279481 4982848 An08g05320 Aspergillus niger uncharacterized protein XP_059604035.1 1278435 D 5061 CDS An08g05330 4982849 complement(join(1279769..1279917,1279975..1280241,1280298..1281411)) VIII 1 NT_166524.1 Catalytic activity: RH + Reduced flavoprotein + O2 = ROH + Oxidized flavoprotein.; Title: strong similarity to n-alkane-inducible cytochrome P450 protein ALK1 - Yarrowia lipolytica; See PMID 9848230; uncharacterized protein 1281411 4982849 An08g05330 Aspergillus niger uncharacterized protein XP_001392650.1 1279769 R 5061 CDS An08g05340 84591679 join(1281842..1283430,1283473..1283845) VIII 1 NT_166524.1 Remark: catalyzes the cyclization of squalene into hopene, a function analogous to the action of oxidosqualene cyclases (OSCs) in eukaryotic steroid and triterpenoid biosynthesis.; Title: strong similarity to squalene hopene cyclase SHC - Alicyclobacillus acidocaldarius; See PMID 9295270; See PMID 10375539; uncharacterized protein 1283845 84591679 An08g05340 Aspergillus niger uncharacterized protein XP_059604036.1 1281842 D 5061 CDS An08g05350 4982850 join(1285249..1285476,1285554..1286834) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein encoded by An18g00300 - Aspergillus niger; uncharacterized protein 1286834 4982850 An08g05350 Aspergillus niger uncharacterized protein XP_001392651.3 1285249 D 5061 CDS An08g05360 4982852 join(1287035..1287356,1287411..1287985,1288046..1288600,1288658..1290618,1290683..1290798,1290853..>1291105) VIII 1 NT_166524.1 Remark: a putative sequencing error within the fourth exon results in a frameshift.; Remark: expression of AFUMDR1 from Aspergillus flavus in S. cerevisiae conferred increased resistance to the antifungal agent cilofungin (LY121019), an echinocandin B analog.; Title: strong similarity to multidrug resistance protein mdr1 - Aspergillus flavus [putative frameshift]; plasma membrane; putative frameshift; See PMID 9373135; uncharacterized protein 1291105 4982852 An08g05360 Aspergillus niger uncharacterized protein XP_059604037.1 1287035 D 5061 CDS An08g05370 84591680 join(1291813..1292015,1292107..1292139,1292222..1292314,1292459..1292593,1292798..1292870) VIII 1 NT_166524.1 hypothetical protein 1292870 84591680 An08g05370 Aspergillus niger hypothetical protein XP_059604038.1 1291813 D 5061 CDS An08g05380 4982854 join(1292885..1293018,1293391..1293482,1293731..1294044,1294109..1294536,1294588..1294653,1294757..1294817) VIII 1 NT_166524.1 Function: MNN4 transfers mannosylphosphate from GDP-mannose to N-linked oligosaccharide.; Remark: only partial similarity to MNN4 of the yeast S. cerrevisiae.; Title: similarity to mannosylphosphate transferase Mnn4 - Saccharomyces cerevisiae; See PMID 355255; See PMID 9023541; uncharacterized protein 1294817 4982854 An08g05380 Aspergillus niger uncharacterized protein XP_059604039.1 1292885 D 5061 CDS An08g05390 4982855 join(1295229..1295599,1295624..1296275) VIII 1 NT_166524.1 Title: strong similarity to hypothetical zinc-metalloprotease SPCC1442.07c - Schizosaccharomyces pombe; uncharacterized protein 1296275 4982855 An08g05390 Aspergillus niger uncharacterized protein XP_059604040.1 1295229 D 5061 CDS An08g05400 4982856 complement(join(1296420..1296847,1296911..1297487,1297550..1297730,1297784..1297854)) VIII 1 NT_166524.1 Catalytic activity: Acyl-CoA + acetyl-CoA <=> CoA + 3-oxoacyl-CoA.; Remark: alternate name for acetyl-CoA C-acyltransferase = 3-oxoacyl-CoA thiolase.; Title: strong similarity to peroxisomal acetyl-CoA C-acyltransferase POT1 - Yarrowia lipolytica; peroxisome; uncharacterized protein 1297854 4982856 An08g05400 Aspergillus niger uncharacterized protein XP_001392657.1 1296420 R 5061 CDS An08g05410 4982857 complement(join(1298443..1299389,1299630..1299651)) VIII 1 NT_166524.1 Title: weak similarity to LIS1-interacting protein Nude1 - Rattus norvegicus; See PMID 11163259; See PMID 10940388; uncharacterized protein 1299651 4982857 An08g05410 Aspergillus niger uncharacterized protein XP_059604041.1 1298443 R 5061 CDS An08g05420 4982858 join(1299985..1300057,1300115..1300221,1300281..1301184,1301277..1301413) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein SPBC27.02c - Schizosaccharomyces pombe; uncharacterized protein 1301413 4982858 An08g05420 Aspergillus niger uncharacterized protein XP_001392659.3 1299985 D 5061 CDS An08g05430 84591681 join(1301746..1301818,1302007..1302125) VIII 1 NT_166524.1 Title: weak similarity to cytoplasmic ribosomal protein of the large subunit L27 rpmA - Rickettsia prowazekii; uncharacterized protein 1302125 84591681 An08g05430 Aspergillus niger uncharacterized protein XP_059604042.1 1301746 D 5061 CDS An08g05440 4982860 complement(join(1302400..1302899,1302952..1303032,1303110..1303271,1303314..1305849,1305930..1306004)) VIII 1 NT_166524.1 Remark: DBM1 in S. cerevisiae is a GTPase-activating protein (GAP) for cdc42 and/or rho1.; Remark: DBM1 in S. cerevisiae is involved in the control of pheromone-response pathway, in polarized cell growth and proper bud site selection.; Similarity: occuring blastp matches against N-chimerins are likely to be restricted to the chimerin-GTPase-activating domain.; Title: similarity to Rho-type GTPase-activating protein Dbm1 - Saccharomyces cerevisiae; See PMID 8657111; uncharacterized protein 1306004 4982860 An08g05440 Aspergillus niger uncharacterized protein XP_059604043.1 1302400 R 5061 CDS An08g05450 4982861 complement(join(1307615..1308399,1308475..1310093,1310181..1311634,1311717..1311841,1311912..1312044)) VIII 1 NT_166524.1 Function: atrDp is involved in protection against cytotoxic compounds.; Title: strong similarity to multidrug resistance protein atrD - Aspergillus nidulans; plasma membrane; See PMID 10954082; uncharacterized protein 1312044 4982861 An08g05450 Aspergillus niger uncharacterized protein XP_059604044.1 1307615 R 5061 CDS An08g05460 84591682 complement(join(1312200..1312549,1312618..1312732,1313107..1313210,1313311..1313353)) VIII 1 NT_166524.1 Remark: adenosine and AMP deaminase signature at aa position 111-118.; hypothetical protein 1313353 84591682 An08g05460 Aspergillus niger hypothetical protein XP_059604045.1 1312200 R 5061 CDS An08g05470 4982863 complement(join(1315379..1315540,1315727..1315871,1315990..1316556,1316645..1316775,1317043..1318573,1318636..1319937,1319988..1320106,1320160..1320783)) VIII 1 NT_166524.1 Function: STU1 is essential for growth in S. cerevisiae, and disruption of STU1 causes defects in spindle assembly in yeast.; Title: similarity to mitotic spindle protein Stu1 -Saccharomyces cerevisiae; cytoskeleton; See PMID 7806575; See PMID 10816255; uncharacterized protein 1320783 4982863 An08g05470 Aspergillus niger uncharacterized protein XP_001392664.3 1315379 R 5061 CDS An08g05480 84591683 join(1321033..1321098,1321177..1321306,1322337..1322515) VIII 1 NT_166524.1 hypothetical protein 1322515 84591683 An08g05480 Aspergillus niger hypothetical protein XP_059604046.1 1321033 D 5061 CDS An08g05490 4982865 1322750..1323634 VIII 1 NT_166524.1 Title: similarity to hypothetical protein At2g15220 - Arabidopsis thaliana; uncharacterized protein 1323634 4982865 An08g05490 Aspergillus niger uncharacterized protein XP_001392666.1 1322750 D 5061 CDS An08g05500 4982866 complement(join(1324123..1324717,1324823..1325343)) VIII 1 NT_166524.1 Title: strong similarity to mitochondrial ribosomal protein of the large subunit Yml3 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 3060376; mitochondrial 54S ribosomal protein mL44 1325343 4982866 An08g05500 Aspergillus niger mitochondrial 54S ribosomal protein mL44 XP_059604047.1 1324123 R 5061 CDS An08g05510 4982867 join(1325558..1325724,1325790..1325972,1326047..1326104) VIII 1 NT_166524.1 Title: similarity to EST r4b11a1.f1 - Aspergillus nidulans; uncharacterized protein 1326104 4982867 An08g05510 Aspergillus niger uncharacterized protein XP_001392668.3 1325558 D 5061 CDS An08g05520 4982868 complement(join(1326231..1326478,1326548..1327093,1327154..1327469)) VIII 1 NT_166524.1 Function: PET18 (= MAK31 +MAK32) is necessary for the structural stability of L-A dsRNA-containing particles,but not of those containing L-A (+) strand RNA in yeast.; Remark: there are five families of double-stranded RNA (dsRNA) in strains of S. cerevisiae, called L-A, L-BC,M, T, and W.; Title: strong similarity to Mak32 - Saccharomyces cerevisiae; See PMID 3551911; See PMID 3916862; uncharacterized protein 1327469 4982868 An08g05520 Aspergillus niger uncharacterized protein XP_059604048.1 1326231 R 5061 CDS An08g05530 4982869 join(1328012..1328058,1328186..1328435,1328489..1328790,1328846..1329839) VIII 1 NT_166524.1 Alternative name: SRV2.; Function: protein is required for RAS-activated adenylate cyclase activity (synthesizes cAMP from ATP).; Remark: adenylyl cyclase from S. cerevisiae contains at least two subunits, a 200 kd catalytic subunit and a 70 kd subunit (cyclase-associated protein).; Title: strong similarity to adenylate cyclase-associated protein Cap1 - Saccharomyces cerevisiae; See PMID 2158860; See PMID 2184942; uncharacterized protein 1329839 4982869 An08g05530 Aspergillus niger uncharacterized protein XP_001392670.1 1328012 D 5061 CDS An08g05540 4982870 complement(join(1330992..1333094,1333217..1333507)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein encoded by FLJ10980 - Homo sapiens; uncharacterized protein 1333507 4982870 An08g05540 Aspergillus niger uncharacterized protein XP_059604049.1 1330992 R 5061 CDS An08g05550 84591684 join(1333534..1333773,1333872..1334072) VIII 1 NT_166524.1 hypothetical protein 1334072 84591684 An08g05550 Aspergillus niger hypothetical protein XP_059604050.1 1333534 D 5061 CDS An08g05560 4982872 join(1334421..1334559,1334618..1335126) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein CAF31995.1 - Aspergillus fumigatus; uncharacterized protein 1335126 4982872 An08g05560 Aspergillus niger uncharacterized protein XP_059604051.1 1334421 D 5061 CDS An08g05570 4982873 complement(join(1335306..1336034,1336110..1338500)) VIII 1 NT_166524.1 Title: similarity to secretory protein Sec5 -Saccharomyces cerevisiae; See PMID 3077331; See PMID 9153755; uncharacterized protein 1338500 4982873 An08g05570 Aspergillus niger uncharacterized protein XP_001392674.1 1335306 R 5061 CDS An08g05580 4982874 join(1338556..1338627,1338684..1338860,1339216..1339281,1339440..1339526,1339595..1339717,1339780..1340499,1340567..1340638) VIII 1 NT_166524.1 Catalytic activity: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.; Remark: isocitrate dehydrogenase from S. cerevisiae is composed of two nonidentical subunits, IDH1 and IDH2.; Title: strong similarity to precursor of isocitrate dehydrogenase (NAD+) chain Idh2 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 1939242; uncharacterized protein 1340638 4982874 An08g05580 Aspergillus niger uncharacterized protein XP_059604052.1 1338556 D 5061 CDS An08g05590 4982875 complement(join(1341020..1341366,1341449..1341632,1341722..1341867,1341963..1342131)) VIII 1 NT_166524.1 Similarity: the ORF is shorter than the yeast protein (281 compared to 425 amino acids).; Title: weak similarity to hypothetical protein YNL136w - Saccharomyces cerevisiae; uncharacterized protein 1342131 4982875 An08g05590 Aspergillus niger uncharacterized protein XP_001392676.1 1341020 R 5061 CDS An08g05600 84591685 complement(join(1342327..1342537,1342707..1342754,1342859..1342929)) VIII 1 NT_166524.1 hypothetical protein 1342929 84591685 An08g05600 Aspergillus niger hypothetical protein XP_059604053.1 1342327 R 5061 CDS An08g05610 4982877 complement(join(1343210..1344099,1344154..1344777,1344829..1345052,1345104..1345339,1345392..1345650,1345707..1345806,1345893..1346163)) VIII 1 NT_166524.1 Catalytic activity: NADPH + nitrate = NADP(+) + nitrite + H(2)O.; Gene-ID: niaD; Remark: the protein is necessary for nitrate assimilation.; cytoplasm; See PMID 1541396; See PMID 10846218; nitrate reductase (NADPH) niaD-Aspergillus niger 1346163 niaD 4982877 niaD Aspergillus niger nitrate reductase (NADPH) niaD-Aspergillus niger XP_001392678.1 1343210 R 5061 CDS An08g05620 84591686 join(1346262..1346311,1346387..1346450,1346488..1346553) VIII 1 NT_166524.1 hypothetical protein 1346553 84591686 An08g05620 Aspergillus niger hypothetical protein XP_059604054.1 1346262 D 5061 CDS An08g05630 84591687 complement(join(1346920..1347069,1347162..1347222,1347264..1347355,1347571..1347795)) VIII 1 NT_166524.1 hypothetical protein 1347795 84591687 An08g05630 Aspergillus niger hypothetical protein XP_059604055.1 1346920 R 5061 CDS An08g05640 4982880 join(1347832..1348004,1348078..1348228,1348321..1348860,1348916..1348998,1349050..1349565,1349627..1349829,1349881..1350353,1350417..1350574,1350630..1351626) VIII 1 NT_166524.1 Catalytic activity: 3 NAD(P)H + NITRITE = 3 NAD(P)(+) + NH(4)OH + H(2)O.; Remark: alternative splicing might occur; Remark: this protein is required for the assimilation of nitrate (denitrification).; Title: strong similarity to nitrite reductase (NADH) niiA - Aspergillus nidulans; cytoplasm; uncharacterized protein 1351626 4982880 An08g05640 Aspergillus niger uncharacterized protein XP_001392681.1 1347832 D 5061 CDS An08g05650 84591688 join(1351922..1352197,1352289..1352366,1352461..1352535,1352610..1352675,1352753..1352820,1352880..1352916) VIII 1 NT_166524.1 hypothetical protein 1352916 84591688 An08g05650 Aspergillus niger hypothetical protein XP_059604056.1 1351922 D 5061 CDS An08g05660 84591689 complement(join(1353195..1353392,1353676..1353810,1353874..1353993)) VIII 1 NT_166524.1 hypothetical protein 1353993 84591689 An08g05660 Aspergillus niger hypothetical protein XP_059604057.1 1353195 R 5061 CDS An08g05670 4982883 join(1354087..1354254,1354316..1354395,1354457..1354732,1354781..1355586,1355638..1355822) VIII 1 NT_166524.1 Remark: probably involved in extracellular nitrate uptake.; Title: strong similarity to nitrate permease crnA -Aspergillus nidulans; plasma membrane; See PMID 1986367; uncharacterized protein 1355822 4982883 An08g05670 Aspergillus niger uncharacterized protein XP_001392684.1 1354087 D 5061 CDS An08g05680 4982884 join(1357449..1357575,1357666..1357802,1357875..1357958) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein Cj0488 - Campylobacter jejuni; uncharacterized protein 1357958 4982884 An08g05680 Aspergillus niger uncharacterized protein XP_001392685.1 1357449 D 5061 CDS An08g05690 4982885 complement(join(1358228..1358685,1358736..1358796,1358854..1359678)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein CAD28429.1 - Aspergillus fumigatus; uncharacterized protein 1359678 4982885 An08g05690 Aspergillus niger uncharacterized protein XP_001392686.1 1358228 R 5061 CDS An08g05700 4982886 complement(join(1359874..1359984,1360085..1360151,1360335..1360601,1360656..1360718,1360770..1360938,1361080..1361245)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein SPCC1393.04 - Schizosaccharomyces pombe; uncharacterized protein 1361245 4982886 An08g05700 Aspergillus niger uncharacterized protein XP_001392687.3 1359874 R 5061 CDS An08g05710 84591690 complement(join(1361328..1361573,1361620..1361643)) VIII 1 NT_166524.1 hypothetical protein 1361643 84591690 An08g05710 Aspergillus niger hypothetical protein XP_059604058.1 1361328 R 5061 CDS An08g05720 4982888 join(1361733..1361786,1361842..1362535,1362633..1362769) VIII 1 NT_166524.1 Remark: C-terminus is 254 aa shorter than soluble epoxide hydrolase (SEH) from Homo sapiens.; Title: similarity to protein SEQ ID NO:1444 from patent WO200157190-A2 - Homo sapiens; uncharacterized protein 1362769 4982888 An08g05720 Aspergillus niger uncharacterized protein XP_001392689.3 1361733 D 5061 CDS An08g05730 4982889 join(1362868..1362870,1363059..1363096,1363163..1364024) VIII 1 NT_166524.1 Remark: yeast ribosomal protein L1 is required for the stability of newly synthesized 5S rRNA and the assembly of 60S ribosomal subunits.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L1 - Saccharomyces cerevisiae; cytoplasm; See PMID 8474444; 60S ribosomal protein uL18 1364024 4982889 An08g05730 Aspergillus niger 60S ribosomal protein uL18 XP_059604059.1 1362868 D 5061 CDS An08g05740 84591691 complement(join(1364339..1364503,1364601..1364807)) VIII 1 NT_166524.1 hypothetical protein 1364807 84591691 An08g05740 Aspergillus niger hypothetical protein XP_059604060.1 1364339 R 5061 CDS An08g05750 84591692 complement(join(1365714..1365765,1365846..1365914,1365953..1366065,1366361..1366504,1366671..1366780,1366868..1366961)) VIII 1 NT_166524.1 hypothetical protein 1366961 84591692 An08g05750 Aspergillus niger hypothetical protein XP_059604061.1 1365714 R 5061 CDS An08g05760 4982892 join(1367036..1367087,1367173..1370019,1370086..1370750) VIII 1 NT_166524.1 Remark: overexpression of NH2-terminal deleted MHP1 results in short spindles and disturbed nuclear migration.; Title: similarity to microtubule-interacting protein 1 Mhp1 - Saccharomyces cerevisiae; cytoskeleton; See PMID 8947554; uncharacterized protein 1370750 4982892 An08g05760 Aspergillus niger uncharacterized protein XP_059604062.1 1367036 D 5061 CDS An08g05770 84591693 join(1370790..1370904,1371028..1371102,1371146..1371177) VIII 1 NT_166524.1 hypothetical protein 1371177 84591693 An08g05770 Aspergillus niger hypothetical protein XP_059604063.1 1370790 D 5061 CDS An08g05780 4982894 join(1371510..1372019,1372086..1372722,1372786..1373683,1373756..1373831) VIII 1 NT_166524.1 Function: human ALDRP is a dimerization partner of adrenoleukodystrophy protein and other peroxisomal ABC-transporter.; Similarity: shows strong similarity to ALDRP of N. crassa and of other species.; Title: strong similarity to adrenoleukodystrophy related protein ALDRP - Homo sapiens; peroxisome; See PMID 10551832; uncharacterized protein 1373831 4982894 An08g05780 Aspergillus niger uncharacterized protein XP_001392695.1 1371510 D 5061 CDS An08g05790 4982895 complement(join(1374268..1374675,1374732..1376497,1376554..1376631,1376701..1376804,1376859..1376920,1376983..1377018,1377082..1377094,1377214..1377392)) VIII 1 NT_166524.1 Complex: homodimer in S. cerevisiae.; Function: glycogen phosphorylase catalyzes the conversion of (1,4-alpha-D-Glucosyl)n + phosphate = (1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate.; Title: strong similarity to glycogen phosphorylase Gph1 - Saccharomyces cerevisiae; cytoplasm; See PMID 3537803; See PMID 8703213; See PMID 1613787; uncharacterized protein 1377392 4982895 An08g05790 Aspergillus niger uncharacterized protein XP_001392696.1 1374268 R 5061 CDS An08g05800 84591694 complement(join(1377778..1378073,1378160..1378307,1378484..1378597)) VIII 1 NT_166524.1 hypothetical protein 1378597 84591694 An08g05800 Aspergillus niger hypothetical protein XP_059604064.1 1377778 R 5061 CDS An08g05810 84591695 complement(join(1378602..1378687,1378765..1378855)) VIII 1 NT_166524.1 hypothetical protein 1378855 84591695 An08g05810 Aspergillus niger hypothetical protein XP_059604065.1 1378602 R 5061 CDS An08g05820 4982898 complement(join(1379822..1379921,1379976..1380214,1380274..1380403,1380472..1380600,1380661..1381006,1381098..1381224)) VIII 1 NT_166524.1 Complex: G proteins contain three units (alpha, beta and gamma); the guanine nucleotide binding site is located in the alpha chain.; Similarity: shows strong similarity to G protein alpha subunit ganB of Emericella nidulans.; Title: strong similarity to G protein alpha subunit mod-D - Podospora anserina; See PMID 7939899; See PMID 10463328; uncharacterized protein 1381224 4982898 An08g05820 Aspergillus niger uncharacterized protein XP_001392699.1 1379822 R 5061 CDS An08g05830 84591696 join(1381410..1381441,1381528..1381707,1381755..1381862,1381918..1382009,1382137..1382287,1383653..1383811,1383904..1384038,1384561..1384648) VIII 1 NT_166524.1 hypothetical protein 1384648 84591696 An08g05830 Aspergillus niger hypothetical protein XP_059604066.1 1381410 D 5061 CDS An08g05840 84591697 complement(join(1384801..1384946,1385497..1385568,1385676..1385764,1385913..1385988,1386047..1386191)) VIII 1 NT_166524.1 Similarity: shows very weak similarity to pseudouridylate synthase yceC of Escherichia coli.; hypothetical protein 1386191 84591697 An08g05840 Aspergillus niger hypothetical protein XP_059604067.1 1384801 R 5061 CDS An08g05850 4982901 join(1386354..1386409,1386479..1386526,1386630..1386759,1386828..1386871,1386936..1387035,1387112..1387468,1387541..1387619,1387681..1387864,1387928..1388135) VIII 1 NT_166524.1 Function: OSM1 of P. grisea kinase is involved in arabitol accumulation.; Function: OSM1 of P. grisea regulates cellular turgor during hyperosmotic stress and appressorium-mediated plant infection.; Title: strong similarity to osomotic sensitivity MAP kinase OSM1 - Pyricularia grisea; See PMID 10521531; uncharacterized protein 1388135 4982901 An08g05850 Aspergillus niger uncharacterized protein XP_059604068.1 1386354 D 5061 CDS An08g05860 4982902 join(1389029..1389090,1389376..1389480,1389574..1389816,1389928..1389955,1390143..1390428,1390488..1390528,1390578..1390715,1390771..1392204) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein YLR114c - Saccharomyces cerevisiae; uncharacterized protein 1392204 4982902 An08g05860 Aspergillus niger uncharacterized protein XP_059604069.1 1389029 D 5061 CDS An08g05870 4982903 complement(join(1393032..1393220,1393284..1395319,1395424..1395550)) VIII 1 NT_166524.1 Function: human cullin-1 is involved in the SCF proteolytic pathway which is involved in regulation of the cell cycle.; Title: strong similarity to cullin 1 - Homo sapiens; See PMID 10508527; uncharacterized protein 1395550 4982903 An08g05870 Aspergillus niger uncharacterized protein XP_059604070.1 1393032 R 5061 CDS An08g05880 84591698 join(1395801..1395866,1396006..1396111,1396151..1396280,1396355..1396418) VIII 1 NT_166524.1 hypothetical protein 1396418 84591698 An08g05880 Aspergillus niger hypothetical protein XP_059604071.1 1395801 D 5061 CDS An08g05890 4982905 complement(join(1396473..1396551,1396622..1396672,1396731..1396863,1396993..1397247,1397333..1397496,1397911..1398862,1398938..1399109)) VIII 1 NT_166524.1 Function: Cdc 53 of S. cerevisiae is involved in targeting phosphorylated G1 cyclins for degradation by the ubiquitin proteolytic pathway.; Function: Cdc53p of S. cerevisiae functions as a noncatalytic scaffold protein bridging Cdc34p to Skp/F-box proteins.; Function: Cdc53p of S. cerevisiae is involved in G1/S transition control.; Function: Cdc53p of S. cerevisiae is involved in mitotic G1/S transition, mitotic G2/M transition and in ubiquitin-dependent protein degradation.; Title: similarity to cell cycle control protein Cdc53 - Saccharomyces cerevisiae; See PMID 8943317; See PMID 9312054; See PMID 9346239; uncharacterized protein 1399109 4982905 An08g05890 Aspergillus niger uncharacterized protein XP_059604072.1 1396473 R 5061 CDS An08g05900 4982906 join(1400049..1400485,1400570..1400625,1400687..1401024) VIII 1 NT_166524.1 Title: similarity to hypothetical protein encoded by SPAC23H3.12c - Schizosaccharomyces pombe; uncharacterized protein 1401024 4982906 An08g05900 Aspergillus niger uncharacterized protein XP_001392707.1 1400049 D 5061 CDS An08g05910 4982907 join(1401524..1401763,1401894..1402128,1402204..1402943) VIII 1 NT_166524.1 Function: End3p of S. cerevisiae is required for endocytosis and cytoskeletal organization.; Remark: mutation within sagA sensitises Aspergillus nidulans to alkylating agents.; Similarity: shows similarity to End3p of S. cerevisiae.; Title: strong similarity to protein SagA -Aspergillus nidulans; See PMID 10102359; See PMID 10594004; uncharacterized protein 1402943 4982907 An08g05910 Aspergillus niger uncharacterized protein XP_001392708.1 1401524 D 5061 CDS An08g05920 4982908 complement(join(1403504..1404367,1404594..1405187,1405250..1406107,1406188..1406397)) VIII 1 NT_166524.1 Function: Sth1p of S. cerevisiae is an essential gene encoding a component of a novel chromatin-remodeling complex RSC, alters the chromatin structure of S. cerevisiae centromeres.; Similarity: shows similarity to several Snf2p/Swi2p homologs of different species.; Title: similarity to Snf2p/Swi2p homolog Sth1 -Saccharomyces cerevisiae; nucleus; See PMID 9628931; See PMID 9799253; uncharacterized protein 1406397 4982908 An08g05920 Aspergillus niger uncharacterized protein XP_059604073.1 1403504 R 5061 CDS An08g05930 84591699 complement(join(1407432..1407483,1407566..1407648)) VIII 1 NT_166524.1 hypothetical protein 1407648 84591699 An08g05930 Aspergillus niger hypothetical protein XP_059604074.1 1407432 R 5061 CDS An08g05940 84591700 1407726..1409219 VIII 1 NT_166524.1 Title: similarity to hypothetical protein encoded by An12g01470 - Aspergillus niger; uncharacterized protein 1409219 84591700 An08g05940 Aspergillus niger uncharacterized protein XP_059604075.1 1407726 D 5061 CDS An08g05950 4982911 complement(join(1409440..1410735,1410798..1410974)) VIII 1 NT_166524.1 Catalytic activity: dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil + H2O = 3-ureidopropionate.; Function: the Saccharomyces kluyveri dihydropyrimidinase is capable of catalysing both dihydrouracil and dihydrothymine degradation.; Pathway: regulatory checkpoint of the pyrimidine catabolic pathway.; Title: strong similarity to dihydropyrimidinase Pyd2 - Saccharomyces kluyveri; See PMID 10574455; See PMID 10656811; uncharacterized protein 1410974 4982911 An08g05950 Aspergillus niger uncharacterized protein XP_001392712.1 1409440 R 5061 CDS An08g05960 84591701 complement(join(1412943..1414421,1414503..1415000)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein CAD28445.1 - Aspergillus fumigatus; uncharacterized protein 1415000 84591701 An08g05960 Aspergillus niger uncharacterized protein XP_059604076.1 1412943 R 5061 CDS An08g05970 4982913 complement(1415541..1416476) VIII 1 NT_166524.1 Title: strong similarity to hypothetical dual specificity protein phosphatase 3 CAD28446.1 - Aspergillus fumigatus; uncharacterized protein 1416476 4982913 An08g05970 Aspergillus niger uncharacterized protein XP_001392714.1 1415541 R 5061 CDS An08g05980 84591702 join(1417341..1417479,1417548..1417645) VIII 1 NT_166524.1 hypothetical protein 1417645 84591702 An08g05980 Aspergillus niger hypothetical protein XP_059604077.1 1417341 D 5061 CDS An08g06010 84591703 complement(join(1419802..1419834,1419888..1419950,1420263..1420289)) VIII 1 NT_166524.1 Title: questionable ORF; uncharacterized protein 1420289 84591703 An08g06010 Aspergillus niger uncharacterized protein XP_059604078.1 1419802 R 5061 CDS An08g06030 4982919 complement(join(1422825..1423285,1423365..1423411,1423469..1423731)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical zinc-finger transcription factor CAD28447.1 - Aspergillus fumigatus; uncharacterized protein 1423731 4982919 An08g06030 Aspergillus niger uncharacterized protein XP_059604079.1 1422825 R 5061 CDS An08g06040 84591704 join(1423831..1423917,1423959..1424071,1424435..1424485,1424535..1424707,1424780..1424837,1425112..1425202) VIII 1 NT_166524.1 hypothetical protein 1425202 84591704 An08g06040 Aspergillus niger hypothetical protein XP_059604080.1 1423831 D 5061 CDS An08g06050 4982921 complement(join(1427129..1430147,1430207..1430406)) VIII 1 NT_166524.1 Function: UPF1 of S. cerevisiae is involved in modulating both translation termination and mRNA turnover.; Function: UPF1 of S. cerevisiae is required for rapid turnover of cytoplasmic mRNA with a premature termination codon; Remark: UPF1, MOF4 and YMR080c are alternative names for NAM7 of S. cerevisiae.; Similarity: UPF1 of S. cerevisiae is a member of the superfamily group I helicases.; Title: strong similarity to prematurely terminated mRNA decay factor Nam7 - Saccharomyces cerevisiae; cytoplasm; See PMID 1314899; See PMID 1569946; uncharacterized protein 1430406 4982921 An08g06050 Aspergillus niger uncharacterized protein XP_001392719.1 1427129 R 5061 CDS An08g06060 4982922 join(1431046..1431051,1431131..1432018) VIII 1 NT_166524.1 Function: the S. cerevisiae Imp4 protein is a component of the U3 small nucleolar ribonucleoprotein (U3 snoRNP). It interacts physically with the U3 snoRNP specific protein, Mpp10. It is required for the early cleavages at sites A0, A1 and A2 of the pre ribosomal RNA to yield pre 18s ribosomal RNA processing.; Remark: alternate name for S. cerevisiae Imp4: YNL075W.; Title: strong similarity to component of the U3 snoRNP Imp4 - Saccharomyces cerevisiae; nucleus; See PMID 10409734; uncharacterized protein 1432018 4982922 An08g06060 Aspergillus niger uncharacterized protein XP_001392720.1 1431046 D 5061 CDS An08g06070 4982923 complement(join(1432295..1432810,1432919..1433001,1433086..1433151,1433269..1433466,1433573..1433747)) VIII 1 NT_166524.1 Remark: all blastp matches are about 3 times longer than the A. niger protein.; Title: weak similarity to NAD+ ADP-ribosyltransferase PPOL - Homo sapiens; uncharacterized protein 1433747 4982923 An08g06070 Aspergillus niger uncharacterized protein XP_059604081.1 1432295 R 5061 CDS An08g06080 4982924 complement(1434197..1436509) VIII 1 NT_166524.1 Catalytic activity: TrpC catalyzes the the glutamine amidotransferase reaction (GAT), the indole-3-glycerol phosphate synthase reaction (IGPS) and the N-(5'-phosphoribosyl) anthranilate isomerase reaction (PRAI), respectively.; Gene-ID: trpC; Pathway: Trp C is involved in the tryptophan biosynthesis.; cytoplasm; See PMID 2936650; anthranilate synthase multifunctional protein trpC-Aspergillus niger 1436509 trpC 4982924 trpC Aspergillus niger anthranilate synthase multifunctional protein trpC-Aspergillus niger XP_001392722.1 1434197 R 5061 CDS An08g06090 4982925 join(1436984..1437051,1437116..1441190,1441246..1442601) VIII 1 NT_166524.1 Phenotype: Deltanup184 mutations confer sensitivity to growth in nutrient-rich medium (YES) that is accompanied by nuclear poly(A)+ RNA accumulation.; Phenotype: nup184 of S. pombe is synthetically lethal with the mRNA export defective rae1-167 mutation. The consequence of the synthetic lethality is a defect in mRNA export.; Title: similarity to nucleoporin nup184p -Schizosaccharomyces pombe; nucleus; See PMID 10388805; uncharacterized protein 1442601 4982925 An08g06090 Aspergillus niger uncharacterized protein XP_059604082.1 1436984 D 5061 CDS An08g06100 4982926 join(1444248..1445308,1445392..1445680,1445802..1445905,1445968..1446202) VIII 1 NT_166524.1 Catalytic activity: 4CL-1 of P. crispum catalyzes the reaction ATP + 4-coumarate + CoA <=> AMP + diphosphate + 4-coumaroyl-CoA.; Pathway: plant 4CL-1 is involved in the biosynthesis of lignin.; Remark: fungi are known to use lignin as a carbon source.; Title: similarity to 4-coumarate-CoA ligase 4CL1 -Petroselinum crispum; See PMID 3169018; uncharacterized protein 1446202 4982926 An08g06100 Aspergillus niger uncharacterized protein XP_001392724.1 1444248 D 5061 CDS An08g06110 84591705 complement(join(1446640..1446713,1446874..1446943,1447450..1447501,1447647..1447841,1448174..1448181)) VIII 1 NT_166524.1 hypothetical protein 1448181 84591705 An08g06110 Aspergillus niger hypothetical protein XP_059604083.1 1446640 R 5061 CDS An08g06120 10098015 join(1448914..1449525,1449561..1449579,1450129..1450310,1450423..1450617) VIII 1 NT_166524.1 Title: similarity to hypothetical protein EAA65426.1 - Aspergillus nidulans; uncharacterized protein 1450617 10098015 An08g06120 Aspergillus niger uncharacterized protein XP_059604084.1 1448914 D 5061 CDS An08g06125 84591706 complement(1451058..1451483) VIII 1 NT_166524.1 hypothetical protein 1451483 84591706 An08g06125 Aspergillus niger hypothetical protein XP_059604085.1 1451058 R 5061 CDS An08g06130 4982930 complement(join(1452267..1452310,1452370..1452926,1452984..1453326,1453402..1453519)) VIII 1 NT_166524.1 Function: activation of fadA from A. nidulans leads to proliferation and blocks sporulation.; Title: strong similarity to GTP-binding regulatory protein alpha chain fadA - Aspergillus nidulans; See PMID 8895563; See PMID 10947863; uncharacterized protein 1453519 4982930 An08g06130 Aspergillus niger uncharacterized protein XP_001392728.1 1452267 R 5061 CDS An08g06140 84591707 complement(join(1454541..1454673,1454723..1454811,1455010..1455333,1455695..1455755,1455851..1455963,1456175..1456302,1456401..1456553,1456650..1456704)) VIII 1 NT_166524.1 hypothetical protein 1456704 84591707 An08g06140 Aspergillus niger hypothetical protein XP_059604086.1 1454541 R 5061 CDS An08g06150 4982932 join(1456789..1456829,1457052..1457166,1457388..1457717,1457972..1458222,1458317..1458731) VIII 1 NT_166524.1 Title: similarity to hypothetical conserved protein SPAC11H11.03c - Schizosaccharomyces pombe; uncharacterized protein 1458731 4982932 An08g06150 Aspergillus niger uncharacterized protein XP_059604087.1 1456789 D 5061 CDS An08g06160 4982933 complement(join(1459203..1459950,1460017..1460438)) VIII 1 NT_166524.1 Catalytic activity: Trans-trans-farnesyl diphosphate + isopentenyl diphosphate <=> diphosphate + geranylgeranyl diphosphate.; Function: al-3 from N. crassa is involved in carotinoid biosynthesis.; Remark: Farnesyltranstransferase is synonymous for geranylgeranyl pyrophosphate synthetase.; Title: strong similarity to geranylgeranyl pyrophosphate synthase al-3 - Neurospora crassa; See PMID 1826006; See PMID 9017926; uncharacterized protein 1460438 4982933 An08g06160 Aspergillus niger uncharacterized protein XP_001392731.1 1459203 R 5061 CDS An08g06170 4982934 join(1461707..1461962,1462027..1462661) VIII 1 NT_166524.1 Function: in S. cerevisiae Cdc15 serves both as an activator and substrate of Cdc14.; Function: inactivation of mitotic cyclin-dependent kinases (Cdks) is required for cells to exit mitosis. in S. cerevisiae, Cdk inactivation is triggered by the phosphatase Cdc14.; Regulation: the S. cerevisiae phosphatase Cdc14 is activated by a complex network of regulatory proteins that includes the protein kinase Cdc15.; Title: similarity to cell division control protein cdc14p - Schizosaccharomyces pombe; nucleus; See PMID 8334307; See PMID 10600711; uncharacterized protein 1462661 4982934 An08g06170 Aspergillus niger uncharacterized protein XP_001392732.1 1461707 D 5061 CDS An08g06180 4982935 complement(join(1463159..1463202,1463255..1463506,1463581..1463786,1463868..1464198,1464300..1464390,1464452..1464848,1464914..1465134)) VIII 1 NT_166524.1 Function: 6-HDNO of A. oxidans oxidizes 6-hydroxy-D-nicotine to 6-hydroxy-N-methylmyosmine.; Title: similarity to 6-hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 3622516; uncharacterized protein 1465134 4982935 An08g06180 Aspergillus niger uncharacterized protein XP_059604088.1 1463159 R 5061 CDS An08g06190 4982936 join(1465559..1465657,1465733..1465798,1465851..1465955,1466003..1466244,1466289..1466381,1466511..1466553) VIII 1 NT_166524.1 Function: it has been suggested that Pth11p is not required for appressorium morphogenesis but is involved in host surface recognition.; Function: mutations in PTH11 of M. grisea cause a defect in appressorium differentiation.; Remark: Pth11p of M. grisea is C-terminal 400 aa longer.; Title: similarity to PTH11 - Magnaporthe grisea; uncharacterized protein 1466553 4982936 An08g06190 Aspergillus niger uncharacterized protein XP_059604089.1 1465559 D 5061 CDS An08g06200 4982937 complement(join(1467363..1467758,1467835..1468074,1468154..1468586,1468869..1469130,1469196..1469265)) VIII 1 NT_166524.1 Function: human Metaxin participates in preprotein import into mitochondria.; Remark: N-terminal 200 aa show no similarity to human Metaxin.; Title: similarity to mitochondrial import protein Metaxin - Homo sapiens; localisation:mitochondrion; See PMID 11027586; uncharacterized protein 1469265 4982937 An08g06200 Aspergillus niger uncharacterized protein XP_001392735.3 1467363 R 5061 CDS An08g06210 4982938 join(1469486..1469594,1469705..1471101) VIII 1 NT_166524.1 Function: in P. anserina the transcription factor Grisea controls expression of the mitochondrial manganese superoxide dismutase (PaSOD2).; Title: similarity to transcription factor grisea -Podospora anserina; See PMID 11134328; uncharacterized protein 1471101 4982938 An08g06210 Aspergillus niger uncharacterized protein XP_059604090.1 1469486 D 5061 CDS An08g06220 4982939 complement(1471779..1472051) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein SPAPJ691.03 - Schizosaccharomyces pombe; uncharacterized protein 1472051 4982939 An08g06220 Aspergillus niger uncharacterized protein XP_001392737.3 1471779 R 5061 CDS An08g06230 4982940 join(1472711..1472728,1472821..1477257) VIII 1 NT_166524.1 Remark: similarity is confined to C-terminal region.; Title: similarity to hypothetical membrane protein YJR041c - Saccharomyces cerevisiae; uncharacterized protein 1477257 4982940 An08g06230 Aspergillus niger uncharacterized protein XP_001392738.1 1472711 D 5061 CDS An08g06240 4982941 join(1479660..1479759,1479878..1479948,1480032..1480281,1480354..1481081,1481141..1481674) VIII 1 NT_166524.1 Function: the transport of uracil into the yeast S. pombe is mediated by uracil permease, a specific co-transporter encoded by the FUR4 gene.; Title: strong similarity to uracil transport protein fur4p - Schizosaccharomyces pombe; plasma membrane; See PMID 9730284; See PMID 10085225; uncharacterized protein 1481674 4982941 An08g06240 Aspergillus niger uncharacterized protein XP_001392739.1 1479660 D 5061 CDS An08g06250 4982942 join(1483233..1483350,1483507..1484819) VIII 1 NT_166524.1 Catalytic activity: Benzoate + NADPH + O(2) <=> 4-hydroxybenzoate + NADP(+) + H(2)O.; Induction: bphA of A. niger is inducible by benzoate.; Pathway: bphA of A. niger is an enzyme in the phenylalanine metabolism.; Similarity: bphA from A. niger is a member of a new gene family of the cytochrome P450 superfamily.; Title: strong similarity to benzoate 4-monooxygenase cytochrome P450 53 bphA - Aspergillus niger; endoplasmatic reticulum; See PMID 2250647; See PMID 10852481; uncharacterized protein 1484819 4982942 An08g06250 Aspergillus niger uncharacterized protein XP_059604091.1 1483233 D 5061 CDS An08g06260 4982943 1485272..1488010 VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein AAO49461.1 - Leptosphaeria maculans; uncharacterized protein 1488010 4982943 An08g06260 Aspergillus niger uncharacterized protein XP_001392741.1 1485272 D 5061 CDS An08g06270 4982944 complement(join(1488116..1488307,1488383..1489061,1489126..1489268,1489376..1489432)) VIII 1 NT_166524.1 Catalytic activity: Adenosine + H(2)O <=> inosine + NH(3).; Title: similarity to adenosine deaminase - Mus musculus; See PMID 2410423; uncharacterized protein 1489432 4982944 An08g06270 Aspergillus niger uncharacterized protein XP_001392742.1 1488116 R 5061 CDS An08g06280 84591708 join(1490880..1490977,1491091..1491358) VIII 1 NT_166524.1 hypothetical protein 1491358 84591708 An08g06280 Aspergillus niger hypothetical protein XP_059604092.1 1490880 D 5061 CDS An08g06290 84591709 complement(join(1494587..1494725,1494934..1495058)) VIII 1 NT_166524.1 hypothetical protein 1495058 84591709 An08g06290 Aspergillus niger hypothetical protein XP_059604093.1 1494587 R 5061 CDS An08g06300 84591710 complement(join(1495524..1495817,1495882..1495957,1496587..1496668,1496755..1496889,1497354..1497444)) VIII 1 NT_166524.1 Remark: defined as questionable ORF as Introns are much larger than Exons.; Title: questionable ORF; uncharacterized protein 1497444 84591710 An08g06300 Aspergillus niger uncharacterized protein XP_059604094.1 1495524 R 5061 CDS An08g06310 84591711 complement(join(1497779..1497900,1498095..1498143,1498320..1498514,1498701..1498814,1498993..1499130,1499500..1499622,1499673..1499790,1499984..1500074,1500120..1500132)) VIII 1 NT_166524.1 hypothetical protein 1500132 84591711 An08g06310 Aspergillus niger hypothetical protein XP_059604095.1 1497779 R 5061 CDS An08g06320 4982949 1502785..1506255 VIII 1 NT_166524.1 Catalytic activity: 1-phosphatidyl-1D-myo-inositol 4, 5-bisphosphate + H(2) <=> D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.; Function: Plc1 from S. pombe is a 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase.; Function: activated by all classes of cell surface receptors, Plc proteins generate the ubiquitous second messengers inositol 1,4,5-trisphosphate and diacylglycerol.; Similarity: C-terminal 200 aa longer than similar proteins.; Title: similarity to phosphoinositide-specific phospholipase C lc1p - Schizosaccharomyces pombe; See PMID 11015615; See PMID 7732727; uncharacterized protein 1506255 4982949 An08g06320 Aspergillus niger uncharacterized protein XP_001392747.1 1502785 D 5061 CDS An08g06330 4982950 join(1507555..1508045,1508126..1508261,1508347..1508585,1508665..1508773) VIII 1 NT_166524.1 Function: epsilon-COP together with other COP-subunits assembels into the coatomer, which participates in intracellular vesicle formation and membrane transport.; Title: strong similarity to epsilon-COP - Cricetulus griseus; intracellular transport vesicles; See PMID 8626666; See PMID 10449336; uncharacterized protein 1508773 4982950 An08g06330 Aspergillus niger uncharacterized protein XP_059604096.1 1507555 D 5061 CDS An08g06340 4982951 complement(join(1509230..1509364,1509482..1510068,1510149..1510294,1510348..1510547)) VIII 1 NT_166524.1 Function: chnC from Acinetobacter catalyzes conversion of caprolactone to 6-hydroxyhexanoic acid in the cyclohexanol oxidation pathway.; Title: strong similarity to acetyl-hydrolase chnC -Acinetobacter sp.; See PMID 10940013; uncharacterized protein 1510547 4982951 An08g06340 Aspergillus niger uncharacterized protein XP_001392749.1 1509230 R 5061 CDS An08g06350 4982952 complement(join(1510868..1511865,1511921..1512158,1512217..1512308,1512368..1512388,1512467..1512497)) VIII 1 NT_166524.1 Catalytic activity: D-mannose 6-phosphate <=> D-fructose 6-phosphate.; Function: a temperature-sensitive pmi40-1 mutant of S. cerevisiae is defective in glycosylation and secretion.; Remark: protein is involved in the synthesis of GDP-mannose and dolichol-phosphate mannose in mannosyl transfer reactions in the glycosylation and mannosylation pathways.; Title: strong similarity to mannose-6-phosphate isomerase Pmi40 - Saccharomyces cerevisiae; cytoplasm; See PMID 1377774; uncharacterized protein 1512497 4982952 An08g06350 Aspergillus niger uncharacterized protein XP_001392750.1 1510868 R 5061 CDS An08g06360 4982953 join(1512892..1513543,1513837..1514368,1514427..1514670,1514710..1514775) VIII 1 NT_166524.1 Similarity: An08g06360 is N-terminal 300 aa longer.; Title: similarity to hypothetical protein SPBC21D10.13 - Schizosaccharomyces pombe; uncharacterized protein 1514775 4982953 An08g06360 Aspergillus niger uncharacterized protein XP_059604097.1 1512892 D 5061 CDS An08g06370 4982954 join(1515570..1516778,1516912..1516920) VIII 1 NT_166524.1 Catalytic activity: RIB1 from P. guilliermondii catalyses the release of formate and inorganic pyrophosphate under formation of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidine 5'-phosphate from GTP.; Function: RIB1 from P. guilliermondii is involved in riboflavin (vitamin B2) biosynthesis.; Title: strong similarity to GTP-cyclohydrolase II RIB1 - Pichia guilliermondii; See PMID 3891906; See PMID 8533469; uncharacterized protein 1516920 4982954 An08g06370 Aspergillus niger uncharacterized protein XP_059604098.1 1515570 D 5061 CDS An08g06380 4982955 join(1518106..1518679,1518746..1519839) VIII 1 NT_166524.1 Title: strong similarity to putative transcription factor CAF32051.1 - Aspergillus fumigatus; uncharacterized protein 1519839 4982955 An08g06380 Aspergillus niger uncharacterized protein XP_001392753.1 1518106 D 5061 CDS An08g06390 4982956 complement(join(1520573..1520840,1520909..1521046,1521127..1521458,1521557..1521745,1521811..1521828)) VIII 1 NT_166524.1 Catalytic activity: 3-hydroxy-2-methylpropanoate + NAD(+) <=> 2-methyl-3-oxopropanoate + NADH.; Function: mmsB from P. aeruginosa takes part in the valine degradation pathway.; Title: similarity to 3-hydroxyisobutyrate dehydrogenase mmsB - Pseudomonas aeruginosa; See PMID 1339433; uncharacterized protein 1521828 4982956 An08g06390 Aspergillus niger uncharacterized protein XP_001392754.1 1520573 R 5061 CDS An08g06400 4982957 join(1522526..1522544,1522667..1522713,1522778..1522921,1523032..1523257,1523330..>1523916) VIII 1 NT_166524.1 Complex: Arp2p from S. pombe forms a complex with Arp3p and actin.; Function: in S. pombe mutant analysis led to the hypothesis that loss of Arp2p from the actin patch affects patch motility but does not severely compromise its architecture.; Function: the Arp2/3 complex is a multi-functional protein complex that nucleates and crosslinks actin filaments.; Remark: ORF C-terminally truncated due to end of contig.; Title: strong similarity to actin-related protein arp2p - Schizosaccharomyces pombe [truncated ORF]; cytoskeleton; See PMID 10611965; uncharacterized protein 1523916 4982957 An08g06400 Aspergillus niger uncharacterized protein XP_001392755.3 1522526 D 5061 CDS An08g06410 84591712 join(<1524057..1524134,1524220..1524306) VIII 1 NT_166524.1 Complex: Arp2 of S. cerevisiae is subunit of the Arp2/3 protein complex which is conserved from yeast to man.; Complex: in S. cerevisiae the complex is composed of the subunits Arp2p, Arp3p, Arc15p, Arc18p, Arc19p,Arc35p.; Function: the Arp2/3p complex of S. cervevisiae is involved in the nucleation step of actin filament assembly and in the formation of endocytic vesicles.; Function: the Arp2/3p complex of S. cervevisiae is required for the motility and integrity of cortical actin patches.; Localization: the Arp2/3 complex in S. cerevisiae localizes to cortical actin patches.; Remark: ARP2 of S. cerevisiae was formerly designated ACT2, its systematic genename is YDL029W.; Remark: ORF is N-terminally truncated due to contig border.; Title: strong similarity to actin-like protein Arp2 - Saccharomyces cerevisiae [truncated ORF]; cytoskeleton; See PMID 9243513; See PMID 10377407; See PMID 11278164; uncharacterized protein 1524306 84591712 An08g06410 Aspergillus niger uncharacterized protein XP_059604099.1 1524057 D 5061 CDS An08g06420 4982959 complement(join(1525009..1525268,1525344..1526098,1526174..1526493)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein SPBC405.03c - Schizosaccharomyces pombe; uncharacterized protein 1526493 4982959 An08g06420 Aspergillus niger uncharacterized protein XP_001392757.3 1525009 R 5061 CDS An08g06430 4982960 complement(join(1527535..1527749,1527831..1527959,1528025..1528214,1528274..1528359,1528429..1528589,1528651..1528757,1528809..1528982,1529036..1529253,1529320..1529370,1529419..1529503,1529559..1529888)) VIII 1 NT_166524.1 Remark: the systematic genename of S. cerevisiae DAL5 is YJR152W.; Similarity: shows to several members of the DAL family of transporters of S. cerevisiae.; Similarity: the Dal family proteins of S. cerevisiae are weakly similar to bacterial (hypothetical) permeases for tartrate (ttuB), 4-hydroxyphenylacetate (hpaX),phtalate (Pht1), suggesting that proteins of the Dal family correspond to permeases for carboxylic acids.; Title: similarity to allantoate permease Dal5 -Saccharomyces cerevisiae; See PMID 3275614; See PMID 10869563; uncharacterized protein 1529888 4982960 An08g06430 Aspergillus niger uncharacterized protein XP_059604100.1 1527535 R 5061 CDS An08g06440 4982961 complement(join(1531127..1531644,1531719..1532253)) VIII 1 NT_166524.1 Function: aflatoxin B1-aldehyde reductases (AFAR) catalyzes the NADPH-dependent reduction of the dialdehyde to a dialcohol.; Function: oxidation of the mycotoxin aflatoxin (AF) B(1) yields the 8,9-epoxide, which nonenzymatically hydrolyzes rapidly to a dihydrodiol that in turn undergoes slow, base-catalyzed ring opening to a dialdehyde.; Remark: a splice site was detected upstream of the START codon.; Remark: the androgen-inducible aldehyde reductase aiar of rat is closely related to aflatoxin, B1 aldehyde reductase.; Similarity: shows similarity to bacterial and plant potassium channel beta subunits and to several bacterial putative dehydrogenesases and oxidoreductases.; Similarity: shows strong similarity to human and rat aflatoxin B1-aldehyde reductases.; Title: strong similarity to androgen-inducible aldehyde reductase aiar - Rattus norvegicus; See PMID 10965890; See PMID 11409944; uncharacterized protein 1532253 4982961 An08g06440 Aspergillus niger uncharacterized protein XP_001392759.1 1531127 R 5061 CDS An08g06450 4982962 join(1532858..1533290,1533327..1533742) VIII 1 NT_166524.1 Function: hydantoin racemase of A. aurescens is involved in the complete conversion of slowly racemizing 5'-monosubstituted D,L-hydantoins to L-amino acids.; Similarity: shows similarity to nitrogen-catabolite repression sensitive DCG1 of S. cerevisisae.; Title: similarity to hydantoin racemase hyuA -Arthrobacter aurescens; uncharacterized protein 1533742 4982962 An08g06450 Aspergillus niger uncharacterized protein XP_059604101.1 1532858 D 5061 CDS An08g06460 4982963 join(1534098..1534136,1534327..1534387,1534482..1534594,1534657..1534710,1534791..1534973,1535062..1535265,1535323..1535409,1535457..1536134) VIII 1 NT_166524.1 Function: cytoplasmic gamma-tubulin complexes are targeted to centrosomes or to other microtubule organizing centers (MTOCs) via a set of so called gamma-tubulin complex binding proteins (GTBPs) that probably interact with the conserved Spc97p/Spc98p protein family of gamma-tubulin complexes.; Function: microtubule assembly is initiated in vivo by gamma-tubulin complexes.; Title: strong similarity to gamma-tubulin mipA -Aspergillus nidulans; centrosome; See PMID 2194669; See PMID 10679351; See PMID 11005014; uncharacterized protein 1536134 4982963 An08g06460 Aspergillus niger uncharacterized protein XP_059604102.1 1534098 D 5061 CDS An08g06470 84591713 complement(join(1536925..1537130,1537358..1537414,1537462..1537604,1537761..1537768)) VIII 1 NT_166524.1 hypothetical protein 1537768 84591713 An08g06470 Aspergillus niger hypothetical protein XP_059604103.1 1536925 R 5061 CDS An08g06485 84591714 1540763..1541011 VIII 1 NT_166524.1 hypothetical protein 1541011 84591714 An08g06485 Aspergillus niger hypothetical protein XP_059604104.1 1540763 D 5061 CDS An08g06490 4982966 complement(join(1541323..1541462,1541692..1541797,1541845..1541854,1541901..1541998,1542211..1542504)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein EAA65454.1 - Aspergillus nidulans; uncharacterized protein 1542504 4982966 An08g06490 Aspergillus niger uncharacterized protein XP_059604105.1 1541323 R 5061 CDS An08g06500 4982967 complement(1543071..1544330) VIII 1 NT_166524.1 Similarity: shows similarity to several putative and known phosphotyrosyl phosphatase activators.; Title: strong similarity to phosphotyrosyl phosphatase activator PTPA - Homo sapiens; uncharacterized protein 1544330 4982967 An08g06500 Aspergillus niger uncharacterized protein XP_001392765.1 1543071 R 5061 CDS An08g06510 84591715 complement(join(1545789..1546019,1546419..1546478,1546633..1546812,1547008..1547160)) VIII 1 NT_166524.1 hypothetical protein 1547160 84591715 An08g06510 Aspergillus niger hypothetical protein XP_059604106.1 1545789 R 5061 CDS An08g06520 4982969 1548918..1551638 VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein BX649606_96 - Aspergillus fumigatus; uncharacterized protein 1551638 4982969 An08g06520 Aspergillus niger uncharacterized protein XP_001392767.1 1548918 D 5061 CDS An08g06530 4982970 join(1552633..1553948,1554190..1554340) VIII 1 NT_166524.1 Title: similarity to hypothetical protein YLR063w -Saccharomyces cerevisiae; uncharacterized protein 1554340 4982970 An08g06530 Aspergillus niger uncharacterized protein XP_059604107.1 1552633 D 5061 CDS An08g06540 4982971 complement(join(1554380..1554898,1554967..1555287)) VIII 1 NT_166524.1 Function: prohibitin of S. cerevisiae and other organisms acts as a membrane-bound chaperone for the stabilization of mitochondrial proteins.; Function: prohibitin of S. cerevisiae is an antiproliferative protein involved in determination of replicative life span and ageing.; Title: strong similarity to antiproliferative protein prohibitin Phb1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 8810036; See PMID 9259555; See PMID 9632789; See PMID 10197723; See PMID 10207067; uncharacterized protein 1555287 4982971 An08g06540 Aspergillus niger uncharacterized protein XP_001392769.1 1554380 R 5061 CDS An08g06550 4982972 join(1555569..1555600,1555783..1555808,1555999..1556176,1556274..1556328) VIII 1 NT_166524.1 Catalytic activity: QH2 + 2 Ferricytochrome c = Q + 2 Ferrocytochrome c.; Pathway: ubiquinol cytochrome c reductase, also called complex III, is part of the mitochondrial respiratory chain.; Remark: subunit VIII of the S. cerevisiae cytochrome bc1 complex interacts with succinate-ubiquinone reductase and might be responsible for electron transfer from succinate to ubiquinone.; Title: strong similarity to subunit VIII of ubiquinol--cytochrome c reductase - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 2170131; See PMID 3036507; See PMID 8212892; See PMID 8394810; See PMID 1317009; uncharacterized protein 1556328 4982972 An08g06550 Aspergillus niger uncharacterized protein XP_001392770.1 1555569 D 5061 CDS An08g06560 4982973 join(1557294..1557324,1557562..1557742,1557815..1557962,1558033..1558270,1558483..1558763) VIII 1 NT_166524.1 Catalytic activity: S-Adenosylmethioninamine + Putrescine = 5'-Methylthioadenosine + Spermidine.; Pathway: spermidine sinthase catalyzes the third step of polyamine biosynthesis.; Title: strong similarity to spermidine synthase Spe3 - Saccharomyces cerevisiae; See PMID 6754461; See PMID 6991493; See PMID 7040829; See PMID 8961564; See PMID 9073064; uncharacterized protein 1558763 4982973 An08g06560 Aspergillus niger uncharacterized protein XP_059604108.1 1557294 D 5061 CDS An08g06570 4982974 complement(join(1559330..1559443,1559506..1560869,1560937..1561231,1561299..1561383,1561444..1561586,1561855..1561908)) VIII 1 NT_166524.1 Catalytic activity: transketolase 1 converts sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate to D-ribose 5-phosphate + D-xylulose 5-phosphate.; Function: TKL1 of S. cerevisiae is required for biosynthesis of erythrose-4-phosphate which is needed for biosynthesis of aromatic amino acids.; Pathway: TKL1 of S. cerevisiae is part of the pentose phosphate pathway.; Title: strong similarity to transketolase Tkl1 -Saccharomyces cerevisiae; cytoplasm; See PMID 8226984; See PMID 8299150; See PMID 8534086; See PMID 8910528; See PMID 9398292; uncharacterized protein 1561908 4982974 An08g06570 Aspergillus niger uncharacterized protein XP_001392772.1 1559330 R 5061 CDS An08g06580 4982975 complement(join(1564421..1565575,1565633..1565990,1566048..1566328,1566386..1566696,1566805..1567288)) VIII 1 NT_166524.1 Function: facB from A. niger complements the acuB mutant phenotype; acuB mutants lacked both acetyl-CoA synthetase and isocitrate lyase activity.; Gene-ID: facB; Remark: facB from A. niger is probably the regulatory gene for acetate induction.; Similarity: facB from A. niger was identified by cross-hybridisation of an A. nidulans facB clone.; nucleus; See PMID 9197408; See PMID 9695922; See PMID 10483720; acetate regulatory DNA binding protein facB-Aspergillus niger 1567288 facB 4982975 facB Aspergillus niger acetate regulatory DNA binding protein facB-Aspergillus niger XP_001392773.1 1564421 R 5061 CDS An08g06590 4982976 complement(join(1571126..1571206,1571327..1571918,1571979..1572505,1572614..1572910)) VIII 1 NT_166524.1 Function: rbcL of S. oleracea is involved in the methylation of the alpha-amino group of the N-terminal methionine of the processed form of the small subunit of the enzyme ribulose-1,5-bisphosphate carboxylase/oxigenase (Rubisco).; Similarity: the predicted protein shows similarity to different known and putative protein N-methyltransferases of plants.; Title: similarity to ribulose-1,5-bisphosphate carboxylase/oxygenase small subunit N-methyltransferase I rbcL - Spinacia oleracea; See PMID 10593982; uncharacterized protein 1572910 4982976 An08g06590 Aspergillus niger uncharacterized protein XP_059604109.1 1571126 R 5061 CDS An08g06600 4982977 join(1573317..1573721,1573778..1573894) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein CAF32076.1 - Aspergillus fumigatus; uncharacterized protein 1573894 4982977 An08g06600 Aspergillus niger uncharacterized protein XP_059604110.1 1573317 D 5061 CDS An08g06610 4982978 complement(join(1573974..1574000,1574059..1574179,1574232..1574411,1574466..1574671,1574730..1574941,1574997..1575028,1575077..1575170,1575238..1575506,1575605..1575614,1575683..1575740,1575800..1575835)) VIII 1 NT_166524.1 Similarity: the predicted protein has the same length and a similarity > 75% with yeast hypothetical proteins.; Similarity: the predicted protein shows some structural features and a moderate similarity to hypothetical proteins annotated as GTP-binding proteins due to the similarity to E. coli ychF, whose function, anyway,was not experimentally verified.; Title: similarity to hypothetical GTP-binding protein ychF - Escherichia coli; See PMID 7828865; See PMID 9298646; See PMID 1833189; uncharacterized protein 1575835 4982978 An08g06610 Aspergillus niger uncharacterized protein XP_001392776.1 1573974 R 5061 CDS An08g06620 4982979 join(1577287..1577400,1577456..1577770) VIII 1 NT_166524.1 Title: similarity to hypothetical protein CAF32078.1 - Aspergillus fumigatus; uncharacterized protein 1577770 4982979 An08g06620 Aspergillus niger uncharacterized protein XP_001392777.1 1577287 D 5061 CDS An08g06630 4982980 join(1579034..1579081,1579147..1579887) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein CAF32079.1 - Aspergillus fumigatus; uncharacterized protein 1579887 4982980 An08g06630 Aspergillus niger uncharacterized protein XP_059604111.1 1579034 D 5061 CDS An08g06640 84591716 join(1581335..1581382,1581417..1581437,1581468..1581644) VIII 1 NT_166524.1 hypothetical protein 1581644 84591716 An08g06640 Aspergillus niger hypothetical protein XP_059604112.1 1581335 D 5061 CDS An08g06650 4982982 complement(join(1582424..1582721,1582749..1582806,1582997..1583315)) VIII 1 NT_166524.1 Complex: NHP2 of S. cerevisiae is a component of the box H/ACA small nucleolar ribonucleoprotein particles (H/ACA snoRNPs), involved in pseudouridylation of pre-rRNAs, playing a key role in the synthesis of eukaryotic ribosomes.; Function: NHP2 of S. cerevisiae is directly interacting with RNA, facilitating the assembly of H/ACA snoRNPs, their retention into the nucleolus, and hence their function.; Similarity: NHP2 of S. cerevisiae and the predicted protein show strong similarity to ribosomal protein L7a.; Similarity: the N-terminal part of the predicted protein shows no similarity to S. cerevisiae NHP2.; Title: strong similarity to nucleolar rRNA processing protein Nhp2 - Saccharomyces cerevisiae; nucleus; See PMID 2063628; See PMID 9843512; See PMID 10502409; See PMID 10690410; See PMID 11074001; uncharacterized protein 1583315 4982982 An08g06650 Aspergillus niger uncharacterized protein XP_059604113.1 1582424 R 5061 CDS An08g06660 4982983 join(1583817..1583901,1583961..1584112,1584176..1586098) VIII 1 NT_166524.1 Complex: MAD1 of S. cerevisiae forms a tight complex with another spindle checkpoint protein, MAD2, throughout the cell cycle; furthermore, MAD1 interacts with CDC20,which activates the anaphase promoting complex, in the two-hybrid system, and the presence of MAD1 is required for MAD2 and MAD3 to interact with CDC20.; Function: MAD1 of S. cerevisiae is a non-essential gene that encodes a component of the spindle checkpoint,which delays the onset of anaphase in cells with defects in mitotic spindle assembly or in the attachment of chromosomes to the spindle microtubules.; Regulation: MAD1 of S. cerevisiae becomes hyperphosphorylated upon spindle depolymerization, and the essential protein kinase MSP1 appears to phosphorylate MAD1.; Title: strong similarity to spindle assembly checkpoint protein Mad1 - Saccharomyces cerevisiae; nucleus; See PMID 7593191; See PMID 7880536; See PMID 8524250; See PMID 8895658; See PMID 1651172; uncharacterized protein 1586098 4982983 An08g06660 Aspergillus niger uncharacterized protein XP_001392781.3 1583817 D 5061 CDS An08g06670 4982984 complement(join(1587144..1588301,1588358..1588463,1588518..1588597,1588651..1589045,1589131..1589765,1589833..1589918,1589996..1590088,1590205..1590240)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein SPBC4C3.06 - Schizosaccharomyces pombe; uncharacterized protein 1590240 4982984 An08g06670 Aspergillus niger uncharacterized protein XP_001392782.1 1587144 R 5061 CDS An08g06680 4982985 join(1591011..1591022,1591151..1591834,1591905..1592060,1592362..1592436) VIII 1 NT_166524.1 Function: Cdk2 of R. norvegicus interacts with cyclins A, D, or E; the activity of Cdk2 is maximal during S phase and G2.; Function: Cyclin-dependent kinase 2 (Cdk2) controls the transition from the G1 to the S phase in the mammalian cell cycle.; Title: strong similarity to cyclin dependent kinase 2-alpha Cdk2-alpha - Rattus norvegicus; deleted EC_number 2.7.1.37; See PMID 7862443; uncharacterized protein 1592436 4982985 An08g06680 Aspergillus niger uncharacterized protein XP_059604114.1 1591011 D 5061 CDS An08g06690 4982986 1594289..1596571 VIII 1 NT_166524.1 Similarity: more than 50% of the predicted protein length is constituted by low-complexity regions, explaining all the found BLASTP alignments, that cannot be considered functionally relevant.; Title: strong similarity to hypothetical protein CAD29595.1 - Aspergillus fumigatus; uncharacterized protein 1596571 4982986 An08g06690 Aspergillus niger uncharacterized protein XP_059604115.1 1594289 D 5061 CDS An08g06700 4982987 complement(join(1597419..1597532,1597677..1599896)) VIII 1 NT_166524.1 Function: ys1 of Z. mays is a membrane protein involved in iron uptake, mediating the import of the (Fe3+)-phytosiderophore complex at the root surface.; Similarity: the predicted protein shows much stronger similarity to a N. crassa and a S. cerevisiae hypothetical proteins.; Title: strong similarity to iron-phytosiderophore transporter protein yellow stripe 1 ys1 - Zea mays [putative frameshift]; plasma membrane; putative frameshift; See PMID 11201743; uncharacterized protein 1599896 4982987 An08g06700 Aspergillus niger uncharacterized protein XP_059604116.1 1597419 R 5061 CDS An08g06710 4982988 complement(join(1600306..1600763,1600885..1601404)) VIII 1 NT_166524.1 Catalytic activity: (R)-glycerate + NAD(+) = hydroxypyruvate + NADH.; Complex: HPRA of M. extorquens is a homodimer.; Function: HPRA of M. extorquens plays a central role in assimilation of carbon; it converts hydroxypyruvate to glycerate as a key step in the serine cycle, and may also play an important role in C2 reactions, by interconverting glyoxylate and glycolate.; Pathway: serine pathway.; Title: strong similarity to hydroxypyruvate dehydrogenase HPRA - Methylobacterium extorquens; See PMID 8144463; See PMID 1657886; See PMID 1729225; uncharacterized protein 1601404 4982988 An08g06710 Aspergillus niger uncharacterized protein XP_059604117.1 1600306 R 5061 CDS An08g06720 4982989 complement(join(1601761..1602732,1602797..1603026,1603078..1603112,1603165..1603622,1603676..1603889,1604028..1604053)) VIII 1 NT_166524.1 Catalytic activity: phenol + NADPH + O(2) = catechol + NADP(+) + H(2)O (acts also on monohydroxy-, monohalo-,monoamino- and monomethylphenols).; Complex: phenol hydroxilase of T. cutaneum is a homodimer.; Pathway: phenol hydroxilase, also called phenol 2-monooxygenase, catalyzes the first step of phenol biodegradation.; Title: strong similarity to phenol hydroxylase -Trichosporon cutaneum; See PMID 2298204; See PMID 1429434; uncharacterized protein 1604053 4982989 An08g06720 Aspergillus niger uncharacterized protein XP_059604118.1 1601761 R 5061 CDS An08g06730 4982990 join(1605377..1605391,1605440..1605963,1606096..1606315) VIII 1 NT_166524.1 Title: weak similarity to hypothetical protein CAD29600.1 - Aspergillus fumigatus; uncharacterized protein 1606315 4982990 An08g06730 Aspergillus niger uncharacterized protein XP_001392788.3 1605377 D 5061 CDS An08g06740 4982991 1606731..1607630 VIII 1 NT_166524.1 Similarity: the BLASTP hits are due to the high content of low-complexity regions.; Title: weak similarity to hypothetical 1,4-beta-cellobiosidase XF1267 - Xylella fastidiosa; uncharacterized protein 1607630 4982991 An08g06740 Aspergillus niger uncharacterized protein XP_001392789.1 1606731 D 5061 CDS An08g06750 4982992 complement(join(1607859..1608359,1608409..1608659,1608707..1608953,1609004..1609459,1609495..1611198,1611244..1611765,1611835..1612023,1612116..1612196)) VIII 1 NT_166524.1 Complex: RAV1 of S. cerevisiae, with RAV2 and SKP1 form a complex called RAVE, regulator of the (H+)-ATPase of the vacuolar and endosomal membranes (V-ATPase).; Function: the RAVE complex promotes the glucose-triggered assembly of the V-ATPase holoenzyme.; Remark: RAV1 of S. cerevisiae is also called YJR033c.; Remark: V-ATPases are conserved throughout eukaryotes, and have been implicated in tumour metastasis and multidrug resistance.; Title: strong similarity to regulator protein Rav1 -Saccharomyces cerevisiae; See PMID 11283612; uncharacterized protein 1612196 4982992 An08g06750 Aspergillus niger uncharacterized protein XP_059604119.1 1607859 R 5061 CDS An08g06760 4982993 complement(join(1613684..1616931,1617026..1617089)) VIII 1 NT_166524.1 Remark: SFI1 of S. cerevisiae is an essential gene and is required for cell cycle progression, more specifically for progression through G(2)-M transition. the protein might be required for correct mitotic spindle assembly and its precise role might be in chromosome condensation.; Remark: Sfi1 may be a downstream target of the protein kinase A pathway.; Title: similarity to suppressor of fil1 Sfi1 -Saccharomyces cerevisiae; See PMID 10455233; uncharacterized protein 1617089 4982993 An08g06760 Aspergillus niger uncharacterized protein XP_001392791.1 1613684 R 5061 CDS An08g06770 4982994 complement(join(1618084..1620888,1620949..1621377)) VIII 1 NT_166524.1 Catalytic activity: ATP + L-isoleucine + tRNA(Ile) = AMP + pyrophosphate + L-isoleucyl-tRNA(Ile).; Pathway: valine, leucine and isoleucine biosynthesis; aminoacyl-tRNA biosynthesis.; Remark: also strong similarity to isoleucyl-tRNA synthetase protein sequence from Candida albicans patent US5885815-A.; Remark: isoleucyl-tRNA synthetase ILS1 of S. cerevisiae is essential.; Similarity: belongs to the class I aminoacyl-tRNA synthetase family.; Title: strong similarity to cytoplasmic isoleucine--tRNA ligase Ils1 - Saccharomyces cerevisiae; cytoplasm; See PMID 2663194; See PMID 3311074; See PMID 10466139; uncharacterized protein 1621377 4982994 An08g06770 Aspergillus niger uncharacterized protein XP_001392792.1 1618084 R 5061 CDS An08g06780 4982995 complement(join(1621851..1621943,1622001..1624397,1624443..1624906,1624995..1625199,1625241..1625291,1625348..1625623)) VIII 1 NT_166524.1 Domain: the rodlike tail sequence is highly repetitive, composed of an heptapeptide repeat pattern characteristic of alpha-helical coiled coils. may form filamentous structures in the cell.; Function: required for protein transport from the ER to the golgi complex.; Localization: cytoplasmic. associated with intracellular membranes. probably present on vesicles operational between the ER and the golgi complex.; Remark: best blastP match to unknown gene B13I18. 10 of Neurospora crassa, which is related to transport protein USO1.; Similarity: belongs to the p115(tap)/uso1/ybl047c family.; Title: strong similarity to transport protein Uso1 -Saccharomyces cerevisiae; cytoplasm; See PMID 2010462; See PMID 8603910; uncharacterized protein 1625623 4982995 An08g06780 Aspergillus niger uncharacterized protein XP_059604120.1 1621851 R 5061 CDS An08g06790 4982996 join(1626350..1626656,1626732..1627009,1627061..1628985,1629064..1629691) VIII 1 NT_166524.1 Function: genetic experiments showed that dhp1+ of S. pombe on an S. cerevisiae expression vector could rescue both the defects of the S. cerevisiae DST2 disruptant,slow growth rate and a sporulation defect, and the lethality of the S. cerevisiae rat1ts mutation. This implies the functional similarity of dhp1+ to both DST2 and RAT1.; Remark: RAT1/HKE1 of S. cerevisiae is involved in RNA trafficking and processing.; Remark: STP beta of S. cerevisiae is required for homologous recombination in both mitotic or meiotic cells.; Remark: dhp1+ of S. pombe is an essential gene for cell growth in S. pombe, suggesting that dhp1+ is not the true homologue of DST2 but rather of RAT1 in S. pombe.; Similarity: strong similarity to STP beta (encoded by the DST2 gene) of S. cerevisiae and RAT1/HKE1 of S. cerevisiae.; Title: strong similarity to DNA exoribonuclease dhp1p - Schizosaccharomyces pombe; uncharacterized protein 1629691 4982996 An08g06790 Aspergillus niger uncharacterized protein XP_001392794.1 1626350 D 5061 CDS An08g06800 84591717 1630976..>1631926 VIII 1 NT_166524.1 Remark: C-terminal truncated ORF due to end of contig.; Remark: a splice site was detected upstream of the START codon.; Remark: the AROM locus of Aspergillus nidulans specifies a pentafunctional polypeptide catalysing five consecutive steps leading to the production of 5-enolpyruvylshikimate 3-phosphate in the shikimate pathway. the whole AROM locus and various overlapping subfragments from within it have been expressed in appropriate aro mutants of E. coli to delineate functional domains within the arom polypeptide. the arom polypeptide falls in two independently folding and functioning regions,the N-terminal half specifying 3-dehydroquinate (DHQ) synthase and EPSP synthase and the C-terminus specifying shikimate kinase, biosynthetic 3-dehydroquinase (DHQase) and shikimate dehydrogenase.; Title: strong similarity to penta-functional enzyme aROM - Aspergillus nidulans [truncated ORF]; See PMID 2836080; See PMID 1849480; uncharacterized protein 1631926 84591717 An08g06800 Aspergillus niger uncharacterized protein XP_059604121.1 1630976 D 5061 CDS An08g06810 4982998 join(<1632028..1635040,1635099..1635143,1635210..>1635248) VIII 1 NT_166524.1 Catalytic activity: the AROM protein in A. nidulans contains five separate enzymatic domains (3-dehydroquinate synthase, 3-dehydroquinate dehydratase, shikimate 5-dehydrogenase, shikimate kinase, EPSP synthase).; Pathway: the AROM protein in A. nidulans catalyses five consecutive enzymatic steps leading to the production of 5-enolpyruvylshikimate 3-phosphate (EPSP) in the shikimate pathway.; Remark: a putative sequencing error results in an frameshift.; Remark: the ORF is N-terminally truncated due to end of contig.; Title: strong similarity to pentafunctional enzyme aroM - Aspergillus nidulans [truncated ORF] [putative frameshift]; cytoplasm; putative frameshift; See PMID 8383607; See PMID 8393515; uncharacterized protein 1635248 4982998 An08g06810 Aspergillus niger uncharacterized protein XP_001392796.3 1632028 D 5061 CDS An08g06820 84591718 join(1635760..1635792,1635822..1635825,1635867..1635894,1636203..1636207,1636295..1636308,1636426..1636455) VIII 1 NT_166524.1 Title: questionable ORF; uncharacterized protein 1636455 84591718 An08g06820 Aspergillus niger uncharacterized protein XP_059604122.1 1635760 D 5061 CDS An08g06830 84591719 complement(join(1636766..1636821,1637000..1637015,1637257..1637298)) VIII 1 NT_166524.1 Title: questionable ORF; uncharacterized protein 1637298 84591719 An08g06830 Aspergillus niger uncharacterized protein XP_059604123.1 1636766 R 5061 CDS An08g06840 84591720 complement(join(1638041..1638253,1638439..1638607,1638686..1638775,1638858..1638925)) VIII 1 NT_166524.1 hypothetical protein 1638925 84591720 An08g06840 Aspergillus niger hypothetical protein XP_059604124.1 1638041 R 5061 CDS An08g06850 4983002 join(1642174..1643047,1643114..1644345) VIII 1 NT_166524.1 Function: hypothetical C2H2 zinc-finger protein,contains 3 putative C2H2 motives (Pfam); Similarity: C-terminus also shows similarity to 26S proteasome regulatory particle chain RPN4 (nuclear protein SON1, Ub fusion degradation protein 5) of S. cerevisiae.; Similarity: only C-terminus shows similarity to hypothetical C2H2 zinc-finger protein of S. pombe.; Title: similarity to hypothetical C2H2 zinc-finger protein SPBC1105.14 - Schizosaccharomyces pombe; uncharacterized protein 1644345 4983002 An08g06850 Aspergillus niger uncharacterized protein XP_001392800.1 1642174 D 5061 CDS An08g06860 84591721 complement(join(1645258..1645400,1645434..1645537,1645637..1645659)) VIII 1 NT_166524.1 hypothetical protein 1645659 84591721 An08g06860 Aspergillus niger hypothetical protein XP_059604125.1 1645258 R 5061 CDS An08g06870 84591722 complement(join(1646768..1646917,1647097..1647225,1647287..1647484)) VIII 1 NT_166524.1 hypothetical protein 1647484 84591722 An08g06870 Aspergillus niger hypothetical protein XP_059604126.1 1646768 R 5061 CDS An08g06880 84591723 complement(join(1647584..1647786,1647979..1648124,1648176..1648280,1648316..1648506,1648595..1648800,1648885..1649056)) VIII 1 NT_166524.1 Similarity: N-terminal part shows weak similarity to S-adenosylmethionine decarboxylases of diverse plant species.; hypothetical protein 1649056 84591723 An08g06880 Aspergillus niger hypothetical protein XP_059604127.1 1647584 R 5061 CDS An08g06890 4983006 complement(1650307..1651191) VIII 1 NT_166524.1 Remark: ubiG of E. coli is also known as 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase.; Similarity: shows weak similarity to several bacterial and eukaryotic methyltransferases of different specificities.; Similarity: the similarity covers only the central part of the protein, C- and N-terminus shows no similarity.; Title: weak similarity to 3-demethylubiquinone-9 3-O-methyltransferase ubiG - Escherichia coli; uncharacterized protein 1651191 4983006 An08g06890 Aspergillus niger uncharacterized protein XP_001392804.1 1650307 R 5061 CDS An08g06900 84591724 join(1651565..1651812,1651895..1651943,1652151..1652428,1652486..1652561) VIII 1 NT_166524.1 hypothetical protein 1652561 84591724 An08g06900 Aspergillus niger hypothetical protein XP_059604128.1 1651565 D 5061 CDS An08g06910 84591725 complement(join(1652733..1652822,1652965..1653084,1653199..1653255,1653356..1653522,1653561..1653667,1653755..1653777,1653909..1654045,1654133..1654183,1654277..1654346)) VIII 1 NT_166524.1 hypothetical protein 1654346 84591725 An08g06910 Aspergillus niger hypothetical protein XP_059604129.1 1652733 R 5061 CDS An08g06920 84591726 complement(join(1655108..1655524,1655611..1655692,1655774..1655848,1655940..1656051,1656113..1656119)) VIII 1 NT_166524.1 hypothetical protein 1656119 84591726 An08g06920 Aspergillus niger hypothetical protein XP_059604130.1 1655108 R 5061 CDS An08g06930 84591727 complement(join(1656984..1657184,1657246..1657287,1657322..1657423)) VIII 1 NT_166524.1 hypothetical protein 1657423 84591727 An08g06930 Aspergillus niger hypothetical protein XP_059604131.1 1656984 R 5061 CDS An08g06940 4983011 complement(join(1657841..1657866,1657926..1658201,1658305..1658314)) VIII 1 NT_166524.1 Function: histone H4 forms part of the octameric (2*H2A, 2*H2B, 2*H3, 2*H4) nucleosome core.; Title: strong similarity to histone H4.1 -Aspergillus nidulans; nucleus; See PMID 2274040; uncharacterized protein 1658314 4983011 An08g06940 Aspergillus niger uncharacterized protein XP_001392809.1 1657841 R 5061 CDS An08g06950 84591728 complement(join(1658640..1658936,1659002..1659043)) VIII 1 NT_166524.1 hypothetical protein 1659043 84591728 An08g06950 Aspergillus niger hypothetical protein XP_059604132.1 1658640 R 5061 CDS An08g06960 4983013 join(1659143..1659167,1659277..1659384,1659454..1659731) VIII 1 NT_166524.1 Function: histone H3 forms part of the octameric (2*H2A, 2*H2B, 2*H3, 2*H4) nucleosome core.; Function: histone H3 lysin 9 methylation by Clr4 in S. pombe is necessary for Swi6 mediated gene silencing.; Similarity: deduced aa sequence is identical to histone H3 of E. nidulans.; Title: strong similarity to histone H3 - Aspergillus nidulans; nucleus; See PMID 2274040; See PMID 11242054; uncharacterized protein 1659731 4983013 An08g06960 Aspergillus niger uncharacterized protein XP_001392811.1 1659143 D 5061 CDS An08g06970 84591729 complement(join(1663735..1663846,1663945..1664142,1664322..1664390,1664439..1664533,1664593..1664693,1664807..1664918,1665009..1665017)) VIII 1 NT_166524.1 hypothetical protein 1665017 84591729 An08g06970 Aspergillus niger hypothetical protein XP_059604133.1 1663735 R 5061 CDS An08g06980 4983015 join(1665076..1665448,1665504..1665758,1665819..1666999) VIII 1 NT_166524.1 Function: FLU1 of C. albicans facilitates resistance to fluconazole and cycloheximide in the fluconazole-hypersensitive S. cerevisiae strain YKKB-13 lacking the ABC (ATP-binding cassette) transporter gene PDR5.; Function: FLU1 of C. albicans facilitates resistance to mycophenolic acid in C. albicans; Function: FLU1 of C. albicans is involved in the resistance to azol derivatives in C. albicans; Function: MDR1 of C. albicans facilitates resistance to the anti-mitotic drug benomyl and to the dihydrofolate reductase inhibitor methotrexate.; Similarity: FLU1 and MDR1 of C. albicans are members of the major falicitator superfamily; Similarity: N-terminus is ca. 90 aa shorter and C-terminus ca. 90 aa longer than in FLU1 of C. albicans; Similarity: similar to the MDR1 (formerly BEN(r)/BMR) protein of C. albicans; Similarity: strong similarity (including the very C-terminus) to hypothetical mdr protein of Penicillium olsonii; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; plasma membrane; See PMID 11065353; uncharacterized protein 1666999 4983015 An08g06980 Aspergillus niger uncharacterized protein XP_001392813.1 1665076 D 5061 CDS An08g06990 4983016 join(1667908..1668434,1668499..1668913) VIII 1 NT_166524.1 Title: similarity to hypothetical membrane protein YLR251w - Saccharomyces cerevisiae; uncharacterized protein 1668913 4983016 An08g06990 Aspergillus niger uncharacterized protein XP_001392814.1 1667908 D 5061 CDS An08g07000 84591730 1669308..1669748 VIII 1 NT_166524.1 Title: similarity to hypothetical protein CAF32094.1/AfA19D12.030 - Aspergillus fumigatus; uncharacterized protein 1669748 84591730 An08g07000 Aspergillus niger uncharacterized protein XP_059604134.1 1669308 D 5061 CDS An08g07010 4983018 complement(join(1670422..1671187,1671259..1671382,1671445..1671497,1671554..1671656,1671715..1671910)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein mlr7324 -Mesorhizobium loti; uncharacterized protein 1671910 4983018 An08g07010 Aspergillus niger uncharacterized protein XP_001392816.1 1670422 R 5061 CDS An08g07020 4983019 complement(join(1672387..1672650,1672705..1673499,1673552..1674224,1674290..1674366)) VIII 1 NT_166524.1 Phenotype: deletion of the ALG9 gene leads to accumulation of lipid-linked Man6GlcNAc2 in vivo and to hypoglycosylation of secreted proteins.; Remark: protein N1295; protein YNL219c are alternative names for Alg9; Title: similarity to mannosyl transferase Alg9 -Saccharomyces cerevisiae; See PMID 8692962; uncharacterized protein 1674366 4983019 An08g07020 Aspergillus niger uncharacterized protein XP_001392817.1 1672387 R 5061 CDS An08g07030 4983020 1674643..1676646 VIII 1 NT_166524.1 Title: similarity to hypothetical protein YNL124w -Saccharomyces cerevisiae; uncharacterized protein 1676646 4983020 An08g07030 Aspergillus niger uncharacterized protein XP_001392818.1 1674643 D 5061 CDS An08g07040 4983021 complement(1677050..1678675) VIII 1 NT_166524.1 Function: PRP3 of S. cerevisiae is required for assembly of spliceosomes from prespliceosomes.; Phenotype: S. cerevisisae prp3-1 mutant exhibits altered assembly or stability of U4/U6 snRNP.; Remark: RNA3 is an alternative name for PRP3.; Title: similarity to splicing factor Prp3 -Saccharomyces cerevisiae; nucleus; See PMID 9326489; See PMID 9826507; uncharacterized protein 1678675 4983021 An08g07040 Aspergillus niger uncharacterized protein XP_001392819.3 1677050 R 5061 CDS An08g07050 4983022 join(1679180..1679364,1679445..1679936,1680001..1682779,1682839..1684425) VIII 1 NT_166524.1 Function: active RNA polymerase I is required for the formation of the chromosome nucleolus.; Remark: RPA190 of S. pombe is also called nuc1,SPRPA190 or SPBC4c3. 