-- dump date 20140620_084610 -- class Genbank::misc_feature -- table misc_feature_note -- id note 697283000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 697283000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697283000003 Walker A motif; other site 697283000004 ATP binding site [chemical binding]; other site 697283000005 Walker B motif; other site 697283000006 arginine finger; other site 697283000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 697283000008 DnaA box-binding interface [nucleotide binding]; other site 697283000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 697283000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 697283000011 putative DNA binding surface [nucleotide binding]; other site 697283000012 dimer interface [polypeptide binding]; other site 697283000013 beta-clamp/clamp loader binding surface; other site 697283000014 beta-clamp/translesion DNA polymerase binding surface; other site 697283000015 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 697283000016 GTP-binding protein YchF; Reviewed; Region: PRK09601 697283000017 YchF GTPase; Region: YchF; cd01900 697283000018 G1 box; other site 697283000019 GTP/Mg2+ binding site [chemical binding]; other site 697283000020 Switch I region; other site 697283000021 G2 box; other site 697283000022 Switch II region; other site 697283000023 G3 box; other site 697283000024 G4 box; other site 697283000025 G5 box; other site 697283000026 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 697283000027 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 697283000028 putative active site [active] 697283000029 catalytic residue [active] 697283000030 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 697283000031 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 697283000032 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 697283000033 ATP binding site [chemical binding]; other site 697283000034 putative Mg++ binding site [ion binding]; other site 697283000035 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 697283000036 nucleotide binding region [chemical binding]; other site 697283000037 ATP-binding site [chemical binding]; other site 697283000038 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 697283000039 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 697283000040 RNA binding surface [nucleotide binding]; other site 697283000041 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 697283000042 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 697283000043 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 697283000044 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 697283000045 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 697283000046 Ligand Binding Site [chemical binding]; other site 697283000047 TilS substrate C-terminal domain; Region: TilS_C; smart00977 697283000048 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 697283000049 active site 697283000050 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 697283000051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697283000052 Walker A motif; other site 697283000053 ATP binding site [chemical binding]; other site 697283000054 Walker B motif; other site 697283000055 arginine finger; other site 697283000056 Peptidase family M41; Region: Peptidase_M41; pfam01434 697283000057 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 697283000058 Helix-turn-helix domain; Region: HTH_28; pfam13518 697283000059 Winged helix-turn helix; Region: HTH_29; pfam13551 697283000060 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 697283000061 DDE superfamily endonuclease; Region: DDE_3; pfam13358 697283000062 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 697283000063 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 697283000064 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 697283000065 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 697283000066 GDP-binding site [chemical binding]; other site 697283000067 ACT binding site; other site 697283000068 IMP binding site; other site 697283000069 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 697283000070 active site 697283000071 catalytic residues [active] 697283000072 DNA binding site [nucleotide binding] 697283000073 Int/Topo IB signature motif; other site 697283000074 HIRAN domain; Region: HIRAN; pfam08797 697283000075 Domain of unknown function (DUF955); Region: DUF955; cl01076 697283000076 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 697283000077 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 697283000078 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697283000079 non-specific DNA binding site [nucleotide binding]; other site 697283000080 salt bridge; other site 697283000081 sequence-specific DNA binding site [nucleotide binding]; other site 697283000082 Prophage antirepressor [Transcription]; Region: COG3617 697283000083 BRO family, N-terminal domain; Region: Bro-N; smart01040 697283000084 ORF6C domain; Region: ORF6C; pfam10552 697283000085 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889 697283000086 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 697283000087 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697283000088 Walker A motif; other site 697283000089 ATP binding site [chemical binding]; other site 697283000090 Walker B motif; other site 697283000091 arginine finger; other site 697283000092 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 697283000093 YopX protein; Region: YopX; cl09859 697283000094 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 697283000095 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 697283000096 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 697283000097 Int/Topo IB signature motif; other site 697283000098 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 697283000099 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 697283000100 ATP binding site [chemical binding]; other site 697283000101 putative Mg++ binding site [ion binding]; other site 697283000102 Phage-related protein [Function unknown]; Region: COG4695; cl01923 697283000103 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 697283000104 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 697283000105 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 697283000106 Phage capsid family; Region: Phage_capsid; pfam05065 697283000107 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 697283000108 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 697283000109 Phage-related minor tail protein [Function unknown]; Region: COG5280 697283000110 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 697283000111 membrane protein P6; Region: PHA01399 697283000112 Phage-related minor tail protein [Function unknown]; Region: COG5281 697283000113 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 697283000114 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 697283000115 toxin secretion/phage lysis holin; Region: holin_tox_secr; TIGR01593 697283000116 Phage holin protein (Holin_LLH); Region: Holin_LLH; cl09890 697283000117 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 697283000118 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 697283000119 amidase catalytic site [active] 697283000120 Zn binding residues [ion binding]; other site 697283000121 substrate binding site [chemical binding]; other site 697283000122 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 697283000123 nucleoside/Zn binding site; other site 697283000124 dimer interface [polypeptide binding]; other site 697283000125 catalytic motif [active] 697283000126 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 697283000127 trimer interface [polypeptide binding]; other site 697283000128 active site 697283000129 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 697283000130 catalytic core [active] 697283000131 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 697283000132 DNA repair protein RadA; Provisional; Region: PRK11823 697283000133 Walker A motif; other site 697283000134 ATP binding site [chemical binding]; other site 697283000135 Walker B motif; other site 697283000136 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 697283000137 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 697283000138 active site clefts [active] 697283000139 zinc binding site [ion binding]; other site 697283000140 dimer interface [polypeptide binding]; other site 697283000141 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 697283000142 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 697283000143 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 697283000144 active site 697283000145 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 697283000146 DNA polymerase I; Provisional; Region: PRK05755 697283000147 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 697283000148 active site 697283000149 metal binding site 1 [ion binding]; metal-binding site 697283000150 putative 5' ssDNA interaction site; other site 697283000151 metal binding site 3; metal-binding site 697283000152 metal binding site 2 [ion binding]; metal-binding site 697283000153 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 697283000154 putative DNA binding site [nucleotide binding]; other site 697283000155 putative metal binding site [ion binding]; other site 697283000156 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 697283000157 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 697283000158 active site 697283000159 DNA binding site [nucleotide binding] 697283000160 catalytic site [active] 697283000161 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 697283000162 Predicted membrane protein [Function unknown]; Region: COG2855 697283000163 aromatic amino acid aminotransferase; Validated; Region: PRK07309 697283000164 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 697283000165 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697283000166 homodimer interface [polypeptide binding]; other site 697283000167 catalytic residue [active] 697283000168 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 697283000169 Recombination protein O N terminal; Region: RecO_N; pfam11967 697283000170 Recombination protein O C terminal; Region: RecO_C; pfam02565 697283000171 putative phosphate acyltransferase; Provisional; Region: PRK05331 697283000172 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 697283000173 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 697283000174 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 697283000175 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 697283000176 putative active site [active] 697283000177 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 697283000178 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697283000179 Walker A/P-loop; other site 697283000180 ATP binding site [chemical binding]; other site 697283000181 Q-loop/lid; other site 697283000182 ABC transporter signature motif; other site 697283000183 Walker B; other site 697283000184 D-loop; other site 697283000185 H-loop/switch region; other site 697283000186 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 697283000187 HlyD family secretion protein; Region: HlyD_3; pfam13437 697283000188 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 697283000189 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 697283000190 ATP binding site [chemical binding]; other site 697283000191 active site 697283000192 substrate binding site [chemical binding]; other site 697283000193 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 697283000194 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 697283000195 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 697283000196 dimerization interface [polypeptide binding]; other site 697283000197 ATP binding site [chemical binding]; other site 697283000198 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 697283000199 dimerization interface [polypeptide binding]; other site 697283000200 ATP binding site [chemical binding]; other site 697283000201 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 697283000202 putative active site [active] 697283000203 catalytic triad [active] 697283000204 amidophosphoribosyltransferase; Provisional; Region: PRK07272 697283000205 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 697283000206 active site 697283000207 tetramer interface [polypeptide binding]; other site 697283000208 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 697283000209 active site 697283000210 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 697283000211 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 697283000212 dimerization interface [polypeptide binding]; other site 697283000213 putative ATP binding site [chemical binding]; other site 697283000214 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 697283000215 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 697283000216 active site 697283000217 substrate binding site [chemical binding]; other site 697283000218 cosubstrate binding site; other site 697283000219 catalytic site [active] 697283000220 VanZ like family; Region: VanZ; pfam04892 697283000221 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 697283000222 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 697283000223 purine monophosphate binding site [chemical binding]; other site 697283000224 dimer interface [polypeptide binding]; other site 697283000225 putative catalytic residues [active] 697283000226 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 697283000227 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 697283000228 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 697283000229 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 697283000230 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 697283000231 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 697283000232 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 697283000233 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 697283000234 ATP-grasp domain; Region: ATP-grasp; pfam02222 697283000235 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 697283000236 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 697283000237 tetramer interface [polypeptide binding]; other site 697283000238 active site 697283000239 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 697283000240 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 697283000241 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 697283000242 active site 697283000243 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 697283000244 active site 697283000245 G5 domain; Region: G5; pfam07501 697283000246 G5 domain; Region: G5; pfam07501 697283000247 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 697283000248 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 697283000249 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 697283000250 DNA-binding site [nucleotide binding]; DNA binding site 697283000251 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 697283000252 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 697283000253 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 697283000254 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 697283000255 active site 697283000256 phosphorylation site [posttranslational modification] 697283000257 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 697283000258 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 697283000259 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 697283000260 active pocket/dimerization site; other site 697283000261 active site 697283000262 phosphorylation site [posttranslational modification] 697283000263 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 697283000264 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 697283000265 dimer interface [polypeptide binding]; other site 697283000266 active site 697283000267 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 697283000268 putative active site [active] 697283000269 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 697283000270 active site 697283000271 catalytic residues [active] 697283000272 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 697283000273 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 697283000274 putative metal binding site [ion binding]; other site 697283000275 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 697283000276 active site 697283000277 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 697283000278 putative homodimer interface [polypeptide binding]; other site 697283000279 putative homotetramer interface [polypeptide binding]; other site 697283000280 putative metal binding site [ion binding]; other site 697283000281 putative homodimer-homodimer interface [polypeptide binding]; other site 697283000282 putative allosteric switch controlling residues; other site 697283000283 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 697283000284 active site residue [active] 697283000285 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 697283000286 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 697283000287 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 697283000288 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 697283000289 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 697283000290 TrkA-N domain; Region: TrkA_N; pfam02254 697283000291 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 697283000292 active site 697283000293 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 697283000294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697283000295 active site 697283000296 phosphorylation site [posttranslational modification] 697283000297 intermolecular recognition site; other site 697283000298 dimerization interface [polypeptide binding]; other site 697283000299 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 697283000300 DNA binding site [nucleotide binding] 697283000301 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 697283000302 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 697283000303 dimerization interface [polypeptide binding]; other site 697283000304 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 697283000305 dimer interface [polypeptide binding]; other site 697283000306 phosphorylation site [posttranslational modification] 697283000307 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697283000308 ATP binding site [chemical binding]; other site 697283000309 Mg2+ binding site [ion binding]; other site 697283000310 G-X-G motif; other site 697283000311 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 697283000312 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 697283000313 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 697283000314 RNA binding surface [nucleotide binding]; other site 697283000315 Helix-turn-helix domain; Region: HTH_28; pfam13518 697283000316 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 697283000317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283000318 dimer interface [polypeptide binding]; other site 697283000319 conserved gate region; other site 697283000320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 697283000321 ABC-ATPase subunit interface; other site 697283000322 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 697283000323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283000324 dimer interface [polypeptide binding]; other site 697283000325 conserved gate region; other site 697283000326 putative PBP binding loops; other site 697283000327 ABC-ATPase subunit interface; other site 697283000328 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 697283000329 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 697283000330 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 697283000331 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 697283000332 active site residue [active] 697283000333 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 697283000334 Domain of unknown function (DUF4299); Region: DUF4299; pfam14132 697283000335 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 697283000336 Predicted membrane protein [Function unknown]; Region: COG4709 697283000337 Predicted transcriptional regulators [Transcription]; Region: COG1695 697283000338 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 697283000339 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 697283000340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697283000341 putative substrate translocation pore; other site 697283000342 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 697283000343 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 697283000344 Ligand binding site; other site 697283000345 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 697283000346 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 697283000347 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 697283000348 NAD(P) binding site [chemical binding]; other site 697283000349 homodimer interface [polypeptide binding]; other site 697283000350 substrate binding site [chemical binding]; other site 697283000351 active site 697283000352 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 697283000353 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697283000354 active site 697283000355 motif I; other site 697283000356 motif II; other site 697283000357 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 697283000358 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 697283000359 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 697283000360 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 697283000361 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 697283000362 putative L-serine binding site [chemical binding]; other site 697283000363 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 697283000364 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 697283000365 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; pfam09683 697283000366 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 697283000367 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 697283000368 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 697283000369 Walker A/P-loop; other site 697283000370 ATP binding site [chemical binding]; other site 697283000371 Q-loop/lid; other site 697283000372 ABC transporter signature motif; other site 697283000373 Walker B; other site 697283000374 D-loop; other site 697283000375 H-loop/switch region; other site 697283000376 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 697283000377 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 697283000378 substrate binding pocket [chemical binding]; other site 697283000379 membrane-bound complex binding site; other site 697283000380 hinge residues; other site 697283000381 Arginosuccinate synthase; Region: Arginosuc_synth; cl17227 697283000382 Leucine-zipper of ternary complex factor MIP1; Region: Lzipper-MIP1; pfam14389 697283000383 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 697283000384 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 697283000385 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 697283000386 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 697283000387 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 697283000388 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 697283000389 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 697283000390 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 697283000391 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 697283000392 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 697283000393 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 697283000394 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 697283000395 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 697283000396 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 697283000397 nudix motif; other site 697283000398 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 697283000399 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 697283000400 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 697283000401 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 697283000402 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 697283000403 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 697283000404 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 697283000405 hypothetical protein; Provisional; Region: PRK13667 697283000406 class IIb bacteriocin, lactobin A/cerein 7B family; Region: bact_IIb_cerein; TIGR03949 697283000407 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 697283000408 Glycoprotease family; Region: Peptidase_M22; pfam00814 697283000409 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 697283000410 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697283000411 Coenzyme A binding pocket [chemical binding]; other site 697283000412 UGMP family protein; Validated; Region: PRK09604 697283000413 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 697283000414 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 697283000415 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 697283000416 Transposase; Region: DDE_Tnp_ISL3; pfam01610 697283000417 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 697283000418 Transposase; Region: DDE_Tnp_ISL3; pfam01610 697283000419 Winged helix-turn helix; Region: HTH_33; pfam13592 697283000420 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 697283000421 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 697283000422 active site 697283000423 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 697283000424 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 697283000425 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 697283000426 Walker A/P-loop; other site 697283000427 ATP binding site [chemical binding]; other site 697283000428 Q-loop/lid; other site 697283000429 ABC transporter signature motif; other site 697283000430 Walker B; other site 697283000431 D-loop; other site 697283000432 H-loop/switch region; other site 697283000433 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 697283000434 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 697283000435 Ligand Binding Site [chemical binding]; other site 697283000436 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 697283000437 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 697283000438 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 697283000439 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 697283000440 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697283000441 non-specific DNA binding site [nucleotide binding]; other site 697283000442 salt bridge; other site 697283000443 sequence-specific DNA binding site [nucleotide binding]; other site 697283000444 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 697283000445 CAAX protease self-immunity; Region: Abi; pfam02517 697283000446 CAAX protease self-immunity; Region: Abi; pfam02517 697283000447 AzlC protein; Region: AzlC; cl00570 697283000448 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 697283000449 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 697283000450 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 697283000451 substrate binding pocket [chemical binding]; other site 697283000452 membrane-bound complex binding site; other site 697283000453 hinge residues; other site 697283000454 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 697283000455 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 697283000456 hypothetical protein; Provisional; Region: PRK06446 697283000457 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 697283000458 metal binding site [ion binding]; metal-binding site 697283000459 dimer interface [polypeptide binding]; other site 697283000460 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 697283000461 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 697283000462 Walker A/P-loop; other site 697283000463 ATP binding site [chemical binding]; other site 697283000464 Q-loop/lid; other site 697283000465 ABC transporter signature motif; other site 697283000466 Walker B; other site 697283000467 D-loop; other site 697283000468 H-loop/switch region; other site 697283000469 NIL domain; Region: NIL; pfam09383 697283000470 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 697283000471 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 697283000472 Predicted integral membrane protein [Function unknown]; Region: COG5578 697283000473 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 697283000474 HAMP domain; Region: HAMP; pfam00672 697283000475 Histidine kinase; Region: His_kinase; pfam06580 697283000476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697283000477 ATP binding site [chemical binding]; other site 697283000478 Mg2+ binding site [ion binding]; other site 697283000479 G-X-G motif; other site 697283000480 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 697283000481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697283000482 active site 697283000483 phosphorylation site [posttranslational modification] 697283000484 intermolecular recognition site; other site 697283000485 dimerization interface [polypeptide binding]; other site 697283000486 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 697283000487 flavoprotein NrdI; Provisional; Region: PRK02551 697283000488 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 697283000489 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 697283000490 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 697283000491 LytTr DNA-binding domain; Region: LytTR; smart00850 697283000492 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 697283000493 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697283000494 ATP binding site [chemical binding]; other site 697283000495 Mg2+ binding site [ion binding]; other site 697283000496 G-X-G motif; other site 697283000497 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 697283000498 ATP binding site [chemical binding]; other site 697283000499 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 697283000500 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 697283000501 homopentamer interface [polypeptide binding]; other site 697283000502 active site 697283000503 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 697283000504 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 697283000505 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 697283000506 dimerization interface [polypeptide binding]; other site 697283000507 active site 697283000508 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 697283000509 Lumazine binding domain; Region: Lum_binding; pfam00677 697283000510 Lumazine binding domain; Region: Lum_binding; pfam00677 697283000511 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 697283000512 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 697283000513 catalytic motif [active] 697283000514 Zn binding site [ion binding]; other site 697283000515 RibD C-terminal domain; Region: RibD_C; cl17279 697283000516 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 697283000517 RuvA N terminal domain; Region: RuvA_N; pfam01330 697283000518 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 697283000519 CAAX protease self-immunity; Region: Abi; pfam02517 697283000520 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 697283000521 putative dimer interface [polypeptide binding]; other site 697283000522 catalytic triad [active] 697283000523 Uncharacterized membrane-bound protein conserved in bacteria [Function unknown]; Region: COG4858 697283000524 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 697283000525 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 697283000526 Cl binding site [ion binding]; other site 697283000527 oligomer interface [polypeptide binding]; other site 697283000528 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 697283000529 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 697283000530 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 697283000531 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 697283000532 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 697283000533 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 697283000534 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 697283000535 active site 697283000536 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 697283000537 ArsC family; Region: ArsC; pfam03960 697283000538 putative catalytic residues [active] 697283000539 thiol/disulfide switch; other site 697283000540 hypothetical protein; Provisional; Region: PRK05473 697283000541 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 697283000542 hypothetical protein; Provisional; Region: PRK13678 697283000543 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 697283000544 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 697283000545 Bacterial lipoprotein; Region: DUF3642; pfam12182 697283000546 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 697283000547 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 697283000548 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 697283000549 putative active site [active] 697283000550 catalytic site [active] 697283000551 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 697283000552 putative active site [active] 697283000553 catalytic site [active] 697283000554 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 697283000555 ATP cone domain; Region: ATP-cone; pfam03477 697283000556 Class III ribonucleotide reductase; Region: RNR_III; cd01675 697283000557 effector binding site; other site 697283000558 active site 697283000559 Zn binding site [ion binding]; other site 697283000560 glycine loop; other site 697283000561 Predicted acetyltransferase [General function prediction only]; Region: COG3981 697283000562 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 697283000563 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 697283000564 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697283000565 FeS/SAM binding site; other site 697283000566 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 697283000567 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 697283000568 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 697283000569 active site 697283000570 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 697283000571 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 697283000572 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 697283000573 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 697283000574 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 697283000575 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 697283000576 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 697283000577 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 697283000578 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 697283000579 putative translocon binding site; other site 697283000580 protein-rRNA interface [nucleotide binding]; other site 697283000581 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 697283000582 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 697283000583 G-X-X-G motif; other site 697283000584 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 697283000585 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 697283000586 23S rRNA interface [nucleotide binding]; other site 697283000587 5S rRNA interface [nucleotide binding]; other site 697283000588 putative antibiotic binding site [chemical binding]; other site 697283000589 L25 interface [polypeptide binding]; other site 697283000590 L27 interface [polypeptide binding]; other site 697283000591 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 697283000592 23S rRNA interface [nucleotide binding]; other site 697283000593 putative translocon interaction site; other site 697283000594 signal recognition particle (SRP54) interaction site; other site 697283000595 L23 interface [polypeptide binding]; other site 697283000596 trigger factor interaction site; other site 697283000597 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 697283000598 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 697283000599 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 697283000600 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 697283000601 RNA binding site [nucleotide binding]; other site 697283000602 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 697283000603 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 697283000604 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 697283000605 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 697283000606 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 697283000607 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 697283000608 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 697283000609 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 697283000610 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 697283000611 5S rRNA interface [nucleotide binding]; other site 697283000612 L27 interface [polypeptide binding]; other site 697283000613 23S rRNA interface [nucleotide binding]; other site 697283000614 L5 interface [polypeptide binding]; other site 697283000615 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 697283000616 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 697283000617 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 697283000618 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 697283000619 23S rRNA binding site [nucleotide binding]; other site 697283000620 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 697283000621 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 697283000622 SecY translocase; Region: SecY; pfam00344 697283000623 adenylate kinase; Reviewed; Region: adk; PRK00279 697283000624 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 697283000625 AMP-binding site [chemical binding]; other site 697283000626 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 697283000627 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 697283000628 rRNA binding site [nucleotide binding]; other site 697283000629 predicted 30S ribosome binding site; other site 697283000630 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 697283000631 30S ribosomal protein S13; Region: bact_S13; TIGR03631 697283000632 30S ribosomal protein S11; Validated; Region: PRK05309 697283000633 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 697283000634 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 697283000635 alphaNTD homodimer interface [polypeptide binding]; other site 697283000636 alphaNTD - beta interaction site [polypeptide binding]; other site 697283000637 alphaNTD - beta' interaction site [polypeptide binding]; other site 697283000638 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 697283000639 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 697283000640 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 697283000641 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 697283000642 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 697283000643 catalytic core [active] 697283000644 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 697283000645 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 697283000646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283000647 dimer interface [polypeptide binding]; other site 697283000648 conserved gate region; other site 697283000649 putative PBP binding loops; other site 697283000650 ABC-ATPase subunit interface; other site 697283000651 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 697283000652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283000653 dimer interface [polypeptide binding]; other site 697283000654 conserved gate region; other site 697283000655 ABC-ATPase subunit interface; other site 697283000656 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 697283000657 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 697283000658 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 697283000659 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 697283000660 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 697283000661 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 697283000662 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 697283000663 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 697283000664 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 697283000665 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 697283000666 active site 697283000667 methionine cluster; other site 697283000668 phosphorylation site [posttranslational modification] 697283000669 metal binding site [ion binding]; metal-binding site 697283000670 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 697283000671 active site 697283000672 P-loop; other site 697283000673 phosphorylation site [posttranslational modification] 697283000674 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 697283000675 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 697283000676 Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882 697283000677 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 697283000678 dimer interface [polypeptide binding]; other site 697283000679 active site 697283000680 glycine loop; other site 697283000681 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 697283000682 active site 697283000683 intersubunit interactions; other site 697283000684 catalytic residue [active] 697283000685 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 697283000686 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 697283000687 dimer interface [polypeptide binding]; other site 697283000688 active site 697283000689 metal binding site [ion binding]; metal-binding site 697283000690 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 697283000691 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 697283000692 HIGH motif; other site 697283000693 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 697283000694 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 697283000695 active site 697283000696 KMSKS motif; other site 697283000697 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 697283000698 tRNA binding surface [nucleotide binding]; other site 697283000699 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 697283000700 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 697283000701 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 697283000702 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697283000703 Coenzyme A binding pocket [chemical binding]; other site 697283000704 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 697283000705 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697283000706 Walker A motif; other site 697283000707 ATP binding site [chemical binding]; other site 697283000708 Walker B motif; other site 697283000709 arginine finger; other site 697283000710 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 697283000711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575 697283000712 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 697283000713 