05c.; Title: strong similarity to 189 kD subunit of DNA-directed RNA polymerase I rpa190p - Schizosaccharomyces pombe; nucleus; See PMID 2854522; uncharacterized protein 1684425 4983022 An08g07050 Aspergillus niger uncharacterized protein XP_001392820.1 1679180 D 5061 CDS An08g07060 4983023 complement(join(1684894..1686708,1686766..1686882,1686932..1687388,1687460..1687476)) VIII 1 NT_166524.1 Phenotype: S. pombe rad15 gene is essential for viability, suggesting that the protein product has a role in cell proliferation and not solely in DNA repair.; Phenotype: the S. pombe rad15. P mutant is highly sensitive to UV radiation, but only slightly sensitive to ionising radiation, as expected for a mutant defective in excision repair.; Remark: RHP3 or SPAC1D4 are alternative names for RAD15 in S. pombe.; Title: strong similarity to subunit of transcription initation factor TFIIH DNA repair helicase rad15p -Schizosaccharomyces pombe; nucleus; See PMID 1319571; See PMID 1534406; uncharacterized protein 1687476 4983023 An08g07060 Aspergillus niger uncharacterized protein XP_001392821.1 1684894 R 5061 CDS An08g07070 4983024 join(1687874..1688173,1688209..1688632,1688686..1690414,1690461..1691305,1691357..1691773,1691821..1692194,1692243..1692542,1692594..1693115) VIII 1 NT_166524.1 Function: the protein from patent WO9964455-A1 is involved in nuclear transport.; Title: similarity to nuclear transport protein clone hfb341 from patent WO9964455-A1 - Homo sapiens; nucleus; uncharacterized protein 1693115 4983024 An08g07070 Aspergillus niger uncharacterized protein XP_059601195.1 1687874 D 5061 CDS An08g07080 4983025 join(1693510..1693771,1693840..1694684) VIII 1 NT_166524.1 Function: No direct effects on phosphatase activity changes were observed upon methylation of the dimeric or trimeric forms of PP2A.; Function: human LCMT methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2a catalytic subunits (PP2CA) to form alpha-leucine ester residues.; Similarity: human LCMT is distinct from other known protein methyltransferases, sharing only sequence motifs supposedly involved in the binding of adenosylmethionine; Title: strong similarity to leucine carboxyl methyltransferase LCMT - Homo sapiens; See PMID 10600115; uncharacterized protein 1694684 4983025 An08g07080 Aspergillus niger uncharacterized protein XP_001392823.1 1693510 D 5061 CDS An08g07090 4983026 join(1696036..1696350,1696400..1696632,1696667..1697657) VIII 1 NT_166524.1 Phenotype: Sim1 disruption allows clb1 clb2 clb3 clb4 quadruple null mutants to perform DNA re-replication before blocking in G2.; Phenotype: Sim1 mutants have a longer lifespan and better viability upon starvation.; Title: similarity to protein Sim1 - Saccharomyces cerevisiae; See PMID 8574583; uncharacterized protein 1697657 4983026 An08g07090 Aspergillus niger uncharacterized protein XP_059601196.1 1696036 D 5061 CDS An08g07100 4983027 1698546..1699505 VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein CAF32105.1 - Aspergillus fumigatus; uncharacterized protein 1699505 4983027 An08g07100 Aspergillus niger uncharacterized protein XP_001392825.3 1698546 D 5061 CDS An08g07110 4983028 complement(join(1699820..1700776,1700828..1701009,1701057..1702084,1702374..1702384,1702719..1702990,1703165..1703189)) VIII 1 NT_166524.1 Similarity: the ORF encoded protein also shows weak similarity to tetracycline transporters of several species as well as two PFAM transporter motifs.; Title: similarity to hypothetical transport protein YCR023c - Saccharomyces cerevisiae; uncharacterized protein 1703189 4983028 An08g07110 Aspergillus niger uncharacterized protein XP_001392826.3 1699820 R 5061 CDS An08g07120 4983029 complement(join(1703449..1705287,1705318..1705524,1705578..1705700)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein BAC67939.1 - Streptomyces avermitilis; uncharacterized protein 1705700 4983029 An08g07120 Aspergillus niger uncharacterized protein XP_059601197.1 1703449 R 5061 CDS An08g07130 84591731 join(1705784..1705922,1706131..1706498) VIII 1 NT_166524.1 hypothetical protein 1706498 84591731 An08g07130 Aspergillus niger hypothetical protein XP_059601198.1 1705784 D 5061 CDS An08g07140 84591732 1708420..1708770 VIII 1 NT_166524.1 hypothetical protein 1708770 84591732 An08g07140 Aspergillus niger hypothetical protein XP_059601199.1 1708420 D 5061 CDS An08g07150 4983032 complement(join(1709118..1709553,1709610..1709713,1709768..1709940,1709999..1710143)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein mlr2056 -Mesorhizobium loti; uncharacterized protein 1710143 4983032 An08g07150 Aspergillus niger uncharacterized protein XP_001392830.1 1709118 R 5061 CDS An08g07160 84591733 join(1710608..1710767,1710885..1710971,1711143..1711522) VIII 1 NT_166524.1 hypothetical protein 1711522 84591733 An08g07160 Aspergillus niger hypothetical protein XP_059601200.1 1710608 D 5061 CDS An08g07170 84591734 join(1711721..1711886,1712229..1712326,1712583..1712972) VIII 1 NT_166524.1 hypothetical protein 1712972 84591734 An08g07170 Aspergillus niger hypothetical protein XP_059601201.1 1711721 D 5061 CDS An08g07180 84591735 complement(join(1713227..1713330,1713423..1713476,1713565..1713729,1713848..1713977)) VIII 1 NT_166524.1 hypothetical protein 1713977 84591735 An08g07180 Aspergillus niger hypothetical protein XP_059601202.1 1713227 R 5061 CDS An08g07190 84591736 join(1714044..1714171,1714263..1714266,1714343..1714408,1714457..1714627) VIII 1 NT_166524.1 hypothetical protein 1714627 84591736 An08g07190 Aspergillus niger hypothetical protein XP_059601203.1 1714044 D 5061 CDS An08g07200 4983037 complement(join(1715232..1715333,1715426..1715656,1715738..1715767,1715828..1715867,1715941..1715975)) VIII 1 NT_166524.1 Complex: the subunit composition of the plasma membrane adaptor complex is alpha-adaptin, beta-adaptin,AP50, and AP17.; Function: AP17 is a component of the clathrin-associated protein complexes found in coated structures of the plasma membrane and is believed to interact with cytoplasmic domains of receptors found in the plasma membrane.; Title: strong similarity to clathrin-associated protein 17 - Rattus norvegicus; plasma membrane; See PMID 7593184; See PMID 2040623; See PMID 2495531; uncharacterized protein 1715975 4983037 An08g07200 Aspergillus niger uncharacterized protein XP_001392835.1 1715232 R 5061 CDS An08g07210 4983038 join(1716744..1717325,1717390..1717440) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein CAF32111.1 - Aspergillus fumigatus; uncharacterized protein 1717440 4983038 An08g07210 Aspergillus niger uncharacterized protein XP_001392836.1 1716744 D 5061 CDS An08g07220 4983039 complement(join(1717637..1718234,1718297..1718421,1718502..1718636)) VIII 1 NT_166524.1 Function: DPH5 of S. cerevisiae converts S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine to S-adenosyl-L-homocysteine + 2-[3-carboxy-3-(methylammonio)propyl]-L-histidine.; Pathway: Diphthamide, a unique amino acid, is a post-translational derivative of histidine that exists in protein synthesis elongation factor 2 at the site of diphtheria toxin-catalyzed ADP-ribosylation of elongation factor 2.; Remark: YLR172c ist the systematic name for DPH5 of S. cerevisiae.; Title: strong similarity to diphthamide methyltransferase Dph5 - Saccharomyces cerevisiae; See PMID 6717439; See PMID 1508200; uncharacterized protein 1718636 4983039 An08g07220 Aspergillus niger uncharacterized protein XP_001392837.1 1717637 R 5061 CDS An08g07230 4983040 join(1719560..1719706,1719752..1720585,1720637..1720642) VIII 1 NT_166524.1 Complex: SPT3 from S. cerevisiae is part of the SAGA complex.; Function: SPT3 from S. cerevisiae is required for the initiation of TY transcription from the delta promoter.; Remark: BLU1 and YDR392w are alternative names for SPT3.; Title: strong similarity to regulator protein Spt3 -Saccharomyces cerevisiae; nucleus; See PMID 3020500; uncharacterized protein 1720642 4983040 An08g07230 Aspergillus niger uncharacterized protein XP_001392838.3 1719560 D 5061 CDS An08g07240 4983041 complement(join(1721156..1721178,1721244..1721652,1721758..1721958)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical blue-light-inducible protein bli-3 - Neurospora crassa; uncharacterized protein 1721958 4983041 An08g07240 Aspergillus niger uncharacterized protein XP_001392839.1 1721156 R 5061 CDS An08g07250 4983042 complement(join(1722326..1722521,1722636..1725280)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein EAA58154.1 - Aspergillus nidulans; uncharacterized protein 1725280 4983042 An08g07250 Aspergillus niger uncharacterized protein XP_059601204.1 1722326 R 5061 CDS An08g07260 84591737 complement(join(1726021..1726471,1726706..1726906,1727118..1727197,1727281..1727360,1727415..1727418)) VIII 1 NT_166524.1 hypothetical protein 1727418 84591737 An08g07260 Aspergillus niger hypothetical protein XP_059601205.1 1726021 R 5061 CDS An08g07270 4983044 complement(join(1727644..1728160,1728252..1728994)) VIII 1 NT_166524.1 Function: F. sporotrichioides TRI7 (FsTRI7) is required for acetylation of the oxygen on C-4 of T-2 toxin.; Pathway: TRI7 of F. sporotrichioides contributes in the trichothecene T2-toxin synthesis.; Remark: trichothecenes are sesquiterpenoid mycotoxins and act as protein synthesis inhibitors for eukaryotic organisms.; Title: strong similarity to T-2 toxin biosynthesis protein TRI7 - Fusarium sporotrichioides; See PMID 11352533; uncharacterized protein 1728994 4983044 An08g07270 Aspergillus niger uncharacterized protein XP_001392842.3 1727644 R 5061 CDS An08g07280 4983045 join(1730201..1730299,1730353..1731131,1731189..1731322,1731393..1731625) VIII 1 NT_166524.1 Function: S. aureus hmrA conferred Eagle-type resistance, i. e. resistance to high concentrations of methicillin (64 to 512 microg/ml) and susceptibility to low concentrations of methicillin (2 to 16 microg/ml), when introduced into the cell in multiple copies.; Similarity: the predicted A. niger protein shows similarity to several putative hydrolase proteins and contains a hydrolase BLOCKs motif.; Title: strong similarity to methicillin resistance gene HmrA - Staphylococcus aureus; See PMID 11181367; uncharacterized protein 1731625 4983045 An08g07280 Aspergillus niger uncharacterized protein XP_001392843.3 1730201 D 5061 CDS An08g07290 4983046 complement(join(1732419..1732575,1732629..1732698,1732756..1733957,1734027..1734091)) VIII 1 NT_166524.1 Catalytic activity: aldehyde + NAD+ + H2O = acid + NADH.; Gene-ID: aldA; Pathway: aldehyde dehydrogenase of A. niger catalyzes the second step in ethanol utilization.; Similarity: aldehyde dehydrogenase of A. niger belongs to the aldehyde dehydrogenases family.; See PMID 1644309; aldehyde dehydrogenase aldA-Aspergillus niger 1734091 aldA 4983046 aldA Aspergillus niger aldehyde dehydrogenase aldA-Aspergillus niger XP_001392844.1 1732419 R 5061 CDS An08g07300 84591738 join(1735526..1735689,1735826..1735930,1736068..1736170) VIII 1 NT_166524.1 hypothetical protein 1736170 84591738 An08g07300 Aspergillus niger hypothetical protein XP_059601206.1 1735526 D 5061 CDS An08g07310 4983048 join(1736408..1736800,1736898..1737242) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein all4736 - Nostoc sp.; uncharacterized protein 1737242 4983048 An08g07310 Aspergillus niger uncharacterized protein XP_001392846.1 1736408 D 5061 CDS An08g07320 4983049 join(1737739..1737766,1737827..1738176,1738226..1739728) VIII 1 NT_166524.1 Title: strong similarity to hypothetical conserved protein SCD10.11 - Streptomyces coelicolor; uncharacterized protein 1739728 4983049 An08g07320 Aspergillus niger uncharacterized protein XP_001392847.1 1737739 D 5061 CDS An08g07330 4983050 complement(join(1740114..1740284,1740320..1742367,1742418..1742433)) VIII 1 NT_166524.1 Phenotype: the rad32 mutant undergoes decreased meiotic recombination and displays reduced stability of minichromosomes.; Phenotype: the rad32 mutant, in comparison to wild type cells, has decreased ability to repair DNA double strand breaks.; Similarity: rad32 of S. pombe shows similarity to the meiotic recombination gene MRE11 of S. cerevisiae.; Title: strong similarity to DNA repair phosphoesterase rad32p - Schizosaccharomyces pombe; nucleus; See PMID 7885834; uncharacterized protein 1742433 4983050 An08g07330 Aspergillus niger uncharacterized protein XP_059601207.1 1740114 R 5061 CDS An08g07340 4983051 1743546..1746524 VIII 1 NT_166524.1 Title: weak similarity to hypothetical F-box domain protein - Schizosaccharomyces pombe; uncharacterized protein 1746524 4983051 An08g07340 Aspergillus niger uncharacterized protein XP_001392849.3 1743546 D 5061 CDS An08g07350 4983052 complement(join(1747393..1748328,1748390..1748674,1748741..1748840,1748921..1749051,1749117..1749125)) VIII 1 NT_166524.1 Phenotype: gas1 muntants show altered cell wall glucan levels, they are reduced in beta1,3-glucan.; Phenotype: gas1delta cells release beta1,3-glucan into the medium indicating that Gas1p is indeed involved in the incorporation of 1,3-glucan in the cell wall.; Remark: GGP1, GP115 CWH52 and YMR307w are alternative names for Gas1 in S. cerevisisae.; Title: strong similarity to precursor of glycophospholipid-anchored surface glycoprotein Gas1 -Saccharomyces cerevisiae; plasma membrane; See PMID 9515908; uncharacterized protein 1749125 4983052 An08g07350 Aspergillus niger uncharacterized protein XP_001392850.1 1747393 R 5061 CDS An08g07360 4983053 complement(join(1750428..1750627,1750713..1750958,1751048..1751105)) VIII 1 NT_166524.1 Complex: forms part of the receptor complex that consists of at least 8 different proteins (TOM5, TOM6, TOM7, TOM20, TOM22, TOM37, TOM40 and TOM70).; Function: TOM20 together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the translocation pore.; Function: the TOM20 protein of N. crassa is a central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins.; Localization: TOM20 is an integral membrane protein in the mitochondrial outer membrane.; Remark: mitochondrial 20 kDa outer membrane protein,MOM19 protein and translocase of outer membrane 20 kDa subunit are alternative names for TOM20 in N. crassa.; Title: strong similarity to mitochondrial import receptor TOM20 - Neurospora crassa; localisation:mitochondrion; See PMID 1661031; uncharacterized protein 1751105 4983053 An08g07360 Aspergillus niger uncharacterized protein XP_001392851.1 1750428 R 5061 CDS An08g07370 4983054 join(1751449..1751848,1751929..1753204,1753257..1753619,1753767..1753869) VIII 1 NT_166524.1 Function: Exo84p of S. cerevisiae is involved in vesicle targeting and establishment of cell polarity.; Localization: Exo84p specifically localizes to the bud tip or mother/daughter connection, sites of polarized secretion.; Phenotype: Yeast cells depleted of Exo84p cannot survive. These cells are defective in invertase secretion and accumulate vesicles similar to those in the late sec mutants.; Remark: YBR102C is the systematic name for Exo84p.; Title: similarity to exocyst protein Exo84 -Saccharomyces cerevisiae; plasma membrane; See PMID 10438536; uncharacterized protein 1753869 4983054 An08g07370 Aspergillus niger uncharacterized protein XP_059601208.1 1751449 D 5061 CDS An08g07380 4983055 join(1754734..1754765,1754844..1755157,1755262..1756397,1756465..1756629) VIII 1 NT_166524.1 Remark: the ORF encoded protein also shows strong similarity to protein fragment SEQ ID NO:20088 of A. thaliana from patent number G18610.; Similarity: the ORF encoded protein also shows strong similarity to long-chain-fatty-acid-CoA ligases of different species.; Title: strong similarity to malonyl CoA synthase matB - Rhizobium trifolii; See PMID 9826185; uncharacterized protein 1756629 4983055 An08g07380 Aspergillus niger uncharacterized protein XP_001392853.1 1754734 D 5061 CDS An08g07390 4983056 complement(1756694..1757668) VIII 1 NT_166524.1 Similarity: her1 of Rhodococcus belongs to the carboxylesterase type-b family.; Title: similarity to heroin esterase her -Rhodococcus sp.; See PMID 9143135; uncharacterized protein 1757668 4983056 An08g07390 Aspergillus niger uncharacterized protein XP_001392854.1 1756694 R 5061 CDS An08g07400 4983057 complement(join(1757960..1757992,1758336..1758869,1758931..1759185,1759286..1759306,1759373..1759518,1759575..1759766,1759825..1759869,1759931..1760099)) VIII 1 NT_166524.1 Function: TNA1 of S. cerevisiae is involved in the uptake of nicotinic acid.; Localization: TNA1 of S. cerevisiae is an integral membrane protein.; Remark: YGR260W is the systematic name for TNA1 of S. cerevisiae.; Remark: the ORF encoded protein also shows similarity to allantoate permeases.; Similarity: TNA1 of S. cerevisiae belongs to the allantoate permease family.; Title: similarity to high-affinity nicotinic acid permease Tna1 - Saccharomyces cerevisiae; See PMID 10869563; uncharacterized protein 1760099 4983057 An08g07400 Aspergillus niger uncharacterized protein XP_059601209.1 1757960 R 5061 CDS An08g07410 84591739 join(1760190..1760228,1760272..1760402,1760459..1760554,1760640..1760709) VIII 1 NT_166524.1 hypothetical protein 1760709 84591739 An08g07410 Aspergillus niger hypothetical protein XP_059601210.1 1760190 D 5061 CDS An08g07420 4983059 complement(join(1761573..1767682,1767743..1768466)) VIII 1 NT_166524.1 Catalytic activity: bicarbonate + L-glutamine + H2O + 2ATP = carbamoylphosphate + L-glutamate + phosphate + 2ADP (EC 6. 3. 5. 5).; Catalytic activity: carbamoylphosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate (EC 2. 1. 3. 2).; Function: pyrABCN of A. nidulans produces N-carbamoyl-L-aspartate, the substrate of dihydroorotase.; Pathway: pyrABCN of A. nidulans catalyzes the first two steps in the pyrimidine nucleotide de novo synthesis.; Similarity: pyrABCN of A. nidulans contains an evolutionary remnant of a dihydroorotase-encoding sequence.; Title: strong similarity to multifunctional pyrimidine biosynthesis enzyme pyrABCN - Aspergillus nidulans; See PMID 10417650; uncharacterized protein 1768466 4983059 An08g07420 Aspergillus niger uncharacterized protein XP_059601211.1 1761573 R 5061 CDS An08g07430 84591740 complement(join(1770378..1770490,1770541..1770773,1770896..1771107)) VIII 1 NT_166524.1 Remark: Closest Blastp hit to product Citron-K kinase R. n. E. val. : 0. 31.; Title: weak similarity to product Citron-K kinase -Rattus norvegicus; See PMID 9697773; uncharacterized protein 1771107 84591740 An08g07430 Aspergillus niger uncharacterized protein XP_059601212.1 1770378 R 5061 CDS An08g07440 4983061 complement(1772692..1774803) VIII 1 NT_166524.1 Title: weak similarity to desaturase/cytochrome b5 protein - Ricinus communis; See PMID 9108131; uncharacterized protein 1774803 4983061 An08g07440 Aspergillus niger uncharacterized protein XP_001392859.1 1772692 R 5061 CDS An08g07450 84591741 join(1775465..1775472,1775519..1775772,1775805..1776254,1776382..1776394,1776797..1776899,1776996..1777281,1777342..1777403) VIII 1 NT_166524.1 Title: weak similarity to protein-tyrosine-phosphatase, receptor type kappa precursor, R-PTP-kappa - Mus musculus; See PMID 8474452; uncharacterized protein 1777403 84591741 An08g07450 Aspergillus niger uncharacterized protein XP_059601213.1 1775465 D 5061 CDS An08g07460 4983063 join(1778242..1778512,1778573..1779611,1779712..1781689) VIII 1 NT_166524.1 Remark: TRP2 (R. n.), the closest manual Blastp hit, shows an E. val. of 0. 001.; Remark: TRP2 from Rattus norvegicus is a candidate transduction channel for mammalian pheromone sensory signaling.; Title: similarity to transient receptor potential family member TRP2 - Rattus norvegicus; See PMID 10318963; uncharacterized protein 1781689 4983063 An08g07460 Aspergillus niger uncharacterized protein XP_001392861.3 1778242 D 5061 CDS An08g07465 4983064 1782560..1784827 VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein CAD37162.1 - Aspergillus fumigatus; uncharacterized protein 1784827 4983064 An08g07465 Aspergillus niger uncharacterized protein XP_059601214.1 1782560 D 5061 CDS An08g07470 4983065 join(1785145..1785185,1785283..1785990,1786190..1786250) VIII 1 NT_166524.1 Localization: VAMP-7 from Rattus norvegicus is most concentrated in the trans-Golgi network region of the cell as well as late endosomes and transport vesicles that do not contain the mannose-6 phosphate receptor.; Title: similarity to VAMP-7 vesicle-associated membrane protein-7 - Rattus norvegicus; See PMID 10459012; See PMID 10888671; uncharacterized protein 1786250 4983065 An08g07470 Aspergillus niger uncharacterized protein XP_001392863.3 1785145 D 5061 CDS An08g07480 4983066 join(1787454..1789530,1789631..1789926) VIII 1 NT_166524.1 Title: similarity to eyelid - Drosophila melanogaster; See PMID 9271118; uncharacterized protein 1789926 4983066 An08g07480 Aspergillus niger uncharacterized protein XP_001392864.3 1787454 D 5061 CDS An08g07485 4983067 complement(1790414..1790596) VIII 1 NT_166524.1 Remark: the annotated protein is N-terminally shorter than the matching N. crassa protein.; Title: similarity to hypothetical protein CAD21183.1 - Neurospora crassa; uncharacterized protein 1790596 4983067 An08g07485 Aspergillus niger uncharacterized protein XP_001392865.1 1790414 R 5061 CDS An08g07490 4983068 1792034..1793815 VIII 1 NT_166524.1 Remark: the A. nidulans FacB transcriptional regulator belongs to the fungal Zn(II)2Cys6 family.; Remark: the closest manual Blastp hit A. nidulans FacB shows an E. val. of 0. 002.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; See PMID 9197408; uncharacterized protein 1793815 4983068 An08g07490 Aspergillus niger uncharacterized protein XP_001392866.1 1792034 D 5061 CDS An08g07510 4983070 complement(1794968..1798279) VIII 1 NT_166524.1 Complex: MDR1 interacts with S. cervisiae Mac1 protein.; Function: S. cerevisiae Mdr1/Gyp2p is an efficient GAP (Ras- and Rho-specific GTPase-activating protein) for Ypt6p and Sec4p, that are involved in regulating different steps of exo- and endocytic transport routes.; Remark: MDR1 of S. cerevisiae is also known as MIC1 or GYP2. the systematic name is YGR100W.; Similarity: only the similarity of the ORF coded protein to the hypothetical protein SPAC4G8. 04 (S. pombe) shows a large extention.; Similarity: the predicted A. niger protein shows similarity to the MDR1 protein of S. cerevisiae, which belongs to a large family of Ypt/Rab-GAPs.; Title: similarity to protein Mdr1 - Saccharomyces cerevisiae; See PMID 10559187; uncharacterized protein 1798279 4983070 An08g07510 Aspergillus niger uncharacterized protein XP_001392868.1 1794968 R 5061 CDS An08g07520 4983071 join(1799140..1799264,1799333..1799364,1799449..1799779,1799835..1800291) VIII 1 NT_166524.1 Catalytic activity: 3-oxoacyl-(acyl carrier protein) reductases convert (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP(+) <=> 3-oxoacyl-[acyl-carrier protein] + NADPH.; Catalytic activity: the levodione reductase from C. aquaticum catalyzed regio- and stereo selective reduction of levodione to (4R,6R)-4-hydroxy-2,2,6-trimethylcyclohexanone (actinol).; Similarity: the ORF shows strong similarity to hypothetical and experimental validated 3-oxoacyl-(acyl carrier protein) reductases (EC:1. 1. 1. 100). Therefore it is not clear if the ORF encoded A. niger protein is involved in fatty acid- or in polyketid synthesis.; Title: strong similarity to levodione reductase lvr - Corynebacterium aquaticum; See PMID 10508066; uncharacterized protein 1800291 4983071 An08g07520 Aspergillus niger uncharacterized protein XP_001392869.1 1799140 D 5061 CDS An08g07530 4983072 complement(join(1800962..1802083,1802140..1802376,1802440..1803459,1803529..1803909)) VIII 1 NT_166524.1 Remark: the D. melanogaster CRAG-protein was found as Calmodulin binding factor expressed in the Drosophila retina.; Similarity: the D. melanogaster CRAG-protein is related to Rab3 GTPase exchange proteins.; Title: similarity to protein CRAG - Drosophila melanogaster; See PMID 9813038; uncharacterized protein 1803909 4983072 An08g07530 Aspergillus niger uncharacterized protein XP_059601215.1 1800962 R 5061 CDS An08g07540 4983073 complement(join(1808777..1812014,1812090..1813304,1813354..1813474,1813530..1813743)) VIII 1 NT_166524.1 Function: Pichia pastoris PER6 gene product is a peroxisomal membrane protein essential for peroxisome biogenesis and has sequence.; Title: strong similarity to protein PER6 - Pichia pastoris; peroxisome; See PMID 8993620; See PMID 8628321; uncharacterized protein 1813743 4983073 An08g07540 Aspergillus niger uncharacterized protein XP_059601216.1 1808777 R 5061 CDS An08g07550 4983074 join(1815192..1815829,1815891..1816171,1816303..1816390,1816460..1816502,1816714..1816764) VIII 1 NT_166524.1 Remark: Drosophila TRP proteins are essential for light-activated,phosphatidyl-inositide (PI)-dependent Ca2+ conductance in Drosophila photoreceptors.; Remark: the mouse TRP4 protein is a homolog of Drosophila class of TRP channels.; Title: similarity to receptor-activated cation channel TRP4 - Mus musculus; See PMID 9512398; uncharacterized protein 1816764 4983074 An08g07550 Aspergillus niger uncharacterized protein XP_059601217.1 1815192 D 5061 CDS An08g07560 4983075 join(1820623..1820629,1820659..1821416,1821487..1821491,1821540..1821792) VIII 1 NT_166524.1 Remark: the ORF coded protein also shows weak similarities to some zinc finger proteins, so it could probably be a transcription factor.; Title: similarity to hypothetical protein CAD37151.1 - Aspergillus fumigatus; uncharacterized protein 1821792 4983075 An08g07560 Aspergillus niger uncharacterized protein XP_059601218.1 1820623 D 5061 CDS An08g07570 4983076 join(1824707..1824947,1825012..1825350,1825403..1825638) VIII 1 NT_166524.1 Catalytic activity: isopentenyl diphosphate <=> dimethylallyl diphosphate.; Pathway: IDI1 gene product of S. cerevisiae is involved isoprene biosynthesis; cholesterol biosynthesis.; Title: strong similarity to isopentenyl-diphosphate Delta-isomerase Idi1 - Saccharomyces cerevisiae; See PMID 2681212; uncharacterized protein 1825638 4983076 An08g07570 Aspergillus niger uncharacterized protein XP_001392874.1 1824707 D 5061 CDS An08g07580 4983077 complement(join(1825838..1825846,1825891..1826260,1826328..1826455)) VIII 1 NT_166524.1 Remark: hypothetical protein L5075. 03 from Leishmania major is possible negative regulator of cdc42p.; Title: weak similarity to hypothetical protein L5075.03 - Leishmania major; uncharacterized protein 1826455 4983077 An08g07580 Aspergillus niger uncharacterized protein XP_059601219.1 1825838 R 5061 CDS An08g07590 4983078 join(1827485..1828193,1828250..1829415) VIII 1 NT_166524.1 Remark: the ERC1 gene product of S. cerevisiae interacts with YDL012c in vivo (see Pubmed 10688190).; Title: strong similarity to ethionine resistance protein Erc1 - Saccharomyces cerevisiae; See PMID 10688190; uncharacterized protein 1829415 4983078 An08g07590 Aspergillus niger uncharacterized protein XP_001392876.1 1827485 D 5061 CDS An08g07600 4983079 complement(join(1829601..1830362,1830438..1830538,1830663..1830666)) VIII 1 NT_166524.1 Complex: the ssb2 gene product is subunit of a complex with 68, 30, and 12 kDa chains.; Function: the ssb2 gene product from S. pombe binds single stranded sequences.; Remark: the ssb2 gene product from S. pombe becomes phosphorylated in a cell-cycle-dependent manner.; Title: strong similarity to single-stranded DNA binding protein 30k chain ssb2p - Schizosaccharomyces pombe; See PMID 8702843; uncharacterized protein 1830666 4983079 An08g07600 Aspergillus niger uncharacterized protein XP_001392877.1 1829601 R 5061 CDS An08g07610 4983080 1830958..1833756 VIII 1 NT_166524.1 Remark: DRS1=deficiency of ribosomal subunits.; Remark: the S. cerevisiae DRS1 gene product is a putative RNA helicase of the DEAD box family.; Title: strong similarity to ATP-dependent RNA helicase involved in ribosome assembly Drs1 - Saccharomyces cerevisiae; nucleus; See PMID 1454790; uncharacterized protein 1833756 4983080 An08g07610 Aspergillus niger uncharacterized protein XP_001392878.1 1830958 D 5061 CDS An08g07620 84591742 complement(join(<1834083..1834194,1834250..1834272,1834359..1834395)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein EAA63156.1 - Aspergillus nidulans [truncated ORF]; uncharacterized protein 1834395 84591742 An08g07620 Aspergillus niger uncharacterized protein XP_059606154.1 1834083 R 5061 CDS An08g07630 4983082 complement(1834772..1835767) VIII 1 NT_166524.1 Title: strong similarity to hypothetical oxidoreductase of the short-chain dehydrogenase/reductase family - Deinococcus radiodurans; uncharacterized protein 1835767 4983082 An08g07630 Aspergillus niger uncharacterized protein XP_001392880.1 1834772 R 5061 CDS An08g07640 84591743 join(<1836123..1836198,1836251..>1836580) VIII 1 NT_166524.1 hypothetical protein 1836580 84591743 An08g07640 Aspergillus niger hypothetical protein XP_059606155.1 1836123 D 5061 CDS An08g07650 84591744 join(<1837129..1837276,1837390..1837446,1837506..1837582) VIII 1 NT_166524.1 Remark: truncated ORF due to end of contig.; hypothetical protein [truncated ORF] 1837582 84591744 An08g07650 Aspergillus niger hypothetical protein [truncated ORF] XP_059606924.1 1837129 D 5061 CDS An08g07660 84591745 complement(join(1837625..1837820,1838024..1838172,1838250..1838417,1838438..1838663,1838871..1838989)) VIII 1 NT_166524.1 hypothetical protein 1838989 84591745 An08g07660 Aspergillus niger hypothetical protein XP_059606925.1 1837625 R 5061 CDS An08g07670 84591746 join(1839098..1839151,1839339..1839443,1839526..1839708,1839806..1839871) VIII 1 NT_166524.1 hypothetical protein 1839871 84591746 An08g07670 Aspergillus niger hypothetical protein XP_059606926.1 1839098 D 5061 CDS An08g07680 84591747 join(1840606..1840734,1840867..1841001,1841084..1841141,1841221..1841421,1841692..1841787,1842416..1842588) VIII 1 NT_166524.1 hypothetical protein 1842588 84591747 An08g07680 Aspergillus niger hypothetical protein XP_059606927.1 1840606 D 5061 CDS An08g07690 84591748 join(1842803..1842901,1842994..1843099,1843199..1843308) VIII 1 NT_166524.1 Remark: blastORFEmbl and blastp hits are caused by repetetive sequence motives.; hypothetical protein 1843308 84591748 An08g07690 Aspergillus niger hypothetical protein XP_059606928.1 1842803 D 5061 CDS An08g07700 84591749 complement(join(1843433..1843640,1843724..1843817,1844438..1844552,1844674..1844733,1844839..1844853)) VIII 1 NT_166524.1 Remark: unusual genestructure due to large intron.; Similarity: blastp hits might be caused by repetitive sequence motives.; Title: weak similarity to histone 1 protein H1 -Mytilus edulis; uncharacterized protein 1844853 84591749 An08g07700 Aspergillus niger uncharacterized protein XP_059606929.1 1843433 R 5061 CDS An08g07710 4983090 join(1844913..1845557,1845694..1846695) VIII 1 NT_166524.1 Title: strong similarity to hypothetical C6 hypothetical protein CAD37146.1 - Aspergillus fumigatus; uncharacterized protein 1846695 4983090 An08g07710 Aspergillus niger uncharacterized protein XP_001392888.1 1844913 D 5061 CDS An08g07720 84591750 complement(join(1846773..1846885,1846995..1847027,1847116..1847218)) VIII 1 NT_166524.1 hypothetical protein 1847218 84591750 An08g07720 Aspergillus niger hypothetical protein XP_059606930.1 1846773 R 5061 CDS An08g07730 84591751 join(1847290..1847339,1847836..1847908,1847992..1848094,1848128..1848290,1848344..1848638) VIII 1 NT_166524.1 hypothetical protein 1848638 84591751 An08g07730 Aspergillus niger hypothetical protein XP_059606931.1 1847290 D 5061 CDS An08g07740 4983093 join(1848949..1849067,1849149..1849249,1849302..1849417,1849442..1850878) VIII 1 NT_166524.1 Catalytic activity: L-phenylalanine = trans-cinnamate + NH3.; Remark: ORF might be truncated for about 120 aa due to end of contig.; Title: strong similarity to phenylalanine ammonia-lyase Pal - Rhodosporidium toruloides [truncated ORF]; See PMID 1368015; See PMID 1773059; uncharacterized protein 1850878 4983093 An08g07740 Aspergillus niger uncharacterized protein XP_059606932.1 1848949 D 5061 CDS An08g07750 84591752 <1851006..1851287 VIII 1 NT_166524.1 Remark: truncated ORF due to end of contig.; hypothetical protein [truncated ORF] 1851287 84591752 An08g07750 Aspergillus niger hypothetical protein [truncated ORF] XP_059601220.1 1851006 D 5061 CDS An08g07760 84591753 complement(join(1851499..1851523,1851607..1851746)) VIII 1 NT_166524.1 hypothetical protein 1851746 84591753 An08g07760 Aspergillus niger hypothetical protein XP_059601221.1 1851499 R 5061 CDS An08g07770 4983096 join(1852243..1852501,1852578..1852817,1852875..1852970,1853018..1853093,1853141..1853327,1853382..1853650,1853705..1853841,1853891..1854143,1854203..1854437) VIII 1 NT_166524.1 Remark: alternate name = YGR055W.; Remark: the MUP1-homologue of Aspergillus niger is probably located in the plasma membrane due to its 7 integral membrane domains.; Title: strong similarity to high affinity methionine permease Mup1 - Saccharomyces cerevisiae; See PMID 8893857; uncharacterized protein 1854437 4983096 An08g07770 Aspergillus niger uncharacterized protein XP_001392894.1 1852243 D 5061 CDS An08g07780 4983097 complement(join(1855438..1855915,1855972..1856436,1856485..1856633,1856688..1856729,1856780..1856981,1857039..1857397)) VIII 1 NT_166524.1 Title: strong similarity to lysine-specific permease lysP - Escherichia coli; See PMID 7888172; See PMID 1315732; uncharacterized protein 1857397 4983097 An08g07780 Aspergillus niger uncharacterized protein XP_059604135.1 1855438 R 5061 CDS An08g07790 4983098 complement(1858123..1860531) VIII 1 NT_166524.1 Function: DBP4 from S. cerevisiae can suppress the rRNA processing function of the U14 small nucleolar RNA.; Function: DBP4 from S. cerevisiae is predicted to function either in assembly of the U14 small nucleolar RNP or, more likely, in its interaction with other components of the rRNA processing apparatus.; Remark: DBP4 from S. cerevisiae belongs to the DEAD-DEXH box family.; Remark: an alternative name for DBP4 is CA4.; Title: strong similarity to RNA helicase Dbp4 -Saccharomyces cerevisiae; See PMID 9199348; See PMID 9747670; uncharacterized protein 1860531 4983098 An08g07790 Aspergillus niger uncharacterized protein XP_001392896.1 1858123 R 5061 CDS An08g07800 4983099 join(1860805..1860867,1860923..1860966,1861050..1861581) VIII 1 NT_166524.1 Function: human Spf31 is a nuclear DNAj-like protein which interferes with pre-mRNA splicing.; Remark: information regarding human spf31 has not been published and is available from http://www. protana. com/publics/default. asp.; Similarity: shows weak similarity to heat shock protein HSP40-3 from M. musculus.; Title: similarity to hypothetical spliceosome associated protein Spf31 - Homo sapiens; nucleus; uncharacterized protein 1861581 4983099 An08g07800 Aspergillus niger uncharacterized protein XP_001392897.1 1860805 D 5061 CDS An08g07810 4983100 1862283..1863188 VIII 1 NT_166524.1 Catalytic activity: fmn adenyltransferases convert ATP + FMN to diphosphate + FAD.; Function: Fad1p of S. cerevisiae adenylates FMN to FAD.; Localization: FAD synthetase of S. cerevisiae is a soluble cytosolic enzyme.; Remark: Fad1p is an essential gene in S. cerevisiae,null mutants are non-viable.; Title: similarity to flavin adenine dinucleotide synthase Fad1 - Saccharomyces cerevisiae; cytoplasm; See PMID 7799934; uncharacterized protein 1863188 4983100 An08g07810 Aspergillus niger uncharacterized protein XP_001392898.1 1862283 D 5061 CDS An08g07820 4983101 complement(join(1863546..1863645,1863808..1863986,1864024..1864282,1864326..1864643,1864709..1864803,1864848..1865856,1865943..1866020,1866098..1866330)) VIII 1 NT_166524.1 Localization: RBMS3 of H. sapiens mostly localizes to the cytoplasm.; Remark: MSSPs are believed to regulate DNA replication, transcription, apopotosis and cell cycle progression by interacting with the C-MYC protein.; Remark: RBMS3 of H. sapiens contains two pairs of RNA binding motifs and is closely related to the structure of the c-myc gene single-strand binding proteins (MSSPs).; Title: similarity to RNA-binding protein RBMS3 -Homo sapiens; See PMID 10675610; uncharacterized protein 1866330 4983101 An08g07820 Aspergillus niger uncharacterized protein XP_059604136.1 1863546 R 5061 CDS An08g07830 4983102 complement(join(1866576..1866668,1866983..1867246,1867343..1867762,1867818..1869724,1869793..1869971,1870019..1870458,1870553..1870651)) VIII 1 NT_166524.1 Complex: human Damaged DNA Binding protein (DDB) is a heterodimer of 48 (DDB2) and 127 kDa (DDB1) subunits.; Function: human Damaged DNA Binding protein (DDB) binds to UV damaged DNA and is involved in excision repair (directly or indirectly).; Title: similarity to damage-specific DNA binding protein DDB1 - Homo sapiens; See PMID 8530102; See PMID 10713455; uncharacterized protein 1870651 4983102 An08g07830 Aspergillus niger uncharacterized protein XP_059604137.1 1866576 R 5061 CDS An08g07840 4983103 complement(join(1871668..1871964,1872036..1873826)) VIII 1 NT_166524.1 Catalytic activity: A. niger CprA converts NADPH + 2 Ferricytochrome to NADP+ + 2 Ferrocytochrome.; Function: A. niger CprA also reduces cytochrome b5 and cytochrome c.; Function: A. niger CprA catalyzes the reduction of heme-thiolate-dependent monooxygenases and is part of the microsomal hydroxylating system.; Gene-ID: cprA; Induction: expression of A. niger CprA is induced by benzoic acid.; Mapping: cprA from A. niger is mapped to chromosome VIII; see list from DMS.; Remark: A. niger CprA is a flavoprotein, cofactors are FMN or FAD.; Remark: an alternative name for A. niger CprA is NADPH-ferrihemoprotein reductase.; Remark: some mismatches between the data bank entry and this ORF might also be due to sequencing errors.; Remark: this ORF has 5 frame shifts which might be due to sequencing errors.; endoplasmatic reticulum; See PMID 7646819; See PMID 8987724; See PMID 10852481; NADPH cytochrome P450 oxidoreductase cprA-Aspergillus niger [possible sequencing error] 1873826 cprA 4983103 cprA Aspergillus niger NADPH cytochrome P450 oxidoreductase cprA-Aspergillus niger [possible sequencing error] XP_001392901.1 1871668 R 5061 CDS An08g07850 84591754 join(1873874..1873938,1873982..1874073,1874295..1874440,1874561..1874662) VIII 1 NT_166524.1 Remark: this region is involved in benzoate induction of cprA gene expression of A. niger.; Remark: this region of A . niger is described as transcription control region of the cprA gene.; Title: questionable ORF; See PMID 10852481; uncharacterized protein 1874662 84591754 An08g07850 Aspergillus niger uncharacterized protein XP_059604138.1 1873874 D 5061 CDS An08g07860 84591755 complement(join(1874736..1875095,1875260..1875311,1875396..1875526,1875658..1875708)) VIII 1 NT_166524.1 Remark: this region is involved in benzoate induction of cprA gene expression of A. niger.; Remark: this region of A . niger is described as transcription control region of the cprA gene.; Title: questionable ORF; See PMID 10852481; uncharacterized protein 1875708 84591755 An08g07860 Aspergillus niger uncharacterized protein XP_059604139.1 1874736 R 5061 CDS An08g07870 4983106 join(1876525..1876681,1876754..1876810,1876905..1877711,1877780..1878502,1878634..1878871,1878918..1880229,1880262..1881256,1881328..1884775) VIII 1 NT_166524.1 Function: in S. cerevisiae tao3 mutants activate OCH1 transcription and form aggregates.; Remark: information regarding TAO3 has not been published and is available from http://genome-www. stanford. edu/cgi-bin/SGD/genehunter.; Title: strong similarity to transcription activator Tao3 - Saccharomyces cerevisiae; uncharacterized protein 1884775 4983106 An08g07870 Aspergillus niger uncharacterized protein XP_059604140.1 1876525 D 5061 CDS An08g07880 84591756 join(1885000..1885196,1885265..1885391) VIII 1 NT_166524.1 hypothetical protein 1885391 84591756 An08g07880 Aspergillus niger hypothetical protein XP_059604141.1 1885000 D 5061 CDS An08g07890 4983108 join(1885425..1885590,1885676..1885866,1886012..1886746) VIII 1 NT_166524.1 Catalytic activity: 3-hydroxyisobutyrate dehydrogenases convert 3-Hydroxy-2-methylpropanoate + NAD+ to 2-Methyl-3-oxopropanoate + NADH.; Function: MmsB of P. aeruginosa is an oxidoreductase, it is acting on the CH-OH group of donors with NAD+ or NADP+ as acceptor.; Pathway: P. aeruginosa MmsB is involved in valine,leucine and isoleucine biosynthesis and degradation.; Title: strong similarity to 3-hydroxyisobutyrate dehydrogenase MmsB - Pseudomonas aeruginosa; See PMID 1339433; uncharacterized protein 1886746 4983108 An08g07890 Aspergillus niger uncharacterized protein XP_001392906.1 1885425 D 5061 CDS An08g07900 4983109 join(1887250..1887848,1887931..1888047,1888149..1888211,1888341..1888521) VIII 1 NT_166524.1 Title: weak similarity to protein #2506 from patent WO200177335-A2 - Listeria monocytogenes; uncharacterized protein 1888521 4983109 An08g07900 Aspergillus niger uncharacterized protein XP_059604142.1 1887250 D 5061 CDS An08g07910 4983110 complement(join(1888568..1888686,1888752..1888869,1888915..1889555,1889624..1889845,1889909..1889944,1890008..1890323)) VIII 1 NT_166524.1 Function: PDAT9 of N. haematococca detoxifies the phytoalexin pisatin, an antimicrobial compound produced by garden pea in response to infection by this plant pathogen.; Remark: PDAT9 is associated with high virulence.; Remark: based on its amino acid sequence PDAT9 of N. haematococca has been assigned to the new cytochrome P450 family CYP57.; Remark: detoxification of pisatin in N. haematococca is controlled by a family of PDA (pisatin demethylating ability) genes.; Remark: six known PDA genes each encode characteristic levels of inducible enzyme activity and are associated with different degrees of virulence on pea.; Title: strong similarity to cytochrome P450 pisatin demethylase PDAT9 - Nectria haematococca; See PMID 8076822; See PMID 8208242; uncharacterized protein 1890323 4983110 An08g07910 Aspergillus niger uncharacterized protein XP_059604143.1 1888568 R 5061 CDS An08g07920 4983111 complement(join(1890971..1891814,1891866..1892676,1892772..1892856)) VIII 1 NT_166524.1 Catalytic activity: phenol hydroxylases convert phenol + NADPH + O2 to catechol + NADP+ + H2O.; Pathway: T. cutaneum phenol 2-monooxygenase is invovled in phenylalanine metabolism,gamma-hexachlorocyclohexane degradation, toluene degradation, first step of phenol degradation.; Remark: T. cutaneum phenol 2-monooxygenase is a flavoprotein (FAD) it is also active with resorcinol and o-cresol.; Remark: T. cutaneum phenol 2-monooxygenase is an oxidoreductase, it is acting on paired donors with incorporation of molecular oxygen with NADH or NADPH as one donor, and incorporation of one atom of oxygen.; Title: similarity to phenol 2-monooxygenase -Trichosporon beigelii; See PMID 1429434; uncharacterized protein 1892856 4983111 An08g07920 Aspergillus niger uncharacterized protein XP_059604144.1 1890971 R 5061 CDS An08g07930 4983112 complement(join(1893147..1893259,1893339..1893438,1893569..1893925,1894160..1894262,1894315..1894725,1894766..1895958,1896129..1896165,1896252..1896532,1896622..1896654)) VIII 1 NT_166524.1 Function: LAC9 of K. lactis controls induction of the lactose-galactose regulon.; Similarity: K. lactis LAC9 is structurally and functionally related to GAL4 of S. cerevisiae.; Similarity: similarity is between the central regions of the predicted A. niger protein and several transcription factors.; Title: similarity to positive regulator of the lactose-galactose regulon LAC9 - Kluyveromyces lactis; nucleus; See PMID 3550430; uncharacterized protein 1896654 4983112 An08g07930 Aspergillus niger uncharacterized protein XP_001392910.3 1893147 R 5061 CDS An08g07940 4983113 complement(join(1896694..1896848,1896947..1896995,1897077..1897206,1897481..1898034)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein CAC28695.1 - Neurospora crassa; uncharacterized protein 1898034 4983113 An08g07940 Aspergillus niger uncharacterized protein XP_001392911.3 1896694 R 5061 CDS An08g07950 4983114 join(1898328..1898509,1898584..1898617,1898709..1898780,1898830..1898921,1899030..1899128,1899259..1899487) VIII 1 NT_166524.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1899487 4983114 An08g07950 Aspergillus niger uncharacterized protein XP_059604145.1 1898328 D 5061 CDS An08g07960 4983115 join(1900094..1900177,1900234..1900267,1900321..1900569,1900629..1901194,1901249..>1901376) VIII 1 NT_166524.1 Catalytic activity: Fun49 of S. cerevisiae catalyzes the stereospecific oxidation of (2R,3R)-2,3-butanediol and meso-butanediol to (3R)-acetoin and (3S)-acetoin,respectively.; Complex: Fun49 of S. cerevisiae is a homodimer.; Function: Fun49 of S. cerevisiae is an NAD-dependent (2R,3R)-2,3-butanediol dehydrogenase acting on the CH-OH group of donors with NAD+ as acceptor.; Remark: alternative names for Fun49 of S. cerevisiae are Bdh and YAL060W.; Title: similarity to butanediol dehydrogenase Fun49 - Saccharomyces cerevisiae [putative frameshift]; putative frameshift; See PMID 10938079; uncharacterized protein 1901376 4983115 An08g07960 Aspergillus niger uncharacterized protein XP_059604146.1 1900094 D 5061 CDS An08g07980 84591757 1902442..1902732 VIII 1 NT_166524.1 hypothetical protein 1902732 84591757 An08g07980 Aspergillus niger hypothetical protein XP_059604147.1 1902442 D 5061 CDS An08g08000 4983119 complement(join(1903979..1905553,1905813..1906076)) VIII 1 NT_166524.1 Function: the MAL31 protein from yeast is a high affinity maltose/H+ symporter (maltose permease).; Remark: the MAL31 protein from yeast is a member of the hexose transporter family of the major facilitator superfamily (MFS).; Title: strong similarity to maltose transport protein Mal31 - Saccharomyces cerevisiae; See PMID 7483839; See PMID 2549370; uncharacterized protein 1906076 4983119 An08g08000 Aspergillus niger uncharacterized protein XP_001392915.3 1903979 R 5061 CDS An08g08010 4983120 1906107..1906985 VIII 1 NT_166524.1 Title: similarity to hypothetical protein MmcH -Streptomyces lavendulae; uncharacterized protein 1906985 4983120 An08g08010 Aspergillus niger uncharacterized protein XP_001392916.1 1906107 D 5061 CDS An08g08020 4983121 1907632..1908648 VIII 1 NT_166524.1 Function: bah of S. hygroscopicus is also involved in self defence agianst bialaphos.; Function: bah of S. hygroscopicus removes the N-acetyl group from bialaphos (antibiotic) and is one of the final steps in the bialaphos biosynthetic pathway.; Title: similarity to bialaphos acetylhydrolase bah -Streptomyces hygroscopicus; See PMID 3209476; uncharacterized protein 1908648 4983121 An08g08020 Aspergillus niger uncharacterized protein XP_001392917.3 1907632 D 5061 CDS An08g08030 4983122 complement(1909385..1911061) VIII 1 NT_166524.1 Catalytic activity: pnbA of B. subtilis converts a carboxylic ester + H2O to alcohol + carboxylate.; Function: pnbA of B. subtilis is involved in the biosynthesis of betalactam antibiotics.; Title: strong similarity to para-nitrobenzyl esterase pnbA - Bacillus subtilis; See PMID 7828905; uncharacterized protein 1911061 4983122 An08g08030 Aspergillus niger uncharacterized protein XP_001392918.1 1909385 R 5061 CDS An08g08040 4983123 complement(join(1911223..1911280,1911360..1911400,1911477..1911596,1911938..1913146,1913196..1913495)) VIII 1 NT_166524.1 Remark: similarity to S. pombe SPBC1105. 07c is restricted to the N-terminal part of the protein.; Title: similarity to hypothetical protein SPBC1105.07c - Schizosaccharomyces pombe; uncharacterized protein 1913495 4983123 An08g08040 Aspergillus niger uncharacterized protein XP_001392919.3 1911223 R 5061 CDS An08g08050 84591758 join(1913531..1913650,1913751..1913837,1913922..1914102,1914147..1914214,1914341..1914415,1914532..1914621,1914749..1914982) VIII 1 NT_166524.1 Remark: ORF classified questionable due to implausible gene structure with short, multiple Exons and no significant blastp similarity.; Title: questionable ORF; uncharacterized protein 1914982 84591758 An08g08050 Aspergillus niger uncharacterized protein XP_059604148.1 1913531 D 5061 CDS An08g08060 4983125 join(1915291..1915578,1915634..1916899) VIII 1 NT_166524.1 Catalytic activity: N,N-Dimethylaniline + NADPH + O2 = N,N-Dimethylaniline N-oxide + NADP+ + H2O.; Remark: FMO appears to be ideally adapted to catalyse the detoxification of structurally diverse soft nucleophiles (e. g. alkaloids with basic side-chains and organic sulfur xenobiotics) so abundant in food derived from plants.; Remark: flavin-containing monooxygenases (FMOs) have been identified in various organisms from bacteria to humans.; Remark: similar to patent W49699 Human flavin-containing mono-oxygenase 2.; Title: strong similarity to flavin-containing monooxygenase FMO5 - Cavia porcellus; See PMID 7872795; See PMID 9972460; See PMID 2203193; uncharacterized protein 1916899 4983125 An08g08060 Aspergillus niger uncharacterized protein XP_001392921.1 1915291 D 5061 CDS An08g08070 4983126 complement(join(1917261..1917403,1917555..1919106)) VIII 1 NT_166524.1 Remark: seladin-1 is a human homolog of the DIMINUTO/DWARF1 gene described in plants and Caenorhabditis elegans. Its sequence shares similarities with flavin-adenin-dinucleotide (FAD)-dependent oxidoreductases.; Remark: seladin-1 is an important factor for the protection of cells against Abeta toxicity and oxidative stress, and they suggest that seladin-1 may be involved in the regulation of cell survival and death.; Remark: the Arabidopsis DIMINUTO/DWARF1 gene encodes a protein involved in steroid synthesis.; Title: strong similarity to seladin-1 - Homo sapiens; See PMID 11007892; uncharacterized protein 1919106 4983126 An08g08070 Aspergillus niger uncharacterized protein XP_059604149.1 1917261 R 5061 CDS An08g08080 4983127 complement(join(1919275..1920763,1920822..1921015,1921074..1921284,1921354..1921457)) VIII 1 NT_166524.1 Catalytic activity: a 5'-Ribonucleotide + H2O = a Ribonucleoside + Orthophosphate.; Pathway: Purine metabolism; Pyrimidine metabolism; Nicotinate and nicotinamide metabolism.; Remark: there are 5-7 domains highly conserved in procaryotes and vertebrates in enzymes exhibiting 5'-nucleotidase, 3'-nucleotidase or phosphodiesterase activity.; Title: strong similarity to 5-nucleotidase 5NTD_DISOM - Discopyge ommata; See PMID 10506947; See PMID 1765099; uncharacterized protein 1921457 4983127 An08g08080 Aspergillus niger uncharacterized protein XP_001392923.1 1919275 R 5061 CDS An08g08090 4983128 complement(join(1921780..1922091,1922157..1922340,1922400..1922446,1922516..1922593,1922655..1922885)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein CAD21290.1 - Neurospora crassa; uncharacterized protein 1922885 4983128 An08g08090 Aspergillus niger uncharacterized protein XP_001392924.3 1921780 R 5061 CDS An08g08100 4983129 complement(join(1923436..1923819,1923882..1924158,1924217..>1924629)) VIII 1 NT_166524.1 Remark: N-terminal truncated ORF due to end of contig.; Remark: the protein shows weak similarity to different zinc finger containing transcription activators in different organisms.; Title: similarity to hypothetical transcriptional regulator CAF32162.1 - Aspergillus fumigatus [truncated ORF]; uncharacterized protein 1924629 4983129 An08g08100 Aspergillus niger uncharacterized protein XP_001392925.3 1923436 R 5061 CDS An08g08110 84591759 complement(<1924771..1925692) VIII 1 NT_166524.1 Remark: C-terminal truncated orf due to end of contig.; Similarity: shows strong similarity to C-terminal half of An06g00330.; Title: similarity to hypothetical protein encoded by An06g00330 - Aspergillus niger [truncated ORF]; uncharacterized protein 1925692 84591759 An08g08110 Aspergillus niger uncharacterized protein XP_059601222.1 1924771 R 5061 CDS An08g08120 4983131 join(1927895..1927902,1927955..1928174,1928227..1928418) VIII 1 NT_166524.1 Title: similarity to hypothetical protein sll0676 -Synechocystis sp.; uncharacterized protein 1928418 4983131 An08g08120 Aspergillus niger uncharacterized protein XP_001392927.1 1927895 D 5061 CDS An08g08130 4983132 complement(1928646..1929857) VIII 1 NT_166524.1 Title: weak similarity to hypothetical ankyrin-like protein T22P11_210 - Arabidopsis thaliana; uncharacterized protein 1929857 4983132 An08g08130 Aspergillus niger uncharacterized protein XP_059601223.1 1928646 R 5061 CDS An08g08140 4983133 join(1931357..1931667,1931726..1931765,1931825..1932798,1932864..1933165,1933282..1933286,1933394..1933408) VIII 1 NT_166524.1 Catalytic activity: Digallate + H2O = 2 Gallate.; Remark: tannase consisted of two kinds of subunits,linked by a disulfide bond(s) with molecular weights of about 30,000 and 33,000, respectively.; Remark: the tannase gene product is translated as a single polypeptide that is cleaved by post-translational modification into two tannase subunits linked by a disulfide bond(s).; Remark: this enzyme hydrolyzes the ester bonds of tannic acid to produce gallic acid and glucose.; Title: strong similarity to precursor of tannase -Aspergillus oryzae; See PMID 8917102; uncharacterized protein 1933408 4983133 An08g08140 Aspergillus niger uncharacterized protein XP_001392929.3 1931357 D 5061 CDS An08g08150 4983134 complement(join(1933620..1935429,1935488..1935623,1935827..1935860)) VIII 1 NT_166524.1 Title: weak similarity to hypothetical protein T8B10.110 - Arabidopsis thaliana; uncharacterized protein 1935860 4983134 An08g08150 Aspergillus niger uncharacterized protein XP_059601224.1 1933620 R 5061 CDS An08g08160 84591760 join(1937585..1937797,1937929..1938180) VIII 1 NT_166524.1 Remark: there is a small domain wich is shows similarity to c terminal region of beta transducin-like protein - Podospora anserina.; Title: similarity to hypothetical protein EAA66849.1 - Aspergillus nidulans; uncharacterized protein 1938180 84591760 An08g08160 Aspergillus niger uncharacterized protein XP_059601225.1 1937585 D 5061 CDS An08g08180 84591761 join(1939251..1939282,1939414..1939543) VIII 1 NT_166524.1 Title: questionable ORF; uncharacterized protein 1939543 84591761 An08g08180 Aspergillus niger uncharacterized protein XP_059601226.1 1939251 D 5061 CDS An08g08190 4983137 complement(join(1940916..1941069,1941119..1941402,1941450..1941559,1941616..1941697,1941747..1941872,1941919..1942248)) VIII 1 NT_166524.1 Remark: the 3,6-dideoxyhexoses are found in the lipopolysaccharides of gram-negative bacteria, where they have been shown to be the dominant antigenic determinants. Of the five 3,6-dideoxyhexoses known to occur naturally,four have been found in various strains of Salmonella enterica (abequose, tyvelose, paratose, and colitose).; Title: weak similarity to CDP-3,6-dideoxy-L-glycero-D-glycero-4-hexulose-4-reductase -Yersinia pseudotuberculosis; See PMID 8071227; uncharacterized protein 1942248 4983137 An08g08190 Aspergillus niger uncharacterized protein XP_059601227.1 1940916 R 5061 CDS An08g08200 4983138 complement(join(1942887..1942901,1942981..1943110,1943316..1943593)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein encoded by An14g02850 - Aspergillus niger; uncharacterized protein 1943593 4983138 An08g08200 Aspergillus niger uncharacterized protein XP_059601228.1 1942887 R 5061 CDS An08g08210 4983139 1944286..1945368 VIII 1 NT_166524.1 Remark: human actVA-ORF4-like protein useful in the treatment of infectious, vesicle trafficking, immunological and neoplastic disorders.; Remark: patent Y14147.; Remark: the similarity is only in the N-terminal region until aa 180; Title: weak similarity to human actVA-ORF4-like protein from patent WO9911793-A1 - Homo sapiens; uncharacterized protein 1945368 4983139 An08g08210 Aspergillus niger uncharacterized protein XP_059601229.1 1944286 D 5061 CDS An08g08220 4983140 join(1947416..1948728,1948786..1949077) VIII 1 NT_166524.1 Remark: ATR1 encodes a Myb-like transcription factor that modulates ASA1 expression.; Remark: Expression of yeast ATR1 is enhanced in the presence of constitutively active alleles of YAP1 and GCN4.; Title: strong similarity to aminotriazole resistance protein Atr1 - Saccharomyces cerevisiae; plasma membrane; See PMID 9046086; See PMID 9576939; uncharacterized protein 1949077 4983140 An08g08220 Aspergillus niger uncharacterized protein XP_001392936.1 1947416 D 5061 CDS An08g08230 4983141 join(1950829..1951163,1951215..1958956,1959025..1959794,1959851..1960564) VIII 1 NT_166524.1 Title: weak similarity to hypothetical protein CAC01058.1 - Leishmania major; uncharacterized protein 1960564 4983141 An08g08230 Aspergillus niger uncharacterized protein XP_059601230.1 1950829 D 5061 CDS An08g08240 4983142 join(1962615..1963136,1963221..1964451,1964555..1965045) VIII 1 NT_166524.1 Catalytic activity: Hydrolysis of terminal,non-reducing beta-D-glucose residues with release of beta-D-glucose.; Remark: BGLN showed maximum activity against the artificial substrate p-nitrophenyl beta-D-glucopyranoside.; Remark: It also hydrolyzed salicin, p-nitrophenyl beta-D-xyloside, cellobiose, and arbutin to a lesser extent. Fructose and SO(2) did not affect enzyme activity,which was activated by ethanol, while glucose was a strong competitive inhibitor.; Remark: strong similarity to Tomatinase Patent R85197.; Title: strong similarity to beta-glucosidase bgln -Candida molischiana; See PMID 10554245; See PMID 11137391; uncharacterized protein 1965045 4983142 An08g08240 Aspergillus niger uncharacterized protein XP_059601231.1 1962615 D 5061 CDS An08g08250 4983143 join(1966366..1966605,1966652..1968265) VIII 1 NT_166524.1 Remark: Aryl-alcohol oxidase (AAO) involved in lignin degradation by Pleurotus pulmonarius shows compared with other alcohol oxidases, 35% amino acid identity with glucose oxidase, showed highly conserved amino acid sequences in N-terminal and C-terminal regions, in spite of differences in substrate specificity.; Remark: it also shows strong similarity to glucose oxidase ggox Aspergillus niger.; Remark: the enzyme uses oxygen as an acceptor to produce hydrogen peroxide from primary aromatic or poly-unsaturated aliphatic alcohols.; Title: strong similarity to aryl-alcohol oxidase precursor aao - Pleurotus pulmonarius; See PMID 8987726; See PMID 10606774; uncharacterized protein 1968265 4983143 An08g08250 Aspergillus niger uncharacterized protein XP_001392939.1 1966366 D 5061 CDS An08g08260 4983144 complement(join(1968684..1968760,1969042..1969109,1969166..1969509)) VIII 1 NT_166524.1 hypothetical protein 1969509 4983144 An08g08260 Aspergillus niger hypothetical protein XP_059601232.1 1968684 R 5061 CDS An08g08280 4983146 complement(join(1972288..1973265,1973328..1973507)) VIII 1 NT_166524.1 Remark: only the homeobox domain shows this similarity.; Remark: the similarity is to different homeobox proteins.; Title: weak similarity to homeobox protein slouch slou - Drosophila melanogaster; See PMID 10395544; See PMID 1980118; uncharacterized protein 1973507 4983146 An08g08280 Aspergillus niger uncharacterized protein XP_001392941.1 1972288 R 5061 CDS An08g08290 4983147 complement(join(1975483..1976562,1976625..1977287)) VIII 1 NT_166524.1 Catalytic activity: Triacylglycerol + H2O = Diacylglycerol + a Carboxylate; Diacylglycerol + H2O = Monoacylglycerol + a Carboxylate.; Pathway: Glycerolipid metabolism.; Remark: the cephalosporin esterase from Rhodosporidium torulo has EC 3. 1. 1. 41.; Title: strong similarity to cephalosporin esterase -Rhodosporidium toruloides; See PMID 9406399; See PMID 10878123; uncharacterized protein 1977287 4983147 An08g08290 Aspergillus niger uncharacterized protein XP_059601233.1 1975483 R 5061 CDS An08g08300 4983148 complement(join(1977848..1978163,1978240..1978409,1978462..1978880,1978936..1979266)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical conserved protein PA2682 - Pseudomonas aeruginosa; uncharacterized protein 1979266 4983148 An08g08300 Aspergillus niger uncharacterized protein XP_001392943.1 1977848 R 5061 CDS An08g08310 4983149 complement(join(1979744..1979867,1979922..1980997,1981064..1981285)) VIII 1 NT_166524.1 Remark: involved in mitomycin resistance; oxidizes reduced form of mitomycins.; Similarity: to other oxygen oxidoreductases in different organisms that covalently bind FAD.; Title: strong similarity to mitomycin C resistance protein mcrA - Streptomyces lavendulae; See PMID 8917108; See PMID 10468636; See PMID 7517396; uncharacterized protein 1981285 4983149 An08g08310 Aspergillus niger uncharacterized protein XP_001392944.1 1979744 R 5061 CDS An08g08320 4983150 1982251..1983222 VIII 1 NT_166524.1 Title: weak similarity to transcription factor disco - Drosophila melanogaster; uncharacterized protein 1983222 4983150 An08g08320 Aspergillus niger uncharacterized protein XP_001392945.1 1982251 D 5061 CDS An08g08330 4983151 complement(join(1983331..1983645,1983716..1984423,1984473..1984568,1984620..1984704,1984824..1985032,1985073..1985214,1985261..1985271,1985332..1985355)) VIII 1 NT_166524.1 Remark: selection for the ability of S. cerevisiae cells to take up histidinol, the biosynthetic precursor to histidine, results in dominant mutations at HOL1.; Title: strong similarity to multidrug resistance protein Hol1 - Saccharomyces cerevisiae; plasma membrane; See PMID 8955402; See PMID 10874120; uncharacterized protein 1985355 4983151 An08g08330 Aspergillus niger uncharacterized protein XP_059601234.1 1983331 R 5061 CDS An08g08340 4983152 complement(join(1986030..1986072,1986136..1986147,1986201..1987091,1987163..1987630,1987689..1988185,1988271..1988418,1988519..1988620,1988668..1988840)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein encoded by An07g02880 - Aspergillus niger; uncharacterized protein 1988840 4983152 An08g08340 Aspergillus niger uncharacterized protein XP_059601235.1 1986030 R 5061 CDS An08g08350 84591762 1989158..1990873 VIII 1 NT_166524.1 Remark: immunoglobulin variable region used by the ITC63B heavy chain (subgroup VH5).; Title: weak similarity to immunoglobulin variable region - Homo sapiens; uncharacterized protein 1990873 84591762 An08g08350 Aspergillus niger uncharacterized protein XP_059601236.1 1989158 D 5061 CDS An08g08360 84591763 join(1992388..1992722,1992776..1993152,1993215..1993282) VIII 1 NT_166524.1 Similarity: shows strong similarity to N-terminal half of An08g08380 .; Title: weak similarity to hypothetical protein encoded by An08g08380 - Aspergillus niger; uncharacterized protein 1993282 84591763 An08g08360 Aspergillus niger uncharacterized protein XP_059601237.1 1992388 D 5061 CDS An08g08370 4983155 complement(join(1993644..1994220,1994275..1994958,1995007..1995836,1995889..1995977,1996051..1996083,1996139..1996274)) VIII 1 NT_166524.1 Function: the 1,2-alpha-D-mannosidase aman2 from Bacillus sp. M-90 is an exo-1,2-alpha-D-mannanase. It is highly specific for alpha 1,2-linked D-mannose oligosaccharides.; Similarity: the ORF DNA sequence shows strong similarity to the EST an_1842 Aspergillus niger.; Title: similarity to alpha-1,2-mannosidase aman2 -Bacillus sp.; See PMID 8149382; uncharacterized protein 1996274 4983155 An08g08370 Aspergillus niger uncharacterized protein XP_059601238.1 1993644 R 5061 CDS An08g08380 4983156 complement(join(1996959..1997157,1997218..1997897,1998245..1998557,1998667..1999058)) VIII 1 NT_166524.1 Similarity: N-terminal half shows strong similarity to An08g08360.; Title: weak similarity to hypothetical protein encoded by An08g08360 - Aspergillus niger; uncharacterized protein 1999058 4983156 An08g08380 Aspergillus niger uncharacterized protein XP_001392951.3 1996959 R 5061 CDS An08g08390 84591764 join(1999545..1999561,1999645..1999845,1999908..2000015,2000071..2000303,2000414..2000677,2000736..2000866) VIII 1 NT_166524.1 Title: strong similarity to lipase LipP -Pseudomonas sp.; See PMID 9464382; uncharacterized protein 2000866 84591764 An08g08390 Aspergillus niger uncharacterized protein XP_059601239.1 1999545 D 5061 CDS An08g08400 4983158 complement(join(2000914..2001097,2001176..2001258,2001328..2001528,2001582..2001875)) VIII 1 NT_166524.1 Function: TsaC from Comamonas testosteroni T-2 catalyzes the conversion of 4-sulfobenzyl alcohol or 4-carboxybenzyl alcohol to the corresponding aldehyde.; Title: strong similarity to toluenesulfonate zinc-independent alcohol dehydrogenase TsaC - Comamonas testosteroni; See PMID 9006050; uncharacterized protein 2001875 4983158 An08g08400 Aspergillus niger uncharacterized protein XP_001392953.1 2000914 R 5061 CDS An08g08410 4983159 complement(join(2002145..2002748,2002802..2003368,2003422..2003540,2003615..2003660,2003815..2004143)) VIII 1 NT_166524.1 Title: weak similarity to Arg/Abl-interacting protein ArgBP2b - Homo sapiens; uncharacterized protein 2004143 4983159 An08g08410 Aspergillus niger uncharacterized protein XP_001392954.3 2002145 R 5061 CDS An08g08420 84591765 2004890..2005318 VIII 1 NT_166524.1 hypothetical protein 2005318 84591765 An08g08420 Aspergillus niger hypothetical protein XP_059601240.1 2004890 D 5061 CDS An08g08430 4983161 join(2005895..2005987,2006142..2006177,2006207..2006563,2006613..2008082,2008140..2008646) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein SCF41.31c - Streptomyces coelicolor; uncharacterized protein 2008646 4983161 An08g08430 Aspergillus niger uncharacterized protein XP_059601241.1 2005895 D 5061 CDS An08g08440 84591766 join(2008743..2009246,2009409..2009626,2009676..2010087) VIII 1 NT_166524.1 Catalytic activity: N nucleoside triphosphate <=> N diphosphate + {RNA}(N).; Remark: the origin and the actual biological function(s) of plant-encoded RdRP have remained unresolved and are enigmatic because its cognate template(s) and in vivo transcription products remain unknown. Cellular RdRPs differ from virus RNA replicases.; Title: similarity to RNA-directed RNA polymerase RdRP - Lycopersicon esculentum; See PMID 9836747; uncharacterized protein 2010087 84591766 An08g08440 Aspergillus niger uncharacterized protein XP_059601242.1 2008743 D 5061 CDS An08g08450 4983163 complement(join(2011274..2011647,2011703..2013113)) VIII 1 NT_166524.1 Catalytic activity: 4 benzenediol + O(2) <=> 4 benzosemiquinone + 2 H(2)O.; Cofactor: Copper.; Function: the Laccase II (lac2) from Podospora anserina is involved in lignin degradation and in the detoxification of lignin-derived products in its natural habitat (herbivorous dung), which is rich in lignin of grasses and straw. It is probably involved in melanin synthesis and in perithecia development.; Title: strong similarity to laccase II lac2 -Podospora anserina; See PMID 14600; See PMID 8914515; uncharacterized protein 2013113 4983163 An08g08450 Aspergillus niger uncharacterized protein XP_001392958.1 2011274 R 5061 CDS An08g08460 84591767 complement(join(2014350..2014449,2014490..2014568,2014642..2014695,2015054..2015167,2015215..2015323,2015412..2015513,2015684..2015803)) VIII 1 NT_166524.1 Title: weak similarity to human LYST-2 protein from patent WO9951741-A2 - Homo sapiens; uncharacterized protein 2015803 84591767 An08g08460 Aspergillus niger uncharacterized protein XP_059601243.1 2014350 R 5061 CDS An08g08470 4983165 join(2017047..2017093,2017209..2017335,2017522..2018949) VIII 1 NT_166524.1 Title: similarity to hypothetical transcription regulator SPAC18G6.01c - Schizosaccharomyces pombe; uncharacterized protein 2018949 4983165 An08g08470 Aspergillus niger uncharacterized protein XP_059601244.1 2017047 D 5061 CDS An08g08480 4983166 join(2019153..2019228,2019276..2019334,2019382..2019756,2019810..2020007,2020086..2020169) VIII 1 NT_166524.1 Catalytic activity: R-CHOH-R' + NADP(+) <=> R-CO-R' + NADPH.; Remark: the carbonyl reductase from Candida magnoliae is also described in patent WO9835025-A1.; Similarity: the ORF encoded protein shows also strong similarity to the functionally less characterized dehydrogenases Sou2 and Sou1 from C. albicans. C. albicans Sou(-) mutants are unable to utilize L-sorbose.; Title: strong similarity to NADPH-dependent carbonyl reductase S1 - Candida magnoliae; See PMID 10945260; uncharacterized protein 2020169 4983166 An08g08480 Aspergillus niger uncharacterized protein XP_001392961.1 2019153 D 5061 CDS An08g08490 4983167 join(2021299..2021456,2021524..2021760,2021807..2022296) VIII 1 NT_166524.1 Catalytic activity: phosphatidylcholine + H(2)O <=> 1-acylglycerophosphocholine + a fatty acid anion.; Title: similarity to calcium-independent phospholipase A2 - Homo sapiens; See PMID 10833412; uncharacterized protein 2022296 4983167 An08g08490 Aspergillus niger uncharacterized protein XP_001392962.3 2021299 D 5061 CDS An08g08500 4983168 join(2022939..2023015,2023149..2023350) VIII 1 NT_166524.1 Title: similarity to hypothetical DNA-binding protein SCF43A.34c - Streptomyces coelicolor; uncharacterized protein 2023350 4983168 An08g08500 Aspergillus niger uncharacterized protein XP_059601245.1 2022939 D 5061 CDS An08g08510 4983169 complement(join(2025678..2026484,2026545..2026692,2026731..2027254,2027318..2027350)) VIII 1 NT_166524.1 Catalytic activity: the aldh3 protein preferentially oxidizes aromatic aldehyde + NADP(+) + H2O = acid + NADPH.; Complex: the class 3 aldehyde dehydrogenase of H. sapiens forms a homodimer.; Function: aldehyde dehydrogenases are involved in the metabolism of corticosteroids, biogenic amines,neurotransmitters, and lipip aldehyde substrat peroxidation.; Function: aldehyde dehydrogenases play a major role in the detoxification of alcohol-derived acetaldehyde.; Remark: aldh3 of H. sapiens is a NADP-preferring aldehyde dehydrogenase.; Similarity: the predicted ORF overlaps with EST BE760482 of A. niger.; Title: strong similarity to aldehyde dehydrogenase aldh3 - Homo sapiens; cytoplasm; See PMID 8493892; See PMID 1737758; uncharacterized protein 2027350 4983169 An08g08510 Aspergillus niger uncharacterized protein XP_059606156.1 2025678 R 5061 CDS An08g08520 4983170 complement(join(2027628..2027737,2027815..2028101,2028176..2028522,2028584..2029254,2029312..2029450)) VIII 1 NT_166524.1 Function: hexose transporter family proteins of S. cerevisiae function in the cellular uptake of glucose.; Remark: alternate names for hxt17 are N3615 and YNR072w.; Remark: the hxt17 of S. cerevisiae belongs to the MAL61 superfamily of maltose transport proteins.; Similarity: the predicted ORF shows similarity to several members of the hexose facilitator family of S. cerevisiae.; Title: strong similarity to hexose transporter Hxt17 - Saccharomyces cerevisiae; plasma membrane; See PMID 10336421; uncharacterized protein 2029450 4983170 An08g08520 Aspergillus niger uncharacterized protein XP_001392965.1 2027628 R 5061 CDS An08g08530 4983171 join(2030058..2030413,2030478..2031831) VIII 1 NT_166524.1 Catalytic activity: a phenol sulfate + H(2)O = a phenol + sulfate.; Phenotype: ats mutants lose the ability to grow on aromatic sulfates as sole sulfur source.; Repression: synthesis of atsA is repressed when sulfate, cysteine or thiocyanate is supplied as the sole sulfur source for growth.; Title: strong similarity to arylsulfatase atsA -Pseudomonas aeruginosa; See PMID 7744061; See PMID 9748219; uncharacterized protein 2031831 4983171 An08g08530 Aspergillus niger uncharacterized protein XP_001392966.1 2030058 D 5061 CDS An08g08540 4983172 complement(join(2032117..2033467,2033514..2033870,2033929..2034539,2034595..2034984)) VIII 1 NT_166524.1 Function: GAPCenA is a GTPase activating protein for Rab6.; Localization: immunofluorescence and cell fractionation experiments show that GAPCenA is mainly cytosolic but that a minor pool is associated with the centrosome.; Pathway: GAPCenA may be involved in the coordination of microtubule and Golgi dynamics during the cell cycle.; Remark: the Rab6 GTPase regulates intracellular transport at the level of the Golgi apparatus.; Similarity: GAPCenA displays similarities, within a central 200 amino acids domain, to both the yeast Rab GTPase activating proteins (GAPs) and to the spindle checkpoint proteins S. cerevisiae Bub2p and Schizosaccharomyces pombe Cdc16p.; Title: strong similarity to Rab6 GTPase activating protein GAPCenA - Homo sapiens; See PMID 10202141; uncharacterized protein 2034984 4983172 An08g08540 Aspergillus niger uncharacterized protein XP_001392967.1 2032117 R 5061 CDS An08g08550 4983173 join(2037231..2037305,2037368..2037721,2037761..2040730,2040790..2042529) VIII 1 NT_166524.1 Function: top2 acts both as an enzyme and a structural component of the nuclear matrix where it regulates the topological states of DNA by transient cleavage, strand passing and re-ligation of double stranded DNA.; Remark: the action of top2 results in the decatenation of intertwined DNA molecules and relaxation of supercoiled DNA.; Remark: top2 has a role in DNA replication and is required for both condensation and segregation of chromosomes.; Title: strong similarity to DNA topoisomerase II top2 - Aspergillus nidulans; See PMID 9552399; See PMID 10452949; uncharacterized protein 2042529 4983173 An08g08550 Aspergillus niger uncharacterized protein XP_059606157.1 2037231 D 5061 CDS An08g08560 4983174 join(2043025..2044185,2044357..2044458,2044522..2044839) VIII 1 NT_166524.1 Function: FLU1 is a novel multidrug efflux transporter gene of the major facilitator superfamily from Candida albicans conferring resistance to fluconazole.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353; uncharacterized protein 2044839 4983174 An08g08560 Aspergillus niger uncharacterized protein XP_059606158.1 2043025 D 5061 CDS An08g08570 4983175 complement(join(2045265..2045449,2045530..2045585,2045771..2046503,2046550..2046634,2046684..2046799,2046856..2047177)) VIII 1 NT_166524.1 Title: weak similarity to transcription repressor Xbp1 - Saccharomyces cerevisiae; uncharacterized protein 2047177 4983175 An08g08570 Aspergillus niger uncharacterized protein XP_001392970.3 2045265 R 5061 CDS An08g08580 84591768 join(2047274..2047386,2047656..2047777,2047855..2047943,2047989..2048090,2048289..2048388,2048458..2048585,2048649..2048746,2049059..2049115,2049196..2049410,2049483..2049547,2049647..2049733) VIII 1 NT_166524.1 hypothetical protein 2049733 84591768 An08g08580 Aspergillus niger hypothetical protein XP_059606159.1 2047274 D 5061 CDS An08g08590 4983177 complement(join(2051058..2051636,2051692..2054781,2054840..2054930,2054989..2055167)) VIII 1 NT_166524.1 Function: INCENP transports certain cytoskeletal proteins to the metaphase plate so that these proteins are able to subsequently participate in the assembly of the anaphase spindle and the cleavage furrow.; Remark: an internal 200 amino acid coiled-coil domain is required for binding of INCENP to cytoplasmic microtubules.; Remark: the amino-terminal 42-amino acid residues are required for transfer of INCENP from the chromosomes to the mitotic spindle at anaphase.; Title: similarity to class II inner centromere protein INCENP - Gallus gallus; See PMID 8408220; uncharacterized protein 2055167 4983177 An08g08590 Aspergillus niger uncharacterized protein XP_059606160.1 2051058 R 5061 CDS An08g08600 4983178 join(2056824..2056860,2057009..2057023,2057116..2057226,2057279..2057310,2057365..2057482,2057545..2057741,2057801..2058268) VIII 1 NT_166524.1 Remark: Disruption of the cwl1+ gene in S. pombe caused no noticeable phenotype.; Remark: Overexpression of the cwl1+ gene in S. pombe causes cell lysis when it is overexpressed in the absence of an osmotic stabilizer.; Title: similarity to protein cwl1p -Schizosaccharomyces pombe; See PMID 8873452; uncharacterized protein 2058268 4983178 An08g08600 Aspergillus niger uncharacterized protein XP_001392973.1 2056824 D 5061 CDS An08g08620 4983180 complement(join(2060618..2061357,2061413..2061695)) VIII 1 NT_166524.1 Title: similarity to hypothetical Ydr124wp-like protein - Pneumocystis carinii; uncharacterized protein 2061695 4983180 An08g08620 Aspergillus niger uncharacterized protein XP_059606161.1 2060618 R 5061 CDS An08g08630 84591769 join(2061711..2061861,2061908..2062060,2062165..2062256,2062297..2062406,2062445..2062577,2062680..2063088,2063348..2063496) VIII 1 NT_166524.1 hypothetical protein 2063496 84591769 An08g08630 Aspergillus niger hypothetical protein XP_059606162.1 2061711 D 5061 CDS An08g08640 84591770 complement(join(2063503..2063781,2063861..2064026,2064184..2064425,2064540..2064701)) VIII 1 NT_166524.1 hypothetical protein 2064701 84591770 An08g08640 Aspergillus niger hypothetical protein XP_059606163.1 2063503 R 5061 CDS An08g08650 84591771 join(2065348..2065437,2065487..2065633,2065881..2065982,2066027..2066071) VIII 1 NT_166524.1 hypothetical protein 2066071 84591771 An08g08650 Aspergillus niger hypothetical protein XP_059606164.1 2065348 D 5061 CDS An08g08660 4983184 join(2067108..2067348,2067563..2068434) VIII 1 NT_166524.1 Title: weak similarity to hypothetical microtubule-membrane-linker p210 - Spermatozopsis similis; uncharacterized protein 2068434 4983184 An08g08660 Aspergillus niger uncharacterized protein XP_059606165.1 2067108 D 5061 CDS An08g08670 4983185 join(2069213..2070010,2070076..2072376,2072438..2072635,2072708..2072881) VIII 1 NT_166524.1 Title: strong similarity to hypothetical signaling-associated PDZ domain containing protein CAB72237.1 - Schizosaccharomyces pombe; uncharacterized protein 2072881 4983185 An08g08670 Aspergillus niger uncharacterized protein XP_001392979.3 2069213 D 5061 CDS An08g08680 84591772 complement(join(2074271..2075392,2075448..2075504)) VIII 1 NT_166524.1 Title: weak similarity to merozoite surface protein 1 MSP1 - Plasmodium cynomolgi; uncharacterized protein 2075504 84591772 An08g08680 Aspergillus niger uncharacterized protein XP_059606166.1 2074271 R 5061 CDS An08g08690 4983187 complement(join(2076663..2077378,2077429..2077481,2077527..2077701,2077776..2078070)) VIII 1 NT_166524.1 Function: Cns1 of S. cerevisiae is an essential protein associated with the hsp90 chaperone complex.; Title: strong similarity to cyclophilin seven suppressor Cns1 - Saccharomyces cerevisiae; See PMID 9819421; See PMID 9819422; See PMID 9990037; See PMID 11604493; uncharacterized protein 2078070 4983187 An08g08690 Aspergillus niger uncharacterized protein XP_059606167.1 2076663 R 5061 CDS An08g08700 84591773 join(2079121..2081029,2081161..2081222,2081325..2081357) VIII 1 NT_166524.1 Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: weak similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942; uncharacterized protein 2081357 84591773 An08g08700 Aspergillus niger uncharacterized protein XP_059606168.1 2079121 D 5061 CDS An08g08710 4983189 2081802..2083343 VIII 1 NT_166524.1 Function: ATR1 is a S. cerevisiae gene encoding a transmembrane protein required for aminotriazole resistance.; Induction: ATR1 transcription is induced by aminotriazole and the ATR1 promoter region contains a binding site for the GCN4 activator protein.; Phenotype: multiple copies of ATR1 permit growth at extremely high concentrations of aminotriazole (80 mM),whereas a chromosomal deletion of ATR1 causes growth inhibition at very low concentrations (5 mM).; Similarity: ATR1 is a member of the multidrug-resistance 14-spanner (DHA14) family of the major facilitator superfamily (MFS-MDR).; Title: strong similarity to aminotriazole resistance protein Atr1 - Saccharomyces cerevisiae; plasma membrane; See PMID 3280970; uncharacterized protein 2083343 4983189 An08g08710 Aspergillus niger uncharacterized protein XP_001392983.1 2081802 D 5061 CDS An08g08720 4983190 join(2084366..2084475,2084536..2085367) VIII 1 NT_166524.1 Catalytic activity: 2 ferrocytochrome c + H(2)O(2) = 2 ferricytochrome c + 2 H(2)O.; Function: CCP1 is involved in conveying an oxidative stress signal to the transcription factor Pos9 (Skn7).; Function: the mitochondrial cytochrome c peroxidase CCP1 degrades reactive oxygen species within the mitochondria.; Title: strong similarity to cytochrome-c peroxidase precursor Ccp1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 6286684; See PMID 10589830; uncharacterized protein 2085367 4983190 An08g08720 Aspergillus niger uncharacterized protein XP_001392984.3 2084366 D 5061 CDS An08g08730 4983191 complement(2086186..2089026) VIII 1 NT_166524.1 Remark: similarity is based on glutamine- and alanine-rich repeat region.; Title: weak similarity to transcription factor CA150 - Homo sapiens; uncharacterized protein 2089026 4983191 An08g08730 Aspergillus niger uncharacterized protein XP_001392985.3 2086186 R 5061 CDS An08g08740 4983192 join(2089828..2089831,2090085..2090250,2090416..2090713) VIII 1 NT_166524.1 Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S18 - Homo sapiens; cytoplasm; See PMID 8441687; See PMID 8706699; 40S ribosomal protein uS13 2090713 4983192 An08g08740 Aspergillus niger 40S ribosomal protein uS13 XP_001392986.1 2089828 D 5061 CDS An08g08750 4983193 complement(join(2091333..2092498,2092561..2093068)) VIII 1 NT_166524.1 Gene-ID: cpy; Mapping: cpy from A. niger is mapped to chromosome IV; see list from DSM.; Remark: a splice site was detected upstream of the START codon.; carboxypeptidase Y cpy from patent WO9609397-A1-Aspergillus niger 2093068 cpy 4983193 cpy Aspergillus niger carboxypeptidase Y cpy from patent WO9609397-A1-Aspergillus niger XP_001392987.1 2091333 R 5061 CDS An08g08760 4983194 join(2093680..2093746,2093908..2094286,2094347..2094868,2094931..2094955) VIII 1 NT_166524.1 Title: similarity to colon cancer associated antigen precursor from patent WO9904265-A2 - Homo sapiens; uncharacterized protein 2094955 4983194 An08g08760 Aspergillus niger uncharacterized protein XP_059606169.1 2093680 D 5061 CDS An08g08770 4983195 complement(join(2095105..2095130,2095257..2095443,2095486..2095799,2095849..2096195,2096278..2096501)) VIII 1 NT_166524.1 Function: reversible phosphorylation plays an important role in pre-mRNA splicing in mammalian cells. three kinases, SR protein-specific kinase (SRPK1 & 2) and Clk/Sty, have been shown to phosphorylate the SR family of splicing factors.; Remark: the ORF shows similarity to various protein kinases, not all are implicated in splicing factor phosphorylation.; Similarity: the predicted protein seems approximately only the half of the length of the blast homologs.; Title: similarity to serine kinase SRPK2 - Homo sapiens; See PMID 9472028; uncharacterized protein 2096501 4983195 An08g08770 Aspergillus niger uncharacterized protein XP_059606170.1 2095105 R 5061 CDS An08g08780 4983196 complement(join(2098922..2099208,2099314..2099650)) VIII 1 NT_166524.1 hypothetical protein 2099650 4983196 An08g08780 Aspergillus niger hypothetical protein XP_001392990.1 2098922 R 5061 CDS An08g08790 84591774 complement(join(2100184..2100258,2100349..2100516,2100757..2101016,2101113..2101216,2101354..2101458,2101505..2101572,2101672..2101729,2101816..2101905,2102113..2102164,2102249..2102345)) VIII 1 NT_166524.1 Remark: in Intron 2 there is a predicted Arg tRNA.; hypothetical protein 2102345 84591774 An08g08790 Aspergillus niger hypothetical protein XP_059606171.1 2100184 R 5061 CDS An08g08810 84591775 complement(join(2102549..2102864,2102991..2103244)) VIII 1 NT_166524.1 hypothetical protein 2103244 84591775 An08g08810 Aspergillus niger hypothetical protein XP_059606172.1 2102549 R 5061 CDS An08g08820 4983200 join(2103963..2104057,2104155..2104594,2104663..2105858) VIII 1 NT_166524.1 Remark: a splice site was detected upstream of the START codon.; Title: similarity to hypothetical protein ZK84.1 -Caenorhabditis elegans; uncharacterized protein 2105858 4983200 An08g08820 Aspergillus niger uncharacterized protein XP_001392993.1 2103963 D 5061 CDS An08g08830 84591776 complement(join(2106638..2106741,2106798..2107210,2107274..2107443,2107490..2107531)) VIII 1 NT_166524.1 Title: weak similarity to hypothetical L-lactate dehydrogenase mll6909 - Mesorhizobium loti; uncharacterized protein 2107531 84591776 An08g08830 Aspergillus niger uncharacterized protein XP_059606173.1 2106638 R 5061 CDS An08g08840 4983202 join(2107588..2107823,2107873..2107900,2107949..2109117,2109176..2109290) VIII 1 NT_166524.1 Catalytic activity: L-glutamate = 4-aminobutanoate + CO2.; Function: catalyzes the production of GABA. the calmodulin-binding is calcium-dependent and it is proposed that this may, directly or indirectly, form a calcium regulated control of GABA biosynthesis.; Pathway: Glutamate metabolism; alanine and aspartate metabolism; beta-alanine metabolism; taurine and hypotaurine metabolism; butanoate metabolism.; Remark: the enzymatic activities of the pure recombinant GAD1 and GAD2 proteins were stimulated 35- and 13-fold, respectively, by Ca2+/calmodulin but not by Ca2+ or calmodulin alone. GAD1 transcript and a corresponding 58-kD peptide were detected in roots only.; Similarity: belongs to the glutamate decarboxylase and related PLP-dependent proteins.; Title: strong similarity to glutamate decarboxylase GAD1 - Arabidopsis thaliana; See PMID 7610159; See PMID 9701597; See PMID 11021657; uncharacterized protein 2109290 4983202 An08g08840 Aspergillus niger uncharacterized protein XP_001392995.1 2107588 D 5061 CDS An08g08850 4983203 join(2109391..2109419,2109826..2111210,2111261..2112288) VIII 1 NT_166524.1 Title: weak similarity to vegetative cell wall protein GP1 - Chlamydomonas reinhardtii; uncharacterized protein 2112288 4983203 An08g08850 Aspergillus niger uncharacterized protein XP_059606174.1 2109391 D 5061 CDS An08g08860 4983204 complement(join(2112599..2113283,2113341..2114368)) VIII 1 NT_166524.1 Title: weak similarity to period protein per -Drosophila sucinea; uncharacterized protein 2114368 4983204 An08g08860 Aspergillus niger uncharacterized protein XP_059606175.1 2112599 R 5061 CDS An08g08870 4983205 complement(join(2114717..2114946,2114999..2115506)) VIII 1 NT_166524.1 Remark: nrgA exhibited amino acid sequence similarity to bacterial hydroxylases and N-acetyltransferases. Null mutations introduced into nrgA and nrgBC resulted in mutant strains that exhibited wild-type-like symbiotic properties, including nitrogen fixation, when tested on soybean, cowpea, or mung bean host plants.; Similarity: to bacterial hydroxylases and N-acetyltransferases.; Title: similarity to NifA-regulated gene A NrgA -Bradyrhizobium japonicum; See PMID 10692350; uncharacterized protein 2115506 4983205 An08g08870 Aspergillus niger uncharacterized protein XP_001392998.1 2114717 R 5061 CDS An08g08880 84591777 complement(join(2116016..2116293,2116337..2116418)) VIII 1 NT_166524.1 hypothetical protein 2116418 84591777 An08g08880 Aspergillus niger hypothetical protein XP_059606176.1 2116016 R 5061 CDS An08g08890 4983207 2116705..2118129 VIII 1 NT_166524.1 Title: similarity to hypothetical protein Rv1619 -Mycobacterium tuberculosis; uncharacterized protein 2118129 4983207 An08g08890 Aspergillus niger uncharacterized protein XP_001393000.1 2116705 D 5061 CDS An08g08900 84591778 complement(join(2118907..2119344,2119433..2119574,2119655..2119974)) VIII 1 NT_166524.1 Title: weak similarity to farnesyl diphosphate synthase IspA from patent WO200056915-A1 - Streptococcus pneumoniae; uncharacterized protein 2119974 84591778 An08g08900 Aspergillus niger uncharacterized protein XP_059606177.1 2118907 R 5061 CDS An08g08910 4983209 complement(join(2121677..2123153,2123234..2123457)) VIII 1 NT_166524.1 Catalytic activity: sulfite + O2 + H2O = sulfate + H2O2.; Pathway: sulfur metabolism. Terminal reaction in the oxidative degradation of sulfur- containing amino acids. it uses cytochrome c as an electron acceptor.; Remark: the molybdenum-containing human enzyme sulfite oxidase catalyzes the conversion of sulfite to sulfate, the terminal step in the oxidative degradation of cysteine and methionine. Genetic deficiency of sulfite oxidase results in neurological abnormalities and often leads to death at an early age.; Similarity: with cytochrome B5 and nitrate reductase.; Title: strong similarity to mitochondrial sulfite oxidase SUOX - Homo sapiens; See PMID 7599189; See PMID 9428520; See PMID 9600976; uncharacterized protein 2123457 4983209 An08g08910 Aspergillus niger uncharacterized protein XP_001393002.3 2121677 R 5061 CDS An08g08920 4983210 complement(join(2124326..2124349,2124466..2124631,2124809..2124972,2125018..2125283,2125332..2125416,2125477..2125764,2125812..2125939,2125982..2125989,2126025..2126137,2126197..2126407,2126461..2126484,2126547..2126673,2126723..2126753)) VIII 1 NT_166524.1 Catalytic activity: 2 H2O2 = O2 + 2 H2O.; Pathway: tryptophan metabolism; methane metabolism.; Remark: with a molecular mass of 54 kDa, CatC shows high similarity to other small-subunit monofunctional catalases and is most closely related to catalases from other fungi, Archaea, and animals. The catC gene displayed a relatively constant pattern of expression, not being induced by oxidative or other types of stress.; Similarity: belongs to the catalase family.; Title: strong similarity to catalase C catC -Aspergillus nidulans; See PMID 11157957; uncharacterized protein 2126753 4983210 An08g08920 Aspergillus niger uncharacterized protein XP_059606178.1 2124326 R 5061 CDS An08g08930 4983211 complement(2126982..2127557) VIII 1 NT_166524.1 Title: similarity to hypothetical protein CAE41807.1 - Bordetella pertussis; uncharacterized protein 2127557 4983211 An08g08930 Aspergillus niger uncharacterized protein XP_001393004.1 2126982 R 5061 CDS An08g08940 4983212 complement(join(2127847..2128683,2128765..2129172)) VIII 1 NT_166524.1 Catalytic activity: a nitrile + H2O = a carboxylate + NH3.; Pathway: tryptophan metabolism; cyanoamino acid metabolism; nitrogen metabolism.; Remark: nitrilases (nitrile aminohydrolase, EC 3. 5. 5. 1) convert nitriles to carboxylic acids. The nitrilase genes encode very similar proteins that hydrolyze indole-3-acetonitrile to the phytohormone indole-3-acetic acid in vitro.; Similarity: belongs to the nitrilases.; Title: strong similarity to nitrilase NIT3 -Arabidopsis thaliana; See PMID 8022831; See PMID 9484465; uncharacterized protein 2129172 4983212 An08g08940 Aspergillus niger uncharacterized protein XP_001393005.1 2127847 R 5061 CDS An08g08950 4983213 complement(join(2129528..2129815,2130008..2130868,2130929..2131339)) VIII 1 NT_166524.1 Catalytic activity: choline sulfate + H2O = choline + sulfate.; Remark: a mutant deficient in choline dehydrogenase (CDH) activity, failed to oxidize [methyl-14C]choline to [methyl-14C]betaine, and did not use choline, but still used betaine, as an osmoprotectant.; Similarity: belongs to the animal sulfatase family.; Title: strong similarity to choline sulfatase betC -Sinorhizobium meliloti; See PMID 9141699; uncharacterized protein 2131339 4983213 An08g08950 Aspergillus niger uncharacterized protein XP_059606179.1 2129528 R 5061 CDS An08g08960 84591779 join(2131661..2131874,2132114..2132276,2132505..2132682) VIII 1 NT_166524.1 Title: weak similarity to protein fragment SEQ ID NO:56682 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 2132682 84591779 An08g08960 Aspergillus niger uncharacterized protein XP_059606180.1 2131661 D 5061 CDS An08g08970 84591780 complement(join(2133955..2133979,2134027..2134124)) VIII 1 NT_166524.1 hypothetical protein 2134124 84591780 An08g08970 Aspergillus niger hypothetical protein XP_059606181.1 2133955 R 5061 CDS An08g08980 4983216 complement(join(2134577..2134595,2134643..2135316,2135363..2135688,2135782..2136702,2136770..2136854)) VIII 1 NT_166524.1 Remark: the patent represents a novel polypeptide with hematopoietic cell regulatory activity and tissue forming/repairing activity.; Similarity: strong similarity to human putative SST-homologue patent WO200008056-A1 found in PATENTPROT:AAY80519.; Similarity: the ORF also shows strong similarity to some endosomal proteins with unknown function, like EMP70 of S. cerevisiae.; Title: strong similarity to protein from patent WO200008056-A1 - Homo sapiens; uncharacterized protein 2136854 4983216 An08g08980 Aspergillus niger uncharacterized protein XP_059606182.1 2134577 R 5061 CDS An08g08990 84591781 join(2136970..2137027,2137076..2137201,2137310..2137596) VIII 1 NT_166524.1 hypothetical protein 2137596 84591781 An08g08990 Aspergillus niger hypothetical protein XP_059606183.1 2136970 D 5061 CDS An08g09000 4983218 complement(join(2138378..2138543,2138859..2139313,2139389..2139853)) VIII 1 NT_166524.1 Remark: Dsk2p is a nuclear-enriched protein, and that Dsk2p assists in Cdc31 assembly into the new pindle pole body (SPB).; Title: strong similarity to ubiquitin like protein Dsk2 - Saccharomyces cerevisiae; See PMID 8682868; uncharacterized protein 2139853 4983218 An08g09000 Aspergillus niger uncharacterized protein XP_059606184.1 2138378 R 5061 CDS An08g09010 4983219 join(2140661..2140904,2141078..2143151,2143345..2144629,2144680..2144706) VIII 1 NT_166524.1 Remark: SAPs 49, 130, 145, and 155 are components of U2 snRNP-associated protein complex essential for spliceosome assembly named SF3b.; Remark: also strong similarity to Human secreted protein clone pm412_12 protein sequence SEQ ID NO:46 patent WO200009552-A1.; Title: strong similarity to spliceosomal protein SAP130 - Homo sapiens; See PMID 10490618; uncharacterized protein 2144706 4983219 An08g09010 Aspergillus niger uncharacterized protein XP_001393012.1 2140661 D 5061 CDS An08g09020 4983220 complement(join(2145561..2145676,2145750..2145837,2145932..2146801,2146848..2147123,2147176..2147481)) VIII 1 NT_166524.1 Gene-ID: gmdB; Remark: the enzyme acts probably on carbon-nitrogen bonds, other than peptide bonds In linear amides.; Similarity: belongs to the amidotransferase A subunit and related amidases.; general amidase gmdB-Aspergillus niger 2147481 gmdB 4983220 gmdB Aspergillus niger general amidase gmdB-Aspergillus niger XP_001393013.1 2145561 R 5061 CDS An08g09030 4983221 complement(join(2148153..2148254,2148315..2148920,2148976..2149035,2149104..2149475,2149534..2149734)) VIII 1 NT_166524.1 Catalytic activity: random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins.; Pathway: aminosugars metabolism.; Remark: Chitinase has been suggested to play a pivotal role in autolysis of the parasitic cell wall of Coccidioides immitis during the asexual reproductive cycle (endosporulation) of this systemic pathogen. Loss of CTS1 function had no effect on virulence or endosporulation. The absence of a functional CTS1 gene can be compensated for by elevated expression of the CTS2 gene.; Similarity: belongs to the Streptomyces chitinase chi40 family.; Title: strong similarity to chitinase 1 cts1 -Coccidioides immitis; See PMID 8566773; See PMID 10992492; uncharacterized protein 2149734 4983221 An08g09030 Aspergillus niger uncharacterized protein XP_001393014.3 2148153 R 5061 CDS An08g09040 4983222 complement(join(2151182..2152512,2152576..2152780)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein YNR069c -Saccharomyces cerevisiae; uncharacterized protein 2152780 4983222 An08g09040 Aspergillus niger uncharacterized protein XP_001393015.1 2151182 R 5061 CDS An08g09050 84591782 join(2152916..2152945,2153056..2153196,2153224..2153333,2153420..2153612,2153698..2153793,2153921..2154018,2154132..2154228,2154284..2154679,2154791..2154886) VIII 1 NT_166524.1 hypothetical protein 2154886 84591782 An08g09050 Aspergillus niger hypothetical protein XP_059606185.1 2152916 D 5061 CDS An08g09060 84591783 join(2155468..2155541,2155572..2155593) VIII 1 NT_166524.1 hypothetical protein 2155593 84591783 An08g09060 Aspergillus niger hypothetical protein XP_059606186.1 2155468 D 5061 CDS An08g09070 84591784 2156318..2156563 VIII 1 NT_166524.1 Remark: partial cds.; hypothetical protein 2156563 84591784 An08g09070 Aspergillus niger hypothetical protein XP_059606187.1 2156318 D 5061 CDS An08g09080 84591785 join(2156706..2156886,2156944..2157277,2157361..2157445,2157799..2157873) VIII 1 NT_166524.1 Similarity: N-terminal half show similarity to putative aminoacyl-transfer RNA synthetase PA4724 of P. aeruginosa.; Title: weak similarity to hypothetical aminoacyl-transfer RNA synthase PA4724 - Pseudomonas aeruginosa; uncharacterized protein 2157873 84591785 An08g09080 Aspergillus niger uncharacterized protein XP_059606188.1 2156706 D 5061 CDS An08g09090 84591786 complement(join(2158799..2159825,2159884..2160161)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein B11E5.130 - Neurospora crassa; uncharacterized protein 2160161 84591786 An08g09090 Aspergillus niger uncharacterized protein XP_059606189.1 2158799 R 5061 CDS An08g09100 4983228 join(2160899..2160988,2161068..2161526,2161738..2161926) VIII 1 NT_166524.1 Title: weak similarity to hypothetical protein F9F8.20 - Arabidopsis thaliana; uncharacterized protein 2161926 4983228 An08g09100 Aspergillus niger uncharacterized protein XP_001393021.3 2160899 D 5061 CDS An08g09110 84591787 complement(2162281..2162805) VIII 1 NT_166524.1 Title: similarity to hypothetical UDP-glucose,sterol transferase gstA - Aspergillus oryzae; uncharacterized protein 2162805 84591787 An08g09110 Aspergillus niger uncharacterized protein XP_059606190.1 2162281 R 5061 CDS An08g09120 4983230 complement(join(2163236..2163590,2163649..2164015,2164079..2164236,2164301..2165042,2165121..2165289)) VIII 1 NT_166524.1 Catalytic activity: UDP-glucose + a sterol <=> UDP + an O-glucosylsterol.; Remark: C-terminal conserved region is sufficient and essential for enzyme activity, N-terminal residues are not required for in vitro glucosyltransferase activity.; Remark: similarity only to C-terminal region of C. albicans UDP-glucose:sterol glucosyltransferase.; Title: similarity to UDP-glucose:sterol glucosyltransferase UGT51C1 - Candida albicans; uncharacterized protein 2165289 4983230 An08g09120 Aspergillus niger uncharacterized protein XP_001393023.3 2163236 R 5061 CDS An08g09130 84591788 join(2165484..2165595,2165635..2165691,2165799..2165878,2165929..2166126) VIII 1 NT_166524.1 hypothetical protein 2166126 84591788 An08g09130 Aspergillus niger hypothetical protein XP_059606191.1 2165484 D 5061 CDS An08g09140 4983232 join(2166467..2166772,2166826..2168973) VIII 1 NT_166524.1 Catalytic activity: Hydrolysis of terminal,non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.; Function: RhaA from A. aculeatus is able to hydrolyze alpha-1,2 and alpha-1,6 linkages to beta-D-glucosides.; Title: strong similarity to alpha-L-rhamnosidase A precursor rhaA - Aspergillus aculeatus; See PMID 11319105; uncharacterized protein 2168973 4983232 An08g09140 Aspergillus niger uncharacterized protein XP_001393025.1 2166467 D 5061 CDS An08g09150 4983233 complement(join(2170068..2170362,2170440..2170810)) VIII 1 NT_166524.1 Catalytic activity: RX + glutathione <=> HX + R-S-glutathione.; Title: strong similarity to hypothetical glutathione S-transferase SPCC965.07c - Schizosaccharomyces pombe; See PMID 10720752; uncharacterized protein 2170810 4983233 An08g09150 Aspergillus niger uncharacterized protein XP_001393026.1 2170068 R 5061 CDS An08g09160 4983234 complement(join(2171400..2171842,2171896..2172040,2172091..2173488,2173545..2176584,2176638..2177014)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical membrane protein YJL109c - Saccharomyces cerevisiae; uncharacterized protein 2177014 4983234 An08g09160 Aspergillus niger uncharacterized protein XP_001393027.1 2171400 R 5061 CDS An08g09170 4983235 join(2177291..2177315,2177422..2179787,2179927..2180880) VIII 1 NT_166524.1 Title: similarity to hypothetical protein SPBC20F10.05 - Schizosaccharomyces pombe; uncharacterized protein 2180880 4983235 An08g09170 Aspergillus niger uncharacterized protein XP_059606192.1 2177291 D 5061 CDS An08g09180 4983236 complement(2181337..2182128) VIII 1 NT_166524.1 Function: esterase activity against short-chain alkyl esters of 4-nitrophenol but was also able to hydrolyze ethyl salicylate to ethanol and salicylic acid.; Title: similarity to alkyl salicylate esterase salE - Acinetobacter sp.; See PMID 10715011; uncharacterized protein 2182128 4983236 An08g09180 Aspergillus niger uncharacterized protein XP_001393029.1 2181337 R 5061 CDS An08g09190 4983237 complement(join(2183380..2184531,2184592..2184950,2185014..2185392)) VIII 1 NT_166524.1 Remark: a FAD containing protein.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Remark: moxY of A. parasiticus is expressed concurrently with genes involved in aflatoxin biosynthesis and it lies on one end of the cluster of this genes. Therefore moxY of A. parasiticus is presumably also involved in aflatoxin biosynthesis.; Title: strong similarity to hypothetical monooxygenase moxY - Aspergillus parasiticus; See PMID 10855719; uncharacterized protein 2185392 4983237 An08g09190 Aspergillus niger uncharacterized protein XP_059606193.1 2183380 R 5061 CDS An08g09200 84591789 complement(join(<2186387..2186439,2186541..>2186690)) VIII 1 NT_166524.1 hypothetical protein 2186690 84591789 An08g09200 Aspergillus niger hypothetical protein XP_059606194.1 2186387 R 5061 CDS An08g09210 4983239 2186768..2187838 VIII 1 NT_166524.1 Catalytic activity: E. coli QueA catalyzes the synthesis of an epoxycyclopentane moiety and transfers this compound to specific tRNAs containing the queuosine precursor 7-(aminomethyl)-7-deazaguanine (preQ1).; Function: E. coli QueA catalyzes the penultimate step in the biosynthesis of the tRNA wobble nucleoside queuosine, a unique ribosyl transfer from the cofactor S-adenosylmethionine (AdoMet) to a modified-tRNA precursor.; Title: strong similarity to S-adenosylmethionine tRNA ribosyltransferase queA - Bacillus subtilis; See PMID 8347586; See PMID 10739928; See PMID 10810734; uncharacterized protein 2187838 4983239 An08g09210 Aspergillus niger uncharacterized protein XP_001393032.1 2186768 D 5061 CDS An08g09220 84591790 complement(join(2188106..2188570,2188681..2189778)) VIII 1 NT_166524.1 Function: NosA from Nostoc sp. is involved in activation of L-tyrosine and L-proline.; Similarity: the predicted A. niger protein shows similarity to several polyketide synthase genes.; Title: similarity to multifunctional peptide synthetase of the nostopeptolide biosynthetis NosD - Nostoc sp.; uncharacterized protein 2189778 84591790 An08g09220 Aspergillus niger uncharacterized protein XP_059606195.1 2188106 R 5061 CDS An08g09230 4983241 complement(join(2190079..2190426,2190508..2191617,2191687..2191731)) VIII 1 NT_166524.1 Catalytic activity: TRI11 of F. sporotrichioides catalyzes the hydroxylation at C-15 of isotrichodermin.; Function: TRI11 of F. sporotrichioides encodes a C-15 hydroxylase involved in trichothecene biosynthesis.; Pathway: TRI11 of F. sporotrichioides is a component of the trichothecene biosynthetic pathway.; Phenotype: disruption of TRI11 of F. sporotrichioides results in an altered trichothecene production phenotype characterized by the accumulation of isotrichodermin, a trichothecene pathway intermediate.; Remark: TRI11 of F. sporotrichioides belongs to the cytochrome P450 superfamily.; Remark: trichothecenes are sesquiterpendoid toxins,which inhibit protein biosynthesis.; Similarity: the ORF shows similarity to cytochrome P450 of many different species.; Title: strong similarity to isotrichodermin C-15 hydroxylase Tri11 - Fusarium sporotrichioides; See PMID 9435078; uncharacterized protein 2191731 4983241 An08g09230 Aspergillus niger uncharacterized protein XP_059606196.1 2190079 R 5061 CDS An08g09240 4983242 join(2193322..2193361,2193615..2194126,2194219..2194752,2194816..2195311,2195437..2195486,2195750..2196169) VIII 1 NT_166524.1 Similarity: the homology between the ORF and the hypothetical S. pombe protein extends over a large N-terminal region spanning about 400 amino acids.; Title: similarity to hypothetical transcription regulator SPAC139.03 - Schizosaccharomyces pombe; uncharacterized protein 2196169 4983242 An08g09240 Aspergillus niger uncharacterized protein XP_059606197.1 2193322 D 5061 CDS An08g09250 4983243 join(2196668..2196790,2196839..2196935,2197002..2197951,2198027..2198329) VIII 1 NT_166524.1 Remark: YBR180w is the systematic name for S. cerevisiae DTR1.; Remark: information regarding S. cerevisiae DTR1 has not yet been published and is available via http://genome-www. stanford. edu/cgi-bin/SGD/genehunter.; Similarity: S. cerevisiae DTR1 belongs to the major facilitator family of transport proteins.; Title: similarity to dityrosine transporter Dtr1 -Saccharomyces cerevisiae; uncharacterized protein 2198329 4983243 An08g09250 Aspergillus niger uncharacterized protein XP_059606198.1 2196668 D 5061 CDS An08g09260 4983244 complement(join(2198825..2198890,2199001..2199135,2199204..2199544,2199636..2200090,2200151..2201166,2201233..2201343)) VIII 1 NT_166524.1 Catalytic activity: acetoacetyl-CoA synthetases catalyse the reaction, ATP + Acetoacetate + CoA = AMP + Pyrophosphate + Acetoacetyl-CoA.; Function: acetoacetyl-CoA synthetases are involved in multiple biochemical pathways.; Title: strong similarity to acetoacetyl-CoA synthase acsA - Sinorhizobium meliloti; uncharacterized protein 2201343 4983244 An08g09260 Aspergillus niger uncharacterized protein XP_001393037.3 2198825 R 5061 CDS An08g09270 84591791 join(2201466..2201535,2201589..2201638,2201770..2201859,2201935..2202006,2202095..2202148,2202226..2202279,2202381..2202648,2202776..2202820,2202901..2203073) VIII 1 NT_166524.1 hypothetical protein 2203073 84591791 An08g09270 Aspergillus niger hypothetical protein XP_059606199.1 2201466 D 5061 CDS An08g09280 4983246 join(2203139..2203297,2203358..2203435,2203496..2204039,2204078..2204105,2204224..2204491) VIII 1 NT_166524.1 Function: E. coli hpaG is a bifunctional decarboxylase/isomerase.; Function: E. coli hpaG is required for the utilisation of 3,4-hydroxy-phenylacetate.; Remark: the ORF is shorter than hpaG of E. coli (358 compared to 429 amino acids) and the two proteins show homology only over a N-terminal stretch of about 200 amino acids.; Title: similarity to 5-oxo-1,2,5-tricarboxilic-3-penten acid decarboxilase/isomer hpaG -Escherichia coli; See PMID 8550403; uncharacterized protein 2204491 4983246 An08g09280 Aspergillus niger uncharacterized protein XP_001393039.3 2203139 D 5061 CDS An08g09290 84591792 complement(join(2205094..2205956,2206034..2206124)) VIII 1 NT_166524.1 Similarity: the predicted A. niger protein contains a central polysaccharide deacetylase domain.; Title: similarity to cellular protein hp5p15641_5211687_c2_29 from patent WO9737044-A1 -Helicobacter pylori; uncharacterized protein 2206124 84591792 An08g09290 Aspergillus niger uncharacterized protein XP_059606200.1 2205094 R 5061 CDS An08g09300 84591793 join(2206349..2206862,2206899..2207005) VIII 1 NT_166524.1 Title: similarity to prokaryotic essential protein #7529 from patent WO200277183-A2 - Burkholderia fungorum; uncharacterized protein 2207005 84591793 An08g09300 Aspergillus niger uncharacterized protein XP_059606201.1 2206349 D 5061 CDS An08g09310 4983249 join(2207860..2207991,2208211..2208348,2208418..2208748,2208837..2209076,2209231..2210140,2210209..2210624,2210713..2210978) VIII 1 NT_166524.1 Function: in A. nidulans amdA induces expression of the acetamidase, amdS.; Similarity: A. nidulans amdA contains two C2H2 zinc-finger motifs.; Title: strong similarity to zinc-finger transcription factor amdA - Aspergillus nidulans; nucleus; uncharacterized protein 2210978 4983249 An08g09310 Aspergillus niger uncharacterized protein XP_059606202.1 2207860 D 5061 CDS An08g09320 4983250 complement(join(2211045..2212245,2212312..2212664)) VIII 1 NT_166524.1 Function: S. cerevisiae Flr1 is a transmembrane transporter confering fluconazole resistance.; Induction: S. cerevisiae Flr1 is transcriptionally regulated by the Cap1 and yAP-1 proteins.; Remark: YBR008c is the systematic name for S. cerevisiae Flr1.; Similarity: S. cerevisiae Flr1 belongs to the major facilitator family (TC 2. A. 1).; Title: strong similarity to fluconazole resistance transporter Flr1 - Saccharomyces cerevisiae; plasma membrane; See PMID 9235926; uncharacterized protein 2212664 4983250 An08g09320 Aspergillus niger uncharacterized protein XP_001393043.1 2211045 R 5061 CDS An08g09330 4983251 2213932..2215041 VIII 1 NT_166524.1 Catalytic activity: 8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-enyl}cyclopentyl]octanoate + NADP(+) <=> (15Z)-12-oxophyto-10,15-dienoate + NADPH.; Function: opr of L. esculentum is a flavin mononucleotide (FMN)-dependent oxidoreductase in plants that belongs to the family of Old Yellow Enzyme (OYE).; Pathway: opr of L. esculentum is involved in the biosynthesis of the plant hormone jasmonic acid.; Title: strong similarity to 12-oxophytodienoate reductase opr - Lycopersicon esculentum; See PMID 11377202; uncharacterized protein 2215041 4983251 An08g09330 Aspergillus niger uncharacterized protein XP_001393044.1 2213932 D 5061 CDS An08g09340 4983252 complement(join(2216873..2217160,2217222..2217476,2217538..2217807)) VIII 1 NT_166524.1 Function: SOU1 is required for L-sorbose assimilation in Candida albicans.; Remark: C. albicans SOU1 belongs to the short-chain dehydrogenase/reductases family (SDR).; Title: strong similarity to short-chain dehydrogenase sou1 - Candida albicans; uncharacterized protein 2217807 4983252 An08g09340 Aspergillus niger uncharacterized protein XP_001393045.1 2216873 R 5061 CDS An08g09350 4983253 join(2218327..2218471,2218532..2219048,2219093..2219324,2219381..2220031) VIII 1 NT_166524.1 Title: strong similarity to hexose transporter hxtA - Aspergillus parasiticus; plasma membrane; See PMID 10978525; uncharacterized protein 2220031 4983253 An08g09350 Aspergillus niger uncharacterized protein XP_059606203.1 2218327 D 5061 CDS An08g09360 4983254 join(2220709..2221266,2221321..2221518,2221573..2221656) VIII 1 NT_166524.1 Function: SOU2 is required for L-sorbose assimilation in Candida albicans.; Similarity: C. albicans SOU2 belongs to the short-chain dehydrogenase/reductases family (SDR).; Title: strong similarity to sorbitol utilization protein sou2 - Candida albicans; uncharacterized protein 2221656 4983254 An08g09360 Aspergillus niger uncharacterized protein XP_059606204.1 2220709 D 5061 CDS An08g09370 4983255 complement(join(2221875..2222349,2222431..2222663,2222714..2222839,2222993..2223393,2223447..2223980,2224054..2224357,2224408..2224478,2224665..2224743)) VIII 1 NT_166524.1 Function: S. cerevisiae Gal4 is a positive regulator of the galactose-inducible genes.; Similarity: S. cerevisiae Gal4 belongs to the family of fungal Zn(II)2Cys6 binuclear cluster DNA binding domain containing transcription factors.; Title: similarity to transcription factor Gal4 -Saccharomyces cerevisiae; nucleus; See PMID 6366516; See PMID 7601342; uncharacterized protein 2224743 4983255 An08g09370 Aspergillus niger uncharacterized protein XP_059606205.1 2221875 R 5061 CDS An08g09380 4983256 complement(join(2225196..2225432,2225482..2226022,2226099..2226228,2226292..2226451,2226627..2226722)) VIII 1 NT_166524.1 Catalytic activity: xylitol dehydrogenases catalyzes the oxidation by NAD+ of xylitol to D-xylulose.; Function: xdh from G. mastotermitis catalyses the second step in the xylose utilising pathway converting xylose to xylulosephosphate.; Similarity: xdh from G. mastotermitis belongs to the superfamily of zinc containing, medium-chain alcohol dehydrogenases.; Title: strong similarity to xylitol dehydrogenase xdh - Galactocandida mastotermitis; See PMID 10661867; uncharacterized protein 2226722 4983256 An08g09380 Aspergillus niger uncharacterized protein XP_059606206.1 2225196 R 5061 CDS An08g09390 4983257 join(2227562..2227612,2227760..2228105,2228154..2228482) VIII 1 NT_166524.1 Remark: frcK of S. meliloti is part of the ATP binding cassette fructose transporter operon.; Remark: the ORF shows also similarity to other hypothetical kinases.; Remark: the frc system is also a high-affinity transporter for ribose and mannose, which are both fructose competitors for the binding to the periplasmic FrcB protein.; Title: similarity to hypothetical kinase frcK -Sinorhizobium meliloti; See PMID 11466273; uncharacterized protein 2228482 4983257 An08g09390 Aspergillus niger uncharacterized protein XP_059606207.1 2227562 D 5061 CDS An08g09400 84591794 complement(join(2230248..2230306,2230414..2230683,2231009..2231090)) VIII 1 NT_166524.1 Title: weak similarity to hypothetical protein TP0491 - Treponema pallidum; uncharacterized protein 2231090 84591794 An08g09400 Aspergillus niger uncharacterized protein XP_059606208.1 2230248 R 5061 CDS An08g09410 84591795 join(2231569..2231823,2231878..2232103,2232208..2232526,2232619..2232756,2233491..2234162,2234380..2234512,2234609..2234740,2235004..2235192) VIII 1 NT_166524.1 Function: in S. cerevisiae overexpression of RTM1 confers resistance to the toxicity of molasses.; Remark: RTM loci are always physically associated with SUC telomeric loci.; Title: similarity to molasses resistency protein Rtm1 - Saccharomyces cerevisiae; uncharacterized protein 2235192 84591795 An08g09410 Aspergillus niger uncharacterized protein XP_059606209.1 2231569 D 5061 CDS An08g09420 4983260 2235634..2236206 VIII 1 NT_166524.1 Remark: information regarding M. anisopliae 4MeS has not yet been published.; Title: strong similarity to protein 4MeS -Metarhizium anisopliae; uncharacterized protein 2236206 4983260 An08g09420 Aspergillus niger uncharacterized protein XP_001393053.1 2235634 D 5061 CDS An08g09430 4983261 complement(2237457..2239775) VIII 1 NT_166524.1 Similarity: the N-terminus of the predicted A. niger protein contains a predicted transmembrane and a phoshorylase domain.; Similarity: the predicted A. niger protein contains several WD-40 repeats in its C-terminal half and shows similarity to multiple WD-40 containing proteins.; Title: similarity to notchless Nle - Drosophila melanogaster; See PMID 9857191; uncharacterized protein 2239775 4983261 An08g09430 Aspergillus niger uncharacterized protein XP_059606210.1 2237457 R 5061 CDS An08g09440 84591796 join(2240375..2240427,2240999..2241048,2241172..2241665) VIII 1 NT_166524.1 Catalytic activity: ATP + L-asparagine + tRNA(asn) = AMP + pyrophosphate + L-asparaginyl-tRNA(asn).; Remark: asparagine-tRNA ligases are also called asparaginyl-tRNA synthetases or asparagine translases.; Remark: the gene coding for NRSEC of E. coli is called asnS or tss.; Similarity: the ORF is much shorter than NRSEC of E. coli (198 compared to 466 amino acids).; Similarity: the ORF shows similarity to asparagyl-tRNA synthetases of various species.; Title: similarity to asparagine-tRNA ligase NRSEC -Escherichia coli; cytoplasm; See PMID 1425658; See PMID 2009959; See PMID 2693216; uncharacterized protein 2241665 84591796 An08g09440 Aspergillus niger uncharacterized protein XP_059606211.1 2240375 D 5061 CDS An08g09450 4983263 complement(join(2243123..2243289,2243351..2243986,2244047..2244131)) VIII 1 NT_166524.1 Function: 3-hydroxyacyl-CoA dehydrogenase is an enzyme involved in fatty acid metabolism, it catalyzes the reduction of 3-hydroxyacyl-CoA to 3-oxoacyl-CoA.; Similarity: the ORF is shorter than hbd of C. acetobutylicum.; Title: similarity to 3-hydroxybutyryl-CoA dehydrogenase hbd - Clostridium acetobutylicum; See PMID 8655474; uncharacterized protein 2244131 4983263 An08g09450 Aspergillus niger uncharacterized protein XP_001393056.1 2243123 R 5061 CDS An08g09460 4983264 complement(join(2245045..2245770,2246134..2246363,2246417..2246492)) VIII 1 NT_166524.1 Catalytic activity: nitrate reductases catalyse the reaction, NADH + nitrate <=> NAD(+) + nitrite + H(2)O.; Function: nitrate reductases are key enzymes in the assimilation of nitrate.; Title: strong similarity to nitrate reductase NIA1 -Arabidopsis thaliana; See PMID 9233539; uncharacterized protein 2246492 4983264 An08g09460 Aspergillus niger uncharacterized protein XP_059606212.1 2245045 R 5061 CDS An08g09470 4983265 join(2247003..2247135,2247178..2247214,2247299..2247451,2247535..2248391,2248458..2249094,2249355..2249360,2249428..2249486,2249587..2249609) VIII 1 NT_166524.1 Catalytic activity: cytochrome P450 proteins catalyse the reaction, RH + reduced flavoprotein + O(2) = ROH + oxidised flavoprotein + H(2)O.; Function: P450 enzymes usually act as terminal oxidases in multicomponent electron transfer.; Similarity: the ORF is longer than CYPF16 (634 compared to 524 amino acids), the homology between the two proteins spans more than 350 amino acids.; Similarity: the ORF shows similaritiy to many cytochrome P450 proteins.; Title: strong similarity to cytochrome P450 CYP4F16 - Mus musculus; See PMID 9501474; See PMID 11160642; uncharacterized protein 2249609 4983265 An08g09470 Aspergillus niger uncharacterized protein XP_059606213.1 2247003 D 5061 CDS An08g09490 4983267 complement(join(2250258..2250669,2250734..2250916,2250974..2251545,2251639..2251719,2251773..2252083,2252141..2252418,2252570..2252721)) VIII 1 NT_166524.1 Function: ctf1 alpha of F. solani is a DNA binding,transcription regulator.; Similarity: the predicted A. niger protein shows similarity to the Cys6Zn2 binuclear cluster of the Gal4 superfamily proteins.; Title: strong similarity to cutinase transcription factor alpha CTF1a - Fusarium solani; nucleus; See PMID 9139694; uncharacterized protein 2252721 4983267 An08g09490 Aspergillus niger uncharacterized protein XP_059606214.1 2250258 R 5061 CDS An08g09500 84591797 join(2254112..2254230,2254945..2255075,2255154..2255648,2255716..2256330,2256401..2257659) VIII 1 NT_166524.1 Remark: similarity is from C-terminus of predicted A. niger protein to central region of L. pealii kinesin,which is 300 aa shorter.; Title: similarity to kinesin light chain - Loligo pealei; cytoskeleton; uncharacterized protein 2257659 84591797 An08g09500 Aspergillus niger uncharacterized protein XP_059606215.1 2254112 D 5061 CDS An08g09510 84591798 join(2259251..2259669,2259715..2259772,2260052..2260633) VIII 1 NT_166524.1 Remark: ankyrin repeats are often contained in other proteins (which are not classified with the ankyrin family) and ensure protein-protein interactions as well as interactions between proteins and nucleic acids.; Similarity: the predicted A. niger protein shows also strong similarity to domains of ankyrin.; Title: weak similarity to death associated protein kinase Dapk1 - Mus musculus; uncharacterized protein 2260633 84591798 An08g09510 Aspergillus niger uncharacterized protein XP_059606216.1 2259251 D 5061 CDS An08g09520 84591799 complement(join(2260800..2261665,2261927..2262099,2262165..2262274)) VIII 1 NT_166524.1 Function: ankyrins act as protein linker between the integral membrane proteins and spectrin-based cytoskeleton.; Remark: ankyrin repeats are often contained in other proteins (which are not classified with the ankyrin family) and ensure protein-protein interactions as well as interactions between proteins and nucleic acids.; Similarity: the predicted A. niger protein shows similarity to repetitive domains of ankyrin.; Title: similarity to ankyrin 2 Ank2 - Drosophila melanogaster; See PMID 10810176; See PMID 10844021; uncharacterized protein 2262274 84591799 An08g09520 Aspergillus niger uncharacterized protein XP_059606217.1 2260800 R 5061 CDS An08g09530 84591800 join(2263380..2263542,2263598..2264118,2264218..2264289,2264548..2264629,2264714..2264778,2264824..2264967,2265145..2265211,2265310..2265575) VIII 1 NT_166524.1 Induction: spoVK/spoVJ from B. subtilis has an interesting pattern of regulation during sporulation because it is expressed from sequentially activated promoters, that are under the control of different sigma factors, sigma E and sigma K.; Remark: spoVK and spoVJ from B. subtilis are identical.; Remark: spoVK/spoVJ from B. subtilis is expressed only in the mother cell.; Similarity: the predicted A. niger protein shows similarity to spore formation protein spoVK from B. subtilis, which belongs to the CBXX/CFQX family.; Title: similarity to spore formation protein spoVK -Bacillus subtilis; uncharacterized protein 2265575 84591800 An08g09530 Aspergillus niger uncharacterized protein XP_059606218.1 2263380 D 5061 CDS An08g09540 84591801 join(2265945..2266133,2266164..2266546,2266886..2267007,2267322..2267401,2267482..2267533,2267623..2267702,2267790..2267942) VIII 1 NT_166524.1 Title: weak similarity to microtubule-based motor HsKIFC3 - Homo sapiens; uncharacterized protein 2267942 84591801 An08g09540 Aspergillus niger uncharacterized protein XP_059606219.1 2265945 D 5061 CDS An08g09550 4983273 join(2268086..2268389,2268438..2268916,2268979..2269444,2269521..2269633,2269707..2270066) VIII 1 NT_166524.1 Catalytic activity: a Phenol sulfate + H2O = a Phenol + Sulfate.; Function: ars-1 from N. crassa catalyzes the hydrolysis of Sulfate esters.; Regulation: N. crassa ars-1 belongs to a group of highly regulated sulfur-related structural genes that are expressed under conditions of sulfur limitation and are under coordinate control of the cys-3 and scon regulatory genes.; Title: strong similarity to arylsulfatase ars-1 -Neurospora crassa; See PMID 2528685; uncharacterized protein 2270066 4983273 An08g09550 Aspergillus niger uncharacterized protein XP_059606220.1 2268086 D 5061 CDS An08g09560 84591802 join(2270865..2271022,2271084..2271591,2271666..2272346) VIII 1 NT_166524.1 Remark: human early growth response protein 1 is a zinc-finger protein.; Title: similarity to early growth response protein 1 - Homo sapiens; nucleus; See PMID 9109500; uncharacterized protein 2272346 84591802 An08g09560 Aspergillus niger uncharacterized protein XP_059606221.1 2270865 D 5061 CDS An08g09570 4983275 join(2273839..2273919,2274001..2274912,2274992..2275172,2275270..2275493,2275727..2275858) VIII 1 NT_166524.1 Function: in rat MCT3 is the major MCT isoform responsible for efflux of glycolytically derived lactic acid from white skeletal muscle, however it is also able to import lactic acid.; Title: similarity to monocarboxylate transporter MCT3 - Rattus norvegicus; See PMID 9632638; uncharacterized protein 2275858 4983275 An08g09570 Aspergillus niger uncharacterized protein XP_059606222.1 2273839 D 5061 CDS An08g09580 4983276 complement(2276585..2277550) VIII 1 NT_166524.1 Similarity: the ORF shows N-terminal similarity to the hypothetical protein of C. burnetii over a stretch of about 200 amino acids.; Title: strong similarity to hypothetical protein encoded by An14g06160 - Aspergillus niger; uncharacterized protein 2277550 4983276 An08g09580 Aspergillus niger uncharacterized protein XP_001393068.1 2276585 R 5061 CDS An08g09590 84591803 join(2281816..2281970,2282087..2282198) VIII 1 NT_166524.1 Title: similarity to secreted protein from patent WO9947540-A1 - Homo sapiens; uncharacterized protein 2282198 84591803 An08g09590 Aspergillus niger uncharacterized protein XP_059606223.1 2281816 D 5061 CDS An08g09600 84591804 join(2283227..2283268,2283692..2283729,2283819..2283852,2283923..2283982,2284225..2284378,2284532..2284575) VIII 1 NT_166524.1 Title: similarity to hypothetical protein BH3375 -Bacillus halodurans; uncharacterized protein 2284575 84591804 An08g09600 Aspergillus niger uncharacterized protein XP_059606224.1 2283227 D 5061 CDS An08g09610 4983279 complement(2284916..2286310) VIII 1 NT_166524.1 Function: mutanase mutA of P. purporogenum exhibit strong binding to insoluble mutan.; Function: mutanases are alpha1,3-glucanases.; Remark: mutA of P. purporogenum is about 200 aminoacids longer at C-terminus.; Title: similarity to mutanase mutA - Penicillium purpurogenum; See PMID 10636904; uncharacterized protein 2286310 4983279 An08g09610 Aspergillus niger uncharacterized protein XP_001393071.1 2284916 R 5061 CDS An08g09620 4983280 complement(join(2287984..2288141,2288238..2288268,2288434..2289490,2289540..2289689,2289739..2290257,2290308..2290361,2290417..2290541)) VIII 1 NT_166524.1 Remark: the similarity to facB covers the N-terminal 280 amino acids.; Title: weak similarity to regulator protein of the lovastatin biosynthesis lovE - Aspergillus terreus; uncharacterized protein 2290541 4983280 An08g09620 Aspergillus niger uncharacterized protein XP_001393072.3 2287984 R 5061 CDS An08g09630 4983281 complement(join(2290814..2290901,2291003..2291421,2291474..2291666,2291728..2291795)) VIII 1 NT_166524.1 Remark: shows also similarity to several hypothetical prokaryontic transcriptional regulators.; Title: similarity to hypothetical protein SC5F2A.30 - Streptomyces coelicolor; uncharacterized protein 2291795 4983281 An08g09630 Aspergillus niger uncharacterized protein XP_001393073.3 2290814 R 5061 CDS An08g09640 4983282 complement(join(2292204..2292717,2292772..2293163,2293237..2293344,2293489..2293557)) VIII 1 NT_166524.1 Remark: might be a putative pseudogene.; Similarity: similarity is restricted to part of M. grisea protein.; Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea; uncharacterized protein 2293557 4983282 An08g09640 Aspergillus niger uncharacterized protein XP_059606225.1 2292204 R 5061 CDS An08g09650 84591805 join(2295987..2296027,2296094..2296283) VIII 1 NT_166524.1 Remark: shows similarity only to the N-terminal part of several dihydrodiol dehydrogenases, might be a putative pseudogene.; Title: weak similarity to dihydrodiol dehydrogenase phdE - Nocardioides sp. [putative pseudogene]; uncharacterized protein 2296283 84591805 An08g09650 Aspergillus niger uncharacterized protein XP_059606226.1 2295987 D 5061 CDS An08g09660 84591806 join(2296651..2296740,2296795..2296905) VIII 1 NT_166524.1 hypothetical protein 2296905 84591806 An08g09660 Aspergillus niger hypothetical protein XP_059606227.1 2296651 D 5061 CDS An08g09670 84591807 complement(2297503..2297892) VIII 1 NT_166524.1 Remark: might be a putative pseudogene.; Similarity: show similarity to C-terminal part of several NADH dehydrogenases.; Title: weak similarity to subunit of NADH:ubiquinone reductase - Cyprinodon variegatus [putative sequencing error]; putative sequencing error; uncharacterized protein 2297892 84591807 An08g09670 Aspergillus niger uncharacterized protein XP_059606228.1 2297503 R 5061 CDS An08g09680 4983286 2298221..2298763 VIII 1 NT_166524.1 Catalytic activity: 2,4'-dihydroxyacetophenone dioxygenase catalyzes the conversion of 2,4'-dihydroxyacetophenone + O2 = 4-hydroxybenzoate + formate.; Function: 2,4'-dihydroxyacetophenone dioxygenase of Alcaligenes is involved in 4-hydroxyacetophenone degradation.; Title: strong similarity to 2,4-dihydroxyacetophenone dioxygenase dad - Alcaligenes sp.; See PMID 10567221; uncharacterized protein 2298763 4983286 An08g09680 Aspergillus niger uncharacterized protein XP_001393078.1 2298221 D 5061 CDS An08g09690 4983287 complement(join(2299241..2299647,2299836..2299906,2299963..2300040,2300095..2300630)) VIII 1 NT_166524.1 Title: weak similarity to secreted protein from patent WO9844113-A1 - Homo sapiens; uncharacterized protein 2300630 4983287 An08g09690 Aspergillus niger uncharacterized protein XP_059606229.1 2299241 R 5061 CDS An08g09700 4983288 complement(join(2301147..2301434,2301492..2302062,2302119..2302199,2302255..2302341,2302404..2302528)) VIII 1 NT_166524.1 Catalytic activity: aryl alcohol dehydrogenases catalyze the conversion of an aromatic alcohol + NADP+ = an aromatic aldehyde + NADPH.; Function: norsolorinic acid reductase norA of A. parasiticus is involved in aflatoxin biosynthesis.; Remark: aflatoxins are polyketide-derived secondary metabolites.; Similarity: shows also strong similarity to several aryl-alcohol dehyrogenases.; Title: strong similarity to norsolorinic acid reductase norA - Aspergillus parasiticus; See PMID 8593042; uncharacterized protein 2302528 4983288 An08g09700 Aspergillus niger uncharacterized protein XP_001393080.1 2301147 R 5061 CDS An08g09710 4983289 complement(join(2304217..2304362,2304428..2304905,2304958..2305395)) VIII 1 NT_166524.1 Similarity: shows similarity to several Sphingomonas enzymes involved in aromate catabolism.; Title: similarity to 2,2-dihydroxy-3,3-dimethoxy-5,5-dicarboxybiphenyl meta-cleavage compound hydrolase ligY -Sphingomonas paucimobilis; See PMID 9647824; uncharacterized protein 2305395 4983289 An08g09710 Aspergillus niger uncharacterized protein XP_001393081.1 2304217 R 5061 CDS An08g09720 4983290 join(2305513..2305597,2305679..2305775,2305890..2306056,2306159..2306281,2306356..2306405,2306485..2306797,2306862..2306919,2306969..2307323) VIII 1 NT_166524.1 Function: M. grisea Pth11p functions at the cell cortex as an upstream effector of appressorium differentiation in response to surface cues.; Similarity: the M. grisea Pth11p is about 200 aminoacids longer at C-terminus.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529; uncharacterized protein 2307323 4983290 An08g09720 Aspergillus niger uncharacterized protein XP_059606230.1 2305513 D 5061 CDS An08g09740 84591808 complement(join(2308425..2308496,2308769..2308825,2308923..2309213,2309342..2310436,2310532..2310660)) VIII 1 NT_166524.1 hypothetical protein 2310660 84591808 An08g09740 Aspergillus niger hypothetical protein XP_059606231.1 2308425 R 5061 CDS An08g09750 4983293 complement(join(2312456..2313147,2313204..2313494,2313556..2313664)) VIII 1 NT_166524.1 Catalytic activity: alcohol dehydrogenases convert alcohol + NAD(+) to aldehyde or ketone + NADH.; Catalytic activity: it requires zinc as cofactor.; Title: strong similarity to alcohol dehydrogenase adh1p - Schizosaccharomyces pombe; cytoplasm; See PMID 6294096; uncharacterized protein 2313664 4983293 An08g09750 Aspergillus niger uncharacterized protein XP_001393084.3 2312456 R 5061 CDS An08g09760 4983294 2315444..>2317122 VIII 1 NT_166524.1 Function: FMOs have been implicated in the metabolism of a number of pharmaceuticals, pesticides and toxicants.; Function: flavin-containing monooxygenases (FMOs) constitute a family of xenobiotic-metabolising enzymes.; Function: using an NADPH cofactor and FAD prosthetic group, these microsomal proteins catalyse the oxygenation of nucleophilic nitrogen, sulphur, phosphorous and selenium atoms in a range of structurally diverse compounds.; Remark: putative frameshift at position 7783, one bp might be missing.; Title: strong similarity to cyclohexanone monooxygenase chnB2 - Brevibacterium sp. [putative frameshift]; putative frameshift; See PMID 10894733; uncharacterized protein 2317122 4983294 An08g09760 Aspergillus niger uncharacterized protein XP_001393085.3 2315444 D 5061 CDS An08g09770 84591809 join(2317461..2317806,2317900..2318035,2318152..2318452,2318530..>2318966) VIII 1 NT_166524.1 Function: the carboxylesterase from B. linens is responsible for the conversion of 1,4-butanediol diacrylate to 4-hydroxybutyl acrylate.; Remark: putative frameshift at position 5478; one bp might be missing.; Similarity: shows also similarity to other esterases.; Title: strong similarity to 1,4-butanediol diacrylate esterase BDA1 - Brevibacterium linens [putative frameshift]; putative frameshift; See PMID 10361681; uncharacterized protein 2318966 84591809 An08g09770 Aspergillus niger uncharacterized protein XP_059606232.1 2317461 D 5061 CDS An08g09780 4983296 join(2320376..2320533,2320606..2320681,2320792..2321471,2321608..2321708,2321749..2321760,2321836..2321873) VIII 1 NT_166524.1 Title: weak similarity to hypothetical protein SC8F4.26 - Streptomyces coelicolor; uncharacterized protein 2321873 4983296 An08g09780 Aspergillus niger uncharacterized protein XP_059606233.1 2320376 D 5061 CDS An08g09790 84591810 join(2323425..2323431,2323524..2323590,2323810..2324092) VIII 1 NT_166524.1 hypothetical protein 2324092 84591810 An08g09790 Aspergillus niger hypothetical protein XP_059606234.1 2323425 D 5061 CDS An08g09800 4983298 2324724..2326499 VIII 1 NT_166524.1 Catalytic activity: tannase of A. oryzae hydrolyzes the ester bonds of tannic acid to produce gallic acid and glucose.; Remark: tannin acyl hydrolase is an alternativ name for tannase.; Title: strong similarity to precursor of tannase -Aspergillus oryzae; See PMID 8917102; uncharacterized protein 2326499 4983298 An08g09800 Aspergillus niger uncharacterized protein XP_001393089.1 2324724 D 5061 CDS An08g09810 4983299 complement(2327514..2328446) VIII 1 NT_166524.1 hypothetical protein 2328446 4983299 An08g09810 Aspergillus niger hypothetical protein XP_001393090.1 2327514 R 5061 CDS An08g09820 84591811 join(2329156..2329247,2329401..2329451,2329484..2329505) VIII 1 NT_166524.1 hypothetical protein 2329505 84591811 An08g09820 Aspergillus niger hypothetical protein XP_059606235.1 2329156 D 5061 CDS An08g09830 84591812 join(2331038..2332487,2332556..2332575) VIII 1 NT_166524.1 Title: similarity to hypothetical protein encoded by An02g10630 - Aspergillus niger; uncharacterized protein 2332575 84591812 An08g09830 Aspergillus niger uncharacterized protein XP_059606236.1 2331038 D 5061 CDS An08g09840 84591813 complement(join(2332869..2333009,2333141..2333220,2333292..2333673,2333753..2333782)) VIII 1 NT_166524.1 Title: strong similarity to cysteine proteinase polypeptide from patent WO200268623-A2 - Aspergillus niger; uncharacterized protein 2333782 84591813 An08g09840 Aspergillus niger uncharacterized protein XP_059606237.1 2332869 R 5061 CDS An08g09850 4983303 complement(join(2334536..2335329,2335377..2335667,2335719..2335863,2335920..2336102)) VIII 1 NT_166524.1 Catalytic activity: acid phosphatases also catalyse transphosphorylations.; Catalytic activity: acid phosphatases catalize the reaktion of orthophosphoric monoester + H(2)O = an alcohol + phosphate.; Remark: acid phosphatases show a wide specificity.; Title: strong similarity to phosphate-repressible acid phosphatase precursor phoA - Penicillium chrysogenum; See PMID 1563629; uncharacterized protein 2336102 4983303 An08g09850 Aspergillus niger uncharacterized protein XP_001393094.1 2334536 R 5061 CDS An08g09860 84591814 complement(join(2337617..2338270,2338351..2338509,2338570..2338697,2338752..2339052)) VIII 1 NT_166524.1 Title: similarity to protein SEQ ID NO:53564 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 2339052 84591814 An08g09860 Aspergillus niger uncharacterized protein XP_059606238.1 2337617 R 5061 CDS An08g09870 4983305 complement(join(2339478..2340018,2340087..2340421)) VIII 1 NT_166524.1 Pathway: CmcJ catalyzes late reaction in the cephamycin biosynthetic pathway.; Similarity: the ORF encoded protein also shows similarity to C-7 hydroxycephem methyltransferase coupling protein from patent R92153.; Title: similarity to methyltransferase CmcJ -Streptomyces clavuligerus; See PMID 9696752; uncharacterized protein 2340421 4983305 An08g09870 Aspergillus niger uncharacterized protein XP_001393096.1 2339478 R 5061 CDS An08g09880 4983306 complement(join(2342153..2342209,2342254..2342306,2342360..2342525)) VIII 1 NT_166524.1 Title: weak similarity to hydrophobin CoH1 -Coprinus cinereus; uncharacterized protein 2342525 4983306 An08g09880 Aspergillus niger uncharacterized protein XP_059606239.1 2342153 R 5061 CDS An08g09900 4983307 complement(join(2345384..2345485,2345518..2345631,2345689..2345776,2345830..2346474,2346525..2347380,2347414..2348062)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein encoded by An08g01250 - Aspergillus niger; uncharacterized protein 2348062 4983307 An08g09900 Aspergillus niger uncharacterized protein XP_059606240.1 2345384 R 5061 CDS An08g09910 84591815 join(2348845..2349864,2350003..2350189,2350246..2350607) VIII 1 NT_166524.1 Title: weak similarity to hypothetical protein MMJ24.4 - Arabidopsis thaliana; uncharacterized protein 2350607 84591815 An08g09910 Aspergillus niger uncharacterized protein XP_059606241.1 2348845 D 5061 CDS An08g09920 4983309 join(2351932..2352030,2352116..2352547) VIII 1 NT_166524.1 Catalytic activity: scytalone dehydratases catalize the reaction of Scytalone <=> 1,3,8-trihydroxynaphthalene + H(2)O.; Function: pathogenic fungi use melanin in the penetration of host plants.; Pathway: scytalone dehydratases are involved in the biosynthesis of melanin in pathogenic fungi.; Title: strong similarity to scytalone dehydratase -Pyricularia oryzae; See PMID 9571787; uncharacterized protein 2352547 4983309 An08g09920 Aspergillus niger uncharacterized protein XP_001393100.1 2351932 D 5061 CDS An08g09930 84591816 complement(join(2353363..2353821,2353905..2354641,2354877..>2354967)) VIII 1 NT_166524.1 Remark: the ORF encoded protein is N-terminally truncated due to the contig border. .; Title: weak similarity to hypothetical protein encoded by An11g05870 - Aspergillus niger [truncated ORF]; uncharacterized protein 2354967 84591816 An08g09930 Aspergillus niger uncharacterized protein XP_059606242.1 2353363 R 5061 CDS An08g09940 4983311 complement(join(2356855..2357193,2357252..2358385)) VIII 1 NT_166524.1 Function: involved in trichothecene biosynthesis in Fusarium sporotrichioides.; Remark: TRI11 of Fusarium sporotrichioides encodes a cytochrome P-450 monooxygenase.; Remark: trichothecenes are sesquiterpenoid epoxides that act as potent inhibitors of eukaryotic protein synthesis.; Title: strong similarity to cytochrome P450 monooxygenase TRI11 - Fusarium sporotrichioides; See PMID 8246841; uncharacterized protein 2358385 4983311 An08g09940 Aspergillus niger uncharacterized protein XP_001393102.1 2356855 R 5061 CDS An08g09950 84591817 join(2359238..2359417,2359473..2359628,2359769..2359849) VIII 1 NT_166524.1 Function: profilin controlls actin polymerisability.; Remark: significant blast hits are only found in the SCOP database.; Title: weak similarity to profilin 1 - Arabidopsis thaliana; See PMID 2257632; uncharacterized protein 2359849 84591817 An08g09950 Aspergillus niger uncharacterized protein XP_059601246.1 2359238 D 5061 CDS An08g09960 4983313 join(2360553..2361239,2361452..2361601,2361648..2361710) VIII 1 NT_166524.1 Remark: Raf-1 kinase of Xenopus laevis is a potential regulator of intracellular pH in oocytes.; Similarity: the ORF is about half as long as the Raf-1 kinase of X. laevis (299 compared to 638 amino acids). Only 120 amino acids are encompassed by the alignment between the two molecules.; Title: similarity to protein kinase raf-1 - Xenopus laevis; See PMID 9923073; uncharacterized protein 2361710 4983313 An08g09960 Aspergillus niger uncharacterized protein XP_001393104.3 2360553 D 5061 CDS An08g09970 4983314 join(2364150..2364761,2364859..2367774) VIII 1 NT_166524.1 Remark: the HET-E gene of the fungus Podospora anserina is responsible for vegetative incompatibility.; Similarity: the c-terminal part of the ORF encoded protein shows weak similarity to the human myosin heavy chain MYH8.; Title: similarity to beta-transducin-like protein het-e - Podospora anserina; See PMID 9435787; See PMID 7557402; uncharacterized protein 2367774 4983314 An08g09970 Aspergillus niger uncharacterized protein XP_059604150.1 2364150 D 5061 CDS An08g09980 4983315 complement(join(2368320..2369275,2369395..2369510,2369588..2369861,2369982..2370006)) VIII 1 NT_166524.1 Catalytic activity: UDP-glucose + 2 NAD(+) + H(2)O <=> UDP-glucuronate + 2 NADH.; Pathway: the UDPGDH product from D. melanogaster is involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.; Remark: alternate names for UDP-glucose dehydrogenase UDPGDH from D. melanogaster: sugarless or sgl.; Title: strong similarity to UDP-glucose dehydrogenase UDPGDH - Drosophila melanogaster; See PMID 9862465; uncharacterized protein 2370006 4983315 An08g09980 Aspergillus niger uncharacterized protein XP_059604151.1 2368320 R 5061 CDS An08g09990 84591818 complement(join(2370887..2370998,2371120..2371160,2371474..2371564,2371685..2371813,2371870..2372375)) VIII 1 NT_166524.1 Pathway: the CapB enzyme from S. pneumoniae is involved in the production of the type 3 pneumococcal capsule, which is composed of cellobiuronic acid units connected in a beta (1-->3) linkage.; Title: similarity to synthase of the type 3 pneumococcal capsular polysaccharide CapB - Streptococcus pneumoniae; See PMID 9109098; uncharacterized protein 2372375 84591818 An08g09990 Aspergillus niger uncharacterized protein XP_059604152.1 2370887 R 5061 CDS An08g10000 4983317 complement(join(<2373829..2374718,2374772..2375483,2375536..2375630)) VIII 1 NT_166524.1 Complex: the human cytochrome b245 beta chain CYBB forms a complex with the alpha chain CYBA.; Function: the human CYBB gene product is a critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. It also functions as a voltage-gated proton channel that mediates the H+ currents of restingphagocytes. It also participates in the regulation of cellular pH and is blocked by zinc.; Localization: the human CYBB gene product is a integral membrane protein.; Remark: a putative sequencing error results in an frameshift.; Remark: chronic granulomatous disease (CGD) is a rare inherited disorder associated with a profound predisposition to infection due to the lack of a microbicidal oxidase system in the phagocytes of these patients. This disorder is characterized by the absence of functional plasma-membrane-associated NADPH oxidase due to a defect in human beta-chain of cytochrome b-245) protein (X-CGD or CYBB gene).; Title: strong similarity to cytochrome b245 beta chain CYBB - Homo sapiens [putative frameshift]; putative frameshift; See PMID 10578014; See PMID 3600768; See PMID 3600769; uncharacterized protein 2375630 4983317 An08g10000 Aspergillus niger uncharacterized protein XP_059604153.1 2373829 R 5061 CDS An08g10010 4983318 join(2378501..2378558,2378624..2378940,2378991..2379038,2379163..2379285) VIII 1 NT_166524.1 hypothetical protein 2379285 4983318 An08g10010 Aspergillus niger hypothetical protein XP_001393109.3 2378501 D 5061 CDS An08g10020 4983319 2379767..2380804 VIII 1 NT_166524.1 Function: In the DNA of higher eukaryotes,hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of g/t mismatches. The human TDG enzyme corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs i the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.; Remark: for the mouse TDG interaction to DNA-binding transciption factors (etc. c-Jun, RAR) could be shown.; Similarity: the ORF encoded protein shows stronger similarity to the mouse TDG homologue, but this enzyme is not as well characterized as the human TDG.; Title: strong similarity to G/T mismatch-specific thymine-DNA glycosylase TDG - Homo sapiens; nucleus; See PMID 9144158; See PMID 8407958; uncharacterized protein 2380804 4983319 An08g10020 Aspergillus niger uncharacterized protein XP_001393110.1 2379767 D 5061 CDS An08g10030 4983320 complement(join(2381086..2381139,2381208..2381331,2381396..2381559)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical MF-7 antigenic protein from patent WO9721817-A1 - Malassezia sp.; uncharacterized protein 2381559 4983320 An08g10030 Aspergillus niger uncharacterized protein XP_001393111.1 2381086 R 5061 CDS An08g10040 4983321 complement(join(2382274..2383206,2383275..2383529,2383587..2383805,2383857..2384057,2384113..2384421,2384499..2385038)) VIII 1 NT_166524.1 Function: the mouse vav-oncogene is probable exchange factor for a small Ras-like GTP-binding protein. It can be activated by truncation of the n-terminus.; Title: similarity to GTP/GDP exchange factor and proto-oncogene vav - Mus musculus; See PMID 9058837; See PMID 1565462; uncharacterized protein 2385038 4983321 An08g10040 Aspergillus niger uncharacterized protein XP_059604154.1 2382274 R 5061 CDS An08g10050 4983322 join(2385903..2386058,2386129..2386201,2386252..2386595,2386682..2386813) VIII 1 NT_166524.1 Complex: the rat Bridge (Bridge-1) protein interacts with E2A family of basic helix-loop-helix transcription factors (e. g. E12/E47 proteins).; Function: Bridge-1 from rat, by utilizing its PDZ-like domain to interact with E12, may provide a new mechanism for the coactivation and regulation of transcription of the insulin gene.; Similarity: the Bridge-1 protein from Rattus norvegicus also shows similarity to the proteasome subunit p27.; Title: strong similarity to transactivating protein BRIDGE - Rattus norvegicus; See PMID 10567574; uncharacterized protein 2386813 4983322 An08g10050 Aspergillus niger uncharacterized protein XP_001393113.3 2385903 D 5061 CDS An08g10060 4983323 join(2387448..2387507,2387718..2387810,2387883..2388036,2388105..2388310,2388376..2388507) VIII 1 NT_166524.1 Function: the Gsp1 (CaGsp1) protein from Candida albicans is a GTP-binding protein involved in nucleocytoplasmic transport. It is required for the import of protein into the nucleus and also for RNA export.; Remark: the C. albicans CaGSP1 gene is able to complement a gsp1 S. cerevisiae mutant.; Similarity: the C. albicans CaGsp1 protein and the S. cerevisiae Gsp1/Gsp2 proteins belong to the Ran family in the Ras superfamily.; Similarity: the ORF encoded protein shows also strong similarity to Gsp1 from S. cerevisiae, which is much better characterized.; Title: strong similarity to small G-protein Gsp1 -Candida albicans; See PMID 10854789; uncharacterized protein 2388507 4983323 An08g10060 Aspergillus niger uncharacterized protein XP_001393114.1 2387448 D 5061 CDS An08g10070 4983324 complement(join(2389451..2389582,2389856..2390501,2390685..2391316,2391377..>2392117)) VIII 1 NT_166524.1 Function: the S. cerevisae Rad16 protein involved in differential repair of DNA after UV damage. It will repair preferentially the MAT-alpha locus compaired with the HML-alpha locus.; Remark: N-terminal truncated ORF due to the end of contig.; Title: strong similarity to DNA repair protein Rad16 - Saccharomyces cerevisiae [truncated ORF]; nucleus; See PMID 8910442; See PMID 1508678; See PMID 7553931; uncharacterized protein 2392117 4983324 An08g10070 Aspergillus niger uncharacterized protein XP_059604155.1 2389451 R 5061 CDS An08g10080 84591819 complement(2392323..2393573) VIII 1 NT_166524.1 Remark: the similarity is only to a short domain of the MHC class III protein.; Title: weak similarity to MHC class III histocompatibility antigen HLA-B-associated transcript BAT2 - Homo sapiens; See PMID 2156268; uncharacterized protein 2393573 84591819 An08g10080 Aspergillus niger uncharacterized protein XP_059601247.1 2392323 R 5061 CDS An08g10090 84591820 complement(join(2394066..2394109,2394192..2394383,2394507..2394531)) VIII 1 NT_166524.1 hypothetical protein 2394531 84591820 An08g10090 Aspergillus niger hypothetical protein XP_059601248.1 2394066 R 5061 CDS An08g10100 4983327 complement(join(2395352..2395479,2395640..2395973,2396032..2396364,2396412..2396523,2396664..2396717,2396940..2397427,2397498..2397701)) VIII 1 NT_166524.1 Remark: Polyketides, the ubiquitous products of secondary metabolism in microorganisms, are made by a process resembling fatty acid biosynthesis that allows the suppression of reduction or dehydration reactions at specific biosynthetic steps.; Title: strong similarity to cytochrome P450 monooxygenase lovA - Aspergillus terreus; See PMID 10334994; uncharacterized protein 2397701 4983327 An08g10100 Aspergillus niger uncharacterized protein XP_059601249.1 2395352 R 5061 CDS An08g10110 4983328 join(2399954..2399969,2400038..2400247,2400316..2400479) VIII 1 NT_166524.1 Remark: the POX18 protein in c. tropicalis is one of the oleate-inducible peroxisomal proteins.; Remark: the PXP-18 has a role in the beta-oxidation of long-chain fatty acids.; Remark: the protein shows strong similarity to sterol carrier protein from different eukaryotes.; Title: strong similarity to lipid transfer protein POX18 - Candida tropicalis; See PMID 2364939; See PMID 2470648; uncharacterized protein 2400479 4983328 An08g10110 Aspergillus niger uncharacterized protein XP_001393119.1 2399954 D 5061 CDS An08g10120 84591821 join(2401307..2401378,2401475..2401634,2401728..2401897) VIII 1 NT_166524.1 hypothetical protein 2401897 84591821 An08g10120 Aspergillus niger hypothetical protein XP_059601250.1 2401307 D 5061 CDS An08g10130 4983330 join(2402642..2402703,2402971..2406916) VIII 1 NT_166524.1 Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: blastp results correspond to serine,threonine and proline rich regions.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 9987114; See PMID 11152942; See PMID 8710886; See PMID 9383611; uncharacterized protein 2406916 4983330 An08g10130 Aspergillus niger uncharacterized protein XP_001393121.1 2402642 D 5061 CDS An08g10140 4983331 complement(join(2408096..2408302,2408382..2408456,2408891..2408980)) VIII 1 NT_166524.1 Remark: the L31 protein is known in many different organisms.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L31 - Saccharomyces cerevisiae; cytoplasm; See PMID 10588049; See PMID 2666132; See PMID 6355773; 60S ribosomal protein eL31 2408980 4983331 An08g10140 Aspergillus niger 60S ribosomal protein eL31 XP_001393122.1 2408096 R 5061 CDS An08g10150 4983332 complement(join(2409454..2410280,2410371..2410425)) VIII 1 NT_166524.1 Catalytic activity: a Nitrile + H2O = a Carboxylate + NH3.; Pathway: Tryptophan metabolism; Cyanoamino acid metabolism; Nitrogen metabolism.; Remark: Acts on a wide range of aromatic nitriles including (indole-3-yl)acetonitrile, and also on some aliphatic nitriles, and on the corresponding acid amides.; Remark: Fhit occurs in a fusion protein, NitFhit, in D. melanogaster and C. elegans although FHIT and NIT1 are separate genes in mammalian cells.; Remark: the human and mouse NIT1 genes are members of an uncharacterized mammalian gene family with homology to bacterial and plant nitrilases, enzymes that cleave nitriles and organic amides to the corresponding carboxylic acids plus ammonia.; Title: strong similarity to nitrilase Nit1 - Mus musculus; See PMID 9671749; See PMID 10959838; uncharacterized protein 2410425 4983332 An08g10150 Aspergillus niger uncharacterized protein XP_001393123.1 2409454 R 5061 CDS An08g10160 84591822 join(2411771..2412572,2412748..2413037) VIII 1 NT_166524.1 Similarity: blastp matches are mainly based on repetetive structures.; hypothetical protein 2413037 84591822 An08g10160 Aspergillus niger hypothetical protein XP_059601251.1 2411771 D 5061 CDS An08g10170 4983334 complement(join(2414764..2414858,2414914..2415761,2415805..2415869)) VIII 1 NT_166524.1 Remark: Patentno: R87508.; Remark: Synthetic jojoba fatty acyl reductase gene having reduced AT content used in the production of wax ester in plant cells not naturally producing wax ester.; Title: weak similarity to fatty-acyl-reductase from patent WO9533055-A2 - Brassica sp.; uncharacterized protein 2415869 4983334 An08g10170 Aspergillus niger uncharacterized protein XP_059601252.1 2414764 R 5061 CDS An08g10180 4983335 join(2417562..2418518,2418839..2418979) VIII 1 NT_166524.1 hypothetical protein 2418979 4983335 An08g10180 Aspergillus niger hypothetical protein XP_001393126.3 2417562 D 5061 CDS An08g10190 4983336 complement(join(2419597..2420520,2420575..2420645,2420711..2421110)) VIII 1 NT_166524.1 Title: weak similarity to hypothetical protein VeA -Neurospora crassa; uncharacterized protein 2421110 4983336 An08g10190 Aspergillus niger uncharacterized protein XP_001393127.3 2419597 R 5061 CDS An08g10200 84591823 complement(join(2422934..2423096,2423188..2423230,2423373..2423466)) VIII 1 NT_166524.1 hypothetical protein 2423466 84591823 An08g10200 Aspergillus niger hypothetical protein XP_059601253.1 2422934 R 5061 CDS An08g10210 4983338 join(2424454..2424535,2424583..2424742,2424792..2424984,2425038..2425390,2425436..2425642,2425700..2425977,2426025..2426719) VIII 1 NT_166524.1 Remark: also weak similarity to other transcriptional regulators in different organisms.; Title: weak similarity to suppressor protein SEF1 -Kluyveromyces lactis; uncharacterized protein 2426719 4983338 An08g10210 Aspergillus niger uncharacterized protein XP_059606243.1 2424454 D 5061 CDS An08g10220 10098019 complement(join(2427546..2427702,2427757..2427908,2428043..2428199,2428626..2432962)) VIII 1 NT_166524.1 Catalytic activity: Deoxynucleoside triphosphate + DNA(n) = Pyrophosphate + DNA(n+1).; Remark: catalyses RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo. Requires an RNA or DNA primer. DNA can also serve as template.; Remark: in plants, retrotransposons have been described in maize, Arabidopsis and wheat, and non-viral retroposons in maize.; Remark: transcription and transposition of Tto1 were observed in rice cells.; Title: strong similarity to retrotransposon Tto1 -Nicotiana tabacum; See PMID 8624443; See PMID 2536143; uncharacterized protein 2432962 10098019 An08g10220 Aspergillus niger uncharacterized protein XP_003188761.2 2427546 R 5061 CDS An08g10260 4983340 join(2433727..2434016,2434114..2434541,2434605..2434843,2434931..2434946,2434987..2434999,2435035..2435059) VIII 1 NT_166524.1 Remark: RTM loci are always physically associated with SUC telomeric loci. The SUC-RTM sequences are located between X and Y' subtelomeric sequences at chromosome ends.; Remark: RTM1 in S. cerevisiae confers resistance to the toxicity of molasses.; Remark: The particular subtelomeric position might explain the SUC-RTM sequence amplification observed in the genome of yeasts used in industrial biomass or ethanol production with molasses as substrate.; Remark: the protein shows also similarity to 7-aminocholesterol resistance protein RTA1 - S. cerevisiae.; Title: similarity to molasses resistency protein Rtm1 - Saccharomyces cerevisiae; See PMID 9211787; See PMID 7672593; uncharacterized protein 2435059 4983340 An08g10260 Aspergillus niger uncharacterized protein XP_059606244.1 2433727 D 5061 CDS An08g10270 4983341 complement(join(2435171..2435246,2435343..2435346,2435800..2442223,2442343..2442504)) VIII 1 NT_166524.1 Remark: the S. cerevisae SPO72 diploids homozygous for the null mutation lack premeitoic DNA synthesis and do not sporulate; these phenotypes are recessive.; Title: similarity to hypothetical sporulation required protein Spo72 - Saccharomyces cerevisiae; See PMID 10029994; uncharacterized protein 2442504 4983341 An08g10270 Aspergillus niger uncharacterized protein XP_059606245.1 2435171 R 5061 CDS An08g10280 4983342 complement(join(2443500..2445040,2445097..2445223)) VIII 1 NT_166524.1 Remark: IDGF, stimulated the proliferation of NIH-Sape-4 cells in an autocrine manner.; Remark: similarity to different adenosine deaminases.; Remark: similarity was found between this factor and atrial gland granule-specific antigen of Aplysia californica.; Title: strong similarity to secretory component IDGF - Sarcophaga peregrina; See PMID 8662793; uncharacterized protein 2445223 4983342 An08g10280 Aspergillus niger uncharacterized protein XP_059606246.1 2443500 R 5061 CDS An08g10300 4983344 join(2447519..2447811,2447879..2449130,2449187..2449441) VIII 1 NT_166524.1 Remark: functionally, cNT1 exhibited the transport characteristics of the nucleoside transport system cit (selective for pyrimidine nucleosides and adenosine) and accepted both 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC) as permeants (Km = 0. 49 and 0. 51 mM, respectively).; Title: strong similarity to concentrative Na+-nucleoside cotransporter cNT1 - Rattus norvegicus; See PMID 10455109; See PMID 8027026; uncharacterized protein 2449441 4983344 An08g10300 Aspergillus niger uncharacterized protein XP_001393134.3 2447519 D 5061 CDS An08g10310 4983345 complement(join(2450522..2450627,2450683..2451015,2451103..2451209)) VIII 1 NT_166524.1 Catalytic activity: ATP + Ubiquitin + Protein lysine = AMP + Pyrophosphate + Protein N-ubiquityllysine.; Remark: UBC11 is the S. cerevisiae gene that is most similar in sequence to E2-C, a ubiquitin carrier protein required for the destruction of mitotic cyclins and proteins that maintain sister chromatid cohesion in animal cells and in Schizosaccharomyces pombe.; Remark: ubiquitin is coupled to protein by a peptide bond between the C-terminal glycine of ubiquitin and epsilon-amino groups of lysine residues in the protein. An intermediate in the reaction contains one ubiquitin residue bound as a thiolester to the enzyme, and a residue of ubiquitin adenylate non-covalently bound to the enzyme.; Title: strong similarity to ubiquitin conjugating enzyme Ubc11 - Saccharomyces cerevisiae; See PMID 9675819; See PMID 10762014; uncharacterized protein 2451209 4983345 An08g10310 Aspergillus niger uncharacterized protein XP_001393135.1 2450522 R 5061 CDS An08g10320 4983346 join(2452444..2452529,2452574..2454122) VIII 1 NT_166524.1 Function: fission yeast chk1 protein kinase is involved in cell-cycle arrest when DNA damage has occurred or when unligated DNA is present. it controls phosphorylation and abundance of pds1 to prevent anaphase entry and also helps prevent mitotic exit.; Remark: coupling of the checkpoint pathways that monitor DNA repair and replication to the control of the cell cycle is essential.; Similarity: the predicted A. niger protein shows strong similarity to checkpoint protein kinase chk1 from S. pombe and from many other eucaryotic species.; Title: strong similarity to checkpoint protein kinase chk1p - Schizosaccharomyces pombe; See PMID 8497322; See PMID 10679396; uncharacterized protein 2454122 4983346 An08g10320 Aspergillus niger uncharacterized protein XP_059606247.1 2452444 D 5061 CDS An08g10330 4983347 join(2454774..2454816,2454899..2456913) VIII 1 NT_166524.1 Title: weak similarity to hepatoma-derived growth factor-related protein HRP-2 - Mus musculus; See PMID 929944; uncharacterized protein 2456913 4983347 An08g10330 Aspergillus niger uncharacterized protein XP_059606248.1 2454774 D 5061 CDS An08g10340 4983348 join(2457744..2458045,2458135..2458579,2458887..2458949) VIII 1 NT_166524.1 Catalytic activity: GTP + 3 H2O = Formate + 2,5-Diamino-6-hydroxy-4-(5'-phosphoribosylamino)-pyrimidin e + Pyrophosphate.; Pathway: riboflavin biosynthesis pathway.; Remark: GTP-cyclohydrolase II forms 2,5-diamino-4-oxo-6-(5'-phosphoribosyl)-amino pyrimidine, a possible intermediate in the biosynthesis of riboflavin.; Remark: GTP-cyclohydrolases catalyse the removal of C-8 atom from GTP as formic acid.; Title: strong similarity to 3,4-dihydroxy-2-butanone 4-phosphate synthase Rib3 - Saccharomyces cerevisiae; See PMID 394766; See PMID 3891906; uncharacterized protein 2458949 4983348 An08g10340 Aspergillus niger uncharacterized protein XP_059606249.1 2457744 D 5061 CDS An08g10350 4983349 complement(2459246..2460124) VIII 1 NT_166524.1 Remark: components of the RNA polymerase II holoenzyme, the general transcription factor TFIID, and the SAGA chromatin modification complex were found to have roles in expression of distinct sets of genes.; Title: strong similarity to beta subunit of transcription initiation factor TFIIE Tfa2 - Saccharomyces cerevisiae; nucleus; See PMID 9545282; See PMID 9845373; See PMID 7961670; uncharacterized protein 2460124 4983349 An08g10350 Aspergillus niger uncharacterized protein XP_001393139.1 2459246 R 5061 CDS An08g10360 4983350 join(2460780..2461071,2461121..2466912) VIII 1 NT_166524.1 Remark: the human TPR protein seems a general constituent of the intranuclear filaments attached to the nucleoplasmic annulus of the nuclear pore complex (NPC) in diverse kinds of vertebrate cells.; Title: strong similarity to nuclear pore complex associated protein TPR - Homo sapiens; See PMID 9024684; See PMID 10827939; uncharacterized protein 2466912 4983350 An08g10360 Aspergillus niger uncharacterized protein XP_001393140.3 2460780 D 5061 CDS An08g10370 4983351 complement(join(2468427..2468892,2468953..2469146)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein SPBP8B7.31 - Schizosaccharomyces pombe; uncharacterized protein 2469146 4983351 An08g10370 Aspergillus niger uncharacterized protein XP_001393141.1 2468427 R 5061 CDS An08g10380 4983352 complement(join(2469642..2470909,2470973..2471591,2471649..2471696,2471769..2471792)) VIII 1 NT_166524.1 Title: weak similarity to retinitis pigmentosa GTPase regulator-like protein RPGR - Takifugu rubripes; See PMID 10932196; uncharacterized protein 2471792 4983352 An08g10380 Aspergillus niger uncharacterized protein XP_001393142.1 2469642 R 5061 CDS An08g10390 4983353 complement(join(2472732..2473617,2473667..2473850,2473911..2474123,2474268..2474272,2474388..2474482,2474529..2475104,2475162..>2475647)) VIII 1 NT_166524.1 Remark: N-terminal truncated orf due to end of contig.; Remark: the protein seems approximately 200 aa to short.; Remark: these helicases have low-specificityand are zinc-dependent; in vitro they show dna-binding.; Title: strong similarity to DNA/RNA helicase Hfm1 -Saccharomyces cerevisiae [truncated ORF]; See PMID 8972578; uncharacterized protein 2475647 4983353 An08g10390 Aspergillus niger uncharacterized protein XP_059606250.1 2472732 R 5061 CDS An08g10400 4983354 complement(join(2478188..2478499,2478549..2478907,2479061..2479523,2479588..2479617,2479724..2479792)) VIII 1 NT_166524.1 Remark: SpUGT S. pombe was expressed in the Golgi membranes of UDP-galactose transporter-deficient Lec8 cells, and complemented the genetic defect of the mutant cells.; Similarity: belongs to the UDP-galactose transporter.; Title: strong similarity to UDP-galactose transport protein SpUGT - Schizosaccharomyces pombe; uncharacterized protein 2479792 4983354 An08g10400 Aspergillus niger uncharacterized protein XP_059604156.1 2478188 R 5061 CDS An08g10410 4983355 complement(2481763..2483994) VIII 1 NT_166524.1 Remark: the protein shows similarity to proteins with different functions and length due to repetitiv sequences.; Title: weak similarity to hypothetical RNA binding protein - Homo sapiens; uncharacterized protein 2483994 4983355 An08g10410 Aspergillus niger uncharacterized protein XP_001393145.1 2481763 R 5061 CDS An08g10420 84591824 join(2485198..2485270,2485616..2485683,2485958..2486071,2486199..2486390) VIII 1 NT_166524.1 hypothetical protein 2486390 84591824 An08g10420 Aspergillus niger hypothetical protein XP_059604157.1 2485198 D 5061 CDS An08g10430 84591825 complement(join(2486596..2486642,2486737..2487007,2487346..2487437,2487515..2487592,2487902..2488037,2488076..2488242,2488337..2488437,2488513..2488550)) VIII 1 NT_166524.1 hypothetical protein 2488550 84591825 An08g10430 Aspergillus niger hypothetical protein XP_059604158.1 2486596 R 5061 CDS An08g10440 4983358 complement(join(2490245..2490742,2490792..2490985,2491033..2491261,2491305..2491538,2491602..2491899,2491948..2492113,2492163..2492442,2492492..2492708,2492771..2492793,2492851..2493060)) VIII 1 NT_166524.1 Remark: in yeast, HOP1 and RED1 are required during meiosis for proper chromosome segregation and the consequent formation of viable spores. HOP1 is associated with the lateral elements of the SC.; Remark: the synaptonemal complex (SC) is a meiosis-specific proteinaceous structure that holds homologous chromosomes close together along their length during the pachytene stage of meiotic prophase. The SC is observed in sexually reproducing fungi, plants and animals and is highly conserved at the cytological level.; Title: similarity to meiosis-specific protein HOP1 -Kluyveromyces lactis; See PMID 10855495; See PMID 10958662; uncharacterized protein 2493060 4983358 An08g10440 Aspergillus niger uncharacterized protein XP_059604159.1 2490245 R 5061 CDS An08g10450 4983359 join(2495628..2495924,2496012..2497225,2497496..2498726,2498777..2498902) VIII 1 NT_166524.1 Remark: Sud1 of fission yeast itself is associated with the ubiquitin pathway in fission yeast and binds to Cdc18 in vivo.; Remark: alternative names sud1.; Remark: in the fission yeast Schizosaccharomyces pombe, S phase is limited to a single round per cell cycle through cyclin-dependent kinase phosphorylation of critical replication factors. evolutionary conservation of the Sud1/CDC4 pathway suggests that phosphorylation-coupled proteolysis may be a general feature of nearly all eukaryotic cell cycles.; Title: similarity to F-box/WD-repeat protein op2p -Schizosaccharomyces pombe; See PMID 9653157; uncharacterized protein 2498902 4983359 An08g10450 Aspergillus niger uncharacterized protein XP_059604160.1 2495628 D 5061 CDS An08g10460 4983360 complement(join(2499471..2499727,2499933..2500342,2500408..2500955)) VIII 1 NT_166524.1 Remark: YsxC is a member of a family of GTP-binding proteins carried by a diverse range of organisms from bacteria to yeasts, plants, and humans.; Remark: there is also similarity to Aquifex aeolicus yihA family member polypeptide sequence patent WO9954474-A2.; Similarity: to translation elongation factor Tu.; Title: similarity to GTP-binding protein ysxC -Bacillus subtilis; See PMID 11073929; uncharacterized protein 2500955 4983360 An08g10460 Aspergillus niger uncharacterized protein XP_001393150.3 2499471 R 5061 CDS An08g10470 4983361 join(2501350..2501418,2501511..2501999) VIII 1 NT_166524.1 Remark: eukaryotic vesicular transport requires the recognition of membranes through specific protein complexes.; Similarity: belongs to the adaptor complexes small subunits family.; Title: strong similarity to clathrin coat assembly protein CLAPS3 - Homo sapiens; See PMID 8697810; See PMID 10229581; uncharacterized protein 2501999 4983361 An08g10470 Aspergillus niger uncharacterized protein XP_001393151.1 2501350 D 5061 CDS An08g10480 4983362 join(2502620..2502622,2502952..2503029,2503102..2503611,2503676..2503876) VIII 1 NT_166524.1 Remark: L7a is the third largest protein in the 60s subunit.; Similarity: belongs to the l7ae family of ribosomal proteins.