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 697283000714 catalytic residue [active] 697283000715 putative FPP diphosphate binding site; other site 697283000716 putative FPP binding hydrophobic cleft; other site 697283000717 dimer interface [polypeptide binding]; other site 697283000718 putative IPP diphosphate binding site; other site 697283000719 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 697283000720 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 697283000721 RIP metalloprotease RseP; Region: TIGR00054 697283000722 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 697283000723 active site 697283000724 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 697283000725 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 697283000726 putative substrate binding region [chemical binding]; other site 697283000727 prolyl-tRNA synthetase; Provisional; Region: PRK09194 697283000728 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 697283000729 dimer interface [polypeptide binding]; other site 697283000730 motif 1; other site 697283000731 active site 697283000732 motif 2; other site 697283000733 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 697283000734 putative deacylase active site [active] 697283000735 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 697283000736 active site 697283000737 motif 3; other site 697283000738 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 697283000739 anticodon binding site; other site 697283000740 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 697283000741 beta-galactosidase; Region: BGL; TIGR03356 697283000742 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 697283000743 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 697283000744 glutaminase active site [active] 697283000745 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 697283000746 dimer interface [polypeptide binding]; other site 697283000747 active site 697283000748 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 697283000749 dimer interface [polypeptide binding]; other site 697283000750 active site 697283000751 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 697283000752 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 697283000753 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 697283000754 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 697283000755 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 697283000756 carbohydrate binding site [chemical binding]; other site 697283000757 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 697283000758 carbohydrate binding site [chemical binding]; other site 697283000759 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 697283000760 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 697283000761 Ca binding site [ion binding]; other site 697283000762 active site 697283000763 catalytic site [active] 697283000764 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 697283000765 S17 interaction site [polypeptide binding]; other site 697283000766 S8 interaction site; other site 697283000767 16S rRNA interaction site [nucleotide binding]; other site 697283000768 streptomycin interaction site [chemical binding]; other site 697283000769 23S rRNA interaction site [nucleotide binding]; other site 697283000770 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 697283000771 30S ribosomal protein S7; Validated; Region: PRK05302 697283000772 elongation factor G; Reviewed; Region: PRK00007 697283000773 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 697283000774 G1 box; other site 697283000775 putative GEF interaction site [polypeptide binding]; other site 697283000776 GTP/Mg2+ binding site [chemical binding]; other site 697283000777 Switch I region; other site 697283000778 G2 box; other site 697283000779 G3 box; other site 697283000780 Switch II region; other site 697283000781 G4 box; other site 697283000782 G5 box; other site 697283000783 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 697283000784 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 697283000785 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 697283000786 DNA polymerase III PolC; Validated; Region: polC; PRK00448 697283000787 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 697283000788 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 697283000789 generic binding surface II; other site 697283000790 generic binding surface I; other site 697283000791 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 697283000792 active site 697283000793 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 697283000794 active site 697283000795 catalytic site [active] 697283000796 substrate binding site [chemical binding]; other site 697283000797 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 697283000798 putative PHP Thumb interface [polypeptide binding]; other site 697283000799 active site 697283000800 addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384 697283000801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 697283000802 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 697283000803 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 697283000804 Predicted membrane protein [Function unknown]; Region: COG2261 697283000805 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 697283000806 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 697283000807 RNA binding surface [nucleotide binding]; other site 697283000808 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 697283000809 active site 697283000810 uracil binding [chemical binding]; other site 697283000811 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 697283000812 trimer interface [polypeptide binding]; other site 697283000813 active site 697283000814 G bulge; other site 697283000815 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 697283000816 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 697283000817 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 697283000818 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 697283000819 active pocket/dimerization site; other site 697283000820 active site 697283000821 phosphorylation site [posttranslational modification] 697283000822 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 697283000823 active site 697283000824 phosphorylation site [posttranslational modification] 697283000825 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 697283000826 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 697283000827 NAD binding site [chemical binding]; other site 697283000828 substrate binding site [chemical binding]; other site 697283000829 catalytic Zn binding site [ion binding]; other site 697283000830 tetramer interface [polypeptide binding]; other site 697283000831 structural Zn binding site [ion binding]; other site 697283000832 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 697283000833 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697283000834 active site 697283000835 motif I; other site 697283000836 motif II; other site 697283000837 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 697283000838 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 697283000839 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 697283000840 dihydropteroate synthase; Region: DHPS; TIGR01496 697283000841 substrate binding pocket [chemical binding]; other site 697283000842 dimer interface [polypeptide binding]; other site 697283000843 inhibitor binding site; inhibition site 697283000844 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 697283000845 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 697283000846 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 697283000847 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 697283000848 homodecamer interface [polypeptide binding]; other site 697283000849 GTP cyclohydrolase I; Provisional; Region: PLN03044 697283000850 active site 697283000851 putative catalytic site residues [active] 697283000852 zinc binding site [ion binding]; other site 697283000853 GTP-CH-I/GFRP interaction surface; other site 697283000854 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 697283000855 homooctamer interface [polypeptide binding]; other site 697283000856 active site 697283000857 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 697283000858 catalytic center binding site [active] 697283000859 ATP binding site [chemical binding]; other site 697283000860 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 697283000861 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 697283000862 23S rRNA interface [nucleotide binding]; other site 697283000863 L3 interface [polypeptide binding]; other site 697283000864 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 697283000865 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 697283000866 DDE superfamily endonuclease; Region: DDE_3; pfam13358 697283000867 Uncharacterized conserved protein [Function unknown]; Region: COG1359 697283000868 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 697283000869 beta-galactosidase; Region: BGL; TIGR03356 697283000870 Uncharacterized conserved protein [Function unknown]; Region: COG4095 697283000871 cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590 697283000872 active site 697283000873 P-loop; other site 697283000874 phosphorylation site [posttranslational modification] 697283000875 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 697283000876 HTH domain; Region: HTH_11; pfam08279 697283000877 Mga helix-turn-helix domain; Region: Mga; pfam05043 697283000878 PRD domain; Region: PRD; pfam00874 697283000879 PRD domain; Region: PRD; pfam00874 697283000880 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 697283000881 active site 697283000882 P-loop; other site 697283000883 phosphorylation site [posttranslational modification] 697283000884 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 697283000885 active site 697283000886 phosphorylation site [posttranslational modification] 697283000887 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 697283000888 methionine cluster; other site 697283000889 active site 697283000890 phosphorylation site [posttranslational modification] 697283000891 metal binding site [ion binding]; metal-binding site 697283000892 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 697283000893 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 697283000894 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 697283000895 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 697283000896 putative active site [active] 697283000897 putative catalytic site [active] 697283000898 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 697283000899 catalytic residues [active] 697283000900 dimer interface [polypeptide binding]; other site 697283000901 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 697283000902 substrate binding site [chemical binding]; other site 697283000903 catalytic residues [active] 697283000904 Transposase IS200 like; Region: Y1_Tnp; pfam01797 697283000905 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 697283000906 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 697283000907 active site 697283000908 intersubunit interface [polypeptide binding]; other site 697283000909 catalytic residue [active] 697283000910 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 697283000911 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 697283000912 substrate binding site [chemical binding]; other site 697283000913 ATP binding site [chemical binding]; other site 697283000914 hypothetical protein; Provisional; Region: PRK09273 697283000915 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 697283000916 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 697283000917 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 697283000918 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 697283000919 NADP binding site [chemical binding]; other site 697283000920 homodimer interface [polypeptide binding]; other site 697283000921 active site 697283000922 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 697283000923 active pocket/dimerization site; other site 697283000924 active site 697283000925 phosphorylation site [posttranslational modification] 697283000926 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 697283000927 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 697283000928 active site 697283000929 phosphorylation site [posttranslational modification] 697283000930 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 697283000931 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 697283000932 Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862 697283000933 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 697283000934 Transcriptional regulators [Transcription]; Region: PurR; COG1609 697283000935 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 697283000936 DNA binding site [nucleotide binding] 697283000937 domain linker motif; other site 697283000938 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 697283000939 putative dimerization interface [polypeptide binding]; other site 697283000940 putative ligand binding site [chemical binding]; other site 697283000941 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 697283000942 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697283000943 non-specific DNA binding site [nucleotide binding]; other site 697283000944 salt bridge; other site 697283000945 sequence-specific DNA binding site [nucleotide binding]; other site 697283000946 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 697283000947 MraW methylase family; Region: Methyltransf_5; pfam01795 697283000948 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 697283000949 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 697283000950 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 697283000951 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 697283000952 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 697283000953 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 697283000954 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 697283000955 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 697283000956 Mg++ binding site [ion binding]; other site 697283000957 putative catalytic motif [active] 697283000958 putative substrate binding site [chemical binding]; other site 697283000959 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697283000960 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 697283000961 Walker A motif; other site 697283000962 ATP binding site [chemical binding]; other site 697283000963 Walker B motif; other site 697283000964 arginine finger; other site 697283000965 UvrB/uvrC motif; Region: UVR; pfam02151 697283000966 MoxR-like ATPases [General function prediction only]; Region: COG0714 697283000967 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697283000968 Walker A motif; other site 697283000969 ATP binding site [chemical binding]; other site 697283000970 Walker B motif; other site 697283000971 arginine finger; other site 697283000972 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 697283000973 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 697283000974 LuxS protein involved in autoinducer AI2 synthesis [Signal transduction mechanisms]; Region: LuxS; COG1854 697283000975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 697283000976 hypothetical protein; Provisional; Region: PRK13663 697283000977 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 697283000978 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 697283000979 Ca binding site [ion binding]; other site 697283000980 active site 697283000981 catalytic site [active] 697283000982 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 697283000983 Transposase; Region: DDE_Tnp_ISL3; pfam01610 697283000984 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 697283000985 Transposase; Region: DDE_Tnp_ISL3; pfam01610 697283000986 DDE superfamily endonuclease; Region: DDE_3; pfam13358 697283000987 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 697283000988 Transposase; Region: HTH_Tnp_IS630; pfam01710 697283000989 Helix-turn-helix domain; Region: HTH_28; pfam13518 697283000990 DNA polymerase processivity factor; Region: DNA_PPF; pfam02916 697283000991 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 697283000992 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 697283000993 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 697283000994 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 697283000995 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 697283000996 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 697283000997 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 697283000998 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 697283000999 putative ADP-binding pocket [chemical binding]; other site 697283001000 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 697283001001 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 697283001002 trimer interface [polypeptide binding]; other site 697283001003 active site 697283001004 substrate binding site [chemical binding]; other site 697283001005 CoA binding site [chemical binding]; other site 697283001006 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 697283001007 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 697283001008 O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296 697283001009 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 697283001010 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 697283001011 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 697283001012 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697283001013 NAD(P) binding site [chemical binding]; other site 697283001014 active site 697283001015 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 697283001016 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 697283001017 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 697283001018 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 697283001019 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 697283001020 Transposase; Region: DDE_Tnp_ISL3; pfam01610 697283001021 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 697283001022 Transposase; Region: DDE_Tnp_ISL3; pfam01610 697283001023 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 697283001024 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 697283001025 substrate binding site; other site 697283001026 tetramer interface; other site 697283001027 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 697283001028 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 697283001029 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 697283001030 NAD binding site [chemical binding]; other site 697283001031 substrate binding site [chemical binding]; other site 697283001032 homodimer interface [polypeptide binding]; other site 697283001033 active site 697283001034 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 697283001035 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 697283001036 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 697283001037 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 697283001038 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 697283001039 peptide binding site [polypeptide binding]; other site 697283001040 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 697283001041 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 697283001042 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 697283001043 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 697283001044 Transglycosylase; Region: Transgly; pfam00912 697283001045 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 697283001046 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 697283001047 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 697283001048 hypothetical protein; Provisional; Region: PRK13660 697283001049 cell division protein GpsB; Provisional; Region: PRK14127 697283001050 DivIVA domain; Region: DivI1A_domain; TIGR03544 697283001051 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 697283001052 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 697283001053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 697283001054 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 697283001055 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 697283001056 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 697283001057 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 697283001058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697283001059 active site 697283001060 phosphorylation site [posttranslational modification] 697283001061 intermolecular recognition site; other site 697283001062 dimerization interface [polypeptide binding]; other site 697283001063 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 697283001064 DNA binding site [nucleotide binding] 697283001065 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 697283001066 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 697283001067 active site 697283001068 zinc binding site [ion binding]; other site 697283001069 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 697283001070 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 697283001071 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 697283001072 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 697283001073 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 697283001074 diphosphomevalonate decarboxylase; Region: PLN02407 697283001075 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 697283001076 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 697283001077 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 697283001078 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 697283001079 homotetramer interface [polypeptide binding]; other site 697283001080 FMN binding site [chemical binding]; other site 697283001081 homodimer contacts [polypeptide binding]; other site 697283001082 putative active site [active] 697283001083 putative substrate binding site [chemical binding]; other site 697283001084 Predicted membrane protein [Function unknown]; Region: COG4758 697283001085 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 697283001086 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 697283001087 Histidine kinase; Region: HisKA_3; pfam07730 697283001088 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697283001089 ATP binding site [chemical binding]; other site 697283001090 Mg2+ binding site [ion binding]; other site 697283001091 G-X-G motif; other site 697283001092 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 697283001093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697283001094 active site 697283001095 phosphorylation site [posttranslational modification] 697283001096 intermolecular recognition site; other site 697283001097 dimerization interface [polypeptide binding]; other site 697283001098 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 697283001099 DNA binding residues [nucleotide binding] 697283001100 dimerization interface [polypeptide binding]; other site 697283001101 A new structural DNA glycosylase; Region: AlkD_like; cl11434 697283001102 A new structural DNA glycosylase; Region: AlkD_like; cl11434 697283001103 A new structural DNA glycosylase; Region: AlkD_like; cl11434 697283001104 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 697283001105 active site 697283001106 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 697283001107 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 697283001108 DNA binding site [nucleotide binding] 697283001109 Int/Topo IB signature motif; other site 697283001110 active site 697283001111 trigger factor; Provisional; Region: tig; PRK01490 697283001112 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 697283001113 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 697283001114 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 697283001115 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 697283001116 DNA binding site [nucleotide binding] 697283001117 AAA domain; Region: AAA_30; pfam13604 697283001118 Family description; Region: UvrD_C_2; pfam13538 697283001119 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 697283001120 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 697283001121 Catalytic site [active] 697283001122 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 697283001123 ribonuclease HIII; Provisional; Region: PRK00996 697283001124 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 697283001125 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 697283001126 RNA/DNA hybrid binding site [nucleotide binding]; other site 697283001127 active site 697283001128 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 697283001129 Colicin V production protein; Region: Colicin_V; pfam02674 697283001130 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193 697283001131 MutS domain III; Region: MutS_III; pfam05192 697283001132 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 697283001133 Walker A/P-loop; other site 697283001134 ATP binding site [chemical binding]; other site 697283001135 Q-loop/lid; other site 697283001136 ABC transporter signature motif; other site 697283001137 Walker B; other site 697283001138 D-loop; other site 697283001139 H-loop/switch region; other site 697283001140 Smr domain; Region: Smr; pfam01713 697283001141 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 697283001142 amino acid carrier protein; Region: agcS; TIGR00835 697283001143 Uncharacterized conserved protein [Function unknown]; Region: COG2128 697283001144 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 697283001145 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 697283001146 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 697283001147 gating phenylalanine in ion channel; other site 697283001148 seryl-tRNA synthetase; Provisional; Region: PRK05431 697283001149 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 697283001150 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 697283001151 dimer interface [polypeptide binding]; other site 697283001152 active site 697283001153 motif 1; other site 697283001154 motif 2; other site 697283001155 motif 3; other site 697283001156 T-box leader 697283001157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4687 697283001158 aspartate kinase; Reviewed; Region: PRK09034 697283001159 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 697283001160 putative catalytic residues [active] 697283001161 putative nucleotide binding site [chemical binding]; other site 697283001162 putative aspartate binding site [chemical binding]; other site 697283001163 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 697283001164 allosteric regulatory residue; other site 697283001165 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 697283001166 enoyl-CoA hydratase; Provisional; Region: PRK07260 697283001167 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 697283001168 substrate binding site [chemical binding]; other site 697283001169 oxyanion hole (OAH) forming residues; other site 697283001170 trimer interface [polypeptide binding]; other site 697283001171 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 697283001172 MarR family; Region: MarR_2; pfam12802 697283001173 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 697283001174 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 697283001175 dimer interface [polypeptide binding]; other site 697283001176 active site 697283001177 CoA binding pocket [chemical binding]; other site 697283001178 acyl carrier protein; Provisional; Region: acpP; PRK00982 697283001179 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 697283001180 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 697283001181 FMN binding site [chemical binding]; other site 697283001182 substrate binding site [chemical binding]; other site 697283001183 putative catalytic residue [active] 697283001184 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 697283001185 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 697283001186 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 697283001187 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 697283001188 NAD(P) binding site [chemical binding]; other site 697283001189 homotetramer interface [polypeptide binding]; other site 697283001190 homodimer interface [polypeptide binding]; other site 697283001191 active site 697283001192 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 697283001193 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 697283001194 dimer interface [polypeptide binding]; other site 697283001195 active site 697283001196 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 697283001197 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 697283001198 carboxyltransferase (CT) interaction site; other site 697283001199 biotinylation site [posttranslational modification]; other site 697283001200 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 697283001201 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 697283001202 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 697283001203 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 697283001204 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 697283001205 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 697283001206 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 697283001207 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 697283001208 acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319 697283001209 CAAX protease self-immunity; Region: Abi; pfam02517 697283001210 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 697283001211 putative RNA binding site [nucleotide binding]; other site 697283001212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 697283001213 elongation factor P; Validated; Region: PRK00529 697283001214 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 697283001215 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 697283001216 RNA binding site [nucleotide binding]; other site 697283001217 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 697283001218 RNA binding site [nucleotide binding]; other site 697283001219 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 697283001220 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 697283001221 GatB domain; Region: GatB_Yqey; pfam02637 697283001222 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 697283001223 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 697283001224 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 697283001225 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 697283001226 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 697283001227 G1 box; other site 697283001228 putative GEF interaction site [polypeptide binding]; other site 697283001229 GTP/Mg2+ binding site [chemical binding]; other site 697283001230 Switch I region; other site 697283001231 G2 box; other site 697283001232 G3 box; other site 697283001233 Switch II region; other site 697283001234 G4 box; other site 697283001235 G5 box; other site 697283001236 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 697283001237 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 697283001238 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 697283001239 active site 697283001240 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 697283001241 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 697283001242 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 697283001243 DAK2 domain; Region: Dak2; pfam02734 697283001244 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282 697283001245 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 697283001246 PYR/PP interface [polypeptide binding]; other site 697283001247 dimer interface [polypeptide binding]; other site 697283001248 TPP binding site [chemical binding]; other site 697283001249 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 697283001250 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 697283001251 TPP-binding site [chemical binding]; other site 697283001252 dimer interface [polypeptide binding]; other site 697283001253 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 697283001254 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 697283001255 putative valine binding site [chemical binding]; other site 697283001256 dimer interface [polypeptide binding]; other site 697283001257 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 697283001258 ketol-acid reductoisomerase; Provisional; Region: PRK05479 697283001259 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 697283001260 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 697283001261 threonine dehydratase; Validated; Region: PRK08639 697283001262 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 697283001263 tetramer interface [polypeptide binding]; other site 697283001264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697283001265 catalytic residue [active] 697283001266 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 697283001267 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 697283001268 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697283001269 Walker A/P-loop; other site 697283001270 ATP binding site [chemical binding]; other site 697283001271 Q-loop/lid; other site 697283001272 ABC transporter signature motif; other site 697283001273 Walker B; other site 697283001274 D-loop; other site 697283001275 H-loop/switch region; other site 697283001276 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 697283001277 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 697283001278 substrate binding pocket [chemical binding]; other site 697283001279 membrane-bound complex binding site; other site 697283001280 hinge residues; other site 697283001281 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283001282 dimer interface [polypeptide binding]; other site 697283001283 conserved gate region; other site 697283001284 putative PBP binding loops; other site 697283001285 ABC-ATPase subunit interface; other site 697283001286 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 697283001287 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 697283001288 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 697283001289 Transposase; Region: DEDD_Tnp_IS110; pfam01548 697283001290 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 697283001291 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 697283001292 active site 697283001293 DNA polymerase IV; Validated; Region: PRK02406 697283001294 DNA binding site [nucleotide binding] 697283001295 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 697283001296 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 697283001297 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 697283001298 Transcriptional regulators [Transcription]; Region: MarR; COG1846 697283001299 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 697283001300 non-specific DNA interactions [nucleotide binding]; other site 697283001301 DNA binding site [nucleotide binding] 697283001302 sequence specific DNA binding site [nucleotide binding]; other site 697283001303 putative cAMP binding site [chemical binding]; other site 697283001304 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 697283001305 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 697283001306 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 697283001307 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 697283001308 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 697283001309 methionine cluster; other site 697283001310 active site 697283001311 phosphorylation site [posttranslational modification] 697283001312 metal binding site [ion binding]; metal-binding site 697283001313 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 697283001314 beta-galactosidase; Region: BGL; TIGR03356 697283001315 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 697283001316 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 697283001317 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 697283001318 active site 697283001319 P-loop; other site 697283001320 phosphorylation site [posttranslational modification] 697283001321 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 697283001322 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 697283001323 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 697283001324 TrkA-N domain; Region: TrkA_N; pfam02254 697283001325 TrkA-C domain; Region: TrkA_C; pfam02080 697283001326 TrkA-N domain; Region: TrkA_N; pfam02254 697283001327 TrkA-C domain; Region: TrkA_C; pfam02080 697283001328 Uncharacterized conserved protein [Function unknown]; Region: COG1912 697283001329 hypothetical protein; Provisional; Region: PRK13661 697283001330 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 697283001331 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 697283001332 Walker A/P-loop; other site 697283001333 ATP binding site [chemical binding]; other site 697283001334 Q-loop/lid; other site 697283001335 ABC transporter signature motif; other site 697283001336 Walker B; other site 697283001337 D-loop; other site 697283001338 H-loop/switch region; other site 697283001339 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 697283001340 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 697283001341 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 697283001342 Walker A/P-loop; other site 697283001343 ATP binding site [chemical binding]; other site 697283001344 Q-loop/lid; other site 697283001345 ABC transporter signature motif; other site 697283001346 Walker B; other site 697283001347 D-loop; other site 697283001348 H-loop/switch region; other site 697283001349 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 697283001350 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 697283001351 Predicted membrane protein [Function unknown]; Region: COG3601 697283001352 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 697283001353 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 697283001354 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 697283001355 active site 697283001356 ParB-like nuclease domain; Region: ParBc; cl02129 697283001357 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 697283001358 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 697283001359 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 697283001360 CTP synthetase; Validated; Region: pyrG; PRK05380 697283001361 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 697283001362 Catalytic site [active] 697283001363 active site 697283001364 UTP binding site [chemical binding]; other site 697283001365 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 697283001366 active site 697283001367 putative oxyanion hole; other site 697283001368 catalytic triad [active] 697283001369 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 697283001370 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 697283001371 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 697283001372 PhoU domain; Region: PhoU; pfam01895 697283001373 PhoU domain; Region: PhoU; pfam01895 697283001374 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 697283001375 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547 697283001376 putative active site [active] 697283001377 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 697283001378 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 697283001379 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 697283001380 G5 domain; Region: G5; pfam07501 697283001381 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 697283001382 Phosphoglycerate kinase; Region: PGK; pfam00162 697283001383 substrate binding site [chemical binding]; other site 697283001384 hinge regions; other site 697283001385 ADP binding site [chemical binding]; other site 697283001386 catalytic site [active] 697283001387 Predicted membrane protein [Function unknown]; Region: COG4129 697283001388 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 697283001389 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 697283001390 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 697283001391 DNA binding residues [nucleotide binding] 697283001392 putative dimer interface [polypeptide binding]; other site 697283001393 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 697283001394 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 697283001395 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 697283001396 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 697283001397 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 697283001398 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 697283001399 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 697283001400 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 697283001401 VanD integrase, IntD, and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases including those similar to IntD, a putative integrase-like protein, a component...; Region: INT_VanD; cd01196 697283001402 Int/Topo IB signature motif; other site 697283001403 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 697283001404 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 697283001405 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 697283001406 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 697283001407 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 697283001408 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 697283001409 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 697283001410 HsdM N-terminal domain; Region: HsdM_N; pfam12161 697283001411 Methyltransferase domain; Region: Methyltransf_26; pfam13659 697283001412 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 697283001413 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 697283001414 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 697283001415 ATP binding site [chemical binding]; other site 697283001416 putative Mg++ binding site [ion binding]; other site 697283001417 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 697283001418 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 697283001419 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 697283001420 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 697283001421 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 697283001422 dimer interface [polypeptide binding]; other site 697283001423 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 697283001424 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 697283001425 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 697283001426 nucleotide binding site [chemical binding]; other site 697283001427 NEF interaction site [polypeptide binding]; other site 697283001428 SBD interface [polypeptide binding]; other site 697283001429 chaperone protein DnaJ; Provisional; Region: PRK14276 697283001430 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 697283001431 HSP70 interaction site [polypeptide binding]; other site 697283001432 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 697283001433 substrate binding site [polypeptide binding]; other site 697283001434 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 697283001435 Zn binding sites [ion binding]; other site 697283001436 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 697283001437 substrate binding site [polypeptide binding]; other site 697283001438 dimer interface [polypeptide binding]; other site 697283001439 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 697283001440 HIT family signature motif; other site 697283001441 catalytic residue [active] 697283001442 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 697283001443 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 697283001444 Walker A/P-loop; other site 697283001445 ATP binding site [chemical binding]; other site 697283001446 Q-loop/lid; other site 697283001447 ABC transporter signature motif; other site 697283001448 Walker B; other site 697283001449 D-loop; other site 697283001450 H-loop/switch region; other site 697283001451 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 697283001452 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 697283001453 LytTr DNA-binding domain; Region: LytTR; pfam04397 697283001454 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 697283001455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697283001456 active site 697283001457 phosphorylation site [posttranslational modification] 697283001458 intermolecular recognition site; other site 697283001459 dimerization interface [polypeptide binding]; other site 697283001460 LytTr DNA-binding domain; Region: LytTR; pfam04397 697283001461 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 697283001462 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697283001463 ATP binding site [chemical binding]; other site 697283001464 Mg2+ binding site [ion binding]; other site 697283001465 G-X-G motif; other site 697283001466 COMC family; Region: ComC; pfam03047 697283001467 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 697283001468 HlyD family secretion protein; Region: HlyD_3; pfam13437 697283001469 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 697283001470 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 697283001471 putative active site [active] 697283001472 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 697283001473 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697283001474 Walker A/P-loop; other site 697283001475 ATP binding site [chemical binding]; other site 697283001476 Q-loop/lid; other site 697283001477 ABC transporter signature motif; other site 697283001478 Walker B; other site 697283001479 D-loop; other site 697283001480 H-loop/switch region; other site 697283001481 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 697283001482 CAAX protease self-immunity; Region: Abi; pfam02517 697283001483 CAAX protease self-immunity; Region: Abi; pfam02517 697283001484 Phosphotransferase enzyme family; Region: APH; pfam01636 697283001485 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 697283001486 substrate binding site [chemical binding]; other site 697283001487 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697283001488 S-adenosylmethionine binding site [chemical binding]; other site 697283001489 ribosome maturation protein RimP; Reviewed; Region: PRK00092 697283001490 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 697283001491 putative oligomer interface [polypeptide binding]; other site 697283001492 putative RNA binding site [nucleotide binding]; other site 697283001493 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 697283001494 NusA N-terminal domain; Region: NusA_N; pfam08529 697283001495 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 697283001496 RNA binding site [nucleotide binding]; other site 697283001497 homodimer interface [polypeptide binding]; other site 697283001498 NusA-like KH domain; Region: KH_5; pfam13184 697283001499 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 697283001500 G-X-X-G motif; other site 697283001501 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 697283001502 putative RNA binding cleft [nucleotide binding]; other site 697283001503 hypothetical protein; Provisional; Region: PRK07283 697283001504 translation initiation factor IF-2; Region: IF-2; TIGR00487 697283001505 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 697283001506 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 697283001507 G1 box; other site 697283001508 putative GEF interaction site [polypeptide binding]; other site 697283001509 GTP/Mg2+ binding site [chemical binding]; other site 697283001510 Switch I region; other site 697283001511 G2 box; other site 697283001512 G3 box; other site 697283001513 Switch II region; other site 697283001514 G4 box; other site 697283001515 G5 box; other site 697283001516 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 697283001517 Translation-initiation factor 2; Region: IF-2; pfam11987 697283001518 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 697283001519 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 697283001520 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 697283001521 Uncharacterized conserved protein [Function unknown]; Region: COG2461 697283001522 Family of unknown function (DUF438); Region: DUF438; pfam04282 697283001523 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 697283001524 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 697283001525 putative active site [active] 697283001526 heme pocket [chemical binding]; other site 697283001527 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 697283001528 hypothetical protein; Provisional; Region: PRK07758 697283001529 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 697283001530 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 697283001531 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 697283001532 AAA domain; Region: AAA_18; pfam13238 697283001533 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 697283001534 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 697283001535 active site 697283001536 HIGH motif; other site 697283001537 nucleotide binding site [chemical binding]; other site 697283001538 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 697283001539 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 697283001540 active site 697283001541 KMSKS motif; other site 697283001542 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 697283001543 tRNA binding surface [nucleotide binding]; other site 697283001544 anticodon binding site; other site 697283001545 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 697283001546 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 697283001547 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 697283001548 Fic/DOC family; Region: Fic; pfam02661 697283001549 Integrase core domain; Region: rve; pfam00665 697283001550 Integrase core domain; Region: rve_2; pfam13333 697283001551 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697283001552 Helix-turn-helix domain; Region: HTH_28; pfam13518 697283001553 Transposase; Region: HTH_Tnp_1; cl17663 697283001554 HTH-like domain; Region: HTH_21; pfam13276 697283001555 transcriptional antiterminator BglG; Provisional; Region: PRK09772 697283001556 CAT RNA binding domain; Region: CAT_RBD; smart01061 697283001557 PRD domain; Region: PRD; pfam00874 697283001558 PRD domain; Region: PRD; pfam00874 697283001559 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 697283001560 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 697283001561 active site turn [active] 697283001562 phosphorylation site [posttranslational modification] 697283001563 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 697283001564 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 697283001565 HPr interaction site; other site 697283001566 glycerol kinase (GK) interaction site [polypeptide binding]; other site 697283001567 active site 697283001568 phosphorylation site [posttranslational modification] 697283001569 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 697283001570 beta-galactosidase; Region: BGL; TIGR03356 697283001571 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 697283001572 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 697283001573 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 697283001574 dimer interface [polypeptide binding]; other site 697283001575 motif 1; other site 697283001576 active site 697283001577 motif 2; other site 697283001578 motif 3; other site 697283001579 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 697283001580 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697283001581 Coenzyme A binding pocket [chemical binding]; other site 697283001582 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 697283001583 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 697283001584 putative tRNA-binding site [nucleotide binding]; other site 697283001585 B3/4 domain; Region: B3_4; pfam03483 697283001586 tRNA synthetase B5 domain; Region: B5; smart00874 697283001587 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 697283001588 dimer interface [polypeptide binding]; other site 697283001589 motif 1; other site 697283001590 motif 3; other site 697283001591 motif 2; other site 697283001592 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 697283001593 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 697283001594 putative catalytic site [active] 697283001595 putative metal binding site [ion binding]; other site 697283001596 putative phosphate binding site [ion binding]; other site 697283001597 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 697283001598 Helix-turn-helix domain; Region: HTH_38; pfam13936 697283001599 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 697283001600 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697283001601 non-specific DNA binding site [nucleotide binding]; other site 697283001602 salt bridge; other site 697283001603 sequence-specific DNA binding site [nucleotide binding]; other site 697283001604 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 697283001605 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 697283001606 THF binding site; other site 697283001607 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 697283001608 substrate binding site [chemical binding]; other site 697283001609 THF binding site; other site 697283001610 zinc-binding site [ion binding]; other site 697283001611 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 697283001612 FAD binding site [chemical binding]; other site 697283001613 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 697283001614 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 697283001615 RNase E interface [polypeptide binding]; other site 697283001616 trimer interface [polypeptide binding]; other site 697283001617 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 697283001618 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 697283001619 RNase E interface [polypeptide binding]; other site 697283001620 trimer interface [polypeptide binding]; other site 697283001621 active site 697283001622 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 697283001623 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 697283001624 RNA binding site [nucleotide binding]; other site 697283001625 domain interface; other site 697283001626 serine O-acetyltransferase; Region: cysE; TIGR01172 697283001627 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 697283001628 trimer interface [polypeptide binding]; other site 697283001629 active site 697283001630 substrate binding site [chemical binding]; other site 697283001631 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697283001632 Coenzyme A binding pocket [chemical binding]; other site 697283001633 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 697283001634 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697283001635 Coenzyme A binding pocket [chemical binding]; other site 697283001636 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 697283001637 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 697283001638 active site 697283001639 HIGH motif; other site 697283001640 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 697283001641 KMSKS motif; other site 697283001642 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 697283001643 tRNA binding surface [nucleotide binding]; other site 697283001644 anticodon binding site; other site 697283001645 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 697283001646 active site 697283001647 metal binding site [ion binding]; metal-binding site 697283001648 dimerization interface [polypeptide binding]; other site 697283001649 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 697283001650 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 697283001651 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 697283001652 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 697283001653 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 697283001654 FtsX-like permease family; Region: FtsX; pfam02687 697283001655 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 697283001656 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 697283001657 Walker A/P-loop; other site 697283001658 ATP binding site [chemical binding]; other site 697283001659 Q-loop/lid; other site 697283001660 ABC transporter signature motif; other site 697283001661 Walker B; other site 697283001662 D-loop; other site 697283001663 H-loop/switch region; other site 697283001664 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 697283001665 FtsX-like permease family; Region: FtsX; pfam02687 697283001666 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 697283001667 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697283001668 active site 697283001669 phosphorylation site [posttranslational modification] 697283001670 intermolecular recognition site; other site 697283001671 dimerization interface [polypeptide binding]; other site 697283001672 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 697283001673 DNA binding site [nucleotide binding] 697283001674 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 697283001675 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 697283001676 dimerization interface [polypeptide binding]; other site 697283001677 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 697283001678 dimer interface [polypeptide binding]; other site 697283001679 phosphorylation site [posttranslational modification] 697283001680 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697283001681 ATP binding site [chemical binding]; other site 697283001682 Mg2+ binding site [ion binding]; other site 697283001683 G-X-G motif; other site 697283001684 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 697283001685 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 697283001686 intersubunit interface [polypeptide binding]; other site 697283001687 active site 697283001688 zinc binding site [ion binding]; other site 697283001689 Na+ binding site [ion binding]; other site 697283001690 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 697283001691 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 697283001692 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 697283001693 FAD binding pocket [chemical binding]; other site 697283001694 FAD binding motif [chemical binding]; other site 697283001695 phosphate binding motif [ion binding]; other site 697283001696 beta-alpha-beta structure motif; other site 697283001697 NAD binding pocket [chemical binding]; other site 697283001698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283001699 dimer interface [polypeptide binding]; other site 697283001700 conserved gate region; other site 697283001701 putative PBP binding loops; other site 697283001702 ABC-ATPase subunit interface; other site 697283001703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283001704 dimer interface [polypeptide binding]; other site 697283001705 conserved gate region; other site 697283001706 putative PBP binding loops; other site 697283001707 ABC-ATPase subunit interface; other site 697283001708 bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917 697283001709 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 697283001710 substrate binding pocket [chemical binding]; other site 697283001711 membrane-bound complex binding site; other site 697283001712 hinge residues; other site 697283001713 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 697283001714 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 697283001715 Walker A/P-loop; other site 697283001716 ATP binding site [chemical binding]; other site 697283001717 Q-loop/lid; other site 697283001718 ABC transporter signature motif; other site 697283001719 Walker B; other site 697283001720 D-loop; other site 697283001721 H-loop/switch region; other site 697283001722 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 697283001723 DHH family; Region: DHH; pfam01368 697283001724 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 697283001725 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 697283001726 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 697283001727 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 697283001728 Predicted esterase [General function prediction only]; Region: COG0627 697283001729 S-formylglutathione hydrolase; Region: PLN02442 697283001730 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 697283001731 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 697283001732 FemAB family; Region: FemAB; pfam02388 697283001733 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 697283001734 active site 697283001735 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 697283001736 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 697283001737 GIY-YIG motif/motif A; other site 697283001738 active site 697283001739 catalytic site [active] 697283001740 putative DNA binding site [nucleotide binding]; other site 697283001741 metal binding site [ion binding]; metal-binding site 697283001742 UvrB/uvrC motif; Region: UVR; pfam02151 697283001743 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 697283001744 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 697283001745 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 697283001746 active site 697283001747 metal binding site [ion binding]; metal-binding site 697283001748 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 697283001749 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 697283001750 substrate binding pocket [chemical binding]; other site 697283001751 membrane-bound complex binding site; other site 697283001752 hinge residues; other site 697283001753 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 697283001754 dimer interface [polypeptide binding]; other site 697283001755 FMN binding site [chemical binding]; other site 697283001756 dipeptidase PepV; Reviewed; Region: PRK07318 697283001757 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 697283001758 active site 697283001759 metal binding site [ion binding]; metal-binding site 697283001760 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 697283001761 putative uracil binding site [chemical binding]; other site 697283001762 putative active site [active] 697283001763 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 697283001764 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 697283001765 active site residue [active] 697283001766 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 697283001767 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 697283001768 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 697283001769 putative oligomer interface [polypeptide binding]; other site 697283001770 putative active site [active] 697283001771 metal binding site [ion binding]; metal-binding site 697283001772 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 697283001773 nucleotide binding site/active site [active] 697283001774 HIT family signature motif; other site 697283001775 catalytic residue [active] 697283001776 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 697283001777 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 697283001778 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 697283001779 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 697283001780 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 697283001781 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 697283001782 23S rRNA interface [nucleotide binding]; other site 697283001783 L7/L12 interface [polypeptide binding]; other site 697283001784 putative thiostrepton binding site; other site 697283001785 L25 interface [polypeptide binding]; other site 697283001786 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 697283001787 mRNA/rRNA interface [nucleotide binding]; other site 697283001788 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 697283001789 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697283001790 Walker A/P-loop; other site 697283001791 ATP binding site [chemical binding]; other site 697283001792 Q-loop/lid; other site 697283001793 ABC transporter signature motif; other site 697283001794 Walker B; other site 697283001795 D-loop; other site 697283001796 H-loop/switch region; other site 697283001797 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 697283001798 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 697283001799 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694 697283001800 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 697283001801 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 697283001802 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 697283001803 putative active site [active] 697283001804 catalytic triad [active] 697283001805 PA_2: Protease-associated (PA) domain subgroup 2. A subgroup of PA-domain containing proteins. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is...; Region: PA_2; cd04819 697283001806 PA/protease or protease-like domain interface [polypeptide binding]; other site 697283001807 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 697283001808 catalytic residues [active] 697283001809 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 697283001810 DDE superfamily endonuclease; Region: DDE_3; pfam13358 697283001811 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 697283001812 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 697283001813 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 697283001814 active site 697283001815 phosphorylation site [posttranslational modification] 697283001816 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 697283001817 active site 697283001818 P-loop; other site 697283001819 phosphorylation site [posttranslational modification] 697283001820 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 697283001821 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 697283001822 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 697283001823 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 697283001824 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 697283001825 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 697283001826 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 697283001827 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 697283001828 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 697283001829 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 697283001830 G5 domain; Region: G5; pfam07501 697283001831 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 697283001832 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 697283001833 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 697283001834 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 697283001835 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 697283001836 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 697283001837 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 697283001838 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 697283001839 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 697283001840 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 697283001841 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 697283001842 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 697283001843 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 697283001844 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 697283001845 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 697283001846 catalytic residues [active] 697283001847 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 697283001848 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 697283001849 SelR domain; Region: SelR; pfam01641 697283001850 Response regulator receiver domain; Region: Response_reg; pfam00072 697283001851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697283001852 active site 697283001853 phosphorylation site [posttranslational modification] 697283001854 intermolecular recognition site; other site 697283001855 dimerization interface [polypeptide binding]; other site 697283001856 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 697283001857 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 697283001858 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 697283001859 Cache domain; Region: Cache_1; pfam02743 697283001860 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 697283001861 dimerization interface [polypeptide binding]; other site 697283001862 Histidine kinase; Region: His_kinase; pfam06580 697283001863 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697283001864 ATP binding site [chemical binding]; other site 697283001865 Mg2+ binding site [ion binding]; other site 697283001866 G-X-G motif; other site 697283001867 hypothetical protein; Provisional; Region: PRK13690 697283001868 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 697283001869 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 697283001870 G5 domain; Region: G5; pfam07501 697283001871 G5 domain; Region: G5; pfam07501 697283001872 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 697283001873 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 697283001874 aminodeoxychorismate synthase; Provisional; Region: PRK07508 697283001875 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 697283001876 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 697283001877 substrate-cofactor binding pocket; other site 697283001878 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 697283001879 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697283001880 catalytic residue [active] 697283001881 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 697283001882 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 697283001883 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 697283001884 nucleotide binding site [chemical binding]; other site 697283001885 thymidylate synthase; Reviewed; Region: thyA; PRK01827 697283001886 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 697283001887 dimerization interface [polypeptide binding]; other site 697283001888 active site 697283001889 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 697283001890 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 697283001891 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 697283001892 GTPases [General function prediction only]; Region: HflX; COG2262 697283001893 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 697283001894 HflX GTPase family; Region: HflX; cd01878 697283001895 G1 box; other site 697283001896 GTP/Mg2+ binding site [chemical binding]; other site 697283001897 Switch I region; other site 697283001898 G2 box; other site 697283001899 G3 box; other site 697283001900 Switch II region; other site 697283001901 G4 box; other site 697283001902 G5 box; other site 697283001903 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 697283001904 ribonuclease Z; Region: RNase_Z; TIGR02651 697283001905 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 697283001906 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697283001907 NAD(P) binding site [chemical binding]; other site 697283001908 active site 697283001909 Transcriptional regulator [Transcription]; Region: LysR; COG0583 697283001910 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 697283001911 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 697283001912 dimerization interface [polypeptide binding]; other site 697283001913 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 697283001914 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 697283001915 active site residue [active] 697283001916 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 697283001917 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 697283001918 RNA binding surface [nucleotide binding]; other site 697283001919 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 697283001920 active site 697283001921 uracil binding [chemical binding]; other site 697283001922 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 697283001923 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 697283001924 G1 box; other site 697283001925 putative GEF interaction site [polypeptide binding]; other site 697283001926 GTP/Mg2+ binding site [chemical binding]; other site 697283001927 Switch I region; other site 697283001928 G2 box; other site 697283001929 G3 box; other site 697283001930 Switch II region; other site 697283001931 G4 box; other site 697283001932 G5 box; other site 697283001933 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 697283001934 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 697283001935 Protein of unknown function (DUF3165); Region: DUF3165; pfam11364 697283001936 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 697283001937 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 697283001938 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 697283001939 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697283001940 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 697283001941 Walker A/P-loop; other site 697283001942 ATP binding site [chemical binding]; other site 697283001943 Q-loop/lid; other site 697283001944 ABC transporter signature motif; other site 697283001945 Walker B; other site 697283001946 D-loop; other site 697283001947 H-loop/switch region; other site 697283001948 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 697283001949 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 697283001950 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 697283001951 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 697283001952 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 697283001953 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 697283001954 homodimer interface [polypeptide binding]; other site 697283001955 active site 697283001956 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 697283001957 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 697283001958 Cell division protein FtsQ; Region: FtsQ; pfam03799 697283001959 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 697283001960 active site 697283001961 dimer interface [polypeptide binding]; other site 697283001962 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 697283001963 active site 697283001964 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 697283001965 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697283001966 Walker A/P-loop; other site 697283001967 ATP binding site [chemical binding]; other site 697283001968 Q-loop/lid; other site 697283001969 ABC transporter signature motif; other site 697283001970 Walker B; other site 697283001971 D-loop; other site 697283001972 H-loop/switch region; other site 697283001973 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 697283001974 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 697283001975 substrate binding pocket [chemical binding]; other site 697283001976 membrane-bound complex binding site; other site 697283001977 hinge residues; other site 697283001978 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 697283001979 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 697283001980 Walker A/P-loop; other site 697283001981 ATP binding site [chemical binding]; other site 697283001982 Q-loop/lid; other site 697283001983 ABC transporter signature motif; other site 697283001984 Walker B; other site 697283001985 D-loop; other site 697283001986 H-loop/switch region; other site 697283001987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283001988 dimer interface [polypeptide binding]; other site 697283001989 conserved gate region; other site 697283001990 putative PBP binding loops; other site 697283001991 ABC-ATPase subunit interface; other site 697283001992 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283001993 dimer interface [polypeptide binding]; other site 697283001994 conserved gate region; other site 697283001995 putative PBP binding loops; other site 697283001996 ABC-ATPase subunit interface; other site 697283001997 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 697283001998 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 697283001999 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 697283002000 dimer interface [polypeptide binding]; other site 697283002001 putative anticodon binding site; other site 697283002002 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 697283002003 motif 1; other site 697283002004 active site 697283002005 motif 2; other site 697283002006 motif 3; other site 697283002007 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 697283002008 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 697283002009 teramer interface [polypeptide binding]; other site 697283002010 active site 697283002011 FMN binding site [chemical binding]; other site 697283002012 catalytic residues [active] 697283002013 Putative transcription activator [Transcription]; Region: TenA; COG0819 697283002014 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 697283002015 substrate binding site [chemical binding]; other site 697283002016 multimerization interface [polypeptide binding]; other site 697283002017 ATP binding site [chemical binding]; other site 697283002018 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 697283002019 thiamine phosphate binding site [chemical binding]; other site 697283002020 active site 697283002021 pyrophosphate binding site [ion binding]; other site 697283002022 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 697283002023 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 697283002024 Walker A/P-loop; other site 697283002025 ATP binding site [chemical binding]; other site 697283002026 ABC transporter; Region: ABC_tran; pfam00005 697283002027 Q-loop/lid; other site 697283002028 ABC transporter signature motif; other site 697283002029 Walker B; other site 697283002030 D-loop; other site 697283002031 H-loop/switch region; other site 697283002032 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697283002033 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 697283002034 Walker A/P-loop; other site 697283002035 ATP binding site [chemical binding]; other site 697283002036 Q-loop/lid; other site 697283002037 ABC transporter signature motif; other site 697283002038 Walker B; other site 697283002039 D-loop; other site 697283002040 H-loop/switch region; other site 697283002041 Putative transcription activator [Transcription]; Region: TenA; COG0819 697283002042 Predicted membrane protein [Function unknown]; Region: COG4732 697283002043 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 697283002044 substrate binding site [chemical binding]; other site 697283002045 multimerization interface [polypeptide binding]; other site 697283002046 ATP binding site [chemical binding]; other site 697283002047 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 697283002048 thiamine phosphate binding site [chemical binding]; other site 697283002049 active site 697283002050 pyrophosphate binding site [ion binding]; other site 697283002051 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 697283002052 dimer interface [polypeptide binding]; other site 697283002053 substrate binding site [chemical binding]; other site 697283002054 ATP binding site [chemical binding]; other site 697283002055 Predicted transcriptional regulator [Transcription]; Region: COG3682 697283002056 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 697283002057 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 697283002058 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 697283002059 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 697283002060 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 697283002061 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 697283002062 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 697283002063 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 697283002064 PYR/PP interface [polypeptide binding]; other site 697283002065 dimer interface [polypeptide binding]; other site 697283002066 tetramer interface [polypeptide binding]; other site 697283002067 TPP binding site [chemical binding]; other site 697283002068 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 697283002069 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 697283002070 TPP-binding site [chemical binding]; other site 697283002071 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 697283002072 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 697283002073 active site 697283002074 DDE superfamily endonuclease; Region: DDE_3; pfam13358 697283002075 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 697283002076 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 697283002077 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 697283002078 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 697283002079 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 697283002080 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 697283002081 Na2 binding site [ion binding]; other site 697283002082 putative substrate binding site 1 [chemical binding]; other site 697283002083 Na binding site 1 [ion binding]; other site 697283002084 putative substrate binding site 2 [chemical binding]; other site 697283002085 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 697283002086 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 697283002087 DNA binding residues [nucleotide binding] 697283002088 dimer interface [polypeptide binding]; other site 697283002089 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 697283002090 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 697283002091 putative active site [active] 697283002092 nucleotide binding site [chemical binding]; other site 697283002093 nudix motif; other site 697283002094 putative metal binding site [ion binding]; other site 697283002095 HI0933-like protein; Region: HI0933_like; pfam03486 697283002096 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 697283002097 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 697283002098 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 697283002099 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 697283002100 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 697283002101 catalytic motif [active] 697283002102 Zn binding site [ion binding]; other site 697283002103 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 697283002104 active site 697283002105 Clp protease; Region: CLP_protease; pfam00574 697283002106 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 697283002107 oligomer interface [polypeptide binding]; other site 697283002108 active site residues [active] 697283002109 hypothetical protein; Provisional; Region: PRK02302 697283002110 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 697283002111 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 697283002112 putative ligand binding site [chemical binding]; other site 697283002113 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 697283002114 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 697283002115 TM-ABC transporter signature motif; other site 697283002116 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 697283002117 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 697283002118 TM-ABC transporter signature motif; other site 697283002119 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 697283002120 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 697283002121 Walker A/P-loop; other site 697283002122 ATP binding site [chemical binding]; other site 697283002123 Q-loop/lid; other site 697283002124 ABC transporter signature motif; other site 697283002125 Walker B; other site 697283002126 D-loop; other site 697283002127 H-loop/switch region; other site 697283002128 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 697283002129 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 697283002130 Walker A/P-loop; other site 697283002131 ATP binding site [chemical binding]; other site 697283002132 Q-loop/lid; other site 697283002133 ABC transporter signature motif; other site 697283002134 Walker B; other site 697283002135 D-loop; other site 697283002136 H-loop/switch region; other site 697283002137 FOG: CBS domain [General function prediction only]; Region: COG0517 697283002138 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 697283002139 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 697283002140 PCRF domain; Region: PCRF; pfam03462 697283002141 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 697283002142 RF-1 domain; Region: RF-1; pfam00472 697283002143 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 697283002144 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697283002145 Walker A/P-loop; other site 697283002146 ATP binding site [chemical binding]; other site 697283002147 Q-loop/lid; other site 697283002148 ABC transporter signature motif; other site 697283002149 Walker B; other site 697283002150 D-loop; other site 697283002151 H-loop/switch region; other site 697283002152 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 697283002153 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 697283002154 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 697283002155 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 697283002156 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 697283002157 active site turn [active] 697283002158 phosphorylation site [posttranslational modification] 697283002159 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 697283002160 HPr interaction site; other site 697283002161 glycerol kinase (GK) interaction site [polypeptide binding]; other site 697283002162 active site 697283002163 phosphorylation site [posttranslational modification] 697283002164 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 697283002165 putative catalytic site [active] 697283002166 putative metal binding site [ion binding]; other site 697283002167 putative phosphate binding site [ion binding]; other site 697283002168 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 