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L7 - Schizosaccharomyces pombe; cytoplasm; See PMID 9565672; See PMID 11130464; 60S ribosomal protein eL8 2503876 4983362 An08g10480 Aspergillus niger 60S ribosomal protein eL8 XP_001393152.1 2502620 D 5061 CDS An08g10490 4983363 complement(join(2504192..2504344,2504852..2507240,2507311..2507519,2507632..2507688)) VIII 1 NT_166524.1 Remark: shows also similarity to tumor overexpressed protein TOG from Homo sapiens and similar genes from higher eukaryotes which are about the double in size.; Remark: the tagged p93dis1 S. pombe in living cells localizes along cytoplasmic microtubule arrays in interphase and the elongating anaphase spindle in mitosis,but association with the short metaphase spindle microtubules is strikingly reduced. In the spindle, the tagged p93dis1 is enriched at the spindle pole bodies (SPBs).; Title: strong similarity to spindle pole body-associated protein dis1p - Schizosaccharomyces pombe; See PMID 7628693; uncharacterized protein 2507688 4983363 An08g10490 Aspergillus niger uncharacterized protein XP_059604161.1 2504192 R 5061 CDS An08g10500 4983364 complement(join(2508834..2508899,2508929..2508963,2509082..2509137,2509234..2509883)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein EAA62682.1 - Aspergillus nidulans; uncharacterized protein 2509883 4983364 An08g10500 Aspergillus niger uncharacterized protein XP_001393154.3 2508834 R 5061 CDS An08g10510 4983365 complement(join(2510717..2510879,2510932..2511271,2511323..2511693,2511758..2512130,2512237..2512543)) VIII 1 NT_166524.1 Catalytic activity: UDPglucose + D-glucose 6-phosphate = UDP + alpha,alpha'-trehalose 6-phosphate.; Gene-ID: tpsA;tps1; Pathway: starch and sucrose metabolism.; Remark: disruption of tpsA only weakly reduces growth on glucose, and neither influences the glucose induction of a low affinity glucose permease nor interferes with the catabolite repression of a pectinase; it causes reduced heat tolerance of conidia.; Remark: strong similarity to Aspergillus niger trehalose synthase patent WO9824882-A1.; Remark: the difference in the sequences is caused by strain variations or sequencing errors.; Similarity: to other fungal tps1 and to an E. coli enzyme (gene otsa).; cytoplasm; See PMID 9006911; See PMID 11152943; trehalose-6-phosphate synthase subunit 1 tpsA-Aspergillus niger 2512543 tpsA 4983365 tpsA Aspergillus niger trehalose-6-phosphate synthase subunit 1 tpsA-Aspergillus niger XP_001393155.1 2510717 R 5061 CDS An08g10520 4983366 complement(join(2514682..2514702,2515033..2515394,2515449..2515808,2515871..2515883,2515950..2516033)) VIII 1 NT_166524.1 Remark: putative hydrolase with unknown specificity.; Remark: strong similarity to human prostate tumor EST fragment derived protein #67 patent DE19820190-A1.; Title: strong similarity to human prostate tumor EST fragment derived protein #67 from patent DE19820190-A1 -Homo sapiens; uncharacterized protein 2516033 4983366 An08g10520 Aspergillus niger uncharacterized protein XP_001393156.3 2514682 R 5061 CDS An08g10530 4983367 complement(join(2517127..2517387,2517450..2518795,2518854..2519452,2519555..2519574,2519664..2519741,2519838..2519855,2519982..2519993)) VIII 1 NT_166524.1 Catalytic activity: citrate = isocitrate.; Pathway: citrate cycle (TCA cycle); glyoxylate and dicarboxylate metabolism; reductive carboxylate cycle (CO2 fixation).; Remark: aconitase has an active (4fe-4s) and an inactive (3fe-4s) forms. the active (4fe-4s) cluster is part of the catalytic site that interconverts citrate,cis-aconitase, and isocitrate.; Remark: an iron-sulfur protein. cis-Aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3-tricarboxylate. Also converts isocitrate into cis-aconitate.; Similarity: belongs to the aconitase/ipm isomerase family.; Title: strong similarity to mitochondrial aconitate hydratase Aco1 - Saccharomyces cerevisiae; See PMID 10490611; See PMID 1972545; uncharacterized protein 2519993 4983367 An08g10530 Aspergillus niger uncharacterized protein XP_001393157.3 2517127 R 5061 CDS An08g10540 4983368 join(2520459..2520511,2520830..2520902,2520959..2521387,2521501..2521667,2521757..2521877) VIII 1 NT_166524.1 Title: similarity to hypothetical protein CAD60750.1 - Podospora anserina; uncharacterized protein 2521877 4983368 An08g10540 Aspergillus niger uncharacterized protein XP_059604162.1 2520459 D 5061 CDS An08g10550 4983369 complement(join(2522476..2522815,2522899..2523238,2523295..2523466)) VIII 1 NT_166524.1 Remark: the human carnitine/acylcarnitine translocase (CACT) transports acylcarnitines into mitochondria in exchange for free carnitine and it is,therefore, essential for the fatty acid beta-oxidation pathway.; Title: strong similarity to carnitine/acylcarnitine translocase CACT - Homo sapiens; See PMID 9837782; uncharacterized protein 2523466 4983369 An08g10550 Aspergillus niger uncharacterized protein XP_001393159.3 2522476 R 5061 CDS An08g10560 4983370 join(2523773..2523885,2524281..2524953,2525009..2525092,2525143..2525266,2525313..2526859) VIII 1 NT_166524.1 Remark: characterization of the Neurospora crassa mus-25 mutant suggests that it is defective in recombination repair and belongs to the uvs-6 epistasis group. It shows a high sensitivity to the alkylating agents methyl methanesulfonate (MMS) and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), but not to UV radiation.; Remark: the prdicted ORF shows also strong similarity to human RAD54 N-terminal peptide patent EP844305-A2.; Similarity: belongs to the snf2/rad54 helicase family.; Title: strong similarity to Rad54 homolog mus-25 -Neurospora crassa; See PMID 11016845; uncharacterized protein 2526859 4983370 An08g10560 Aspergillus niger uncharacterized protein XP_059604163.1 2523773 D 5061 CDS An08g10570 4983371 join(2527590..2527657,2527734..2527896,2527956..2528126,2528186..2528873,2528927..2529136,2529257..2529711,2529765..2529869,2529922..2530040,2530142..2530180,2530259..2530936,2530996..2530999,2531218..2531244) VIII 1 NT_166524.1 Title: strong similarity to hypothetical membrane protein YLR386w - Saccharomyces cerevisiae; uncharacterized protein 2531244 4983371 An08g10570 Aspergillus niger uncharacterized protein XP_059604164.1 2527590 D 5061 CDS An08g10580 10098335 complement(join(2531920..2532160,2532236..2532330)) VIII 1 NT_166524.1 hypothetical protein 2532330 10098335 An08g10580 Aspergillus niger hypothetical protein XP_059604165.1 2531920 R 5061 CDS An08g10590 84591826 join(2532359..2532376,2532449..2532541,2532674..2532739,2532823..2532900,2532958..2533018,2533057..2533188,2533249..2533298,2533811..2533966,2534073..2534171) VIII 1 NT_166524.1 hypothetical protein 2534171 84591826 An08g10590 Aspergillus niger hypothetical protein XP_059604166.1 2532359 D 5061 CDS An08g10600 4983374 complement(join(2534355..2534729,2534793..2535839,2535892..2536160,2536210..2536324,2536378..2536437,2536499..2536876)) VIII 1 NT_166524.1 Remark: Yeast cells lacking a functional ATM1 gene have an unstable mitochondrial genome and have white mitochondria that completely lack cytochromes. Atm1p is the first mitochondrial member of the ABC family to be identified and the only eukaryotic ABC transporter that has been shown to be necessary for normal cellular growth.; Similarity: belongs to the ATP-binding transport protein family (ABC transporters). MDR subfamily.; Title: strong similarity to ABC transporter Atm1 -Saccharomyces cerevisiae; See PMID 7828591; See PMID 9428742; uncharacterized protein 2536876 4983374 An08g10600 Aspergillus niger uncharacterized protein XP_059604167.1 2534355 R 5061 CDS An08g10610 4983375 join(2537941..2538148,2538392..2538522,2538773..2538891,2538943..2539162,2539213..2539518,2539580..2539600,2539648..2539680) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein EAA59931.1 - Aspergillus nidulans; uncharacterized protein 2539680 4983375 An08g10610 Aspergillus niger uncharacterized protein XP_059604168.1 2537941 D 5061 CDS An08g10620 10098336 join(2540142..2540478,2540540..2540547) VIII 1 NT_166524.1 hypothetical protein 2540547 10098336 An08g10620 Aspergillus niger hypothetical protein XP_059604169.1 2540142 D 5061 CDS An08g10630 84591827 complement(join(2540824..2541274,2541488..2541594)) VIII 1 NT_166524.1 hypothetical protein 2541594 84591827 An08g10630 Aspergillus niger hypothetical protein XP_059604170.1 2540824 R 5061 CDS An08g10640 4983378 complement(join(2542269..2543843,2543893..2544302,2544356..2544626)) VIII 1 NT_166524.1 Remark: Xkid is responsible for the polar ejection forces acting on chromosome arms.; Remark: microtubule-associated motor proteins are thought to be involved in spindle formation and chromosome movements in mitosis/meiosis.; Title: strong similarity to kinesin-like DNA binding protein Xkid - Xenopus laevis; See PMID 8599929; See PMID 10966105; uncharacterized protein 2544626 4983378 An08g10640 Aspergillus niger uncharacterized protein XP_001393168.1 2542269 R 5061 CDS An08g10650 4983379 join(2546140..2546676,2546733..2548379,2548436..2549011) VIII 1 NT_166524.1 Remark: COPII is composed of at least five proteins: the sec23/24 complex, the sec13/31 complex and sar1.; Remark: component of the COPII coat, that covers er-derived vesicles involved in transport from the endoplasmic reticulum to the golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory,plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex.; Similarity: belongs to the sec23/sec24 family. sec24 subfamily.; Title: strong similarity to transport protein Sec24 - Saccharomyces cerevisiae; intracellular transport vesicles; See PMID 10712514; See PMID 10753972; uncharacterized protein 2549011 4983379 An08g10650 Aspergillus niger uncharacterized protein XP_001393169.1 2546140 D 5061 CDS An08g10660 84591828 join(2549809..2549846,2550090..2550129,2550213..2550246,2550318..2550389,2550474..2550506,2550758..2551061,2551524..2551560) VIII 1 NT_166524.1 hypothetical protein 2551560 84591828 An08g10660 Aspergillus niger hypothetical protein XP_059604171.1 2549809 D 5061 CDS An08g10670 4983381 join(2552248..2552357,2552413..2552608,2552658..2553387,2553435..2553463) VIII 1 NT_166524.1 Catalytic activity: ATP + a protein = ADP + a phosphoprotein.; Remark: MAP kinases have been established to be key regulators of cellular signal transduction systems and are conserved from baker's yeast to human beings.; Similarity: belongs to the serine/threonine protein kinase family.; Title: strong similarity to mitogen-activated protein kinase FsMAPK - Fusarium solani; deleted EC_number 2.7.1.37; See PMID 9305760; See PMID 10600495; uncharacterized protein 2553463 4983381 An08g10670 Aspergillus niger uncharacterized protein XP_001393171.1 2552248 D 5061 CDS An08g10680 4983382 complement(join(2553833..2554527,2554595..2554907)) VIII 1 NT_166524.1 Catalytic activity: hydroxymethylbilane = uroporphyrinogen III + H2O.; Pathway: porphyrin and chlorophyll metabolism; fourth step in porphyrin biosynthesis by the shemin pathway. involved in heme biosynthesis.; Remark: a hem4 delta disruption mutation was constructed which had phenotypes identical to the cyt mutation. Biochemical analysis confirmed the absence of uroporphyrinogen III synthase activity in both hem4 delta and cyt mutant strains.; Similarity: to uroporphyrinogen-III synthase from different organisms.; Title: similarity to uroporphyrinogen-III synthase Hem4 - Saccharomyces cerevisiae; See PMID 2834088; See PMID 7597845; uncharacterized protein 2554907 4983382 An08g10680 Aspergillus niger uncharacterized protein XP_001393172.1 2553833 R 5061 CDS An08g10690 4983383 complement(join(2555103..2555201,2555252..2555587,2555635..2555793,2555841..2555982,2556034..2556125,2556183..2556277,2556328..2556390,2556457..2556470,2556528..2556646)) VIII 1 NT_166524.1 Catalytic activity: NADH + ubiquinone = NAD+ + ubiquinol.; Pathway: oxidative phosphorylation, respiratory chain complex I.; Phenotype: the mutant complex lacking the 40 kD subunit is not capable of reducing ubiquinone.; Title: strong similarity to 40 kD subunit of NADH-ubiquinone reductase NUO-40 - Neurospora crassa; localisation:mitochondrion; See PMID 10497022; See PMID 1825202; uncharacterized protein 2556646 4983383 An08g10690 Aspergillus niger uncharacterized protein XP_001393173.3 2555103 R 5061 CDS An08g10700 4983384 complement(join(2557249..2557770,2557842..2558013,2558067..2558113)) VIII 1 NT_166524.1 Title: similarity to hypothetical methyltransferase - Schizosaccharomyces pombe; uncharacterized protein 2558113 4983384 An08g10700 Aspergillus niger uncharacterized protein XP_001393174.1 2557249 R 5061 CDS An08g10710 4983385 join(2558688..2558955,2559025..2559260,2559319..2559960) VIII 1 NT_166524.1 Function: the S. cerevisiae homolog Rpn9p is subunit of the 19S proteasome regulatory particle.; Similarity: strong similarity to Human 26S proteasome sequence patent JP11032774-A, and same sequence Human secreted protein clone yj29_1 protein sequence SEQ ID NO:80 patent WO9958642-A2.; Title: strong similarity to proteasome 19S regulatory particle subunit Rpn9 - Saccharomyces cerevisiae; uncharacterized protein 2559960 4983385 An08g10710 Aspergillus niger uncharacterized protein XP_001393175.1 2558688 D 5061 CDS An08g10720 4983386 complement(join(2560040..2560067,2560124..2560159,2560400..2560821,2560881..2561749,2561815..2562053,2562144..2562435,2562602..2562614)) VIII 1 NT_166524.1 Remark: Gaa1p S. cerevisiae is required for a terminal step of GPI anchor attachment and could be part of the putative GPI:protein transamidase.; Remark: alternative names are Gaa1p, YLR088w.; Remark: anchoring of proteins to membranes by glycosylphosphatidylinositols (GPIs) is ubiquitous among all eukaryotes and heavily used by parasitic protozoa. GPI is synthesized and transferred en bloc to form GPI-anchored proteins. The key enzyme in this process is a putative GPI:protein transamidase that would cleave a peptide bond near the COOH terminus of the protein and attach the GPI by an amide linkage.; Title: strong similarity to glycosylphosphatidylinositol anchor attachment protein End2 - Saccharomyces cerevisiae; See PMID 7730400; uncharacterized protein 2562614 4983386 An08g10720 Aspergillus niger uncharacterized protein XP_059604172.1 2560040 R 5061 CDS An08g10730 4983387 complement(join(2562876..2563103,2563140..2563378,2563433..2563456,2563585..2563722,2563784..2563976)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein SPAC19B12.06c - Schizosaccharomyces pombe; uncharacterized protein 2563976 4983387 An08g10730 Aspergillus niger uncharacterized protein XP_059604173.1 2562876 R 5061 CDS An08g10740 4983388 complement(join(2564718..2564920,2564983..2565100,2565165..2565493,2565563..2565650)) VIII 1 NT_166524.1 Function: the ZmGnsN3 glucanase of Z. may is e. g. believed to be useful as hydrolase in cell wall elongation or expansion for plant defense against pathogens and stress.; Similarity: the ORF shows strong similarity to the hypothetical protein YAL049c of S. cerevisiae.; Title: strong similarity to ZmGnsN3 glucanase from patent WO200073470-A2 - Zea mays; uncharacterized protein 2565650 4983388 An08g10740 Aspergillus niger uncharacterized protein XP_001393178.1 2564718 R 5061 CDS An08g10750 4983389 complement(join(2566638..2566823,2566885..2567586,2567642..2567667,2567762..2568869)) VIII 1 NT_166524.1 Remark: SPBC3B8. 06 of S. pombe is possibly involved in RNA binding and is similar to the probable membrane protein YCR062w of S. cerevisiae, which is only 120 amino acids long.; Similarity: the ORF overlaps with A. niger ESTs an_2557 (EMBLEST:BE759690), an_2482 (EMBLEST:BE759628) and an_1914 (EMBLEST:BE760577).; Similarity: the predicted ORF is 143 amino acids longer at its N-terminus than SPBC3B8. 06 of S. pombe.; Title: strong similarity to hypothetical protein SPBC3B8.06 - Schizosaccharomyces pombe; uncharacterized protein 2568869 4983389 An08g10750 Aspergillus niger uncharacterized protein XP_059604174.1 2566638 R 5061 CDS An08g10760 4983390 2569859..2571220 VIII 1 NT_166524.1 Function: autotransporters are implicated as important or putative virulence factors in many Gram-negative pathogens.; Similarity: the ORF shows similarity to ice nucleation proteins from some bacteria, which is necessary to stimulate ice growth at temperatures below 0 degrees.; Title: similarity to hypothetical autotransporter protein yapE - Yersinia pestis; See PMID 8224607; See PMID 9778731; uncharacterized protein 2571220 4983390 An08g10760 Aspergillus niger uncharacterized protein XP_001393180.1 2569859 D 5061 CDS An08g10770 84591829 join(2571617..2572142,2572189..2572263,2572336..2572508) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein CAD70330.1 - Neurospora crassa; uncharacterized protein 2572508 84591829 An08g10770 Aspergillus niger uncharacterized protein XP_059604175.1 2571617 D 5061 CDS An08g10780 4983392 join(2572709..2572774,2572827..2572887,2572961..2573052,2573113..2573324,2573380..2573467,2573514..2573627,2573710..2573722,2573771..2573906,2573955..2574045,2574102..2574516,2574576..2574613) VIII 1 NT_166524.1 Similarity: the predicted ORF is 66 amino acids shorter than the hypothetical protein T16K5. 230 of A. thaliana.; Title: strong similarity to hypothetical protein T16K5.230 - Arabidopsis thaliana; uncharacterized protein 2574613 4983392 An08g10780 Aspergillus niger uncharacterized protein XP_059604176.1 2572709 D 5061 CDS An08g10790 4983393 join(2575252..2575420,2575473..2575607,2575897..2576999) VIII 1 NT_166524.1 Function: hol1 S. cerevisiae is involved in the uptake of histidinol, the biosynthetic precursor to histidine and of several cations.; Phenotype: additional hol1 mutations in S. cerevisiae histidine auxotrophs can confer a novel,non-selective cation transport pattern.; Phenotype: the null mutant of hol1 in S. cerevisiae is viable, but unable to take up histidinol or Na+.; Remark: hol1 is also called YNR055C or N3494 and belongs to the major facilitator family (drug resistance translocase family).; Similarity: the ORF shows similarity to several major facilitator family multi-drug resistance proteins from different species and with various substrate specificities.; Title: similarity to multidrug resistance protein Hol1 - Saccharomyces cerevisiae; See PMID 8955402; See PMID 2405251; uncharacterized protein 2576999 4983393 An08g10790 Aspergillus niger uncharacterized protein XP_059604177.1 2575252 D 5061 CDS An08g10800 4983394 complement(join(2577506..2577783,2577840..2579499,2579560..2579619)) VIII 1 NT_166524.1 Catalytic activity: lox of N. crassa converts an L-amino acid + H(2)O + O(2) <=> a 2-oxo acid + NH(3) + H(2)O(2).; Function: in lower eukaryotes such as aspergillus the main role of amine oxidases is to provide a source of ammonium.; Induction: the addition of D-phenylalanine to starved cultures of N. crassa leads to de novo synthesis of L-amino-acid oxidase.; Remark: lox of N. crassa is also called lao.; Title: strong similarity to L-amino-acid oxidase lox - Neurospora crassa; See PMID 2145270; uncharacterized protein 2579619 4983394 An08g10800 Aspergillus niger uncharacterized protein XP_059604178.1 2577506 R 5061 CDS An08g10810 4983395 complement(2580227..2582038) VIII 1 NT_166524.1 Similarity: only the N-terminal region of the ORF shows similarity to some hypothetical proteins.; Similarity: the ORF is 278 amino acids longer than LRP16 of H. sapiens.; Title: strong similarity to hypothetical low density lipoprotein LRP16 - Homo sapiens; uncharacterized protein 2582038 4983395 An08g10810 Aspergillus niger uncharacterized protein XP_001393185.1 2580227 R 5061 CDS An08g10820 4983396 join(2583308..2583641,2583703..2584838) VIII 1 NT_166524.1 Catalytic activity: NAD(+)-dependent aldehyde dehydrogenases convert an aldehyde + NAD(+) + H(2)O <=> an acid + NADH.; Function: iad1 of U. maydis converts indole-3-acetaldehyde to indole-3-acetic acid in the presence of NAD(+).; Induction: expression of iad1 from U. maydis was strongly induced during growth on ethanol while under these conditions iad1-null mutants were unable to grow.; Phenotype: the ability of iad1 from U. maydis to convert IndCH2CH2O to IndCH2COOH was at least 100-fold reduced in iad1-null mutants grown in medium with glucose as carbon source.; Similarity: the ORF shows similarity to NAD(+)-dependent aldehyde dehydrogenases, which are involved in diverse metabolic pathways.; Title: strong similarity to indole-3-acetaldehyde dehydrogenase iad1 - Ustilago maydis; uncharacterized protein 2584838 4983396 An08g10820 Aspergillus niger uncharacterized protein XP_001393186.1 2583308 D 5061 CDS An08g10830 4983397 complement(join(2585116..2586661,2586730..2586881)) VIII 1 NT_166524.1 Catalytic activity: dimethylallyltransferases (EC 2. 5. 1. 1) convert dimethylallyl diphosphate + isopentenyl diphosphate <=> diphosphate + geranyl diphosphate.; Catalytic activity: geranylgeranyl pyrophosphate synthases convert trans-trans-farnesyl diphosphate + isopentenyl diphosphate <=> diphosphate + geranylgeranyl diphosphate.; Catalytic activity: geranyltranstransferases (EC 2. 5. 1. 10) convert geranyl diphosphate + isopentenyl diphosphate <=> diphosphate + trans,trans-farnesyl diphosphate.; Function: geranylgeranyl diphosphate synthase is a key enzyme in isoprenoid biosynthesis.; Function: ggpps of G. fujikuroi has three catalytic activities, of EC 2. 5. 1. 29, EC 2. 5. 1. 1 and EC 2. 5. 1. 10.; Remark: ggpps of G. fujikuroi is also called ggs.; Similarity: the ORF is 129 amino acids longer at its N-terminus than ggpps of G. fujikuroi and is also longer than other geranylgeranyl pyrophosphate synthase homologues from different species.; Title: strong similarity to geranylgeranyl pyrophosphate synthase GGPPS - Gibberella fujikuroi; See PMID 9230902; uncharacterized protein 2586881 4983397 An08g10830 Aspergillus niger uncharacterized protein XP_001393187.3 2585116 R 5061 CDS An08g10840 84591830 join(2587685..2587687,2587778..2587896,2587973..2588111,2588205..2588264,2588587..2588783,2588977..2589162,2589254..2589386,2589476..2589628) VIII 1 NT_166524.1 hypothetical protein 2589628 84591830 An08g10840 Aspergillus niger hypothetical protein XP_059604179.1 2587685 D 5061 CDS An08g10860 4983400 complement(join(2590725..2591159,2591212..2591327,2591395..2591883,2591942..2596919)) VIII 1 NT_166524.1 Catalytic activity: fatty acid synthases convert acetyl-CoA + N malonyl-CoA + 2N NADPH <=> a long-chain fatty acid + (N+1) CoA + N CO(2) + 2N NADP(+).; Catalytic activity: fatty-acyl-CoA synthases convert acetyl-CoA + N malonyl-CoA + 2 NADH + 2 NADPH <=> a long-chain acyl-CoA + N CoA + N CO(2) + N NAD(+) + N NADP(+).; Similarity: the ORF also shows strong similarity to fatty-acyl-CoA synthase (EC 2. 3. 1. 86) beta chain from yeast species.; Title: strong similarity to fatty acid synthase beta subunit fasB - Aspergillus nidulans; uncharacterized protein 2596919 4983400 An08g10860 Aspergillus niger uncharacterized protein XP_059604180.1 2590725 R 5061 CDS An08g10870 4983401 join(2597305..2597662,2597722..2598842) VIII 1 NT_166524.1 Function: prpD of S. typhimurium is involved in propionate catabolism, an operon is constituted by the prpBCDE genes.; Remark: in contrast to prpD of S. typhimurium no membrane localization is predicted for the ORF.; Title: strong similarity to 2-methylcitrate dehydratase PrpD - Salmonella typhimurium; See PMID 9006051; uncharacterized protein 2598842 4983401 An08g10870 Aspergillus niger uncharacterized protein XP_001393190.1 2597305 D 5061 CDS An08g10880 4983402 complement(join(2599077..2599581,2599642..2600120,2600174..2600332,2600386..2601226,2601317..2601519)) VIII 1 NT_166524.1 Function: lovastatin biosynthesis gene cluster ORF13 of A. terreus is a putative transcription regulator involved in the biosynthesis of polyketides, ubiquitous products of secondary metabolism in microorganisms.; Similarity: the ORF shows similarity to several transcriptional regulators from different species.; Title: strong similarity to regulator protein of lovastatin biosynthesis gene cluster encoded by ORF13 -Aspergillus terreus; See PMID 10334994; uncharacterized protein 2601519 4983402 An08g10880 Aspergillus niger uncharacterized protein XP_059604181.1 2599077 R 5061 CDS An08g10890 84591831 complement(join(2601886..2602002,2602104..2602190,2602230..2602341,2602483..2602499)) VIII 1 NT_166524.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght of only 110 amino acids.; Title: questionable ORF; uncharacterized protein 2602499 84591831 An08g10890 Aspergillus niger uncharacterized protein XP_059604182.1 2601886 R 5061 CDS An08g10900 84591832 join(2602557..2602738,2602833..2602932,2602986..2603222,2603269..2603328) VIII 1 NT_166524.1 hypothetical protein 2603328 84591832 An08g10900 Aspergillus niger hypothetical protein XP_059604183.1 2602557 D 5061 CDS An08g10910 84591833 join(2604145..2604234,2604516..2604613,2604698..2604866) VIII 1 NT_166524.1 Remark: the predicted ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF; uncharacterized protein 2604866 84591833 An08g10910 Aspergillus niger uncharacterized protein XP_059604184.1 2604145 D 5061 CDS An08g10920 4983406 complement(join(2604982..2605008,2605090..2605177,2605238..2605301,2605357..2605439,2605499..2606254,2606313..2606510,2606572..2606843)) VIII 1 NT_166524.1 Catalytic activity: citrate synthase YKPSCA of P. aeruginosa catalyses the reaction citrate + CoA <=> acetyl-CoA + H(2)O + oxaloacetate.; Function: citrate synthase is the enzyme that catalyzes the synthesis of citrate from oxaloacetate and acetyl-CoA in an aldol condensation.; Induction: the activity of citrate synthase YKPSCA from P. aeruginosa is allosteric regulated by NADH.; Similarity: the predicted ORF shows similarity to citrate synthases from several species.; Title: strong similarity to citrate synthase YKPSCA - Pseudomonas aeruginosa; uncharacterized protein 2606843 4983406 An08g10920 Aspergillus niger uncharacterized protein XP_059604185.1 2604982 R 5061 CDS An08g10930 4983407 join(2607288..2607370,2607428..2607454,2607506..2607942,2607996..2612707,2612761..2612889) VIII 1 NT_166524.1 Catalytic activity: fatty-acid synthases convert acetyl-CoA + N-malonyl-CoA + 2N NADPH = long chain fatty-acid + (N+1)CoA + N CO(2) + 2N NADP(+).; Function: fatty-acid synthases function in the synthesis of long-chain fatty acids from acety-CoA,malonyl-CoA and NADPH.; Remark: fas2 of S. cerevisiae is a multifunctional enzyme with fatty-acyl-CoA synthase,3-oxoacyl-[acyl-carrier protein] reductase and 3-oxoacyl-[acyl-carrier protein] synthase activity.; Remark: fas2 of S. cerevisiae is also called YPL231w.; Similarity: the predicted ORF shows similarity to fatty-acid synthases from several species.; Title: strong similarity to fatty acid synthase alpha subunit Fas2 - Saccharomyces cerevisiae; See PMID 8962148; uncharacterized protein 2612889 4983407 An08g10930 Aspergillus niger uncharacterized protein XP_001393196.1 2607288 D 5061 CDS An08g10940 84591834 join(2613469..2613507,2613560..2613743,2613754..2613936,2614067..2614392) VIII 1 NT_166524.1 Function: nrgA (nifA-regulated gene) of B. japonicum is probably involved in nitrogen fixation under anaerobic conditions.; Induction: nrgA (nifA-regulated gene) of B. japonicum is controlled by the transcriptional regulatory protein nifA.; Title: weak similarity to hypothetical N-acetyltransferase nrgA - Bradyrhizobium japonicum; See PMID 10692350; uncharacterized protein 2614392 84591834 An08g10940 Aspergillus niger uncharacterized protein XP_059604186.1 2613469 D 5061 CDS An08g10950 4983409 join(2614997..2615039,2615165..2615751) VIII 1 NT_166524.1 hypothetical protein 2615751 4983409 An08g10950 Aspergillus niger hypothetical protein XP_059604187.1 2614997 D 5061 CDS An08g10960 84591835 complement(join(2615836..2615898,2615988..2616091,2616124..2616252,2616346..2616495,2616551..2616644,2616727..2616764,2616853..2616952,2617138..2617311)) VIII 1 NT_166524.1 hypothetical protein 2617311 84591835 An08g10960 Aspergillus niger hypothetical protein XP_059604188.1 2615836 R 5061 CDS An08g10970 4983411 complement(join(2617857..2618720,2618778..2619095,2619157..2619271,2619331..2619393,2619453..2619532,2619606..2619620)) VIII 1 NT_166524.1 Function: flr1 of S. cerevisiae is a multi-drug resistance transporter conferring resistance to several fungicide drugs, e. g. benomyl.; Induction: the expression of flr1 in S. cerevisiae in drug-treated cells is under the control of the transcriptional regulators pdr3p and yap1.; Remark: a splice site was detected upstream of the START codon.; Remark: flr1 of S. cerevisiae is also called YBR008C or YBR0120.; Similarity: the predicted ORF shows similarity to several transporters but also to PATENTPROT:W14439, a protein involved in cephalosporin C biosynthesis.; Title: strong similarity to fluconazole resistance transporter Flr1 - Saccharomyces cerevisiae; plasma membrane; See PMID 10102370; See PMID 10572257; See PMID 11056165; uncharacterized protein 2619620 4983411 An08g10970 Aspergillus niger uncharacterized protein XP_001393200.1 2617857 R 5061 CDS An08g10980 4983412 complement(join(2620335..2620937,2620994..2621378,2621436..2621610,2621665..2622056,2622114..2622765,2622837..2622987)) VIII 1 NT_166524.1 Function: the facB gene of Aspergillus nidulans encodes a DNA binding transcriptional activator required for growth on acetate as sole carbon source.; Phenotype: facB recessive loss of function mutants in A. nidulans are deficient in acetate induction of acetyl-CoA synthase, isocitrate lyase, malate synthase,acetamidase, and NADP-isocitrate dehydrogenase.; Remark: facB of A. nidulans is analogous to the A. niger acuB gene.; Title: strong similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; See PMID 9197408; See PMID 10483720; uncharacterized protein 2622987 4983412 An08g10980 Aspergillus niger uncharacterized protein XP_059604189.1 2620335 R 5061 CDS An08g10990 4983413 complement(join(2623828..2623942,2624055..2624153,2624212..2624477,2624541..2624796,2624856..2624998)) VIII 1 NT_166524.1 Catalytic activity: dienelactone hydrolases convert 4-carboxymethylenebut-2-en-4-olide + H(2)O <=> 4 oxohex-2-enedioate.; Function: dienelactone hydrolases are involved in phenylalanine metabolism and 1,4-dichlorobenzene degradation by facilitating the ring cleavage of the cyclic ester.; Remark: dienelactone hydrolases are also called carboxymethylenebutenolidases or maleylacetate enol-lactonases.; Similarity: the predicted ORF overlaps with A. niger ESTs EMBLEST BE759260, EMBLEST:BE759445, EMBLEST:BE759443,EMBLEST:BE759448 and EMBLEST:BE759416.; Similarity: the predicted ORF shows homology to dienelactone hydrolases from several species.; Title: similarity to dienelactone hydrolase clcD -Rhodococcus opacus; See PMID 8497485; See PMID 9495745; uncharacterized protein 2624998 4983413 An08g10990 Aspergillus niger uncharacterized protein XP_059604190.1 2623828 R 5061 CDS An08g11000 84591836 join(2625443..2625635,2625668..2625753,2625823..2626002) VIII 1 NT_166524.1 Similarity: the predicted ORF shows similarity to the A. niger xlnR gene (T50875), which encodes the regulator of the xylanolytic pathway (PATENTPROT:W08586).; Similarity: the predicted ORF shows similarity to the DNA binding domain of several GAL4-type zinc cluster proteins.; hypothetical protein 2626002 84591836 An08g11000 Aspergillus niger hypothetical protein XP_059604191.1 2625443 D 5061 CDS An08g11010 4983415 join(2626723..2626891,2626957..2627350,2627404..2627557) VIII 1 NT_166524.1 Title: similarity to hypothetical protein encoded by An12g05730 - Aspergillus niger; uncharacterized protein 2627557 4983415 An08g11010 Aspergillus niger uncharacterized protein XP_059604192.1 2626723 D 5061 CDS An08g11020 84591837 join(2627787..2627820,2627883..2627985,2628073..2628193,2628262..2628367,2628478..2628667,2628722..2628827,2628883..2629065) VIII 1 NT_166524.1 hypothetical protein 2629065 84591837 An08g11020 Aspergillus niger hypothetical protein XP_059604193.1 2627787 D 5061 CDS An08g11030 4983417 join(2629304..2630084,2630149..2630266,2630328..2630432,2630492..2630927) VIII 1 NT_166524.1 Catalytic activity: acid phosphatases convert an orthophosphoric monoester + H(2)O <=> an alcohol + phosphate.; Catalytic activity: phytases convert myo-inositol hexakisphosphate + H(2)O <=> D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate.; Function: acid phosphatases in A. niger are involved in the autolysis of mycelia by phosphatase activities as well as intracellular reactions, e. g. the riboflavin metabolism/inositol phosphate metabolism.; Gene-ID: phyB;aph; Remark: A. awamori strains carry several copies of acid phosphatase genes demonstrating the importance for elevated enzyme activities.; Similarity: 14 to 15 amino acids of the predicted ORF differ from the published sequences of the A. niger proteins phyB and aph.; Similarity: the ORF shares strong homologies with EMBL entries EMBL:ANPHYB (A. niger phytase (phyB) gene) and EMBL:AN25AP (A. niger var awamori pH 2. 5 optimum acid phosphatase (aph) gene).; Similarity: the predicted ORF shows strong similarity to entries in the patent database PATENTPROT:R46235 and PATENTPROT:R46791 as well as PATENTDNA:Q58121 and PATENTDNA:Q56945, which concern A. niger pH 2. 5 acid phosphatase.; See PMID 8224894; See PMID 8865587; See PMID 10329192; acid phosphatase aph, 3-phytase phyB-Aspergillus niger 2630927 phyB 4983417 phyB Aspergillus niger acid phosphatase aph, 3-phytase phyB-Aspergillus niger XP_001393206.1 2629304 D 5061 CDS An08g11040 4983418 complement(join(2631711..2632090,2632146..2632322,2632382..2633075,2633145..2633264)) VIII 1 NT_166524.1 Complex: the interaction of ZPR1 with eEF-1alpha contributes to normal cellular proliferation.; Function: loss of ZPR1 in S. pombe causes disruption of nucleolar function, including preribosomal RNA expression.; Localization: the zinc finger protein ZPR1 of different organisms translocates from the cytoplasm to the nucleus after treatment of cells with mitogens, and accumulates in the nucleolus of proliferating cells.; Phenotype: ZPR1 of different organisms is essential for cell viability.; Similarity: A. niger EST EMBLEST:BE758797 contains exon1 and part of exon 2 of the predicted gene.; Title: strong similarity to zinc-finger protein zpr1p - Schizosaccharomyces pombe; See PMID 9763455; See PMID 9852145; uncharacterized protein 2633264 4983418 An08g11040 Aspergillus niger uncharacterized protein XP_001393207.1 2631711 R 5061 CDS An08g11060 4983420 2634649..2635470 VIII 1 NT_166524.1 Similarity: the similarity to A. thaliana T29A15. 10 and other proteins is mainly due to the low complexity region located towards the C-terminus of the predicted protein.; Title: weak similarity to hypothetical protein T29A15.10 - Arabidopsis thaliana; uncharacterized protein 2635470 4983420 An08g11060 Aspergillus niger uncharacterized protein XP_001393208.1 2634649 D 5061 CDS An08g11070 4983421 complement(2635966..2637735) VIII 1 NT_166524.1 Catalytic activity: hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides.; Gene-ID: suc1; Remark: a gene similar, but not identical to suc1 was patented as A. niger beta-fructofuranosidase under patentnumber WO9734004-A1.; Similarity: belongs to family 32 of glycosyl hydrolases.; See PMID 8358833; beta-fructofuranosidase precursor suc1-Aspergillus niger 2637735 suc1 4983421 suc1 Aspergillus niger beta-fructofuranosidase precursor suc1-Aspergillus niger XP_001393209.3 2635966 R 5061 CDS An08g11080 84591838 join(2638298..2638462,2638537..2638593,2638690..2638774,2639054..2639193) VIII 1 NT_166524.1 Remark: with the available literature information it is not possible to understand if the cloned suc1 gene is a genomic DNA or a cDNA; in the case it is a genomic DNA the data are not conflicting with the existence of the predicted ORF An08g11080; in the case the molecule is a cDNA, An08g11080 lies on the 5'UTR of suc1, therefore must be considered very questionable.; Similarity: at the DNA level, the predicted ORF mainly corresponds to a fragment of the A. niger beta-D-fructofuranosidase (suc1) gene, which is identical to ORF An08g11070.; Title: questionable ORF; uncharacterized protein 2639193 84591838 An08g11080 Aspergillus niger uncharacterized protein XP_059604194.1 2638298 D 5061 CDS An08g11090 84591839 complement(join(2639235..2639310,2639431..2639519,2639573..2639614)) VIII 1 NT_166524.1 Remark: with the available literature information it is not possible to understand if the cloned suc1 gene is a genomic DNA or a cDNA; in the case it is a genomic DNA the data are not conflicting with the existence of the predicted ORF An08g11090; in the case the molecule is a cDNA, An08g11090 lies on the 5'UTR of suc1, therefore must be considered very questionable.; Similarity: a small fragment of the predicted ORF shows local identity to a fragment of the A. niger beta-D-fructofuranosidase (suc1) gene, which perfectly corresponds to ORF An08g11070.; Title: questionable ORF; uncharacterized protein 2639614 84591839 An08g11090 Aspergillus niger uncharacterized protein XP_059604195.1 2639235 R 5061 CDS An08g11100 84591840 join(2639868..2639964,2640040..2640086,2640144..2640269) VIII 1 NT_166524.1 hypothetical protein 2640269 84591840 An08g11100 Aspergillus niger hypothetical protein XP_059604196.1 2639868 D 5061 CDS An08g11110 84591841 join(2641240..2641314,2641402..2641447,2641586..2641619,2641705..2641774,2641951..2642058) VIII 1 NT_166524.1 hypothetical protein 2642058 84591841 An08g11110 Aspergillus niger hypothetical protein XP_059604197.1 2641240 D 5061 CDS An08g11120 4983426 2642255..2642989 VIII 1 NT_166524.1 Title: weak similarity to protein PRO4400 from patent WO200073348-A2 - Homo sapiens; uncharacterized protein 2642989 4983426 An08g11120 Aspergillus niger uncharacterized protein XP_001393214.1 2642255 D 5061 CDS An08g11130 4983427 complement(join(2643589..2643648,2643716..2643859)) VIII 1 NT_166524.1 hypothetical protein 2643859 4983427 An08g11130 Aspergillus niger hypothetical protein XP_001393215.3 2643589 R 5061 CDS An08g11140 84591842 complement(join(2644996..2645135,2645221..2645379,2645595..2645755,2645882..2645946,2646165..2646203)) VIII 1 NT_166524.1 hypothetical protein 2646203 84591842 An08g11140 Aspergillus niger hypothetical protein XP_059604198.1 2644996 R 5061 CDS An08g11150 84591843 2648486..2648773 VIII 1 NT_166524.1 hypothetical protein 2648773 84591843 An08g11150 Aspergillus niger hypothetical protein XP_059604199.1 2648486 D 5061 CDS An08g11160 4983430 join(2649139..2649437,2649490..2649709,2649764..2650451,2650504..2651402) VIII 1 NT_166524.1 Similarity: the weak similarity is due only to a very short, but very well conserved stretch of amino acids.; Title: weak similarity to hypothetical CG11414 -Drosophila melanogaster; uncharacterized protein 2651402 4983430 An08g11160 Aspergillus niger uncharacterized protein XP_059604200.1 2649139 D 5061 CDS An08g11170 84591844 2651998..2653022 VIII 1 NT_166524.1 Similarity: the predicted ORF has a questionable structure and probably constitutes a pseudogene as,relative to Ant1 of A. niger, it contains different frameshifts and two stop codons.; Title: strong similarity to protein encoded by ORF1 of transposon Ant1 - Aspergillus niger [putative pseudogene]; putative pseudogene; See PMID 8552048; 2653022 84591844 An08g11170 Aspergillus niger 2651998 D 5061 CDS An08g11180 4983433 2653892..2654893 VIII 1 NT_166524.1 Title: similarity to polypeptide SEQ ID NO:1833 from patent WO200171042-A2 - Drosophila melanogaster; uncharacterized protein 2654893 4983433 An08g11180 Aspergillus niger uncharacterized protein XP_001393220.3 2653892 D 5061 CDS An08g11190 84591845 2654979..2657594 VIII 1 NT_166524.1 Function: ankyrin is an essential link between cytoskeletal proteins and membrane bound proteins.; Similarity: strong similarity to A. niger EST SEQ ID NO:4268 of patent WO200056762-A2.; Similarity: the N-terminal part of the predicted protein shows no significant similarity.; Similarity: the similarity to various ankyrins is due to the presence of nine very well conserved ankyrin repeats in the C-terminal part of the predicted protein.; Title: similarity to ankyrin Ank1 - Mus musculus; See PMID 1386265; uncharacterized protein 2657594 84591845 An08g11190 Aspergillus niger uncharacterized protein XP_059604201.1 2654979 D 5061 CDS An08g11200 84591846 join(2658193..2658253,2658444..2658490,2658685..2659422,2659553..2660197) VIII 1 NT_166524.1 Title: similarity to hypothetical protein encoded by An03g02370 - Aspergillus niger; uncharacterized protein 2660197 84591846 An08g11200 Aspergillus niger uncharacterized protein XP_059604202.1 2658193 D 5061 CDS An08g11210 84591847 complement(join(<2661556..2662023,2662132..2662165)) VIII 1 NT_166524.1 Similarity: the predicted ORF has a questionable structure and probably constitutes a pseudogene as,relative to tan1 of A. awamorii, contains different frameshifts.; Title: similarity to transposable element Tan1 -Aspergillus niger [putative frameshift]; putative frameshift; See PMID 8625427; uncharacterized protein 2662165 84591847 An08g11210 Aspergillus niger uncharacterized protein XP_059604203.1 2661556 R 5061 CDS An08g11220 84591848 complement(join(2663821..2663936,2663988..2664513,2664751..2664825)) VIII 1 NT_166524.1 Function: mouse trophinin is a cell adhesion molecule mediating a unique homophilic cell adhesion between trophoblast and endometrial epithelial cells at their respective apical cell surfaces during embryo implantation and early placentation.; Similarity: the structure of the gene model is confirmed by A. niger EST SEQ ID NO:4090 of patent WO200056762-A2, which covers part of exon 2, exon 3 and part of the putative 3'UTR.; Title: weak similarity to cell adhesion protein trophinin Tro - Mus musculus; See PMID 10026108; See PMID 11089559; uncharacterized protein 2664825 84591848 An08g11220 Aspergillus niger uncharacterized protein XP_059604204.1 2663821 R 5061 CDS An08g11230 4983437 join(2665511..2665570,2665762..2666054,2666106..2666844) VIII 1 NT_166524.1 Similarity: strong similarity also to A. niger EST SEQ ID NO:4261 of patent WO200056762-A2.; Similarity: the gene model is confirmed by the two ESTs, which cover part of exon 2, the complete exon 3 and part of the putative 3'UTR.; Similarity: very weak similarity to other proteins cannot be considered functionally significant due to very different protein length.; Title: strong similarity to hypothetical protein encoded by An08g11410 - Aspergillus niger; uncharacterized protein 2666844 4983437 An08g11230 Aspergillus niger uncharacterized protein XP_001393224.3 2665511 D 5061 CDS An08g11240 84591849 join(2667207..2667236,2667328..2667372,2667469..2667583,2667669..2667757,2668237..2668359,2668442..2668726,2668814..2668897) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein encoded by An08g11430 - Aspergillus niger; uncharacterized protein 2668897 84591849 An08g11240 Aspergillus niger uncharacterized protein XP_059604205.1 2667207 D 5061 CDS An08g11250 84591850 complement(join(2669228..2669363,2669437..2669474,2669676..2669815,2669925..2669998,2670302..2670454,2670572..2670674,2670754..2670966,2671076..2671202)) VIII 1 NT_166524.1 Similarity: similarity to A. niger EST SEQ ID NO:4306 of patent WO200056762-A2.; Similarity: the weak similarity to ankyrin of D. melanogaster is due only to the presence of an ankyrin repeat.; Title: weak similarity to ankyrin - Drosophila melanogaster; See PMID 7937942; uncharacterized protein 2671202 84591850 An08g11250 Aspergillus niger uncharacterized protein XP_059604206.1 2669228 R 5061 CDS An08g11260 10098021 complement(join(2671425..2673902,2674064..2675203,2675352..2675488,2675661..2676516)) VIII 1 NT_166524.1 Similarity: the predicted ORF is very similar to the A. niger specific transposon Tncw1.; Title: strong similarity to reverse transcriptase homolog - Bombyx mori; See PMID 7623845; uncharacterized protein 2676516 10098021 An08g11260 Aspergillus niger uncharacterized protein XP_059604207.1 2671425 R 5061 CDS An08g11270 84591851 complement(join(2677115..2677171,2677230..2677311,2677455..2677525)) VIII 1 NT_166524.1 Title: questionable ORF; uncharacterized protein 2677525 84591851 An08g11270 Aspergillus niger uncharacterized protein XP_059604208.1 2677115 R 5061 CDS An08g11280 84591852 complement(join(2677789..2677858,2677923..2678014)) VIII 1 NT_166524.1 Title: questionable ORF; uncharacterized protein 2678014 84591852 An08g11280 Aspergillus niger uncharacterized protein XP_059604209.1 2677789 R 5061 CDS An08g11290 84591853 join(2678537..2678592,2678807..2678946,2679121..2679329) VIII 1 NT_166524.1 hypothetical protein 2679329 84591853 An08g11290 Aspergillus niger hypothetical protein XP_059604210.1 2678537 D 5061 CDS An08g11300 84591854 complement(join(2679455..2680276,2680545..2680889)) VIII 1 NT_166524.1 hypothetical protein 2680889 84591854 An08g11300 Aspergillus niger hypothetical protein XP_059604211.1 2679455 R 5061 CDS An08g11310 84591855 join(2681006..2681106,2681460..2681550,2682007..2682025,2682197..2682329,2682460..2682570,2682797..2682891,2683009..2683124,2683210..2683593,2683745..2683780) VIII 1 NT_166524.1 Title: weak similarity to hypothetical protein encoded by An11g07600 - Aspergillus niger; uncharacterized protein 2683780 84591855 An08g11310 Aspergillus niger uncharacterized protein XP_059604212.1 2681006 D 5061 CDS An08g11320 84591856 join(2683894..2684251,2684299..2684363) VIII 1 NT_166524.1 hypothetical protein 2684363 84591856 An08g11320 Aspergillus niger hypothetical protein XP_059604213.1 2683894 D 5061 CDS An08g11330 4983447 complement(2684578..2685375) VIII 1 NT_166524.1 Similarity: local identity to A. niger EST SEQ ID NO:4145 of patent WO200056762-A2, which is completely contained within the unique exon of the predicted gene.; Title: strong similarity to hypothetical protein encoded by An14g05450 - Aspergillus niger; uncharacterized protein 2685375 4983447 An08g11330 Aspergillus niger uncharacterized protein XP_001393234.3 2684578 R 5061 CDS An08g11340 84591857 join(2685683..2685724,2685759..2685925,2685976..2686147) VIII 1 NT_166524.1 Similarity: the gene model was extracted according to the patented EST, which covers exons 2 and 3 and the putative 3'UTR.; Title: strong similarity to EST SEQ ID NO:4160 from patent WO200056762-A2 - Aspergillus niger; uncharacterized protein 2686147 84591857 An08g11340 Aspergillus niger uncharacterized protein XP_059604214.1 2685683 D 5061 CDS An08g11350 84591858 join(2686261..2686279,2686381..2686555,2686612..2686819,2686911..2686974,2687304..2687374,2687461..2687752,2687827..2687961,2688028..2688141,2688205..2688317,2688492..2688824) VIII 1 NT_166524.1 Title: weak similarity to hypothetical clone MXL8 -Arabidopsis thaliana; uncharacterized protein 2688824 84591858 An08g11350 Aspergillus niger uncharacterized protein XP_059604215.1 2686261 D 5061 CDS An08g11360 84591859 complement(join(2688865..2689048,2689109..2689159,2689338..2689412,2689522..2689592)) VIII 1 NT_166524.1 Title: weak similarity to EST an_1431 - Aspergillus niger; uncharacterized protein 2689592 84591859 An08g11360 Aspergillus niger uncharacterized protein XP_059604216.1 2688865 R 5061 CDS An08g11370 84591860 complement(join(2689912..2690084,2690176..2690264,2690344..2690490,2690669..2690739,2690818..2690871)) VIII 1 NT_166524.1 hypothetical protein 2690871 84591860 An08g11370 Aspergillus niger hypothetical protein XP_059604217.1 2689912 R 5061 CDS An08g11380 4983452 2691444..2692211 VIII 1 NT_166524.1 hypothetical protein 2692211 4983452 An08g11380 Aspergillus niger hypothetical protein XP_001393239.3 2691444 D 5061 CDS An08g11390 4983453 join(2692841..2693126,2693177..2696220,2696410..2700958,2701029..2702281) VIII 1 NT_166524.1 Similarity: the ORF encoded protein shows also weak similarity to the possible elongation factor 2 LM28. 365 from Leishmania major.; Title: weak similarity to hypothetical protein CAC01058.1 - Leishmania major; uncharacterized protein 2702281 4983453 An08g11390 Aspergillus niger uncharacterized protein XP_059604218.1 2692841 D 5061 CDS An08g11400 84591861 join(2703280..2703424,2703633..2703781) VIII 1 NT_166524.1 Similarity: ALK6 of Y. lipolitica is similar to cytochrome P450 family members; the similarity to the predicted protein is weak and limited to a very small part of the entire protein.; Title: weak similarity to ALK6 - Yarrowia lipolitica; See PMID 10953079; uncharacterized protein 2703781 84591861 An08g11400 Aspergillus niger uncharacterized protein XP_059604219.1 2703280 D 5061 CDS An08g11410 4983455 join(2704022..2704053,2704108..2704819) VIII 1 NT_166524.1 Similarity: the predicted ORF shows also strong similarity to EST SEQ ID NO:4261 of patent WO200056762-A2,A. niger.; Similarity: the predicted protein shows also some local weak similarity to proteins with very different size.; Similarity: the two ESTs cover the ORF completely,and part of the putative 3'UTR; the gene model was extracted based on these cDNA sequences.; Title: strong similarity to hypothetical protein encoded by An08g11230 - Aspergillus niger; uncharacterized protein 2704819 4983455 An08g11410 Aspergillus niger uncharacterized protein XP_001393242.3 2704022 D 5061 CDS An08g11420 84591862 complement(join(2705144..2705176,2705259..2705291,2705505..2705597,2705625..2705636)) VIII 1 NT_166524.1 Title: questionable ORF; uncharacterized protein 2705636 84591862 An08g11420 Aspergillus niger uncharacterized protein XP_059604220.1 2705144 R 5061 CDS An08g11430 84591863 <2706248..2706772 VIII 1 NT_166524.1 Remark: N-terminal truncated ORF due to end of contig.; Title: strong similarity to hypothetical protein encoded by An08g11240 - Aspergillus niger [truncated ORF]; uncharacterized protein 2706772 84591863 An08g11430 Aspergillus niger uncharacterized protein XP_059604221.1 2706248 D 5061 CDS An08g11440 84591864 complement(join(2708097..2708595,2708722..2708783)) VIII 1 NT_166524.1 Remark: gankyrin expression induced in liver fibrosis accelerated the degradation of pRB during liver cirrhosis, and inactivation of p16 exon 1 by DNA hypermethylation occurred during the progression of tumor cells to poorly differentiated HCC (hepatocellular carcinoma).; Remark: similarity to rat gankyrin protein patent WO9918201-A1.; Title: similarity to gankyrin protein from patent WO9918201-A1 - Rattus norvegicus; See PMID 11301474; uncharacterized protein 2708783 84591864 An08g11440 Aspergillus niger uncharacterized protein XP_059604222.1 2708097 R 5061 CDS An08g11450 84591865 complement(join(2709533..2709959,2710080..2710420)) VIII 1 NT_166524.1 Title: weak similarity to hypothetical protein encoded by An07g06380 - Aspergillus niger; uncharacterized protein 2710420 84591865 An08g11450 Aspergillus niger uncharacterized protein XP_059604223.1 2709533 R 5061 CDS An08g11460 84591866 join(2711718..2711733,2712346..2712494) VIII 1 NT_166524.1 Title: questionable ORF; uncharacterized protein 2712494 84591866 An08g11460 Aspergillus niger uncharacterized protein XP_059604224.1 2711718 D 5061 CDS An08g11480 84591867 complement(join(2714280..2714788,2714836..2714890,2714976..2715074)) VIII 1 NT_166524.1 Title: weak similarity to AT hook-containing MAR-binding protein2 AHM2 - Triticum aestivum; uncharacterized protein 2715074 84591867 An08g11480 Aspergillus niger uncharacterized protein XP_059604225.1 2714280 R 5061 CDS An08g11490 84591868 complement(join(2715554..2715717,2715808..2715912,2716013..2716035,2716117..2716205,2716376..2716436,2716512..2716618)) VIII 1 NT_166524.1 hypothetical protein 2716618 84591868 An08g11490 Aspergillus niger hypothetical protein XP_059604226.1 2715554 R 5061 CDS An08g11500 84591869 join(2717079..2717129,2717187..2717237,2717296..2717358,2717407..2717827,2717903..2717946) VIII 1 NT_166524.1 hypothetical protein 2717946 84591869 An08g11500 Aspergillus niger hypothetical protein XP_059604227.1 2717079 D 5061 CDS An08g11510 4983464 join(2718998..2719992,2720052..2720091,2720191..2724090) VIII 1 NT_166524.1 Remark: TRAS1 contains gag- and pol-like open reading frames (ORFs) which are similar to those of non-LTR retrotransposons. Chromosomal in situ hybridization showed that TRAS1 elements are clustered at the telomeres of Bombyx chromosomes. A phylogenetic analysis using the amino acid sequence of the reverse transcriptase domain within the pol-like ORF revealed that TRAS1 falls into one lineage with R1, which is a family of non-LTR retrotransposons inserted into the same sitewithin the 28S ribosomal DNA unit in most insects.; Title: strong similarity to retrotransposable element TRAS1 - Bombyx mori; See PMID 7623845; uncharacterized protein 2724090 4983464 An08g11510 Aspergillus niger uncharacterized protein XP_059604228.1 2718998 D 5061 CDS An08g11520 4983465 join(2724419..2725441,2725575..2729510) VIII 1 NT_166524.1 Remark: Mars (methylated Ascobolus repeated sequences), fell in one family of LINE-like elements and in three families of LTR-containing retrotransposable elements. The methylation features of Mars elements were those expected if they were natural targets for the MIP (methylation induced premeiotically) previously discovered in Ascobolus.; Similarity: to RNA-directed DNA polymerases.; Title: strong similarity to LTR-containing retrotransposable elements MARS1 - Ascobolus immersus; See PMID 8811089; uncharacterized protein 2729510 4983465 An08g11520 Aspergillus niger uncharacterized protein XP_059604229.1 2724419 D 5061 CDS An08g11530 84591870 join(2730335..2730426,2730557..2730704,2730761..2731143,2731208..2731286) VIII 1 NT_166524.1 hypothetical protein 2731286 84591870 An08g11530 Aspergillus niger hypothetical protein XP_059604230.1 2730335 D 5061 CDS An08g11540 4983467 complement(join(2731672..2733029,2733121..2733502)) VIII 1 NT_166524.1 Function: interacts with dnaK,to disassemble a protein complex at the phage lambda origin of replication. Stimulates,jointly with grpE,the ATPase activity of dnaK.; Remark: similarity to E. coli OmpA-DnaJ fusion protein encoded by pUBS520-pIN-dnaJ patent EP1054063-A2.; Title: similarity to OmpA-DnaJ fusion protein encoded by pUBS520-pIN-dnaJ from patent EP1054063-A2 -Escherichia coli; See PMID 8016869; uncharacterized protein 2733502 4983467 An08g11540 Aspergillus niger uncharacterized protein XP_001393254.1 2731672 R 5061 CDS An08g11550 84591871 join(2733886..2734158,2734230..2734328,2734714..2735019) VIII 1 NT_166524.1 hypothetical protein 2735019 84591871 An08g11550 Aspergillus niger hypothetical protein XP_059604231.1 2733886 D 5061 CDS An08g11560 4983469 complement(join(2735205..2735486,2735545..2735813,2735901..2735910)) VIII 1 NT_166524.1 Title: weak similarity to hypothetical MADS box transcription factor-like protein BAB11255.1 - Arabidopsis thaliana; uncharacterized protein 2735910 4983469 An08g11560 Aspergillus niger uncharacterized protein XP_001393256.3 2735205 R 5061 CDS An08g11570 84591872 complement(2737306..2737905) VIII 1 NT_166524.1 Title: weak similarity to hypothetical protein DKFZp564A022 - Homo sapiens; uncharacterized protein 2737905 84591872 An08g11570 Aspergillus niger uncharacterized protein XP_059604232.1 2737306 R 5061 CDS An08g11580 4983471 join(2738797..2738858,2738916..2739516,2739555..2739686) VIII 1 NT_166524.1 Remark: only repetitive sequences are matching.; Title: weak similarity to mucin MUC5AC - Homo sapiens; See PMID 7826332; uncharacterized protein 2739686 4983471 An08g11580 Aspergillus niger uncharacterized protein XP_059604233.1 2738797 D 5061 CDS An08g11590 10098024 complement(join(2740752..2741297,2741376..2741447,2741667..2741680,2741715..2741781,2742022..2742882,2743083..2743115,2743251..2743271)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical related to spore coat protein SP96 B15I20.140 - Neurospora crassa; uncharacterized protein 2743271 10098024 An08g11590 Aspergillus niger uncharacterized protein XP_003188767.2 2740752 R 5061 CDS An08g11600 4983473 complement(2744694..2745293) VIII 1 NT_166524.1 Similarity: the ORF encoded protein shows also weak similarity to hypothetical protein 15E6. 200 from Neurospora crassa; Title: weak similarity to hypothetical protein 15E6.200 - Neurospora crassa; uncharacterized protein 2745293 4983473 An08g11600 Aspergillus niger uncharacterized protein XP_001393260.3 2744694 R 5061 CDS An08g11610 4983474 complement(join(2745686..2747143,2747267..2749000)) VIII 1 NT_166524.1 Function: kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.; Remark: the C-terminal domain shows homology to the kinesin light chain of different organisms. The N-terminal domain of the predicted ORF shows weak similarity to putative ATP /GTP-binding proteins.; Title: similarity to kinesin light chain KNLC -Loligo pealei; See PMID 8274223; uncharacterized protein 2749000 4983474 An08g11610 Aspergillus niger uncharacterized protein XP_059604234.1 2745686 R 5061 CDS An08g11620 4983475 complement(<2749354..2750459) VIII 1 NT_166524.1 Remark: Ant1 is related to the Tc1/mariner group of DNA transposons. Ant1 is apparently present as a single copy in strain N402 of A. niger.; Title: strong similarity to protein encoded by ORF1 of transposon Ant1 - Aspergillus niger [putative frameshift]; putative frameshift; See PMID 8552048; uncharacterized protein 2750459 4983475 An08g11620 Aspergillus niger uncharacterized protein XP_001393262.3 2749354 R 5061 CDS An08g11630 84591873 join(2752017..2752195,2752252..2752342) VIII 1 NT_166524.1 Title: weak similarity to ubiquitin thiolesterase Yuh1 - Saccharomyces cerevisiae; uncharacterized protein 2752342 84591873 An08g11630 Aspergillus niger uncharacterized protein XP_059604235.1 2752017 D 5061 CDS An08g11640 84591874 complement(2752742..2753500) VIII 1 NT_166524.1 hypothetical protein 2753500 84591874 An08g11640 Aspergillus niger hypothetical protein XP_059604236.1 2752742 R 5061 CDS An08g11650 84591875 complement(join(<2765986..2766160,2766265..2766503,2766616..2766624)) VIII 1 NT_166524.1 Title: weak similarity to protein 35142 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 2766624 84591875 An08g11650 Aspergillus niger uncharacterized protein XP_059606251.1 2765986 R 5061 CDS An08g11660 84591876 complement(join(2766758..2767222,2767452..2767493)) VIII 1 NT_166524.1 Remark: a putative sequencing error results in an frameshift.; Title: similarity to kinesin light chain KLC -Plectonema boryanum [putative sequencing error]; putative sequencing error; uncharacterized protein 2767493 84591876 An08g11660 Aspergillus niger uncharacterized protein XP_059606252.1 2766758 R 5061 CDS An08g11670 84591877 join(2767907..2767996,2768102..2768131,2768162..2768255,2768358..2768468,2768689..2768702,2768976..2769186,2769321..2769352,2769588..2769697,2769758..2770520) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein encoded by An04g01250 - Aspergillus niger; uncharacterized protein 2770520 84591877 An08g11670 Aspergillus niger uncharacterized protein XP_059606253.1 2767907 D 5061 CDS An08g11680 10098027 complement(join(2773435..2773816,2773871..2774235,2774327..2774371)) VIII 1 NT_166524.1 Function: degradation of 2,5-dichloro-2,5-cyclohexadiene-1,4-diol into 2,5-dichlorohydroquinone.; Pathway: degradation of gamma-hexachlorocyclohexane.; Remark: also strong similarity to EST an_3163 Aspergillus niger.; Remark: the linC gene is essential for the assimilation of gamma-HCH in UT26.; Title: strong similarity to 2,5-dicloro-2,5-cyclohexadiene-1,4-diol dehydrogenase linC - Pseudomonas paucimobilis; uncharacterized protein 2774371 10098027 An08g11680 Aspergillus niger uncharacterized protein XP_059606254.1 2773435 R 5061 CDS An08g11690 84591878 join(2776375..2776441,2776489..2776521,2776721..2776867,2776913..2777136) VIII 1 NT_166524.1 hypothetical protein 2777136 84591878 An08g11690 Aspergillus niger hypothetical protein XP_059606255.1 2776375 D 5061 CDS An08g11700 84591879 complement(join(2778337..2778573,2778666..2778749,2779234..2779293,2779399..2779566)) VIII 1 NT_166524.1 hypothetical protein 2779566 84591879 An08g11700 Aspergillus niger hypothetical protein XP_059606256.1 2778337 R 5061 CDS An08g11710 84591880 complement(join(2780737..2780757,2780869..2780877,2780990..2781022,2781095..2781298)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein encoded by An04g07770 - Aspergillus niger; uncharacterized protein 2781298 84591880 An08g11710 Aspergillus niger uncharacterized protein XP_059606257.1 2780737 R 5061 CDS An08g11720 4983485 complement(join(2781581..2781837,2781907..2782111,2782318..2782531,2783130..2783516,2783575..2783718,2783766..2783803,2784096..2784276,2784330..2784484,2784614..2784638,2784781..2784866,2785058..2785102)) VIII 1 NT_166524.1 hypothetical protein 2785102 4983485 An08g11720 Aspergillus niger hypothetical protein XP_059606258.1 2781581 R 5061 CDS An08g11730 84591881 join(2786291..2786473,2786533..2787729) VIII 1 NT_166524.1 hypothetical protein 2787729 84591881 An08g11730 Aspergillus niger hypothetical protein XP_059606259.1 2786291 D 5061 CDS An08g11740 84591882 join(<2789485..2789636,2789722..2790008,2790047..2790123) VIII 1 NT_166524.1 Remark: the ORF is N-terminally truncated due to end of contig.; hypothetical protein [truncated ORF] 2790123 84591882 An08g11740 Aspergillus niger hypothetical protein [truncated ORF] XP_059606933.1 2789485 D 5061 CDS An08g11750 84591883 complement(join(2790189..2791106,2791155..2791202)) VIII 1 NT_166524.1 hypothetical protein 2791202 84591883 An08g11750 Aspergillus niger hypothetical protein XP_059606934.1 2790189 R 5061 CDS An08g11760 4983489 join(2791896..2792075,2792128..2793216) VIII 1 NT_166524.1 hypothetical protein 2793216 4983489 An08g11760 Aspergillus niger hypothetical protein XP_001393276.3 2791896 D 5061 CDS An08g11770 4983490 complement(join(2795761..2796302,2796353..2796549,2796600..2796680,2796731..2798044,2798104..2798213,2798272..2798535)) VIII 1 NT_166524.1 Similarity: contains a fungal-type Zn(2)-Cys(6) binuclear cluster DNA-binding domain.; Title: weak similarity to gluconeogenesis transcriptional regulator CAT8 - Kluyveromyces lactis; See PMID 11016849; uncharacterized protein 2798535 4983490 An08g11770 Aspergillus niger uncharacterized protein XP_001393277.3 2795761 R 5061 CDS An08g11780 4983491 join(2799242..2799954,2800007..2801356,2801412..2801532,2801585..2801647,2801700..2801939,2801988..2802230,2802279..2802515,2802565..2802759) VIII 1 NT_166524.1 hypothetical protein 2802759 4983491 An08g11780 Aspergillus niger hypothetical protein XP_001393278.3 2799242 D 5061 CDS An08g11790 4983492 complement(join(2805795..2805842,2805902..2806495)) VIII 1 NT_166524.1 Similarity: CDS is nearly identical to DNA sequence of the DNA patent database entry PATENTDNA:AAF11722.; Similarity: shares homology with a conserved domain of several protein kinases.; Similarity: the ORF encoded protein shows also strong similarity to EST SEQ ID NO:4245 of patent WO200056762-A2 from Aspergillus niger; Title: strong similarity to hypothetical protein encoded by An06g00610 - Aspergillus niger; uncharacterized protein 2806495 4983492 An08g11790 Aspergillus niger uncharacterized protein XP_001393279.3 2805795 R 5061 CDS An08g11800 4983493 join(2807136..2807854,2808412..2808462,2808507..2808858) VIII 1 NT_166524.1 hypothetical protein 2808858 4983493 An08g11800 Aspergillus niger hypothetical protein XP_001393280.3 2807136 D 5061 CDS An08g11810 4983494 complement(join(2809554..2809589,2809720..2809776,2809916..2809922,2810261..2810286,2810335..2810361,2810391..2810451,2810676..2810962,2811014..2811190)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein encoded by An04g07800 - Aspergillus niger; uncharacterized protein 2811190 4983494 An08g11810 Aspergillus niger uncharacterized protein XP_059606935.1 2809554 R 5061 CDS An08g11820 84591884 complement(join(2812181..2812577,2812630..2812723,2812764..2812785,2813032..2813226,2813411..2813480,2813535..2813818)) VIII 1 NT_166524.1 Similarity: contains a C2H2-type zinc-finger domain.; Title: weak similarity to Gli-Kruppel zinc-finger protein NKL isoform b - Xenopus laevis; uncharacterized protein 2813818 84591884 An08g11820 Aspergillus niger uncharacterized protein XP_059606936.1 2812181 R 5061 CDS An08g11830 84591885 complement(join(2814087..2815124,2815283..2815285)) VIII 1 NT_166524.1 hypothetical protein 2815285 84591885 An08g11830 Aspergillus niger hypothetical protein XP_059606937.1 2814087 R 5061 CDS An08g11840 84591886 complement(join(2816692..2816926,2816982..2817331)) VIII 1 NT_166524.1 hypothetical protein 2817331 84591886 An08g11840 Aspergillus niger hypothetical protein XP_059606938.1 2816692 R 5061 CDS An08g11850 84591887 join(2817697..2818006,2818123..2818238) VIII 1 NT_166524.1 hypothetical protein 2818238 84591887 An08g11850 Aspergillus niger hypothetical protein XP_059606939.1 2817697 D 5061 CDS An08g11860 4983499 join(2818771..2818995,2819058..2819402,2819456..2820490) VIII 1 NT_166524.1 Catalytic activity: cephalosporin C + H2O = deacetylcephalosporin C + acetate.; Function: cephalosporin esterase of R. toruloides is capable of interconverting a variety of cephalosporin species and the corresponding deacetylcephalosporins.; Similarity: belongs to the carboxylesterase type-B family.; Title: strong similarity to precursor of cephalosporin esterase - Rhodosporidium toruloides; See PMID 9406399; uncharacterized protein 2820490 4983499 An08g11860 Aspergillus niger uncharacterized protein XP_001393286.1 2818771 D 5061 CDS An08g11870 84591888 complement(join(2820894..2821164,2821219..2821757,2821811..2821996,2822121..2822578,2822628..2822694,2822748..2822825)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein encoded by An04g07990 - Aspergillus niger; uncharacterized protein 2822825 84591888 An08g11870 Aspergillus niger uncharacterized protein XP_059606940.1 2820894 R 5061 CDS An08g11880 84591889 complement(join(2823868..2823901,2823953..2824041)) VIII 1 NT_166524.1 Title: questionable ORF; uncharacterized protein 2824041 84591889 An08g11880 Aspergillus niger uncharacterized protein XP_059606941.1 2823868 R 5061 CDS An08g11890 4983502 join(2824404..2824897,2824962..2825094) VIII 1 NT_166524.1 Similarity: contains a myb-like DNA-binding domain.; Title: similarity to hypothetical protein B24P11.50 - Neurospora crassa; uncharacterized protein 2825094 4983502 An08g11890 Aspergillus niger uncharacterized protein XP_001393289.1 2824404 D 5061 CDS An08g11900 84591890 complement(join(2826754..2826835,2826868..2826971,2827193..2827546,2827596..2827616)) VIII 1 NT_166524.1 hypothetical protein 2827616 84591890 An08g11900 Aspergillus niger hypothetical protein XP_059606942.1 2826754 R 5061 CDS An08g11910 84591891 complement(join(2827800..2828114,2828209..2828303,2828383..2828558,2828752..2828855,2828942..2829045,2829213..2829375)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein encoded by An08g12260 - Aspergillus niger; uncharacterized protein 2829375 84591891 An08g11910 Aspergillus niger uncharacterized protein XP_059606943.1 2827800 R 5061 CDS An08g11920 84591892 complement(join(<2830103..2830378,2830490..2830585)) VIII 1 NT_166524.1 Remark: the ORF encoded protein is C-terminally truncated due to the contig border.; hypothetical protein [truncated ORF] 2830585 84591892 An08g11920 Aspergillus niger hypothetical protein [truncated ORF] XP_059601254.1 2830103 R 5061 CDS An08g11930 4983506 join(2831091..2832833,2833077..2833115,2833210..2833614) VIII 1 NT_166524.1 Function: ankyrin participates in signal transduction and in assembly of integral membrane proteins.; Function: ankyrins are linker proteins, which connect various membrane proteins, including members of the L1 family of neural cell adhesion molecules, with the submembranous actin-spectrin skeleton.; Title: similarity to ankyrin 2 Ank2 - Drosophila melanogaster; See PMID 10844021; See PMID 11018513; uncharacterized protein 2833614 4983506 An08g11930 Aspergillus niger uncharacterized protein XP_059601255.1 2831091 D 5061 CDS An08g11940 84591893 join(2834248..2834416,2834479..2834751,2834862..2834914,2835258..2835428) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein encoded by An08g12220 - Aspergillus niger; uncharacterized protein 2835428 84591893 An08g11940 Aspergillus niger uncharacterized protein XP_059601256.1 2834248 D 5061 CDS An08g11950 84591894 complement(join(2836106..2836136,2836166..2836319,2836556..2836720,2836839..2837619)) VIII 1 NT_166524.1 Function: nompC gene of D. melanogaster encodes a new ion channel that is essential for mechanosensory transduction.; Remark: the ORF encoded protein also shows similarity to other ankyrin repeat containing proteins.; Remark: the similarity of the ORF encoded protein to NOMPC is restricted to the ankyrin repeats. Unlike NOMPC,the ORF encoded Protein does not seem to be an ion channel.; Title: similarity to mechanosensory transduction channel nompC - Drosophila melanogaster; See PMID 10744543; uncharacterized protein 2837619 84591894 An08g11950 Aspergillus niger uncharacterized protein XP_059601257.1 2836106 R 5061 CDS An08g11960 84591895 join(2839326..2839397,2839519..2840130) VIII 1 NT_166524.1 Title: similarity to hypothetical protein SPAC15A10.09c - Schizosaccharomyces pombe; uncharacterized protein 2840130 84591895 An08g11960 Aspergillus niger uncharacterized protein XP_059601258.1 2839326 D 5061 CDS An08g11970 84591896 join(2841413..2841472,2841583..2841857,2841961..2842046,2842719..2842884,2842965..2843115) VIII 1 NT_166524.1 hypothetical protein 2843115 84591896 An08g11970 Aspergillus niger hypothetical protein XP_059601259.1 2841413 D 5061 CDS An08g11980 84591897 join(2843701..2843752,2843822..2844078,2844160..2844336,2844422..2844511) VIII 1 NT_166524.1 hypothetical protein 2844511 84591897 An08g11980 Aspergillus niger hypothetical protein XP_059601260.1 2843701 D 5061 CDS An08g11990 4983512 join(2844626..2844718,2844772..2845427,2845474..2846047) VIII 1 NT_166524.1 Similarity: the similarity to the A. niger ORF An08g12030 covers only the N-terminal 30 aminoacids.; Title: weak similarity to hypothetical protein encoded by An08g12030 - Aspergillus niger; uncharacterized protein 2846047 4983512 An08g11990 Aspergillus niger uncharacterized protein XP_059601261.1 2844626 D 5061 CDS An08g12000 84591898 join(2847013..2847061,2847286..2847360,2847480..2847561,2847608..2847722) VIII 1 NT_166524.1 hypothetical protein 2847722 84591898 An08g12000 Aspergillus niger hypothetical protein XP_059601262.1 2847013 D 5061 CDS An08g12010 4983514 complement(join(2849299..2849625,2849801..2849938)) VIII 1 NT_166524.1 hypothetical protein 2849938 4983514 An08g12010 Aspergillus niger hypothetical protein XP_059601263.1 2849299 R 5061 CDS An08g12020 84591899 complement(join(2850155..2850337,2850384..2850497,2850584..2850700)) VIII 1 NT_166524.1 hypothetical protein 2850700 84591899 An08g12020 Aspergillus niger hypothetical protein XP_059601264.1 2850155 R 5061 CDS An08g12030 84591900 join(2850809..2851030,2851131..2851325) VIII 1 NT_166524.1 Similarity: the similarity to the A. niger ORF An08g11990 covers only the N-terminal 30 aminoacids.; Title: weak similarity to hypothetical protein encoded by An08g11990 - Aspergillus niger; uncharacterized protein 2851325 84591900 An08g12030 Aspergillus niger uncharacterized protein XP_059601265.1 2850809 D 5061 CDS An08g12040 84591901 join(2851668..2851676,2851726..2851806,2851854..2851949) VIII 1 NT_166524.1 hypothetical protein 2851949 84591901 An08g12040 Aspergillus niger hypothetical protein XP_059601266.1 2851668 D 5061 CDS An08g12060 4983519 join(2856185..2856213,2856267..2856762,2856880..2856986,2857017..2857040,2857226..2857343,2857695..2857922) VIII 1 NT_166524.1 Title: weak similarity to stromelysin from patent WO8707907-A - Homo sapiens; uncharacterized protein 2857922 4983519 An08g12060 Aspergillus niger uncharacterized protein XP_059601267.1 2856185 D 5061 CDS An08g12070 4983520 complement(join(2858087..2858652,2858803..2859298,2859337..2859626,2859670..2860219)) VIII 1 NT_166524.1 Remark: the similarity of the ORF encoded protein to PIM of T. parva is mainly based on repetitive amino acids.; Title: similarity to hypothetical polymorphic immunodominant molecule PIM - Theileria parva; uncharacterized protein 2860219 4983520 An08g12070 Aspergillus niger uncharacterized protein XP_059601268.1 2858087 R 5061 CDS An08g12080 84591902 complement(join(2861817..2862159,2862212..2862627,2862771..2863127,2863223..2863306,2863411..2863464,2863515..2863649,2863789..2863791)) VIII 1 NT_166524.1 Title: similarity to hypothetical protein encoded by An04g07900 - Aspergillus niger; uncharacterized protein 2863791 84591902 An08g12080 Aspergillus niger uncharacterized protein XP_059601269.1 2861817 R 5061 CDS An08g12090 84591903 complement(join(2864448..2864554,2864606..2864795,2864857..2864982,2865052..2865231)) VIII 1 NT_166524.1 hypothetical protein 2865231 84591903 An08g12090 Aspergillus niger hypothetical protein XP_059601270.1 2864448 R 5061 CDS An08g12100 84591904 join(2866998..2867045,2867088..2867158,2867367..2867483,2867642..2867708) VIII 1 NT_166524.1 hypothetical protein 2867708 84591904 An08g12100 Aspergillus niger hypothetical protein XP_059601271.1 2866998 D 5061 CDS An08g12110 4983524 complement(2868165..2870456) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein EAA61328.1 - Aspergillus nidulans; uncharacterized protein 2870456 4983524 An08g12110 Aspergillus niger uncharacterized protein XP_001393311.1 2868165 R 5061 CDS An08g12120 84591905 join(2870997..2871133,2871298..2871433,2871640..2872068) VIII 1 NT_166524.1 Title: weak similarity to hypothetical mycosubtilin synthase chain mycA - Bacillus subtilis; uncharacterized protein 2872068 84591905 An08g12120 Aspergillus niger uncharacterized protein XP_059601272.1 2870997 D 5061 CDS An08g12130 84591906 complement(join(2873902..2873997,2874098..2874236,2874335..2874449,2874848..2874964,2875089..2875150,2875457..2875532,2875614..2875652,2875837..2875918)) VIII 1 NT_166524.1 hypothetical protein 2875918 84591906 An08g12130 Aspergillus niger hypothetical protein XP_059601273.1 2873902 R 5061 CDS An08g12140 84591907 join(2875973..2876332,2876381..2876601,2876650..2876881) VIII 1 NT_166524.1 Remark: the ORF encoded protein show similarity to many zinc finger transcription factors.; Title: weak similarity to finger protein Xfin -Xenopus laevis; uncharacterized protein 2876881 84591907 An08g12140 Aspergillus niger uncharacterized protein XP_059601274.1 2875973 D 5061 CDS An08g12150 4983528 complement(join(2877126..2878138,2878194..2878746)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein encoded by An11g07550 - Aspergillus niger; uncharacterized protein 2878746 4983528 An08g12150 Aspergillus niger uncharacterized protein XP_001393315.1 2877126 R 5061 CDS An08g12160 4983529 join(2879641..2887840,2887897..2889224) VIII 1 NT_166524.1 Similarity: the ORF encoded protein shows also weak similarity to the possible elongation factor 2 LM28. 365 from Leishmania major.; Title: strong similarity to hypothetical protein encoded by An08g11390 - Aspergillus niger; uncharacterized protein 2889224 4983529 An08g12160 Aspergillus niger uncharacterized protein XP_059601275.1 2879641 D 5061 CDS An08g12170 4983530 complement(join(2891753..2891923,2891974..2892282,2892347..2893271,2893304..2893915,2894099..2894323,2894377..>2895641)) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein encoded by An18g02760 - Aspergillus niger [truncated ORF]; uncharacterized protein 2895641 4983530 An08g12170 Aspergillus niger uncharacterized protein XP_059601276.1 2891753 R 5061 CDS An08g12180 84591908 join(2896044..2896085,2896139..2896148,2896310..2896363,2896585..2896589,2896623..2896667,2896865..2896897) VIII 1 NT_166524.1 Title: questionable ORF; uncharacterized protein 2896897 84591908 An08g12180 Aspergillus niger uncharacterized protein XP_059601277.1 2896044 D 5061 CDS An08g12200 4983532 join(2898209..2899184,2899241..2900874,2900931..2901691,2901724..2901827,2902062..2902147) VIII 1 NT_166524.1 Function: H. sapiens TAFII100 interacts strongly with the histone H4-related TAFII80 and the histone H3-related TAFII31, as well as a stable complex comprised of both TAFII80 and TAFII31.; Remark: distinct domains of H. sapiens TAFII100 are required for functional interaction with transcription factor TFIIFB (RAP30) and incorporation into the TFIID complex.; Similarity: similarities are restricted to the C-terminus which contains several WD-domains presumably involved in protein-protein interactions, BlastX analysis of N-terminus showed no significant matches.; Title: similarity to transcription initiation factor TFIID 100 kD subunit TAFII-100 - Homo sapiens; nucleus; See PMID 8758937; uncharacterized protein 2902147 4983532 An08g12200 Aspergillus niger uncharacterized protein XP_059601278.1 2898209 D 5061 CDS An08g12210 10098028 join(2903473..2905569,2905698..2907335) VIII 1 NT_166524.1 Title: strong similarity to hypothetical retrotransposable element TRAS1 - Bombyx mori; uncharacterized protein 2907335 10098028 An08g12210 Aspergillus niger uncharacterized protein XP_059601279.1 2903473 D 5061 CDS An08g12220 10098029 complement(join(2908138..2908597,2908702..2909390,2909534..2909680,2909829..2909921,2910058..2910110,2910221..2910493,2910556..2910763)) VIII 1 NT_166524.1 Function: TRI7 of F. sporotrichioides is required for acetylation of the oxygen on C-4 of T-2 toxin.; Pathway: TRI7 of F. sporotrichioides contributes in the trichothecene T2-toxin synthesis.; Remark: trichothecenes are sesquiterpenoid mycotoxins and act as protein synthesis inhibitors for eukaryotic organisms.; Title: similarity to T-2 toxin biosynthesis protein TRI7 - Fusarium sporotrichioides; See PMID 11352533; uncharacterized protein 2910763 10098029 An08g12220 Aspergillus niger uncharacterized protein XP_059601280.1 2908138 R 5061 CDS An08g12230 10098030 complement(join(2911353..2911757,2911852..2911890,2912134..2912825,2913453..2913876)) VIII 1 NT_166524.1 Remark: patentmatch against protein A47074_1 Trembl.; Title: similarity to delta-latroinsectotoxin from patent GB2288807-A - Latrodectus tredecimguttatus; uncharacterized protein 2913876 10098030 An08g12230 Aspergillus niger uncharacterized protein XP_059601281.1 2911353 R 5061 CDS An08g12240 4983536 complement(join(2914643..2917243,2917310..2917393,2917477..2917662)) VIII 1 NT_166524.1 Similarity: weak similarity to SCOP domain in Cytochrome P450-NOR, nitric reductase Fusarium oxysporum.; Title: weak similarity to hypothetical protein encoded by An12g06670 - Aspergillus niger; uncharacterized protein 2917662 4983536 An08g12240 Aspergillus niger uncharacterized protein XP_059601282.1 2914643 R 5061 CDS An08g12250 4983537 complement(join(2919579..2920563,2920718..2920772,2920918..2921250,2921344..2921895,2922003..2922978)) VIII 1 NT_166524.1 Catalytic activity: Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a fatty acid anion.; Title: weak similarity to calcium-independent phospholipase A2 - Homo sapiens; See PMID 10833412; uncharacterized protein 2922978 4983537 An08g12250 Aspergillus niger uncharacterized protein XP_059601283.1 2919579 R 5061 CDS An08g12260 84591909 join(2923946..2924002,2924331..2924468,2924560..2924630,2924834..2925041) VIII 1 NT_166524.1 Title: strong similarity to hypothetical protein encoded by An08g11910 - Aspergillus niger; uncharacterized protein 2925041 84591909 An08g12260 Aspergillus niger uncharacterized protein XP_059601284.1 2923946 D 5061 CDS An18g00010 4989573 join(944..1218,1287..1404,1475..1560,1628..1817) VIII 1 NT_166533.1 Catalytic activity: RDH of K. aerogenes catalyzes the reaction ribitol + NAD+ = D-ribulose + NADH.; Complex: RDH of K. aerogenes forms homotetramers.; Pathway: RDH of K. aerogenes is involved in the pentose interconversion pathway.; Similarity: the protein shows domain similarity to the short-chain alcohol dehydrogenases.; Similarity: the protein shows similarity to the dltE protein of B. subtilis, which belongs to the D-alanyl-lipoteichoic acid operon, but whose function is unknown.; Title: similarity to ribitol 2-dehydrogenase RDH -Klebsiella aerogenes; See PMID 1946424; See PMID 3904726; See PMID 7797557; uncharacterized protein 1817 4989573 An18g00010 Aspergillus niger uncharacterized protein XP_059602845.1 944 D 5061 CDS An18g00020 84593610 complement(join(2043..2138,2182..2199)) VIII 1 NT_166533.1 hypothetical protein 2199 84593610 An18g00020 Aspergillus niger hypothetical protein XP_059602846.1 2043 R 5061 CDS An18g00030 4989597 join(3821..3976,4034..4228,4294..4388,4448..4848,4905..5030,5077..5192,5246..5332,5390..5506,5569..5653,5720..5901) VIII 1 NT_166533.1 Function: based on sequence similarity, Liz1 of S. pombe is thought to exhert its cell cycle control activity through cellular import of a metabolite.; Function: in S. pombe, Liz1 is required for normal cell division when ribonucleotide reductase is inhibited.; Localization: Liz1 localizes to the plasma membrane of S. pombe.; Phenotype: Inactivation of ribonucleotide reductase causes liz1(-) S. pombe cells in G2 to undergo an aberrant mitosis, resulting in chromosome missegregation and late mitotic arrest.; Remark: the substrate of Liz1 of S. pombe was not yet determined, but it was hypothesized that it could be a metabolite required for uracil biosynthesis.; Similarity: the protein shows strong similarity to a family of putative transmembrane transporters.; Title: strong similarity to transmembrane transporter liz1p - Schizosaccharomyces pombe; plasma membrane; See PMID 9950674; uncharacterized protein 5901 4989597 An18g00030 Aspergillus niger uncharacterized protein XP_059602847.1 3821 D 5061 CDS An18g00040 4989566 join(6777..6892,6953..8378) VIII 1 NT_166533.1 Function: in P. stipitis, Sut1, Sut2 and Sut3 act as glucose transporters with K(m) values in the millimolar range; transport of xylose and other monosaccharides is possible, but with a considerably lower affinity.; Induction: in P. stipitis, Sut2 and Sut3 are only expressed under aerobic conditions, but independent of the carbon source.; Similarity: in P. stipitis three very similar genes called Stu1, Stu2 and Stu3 exist; Stu2 and Stu3 differ by just one amino acid.; Similarity: the gene is closely related to a number of proteins acting as sugar transporters in various fungal species; they all belong to the hexose facilitators family.; Title: strong similarity to sugar transporter Sut2 -Pichia stipitis; plasma membrane; See PMID 10048030; uncharacterized protein 8378 4989566 An18g00040 Aspergillus niger uncharacterized protein XP_001398475.1 6777 D 5061 CDS An18g00050 4989584 join(9321..9737,9789..10649) VIII 1 NT_166533.1 Title: strong similarity to hypothetical protein yraM - Bacillus subtilis; uncharacterized protein 10649 4989584 An18g00050 Aspergillus niger uncharacterized protein XP_059602848.1 9321 D 5061 CDS An18g00060 4989598 complement(join(10794..12463,12530..12861,12915..13000,13134..13175)) VIII 1 NT_166533.1 Similarity: a putative transmembrane domain shows less significant conservation.; Similarity: the N-terminus of the protein contains a putative double-stranded DNA-binding domain characteristic of the GAL4 family of zinc finger proteins.; Similarity: the protein displays similarity to the A. nidulans nirA, and to the N. crassa nit-4 proteins, both involved in the transcriptional regulation of genes involved in nitrogen utilization.; Title: similarity to nitrate assimilation regulatory protein nirA - Aspergillus nidulans; nucleus; See PMID 1922075; uncharacterized protein 13175 4989598 An18g00060 Aspergillus niger uncharacterized protein XP_059602849.1 10794 R 5061 CDS An18g00070 4989596 join(13400..13435,13494..13562,13630..13773,13826..13998,14055..14523) VIII 1 NT_166533.1 Function: CTP1 of S. cerevisiae is a mitochondrial citrate transport protein, member of the mitochondrial carrier family (MCF) of membrane transporters (TC 2. A. 29).; Localization: CTP1 of S. cerevisiae is located in the mitochondrial inner membrane.; Remark: in S. cerevisiae deletion of CTP1 did not lead to a phenotype, suggesting that either known alternative pathways are able to produce sufficient acetyl-CoA, or there exists a second CTP gene.; Remark: no transmembrane regions were predicted for the ORF.; Title: strong similarity to citrate transport protein Ctp1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 7876161; See PMID 8831672; uncharacterized protein 14523 4989596 An18g00070 Aspergillus niger uncharacterized protein XP_001398478.1 13400 D 5061 CDS An18g00080 84593611 complement(join(14764..14804,14892..14982,15060..15232,15325..15425,15494..15747)) VIII 1 NT_166533.1 hypothetical protein 15747 84593611 An18g00080 Aspergillus niger hypothetical protein XP_059602850.1 14764 R 5061 CDS An18g00090 4989585 join(17833..17863,17921..18379,18427..18767) VIII 1 NT_166533.1 Function: adhA in Aspergillus parasiticus is involved in conversion of 5'-hydroxyaverantin to averufin in the synthesis of aflatoxin.