697283002169 DEAD-like helicases superfamily; Region: DEXDc; smart00487 697283002170 ATP binding site [chemical binding]; other site 697283002171 Mg++ binding site [ion binding]; other site 697283002172 motif III; other site 697283002173 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 697283002174 nucleotide binding region [chemical binding]; other site 697283002175 ATP-binding site [chemical binding]; other site 697283002176 S-adenosylmethionine synthetase; Validated; Region: PRK05250 697283002177 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 697283002178 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 697283002179 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 697283002180 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 697283002181 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 697283002182 active site 697283002183 FMN binding site [chemical binding]; other site 697283002184 substrate binding site [chemical binding]; other site 697283002185 catalytic residues [active] 697283002186 homodimer interface [polypeptide binding]; other site 697283002187 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 697283002188 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 697283002189 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 697283002190 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 697283002191 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 697283002192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 697283002193 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 697283002194 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697283002195 FeS/SAM binding site; other site 697283002196 VanZ like family; Region: VanZ; pfam04892 697283002197 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 697283002198 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 697283002199 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 697283002200 ABC transporter; Region: ABC_tran_2; pfam12848 697283002201 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 697283002202 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 697283002203 active site 697283002204 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 697283002205 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 697283002206 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 697283002207 KH domain; Region: KH_4; pfam13083 697283002208 G-X-X-G motif; other site 697283002209 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 697283002210 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 697283002211 RimM N-terminal domain; Region: RimM; pfam01782 697283002212 PRC-barrel domain; Region: PRC; pfam05239 697283002213 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 697283002214 ATP cone domain; Region: ATP-cone; pfam03477 697283002215 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 697283002216 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 697283002217 glutathione reductase; Validated; Region: PRK06116 697283002218 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 697283002219 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 697283002220 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 697283002221 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 697283002222 HlyD family secretion protein; Region: HlyD_3; pfam13437 697283002223 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 697283002224 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 697283002225 Walker A/P-loop; other site 697283002226 ATP binding site [chemical binding]; other site 697283002227 Q-loop/lid; other site 697283002228 ABC transporter signature motif; other site 697283002229 Walker B; other site 697283002230 D-loop; other site 697283002231 H-loop/switch region; other site 697283002232 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 697283002233 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 697283002234 FtsX-like permease family; Region: FtsX; pfam02687 697283002235 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 697283002236 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 697283002237 active site 697283002238 HIGH motif; other site 697283002239 KMSKS motif; other site 697283002240 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 697283002241 tRNA binding surface [nucleotide binding]; other site 697283002242 anticodon binding site; other site 697283002243 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 697283002244 dimer interface [polypeptide binding]; other site 697283002245 putative tRNA-binding site [nucleotide binding]; other site 697283002246 Predicted transcriptional regulators [Transcription]; Region: COG1695 697283002247 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 697283002248 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 697283002249 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 697283002250 active site 697283002251 catalytic tetrad [active] 697283002252 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 697283002253 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 697283002254 classical (c) SDRs; Region: SDR_c; cd05233 697283002255 NAD(P) binding site [chemical binding]; other site 697283002256 active site 697283002257 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 697283002258 nudix motif; other site 697283002259 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 697283002260 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 697283002261 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 697283002262 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 697283002263 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 697283002264 Zn binding site [ion binding]; other site 697283002265 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 697283002266 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697283002267 active site 697283002268 phosphorylation site [posttranslational modification] 697283002269 intermolecular recognition site; other site 697283002270 dimerization interface [polypeptide binding]; other site 697283002271 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 697283002272 DNA binding site [nucleotide binding] 697283002273 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 697283002274 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 697283002275 dimer interface [polypeptide binding]; other site 697283002276 phosphorylation site [posttranslational modification] 697283002277 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697283002278 ATP binding site [chemical binding]; other site 697283002279 Mg2+ binding site [ion binding]; other site 697283002280 G-X-G motif; other site 697283002281 Protein of unknown function (DUF3270); Region: DUF3270; pfam11674 697283002282 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 697283002283 Peptidase family U32; Region: Peptidase_U32; pfam01136 697283002284 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246 697283002285 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 697283002286 active site 697283002287 catalytic site [active] 697283002288 substrate binding site [chemical binding]; other site 697283002289 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 697283002290 ATP binding site [chemical binding]; other site 697283002291 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 697283002292 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 697283002293 DJ-1 family protein; Region: not_thiJ; TIGR01383 697283002294 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 697283002295 conserved cys residue [active] 697283002296 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 697283002297 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697283002298 motif II; other site 697283002299 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 697283002300 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697283002301 Mg2+ binding site [ion binding]; other site 697283002302 G-X-G motif; other site 697283002303 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 697283002304 anchoring element; other site 697283002305 dimer interface [polypeptide binding]; other site 697283002306 ATP binding site [chemical binding]; other site 697283002307 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 697283002308 active site 697283002309 putative metal-binding site [ion binding]; other site 697283002310 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 697283002311 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 697283002312 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 697283002313 Transposase; Region: DDE_Tnp_ISL3; pfam01610 697283002314 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 697283002315 Transposase; Region: DDE_Tnp_ISL3; pfam01610 697283002316 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 697283002317 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 697283002318 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697283002319 Helix-turn-helix domain; Region: HTH_28; pfam13518 697283002320 HTH-like domain; Region: HTH_21; pfam13276 697283002321 Integrase core domain; Region: rve; pfam00665 697283002322 Integrase core domain; Region: rve_2; pfam13333 697283002323 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 697283002324 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 697283002325 Helix-turn-helix domain; Region: HTH_28; pfam13518 697283002326 Winged helix-turn helix; Region: HTH_29; pfam13551 697283002327 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 697283002328 DDE superfamily endonuclease; Region: DDE_3; pfam13358 697283002329 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 697283002330 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697283002331 Walker A motif; other site 697283002332 ATP binding site [chemical binding]; other site 697283002333 Walker B motif; other site 697283002334 arginine finger; other site 697283002335 UvrB/uvrC motif; Region: UVR; pfam02151 697283002336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697283002337 Walker A motif; other site 697283002338 ATP binding site [chemical binding]; other site 697283002339 Walker B motif; other site 697283002340 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 697283002341 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 697283002342 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 697283002343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283002344 dimer interface [polypeptide binding]; other site 697283002345 conserved gate region; other site 697283002346 putative PBP binding loops; other site 697283002347 ABC-ATPase subunit interface; other site 697283002348 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 697283002349 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 697283002350 Walker A/P-loop; other site 697283002351 ATP binding site [chemical binding]; other site 697283002352 Q-loop/lid; other site 697283002353 ABC transporter signature motif; other site 697283002354 Walker B; other site 697283002355 D-loop; other site 697283002356 H-loop/switch region; other site 697283002357 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 697283002358 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 697283002359 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 697283002360 homodimer interface [polypeptide binding]; other site 697283002361 NADP binding site [chemical binding]; other site 697283002362 substrate binding site [chemical binding]; other site 697283002363 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 697283002364 putative substrate binding site [chemical binding]; other site 697283002365 putative ATP binding site [chemical binding]; other site 697283002366 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 697283002367 tetramer (dimer of dimers) interface [polypeptide binding]; other site 697283002368 active site 697283002369 dimer interface [polypeptide binding]; other site 697283002370 phosphopentomutase; Provisional; Region: PRK05362 697283002371 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 697283002372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 697283002373 purine nucleoside phosphorylase; Provisional; Region: PRK08202 697283002374 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 697283002375 nucleophilic elbow; other site 697283002376 catalytic triad; other site 697283002377 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 697283002378 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 697283002379 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 697283002380 topology modulation protein; Provisional; Region: PRK07261 697283002381 AAA domain; Region: AAA_17; pfam13207 697283002382 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 697283002383 pantothenate kinase; Provisional; Region: PRK05439 697283002384 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 697283002385 ATP-binding site [chemical binding]; other site 697283002386 CoA-binding site [chemical binding]; other site 697283002387 Mg2+-binding site [ion binding]; other site 697283002388 Methyltransferase domain; Region: Methyltransf_31; pfam13847 697283002389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697283002390 S-adenosylmethionine binding site [chemical binding]; other site 697283002391 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 697283002392 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 697283002393 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 697283002394 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 697283002395 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 697283002396 intersubunit interface [polypeptide binding]; other site 697283002397 active site 697283002398 catalytic residue [active] 697283002399 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 697283002400 active site 697283002401 catalytic motif [active] 697283002402 Zn binding site [ion binding]; other site 697283002403 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 697283002404 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 697283002405 ligand binding site [chemical binding]; other site 697283002406 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 697283002407 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 697283002408 Walker A/P-loop; other site 697283002409 ATP binding site [chemical binding]; other site 697283002410 Q-loop/lid; other site 697283002411 ABC transporter signature motif; other site 697283002412 Walker B; other site 697283002413 D-loop; other site 697283002414 H-loop/switch region; other site 697283002415 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 697283002416 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 697283002417 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 697283002418 TM-ABC transporter signature motif; other site 697283002419 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 697283002420 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 697283002421 TM-ABC transporter signature motif; other site 697283002422 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697283002423 Helix-turn-helix domain; Region: HTH_28; pfam13518 697283002424 HTH-like domain; Region: HTH_21; pfam13276 697283002425 Integrase core domain; Region: rve; pfam00665 697283002426 Integrase core domain; Region: rve_2; pfam13333 697283002427 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 697283002428 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 697283002429 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697283002430 Mg2+ binding site [ion binding]; other site 697283002431 G-X-G motif; other site 697283002432 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 697283002433 anchoring element; other site 697283002434 dimer interface [polypeptide binding]; other site 697283002435 ATP binding site [chemical binding]; other site 697283002436 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 697283002437 active site 697283002438 putative metal-binding site [ion binding]; other site 697283002439 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 697283002440 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 697283002441 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 697283002442 CAP-like domain; other site 697283002443 active site 697283002444 primary dimer interface [polypeptide binding]; other site 697283002445 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 697283002446 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 697283002447 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 697283002448 homodimer interface [polypeptide binding]; other site 697283002449 substrate-cofactor binding pocket; other site 697283002450 catalytic residue [active] 697283002451 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 697283002452 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 697283002453 Predicted membrane protein [Function unknown]; Region: COG3819 697283002454 Predicted membrane protein [Function unknown]; Region: COG3817 697283002455 Protein of unknown function (DUF979); Region: DUF979; pfam06166 697283002456 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 697283002457 putative substrate binding pocket [chemical binding]; other site 697283002458 AC domain interface; other site 697283002459 catalytic triad [active] 697283002460 AB domain interface; other site 697283002461 interchain disulfide; other site 697283002462 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 697283002463 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 697283002464 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 697283002465 RNA binding site [nucleotide binding]; other site 697283002466 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 697283002467 RNA binding site [nucleotide binding]; other site 697283002468 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 697283002469 RNA binding site [nucleotide binding]; other site 697283002470 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 697283002471 RNA binding site [nucleotide binding]; other site 697283002472 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 697283002473 GAF domain; Region: GAF_2; pfam13185 697283002474 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 697283002475 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697283002476 Walker A motif; other site 697283002477 ATP binding site [chemical binding]; other site 697283002478 Walker B motif; other site 697283002479 arginine finger; other site 697283002480 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 697283002481 Protein of unknown function (DUF3272); Region: DUF3272; pfam11676 697283002482 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 697283002483 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 697283002484 Walker A/P-loop; other site 697283002485 ATP binding site [chemical binding]; other site 697283002486 Q-loop/lid; other site 697283002487 ABC transporter signature motif; other site 697283002488 Walker B; other site 697283002489 D-loop; other site 697283002490 H-loop/switch region; other site 697283002491 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 697283002492 FeS assembly protein SufD; Region: sufD; TIGR01981 697283002493 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 697283002494 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 697283002495 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 697283002496 catalytic residue [active] 697283002497 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 697283002498 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 697283002499 trimerization site [polypeptide binding]; other site 697283002500 active site 697283002501 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 697283002502 FeS assembly protein SufB; Region: sufB; TIGR01980 697283002503 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 697283002504 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 697283002505 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 697283002506 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 697283002507 Domain of unknown function DUF20; Region: UPF0118; pfam01594 697283002508 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 697283002509 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 697283002510 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 697283002511 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 697283002512 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 697283002513 putative substrate binding site [chemical binding]; other site 697283002514 putative ATP binding site [chemical binding]; other site 697283002515 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 697283002516 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 697283002517 active site 697283002518 phosphorylation site [posttranslational modification] 697283002519 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 697283002520 active site 697283002521 P-loop; other site 697283002522 phosphorylation site [posttranslational modification] 697283002523 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 697283002524 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 697283002525 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 697283002526 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 697283002527 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 697283002528 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 697283002529 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 697283002530 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 697283002531 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 697283002532 catalytic residue [active] 697283002533 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 697283002534 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 697283002535 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 697283002536 Ligand Binding Site [chemical binding]; other site 697283002537 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 697283002538 Putative esterase; Region: Esterase; pfam00756 697283002539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 697283002540 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 697283002541 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 697283002542 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 697283002543 HsdM N-terminal domain; Region: HsdM_N; pfam12161 697283002544 Methyltransferase domain; Region: Methyltransf_26; pfam13659 697283002545 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 697283002546 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 697283002547 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 697283002548 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 697283002549 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 697283002550 active site 697283002551 catalytic residues [active] 697283002552 DNA binding site [nucleotide binding] 697283002553 Int/Topo IB signature motif; other site 697283002554 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 697283002555 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 697283002556 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 697283002557 Arginine repressor [Transcription]; Region: ArgR; COG1438 697283002558 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 697283002559 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 697283002560 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 697283002561 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168 697283002562 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 697283002563 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 697283002564 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 697283002565 active site 697283002566 PHP Thumb interface [polypeptide binding]; other site 697283002567 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 697283002568 generic binding surface II; other site 697283002569 generic binding surface I; other site 697283002570 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 697283002571 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 697283002572 active site 697283002573 ADP/pyrophosphate binding site [chemical binding]; other site 697283002574 dimerization interface [polypeptide binding]; other site 697283002575 allosteric effector site; other site 697283002576 fructose-1,6-bisphosphate binding site; other site 697283002577 pyruvate kinase; Provisional; Region: PRK05826 697283002578 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 697283002579 domain interfaces; other site 697283002580 active site 697283002581 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 697283002582 DNA binding site [nucleotide binding] 697283002583 active site 697283002584 Int/Topo IB signature motif; other site 697283002585 Domain of unknown function (DUF4300); Region: DUF4300; pfam14133 697283002586 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 697283002587 Predicted membrane protein [Function unknown]; Region: COG3689 697283002588 Predicted permeases [General function prediction only]; Region: COG0701 697283002589 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 697283002590 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 697283002591 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 697283002592 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 697283002593 RNA binding site [nucleotide binding]; other site 697283002594 SprT homologues; Region: SprT; cl01182 697283002595 hypothetical protein; Provisional; Region: PRK04351 697283002596 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 697283002597 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 697283002598 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 697283002599 Walker A/P-loop; other site 697283002600 ATP binding site [chemical binding]; other site 697283002601 Q-loop/lid; other site 697283002602 ABC transporter signature motif; other site 697283002603 Walker B; other site 697283002604 D-loop; other site 697283002605 H-loop/switch region; other site 697283002606 FtsX-like permease family; Region: FtsX; pfam02687 697283002607 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 697283002608 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 697283002609 Integrase core domain; Region: rve; pfam00665 697283002610 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 697283002611 Helix-turn-helix domain; Region: HTH_38; pfam13936 697283002612 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 697283002613 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 697283002614 homodimer interface [polypeptide binding]; other site 697283002615 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697283002616 catalytic residue [active] 697283002617 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 697283002618 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 697283002619 Transposase; Region: DEDD_Tnp_IS110; pfam01548 697283002620 spermidine synthase; Provisional; Region: PRK00811 697283002621 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697283002622 S-adenosylmethionine binding site [chemical binding]; other site 697283002623 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 697283002624 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 697283002625 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 697283002626 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 697283002627 dimer interface [polypeptide binding]; other site 697283002628 active site 697283002629 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 697283002630 catalytic residues [active] 697283002631 substrate binding site [chemical binding]; other site 697283002632 agmatine deiminase; Provisional; Region: PRK13551 697283002633 agmatine deiminase; Region: agmatine_aguA; TIGR03380 697283002634 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 697283002635 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 697283002636 putative active site; other site 697283002637 catalytic triad [active] 697283002638 putative dimer interface [polypeptide binding]; other site 697283002639 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697283002640 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 697283002641 active site 697283002642 motif I; other site 697283002643 motif II; other site 697283002644 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697283002645 CAAX protease self-immunity; Region: Abi; pfam02517 697283002646 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 697283002647 Transcriptional regulator [Transcription]; Region: LysR; COG0583 697283002648 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 697283002649 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 697283002650 dimerization interface [polypeptide binding]; other site 697283002651 lipoprotein signal peptidase; Provisional; Region: PRK14797 697283002652 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 697283002653 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 697283002654 RNA binding surface [nucleotide binding]; other site 697283002655 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 697283002656 active site 697283002657 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 697283002658 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 697283002659 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 697283002660 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 697283002661 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 697283002662 nucleotide binding site [chemical binding]; other site 697283002663 homotetrameric interface [polypeptide binding]; other site 697283002664 putative phosphate binding site [ion binding]; other site 697283002665 putative allosteric binding site; other site 697283002666 PUA domain; Region: PUA; pfam01472 697283002667 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 697283002668 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 697283002669 putative catalytic cysteine [active] 697283002670 pyrroline-5-carboxylate reductase; Region: PLN02688 697283002671 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 697283002672 thymidylate kinase; Validated; Region: tmk; PRK00698 697283002673 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 697283002674 TMP-binding site; other site 697283002675 ATP-binding site [chemical binding]; other site 697283002676 DNA polymerase III subunit delta'; Validated; Region: PRK07276 697283002677 DNA polymerase III subunit delta'; Validated; Region: PRK08485 697283002678 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 697283002679 Predicted methyltransferases [General function prediction only]; Region: COG0313 697283002680 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 697283002681 putative SAM binding site [chemical binding]; other site 697283002682 putative homodimer interface [polypeptide binding]; other site 697283002683 Uncharacterized conserved protein [Function unknown]; Region: COG4283 697283002684 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 697283002685 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 697283002686 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 697283002687 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 697283002688 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 697283002689 Glucose inhibited division protein A; Region: GIDA; pfam01134 697283002690 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 697283002691 putative nucleotide binding site [chemical binding]; other site 697283002692 uridine monophosphate binding site [chemical binding]; other site 697283002693 homohexameric interface [polypeptide binding]; other site 697283002694 ribosome recycling factor; Reviewed; Region: frr; PRK00083 697283002695 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 697283002696 hinge region; other site 697283002697 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 697283002698 S1 domain; Region: S1_2; pfam13509 697283002699 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 697283002700 hypothetical protein; Provisional; Region: PRK13672 697283002701 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 697283002702 PhoH-like protein; Region: PhoH; pfam02562 697283002703 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 697283002704 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697283002705 Coenzyme A binding pocket [chemical binding]; other site 697283002706 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 697283002707 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 697283002708 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 697283002709 SLBB domain; Region: SLBB; pfam10531 697283002710 comEA protein; Region: comE; TIGR01259 697283002711 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 697283002712 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 697283002713 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 697283002714 Competence protein; Region: Competence; pfam03772 697283002715 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 697283002716 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 697283002717 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 697283002718 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 697283002719 Walker A/P-loop; other site 697283002720 ATP binding site [chemical binding]; other site 697283002721 Q-loop/lid; other site 697283002722 ABC transporter signature motif; other site 697283002723 Walker B; other site 697283002724 D-loop; other site 697283002725 H-loop/switch region; other site 697283002726 ribosomal protein L20 leader 697283002727 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 697283002728 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 697283002729 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 697283002730 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 697283002731 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 697283002732 23S rRNA binding site [nucleotide binding]; other site 697283002733 L21 binding site [polypeptide binding]; other site 697283002734 L13 binding site [polypeptide binding]; other site 697283002735 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 697283002736 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 697283002737 dimer interface [polypeptide binding]; other site 697283002738 active site 697283002739 metal binding site [ion binding]; metal-binding site 697283002740 glutathione binding site [chemical binding]; other site 697283002741 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 697283002742 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 697283002743 FAD binding pocket [chemical binding]; other site 697283002744 FAD binding motif [chemical binding]; other site 697283002745 phosphate binding motif [ion binding]; other site 697283002746 beta-alpha-beta structure motif; other site 697283002747 NAD binding pocket [chemical binding]; other site 697283002748 Iron coordination center [ion binding]; other site 697283002749 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 697283002750 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 697283002751 heterodimer interface [polypeptide binding]; other site 697283002752 active site 697283002753 FMN binding site [chemical binding]; other site 697283002754 homodimer interface [polypeptide binding]; other site 697283002755 substrate binding site [chemical binding]; other site 697283002756 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 697283002757 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 697283002758 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 697283002759 Domain of unknown function (DUF814); Region: DUF814; pfam05670 697283002760 metal-binding heat shock protein; Provisional; Region: PRK00016 697283002761 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 697283002762 GTPase Era; Reviewed; Region: era; PRK00089 697283002763 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 697283002764 G1 box; other site 697283002765 GTP/Mg2+ binding site [chemical binding]; other site 697283002766 Switch I region; other site 697283002767 G2 box; other site 697283002768 Switch II region; other site 697283002769 G3 box; other site 697283002770 G4 box; other site 697283002771 G5 box; other site 697283002772 KH domain; Region: KH_2; pfam07650 697283002773 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 697283002774 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 697283002775 DNA binding site [nucleotide binding] 697283002776 catalytic residue [active] 697283002777 H2TH interface [polypeptide binding]; other site 697283002778 putative catalytic residues [active] 697283002779 turnover-facilitating residue; other site 697283002780 intercalation triad [nucleotide binding]; other site 697283002781 8OG recognition residue [nucleotide binding]; other site 697283002782 putative reading head residues; other site 697283002783 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 697283002784 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 697283002785 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 697283002786 dephospho-CoA kinase; Region: TIGR00152 697283002787 CoA-binding site [chemical binding]; other site 697283002788 ATP-binding [chemical binding]; other site 697283002789 drug efflux system protein MdtG; Provisional; Region: PRK09874 697283002790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697283002791 putative substrate translocation pore; other site 697283002792 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 697283002793 ribonuclease R; Region: RNase_R; TIGR02063 697283002794 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 697283002795 RNB domain; Region: RNB; pfam00773 697283002796 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 697283002797 RNA binding site [nucleotide binding]; other site 697283002798 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 697283002799 SmpB-tmRNA interface; other site 697283002800 tellurite resistance protein TehB; Provisional; Region: PRK12335 697283002801 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 697283002802 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697283002803 S-adenosylmethionine binding site [chemical binding]; other site 697283002804 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 697283002805 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 697283002806 active site 697283002807 Zn binding site [ion binding]; other site 697283002808 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 697283002809 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697283002810 S-adenosylmethionine binding site [chemical binding]; other site 697283002811 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 697283002812 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 697283002813 Integrase core domain; Region: rve; pfam00665 697283002814 Integrase core domain; Region: rve_2; pfam13333 697283002815 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 697283002816 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 697283002817 catalytic core [active] 697283002818 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 697283002819 putative deacylase active site [active] 697283002820 Predicted membrane protein [Function unknown]; Region: COG2035 697283002821 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 697283002822 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 697283002823 active site 697283002824 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 697283002825 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 697283002826 Substrate binding site; other site 697283002827 Mg++ binding site; other site 697283002828 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 697283002829 active site 697283002830 substrate binding site [chemical binding]; other site 697283002831 CoA binding site [chemical binding]; other site 697283002832 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 697283002833 dimer interface [polypeptide binding]; other site 697283002834 ADP-ribose binding site [chemical binding]; other site 697283002835 active site 697283002836 nudix motif; other site 697283002837 metal binding site [ion binding]; metal-binding site 697283002838 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 697283002839 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 697283002840 MarR family; Region: MarR_2; cl17246 697283002841 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 697283002842 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 697283002843 active site 697283002844 catalytic site [active] 697283002845 substrate binding site [chemical binding]; other site 697283002846 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 697283002847 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 697283002848 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 697283002849 putative active site [active] 697283002850 catalytic site [active] 697283002851 putative metal binding site [ion binding]; other site 697283002852 Transposase; Region: HTH_Tnp_IS630; pfam01710 697283002853 Helix-turn-helix domain; Region: HTH_28; pfam13518 697283002854 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 697283002855 DDE superfamily endonuclease; Region: DDE_3; pfam13358 697283002856 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 697283002857 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 697283002858 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 697283002859 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 697283002860 catalytic residues [active] 697283002861 amino acid transporter; Region: 2A0306; TIGR00909 697283002862 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 697283002863 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 697283002864 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 697283002865 metal binding site [ion binding]; metal-binding site 697283002866 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 697283002867 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 697283002868 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 697283002869 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 697283002870 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 697283002871 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697283002872 motif II; other site 697283002873 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 697283002874 ligand binding site [chemical binding]; other site 697283002875 active site 697283002876 UGI interface [polypeptide binding]; other site 697283002877 catalytic site [active] 697283002878 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 697283002879 putative active site [active] 697283002880 nucleotide binding site [chemical binding]; other site 697283002881 nudix motif; other site 697283002882 putative metal binding site [ion binding]; other site 697283002883 dihydroorotase; Validated; Region: pyrC; PRK09357 697283002884 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 697283002885 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 697283002886 active site 697283002887 multidrug efflux protein; Reviewed; Region: PRK01766 697283002888 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 697283002889 cation binding site [ion binding]; other site 697283002890 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 697283002891 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 697283002892 tetramer interface [polypeptide binding]; other site 697283002893 TPP-binding site [chemical binding]; other site 697283002894 heterodimer interface [polypeptide binding]; other site 697283002895 phosphorylation loop region [posttranslational modification] 697283002896 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 697283002897 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 697283002898 alpha subunit interface [polypeptide binding]; other site 697283002899 TPP binding site [chemical binding]; other site 697283002900 heterodimer interface [polypeptide binding]; other site 697283002901 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 697283002902 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 697283002903 e3 binding domain; Region: E3_binding; pfam02817 697283002904 e3 binding domain; Region: E3_binding; pfam02817 697283002905 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 697283002906 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 697283002907 E3 interaction surface; other site 697283002908 lipoyl attachment site [posttranslational modification]; other site 697283002909 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 697283002910 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 697283002911 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 697283002912 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 697283002913 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 697283002914 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 697283002915 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 697283002916 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 697283002917 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 697283002918 active site 697283002919 DNA binding site [nucleotide binding] 697283002920 Int/Topo IB signature motif; other site 697283002921 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 697283002922 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 697283002923 Cl- selectivity filter; other site 697283002924 Cl- binding residues [ion binding]; other site 697283002925 pore gating glutamate residue; other site 697283002926 dimer interface [polypeptide binding]; other site 697283002927 H+/Cl- coupling transport residue; other site 697283002928 TrkA-C domain; Region: TrkA_C; pfam02080 697283002929 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 697283002930 RNA/DNA hybrid binding site [nucleotide binding]; other site 697283002931 active site 697283002932 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 697283002933 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 697283002934 GTP/Mg2+ binding site [chemical binding]; other site 697283002935 G4 box; other site 697283002936 G5 box; other site 697283002937 G1 box; other site 697283002938 Switch I region; other site 697283002939 G2 box; other site 697283002940 G3 box; other site 697283002941 Switch II region; other site 697283002942 G5 domain; Region: G5; pfam07501 697283002943 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 697283002944 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 697283002945 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 697283002946 G5 domain; Region: G5; pfam07501 697283002947 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 697283002948 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 697283002949 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 697283002950 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 697283002951 Part of AAA domain; Region: AAA_19; pfam13245 697283002952 Family description; Region: UvrD_C_2; pfam13538 697283002953 Family description; Region: UvrD_C_2; pfam13538 697283002954 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 697283002955 ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774 697283002956 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 697283002957 Helix-turn-helix domain; Region: HTH_28; pfam13518 697283002958 Winged helix-turn helix; Region: HTH_29; pfam13551 697283002959 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 697283002960 DNA binding site [nucleotide binding] 697283002961 active site 697283002962 Int/Topo IB signature motif; other site 697283002963 enolase; Provisional; Region: eno; PRK00077 697283002964 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 697283002965 dimer interface [polypeptide binding]; other site 697283002966 metal binding site [ion binding]; metal-binding site 697283002967 substrate binding pocket [chemical binding]; other site 697283002968 Uncharacterized conserved protein [Function unknown]; Region: COG5506 697283002969 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 697283002970 glycogen synthase; Provisional; Region: glgA; PRK00654 697283002971 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 697283002972 ADP-binding pocket [chemical binding]; other site 697283002973 homodimer interface [polypeptide binding]; other site 697283002974 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 697283002975 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 697283002976 active site 697283002977 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 697283002978 dimer interface [polypeptide binding]; other site 697283002979 N-terminal domain interface [polypeptide binding]; other site 697283002980 sulfate 1 binding site; other site 697283002981 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 697283002982 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 697283002983 ligand binding site; other site 697283002984 oligomer interface; other site 697283002985 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 697283002986 dimer interface [polypeptide binding]; other site 697283002987 N-terminal domain interface [polypeptide binding]; other site 697283002988 sulfate 1 binding site; other site 697283002989 glycogen branching enzyme; Provisional; Region: PRK12313 697283002990 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 697283002991 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 697283002992 active site 697283002993 catalytic site [active] 697283002994 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 697283002995 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 697283002996 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 697283002997 tetrameric interface [polypeptide binding]; other site 697283002998 activator binding site; other site 697283002999 NADP binding site [chemical binding]; other site 697283003000 substrate binding site [chemical binding]; other site 697283003001 catalytic residues [active] 697283003002 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cl04227 697283003003 pullulanase, type I; Region: pulA_typeI; TIGR02104 697283003004 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 697283003005 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 697283003006 Ca binding site [ion binding]; other site 697283003007 active site 697283003008 catalytic site [active] 697283003009 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 697283003010 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 697283003011 nucleotide binding pocket [chemical binding]; other site 697283003012 K-X-D-G motif; other site 697283003013 catalytic site [active] 697283003014 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 697283003015 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 697283003016 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 697283003017 Dimer interface [polypeptide binding]; other site 697283003018 BRCT sequence motif; other site 697283003019 H+ Antiporter protein; Region: 2A0121; TIGR00900 697283003020 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697283003021 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697283003022 non-specific DNA binding site [nucleotide binding]; other site 697283003023 salt bridge; other site 697283003024 sequence-specific DNA binding site [nucleotide binding]; other site 697283003025 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 697283003026 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 697283003027 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 697283003028 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 697283003029 ABC transporter; Region: ABC_tran_2; pfam12848 697283003030 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 697283003031 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 697283003032 IHF dimer interface [polypeptide binding]; other site 697283003033 IHF - DNA interface [nucleotide binding]; other site 697283003034 EDD domain protein, DegV family; Region: DegV; TIGR00762 697283003035 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 697283003036 Uncharacterized conserved protein [Function unknown]; Region: COG1284 697283003037 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 697283003038 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 697283003039 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 697283003040 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 697283003041 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 697283003042 active site 697283003043 Riboflavin kinase; Region: Flavokinase; smart00904 697283003044 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 697283003045 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 697283003046 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 697283003047 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 697283003048 Predicted membrane protein [Function unknown]; Region: COG3619 697283003049 hypothetical protein; Validated; Region: PRK00153 697283003050 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 697283003051 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 697283003052 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 697283003053 Transposase; Region: DDE_Tnp_ISL3; pfam01610 697283003054 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 697283003055 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 697283003056 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 697283003057 RNA binding surface [nucleotide binding]; other site 697283003058 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 697283003059 active site 697283003060 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 697283003061 ATP-NAD kinase; Region: NAD_kinase; pfam01513 697283003062 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 697283003063 synthetase active site [active] 697283003064 NTP binding site [chemical binding]; other site 697283003065 metal binding site [ion binding]; metal-binding site 697283003066 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 697283003067 putative active site [active] 697283003068 putative metal binding residues [ion binding]; other site 697283003069 signature motif; other site 697283003070 putative triphosphate binding site [ion binding]; other site 697283003071 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 697283003072 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 697283003073 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 697283003074 active site 697283003075 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 697283003076 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 697283003077 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 697283003078 catalytic residue [active] 697283003079 Putative amino acid metabolism; Region: DUF1831; pfam08866 697283003080 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 697283003081 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 697283003082 CoA binding domain; Region: CoA_binding; pfam02629 697283003083 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 697283003084 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 697283003085 catalytic triad [active] 697283003086 hypothetical protein; Reviewed; Region: PRK00024 697283003087 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 697283003088 MPN+ (JAMM) motif; other site 697283003089 Zinc-binding site [ion binding]; other site 697283003090 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 697283003091 Part of AAA domain; Region: AAA_19; pfam13245 697283003092 Family description; Region: UvrD_C_2; pfam13538 697283003093 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 697283003094 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 697283003095 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 697283003096 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 697283003097 active site 697283003098 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 697283003099 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 697283003100 DNA-binding site [nucleotide binding]; DNA binding site 697283003101 DRTGG domain; Region: DRTGG; pfam07085 697283003102 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 697283003103 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 697283003104 active site 2 [active] 697283003105 active site 1 [active] 697283003106 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 697283003107 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 697283003108 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 697283003109 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 697283003110 hinge; other site 697283003111 active site 697283003112 GTPase CgtA; Reviewed; Region: obgE; PRK12297 697283003113 GTP1/OBG; Region: GTP1_OBG; pfam01018 697283003114 Obg GTPase; Region: Obg; cd01898 697283003115 G1 box; other site 697283003116 GTP/Mg2+ binding site [chemical binding]; other site 697283003117 Switch I region; other site 697283003118 G2 box; other site 697283003119 G3 box; other site 697283003120 Switch II region; other site 697283003121 G4 box; other site 697283003122 G5 box; other site 697283003123 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 697283003124 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 697283003125 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 697283003126 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 697283003127 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 697283003128 putative ADP-binding pocket [chemical binding]; other site 697283003129 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 697283003130 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 697283003131 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 697283003132 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 697283003133 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 697283003134 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 697283003135 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697283003136 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 697283003137 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 697283003138 DNA binding residues [nucleotide binding] 697283003139 DNA primase; Validated; Region: dnaG; PRK05667 697283003140 CHC2 zinc finger; Region: zf-CHC2; pfam01807 697283003141 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 697283003142 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 697283003143 active site 697283003144 metal binding site [ion binding]; metal-binding site 697283003145 interdomain interaction site; other site 697283003146 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 697283003147 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697283003148 Walker A/P-loop; other site 697283003149 ATP binding site [chemical binding]; other site 697283003150 Q-loop/lid; other site 697283003151 ABC transporter signature motif; other site 697283003152 Walker B; other site 697283003153 D-loop; other site 697283003154 H-loop/switch region; other site 697283003155 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 697283003156 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 697283003157 TM-ABC transporter signature motif; other site 697283003158 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 697283003159 zinc binding site [ion binding]; other site 697283003160 putative ligand binding site [chemical binding]; other site 697283003161 T-box leader 697283003162 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 697283003163 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 697283003164 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 697283003165 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 697283003166 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 697283003167 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697283003168 sequence-specific DNA binding site [nucleotide binding]; other site 697283003169 salt bridge; other site 697283003170 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 697283003171 UDP-glucose 4-epimerase; Region: PLN02240 697283003172 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 697283003173 NAD binding site [chemical binding]; other site 697283003174 homodimer interface [polypeptide binding]; other site 697283003175 active site 697283003176 substrate binding site [chemical binding]; other site 697283003177 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 697283003178 Lantibiotic streptin immunity protein; Region: Streptin-Immun; pfam11083 697283003179 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 697283003180 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 697283003181 AAA domain; Region: AAA_21; pfam13304 697283003182 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697283003183 ABC transporter signature motif; other site 697283003184 Walker B; other site 697283003185 D-loop; other site 697283003186 H-loop/switch region; other site 697283003187 Zeta toxin; Region: Zeta_toxin; pfam06414 697283003188 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 697283003189 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 697283003190 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697283003191 non-specific DNA binding site [nucleotide binding]; other site 697283003192 salt bridge; other site 697283003193 sequence-specific DNA binding site [nucleotide binding]; other site 697283003194 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 697283003195 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 697283003196 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 697283003197 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 697283003198 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889 697283003199 Protein of unknown function (DUF3801); Region: DUF3801; pfam12687 697283003200 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 697283003201 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 697283003202 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 697283003203 Walker A/P-loop; other site 697283003204 ATP binding site [chemical binding]; other site 697283003205 Q-loop/lid; other site 697283003206 ABC transporter signature motif; other site 697283003207 Walker B; other site 697283003208 D-loop; other site 697283003209 H-loop/switch region; other site 697283003210 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 697283003211 ABC-ATPase subunit interface; other site 697283003212 dimer interface [polypeptide binding]; other site 697283003213 putative PBP binding regions; other site 697283003214 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 697283003215 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 697283003216 ABC-ATPase subunit interface; other site 697283003217 dimer interface [polypeptide binding]; other site 697283003218 putative PBP binding regions; other site 697283003219 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 697283003220 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 697283003221 siderophore binding site; other site 697283003222 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 697283003223 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 697283003224 TRAM domain; Region: TRAM; cl01282 697283003225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697283003226 S-adenosylmethionine binding site [chemical binding]; other site 697283003227 Predicted secreted protein [Function unknown]; Region: COG4086 697283003228 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 697283003229 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 697283003230 Lysozyme-like; Region: Lysozyme_like; pfam13702 697283003231 catalytic residue [active] 697283003232 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 697283003233 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 697283003234 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 697283003235 dimer interface [polypeptide binding]; other site 697283003236 active site 697283003237 glycine-pyridoxal phosphate binding site [chemical binding]; other site 697283003238 folate binding site [chemical binding]; other site 697283003239 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 697283003240 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697283003241 Coenzyme A binding pocket [chemical binding]; other site 697283003242 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 697283003243 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 697283003244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697283003245 S-adenosylmethionine binding site [chemical binding]; other site 697283003246 peptide chain release factor 1; Validated; Region: prfA; PRK00591 697283003247 This domain is found in peptide chain release factors; Region: PCRF; smart00937 697283003248 RF-1 domain; Region: RF-1; pfam00472 697283003249 thymidine kinase; Provisional; Region: PRK04296 697283003250 4-oxalocrotonate tautomerase; Provisional; Region: PRK02289 697283003251 active site 1 [active] 697283003252 dimer interface [polypeptide binding]; other site 697283003253 hexamer interface [polypeptide binding]; other site 697283003254 active site 2 [active] 697283003255 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 697283003256 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 697283003257 trmE is a tRNA modification GTPase; Region: trmE; cd04164 697283003258 G1 box; other site 697283003259 GTP/Mg2+ binding site [chemical binding]; other site 697283003260 Switch I region; other site 697283003261 G2 box; other site 697283003262 Switch II region; other site 697283003263 G3 box; other site 697283003264 G4 box; other site 697283003265 G5 box; other site 697283003266 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 697283003267 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 697283003268 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 697283003269 dimer interface [polypeptide binding]; other site 697283003270 active site 697283003271 catalytic residue [active] 697283003272 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 697283003273 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 697283003274 Predicted membrane protein [Function unknown]; Region: COG4708 697283003275 Predicted membrane protein [Function unknown]; Region: COG2246 697283003276 GtrA-like protein; Region: GtrA; pfam04138 697283003277 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 697283003278 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 697283003279 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 697283003280 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 697283003281 C-terminal domain interface [polypeptide binding]; other site 697283003282 active site 697283003283 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 697283003284 active site 697283003285 N-terminal domain interface [polypeptide binding]; other site 697283003286 peptidase T; Region: peptidase-T; TIGR01882 697283003287 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 697283003288 metal binding site [ion binding]; metal-binding site 697283003289 dimer interface [polypeptide binding]; other site 697283003290 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 697283003291 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 697283003292 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 697283003293 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 697283003294 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 697283003295 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 697283003296 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 697283003297 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 697283003298 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 697283003299 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 697283003300 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 697283003301 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 697283003302 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 697283003303 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 697283003304 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 697283003305 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 697283003306 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 697283003307 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 697283003308 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 697283003309 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 697283003310 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 697283003311 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 697283003312 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 697283003313 dimerization domain swap beta strand [polypeptide binding]; other site 697283003314 regulatory protein interface [polypeptide binding]; other site 697283003315 active site 697283003316 regulatory phosphorylation site [posttranslational modification]; other site 697283003317 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 697283003318 catalytic residues [active] 697283003319 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 697283003320 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 697283003321 Class I ribonucleotide reductase; Region: RNR_I; cd01679 697283003322 active site 697283003323 dimer interface [polypeptide binding]; other site 697283003324 catalytic residues [active] 697283003325 effector binding site; other site 697283003326 R2 peptide binding site; other site 697283003327 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 697283003328 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 697283003329 dimer interface [polypeptide binding]; other site 697283003330 putative radical transfer pathway; other site 697283003331 diiron center [ion binding]; other site 697283003332 tyrosyl radical; other site 697283003333 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 697283003334 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 697283003335 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 697283003336 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 697283003337 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 697283003338 beta-galactosidase; Region: BGL; TIGR03356 697283003339 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 697283003340 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 697283003341 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 697283003342 active site 697283003343 P-loop; other site 697283003344 phosphorylation site [posttranslational modification] 697283003345 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 697283003346 methionine cluster; other site 697283003347 active site 697283003348 phosphorylation site [posttranslational modification] 697283003349 metal binding site [ion binding]; metal-binding site 697283003350 transcriptional antiterminator BglG; Provisional; Region: PRK09772 697283003351 CAT RNA binding domain; Region: CAT_RBD; smart01061 697283003352 PRD domain; Region: PRD; pfam00874 697283003353 PRD domain; Region: PRD; pfam00874 697283003354 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 697283003355 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 697283003356 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 697283003357 putative substrate binding site [chemical binding]; other site 697283003358 putative ATP binding site [chemical binding]; other site 697283003359 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 697283003360 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 697283003361 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 697283003362 catalytic residues [active] 697283003363 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 697283003364 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 697283003365 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 697283003366 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 697283003367 active site 697283003368 P-loop; other site 697283003369 phosphorylation site [posttranslational modification] 697283003370 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 697283003371 active site 697283003372 phosphorylation site [posttranslational modification] 697283003373 GTP-binding protein LepA; Provisional; Region: PRK05433 697283003374 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 697283003375 G1 box; other site 697283003376 putative GEF interaction site [polypeptide binding]; other site 697283003377 GTP/Mg2+ binding site [chemical binding]; other site 697283003378 Switch I region; other site 697283003379 G2 box; other site 697283003380 G3 box; other site 697283003381 Switch II region; other site 697283003382 G4 box; other site 697283003383 G5 box; other site 697283003384 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 697283003385 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 697283003386 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 697283003387 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 697283003388 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 697283003389 active site 697283003390 metal binding site [ion binding]; metal-binding site 697283003391 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 697283003392 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 697283003393 Walker A/P-loop; other site 697283003394 ATP binding site [chemical binding]; other site 697283003395 Q-loop/lid; other site 697283003396 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 697283003397 ABC transporter signature motif; other site 697283003398 Walker B; other site 697283003399 D-loop; other site 697283003400 H-loop/switch region; other site 697283003401 Arginine repressor [Transcription]; Region: ArgR; COG1438 697283003402 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 697283003403 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 697283003404 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 697283003405 S4 RNA-binding domain; Region: S4; smart00363 697283003406 RNA binding surface [nucleotide binding]; other site 697283003407 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 697283003408 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 697283003409 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 697283003410 substrate binding pocket [chemical binding]; other site 697283003411 chain length determination region; other site 697283003412 substrate-Mg2+ binding site; other site 697283003413 catalytic residues [active] 697283003414 aspartate-rich region 1; other site 697283003415 active site lid residues [active] 697283003416 aspartate-rich region 2; other site 697283003417 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 697283003418 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 697283003419 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 697283003420 generic binding surface II; other site 697283003421 generic binding surface I; other site 697283003422 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 697283003423 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 697283003424 Sugar specificity; other site 697283003425 Pyrimidine base specificity; other site 697283003426 ATP-binding site [chemical binding]; other site 697283003427 Enterocin A Immunity; Region: EntA_Immun; pfam08951 697283003428 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 697283003429 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 697283003430 RNA binding site [nucleotide binding]; other site 697283003431 active site 697283003432 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 697283003433 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 697283003434 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 697283003435 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 697283003436 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 697283003437 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 697283003438 catalytic residue [active] 697283003439 Dppa2/4 conserved region; Region: DCR; pfam14047 697283003440 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 697283003441 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 697283003442 active site 697283003443 catalytic site [active] 697283003444 DNA gyrase subunit A; Validated; Region: PRK05560 697283003445 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 697283003446 CAP-like domain; other site 697283003447 active site 697283003448 primary dimer interface [polypeptide binding]; other site 697283003449 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 697283003450 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 697283003451 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 697283003452 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 697283003453 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 697283003454 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 697283003455 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 697283003456 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 697283003457 tetramer (dimer of dimers) interface [polypeptide binding]; other site 697283003458 NAD binding site [chemical binding]; other site 697283003459 dimer interface [polypeptide binding]; other site 697283003460 substrate binding site [chemical binding]; other site 697283003461 Ion channel; Region: Ion_trans_2; pfam07885 697283003462 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 697283003463 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 697283003464 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 697283003465 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 697283003466 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 697283003467 putative active site [active] 697283003468 heme pocket [chemical binding]; other site 697283003469 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 697283003470 dimer interface [polypeptide binding]; other site 697283003471 phosphorylation site [posttranslational modification] 697283003472 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697283003473 ATP binding site [chemical binding]; other site 697283003474 Mg2+ binding site [ion binding]; other site 697283003475 G-X-G motif; other site 697283003476 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 697283003477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697283003478 active site 697283003479 phosphorylation site [posttranslational modification] 697283003480 intermolecular recognition site; other site 697283003481 dimerization interface [polypeptide binding]; other site 697283003482 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 697283003483 DNA binding site [nucleotide binding] 697283003484 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 697283003485 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 697283003486 minor groove reading motif; other site 697283003487 helix-hairpin-helix signature motif; other site 697283003488 substrate binding pocket [chemical binding]; other site 697283003489 active site 697283003490 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 697283003491 DNA binding and oxoG recognition site [nucleotide binding] 697283003492 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 697283003493 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 697283003494 Potassium binding sites [ion binding]; other site 697283003495 Cesium cation binding sites [ion binding]; other site 697283003496 phosphopantothenate--cysteine ligase; Validated; Region: PRK06732 697283003497 phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113 697283003498 Flavoprotein; Region: Flavoprotein; pfam02441 697283003499 Predicted membrane protein [Function unknown]; Region: COG4684 697283003500 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 697283003501 HTH domain; Region: HTH_11; pfam08279 697283003502 3H domain; Region: 3H; pfam02829 697283003503 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 697283003504 putative active site [active] 697283003505 nucleotide binding site [chemical binding]; other site 697283003506 nudix motif; other site 697283003507 putative metal binding site [ion binding]; other site 697283003508 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 697283003509 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697283003510 Coenzyme A binding pocket [chemical binding]; other site 697283003511 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 697283003512 excinuclease ABC subunit B; Provisional; Region: PRK05298 697283003513 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 697283003514 ATP binding site [chemical binding]; other site 697283003515 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 697283003516 nucleotide binding region [chemical binding]; other site 697283003517 ATP-binding site [chemical binding]; other site 697283003518 Ultra-violet resistance protein B; Region: UvrB; pfam12344 697283003519 UvrB/uvrC motif; Region: UVR; pfam02151 697283003520 CAAX protease self-immunity; Region: Abi; pfam02517 697283003521 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 697283003522 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 697283003523 substrate binding pocket [chemical binding]; other site 697283003524 membrane-bound complex binding site; other site 697283003525 hinge residues; other site 697283003526 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 697283003527 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 697283003528 substrate binding pocket [chemical binding]; other site 697283003529 membrane-bound complex binding site; other site 697283003530 hinge residues; other site 697283003531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283003532 dimer interface [polypeptide binding]; other site 697283003533 conserved gate region; other site 697283003534 putative PBP binding loops; other site 697283003535 ABC-ATPase subunit interface; other site 697283003536 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 697283003537 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 697283003538 Walker A/P-loop; other site 697283003539 ATP binding site [chemical binding]; other site 697283003540 Q-loop/lid; other site 697283003541 ABC transporter signature motif; other site 697283003542 Walker B; other site 697283003543 D-loop; other site 697283003544 H-loop/switch region; other site 697283003545 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 697283003546 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 697283003547 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 697283003548 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 697283003549 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 697283003550 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 697283003551 P loop; other site 697283003552 GTP binding site [chemical binding]; other site 697283003553 sugar phosphate phosphatase; Provisional; Region: PRK10513 697283003554 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697283003555 motif II; other site 697283003556 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 697283003557 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 697283003558 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697283003559 active site 697283003560 motif I; other site 697283003561 motif II; other site 697283003562 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 697283003563 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 697283003564 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 697283003565 Walker A/P-loop; other site 697283003566 ATP binding site [chemical binding]; other site 697283003567 Q-loop/lid; other site 697283003568 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 697283003569 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 697283003570 ABC transporter signature motif; other site 697283003571 Walker B; other site 697283003572 D-loop; other site 697283003573 H-loop/switch region; other site 697283003574 ribonuclease III; Reviewed; Region: rnc; PRK00102 697283003575 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 697283003576 dimerization interface [polypeptide binding]; other site 697283003577 active site 697283003578 metal binding site [ion binding]; metal-binding site 697283003579 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 697283003580 dsRNA binding site [nucleotide binding]; other site 697283003581 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 697283003582 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 697283003583 active site 697283003584 McrBC 5-methylcytosine restriction system component [Defense mechanisms]; Region: McrC; COG4268 697283003585 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 697283003586 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697283003587 Walker A motif; other site 697283003588 ATP binding site [chemical binding]; other site 697283003589 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 697283003590 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 697283003591 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 697283003592 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 697283003593 substrate binding site [chemical binding]; other site 697283003594 Predicted membrane protein [Function unknown]; Region: COG3326 697283003595 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 697283003596 tartrate dehydrogenase; Region: TTC; TIGR02089 697283003597 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 697283003598 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 697283003599 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 697283003600 DNA topoisomerase I; Validated; Region: PRK05582 697283003601 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 697283003602 active site 697283003603 interdomain interaction site; other site 697283003604 putative metal-binding site [ion binding]; other site 697283003605 nucleotide binding site [chemical binding]; other site 697283003606 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 697283003607 domain I; other site 697283003608 DNA binding groove [nucleotide binding] 697283003609 phosphate binding site [ion binding]; other site 697283003610 domain II; other site 697283003611 domain III; other site 697283003612 nucleotide binding site [chemical binding]; other site 697283003613 catalytic site [active] 697283003614 domain IV; other site 697283003615 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 697283003616 