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Similarity: the protein shows strong similarity to several mammalian NAD+-dependent 15-hydroxyprostaglandin dehydrogenases.; Title: strong similarity to short-chain alcohol dehydrogenase adhA - Aspergillus parasiticus; See PMID 11055914; uncharacterized protein 18767 4989585 An18g00090 Aspergillus niger uncharacterized protein XP_001398480.1 17833 D 5061 CDS An18g00100 4989586 complement(join(19897..20056,20119..20424,20493..20979,21040..21286)) VIII 1 NT_166533.1 Title: similarity to hypothetical protein PA1213 -Pseudomonas aeruginosa; uncharacterized protein 21286 4989586 An18g00100 Aspergillus niger uncharacterized protein XP_001398481.1 19897 R 5061 CDS An18g00110 4989580 join(22207..23380,23448..23841,23897..24188,24247..24648) VIII 1 NT_166533.1 Title: strong similarity to hypothetical protein EAA61118.1 - Aspergillus nidulans; uncharacterized protein 24648 4989580 An18g00110 Aspergillus niger uncharacterized protein XP_059602851.1 22207 D 5061 CDS An18g00120 4989587 complement(join(25113..26040,26102..26250,26304..26345,26401..26602,26659..26987)) VIII 1 NT_166533.1 Function: in E. coli lysP is a permease that is involved in the transport across the cytoplasmic membrane of lysine.; Induction: in E. coli the activity of lysP increases with growth in acidic medium, anaerobiosis, and high concentrations of lysine.; Localization: in E. coli lysP is an integral membrane protein.; Regulation: in E. coli lysP is inhibited by the lysine analog S-(beta-aminoethyl)-L-cysteine (thiosine).; Similarity: in E. coli lysP belongs to the amino acid permease family.; Title: strong similarity to lysine-specific permease lysP - Escherichia coli; plasma membrane; See PMID 1315732; See PMID 6767681; uncharacterized protein 26987 4989587 An18g00120 Aspergillus niger uncharacterized protein XP_001398483.1 25113 R 5061 CDS An18g00130 84593612 join(27150..27209,27513..27698,27785..27907) VIII 1 NT_166533.1 hypothetical protein 27907 84593612 An18g00130 Aspergillus niger hypothetical protein XP_059602852.1 27150 D 5061 CDS An18g00150 84593613 join(28920..28962,29198..29227,29584..29761,29976..30216) VIII 1 NT_166533.1 hypothetical protein 30216 84593613 An18g00150 Aspergillus niger hypothetical protein XP_059602853.1 28920 D 5061 CDS An18g00170 4989590 complement(join(31844..32729,32810..33225)) VIII 1 NT_166533.1 Title: weak similarity to kinesin - Syncephalastrum racemosum; uncharacterized protein 33225 4989590 An18g00170 Aspergillus niger uncharacterized protein XP_001398487.1 31844 R 5061 CDS An18g00180 84593614 join(33373..33446,33513..33551,33637..33707,33767..33883,33997..34030,34079..34304) VIII 1 NT_166533.1 hypothetical protein 34304 84593614 An18g00180 Aspergillus niger hypothetical protein XP_059602854.1 33373 D 5061 CDS An18g00190 84593615 join(35360..35428,35474..35647) VIII 1 NT_166533.1 hypothetical protein 35647 84593615 An18g00190 Aspergillus niger hypothetical protein XP_059602855.1 35360 D 5061 CDS An18g00200 84593616 join(37027..37274,37653..37797) VIII 1 NT_166533.1 hypothetical protein 37797 84593616 An18g00200 Aspergillus niger hypothetical protein XP_059602856.1 37027 D 5061 CDS An18g00210 84593617 complement(join(40634..41371,41951..42277)) VIII 1 NT_166533.1 Remark: Tan1 is identical to transposon Tndm2 from Aspergillus niger.; Similarity: the Tan1 transposase is homologous to Fusarium oxysporum Fot1 and Magnaporthe grisea Pot2.; Title: similarity to transposase Tan1 - Aspergillus niger; See PMID 9003286; uncharacterized protein 42277 84593617 An18g00210 Aspergillus niger uncharacterized protein XP_059602857.1 40634 R 5061 CDS An18g00230 4989581 join(43343..43601,43667..44307) VIII 1 NT_166533.1 Catalytic activity: Ayr1p catalyzes the NADPH-dependent reduction of 1-acyldihydroxyacetone phosphate.; Localization: Ayr1p is localized in lipid particles and endoplasmic reticulum.; Pathway: Ayr1p catalyzes a step in the phosphatidic acid biosynthesis pathway.; Title: strong similarity to 1-acyldihydroxyacetone-phosphate reductase Ayr1 -Saccharomyces cerevisiae; See PMID 10617610; uncharacterized protein 44307 4989581 An18g00230 Aspergillus niger uncharacterized protein XP_059602858.1 43343 D 5061 CDS An18g00240 4989589 45688..46701 VIII 1 NT_166533.1 Title: strong similarity to dehydrogenase LovC from patent WO200037629-A2 - Aspergillus terreus; uncharacterized protein 46701 4989589 An18g00240 Aspergillus niger uncharacterized protein XP_059602859.1 45688 D 5061 CDS An18g00250 84593618 join(47444..47446,47478..47489,47536..47593,47626..47684) VIII 1 NT_166533.1 hypothetical protein 47684 84593618 An18g00250 Aspergillus niger hypothetical protein XP_059602860.1 47444 D 5061 CDS An18g00260 4989570 complement(join(48831..49184,49292..50431,50503..50550)) VIII 1 NT_166533.1 Function: the avnA gene encodes a fungal cytochrome P-450-type enzyme which is involved in the conversion of averantin to averufin in the aflatoxin biosynthetic pathway in A. parasiticus.; Phenotype: disruption of the avnA gene in the wild-type aflatoxigenic A. parasiticus strain resulted in a nonaflatoxigenic mutant which accumulated a bright yellow pigment.; Remark: at least 17 genes are involved in the aflatoxin biosynthetic pathway of Aspergillus parasiticus.; Title: strong similarity to cytochrome P450 monooxygenase avnA - Aspergillus parasiticus; See PMID 9097431; See PMID 10760564; uncharacterized protein 50550 4989570 An18g00260 Aspergillus niger uncharacterized protein XP_001398495.1 48831 R 5061 CDS An18g00270 84593619 join(51087..51334,51441..51515,51565..51631,51805..51858) VIII 1 NT_166533.1 hypothetical protein 51858 84593619 An18g00270 Aspergillus niger hypothetical protein XP_059602861.1 51087 D 5061 CDS An18g00280 4989571 complement(join(54393..55269,55320..55369)) VIII 1 NT_166533.1 Title: strong similarity to hypothetical protein related to host-specific AK-toxin Akt2 - Neurospora crassa; uncharacterized protein 55369 4989571 An18g00280 Aspergillus niger uncharacterized protein XP_001398497.3 54393 R 5061 CDS An18g00290 4989594 complement(join(56238..56436,56780..56794,56859..57252,57309..57630)) VIII 1 NT_166533.1 Catalytic activity: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP(+) = 3-oxoacyl- [acyl-carrier protein] + NADPH.; Pathway: fabG catalyzes a step in the fatty acid biosynthesis pathway.; Phenotype: insertional inactivation of fabG transcription blocked cell growth, thus providing indication that fabG is an essential gene.; Title: similarity to 3-ketoacyl-(acyl-carrier-protein) reductase fabG -Escherichia coli; See PMID 9642179; See PMID 7592873; uncharacterized protein 57630 4989594 An18g00290 Aspergillus niger uncharacterized protein XP_001398498.3 56238 R 5061 CDS An18g00300 4989595 complement(join(58345..59941,60833..60917,61636..61714)) VIII 1 NT_166533.1 Title: strong similarity to hypothetical protein encoded by An08g05350 - Aspergillus niger; uncharacterized protein 61714 4989595 An18g00300 Aspergillus niger uncharacterized protein XP_059602862.1 58345 R 5061 CDS An18g00320 4989567 join(62247..62324,62388..64136) VIII 1 NT_166533.1 Similarity: similarity corresponds to fungal Zn(2)-Cys(6) binuclear cluster domain (Pfam PF00172).; Title: weak similarity to zinc-finger protein CZF1 -Candida albicans; nucleus; See PMID 1409649; uncharacterized protein 64136 4989567 An18g00320 Aspergillus niger uncharacterized protein XP_001398501.3 62247 D 5061 CDS An18g00330 4989579 join(64354..64513,64582..65444) VIII 1 NT_166533.1 Remark: regulation of the actin cytoskeleton as it is exerted by P. polycephalum actin-fragmin kinase, is essential for diverse cellular processes such as cell division, cell motility and the formation and maintenance of specialized structures in differentiated cells.; Title: similarity to actin-fragmin kinase - Physarum polycephalum; See PMID 8389700; See PMID 8896448; See PMID 10357805; See PMID 10491179; uncharacterized protein 65444 4989579 An18g00330 Aspergillus niger uncharacterized protein XP_001398502.1 64354 D 5061 CDS An18g00340 84593620 complement(join(65494..65572,65678..65821,65865..66349)) VIII 1 NT_166533.1 Similarity: weak similarity to SCOP domain d5rubb1 Ribulose 1,5-bisphosphate carboxylase-oxygenase -Rhodospirillum rubrum; hypothetical protein 66349 84593620 An18g00340 Aspergillus niger hypothetical protein XP_059602863.1 65494 R 5061 CDS An18g00350 84593621 complement(join(66808..66887,67079..67137,67231..67289,67379..67390,67438..67536)) VIII 1 NT_166533.1 hypothetical protein 67536 84593621 An18g00350 Aspergillus niger hypothetical protein XP_059602864.1 66808 R 5061 CDS An18g00360 84593622 join(67892..68128,68216..68227,68307..68474,68565..68650,68740..68980) VIII 1 NT_166533.1 hypothetical protein 68980 84593622 An18g00360 Aspergillus niger hypothetical protein XP_059602865.1 67892 D 5061 CDS An18g00370 4989600 join(69173..69240,69313..69856) VIII 1 NT_166533.1 Title: strong similarity to hypothetical transmembrane protein - Candida albicans; uncharacterized protein 69856 4989600 An18g00370 Aspergillus niger uncharacterized protein XP_001398506.1 69173 D 5061 CDS An18g00380 4989601 join(71244..71485,71561..72070,72149..73013) VIII 1 NT_166533.1 Function: The S. cerevisiae ATR1 gene product permits growth at extremely high concentrations of aminotriazole (80 mM), whereas a chromosomal deletion of ATR1 caused growth inhibition at very low concentrations (5 mM).; Title: strong similarity to aminotriazole resistance protein Atr1 - Saccharomyces cerevisiae; plasma membrane; See PMID 2123132; See PMID 3280970; uncharacterized protein 73013 4989601 An18g00380 Aspergillus niger uncharacterized protein XP_001398507.3 71244 D 5061 CDS An18g00390 4989602 join(73477..74098,74314..74369) VIII 1 NT_166533.1 hypothetical protein 74369 4989602 An18g00390 Aspergillus niger hypothetical protein XP_001398508.3 73477 D 5061 CDS An18g00400 4989603 join(75217..75342,75434..75805,75907..76830) VIII 1 NT_166533.1 Title: similarity to inorganic phosphate transporter PT1 - Nicotiana tabacum; plasma membrane; See PMID 11266109; uncharacterized protein 76830 4989603 An18g00400 Aspergillus niger uncharacterized protein XP_001398509.1 75217 D 5061 CDS An18g00410 4989604 complement(join(77062..77323,77384..77444,77502..77694,77778..78214,78276..78435)) VIII 1 NT_166533.1 Title: similarity to hypothetical protein T22K18.2 -Arabidopsis thaliana; uncharacterized protein 78435 4989604 An18g00410 Aspergillus niger uncharacterized protein XP_059602866.1 77062 R 5061 CDS An18g00420 4989605 join(79525..79639,79703..79811,79869..79984,80059..80301,80359..81182) VIII 1 NT_166533.1 Title: strong similarity to hypothetical neutral amino acid permease - Neurospora crassa; plasma membrane; uncharacterized protein 81182 4989605 An18g00420 Aspergillus niger uncharacterized protein XP_059602867.1 79525 D 5061 CDS An18g00430 4989606 complement(join(81459..81865,81919..81983,82039..82430,82504..82611,82680..82841)) VIII 1 NT_166533.1 Function: the M. grisea PTH11 gene product is presumably involved in host surface recognition and can activate appressorium differentiation in response to inductive surface cues.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529; uncharacterized protein 82841 4989606 An18g00430 Aspergillus niger uncharacterized protein XP_001398512.1 81459 R 5061 CDS An18g00440 4989607 complement(join(83718..83923,83972..84102,84159..84546,84605..84846,84898..85146,85193..85448,85501..85552,85602..85670)) VIII 1 NT_166533.1 Title: strong similarity to monosaccharide transporter AmMst-1 - Amanita muscaria; plasma membrane; See PMID 9487692; uncharacterized protein 85670 4989607 An18g00440 Aspergillus niger uncharacterized protein XP_001398513.1 83718 R 5061 CDS An18g00450 84593623 complement(join(86153..86168,86256..86372,86478..86585,86712..86775,86858..86973,87053..87118,87172..87300,87462..87487,87587..87697,87962..88009,88089..88250,88373..88559,88698..88828)) VIII 1 NT_166533.1 hypothetical protein 88828 84593623 An18g00450 Aspergillus niger hypothetical protein XP_059602868.1 86153 R 5061 CDS An18g00460 4989609 89290..91317 VIII 1 NT_166533.1 Similarity: the encoded protein shows also similarities to E. coli tolB-like proteins.; Title: similarity to protein fragment SEQ ID NO:37063 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 91317 4989609 An18g00460 Aspergillus niger uncharacterized protein XP_001398515.3 89290 D 5061 CDS An18g00470 4989610 complement(join(91474..91682,91737..92210,92248..92335)) VIII 1 NT_166533.1 Similarity: similarity to unnamed ORF AX053132_1 Tremblnew.; Title: strong similarity to sequence 11 from patent WO0073470 - Zea mays; uncharacterized protein 92335 4989610 An18g00470 Aspergillus niger uncharacterized protein XP_059602869.1 91474 R 5061 CDS An18g00480 4989611 join(92870..93053,93117..93790,93901..94704) VIII 1 NT_166533.1 Function: efflux of the toxic drug cycloheximide by H+ antiport (TC 2. A. 1. 2. 2).; Title: strong similarity to cycloheximide resistance protein CYHR - Candida maltosa; plasma membrane; See PMID 1628836; uncharacterized protein 94704 4989611 An18g00480 Aspergillus niger uncharacterized protein XP_059602870.1 92870 D 5061 CDS An18g00490 4989612 complement(join(96695..96718,96830..96937,97050..97751)) VIII 1 NT_166533.1 Catalytic activity: salicylate + NADH + O2 = catechol + NAD+ + H2O + CO2.; Function: nahG of P. stutzeri catalyzes the formation of catechol from salicylate, a key intermediate in naphthalene catabolism.; Induction: nahG of P. stutzeri is induced and expressed upon incubation with salicylate.; Pathway: nahpthalene, salicylate, and phenylalanine metabolism.; Similarity: the ORF is shorter than nahG of P. stutzeri (277 compared to 437 amino acids).; Title: similarity to salicylate hydroxylase nahW -Pseudomonas stutzeri; See PMID 10197990; See PMID 10433976; See PMID 10713446; uncharacterized protein 97751 4989612 An18g00490 Aspergillus niger uncharacterized protein XP_059602871.1 96695 R 5061 CDS An18g00500 4989613 complement(join(98674..99222,99297..99872,99942..100181,100418..100502,100634..100674)) VIII 1 NT_166533.1 Catalytic activity: catalyses the 14 alpha-demethylation of obtusifoliol to 4 alpha-methyl-5 alpha-ergosta-8, 14,24(28)-trien-3 beta-ol as evidenced by GC-MS.; Function: CYP51s catalyses in all eukaryotes the 14alpha-demethylation of sterols.; Remark: the S. bicolor cytochrome CYP51 gene product is a P450 orthologous to the sterol 14 alpha-demethylases (CYP51) from fungi and mammals.; Similarity: CYP51s form the only family of P450 proteins conserved in evolution from prokaryotes to fungi,plants and mammals.; Title: strong similarity to obtusifoliol 14-alpha demethylase CYP51 - Sorghum bicolor; See PMID 9076987; See PMID 10336628; uncharacterized protein 100674 4989613 An18g00500 Aspergillus niger uncharacterized protein XP_001398519.3 98674 R 5061 CDS An18g00510 4989614 join(102163..102300,102362..103636) VIII 1 NT_166533.1 Catalytic activity: (D)-6-hydroxynicotine + H(2)o + o(2) = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H(2)o(2).; Pathway: degradation of nicotine (inducible).; Similarity: similarity to other oxygen oxidoreductases that covalently bind FAD.; Title: similarity to 6-hydroxy-d-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 2115879; See PMID 2680607; See PMID 3905431; uncharacterized protein 103636 4989614 An18g00510 Aspergillus niger uncharacterized protein XP_001398520.1 102163 D 5061 CDS An18g00520 4989615 join(104963..105025,105099..113846,113931..116702) VIII 1 NT_166533.1 Function: the C. heterostrophus PKS1 gene product is a multifunctional polyketide synthase with six catalytic domains: beta-ketoacyl synthase, acyltransferase,dehydratase, enoyl reductase, beta-ketoacyl reductase, and acyl carrier protein involved in production of T-toxin.; Title: strong similarity to polyketide synthase PKS1 - Cochliobolus heterostrophus; See PMID 8953776; uncharacterized protein 116702 4989615 An18g00520 Aspergillus niger uncharacterized protein XP_059602872.1 104963 D 5061 CDS An18g00530 4989616 join(117780..118142,118228..118269,118351..119251,119316..119768,119846..119908,119966..120057) VIII 1 NT_166533.1 Catalytic activity: versicolorin B synthase of A. parasiticus catalyzes the side chain cyclization of racemic versiconal hemiacetal to the bisfuran ring system of versicolorin B.; Pathway: versicolorin B synthase catalyzes an essential transformation in the aflatoxin biosynthetic pathway of A. parasiticus.; Remark: vbs of A. parasiticus possesses an amino-terminal sequence homologous to the ADP-binding region of other flavoenzymes; however, this enzyme does not require flavin or nicotinamide cofactors for its cyclase activity.; Similarity: the predicted ORF shows strong similarity also to other oxidureductases of different specificity.; Title: strong similarity to versicolorin B synthase vbs - Aspergillus parasiticus; See PMID 8662689; See PMID 10855719; uncharacterized protein 120057 4989616 An18g00530 Aspergillus niger uncharacterized protein XP_001398522.1 117780 D 5061 CDS An18g00540 4989617 complement(join(120818..121450,121526..125094,125232..125385)) VIII 1 NT_166533.1 Function: alpha-latrotoxin is the major component of black widow spider venom, and is particularly studied for its effects on a variety of neurosecretory cells.; Function: alpha-latrotoxin triggers a massive exocytosis in the target cells, both due to calcium influx via specifically-induced channels, and due to the binding to other calcium-independent receptors.; Similarity: the N-terminal half of the predicted ORF shows an equally good similarity to B24M22. 200 of N. crassa, an hypothetical protein related to small s protein.; Similarity: the predicted ORF contains two ankyrin repeats.; Similarity: the similarity to the alpha-latrotoxin precursor of L. tredecimguttatus involves the C-terminal half of the predicted ORF.; Title: similarity to precursor of alpha-latrotoxin -Latrodectus tredecimguttatus; extracellular/secretion proteins; See PMID 9799228; See PMID 10382267; uncharacterized protein 125385 4989617 An18g00540 Aspergillus niger uncharacterized protein XP_001398523.3 120818 R 5061 CDS An18g00550 4989618 complement(join(125596..125909,125972..126438,126507..126630,126699..126825,126891..127058)) VIII 1 NT_166533.1 Catalytic activity: S-adenosyl-L-methionine + 6-demethylsterigmatocystin = S-adenosyl-L-homocysteine + sterigmatocystin.; Catalytic activity: dihydromethylsterigmatocystin can also act as methyl acceptor, and the product of the reaction is dihydrosterigmatocystin.; Pathway: in A. parasiticus omtB-dmtA catalyzes a crucial step in the biosynthesis of aflatoxins.; Remark: the purification and biochemical characterization of dmtA of A. parasiticus are described in a journal article not indexed by PubMed: Appl Environ Microbiol, January 1998, p. 166-171, Vol. 64, No. 1.; Similarity: omtB of A. parasiticus is almost identical to dmtA (also known as MT-I) of the same organism.; Similarity: the predicted ORF shows strong similarity also to several methyltransferases with different specificities.; Title: strong similarity to O-methyltransferase B omtB - Aspergillus parasiticus; cytoplasm; See PMID 10543813; See PMID 10806361; uncharacterized protein 127058 4989618 An18g00550 Aspergillus niger uncharacterized protein XP_001398524.1 125596 R 5061 CDS An18g00560 84593624 complement(join(127071..127255,127282..127325,127513..127670,128010..128229,128496..128633,128716..128852,128940..129033,129130..129188)) VIII 1 NT_166533.1 Similarity: the similarity to fixR homolog of A. tumefaciens involves only the N-terminal half of the predicted ORF.; Title: weak similarity to hypothetical fixR homolog - Agrobacterium tumefaciens; uncharacterized protein 129188 84593624 An18g00560 Aspergillus niger uncharacterized protein XP_059602873.1 127071 R 5061 CDS An18g00570 4989620 join(129772..129821,129880..130016,130064..130118,130170..130770) VIII 1 NT_166533.1 Title: similarity to hypothetical protein CAD36967.1 - Neurospora crassa; uncharacterized protein 130770 4989620 An18g00570 Aspergillus niger uncharacterized protein XP_001398526.3 129772 D 5061 CDS An18g00580 84593625 complement(join(131350..131495,131549..131615)) VIII 1 NT_166533.1 hypothetical protein 131615 84593625 An18g00580 Aspergillus niger hypothetical protein XP_059602874.1 131350 R 5061 CDS An18g00590 84593626 join(131778..131863,131990..132061,132240..132333,132530..>132724) VIII 1 NT_166533.1 Remark: C-terminally truncated ORF due to contig border.; hypothetical protein [truncated ORF] 132724 84593626 An18g00590 Aspergillus niger hypothetical protein [truncated ORF] XP_059602875.1 131778 D 5061 CDS An18g00600 4989623 <132853..133296 VIII 1 NT_166533.1 Localization: the association of hsp30 of N. crassa with mitochondria is reversible and hsp30 dissociates after cells are returned to normal temperature.; Phenotype: disruption of hsp30 in N. crassa causes extreme sensitivity to the combination of temperature stress and carbohydrate limitation, suggesting that hsp30 may be important for efficient carbohydrate utilization during high temperature stress.; Remark: N-terminally truncated ORF due to contig border.; Similarity: hsp30 of N. crassa is related to the alpha-crystallin/Hsp20 family; Similarity: the predicted ORF shows stronger similarity to HSP30 of A. nidulans, which was not functionally characterized.; Title: strong similarity to heat shock protein hsp30 - Neurospora crassa [truncated ORF]; localisation:mitochondrion; See PMID 2144284; See PMID 7761443; uncharacterized protein 133296 4989623 An18g00600 Aspergillus niger uncharacterized protein XP_001398529.1 132853 D 5061 CDS An18g00620 4989625 complement(join(134509..134627,134674..135226)) VIII 1 NT_166533.1 Function: gamma-TIP of A. thaliana is a water-specific channel of the vacuolar membrane; it may play a role in the control of cell turgor and cell expansion.; Induction: gamma-TIP of A. thaliana is induced by gibberellins.; Similarity: gamma-TIP of A. thaliana belongs to the transmembrane channel major intrinsic protein (MIP) family,comprising water and small neutral solutes (e. g. glycerol) transporters.; Title: similarity to tonoplast intrinsic protein TIP-gamma - Arabidopsis thaliana; vacuole; See PMID 8155880; See PMID 8508761; uncharacterized protein 135226 4989625 An18g00620 Aspergillus niger uncharacterized protein XP_059602876.1 134509 R 5061 CDS An18g00630 4989626 complement(join(136091..136326,136391..136698,136777..137033,137096..137119)) VIII 1 NT_166533.1 hypothetical protein 137119 4989626 An18g00630 Aspergillus niger hypothetical protein XP_001398531.1 136091 R 5061 CDS An18g00640 84593627 join(137371..137480,137631..137919) VIII 1 NT_166533.1 hypothetical protein 137919 84593627 An18g00640 Aspergillus niger hypothetical protein XP_059602877.1 137371 D 5061 CDS An18g00650 84593628 join(137930..138056,138435..138692,138800..138918,139220..139253,139355..139579,139767..139834) VIII 1 NT_166533.1 Remark: the structure of the gene is questionable.; Title: weak similarity to hypothetical protein AAA73346.1 - Mycobacterium tuberculosis; uncharacterized protein 139834 84593628 An18g00650 Aspergillus niger uncharacterized protein XP_059602878.1 137930 D 5061 CDS An18g00660 4989629 complement(140490..141239) VIII 1 NT_166533.1 Catalytic activity: S-Adenosyl-L-methionine is used as the methyl-group donor.; Function: CCoAOMT of N. tabacum is involved in the biosynthesis of lignin.; Similarity: the predicted ORF is partially identical to A. niger EST EMBLEST Acc. BE758937.; Similarity: the predicted ORF shows strong similarity or similarity to a huge number of putative or characterized O-methyltransferases of bacterial, fungal or plant origin, with different specificities and functions.; Title: similarity to caffeoyl-CoA O-methyltransferase CCoAOMT-1 - Nicotiana tabacum; See PMID 9484483; uncharacterized protein 141239 4989629 An18g00660 Aspergillus niger uncharacterized protein XP_001398534.1 140490 R 5061 CDS An18g00670 4989630 join(142131..142720,142785..144111) VIII 1 NT_166533.1 Title: weak similarity to p45 NF-E2 related factor 2 NRF2 - Mus musculus; See PMID 8943040; uncharacterized protein 144111 4989630 An18g00670 Aspergillus niger uncharacterized protein XP_001398535.1 142131 D 5061 CDS An18g00680 4989631 complement(join(145268..145654,145824..145902,145983..146131)) VIII 1 NT_166533.1 hypothetical protein 146131 4989631 An18g00680 Aspergillus niger hypothetical protein XP_001398536.3 145268 R 5061 CDS An18g00690 4989632 join(146763..146771,147089..147149,147463..147707,147800..148378) VIII 1 NT_166533.1 Title: similarity to hypothetical esterase SCD10.24 - Streptomyces coelicolor; uncharacterized protein 148378 4989632 An18g00690 Aspergillus niger uncharacterized protein XP_001398537.3 146763 D 5061 CDS An18g00700 4989633 join(149300..149844,149895..149951,150018..150198,150255..150478,150557..150700,150753..150809,150868..151001,151066..151138,151193..151250) VIII 1 NT_166533.1 Function: in S. cerevisiae FLR1 confers resistance to cerulenin, benomyl, methotrexate and diazaborine.; Function: multidrug transporters are membrane proteins which, by an unknown mechanism, recognize diverse toxic compounds and efflux them from cells.; Induction: FLR1 of S. cerevisiae is dramatically induced by AP-1 and PDR3, two transcription factors known to mediate cellular resistance to toxicants.; Remark: FLR1 of S. cerevisiae is also known as YBR008C.; Similarity: the predicted ORF and FLR1 of S. cerevisiae show strong similarity to known and hypothetical members of the multidrug efflux transporters belonging to the major facilitator superfamily of transport proteins.; Title: strong similarity to fluconazole resistance transporter Flr1 - Saccharomyces cerevisiae; plasma membrane; See PMID 9235926; See PMID 10102370; See PMID 10572257; See PMID 10903515; uncharacterized protein 151250 4989633 An18g00700 Aspergillus niger uncharacterized protein XP_001398538.1 149300 D 5061 CDS An18g00710 84593629 complement(join(151623..151817,151897..152248,152318..152652,152711..152893)) VIII 1 NT_166533.1 Title: strong similarity to hypothetical protein CGA009 - Rhodopseudomonas palustris; uncharacterized protein 152893 84593629 An18g00710 Aspergillus niger uncharacterized protein XP_059602879.1 151623 R 5061 CDS An18g00720 84593630 complement(join(153257..153409,153781..153882,153952..154037,154531..154645,154714..154800)) VIII 1 NT_166533.1 Title: questionable ORF; uncharacterized protein 154800 84593630 An18g00720 Aspergillus niger uncharacterized protein XP_059602880.1 153257 R 5061 CDS An18g00730 4989636 155421..156713 VIII 1 NT_166533.1 Function: CAP59, as well as the other two capsule-associated proteins CAP60 and CAP64, are essential for the formation or the stabilization of the capsule in C. neoformans.; Function: the polysaccharide capsule is one of the most important virulence factors for the pathogenic fungus C. neoformans.; Similarity: the similarity to CAP59 of C. neoformans does not involve the N-terminal region of the two proteins.; Title: strong similarity to capsule-associated protein CAP59 - Cryptococcus neoformans; cell wall; See PMID 8007987; See PMID 9573112; uncharacterized protein 156713 4989636 An18g00730 Aspergillus niger uncharacterized protein XP_001398541.1 155421 D 5061 CDS An18g00740 4989637 join(157327..157582,157672..158155,158220..158803,158862..159388) VIII 1 NT_166533.1 hypothetical protein 159388 4989637 An18g00740 Aspergillus niger hypothetical protein XP_001398542.1 157327 D 5061 CDS An18g00750 4989638 join(160310..160401,160456..160681,160737..160793,160825..161163,161219..161392,161444..161545) VIII 1 NT_166533.1 Title: similarity to diagnostic protein #11744 from patent WO200175067-A2 - Homo sapiens; uncharacterized protein 161545 4989638 An18g00750 Aspergillus niger uncharacterized protein XP_059602881.1 160310 D 5061 CDS An18g00760 84593631 complement(join(161814..162070,162155..162196,162296..162317)) VIII 1 NT_166533.1 Function: many ankyrin repeat regions are known to function as protein-protein interaction domains.; Remark: human tankyrases have been patented by various companies: see patents WO104326, WO100849,WO9964606.; Similarity: ankyrin repeats (ANK) are tandemly repeated modules of about 33 amino acids, that occur in a large number of functionally diverse proteins mainly from eukaryotes.; Similarity: the predicted ORF shows similarity also to the ZU5 domain present in ZO-1 and Unc5-like netrin receptors, which function remains unknown.; Similarity: the similarity to tankyrase of H. sapiens and other proteins is mainly due to the presence of an ankyrin repeat.; Title: weak similarity to TRF1-interacting ankyrin-related ADP-ribose polymerase tankyrase - Homo sapiens; See PMID 9822378; uncharacterized protein 162317 84593631 An18g00760 Aspergillus niger uncharacterized protein XP_059602882.1 161814 R 5061 CDS An18g00790 4989640 162431..166843 VIII 1 NT_166533.1 Title: strong similarity to retrotransposon Tto1 -Nicotiana tabacum; See PMID 8624443; uncharacterized protein 166843 4989640 An18g00790 Aspergillus niger uncharacterized protein XP_001398545.1 162431 D 5061 CDS An18g00810 4989641 join(168055..168102,168165..168309,168368..168942) VIII 1 NT_166533.1 Function: the function of frnE of Streptomyces is unknown.; Localization: frnE of Streptomyces is not membrane-bound.; Remark: frenolicin B is an antibiotic used as an anticoccidial agent.; Remark: frnE of Streptomyces belongs to the frenolicin gene cluster.; Title: similarity to frenolicin gene E product frnE from patent EP806480-A2 - Streptomyces sp.; uncharacterized protein 168942 4989641 An18g00810 Aspergillus niger uncharacterized protein XP_001398546.1 168055 D 5061 CDS An18g00820 4989642 complement(join(169067..169278,169335..169851)) VIII 1 NT_166533.1 Similarity: the predicted ORF is partially identical to A. niger EST EMBLEST Acc. BE759903.; Similarity: the predicted ORF shows similarity or weak similarity to some putative O-methyltransferases, and contains some structural features common to such class of enzymes.; Title: strong similarity to hypothetical mll5689 -Mesorhizobium loti; uncharacterized protein 169851 4989642 An18g00820 Aspergillus niger uncharacterized protein XP_001398547.1 169067 R 5061 CDS An18g00830 84593632 join(169916..170029,170085..170513) VIII 1 NT_166533.1 Title: weak similarity to EST an_2841 - Aspergillus niger; uncharacterized protein 170513 84593632 An18g00830 Aspergillus niger uncharacterized protein XP_059602883.1 169916 D 5061 CDS An18g00840 4989644 complement(join(170686..170856,171026..171100,171161..171529)) VIII 1 NT_166533.1 Remark: TrpG of patent WO9806734-A1 is identical to trpG protein of Corynebacterium glutamicum, a putative protein predicted to have glutamine amidotransferase activity.; Similarity: the predicted ORF shows much stronger similarities to B. carinata, S. pombe, and A. thaliana hypothetical proteins.; Title: similarity to protein CJAS1 from patent WO200263018-A2 - Brassica napus; uncharacterized protein 171529 4989644 An18g00840 Aspergillus niger uncharacterized protein XP_001398549.3 170686 R 5061 CDS An18g00850 4989645 172154..172942 VIII 1 NT_166533.1 Phenotype: null mutation of paiB in B. subtilis is lethal.; Remark: in B. subtilis paiB is the second ORF of the pai operon, involved in negative control of sporulation and degradative-enzyme production.; Title: similarity to transcription regulator paiB -Bacillus subtilis; See PMID 2108124; uncharacterized protein 172942 4989645 An18g00850 Aspergillus niger uncharacterized protein XP_001398550.1 172154 D 5061 CDS An18g00860 4989646 173166..174878 VIII 1 NT_166533.1 Function: pro1 is essential in S. macrospora for the formation of multicellular fruiting bodies called perithecia.; Similarity: the N-terminal region of the predicted ORF contains a fungal Zn(2)-Cys(6) binuclear cluster domain, a cysteine-rich region that binds DNA, and is found in many fungal transcriptional activators.; Similarity: the similarity to pro1 of S. macrospora is only due to the conserved fungal zinc-finger motiv.; Title: similarity to zinc-finger transcription factor pro1 - Sordaria macrospora; See PMID 10224253; uncharacterized protein 174878 4989646 An18g00860 Aspergillus niger uncharacterized protein XP_059602884.1 173166 D 5061 CDS An18g00870 4989647 complement(175819..176874) VIII 1 NT_166533.1 Catalytic activity: 2,3-dihydroxybenzoate = catechol + co(2).; Complex: O-pyrocatechuate decarboxylase of A. niger is a homotetramer.; Pathway: last step in the metabolism of indole to catechol.; Remark: the catalytic active site of O-pyrocatechuate decarboxylase of A. niger was characterized and it is not conserved in the predicted ORF.; Remark: the gene for O-pyrocatechuate decarboxylase of A. niger was not yet cloned; the database entries are derived from peptide mapping experiments.; Title: similarity to O-pyrocatechuate decarboxylase - Aspergillus niger; See PMID 7601088; uncharacterized protein 176874 4989647 An18g00870 Aspergillus niger uncharacterized protein XP_001398552.1 175819 R 5061 CDS An18g00880 4989648 join(177884..178366,178415..178705) VIII 1 NT_166533.1 Catalytic activity: dihydrofolate reductase catalyzes the reaction: 5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.; Pathway: dihydrofolate reductase catalyzes essential steps for de novo glycine and purine synthesis and for the conversion of dUMP to dTMP.; Similarity: the similarity to dfr1 of S. pombe involves the C-terminal part of the predicted ORF and the N-terminal part of the dihydrofolate reductase enzyme.; Title: similarity to dihydrofolate reductase dfr1p -Schizosaccharomyces pombe; See PMID 8088538; uncharacterized protein 178705 4989648 An18g00880 Aspergillus niger uncharacterized protein XP_059602885.1 177884 D 5061 CDS An18g00890 84593633 complement(179398..180969) VIII 1 NT_166533.1 hypothetical protein 180969 84593633 An18g00890 Aspergillus niger hypothetical protein XP_059602886.1 179398 R 5061 CDS An18g00900 4989650 join(181815..181930,182055..182122,182179..182239,182307..182327,182381..182426) VIII 1 NT_166533.1 Catalytic activity: cis-trans isomerization of proline imidic peptide bonds in oligopeptides.; Function: peptidyl-prolyl cis-trans isomerases (PPIases) accelerate the folding of proteins.; Remark: FPR1 of S. cerevisiae is also called FKB1,RBP1 or YNL135C.; Remark: FPR1 of S. cerevisiae is the molecular target of the immunosuppressant drug FK506 and also mediates the sensitivity to rapamycin.; Similarity: FPR1 belongs to the FKBP-type PPIase family; these proteins share common structural and functional features with the cyclophilins, but these last are responsive to heat shock.; Title: strong similarity to peptidyl-prolyl isomerase Fpr1 - Saccharomyces cerevisiae; cytoplasm; See PMID 1701173; See PMID 1704127; See PMID 7685914; uncharacterized protein 182426 4989650 An18g00900 Aspergillus niger uncharacterized protein XP_059602887.1 181815 D 5061 CDS An18g00910 4989651 complement(join(182689..183009,183113..183490)) VIII 1 NT_166533.1 Catalytic activity: salE of Acinetobacter have esterase activity against short-chain alkyl esters of 4-nitrophenol but is also able to hydrolyze ethyl salicylate to ethanol and salicylic acid.; Phenotype: salE mutants of Acinetobacter lose the ability to utilize only ethyl and methyl salicylates of the esters tested as sole carbon sources.; Similarity: the predicted ORF is partially identical to A. niger EST EMBLEST Acc. BE759031.; Title: similarity to alkyl salicylate esterase salE - Acinetobacter sp.; See PMID 10715011; uncharacterized protein 183490 4989651 An18g00910 Aspergillus niger uncharacterized protein XP_001398556.1 182689 R 5061 CDS An18g00920 84593634 join(183685..183969,184061..184189) VIII 1 NT_166533.1 hypothetical protein 184189 84593634 An18g00920 Aspergillus niger hypothetical protein XP_059604966.1 183685 D 5061 CDS An18g00940 4989654 complement(join(184885..184917,184969..185458,185511..185819,185873..186243,186604..186687)) VIII 1 NT_166533.1 Catalytic activity: L-sorbose + acceptor <=> 5-dehydro-D-fructose + reduced acceptor.; Cofactor: FAD.; Title: strong similarity to FAD dependent L-sorbose dehydrogenase SDH - Gluconobacter oxydans; See PMID 9023923; uncharacterized protein 186687 4989654 An18g00940 Aspergillus niger uncharacterized protein XP_001398558.3 184885 R 5061 CDS An18g00950 4989655 complement(join(187432..187766,187845..188167,188322..188419)) VIII 1 NT_166533.1 Title: weak similarity to hypothetical acetyltransferase MK0549 - Methanopyrus kandle; uncharacterized protein 188419 4989655 An18g00950 Aspergillus niger uncharacterized protein XP_001398559.1 187432 R 5061 CDS An18g00960 4989656 complement(join(188856..189100,189137..189308,189390..189719,189784..189803,189869..190246,190318..190390,190444..190543,190893..191023)) VIII 1 NT_166533.1 Function: Hnm1 of S. cerevisiae is the unique coline permease in yeast (Km of 0. 5 micromolar).; Regulation: in S. cerevisiae, expression of HNM1 gene is regulated by the phospholipid precursors inositol and choline and this regulation involves the trans-acting factors Ino2p, Ino4p and Opi1p.; Remark: alternate name for S. cerevisiae Hnm1 is YGL077c.; Similarity: Hnm1 of S. cerevisiae belongs to the APC family, which encompasses amino acid permeases more related to the mammalian cationic amino-acid transporter family (Tea/ecoR).; Title: strong similarity to choline permease Hnm1 -Saccharomyces cerevisiae; plasma membrane; See PMID 7520996; See PMID 8264542; See PMID 2203793; uncharacterized protein 191023 4989656 An18g00960 Aspergillus niger uncharacterized protein XP_059604967.1 188856 R 5061 CDS An18g00970 84593635 complement(join(191414..191926,192024..192059)) VIII 1 NT_166533.1 Title: weak similarity to hypothetical protein BAA96207.1 - Oryza sativa; uncharacterized protein 192059 84593635 An18g00970 Aspergillus niger uncharacterized protein XP_059604968.1 191414 R 5061 CDS An18g00980 4989658 join(192265..192408,192474..192800,192858..193000,193050..193344) VIII 1 NT_166533.1 Function: M. grisea Pth11 is a pathogenicity gene.; Function: M. grisea Pth11p is likely to be involved in host surface recognition.; Function: M. grisea pth11 mutants of strain 4091-5-8 are nonpathogenic due to a defect in appressorium differentiation.; Localization: in M. grisea, a Pth11-green fluorescent protein fusion localised to the cell membrane and vacuoles.; Similarity: similarity of the predicted A. niger protein and M. grisea Pth11 is limited to the N-terminal half of the protein sequences.; Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529; uncharacterized protein 193344 4989658 An18g00980 Aspergillus niger uncharacterized protein XP_001398562.1 192265 D 5061 CDS An18g00990 4989659 complement(193431..193571) VIII 1 NT_166533.1 Title: strong similarity to EST an_1359 -Aspergillus niger; uncharacterized protein 193571 4989659 An18g00990 Aspergillus niger uncharacterized protein XP_001398563.1 193431 R 5061 CDS An18g01000 4989660 join(194144..194393,194456..194685,194749..195123) VIII 1 NT_166533.1 Similarity: the nucleotide sequence of the ORF shows strong similarity to the ESTs an_2192 and an_2204 of A. niger.; Title: strong similarity to EST an_2192 -Aspergillus niger; uncharacterized protein 195123 4989660 An18g01000 Aspergillus niger uncharacterized protein XP_001398564.1 194144 D 5061 CDS An18g01010 4989661 join(195624..195781,195842..197108) VIII 1 NT_166533.1 Function: FLU1 of C. albicans facilitates resistance to fluconazole and cycloheximide in the fluconazole-hypersensitive S. cerevisiae strain YKKB-13 lacking the ABC (ATP-binding cassette) transporter gene PDR5.; Function: FLU1 of C. albicans facilitates resistance to mycophenolic acid in C. albicans.; Function: FLU1 of C. albicans is involved in the resistance to azol derivatives in C. albicans.; Function: MDR1 of C. albicans facilitates resistance to the anti-mitotic drug benomyl and to the dihydrofolate reductase inhibitor methotrexate.; Similarity: N-terminus of the A. niger protein is app. 120 aa shorter than in FLU1 of C. albicans.; Similarity: the predicted A. niger protein shows strong similarity to fluconazole resistance protein FLU1of C. albicans, which is a permease belonging to the major facilitator superfamily.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353; uncharacterized protein 197108 4989661 An18g01010 Aspergillus niger uncharacterized protein XP_001398565.1 195624 D 5061 CDS An18g01020 4989662 complement(join(197673..197962,198055..198489,198561..198816)) VIII 1 NT_166533.1 Complex: the estimated molecular mass of the purified gentisate 1, 2-dioxygenase of P. alcaligenes was 154 kDa, with a subunit mass of 39 kDa. its structure is deduced to be a tetramer.; Remark: gentisate 1,2-dioxygenase of P. alcaligenes exhibits typical saturation kinetics and has an apparent Km of 92 microM for gentisate. this enzyme has broad substrate specificities towards alkyl and halogenated gentisate analogs.; Similarity: the predicted A. niger protein shows strong similarity to gentisate 1,2-dioxygenase of P. alcaligenes and conserved hypothetical proteins from other procaryotic species.; Title: strong similarity to gentisate 1,2-dioxygenases xlnE - Pseudomonas alcaligenes; See PMID 10049846; uncharacterized protein 198816 4989662 An18g01020 Aspergillus niger uncharacterized protein XP_059604969.1 197673 R 5061 CDS An18g01030 4989663 join(199258..199305,199367..199925,199991..200147,200228..200383,200447..200586,200678..201036) VIII 1 NT_166533.1 Function: Mak1 from N. haematococca specifically hydroxylates the phytoalexins medicarpin and maackiain,converting them to less fungitoxic derivatives.; Localization: heterologous expression of the Mak1 cDNA construct in plants indicated that Mak1 protein accumulates in the plant cytoplasm, associated with endoplasmic reticulum membranes.; Similarity: the predicted A. niger protein shows strong similarity to Mak1 from the fungal pathogen N. haematococca. Mak1 belongs to the flavin-containing mono-oxygenases. best matches are with putative salicylate hydroxylases of several procaryotic species.; Title: strong similarity to maackiain detoxification protein 1 MAK1 - Nectria haematococca; endoplasmatic reticulum; See PMID 8709942; See PMID 11485199; uncharacterized protein 201036 4989663 An18g01030 Aspergillus niger uncharacterized protein XP_001398567.1 199258 D 5061 CDS An18g01040 4989664 join(201410..201508,201583..201683,201752..201987,202042..202807,203017..203579,203681..203896,203969..204135) VIII 1 NT_166533.1 Phenotype: facB recessive loss of function mutants in A. nidulans are deficient in acetate induction of acetyl-CoA synthase, isocitrate lyase, malate synthase,acetamidase, and NADP-isocitrate dehydrogenase.; Similarity: the predicted A. niger protein shows similarity to acetate regulatory DNA binding protein FacB (facB) from A. nidulans, which belongs to the GAL4-type zinc cluster transcriptional activators.; Title: similarity to acetate regulatory DNA binding protein facB - Aspergillus nidulans; See PMID 9197408; uncharacterized protein 204135 4989664 An18g01040 Aspergillus niger uncharacterized protein XP_059604970.1 201410 D 5061 CDS An18g01050 4989665 complement(join(204417..205088,205145..205282,205354..205763,205824..205947,206014..206199)) VIII 1 NT_166533.1 Catalytic activity: lignostilbene-alpha,beta-dioxygenase isozymes (LSD-I, II, and III) of P. paucimobilis catalyse the reaction 1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O(2) = 2 vanillin; Cofactor: lignostilbene-alpha,beta-dioxygenase isozymes (LSD-I, II, and III) of P. paucimobilis require iron as a cofactor.; Complex: LSD-I, II, and III consist of alpha alpha,alpha beta, and beta beta subunits, respectively. they show different specificities for several substrates that are stilbene and styrene derivatives.; Function: LSD of P. paucimobilis catalyses the oxidative cleavage of the interphenyl double bond in the synthetic substrate and lignin-derived stilbenes. it is responsible for the degradation of a diarylpropane-type structure in lignin.; Similarity: the predicted A. niger protein shows strong similarity to subunit lsdB of lignostilbene-alpha,beta-dioxygenase isozyme LSD-III of P. paucimobilis and related dioxygenases from several plant species.; Title: strong similarity to subunit lsdB of lignostilbene-alpha,beta-dioxygenase isozyme LSD-III -Pseudomonas paucimobilis; See PMID 7763880; See PMID 8534977; uncharacterized protein 206199 4989665 An18g01050 Aspergillus niger uncharacterized protein XP_059604971.1 204417 R 5061 CDS An18g01060 4989666 join(206740..207019,207087..207215,207311..207696) VIII 1 NT_166533.1 Catalytic activity: 5-carboxymethyl-2-hydroxymuconate delta-isomerase from E. coli catalyses the reaction 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate.; Pathway: 5-carboxymethyl-2-hydroxymuconate delta-isomerase from E. coli is involved in tyrosine and phenylalanine metabolism.; Similarity: the predicted A. niger protein shows strong similarity to 5-carboxymethyl-2-hydroxymuconate delta-isomerase from E. coli and many putative 2-hydroxyhepta-2,4-diene-1, 7-dioate isomerases from several procaryotic and eucaryotic organisms.; Title: strong similarity to 5-carboxymethyl-2-hydroxymuconate delta-isomerase -Escherichia coli; cytoplasm; See PMID 8223600; uncharacterized protein 207696 4989666 An18g01060 Aspergillus niger uncharacterized protein XP_059604972.1 206740 D 5061 CDS An18g01070 4989667 join(208628..208702,208810..208945,209208..209389,209456..209647,209724..209788,209850..210290,210366..210947,211067..211070) VIII 1 NT_166533.1 Function: FLU1 of C. albicans facilitates resistance to fluconazole and cycloheximide in the fluconazole-hypersensitive S. cerevisiae strain YKKB-13 lacking the ABC (ATP-binding cassette) transporter gene PDR5.; Function: FLU1 of C. albicans facilitates resistance to mycophenolic acid in C. albicans.; Function: FLU1 of C. albicans is involved in the resistance to azol derivatives in C. albicans.; Function: MDR1 of C. albicans facilitates resistance to the anti-mitotic drug benomyl and to the dihydrofolate reductase inhibitor methotrexate.; Similarity: N-terminus of the A. niger protein is app. 120 aa shorter than in FLU1 of C. albicans.; Similarity: the predicted A. niger protein shows strong similarity to fluconazole resistance protein FLU1of C. albicans, which is a permease belonging to the major facilitator superfamily.; Title: similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353; uncharacterized protein 211070 4989667 An18g01070 Aspergillus niger uncharacterized protein XP_001398571.3 208628 D 5061 CDS An18g01080 84593636 complement(join(211441..211864,211903..211986,212094..212194,212246..212311)) VIII 1 NT_166533.1 hypothetical protein 212311 84593636 An18g01080 Aspergillus niger hypothetical protein XP_059604973.1 211441 R 5061 CDS An18g01090 4989669 join(212518..213327,213380..213519,213569..214481) VIII 1 NT_166533.1 Catalytic activity: lysophospholipase catalyses the reaction 2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a fatty acid anion.; Pathway: lysophospholipase is involved in phospholipid degradation.; Similarity: the predicted A. niger protein shows strong similarity to the protein sequences lysophospholipase (sequence 5 and sequence 7) of patents WO0127251-A/5 and WO0127251-A/7 from A. oryzae (AC# AX112082 and AC# AX112084) and to other fungal lysophospholipases.; Title: strong similarity to lysophospholipase from patent WO0127251-A - Aspergillus oryzae; extracellular/secretion proteins; See PMID 1722456; uncharacterized protein 214481 4989669 An18g01090 Aspergillus niger uncharacterized protein XP_001398573.1 212518 D 5061 CDS An18g01100 4989670 complement(join(214604..214689,214725..214864,214917..215274,215346..215862)) VIII 1 NT_166533.1 Remark: the patent does not provide further information about the function of the protein.; Similarity: the predicted A. niger protein shows strong similarity to the protein sequence alcohol dehydrogenase (sequence 19) of patent EP0845532-A/19 from an unclassified organism (AC# A92108) and to other zinc-containing dehydrogenases.; Title: strong similarity to alcohol dehydrogenase from patent EP0845532-A - Unclassified organism; cytoplasm; uncharacterized protein 215862 4989670 An18g01100 Aspergillus niger uncharacterized protein XP_001398574.3 214604 R 5061 CDS An18g01110 4989671 216620..216880 VIII 1 NT_166533.1 hypothetical protein 216880 4989671 An18g01110 Aspergillus niger hypothetical protein XP_001398575.1 216620 D 5061 CDS An18g01120 4989672 complement(join(217063..217109,217166..217667,217724..218600,218659..218688,218739..219121)) VIII 1 NT_166533.1 Catalytic activity: versicolorin B synthase from A. parasiticus catalyses the side chain cyclization of racemic versiconal hemiacetal to the bisfuran ring system of(-)-versicolorin B.; Pathway: versicolorin B synthase from A. parasiticus is involved in the aflatoxin biosynthetic pathway.; Remark: a splice site was detected upstream of the START codon.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Remark: the genes encoding the aflatoxin biosynthetic enzymes in A. parasiticus are clustered.; Remark: versicolorin B synthase from A. parasiticus possesses an amino-terminal sequence homologous to the ADP-binding region of other flavoenzymes, but does not require flavin or nicotinamide cofactors for its cyclase activity.; Similarity: the predicted A. niger protein shows strong similarity to versicolorin B synthase from A. parasiticus and other oxidoreductases.; Title: strong similarity to versicolorin B synthase vbs - Aspergillus parasiticus; See PMID 8662689; uncharacterized protein 219121 4989672 An18g01120 Aspergillus niger uncharacterized protein XP_001398576.1 217063 R 5061 CDS An18g01130 4989673 221050..222099 VIII 1 NT_166533.1 Remark: the patent does not provide further information about the function of the protein.; Similarity: the predicted A. niger protein shows similarity to the protein fragment (SEQ ID NO: 51484) of patent EP1033405-A2 from A. thaliana (AC# AAG41385) and to putative sterol desaturase family proteins.; Title: similarity to protein fragment SEQ ID NO:51484 from patent EP1033405-A2 - Arabidopsis thaliana; uncharacterized protein 222099 4989673 An18g01130 Aspergillus niger uncharacterized protein XP_001398577.1 221050 D 5061 CDS An18g01140 4989674 222449..223480 VIII 1 NT_166533.1 Title: similarity to ketopantoate reductase -Salmonella typhimurium; cytoplasm; See PMID 7519593; See PMID 9488683; uncharacterized protein 223480 4989674 An18g01140 Aspergillus niger uncharacterized protein XP_001398578.1 222449 D 5061 CDS An18g01150 4989675 join(224372..224796,224870..225988,226045..226315) VIII 1 NT_166533.1 Function: FLU1 of C. albicans facilitates resistance to fluconazole and cycloheximide in the fluconazole-hypersensitive S. cerevisiae strain YKKB-13 lacking the ABC (ATP-binding cassette) transporter gene PDR5.; Function: FLU1 of C. albicans facilitates resistance to mycophenolic acid in C. albicans.; Function: FLU1 of C. albicans is involved in the resistance to azol derivatives in C. albicans.; Function: MDR1 of C. albicans facilitates resistance to the anti-mitotic drug benomyl and to the dihydrofolate reductase inhibitor methotrexate.; Similarity: the predicted A. niger protein shows strong similarity to fluconazole resistance protein FLU1of C. albicans, which is a permease belonging to the major facilitator superfamily.; Title: strong similarity to fluconazole resistance protein FLU1 - Candida albicans; See PMID 11065353; uncharacterized protein 226315 4989675 An18g01150 Aspergillus niger uncharacterized protein XP_001398579.3 224372 D 5061 CDS An18g01170 4989677 join(227427..227496,227556..227669,227719..227988,228039..228884,228938..229020,229069..229638) VIII 1 NT_166533.1 Catalytic activity: the NAP protein of Z. mays catalyses the reaction NAD(+) + {ADP-D-ribosyl}(N)-acceptor <=> nicotinamide + {ADP-D-ribosyl}(N+1)-acceptor.; Function: the NAP protein of Z. mays is involved in programmed cell death or apoptosis.; Localization: the NAP protein of Z. mays is a nuclear enzyme.; Remark: the ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxyl group on a histone or the enzyme itself, and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.; Remark: the NAP polynucleotide sequences can be used for modulation of programmed cell death in eukaryotic cells. the method is used, specifically in plants, to induce, or protect against, programmed cell death,depending on the extent to which PARP activity is reduced. reducing expression of endogenous NAP class PARP only is also used to modulate programmed cell death, to increase growth rate and to produce plant cells that are more tolerant of stress (cold, chemical treatments, pathogens,pests, drought, heat, etc., or during transformation). particular applications are generation of plants that are resistant to fungi or nematodes; are male or female sterile; or have better seed-shatter properties. the methods are also used to improve growth of transformed plant cells (and derived calli or complete plants).; Similarity: the predicted A. niger protein shows strong similarity to the protein sequence poly(ADP-ribose) polymerase NAP protein of patent WO200004173-A1 from Z. mays (AC# AAY68834) and from many other eucaryotic organisms.; Title: strong similarity to poly(ADP-ribose) polymerase NAP protein from patent WO200004173-A1 - Zea mays; nucleus; See PMID 11246023; See PMID 11376691; See PMID 11385634; uncharacterized protein 229638 4989677 An18g01170 Aspergillus niger uncharacterized protein XP_001398580.1 227427 D 5061 CDS An18g01180 84593637 join(230523..232098,232162..232181) VIII 1 NT_166533.1 Function: penicillin V amidohydrolase (PVA) from F. oxysporum is used for the enzymatic hydrolysis of penicillin V (phenoxy-methylpenicillin) to 6-aminopenicillanic acid (6-APA). 6-APA is the active beta-lactam nucleus used in the manufacture of semi-synthetic penicillins.; Similarity: the predicted A. niger protein shows strong similarity to the protein sequence penicillin V amidohydrolase (PVA) of patent US5516679-A from F. oxysporum (AC# AAW00291).; Title: strong similarity to penicillin V amidohydrolase PVA from patent US5516679-A - Fusarium oxysporum; extracellular/secretion proteins; uncharacterized protein 232181 84593637 An18g01180 Aspergillus niger uncharacterized protein XP_059604974.1 230523 D 5061 CDS An18g01200 4989678 join(233494..233532,233625..233817,233877..234006,234063..234258,234346..234472,234527..234771,234843..235114,235182..235563) VIII 1 NT_166533.1 Function: ord1 of A. flavus converts O-methylsterigmatocystin to aflatoxin B1.; Pathway: ord1 of A. flavus catalyzes the last step of the aflatoxin biosynthetic pathway.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Similarity: the predicted A. niger protein shows strong similarity to O-methylsterigmatocystin (OMST)-oxidoreductase (ord1) from A. flavus, which belongs to the CYP64 family of cytochrome P450-type monooxygenases.; Title: strong similarity to O-methylsterigmatocystin oxidoreductase ord1 - Aspergillus flavus; See PMID 9143099; uncharacterized protein 235563 4989678 An18g01200 Aspergillus niger uncharacterized protein XP_059604975.1 233494 D 5061 CDS An18g01210 4989681 complement(join(235792..236003,236055..236217,236279..236583,236628..236953,237012..237364)) VIII 1 NT_166533.1 Function: SRPK2 from M. musculus phosphorylates SF2/ASF, a member of SR splicing factors.; Remark: overexpression of murine SRPK2 causes disassembly of cotransfected SF2/ASF and endogenous SC35. SRPK family members may regulate the disassembly of the SR proteins in a tissue-specific manner.; Similarity: the predicted A. niger protein shows similarity to SRPK2 from M. musculus and strong similarity to putative serine/threonine protein kinases from several eucaryotic organisms.; Title: similarity to SR-protein-specific kinase SRPK2 - Mus musculus; nucleus; See PMID 9446799; uncharacterized protein 237364 4989681 An18g01210 Aspergillus niger uncharacterized protein XP_059604976.1 235792 R 5061 CDS An18g01220 4989682 complement(join(237749..238375,238431..238978,239036..239144,239203..239406)) VIII 1 NT_166533.1 Function: in S. cerevisiae, mutants (dal5) that lack allantoate transport have been isolated. these strains also exhibit a 60% loss of allantoin transport capability.; Regulation: in S. cerevisiae Dal5 appears to be sensitive to nitrogen catabolite repression, feedback inhibition, and trans-inhibition.; Regulation: in S. cerevisiae allantoate uptake is constitutive.; Similarity: the predicted A. niger protein shows strong similarity to allantoate permease gene (DAL5) from S. cerevisiae, which belongs to the major facilitator superfamily.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 3275614; See PMID 3549700; uncharacterized protein 239406 4989682 An18g01220 Aspergillus niger uncharacterized protein XP_001398584.1 237749 R 5061 CDS An18g01230 4989683 join(240028..240289,240338..240405,240462..240653,240713..241012,241074..241355,241541..241802,241970..242088) VIII 1 NT_166533.1 Function: M. grisea Pth11 is a pathogenicity gene.; Function: M. grisea Pth11p likely is involved in host surface recognition.; Function: M. grisea pth11 mutants of strain 4091-5-8 are nonpathogenic due to a defect in appressorium differentiation.; Localization: in M. grisea, a Pth11-green fluorescent protein fusion localised to the cell membrane and vacuoles.; Similarity: similarity of the predicted A. niger protein and M. grisea Pth11 is limited to the N-terminal half of the protein sequences.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; plasma membrane; See PMID 10521529; uncharacterized protein 242088 4989683 An18g01230 Aspergillus niger uncharacterized protein XP_059604977.1 240028 D 5061 CDS An18g01240 4989684 join(242714..243085,243165..243450,243523..243822,243881..243956,244018..244204) VIII 1 NT_166533.1 Catalytic activity: NahW of P. stutzeri catalyzes the conversion salicylate + NADH + O(2) <=> catechol + NAD(+) + H(2)O + CO(2).; Pathway: NahW of P. stutzeri is involved in the metabolization of naphtalene and salicylates (lower naphtalene degradation pathway).; Similarity: the predicted A. niger protein shows similarity to salicylate hydroxylase (nahW) of P. stutzeri,which belongs to the NADH-dependent monooxygenase superfamily.; Title: similarity to salicylate hydroxylase nahW -Pseudomonas stutzeri; See PMID 10197990; uncharacterized protein 244204 4989684 An18g01240 Aspergillus niger uncharacterized protein XP_001398586.3 242714 D 5061 CDS An18g01250 4989685 complement(join(244437..244683,244764..244813)) VIII 1 NT_166533.1 Title: similarity to hypothetical protein encoded by An16g00840 - Aspergillus niger; uncharacterized protein 244813 4989685 An18g01250 Aspergillus niger uncharacterized protein XP_001398587.1 244437 R 5061 CDS An18g01270 84593638 join(245565..245599,245742..246069) VIII 1 NT_166533.1 hypothetical protein 246069 84593638 An18g01270 Aspergillus niger hypothetical protein XP_059604978.1 245565 D 5061 CDS An18g01280 84593639 complement(join(248079..248398,248591..248716,248753..248872,249116..249164)) VIII 1 NT_166533.1 hypothetical protein 249164 84593639 An18g01280 Aspergillus niger hypothetical protein XP_059604979.1 248079 R 5061 CDS An18g01290 4989689 join(249699..250298,250367..251032) VIII 1 NT_166533.1 Title: strong similarity to hypothetical protein encoded by An13g01340 - Aspergillus niger; uncharacterized protein 251032 4989689 An18g01290 Aspergillus niger uncharacterized protein XP_001398590.1 249699 D 5061 CDS An18g01300 4989690 251875..252684 VIII 1 NT_166533.1 Remark: paiB from B. subtilis seems to be essential.; Similarity: the predicted A. niger protein shows weak similarity to transcription regulator 2 of the pai operon of B. subtilis and conserved hypothetical proteins from several procaryotic organisms.; Title: similarity to transcription regulator paiB -Bacillus subtilis; See PMID 2108124; uncharacterized protein 252684 4989690 An18g01300 Aspergillus niger uncharacterized protein XP_001398591.1 251875 D 5061 CDS An18g01320 4989692 join(255507..255677,255741..256050,256111..257000) VIII 1 NT_166533.1 Function: BAR1 of S. cerevisiae selectively cleaves the 6-Leu-|-Lys-7 bond in the pheromone alpha-mating factor. BAR1 activity is abolished by in vitro mutation of an aspartic acid predicted to be in the active site.; Induction: secretion of BAR1 of S. cerevisiae is stimulated to as much as five times the basal level by exposure of cells to alpha-factor.; Localization: BAR1 of S. cerevisiae is secreted into the periplasmic space of MATa cells.; Remark: BAR1 of S. cerevisiae is already active in early compartments of the secretory pathway. Bar1 protease tolerates large N-terminal extensions of its substrate and does not require Golgi-specific modifications such as outer-chain glycosylation for activity.; Remark: the protein sequence of barrier protease BAR1 of S. cerevisiae is covered by patent WO9118988-A (AC# AAR20109). the patented barrier protease is useful in industrial processes where leucine-lysine or leucine-arginine cleavage is required at low pH or high temperature. barrier protease may also be used in the production and isolation of proteins made by genetic engineering methods, e. g. to cleave fusion proteins at Leu-Arg bonds.; Similarity: the predicted A. niger protein shows strong similarity to extracellular protease precursor BAR1 of S. cerevisiae which belongs to the subfamily A1 of aspartic-type peptidases.; Title: strong similarity to extracellular protease precursor Bar1 - Saccharomyces cerevisiae; extracellular/secretion proteins; See PMID 3124102; See PMID 6345506; See PMID 6397123; See PMID 9249020; uncharacterized protein 257000 4989692 An18g01320 Aspergillus niger uncharacterized protein XP_001398592.1 255507 D 5061 CDS An18g01330 4989693 join(257847..258364,258447..258773,258864..259086,259248..259373) VIII 1 NT_166533.1 hypothetical protein 259373 4989693 An18g01330 Aspergillus niger hypothetical protein XP_001398593.3 257847 D 5061 CDS An18g01340 4989694 join(259672..259834,259884..260037,260103..261444) VIII 1 NT_166533.1 Remark: the patent does not provide further information about the function of the protein, except for a claim of phytase activity.; Similarity: the predicted A. niger protein shows strong similarity to protein sequence 11 from patent EP0684313-A/11 and several putative phytases.; Title: strong similarity to sequence 11 from patent EP0684313-A - Unclassified organism; uncharacterized protein 261444 4989694 An18g01340 Aspergillus niger uncharacterized protein XP_001398594.1 259672 D 5061 CDS An18g01350 4989695 complement(join(261632..261859,261908..262085,262143..262699,262757..262816,262873..262885,262942..263152,263204..263344,263397..263463)) VIII 1 NT_166533.1 Remark: HA protein regulates homeostasis and adaptation. the C. glutamicum HA genes (I) can be used in vectors for expression in host cells and production of fine chemicals, such as, an organic acid, proteinogenic or nonproteinogenic amino acid (preferred), purine or pyrimidine base, nucleoside, nucleotide, lipid, saturated or unsaturated fatty acid, diol, carbohydrate, aromatic compound, vitamin, cofactor, polyketide or enzyme. the amino acids produced can be lysine, glutamine, glutamate,alanine, aspartate, glycine, serine, threonine, methionine,cysteine, valine, leucine, isoleucine, arginine, proline,histidine, tyrosine, phenylalanine, or tryptophan. the fine chemical production can be modulated. the presence of (I) or HA proteins encoded by then are used for diagnosing the presence or activity of Corynebacterium diphtheriae. (I) can be used to map the C. glutamicum genome or can be used as markers for genetically engineered Corynebacterium or Brevibacterium. the HA proteins encoded by the (I) are used to maintain homeostasis in C. glutamicum or help the microorganism to adapt to different environmental conditions.; Similarity: the predicted A. niger protein shows strong similarity to HA protein sequence SEQ ID NO:420 from patent WO200100842-A2 (AC# AAB79232), which is a monooxygenase by similarity.; Title: strong similarity to HA protein sequence SEQ ID NO:420 from patent WO200100842-A2 - Corynebacterium glutamicum; uncharacterized protein 263463 4989695 An18g01350 Aspergillus niger uncharacterized protein XP_001398595.1 261632 R 5061 CDS An18g01360 4989696 join(264246..264351,264384..264459,264504..264561,264609..264795,264845..264944,264987..265070,265117..265303,265348..265398,265446..265616,265663..265981,266030..266526,266589..266798) VIII 1 NT_166533.1 Function: S. cerevisiae DUR3 is a urea symporter mediating urea import.; Induction: high-level expression of S. cerevisiae DUR3 is inducer dependent, requiring functional DAL81 and DAL82 genes.; Regulation: expression of S. cerevisiae DUR3 is regulated in a manner similar to that of other genes in the allantoin pathway.; Repression: DUR3 expression is highly sensitive to nitrogen catabolite repression and also has a partial requirement for the GLN3 product.; Repression: maintenance of S. cerevisiae DUR3 mRNA at uninduced, nonrepressed basal levels requires the negatively acting DAL80 gene product.; Similarity: S. cerevisiae DUR3 belongs to the major facilitator family.; Title: strong similarity to urea transport protein Dur3 - Saccharomyces cerevisiae; plasma membrane; See PMID 8335627; uncharacterized protein 266798 4989696 An18g01360 Aspergillus niger uncharacterized protein XP_059604980.1 264246 D 5061 CDS An18g01370 84593640 join(267063..267162,267428..267601,267737..267829,268182..268243,268338..268446,268508..268662) VIII 1 NT_166533.1 hypothetical protein 268662 84593640 An18g01370 Aspergillus niger hypothetical protein XP_059604981.1 267063 D 5061 CDS An18g01380 4989698 complement(join(268740..268784,268878..268966,269107..269753,269830..269913,269978..270171,270248..270669,270723..270787,270961..271192,271261..271608,271676..271838,271888..272185,272242..272735,272865..272979,273144..273701,273801..273918,274018..274219,274289..274507)) VIII 1 NT_166533.1 Function: YCF1 from S. cerevisiae is required for cadmium resistance. S. cerevisiae cells harboring a deletion of the YCF1 gene are hypersensitive to cadmium compared with wild type cells.; Remark: mutagenesis experiments demonstrate that conserved amino acid residues, functionally critical in the human cystic fibrosis transmembrane conductance regulator (hCFTR), play a vital role in YCF1-mediated cadmium resistance.; Remark: substitution of a serine to alanine residue in a potential protein kinase A phosphorylation site in a central region of YCF1, which displays sequence similarity to the central regulatory domain of hCFTR, also rendered YCF1 nonfunctional.; Remark: the YCF1 gene of S. cerevisiae is an MgATP-energized, uncoupler-insensitive vacuolar membrane glutathione S-conjugate transporter.; Similarity: the predicted A. niger protein shows strong similarity to cadmium factor (YCF1) from S. cerevisiae, which belongs to the ATP binding cassette (ABC) protein superfamily of membrane transporters.; Title: strong similarity to cadmium resistance protein Ycf1 - Saccharomyces cerevisiae [putative sequencing error]; putative sequencing error; See PMID 7521334; See PMID 7798263; See PMID 8626454; See PMID 8990158; uncharacterized protein 274507 4989698 An18g01380 Aspergillus niger uncharacterized protein XP_059604982.1 268740 R 5061 CDS An18g01390 4989699 complement(275128..276732) VIII 1 NT_166533.1 Function: the CUP1 gene, and its copper-dependent transcriptional activator ACE1 play a key role in mediating copper resistance in S. cerevisiae.; Similarity: the predicted A. niger protein shows similarity to the copper homeostasis protein CUP9 from S. cerevisiae. the predicted A. niger protein shows strong similarity to the homeobox domain of many homeotic proteins.; Title: similarity to copper homeostasis protein Cup9 - Saccharomyces cerevisiae; nucleus; See PMID 7969120; uncharacterized protein 276732 4989699 An18g01390 Aspergillus niger uncharacterized protein XP_001398599.1 275128 R 5061 CDS An18g01400 4989700 join(277215..277585,277632..277886,277944..278382,278440..278607) VIII 1 NT_166533.1 Function: the MCT3 transporter from Rattus norvegicus is a proton-linked monocarboxylate transporter. it catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate,branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate,beta-hydroxybutyrate and acetate.; Similarity: the predicted A. niger protein shows strong similarity to the monocarboxylate transporter 3 (MCT3) of R. norvegicus, which belongs to the major facilitator superfamily.; Title: strong similarity to monocarboxylate transporter 3 MCT3 - Rattus norvegicus; See PMID 9632638; See PMID 9841555; uncharacterized protein 278607 4989700 An18g01400 Aspergillus niger uncharacterized protein XP_001398600.3 277215 D 5061 CDS An18g01410 4989701 join(279369..279447,279526..280235,280293..280859) VIII 1 NT_166533.1 Title: strong similarity to hypothetical protein B2J23.120 - Neurospora crassa; uncharacterized protein 280859 4989701 An18g01410 Aspergillus niger uncharacterized protein XP_001398601.1 279369 D 5061 CDS An18g01420 4989702 complement(join(280945..282167,282232..282625)) VIII 1 NT_166533.1 hypothetical protein 282625 4989702 An18g01420 Aspergillus niger hypothetical protein XP_059604983.1 280945 R 5061 CDS An18g01430 4989703 complement(join(284007..284785,284858..285140)) VIII 1 NT_166533.1 Catalytic activity: alcohol + NAD+ = aldehyde or ketone + NADH.; Pathway: alcohol dehydrogenase ADH-T from B. stearothermophilus is involved in glycolysis / gluconeogenesis; fatty acid metabolism; bile acid biosynthesis; tyrosine metabolism; glycerolipid metabolism.; Remark: the protein sequence of alcohol dehydrogenase ADH-T from B. stearothermophilus NCA1503 is covered by patent JP04218378-A (AC# AAR26874).; Similarity: the predicted A. niger protein shows strong similarity to thermostable alcohol dehydrogenase ADH-T from B. stearothermophilus NCA1503, which belongs to the zinc alcohol dehydrogenase (ADH) family.; Title: strong similarity to thermostable alcohol dehydrogenase adhT - Bacillus stearothermophilus; See PMID 1735726; See PMID 10971204; uncharacterized protein 285140 4989703 An18g01430 Aspergillus niger uncharacterized protein XP_059604984.1 284007 R 5061 CDS An18g01440 4989704 join(285519..285602,285847..285863,285903..286004,286036..286043,286265..286797,286849..288186) VIII 1 NT_166533.1 Similarity: the predicted A. niger protein shows local similarity to the hypothetical protein mll8086 from M. loti.; Title: strong similarity to hypothetical protein CAD70872.1 - Neurospora crassa; uncharacterized protein 288186 4989704 An18g01440 Aspergillus niger uncharacterized protein XP_059604985.1 285519 D 5061 CDS An18g01450 84593641 join(289875..290209,290291..290447) VIII 1 NT_166533.1 Function: ordA of A. parasiticus is involved in the aflatoxin biosynthesis and converts O-methylsterigmatocystin (OMST) to aflatoxins B1 or G1 and converts dihydro-O-methylsterigmatocystin (DHOMST) to aflatoxins B2 or G2.; Remark: aflatoxins comprise a group of polyketide-derived carcinogenic mycotoxins.; Remark: it is assumed that the ORF is N-terminally shorter and has another start codon 5' to the predicted one; the ORF is around 400 amino acids shorter than most of the homologues cytochrome p450 proteins.; Remark: ordA of A. parasiticus is also called cytochrome p450 64, cyp64 or omst oxidoreductase.; Similarity: the ORF shows similarity to several cytochrome P450 related proteins from different species.; Title: strong similarity to O-methylsterigmatocystin oxidoreductase ordA - Aspergillus parasiticus; See PMID 9532734; uncharacterized protein 290447 84593641 An18g01450 Aspergillus niger uncharacterized protein XP_059604986.1 289875 D 5061 CDS An18g01460 4989706 join(290923..290971,291024..291384,291439..291551,291610..291632,291689..291741,291795..291984) VIII 1 NT_166533.1 Catalytic activity: cyclohexanol dehydrogenases convert cyclohexanol + NAD(+) <=> cyclohexanone + NADH.; Function: chnA of A. sp. is an alcohol dehydrogenases proposed to catalyze the conversion of cyclohexanol to cyclohexanone (EC 1. 1. 1. 245).; Phenotype: cyclohexanol was detected as the major intermediate accumulated in the chnA mutant of A. sp.; Remark: chnA of A. sp. is encoded in the gene cluster for cyclohexanol oxidation.; Similarity: the ORF shows similarity to several dehydrogenases from different species and with various specificities.; Title: strong similarity to cyclohexanol dehydrogenase chnA - Acinetobacter sp.; See PMID 10940013; uncharacterized protein 291984 4989706 An18g01460 Aspergillus niger uncharacterized protein XP_001398606.1 290923 D 5061 CDS An18g01470 4989707 join(292470..292588,292664..292667,292733..292949,293021..293422,293485..293549,293804..293825,293888..293937,293999..294136,294168..294396,294510..294604,294779..294853) VIII 1 NT_166533.1 Remark: aflatoxins are polyketide-derived secondary metabolites.; Remark: moxY of A. parasiticus is expressed concurrently with genes involved in aflatoxin biosynthesis and it lies on one end of the cluster of this genes. Therefore moxY of A. parasiticus is presumably also involved in aflatoxin biosynthesis.; Similarity: the ORF shows similarity to monooxigenases from several species and with different functions.; Title: strong similarity to monooxygenase moxY -Aspergillus parasiticus; See PMID 10855719; uncharacterized protein 294853 4989707 An18g01470 Aspergillus niger uncharacterized protein XP_059604987.1 292470 D 5061 CDS An18g01480 4989708 295551..297104 VIII 1 NT_166533.1 Function: eln2 of C. cinereus encodes a novel type of microsomal cytochrome P450 enzyme, with is involved in mushroom morphogenesis.; Phenotype: a dominant mutation of the elongationless2 (eln2) gene of the mushroom C. cinereus affects pattern formation in the development of fruit body primordia, causing dumpy primordia which culminate in mature fruit bodies with short stipes.; Similarity: the ORF shows similarity to several cytochrome p450 related proteins from different species,which have different cellular functions.; Title: strong similarity to cytochrome p450 related protein eln2 - Coprinus cinereus; See PMID 10779399; uncharacterized protein 297104 4989708 An18g01480 Aspergillus niger uncharacterized protein XP_001398608.1 295551 D 5061 CDS An18g01490 4989709 complement(join(297209..297797,297854..298377)) VIII 1 NT_166533.1 Function: alr2 of S. cerevisiae is an uptake transporter for inorganic cations, e. g. magnesium, which presence seems to be important for resistance to the toxic effect of aluminum.; Remark: alr2 of S. cerevisiae is also called YFL050C.; Similarity: the predicted ORF is 395 amino acids shorter at the N-terminus and 57 amino acids shorter at its C-terminal end than alr2 of S. cerevisiae (nearly the same is true for alr1 of S. cerevisiae).; Title: strong similarity to ion transporter Alr2 -Saccharomyces cerevisiae; plasma membrane; See PMID 9430719; uncharacterized protein 298377 4989709 An18g01490 Aspergillus niger uncharacterized protein XP_001398609.1 297209 R 5061 CDS An18g01500 4989710 complement(join(299193..299378,299435..299660,299724..300088)) VIII 1 NT_166533.1 Title: strong similarity to hypothetical protein encoded by An15g02540 - Aspergillus niger; uncharacterized protein 300088 4989710 An18g01500 Aspergillus niger uncharacterized protein XP_001398610.1 299193 R 5061 CDS An18g01510 84593642 complement(join(301316..301426,301529..301665,301767..301878)) VIII 1 NT_166533.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure and short lenght; Title: questionable ORF; uncharacterized protein 301878 84593642 An18g01510 Aspergillus niger uncharacterized protein XP_059604988.1 301316 R 5061 CDS An18g01520 4989712 302820..303941 VIII 1 NT_166533.1 Function: due to the presence of a putative 'zinc cluster' motif and its low (16%) but significant similarity with the DNA-directed DNA polymerase of hepatitis B virus,it was assumed that qutH of A. nidulans is a DNA-binding protein, which is possibly involved in the regulation of genes essential for the utilisation of protocatechuic acid.; Function: due to the similarity of the ORF to oxidoreductases, it is here assumed that the ORF is encoding a protein with oxidoreductase activity.; Similarity: the ORF shows similarity to several oxidoreductases from different species.; Title: strong similarity to quinic-acid utilisation gene qutH - Aspergillus nidulans; See PMID 2976880; uncharacterized protein 303941 4989712 An18g01520 Aspergillus niger uncharacterized protein XP_001398612.1 302820 D 5061 CDS An18g01530 4989713 complement(join(304017..304500,304556..305063,305123..305159,305228..305431)) VIII 1 NT_166533.1 Function: pth11 of M. grisea is involved in host surface recognition for the initiation of appressorium formation, which is important in plant infection.; Phenotype: M. grisea pth11 mutants are nonpathogenic due to a defect in appressorium differentiation.; Remark: on the same contig another ORF shows similarity to pth11 of M. grisea, see 130cg.; Similarity: the ORF is 85 amino acids shorter at its N-terminus and 155 amino acids shorter at the C-terminal end than pth11 of M. grisea.; Title: strong similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529; See PMID 11113382; uncharacterized protein 305431 4989713 An18g01530 Aspergillus niger uncharacterized protein XP_059604989.1 304017 R 5061 CDS An18g01540 4989714 306130..307539 VIII 1 NT_166533.1 Function: TRI101 of F. sporotrichioides conferred significant increased tolerance to the mycotoxin DAS (trichothecene 4,15-diacetoxyscirpenol), which is harmful for vertebrates.; Function: TRI101 of F. sporotrichioides converts isotrichodermol to isotrichodermin and is required for the modification of T-2 toxin, which inhibits protein synthesis in eukaryotes.; Phenotype: TRI101 mutants of F. sporotrichioides were altered in their abilities to synthesize T-2 toxin and accumulated isotrichodermol and small amounts of 3,15-didecalonectrin and 3-decalonectrin, trichothecenes.; Title: strong similarity to trichothecene 3-O-acetyltransferase TRI101 - Fusarium sporotrichioides; See PMID 9762900; See PMID 10583973; See PMID 10960733; uncharacterized protein 307539 4989714 An18g01540 Aspergillus niger uncharacterized protein XP_059604990.1 306130 D 5061 CDS An18g01550 4989715 complement(join(307628..307704,307827..308776,308825..309076,309129..309376,309557..310789)) VIII 1 NT_166533.1 Title: similarity to hypothetical protein AAM43672.1 - Dictyostelium discoideum; uncharacterized protein 310789 4989715 An18g01550 Aspergillus niger uncharacterized protein XP_059604991.1 307628 R 5061 CDS An18g01560 84593643 join(311506..311617,311793..311882,311954..312076,312210..312328,312421..312498,312579..312670,312769..312874) VIII 1 NT_166533.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Title: questionable ORF; uncharacterized protein 312874 84593643 An18g01560 Aspergillus niger uncharacterized protein XP_059604992.1 311506 D 5061 CDS An18g01570 4989717 join(313051..313200,313248..313364,313412..313602,313652..313774,313820..313900,313965..314373,314510..314560) VIII 1 NT_166533.1 Function: pth11 of M. grisea pth11 is involved in host surface recognition for the initiation of appressorium formation, which is important in plant infection.; Phenotype: M. grisea pth11 mutants are nonpathogenic due to a defect in appressorium differentiation.; Remark: on the same contig another ORF shows strong similarity to pth11 of M. grisea, see 160wg.; Similarity: the ORF is 92 amino acids shorter at the N-terminal end and 165 amino acid its C-terminus than pth11 of M. grisea.; Title: similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529; See PMID 11113382; uncharacterized protein 314560 4989717 An18g01570 Aspergillus niger uncharacterized protein XP_001398617.3 313051 D 5061 CDS An18g01580 4989718 complement(join(315290..315939,316007..316019)) VIII 1 NT_166533.1 Catalytic activity: pca1 of P. purpureum converts H(2)CO(3) <=> CO(2) + H(2)O with the usage of zinc as cofactor.; Function: carbonic anhydrases catalyze the reversible hydration of carbon dioxide.; Remark: an alternate name for pca1 of P. purpureum is gtpca1.; Similarity: the ORF shows similarity to several carbonic anhydrases from different species and with various cellular functions.; Title: strong similarity to carbonic anhydrase pca1 - Porphyridium purpureum; See PMID 8910506; See PMID 11316870; uncharacterized protein 316019 4989718 An18g01580 Aspergillus niger uncharacterized protein XP_001398618.1 315290 R 5061 CDS An18g01590 4989719 complement(join(316726..316858,316921..318583,318644..318689,318757..318846)) VIII 1 NT_166533.1 Catalytic activity: cat2 of C. tropicalis catalyses acetyl-CoA + carnitine <=> CoA + O-acetylcarnitine.; Function: cat2 of C. tropicalis is specific for the acetylation of short chain fatty acids and may also be involved in the transport of acety-CoA into mitochondria.; Similarity: the ORF overlaps with A. niger EST EMBLEST:BE760390.; Title: strong similarity to carnitine O-acetyltransferase cat2 - Candida tropicalis; inner membrane; uncharacterized protein 318846 4989719 An18g01590 Aspergillus niger uncharacterized protein XP_001398619.1 316726 R 5061 CDS An18g01600 4989720 complement(join(319584..319763,319819..320120,320178..320508,320616..320810)) VIII 1 NT_166533.1 Function: srpk2 was first found to mediate the interaction and localization of pre-mRNA splicing factors by phosphorylating the SR (serine/arginine-rich) family of splicing factors and therefore probably controls the activity of splicing.; Phenotype: overexpression of srpk2 in M. musculus causes disassembly of cotransfected SF2/ASF and endogenous SC35.; Similarity: the ORF shows similarity to several protein kinases from different species and with various specificity.; Title: strong similarity to serine/arginine-rich protein-specific kinase srpk2 - Mus musculus; deleted EC_number 2.7.1.37; See PMID 9472028; uncharacterized protein 320810 4989720 An18g01600 Aspergillus niger uncharacterized protein XP_059604993.1 319584 R 5061 CDS An18g01610 4989721 complement(join(321664..322931,322982..323367,323434..323705)) VIII 1 NT_166533.1 Function: srb4 of S. cerevisiae is a component of the multi subunitcomplex, which binds to RNA polymerase II and is essential for efficient establishment of the transcription initiation apparatus.; Phenotype: the S. cerevisiae srb4 the null mutant is inviable and srb4 mutants display global defects in mRNA synthesis.; Remark: an alternate name for srb4 of S. cerevisiae is YER022w.; Title: strong similarity to RNA polymerase II suppressor protein Srb4 - Saccharomyces cerevisiae; nucleus; See PMID 8187178; uncharacterized protein 323705 4989721 An18g01610 Aspergillus niger uncharacterized protein XP_001398621.1 321664 R 5061 CDS An18g01620 4989722 complement(join(325257..326328,326379..326923)) VIII 1 NT_166533.1 Catalytic activity: linoleate isomerases catalyse the isomerisation of 9-cis,12-cis-octadecadienoate <=> 9-cis,11-trans-octadecadienoate.; Function: linoleate isomerase of patent WO9932604-A1 is used to produce conjugated linoleic/linolenic acid (CLA) from oils such as sunflower oil, safflower oil, corn oil, linseed oil, etc.; Similarity: the ORF shows strong similarity to myosin-crossreactive antigen, which could induce autoimmune reactions in vertebrates.; Title: strong similarity to linoleate isomerase from patent WO9932604-A1 - Lactobacillus reuteri; uncharacterized protein 326923 4989722 An18g01620 Aspergillus niger uncharacterized protein XP_001398622.1 325257 R 5061 CDS An18g01630 4989723 join(327676..327813,327874..329017,329071..329222) VIII 1 NT_166533.1 Catalytic activity: HDNO of A. oxidans catalyses (D)-6-hydroxynicotine + H(2)O + O(2) = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H(2)O(2).; Induction: HDNO of A. oxidans requires FAD in the enzymatic assay for maximal enzyme activity.; Similarity: the ORF shows similarity to several FAD-dependent oxygenases from different species and with various specificity.; Title: strong similarity to 6-hydroxy-D-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 3905431; uncharacterized protein 329222 4989723 An18g01630 Aspergillus niger uncharacterized protein XP_001398623.1 327676 D 5061 CDS An18g01640 4989724 join(330077..330133,330190..330596,330642..330917,330975..331439,331489..331598,331650..332329) VIII 1 NT_166533.1 Function: TSase of G. frondosa catalyzes the trehalose synthesis from alpha-D-glucose 1-phosphate and D-glucose.; Similarity: the ORF shows similarity to a clock-controlled gene (ccgs) of N. crassa with unknown function.; Title: strong similarity to trehalose synthase TSase - Grifola frondosa; See PMID 9763690; See PMID 9797287; uncharacterized protein 332329 4989724 An18g01640 Aspergillus niger uncharacterized protein XP_001398624.1 330077 D 5061 CDS An18g01660 84593644 join(333565..333580,333788..334146,334221..334247) VIII 1 NT_166533.1 Remark: the ORF is questionable due to its suboptimal intron-exon structure.; Similarity: the ORF overlaps with the 5' region of the A. niger pfkA gene.; Title: questionable ORF; uncharacterized protein 334247 84593644 An18g01660 Aspergillus niger uncharacterized protein XP_059604994.1 333565 D 5061 CDS An18g01670 4989727 join(334275..335015,335072..335533,335581..336729) VIII 1 NT_166533.1 Catalytic activity: pfkA of A. niger is catalysing ATP + D-fructose 6-phosphate <=> ADP + D-fructose 1,6-bisphosphate.; Function: pfkA of A. niger is active in a key control step of glycolysis.; Gene-ID: pfkA; Similarity: the ORF overlaps with the sequence of entry EMBL:ANPFKA (A. niger pfkA gene); cytoplasm; See PMID 6223622; See PMID 8020755; See PMID 9101728; See PMID 2936730; 6-phosphofructokinase pfkA-Aspergillus niger 336729 pfkA 4989727 pfkA Aspergillus niger 6-phosphofructokinase pfkA-Aspergillus niger XP_001398626.1 334275 D 5061 CDS An18g01680 4989728 complement(join(337054..337073,337153..338152)) VIII 1 NT_166533.1 Catalytic activity: NADH dehydrogenases catalyse NADH + acceptor <=> NAD(+) + reduced acceptor.; Function: ndh of P. fluorescens is involved in colonization of this bacterium.; Phenotype: in an oxygen-poor medium mutant PCL1201 of P. fluorescens, which carries a mutation in the ndh gene showed a decreased growth rate.; Remark: the sequence of the database entry EMBL:ANPFKA (A. niger pfkA gene) overlaps with the ORF due a probably wrong nummer of 4658 bp for the coding sequence of the A. niger protein, which is encoded 3'.; Similarity: the ORF is 112 amino acids shorter at its C-terminal end than ndh of P. fluorescens.; Title: similarity to NADH dehydrogenase II ndh -Pseudomonas fluorescens; localisation:mitochondrion; See PMID 9675892; uncharacterized protein 338152 4989728 An18g01680 Aspergillus niger uncharacterized protein XP_059604995.1 337054 R 5061 CDS An18g01690 4989729 complement(join(338433..338513,338565..338704,338764..339558,339625..339772,339823..339837,339889..339962,340015..340039)) VIII 1 NT_166533.1 Title: strong similarity to hypothetical protein YOR155c - Saccharomyces cerevisiae; uncharacterized protein 340039 4989729 An18g01690 Aspergillus niger uncharacterized protein XP_059604996.1 338433 R 5061 CDS An18g01700 4989730 complement(join(340471..341532,341582..341710,341759..341954,342008..342282)) VIII 1 NT_166533.1 Function: qutD of E. nidulans is involved in quinic acid transport with similarity to the maltose transport protein MAL61.; Phenotype: mutations in the qutD gene of A. nidulans cause the loss of ability to grow upon quinic acid as sole carbon source in media at normal pH 6. 5 and failure to induce three enzyme activities specifically required for metabolism to protochatechuic acid.; Similarity: the ORF overlaps with A. niger EST EMBLEST:BE759752.; Title: strong similarity to quinate transport protein qutD - Aspergillus nidulans; See PMID 2976880; See PMID 2835177; uncharacterized protein 342282 4989730 An18g01700 Aspergillus niger uncharacterized protein XP_001398629.1 340471 R 5061 CDS An18g01710 84593645 join(342605..342828,342857..343169) VIII 1 NT_166533.1 hypothetical protein 343169 84593645 An18g01710 Aspergillus niger hypothetical protein XP_059604997.1 342605 D 5061 CDS An18g01720 4989732 join(343619..343960,344011..344376,344426..345382,345440..345493) VIII 1 NT_166533.1 Function: CaMDR1 of C. albicans the confers insensitivity to the anti-mitotic drug, benomyl, and to the dihydrofolate reductase inhibitor, methotrexate.; Remark: seven different mutant alleles of CaMDR1 from C. albicans showed distinct drug resistance profiles.; Similarity: the ORF shows similarity to several major facilitator proteins from different species.; Title: strong similarity to benomyl/methotrexate resistance protein MDR1 - Candida albicans; plasma membrane; See PMID 8031026; See PMID 2062311; uncharacterized protein 345493 4989732 An18g01720 Aspergillus niger uncharacterized protein XP_001398631.1 343619 D 5061 CDS An18g01730 4989733 complement(346330..