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 697283003617 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 697283003618 Predicted membrane protein [Function unknown]; Region: COG1808 697283003619 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 697283003620 DNA protecting protein DprA; Region: dprA; TIGR00732 697283003621 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 697283003622 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 697283003623 active site 697283003624 metal-binding site 697283003625 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 697283003626 active site 697283003627 ATP binding site [chemical binding]; other site 697283003628 Phosphotransferase enzyme family; Region: APH; pfam01636 697283003629 substrate binding site [chemical binding]; other site 697283003630 dimer interface [polypeptide binding]; other site 697283003631 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 697283003632 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 697283003633 putative NAD(P) binding site [chemical binding]; other site 697283003634 putative catalytic Zn binding site [ion binding]; other site 697283003635 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 697283003636 substrate binding site; other site 697283003637 dimer interface; other site 697283003638 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 697283003639 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 697283003640 LicD family; Region: LicD; cl01378 697283003641 LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475 697283003642 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 697283003643 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 697283003644 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 697283003645 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 697283003646 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 697283003647 ATP-grasp domain; Region: ATP-grasp_4; cl17255 697283003648 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 697283003649 IMP binding site; other site 697283003650 dimer interface [polypeptide binding]; other site 697283003651 interdomain contacts; other site 697283003652 partial ornithine binding site; other site 697283003653 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 697283003654 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 697283003655 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 697283003656 catalytic site [active] 697283003657 subunit interface [polypeptide binding]; other site 697283003658 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 697283003659 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 697283003660 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 697283003661 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 697283003662 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 697283003663 active site 697283003664 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 697283003665 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 697283003666 minor groove reading motif; other site 697283003667 helix-hairpin-helix signature motif; other site 697283003668 substrate binding pocket [chemical binding]; other site 697283003669 active site 697283003670 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 697283003671 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 697283003672 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 697283003673 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 697283003674 heat shock protein HtpX; Provisional; Region: PRK04897 697283003675 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 697283003676 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 697283003677 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697283003678 S-adenosylmethionine binding site [chemical binding]; other site 697283003679 uracil transporter; Provisional; Region: PRK10720 697283003680 signal recognition particle protein; Provisional; Region: PRK10867 697283003681 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 697283003682 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 697283003683 P loop; other site 697283003684 GTP binding site [chemical binding]; other site 697283003685 Signal peptide binding domain; Region: SRP_SPB; pfam02978 697283003686 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 697283003687 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 697283003688 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 697283003689 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 697283003690 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 697283003691 Zn2+ binding site [ion binding]; other site 697283003692 Mg2+ binding site [ion binding]; other site 697283003693 sugar phosphate phosphatase; Provisional; Region: PRK10513 697283003694 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697283003695 active site 697283003696 motif I; other site 697283003697 motif II; other site 697283003698 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697283003699 SAP domain; Region: SAP; pfam02037 697283003700 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 697283003701 camphor resistance protein CrcB; Provisional; Region: PRK14229 697283003702 camphor resistance protein CrcB; Provisional; Region: PRK14221 697283003703 hypothetical protein; Provisional; Region: PRK07248 697283003704 flavodoxin; Validated; Region: PRK07308 697283003705 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 697283003706 DHH family; Region: DHH; pfam01368 697283003707 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 697283003708 Winged helix-turn helix; Region: HTH_29; pfam13551 697283003709 Homeodomain-like domain; Region: HTH_32; pfam13565 697283003710 glutamate dehydrogenase; Provisional; Region: PRK09414 697283003711 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 697283003712 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 697283003713 NAD(P) binding site [chemical binding]; other site 697283003714 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697283003715 Walker A/P-loop; other site 697283003716 ATP binding site [chemical binding]; other site 697283003717 ABC transporter; Region: ABC_tran; pfam00005 697283003718 Q-loop/lid; other site 697283003719 ABC transporter signature motif; other site 697283003720 Walker B; other site 697283003721 D-loop; other site 697283003722 H-loop/switch region; other site 697283003723 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 697283003724 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 697283003725 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 697283003726 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 697283003727 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 697283003728 Class I aldolases; Region: Aldolase_Class_I; cl17187 697283003729 catalytic residue [active] 697283003730 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 697283003731 active site 697283003732 catalytic motif [active] 697283003733 Zn binding site [ion binding]; other site 697283003734 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 697283003735 tetramer interfaces [polypeptide binding]; other site 697283003736 binuclear metal-binding site [ion binding]; other site 697283003737 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 697283003738 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 697283003739 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 697283003740 Walker A/P-loop; other site 697283003741 ATP binding site [chemical binding]; other site 697283003742 Q-loop/lid; other site 697283003743 ABC transporter signature motif; other site 697283003744 Walker B; other site 697283003745 D-loop; other site 697283003746 H-loop/switch region; other site 697283003747 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 697283003748 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 697283003749 Walker A/P-loop; other site 697283003750 ATP binding site [chemical binding]; other site 697283003751 Q-loop/lid; other site 697283003752 ABC transporter signature motif; other site 697283003753 Walker B; other site 697283003754 D-loop; other site 697283003755 H-loop/switch region; other site 697283003756 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 697283003757 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 697283003758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283003759 dimer interface [polypeptide binding]; other site 697283003760 conserved gate region; other site 697283003761 putative PBP binding loops; other site 697283003762 ABC-ATPase subunit interface; other site 697283003763 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 697283003764 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283003765 dimer interface [polypeptide binding]; other site 697283003766 conserved gate region; other site 697283003767 putative PBP binding loops; other site 697283003768 ABC-ATPase subunit interface; other site 697283003769 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 697283003770 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 697283003771 cyclically-permuted mutarotase family protein; Region: mutarot_permut; TIGR03548 697283003772 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 697283003773 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 697283003774 putative active site cavity [active] 697283003775 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 697283003776 DDE superfamily endonuclease; Region: DDE_3; pfam13358 697283003777 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 697283003778 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 697283003779 CAAX protease self-immunity; Region: Abi; pfam02517 697283003780 Arsenate reductase and related proteins, glutaredoxin family [Inorganic ion transport and metabolism]; Region: ArsC; COG1393 697283003781 ArsC family; Region: ArsC; pfam03960 697283003782 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 697283003783 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 697283003784 cofactor binding site; other site 697283003785 DNA binding site [nucleotide binding] 697283003786 substrate interaction site [chemical binding]; other site 697283003787 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 697283003788 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 697283003789 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 697283003790 core dimer interface [polypeptide binding]; other site 697283003791 L10 interface [polypeptide binding]; other site 697283003792 L11 interface [polypeptide binding]; other site 697283003793 putative EF-Tu interaction site [polypeptide binding]; other site 697283003794 putative EF-G interaction site [polypeptide binding]; other site 697283003795 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 697283003796 23S rRNA interface [nucleotide binding]; other site 697283003797 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 697283003798 ribosomal protein L10 leader 697283003799 chlorohydrolase; Validated; Region: PRK06687 697283003800 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 697283003801 active site 697283003802 putative substrate binding pocket [chemical binding]; other site 697283003803 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 697283003804 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 697283003805 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 697283003806 Walker A/P-loop; other site 697283003807 ATP binding site [chemical binding]; other site 697283003808 Q-loop/lid; other site 697283003809 ABC transporter signature motif; other site 697283003810 Walker B; other site 697283003811 D-loop; other site 697283003812 H-loop/switch region; other site 697283003813 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 697283003814 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 697283003815 APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination; Region: APC10-like; cl02148 697283003816 putative ligand binding site [chemical binding]; other site 697283003817 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697283003818 Walker A/P-loop; other site 697283003819 ATP binding site [chemical binding]; other site 697283003820 Q-loop/lid; other site 697283003821 ABC transporter signature motif; other site 697283003822 Walker B; other site 697283003823 D-loop; other site 697283003824 H-loop/switch region; other site 697283003825 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 697283003826 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 697283003827 SelR domain; Region: SelR; pfam01641 697283003828 homoserine kinase; Provisional; Region: PRK01212 697283003829 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 697283003830 homoserine dehydrogenase; Provisional; Region: PRK06349 697283003831 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 697283003832 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 697283003833 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 697283003834 adaptor protein; Provisional; Region: PRK02315 697283003835 O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296 697283003836 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 697283003837 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 697283003838 active site 697283003839 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 697283003840 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 697283003841 putative ADP-binding pocket [chemical binding]; other site 697283003842 LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475 697283003843 Transcriptional regulator [Transcription]; Region: LytR; COG1316 697283003844 prephenate dehydratase; Provisional; Region: PRK11898 697283003845 Prephenate dehydratase; Region: PDT; pfam00800 697283003846 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 697283003847 putative L-Phe binding site [chemical binding]; other site 697283003848 shikimate kinase; Reviewed; Region: aroK; PRK00131 697283003849 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 697283003850 ADP binding site [chemical binding]; other site 697283003851 magnesium binding site [ion binding]; other site 697283003852 putative shikimate binding site; other site 697283003853 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 697283003854 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 697283003855 hinge; other site 697283003856 active site 697283003857 hypothetical protein; Provisional; Region: PRK13676 697283003858 prephenate dehydrogenase; Validated; Region: PRK06545 697283003859 prephenate dehydrogenase; Validated; Region: PRK08507 697283003860 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 697283003861 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 697283003862 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 697283003863 Tetramer interface [polypeptide binding]; other site 697283003864 active site 697283003865 FMN-binding site [chemical binding]; other site 697283003866 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 697283003867 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 697283003868 active site 697283003869 dimer interface [polypeptide binding]; other site 697283003870 metal binding site [ion binding]; metal-binding site 697283003871 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 697283003872 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 697283003873 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 697283003874 shikimate binding site; other site 697283003875 NAD(P) binding site [chemical binding]; other site 697283003876 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 697283003877 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 697283003878 active site 697283003879 catalytic residue [active] 697283003880 dimer interface [polypeptide binding]; other site 697283003881 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 697283003882 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 697283003883 putative RNA binding site [nucleotide binding]; other site 697283003884 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697283003885 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 697283003886 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 697283003887 Walker A/P-loop; other site 697283003888 ATP binding site [chemical binding]; other site 697283003889 Q-loop/lid; other site 697283003890 ABC transporter signature motif; other site 697283003891 Walker B; other site 697283003892 D-loop; other site 697283003893 H-loop/switch region; other site 697283003894 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 697283003895 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 697283003896 active site 697283003897 Na/Ca binding site [ion binding]; other site 697283003898 catalytic site [active] 697283003899 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 697283003900 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 697283003901 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 697283003902 motif 1; other site 697283003903 active site 697283003904 motif 2; other site 697283003905 motif 3; other site 697283003906 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 697283003907 DHHA1 domain; Region: DHHA1; pfam02272 697283003908 Uncharacterized conserved protein [Function unknown]; Region: COG4894 697283003909 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 697283003910 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 697283003911 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 697283003912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283003913 dimer interface [polypeptide binding]; other site 697283003914 conserved gate region; other site 697283003915 putative PBP binding loops; other site 697283003916 ABC-ATPase subunit interface; other site 697283003917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283003918 dimer interface [polypeptide binding]; other site 697283003919 conserved gate region; other site 697283003920 putative PBP binding loops; other site 697283003921 ABC-ATPase subunit interface; other site 697283003922 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 697283003923 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 697283003924 Walker A/P-loop; other site 697283003925 ATP binding site [chemical binding]; other site 697283003926 Q-loop/lid; other site 697283003927 ABC transporter signature motif; other site 697283003928 Walker B; other site 697283003929 D-loop; other site 697283003930 H-loop/switch region; other site 697283003931 TOBE domain; Region: TOBE_2; pfam08402 697283003932 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 697283003933 FAD binding domain; Region: FAD_binding_4; pfam01565 697283003934 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 697283003935 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 697283003936 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 697283003937 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 697283003938 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 697283003939 DNA-binding site [nucleotide binding]; DNA binding site 697283003940 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 697283003941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697283003942 homodimer interface [polypeptide binding]; other site 697283003943 catalytic residue [active] 697283003944 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 697283003945 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 697283003946 substrate binding pocket [chemical binding]; other site 697283003947 membrane-bound complex binding site; other site 697283003948 hinge residues; other site 697283003949 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 697283003950 PhoU domain; Region: PhoU; pfam01895 697283003951 PhoU domain; Region: PhoU; pfam01895 697283003952 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 697283003953 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 697283003954 Walker A/P-loop; other site 697283003955 ATP binding site [chemical binding]; other site 697283003956 Q-loop/lid; other site 697283003957 ABC transporter signature motif; other site 697283003958 Walker B; other site 697283003959 D-loop; other site 697283003960 H-loop/switch region; other site 697283003961 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 697283003962 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 697283003963 Walker A/P-loop; other site 697283003964 ATP binding site [chemical binding]; other site 697283003965 Q-loop/lid; other site 697283003966 ABC transporter signature motif; other site 697283003967 Walker B; other site 697283003968 D-loop; other site 697283003969 H-loop/switch region; other site 697283003970 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 697283003971 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283003972 dimer interface [polypeptide binding]; other site 697283003973 conserved gate region; other site 697283003974 putative PBP binding loops; other site 697283003975 ABC-ATPase subunit interface; other site 697283003976 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 697283003977 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283003978 dimer interface [polypeptide binding]; other site 697283003979 conserved gate region; other site 697283003980 putative PBP binding loops; other site 697283003981 ABC-ATPase subunit interface; other site 697283003982 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 697283003983 phosphate binding protein; Region: ptsS_2; TIGR02136 697283003984 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 697283003985 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697283003986 S-adenosylmethionine binding site [chemical binding]; other site 697283003987 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 697283003988 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 697283003989 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 697283003990 active site 697283003991 hypothetical protein; Provisional; Region: PRK04387 697283003992 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 697283003993 ArsC family; Region: ArsC; pfam03960 697283003994 putative catalytic residues [active] 697283003995 thiol/disulfide switch; other site 697283003996 Predicted membrane protein [Function unknown]; Region: COG4478 697283003997 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 697283003998 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697283003999 active site 697283004000 motif I; other site 697283004001 motif II; other site 697283004002 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697283004003 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 697283004004 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 697283004005 active site 697283004006 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 697283004007 active site 697283004008 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 697283004009 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697283004010 FeS/SAM binding site; other site 697283004011 HemN C-terminal domain; Region: HemN_C; pfam06969 697283004012 YtxH-like protein; Region: YtxH; pfam12732 697283004013 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 697283004014 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 697283004015 HPr kinase/phosphorylase; Provisional; Region: PRK05428 697283004016 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 697283004017 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 697283004018 Hpr binding site; other site 697283004019 active site 697283004020 homohexamer subunit interaction site [polypeptide binding]; other site 697283004021 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 697283004022 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 697283004023 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 697283004024 active site 697283004025 trimer interface [polypeptide binding]; other site 697283004026 allosteric site; other site 697283004027 active site lid [active] 697283004028 hexamer (dimer of trimers) interface [polypeptide binding]; other site 697283004029 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 697283004030 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 697283004031 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 697283004032 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 697283004033 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 697283004034 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 697283004035 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 697283004036 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 697283004037 homodimer interface [polypeptide binding]; other site 697283004038 NAD binding pocket [chemical binding]; other site 697283004039 ATP binding pocket [chemical binding]; other site 697283004040 Mg binding site [ion binding]; other site 697283004041 active-site loop [active] 697283004042 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 697283004043 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 697283004044 active site 697283004045 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697283004046 non-specific DNA binding site [nucleotide binding]; other site 697283004047 salt bridge; other site 697283004048 sequence-specific DNA binding site [nucleotide binding]; other site 697283004049 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697283004050 ABC transporter; Region: ABC_tran; pfam00005 697283004051 Q-loop/lid; other site 697283004052 ABC transporter signature motif; other site 697283004053 Walker B; other site 697283004054 D-loop; other site 697283004055 H-loop/switch region; other site 697283004056 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 697283004057 Peptidase family U32; Region: Peptidase_U32; pfam01136 697283004058 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 697283004059 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 697283004060 Peptidase family U32; Region: Peptidase_U32; pfam01136 697283004061 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 697283004062 ApaLI-like restriction endonuclease; Region: RE_ApaLI; pfam09499 697283004063 ApaLI-like restriction endonuclease; Region: RE_ApaLI; pfam09499 697283004064 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 697283004065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697283004066 S-adenosylmethionine binding site [chemical binding]; other site 697283004067 Helix-turn-helix domain; Region: HTH_18; pfam12833 697283004068 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 697283004069 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 697283004070 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 697283004071 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697283004072 Walker A/P-loop; other site 697283004073 ATP binding site [chemical binding]; other site 697283004074 Q-loop/lid; other site 697283004075 ABC transporter signature motif; other site 697283004076 Walker B; other site 697283004077 D-loop; other site 697283004078 H-loop/switch region; other site 697283004079 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 697283004080 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697283004081 Walker A/P-loop; other site 697283004082 ATP binding site [chemical binding]; other site 697283004083 Q-loop/lid; other site 697283004084 ABC transporter signature motif; other site 697283004085 Walker B; other site 697283004086 D-loop; other site 697283004087 H-loop/switch region; other site 697283004088 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 697283004089 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 697283004090 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 697283004091 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 697283004092 Walker A/P-loop; other site 697283004093 ATP binding site [chemical binding]; other site 697283004094 Q-loop/lid; other site 697283004095 ABC transporter signature motif; other site 697283004096 Walker B; other site 697283004097 D-loop; other site 697283004098 H-loop/switch region; other site 697283004099 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697283004100 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 697283004101 Walker A/P-loop; other site 697283004102 ATP binding site [chemical binding]; other site 697283004103 Q-loop/lid; other site 697283004104 ABC transporter signature motif; other site 697283004105 Walker B; other site 697283004106 D-loop; other site 697283004107 H-loop/switch region; other site 697283004108 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 697283004109 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 697283004110 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 697283004111 GMP synthase; Reviewed; Region: guaA; PRK00074 697283004112 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 697283004113 AMP/PPi binding site [chemical binding]; other site 697283004114 candidate oxyanion hole; other site 697283004115 catalytic triad [active] 697283004116 potential glutamine specificity residues [chemical binding]; other site 697283004117 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 697283004118 ATP Binding subdomain [chemical binding]; other site 697283004119 Dimerization subdomain; other site 697283004120 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 697283004121 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 697283004122 DNA-binding site [nucleotide binding]; DNA binding site 697283004123 UTRA domain; Region: UTRA; pfam07702 697283004124 EamA-like transporter family; Region: EamA; pfam00892 697283004125 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 697283004126 Beta-lactamase; Region: Beta-lactamase; pfam00144 697283004127 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 697283004128 active site 697283004129 catalytic triad [active] 697283004130 oxyanion hole [active] 697283004131 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 697283004132 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697283004133 active site 697283004134 motif I; other site 697283004135 motif II; other site 697283004136 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697283004137 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 697283004138 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 697283004139 putative active site [active] 697283004140 putative metal binding site [ion binding]; other site 697283004141 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 697283004142 active site 697283004143 catalytic residues [active] 697283004144 metal binding site [ion binding]; metal-binding site 697283004145 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 697283004146 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 697283004147 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 697283004148 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 697283004149 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 697283004150 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 697283004151 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 697283004152 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 697283004153 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 697283004154 Walker A/P-loop; other site 697283004155 ATP binding site [chemical binding]; other site 697283004156 Q-loop/lid; other site 697283004157 ABC transporter signature motif; other site 697283004158 Walker B; other site 697283004159 D-loop; other site 697283004160 H-loop/switch region; other site 697283004161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 697283004162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283004163 ABC-ATPase subunit interface; other site 697283004164 putative PBP binding loops; other site 697283004165 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 697283004166 putative ArsC-like catalytic residues; other site 697283004167 putative TRX-like catalytic residues [active] 697283004168 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 697283004169 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 697283004170 DNA binding site [nucleotide binding] 697283004171 active site 697283004172 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 697283004173 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 697283004174 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 697283004175 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 697283004176 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 697283004177 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 697283004178 predicted active site [active] 697283004179 catalytic triad [active] 697283004180 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 697283004181 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 697283004182 active site 697283004183 multimer interface [polypeptide binding]; other site 697283004184 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 697283004185 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 697283004186 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 697283004187 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 697283004188 ApbE family; Region: ApbE; pfam02424 697283004189 Predicted flavoprotein [General function prediction only]; Region: COG0431 697283004190 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 697283004191 Predicted flavoprotein [General function prediction only]; Region: COG0431 697283004192 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 697283004193 PAS domain; Region: PAS_10; pfam13596 697283004194 hypothetical protein; Provisional; Region: PRK02539 697283004195 Glycyl-tRNA synthetase, beta subunit [Translation, ribosomal structure and biogenesis]; Region: GlyS; COG0751 697283004196 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 697283004197 DALR anticodon binding domain; Region: DALR_1; pfam05746 697283004198 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 697283004199 dimer interface [polypeptide binding]; other site 697283004200 motif 1; other site 697283004201 active site 697283004202 motif 2; other site 697283004203 motif 3; other site 697283004204 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 697283004205 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 697283004206 active site 697283004207 catalytic tetrad [active] 697283004208 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 697283004209 Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947 697283004210 NodB motif; other site 697283004211 active site 697283004212 catalytic site [active] 697283004213 Zn binding site [ion binding]; other site 697283004214 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 697283004215 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 697283004216 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 697283004217 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 697283004218 DEAD-like helicases superfamily; Region: DEXDc; smart00487 697283004219 ATP binding site [chemical binding]; other site 697283004220 putative Mg++ binding site [ion binding]; other site 697283004221 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 697283004222 nucleotide binding region [chemical binding]; other site 697283004223 ATP-binding site [chemical binding]; other site 697283004224 DDE superfamily endonuclease; Region: DDE_3; pfam13358 697283004225 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 697283004226 Homeodomain-like domain; Region: HTH_23; pfam13384 697283004227 Winged helix-turn helix; Region: HTH_29; pfam13551 697283004228 Homeodomain-like domain; Region: HTH_32; pfam13565 697283004229 elongation factor Tu; Reviewed; Region: PRK00049 697283004230 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 697283004231 G1 box; other site 697283004232 GEF interaction site [polypeptide binding]; other site 697283004233 GTP/Mg2+ binding site [chemical binding]; other site 697283004234 Switch I region; other site 697283004235 G2 box; other site 697283004236 G3 box; other site 697283004237 Switch II region; other site 697283004238 G4 box; other site 697283004239 G5 box; other site 697283004240 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 697283004241 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 697283004242 Antibiotic Binding Site [chemical binding]; other site 697283004243 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 697283004244 amphipathic channel; other site 697283004245 Asn-Pro-Ala signature motifs; other site 697283004246 MucBP domain; Region: MucBP; pfam06458 697283004247 DDE superfamily endonuclease; Region: DDE_3; pfam13358 697283004248 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 697283004249 Transposase; Region: HTH_Tnp_IS630; pfam01710 697283004250 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 697283004251 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 697283004252 active site 697283004253 substrate binding site [chemical binding]; other site 697283004254 metal binding site [ion binding]; metal-binding site 697283004255 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 697283004256 catalytic residues [active] 697283004257 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 697283004258 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 697283004259 substrate binding pocket [chemical binding]; other site 697283004260 membrane-bound complex binding site; other site 697283004261 hinge residues; other site 697283004262 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 697283004263 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697283004264 Walker A/P-loop; other site 697283004265 ATP binding site [chemical binding]; other site 697283004266 Q-loop/lid; other site 697283004267 ABC transporter signature motif; other site 697283004268 Walker B; other site 697283004269 D-loop; other site 697283004270 H-loop/switch region; other site 697283004271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283004272 dimer interface [polypeptide binding]; other site 697283004273 conserved gate region; other site 697283004274 putative PBP binding loops; other site 697283004275 ABC-ATPase subunit interface; other site 697283004276 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 697283004277 TPR motif; other site 697283004278 binding surface 697283004279 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 697283004280 binding surface 697283004281 TPR motif; other site 697283004282 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 697283004283 Domain of unknown function DUF20; Region: UPF0118; pfam01594 697283004284 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 697283004285 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 697283004286 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 697283004287 gamma subunit interface [polypeptide binding]; other site 697283004288 epsilon subunit interface [polypeptide binding]; other site 697283004289 LBP interface [polypeptide binding]; other site 697283004290 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 697283004291 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 697283004292 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 697283004293 alpha subunit interaction interface [polypeptide binding]; other site 697283004294 Walker A motif; other site 697283004295 ATP binding site [chemical binding]; other site 697283004296 Walker B motif; other site 697283004297 inhibitor binding site; inhibition site 697283004298 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 697283004299 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 697283004300 core domain interface [polypeptide binding]; other site 697283004301 delta subunit interface [polypeptide binding]; other site 697283004302 epsilon subunit interface [polypeptide binding]; other site 697283004303 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 697283004304 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 697283004305 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 697283004306 beta subunit interaction interface [polypeptide binding]; other site 697283004307 Walker A motif; other site 697283004308 ATP binding site [chemical binding]; other site 697283004309 Walker B motif; other site 697283004310 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 697283004311 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 697283004312 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 697283004313 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 697283004314 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 697283004315 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 697283004316 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 697283004317 F0F1 ATP synthase subunit C; Provisional; Region: PRK13467 697283004318 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 697283004319 Helix-turn-helix domain; Region: HTH_38; pfam13936 697283004320 Integrase core domain; Region: rve; pfam00665 697283004321 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697283004322 Coenzyme A binding pocket [chemical binding]; other site 697283004323 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 697283004324 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 697283004325 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 697283004326 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 697283004327 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 697283004328 dimerization interface [polypeptide binding]; other site 697283004329 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 697283004330 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697283004331 Coenzyme A binding pocket [chemical binding]; other site 697283004332 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697283004333 Coenzyme A binding pocket [chemical binding]; other site 697283004334 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 697283004335 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 697283004336 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 697283004337 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 697283004338 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 697283004339 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 697283004340 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 697283004341 ATP binding site [chemical binding]; other site 697283004342 putative Mg++ binding site [ion binding]; other site 697283004343 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 697283004344 nucleotide binding region [chemical binding]; other site 697283004345 ATP-binding site [chemical binding]; other site 697283004346 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 697283004347 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 697283004348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697283004349 homodimer interface [polypeptide binding]; other site 697283004350 catalytic residue [active] 697283004351 cystathionine gamma-synthase; Reviewed; Region: PRK07269 697283004352 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 697283004353 homodimer interface [polypeptide binding]; other site 697283004354 substrate-cofactor binding pocket; other site 697283004355 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697283004356 catalytic residue [active] 697283004357 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 697283004358 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697283004359 Walker A/P-loop; other site 697283004360 ATP binding site [chemical binding]; other site 697283004361 Q-loop/lid; other site 697283004362 ABC transporter signature motif; other site 697283004363 Walker B; other site 697283004364 D-loop; other site 697283004365 H-loop/switch region; other site 697283004366 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 697283004367 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 697283004368 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 697283004369 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 697283004370 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 697283004371 peptide binding site [polypeptide binding]; other site 697283004372 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 697283004373 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 697283004374 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 697283004375 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 697283004376 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 697283004377 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 697283004378 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 697283004379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 697283004380 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 697283004381 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 697283004382 DHH family; Region: DHH; pfam01368 697283004383 DHHA2 domain; Region: DHHA2; pfam02833 697283004384 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 697283004385 GIY-YIG motif/motif A; other site 697283004386 putative active site [active] 697283004387 putative metal binding site [ion binding]; other site 697283004388 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 697283004389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697283004390 S-adenosylmethionine binding site [chemical binding]; other site 697283004391 hypothetical protein; Provisional; Region: PRK07252 697283004392 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 697283004393 RNA binding site [nucleotide binding]; other site 697283004394 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697283004395 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 697283004396 active site 697283004397 motif I; other site 697283004398 motif II; other site 697283004399 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697283004400 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 697283004401 active site 697283004402 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 697283004403 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 697283004404 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 697283004405 dimer interface [polypeptide binding]; other site 697283004406 ssDNA binding site [nucleotide binding]; other site 697283004407 tetramer (dimer of dimers) interface [polypeptide binding]; other site 697283004408 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 697283004409 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 697283004410 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 697283004411 putative dimer interface [polypeptide binding]; other site 697283004412 putative anticodon binding site; other site 697283004413 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 697283004414 homodimer interface [polypeptide binding]; other site 697283004415 motif 1; other site 697283004416 motif 2; other site 697283004417 active site 697283004418 motif 3; other site 697283004419 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 697283004420 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 697283004421 aspartate aminotransferase; Provisional; Region: PRK05764 697283004422 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 697283004423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697283004424 homodimer interface [polypeptide binding]; other site 697283004425 catalytic residue [active] 697283004426 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 697283004427 Predicted flavoprotein [General function prediction only]; Region: COG0431 697283004428 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 697283004429 hypothetical protein; Validated; Region: PRK02101 697283004430 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 697283004431 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 697283004432 active site 697283004433 catalytic residues [active] 697283004434 metal binding site [ion binding]; metal-binding site 697283004435 putative S-transferase; Provisional; Region: PRK11752 697283004436 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 697283004437 C-terminal domain interface [polypeptide binding]; other site 697283004438 GSH binding site (G-site) [chemical binding]; other site 697283004439 dimer interface [polypeptide binding]; other site 697283004440 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 697283004441 N-terminal domain interface [polypeptide binding]; other site 697283004442 dimer interface [polypeptide binding]; other site 697283004443 substrate binding pocket (H-site) [chemical binding]; other site 697283004444 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 697283004445 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 697283004446 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 697283004447 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 697283004448 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 697283004449 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 697283004450 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 697283004451 Cation efflux family; Region: Cation_efflux; pfam01545 697283004452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 697283004453 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 697283004454 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697283004455 Walker A/P-loop; other site 697283004456 ATP binding site [chemical binding]; other site 697283004457 Q-loop/lid; other site 697283004458 ABC transporter signature motif; other site 697283004459 Walker B; other site 697283004460 D-loop; other site 697283004461 H-loop/switch region; other site 697283004462 ABC transporter; Region: ABC_tran_2; pfam12848 697283004463 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 697283004464 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 697283004465 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 697283004466 active site 697283004467 NTP binding site [chemical binding]; other site 697283004468 metal binding triad [ion binding]; metal-binding site 697283004469 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 697283004470 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 697283004471 dihydrodipicolinate reductase; Provisional; Region: PRK00048 697283004472 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 697283004473 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 697283004474 EDD domain protein, DegV family; Region: DegV; TIGR00762 697283004475 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 697283004476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835 697283004477 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 697283004478 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 697283004479 active site 697283004480 substrate binding site [chemical binding]; other site 697283004481 metal binding site [ion binding]; metal-binding site 697283004482 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 697283004483 YbbR-like protein; Region: YbbR; pfam07949 697283004484 Uncharacterized conserved protein [Function unknown]; Region: COG1624 697283004485 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 697283004486 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 697283004487 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 697283004488 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 697283004489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 697283004490 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 697283004491 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 697283004492 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 697283004493 dimer interface [polypeptide binding]; other site 697283004494 phosphate binding site [ion binding]; other site 697283004495 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 697283004496 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 697283004497 homotrimer interaction site [polypeptide binding]; other site 697283004498 putative active site [active] 697283004499 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 697283004500 G1 box; other site 697283004501 GTP/Mg2+ binding site [chemical binding]; other site 697283004502 Switch I region; other site 697283004503 G2 box; other site 697283004504 G3 box; other site 697283004505 Switch II region; other site 697283004506 G4 box; other site 697283004507 G5 box; other site 697283004508 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 697283004509 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 697283004510 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697283004511 Walker A motif; other site 697283004512 ATP binding site [chemical binding]; other site 697283004513 Walker B motif; other site 697283004514 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 697283004515 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 697283004516 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 697283004517 folate binding site [chemical binding]; other site 697283004518 NADP+ binding site [chemical binding]; other site 697283004519 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 697283004520 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 697283004521 dimerization interface [polypeptide binding]; other site 697283004522 DPS ferroxidase diiron center [ion binding]; other site 697283004523 ion pore; other site 697283004524 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 697283004525 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 697283004526 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 697283004527 active site 697283004528 triosephosphate isomerase; Provisional; Region: PRK14567 697283004529 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 697283004530 substrate binding site [chemical binding]; other site 697283004531 dimer interface [polypeptide binding]; other site 697283004532 catalytic triad [active] 697283004533 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 697283004534 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 697283004535 Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897 697283004536 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 697283004537 proposed active site lysine [active] 697283004538 conserved cys residue [active] 697283004539 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 697283004540 active site 697283004541 Methyltransferase domain; Region: Methyltransf_31; pfam13847 697283004542 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697283004543 S-adenosylmethionine binding site [chemical binding]; other site 697283004544 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 697283004545 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 697283004546 Walker A/P-loop; other site 697283004547 ATP binding site [chemical binding]; other site 697283004548 Q-loop/lid; other site 697283004549 ABC transporter signature motif; other site 697283004550 Walker B; other site 697283004551 D-loop; other site 697283004552 H-loop/switch region; other site 697283004553 TOBE domain; Region: TOBE_2; pfam08402 697283004554 Isochorismatase family; Region: Isochorismatase; pfam00857 697283004555 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 697283004556 catalytic triad [active] 697283004557 conserved cis-peptide bond; other site 697283004558 Pleiotropic transcriptional repressor [Transcription]; Region: CodY; COG4465 697283004559 CodY GAF-like domain; Region: CodY; pfam06018 697283004560 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 697283004561 putative DNA binding site [nucleotide binding]; other site 697283004562 putative Zn2+ binding site [ion binding]; other site 697283004563 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 697283004564 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 697283004565 ATP binding site [chemical binding]; other site 697283004566 Mg++ binding site [ion binding]; other site 697283004567 motif III; other site 697283004568 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 697283004569 nucleotide binding region [chemical binding]; other site 697283004570 ATP-binding site [chemical binding]; other site 697283004571 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 697283004572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697283004573 putative substrate translocation pore; other site 697283004574 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 697283004575 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 697283004576 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 697283004577 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 697283004578 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 697283004579 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 697283004580 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 697283004581 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 697283004582 catalytic triad [active] 697283004583 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 697283004584 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 697283004585 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 697283004586 active site 697283004587 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 697283004588 Integrase core domain; Region: rve; pfam00665 697283004589 Integrase core domain; Region: rve_2; pfam13333 697283004590 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697283004591 Helix-turn-helix domain; Region: HTH_28; pfam13518 697283004592 Predicted membrane protein [Function unknown]; Region: COG4720 697283004593 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 697283004594 dimer interface [polypeptide binding]; other site 697283004595 substrate binding site [chemical binding]; other site 697283004596 ATP binding site [chemical binding]; other site 697283004597 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 697283004598 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 697283004599 dimerization interface 3.5A [polypeptide binding]; other site 697283004600 active site 697283004601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697283004602 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 697283004603 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 697283004604 PhnA protein; Region: PhnA; pfam03831 697283004605 cytidylate kinase; Provisional; Region: cmk; PRK00023 697283004606 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 697283004607 CMP-binding site; other site 697283004608 The sites determining sugar specificity; other site 697283004609 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 697283004610 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 697283004611 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 697283004612 Ligand binding site; other site 697283004613 Putative Catalytic site; other site 697283004614 DXD motif; other site 697283004615 UDP-glucose 4-epimerase; Region: PLN02240 697283004616 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 697283004617 NAD binding site [chemical binding]; other site 697283004618 homodimer interface [polypeptide binding]; other site 697283004619 active site 697283004620 substrate binding site [chemical binding]; other site 697283004621 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 697283004622 Uncharacterized conserved protein [Function unknown]; Region: COG0327 697283004623 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 697283004624 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 697283004625 Family of unknown function (DUF633); Region: DUF633; pfam04816 697283004626 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 697283004627 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 697283004628 active site 697283004629 ATP binding site [chemical binding]; other site 697283004630 Integrase core domain; Region: rve; pfam00665 697283004631 Integrase core domain; Region: rve_2; pfam13333 697283004632 HTH-like domain; Region: HTH_21; pfam13276 697283004633 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697283004634 Helix-turn-helix domain; Region: HTH_28; pfam13518 697283004635 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 697283004636 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 697283004637 TPP-binding site [chemical binding]; other site 697283004638 dimer interface [polypeptide binding]; other site 697283004639 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 697283004640 PYR/PP interface [polypeptide binding]; other site 697283004641 dimer interface [polypeptide binding]; other site 697283004642 TPP binding site [chemical binding]; other site 697283004643 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 697283004644 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 697283004645 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 697283004646 substrate binding site [chemical binding]; other site 697283004647 hexamer interface [polypeptide binding]; other site 697283004648 metal binding site [ion binding]; metal-binding site 697283004649 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 697283004650 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 697283004651 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 697283004652 active site 697283004653 P-loop; other site 697283004654 phosphorylation site [posttranslational modification] 697283004655 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 697283004656 active site 697283004657 phosphorylation site [posttranslational modification] 697283004658 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 697283004659 active site 697283004660 phosphorylation site [posttranslational modification] 697283004661 HTH domain; Region: HTH_11; pfam08279 697283004662 Mga helix-turn-helix domain; Region: Mga; pfam05043 697283004663 PRD domain; Region: PRD; pfam00874 697283004664 PRD domain; Region: PRD; pfam00874 697283004665 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 697283004666 active site 697283004667 P-loop; other site 697283004668 phosphorylation site [posttranslational modification] 697283004669 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 697283004670 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 697283004671 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 697283004672 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697283004673 motif II; other site 697283004674 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 697283004675 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 697283004676 putative acyl-acceptor binding pocket; other site 697283004677 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 697283004678 Cadmium resistance transporter; Region: Cad; pfam03596 697283004679 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 697283004680 16S/18S rRNA binding site [nucleotide binding]; other site 697283004681 S13e-L30e interaction site [polypeptide binding]; other site 697283004682 25S rRNA binding site [nucleotide binding]; other site 697283004683 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 697283004684 NADH(P)-binding; Region: NAD_binding_10; pfam13460 697283004685 NAD binding site [chemical binding]; other site 697283004686 substrate binding site [chemical binding]; other site 697283004687 putative active site [active] 697283004688 T-box leader 697283004689 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 697283004690 metal binding site [ion binding]; metal-binding site 697283004691 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 697283004692 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 697283004693 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 697283004694 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 697283004695 active site 697283004696 dimer interface [polypeptide binding]; other site 697283004697 motif 1; other site 697283004698 motif 2; other site 697283004699 motif 3; other site 697283004700 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 697283004701 anticodon binding site; other site 697283004702 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 697283004703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697283004704 ATP binding site [chemical binding]; other site 697283004705 Mg2+ binding site [ion binding]; other site 697283004706 G-X-G motif; other site 697283004707 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 697283004708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697283004709 active site 697283004710 phosphorylation site [posttranslational modification] 697283004711 intermolecular recognition site; other site 697283004712 dimerization interface [polypeptide binding]; other site 697283004713 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 697283004714 DNA binding site [nucleotide binding] 697283004715 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 697283004716 nucleophilic elbow; other site 697283004717 catalytic triad; other site 697283004718 Predicted transcriptional regulator [Transcription]; Region: COG1959 697283004719 Transcriptional regulator; Region: Rrf2; pfam02082 697283004720 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 697283004721 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 697283004722 active site 697283004723 metal binding site [ion binding]; metal-binding site 697283004724 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 697283004725 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 697283004726 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 697283004727 FeoA domain; Region: FeoA; pfam04023 697283004728 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 697283004729 putative active site [active] 697283004730 dimerization interface [polypeptide binding]; other site 697283004731 putative tRNAtyr binding site [nucleotide binding]; other site 697283004732 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 697283004733 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 697283004734 Zn2+ binding site [ion binding]; other site 697283004735 Mg2+ binding site [ion binding]; other site 697283004736 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 697283004737 synthetase active site [active] 697283004738 NTP binding site [chemical binding]; other site 697283004739 metal binding site [ion binding]; metal-binding site 697283004740 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 697283004741 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 697283004742 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 697283004743 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 697283004744 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 697283004745 active site 697283004746 Zn binding site [ion binding]; other site 697283004747 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 697283004748 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 697283004749 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 697283004750 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 697283004751 ABC-ATPase subunit interface; other site 697283004752 dimer interface [polypeptide binding]; other site 697283004753 putative PBP binding regions; other site 697283004754 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 697283004755 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 697283004756 metal binding site [ion binding]; metal-binding site 697283004757 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 697283004758 dimer interface [polypeptide binding]; other site 697283004759 catalytic triad [active] 697283004760 peroxidatic and resolving cysteines [active] 697283004761 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 697283004762 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 697283004763 Walker A/P-loop; other site 697283004764 ATP binding site [chemical binding]; other site 697283004765 Q-loop/lid; other site 697283004766 ABC transporter signature motif; other site 697283004767 Walker B; other site 697283004768 D-loop; other site 697283004769 H-loop/switch region; other site 697283004770 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 697283004771 catalytic core [active] 697283004772 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 697283004773 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 697283004774 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 697283004775 active site 697283004776 HIGH motif; other site 697283004777 nucleotide binding site [chemical binding]; other site 697283004778 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 697283004779 active site 697283004780 KMSKS motif; other site 697283004781 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 697283004782 tRNA binding surface [nucleotide binding]; other site 697283004783 anticodon binding site; other site 697283004784 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 697283004785 T-box leader 697283004786 DivIVA domain; Region: DivI1A_domain; TIGR03544 697283004787 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 697283004788 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 697283004789 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 697283004790 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 697283004791 RNA binding surface [nucleotide binding]; other site 697283004792 YGGT family; Region: YGGT; pfam02325 697283004793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 697283004794 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 697283004795 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 697283004796 catalytic residue [active] 697283004797 cell division protein FtsZ; Validated; Region: PRK09330 697283004798 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 697283004799 nucleotide binding site [chemical binding]; other site 697283004800 SulA interaction site; other site 697283004801 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 697283004802 Cell division protein FtsA; Region: FtsA; smart00842 697283004803 Cell division protein FtsA; Region: FtsA; pfam14450 697283004804 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 697283004805 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 697283004806 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 697283004807 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 697283004808 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 697283004809 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 697283004810 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 697283004811 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 697283004812 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 697283004813 recombination protein RecR; Reviewed; Region: recR; PRK00076 697283004814 RecR protein; Region: RecR; pfam02132 697283004815 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 697283004816 putative active site [active] 697283004817 putative metal-binding site [ion binding]; other site 697283004818 tetramer interface [polypeptide binding]; other site 697283004819 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 697283004820 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 697283004821 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 697283004822 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 697283004823 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 697283004824 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 697283004825 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 697283004826 putative active site [active] 697283004827 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 697283004828 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 697283004829 nucleotide binding site [chemical binding]; other site 697283004830 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 697283004831 Class I aldolases; Region: Aldolase_Class_I; cl17187 697283004832 catalytic residue [active] 697283004833 Protein of unknown function, DUF624; Region: DUF624; pfam04854 697283004834 Domain of unknown function (DUF386); Region: DUF386; pfam04074 697283004835 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 697283004836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283004837 dimer interface [polypeptide binding]; other site 697283004838 conserved gate region; other site 697283004839 putative PBP binding loops; other site 697283004840 ABC-ATPase subunit interface; other site 697283004841 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 697283004842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 697283004843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283004844 putative PBP binding loops; other site 697283004845 dimer interface [polypeptide binding]; other site 697283004846 ABC-ATPase subunit interface; other site 697283004847 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 697283004848 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 697283004849 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 697283004850 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 697283004851 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 697283004852 active site turn [active] 697283004853 phosphorylation site [posttranslational modification] 697283004854 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 697283004855 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 697283004856 putative active site cavity [active] 697283004857 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 697283004858 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 697283004859 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 697283004860 Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409 697283004861 Sialidase, N-terminal domain; Region: Sialidase; pfam02973 697283004862 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 697283004863 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 697283004864 Asp-box motif; other site 697283004865 catalytic site [active] 697283004866 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 697283004867 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283004868 dimer interface [polypeptide binding]; other site 697283004869 conserved gate region; other site 697283004870 putative PBP binding loops; other site 697283004871 ABC-ATPase subunit interface; other site 697283004872 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 697283004873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283004874 dimer interface [polypeptide binding]; other site 697283004875 conserved gate region; other site 697283004876 putative PBP binding loops; other site 697283004877 ABC-ATPase subunit interface; other site 697283004878 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 697283004879 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 697283004880 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 697283004881 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 697283004882 Sialidase, N-terminal domain; Region: Sialidase; pfam02973 697283004883 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 697283004884 catalytic site [active] 697283004885 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 697283004886 Asp-box motif; other site 697283004887 Asp-box motif; other site 697283004888 catalytic site [active] 697283004889 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 697283004890 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 697283004891 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 697283004892 ssDNA binding site; other site 697283004893 generic binding surface II; other site 697283004894 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 697283004895 ATP binding site [chemical binding]; other site 697283004896 putative Mg++ binding site [ion binding]; other site 697283004897 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 697283004898 nucleotide binding region [chemical binding]; other site 697283004899 ATP-binding site [chemical binding]; other site 697283004900 alanine racemase; Reviewed; Region: alr; PRK00053 697283004901 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 697283004902 active site 697283004903 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 697283004904 dimer interface [polypeptide binding]; other site 697283004905 substrate binding site [chemical binding]; other site 697283004906 catalytic residues [active] 697283004907 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 697283004908 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722 697283004909 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 697283004910 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722 697283004911 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 697283004912 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 697283004913 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 697283004914 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 697283004915 nucleotide binding region [chemical binding]; other site 697283004916 ATP-binding site [chemical binding]; other site 697283004917 SEC-C motif; Region: SEC-C; pfam02810 697283004918 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 697283004919 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 697283004920 Walker A/P-loop; other site 697283004921 ATP binding site [chemical binding]; other site 697283004922 Q-loop/lid; other site 697283004923 ABC transporter signature motif; other site 697283004924 Walker B; other site 697283004925 D-loop; other site 697283004926 H-loop/switch region; other site 697283004927 GTP-binding protein Der; Reviewed; Region: PRK00093 697283004928 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 697283004929 G1 box; other site 697283004930 GTP/Mg2+ binding site [chemical binding]; other site 697283004931 Switch I region; other site 697283004932 G2 box; other site 697283004933 Switch II region; other site 697283004934 G3 box; other site 697283004935 G4 box; other site 697283004936 G5 box; other site 697283004937 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 697283004938 G1 box; other site 697283004939 GTP/Mg2+ binding site [chemical binding]; other site 697283004940 Switch I region; other site 697283004941 G2 box; other site 697283004942 G3 box; other site 697283004943 Switch II region; other site 697283004944 G4 box; other site 697283004945 G5 box; other site 697283004946 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 697283004947 dimer interface [polypeptide binding]; other site 697283004948 FMN binding site [chemical binding]; other site 697283004949 NADPH bind site [chemical binding]; other site 697283004950 primosomal protein DnaI; Reviewed; Region: PRK08939 697283004951 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 697283004952 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697283004953 Walker A motif; other site 697283004954 ATP binding site [chemical binding]; other site 697283004955 Walker B motif; other site 697283004956 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 697283004957 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 697283004958 ATP cone domain; Region: ATP-cone; pfam03477 697283004959 Predicted transcriptional regulators [Transcription]; Region: COG1725 697283004960 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 697283004961 DNA-binding site [nucleotide binding]; DNA binding site 697283004962 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 697283004963 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 697283004964 Walker A/P-loop; other site 697283004965 ATP binding site [chemical binding]; other site 697283004966 Q-loop/lid; other site 697283004967 ABC transporter signature motif; other site 697283004968 Walker B; other site 697283004969 D-loop; other site 697283004970 H-loop/switch region; other site 697283004971 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 697283004972 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 697283004973 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697283004974 Walker A/P-loop; other site 697283004975 ATP binding site [chemical binding]; other site 697283004976 Q-loop/lid; other site 697283004977 ABC transporter signature motif; other site 697283004978 Walker B; other site 697283004979 D-loop; other site 697283004980 H-loop/switch region; other site 697283004981 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 697283004982 Uncharacterized conserved protein [Function unknown]; Region: COG0398 697283004983 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 697283004984 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 697283004985 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 697283004986 nucleotide binding site [chemical binding]; other site 697283004987 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 697283004988 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 697283004989 active site turn [active] 697283004990 phosphorylation site [posttranslational modification] 697283004991 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 697283004992 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 697283004993 HPr interaction site; other site 697283004994 glycerol kinase (GK) interaction site [polypeptide binding]; other site 697283004995 active site 697283004996 phosphorylation site [posttranslational modification] 697283004997 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 697283004998 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 697283004999 substrate binding [chemical binding]; other site 697283005000 active site 697283005001 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 697283005002 Transcriptional regulators [Transcription]; Region: PurR; COG1609 697283005003 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 697283005004 DNA binding site [nucleotide binding] 697283005005 domain linker motif; other site 697283005006 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 697283005007 dimerization interface [polypeptide binding]; other site 697283005008 ligand binding site [chemical binding]; other site 697283005009 sodium binding site [ion binding]; other site 697283005010 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 697283005011 homodimer interface [polypeptide binding]; other site 697283005012 catalytic residues [active] 697283005013 NAD binding site [chemical binding]; other site 697283005014 substrate binding pocket [chemical binding]; other site 697283005015 flexible flap; other site 697283005016 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 697283005017 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 697283005018 dimer interface [polypeptide binding]; other site 697283005019 active site 697283005020 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 697283005021 Uncharacterized conserved protein [Function unknown]; Region: COG3610 697283005022 Uncharacterized conserved protein [Function unknown]; Region: COG2966 697283005023 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 697283005024 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 697283005025 Catalytic domain of Protein Kinases; Region: PKc; cd00180 697283005026 active site 697283005027 ATP binding site [chemical binding]; other site 697283005028 substrate binding site [chemical binding]; other site 697283005029 activation loop (A-loop); other site 697283005030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 697283005031 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 697283005032 PASTA domain; Region: PASTA; smart00740 697283005033 PASTA domain; Region: PASTA; smart00740 697283005034 PASTA domain; Region: PASTA; smart00740 697283005035 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 697283005036 active site 697283005037 16S rRNA methyltransferase B; Provisional; Region: PRK14902 697283005038 NusB family; Region: NusB; pfam01029 697283005039 putative RNA binding site [nucleotide binding]; other site 697283005040 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697283005041 S-adenosylmethionine binding site [chemical binding]; other site 697283005042 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 697283005043 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 697283005044 putative active site [active] 697283005045 substrate binding site [chemical binding]; other site 697283005046 putative cosubstrate binding site; other site 697283005047 catalytic site [active] 697283005048 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 697283005049 substrate binding site [chemical binding]; other site 697283005050 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 697283005051 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 697283005052 ATP binding site [chemical binding]; other site 697283005053 putative Mg++ binding site [ion binding]; other site 697283005054 helicase superfamily c-terminal domain; Region: HELICc; smart00490 697283005055 ATP-binding site [chemical binding]; other site 697283005056 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 697283005057 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 697283005058 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 697283005059 catalytic site [active] 697283005060 G-X2-G-X-G-K; other site 697283005061 hypothetical protein; Provisional; Region: PRK00106 697283005062 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 697283005063 Zn2+ binding site [ion binding]; other site 697283005064 Mg2+ binding site [ion binding]; other site 697283005065 hypothetical protein; Provisional; Region: PRK13670 697283005066 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 697283005067 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697283005068 S-adenosylmethionine binding site [chemical binding]; other site 697283005069 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 697283005070 Isochorismatase family; Region: Isochorismatase; pfam00857 697283005071 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 697283005072 catalytic triad [active] 697283005073 conserved cis-peptide bond; other site 697283005074 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 697283005075 Zn2+ binding site [ion binding]; other site 697283005076 Mg2+ binding site [ion binding]; other site 697283005077 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 697283005078 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 697283005079 active site 697283005080 (T/H)XGH motif; other site 697283005081 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 697283005082 GTPase YqeH; Provisional; Region: PRK13796 697283005083 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 697283005084 GTP/Mg2+ binding site [chemical binding]; other site 697283005085 G4 box; other site 697283005086 G5 box; other site 697283005087 G1 box; other site 697283005088 Switch I region; other site 