>347310) VIII 1 NT_166533.1 Remark: the ORF is N-terminally truncated due to contig border.; Title: strong similarity to hypothetical protein encoded by An12g00980 - Aspergillus niger [truncated ORF]; uncharacterized protein 347310 4989733 An18g01730 Aspergillus niger uncharacterized protein XP_001398632.3 346330 R 5061 CDS An18g01740 4989734 complement(join(349299..349678,349740..350179,350247..350413)) VIII 1 NT_166533.1 Catalytic activity: nitrilases convert a nitrile + H(2)O <=> a carboxylate + NH(3).; Function: nitrile-hydrating enzymes produced by bacteria and fungi catalyse the conversion of a large number of chemically diverse nitriles, including many economically important compounds used industrially for chemical synthesis of amides and acids.; Similarity: the ORF shows similarity to several nitrilases from different species.; Title: strong similarity to aliphatic nitrilase -Rhodococcus rhodochrous; See PMID 3073055; uncharacterized protein 350413 4989734 An18g01740 Aspergillus niger uncharacterized protein XP_001398633.1 349299 R 5061 CDS An18g01750 4989735 join(351223..351298,351350..351628,351693..352333) VIII 1 NT_166533.1 Similarity: the ORF shows similarity to several short-chain dehydrogenases from different species, it is therefore not possible to predict its specific function.; Title: similarity to 3-dehydroecdysone 3alpha-reductase - Spodoptera littoralis; See PMID 10861234; uncharacterized protein 352333 4989735 An18g01750 Aspergillus niger uncharacterized protein XP_001398634.1 351223 D 5061 CDS An18g01760 4989736 complement(join(352592..353158,353213..353771,353841..354143,354241..354314)) VIII 1 NT_166533.1 Function: mst1 of A. muscaria is a H(+)/monosaccharide cotransporter necessary for the supply of plant-derived carbohydrates to the fungus.; Induction: in mycorrhizas as well as in hyphae grown at monosaccharide concentrations above 5 mM, the amount of mst1 transcript in A. muscaria increased fourfold.; Similarity: the ORF shows similarity to several hexose transport proteins from different species.; Title: strong similarity to monosaccharide transporter AmMst-1 - Amanita muscaria; plasma membrane; uncharacterized protein 354314 4989736 An18g01760 Aspergillus niger uncharacterized protein XP_001398635.1 352592 R 5061 CDS An18g01770 4989737 complement(join(354797..354844,354964..355180,355384..355903,355976..356472,356536..356746,356837..357018,357105..357241,357477..357584)) VIII 1 NT_166533.1 Similarity: the ORF contains a zinc-finger domain,which shows similarity to other zinc-finger domains from various proteins.; Title: similarity to hypothetical zinc-finger protein SPBC15D4.02 - Schizosaccharomyces pombe; uncharacterized protein 357584 4989737 An18g01770 Aspergillus niger uncharacterized protein XP_001398636.3 354797 R 5061 CDS An18g01780 4989738 complement(<358497..359868) VIII 1 NT_166533.1 Catalytic activity: the dihydropteridine reductase activity of hmp from E. coli converts NAD(P)H + 6,7-dihydroteridine = NAD(P)(+) + 5,6,7,8-tetrahydropteridine.; Function: hmp of E. coli possesses dihydropteridine reductase activity and has nitric oxide dioxygenase activity.; Function: hmp of E. coli seems to reduce the complexed Fe3+ iron of siderophores to Fe2+, thus releasing it from the chelator.; Induction: hmp of E. coli needs FAD and protoheme IX as cofactors.; Remark: a putative frameshift due to a possible sequencing error was corrected at position 53851 of the DNA sequence (1 bp to much).; Remark: hmp of E. coli is also called HMPA, FSRB or B2552.; Remark: the combination of FNR-like and haemoglobin-like regions in HMP represents a novel pairing of functionally and structurally distinct domains.; Title: strong similarity to flavohemoglobin hmp -Escherichia coli [putative frameshift]; cytoplasm; putative frameshift; See PMID 1601132; uncharacterized protein 359868 4989738 An18g01780 Aspergillus niger uncharacterized protein XP_059604998.1 358497 R 5061 CDS An18g01790 4989739 complement(join(360653..360755,360810..360982)) VIII 1 NT_166533.1 Remark: the ORF is questionable due to its short lenght of only 91 amino acids.; Title: questionable ORF; uncharacterized protein 360982 4989739 An18g01790 Aspergillus niger uncharacterized protein XP_001398638.1 360653 R 5061 CDS An18g01800 84593646 complement(join(362275..362970,363036..363115,363166..363229)) VIII 1 NT_166533.1 Function: c-tak1 (for Cdc twenty-five C associated protein kinase) phosphorylates Cdc25C in vitro and by this regulates the activity of the dual-specificity protein kinase that controls entry into mitosis by dephosphorylating Cdc2.; Similarity: the ORF shows similarity to several serine/threonine-specific protein kinase with different specificities and various cellular functions.; Title: similarity to cdc25C associated protein kinase c-tak1 - Homo sapiens; uncharacterized protein 363229 84593646 An18g01800 Aspergillus niger uncharacterized protein XP_059604999.1 362275 R 5061 CDS An18g01810 84593647 join(363524..363634,363734..364213) VIII 1 NT_166533.1 hypothetical protein 364213 84593647 An18g01810 Aspergillus niger hypothetical protein XP_059605000.1 363524 D 5061 CDS An18g01820 84593648 complement(join(364315..364533,364639..364698,364802..364942)) VIII 1 NT_166533.1 hypothetical protein 364942 84593648 An18g01820 Aspergillus niger hypothetical protein XP_059605001.1 364315 R 5061 CDS An18g01830 4989743 join(365045..365234,365288..365533,365580..366040,366074..366739) VIII 1 NT_166533.1 Induction: in S. cerevisiae the relatively high basal level of DAL5 expression did not increase further upon addition of allantoin pathway intermediates.; Phenotype: the null mutant of S. cerevisiae DAL5 is viable, but unable to transport allontoate or ureidosuccinate.; Remark: DAL5 of S. cerevisiae is also called J223,YJR152w or UREp1.; Repression: in S. cerevisiae steady-state DAL5 mRNA levels dropped precipitously when a repressive nitrogen source was provided.; Similarity: DAL5 from S. cerevisiae is a member of the major facilitator family.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; uncharacterized protein 366739 4989743 An18g01830 Aspergillus niger uncharacterized protein XP_059605002.1 365045 D 5061 CDS An18g01840 4989744 join(368197..369054,369130..369293,369361..369659,369708..369931,369989..370531) VIII 1 NT_166533.1 Function: fcr1 of C. albicans behaves as a negative regulator of drug resistance.; Phenotype: overexpression of fcr1 in the pdr1 pdr3 mutant of S. cerevisiae, which are hypersensitive to fluconazole (FCZ) resulted in increased resistance of the cells to FCZ and cycloheximide and in increased expression of PDR5, a gene coding for a drug efflux transporter of the ATP-binding cassette superfamily.; Similarity: the ORF shows similarity to several zinc finger transcription factors from different species with various function.; Title: similarity to zinc-cluster transcription factor fcr1 - Candida albicans; nucleus; See PMID 9864335; uncharacterized protein 370531 4989744 An18g01840 Aspergillus niger uncharacterized protein XP_059605003.1 368197 D 5061 CDS An18g01850 84593649 complement(join(371921..372221,372371..372468)) VIII 1 NT_166533.1 Remark: prostaglandin-endoperoxide synthases are 470 amino acids longer than the predicted ORF.; Similarity: the ORF shows similarity to several prostaglandin-endoperoxide synthases (cyclooxygenase-2) from different species, but the homologues region does not contain the characteristic active site distral histidine and the cyclooxigenase catalytic domain.; Title: weak similarity to prostaglandin-endoperoxide synthase 2 - Rattus norvegicus; uncharacterized protein 372468 84593649 An18g01850 Aspergillus niger uncharacterized protein XP_059605004.1 371921 R 5061 CDS An18g01860 4989746 join(372481..373417,373461..373500,373531..374244,374292..375320,375368..375638,375686..375800,375851..376062) VIII 1 NT_166533.1 Function: nik-1 of N. crassa is a two-component protein, an autophosphorylating histidine kinase and a response regulator, which is probably involved in nutrient deprivation response.; Function: nik-1 of N. crassa is also involved in hyphal development.; Phenotype: deletion of the nik-1+ gene in N. crassa results in an organism that displays aberrant hyphal structure, which is enhanced under conditions of high osmostress.; Remark: no transmembrane domains were predicted,which are usually found in a two-component sensor/response regulator.; Remark: the os-1+ protein is identical to the N. crassa nik-1.; Title: strong similarity to two-component sensor/response regulator nik-1 - Neurospora crassa; plasma membrane; See PMID 8622950; See PMID 10510225; uncharacterized protein 376062 4989746 An18g01860 Aspergillus niger uncharacterized protein XP_059605005.1 372481 D 5061 CDS An18g01870 84593650 complement(join(376343..376479,376569..376637,377009..377124,377204..377572,377683..377708)) VIII 1 NT_166533.1 hypothetical protein 377708 84593650 An18g01870 Aspergillus niger hypothetical protein XP_059605006.1 376343 R 5061 CDS An18g01880 84593651 complement(join(378187..378209,378310..378628,378739..379025,379198..379290,379577..379727,379789..380022)) VIII 1 NT_166533.1 Similarity: the region from amino acid 300 to 360 of the ORF contains a GTP-binding domain (WD, G-beta repeat),which shows similarity to several proteins with different functions, that all express this motive.; Title: weak similarity to beta transducin-like protein het-e1 - Podospora anserina; uncharacterized protein 380022 84593651 An18g01880 Aspergillus niger uncharacterized protein XP_059605007.1 378187 R 5061 CDS An18g01890 4989749 complement(join(381533..382060,382111..383616,383673..383817,383870..384972)) VIII 1 NT_166533.1 Similarity: the ORF shows similarity to several glutamic acid-rich proteins and some calcium-binding proteins with unspecified function.; Title: similarity to hypothetical protein K07E12.1 -Caenorhabditis elegans; uncharacterized protein 384972 4989749 An18g01890 Aspergillus niger uncharacterized protein XP_001398648.1 381533 R 5061 CDS An18g01900 84593652 join(386036..386228,386319..386396,386562..386752) VIII 1 NT_166533.1 hypothetical protein 386752 84593652 An18g01900 Aspergillus niger hypothetical protein XP_059605008.1 386036 D 5061 CDS An18g01910 84593653 join(387316..387607,387693..388577,388762..389522) VIII 1 NT_166533.1 Similarity: the C-terminal part of the ORF, starting with amino acid 440, shows similarity to a region of the beta transducin-like protein of P. anserina, which contains the GTP-binding domain.; Similarity: the N-terminal part of the ORF, spanning the region from amino acid 14 to 90 is similar to the sequence of gene CG12065 from D. melanogaster and the hypothetical protein H14E04. 2a of C. elegans.; Title: weak similarity to hypothetical protein CAD21096.1 - Neurospora crassa; uncharacterized protein 389522 84593653 An18g01910 Aspergillus niger uncharacterized protein XP_059605009.1 387316 D 5061 CDS An18g01920 84593654 389727..391130 VIII 1 NT_166533.1 Function: the ankyrin repeat is one of the most common protein sequence motifs found in a variety proteins with different activities.; Similarity: the predicted ORF shows similarity to ankyrin isoforms from several species, which is due to the presence of ankyrin-repeat homology domain.; Similarity: the similarity to ankryrin repeat domains is located in the C-terminal part of the predicted ORF, starting around amino acid 180.; Title: similarity to ankyrin AAC37208.1 - Drosophila melanogaster; See PMID 7937942; uncharacterized protein 391130 84593654 An18g01920 Aspergillus niger uncharacterized protein XP_059605010.1 389727 D 5061 CDS An18g01930 4989753 complement(join(392494..392506,392563..393095)) VIII 1 NT_166533.1 Title: similarity to hypothetical protein encoded by An11g06690 - Aspergillus niger; uncharacterized protein 393095 4989753 An18g01930 Aspergillus niger uncharacterized protein XP_001398652.1 392494 R 5061 CDS An18g01940 84593655 join(393200..393343,393387..393440,393509..393600,394002..394068) VIII 1 NT_166533.1 hypothetical protein 394068 84593655 An18g01940 Aspergillus niger hypothetical protein XP_059605011.1 393200 D 5061 CDS An18g01950 4989755 join(395140..395964,396022..396726) VIII 1 NT_166533.1 Title: strong similarity to hypothetical protein BAC67939.1 - Streptomyces avermitilis; uncharacterized protein 396726 4989755 An18g01950 Aspergillus niger uncharacterized protein XP_001398654.1 395140 D 5061 CDS An18g01960 4989756 complement(join(397162..397419,397478..397789,397842..398520,398570..398825,398875..399093,399144..399693)) VIII 1 NT_166533.1 Catalytic activity: plsB of E. coli catalyses acyl-CoA + glycerol 3-phosphate = CoA + 1-acyl-glycerol 3-phosphate.; Function: plsB of E. coli catalyzes the first step in de novo phospholipid biosynthesis, the condensation of glycerol-3-phosphate and fatty acid thioesters to yield lysophosphatidic acid; it may also function in the regulation of membrane biogenesis.; Phenotype: E. coli plsB mutants that were conditionally defective in sn-glycerol-3-phosphate acyltransferase activity generated more fatty acids in which glycerol-3-phosphate was not acylated but instead preferentially phosphatidylglycerol.; Remark: plsB of E. coli is also called GPAT, Z5640 or ECS502.; Similarity: the ORF shows similarity to several glycerol-3-phosphate O-acyltransferases from different species.; Title: strong similarity to sn-glycerol-3-phosphate acyltransferase plsB - Escherichia coli; See PMID 3542964; See PMID 6251087; See PMID 6985897; uncharacterized protein 399693 4989756 An18g01960 Aspergillus niger uncharacterized protein XP_001398655.3 397162 R 5061 CDS An18g01970 4989757 400459..401496 VIII 1 NT_166533.1 Catalytic activity: panC of C. glutamicum converts ATP + (R)-pantoate + beta-alanine <=> AMP + diphosphate + (R)-pantothenate.; Pathway: panC of C. glutamicum is involved in pantothenate and coenzyme A biosynthesis.; Similarity: the ORF shows similarity to several pantoate--beta-alanine ligases from different species,especially bacteria.; Title: strong similarity to pantoate--beta-alanine ligase panC - Corynebacterium glutamicum; uncharacterized protein 401496 4989757 An18g01970 Aspergillus niger uncharacterized protein XP_001398656.1 400459 D 5061 CDS An18g01980 4989758 401912..404227 VIII 1 NT_166533.1 Function: spb4 of S. cerevisiae is involved in the assembly of the ribosomal large subunit and maintenance by regulating the maturation of 25S ribosomal RNA.; Phenotype: aberrant production of 25S ribosomal RNA occurring in spb4-1 mutants of S. cerevisiae.; Remark: YFL002c is a synonym for spb4.; Similarity: the ORF shows similarity to several ATP-dependent RNA helicases and other DEAD box-containing proteins.; Title: strong similarity to ATP-dependent RNA helicase Spb4 - Saccharomyces cerevisiae; nucleus; See PMID 8774901; See PMID 9769101; See PMID 2408148; uncharacterized protein 404227 4989758 An18g01980 Aspergillus niger uncharacterized protein XP_001398657.1 401912 D 5061 CDS An18g01990 4989759 complement(join(404264..405329,405379..405635)) VIII 1 NT_166533.1 Remark: the ORF contains WD-repeats, which are found in some eukaryotic proteins with a wide variety of crucial functions.; Title: strong similarity to hypothetical WD-repeat protein SPAC1006.02 - Schizosaccharomyces pombe; See PMID 10322433; uncharacterized protein 405635 4989759 An18g01990 Aspergillus niger uncharacterized protein XP_059605012.1 404264 R 5061 CDS An18g02000 4989760 complement(join(405680..405984,406107..406465,406544..406766,406826..407102)) VIII 1 NT_166533.1 Function: rta1 of S. cerevisiae confers resistance to 7-aminocholesterol, a strong inhibitor of yeast and of Gram+-bacteria proliferation.; Title: similarity to 7-aminocholesterol resistance protein Rta1 - Saccharomyces cerevisiae; See PMID 8660468; uncharacterized protein 407102 4989760 An18g02000 Aspergillus niger uncharacterized protein XP_059605013.1 405680 R 5061 CDS An18g02010 4989761 join(408557..408563,408647..409015,409078..409175,409238..410080,410131..410217,410268..410514,410569..410800,410856..411048,411102..411191) VIII 1 NT_166533.1 Similarity: belongs to the RAD2/XPG family of excision repair endonucleases.; Title: strong similarity to hypothetical excision repair DNase SPAC955.02c - Schizosaccharomyces pombe; uncharacterized protein 411191 4989761 An18g02010 Aspergillus niger uncharacterized protein XP_001398660.1 408557 D 5061 CDS An18g02020 4989762 join(411692..412202,412269..412837) VIII 1 NT_166533.1 Function: tigA of A. niger is thought to be involved in the maturation of secretory proteins.; Gene-ID: tigA; Similarity: tigA of A. niger contains two thioredoxin domains.; endoplasmatic reticulum; See PMID 9256071; disulfide isomerase tigA-Aspergillus niger 412837 tigA 4989762 tigA Aspergillus niger disulfide isomerase tigA-Aspergillus niger XP_001398661.1 411692 D 5061 CDS An18g02030 4989763 complement(join(413199..413359,413436..413535,413624..413677)) VIII 1 NT_166533.1 Title: similarity to hypothetical protein P0038C05.1 - Oryza sativa; uncharacterized protein 413677 4989763 An18g02030 Aspergillus niger uncharacterized protein XP_001398662.1 413199 R 5061 CDS An18g02040 84593656 join(414522..414561,414753..414816,414874..414940) VIII 1 NT_166533.1 Title: questionable ORF; uncharacterized protein 414940 84593656 An18g02040 Aspergillus niger uncharacterized protein XP_059605014.1 414522 D 5061 CDS An18g02050 4989765 join(415214..415384,415438..415497,415537..415691,415758..415911,415970..416601,416649..416661,416707..416910) VIII 1 NT_166533.1 Similarity: belongs to the 1-aminocyclopropane-1-carboxylate oxidase superfamily.; Similarity: contains an iron/ascorbate oxidoreductase domain.; Title: strong similarity to hypothetical protein 15E6.100 - Neurospora crassa; uncharacterized protein 416910 4989765 An18g02050 Aspergillus niger uncharacterized protein XP_059605015.1 415214 D 5061 CDS An18g02060 4989766 complement(417350..419167) VIII 1 NT_166533.1 Function: samB of A. nidulans is involved in the control of polarized growth.; Function: whether samB of A. nidulans regulates polarized growth directly or on the transcriptional level remains uncertain.; Localization: samB of A. nidulans was observed in the cytoplasm in a granular distribution.; Similarity: contains a MYND-type zinc finger domain in the C-terminus.; Title: strong similarity to zinc-finger protein samB - Aspergillus nidulans; See PMID 9427754; uncharacterized protein 419167 4989766 An18g02060 Aspergillus niger uncharacterized protein XP_001398665.1 417350 R 5061 CDS An18g02070 84593657 join(419644..419668,419746..419854,419893..420279,420372..420501,420831..420883,420939..421197) VIII 1 NT_166533.1 hypothetical protein 421197 84593657 An18g02070 Aspergillus niger hypothetical protein XP_059605016.1 419644 D 5061 CDS An18g02080 84593658 complement(join(422320..422499,422597..422709,422784..422884,422992..423184,423298..423345,423464..423511,423564..423700,424059..424185,424278..424521,424600..424620)) VIII 1 NT_166533.1 Title: weak similarity to nuclear receptor NHR-21a -Caenorhabditis elegans; uncharacterized protein 424620 84593658 An18g02080 Aspergillus niger uncharacterized protein XP_059605017.1 422320 R 5061 CDS An18g02090 4989769 join(425626..425740,425877..426589,426647..426736,426804..426923,426994..427014) VIII 1 NT_166533.1 Complex: sfaD of A. nidulans is the beta-subunit of the heterotrimeric G-protein.; Function: sfaD of A. nidulans is required for normal vegetative growth and repression of sporulation.; Pathway: sfaD of A. nidulans is involved in growth signaling of asexual development.; Title: strong similarity to G-protein beta subunit sfaD - Aspergillus nidulans; See PMID 10523303; uncharacterized protein 427014 4989769 An18g02090 Aspergillus niger uncharacterized protein XP_001398668.1 425626 D 5061 CDS An18g02100 84593659 complement(join(428110..428337,428427..428563,428667..428856)) VIII 1 NT_166533.1 Title: weak similarity to hypothetical proline-rich protein At2g14890 - Arabidopsis thaliana; uncharacterized protein 428856 84593659 An18g02100 Aspergillus niger uncharacterized protein XP_059605018.1 428110 R 5061 CDS An18g02110 4989771 join(429830..430420,430486..430791) VIII 1 NT_166533.1 Function: BDM-1 of C. parasitica acts as a positive regulator of G-beta function.; Pathway: BDM-1 of C. parasitica is involved in fungal virulence signaling.; Similarity: belongs to the phosducin superfamily of G-beta modulators.; Title: strong similarity to G-protein beta subunit-interacting protein BDM-1 - Cryphonectria parasitica; See PMID 10618432; uncharacterized protein 430791 4989771 An18g02110 Aspergillus niger uncharacterized protein XP_059605019.1 429830 D 5061 CDS An18g02120 84593660 join(430929..430972,431064..431481) VIII 1 NT_166533.1 hypothetical protein 431481 84593660 An18g02120 Aspergillus niger hypothetical protein XP_059605020.1 430929 D 5061 CDS An18g02130 4989773 complement(join(432062..432150,432215..432335,432411..432551,432613..432758,432889..433040,433295..433335,433465..433473)) VIII 1 NT_166533.1 Complex: TFG3 of S. cerevisiae forms part of the heterotrimeric TFIIF.; Function: TFG3 of S. cerevisiae is a nonessential stimulating subunit of TFIIF.; Function: TFG3 of S. cerevisiae is identical to ANC1 implicated in actin cytoskeletal assembly and/or function.; Function: TFIIF of S. cerevisiae binds to RNA polymerase II decreasing it's affinity to nonspecific DNA and enabling efficient transcription initiation.; Remark: synonyms for TFG3 from S. cerevisiae are ANC1, TAF30, SWP29 and YPL129w.; Title: strong similarity to small subunit of transcription initiation factor TFIIF Tfg3 - Saccharomyces cerevisiae; nucleus; See PMID 7995524; uncharacterized protein 433473 4989773 An18g02130 Aspergillus niger uncharacterized protein XP_001398672.1 432062 R 5061 CDS An18g02140 4989774 complement(join(434489..434559,434620..434748,434805..435063,435266..435562)) VIII 1 NT_166533.1 Function: sbp1p of S. pombe is involved in the control of mitotic exit.; Function: sbp1p of S. pombe regulates spi1p GTPase activity.; Remark: a splice site was detected upstream of the START codon.; Similarity: belongs to the family of Ran-GTPase binding proteins which are implicated in the regulation of nuclear transport, including RNA export into the cytoplasm.; Title: strong similarity to spi1-GTPase binding protein sbp1p - Schizosaccharomyces pombe; See PMID 9504913; uncharacterized protein 435562 4989774 An18g02140 Aspergillus niger uncharacterized protein XP_001398673.1 434489 R 5061 CDS An18g02150 4989775 complement(436134..438668) VIII 1 NT_166533.1 Title: similarity to hypothetical protein CAF05965.1 - Neurospora crassa; uncharacterized protein 438668 4989775 An18g02150 Aspergillus niger uncharacterized protein XP_001398674.1 436134 R 5061 CDS An18g02160 84593661 join(439144..439177,439313..439563) VIII 1 NT_166533.1 Title: questionable ORF; uncharacterized protein 439563 84593661 An18g02160 Aspergillus niger uncharacterized protein XP_059605021.1 439144 D 5061 CDS An18g02170 4989777 complement(join(440594..440935,440994..441399,441455..441541,441593..441994,442061..442332)) VIII 1 NT_166533.1 Catalytic activity: Ktr5p of S. cerevisiae transfers an alpha-D-mannosyl residue from GDP-mannose to the lipid-linked oligosaccharide precursor.; Function: Ktr5p of S. cerevisiae participates in the formation of the lipid-linked oligosaccharide precursor for N-glycosilation.; Pathway: Ktr5p of S. cerevisiae is involved in the N-glycosilation pathway.; Phenotype: ktr5 mutants of of S. cerevisiae display cell wall defects.; Remark: the systematic gene name of KTR5 of S. cerevisiae is YNL029c.; Similarity: belongs to the KRE2 family of mannosyltransferases.; Title: strong similarity to mannosyltransferase Ktr5 - Saccharomyces cerevisiae; See PMID 9090056; See PMID 9878809; uncharacterized protein 442332 4989777 An18g02170 Aspergillus niger uncharacterized protein XP_001398676.1 440594 R 5061 CDS An18g02180 84593662 complement(join(443402..443533,443802..443843)) VIII 1 NT_166533.1 Title: questionable ORF; uncharacterized protein 443843 84593662 An18g02180 Aspergillus niger uncharacterized protein XP_059605022.1 443402 R 5061 CDS An18g02190 4989779 join(445848..446093,446150..446881,446913..447203) VIII 1 NT_166533.1 Title: similarity to hypothetical protein CAC39321.1 - Schizosaccharomyces pombe; uncharacterized protein 447203 4989779 An18g02190 Aspergillus niger uncharacterized protein XP_059605023.1 445848 D 5061 CDS An18g02200 4989780 complement(join(447876..448193,448291..448718,448784..448856,448921..448926,448991..449350,449433..449552)) VIII 1 NT_166533.1 Title: strong similarity to lung cancer associated polypeptide SEQ ID NO:723 from patent WO200055180-A2 - Homo sapiens; uncharacterized protein 449552 4989780 An18g02200 Aspergillus niger uncharacterized protein XP_001398679.1 447876 R 5061 CDS An18g02210 4989781 complement(join(<450430..450539,450596..450743,450830..451009,451077..451176,451239..451292,451375..451404)) VIII 1 NT_166533.1 Catalytic activity: dGTP + H2O = deoxyguanosine + triphosphate.; Function: protein transport. probably involved in vesicular traffic (by similarity).; Remark: Rab7 is a small GTP-ase localized on late endosomes, which regulates late endocytic membrane traffic in mammalian cells. This protein has a fundamental role in the cellular vacuolation induced by the cytotoxin VacA of Helicobacter pylori.; Remark: putative sequencing error at position 6018,1 bases too much.; Remark: strong similarity to Aspergillus niger EST AN03A11.; Similarity: to ras proteins. belongs to the rab subfamily.; Title: strong similarity to ras related protein Rab7 - Homo sapiens [putative frameshift]; putative frameshift; See PMID 8954989; See PMID 9126495; uncharacterized protein 451404 4989781 An18g02210 Aspergillus niger uncharacterized protein XP_059605024.1 450430 R 5061 CDS An18g02220 4989782 join(451911..451995,452084..452463,452523..452681) VIII 1 NT_166533.1 Remark: similarity to human GTPase associated protein-22 patent WO200031263-A2.; Title: similarity to GTPase associated protein-22 from patent WO200031263-A2 - Homo sapiens; uncharacterized protein 452681 4989782 An18g02220 Aspergillus niger uncharacterized protein XP_059605025.1 451911 D 5061 CDS An18g02230 4989783 complement(join(453231..453787,453857..455537,455604..455753,455813..455830)) VIII 1 NT_166533.1 Complex: Spb1p is associated in vivo with the nucleolar proteins Nop1p and Nop5/58p.; Remark: Spb1p is able to bind [(3)H]AdoMet in vitro,suggesting that it is a methylase.; Remark: Spb1p is required for proper assembly of pre-ribosomal particles during the biogenesis of 60S ribosomal subunits.; Remark: alternative name is YCL054w.; Title: strong similarity to methylase Spb1 -Saccharomyces cerevisiae; See PMID 10648622; See PMID 10556316; uncharacterized protein 455830 4989783 An18g02230 Aspergillus niger uncharacterized protein XP_001398682.1 453231 R 5061 CDS An18g02240 4989784 join(456329..456472,456550..458445,458504..458583,458643..458792,458858..459113) VIII 1 NT_166533.1 Title: similarity to hypothetical protein YML020w -Saccharomyces cerevisiae; uncharacterized protein 459113 4989784 An18g02240 Aspergillus niger uncharacterized protein XP_001398683.1 456329 D 5061 CDS An18g02250 4989785 complement(join(459901..459980,460184..461123,461196..461264,461318..461338,461412..461988,462044..462248,462302..462414,462708..462809,462890..463035)) VIII 1 NT_166533.1 Title: strong similarity to hypothetical protein encoded by An01g14540 - Aspergillus niger; uncharacterized protein 463035 4989785 An18g02250 Aspergillus niger uncharacterized protein XP_059605026.1 459901 R 5061 CDS An18g02260 84593663 complement(join(464206..464359,464420..464553,464740..464787)) VIII 1 NT_166533.1 hypothetical protein 464787 84593663 An18g02260 Aspergillus niger hypothetical protein XP_059605027.1 464206 R 5061 CDS An18g02270 4989787 complement(464960..466474) VIII 1 NT_166533.1 Remark: alternative name is YKR019c.; Remark: transcriptional silencing in S. cerevisiae occurs at several genetic loci, including the ribosomal DNA (rDNA). IRS4 is a protein with increased rDNA silencing (irs) phenotype.; Title: similarity to increased rDNA silencing protein Irs4 - Saccharomyces cerevisiae; See PMID 10082585; See PMID 10375630; uncharacterized protein 466474 4989787 An18g02270 Aspergillus niger uncharacterized protein XP_001398686.3 464960 R 5061 CDS An18g02280 4989788 join(468329..468359,468455..468698,468831..470373,470432..470698,470750..470875,470925..471872) VIII 1 NT_166533.1 Remark: Colletotrichum lagenarium and Magnaporthe grisea are plant pathogenic fungi that produce melanin during the appressorial differentiation stage of conidial germination and during the late stationary phase of mycelial growth. CMR1 (Colletotrichum melanin regulation) and PIG1 (pigment of Magnaporthe), that are involved in melanin biosynthesis. Both Cmr1p and Pig1p contain two distinct DNA-binding motifs, a Cys2His2 zinc finger motif and a Zn(II)2Cys6 binuclear cluster motif. The presence of both these motifs in a single transcriptional regulatory protein is unique among known eukaryotic transcription factors. Deletion of CMR1 in C. lagenarium caused a defect in mycelial melanization, but not in appressorial melanization.; Title: strong similarity to melanin regulator CMR1 -Colletotrichum lagenarium; See PMID 11123670; uncharacterized protein 471872 4989788 An18g02280 Aspergillus niger uncharacterized protein XP_059605028.1 468329 D 5061 CDS An18g02290 84593664 join(473399..473562,473645..473699) VIII 1 NT_166533.1 hypothetical protein 473699 84593664 An18g02290 Aspergillus niger hypothetical protein XP_059605029.1 473399 D 5061 CDS An18g02300 84593665 join(474900..474981,475052..475131,475256..475312) VIII 1 NT_166533.1 hypothetical protein 475312 84593665 An18g02300 Aspergillus niger hypothetical protein XP_059605030.1 474900 D 5061 CDS An18g02305 4989791 complement(join(477232..477321,477466..478950)) VIII 1 NT_166533.1 hypothetical protein 478950 4989791 An18g02305 Aspergillus niger hypothetical protein XP_059605031.1 477232 R 5061 CDS An18g02310 84593666 complement(join(478953..479530,479928..479986,480022..480446)) VIII 1 NT_166533.1 hypothetical protein 480446 84593666 An18g02310 Aspergillus niger hypothetical protein XP_059605032.1 478953 R 5061 CDS An18g02320 84593667 complement(join(481523..481900,481967..482109,482154..482190)) VIII 1 NT_166533.1 Function: BioF of E. herbicola is involved in the first step of biotin biosynthesis.; Pathway: BioF enzymes are involved in the biotin metabolism.; Similarity: the ORF shows similarity to several pyridoxal-phosphate-dependent aminotransferases.; Title: similarity to 8-amino-7-oxononanoate synthase BioF - Erwinia herbicola; See PMID 11133432; uncharacterized protein 482190 84593667 An18g02320 Aspergillus niger uncharacterized protein XP_059605033.1 481523 R 5061 CDS An18g02330 4989794 join(484775..484948,485004..485058,485113..486073,486129..486497,486533..486554,486569..>487093) VIII 1 NT_166533.1 Function: nirA of A. nidulans is a zinc finger transcription factor mediating nitrate induction of genes involved in nitrate assimilation (nitrate reductase,nitrite reductases and a nitrate permease, niaD, niiA and crnA, respectively).; Remark: C-terminally truncated ORF due to the end of contig.; Remark: the nitrate assimilation genes are induced by nitrate and repressed by ammonium at the transcriptional level.; Similarity: the nirA protein from A. nidulans is a zinc finger transcription factor of the fungal Zn(2)-Cys(6) binuclear cluster domain type.; Title: strong similarity to nitrate assimilation regulatory protein nirA - Aspergillus nidulans [truncated ORF]; nucleus; See PMID 1756977; See PMID 1922075; uncharacterized protein 487093 4989794 An18g02330 Aspergillus niger uncharacterized protein XP_059605034.1 484775 D 5061 CDS An18g02340 84593668 <487241..487726 VIII 1 NT_166533.1 Function: nirA of A. nidulans is a zinc finger transcription factor mediating nitrate induction of genes involved in nitrate assimilation (nitrate reductase,nitrite reductases and a nitrate permease, niaD, niiA and crnA, respectively).; Remark: N-terminally truncated ORF due to the end of contig.; Remark: the nitrate assimilation genes are induced by nitrate and repressed by ammonium at the transcriptional level.; Similarity: the nirA protein from A. nidulans is a zinc finger transcription factor of the fungal Zn(2)-Cys(6) binuclear cluster domain type.; Title: strong similarity to nitrate assimilation regulatory protein nirA - Aspergillus nidulans [truncated ORF]; nucleus; See PMID 1756977; See PMID 1922075; uncharacterized protein 487726 84593668 An18g02340 Aspergillus niger uncharacterized protein XP_059602888.1 487241 D 5061 CDS An18g02350 4989796 complement(join(488764..488826,488929..489316,489584..490128)) VIII 1 NT_166533.1 Catalytic activity: a phosphoprotein + H(2)O <=> a protein + phosphate.; Function: the human PPX protein phosphatase could be involved in microtubule organization. It is also suggested to be involved in activation of Rel family transcription factors (c-Rel/NF-kappaB).; Localization: cytoplasmic, nuclear and centrosomes.; Remark: alternate names for the human PPX protein phosphatase: PPP4C or PPP4.; Title: strong similarity to protein phosphatase X PPX - Homo sapiens; See PMID 9837938; See PMID 10769191; uncharacterized protein 490128 4989796 An18g02350 Aspergillus niger uncharacterized protein XP_059602889.1 488764 R 5061 CDS An18g02360 4989797 join(491763..491925,492024..492493,492566..493162) VIII 1 NT_166533.1 Function: S. cerevisiae Alg3 adds the first Dol-P-Man derived mannose in an alpha 1,3 linkage to Man5GlcNAc2-PP-Dol.; Pathway: S. cerevisiae Alg3 is involved in the dolichol dependent protein glycosylation in the ER.; Remark: alternate names for S. cerevisiae Alg3: Rhk1 or YBL082C.; Title: strong similarity to Dol-P-Man dependent alpha(1-3) mannosyltransferase Alg3 - Saccharomyces cerevisiae; See PMID 8842708; See PMID 10660594; uncharacterized protein 493162 4989797 An18g02360 Aspergillus niger uncharacterized protein XP_059602890.1 491763 D 5061 CDS An18g02370 4989798 complement(join(493327..493432,493486..493796)) VIII 1 NT_166533.1 Title: similarity to hypothetical protein SPBC146.08c - Schizosaccharomyces pombe; uncharacterized protein 493796 4989798 An18g02370 Aspergillus niger uncharacterized protein XP_001398697.1 493327 R 5061 CDS An18g02380 4989799 join(494499..494707,494787..495984) VIII 1 NT_166533.1 Remark: the GluP gene from Brucella abortus strain 2308 was isolated by functional complementation of Escherichia coli strains lacking either glucose or galactose transport systems.; Title: similarity to glucose/galactose transporter GluP - Brucella abortus; See PMID 9168605; uncharacterized protein 495984 4989799 An18g02380 Aspergillus niger uncharacterized protein XP_001398698.3 494499 D 5061 CDS An18g02390 84593669 complement(join(497007..497098,497241..497340)) VIII 1 NT_166533.1 Title: questionable ORF; uncharacterized protein 497340 84593669 An18g02390 Aspergillus niger uncharacterized protein XP_059602891.1 497007 R 5061 CDS An18g02400 4989801 join(497950..498382,498466..498732,498814..499395,499445..499840,499906..500319,500380..500908,500965..501166,501218..501623,501681..501742) VIII 1 NT_166533.1 Catalytic activity: ATP + protein <=> ADP + O-phosphoprotein.; Gene-ID: pkcA; deleted EC_number 2.7.1.37; See PMID 8569684; protein kinase C pkcA-Aspergillus niger 501742 pkcA 4989801 pkcA Aspergillus niger protein kinase C pkcA-Aspergillus niger XP_001398700.1 497950 D 5061 CDS An18g02410 4989802 502445..504553 VIII 1 NT_166533.1 Function: the rat Nopp140 protein is related to nucleologenesis and may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. It has intrinsic GTPase and ATPase activities. It may play an important role in transcription catalyzed by RNA polymerase I.; Title: similarity to nucleolus-cytoplasm shuttle phosphoprotein Nopp140 - Rattus norvegicus; nucleus; See PMID 10679015; See PMID 1623516; uncharacterized protein 504553 4989802 An18g02410 Aspergillus niger uncharacterized protein XP_059602892.1 502445 D 5061 CDS An18g02420 84593670 join(506307..506460,506592..506650,506768..506776) VIII 1 NT_166533.1 hypothetical protein 506776 84593670 An18g02420 Aspergillus niger hypothetical protein XP_059602893.1 506307 D 5061 CDS An18g02430 84593671 complement(join(507060..507269,507349..507512,507651..507820,508081..508156,508249..508348,508433..508578,508648..508678,508736..508807)) VIII 1 NT_166533.1 hypothetical protein 508807 84593671 An18g02430 Aspergillus niger hypothetical protein XP_059602894.1 507060 R 5061 CDS An18g02440 4989805 join(510439..510612,510704..510769,510824..511828,511910..513209,513256..513538,513603..513923,513972..514236) VIII 1 NT_166533.1 Function: the bovine cofactor D is a tubulin-specific chaperone protein involved in the assembly of the alpha/beta-tubulin heterodimers.; Title: strong similarity to tubulin-folding cofactor D - Bos taurus; cytoplasm; See PMID 10831612; See PMID 8706133; uncharacterized protein 514236 4989805 An18g02440 Aspergillus niger uncharacterized protein XP_059602895.1 510439 D 5061 CDS An18g02460 4989807 join(514780..514823,514912..514942,514991..515297,515394..515779) VIII 1 NT_166533.1 Complex: U1A belongs to the spliceosome where it is associated with sn-RNA U1.; Function: the human U1A protein binds to the stem loop II of U1 snRNA. it is the first sn-RNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 sn-RNP and the U4/U6/U5 tri-sn-RNP.; Similarity: the ORF DNA sequence shows also strong similarity to the EST an_3162 from A. niger.; Title: strong similarity to U1 snRNP-specific protein U1A - Homo sapiens; nucleus; See PMID 1833186; uncharacterized protein 515779 4989807 An18g02460 Aspergillus niger uncharacterized protein XP_059602896.1 514780 D 5061 CDS An18g02470 4989808 complement(join(516078..516307,516356..516396,516448..516457,516509..516557,516610..516935,516997..517007,517073..517185,517242..517262)) VIII 1 NT_166533.1 Complex: N. crassa Vma-8 belongs to the v-ATPase an heteromultimeric enzyme composed of a peripheral catalytic v1 complex (components A to H) attached to an integral membrane v0 proton pore complex (components: A, C, C', C'' and D).; Function: N. crassa Vma-8 is a subunit of the peripheral v1 complex of vacuolar ATPase (v-ATPase). The V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.; Title: strong similarity to vacuolar ATPase subunit D Vma-8 - Neurospora crassa; vacuole; See PMID 10340846; uncharacterized protein 517262 4989808 An18g02470 Aspergillus niger uncharacterized protein XP_059602897.1 516078 R 5061 CDS An18g02480 4989809 join(517907..520086,520141..520429) VIII 1 NT_166533.1 Function: the human XAB2 protein is involved in transcription-coupled DNA repair.; Title: strong similarity to DNA repair protein XAB2 - Homo sapiens; nucleus; See PMID 10944529; uncharacterized protein 520429 4989809 An18g02480 Aspergillus niger uncharacterized protein XP_059602898.1 517907 D 5061 CDS An18g02490 4989810 complement(join(521478..521828,521883..522265,522318..522424,522483..522871,522923..523268,523323..526264,526355..526501)) VIII 1 NT_166533.1 Function: S. cerevisiae Gea2 activates the ARF proteins by exchanging bound GDP for free GTP. Gea1(YJR031C) and Gea2 are functionally interchangeable.; Remark: alternate name for S. cerevisiae Gea2: YEL022W.; Remark: the ADP-ribosylation factor ARF is a small GTP-binding protein that is involved in the transport of vesicles between the endoplasmic reticulum (ER) and Golgi complex and within the Golgi complex itself. ARF cycles between inactive and membrane-associated active forms as a result of exchange of bound GDP for GTP; the GTP-bound form is an essential participant in the formation of transport vesicles.; Title: strong similarity to ARF guanine-nucleotide exchange factor 2 Gea2 - Saccharomyces cerevisiae; intracellular transport vesicles; See PMID 8945477; See PMID 10198630; See PMID 10430582; uncharacterized protein 526501 4989810 An18g02490 Aspergillus niger uncharacterized protein XP_059602899.1 521478 R 5061 CDS An18g02500 84593672 complement(join(526578..526735,527546..527673,527987..528037,528137..528238,528337..528603,528704..528792,528868..528933)) VIII 1 NT_166533.1 Remark: blastp with the predicted A. niger protein only retrieves random hits to lysine and glutamic acid rich proteins.; hypothetical protein 528933 84593672 An18g02500 Aspergillus niger hypothetical protein XP_059602900.1 526578 R 5061 CDS An18g02510 4989812 join(528935..531164,531216..533074,533147..533707) VIII 1 NT_166533.1 Remark: the genemodel of the predicted A. niger protein shows no obvious possibility to generate two independent ORFs.; Remark: the predicted A. niger protein shows similarity to S. pombe SPAC31A2. 16 in its N-terminal 500 aa, while its C-terminal aa 1200-1350 show similarity to filament proteins.; Title: similarity to hypothetical protein SPAC31A2.16 - Schizosaccharomyces pombe; uncharacterized protein 533707 4989812 An18g02510 Aspergillus niger uncharacterized protein XP_001398710.1 528935 D 5061 CDS An18g02520 4989813 complement(join(534139..535748,535814..535996,536046..536190)) VIII 1 NT_166533.1 Title: similarity to hypothetical protein B13N20.300 - Neurospora crassa; uncharacterized protein 536190 4989813 An18g02520 Aspergillus niger uncharacterized protein XP_001398711.1 534139 R 5061 CDS An18g02530 84593673 join(536952..537261,537892..538007,538296..538435,538876..538987) VIII 1 NT_166533.1 hypothetical protein 538987 84593673 An18g02530 Aspergillus niger hypothetical protein XP_059602901.1 536952 D 5061 CDS An18g02540 84593674 complement(538995..539339) VIII 1 NT_166533.1 Title: weak similarity to protein from patent WO9737044-A1 - Helicobacter pylori; uncharacterized protein 539339 84593674 An18g02540 Aspergillus niger uncharacterized protein XP_059602902.1 538995 R 5061 CDS An18g02550 4989816 complement(join(539374..541105,541184..541248)) VIII 1 NT_166533.1 Catalytic activity: dihydroxy-acid dehydratases catalyse the reaction, 2,3-dihydroxy-3-methylbutanoate <=> 3-methyl-2-oxobutanoate + H(2)O.; Function: S. cerevisiae ILV3 catalyzes the third step in biosynthesis of branched-chain amino acids.; Title: strong similarity to dihydroxy-acid dehydratase Ilv3 - Saccharomyces cerevisiae; See PMID 8299945; uncharacterized protein 541248 4989816 An18g02550 Aspergillus niger uncharacterized protein XP_059602903.1 539374 R 5061 CDS An18g02560 4989817 complement(join(541399..541505,541677..541692,541804..541918,542141..542656,542760..544298,544346..544528,544593..544696,544833..544934)) VIII 1 NT_166533.1 Function: in N. crassa, the fusion of hyphae of opposite mating type during vegetative growth results in growth inhibition and cell death, a process that is mediated by the tol locus.; Regulation: tol transcription is repressed to allow the coexistence of opposite mating-type nuclei during the sexual reproductive phase.; Remark: mutations in tol are recessive and suppress mating-type-associated heterokaryon incompatibility.; Title: similarity to vegetative incompatibility protein tol - Neurospora crassa; See PMID 9449795; See PMID 9927450; uncharacterized protein 544934 4989817 An18g02560 Aspergillus niger uncharacterized protein XP_059602904.1 541399 R 5061 CDS An18g02570 84593675 join(545057..545173,545261..545339,545575..545693,545716..545808) VIII 1 NT_166533.1 hypothetical protein 545808 84593675 An18g02570 Aspergillus niger hypothetical protein XP_059602905.1 545057 D 5061 CDS An18g02580 4989819 join(545810..546042,546098..546283,546339..546642,547182..547286) VIII 1 NT_166533.1 Remark: blastp with the predicted A. niger protein only retrieves random hits to glutamic acid rich proteins.; Title: weak similarity to hypothetical protein encoded by An12g00890 - Aspergillus niger; uncharacterized protein 547286 4989819 An18g02580 Aspergillus niger uncharacterized protein XP_001398717.3 545810 D 5061 CDS An18g02590 4989820 join(548364..548474,548556..549047,549110..549199) VIII 1 NT_166533.1 Similarity: shows some similarity to several serine/threonine-protein kinases.; Title: strong similarity to hypothetical protein encoded by An06g00610 - Aspergillus niger; uncharacterized protein 549199 4989820 An18g02590 Aspergillus niger uncharacterized protein XP_059605617.1 548364 D 5061 CDS An18g02600 4989821 550708..551565 VIII 1 NT_166533.1 hypothetical protein 551565 4989821 An18g02600 Aspergillus niger hypothetical protein XP_001398719.1 550708 D 5061 CDS An18g02610 4989822 complement(join(552550..552957,553052..556981,557156..557263,557336..557549,557645..557789,557939..558159,558203..558330)) VIII 1 NT_166533.1 Remark: the binding of the spectrin cytoskeleton to the cell plasma membrane depends on the large intracellular attachment protein ankyrin.; Title: similarity to ankyrin AAC37208.1 - Drosophila melanogaster; See PMID 7937942; uncharacterized protein 558330 4989822 An18g02610 Aspergillus niger uncharacterized protein XP_059605618.1 552550 R 5061 CDS An18g02620 10098283 join(558891..559011,559156..559951,560012..560177,560265..561537,561610..562043) VIII 1 NT_166533.1 hypothetical protein 562043 10098283 An18g02620 Aspergillus niger hypothetical protein XP_059605619.1 558891 D 5061 CDS An18g02630 4989824 join(562389..562634,562696..563715) VIII 1 NT_166533.1 Title: weak similarity to subtilisin J aprJ -Bacillus stearothermophilus; uncharacterized protein 563715 4989824 An18g02630 Aspergillus niger uncharacterized protein XP_001398722.1 562389 D 5061 CDS An18g02640 84593676 complement(join(563937..563999,564088..564184,564303..564365,565057..565155,565476..565480)) VIII 1 NT_166533.1 Title: questionable ORF; uncharacterized protein 565480 84593676 An18g02640 Aspergillus niger uncharacterized protein XP_059605620.1 563937 R 5061 CDS An18g02650 4989826 complement(join(565674..565790,565854..566314,566385..567279,567387..567548)) VIII 1 NT_166533.1 Remark: It is suggested that CFP (cercosporin facilitator protein) encodes a cercosporin transporter that contributes resistance to cercosporin by actively exporting it, thus maintaining low cellular concentrations of the toxin.; Similarity: shows similarity to several probable drug transport proteins.; Title: similarity to cercosporin transporter -Cercospora kikuchii; uncharacterized protein 567548 4989826 An18g02650 Aspergillus niger uncharacterized protein XP_059605621.1 565674 R 5061 CDS An18g02660 84593677 complement(join(567621..567733,567941..568072,568336..568439,568516..568581,569140..569213)) VIII 1 NT_166533.1 Title: questionable ORF; uncharacterized protein 569213 84593677 An18g02660 Aspergillus niger uncharacterized protein XP_059605622.1 567621 R 5061 CDS An18g02670 84593678 join(569292..569421,569513..569578,569729..569811) VIII 1 NT_166533.1 hypothetical protein 569811 84593678 An18g02670 Aspergillus niger hypothetical protein XP_059605623.1 569292 D 5061 CDS An18g02680 4989829 complement(join(570023..571465,571525..571563)) VIII 1 NT_166533.1 Function: the cytochrome P450 enzymes usually act as terminal oxidases in multicomponent electron transfer chains, called P450-containing monooxygenase systems.; Remark: the avnA gene of A. parasiticus encodes a fungal cytochrome P-450-type enzyme which is involved in the conversion of averantin to averufin in the aflatoxin biosynthetic pathway in A. parasiticus.; Similarity: shows similarity to several cytochrome P450 monooxygenases.; Title: strong similarity to cytochrome P450 monooxygenase avnA - Aspergillus parasiticus; See PMID 9097431; uncharacterized protein 571563 4989829 An18g02680 Aspergillus niger uncharacterized protein XP_059605624.1 570023 R 5061 CDS An18g02690 4989830 complement(join(572399..572518,572658..574225,574328..574586)) VIII 1 NT_166533.1 Remark: dihydrogeodin oxidase catalyzes the regio-and stereospecific phenol oxidative coupling reaction to form (+)-geodin from dihydrogeodin.; Similarity: shows also similarity to several laccases, phenol oxidases of different organisms.; Title: strong similarity to dihydrogeodin oxidase DHGO - Aspergillus terreus; See PMID 3032923; See PMID 7665560; uncharacterized protein 574586 4989830 An18g02690 Aspergillus niger uncharacterized protein XP_059605625.1 572399 R 5061 CDS An18g02700 4989831 complement(join(574957..576011,576070..576355,576414..576662)) VIII 1 NT_166533.1 Function: the cytochrome P450 enzymes usually act as terminal oxidases in multicomponent electron transfer chains, called P450-containing monooxygenase systems.; Similarity: shows similarity to several cytochrome P450 enzymes.; Title: similarity to cytochrome P-450 cyp509A1 -Cunninghamella elegans; See PMID 10867234; uncharacterized protein 576662 4989831 An18g02700 Aspergillus niger uncharacterized protein XP_001398729.1 574957 R 5061 CDS An18g02710 4989832 577902..580784 VIII 1 NT_166533.1 Remark: ent-Kaurene is the first cyclic diterpene intermediate of gibberellin biosynthesis in both plants and fungi.; Remark: in plants, ent-kaurene is synthesized from geranylgeranyl diphosphate via copalyl diphosphate in a two-step cyclization catalyzed by copalyl diphosphate synthase and ent-kaurene synthase.; Title: strong similarity to ent-Kaurene synthase -Phaeosphaeria sp.; See PMID 9268298; uncharacterized protein 580784 4989832 An18g02710 Aspergillus niger uncharacterized protein XP_001398730.3 577902 D 5061 CDS An18g02720 4989833 join(581602..581638,581737..581865,581936..582119,582201..582531) VIII 1 NT_166533.1 Catalytic activity: glutathione S-transferases catalyze the conversion of RX + Glutathione = HX + R-S-Glutathione.; Function: glutathione S-transferases (GST) conjugates reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.; Similarity: shows also some similarity to Ure2 of S. cerevisiae, which mediates nitrogen catabolite repression (NCR) of certain yeast genes.; Similarity: shows similarity to several putative glutathione S-transferases.; Title: strong similarity to hypothetical glutathione S-transferase CAA19067.1 - Schizosaccharomyces pombe; uncharacterized protein 582531 4989833 An18g02720 Aspergillus niger uncharacterized protein XP_059605626.1 581602 D 5061 CDS An18g02730 4989834 complement(join(584203..584671,584758..584975,585038..585196,585253..585525)) VIII 1 NT_166533.1 Localization: PTH11 of M. grisea was localised as a GFP-fusion protein in the cell membrane and in the vacuoles.; Phenotype: pth11 mutants of strain 4091-5-8 are nonpathogenic due to a defect in appressorium differentiation. This suggests that Pth11p functions at the cell cortex as an upstream effector of appressorium differentiation.; Title: similarity to transmembrane protein PTH11 -Magnaporthe grisea; See PMID 10521529; uncharacterized protein 585525 4989834 An18g02730 Aspergillus niger uncharacterized protein XP_001398732.1 584203 R 5061 CDS An18g02740 84593679 join(586606..587451,587549..588475) VIII 1 NT_166533.1 Function: the cytochrome P450 enzymes usually act as terminal oxidases in multicomponent electron transfer chains, called P450-containing monooxygenase systems.; Similarity: shows similarity to several cytochrome P450 enzymes.; Title: similarity to cytochrome P450 3A7 - Homo sapiens; See PMID 9328287; See PMID 9710705; uncharacterized protein 588475 84593679 An18g02740 Aspergillus niger uncharacterized protein XP_059605627.1 586606 D 5061 CDS An18g02750 4989836 complement(join(588750..589226,589420..589594,589653..589775,589838..589887)) VIII 1 NT_166533.1 Title: weak similarity to hypothetical methyltransferase AAO27746.2 - Fusarium sporotrichioides; uncharacterized protein 589887 4989836 An18g02750 Aspergillus niger uncharacterized protein XP_059605628.1 588750 R 5061 CDS An18g02752 4989837 590334..591521 VIII 1 NT_166533.1 Title: strong similarity to hypothetical protein BAC47708.1 - Bradyrhizobium japonicum; uncharacterized protein 591521 4989837 An18g02752 Aspergillus niger uncharacterized protein XP_001398735.1 590334 D 5061 CDS An18g02760 4989838 complement(join(592243..592425,592479..592787,592841..593717,593780..594388,594434..596475,596546..597422,597482..597654)) VIII 1 NT_166533.1 Similarity: the predicted A. niger protein shows local similarity to the hypothetical protein T21J18. 40 of A. thaliana. this domain is also found in the protein sequence of patent EP1033405-A2 (AC# AAG54045). however,the lengths of these entries differ by 104 amino acids.; Title: similarity to hypothetical protein T21J18.40 - Arabidopsis thaliana; uncharacterized protein 597654 4989838 An18g02760 Aspergillus niger uncharacterized protein XP_059605629.1 592243 R 5061 CDS An18g02770 4989839 complement(join(598684..598700,598847..599545,599602..599950)) VIII 1 NT_166533.1 Title: weak similarity to hypothetical protein encoded by An07g09090 - Aspergillus niger; uncharacterized protein 599950 4989839 An18g02770 Aspergillus niger uncharacterized protein XP_001398737.3 598684 R 5061 CDS An18g02780 84593680 join(601303..601403,601510..602557) VIII 1 NT_166533.1 Similarity: similarity of the predicted A. niger protein to various protein sequences is due to low complexity sequences.; Title: similarity to hypothetical protein encoded by An12g03140 - Aspergillus niger; uncharacterized protein 602557 84593680 An18g02780 Aspergillus niger uncharacterized protein XP_059605630.1 601303 D 5061 CDS An18g02790 84593681 complement(join(603860..604351,604405..604522,604604..604658,604908..604959)) VIII 1 NT_166533.1 hypothetical protein 604959 84593681 An18g02790 Aspergillus niger hypothetical protein XP_059605631.1 603860 R 5061 CDS An18g02800 4989842 join(605158..605262,605319..605551,605599..606169,606355..606630) VIII 1 NT_166533.1 Regulation: 2'-hydroxyisoflavone reductase from A. thaliana accumulates rapidly in Arabidopsis plants under various oxidative stress conditions, such as treatment with paraquat, t-butylhydroperoxide, diamide, and menadione.; Remark: the protein sequence of 2'-hydroxyisoflavone reductase from A. thaliana is covered by patent EP1033405-A2 (AC# AAG14147). the patent does not provide information about the function of the protein.; Similarity: the predicted A. niger protein shows similarity to 2'-hydroxyisoflavone reductase from A. thaliana and from many other plant and fungal species. the N-terminus of the predicted A. niger protein shows strong similarity to a translated mRNA (tomato pathotype-specific DNA fragment) from the fungus Verticillium dahliae.; Title: similarity to 2-hydroxyisoflavone reductase -Arabidopsis thaliana; See PMID 7592828; uncharacterized protein 606630 4989842 An18g02800 Aspergillus niger uncharacterized protein XP_059605632.1 605158 D 5061 CDS An18g02810 84593682 complement(join(607113..607165,607248..607460,607751..607850,607957..608011,608091..608121,608253..608306,608351..608439,608533..608613,608713..608823,609025..609122,609205..609282)) VIII 1 NT_166533.1 hypothetical protein 609282 84593682 An18g02810 Aspergillus niger hypothetical protein XP_059605633.1 607113 R 5061 CDS An18g02820 4989844 complement(join(609574..609679,609738..609741,610012..610549)) VIII 1 NT_166533.1 Title: questionable ORF; uncharacterized protein 610549 4989844 An18g02820 Aspergillus niger uncharacterized protein XP_001398742.3 609574 R 5061 CDS An18g02830 4989845 complement(join(611211..611471,611522..611824,611872..612866,612923..613133,613183..614419,614535..614665)) VIII 1 NT_166533.1 Title: strong similarity to hypothetical conserved protein B13N20.310 - Neurospora crassa; uncharacterized protein 614665 4989845 An18g02830 Aspergillus niger uncharacterized protein XP_059605634.1 611211 R 5061 CDS An18g02840 4989846 join(615650..616126,616184..616315) VIII 1 NT_166533.1 Title: strong similarity to hypothetical protein YML079w - Saccharomyces cerevisiae; uncharacterized protein 616315 4989846 An18g02840 Aspergillus niger uncharacterized protein XP_001398744.1 615650 D 5061 CDS An18g02850 4989847 complement(join(616470..617396,617499..617558)) VIII 1 NT_166533.1 Function: MRS3 (S. cer.) is essential for the splicing of group II introns and is also involved in processes of mitochondrial biogenesis other than RNA splicing.; Function: MRS3 (S. cer.) may act as a carrier,exerting its suppressor activity via modulation of solute concentrations in the mitochondria.; Function: the MRS3 gene product of S. cerevisiae probably is involved in splicing of aI1 intron for COB gene.; Similarity: the ORF encoded protein is a member of the mitochondrial carrier family.; Title: strong similarity to mtRNA splice defect-suppressing mitochondrial carrier Mrs3 -Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 2448588; See PMID 1703236; uncharacterized protein 617558 4989847 An18g02850 Aspergillus niger uncharacterized protein XP_001398745.1 616470 R 5061 CDS An18g02860 4989848 complement(join(618429..618677,618930..619213,619276..620653,620827..621125,621195..621204)) VIII 1 NT_166533.1 Function: NPR1 of S. cerevisiae promotes the activity of at least 6 distinct transport systems for nitrogenous nutrients under conditions of nitrogen catabolite derepression.; Remark: the systematic name for NPR1 of S. cerevisiae is YNL183C.; Similarity: the predicted A. niger protein shows strong similarity to nitrogen permease reactivator protein (NPR1) from S. cerevisiae. the carboxy-terminal region of NPR1 contains consensus sequences characteristic of the catalytic domains of protein kinases.; Title: strong similarity to nitrogen permease reactivator protein Npr1 - Saccharomyces cerevisiae; See PMID 2125693; uncharacterized protein 621204 4989848 An18g02860 Aspergillus niger uncharacterized protein XP_059605635.1 618429 R 5061 CDS An18g02870 84593683 complement(join(621728..622008,622082..622182,622457..622638)) VIII 1 NT_166533.1 hypothetical protein 622638 84593683 An18g02870 Aspergillus niger hypothetical protein XP_059605636.1 621728 R 5061 CDS An18g02880 84593684 complement(join(622865..622957,623083..623166,623277..623421,623498..623543,623634..623789,623807..623911,623998..624250)) VIII 1 NT_166533.1 hypothetical protein 624250 84593684 An18g02880 Aspergillus niger hypothetical protein XP_059605637.1 622865 R 5061 CDS An18g02890 4989851 complement(join(624646..624978,625094..625222)) VIII 1 NT_166533.1 Similarity: the predicted A. niger protein shows strong similarity to mitochondrial ribosomal protein L11 from S. cerevisiae and from many eucaryotic species as well as to procaryotic 50S ribosomal proteins L11.; Title: strong similarity to mitochondrial ribosomal protein of the large subunit L11 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9151978; mitochondrial 54S ribosomal protein uL11m 625222 4989851 An18g02890 Aspergillus niger mitochondrial 54S ribosomal protein uL11m XP_001398749.1 624646 R 5061 CDS An18g02900 4989852 join(625867..625893,625973..626163,626245..626669,626726..627102,627159..627257) VIII 1 NT_166533.1 Title: strong similarity to hypothetical protein SPAC8A4.09c - Schizosaccharomyces pombe; uncharacterized protein 627257 4989852 An18g02900 Aspergillus niger uncharacterized protein XP_059605638.1 625867 D 5061 CDS An18g02910 4989853 join(627644..627705,627791..627822,627881..627896,627984..628071,628123..628182,628250..628267,628297..628314) VIII 1 NT_166533.1 Complex: the nucleosome is an octamer containing two molecules of H2a, H2b, H3, and H4; which wrap approximatively 146 bp of DNA.; Function: histone H4, along with histone H3, plays a central role in nucleosome formation.; Similarity: the predicted A. niger protein shows similarity to histone H4 (HHF2) of S. cerevisiae and of many other eucaryotic organisms.; Title: similarity to histone H4 Hhf2 - Saccharomyces cerevisiae; nucleus; See PMID 9256430; uncharacterized protein 628314 4989853 An18g02910 Aspergillus niger uncharacterized protein XP_059605639.1 627644 D 5061 CDS An18g02920 84593685 complement(join(629026..629081,629177..629323,629408..629471,629570..629611,629717..629827,629932..630087,630530..630694)) VIII 1 NT_166533.1 hypothetical protein 630694 84593685 An18g02920 Aspergillus niger hypothetical protein XP_059605640.1 629026 R 5061 CDS An18g02930 84593686 complement(join(632063..632225,632361..632566)) VIII 1 NT_166533.1 hypothetical protein 632566 84593686 An18g02930 Aspergillus niger hypothetical protein XP_059605641.1 632063 R 5061 CDS An18g02940 4989856 complement(join(632962..633408,633469..645773,645843..646125)) VIII 1 NT_166533.1 Catalytic activity: ciliary dynein beta heavy chain of A. crassispina catalyses the reaction ATP + H(2)O = ADP + phosphate.; Complex: ciliary dynein consists of two heavy chains (alpha and beta), three intermediate chains and several light chains.; Function: ciliary dynein beta heavy chain of A. crassispina is a force generating motor protein of eukaryotic cilia and flagella. it produces force towards the minus ends of microtubules. dynein has ATPase activity.; Regulation: dynein beta heavy chain mRNA of A. crassispina accumulates rapidly in response to deciliation.; Similarity: the predicted A. niger protein shows strong similarity to dynein heavy chains of A. crassispina and of many other eucaryotic organisms.; Title: strong similarity to ciliary dynein beta heavy chain - Anthocidaris crassispina; See PMID 1830928; See PMID 1693885; uncharacterized protein 646125 4989856 An18g02940 Aspergillus niger uncharacterized protein XP_059605642.1 632962 R 5061 CDS An18g02950 4989857 complement(join(646809..647105,647160..647546,647604..648135,648176..648576,648628..649698,649759..649918,649990..650058,650111..650152,650234..650292,650343..651024,651073..651180,651230..651495,651547..651650,651705..651898,651958..652181)) VIII 1 NT_166533.1 Remark: SIN1 of A. thaliana is required for normal ovule development. the SIN1 polynucleotide is useful for regulating flowering or fertility in plants. it is also useful for increasing fecundity of plants. the DNA molecule, which plays a vital role in fertility, seed production and flowering time control in plants, is useful as a tool for engineering the expression of genes involved in seed/embryo development and flowering time. it is particularly important in genetically engineering or controlling developmentally important plant processes,which is useful for improving crop plant production.; Similarity: the predicted A. niger protein shows strong similarity to the protein sequence short integuments 1 (SIN1) of patent WO200075359-A2 (AC# AAB31166) and several hypothetical RNA helicase of eucaryotic and procaryotic species.; Title: strong similarity to short integuments SIN1 from patent WO200075359-A2 - Arabidopsis thaliana; See PMID 8787738; See PMID 8948599; uncharacterized protein 652181 4989857 An18g02950 Aspergillus niger uncharacterized protein XP_059605643.1 646809 R 5061 CDS An18g02960 4989858 join(652756..653165,653229..653505,653564..654145) VIII 1 NT_166533.1 Complex: the alpha 4 protein of M. musculus binds to murine MB-1 protein and is also tightly associated with a kinase activity. murine MB-1 protein can be co-precipitated with the Ig receptor (IgR). thus, the alpha 4 gene-encoded molecule may be functionally involved in the IgR-mediated signal transduction in B cells.; Remark: the alpha 4 protein of M. musculus is inducibly phosphorylated by stimulation with 12-O-tetradecanoyl-phorbol-13-acetate.; Similarity: the predicted A. niger protein shows similarity to the alpha 4 protein of M. musculus and strong similarity to fungal hypothetical proteins.; Title: similarity to protein alpha 4 - Mus musculus; See PMID 7876543; uncharacterized protein 654145 4989858 An18g02960 Aspergillus niger uncharacterized protein XP_001398756.3 652756 D 5061 CDS An18g02970 4989859 complement(join(654422..655143,655209..655491)) VIII 1 NT_166533.1 Catalytic activity: hydroxymethylbilane synthase of S. cerevisiae catalyses the reaction: 4 porphobilinogen + H(2)O = hydroxymethylbilane + 4 NH(3).; Cofactor: hydroxymethylbilane synthase of S. cerevisiae requires dipyrromethane as a cofactor.; Pathway: hydroxymethylbilane synthase of S. cerevisiae is the third enzyme in the heme biosynthetic pathway.; Title: strong similarity to hydroxymethylbilane synthase Hem3 - Saccharomyces cerevisiae; See PMID 323256; See PMID 1508149; uncharacterized protein 655491 4989859 An18g02970 Aspergillus niger uncharacterized protein XP_001398757.1 654422 R 5061 CDS An18g02980 4989860 join(656259..656730,656813..659045,659099..659183) VIII 1 NT_166533.1 Catalytic activity: lonD of M. xanthus hydrolyses large proteins such as globin, casein and denaturated serum albumin in presence of ATP.; Function: lonD of M. xanthus degrades short-lived regulatory and abnormal proteins. lonD of M. xanthus is essential for fruiting body formation and development.; Inhibition: lonD of M. xanthus is inhibited by vanadate.; Similarity: the predicted A. niger protein shows strong similarity to endopeptidase La 2 (lonD) of M. xanthus, which belongs to peptidase family S16 also known as the lon family of ATP-dependent proteases.; Title: strong similarity to endopeptidase La 2 lonD - Myxococcus xanthus; cytoplasm; See PMID 8331082; See PMID 8331083; uncharacterized protein 659183 4989860 An18g02980 Aspergillus niger uncharacterized protein XP_059605644.1 656259 D 5061 CDS An18g02990 4989861 complement(join(659532..659742,659852..660142,660241..660329)) VIII 1 NT_166533.1 Complex: MRP20 of S. cerevisiae is a component of the 54 S subunit of the yeast mitochondrial ribosome.; Remark: the levels of the mRNAs and proteins for MRP20 is regulated in response to carbon source. in [rho0] strains lacking mitochondrial rRNA, the level of the protein is reduced severalfold, presumably because the unassembled proteins are unstable.; Similarity: the predicted A. niger protein shows similarity to MRP20 of S. cerevisiae, which is similar to members of the L23 family of ribosomal proteins.; Title: similarity to mitochondrial ribosomal protein Mrp20 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 1544898; mitochondrial 54S ribosomal protein uL23m 660329 4989861 An18g02990 Aspergillus niger mitochondrial 54S ribosomal protein uL23m XP_001398759.1 659532 R 5061 CDS An18g03000 4989862 complement(join(660643..661643,661715..661859,661925..661987)) VIII 1 NT_166533.1 Similarity: the predicted A. niger protein shows strong similarity to hypothetical protein sequences of diverse eucaryotic species and similarity to several procaryotic protein sequences.; Title: strong similarity to hypothetical protein SPBC1703.05 - Schizosaccharomyces pombe; uncharacterized protein 661987 4989862 An18g03000 Aspergillus niger uncharacterized protein XP_001398760.1 660643 R 5061 CDS An18g03010 4989863 complement(join(662680..662712,662766..665075,665132..665296,665363..665427,665530..665677)) VIII 1 NT_166533.1 Complex: human p97 also binds specifically to the intracellular domain of the p55 tumor necrosis factor (TNF) receptor.; Function: human p97 acts as a regulatory subunit of the 26S proteasome, which is involved in the ATP-dependent degradation of ubiquitinated proteins.; Remark: human p97 shows high sequence similarity with a yeast protein of unknown function, which is termed NAS1 (non-ATPase subunit 1, new gene name: RPN1). expression of the human p97 cDNA in nas1 disruptant yeast cells suppressed the growth defect of the mutants. culturing of the temperature-sensitive nas1 cells at the restrictive temperature promoted the accumulation polyubiquitinated cellular proteins, implying that the 26S proteasome requires a functional Nas1p subunit for ubiquitin-dependent proteolysis.; Remark: the nearly identical human 26S proteasome component P100 protein sequence is covered by patent JP09075082-A (AC# AAW15473).; Similarity: the predicted A. niger protein shows strong similarity to 26S proteasome regulatory subunit S2 (p97) (tumor necrosis factor type 1 receptor associated protein 2) of H. sapiens and other eucaryotic species.; Title: strong similarity to 26S proteasome regulatory subunit S2 - Homo sapiens; endoplasmatic reticulum; See PMID 7601280; See PMID 8774743; See PMID 9584156; See PMID 10664589; uncharacterized protein 665677 4989863 An18g03010 Aspergillus niger uncharacterized protein XP_001398761.1 662680 R 5061 CDS An18g03020 4989864 complement(join(666083..667239,667295..667546,667612..668092)) VIII 1 NT_166533.1 Title: similarity to hypothetical protein encoded by MUP24.12 - Arabidopsis thaliana; uncharacterized protein 668092 4989864 An18g03020 Aspergillus niger uncharacterized protein XP_059605645.1 666083 R 5061 CDS An18g03030 4989865 join(668751..668819,668871..669050,669106..669372,669428..671059,671172..671200,671244..671370) VIII 1 NT_166533.1 Complex: in the yeast S. cerevisiae, DNA mismatch repair requires the MSH2, MLH1, and PMS1 proteins. experiments revealed that the yeast MLH1 and PMS1 proteins physically associate, possibly forming a heterodimer, and that MLH1 and PMS1 act in concert to bind a MSH2-heteroduplex complex containing a G-T mismatch. thus,MSH2, MLH1, and PMS1 are likely to form a ternary complex during the initiation of eukaryotic DNA mismatch repair.; Function: disruption of the MLH1 gene of S. cerevisiae results in elevated spontaneous mutation rates during vegetative growth, dramatic increase in the instability of simple sequence repeats and causes increased spore lethality in diploid strains, presumably due to the accumulation of recessive lethal mutations and inefficient repair of heteroduplex DNA generated during genetic recombination.; Similarity: the predicted A. niger protein shows strong similarity to mismatch repair protein MLH1 of S. cerevisiae and other eucaryotic species as well as similarity to the procaryotic DNA mismatch repair protein mutL.; Title: strong similarity to mismatch repair protein Mlh1 - Saccharomyces cerevisiae; See PMID 8066446; See PMID 8264608; uncharacterized protein 671370 4989865 An18g03030 Aspergillus niger uncharacterized protein XP_059605646.1 668751 D 5061 CDS An18g03040 4989866 complement(join(671829..671955,672019..672075,672129..672249,672309..673337,673389..674139)) VIII 1 NT_166533.1 Function: XCL100(beta) of X. laevis is able to dephosphorylate both tyrosine and threonine residues of activated p42 MAP kinase in vitro.; Localization: XCL100(beta) proteins were localised predominantly in the nucleus in transfected COS-1 cells.; Regulation: XCL100(beta) of X. laevis is inducible by serum stimulation and oxidative/heat stress in a X. laevis kidney cell line. during early embryogenesis, levels of XCL100 mRNA are greatly increased at the mid-blastula transition, suggesting that this enzyme may be involved in the regulation of MAP kinase activity during early development.; Similarity: the predicted A. niger protein shows similarity to MAP kinase phosphatase XCL100(beta) protein of X. laevis, related proteins from other vertebrate species and from the plant A. thaliana. the predicted A. niger protein shows strong similarity to the probable protein-tyrosine-phosphatase of S. cerevisiae.; Title: similarity to MAP kinase phosphatase XCL100(beta) - Xenopus laevis; nucleus; See PMID 7593328; uncharacterized protein 674139 4989866 An18g03040 Aspergillus niger uncharacterized protein XP_059605647.1 671829 R 5061 CDS An18g03050 84593687 complement(join(675118..675265,675354..675498,675625..675738,675834..675875,676031..676064)) VIII 1 NT_166533.1 hypothetical protein 676064 84593687 An18g03050 Aspergillus niger hypothetical protein XP_059605648.1 675118 R 5061 CDS An18g03060 4989868 complement(join(677042..677500,677555..677845,677902..679583,679649..680013,680097..680314,680424..680528)) VIII 1 NT_166533.1 Function: the human leucine carboxyl methyltransferase LCMT methylates the carboxyl group of the c-terminal leucine residue of protein phosphatase 2a catalytic subunits (PPP2ca) to form alpha-leucine ester residues.; Similarity: the ORF encoded protein also shows strong similarity to the human cell signalling protein-9 from patent WO9958558-A2. The patent does not decribe its function clearly enough.; Similarity: the ORF encoded protein shows strong similarity to the probable S. cerevisiae methyltransferase Ppm2(YOL141w).; Title: similarity to leucine carboxyl methyltransferase LCMT - Homo sapiens; See PMID 10600115; uncharacterized protein 680528 4989868 An18g03060 Aspergillus niger uncharacterized protein XP_059605649.1 677042 R 5061 CDS An18g03070 4989869 join(681043..681094,681161..681315,681450..681609,681666..682546) VIII 1 NT_166533.1 Title: strong similarity to ORF2319 polynucleotide sequence SEQ ID NO:4637 from patent WO200058473-A2 - Homo sapiens; uncharacterized protein 682546 4989869 An18g03070 Aspergillus niger uncharacterized protein XP_001398767.3 681043 D 5061 CDS An18g03080 4989870 join(684064..684514,684600..684661,684762..684856,684888..685253,685308..685507,685576..685853) VIII 1 NT_166533.1 Catalytic activity: 6-Hydroxy-D-nicotine oxidases convert (R)-6-hydroxynicotine + H(2)O + O(2) to 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H(2)O(2).; Cofactor: FAD.; Pathway: degradation of nicotine.; Title: similarity to 6-hydroxy-d-nicotine oxidase 6-HDNO - Arthrobacter oxidans; See PMID 2115879; See PMID 2680607; See PMID 3622516; uncharacterized protein 685853 4989870 An18g03080 Aspergillus niger uncharacterized protein XP_059605650.1 684064 D 5061 CDS An18g03090 4989871 join(686504..687342,687421..687817) VIII 1 NT_166533.1 Title: strong similarity to hypothetical protein SPAC4G8.06c - Schizosaccharomyces pombe; uncharacterized protein 687817 4989871 An18g03090 Aspergillus niger uncharacterized protein XP_059605651.1 686504 D 5061 CDS An18g03100 4989872 complement(join(687964..688448,688534..688648)) VIII 1 NT_166533.1 Remark: alternate name for S. cerevisiae Ssp120: YLR250W.; Title: strong similarity to hypothetical precursor of secretory protein Ssp120 - Saccharomyces cerevisiae; extracellular/secretion proteins; See PMID 1743509; uncharacterized protein 688648 4989872 An18g03100 Aspergillus niger uncharacterized protein XP_001398770.1 687964 R 5061 CDS An18g03110 4989873 689097..691289 VIII 1 NT_166533.1 Similarity: the ORF is longer than H1 of O. cuniculus (730 compared to 606 amino acids). The alignment between the two proteins encompasses about 200 amino acids.; Similarity: the similarities of the ORF encoded protein to matching proteins are mainly based on repetitive structures.; Title: weak similarity to neurofilament triplet protein H1 - Oryctolagus cuniculus; uncharacterized protein 691289 4989873 An18g03110 Aspergillus niger uncharacterized protein XP_001398771.1 689097 D 5061 CDS An18g03120 4989874 complement(join(692229..692357,692419..694285,694355..694665)) VIII 1 NT_166533.1 Function: the S. cerevisiae pre-mRNA processing factor Prp43 is involved in disassembly of spliceosomes after the release of mature mRNA.; Remark: alternate name for S. cerevisiae Prp43: YGL120c.; Similarity: the ORF encoded protein and the S. cervisiae Prp43 protein belong to the 'DEAD' box family of helicases.; Title: strong similarity to ATP dependent RNA helicase and pre-mRNA splicing factor Prp43 - Saccharomyces cerevisiae; nucleus; See PMID 9342317; uncharacterized protein 694665 4989874 An18g03120 Aspergillus niger uncharacterized protein XP_001398772.1 692229 R 5061 CDS An18g03130 4989875 join(695345..695458,695514..695960,696051..696135,696202..696398,696507..696980,697125..697425,697486..697763,697827..698090) VIII 1 NT_166533.1 Function: S. pombe Skb1 is a suggested to be protein methyltransferase that positively controls the activity of the Shk1 protein kinase. The p21-activated kinase, Shk1,is required for cell viability, establishment and maintenance of cell polarity, and proper mating response in the fission yeast, Schizosaccharomyces pombe.; Title: strong similarity to shk1 interacting protein skb1p - Schizosaccharomyces pombe; See PMID 8943016; See PMID 9843966; See PMID 11278267; uncharacterized protein 698090 4989875 An18g03130 Aspergillus niger uncharacterized protein XP_059605652.1 695345 D 5061 CDS An18g03140 84593688 complement(join(698659..698849,699107..699117,699195..699386,699427..699461,699546..699569)) VIII 1 NT_166533.1 hypothetical protein 699569 84593688 An18g03140 Aspergillus niger hypothetical protein XP_059605653.1 698659 R 5061 CDS An18g03150 4989877 join(701156..701236,701360..703789) VIII 1 NT_166533.1 Function: the Podospora anserina cro1 gene is required for sexual sporulation.; Localization: GFP-tagging of the CRO1 protein from Podospora anserina reveals that it is a cytosolic protein mainly expressed at the beginning of the dikaryotic stage and at the time of ascospore maturation.; Title: strong similarity to protein CRO1 - Podospora anserina; cytoplasm; See PMID 9482722; uncharacterized protein 703789 4989877 An18g03150 Aspergillus niger uncharacterized protein XP_001398775.1 701156 D 5061 CDS An18g03160 84593689 complement(join(704130..704211,704261..704406,704533..704587,704712..704914,705126..705207,705383..705393)) VIII 1 NT_166533.1 hypothetical protein 705393 84593689 An18g03160 Aspergillus niger hypothetical protein XP_059605654.1 704130 R 5061 CDS An18g03170 4989879 join(706721..706856,706923..709736,709794..710194,710245..710487) VIII 1 NT_166533.1 Complex: Pho85(cyclin-dependent kinase)/Pho80(cyclin).; Function: the complex Pho85(cyclin-dependent kinase)/Pho80(cyclin) phophorylates the transcription factor Pho4. Phosphorylation of Pho4 by Pho80-Pho85 turns off PHO5 transcription by regulating the nuclear localization of Pho4.; Remark: a splice site was detected upstream of the START codon.; Similarity: the ORF encoded protein and S. cerevisiae Pho85 belong to the Ser/Thr family of protein kinases and to the cdc2/cdkx subfamily.; Title: strong similarity to cyclin-dependent protein kinase Pho85 - Saccharomyces cerevisiae; deleted EC_number 2.7.1.37; See PMID 8539622; See PMID 8918192; uncharacterized protein 710487 4989879 An18g03170 Aspergillus niger uncharacterized protein XP_001398777.1 706721 D 5061 CDS An18g03180 4989880 join(710980..711025,711115..712208) VIII 1 NT_166533.1 Catalytic activity: the human transcription initiation factor TFIIH shows DNA-dependent ATPase activity.; Complex: the human transcription initiation factor TFIIH contains four subunits p89(ERCC3), p80(ERCC2), p52,p35.; Function: TFIIH is involved in RNA polymerase II transcription initiation and in nucleotide excision DNA repair.; Title: strong similarity to subunit of transcription initiation factor TFIIH BTFII - Homo sapiens; nucleus; See PMID 1939143; See PMID 7511595; See PMID 8152490; uncharacterized protein 712208 4989880 An18g03180 Aspergillus niger uncharacterized protein XP_001398778.1 710980 D 5061 CDS An18g03190 4989881 complement(join(712582..712728,712773..712882,712934..713830,713901..714100,714166..714272)) VIII 1 NT_166533.1 Catalytic activity: (L-asparaginase) L-asparagine + H(2)O <=> L-aspartate + NH(3).; Similarity: the L-asparaginase from Lupinus arboreus belongs to the asparaginase 2 family.; Similarity: the ORF encoded protein only shows domain homology to the L-asparaginase from Lupinus arboreus. It is strong similar to the 'asparaginase related protein' B17C10. 180 from Neurospora crassa.; Title: similarity to L-asparaginase - Lupinus arboreus; See PMID 1377963; uncharacterized protein 714272 4989881 An18g03190 Aspergillus niger uncharacterized protein XP_001398779.1 712582 R 5061 CDS An18g03200 4989882 join(715435..715469,715541..715563,715628..715989,716058..716957) VIII 1 NT_166533.1 Function: disruption of the act2 gene from S. pombe demonstrated that this gene encodes a function essential for germination of haploid spores.; Title: strong similarity to actin like protein act2p - Schizosaccharomyces pombe; cytoskeleton; See PMID 1729722; uncharacterized protein 716957 4989882 An18g03200 Aspergillus niger uncharacterized protein XP_001398780.1 715435 D 5061 CDS An18g03210 4989883 join(717497..717828,717889..718328,718394..718560,718613..718750) VIII 1 NT_166533.1 Catalytic activity: NADPH + quinone <=> NADP(+) + semiquinone.; Cofactor: Zinc.; Function: quinone oxidoreductases are specific for NADPH and catalyzes the one election reduction of certain quinones substrate. The A. thaliana quinone oxidoreductase P1 also catalyzes the divalent reduction of diamide to 1,2-bis(N,N-dimethylcarbamoyl)hydrazine.; Remark: alternate names for the A. thaliana quinone oxidoreductase P1: NADPH:quinone reductase or Zeta-crystallin.; Title: strong similarity to quinone oxidoreductase P1 - Arabidopsis thaliana; See PMID 11004574; See PMID 3377754; uncharacterized protein 718750 4989883 An18g03210 Aspergillus niger uncharacterized protein XP_001398781.1 717497 D 5061 CDS An18g03220 4989884 complement(718919..720520) VIII 1 NT_166533.1 Catalytic activity: S-adenosyl-L-methionine + tRNA <=> S-adenosyl-L-homocysteine + tRNA containing thymine.; Remark: alternate names for S. cerevisiae Trm2: Rnc1, Nuc2 or YKR056W.; Title: strong similarity to the tRNA(m5U54)methyltransferase Trm2 - Saccharomyces cerevisiae; See PMID 10864043; uncharacterized protein 720520 4989884 An18g03220 Aspergillus niger uncharacterized protein XP_001398782.1 718919 R 5061 CDS An18g03230 4989885 join(720956..721994,722053..722348) VIII 1 NT_166533.1 Remark: literature about the mitochondrial ribosome structure: Pubmed 11279123.; Similarity: the ORF encoded protein shows strong similarity to the probable mitochondrial ribosomal S5 subunits from S. cerevisiae (MrpS5/YBR251w) and S. pombe (SPAC4G9. 17c).; Title: similarity to ribosomal protein of the small subunit S5 rpsE - Synechococcus sp.; localisation:mitochondrion; See PMID 9300823; mitochondrial 37S ribosomal protein uS5m 722348 4989885 An18g03230 Aspergillus niger mitochondrial 37S ribosomal protein uS5m XP_001398783.1 720956 D 5061 CDS An18g03240 4989886 complement(join(722688..723008,723158..723331)) VIII 1 NT_166533.1 Title: similarity to hypothetical protein CAD21178.1 - Neurospora crassa; uncharacterized protein 723331 4989886 An18g03240 Aspergillus niger uncharacterized protein XP_001398784.1 722688 R 5061 CDS An18g03250 4989887 complement(join(724137..724482,724531..724912,724966..725091,725139..725312,725368..726262)) VIII 1 NT_166533.1 Catalytic activity: ATP + a protein <=> ADP + a phosphoprotein.; Function: the protein kinase NRC-2 from N. crassa controls the entry of the cell into the asexual developmental program. it is required to repress entry into the conidiation program.; Similarity: the ORF encoded protein and N. crassa NRC-2 belong to the Kin82 subfamily of Ser/Thr protein kinases.; Title: strong similarity to protein kinase NRC-2 -Neurospora crassa; deleted EC_number 2.7.1.37; See PMID 9584090; uncharacterized protein 726262 4989887 An18g03250 Aspergillus niger uncharacterized protein XP_001398785.1 724137 R 5061 CDS An18g03260 84593690 complement(join(726794..726979,727056..727102,727400..727418)) VIII 1 NT_166533.1 hypothetical protein 727418 84593690 An18g03260 Aspergillus niger hypothetical protein XP_059605655.1 726794 R 5061 CDS An18g03270 4989889 complement(join(728270..728741,728788..728856,728911..730945,731034..731121)) VIII 1 NT_166533.1 Remark: the protein sequence described in patent CA2219958-A1 is identical to the sequence of the protein kinase Ste20 from S. cerevisiae, which is involved in regulation of pseudohyphal growth and signal transduction of mating signal.; Title: weak similarity to Ste4p/Gbeta interaction domain of Ste20p/PAK from patent CA2219958-A1 -Unclassified organism; uncharacterized protein 731121 4989889 An18g03270 Aspergillus niger uncharacterized protein XP_059605656.1 728270 R 5061 CDS An18g03280 4989890 complement(join(732211..732761,732976..733300)) VIII 1 NT_166533.1 Title: similarity to hypothetical protein B13D24.040 - Neurospora crassa; uncharacterized protein 733300 4989890 An18g03280 Aspergillus niger uncharacterized protein XP_001398788.1 732211 R 5061 CDS An18g03290 4989891 complement(join(733823..734161,734212..734549,734606..734706,734765..734909,734960..735074,735138..735629,735691..735842,735912..736017,736090..736152)) VIII 1 NT_166533.1 Function: the PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.; Remark: a splice site was detected upstream of the START codon.; Similarity: the ORF encoded protein shows strong similarity to the S. cervisiae homolog of the p65 PP2A subunit TPD3, which is known to be important for cell cycle, cytoskeleton and cell wall Pubmed 7796803.; Title: strong similarity to regulator subunit of the protein phosphatase 2A PR65 - Xenopus laevis; See PMID 7601134; See PMID 7681822; uncharacterized protein 736152 4989891 An18g03290 Aspergillus niger uncharacterized protein XP_001398789.1 733823 R 5061 CDS An18g03300 4989892 join(737129..737181,737238..737278,737341..737360,737421..737497,737554..737683,737741..738007,738064..738305,738360..739168,739226..739389) VIII 1 NT_166533.1 Catalytic activity: ATP + L-phenylalanine + tRNA(Phe) <=> AMP + diphosphate + L-phenylalanyl-tRNA(Phe).; Title: strong similarity to cytosolic phenylalanine--tRNA ligase alpha subunit Frs1 -Saccharomyces cerevisiae; cytoplasm; See PMID 3049607; uncharacterized protein 739389 4989892 An18g03300 Aspergillus niger uncharacterized protein XP_001398790.1 737129 D 5061 CDS An18g03310 4989893 complement(join(740333..740665,740888..741201,741457..741610)) VIII 1 NT_166533.1 Function: the S. cerevisiae Rps3 protein is component of the yeast cytosolic 40S ribosomal subunit.; Remark: alternate name for S. cerevisiae Rps3: Suf14, ribosomal protein S3(rp13)(S3), YNL178W.; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S3 - Saccharomyces cerevisiae; cytoplasm; See PMID 8670293; 40S ribosomal protein uS3 741610 4989893 An18g03310 Aspergillus niger 40S ribosomal protein uS3 XP_001398791.1 740333 R 5061 CDS An18g03320 4989894 complement(join(742274..742956,743095..744031,744093..744635)) VIII 1 NT_166533.1 Catalytic activity: a phosphoprotein + H(2)O <=> a protein + phosphate.; Function: human MTM1 is a dual-specificity phosphatase that acts on both phosphotyrosine and phosphoserine. It could be involved in a signal transduction pathway necessary for late myogenesis,although its ubiquitous expression suggests a wider function.; Similarity: human MTM1 belongs to the non-receptor class of the protein-tyrosine phosphatase family and to the myotubularin subfamily. The MTM gene subfamily has members in S. pombe, C. elegans, zebrafish, Drosophila, S. cerevisiae mouse and man.; Title: strong similarity to phosphatase myotubularin MTM1 - Homo sapiens; See PMID 8640223; See PMID 9736772; uncharacterized protein 744635 4989894 An18g03320 Aspergillus niger uncharacterized protein XP_059605657.1 742274 R 5061 CDS An18g03330 4989895 join(745507..745652,745739..746699) VIII 1 NT_166533.1 Function: glucanases possibly play a role in cell expansion during growth, in cell-cell fusion during mating,and in spore release during sporulation. The exo-1,3-beta-glucanase Exg1 from S. cerevisiae enzyme hydrolyzes both 1,3-beta-and 1,6-beta-linkages and even it has beta-glucosidase activity. It could also function biosynthetically as a transglycosylase.; Remark: alternate names for S. cerevisiae Exg1: Bgl1 or YLR300w.; Remark: the alignment of the ORF encoded protein to the S. cerevisiae exo-beta-1,3-glucanase (Exg1/YLR300w) is missing in the blastP-output-list.; Title: similarity to exo-1,3-beta-glucanase Exg1 -Saccharomyces cerevisiae; cell wall; See PMID 9748433; See PMID 3033651; uncharacterized protein 746699 4989895 An18g03330 Aspergillus niger uncharacterized protein XP_001398793.1 745507 D 5061 CDS An18g03335 4989896 complement(747028..749367) VIII 1 NT_166533.1 hypothetical protein 749367 4989896 An18g03335 Aspergillus niger hypothetical protein XP_059605658.1 747028 R 5061 CDS An18g03340 4989897 complement(join(749679..750258,750326..750738,750799..750822,750879..750895,750988..751000)) VIII 1 NT_166533.1 Title: strong similarity to hypothetical protein SPCC1494.08c - Schizosaccharomyces pombe; uncharacterized protein 751000 4989897 An18g03340 Aspergillus niger uncharacterized protein XP_001398795.1 749679 R 5061 CDS An18g03350 4989898 751565..751981 VIII 1 NT_166533.1 Title: weak similarity to hypothetical protein AAG17244.1 - Homo sapiens; uncharacterized protein 751981 4989898 An18g03350 Aspergillus niger uncharacterized protein XP_001398796.1 751565 D 5061 CDS An18g03360 4989899 complement(join(752639..752677,752735..755011)) VIII 1 NT_166533.1 Similarity: the similarities of the ORF encoded protein to the matching proteins are mainly based on repetitive structures.; Title: similarity to proteophosphoglycan ppg1 -Leishmania major; extracellular/secretion proteins; See PMID 10531342; uncharacterized protein 755011 4989899 An18g03360 Aspergillus niger uncharacterized protein XP_059605659.1 752639 R 5061 CDS An18g03370 84593691 join(755889..756125,756178..756327,756473..756535,756652..756924,757075..757108,757299..757348,757428..757532,757884..758030) VIII 1 NT_166533.1 hypothetical protein 758030 84593691 An18g03370 Aspergillus niger hypothetical protein XP_059605660.1 755889 D 5061 CDS An18g03380 4989901 join(759685..759707,759808..760105) VIII 1 NT_166533.1 Function: recombinant S. cerevisiae Trx3 thioredoxin is active in the insulin reduction assay.; Remark: alternate name for S. cerevisiae Trx3: YCR083W.; Title: strong similarity to mitochondrial thioredoxin Trx3 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 10037727; uncharacterized protein 760105 4989901 An18g03380 Aspergillus niger uncharacterized protein XP_001398799.1 759685 D 5061 CDS An18g03390 84593692 complement(join(761356..761522,761655..761723,761753..761781,761813..761826,761869..761991)) VIII 1 NT_166533.1 hypothetical protein 761991 84593692 An18g03390 Aspergillus niger hypothetical protein XP_059605661.1 761356 R 5061 CDS An18g03400 84593693 complement(join(762612..762788,762855..762934,763015..763388,763508..763578)) VIII 1 NT_166533.1 Title: weak similarity to hypothetical fatty acid alpha-oxidase PIOX - Oryza sativa; uncharacterized protein 763578 84593693 An18g03400 Aspergillus niger uncharacterized protein XP_059605662.1 762612 R 5061 CDS An18g03405 84593694 complement(764176..764424) VIII 1 NT_166533.1 hypothetical protein 764424 84593694 An18g03405 Aspergillus niger hypothetical protein XP_059605663.1 764176 R 5061 CDS An18g03410 84593695 join(764923..765087,765249..765464,765620..765949,766173..766374,766427..766491) VIII 1 NT_166533.1 Similarity: the ORF DNA sequence shows strong similarity to the EST an_2652 from Aspergillus niger.; Title: weak similarity to protein NUMB-R - Homo sapiens; uncharacterized protein 766491 84593695 An18g03410 Aspergillus niger uncharacterized protein XP_059605664.1 764923 D 5061 CDS An18g03420 84593696 complement(join(766696..766819,767194..767431,767516..767678,767709..767806,768369..768393,768511..768669)) VIII 1 NT_166533.1 Similarity: the similarities of the ORF encoded protein to the matching proteins are mainly based on repetitive structures.; Title: weak similarity to hypothetical protein Y51H4A.12 - Caenorhabditis elegans; uncharacterized protein 768669 84593696 An18g03420 Aspergillus niger uncharacterized protein XP_059605665.1 766696 R 5061 CDS An18g03430 4989907 join(769149..769938,769977..770377) VIII 1 NT_166533.1 Title: similarity to EST n1a10a1.r1 - Aspergillus nidulans; uncharacterized protein 770377 4989907 An18g03430 Aspergillus niger uncharacterized protein XP_059605666.1 769149 D 5061 CDS An18g03440 84593697 complement(join(770980..771126,771205..771513)) VIII 1 NT_166533.1 hypothetical protein 771513 84593697 An18g03440 Aspergillus niger hypothetical protein XP_059605667.1 770980 R 5061 CDS An18g03450 4989909 771781..773847 VIII 1 NT_166533.1 Function: protein kfrA of E. aerogenes is a repressor of transcription.; Title: weak similarity to protein kfrA -Enterobacter aerogenes plasmid R751; See PMID 9245806; uncharacterized protein 773847 4989909 An18g03450 Aspergillus niger uncharacterized protein XP_001398807.1 771781 D 5061 CDS An18g03460 4989910 complement(774181..774483) VIII 1 NT_166533.1 Title: strong similarity to hypothetical protein SPBC211.05 - Schizosaccharomyces pombe; uncharacterized protein 774483 4989910 An18g03460 Aspergillus niger uncharacterized protein XP_001398808.3 774181 R 5061 CDS An18g03470 4989911 join(774737..774905,775034..775067,775137..776418) VIII 1 NT_166533.1 Function: the S. cerevisiae the tRNA-specific adenosine deaminase Tad1 deaminates adenosine-37 to inosine in tRNA-Ala.; Remark: alternate name for S. cerevisiae Tad1: YGL243W.; Title: similarity to tRNA-specific adenosine deaminase subunit Tad1 - Saccharomyces cerevisiae; See PMID 9707437; uncharacterized protein 776418 4989911 An18g03470 Aspergillus niger uncharacterized protein XP_059605668.1 774737 D 5061 CDS An18g03480 4989912 complement(join(776506..777614,777664..777968,778021..778100)) VIII 1 NT_166533.1 Function: the erg-3 protein from N. crassa reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24- dienol.; Pathway: the erg-3 protein from N. crassa is involved in the ergosterol biosynthesis.; Title: strong similarity to sterol delta14,15-reductase erg-3 - Neurospora crassa; See PMID 10411271; uncharacterized protein 778100 4989912 An18g03480 Aspergillus niger uncharacterized protein XP_001398810.1 776506 R 5061 CDS An18g03490 4989913 join(778485..778858,778918..779205,779253..779379,779832..780017) VIII 1 NT_166533.1 Function: the bovine mannose 6-phosphate receptor CD-MPR is involved in the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.; Golgi; Remark: alternate names for the bovine mannose 6-phosphate receptor CD-MPR: CD Man-6-P Receptor, MPR 46 or M6PR.; Title: similarity to cation-dependent mannose 6-phosphate receptor precursor CD-MPR - Bos taurus; See PMID 9604938; See PMID 10601243; See PMID 7559753; uncharacterized protein 780017 4989913 An18g03490 Aspergillus niger uncharacterized protein XP_001398811.1 778485 D 5061 CDS An18g03530 84593698 complement(781628..784702) VIII 1 NT_166533.1 Function: nirA of A. nidulans is a zinc finger transcription factor mediating nitrate induction of genes involved in nitrate assimilation (nitrate reductase,nitrite reductases and a nitrate permease, niaD, niiA and crnA, respectively).; Remark: the nitrate assimilation genes are induced by nitrate and repressed by ammonium at the transcriptional level.; Similarity: the nirA protein from A. nidulans is a zinc finger transcription factor of the fungal Zn(2)-Cys(6) binuclear cluster domain type.; Title: similarity to nitrate assimilation regulatory protein nirA - Aspergillus nidulans; nucleus; See PMID 1756977; See PMID 1922075; uncharacterized protein 784702 84593698 An18g03530 Aspergillus niger uncharacterized protein XP_001398812.1 781628 R 5061 CDS An18g03540 4989917 complement(join(785506..785620,785674..785755,785817..786372)) VIII 1 NT_166533.1 Title: similarity to hypothetical protein ZK84.2 -Caenorhabditis elegans; uncharacterized protein 786372 4989917 An18g03540 Aspergillus niger uncharacterized protein XP_059605669.1 785506 R 5061 CDS An18g03550 4989919 complement(join(788409..789065,789114..789200,789248..789390,789456..789687)) VIII 1 NT_166533.1 Function: the overexpression of ACR3 induced high level arsenite resistance. S. cerevisiae acr3 disruptants are 5-fold more sensitive to arsenate and arsenite than wild-type cells.; Remark: alternate names for S. cerevisiae Acr3: YPR201w or Aar3.; Similarity: the ORF encoded protein also shows strong similarity the Sequence 119 from Patent WO0100804 (Corynebacterium glutamicum), but its function is not clearly enough decribed.; Title: strong similarity to membrane protein involved in arsenite transport Acr3 - Saccharomyces cerevisiae; See PMID 9374482; See PMID 10354596; uncharacterized protein 789687 4989919 An18g03550 Aspergillus niger uncharacterized protein XP_001398814.1 788409 R 5061 CDS An18g03560 84593699 join(790195..790243,790323..790354,790453..790472,790724..791003,791088..791130,791254..791511,791728..791909,792003..792062,792147..792233,792351..792454,792531..792690) VIII 1 NT_166533.1 Title: weak similarity to human protein MLN 51 from patent WO9706256-A2 - Homo sapiens; uncharacterized protein 792690 84593699 An18g03560 Aspergillus niger uncharacterized protein XP_059605670.1 790195 D 5061 CDS An18g03570 4989921 join(793928..793984,794081..794223,794275..794319,794374..794426,794478..795669,795732..796590,796642..796875) VIII 1 NT_166533.1 Function: hydrolyzes beta-glycosidic bond and hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose.; Gene-ID: bgl1; Pathway: involved in cyanoamino acid metabolism; starch and sucrose metabolism and flavonoids, stilbene and lignin biosynthesis.; Remark: an additional blastx reveals that the intergenic region between this ORF and the downstream ORF codes for 3' untranslated region (see trembl:ANI132386).; Similarity: 92-kDa enzyme that is a member of glycosidase family 3.; See PMID 10671536; beta-glucosidase bgl1-Aspergillus niger 796875 bgl1 4989921 bgl1 Aspergillus niger beta-glucosidase bgl1-Aspergillus niger XP_001398816.1 793928 D 5061 CDS An18g03580 4989922 join(797241..797964,798139..798266) VIII 1 NT_166533.1 Remark: an additional blastx search reveals that the intergenic region between this ORF and the upstream ORF codes for 3' untranslated region (see trembl:ANI132386).; Remark: this might be a questionable ORF because gene prediction of 3'exons is difficult.; Similarity: 5'-region shows strong similarity to 3'UTR of beta-glucosidase from A. niger until pos 4497.; Similarity: predicted protein shows weak similarity to inositol phospholipid synthesis protein SCS3 of S. cerevisiae (see MIPS YGL126w).; Similarity: the ORF shows strong similarity to EST of exons 1-7 of beta-glucosidase bgl1 - Aspergillus niger.; Title: similarity to hypothetical protein SPBC543.08 - Schizosaccharomyces pombe; See PMID 10671536; uncharacterized protein 798266 4989922 An18g03580 Aspergillus niger uncharacterized protein XP_059605671.1 797241 D 5061 CDS An18g03590 4989923 complement(join(798391..798677,798762..799611)) VIII 1 NT_166533.1 Similarity: shows only partial similarity to C. elegans protein.; Title: weak similarity to hypothetical protein W09B7.d - Caenorhabditis elegans; uncharacterized protein 799611 4989923 An18g03590 Aspergillus niger uncharacterized protein XP_001398818.3 798391 R 5061 CDS An18g03600 4989924 join(<799815..799856,800016..801383) VIII 1 NT_166533.1 Function: ereB from E. coli inactivates erythromycin and oleandomycin.; Function: the enzyme of E. coli confers resistance to erythromycin through inactivation by hydrolyzing the lactone ring of the antibiotic.; Remark: truncated ORF due to contig border.; Title: similarity to erythromycin esterase type II ereB - Escherichia coli [truncated ORF]; See PMID 3523438; See PMID 3541783; uncharacterized protein 801383 4989924 An18g03600 Aspergillus niger uncharacterized protein XP_001398819.3 799815 D 5061 CDS An18g03610 4989925 join(801671..801718,801807..804083) VIII 1 NT_166533.1 Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive stretches in the sequence.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 9987114; See PMID 11152942; See PMID 8710886; See PMID 9383611; uncharacterized protein 804083 4989925 An18g03610 Aspergillus niger uncharacterized protein XP_059602906.1 801671 D 5061 CDS An18g03620 4989926 join(805047..805245,805624..807476) VIII 1 NT_166533.1 Similarity: shows only partial similarity to N. crassa protein.; Title: weak similarity to mediator of mating-type associated vegetative incompatibility tol - Neurospora crassa; uncharacterized protein 807476 4989926 An18g03620 Aspergillus niger uncharacterized protein XP_059602907.1 805047 D 5061 CDS An18g03630 4989927 complement(809051..810310) VIII 1 NT_166533.1 Similarity: shows weak similarity to GntP family permeases, a family of integral membrane permeases that are involved in gluconate uptake.; Title: similarity to hypothetical protein encoded by An07g02000 - Aspergillus niger; uncharacterized protein 810310 4989927 An18g03630 Aspergillus niger uncharacterized protein XP_059602908.1 809051 R 5061 CDS An18g03640 4989928 complement(join(811495..811835,811871..811901)) VIII 1 NT_166533.1 Similarity: shows similarity to aminoterminal part of viral proteins, putatively belongs to transposable elements, viral and plasmid proteins in the funcat.; Title: weak similarity to polymerase-associated nucleocapsid phosphoprotein - Parainfluenza virus type 1; uncharacterized protein 811901 4989928 An18g03640 Aspergillus niger uncharacterized protein XP_059602909.1 811495 R 5061 CDS An18g03650 84593700 complement(join(813895..813957,814009..814036,814283..814395)) VIII 1 NT_166533.1 Remark: this region might be destroyed by a transposable element because it only shows parts of similarities.; Similarity: shows similarity to different proteins of various species, but is much shorter.; Title: weak similarity to hypothetical protein CG6066 - Drosophila melanogaster; uncharacterized protein 814395 84593700 An18g03650 Aspergillus niger uncharacterized protein XP_059602910.1 813895 R 5061 CDS An18g03660 4989930 complement(join(814788..816797,816844..816941,816988..817870)) VIII 1 NT_166533.1 Function: Prk1 protein kinase of S. cerevisiae regulates the actin cytoskeleton organization by modulating the activities of some actin cytoskeleton-related proteins such as Pan1p/End3p.; Similarity: shows higher similarity to probable serine threonine-protein kinase of S. pombe.; Title: similarity to ser/thr protein kinase Prk1 -Saccharomyces cerevisiae; cytoplasm; See PMID 9885245; See PMID 10087264; uncharacterized protein 817870 4989930 An18g03660 Aspergillus niger uncharacterized protein XP_001398825.1 814788 R 5061 CDS An18g03670 4989931 join(819703..820376,820415..821743,821972..822059) VIII 1 NT_166533.1 Function: Caldesmon is a smooth muscle and nonmuscle regulatory protein that interacts with actin, myosin,tropomyosin, and calmodulin.; Similarity: blast hits and predicted protein contain long stretches of repetitive sequences and similarity is restricted to these sequences.; Title: similarity to calmodulin- and actin-binding protein h-caldesmon - Gallus gallus; See PMID 2760048; uncharacterized protein 822059 4989931 An18g03670 Aspergillus niger uncharacterized protein XP_059602911.1 819703 D 5061 CDS An18g03680 84593701 join(822363..822483,822516..822631) VIII 1 NT_166533.1 hypothetical protein 822631 84593701 An18g03680 Aspergillus niger hypothetical protein XP_059602912.1 822363 D 5061 CDS An18g03690 4989933 join(822980..823431,823496..823809,823859..823986) VIII 1 NT_166533.1 Similarity: shows only similarity at the aminoterminus.; Similarity: shows weak similarity to a keratin domain that is common in avian keratin proteins, found in feathers, scale and claw.; Title: weak similarity to integral membrane protein PTH11 - Magnaporthe grisea; See PMID 10521529; uncharacterized protein 823986 4989933 An18g03690 Aspergillus niger uncharacterized protein XP_001398828.3 822980 D 5061 CDS An18g03700 4989934 complement(join(824153..824402,824455..825616,825676..825877)) VIII 1 NT_166533.1 Function: P58, expressed as a histidine fusion protein in Escherichia coli, blocked both the autophosphorylation of PKR and phosphorylation of the alpha subunit of eIF-2.; Similarity: PKR inhibitor is a member of the tetratricopeptide repeat family of proteins, the only member identified thus far with a known biochemical function.; Similarity: predicted protein shows higher similarity to other TPR and DNAJ domain containing proteins and is clearly a member of this family.; Title: similarity to inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) p58 - Bos primigenius taurus; uncharacterized protein 825877 4989934 An18g03700 Aspergillus niger uncharacterized protein XP_001398829.3 824153 R 5061 CDS An18g03710 4989935 complement(join(827453..827775,827829..828205,828257..828282,828323..828453,828485..828560,828607..828760,828932..830753,830805..831008,831073..831202)) VIII 1 NT_166533.1 Function: the conventional myosin motor proteins that drive mammalian skeletal and cardiac muscle contraction include eight sarcomeric myosin heavy chain (MyHC) isoforms.; Similarity: shows partial similarity to myosin heavy chain of several species.; Title: similarity to secreted polypeptide #102 from patent WO2003025142-A2 - Homo sapiens; uncharacterized protein 831202 4989935 An18g03710 Aspergillus niger uncharacterized protein XP_059602913.1 827453 R 5061 CDS An18g03720 4989936 complement(832012..832836) VIII 1 NT_166533.1 Similarity: blast hits result from repetitive sequences.; hypothetical protein 832836 4989936 An18g03720 Aspergillus niger hypothetical protein XP_001398831.1 832012 R 5061 CDS An18g03730 4989937 complement(join(834855..834960,835019..835605)) VIII 1 NT_166533.1 Similarity: blast hits mainly result from repetitive sequences.; Title: weak similarity to hypothetical protein CG2779 - Drosophila melanogaster; uncharacterized protein 835605 4989937 An18g03730 Aspergillus niger uncharacterized protein XP_001398832.1 834855 R 5061 CDS An18g03740 4989938 join(841957..842694,842753..843044,843100..843469,843522..843621,843652..843780) VIII 1 NT_166533.1 Function: MKK2 is involved in a signal transduction pathway that plays a role in yeast cell morphogenesis and cell growth.; Title: strong similarity to protein kinase of the MAP kinase kinase 2 Mkk2 - Saccharomyces cerevisiae; See PMID 9443897; See PMID 9618441; uncharacterized protein 843780 4989938 An18g03740 Aspergillus niger uncharacterized protein XP_059602914.1 841957 D 5061 CDS An18g03750 84593702 complement(845257..>846051) VIII 1 NT_166533.1 Remark: truncated ORF due to contig border.; Title: similarity to hypothetical protein 15E6.130 -Neurospora crassa [truncated ORF]; uncharacterized protein 846051 84593702 An18g03750 Aspergillus niger uncharacterized protein XP_059602915.1 845257 R 5061 CDS An18g03760 4989940 complement(join(<846156..846403,846458..846611,846661..848331,848418..848456,848832..>848928)) VIII 1 NT_166533.1 Similarity: the ORF DNA sequence shows also similarity to the A. niger EST an_1616.; Title: strong similarity to hypothetical protein 15E6.130 - Neurospora crassa; uncharacterized protein 848928 4989940 An18g03760 Aspergillus niger uncharacterized protein XP_059606578.1 846156 R 5061 CDS An18g03770 4989941 join(851260..851270,851341..851358,851425..856788,856843..857137) VIII 1 NT_166533.1 Function: the Mot1 protein from S. cerevisiae regulates transcription in association with the TATA binding protein (TBP). It removes TBP from the TATA box in a ATP-dependent manner.; Remark: alternate names for S. cerevisiae Mot1: Bur3, Lpf4 or YPL082C.; Similarity: Mot1 belongs to the Snf2/Rad54 helicase family.; Title: strong similarity to ATPase Mot1 -Saccharomyces cerevisiae; nucleus; See PMID 10887203; uncharacterized protein 857137 4989941 An18g03770 Aspergillus niger uncharacterized protein XP_001398836.1 851260 D 5061 CDS An18g03780 4989942 complement(858016..860976) VIII 1 NT_166533.1 Similarity: the ORF encoded protein is also similar to 24 kDa vacuolar protein VP24 of unknown function from Ipomoea batatas (sweet potato), which may be involved in vacuolar transport and/or accumulation of anthocyanin synthesized in the cytosol (Pubmed 11154352;9390439; 11164584).; Title: strong similarity to hypothetical protein 9G6.250 - Neurospora crassa; uncharacterized protein 860976 4989942 An18g03780 Aspergillus niger uncharacterized protein XP_001398837.1 858016 R 5061 CDS An18g03790 4989943 complement(join(861636..861995,862053..862739,862802..863533)) VIII 1 NT_166533.1 Function: the S. cerevisiae Grr1 protein is involved in the ubiquitin-dependent degradation of regulatory proteins. This system needs the Skp1p-cullin-F-box protein (SCF) complex.; Remark: alternate names for S. cerevisiae Grr1: Cat80, Cot2, Ssu2 or YJR090C.; Remark: in comparison to the ORF encoded protein the S. cerevisiae Grr1 protein is N-terminally and C-terminally extended.; Title: similarity to protein involved in SCF dependent protein degradation Grr1 - Saccharomyces cerevisiae; See PMID 9891035; See PMID 11259599; uncharacterized protein 863533 4989943 An18g03790 Aspergillus niger uncharacterized protein XP_059606579.1 861636 R 5061 CDS An18g03800 4989944 complement(join(865086..865390,865460..866089,866146..866592,866675..866870,866950..867141)) VIII 1 NT_166533.1 Catalytic activity: ATP + a long-chain carboxylic acid + CoA <=> AMP + diphosphate + an acyl-CoA.; Pathway: the alkBFGHJKL and alkST operons encode enzymes that allow Pseudomonas putida to metabolize alkanes.; Remark: a splice site was detected upstream of the START codon.; Remark: the alkK gene from Pseudomonas putida complements a fadD (acyl-CoA synthetase) mutation in Escherichia coli.; Title: strong similarity to acyl-CoA synthase AlkK -Pseudomonas putida; See PMID 1453953; uncharacterized protein 867141 4989944 An18g03800 Aspergillus niger uncharacterized protein XP_001398839.1 865086 R 5061 CDS An18g03810 4989945 complement(join(868936..869074,869167..869425,869511..869564,869753..869888,870042..870062)) VIII 1 NT_166533.1 Remark: alternate names for S. cerevisiae 60S ribosomal protein L13A: RPL13A, RP22, RPL16A or YIL133C.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit L13a - Saccharomyces cerevisiae; cytoplasm; See PMID 3282992; 60S ribosomal protein uL13 870062 4989945 An18g03810 Aspergillus niger 60S ribosomal protein uL13 XP_001398840.1 868936 R 5061 CDS An18g03820 4989946 complement(<871030..872896) VIII 1 NT_166533.1 Catalytic activity: palmitoyl-CoA + L-serine <=> CoA + 3-dehydro-D-sphinganine + CO(2).; Cofactor: Pyridoxal-phosphate.; Function: the S. cerevisiae Lcb2 protein catalyzes the first step in the biosynthesis of the long-chain base component of sphingolipids.; Pathway: Lcb2 is involved in the sphingolipid biosynthesis.; Remark: ORF contains a frameshift, due to a putative sequencing error.; Remark: alternate names for S. cerevisiae Lcb2: Scs1, Tsc1 or YDR062W.; Title: strong similarity to serine C-palmitoyltransferase Lcb2 - Saccharomyces cerevisiae [putative frameshift]; putative frameshift; See PMID 1556076; See PMID 8058731; See PMID 8063782; uncharacterized protein 872896 4989946 An18g03820 Aspergillus niger uncharacterized protein XP_059606580.1 871030 R 5061 CDS An18g03830 4989947 join(873597..873798,873942..874876) VIII 1 NT_166533.1 Title: strong similarity to hypothetical protein 9G6.100 - Neurospora crassa; uncharacterized protein 874876 4989947 An18g03830 Aspergillus niger uncharacterized protein XP_001398842.1 873597 D 5061 CDS An18g03850 84593703 complement(join(876599..876673,876792..876968,877047..877102,877217..877447,877509..877618,877695..877868,877912..877964)) VIII 1 NT_166533.1 hypothetical protein 877964 84593703 An18g03850 Aspergillus niger hypothetical protein XP_059606581.1 876599 R 5061 CDS An18g03860 84593704 complement(join(878659..878682,878776..878806,879220..879488)) VIII 1 NT_166533.1 hypothetical protein 879488 84593704 An18g03860 Aspergillus niger hypothetical protein XP_059606582.1 878659 R 5061 CDS An18g03870 4989951 join(881215..881481,881594..882940) VIII 1 NT_166533.1 Similarity: the similarity of the ORF encoded protein to the human protein of the DnaJ/Hsp40 family MRJ is limited to N-terminal DnaJ domain.; Title: similarity to DnaJ/Hsp40 family protein MRJ -Homo sapiens; See PMID 10954706; uncharacterized protein 882940 4989951 An18g03870 Aspergillus niger uncharacterized protein XP_059606583.1 881215 D 5061 CDS An18g03880 4989952 complement(join(883858..883941,884000..884025,884177..885128)) VIII 1 NT_166533.1 Function: the SalE enzyme from Acinetobacter sp. strain ADP1 was shown to have esterase activity against short-chain alkyl esters of 4-nitrophenol but was also able to hydrolyze ethyl salicylate to ethanol and salicylic acid.; Remark: a salE mutant had lost the ability to utilize only ethyl and methyl salicylates as sole carbon sources.; Title: similarity to alkyl salicylate esterase salE - Acinetobacter sp.; See PMID 10715011; uncharacterized protein 885128 4989952 An18g03880 Aspergillus niger uncharacterized protein XP_001398846.3 883858 R 5061 CDS An18g03890 4989953 complement(join(885776..886263,886312..886614,886669..887608)) VIII 1 NT_166533.1 Title: weak similarity to transcription regulator alcR - Aspergillus nidulans; uncharacterized protein 887608 4989953 An18g03890 Aspergillus niger uncharacterized protein XP_001398847.3 885776 R 5061 CDS An18g03900 4989954 complement(join(888196..888652,888755..888845,888912..888951)) VIII 1 NT_166533.1 Complex: the prefoldin subunit 2 PFDN2 is organized in a heterohexamer of two PFD-alpha type and four PFD-beta type subunits.; Function: the human prefoldin subunit 2 PFDN2 binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. It binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.; Similarity: the human PFDN2 protein belongs to the prefoldin beta subunit family.; Title: strong similarity to prefoldin subunit 2 PFDN2 - Homo sapiens; cytoplasm; See PMID 9630229; uncharacterized protein 888951 4989954 An18g03900 Aspergillus niger uncharacterized protein XP_059606584.1 888196 R 5061 CDS An18g03910 4989955 join(889401..891788,891844..892200) VIII 1 NT_166533.1 Function: hPrp16 is a ATP-dependent RNA helicase involved in pre-mRNA splicing.; Title: strong similarity to pre-mRNA splicing factor and ATP-dependent RNA helicase hPrp16 - Homo sapiens; nucleus; See PMID 9524131; See PMID 9769096; uncharacterized protein 892200 4989955 An18g03910 Aspergillus niger uncharacterized protein XP_001398849.1 889401 D 5061 CDS An18g03920 4989956 complement(join(892532..892598,892667..892684,892763..892857,892951..893166)) VIII 1 NT_166533.1 Function: the mammalian DAD1 protein was identified as a cell death supressor that may act downstream of the bcl-2 protein.; Title: strong similarity to defender against apoptotic cell death DAD1 - Homo sapiens; See PMID 8413235; See PMID 9144178; uncharacterized protein 893166 4989956 An18g03920 Aspergillus niger uncharacterized protein XP_059606585.1 892532 R 5061 CDS An18g03930 84593705 complement(join(893776..895617,895679..896287)) VIII 1 NT_166533.1 Similarity: the transcription factor CTFalpha from Fusarium solani belongs to the fungal Cys6Zn2 binucle cluster family.; Title: similarity to cutinase transcription factor 1 CTF1-alpha - Fusarium solani; See PMID 9139694; uncharacterized protein 896287 84593705 An18g03930 Aspergillus niger uncharacterized protein XP_059606586.1 893776 R 5061 CDS An18g03940 4989957 complement(join(897252..897305,897811..897835,897888..898015,898067..898381,898438..898574,898635..898658,898725..898941)) VIII 1 NT_166533.1 Function: the Mnn4 protein from S. cerevisiae may function as a positive regulator for mannosylphosphate transferase. It is required to mediate mannosylphosphate transfer in both the core and outer chain portions of N-linked oligosaccharides.; Remark: the ORF encoded protein is much shorter (299aa) than S. cerevisae Mnn4 (1178aa).; Remark: the S. cerevisiae Mnn4 protein is also described in patent JP09266792-A.; Title: similarity to mannosylphosphorylation protein Mnn4 - Saccharomyces cerevisiae; uncharacterized protein 898941 4989957 An18g03940 Aspergillus niger uncharacterized protein XP_059606587.1 897252 R 5061 CDS An18g03950 4989959 join(902864..903495,903546..903823,903883..904811) VIII 1 NT_166533.1 Remark: the cercosporin toxin resistance protein CRG1 from C. nicotianae is also described patent WO9841082-A1.; Title: strong similarity to cercosporin toxin resistance protein CRG1 - Cercospora nicotianae; See PMID 10517336; uncharacterized protein 904811 4989959 An18g03950 Aspergillus niger uncharacterized protein XP_001398853.3 902864 D 5061 CDS An18g03960 4989960 join(907135..909339,909397..910698) VIII 1 NT_166533.1 Title: strong similarity to hypothetical protein YFL034w - Saccharomyces cerevisiae; uncharacterized protein 910698 4989960 An18g03960 Aspergillus niger uncharacterized protein XP_001398854.1 907135 D 5061 CDS An18g03970 4989961 join(911690..912897,912944..913004) VIII 1 NT_166533.1 Remark: the S. cerevisiae SRP40 and the ORF encoded protein are highly repetitive.; Title: similarity to suppressor protein Srp40 -Saccharomyces cerevisiae; See PMID 8702624; See PMID 9364927; See PMID 8083243; uncharacterized protein 913004 4989961 An18g03970 Aspergillus niger uncharacterized protein XP_059606588.1 911690 D 5061 CDS An18g03980 4989962 join(913831..914695,914750..916125,916184..916240) VIII 1 NT_166533.1 Function: the NAALADase from R. norvegicus hydrolyzes acidic peptides, such as the abundant neuropeptide N-acetyl-alpha-L-aspartyl-L-glutamate (NAAG),thereby generating glutamate.; Remark: alternate names for the glutamate carboxypeptidase II from R. norvegicus: NAAG peptidase or N-acetylated alpha-linked acidic dipeptidase (NAALADase).; Similarity: the ORF encoded protein shows also strong similarity to patent WO9735616-A1 (Prostate-specific membrane antigen), the human homologue of the Rat carboxypeptidase II.; Title: strong similarity to glutamate carboxypeptidase II - Rattus norvegicus; See PMID 9375657; See PMID 9501243; uncharacterized protein 916240 4989962 An18g03980 Aspergillus niger uncharacterized protein XP_001398856.3 913831 D 5061 CDS An18g03990 4989963 join(917144..917611,917720..918089,918191..918723) VIII 1 NT_166533.1 Remark: the effect of fluoroquinolone drugs (e. g. norfloxacin) is directed to the DNA gyrase (topoisomerase IV).; Title: similarity to fluoroquinolone resistance factor NorA - Staphylococcus aureus; See PMID 10553699; See PMID 2174864; uncharacterized protein 918723 4989963 An18g03990 Aspergillus niger uncharacterized protein XP_059606589.1 917144 D 5061 CDS An18g04000 4989964 join(919123..919125,919201..919512) VIII 1 NT_166533.1 Title: similarity to hypothetical transmembrane protein SPAP14E8.05c - Schizosaccharomyces pombe; uncharacterized protein 919512 4989964 An18g04000 Aspergillus niger uncharacterized protein XP_001398858.1 919123 D 5061 CDS An18g04010 4989965 complement(join(920048..920779,920830..921206,921252..921414)) VIII 1 NT_166533.1 Function: Zep from M. musculus acts as a transcription regulation factor.; Localization: Zep from M. musculus is located in the nucleus.; Title: strong similarity to zinc-finger protein Zep - Mus musculus; nucleus; See PMID 9832628; uncharacterized protein 921414 4989965 An18g04010 Aspergillus niger uncharacterized protein XP_001398859.1 920048 R 5061 CDS An18g04020 4989966 complement(<923284..923914) VIII 1 NT_166533.1 Remark: C-terminal truncated ORF due to the end of contig.; Remark: the A-band associated protein from Drosophila melanogaster is identical to zetalin a Z-band-associated protein from Drosophila melanogaster.; Similarity: the similarity of the ORF encoded protein to all hits is based on repetitive structures.; Title: similarity to A-band associated protein -Drosophila melanogaster [truncated ORF]; uncharacterized protein 923914 4989966 An18g04020 Aspergillus niger uncharacterized protein XP_001398860.3 923284 R 5061 CDS An18g04030 4989967 join(927649..928210,928271..929253) VIII 1 NT_166533.1 Remark: Filobasidiella neoformans=Cryptococcus neoformans.; Remark: the Topoisomerase I (Topo I) from Filobasidiella neoformans is essential.; Similarity: the ORF encoded protein shows really strong similarity to the hypothetical protein SPCC1322. 09 from Schizosaccharomyces pombe.; Title: similarity to Topoisomerase I TopoI -Filobasidiella neoformans; See PMID 10224251; uncharacterized protein 929253 4989967 An18g04030 Aspergillus niger uncharacterized protein XP_001398861.1 927649 D 5061 CDS An18g04040 4989968 complement(join(929884..929953,930029..930921,931141..931152)) VIII 1 NT_166533.1 Similarity: the ORF encoded protein shows also similarity to the stationary-phase survival protein surE from Escherichia coli, thus it could be involved in stess response (adaption to stationary-phase; Pubmed 7928962; 9785447).; Title: similarity to alkaline phosphatase from patent WO9748416-A1 - Methanococcus igneus; uncharacterized protein 931152 4989968 An18g04040 Aspergillus niger uncharacterized protein XP_001398862.1 929884 R 5061 CDS An18g04050 84593706 complement(join(933067..933256,933294..933400)) VIII 1 NT_166533.1 hypothetical protein 933400 84593706 An18g04050 Aspergillus niger hypothetical protein XP_059602916.1 933067 R 5061 CDS An18g04060 4989970 join(934163..934422,934489..935644,935696..935804,935860..936185,936237..936845) VIII 1 NT_166533.1 Similarity: the similarities of the ORF encoded protein to other proteins are mainly based on repetitive structures.; Title: similarity to gastric mucin - Sus scrofa; See PMID 7755593; uncharacterized protein 936845 4989970 An18g04060 Aspergillus niger uncharacterized protein XP_059602917.1 934163 D 5061 CDS An18g04070 4989971 complement(938393..939142) VIII 1 NT_166533.1 Function: Balu-42 is differentially expressed in the pellet morphology relative to the filamentous morphology.; Gene-ID: Balu-42; differential expressed Balu-42 from patent US2003215950-A1-Aspergillus niger 939142 Balu-42 4989971 Balu-42 Aspergillus niger differential expressed Balu-42 from patent US2003215950-A1-Aspergillus niger XP_001398865.1 938393 R 5061 CDS An18g04080 4989972 complement(join(942053..942197,942276..942718,942776..943169,943249..943715)) VIII 1 NT_166533.1 Remark: vanillin-dehydrogenase VDH sequence 27 protein is part of the patent EP0845532 with the title: 'Enzymes for the synthesis of coniferyl alcohol, coniferyl aldehyde, ferulic acid, vanillin, vanillic acid and their applications'.; Title: strong similarity to vanillin-dehydrogenase VDH sequence 27 from patent EP0845532 - Unclassified organism; uncharacterized protein 943715 4989972 An18g04080 Aspergillus niger uncharacterized protein XP_001398866.1 942053 R 5061 CDS An18g04090 4989973 complement(join(945252..945690,945756..946026,946083..946197)) VIII 1 NT_166533.1 Title: strong similarity to hypothetical protein encoded by An01g14640 - Aspergillus niger; uncharacterized protein 946197 4989973 An18g04090 Aspergillus niger uncharacterized protein XP_001398867.1 945252 R 5061 CDS An18g04100 4989974 join(951530..951606,951671..952065,952122..952900) VIII 1 NT_166533.1 Similarity: the ORF encoded protein shows strong similarity to the aspergillus oryzae beta-glucosidase gene from patent WO9955884.; Similarity: the gp43 product from P. brasiliensis amino acid sequence showed similarities of 56-58% with exo-1,3- beta-D-glucanases from S. cerevisiae and Candida albicans (EC 3. 2. 1. 58), but however it is devoid of hydrolase activity; Title: strong similarity to 43 kDa secreted glycoprotein precursor gp43 - Paracoccidioides brasiliensis; extracellular/secretion proteins; See PMID 8580684; See PMID 8626811; uncharacterized protein 952900 4989974 An18g04100 Aspergillus niger uncharacterized protein XP_001398868.1 951530 D 5061 CDS An18g04110 4989975 complement(join(953307..954374,954433..954621,954672..955144,955199..956214,956270..956407,956474..956574,956643..956807)) VIII 1 NT_166533.1 Remark: Ran GTPase is required for nucleocytoplasmic transport of many types of cargo.; Similarity: it belongs to the RanBP7/importin-beta/Cse1p superfamily; Similarity: the ORF encoded protein shows also strong similarities to many Ranbp11 homologues.; Similarity: the Ranbp11 from human and its homologues are nuclear transport factors, members of karyopherin-beta family.; Title: strong similarity to nuclear transport factor Kap120 - Saccharomyces cerevisiae; See PMID 10684247; uncharacterized protein 956807 4989975 An18g04110 Aspergillus niger uncharacterized protein XP_001398869.1 953307 R 5061 CDS An18g04120 4989976 join(957521..957617,957684..957822,957894..958026) VIII 1 NT_166533.1 hypothetical protein 958026 4989976 An18g04120 Aspergillus niger hypothetical protein XP_001398870.1 957521 D 5061 CDS An18g04130 4989977 join(958491..958547,958605..958674,958755..959188,959251..960138) VIII 1 NT_166533.1 Catalytic activity: an aldehyde + NAD(+) + H(2)O <=> an acid + NADH.; Function: the indole-3-acetaldehyde dehydrogenase Iad1 from Ustilago maydis ois involved in the production of the phyto-hormon IndCH2COOH.; Remark: Ustilago maydis is a phytopathogenic fungus.; Similarity: the ORF encoded protein shows also strong similarity to the protein described in patent WO9506121-A from Cladosporium herbarum.; Title: strong similarity to indole-3-acetaldehyde dehydrogenase Iad1 - Ustilago maydis; See PMID 9022693; uncharacterized protein 960138 4989977 An18g04130 Aspergillus niger uncharacterized protein XP_001398871.1 958491 D 5061 CDS An18g04140 4989978 complement(join(960509..961607,961670..961731,961800..961985)) VIII 1 NT_166533.1 Catalytic activity: an orthophosphoric monoester + H(2)O <=> an alcohol + phosphate.; Induction: the expression of this phoA gene from P. chrysogenum is regulated at the transcriptional level and is markedly affected by the inorganic phosphate concentration of the growth medium.; Similarity: the ORF encoded protein shows also strong similarity to the protein described in patent JP02234681-A.; Title: strong similarity to extracellular acid phosphatase PhoA - Penicillium chrysogenum; extracellular/secretion proteins; See PMID 1563629; See PMID 1909579; uncharacterized protein 961985 4989978 An18g04140 Aspergillus niger uncharacterized protein XP_001398872.1 960509 R 5061 CDS An18g04150 4989979 join(963771..964079,964148..964411,964462..965334) VIII 1 NT_166533.1 Function: the car1 gene of the filamentous fungus Podospora anserina was cloned by complementation of a mutant defective for caryogamy (nuclear fusion), a process required for sexual sporulation.; Title: strong similarity to protein car1 - Podospora anserina; peroxisome; See PMID 7600573; uncharacterized protein 965334 4989979 An18g04150 Aspergillus niger uncharacterized protein XP_059602918.1 963771 D 5061 CDS An18g04160 4989980 join(965966..966124,966201..966414,966466..967919) VIII 1 NT_166533.1 Catalytic activity: 2,3-dihydroxy-3-methylbutanoate <=> 3-methyl-2-oxobutanoate + H(2)O.; Pathway: the S. cerevisae ILV3 gene product is involved in the valine, leucine and isoleucine biosynthesis and pantothenate and CoA biosynthesis.; Remark: alternate name for S. cerevisiae Ilv3: YJR016C.; Title: strong similarity to dihydroxy-acid dehydratase Ilv3 - Saccharomyces cerevisiae; See PMID 8299945; uncharacterized protein 967919 4989980 An18g04160 Aspergillus niger uncharacterized protein XP_001398874.1 965966 D 5061 CDS An18g04170 4989981 join(969575..969803,969851..971622) VIII 1 NT_166533.1 Catalytic activity: 5'-phosphopolynucleotide + H(2)O = polynucleotide + orthophosphate (reaction only describes the catalytic activity of matching part of the mouse mRNA capping enzym).; Remark: mammalian capping enzymes are bifunctional proteins with both RNA 5'-triphosphatase and guanylyltransferase activities.; Similarity: the ORF encoded protein shows distinct similarities to two different protein typs. the N-terminus of the ORF matches to hypothetical proteins from S. pombe (e. g. SPAC57A10. 08c). the C-terminus shows similarities to the tyrosine phosphatase domains from some mRNA capping enzyms.; Title: similarity to mRNA capping enzyme MCE - Mus musculus; See PMID 9770468; uncharacterized protein 971622 4989981 An18g04170 Aspergillus niger uncharacterized protein XP_001398875.3 969575 D 5061 CDS An18g04180 4989982 join(972169..972198,972730..972793,972859..972919,973000..973288) VIII 1 NT_166533.1 Remark: alternate names for S. cerevisiae S19 ribosomal protein: 40S ribosomal protein: S16A,YS16,RP55 or YP45. And for the correspondent yeast gene: RP55A,RPS16A or YOL121C.; Similarity: the ORF encoded protein shows the strongest similarity to the S19 ribosomal protein from Emericella nidulans.; Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S19 - Saccharomyces cerevisiae; cytoplasm; See PMID 6387623; See PMID 6814480; 40S ribosomal protein eS19 973288 4989982 An18g04180 Aspergillus niger 40S ribosomal protein eS19 XP_001398876.1 972169 D 5061 CDS An18g04190 4989983 complement(join(973957..973986,974098..974330,974456..974639)) VIII 1 NT_166533.1 Title: strong similarity to hypothetical protein EAA58949.1 - Aspergillus nidulans; uncharacterized protein 974639 4989983 An18g04190 Aspergillus niger uncharacterized protein XP_001398877.1 973957 R 5061 CDS An18g04200 4989984 complement(join(975101..975643,975694..976194,976248..976546,976597..977293)) VIII 1 NT_166533.1 Function: the formyl-CoA transferase frc from Oxalobacter formigenes catalyzes the transfer of CoA from formyl-CoA to either oxalate or succinate.; Pathway: in Oxalobacter formigenes oxalic acid, a highly toxic by-product of metabolism, is catabolized by utilizing an activation-decarboxylation reaction which yields formate and CO2. The formyl-CoA transferase frc is involved at this detoxification step.; Title: similarity to formyl-CoA transferase frc -Oxalobacter formigenes; See PMID 9150242; See PMID 2361939; uncharacterized protein 977293 4989984 An18g04200 Aspergillus niger uncharacterized protein XP_001398878.3 975101 R 5061 CDS An18g04210 4989985 982150..983298 VIII 1 NT_166533.1 Complex: the Stb3 protein binds to the pleiotropic S. cerevisiae transcriptional repressor Sin3.; Title: similarity to SIN3 protein-binding protein Stb3 - Saccharomyces cerevisiae; nucleus; See PMID 9393435; See PMID 11028908; uncharacterized protein 983298 4989985 An18g04210 Aspergillus niger uncharacterized protein XP_001398879.1 982150 D 5061 CDS An18g04220 4989986 complement(join(984632..985195,985253..985498,985689..985765,985889..985910,986106..986156)) VIII 1 NT_166533.1 Function: the mitochondrial ADP/ATP carrier ANC1 from Schizosaccharomyces pombe catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.; Title: strong similarity to mitochondrial ADP/ATP carrier anc1p - Schizosaccharomyces pombe; localisation:mitochondrion; See PMID 8675018; uncharacterized protein 986156 4989986 An18g04220 Aspergillus niger uncharacterized protein XP_001398880.1 984632 R 5061 CDS An18g04230 4989987 complement(join(988576..990233,990295..990466)) VIII 1 NT_166533.1 Complex: the S. cerevisiae Kri1 protein was found to be in a complex with Krr1.; Function: both proteins S. cervisiae Kri1 and Krr1 are required for 40S ribosome biogenesis in the nucleolus.; Remark: Kri1='Krr1 interacting protein'.; Remark: alternate name for S. cerevisiae Kri1: YNL308C.; Title: strong similarity to protein involved in ribosome biogenesis Kri1 - Saccharomyces cerevisiae; nucleus; See PMID 11027267; uncharacterized protein 990466 4989987 An18g04230 Aspergillus niger uncharacterized protein XP_001398881.1 988576 R 5061 CDS An18g04240 4989988 join(990902..990957,991028..991391,991448..993920,993969..994055,994108..994329,994380..994918,994963..995199) VIII 1 NT_166533.1 Complex: the Sip3 protein from S. cerevisae interacts with the famous protein kinase of the carbon source signal transduction pathway Snf1.; Remark: Sip3 from S. cerevisae is able to stimulate transcription.; Remark: alternate name for S. cerevisiae Sip3: YNL257c.; Similarity: the Sip3 protein contains a putative leucine zipper motif, thus it could be a putative transcription factor.; Title: strong similarity to Snf1 interacting protein Sip3 - Saccharomyces cerevisiae; uncharacterized protein 995199 4989988 An18g04240 Aspergillus niger uncharacterized protein XP_059602919.1 990902 D 5061 CDS An18g04250 4989989 complement(join(995452..995693,995771..996308)) VIII 1 NT_166533.1 Similarity: the similarities of the ORF encoded protein to other proteins are mainly based on repetitive structures.; Title: similarity to laminin A Lam-A - Drosophila melanogaster; extracellular/secretion proteins; See PMID 8223265; See PMID 1744083; uncharacterized protein 996308 4989989 An18g04250 Aspergillus niger uncharacterized protein XP_059602920.1 995452 R 5061 CDS An18g04260 4989990 join(996999..997039,997106..998171) VIII 1 NT_166533.1 Localization: the proteins, which are showing a strong similarity to the ORF encoded protein e. g. S. cerevisiae YPL244c are probable membrane proteins.; Similarity: the ORF encoded portein shows strong similarities to some probable UDP-galactose transporters.; Title: similarity to secreted protein HNTME13 from patent WO9839446-A2 - Homo sapiens; extracellular/secretion proteins; uncharacterized protein 998171 4989990 An18g04260 Aspergillus niger uncharacterized protein XP_001398884.3 996999 D 5061 CDS An18g04270 4989991 complement(join(998352..998506,998609..998711,998932..999048)) VIII 1 NT_166533.1 Catalytic activity: Peptidylproline (omega=180) <=> peptidylproline (omega=0).; Function: peptidyl prolyl cis/trans isomerase HPAR14 from human catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.; Similarity: HPAR14 from H. sapiens is a parvulin-like peptidyl prolyl cis/trans isomerase.; Title: strong similarity to peptidyl-prolyl cis/trans isomerase HPAR14 - Homo sapiens; See PMID 10100858; uncharacterized protein 999048 4989991 An18g04270 Aspergillus niger uncharacterized protein XP_001398885.1 998352 R 5061 CDS An18g04280 4989992 join(1000422..1000566,1000818..1000861,1000953..1001567) VIII 1 NT_166533.1 Title: strong similarity to hypothetical protein CG6144 - Drosophila melanogaster; uncharacterized protein 1001567 4989992 An18g04280 Aspergillus niger uncharacterized protein XP_001398886.3 1000422 D 5061 CDS An18g04290 4989993 complement(join(1001628..1001987,1002106..1002561,1002652..1002750)) VIII 1 NT_166533.1 Remark: alternate name for S. cerevisiae Dfg10: YIL049w.; Remark: diploid S. cerevisiae strains starved for nitrogen undergo a developmental transition from growth as single yeast form (YF) cells to a multicellular form consisting of filaments of pseudohyphal (PH) cells.; Remark: the DFG10 gene was found in a screen for mutant strains defective for filamentous growth.; Title: similarity to protein required for filamentous growth, cell polarity, and cellular elongation Dfg10 - Saccharomyces cerevisiae; See PMID 9055077; uncharacterized protein 1002750 4989993 An18g04290 Aspergillus niger uncharacterized protein XP_059602921.1 1001628 R 5061 CDS An18g04295 84593707 join(1004447..1004458,1004587..1004727,1004815..1004832) VIII 1 NT_166533.1 hypothetical protein 1004832 84593707 An18g04295 Aspergillus niger hypothetical protein XP_059602922.1 1004447 D 5061 CDS An18g04300 4989995 join(1006160..1009765,1009817..1010044) VIII 1 NT_166533.1 Function: h-caldesmon from Gallus gallus plays a vital role in the regulation of smooth muscle and nonmuscle actin-myosin interaction; Remark: Gallus gallus=chicken.; Similarity: the similarities of the ORF encoded protein to other proteins are mainly based on repetitive structures.; Title: similarity to h-caldesmon - Gallus gallus; cytoskeleton; See PMID 2760048; uncharacterized protein 1010044 4989995 An18g04300 Aspergillus niger uncharacterized protein XP_059602923.1 1006160 D 5061 CDS An18g04310 4989996 join(1010431..1010433,1010532..1010856,1010932..1011056) VIII 1 NT_166533.1 Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S12 - Sus scrofa; cytoplasm; See PMID 7622064; 40S ribosomal protein eS12 1011056 4989996 An18g04310 Aspergillus niger 40S ribosomal protein eS12 XP_001398890.1 1010431 D 5061 CDS An18g04320 4989997 complement(join(1011618..1013420,1013622..1013645)) VIII 1 NT_166533.1 Function: the Vid24 protein from S. cerevisiae is involved in vacuolar targeting of fructose-1,6-bisphosphatase (FBPase) containing vesicles. Vid24p dependent protein sorting is probably mediated by the ubiquitin conjugating system.; Remark: alternate name for S. cerevisiae Vid24: YBR105c.; Title: similarity to protein involved in vacuolar protein targeting Vid24 - Saccharomyces cerevisiae; intracellular transport vesicles; See PMID 9508768; uncharacterized protein 1013645 4989997 An18g04320 Aspergillus niger uncharacterized protein XP_059602924.1 1011618 R 5061 CDS An18g04330 4989998 join(1014689..1014864,1014920..1015895) VIII 1 NT_166533.1 Remark: Homoserine lactone-dependent synthesis of sigma s in E. coli can be prevented by overexpression of RspA.; Remark: the expression of sigma s (the E. coli stress specific sigma factor) is induced by homoserine lactone, a metabolite synthesized from intermediates in threonine biosynthesis.; Similarity: the RspA protein from E. coli shows also similarities to some cycloisomerases.; Title: strong similarity to starvation-sensing protein rspA - Escherichia coli; See PMID 7545940; uncharacterized protein 1015895 4989998 An18g04330 Aspergillus niger uncharacterized protein XP_001398892.1 1014689 D 5061 CDS An18g04340 4989999 complement(join(1016099..1016641,1016733..1017049,1017119..1017323,1017405..1017412,1017462..1017513)) VIII 1 NT_166533.1 Catalytic activity: uridine + H(2)O <=> uracil + D-ribose.; Remark: alternate name for S. cerevisiae Urh1: YDR400w.; Title: strong similarity to uridine nucleosidase Urh1 - Saccharomyces cerevisiae; See PMID 10501935; uncharacterized protein 1017513 4989999 An18g04340 Aspergillus niger uncharacterized protein XP_001398893.1 1016099 R 5061 CDS An18g04350 4990000 join(1017875..1018394,1018474..1019275,1019820..1020247,1020583..1020817,1020974..1021691) VIII 1 NT_166533.1 Title: similarity to hypothetical protein SPAC5D6.07c - Schizosaccharomyces pombe; uncharacterized protein 1021691 4990000 An18g04350 Aspergillus niger uncharacterized protein XP_059602925.1 1017875 D 5061 CDS An18g04360 84593708 complement(join(1023206..1023669,1023746..1024211)) VIII 1 NT_166533.1 Similarity: the similarities of the ORF encoded protein to other proteins are mainly based on repetitive structures.; Title: weak similarity to zinc-finger protein RIZ -Homo sapiens; See PMID 8643684; See PMID 10706618; uncharacterized protein 1024211 84593708 An18g04360 Aspergillus niger uncharacterized protein XP_059602926.1 1023206 R 5061 CDS An18g04365 4990001 complement(join(1024342..1024374,1024445..1024467,1024528..1025038)) VIII 1 NT_166533.1 Title: weak similarity to deubiquitinating enzyme UBPY - Mus musculus; uncharacterized protein 1025038 4990001 An18g04365 Aspergillus niger uncharacterized protein XP_059602927.1 1024342 R 5061 CDS An18g04380 84593709 join(1032069..1032113,1032329..1032345,1032402..1032681) VIII 1 NT_166533.1 hypothetical protein 1032681 84593709 An18g04380 Aspergillus niger hypothetical protein XP_059602928.1 1032069 D 5061 CDS An18g04390 84593710 join(1033344..1033418,1033729..1033802,1033836..1033958,1034087..1034135) VIII 1 NT_166533.1 hypothetical protein 1034135 84593710 An18g04390 Aspergillus niger hypothetical protein XP_059602929.1 1033344 D 5061 CDS An18g04400 4990006 complement(join(1034811..1034920,1034967..1035087,1035156..1035512,1035574..1035911,1035967..1036037,1036093..1036129,1036188..1036265,1036328..1036370,1036435..1036455,1036565..1036585)) VIII 1 NT_166533.1 Remark: the DRG gene from Xenopus laevis is highly expressed in the embryonic CNS.; Similarity: the ORF encoded protein belongs to a group of very storg conserved proteins DRG (X. laevis,mouse, rat, human) and Fun11 (S. cerevisiae), which function is still unclear.; Title: strong similarity to GTP-binding protein DRG - Xenopus laevis; See PMID 8179998; See PMID 10760581; uncharacterized protein 1036585 4990006 An18g04400 Aspergillus niger uncharacterized protein XP_059602930.1 1034811 R 5061 CDS An18g04410 4990007 join(1037205..1037465,1037549..1037632,1037712..1037849,1037948..1038005,1038079..1038194) VIII 1 NT_166533.1 Catalytic activity: L-cysteine + O(2) <=> 3-sulfinoalanine.; Cofactor: iron.; Pathway: the cysteine dioxygenase CDO1 from Rattus norvegicus the cysteine metabolism and Taurine and hypotaurine metabolism.; Title: strong similarity to cysteine dioxygenase CDO1 - Rattus norvegicus; See PMID 9654352; See PMID 2334417; uncharacterized protein 1038194 4990007 An18g04410 Aspergillus niger uncharacterized protein XP_059602931.1 1037205 D 5061 CDS An18g04420 4990008 complement(join(1038809..1038925,1038993..1039668,1039718..1040469,1040541..1041134,1041206..1041312,1041386..1041413,1041472..1041501)) VIII 1 NT_166533.1 Catalytic activity: UDP-glucose + glycogenin <=> UDP + glucosylglycogenin.; Complex: the human glycogenin is sub-unit of the glycogen synthase.; Similarity: the ORF encoded protein is c-terminal extended in comparison to its homologues.; Similarity: the ORF encoded protein shows similarity to the Caenorhabditis elegans glycogenin described in patent WO9850553-A1.; Title: similarity to glycogenin 1 GYG - Homo sapiens; See PMID 8602861; See PMID 10644553; uncharacterized protein 1041501 4990008 An18g04420 Aspergillus niger uncharacterized protein XP_059602932.1 1038809 R 5061 CDS An18g04430 4990009 complement(join(1042440..1042709,1042817..1043248,1043303..1043772,1043868..1044021)) VIII 1 NT_166533.1 Catalytic activity: an epoxide + H(2)O <=> a glycol.; Title: similarity to soluble epoxide hydrolase sEH clone EH3.1 - Solanum tuberosum; See PMID 7920715; See PMID 8678300; uncharacterized protein 1044021 4990009 An18g04430 Aspergillus niger uncharacterized protein XP_059602933.1 1042440 R 5061 CDS An18g04440 4990010 complement(join(1044826..1044877,1044942..1046719)) VIII 1 NT_166533.1 Function: Filobasidiella neoformans produces a thick extracellular polysaccharide capsule, which is well recognized as a virulence factor. CAP10 from Filobasidiella neoformans is required for capsule formation.; Remark: Filobasidiella neoformans=Cryptococcus neoformans.; Title: strong similarity to capsular associated protein CAP10 - Filobasidiella neoformans; cytoplasm; See PMID 10482503; uncharacterized protein 1046719 4990010 An18g04440 Aspergillus niger uncharacterized protein XP_059602934.1 1044826 R 5061 CDS An18g04450 4990011 complement(join(1047156..1047191,1047703..1048313,1048364..1048609,1048719..1048872)) VIII 1 NT_166533.1 Title: similarity to hypothetical protein encoded by An11g07910 - Aspergillus niger; uncharacterized protein 1048872 4990011 An18g04450 Aspergillus niger uncharacterized protein XP_059602935.1 1047156 R 5061 CDS An18g04460 4990012 complement(1049902..1051479) VIII 1 NT_166533.1 Title: strong similarity to hypothetical protein B2O8.250 - Neurospora crassa; uncharacterized protein 1051479 4990012 An18g04460 Aspergillus niger uncharacterized protein XP_001398906.1 1049902 R 5061 CDS An18g04470 4990013 join(1053037..1053504,1053566..1054219,1054354..1055553) VIII 1 NT_166533.1 Function: S. cerevisiae Tbf1 binds to TTAGGG repeats. It essential for cell growth and may play a role in telomere function and/or structure. It may regulate gene expression.; Remark: alternate names for S. cerevisiae Tbf1: Lpi16 or YPL128C.; Title: strong similarity to TTAGGG repeat binding factor Tbf1 - Saccharomyces cerevisiae; nucleus; See PMID 8423796; See PMID 10871401; uncharacterized protein 1055553 4990013 An18g04470 Aspergillus niger uncharacterized protein XP_059602936.1 1053037 D 5061 CDS An18g04480 4990014 join(1056257..1056625,1056748..1057001,1057080..1057206) VIII 1 NT_166533.1 Complex: the human TAFII30 protein belongs to the basic RNAPolII transcription factor TFIID. TFIID is composed of TATA Binding Protein (TBP) and a number of TBP-associated factors (TAFs).; Function: TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.; Title: strong similarity to subunit of transcription initiation factor TFIID TAFII30 - Homo sapiens; nucleus; See PMID 7923369; uncharacterized protein 1057206 4990014 An18g04480 Aspergillus niger uncharacterized protein XP_059602937.1 1056257 D 5061 CDS An18g04490 4990015 complement(join(1057863..1057905,1058095..1058277,1058436..1058451,1058526..1058568)) VIII 1 NT_166533.1 Function: the E. coli S19 ribosomal subunit forms a complex with S13 that binds strongly to the 16S ribosomal RNA.; Similarity: the ORF encoded protein shows strong similarity to the probable mitochondrial ribosomal S19 proteins from S. cerevisiae (YNR037c) and S. pombe (SPAC1751. 02c).; Title: similarity to ribosomal protein of the small subunit s19 rpsS - Escherichia coli; localisation:mitochondrion; See PMID 348496; mitochondrial 37S ribosomal protein uS19m 1058568 4990015 An18g04490 Aspergillus niger mitochondrial 37S ribosomal protein uS19m XP_001398909.1 1057863 R 5061 CDS An18g04520 4990018 complement(join(1060461..1061700,1061844..1061929)) VIII 1 NT_166533.1 Function: the S. cerevisiae transcriptional regulator Arg82 also has inositol polyphosphate multikinase (ipmk) activity, it is still unclear how this activity is involved in the regulatory network.; Remark: alternate names for S. cerevisiae Arg82: ArgRIII, Ipk2 or YDR173C.; Title: similarity to regulator protein of the arginin metabolism Arg82 - Saccharomyces cerevisiae; nucleus; See PMID 10632874; See PMID 11119723; See PMID 2274024; See PMID 3298999; uncharacterized protein 1061929 4990018 An18g04520 Aspergillus niger uncharacterized protein XP_001398910.1 1060461 R 5061 CDS An18g04530 4990019 join(<1064147..1064656,1064707..1064792,1064913..1065161,1065210..1066077) VIII 1 NT_166533.1 Remark: N-terminally truncated ORF due to the end of contig.; Title: similarity to hypothetical protein SPAC13F5.10 - Schizosaccharomyces pombe [truncated ORF]; uncharacterized protein 1066077 4990019 An18g04530 Aspergillus niger uncharacterized protein XP_059602938.1 1064147 D 5061 CDS An18g04540 4990020 complement(join(1066224..1066446,1066521..1067296)) VIII 1 NT_166533.1 Catalytic activity: NADPH + quinone <=> NADP(+) + semiquinone.; Remark: the E. coli QOR protein is the homolog of the mammalian zeta-crystallin which has NADPH:quinone reductase activity and which is also an important structual component of the eye-lens.; Title: strong similarity to quinone oxidoreductase QOR - Escherichia coli; See PMID 7602590; uncharacterized protein 1067296 4990020 An18g04540 Aspergillus niger uncharacterized protein XP_001398912.1 1066224 R 5061 CDS An18g04550 4990021 1069272..1071545 VIII 1 NT_166533.1 Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: the similarities of the ORF encoded protein to MUC1 from yeast and the other proteins are mainly based on repetitive stretches in the sequence.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942; uncharacterized protein 1071545 4990021 An18g04550 Aspergillus niger uncharacterized protein XP_001398913.1 1069272 D 5061 CDS An18g04560 4990022 complement(1071637..1072566) VIII 1 NT_166533.1 Catalytic activity: N-acetyl-D-glucosamine + H(2)O <=> D-glucosamine + acetate.; Remark: Pneumococci in which pgdA was inactivated produce fully N-acetylated glycan and become hypersensitive to exogenous lysozyme in the stationary phase of growth.; Title: similarity to peptidoglycan GlcNAc deacetylase PgdA - Streptococcus pneumoniae; See PMID 10781617; uncharacterized protein 1072566 4990022 An18g04560 Aspergillus niger uncharacterized protein XP_001398914.1 1071637 R 5061 CDS An18g04570 4990023 complement(join(1072933..1072962,1073095..1073264,1073397..1073825,1073885..1074440,1074537..1074647,1074740..1074877)) VIII 1 NT_166533.1 Complex: the S. cerevisiae Clp1 protein is part of the cleavage factor IA complex involved premessenger RNA 3'-end formation which also contains Rna14, Rna15, Pcf11 and the major poly(A)-binding protein Pab1.; Remark: alternate name for S. cerevisiae Clp1: YOR250C.; Title: strong similarity to cleavage/polyadenylation factor IA subunit Clp1 - Saccharomyces cerevisiae; nucleus; See PMID 9223284; uncharacterized protein 1074877 4990023 An18g04570 Aspergillus niger uncharacterized protein XP_059602939.1 1072933 R 5061 CDS An18g04580 4990024 complement(join(1075732..1075756,1075815..1076661,1076711..1076873,1076938..1077224,1077259..1077319)) VIII 1 NT_166533.1 Remark: the ORF encoded protein shows repetitive structures.; Title: similarity to neurofilament polypeptide H -Oryctolagus cuniculus; See PMID 1512270; uncharacterized protein 1077319 4990024 An18g04580 Aspergillus niger uncharacterized protein XP_059602940.1 1075732 R 5061 CDS An18g04590 4990025 join(1079229..1079319,1079597..1079919,1079978..1080026,1080096..1080226) VIII 1 NT_166533.1 Function: Rdi1 from S. cerevisiae regulates the GDP/GTP exchange reaction of the rho-type G-proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.; Remark: alternate name for S. cerevisiae Rdi1: YDL135C.; Title: strong similarity to rho GDP dissociation inhibitor Rdi1 - Saccharomyces cerevisiae; See PMID 8051050; See PMID 9242378; uncharacterized protein 1080226 4990025 An18g04590 Aspergillus niger uncharacterized protein XP_001398917.1 1079229 D 5061 CDS An18g04600 4990026 complement(join(1081015..1081727,1081876..1082109,1082187..1082202)) VIII 1 NT_166533.1 Catalytic activity: a phosphoprotein + H(2)O <=> a protein + phosphate.; Remark: alternate names for S. cerevisiae Ppg1: PPG or YNR032W.; Similarity: S. cerevisiae Ppg1 belongs to the PPP family of phosphatases and to the PP-2a subfamily.; Title: strong similarity to catalytic chain of the phosphoprotein phosphatase PPG Ppg1 - Saccharomyces cerevisiae; See PMID 7678255; uncharacterized protein 1082202 4990026 An18g04600 Aspergillus niger uncharacterized protein XP_001398918.1 1081015 R 5061 CDS An18g04610 4990027 complement(join(1083018..1083669,1083811..1085261,1085330..1085487,1085566..1085605)) VIII 1 NT_166533.1 Complex: the 'Assembly Protein Complex 3' (AP-3) is a heterotetramer composed of two large chains (delta and beta3=beta-NAP), a medium chain (mu3) and a small chain (sigma3).; Function: the human beta-NAP protein is part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. This complex is associated with the golgi region as well as more peripheral structures. Beta-NAP facilitates the budding of vesicles from the golgi membrane and may be directly involved in trafficking to lysosomes.; Remark: alternate names for the human neuron-specific vesicle coat protein beta-NAP: beta-adaptin 3b or AP-3 complex beta3b subunit.; Title: strong similarity to neuron-specific vesicle coat protein and cerebellar degeneration antigen beta-NAP -Homo sapiens; intracellular transport vesicles; See PMID 767130; uncharacterized protein 1085605 4990027 An18g04610 Aspergillus niger uncharacterized protein XP_059602941.1 1083018 R 5061 CDS An18g04620 4990028 complement(join(1086671..1087936,1087994..1088257)) VIII 1 NT_166533.1 Function: the MCT3 transporter from Rattus norvegicus is a proton-linked monocarboxylate transporter. It catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate,branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate,beta-hydroxybutyrate and acetate.; Title: strong similarity to monocarboxylate transporter MCT3 - Rattus norvegicus; plasma membrane; See PMID 9632638; See PMID 9841555; uncharacterized protein 1088257 4990028 An18g04620 Aspergillus niger uncharacterized protein XP_001398920.1 1086671 R 5061 CDS An18g04630 84593711 join(1088830..1088847,1088955..1089027,1089203..1089380,1089435..1089510) VIII 1 NT_166533.1 Remark: alternate name for S. cerevisiae Trp5: YGL026C.; Similarity: the ORF encoded protein only shows significant similarity to the C-terminal part of the S. cerevisiae Trp5 product (also to its homologs). The homology to Trp5 does not extent upstream of the startcodon. The ORF seems to encode a strong shorter version of a Trp5-like tryptophan synthase. Surprisingly N. crassa also has a shorter version of a TRP5-like gene which encodes a protein of a comparable length (TREMBL:AF084905_1; 138 AA).; Title: similarity to tryptophan synthase Trp5 -Saccharomyces cerevisiae; See PMID 6276387; See PMID 6381966; uncharacterized protein 1089510 84593711 An18g04630 Aspergillus niger uncharacterized protein XP_059602942.1 1088830 D 5061 CDS An18g04640 4990030 complement(join(1090826..1090939,1090993..1091907,1091980..1092240,1092297..1092398)) VIII 1 NT_166533.1 Function: S. cerevisiae Nuf2 is a spindle pole body-associated protein required for nuclear division. It is involved in spindle pole body separation and spindle elongation.; Remark: alternate name for S. cerevisiae Nuf2: YOL069W.; Title: strong similarity to spindle pole body protein Nuf2 - Saccharomyces cerevisiae; centrosome; See PMID 8188751; uncharacterized protein 1092398 4990030 An18g04640 Aspergillus niger uncharacterized protein XP_001398922.1 1090826 R 5061 CDS An18g04650 4990031 join(1092758..1092804,1092871..1093885) VIII 1 NT_166533.1 Complex: S. cerevisiae Gcn3 is component of the GCD complex with five different subunits; alpha (Gcn3), beta (Gcd7), gamma (Gcd1), delta (Gcd2) and epsilon (Gcd6).; Function: S. cerevisiae Gcn3 is nonessential component of the high-molecular-weight GCD complex which activates the synthesis of Gcn4 (transcription factor) in yeast under amino acid starvation conditions by suppressing the inhibitory effects of multiple AUG codons present in the leader of GCN4 mRNA. It may promote either repression or activation of Gcn4 expression depending on amino acid availability. The modulation of Gcn3 regulatory function in response to amino acid availability occurs posttranslationally.; Remark: alternate names for S. cerevisiae Gcn3: Aas2 or YKR026C.; Similarity: S. cerevisiae Gcn3 belongs to the eIf-2b alpha/beta/delta subunits family.; Title: strong similarity to guanine nucleotide exchange factor eIF-2B 34 kDa alpha subunit Gcn3 -Saccharomyces cerevisiae; cytoplasm; See PMID 8506384; See PMID 3062370; uncharacterized protein 1093885 4990031 An18g04650 Aspergillus niger uncharacterized protein XP_001398923.1 1092758 D 5061 CDS An18g04660 4990032 join(1094969..1095091,1095126..1095586,1095644..1096348,1096402..1096757,1096789..1096847) VIII 1 NT_166533.1 Catalytic activity: acyl-CoA + cholesterol <=> CoA + cholesterol ester.; Remark: alternate names for S. cerevisiae Sat1: Are2 or YNR019W.; Title: strong similarity to sterol o-acyltransferase Sat1 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 8650549; See PMID 8798656; See PMID 10672016; uncharacterized protein 1096847 4990032 An18g04660 Aspergillus niger uncharacterized protein XP_059602943.1 1094969 D 5061 CDS An18g04670 4990033 complement(join(1097851..1098124,1098187..1098475,1098548..1099065,1099129..1099205,1099259..1099342)) VIII 1 NT_166533.1 Golgi; Localization: expression of the human transporter cDNA in CHO-K1 cells in its native and in a C-terminally HA-tagged form indicated that the human UDP-GlcNAc transporter was localized in the Golgi apparatus.; Similarity: the ORF DNA sequence shows also similarity to the E. nidulans EST m6g08a1. r1.; Title: similarity to UDP-N-acetylglucosamine transporter SLC35A3 - Homo sapiens; See PMID 10393322; uncharacterized protein 1099342 4990033 An18g04670 Aspergillus niger uncharacterized protein XP_059602944.1 1097851 R 5061 CDS An18g04680 84593712 join(1099366..1099384,1099407..1099797,1099893..1100187) VIII 1 NT_166533.1 Remark: blast results are not significant.; Title: weak similarity to hypothetical nonstructural protein V - Newcastle disease virus; uncharacterized protein 1100187 84593712 An18g04680 Aspergillus niger uncharacterized protein XP_059602945.1 1099366 D 5061 CDS An18g04690 4990035 complement(join(1100312..1101718,1101788..1104634,1104696..1104755,1104931..1105056)) VIII 1 NT_166533.1 Localization: mastermind accumulates predominantly in the nucleus.; Remark: mastermind of D. virilis is a neurogenic gene which is required for proper partitioning of ectodermal cells into epidermal versus neural lineages.; Remark: nearly half of the protein sequence of mastermind consists of only three amino acids: glutamine,glycine, and asparagine.; Similarity: blast hits result from repetitive sequences, ORF might be to long.; Title: similarity to protein mastermind - Drosophila virilis; nucleus; See PMID 1701150; uncharacterized protein 1105056 4990035 An18g04690 Aspergillus niger uncharacterized protein XP_059602946.1 1100312 R 5061 CDS An18g04700 84593713 1105063..1105380 VIII 1 NT_166533.1 hypothetical protein 1105380 84593713 An18g04700 Aspergillus niger hypothetical protein XP_059602947.1 1105063 D 5061 CDS An18g04710 84593714 join(1105438..1105554,1105655..1105771,1105843..1105880,1106052..1106246,1106553..1106646,1106711..1106827,1106916..1106957) VIII 1 NT_166533.1 Remark: blast hits result from repetitive seq.; Title: weak similarity to hypothetical retinitis pigmentosa GTPase regulator RPGR - Homo sapiens; uncharacterized protein 1106957 84593714 An18g04710 Aspergillus niger uncharacterized protein XP_059602948.1 1105438 D 5061 CDS An18g04720 84593715 join(1108604..1108637,1108779..1108852) VIII 1 NT_166533.1 Remark: the ORF is short in length (35 amino acids) and has an unusual exon/intron structure for A. niger.; Title: questionable ORF; uncharacterized protein 1108852 84593715 An18g04720 Aspergillus niger uncharacterized protein XP_059602949.1 1108604 D 5061 CDS An18g04730 4990039 join(1109446..1109747,1109826..1111559,1111682..1111709) VIII 1 NT_166533.1 Title: strong similarity to hypothetical protein SPCC622.11 - Schizosaccharomyces pombe; uncharacterized protein 1111709 4990039 An18g04730 Aspergillus niger uncharacterized protein XP_001398931.3 1109446 D 5061 CDS An18g04740 84593716 join(1112106..1112138,1112431..1112472,1112560..1112646,1112736..1112784,1112962..1113056) VIII 1 NT_166533.1 Title: questionable ORF; uncharacterized protein 1113056 84593716 An18g04740 Aspergillus niger uncharacterized protein XP_059602950.1 1112106 D 5061 CDS An18g04750 4990041 1113533..1114474 VIII 1 NT_166533.1 Similarity: weak similarity to apolipoprotein A-IV I isoform of Papio hamadryas.; Title: strong similarity to hypothetical protein 8D4.210 - Neurospora crassa; See PMID 8101842; uncharacterized protein 1114474 4990041 An18g04750 Aspergillus niger uncharacterized protein XP_001398933.3 1113533 D 5061 CDS An18g04760 84593717 join(1114776..1115012,1115104..1115207,1115433..1115589) VIII 1 NT_166533.1 hypothetical protein 1115589 84593717 An18g04760 Aspergillus niger hypothetical protein XP_059602951.1 1114776 D 5061 CDS An18g04770 84593718 complement(join(1116351..1116514,1116606..1116630)) VIII 1 NT_166533.1 Remark: blast hits result from repetitive sequences.; hypothetical protein 1116630 84593718 An18g04770 Aspergillus niger hypothetical protein XP_059602952.1 1116351 R 5061 CDS An18g04780 4990044 join(1117143..1117241,1117357..1118856) VIII 1 NT_166533.1 Title: similarity to hypothetical protein 68B2.200 -Neurospora crassa; uncharacterized protein 1118856 4990044 An18g04780 Aspergillus niger uncharacterized protein XP_059602953.1 1117143 D 5061 CDS An18g04790 4990045 join(1119531..1119585,1119689..1119787,1119889..1120049) VIII 1 NT_166533.1 Function: acts as glutathione-disulfide oxidoreductase in the presence of NADPH and glutathione reductase and reduces low molecular weight proteins and disulfides.; Title: strong similarity to thioltransferase glutaredoxin - Oryza sativa; See PMID 8287970; uncharacterized protein 1120049 4990045 An18g04790 Aspergillus niger uncharacterized protein XP_001398937.1 1119531 D 5061 CDS An18g04800 4990046 complement(join(1120221..1121744,1121824..1122647,1122814..1122988,1123042..1123914)) VIII 1 NT_166533.1 Remark: rhaA of A. aculeatus hydrolyzes alpha-1,2 and alpha-1,6 linkages to beta-D-glucosides.; Remark: the ORF is longer than rhaA of A. aculeatus (1131 compared to 660 amino acids).; Title: strong similarity to alpha-L-rhamnosidase A precursor rhaA - Aspergillus aculeatus; See PMID 11319105; uncharacterized protein 1123914 4990046 An18g04800 Aspergillus niger uncharacterized protein XP_059602954.1 1120221 R 5061 CDS An18g04810 4990047 join(1124523..1124786,1124841..1125207,1125272..1125471,1125524..1125964) VIII 1 NT_166533.1 Title: strong similarity to exo-polygalacturonase PGX from patent WO9414966-A - Aspergillus tubingensis; cytoplasm; See PMID 8856078; uncharacterized protein 1125964 4990047 An18g04810 Aspergillus niger uncharacterized protein XP_001398939.1 1124523 D 5061 CDS An18g04820 84593719 1127741..1128223 VIII 1 NT_166533.1 hypothetical protein 1128223 84593719 An18g04820 Aspergillus niger hypothetical protein XP_059602955.1 1127741 D 5061 CDS An18g04830 84593720 join(1130483..1130655,1130945..1131012,1131182..1131260,1131342..1131390) VIII 1 NT_166533.1 Remark: gene structure questionable; Title: questionable ORF; uncharacterized protein 1131390 84593720 An18g04830 Aspergillus niger uncharacterized protein XP_059602956.1 1130483 D 5061 CDS An18g04840 4990050 complement(join(1131735..1132843,1132900..1133038,1133101..1133230,1133299..1133303)) VIII 1 NT_166533.1 Function: translation elongation, protein biosynthesis.; Remark: possible sequencing error.; Title: strong similarity to translation elongation factor 1 alpha - Podospora anserina [putative sequencing error]; cytoplasm; See PMID 8289244; uncharacterized protein 1133303 4990050 An18g04840 Aspergillus niger uncharacterized protein XP_003188975.1 1131735 R 5061 CDS An18g04850 4990051 complement(join(1135139..1135174,1135248..1135342,1135447..1135656,1135729..1135741)) VIII 1 NT_166533.1 Complex: hRPC11 is a small, essential subunit RNA polymerase III. hRPC11 is specific for PolIII.; Function: RNA polymerase III deprived of hRPC11,initiates transcription properly but ignores pause sites and is defective in termination. Pol III delta lacks the intrinsic RNA cleavage activity of complete Pol III.; Similarity: the predicted A. niger protein shows strong similarity to human RNA polymerase III subunit (hRPC11) and related highly conserved proteins.; Title: strong similarity to RNA polymerase III subunit hRPC11 - Homo sapiens; nucleus; See PMID 9869639; uncharacterized protein 1135741 4990051 An18g04850 Aspergillus niger uncharacterized protein XP_001398943.1 1135139 R 5061 CDS An18g04860 84593721 complement(join(1135854..1135937,1136021..1136139,1136279..1136327)) VIII 1 NT_166533.1 hypothetical protein 1136327 84593721 An18g04860 Aspergillus niger hypothetical protein XP_059602957.1 1135854 R 5061 CDS An18g04870 4990053 join(1136417..1136440,1136485..1136662,1136761..1137086) VIII 1 NT_166533.1 Title: weak similarity to death-associated protein kinase DAPK - Homo sapiens; See PMID 7828849; uncharacterized protein 1137086 4990053 An18g04870 Aspergillus niger uncharacterized protein XP_059602958.1 1136417 D 5061 CDS An18g04880 4990054 complement(join(1137392..1138035,1138105..1138318)) VIII 1 NT_166533.1 Title: similarity to hypothetical protein SPCC645.04 - Schizosaccharomyces pombe; uncharacterized protein 1138318 4990054 An18g04880 Aspergillus niger uncharacterized protein XP_001398946.3 1137392 R 5061 CDS An18g04900 84593722 complement(join(1139451..1139594,1139660..1139749,1139923..1140012)) VIII 1 NT_166533.1 hypothetical protein 1140012 84593722 An18g04900 Aspergillus niger hypothetical protein XP_059602959.1 1139451 R 5061 CDS An18g04910 4990057 complement(join(1140253..1140415,1140465..1140740,1140805..1140910,1140972..1141857,1141938..1142003,1142121..1142150)) VIII 1 NT_166533.1 Title: similarity to monocarboxylate transporter MCT2 - Rattus norvegicus; See PMID 9182702; uncharacterized protein 1142150 4990057 An18g04910 Aspergillus niger uncharacterized protein XP_001398948.3 1140253 R 5061 CDS An18g04920 84593723 join(1142438..1142534,1142618..1142924,1143001..1143108,1143326..1143446,1143526..1143762) VIII 1 NT_166533.1 hypothetical protein 1143762 84593723 An18g04920 Aspergillus niger hypothetical protein XP_059602960.1 1142438 D 5061 CDS An18g04930 84593724 complement(join(1143918..1144004,1144082..1144186)) VIII 1 NT_166533.1 Title: similarity to secreted protein yb7_1 - Homo sapiens; uncharacterized protein 1144186 84593724 An18g04930 Aspergillus niger uncharacterized protein XP_059602961.1 1143918 R 5061 CDS An18g04950 84593725 join(1146311..1146348,1146415..1146496,1146584..1146691,1146739..1146852) VIII 1 NT_166533.1 hypothetical protein 1146852 84593725 An18g04950 Aspergillus niger hypothetical protein XP_059602962.1 1146311 D 5061 CDS An18g04960 84593726 complement(join(1147104..1147342,1147590..1147940,1148051..1148186,1148398..1148517)) VIII 1 NT_166533.1 Remark: Similarity possibly caused by structural domain.; Title: weak similarity to hypothetical protein Y54E5A.7 - Caenorhabditis elegans; uncharacterized protein 1148517 84593726 An18g04960 Aspergillus niger uncharacterized protein XP_059602963.1 1147104 R 5061 CDS An18g04970 84593727 join(1148533..1149171,1149223..1149343,1149585..1149670) VIII 1 NT_166533.1 Title: weak similarity to subtilisin E precursor aprE - Bacillus subtilis; uncharacterized protein 1149670 84593727 An18g04970 Aspergillus niger uncharacterized protein XP_059602964.1 1148533 D 5061 CDS An18g05000 4990066 complement(join(1151185..1151676,1151744..1151818)) VIII 1 NT_166533.1 Remark: a splice site was detected upstream of the START codon.; Title: strong similarity to host infection protein cap20 - Colletotrichum gloeosporioides; See PMID 7756829; uncharacterized protein 1151818 4990066 An18g05000 Aspergillus niger uncharacterized protein XP_001398954.1 1151185 R 5061 CDS An18g05010 84593728 join(1151946..1151959,1152048..1152112,1152334..1152414,1152509..1152730,1152820..1152943,1153241..1153378,1153513..1153671,1153811..1153965,1154064..1154070,1154147..1154283,1154359..1154450,1154549..1154611,1154700..1154843) VIII 1 NT_166533.1 hypothetical protein 1154843 84593728 An18g05010 Aspergillus niger hypothetical protein XP_059602965.1 1151946 D 5061 CDS An18g05020 4990068 complement(join(1155392..1155399,1155472..1155808,1156046..1156101,1156178..1156184)) VIII 1 NT_166533.1 Remark: belongs to the 60S large ribosomal subunit.; Title: strong similarity to cytoplasmic ribosomal protein of the large subunit Rpl27 - Saccharomyces cerevisiae; cytoplasm; See PMID 10590466; 60S ribosomal protein eL27 1156184 4990068 An18g05020 Aspergillus niger 60S ribosomal protein eL27 XP_001398956.1 1155392 R 5061 CDS An18g05030 84593729 complement(join(1156329..1156434,1156479..1156544,1156594..1156679)) VIII 1 NT_166533.1 hypothetical protein 1156679 84593729 An18g05030 Aspergillus niger hypothetical protein XP_059602966.1 1156329 R 5061 CDS An18g05040 4990070 join(1156973..1157021,1157046..1160045,1160073..1163857,1163942..1163998) VIII 1 NT_166533.1 Function: the golgin family of coiled-coil proteins function in Rab6-regulated membrane-tethering events.; Golgi; Localization: human golgin proteins target to the Golgi apparatus through a carboxy-terminal domain containing a conserved tyrosine residue, which is critical for targeting.; Similarity: the predicted A. niger protein shows strong similarity to human golgin 245 and similarities to several coiled-coil proteins, e. g. human centromere protein E, human giantin and myosin heavy chains of different organisms.; Title: strong similarity to golgin-245 - Homo sapiens; See PMID 8537393; See PMID 10209123; uncharacterized protein 1163998 4990070 An18g05040 Aspergillus niger uncharacterized protein XP_059602967.1 1156973 D 5061 CDS An18g05050 4990071 join(1164707..1165190,1165258..1165940) VIII 1 NT_166533.1 Title: strong similarity to hypothetical protein encoded by B7F18.130 - Neurospora crassa; uncharacterized protein 1165940 4990071 An18g05050 Aspergillus niger uncharacterized protein XP_059602968.1 1164707 D 5061 CDS An18g05060 4990072 complement(join(1166770..1167294,1167364..1168277,1168350..1168446)) VIII 1 NT_166533.1 Remark: similarity to component of human SWI/SNF-like chromatin-remodeling protein complexes; Title: strong similarity to SWI/SNF-related,matrix-associated, actin-dependent regulator of chromatin SMARCD1 - Homo sapiens; See PMID 8804307; uncharacterized protein 1168446 4990072 An18g05060 Aspergillus niger uncharacterized protein XP_001398960.1 1166770 R 5061 CDS An18g05070 4990073 complement(join(1168815..1169821,1169886..1170153)) VIII 1 NT_166533.1 Title: strong similarity to 26S proteasome subunit 9 - Homo sapiens; cytoplasm; See PMID 9119060; uncharacterized protein 1170153 4990073 An18g05070 Aspergillus niger uncharacterized protein XP_001398961.1 1168815 R 5061 CDS An18g05080 4990074 join(1170504..1170506,1170564..1171543,1171605..1171965) VIII 1 NT_166533.1 Remark: SOF1 yeast protein is involved in rRNA processing. Protein shows also considerable similarity to 3-ISOPROPYLMALATE DEHYDROGENASE of S. pombe.; Title: strong similarity to protein Sof1 -Saccharomyces cerevisiae; nucleus; See PMID 8508778; uncharacterized protein 1171965 4990074 An18g05080 Aspergillus niger uncharacterized protein XP_059602969.1 1170504 D 5061 CDS An18g05090 4990075 complement(join(1172110..1172754,1172857..1173375)) VIII 1 NT_166533.1 Remark: Similarity to murine short-chain dehydrogenase/reductase that reduces all-trans-retinal in cone photoreceptors.; Title: similarity to retinal short-chain dehydrogenase/reductase retSDR1 - Mus musculus; See PMID 9705317; uncharacterized protein 1173375 4990075 An18g05090 Aspergillus niger uncharacterized protein XP_001398963.1 1172110 R 5061 CDS An18g05100 4990076 1174028..1175413 VIII 1 NT_166533.1 Title: similarity to cytosine deaminase codA -Escherichia coli; See PMID 8450832; uncharacterized protein 1175413 4990076 An18g05100 Aspergillus niger uncharacterized protein XP_001398964.1 1174028 D 5061 CDS An18g05110 4990077 complement(1175636..1177621) VIII 1 NT_166533.1 Title: weak similarity to polycomblike protein XPcl2 - Xenopus laevis; uncharacterized protein 1177621 4990077 An18g05110 Aspergillus niger uncharacterized protein XP_059602970.1 1175636 R 5061 CDS An18g05120 4990078 complement(join(1178076..1178287,1178350..1178643,1178695..1179199,1179261..1179381,1179452..1179483,1179548..1179715)) VIII 1 NT_166533.1 Function: bbsF of T. aromatica is part of the bbs operon, encoding enzymes of beta oxidation of the toluene catabolism intermediate benzylsuccinate.; Pathway: bbsF of T. aromatica is a component of the anaerobic toluene catabolism.; Title: strong similarity to subunit of succinyl-CoA:benzylsuccinate CoA-transferase bbsF - Thauera aromatica; See PMID 10629170; uncharacterized protein 1179715 4990078 An18g05120 Aspergillus niger uncharacterized protein XP_001398966.1 1178076 R 5061 CDS An18g05130 4990079 join(1180023..1180053,1180120..1180242,1180445..1180956,1181130..1181333) VIII 1 NT_166533.1 Remark: Carboxyterminal perhapes shorter; Title: strong similarity to riboflavin synthase Rib5 - Saccharomyces cerevisiae; See PMID 7814407; uncharacterized protein 1181333 4990079 An18g05130 Aspergillus niger uncharacterized protein XP_001398967.3 1180023 D 5061 CDS An18g05140 4990080 complement(join(1181492..1182655,1182716..1182922)) VIII 1 NT_166533.1 Remark: putative role in mating.; Title: strong similarity to hypothetical protein Ssf1 - Saccharomyces cerevisiae; uncharacterized protein 1182922 4990080 An18g05140 Aspergillus niger uncharacterized protein XP_001398968.1 1181492 R 5061 CDS An18g05150 4990081 join(1183169..1183493,1183581..1184357,1184423..1184724) VIII 1 NT_166533.1 Function: RRP3 (rRNA processing) of S. cerevisiae is required for pre-rRNA processing.; Title: strong similarity to RNA helicase-like protein Rrp3 - Saccharomyces cerevisiae; See PMID 8774901; uncharacterized protein 1184724 4990081 An18g05150 Aspergillus niger uncharacterized protein XP_001398969.1 1183169 D 5061 CDS An18g05160 84593730 complement(1185094..>1185732) VIII 1 NT_166533.1 Remark: fragment, but sequence so far obtained shows high similarity. Aminoterminus is lacking. Enzyme converts N-acetyl-D-glucosamine 1-phosphate to N-acetyl-D-glucosamine 6-phosphate.; Title: strong similarity to phosphoacetylglucosamine mutase AGM1 - Candida albicans [truncated ORF]; See PMID 8119301; uncharacterized protein 1185732 84593730 An18g05160 Aspergillus niger uncharacterized protein XP_059602971.1 1185094 R 5061 CDS An18g05170 4990083 complement(join(<1185842..1186318,1186376..1186390,1186455..1186599,1186701..1186714,1186794..1186886)) VIII 1 NT_166533.1 Catalytic activity: N-acetyl-D-glucosamine 1-phosphate -> N-acetyl-D-glucosamine 6-phosphate.; Induction: AGM1 is activated by N-acetyl-D-glucosamine 1,6-bisphosphate.; Pathway: AGM1 of C. albicans is involved in aminosugars metabolism.; Remark: AGM1 of C. albicans belongs to the phosphohexose mutase family.; Title: similarity to phosphoacetylglucosamine mutase AGM1 - Candida albicans; See PMID 11004509; uncharacterized protein 1186886 4990083 An18g05170 Aspergillus niger uncharacterized protein XP_001398971.3 1185842 R 5061 CDS An18g05180 4990084 complement(join(1187464..1187518,1187576..1188350,1188451..1188556,1188637..1188825)) VIII 1 NT_166533.1 Title: strong similarity to hypothetical membrane protein YCR044c - Saccharomyces cerevisiae; uncharacterized protein 1188825 4990084 An18g05180 Aspergillus niger uncharacterized protein XP_059606590.1 1187464 R 5061 CDS An18g05190 4990085 join(1189568..1189662,1189718..1189731,1189794..1189813,1189872..1189981,1190043..1190374,1190437..1190908,1190959..1190965) VIII 1 NT_166533.1 Function: ODP1 can catalyze both the mono- and asymmetric dimethylation in S. cerevisiae.; Function: ODP1 methylates arginines in a variety of RNA-binding proteins in S. cerevisiae.; Remark: alternate names in S. cerevisiae = RMT1,HMT1, HCP1, YBR0320, YBR034c.; Title: strong similarity to protein Odp1 -Saccharomyces cerevisiae; See PMID 8647869; uncharacterized protein 1190965 4990085 An18g05190 Aspergillus niger uncharacterized protein XP_001398973.3 1189568 D 5061 CDS An18g05200 84593731 join(1191039..1191056,1191274..1191337,1191484..1191689) VIII 1 NT_166533.1 hypothetical protein 1191689 84593731 An18g05200 Aspergillus niger hypothetical protein XP_059606591.1 1191039 D 5061 CDS An18g05210 4990087 join(1191732..1191851,1191912..1191960,1192053..1192415,1192478..1192571,1192657..1192999) VIII 1 NT_166533.1 Remark: the trifunctional protein consists of 2-Enoyl-CoA hydratase (EC 4. 2. 1. 17), L-3-hydroxyacyl-CoA dehydrogenase (EC 1. 1. 1. 35), and 3-hydroxyacyl-CoA epimerase (EC 5. 1. 2. -) in Neurospora crassa.; Title: similarity to multifunctional beta-oxidation protein - Neurospora crassa; See PMID 1830048; uncharacterized protein 1192999 4990087 An18g05210 Aspergillus niger uncharacterized protein XP_059606592.1 1191732 D 5061 CDS An18g05220 4990088 join(1193275..1193333,1193387..1193432,1193503..1193684,1193736..1193753,1193816..1193882,1193942..1194002,1194053..1194152,1194209..1194314,1194365..1194490,1194565..1195015,1195244..1195359) VIII 1 NT_166533.1 Function: gamma-butyrobetaine hydroxylase catalyzes the hydroxylation of gamma-butyrobetaine to carnitine, the last step in the biosynthesis of carnitine from lysine in Pseudomonas.; Title: strong similarity to gamma-butyrobetaine hydroxylase - Pseudomonas sp.; See PMID 1988434; uncharacterized protein 1195359 4990088 An18g05220 Aspergillus niger uncharacterized protein XP_059606593.1 1193275 D 5061 CDS An18g05230 4990089 join(1195734..1196053,1196149..1196564,1196620..1197278) VIII 1 NT_166533.1 Function: the S. cerevisiae homolog Rpt5p is subunit of the 20S proteasome regulatory particle.; Remark: proteasomes are maily localised in the in the nuclear envelope-ER network.; Title: strong similarity to proteasome 19S regulatory particle subunit Rpt5 - Saccharomyces cerevisiae; uncharacterized protein 1197278 4990089 An18g05230 Aspergillus niger uncharacterized protein XP_001398977.1 1195734 D 5061 CDS An18g05240 84593732 join(1197724..1197801,1197922..1197992,1198081..1198126,1198209..1198452,1198497..1198533,1198627..1198723,1198768..1199014,1199300..1199359,1199521..1199693,1199742..1199811,1199978..1200100,1200192..1200262,1200349..1200561,1200643..1201035,1201091..1201189) VIII 1 NT_166533.1 hypothetical protein 1201189 84593732 An18g05240 Aspergillus niger hypothetical protein XP_059606594.1 1197724 D 5061 CDS An18g05250 84593733 complement(join(1201781..1202289,1202399..1202514,1202598..1202647)) VIII 1 NT_166533.1 hypothetical protein 1202647 84593733 An18g05250 Aspergillus niger hypothetical protein XP_059606595.1 1201781 R 5061 CDS An18g05260 84593734 join(1203113..1203175,1203401..1203542,1203699..1203864,1203957..1204143) VIII 1 NT_166533.1 hypothetical protein 1204143 84593734 An18g05260 Aspergillus niger hypothetical protein XP_059606596.1 1203113 D 5061 CDS An18g05270 4990093 complement(join(1204349..1204613,1204657..1204855,1204920..1204998,1205053..1205409,1205478..1205577,1205633..1205676,1205735..1205864,1205963..1206010,1206083..1206138)) VIII 1 NT_166533.1 Catalytic activity: STY1 in Schizosaccharomyces pombe is activated by tyrosine and threonine phosphorylation (by similarity).; EC:2.7.1.-; Title: strong similarity to mitogen-activated protein kinase sty1p - Schizosaccharomyces pombe; See PMID 8557102; See PMID 10428498; uncharacterized protein 1206138 4990093 An18g05270 Aspergillus niger uncharacterized protein XP_059606597.1 1204349 R 5061 CDS An18g05280 4990094 complement(join(1206257..1206560,1206651..1206765,1206982..1207066,1208099..1208866,1208952..1209084,1209159..1209299,1209405..1209514)) VIII 1 NT_166533.1 Title: weak similarity to hypothetical protein encoded by An01g07840 - Aspergillus niger; uncharacterized protein 1209514 4990094 An18g05280 Aspergillus niger uncharacterized protein XP_001398982.3 1206257 R 5061 CDS An18g05290 84593735 join(1209762..1209843,1209968..1210014,1210100..1210162) VIII 1 NT_166533.1 Remark: the ORF is short in length (63 amino acids) and has an unusual exon/intron structure for A. niger.; Title: questionable ORF; uncharacterized protein 1210162 84593735 An18g05290 Aspergillus niger uncharacterized protein XP_059606598.1 1209762 D 5061 CDS An18g05310 84593736 complement(join(1210610..1210623,1210710..1210809,1210905..1210938,1211038..1211048)) VIII 1 NT_166533.1 hypothetical protein 1211048 84593736 An18g05310 Aspergillus niger hypothetical protein XP_059606599.1 1210610 R 5061 CDS An18g05340 4990100 complement(join(1212962..1214876,1214957..1215375)) VIII 1 NT_166533.1 Title: similarity to hypothetical protein CAD70913.1 - Neurospora crassa; uncharacterized protein 1215375 4990100 An18g05340 Aspergillus niger uncharacterized protein XP_059606600.1 1212962 R 5061 CDS An18g05350 84593737 join(1215377..1215631,1215769..1215840,1215951..1216256) VIII 1 NT_166533.1 Remark: blastp hits are random.; hypothetical protein 1216256 84593737 An18g05350 Aspergillus niger hypothetical protein XP_059606601.1 1215377 D 5061 CDS An18g05360 84593738 complement(join(1216515..1216685,1216744..1216835,1216930..1216973,1217162..1217250)) VIII 1 NT_166533.1 Remark: blastp hits are random.; hypothetical protein 1217250 84593738 An18g05360 Aspergillus niger hypothetical protein XP_059606602.1 1216515 R 5061 CDS An18g05370 84593739 complement(join(1219335..1219444,1219686..1219860)) VIII 1 NT_166533.1 hypothetical protein 1219860 84593739 An18g05370 Aspergillus niger hypothetical protein XP_059606603.1 1219335 R 5061 CDS An18g05380 4990104 complement(join(1220105..1221517,1221582..1222854,1223361..1223431)) VIII 1 NT_166533.1 Function: the sck1 gene from S. pombe is able to suppress the defects conferred by a mutation in any of these git genes.; Function: the sck1 gene from S. pombe was cloned as a high copy number suppressor of a mutation in git3 (components of an adenylate cyclase activation pathway).; Title: strong similarity to cAMP-dependent protein kinase sck1p - Schizosaccharomyces pombe; deleted EC_number 2.7.1.37; See PMID 7498728; uncharacterized protein 1223431 4990104 An18g05380 Aspergillus niger uncharacterized protein XP_059606604.1 1220105 R 5061 CDS An18g05400 84593740 join(1223563..1223645,1223748..1223864,1223959..1224048,1224315..1224343,1224429..1224626,1224684..1224797,1224879..1224976,1225049..1225105) VIII 1 NT_166533.1 Remark: blastp hits are random or based on repetetive sequence motives.; hypothetical protein 1225105 84593740 An18g05400 Aspergillus niger hypothetical protein XP_059606605.1 1223563 D 5061 CDS An18g05410 84593741 join(1225316..1225531,1226269..1226387,1226512..1226604,1226650..1226895,1226978..1227011,1227062..1227132,1227381..1227546,1227641..1227703,1227738..1227845) VIII 1 NT_166533.1 Remark: blastp hits are random; Title: questionable ORF; uncharacterized protein 1227845 84593741 An18g05410 Aspergillus niger uncharacterized protein XP_059606606.1 1225316 D 5061 CDS An18g05420 4990107 join(1228111..1228116,1228199..1228412,1228499..1229570,1229622..1230225) VIII 1 NT_166533.1 Title: similarity to nuclear localization protein Npl6 - Saccharomyces cerevisiae; See PMID 8514125; uncharacterized protein 1230225 4990107 An18g05420 Aspergillus niger uncharacterized protein XP_059606607.1 1228111 D 5061 CDS An18g05430 4990108 complement(join(1231331..1231410,1231467..1231675,1231738..1231942,1232013..1232187)) VIII 1 NT_166533.1 Function: SNF7 of S. cerevisiae is required for normal morphology and sorting activity of the endosome.; Phenotype: mutations of SNF7 in S. cerevisiae prevent full depression of the SUC2 (invertase) gene in response to glucose limitation and result in a sporulation defect in homozygous diploids.; Remark: the major functional role of SNF7 in S. cerevisiae may be related to invertase expression or glucose repression.; Title: strong similarity to endosomal protein Snf7 -Saccharomyces cerevisiae; endosome; See PMID 8224817; See PMID 9606181; See PMID 11251082; uncharacterized protein 1232187 4990108 An18g05430 Aspergillus niger uncharacterized protein XP_001398993.1 1231331 R 5061 CDS An18g05440 4990109 join(1232285..1232483,1232535..1232635,1232836..1233339) VIII 1 NT_166533.1 Remark: blastp hits are random.; hypothetical protein 1233339 4990109 An18g05440 Aspergillus niger hypothetical protein XP_059606608.1 1232285 D 5061 CDS An18g05450 4990110 complement(join(1233606..1233692,1233780..1233958,1234003..1234267,1234707..1235424,1235487..1235763,1235817..1236193,1236253..1236590)) VIII 1 NT_166533.1 Remark: alternate name in S. cerevisiae = YLL028w.; Remark: it is indicated that a membrane protein encoded by YLL028w (TPO1) is a polyamine transport protein on the vacuolar membrane in S. cerevisiae.; Title: similarity to polyamine transport protein Tpo1 - Saccharomyces cerevisiae; See PMID 9920864; See PMID 11171066; uncharacterized protein 1236590 4990110 An18g05450 Aspergillus niger uncharacterized protein XP_001398995.3 1233606 R 5061 CDS An18g05460 84593742 join(1237564..1237635,1237847..1238148,1238202..1238398,1238512..1238711,1238796..1238846,1238950..1239129,1239255..1239377,1239463..1239651) VIII 1 NT_166533.1 hypothetical protein 1239651 84593742 An18g05460 Aspergillus niger hypothetical protein XP_059606609.1 1237564 D 5061 CDS An18g05470 4990112 join(1240078..1240303,1240404..1241046,1241106..1241691) VIII 1 NT_166533.1 Catalytic activity: 3-beta-hydroxy-delta5-steroid + nad+ = 3-oxo-delta5 -steroid + nadh (acts on 3-beta-hydroxyandrost-5-en-17-one to form androst-4-ene-3,17-dione and on 3-beta-hydroxypregn -5-en-20-one to form progesterone).; Remark: alternate name in S. cerevisiae = YGL001C.; Title: similarity to C-3 sterol dehydrogenase Erg26 - Saccharomyces cerevisiae; See PMID 9811880; uncharacterized protein 1241691 4990112 An18g05470 Aspergillus niger uncharacterized protein XP_001398997.1 1240078 D 5061 CDS An18g05480 4990113 complement(join(1241908..1242039,1242145..1242329,1242420..1242548,1242632..1242917,1242993..1243053,1243110..1243725,1243783..1243826,1243885..1244138,1244201..1244354,1244409..1244551)) VIII 1 NT_166533.1 Catalytic activity: oxidation of methanol into formaldehyde and H2O2.; Function: P. pastoris, contains two alcohol oxidase genes, AOX1 and AOX2.; Function: in methylotrophic yeasts, alcohol oxidase is the first enzyme in the methanol-utilization pathway.; Similarity: show strong similarity to several fungal alcohol oxidases.; Title: strong similarity to alcohol oxidase AOX1 -Pichia pastoris; See PMID 2660463; uncharacterized protein 1244551 4990113 An18g05480 Aspergillus niger uncharacterized protein XP_001398998.1 1241908 R 5061 CDS An18g05490 4990114 complement(join(1245795..1246408,1246464..1246500)) VIII 1 NT_166533.1 Similarity: shows also similarity to corresponding human hypothetical gene product DAM1.; Title: similarity to hypothetical protein T12A2.7 -Caenorhabditis elegans; uncharacterized protein 1246500 4990114 An18g05490 Aspergillus niger uncharacterized protein XP_001398999.1 1245795 R 5061 CDS An18g05500 4990115 join(1247354..1247556,1247612..1249697) VIII 1 NT_166533.1 Function: active in neutral to alkaline range.; Function: human enzyme cleaves lipid ceramide into free fatty acid and sphingosine.; Localization: might be mitochondrial.; Title: strong similarity to mitochondrial ceramidase AAF86240.1 - Homo sapiens; uncharacterized protein 1249697 4990115 An18g05500 Aspergillus niger uncharacterized protein XP_001399000.1 1247354 D 5061 CDS An18g05510 84593743 1250553..1252403 VIII 1 NT_166533.1 Function: MUC1 of yeast is a cell surface flocculin involved in pseudohyphal differentiation and invasive growth in response to nitrogen starvation.; Localization: MUC1 of yeast is thought to be an integral membrane protein.; Phenotype: deletion of MUC1 in yeast abolishes pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is a component of a signal transduction pathway downstream of MEP2 regulating pseudohyphal differentiation and invasive growth.; Remark: MUC1 of yeast is also known as FLO11, STA4 and has a systematic name of YIR019C.; Remark: there are no hints for any MUC1 1,4-alpha-glucosidase activity in the literature.; Similarity: blast hits result from repetitive sequences.; Title: similarity to mucin-like protein Muc1 -Saccharomyces cerevisiae; See PMID 8710886; See PMID 9383611; See PMID 9987114; See PMID 11152942; uncharacterized protein 1252403 84593743 An18g05510 Aspergillus niger uncharacterized protein XP_059606610.1 1250553 D 5061 CDS An18g05520 4990117 complement(join(1252984..1253310,1253364..1254239)) VIII 1 NT_166533.1 hypothetical protein 1254239 4990117 An18g05520 Aspergillus niger hypothetical protein XP_001399002.3 1252984 R 5061 CDS An18g05530 84593744 join(1254544..1254647,1254681..1254881,1255036..1255273) VIII 1 NT_166533.1 hypothetical protein 1255273 84593744 An18g05530 Aspergillus niger hypothetical protein XP_059606611.1 1254544 D 5061 CDS An18g05540 4990119 complement(join(1257059..1257700,1257769..1257788,1257946..1258009)) VIII 1 NT_166533.1 Title: similarity to hypothetical protein B13D15.090 - Neurospora crassa; uncharacterized protein 1258009 4990119 An18g05540 Aspergillus niger uncharacterized protein XP_001399004.3 1257059 R 5061 CDS An18g05550 4990120 complement(join(1258295..1258851,1258915..1259080)) VIII 1 NT_166533.1 Function: DL-2-Haloacid dehalogenase from Pseudomonas sp. strain 113 (DL-DEX) catalyzes the hydrolytic dehalogenation of both D- and L-2-haloalkanoic acids to produce the corresponding L- and D-2-hydroxyalkanoic acids, respectively, with inversion of the C2 configuration.; Function: DL-DEX is a unique enzyme that acts on the chiral carbon of the substrate and uses both enantiomers as equivalent substrates.; Title: similarity to L-2-haloalkanoic acid dehalogenase hadL - Pseudomonas putida; See PMID 9209038; uncharacterized protein 1259080 4990120 An18g05550 Aspergillus niger uncharacterized protein XP_001399005.1 1258295 R 5061 CDS An18g05560 4990121 1259271..1259546 VIII 1 NT_166533.1 Similarity: blast hits cover only carboxyterminal part of the ORF.; Title: weak similarity to hypothetical conserved protein DR2483 - Deinococcus radiodurans; uncharacterized protein 1259546 4990121 An18g05560 Aspergillus niger uncharacterized protein XP_001399006.3 1259271 D 5061 CDS An18g05570 4990122 complement(join(1260471..1260622,1260680..1263179)) VIII 1 NT_166533.1 Catalytic activity: the E. coli enzyme catalyzes the hydrolysis of GTP in a ribosome-dependent manner.; Function: it protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.; Similarity: shows strong similarity to fungal IF2 in mitochondria, but is about 200 bp longer and is perhapes not localized in mitochondria.; Title: strong similarity to translation initiation factor IF2 infB - Escherichia coli; uncharacterized protein 1263179 4990122 An18g05570 Aspergillus niger uncharacterized protein XP_059606612.1 1260471 R 5061 CDS An18g05580 84593745 complement(1263460..1263837) VIII 1 NT_166533.1 Similarity: blast hits result from repetitive sequences.; hypothetical protein 1263837 84593745 An18g05580 Aspergillus niger hypothetical protein XP_059606613.1 1263460 R 5061 CDS An18g05590 4990124 join(1264060..1264165,1264362..1264373,1264422..1264558,1264615..1265243,1265311..1265341) VIII 1 NT_166533.1 Title: strong similarity to mitochondrial carrier protein Ymc1 - Saccharomyces cerevisiae; localisation:mitochondrion; See PMID 9559855; uncharacterized protein 1265341 4990124 An18g05590 Aspergillus niger uncharacterized protein XP_001399009.1 1264060 D 5061 CDS An18g05600 4990125 complement(join(1265692..1266329,1266409..1266518,1266654..1266753,1266875..1267029,1267079..1267385,1267439..1267550,1267607..1267622,1267685..1267821,1267870..1268086,1268164..1268223,1268280..1268311,1268392..1268421,1268555..1268617)) VIII 1 NT_166533.1 Similarity: shows similarity to proteins containing Fungal Zn(2)-Cys(6) binuclear cluster domains i. e. mainly transcriptional regulatory proteins.; Title: weak similarity to hypothetical transcriptional regulator FCR1 - Candida albicans; uncharacterized protein 1268617 4990125 An18g05600 Aspergillus niger uncharacterized protein XP_059606614.1 1265692 R 5061 CDS An18g05610 4990126 complement(join(1269031..1269244,1269390..1269454,1269510..1269607,1269655..1269676,1269724..1269991,1270044..1270157,1270212..1270283,1270340..1270392,1270441..1270503,1270568..1270665,1270726..1271248)) VIII 1 NT_166533.1 Similarity: member of the allantoate family of the major facilitator superfamily.; Title: strong similarity to allantoate permease Dal5 - Saccharomyces cerevisiae; See PMID 8720066; See PMID 3275614; uncharacterized protein 1271248 4990126 An18g05610 Aspergillus niger uncharacterized protein XP_059606615.1 1269031 R 5061 CDS An18g05620 4990127 1272100..1274643 VIII 1 NT_166533.1 Function: glucosidase II is an ER heterodimeric enzyme that cleaves sequentially the two innermost alpha-1,3-linked glucose residues from N-linked oligosaccharides on nascent glycoproteins.; Function: this processing allows the binding and release of monoglucosylated (Glc(1)Man(9)GlcNAc(2)) glycoproteins with calnexin and calreticulin, the lectin-like chaperones of the endoplasmic reticulum.; Similarity: family 31 comprises of enzymes that are,or similar to, alpha- galactosidases.; Title: strong similarity to glucosidase II alpha subunit AAF66685.1 - Homo sapiens; See PMID 10929008; uncharacterized protein 1274643 4990127 An18g05620 Aspergillus niger uncharacterized protein XP_001399012.1 1272100 D 5061 CDS An18g05630 4990128 complement(join(1275100..1275986,1276062..1276259,1276328..1276355)) VIII 1 NT_166533.1 Similarity: ribosomal S2 proteins have been shown to belong to a family that includes 40S ribosomal subunit 40kD proteins, putative laminin-binding proteins, NAB-1 protein and 29. 3Kd protein from Haloarcula marismortui.; Title: similarity to mitochondrial ribosomal protein of the small subunit S2 Mrp4 - Saccharomyces cerevisiae; See PMID 1531984; mitochondrial 37S ribosomal protein uS2m 1276355 4990128 An18g05630 Aspergillus niger mitochondrial 37S ribosomal protein uS2m XP_001399013.1 1275100 R 5061 CDS An18g05640 4990129 complement(join(1278113..1278413,1278473..1278768)) VIII 1 NT_166533.1 Similarity: shows also similarity to probable nitrogen starvation-induced glutamine rich protein of C. gloeosporioides.; Title: strong similarity to hypothetical mold-specific protein MS8 - Ajellomyces capsulatus; uncharacterized protein 1278768 4990129 An18g05640 Aspergillus niger uncharacterized protein XP_001399014.1 1278113 R 5061 CDS An18g05650 10098278 join(1281331..1281577,1281651..1281873,1282011..1282124,1282282..1282492,1282603..1282686,1282817..1284301) VIII 1 NT_166533.1 Function: drosophila protein is important in the structural and functional integrity of the sperm tail.; Similarity: similarity only partial.; Title: similarity to sperm tail-specific protein mst101 - Drosophila hydei; See PMID 7957199; uncharacterized protein 1284301 10098278 An18g05650 Aspergillus niger uncharacterized protein XP_059606616.1 1281331 D 5061 CDS An18g05660 4990131 complement(join(1284797..1284824,1284965..1285380)) VIII 1 NT_166533.1 hypothetical protein 1285380 4990131 An18g05660 Aspergillus niger hypothetical protein XP_059606617.1 1284797 R 5061 CDS An18g05670 4990132 complement(join(1286667..1286797,1286857..1287122,1287279..1287556)) VIII 1 NT_166533.1 Function: NADH:ubiquinone oxidoreductase (complex I) of the respiratory chain from the inner mitochondrial membrane of S. tuberosum.; Title: strong similarity to 23 kD subunit of NADH:ubiquinone reductase - Bos taurus; localisation:mitochondrion; uncharacterized protein 1287556 4990132 An18g05670 Aspergillus niger uncharacterized protein XP_001399017.1 1286667 R 5061 CDS An18g05680 4990133 join(1287927..1288145,1288250..1288267,1288357..1288437,1288501..1288549,1288632..1288792) VIII 1 NT_166533.1 Function: the acyl-carrier protein ACP of Neurospora crassa is a subunit of NADH:ubiquinone reductase (complex I), but is also discussed to be involved in fatty acid biosynthesis as known for other soluble acyl-carrier proteins.; Phenotype: the loss of the acp-1 gene in N. crassa causes two biochemical lesions; firstly, the peripheral part of complex I is not assembled, and the membrane part is not properly assembled. Secondly, the lysophospholipid content of mitochondrial membranes is increased four-fold. In S. cerevisiae, the loss of ACP1 leads to a pleiotropic respiratory deficient phenotype.; Similarity: the predicted ORF 38 amino acids longer at the C-terminus than the N. crassa protein.; Title: strong similarity to 9.6 kD subunit of NADH:ubiquinone reductase ACP - Neurospora crassa; localisation:mitochondrion; See PMID 9175861; See PMID 1397269; uncharacterized protein 1288792 4990133 An18g05680 Aspergillus niger uncharacterized protein XP_059606618.1 1287927 D 5061 CDS An18g05690 4990134 join(1289898..1290167,1290255..1290501,1290598..1291091,1291148..1291198) VIII 1 NT_166533.1 Title: strong similarity to hypothetical protein YDR372c - Saccharomyces cerevisiae; uncharacterized protein 1291198 4990134 An18g05690 Aspergillus niger uncharacterized protein XP_001399019.1 1289898 D 5061 CDS An18g05700 4990135 complement(join(1292293..1292342,1292656..1293733,1294042..1294099,1294131..1295392)) VIII 1 NT_166533.1 Similarity: only partial similarities found.; Title: strong similarity to hypothetical protein CAD70818.1 - Neurospora crassa; uncharacterized protein 1295392 4990135 An18g05700 Aspergillus niger uncharacterized protein XP_059606619.1 1292293 R 5061 CDS An18g05710 4990136 join(1296665..1296933,1296984..1297806) VIII 1 NT_166533.1 hypothetical protein 1297806 4990136 An18g05710 Aspergillus niger hypothetical protein XP_001399021.1 1296665 D 5061 CDS An18g05715 84593746 complement(join(1297827..1297838,1297960..1298133)) VIII 1 NT_166533.1 hypothetical protein 1298133 84593746 An18g05715 Aspergillus niger hypothetical protein XP_059606620.1 1297827 R 5061 CDS An18g05720 4990138 join(1298396..1298776,1298834..1299303,1299352..1299469,1299514..1299692,1299744..1300122) VIII 1 NT_166533.1 Title: strong similarity to hypothetical protein YBR214w - Saccharomyces cerevisiae; uncharacterized protein 1300122 4990138 An18g05720 Aspergillus niger uncharacterized protein XP_001399023.1 1298396 D 5061 CDS An18g05730 4990139 complement(join(1304012..1305215,1305277..1305344)) VIII 1 NT_166533.1 Similarity: blast hits result from repetitive sequences.; hypothetical protein 1305344 4990139 An18g05730 Aspergillus niger hypothetical protein XP_001399024.3 1304012 R 5061 CDS An18g05740 4990140 complement(join(1308190..1308390,1308479..1308988,1309105..1309461,1309523..1309795,1309855..1310148,1310242..1310317,1310388..1310475,1310585..1310651)) VIII 1 NT_166533.1 Function: it binds directly to activated, GTP bound Arf proteins.; Function: it can alter membrane transport through the trans-Golgi.; Golgi; Localization: human protein localizes to the trans-Golgi network.; Title: similarity to ARF binding protein GGA2 - Homo sapiens; See PMID 10749927; uncharacterized protein 1310651 4990140 An18g05740 Aspergillus niger uncharacterized protein XP_059606621.1 1308190 R 5061 CDS An18g05750 4990141 join(1311009..1311262,1311344..1311480,1311549..1312294) VIII 1 NT_166533.1 Title: similarity to hypothetical protein YOR006c -Saccharomyces cerevisiae; uncharacterized protein 1312294 4990141 An18g05750 Aspergillus niger uncharacterized protein XP_001399026.1 1311009 D 5061 CDS An18g05760 4990142 complement(join(1312727..1312737,1312834..1313442,1313494..1313880,1313944..1313992,1314069..1314231,1314357..1314463)) VIII 1 NT_166533.1 Title: strong similarity to hypothetical protein SPCC1840.04 - Schizosaccharomyces pombe; uncharacterized protein 1314463 4990142 An18g05760 Aspergillus niger uncharacterized protein XP_059606622.1 1312727 R 5061 CDS An18g05770 4990143 complement(join(1315377..1315489,1315584..1316245,1316313..1316685,1316740..1317076,1317186..1317352,1317442..1317685)) VIII 1 NT_166533.1 Function: studies with S. cerevisiae conditional mutants revealed that Cct7 is required for assembly of microtubules and actin in vivo.; Title: strong similarity to component of chaperonin-containing T-complex Cct7 - Saccharomyces cerevisiae; cytoplasm; See PMID 8771707; uncharacterized protein 1317685 4990143 An18g05770 Aspergillus niger uncharacterized protein XP_059606623.1 1315377 R 5061 CDS An18g05780 4990144 join(1320477..1320672,1320709..1321321,1321391..1321404,1321464..1322284) VIII 1 NT_166533.1 Title: similarity to lanthionine synthase C-like protein 1 LANCL1 - Homo sapiens; See PMID 9512664; See PMID 10944443; uncharacterized protein 1322284 4990144 An18g05780 Aspergillus niger uncharacterized protein XP_059606624.1 1320477 D 5061 CDS An18g05790 4990145 complement(1322531..1323340) VIII 1 NT_166533.1 hypothetical protein 1323340 4990145 An18g05790 Aspergillus niger hypothetical protein XP_059606625.1 1322531 R 5061 CDS An18g05800 4990146 1324236..1326719 VIII 1 NT_166533.1 Similarity: shows only similarity to the N-terminal aminoacids 140-280 of the human TIL4 protein.; Title: weak similarity to Toll/interleukin-1 receptor-like protein TIL4 - Homo sapiens; uncharacterized protein 1326719 4990146 An18g05800 Aspergillus niger uncharacterized protein XP_001399031.3 1324236 D 5061 CDS An18g05810 4990147 complement(join(1327265..1327370,1327457..1327559,1327840..1327967,1328238..1328260)) VIII 1 NT_166533.1 Title: strong similarity to cytoplasmic ribosomal protein of the small subunit S26 - Homo sapiens; cytoplasm; See PMID 7945460; See PMID 8706699; 40S ribosomal protein eS26 1328260 4990147 An18g05810 Aspergillus niger 40S ribosomal protein eS26 XP_001399032.1 1327265 R 5061 CDS An18g05820 4990148 join(1329253..1329303,1329461..1330334,1330395..1330489,1330542..1331351) VIII 1 NT_166533.1 Title: strong similarity to hypothetical protein SPAC24C9.05c - Schizosaccharomyces pombe; uncharacterized protein 1331351 4990148 An18g05820 Aspergillus niger uncharacterized protein XP_001399033.3 1329253 D 5061 CDS An18g05830 4990149 join(1332440..1332622,1332812..1333034,1333098..1333273,1333340..1333771,1333825..1335890,1335950..1336157) VIII 1 NT_166533.1 Function: the S. cerevisiae homolog is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins.; Function: the S. cerevisiae homolog plays a role in protein secretion.; Title: strong similarity to protein secretion enhancer Pse-1 - Saccharomyces cerevisiae; uncharacterized protein 1336157 4990149 An18g05830 Aspergillus niger uncharacterized protein XP_001399034.1 1332440 D 5061 CDS An18g05840 4990150 complement(join(1336534..1336917,1337007..1337555,1337629..1337973)) VIII 1 NT_166533.1 Title: similarity to alcohol-acetaldehyde dehydrogenase adhE - Lactococcus lactis; See PMID 9620952; uncharacterized protein 1337973 4990150 An18g05840 Aspergillus niger uncharacterized protein XP_001399035.1 1336534 R 5061 CDS An18g05850 4990151 complement(join(1338420..1338575,1338629..1338814,1338863..1339076,1339126..1339295,1339342..1339620,1339667..1339691,1339753..1339834,1339904..1340123)) VIII 1 NT_166533.1 Title: strong similarity to hypothetical protein SPAC30C2.08 - Schizosaccharomyces pombe; uncharacterized protein 1340123 4990151 An18g05850 Aspergillus niger uncharacterized protein XP_001399036.1 1338420 R 5061 CDS An18g05860 4990152 join(1340628..1340696,1340911..1340988,1341122..1341254,1341341..1341387) VIII 1 NT_166533.1 Function: the A. alternata homologue plays an important role in the elongation step of protein synthesis. Subunit: p1 and p2 exist as dimers at the large ribosomal subunit.; Similarity: the A. alternata homologue belongs to the l12p family of ribosomal proteins.; Title: strong similarity to cytoplasmic acidic ribosomal protein p1 - Alternaria alternata; cytoplasm; ribosomal protein P1 1341387 4990152 An18g05860 Aspergillus niger ribosomal protein P1 XP_001399037.1 1340628 D 5061 CDS An18g05870 4990153 complement(join(1342192..1342338,1342398..1342456,1342517..1342566,1342624..1343231,1343292..1343402)) VIII 1 NT_166533.1 Title: strong similarity to hypothetical membrane protein YOL092w - Saccharomyces cerevisiae; uncharacterized protein 1343402 4990153 An18g05870 Aspergillus niger uncharacterized protein XP_001399038.1 1342192 R 5061 CDS An18g05880 4990154 complement(join(1344285..1345848,1345954..1346498)) VIII 1 NT_166533.1 Function: Nulp1 from M. musculus may have a distinct role in embryonic development of many organs, including the adult brain.; Title: similarity to nucleolar protein Nulp1 - Mus musculus; nucleus; See PMID 12107429; uncharacterized protein 1346498 4990154 An18g05880 Aspergillus niger uncharacterized protein XP_059606626.1 1344285 R 5061 CDS An18g05890 4990155 join(1346931..1347607,1347669..1348688,1348742..1348853) VIII 1 NT_166533.1 Catalytic activity: [Pyruvate dehydrogenase (lipoamide)] phosphate + H2O = [Pyruvate dehydrogenase (lipoamide)] + Orthophosphate.; Title: similarity to pyruvate dehydrogenase phosphatase isoenzyme 1 PDP1 - Rattus norvegicus; localisation:mitochondrion; See PMID 9651365; uncharacterized protein 1348853 4990155 An18g05890 Aspergillus niger uncharacterized protein XP_001399040.1 1346931 D 5061 CDS An18g05900 4990156 complement(1349588..1350610) VIII 1 NT_166533.1 Function: Cox18p of S. cerevisiae is a new member of a group of mitochondrial proteins that function at a late stage of the cytochrome c oxidase assembly pathway.; Remark: the systematic genename of S. cerevisiae COX18 is YGR062C.; Title: similarity to assembly factor of cytochrome c oxidase Cox18 - Saccharomyces cerevisiae; See PMID 10809734; uncharacterized protein 1350610 4990156 An18g05900 Aspergillus niger uncharacterized protein XP_001399041.1 1349588 R 5061 CDS An18g05910 4990157 join(1351009..1351343,1351398..1351533,1351588..1352754) VIII 1 NT_166533.1 Title: strong similarity to hypothetical glycosyl transferase SPCC330.08 - Schizosaccharomyces pombe; uncharacterized protein 1352754 4990157 An18g05910 Aspergillus niger uncharacterized protein XP_001399042.3 1351009 D 5061 CDS An18g05920 4990158 complement(join(1354043..1355046,1355112..1356411)) VIII 1 NT_166533.1 Function: Crz1p in S. cerevisiae induces genes confering tolerance to high Ca2+, Mn2+, Na+, and cell wall damage.; Induction: Crz1p in S. cerevisiae is activated by the Ca2+/calmodulin binding protein phosphatase calcineurin.; Remark: CRZ1 of S. cerevisiae is also called TCN1.; Remark: the systematic name of CRZ1 from S. cerevisiae is YNL027w.; Similarity: shows strong similarity to Crz1p around the zinc-finger region and weak similarity in the glutamine-rich N-terminal region.; Title: similarity to calcineurin responsive zinc-finger transcription factor Crz1 - Saccharomyces cerevisiae; See PMID 9407035; See PMID 9407036; uncharacterized protein 1356411 4990158 An18g05920 Aspergillus niger uncharacterized protein XP_001399043.1 1354043 R 5061 CDS An18g05930 4990159 join(1357362..1357629,1357908..1357945) VIII 1 NT_166533.1 Title: questionable ORF; uncharacterized protein 1357945 4990159 An18g05930 Aspergillus niger uncharacterized protein XP_001399044.3 1357362 D 5061 CDS An18g05940 4990160 complement(join(1359623..1360351,1360423..1360746)) VIII 1 NT_166533.1 Catalytic activity: arabinogalactan endo-1,4-beta-galactosidase catalyzes the endohydrolysis of 1,4-beta-D-galactosidic linkages in arabinogalactans.; Pathway: beta-1,4-galactanase of A. aculeatus degrades unsubstituted galactan to galactose and galactobiose.; Remark: arabinogalactan endo-1,4-beta-galactosidase of A. aculeatus is also called beta-1,4-galactanase.; Similarity: nearly identical to galA of Aspergillus tubingensis, but the experimental evidence is not accessible via PubMed.; Title: strong similarity to arabinogalactan endo-1,4-beta-galactosidase gal1 - Aspergillus aculeatus; See PMID 7788716; See PMID 8520117; See PMID 10089338; uncharacterized protein 1360746 4990160 An18g05940 Aspergillus niger uncharacterized protein XP_001399045.3 1359623 R 5061 CDS An18g05950 84593747 complement(join(1361004..1361264,1361369..1361512)) VIII 1 NT_166533.1 hypothetical protein 1361512 84593747 An18g05950 Aspergillus niger hypothetical protein XP_059602972.1 1361004 R 5061 CDS An18g05960 4990162 complement(join(1362172..1365136,1365222..1365532)) VIII 1 NT_166533.1 Function: ssp1 of S. pombe is involved in the regulation of cortical actin redistribution during the change from monopolar to bipolar growth.; Title: strong similarity to serine/threonine-specific protein kinase ssp1p -Schizosaccharomyces pombe; cytoplasm; See PMID 7628434; uncharacterized protein 1365532 4990162 An18g05960 Aspergillus niger uncharacterized protein XP_059602973.1 1362172 R 5061 CDS An18g05970 84593748 complement(join(1367301..1367348,1367456..1367533,1367598..1367601,1367662..1367679,1367818..1367831,1367987..1368040,1368342..1368533)) VIII 1 NT_166533.1 Title: strong similarity to EST an_1522 -Aspergillus niger; uncharacterized protein 1368533 84593748 An18g05970 Aspergillus niger uncharacterized protein XP_059602974.1 1367301 R 5061 CDS An18g05980 4990164 complement(join(1368872..1369024,1369087..1369221,1369305..1369502,1369637..1369664,1369744..1369811)) VIII 1 NT_166533.1 Function: GTP-bound Rho1p of S. pombe binds to the amino-terminal HR-1 motifs of the protein kinase C homologs Pkc1p and Pkc2p thereby stabilizing the kinases.; Function: Rho1 is involved in actin patch localization, maintenance of cell polarity, the regulation of septation, and cell wall synthesis.; Localization: Rho1p of S. pombe is located to the peripheral membrane at the growing tips during interphase and at the septum prior to cytokinesis.; Pathway: Rho1p of S. pombe is involved in the activation of (1-3)beta-D-glucan synthase which is a key enzyme for cell wall growth.; Title: strong similarity to GTP-binding protein rho1p - Schizosaccharomyces pombe; See PMID 9372443; See PMID 9491802; See PMID 10504305; See PMID 7698654; uncharacterized protein 1369811 4990164 An18g05980 Aspergillus niger uncharacterized protein XP_001399049.1 1368872 R 5061 CDS An18g05990 84593749 join(1369880..1369948,1370029..1370078,1370229..1370457) VIII 1 NT_166533.1 Similarity: the Gly/Arg/Glu-rich domain in the N-terminal half of the ORF shares homology with a similar domain of the 70K U1 small nuclear ribonucleoprotein of Drosophila melanogaster.; Title: weak similarity to hypothetical protein SC4G6.36 - Streptomyces coelicolor; uncharacterized protein 1370457 84593749 An18g05990 Aspergillus niger uncharacterized protein XP_059602975.1 1369880 D 5061 CDS An18g06000 84593750 join(1372715..1372827,1372918..1373105,1373184..1373263) VIII 1 NT_166533.1 hypothetical protein 1373263 84593750 An18g06000 Aspergillus niger hypothetical protein XP_059602976.1 1372715 D 5061 CDS An18g06010 4990167 join(1374472..1374888,1374953..1375588) VIII 1 NT_166533.1 Remark: mitochondrial ribosomal proteins (MRPs) are the counterparts in that organelle of the cytoplasmic ribosomal proteins in the host. Although the MRPs fulfil similar functions in protein biosynthesis, they are distinct in number, features and primary structures from the latter. Most progress in the eludication of the properties of individual MRPs, and in the characterization of the corresponding genes, has been made in baker's yeast (S. cerevisiae).; Title: similarity to ribosomal protein of the large subunit Yml40 - Saccharomyces cerevisiae; See PMID 9151978; See PMID 9445368; See PMID 2060626; mitochondrial 54S ribosomal protein uL24m 1375588 4990167 An18g06010 Aspergillus niger mitochondrial 54S ribosomal protein uL24m XP_001399052.1 1374472 D 5061 CDS An18g06020 4990168 join(1376080..1376185,1376283..1376615,1376681..1377037,1377100..1377680) VIII 1 NT_166533.1 Remark: strong similarity to EST an_1617 from Aspergillus niger.; Title: strong similarity to hypothetical protein YNL206c - Saccharomyces cerevisiae; uncharacterized protein 1377680 4990168 An18g06020 Aspergillus niger uncharacterized protein XP_001399053.1 1376080 D 5061 CDS An18g06030 84593751 join(1378059..1378181,1378317..1378532,1378663..1378705,1379080..1379137,1379259..1379361) VIII 1 NT_166533.1 hypothetical protein 1379361 84593751 An18g06030 Aspergillus niger hypothetical protein XP_059602977.1 1378059 D 5061 CDS An18g06040 84593752 complement(join(1379867..1379984,1380303..1380346,1380506..1380541,1380642..1380738,1380821..1380953,1381097..1381207,1381309..1381438)) VIII 1 NT_166533.1 Remark: only repetitiv sequences are matching.; Title: weak similarity to hypothetical protein W02H5.e - Caenorhabditis elegans; uncharacterized protein 1381438 84593752 An18g06040 Aspergillus niger uncharacterized protein XP_059602978.1 1379867 R 5061 CDS An18g06050 4990171 join(1381588..1381716,1381772..1381841,1381901..1382049,1382106..1382511,1382573..1383149,1383229..1383601) VIII 1 NT_166533.1 Remark: subcellular fractionation experiments demonstrate that Cki1 and Cki2 are both cytoplasmic enzymes that do not overlap in subcellular distribution and that probably play distinct roles within the cell.; Similarity: belongs to the protein kinase family.; Title: strong similarity to casein kinase i homolog cki1p - Schizosaccharomyces pombe; See PMID 8163505; uncharacterized protein 1383601 4990171 An18g06050 Aspergillus niger uncharacterized protein XP_059602979.1 1381588 D 5061 CDS An18g06060 84593753 complement(join(1384154..1384448,1384822..1384853,1384946..1385030,1385581..1385712,1385822..1385940)) VIII 1 NT_166533.1 Title: similarity to EST an_1045 - Aspergillus niger; uncharacterized protein 1385940 84593753 An18g06060 Aspergillus niger uncharacterized protein XP_059602980.1 1384154 R 5061 CDS An18g06070 84593754 complement(join(1387201..1387412,1388047..1388107)) VIII 1 NT_166533.1 Title: questionable ORF; uncharacterized protein 1388107 84593754 An18g06070 Aspergillus niger uncharacterized protein XP_059602981.1 1387201 R 5061 CDS An18g06080 84593755 complement(join(1388651..1388871,1388972..1389063,1389114..1389301,1389381..1389532,1389649..1389796,1389836..1389901,1390006..1390098,1390180..1390246,1390332..1390462)) VIII 1 NT_166533.1 hypothetical protein 1390462 84593755 An18g06080 Aspergillus niger hypothetical protein XP_059602982.1 1388651 R 5061 CDS An18g06085 84593756 join(1390798..1390974,1391044..1391286) VIII 1 NT_166533.1 hypothetical protein 1391286 84593756 An18g06085 Aspergillus niger hypothetical protein XP_059602983.1 1390798 D 5061 CDS An18g06090 84593757 complement(join(1391305..1391337,1391423..1391479,1391548..1391673)) VIII 1 NT_166533.1 Title: similarity to EST an_3223 - Aspergillus niger; uncharacterized protein 1391673 84593757 An18g06090 Aspergillus niger uncharacterized protein XP_059602984.1 1391305 R 5061 CDS An18g06100 84593758 complement(join(1391864..1392056,1392158..1392252,1392328..1392410,1392927..1393020,1393106..1393222,1393317..1393412,1393547..1393674,1393758..1393838,1393999..1394029)) VIII 1 NT_166533.1 Title: weak similarity to hypothetical protein AAG28022.1 - Theileria parva; uncharacterized protein 1394029 84593758 An18g06100 Aspergillus niger uncharacterized protein XP_059602985.1 1391864 R 5061 CDS An18g06110 4990178 1394218..1395321 VIII 1 NT_166533.1 Title: strong similarity to hypothetical related a-agglutinin core protein AGA1 - Neurospora crassa; uncharacterized protein 1395321 4990178 An18g06110 Aspergillus niger uncharacterized protein XP_001399063.1 1394218 D 5061 CDS An18g06115 84593759 1395638..1395862 VIII 1 NT_166533.1 hypothetical protein 1395862 84593759 An18g06115 Aspergillus niger hypothetical protein XP_059602986.1 1395638 D 5061 CDS An18g06120 4990180 complement(join(1396460..1397130,1397266..1397338,1397389..1397727,1397783..1397882,1397982..1398094,1398175..1398333)) VIII 1 NT_166533.1 Remark: strong similarity to cDNA encoding human secreted protein vc33_1, SEQ ID NO:41 patent WO200011015-A1.; Title: strong similarity to secreted protein vc33_1 from patent WO200011015-A1 - Homo sapiens; uncharacterized protein 1398333 4990180 An18g06120 Aspergillus niger uncharacterized protein XP_059602987.1 1396460 R 5061 CDS An18g06130 4990181 complement(join(1399163..1399446,1399511..1399586)) VIII 1 NT_166533.1 Title: weak similarity to small subunit mitochondrial ribosomal protein Ymr31 - Saccharomyces cerevisiae; uncharacterized protein 1399586 4990181 An18g06130 Aspergillus niger uncharacterized protein XP_001399066.1 1399163 R 5061 CDS An18g06140 84593760 join(1399644..1399733,1399793..1399984) VIII 1 NT_166533.1 hypothetical protein 1399984 84593760 An18g06140 Aspergillus niger hypothetical protein XP_059602988.1 1399644 D 5061 CDS An18g06150 84593761 complement(join(1400125..1400433,1400551..1400637)) VIII 1 NT_166533.1 hypothetical protein 1400637 84593761 An18g06150 Aspergillus niger hypothetical protein XP_059602989.1 1400125 R 5061 CDS An18g06160 4990184 join(1401211..1401704,1401789..1402110) VIII 1 NT_166533.1 Function: SRB5 transcription factor that has an important role in basal and activated transcription in vitro and is essential for efficient establishment of the transcription initiation apparatus. The SRB-TBP complex binds specifically to the c-terminal domain of RNA polymerase II (ctd) in forming the transcription initiation complex. SRB2 and SRB5 are found to bind directly to TBP and are, thus, integral components of the preinitiation complex.; Title: similarity to RNA polymerase II suppressor protein Srb5 - Saccharomyces cerevisiae; uncharacterized protein 1402110 4990184 An18g06160 Aspergillus niger uncharacterized protein XP_001399069.1 1401211 D 5061 CDS An18g06170 4990185 join(1402548..1402641,1402702..1402859,1402941..1403053,1403131..1403436,1403494..1403621,1403698..1403837,1404004..1404085,1404317..1404462,1404739..1404903) VIII 1 NT_166533.1 Catalytic activity: ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA.; Remark: mammalian polynucleotide kinases catalyze the 5'-phosphorylation of nucleic acids and can have associated 3'-phosphatase activity, predictive of an important function in DNA repair following ionizing radiation or oxidative damage.; Title: strong similarity to polynucleotide kinase-3-phosphatase PNKP - Homo sapiens; See PMID 10446192; uncharacterized protein 1404903 4990185 An18g06170 Aspergillus niger uncharacterized protein XP_059602990.1 1402548 D 5061 CDS An18g06180 84593762 join(1405804..1406175,1406267..1406344) VIII 1 NT_166533.1 hypothetical protein 1406344 84593762 An18g06180 Aspergillus niger hypothetical protein XP_059602991.1 1405804 D 5061 CDS An18g06190 4990187 complement(join(1406405..1407609,1407719..1407968)) VIII 1 NT_166533.1 Remark: only prolin and serin are matching in the corresponding proteins.; Title: weak similarity to hypothetical proteophosphoglycan ppg3 - Leishmania major; uncharacterized protein 1407968 4990187 An18g06190 Aspergillus niger uncharacterized protein XP_001399072.3 1406405 R 5061 CDS An18g06200 84593763 join(1408084..1408235,1408321..1408402,1408556..1408930,1409455..1409667,1409831..1410087,1410231..1410353,1410508..1410672,1410842..1410941) VIII 1 NT_166533.1 hypothetical protein 1410941 84593763 An18g06200 Aspergillus niger hypothetical protein XP_059602992.1 1408084 D 5061 CDS An18g06210 4990189 1411417..1412667 VIII 1 NT_166533.1 Catalytic activity: N2-acetyl-L-ornithine + H2O = acetate + L-ornithine.; Pathway: urea cycle and metabolism of amino groups.; Remark: the E. coli argE-encoded N-acetyl-L-ornithine deacetylase has a relatively broad substrate specificity with a number of alpha-N-acyl-L-amino acids exhibiting activity, including both alpha-N-acetyl-and alpha-N-formylmethionine that exhibit higher activity than alpha-N-acetyl-L-ornithine.; Title: strong similarity to acetylornithine deacetylase argE - Escherichia coli; See PMID 10684608; uncharacterized protein 1412667 4990189 An18g06210 Aspergillus niger uncharacterized protein XP_001399074.1 1411417 D 5061 CDS An18g06220 4990190 complement(join(1413137..1413403,1413506..1413680,1413774..1414182,1414238..1414882,1414959..1415274)) VIII 1 NT_166533.1 Catalytic activity: hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2.; Pathway: glycoprotein biosynthesis.; Remark: MNS1 is the structural gene for the specific alpha-mannosidase and its activity is not essential for viability.; Similarity: belongs to the hydrolase family 47.; Title: strong similarity to alpha-mannosidase Mns1 -Saccharomyces cerevisiae; See PMID 1714453; uncharacterized protein 1415274 4990190 An18g06220 Aspergillus niger uncharacterized protein XP_059602993.1 1413137 R 5061 CDS An18g06230 4990191 complement(join(1416525..1416645,1416711..1417167,1417229..1417615,1417718..1417934)) VIII 1 NT_166533.1 Similarity: belongs to the ATPases of the AAA+ class.; Title: strong similarity to proteasome 19S regulatory particle subunit Rpt4 - Saccharomyces cerevisiae; See PMID 10464306; uncharacterized protein 1417934 4990191 An18g06230 Aspergillus niger uncharacterized protein XP_001399076.1 1416525 R 5061 CDS An18g06240 84593764 complement(join(1418229..1418382,1418545..1418667,1418691..1418883,1418983..1419087,1419130..1419181,1419295..1419369,1419443..1419496)) VIII 1 NT_166533.1 Title: weak similarity to EST SEQ ID NO:4252 from patent WO200056762-A2 - Aspergillus niger; uncharacterized protein 1419496 84593764 An18g06240 Aspergillus niger uncharacterized protein XP_059602994.1 1418229 R 5061 CDS An18g06250 4990193 join(1419553..1419676,1419752..1419808,1419886..1420225,1420289..1420729,1420793..1421147) VIII 1 NT_166533.1 Catalytic activity: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O; 3-phospho-D-erythronate = phosphoenol-4-deoxy-3-tetrulosonate + H2O.; Pathway: glycolysis / gluconeogenesis; phenylalanine, tyrosine and tryptophan biosynthesis.; Remark: enolase, a glycolytic enzyme that catalyzes the dehydration of 2-phospho-d-glycerate (PGA) to form phosphoenolpyruvate (PEP), is a homodimer in all eukaryotes and many prokaryotes.; Similarity: belongs to the enolase family.; Title: strong similarity to phosphopyruvate hydratase ENO1 - Candida albicans; See PMID 8478328; See PMID 1400228; uncharacterized protein 1421147 4990193 An18g06250 Aspergillus niger uncharacterized protein XP_001399078.1 1419553 D 5061 CDS An18g06260 4990194 join(1421636..1421654,1421757..1421830,1421979..1422686) VIII 1 NT_166533.1 Remark: eukaryotic translation initiation factor 3 (eIF3) is a large multisubunit complex that plays a central role in the initiation of translation. It binds to 40 S ribosomal subunits resulting in dissociation of 80 S ribosomes, stabilizes initiator methionyl-tRNA binding to 40 S subunits, and is required for mRNA binding. eIF3 has an aggregate molecular mass of approximately 600 kDa and comprises at least 10 subunits.; Title: similarity to eukaryotic translation initiation factor eIF3 subunit p35 - Homo sapiens; See PMID 9822659; uncharacterized protein 1422686 4990194 An18g06260 Aspergillus niger uncharacterized protein XP_001399079.1 1421636 D 5061 CDS An18g06270 4990195 complement(join(1423686..1424042,1424099..1424186,1424268..1424542,1424632..1424643,1424705..1424724,1424787..1424833,1424901..1424908,1425100..1425111)) VIII 1 NT_166533.1 Function: over-expression of artA in A. nidulans causes a severe delay in the polarization of conidiospores.; Title: strong similarity to 14-3-3 protein homolog artA - Aspergillus nidulans; See PMID 12023078; uncharacterized protein 1425111 4990195 An18g06270 Aspergillus niger uncharacterized protein XP_001399080.1 1423686 R 5061 CDS An18g06280 84593765 complement(join(1425414..1425523,1425767..1425915,1426153..1426206,1426319..1426452,1426493..1426547,1426960..1427154,1427449..1427510)) VIII 1 NT_166533.1 hypothetical protein 1427510 84593765 An18g06280 Aspergillus niger hypothetical protein XP_059602995.1 1425414 R 5061 CDS An18g06290 4990197 join(1427616..1427733,1427802..1427959,1428032..1430347,1430409..1430731,1430790..1430901) VIII 1 NT_166533.1 Similarity: A. niger EST EMBLEST:BE760558 covers part of exon 4, confirms the structure of exon5, and contains part of the putative 3'UTR of the gene.; Similarity: interestingly, the predicted ORF, as well as nca-1 of N. crassa, show much stronger similarity to these animal-type Ca2+ pumps than to the plant or yeast homologues (as e. g. S. cerevisiae ENA5).; Similarity: the predicted ORF is about 75% identical to the N. crassa nca-1; the function of this enzyme is poorly characterized.; Similarity: the predicted ORF shows very strong similarity to a panoply of animal P-type sarco-endoplasmic reticulum Ca2+ ATPases, all required to sequester Ca2+ from the cytoplasm into the ER, thus providing the intracellular Calcium dynamic homeostasis required for most cellular physiological responses in a variety of biological processes.; Title: strong similarity to calcium P-type ATPase nca-1 - Neurospora crassa; See PMID 10712689; See PMID 11302372; See PMID 11389677; See PMID 1384045; uncharacterized protein 1430901 4990197 An18g06290 Aspergillus niger uncharacterized protein XP_001399082.1 1427616 D 5061 CDS An18g06300 84593766 complement(join(1431374..1431634,1431733..1431834,1431923..1432027)) VIII 1 NT_166533.1 hypothetical protein 1432027 84593766 An18g06300 Aspergillus niger hypothetical protein XP_059602996.1 1431374 R 5061 CDS An18g06310 4990199 join(1432163..1432297,1432359..1432459,1432516..1432733,1432817..1433161,1433236..1433466,1433578..1433990) VIII 1 NT_166533.1 Function: fucP in E. coli is the L-fucose (6-deoxy-L-galactose) - H+ symporter required for import of L-fucose from the extracellular environment.; Similarity: within the large superfamily of Major Facilitators, the FucP protein of E. coli, together with few similar bacterial proteins, constitute a peculiar small subgroup of transport proteins, displaying few structural similarity to other transporters.; Title: strong similarity to L-fucose permease fucP -Escherichia coli; plasma membrane; See PMID 8052131; See PMID 2553671; See PMID 2664711; uncharacterized protein 1433990 4990199 An18g06310 Aspergillus niger uncharacterized protein XP_001399084.1 1432163 D 5061 CDS An18g06320 4990200 complement(join(1434932..1437177,1437235..1437382,1437444..1437590)) VIII 1 NT_166533.1 Function: MARKs phosphorilate and modulate tau, MAP2 and MAP4, major regulators of microtubule polymerization and organization within the cell.; Similarity: in particular it shows a strong similarity to MARK-1 and -2 of different mammals.; Similarity: the predicted ORF shows strong similarity and the typical domains of several known and putative protein Ser/Thr kinases.; Title: strong similarity to serine/threonine kinase MARK2 - Rattus norvegicus; See PMID 9108484; See PMID 10737602; uncharacterized protein 1437590 4990200 An18g06320 Aspergillus niger uncharacterized protein XP_059602997.1 1434932 R 5061 CDS An18g06330 84593767 join(1437610..1437641,1437800..1438000,1438089..1438143,1438311..1438375,1438450..1438488,1438632..1438776) VIII 1 NT_166533.1 Title: questionable ORF; uncharacterized protein 1438776 84593767 An18g06330 Aspergillus niger uncharacterized protein XP_059602998.1 1437610 D 5061 CDS An18g06340 4990202 complement(join(1440253..1440312,1440545..1440628,1440794..1440936,1441002..1441047,1441117..1441713)) VIII 1 NT_166533.1 Catalytic activity: 2 Geranylgeranyl diphosphate = Pyrophosphate + Prephytoene diphosphate.; Function: the R. norvegicus protein geranylgeranyltransferase type-I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a carboxyl-terminal CAAX (C, cysteine; A, aliphatic amino acid; X, any amino acid) motif in which the 'X' residue is leucine.; Remark: the co-expression of the GGTase-I beta subunit cDNA from R. norvegicus together with the alpha subunit of protein farnesyltransferase in E. coli produced recombinant GGTase-I with electrophoretic and enzymatic properties indistinguishable from native GGTase-I.; Title: strong similarity to geranylgeranyl diphosphate geranylgeranyltransferase I beta chain GGTase-I - Rattus norvegicus; See PMID 8106351; uncharacterized protein 1441713 4990202 An18g06340 Aspergillus niger uncharacterized protein XP_059602999.1 1440253 R 5061 CDS An18g06350 4990203 join(1442164..1442301,1442381..1442855,1442895..1442911) VIII 1 NT_166533.1 hypothetical protein 1442911 4990203 An18g06350 Aspergillus niger hypothetical protein XP_059603000.1 1442164 D 5061 CDS An18g06360 4990204 complement(join(1443253..1443629,1443740..1443872,1443941..1444027)) VIII 1 NT_166533.1 Induction: CSA1 from C. albicans is preferentially expressed during the mycelial growth phase, although a low level of CSA1 mRNA can be detected in the yeast form.; Localization: Csa1 from C. albicans is not randomly distributed over the surface of yeast cells, but localizes predominantly in the growing buds.; Similarity: the ORF also shows strong similarity to the EST an_2742 from Aspergillus niger.; Title: similarity to mycelial surface antigen Csa1 -Candida albicans; plasma membrane; See PMID 10652105; uncharacterized protein 1444027 4990204 An18g06360 Aspergillus niger uncharacterized protein XP_001399089.1 1443253 R 5061 CDS An18g06370 4990205 join(1444655..1444992,1445639..1445702,1445970..1446040,1446096..1446240,1446288..1446698,1446755..1447246,1447301..1447709,1447867..1447943) VIII 1 NT_166533.1 Function: Hol1 from S. cerevisiae is a member of the major facilitator transporter family.; Phenotype: mutations in the hol1 gene of S. cerevisiae permit growth of histidine auxotrophs cells on histidinol, the biosynthetic precursor to histidine, by enhancing the ability of cells to take up histidinol from the medium.; Remark: the synonym for Hol1 from S. cerevisiae is YNR055c.; Title: strong similarity to multidrug resistance protein Hol1 - Saccharomyces cerevisiae; See PMID 2405251; See PMID 8955402; uncharacterized protein 1447943 4990205 An18g06370 Aspergillus niger uncharacterized protein XP_059603001.1 1444655 D 5061 CDS An18g06380 4990206 complement(join(1448628..1448681,1448780..1449466)) VIII 1 NT_166533.1 Similarity: the ORF is much shorter than FmtB of S. aureus (246 compared to 1795 amino acids); the alignment between these two proteins encompasses only about 80 amino acids.; Title: weak similarity to protein involved in methicillin resistance FmtB - Staphylococcus aureus; See PMID 10896508; uncharacterized protein 1449466 4990206 An18g06380 Aspergillus niger uncharacterized protein XP_001399091.1 1448628 R 5061 CDS An18g06390 4990207 join(1450558..1450639,1450818..1450922,1451014..1452324,1452380..1453473) VIII 1 NT_166533.1 Similarity: the similarities to lower scored matches are mainly based on repetetive structures.; Title: strong similarity to hypothetical conserved protein encoded by B2F7.170 - Neurospora crassa; uncharacterized protein 1453473 4990207 An18g06390 Aspergillus niger uncharacterized protein XP_059605035.1 1450558 D 5061 CDS An18g06400 4990208 join(1454319..1454437,1454504..1454540,1454649..1454763,1454816..1455059,1455130..1455511,1455744..1455797) VIII 1 NT_166533.1 Title: weak similarity to protein-tyrosine phosphatase ptp - Clostridium perfringens; uncharacterized protein 1455797 4990208 An18g06400 Aspergillus niger uncharacterized protein XP_059605036.1 1454319 D 5061 CDS An18g06410 4990209 complement(join(1456109..1456323,1456382..1456587,1456646..1456915,1456987..1457068,1457134..1457188)) VIII 1 NT_166533.1 Title: strong similarity to hypothetical conserved protein encoded by B2F7.030 - Neurospora crassa; uncharacterized protein 1457188 4990209 An18g06410 Aspergillus niger uncharacterized protein XP_001399094.1 1456109 R 5061 CDS An18g06420 84593768 complement(join(1457402..1457554,1457637..1457750,1457823..1457907,1458003..1458067)) VIII 1 NT_166533.1 hypothetical protein 1458067 84593768 An18g06420 Aspergillus niger hypothetical protein XP_059605037.1 1457402 R 5061 CDS An18g06430 4990211 complement(1458373..1459308) VIII 1 NT_166533.1 Similarity: the similarities are mainly based on repetetive structures.; Title: weak similarity to chorion gene s18 -Ceratitis capitata; uncharacterized protein 1459308 4990211 An18g06430 Aspergillus niger uncharacterized protein XP_001399096.1 1458373 R 5061 CDS An18g06440 4990212 complement(1459530..1460051) VIII 1 NT_166533.1 Localization: Yip3 is selectively and efficiently packaged into COPII vesicles.; Remark: cytosolic coat proteins (COPII) direct the formation of transport vesicles.; Remark: the synonym for Yip3 from S. cerevisiae is YNL044w.; Title: strong similarity to COPII vesicle component Yip3 - Saccharomyces cerevisiae; intracellular transport vesicles; See PMID 11157978; uncharacterized protein 1460051 4990212 An18g06440 Aspergillus niger uncharacterized protein XP_001399097.1 1459530 R 5061 CDS An18g06450 84593769 join(1460226..1460471,1460513..1460583,1460662..1460728) VIII 1 NT_166533.1 Title: weak similarity to hypothetical protein L5515.05 - Leishmania major; uncharacterized protein 1460728 84593769 An18g06450 Aspergillus niger uncharacterized protein XP_059605038.1 1460226 D 5061 CDS An18g06460 84593770 complement(join(1460770..1460840,1460929..1460975,1461032..1461216)) VIII 1 NT_166533.1 Title: weak similarity to calcium channel BI-2 -Oryctolagus cuniculus; uncharacterized protein 1461216 84593770 An18g06460 Aspergillus niger uncharacterized protein XP_059605039.1 1460770 R 5061 CDS An18g06470 4990215 join(1461451..1461523,1461603..1461668,1461745..1462799) VIII 1 NT_166533.1 Function: Mtj1 from M. musculus stimulates the ATPase activity of the Hsp70 family member BiP/GRP78 at stoichiometric concentrations.; Induction: Mtj1 from M. musculus is enriched in the nuclear and heavy microsome subcellular fractions of murine tumor cells.; Title: strong similarity to DnaJ-like protein MTJ1 -Mus musculus; See PMID 10777498; See PMID 7875597; uncharacterized protein 1462799 4990215 An18g06470 Aspergillus niger uncharacterized protein XP_001399100.1 1461451 D 5061 CDS An18g06485 10098280 complement(join(1463576..1464084,1464227..1464266)) VIII 1 NT_166533.1 hypothetical protein 1464266 10098280 An18g06485 Aspergillus niger hypothetical protein XP_059605040.1 1463576 R 5061 CDS An18g06490 4990217 join(1464589..1464595,1464652..1464666,1464731..1464791,1464843..1465422) VIII 1 NT_166533.1 Induction: heat shock applied on C. curvatus for 1 h resulted in a pronounced but transient increase of the SIS1 mRNA.; Remark: Cryptococcus curvatus = Apiotrichum curvatum.; Remark: separated by a sucrose gradient Sis1 from C. curvatus was found in fractions together with ribosomes and with Hsp70.; Title: similarity to ribosome-associated DnaJ protein Sis1 - Cryptococcus curvatus; cytoplasm; See PMID 9559550; uncharacterized protein 1465422 4990217 An18g06490 Aspergillus niger uncharacterized protein XP_001399102.1 1464589 D 5061 CDS An18g06500 4990218 join(1465980..1466084,1466181..1466243,1466295..1466611,1466676..1466750,1466821..1467070) VIII 1 NT_166533.1 Catalytic activity: D-Mannose 1-phosphate = D-Mannose 6-phosphate.; Cofactor: D-Mannose 1,6-bisphosphate, D-Glucose 1,6-bisphosphate.; Function: Sec53 from S. cerevisiae is required for completion of assembly of proteins in the endoplasmic reticulum in yeast.; Function: Sec53 from S. cerevisiae is required for folding and glycosylation of secretory proteins in the lumen of the yeast endoplasmic reticulum.; Function: a sec53 mutant of S. cerevisiae is not defective in translocation, rather in assembly of the dolichol-oligosaccharide substrate needed for N-linked glycosylation.; Function: the secretory defect in phosphomannomutase sec53 cells of S. cerevisiae may be explained by a deficit in GDP-mannose production.; Localization: Sec53 protein from S. cerevisiae is associated with the cytoplasmic surface of the endoplasmic reticulum membrane.; Phenotype: precursors to exported proteins become firmly attached to the endoplasmic reticulum membrane and are not released into the lumen in a soluble form.; Remark: synonyms for Sec53 from S. cerevisiae are Alg4 and YFL045c.; Similarity: the ORF also shows strong similarity to the EST an_3165 from Aspergillus niger.; Title: strong similarity to phosphomannomutase Sec53 - Saccharomyces cerevisiae; endoplasmatic reticulum; See PMID 3046935; See PMID 3288631; See PMID 3298255; See PMID 3317409; uncharacterized protein 1467070 4990218 An18g06500 Aspergillus niger uncharacterized protein XP_001399103.1 1465980 D 5061 CDS An18g06510 4990219 join(1468055..1468088,1468154..1468335,1468410..1471641,1471707..1472164,1472228..1472779) VIII 1 NT_166533.1 Phenotype: a rad5 mutant of A. thaliana is blocked at a step in the transformation process prior to T-DNA integration following the transformation by Agrobacterium tumefaciens.; Phenotype: the Arabidopsis rad5 mutant is phenotypically similar to mutants in the RAD52 epistasis group of S. cerevisiae, which are highly sensitive to ionizing radiation but not hypersensitive to UV light.; Title: strong similarity to DNA repair protein RAD5 - Arabidopsis thaliana; nucleus; See PMID 9805401; See PMID 8028582; uncharacterized protein 1472779 4990219 An18g06510 Aspergillus niger uncharacterized protein XP_001399104.3 1468055 D 5061 CDS An18g06520 4990220 join(1473234..1478141,1478218..1478439,1478602..1478635,1478684..1479102,1479220..1479389,1479483..1479655,1479787..1479851,1480039..1480248) VIII 1 NT_166533.1 Function: Ecm29 from S. cerevisiae is involved in cell wall biogenesis and architecture.; Phenotype: the ecm29 mutant of S. cerevisiae is hypersensitive to calcofluor white and zymolyase but is resistant to hygromycin B.; Remark: the synonym for Ecm29 from S. cerevisiae is YHL030w.; Title: strong similarity to protein involved in cell wall biogenesis and architecture Ecm29 - Saccharomyces cerevisiae; See PMID 9335584; uncharacterized protein 1480248 4990220 An18g06520 Aspergillus niger uncharacterized protein XP_059605041.1 1473234 D 5061 CDS An18g06530 84593771 complement(join(1480529..1480675,1480726..1480830,1480948..1481008,1481134..1481208,1481420..1481469)) VIII 1 NT_166533.1 Title: weak similarity to beta V spectrin BSPECV -Homo sapiens; uncharacterized protein 1481469 84593771 An18g06530 Aspergillus niger uncharacterized protein XP_059605042.1 1480529 R 5061 CDS An18g06540 4990222 join(1481630..1481857,1481982..1482088,1482240..1482246,1482288..1482408,1482474..1483060,1483127..1483369,1483463..1483518,1483551..1483911,1483970..1484241,1484276..1484372) VIII 1 NT_166533.1 putative frameshift; hypothetical protein 1484372 4990222 An18g06540 Aspergillus niger hypothetical protein XP_059605043.1 1481630 D 5061 CDS An18g06550 84593772 complement(join(1484668..1484807,1484843..1484987,1485082..1485189,1485296..1485328)) VIII 1 NT_166533.1 hypothetical protein 1485328 84593772 An18g06550 Aspergillus niger hypothetical protein XP_059605044.1 1484668 R 5061 CDS An18g06560 84593773 1485371..>1486615 VIII 1 NT_166533.1 Remark: C-terminal truncated ORF due to end of contig.; Title: strong similarity to putative signalling cascade component protein pro40 - Sordaria macrospora [truncated ORF]; uncharacterized protein 1486615 84593773 An18g06560 Aspergillus niger uncharacterized protein XP_059605045.1 1485371 D 5061 CDS An18g06570 4990225 join(<1486718..1487694,1487747..1488353,1488418..1488957) VIII 1 NT_166533.1 Remark: the ORF is N-terminally truncated due to the contig border.; Remark: the ORF shows strong similarity to the hypothetical membrane protein YGR266w from S. cerevisiae but no transmembrane domain was predicted for the ORF.; Title: strong similarity to hypothetical protein YGR266w - Saccharomyces cerevisiae [truncated ORF]; See PMID 9605509; uncharacterized protein 1488957 4990225 An18g06570 Aspergillus niger uncharacterized protein XP_001399110.3 1486718 D 5061 CDS An18g06580 4990226 complement(join(1490286..1491257,1491311..1491580)) VIII 1 NT_166533.1 Phenotype: in a Y. lipolytica lip2 knockout (KO) strain no extracellular lipase activity was detected.; Similarity: the A. niger EST an_2774 in EMBLEST:BE759847 overlaps with the ORF.; Similarity: the ORF has a local N-terminal strong similarity to the lip2 protein of Y. lipolytica (ending at amino acid 306 of the ORF).; Similarity: the predicted ORF shows similarity to esterases of various Aspergillus species and with different cellular functions.; Title: strong similarity to triacylglycerol lipase Lip2 - Yarrowia lipolytica; See PMID 10781549; uncharacterized protein 1491580 4990226 An18g06580 Aspergillus niger uncharacterized protein XP_001399111.1 1490286 R 5061 CDS An18g06590 4990227 complement(join(1492042..1492082,1492141..1492381,1492452..1493038,1493099..1493321)) VIII 1 NT_166533.1 Complex: biochemical analyses demonstrate that sop2 protein of S. pombe is present in a complex which also contains the actin-related protein, Arp3p.; Function: sop2 protein of S. pombe modulates profilin and is part of a complex implicated in the control of actin polymerization.; Localization: immunofluorescence studies reveal the presence of sop2 protein of S. pombe in punctate structures distributed throughout the cell, cables that extend the length of the cell, and a medial band in a small percentage of septating cells.; Phenotype: S. pombe sop2 mutant is defective for cell elongation and septation.; Title: strong similarity to Arp2/3 complex subunit sop2p - Schizosaccharomyces pombe; uncharacterized protein 1493321 4990227 An18g06590 Aspergillus niger uncharacterized protein XP_001399112.1 1492042 R 5061 CDS An18g06600 4990228 join(1493809..1494042,1494100..1494399) VIII 1 NT_166533.1 Similarity: the ORF is C-terminally shorter than snRNP U2B'' of H. sapiens (47 amino acids).; Title: strong similarity to small nuclear ribonucleoprotein U2B snRNP U2B - Homo sapiens; See PMID 10648562; See PMID 2951739; uncharacterized protein 1494399 4990228 An18g06600 Aspergillus niger uncharacterized protein XP_001399113.3 1493809 D 5061 CDS An18g06610 4990229 complement(join(1494492..1494688,1494765..1494861,1494928..1495077)) VIII 1 NT_166533.1 hypothetical protein 1495077 4990229 An18g06610 Aspergillus niger hypothetical protein XP_059603002.1 1494492 R 5061 CDS An18g06620 84593774 complement(join(1495375..1495540,1495773..1495881,1495949..1496057,1496412..1496558,1496642..1496677)) VIII 1 NT_166533.1 Remark: unusual exon/intron structure for A. niger.; Title: questionable ORF; uncharacterized protein 1496677 84593774 An18g06620 Aspergillus niger uncharacterized protein XP_059603003.1 1495375 R 5061 CDS An18g06630 84593775 complement(join(1497304..1497483,1497514..1497667,1497744..1497787)) VIII 1 NT_166533.1 Remark: short length for A. niger ORFs (125 amino acids).; hypothetical protein 1497787 84593775 An18g06630 Aspergillus niger hypothetical protein XP_059603004.1 1497304 R 5061 CDS An18g06640 84593776 1498729..1500996 VIII 1 NT_166533.1 hypothetical protein 1500996 84593776 An18g06640 Aspergillus niger hypothetical protein XP_059603005.1 1498729 D 5061 CDS An18g06650 4990233 complement(1502821..1503402) VIII 1 NT_166533.1 Induction: Northern blot hybridization indicated that the expression of the hsp30 gene of A. nidulans was high at a normal temperature and was slightly accelerated at elevated temperatures in A. nidulans cells.; Title: strong similarity to heat shock protein hsp30 - Aspergillus nidulans; See PMID 7918658; See PMID 11482349; uncharacterized protein 1503402 4990233 An18g06650 Aspergillus niger uncharacterized protein XP_001399118.1 1502821 R 5061 CDS An18g06660 84593777 complement(join(1503946..1504069,1504270..1504379)) VIII 1 NT_166533.1 Title: strong similarity to hypothetical protein SPAC664.12c - Schizosaccharomyces pombe; uncharacterized protein 1504379 84593777 An18g06660 Aspergillus niger uncharacterized protein XP_059603006.1 1503946 R 5061 CDS An18g06670 4990235 join(1504854..1504868,1504936..1505657,1505717..1505849) VIII 1 NT_166533.1 Title: strong similarity to hypothetical 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase BH2000 -Bacillus halodurans; uncharacterized protein 1505849 4990235 An18g06670 Aspergillus niger uncharacterized protein XP_001399120.1 1504854 D 5061 CDS An18g06680 4990236 complement(join(1506083..1506687,1506753..1506900,1506959..1506988)) VIII 1 NT_166533.1 Catalytic activity: the PRE4 gene of S. cerevisiae is necessary for peptidylglutamyl-peptide-hydrolyzing activity.; Complex: PRE4 protein of S. cerevisiae is a subunit of the yeast proteasome, proteinase yscE.; Function: the PRE4 protein of S. cerevisiae is involved in ubiquitin-dependent protein degradation.; Phenotype: chromosomal deletion of the PRE4 gene of S. cerevisiae is lethal.; Phenotype: pre1-1 (mutation in the gene responsible for the chymotrypsin-like activity) and pre4-1 S. cerevisiae double mutants showed enhanced canavanine sensitivity and increased accumulation of ubiquitin protein conjugates, as compared with pre1-1 single mutants.; Title: strong similarity to proteasome 20S subunit Pre4 - Saccharomyces cerevisiae; See PMID 8381431; uncharacterized protein 1506988 4990236 An18g06680 Aspergillus niger uncharacterized protein XP_001399121.1 1506083 R 5061 CDS An18g06690 4990237 complement(join(1507665..1508245,1508313..1508361,1508415..1508489)) VIII 1 NT_166533.1 Similarity: the ORF is N-terminally longer than the hypothetical protein of S. pombe (70 amino acids).; Similarity: the ORF shows weak similarity to transcriptional regulator protein HCNGP of H. sapiens and M. musculus.; Title: similarity to hypothetical protein SPAC3H1.03 - Schizosaccharomyces pombe; uncharacterized protein 1508489 4990237 An18g06690 Aspergillus niger uncharacterized protein XP_059603007.1 1507665 R 5061 CDS An18g06700 4990238 join(1508890..1508984,1509041..1509728) VIII 1 NT_166533.1 Complex: the PRE7 protein of S. cerevisiae is a subunit of the 20S core proteasome.; Phenotype: chromosomal disruption of the PRE7 gene of S. cerevisiae creates a recessive lethal mutation.; Remark: PRE7 of S. cerevisiae is also called PTS1,YBL041W, YBL0407 or PRS3, which is now used for a ribose-phosphate pyrophosphokinase of S. cerevisiae.; Remark: the 20 S proteasome is the proteolytic core of the 26 S proteasome, the central protease involved in ubiquitin-mediated protein degradation in eukaryotes.; Similarity: the A. niger EST clone 2974 in EMBLEST:BE760015ORF overlaps with the ORF.; Title: strong similarity to proteasome 20S subunit Pre7 - Saccharomyces cerevisiae; See PMID 10500111; See PMID 1734860; uncharacterized protein 1509728 4990238 An18g06700 Aspergillus niger uncharacterized protein XP_001399123.1 1508890 D 5061 CDS An18g06710 4990239 complement(join(1509993..1510049,1510120..1510766,1510827..1510902)) VIII 1 NT_166533.1 Title: strong similarity to hypothetical protein YOR3513c - Saccharomyces cerevisiae; uncharacterized protein 1510902 4990239 An18g06710 Aspergillus niger uncharacterized protein XP_001399124.1 1509993 R 5061 CDS An18g06720 4990240 join(1511462..1512065,1512117..1513336,1513391..1513522) VIII 1 NT_166533.1 Title: strong similarity to hypothetical protein YHR194w - Saccharomyces cerevisiae; uncharacterized protein 1513522 4990240 An18g06720 Aspergillus niger uncharacterized protein XP_059603008.1 1511462 D 5061 CDS An18g06730 4990241 join(1514003..1514043,1514082..1514538,1514612..1518302,1518353..1519017) VIII 1 NT_166533.1 Remark: the putative A. niger protein is 1000 amino acids longer than human Rlip76.; Title: similarity to GTPase-activating protein RLIP76 - Homo sapiens; similarity: the putative A. niger protein shows similarity to different GTPase-activating proteins.; See PMID 7673236; uncharacterized protein 1519017 4990241 An18g06730 Aspergillus niger uncharacterized protein XP_059603009.1 1514003 D 5061 CDS An18g06740 4990242 complement(join(1519754..1520391,1520529..1520598)) VIII 1 NT_166533.1 Similarity: the A. niger ORF shows strong similarity to EST an_0449 of A. niger; Similarity: the A. niger portein also shows weak similarity to the rat steroidogenic acute regulatory protein.; Title: strong similarity to hypothetical protein YHR181w - Saccharomyces cerevisiae; uncharacterized protein 1520598 4990242 An18g06740 Aspergillus niger uncharacterized protein XP_001399127.1 1519754 R 5061 CDS An18g06750 4990243 join(1520907..1520929,1521002..1521818) VIII 1 NT_166533.1 Function: S-adenosyl-L-methyltransferases are involved in transferring methylgroups to a variety of target molecules.; Remark: the S-adenosyl-L-methyltransferase from patent US5876996-A is not properly described.; Title: strong similarity to S-adenosyl-L-methyltransferase from patent US5876996-A -Homo sapiens; uncharacterized protein 1521818 4990243 An18g06750 Aspergillus niger uncharacterized protein XP_001399128.1 1520907 D 5061 CDS An18g06760 4990244 complement(join(1522466..1522553,1522623..1523526,1523595..1523669,1523744..1523801,1524050..1524082)) VIII 1 NT_166533.1 Catalytic activity: isocitrate dehydrogenases catalyze the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.; Remark: Histoplasma capsulatum is an alternative name for A. capsulatus .; Remark: isocitrate dehydrogenase from S. cerevisiae is composed of two nonidentical subunits, IDH1 and IDH2.; Remark: isocitrate dehydrogenase subunit I from can rescue the idh1 mutant of S. cerevisiae.; Title: strong similarity to NAD(+)-isocitrate dehydrogenase subunit I idh1 - Ajellomyces capsulatus; localisation:mitochondrion; See PMID 10398348; uncharacterized protein 1524082 4990244 An18g06760 Aspergillus niger uncharacterized protein XP_001399129.1 1522466 R 5061 CDS An18g06770 84593778 1525370..1525696 VIII 1 NT_166533.1 hypothetical protein 1525696 84593778 An18g06770 Aspergillus niger hypothetical protein XP_059603010.1 1525370 D 5061 CDS An18g06780 4990246 complement(join(1526542..1527345,1527408..1527506)) VIII 1 NT_166533.1 Title: similarity to hypothetical protein B1O14.080 - Neurospora crassa; uncharacterized protein 1527506 4990246 An18g06780 Aspergillus niger uncharacterized protein XP_001399131.1 1526542 R 5061 CDS An18g06790 84593779 join(1527800..1527843,1527969..1528079,1528232..1528394) VIII 1 NT_166533.1 hypothetical protein 1528394 84593779 An18g06790 Aspergillus niger hypothetical protein XP_059603011.1 1527800 D 5061 CDS An18g06800 4990248 join(1528586..1528588,1528647..1528712,1528774..1528932,1529015..1529237,1529307..1529341,1529396..1529734) VIII 1 NT_166533.1 Complex: the PRE10 protein of S. cerevisiae is the alpha7 subunit of the 20S core proteasome.; Function: the 20 S proteasome is the proteolytic core of the 26 S proteasome, the central protease involved in ubiquitin-mediated protein degradation in eukaryotes.; Remark: PRS1, YC1 and PRC1 are alternative gene names for PRE10; Title: strong similarity to proteasome 20S subunit Pre10 - Saccharomyces cerevisiae; See PMID 1697860; uncharacterized protein 1529734 4990248 An18g06800 Aspergillus niger uncharacterized protein XP_059603012.1 1528586 D 5061 CDS An18g06810 4990249 complement(join(1530003..1530420,1530507..1530672,1530737..1530785)) VIII 1 NT_166533.1 Complex: RIB4 from S. cerevisiae forms a pentamer in vivo.; Pathway: RIB4 from S. cerevisiae is involved in the biosynthesis of riboflavin.; Phenotype: yeast rib4 mutants are auxotrophic for riboflavin.; Title: similarity to 6,7-dimethyl-8-ribityllumazine synthase Rib4 - Saccharomyces cerevisiae; See PMID 7559556; uncharacterized protein 1530785 4990249 An18g06810 Aspergillus niger uncharacterized protein XP_001399134.1 1530003 R 5061 CDS An18g06820 4990250 complement(join(1531322..1531542,1531597..1531758,1531812..1533205,1533277..1533508,1533600..1533670,1533729..1533733)) VIII 1 NT_166533.1 Catalytic activity: Gfa1p of S. cerevisiae catalyzes the formation of D-glucosamine-6-phosphate from the amido group of L-glutamine and fructose-6-phosphate: L-glutamine + D-fructose-6-phosphate <=> L-glutamate + D-glucosamine-6-phosphate.; Function: Gfa1p of S. cerevisiae is involved in the first step of the hexosamine pathway required for biosynthesis of cell wall precursors.; Induction: the glutamine--fructose-6-phosphate amidotransferase activity of gfa1 from S. cerevisiae increases 1. 7-fold after alpha factor addition.; Induction: the promotor region of the S. cerevisiae gfa1 gene contains six repeats of the heptanucleotide TGAAACA, which was shown to be required for pheromone control of transcription.; Remark: a splice site was detected upstream of the START codon.; Remark: glucosamine-6-phosphate is used in the biosynthesis of amino sugars of asparagine-linked oligosaccharide chains in glycoproteins.; Title: strong similarity to glutamine-fructose-6-phosphate transaminase Gfa1 -Saccharomyces cerevisiae; cytoplasm; See PMID 2656689; uncharacterized protein 1533733 4990250 An18g06820 Aspergillus niger uncharacterized protein XP_001399135.1 1531322 R 5061 CDS An18g06830 84593780 join(1534051..1534177,1534274..1534317) VIII 1 NT_166533.1 Title: questionable ORF; uncharacterized protein 1534317 84593780 An18g06830 Aspergillus niger uncharacterized protein XP_059603013.1 1534051 D 5061 CDS An18g06840 4990252 join(1537225..1537467,1537582..1538978,1539018..1539628,1539884..1540294,1540367..1540840,1540896..1540999) VIII 1 NT_166533.1 Phenotype: mutant human trithorax leads to leukemia.; Similarity: the A. niger protein also shows similarity to other trithorax like proteins.; Title: similarity to trithorax protein All1 - Homo sapiens; nucleus; See PMID 1303259; See PMID 1423624; uncharacterized protein 1540999 4990252 An18g06840 Aspergillus niger uncharacterized protein XP_059603014.1 1537225 D 5061 CDS An18g06850 4990253 complement(join(1541521..1541733,1541805..1541990)) VIII 1 NT_166533.1 Remark: the A. niger protein also shows similarity to human prostate tumor EST fragment derived protein #79 from patent DE19820190-A1. The function of this protein has not been described.; Title: strong similarity to hypothetical conserved protein SPAC31A2.02 - Schizosaccharomyces pombe; uncharacterized protein 1541990 4990253 An18g06850 Aspergillus niger uncharacterized protein XP_001399138.1 1541521 R 5061 CDS