697283005089 G2 box; other site 697283005090 G3 box; other site 697283005091 Switch II region; other site 697283005092 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 697283005093 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697283005094 active site 697283005095 motif I; other site 697283005096 motif II; other site 697283005097 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 697283005098 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 697283005099 Cl binding site [ion binding]; other site 697283005100 oligomer interface [polypeptide binding]; other site 697283005101 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 697283005102 Mechanosensitive ion channel; Region: MS_channel; pfam00924 697283005103 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 697283005104 serine/threonine transporter SstT; Provisional; Region: PRK14695 697283005105 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 697283005106 Predicted membrane protein [Function unknown]; Region: COG4129 697283005107 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 697283005108 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 697283005109 MarR family; Region: MarR; pfam01047 697283005110 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 697283005111 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 697283005112 catalytic residues [active] 697283005113 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 697283005114 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 697283005115 amphipathic channel; other site 697283005116 Asn-Pro-Ala signature motifs; other site 697283005117 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 697283005118 ABC-2 type transporter; Region: ABC2_membrane; cl17235 697283005119 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 697283005120 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697283005121 Walker A/P-loop; other site 697283005122 ATP binding site [chemical binding]; other site 697283005123 Q-loop/lid; other site 697283005124 ABC transporter signature motif; other site 697283005125 Walker B; other site 697283005126 D-loop; other site 697283005127 H-loop/switch region; other site 697283005128 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 697283005129 dimerization interface [polypeptide binding]; other site 697283005130 putative DNA binding site [nucleotide binding]; other site 697283005131 putative Zn2+ binding site [ion binding]; other site 697283005132 oligoendopeptidase F; Region: pepF; TIGR00181 697283005133 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 697283005134 Zn binding site [ion binding]; other site 697283005135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 697283005136 RNA methyltransferase, RsmE family; Region: TIGR00046 697283005137 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 697283005138 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697283005139 S-adenosylmethionine binding site [chemical binding]; other site 697283005140 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 697283005141 nudix motif; other site 697283005142 Peptidase family M50; Region: Peptidase_M50; pfam02163 697283005143 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 697283005144 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 697283005145 YcfA-like protein; Region: YcfA; pfam07927 697283005146 recombination factor protein RarA; Reviewed; Region: PRK13342 697283005147 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697283005148 Walker A motif; other site 697283005149 ATP binding site [chemical binding]; other site 697283005150 Walker B motif; other site 697283005151 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 697283005152 arginine finger; other site 697283005153 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 697283005154 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 697283005155 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 697283005156 substrate binding [chemical binding]; other site 697283005157 active site 697283005158 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 697283005159 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 697283005160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283005161 dimer interface [polypeptide binding]; other site 697283005162 conserved gate region; other site 697283005163 putative PBP binding loops; other site 697283005164 ABC-ATPase subunit interface; other site 697283005165 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 697283005166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283005167 dimer interface [polypeptide binding]; other site 697283005168 conserved gate region; other site 697283005169 putative PBP binding loops; other site 697283005170 ABC-ATPase subunit interface; other site 697283005171 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 697283005172 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 697283005173 Transcriptional regulators [Transcription]; Region: PurR; COG1609 697283005174 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 697283005175 DNA binding site [nucleotide binding] 697283005176 domain linker motif; other site 697283005177 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 697283005178 dimerization interface [polypeptide binding]; other site 697283005179 ligand binding site [chemical binding]; other site 697283005180 sodium binding site [ion binding]; other site 697283005181 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 697283005182 Mga helix-turn-helix domain; Region: Mga; pfam05043 697283005183 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 697283005184 Predicted membrane protein [Function unknown]; Region: COG2261 697283005185 Small integral membrane protein [Function unknown]; Region: COG5547 697283005186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 697283005187 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 697283005188 Integrase core domain; Region: rve; pfam00665 697283005189 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 697283005190 Uncharacterized conserved protein [Function unknown]; Region: COG1262 697283005191 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 697283005192 arylsulfatase; Provisional; Region: PRK13759 697283005193 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 697283005194 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 697283005195 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 697283005196 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 697283005197 active site 697283005198 methionine cluster; other site 697283005199 phosphorylation site [posttranslational modification] 697283005200 metal binding site [ion binding]; metal-binding site 697283005201 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 697283005202 active site 697283005203 P-loop; other site 697283005204 phosphorylation site [posttranslational modification] 697283005205 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 697283005206 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 697283005207 active site 697283005208 catalytic residues [active] 697283005209 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270 697283005210 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 697283005211 MarR family; Region: MarR_2; pfam12802 697283005212 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 697283005213 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 697283005214 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 697283005215 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697283005216 Coenzyme A binding pocket [chemical binding]; other site 697283005217 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 697283005218 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 697283005219 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 697283005220 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 697283005221 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697283005222 non-specific DNA binding site [nucleotide binding]; other site 697283005223 salt bridge; other site 697283005224 sequence-specific DNA binding site [nucleotide binding]; other site 697283005225 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 697283005226 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 697283005227 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 697283005228 substrate binding site [chemical binding]; other site 697283005229 active site 697283005230 catalytic residues [active] 697283005231 heterodimer interface [polypeptide binding]; other site 697283005232 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 697283005233 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 697283005234 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697283005235 catalytic residue [active] 697283005236 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 697283005237 active site 697283005238 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 697283005239 active site 697283005240 ribulose/triose binding site [chemical binding]; other site 697283005241 phosphate binding site [ion binding]; other site 697283005242 substrate (anthranilate) binding pocket [chemical binding]; other site 697283005243 product (indole) binding pocket [chemical binding]; other site 697283005244 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 697283005245 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 697283005246 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 697283005247 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 697283005248 Glutamine amidotransferase class-I; Region: GATase; pfam00117 697283005249 glutamine binding [chemical binding]; other site 697283005250 catalytic triad [active] 697283005251 anthranilate synthase component I; Provisional; Region: PRK13570 697283005252 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 697283005253 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 697283005254 T-box leader 697283005255 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 697283005256 T-box leader 697283005257 Transcriptional regulators [Transcription]; Region: PurR; COG1609 697283005258 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 697283005259 DNA binding site [nucleotide binding] 697283005260 domain linker motif; other site 697283005261 Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276 697283005262 putative dimerization interface [polypeptide binding]; other site 697283005263 putative ligand binding site [chemical binding]; other site 697283005264 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 697283005265 MgtC family; Region: MgtC; pfam02308 697283005266 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 697283005267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283005268 dimer interface [polypeptide binding]; other site 697283005269 conserved gate region; other site 697283005270 putative PBP binding loops; other site 697283005271 ABC-ATPase subunit interface; other site 697283005272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283005273 putative PBP binding loops; other site 697283005274 dimer interface [polypeptide binding]; other site 697283005275 ABC-ATPase subunit interface; other site 697283005276 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 697283005277 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697283005278 Walker A/P-loop; other site 697283005279 ATP binding site [chemical binding]; other site 697283005280 Q-loop/lid; other site 697283005281 ABC transporter signature motif; other site 697283005282 Walker B; other site 697283005283 D-loop; other site 697283005284 H-loop/switch region; other site 697283005285 TOBE domain; Region: TOBE; pfam03459 697283005286 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 697283005287 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 697283005288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255 697283005289 Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975 697283005290 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 697283005291 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 697283005292 Pectate lyase; Region: Pec_lyase_C; cl01593 697283005293 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 697283005294 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 697283005295 inhibitor-cofactor binding pocket; inhibition site 697283005296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697283005297 catalytic residue [active] 697283005298 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 697283005299 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 697283005300 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 697283005301 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 697283005302 Walker A/P-loop; other site 697283005303 ATP binding site [chemical binding]; other site 697283005304 Q-loop/lid; other site 697283005305 ABC transporter signature motif; other site 697283005306 Walker B; other site 697283005307 D-loop; other site 697283005308 H-loop/switch region; other site 697283005309 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 697283005310 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 697283005311 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697283005312 Walker A/P-loop; other site 697283005313 ATP binding site [chemical binding]; other site 697283005314 Q-loop/lid; other site 697283005315 ABC transporter signature motif; other site 697283005316 Walker B; other site 697283005317 D-loop; other site 697283005318 H-loop/switch region; other site 697283005319 Predicted membrane protein [Function unknown]; Region: COG2323 697283005320 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 697283005321 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 697283005322 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 697283005323 active site 697283005324 putative catalytic site [active] 697283005325 DNA binding site [nucleotide binding] 697283005326 putative phosphate binding site [ion binding]; other site 697283005327 metal binding site A [ion binding]; metal-binding site 697283005328 AP binding site [nucleotide binding]; other site 697283005329 metal binding site B [ion binding]; metal-binding site 697283005330 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 697283005331 active site 697283005332 xanthine permease; Region: pbuX; TIGR03173 697283005333 Sulfate transporter family; Region: Sulfate_transp; pfam00916 697283005334 DpnII restriction endonuclease; Region: DpnII; pfam04556 697283005335 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 697283005336 DNA methylase; Region: N6_N4_Mtase; pfam01555 697283005337 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697283005338 S-adenosylmethionine binding site [chemical binding]; other site 697283005339 DNA adenine methylase (dam); Region: dam; TIGR00571 697283005340 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 697283005341 CoenzymeA binding site [chemical binding]; other site 697283005342 subunit interaction site [polypeptide binding]; other site 697283005343 PHB binding site; other site 697283005344 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 697283005345 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 697283005346 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 697283005347 galactokinase; Provisional; Region: PRK05322 697283005348 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 697283005349 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 697283005350 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 697283005351 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 697283005352 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 697283005353 DNA binding site [nucleotide binding] 697283005354 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 697283005355 putative dimerization interface [polypeptide binding]; other site 697283005356 putative ligand binding site [chemical binding]; other site 697283005357 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 697283005358 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 697283005359 catalytic Zn binding site [ion binding]; other site 697283005360 NAD(P) binding site [chemical binding]; other site 697283005361 structural Zn binding site [ion binding]; other site 697283005362 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 697283005363 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 697283005364 DNA binding residues [nucleotide binding] 697283005365 putative dimer interface [polypeptide binding]; other site 697283005366 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 697283005367 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 697283005368 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 697283005369 nicotinamide mononucleotide transporter PnuC; Region: NMN_trans_PnuC; TIGR01528 697283005370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283005371 dimer interface [polypeptide binding]; other site 697283005372 conserved gate region; other site 697283005373 ABC-ATPase subunit interface; other site 697283005374 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 697283005375 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 697283005376 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 697283005377 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697283005378 Walker A/P-loop; other site 697283005379 ATP binding site [chemical binding]; other site 697283005380 Q-loop/lid; other site 697283005381 ABC transporter signature motif; other site 697283005382 Walker B; other site 697283005383 D-loop; other site 697283005384 H-loop/switch region; other site 697283005385 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 697283005386 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 697283005387 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 697283005388 Enterocin A Immunity; Region: EntA_Immun; pfam08951 697283005389 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 697283005390 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 697283005391 oligomer interface [polypeptide binding]; other site 697283005392 active site 697283005393 metal binding site [ion binding]; metal-binding site 697283005394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697283005395 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 697283005396 NAD(P) binding site [chemical binding]; other site 697283005397 active site 697283005398 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 697283005399 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 697283005400 ABC-ATPase subunit interface; other site 697283005401 dimer interface [polypeptide binding]; other site 697283005402 putative PBP binding regions; other site 697283005403 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 697283005404 ABC-ATPase subunit interface; other site 697283005405 dimer interface [polypeptide binding]; other site 697283005406 putative PBP binding regions; other site 697283005407 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 697283005408 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 697283005409 Walker A/P-loop; other site 697283005410 ATP binding site [chemical binding]; other site 697283005411 Q-loop/lid; other site 697283005412 ABC transporter signature motif; other site 697283005413 Walker B; other site 697283005414 D-loop; other site 697283005415 H-loop/switch region; other site 697283005416 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 697283005417 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 697283005418 putative ligand binding residues [chemical binding]; other site 697283005419 hypothetical protein; Validated; Region: PRK00041 697283005420 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 697283005421 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 697283005422 RNA binding surface [nucleotide binding]; other site 697283005423 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 697283005424 active site 697283005425 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 697283005426 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 697283005427 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 697283005428 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 697283005429 DNA binding site [nucleotide binding] 697283005430 Int/Topo IB signature motif; other site 697283005431 active site 697283005432 catalytic residues [active] 697283005433 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 697283005434 FOG: CBS domain [General function prediction only]; Region: COG0517 697283005435 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 697283005436 active site 697283005437 metal binding site [ion binding]; metal-binding site 697283005438 homotetramer interface [polypeptide binding]; other site 697283005439 putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491 697283005440 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 697283005441 active site 697283005442 dimerization interface [polypeptide binding]; other site 697283005443 glutamate racemase; Provisional; Region: PRK00865 697283005444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 697283005445 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 697283005446 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 697283005447 Ca binding site [ion binding]; other site 697283005448 active site 697283005449 catalytic site [active] 697283005450 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 697283005451 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 697283005452 active site turn [active] 697283005453 phosphorylation site [posttranslational modification] 697283005454 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 697283005455 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 697283005456 HPr interaction site; other site 697283005457 glycerol kinase (GK) interaction site [polypeptide binding]; other site 697283005458 active site 697283005459 phosphorylation site [posttranslational modification] 697283005460 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 697283005461 DNA-binding site [nucleotide binding]; DNA binding site 697283005462 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 697283005463 UTRA domain; Region: UTRA; pfam07702 697283005464 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 697283005465 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697283005466 Walker A/P-loop; other site 697283005467 ATP binding site [chemical binding]; other site 697283005468 Q-loop/lid; other site 697283005469 ABC transporter signature motif; other site 697283005470 Walker B; other site 697283005471 D-loop; other site 697283005472 H-loop/switch region; other site 697283005473 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 697283005474 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 697283005475 Walker A/P-loop; other site 697283005476 ATP binding site [chemical binding]; other site 697283005477 Q-loop/lid; other site 697283005478 ABC transporter signature motif; other site 697283005479 Walker B; other site 697283005480 D-loop; other site 697283005481 H-loop/switch region; other site 697283005482 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 697283005483 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 697283005484 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 697283005485 Walker A/P-loop; other site 697283005486 ATP binding site [chemical binding]; other site 697283005487 Q-loop/lid; other site 697283005488 ABC transporter signature motif; other site 697283005489 Walker B; other site 697283005490 D-loop; other site 697283005491 H-loop/switch region; other site 697283005492 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 697283005493 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 697283005494 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 697283005495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283005496 dimer interface [polypeptide binding]; other site 697283005497 conserved gate region; other site 697283005498 putative PBP binding loops; other site 697283005499 ABC-ATPase subunit interface; other site 697283005500 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 697283005501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283005502 dimer interface [polypeptide binding]; other site 697283005503 conserved gate region; other site 697283005504 putative PBP binding loops; other site 697283005505 ABC-ATPase subunit interface; other site 697283005506 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 697283005507 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 697283005508 peptide binding site [polypeptide binding]; other site 697283005509 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 697283005510 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 697283005511 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 697283005512 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 697283005513 active site 697283005514 homodimer interface [polypeptide binding]; other site 697283005515 catalytic site [active] 697283005516 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 697283005517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283005518 dimer interface [polypeptide binding]; other site 697283005519 conserved gate region; other site 697283005520 putative PBP binding loops; other site 697283005521 ABC-ATPase subunit interface; other site 697283005522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283005523 dimer interface [polypeptide binding]; other site 697283005524 conserved gate region; other site 697283005525 putative PBP binding loops; other site 697283005526 ABC-ATPase subunit interface; other site 697283005527 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 697283005528 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 697283005529 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 697283005530 Melibiase; Region: Melibiase; pfam02065 697283005531 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 697283005532 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 697283005533 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 697283005534 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 697283005535 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 697283005536 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 697283005537 DNA-binding site [nucleotide binding]; DNA binding site 697283005538 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 697283005539 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 697283005540 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 697283005541 Transposase; Region: DDE_Tnp_ISL3; pfam01610 697283005542 TRAM domain; Region: TRAM; pfam01938 697283005543 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 697283005544 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697283005545 S-adenosylmethionine binding site [chemical binding]; other site 697283005546 recombination regulator RecX; Provisional; Region: recX; PRK14135 697283005547 hypothetical protein; Provisional; Region: PRK13662 697283005548 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 697283005549 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 697283005550 ring oligomerisation interface [polypeptide binding]; other site 697283005551 ATP/Mg binding site [chemical binding]; other site 697283005552 stacking interactions; other site 697283005553 hinge regions; other site 697283005554 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 697283005555 oligomerisation interface [polypeptide binding]; other site 697283005556 mobile loop; other site 697283005557 roof hairpin; other site 697283005558 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 697283005559 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 697283005560 dimer interface [polypeptide binding]; other site 697283005561 ssDNA binding site [nucleotide binding]; other site 697283005562 tetramer (dimer of dimers) interface [polypeptide binding]; other site 697283005563 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 697283005564 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 697283005565 putative NAD(P) binding site [chemical binding]; other site 697283005566 homodimer interface [polypeptide binding]; other site 697283005567 homotetramer interface [polypeptide binding]; other site 697283005568 active site 697283005569 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 697283005570 putative tRNA-binding site [nucleotide binding]; other site 697283005571 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 697283005572 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 697283005573 catalytic residues [active] 697283005574 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 697283005575 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 697283005576 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 697283005577 LytTr DNA-binding domain; Region: LytTR; pfam04397 697283005578 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 697283005579 active site 697283005580 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 697283005581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4898 697283005582 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697283005583 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 697283005584 Walker A/P-loop; other site 697283005585 ATP binding site [chemical binding]; other site 697283005586 Q-loop/lid; other site 697283005587 ABC transporter signature motif; other site 697283005588 Walker B; other site 697283005589 D-loop; other site 697283005590 H-loop/switch region; other site 697283005591 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 697283005592 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 697283005593 hypothetical protein; Provisional; Region: PRK12378 697283005594 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 697283005595 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 697283005596 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 697283005597 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 697283005598 Domain of unknown function (DUF955); Region: DUF955; cl01076 697283005599 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 697283005600 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697283005601 non-specific DNA binding site [nucleotide binding]; other site 697283005602 salt bridge; other site 697283005603 sequence-specific DNA binding site [nucleotide binding]; other site 697283005604 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 697283005605 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 697283005606 amidase catalytic site [active] 697283005607 Zn binding residues [ion binding]; other site 697283005608 substrate binding site [chemical binding]; other site 697283005609 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 697283005610 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 697283005611 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 697283005612 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 697283005613 recombinase A; Provisional; Region: recA; PRK09354 697283005614 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 697283005615 hexamer interface [polypeptide binding]; other site 697283005616 Walker A motif; other site 697283005617 ATP binding site [chemical binding]; other site 697283005618 Walker B motif; other site 697283005619 competence damage-inducible protein A; Provisional; Region: PRK00549 697283005620 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 697283005621 putative MPT binding site; other site 697283005622 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 697283005623 Transcriptional regulator [Transcription]; Region: LytR; COG1316 697283005624 putative acetyltransferase YhhY; Provisional; Region: PRK10140 697283005625 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697283005626 Coenzyme A binding pocket [chemical binding]; other site 697283005627 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 697283005628 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 697283005629 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697283005630 non-specific DNA binding site [nucleotide binding]; other site 697283005631 salt bridge; other site 697283005632 sequence-specific DNA binding site [nucleotide binding]; other site 697283005633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 697283005634 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 697283005635 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 697283005636 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 697283005637 Walker A/P-loop; other site 697283005638 ATP binding site [chemical binding]; other site 697283005639 Q-loop/lid; other site 697283005640 ABC transporter signature motif; other site 697283005641 Walker B; other site 697283005642 D-loop; other site 697283005643 H-loop/switch region; other site 697283005644 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 697283005645 active site 697283005646 multimer interface [polypeptide binding]; other site 697283005647 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 697283005648 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 697283005649 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 697283005650 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 697283005651 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 697283005652 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 697283005653 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 697283005654 G-loop; other site 697283005655 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 697283005656 DNA binding site [nucleotide binding] 697283005657 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 697283005658 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 697283005659 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 697283005660 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 697283005661 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 697283005662 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 697283005663 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 697283005664 RPB1 interaction site [polypeptide binding]; other site 697283005665 RPB10 interaction site [polypeptide binding]; other site 697283005666 RPB11 interaction site [polypeptide binding]; other site 697283005667 RPB3 interaction site [polypeptide binding]; other site 697283005668 RPB12 interaction site [polypeptide binding]; other site 697283005669 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 697283005670 Domain of unknown function DUF21; Region: DUF21; pfam01595 697283005671 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 697283005672 Transporter associated domain; Region: CorC_HlyC; smart01091 697283005673 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 697283005674 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223 697283005675 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 697283005676 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 697283005677 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 697283005678 hinge; other site 697283005679 active site 697283005680 Protein of unknown function (DUF1146); Region: DUF1146; pfam06612 697283005681 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 697283005682 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 697283005683 protein binding site [polypeptide binding]; other site 697283005684 Phosphopantetheine adenylyltransferase [Coenzyme metabolism]; Region: CoaD; COG0669 697283005685 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 697283005686 active site 697283005687 (T/H)XGH motif; other site 697283005688 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 697283005689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697283005690 S-adenosylmethionine binding site [chemical binding]; other site 697283005691 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 697283005692 dimer interface [polypeptide binding]; other site 697283005693 active site 697283005694 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 697283005695 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 697283005696 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 697283005697 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 697283005698 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 697283005699 acylphosphatase; Provisional; Region: PRK14434 697283005700 OxaA-like protein precursor; Provisional; Region: PRK02463 697283005701 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 697283005702 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 697283005703 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697283005704 FeS/SAM binding site; other site 697283005705 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 697283005706 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 697283005707 active site 697283005708 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 697283005709 substrate binding site [chemical binding]; other site 697283005710 catalytic residues [active] 697283005711 dimer interface [polypeptide binding]; other site 697283005712 pur operon repressor; Provisional; Region: PRK09213 697283005713 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 697283005714 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 697283005715 active site 697283005716 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 697283005717 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 697283005718 generic binding surface II; other site 697283005719 generic binding surface I; other site 697283005720 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 697283005721 Zn2+ binding site [ion binding]; other site 697283005722 Mg2+ binding site [ion binding]; other site 697283005723 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 697283005724 RmuC family; Region: RmuC; pfam02646 697283005725 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 697283005726 Thiamine pyrophosphokinase; Region: TPK; cd07995 697283005727 active site 697283005728 dimerization interface [polypeptide binding]; other site 697283005729 thiamine binding site [chemical binding]; other site 697283005730 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 697283005731 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 697283005732 substrate binding site [chemical binding]; other site 697283005733 hexamer interface [polypeptide binding]; other site 697283005734 metal binding site [ion binding]; metal-binding site 697283005735 GTPase RsgA; Reviewed; Region: PRK00098 697283005736 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 697283005737 RNA binding site [nucleotide binding]; other site 697283005738 homodimer interface [polypeptide binding]; other site 697283005739 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 697283005740 GTPase/Zn-binding domain interface [polypeptide binding]; other site 697283005741 GTP/Mg2+ binding site [chemical binding]; other site 697283005742 G4 box; other site 697283005743 G5 box; other site 697283005744 G1 box; other site 697283005745 Switch I region; other site 697283005746 G2 box; other site 697283005747 G3 box; other site 697283005748 Switch II region; other site 697283005749 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 697283005750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697283005751 S-adenosylmethionine binding site [chemical binding]; other site 697283005752 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 697283005753 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 697283005754 Walker A/P-loop; other site 697283005755 ATP binding site [chemical binding]; other site 697283005756 Q-loop/lid; other site 697283005757 ABC transporter signature motif; other site 697283005758 Walker B; other site 697283005759 D-loop; other site 697283005760 H-loop/switch region; other site 697283005761 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 697283005762 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697283005763 non-specific DNA binding site [nucleotide binding]; other site 697283005764 salt bridge; other site 697283005765 sequence-specific DNA binding site [nucleotide binding]; other site 697283005766 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 697283005767 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 697283005768 putative active site [active] 697283005769 putative metal binding site [ion binding]; other site 697283005770 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 697283005771 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 697283005772 active site 697283005773 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 697283005774 aminotransferase AlaT; Validated; Region: PRK09265 697283005775 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 697283005776 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697283005777 homodimer interface [polypeptide binding]; other site 697283005778 catalytic residue [active] 697283005779 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 697283005780 Ligand Binding Site [chemical binding]; other site 697283005781 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697283005782 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 697283005783 active site 697283005784 motif I; other site 697283005785 motif II; other site 697283005786 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697283005787 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 697283005788 putative nucleotide binding site [chemical binding]; other site 697283005789 putative metal binding site [ion binding]; other site 697283005790 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 697283005791 active site 697283005792 homotetramer interface [polypeptide binding]; other site 697283005793 homodimer interface [polypeptide binding]; other site 697283005794 catabolite control protein A; Region: ccpA; TIGR01481 697283005795 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 697283005796 DNA binding site [nucleotide binding] 697283005797 domain linker motif; other site 697283005798 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 697283005799 dimerization interface [polypeptide binding]; other site 697283005800 effector binding site; other site 697283005801 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 697283005802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697283005803 active site 697283005804 phosphorylation site [posttranslational modification] 697283005805 intermolecular recognition site; other site 697283005806 dimerization interface [polypeptide binding]; other site 697283005807 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 697283005808 DNA binding residues [nucleotide binding] 697283005809 dimerization interface [polypeptide binding]; other site 697283005810 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 697283005811 Histidine kinase; Region: HisKA_3; pfam07730 697283005812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697283005813 ATP binding site [chemical binding]; other site 697283005814 Mg2+ binding site [ion binding]; other site 697283005815 G-X-G motif; other site 697283005816 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 697283005817 ABC-2 type transporter; Region: ABC2_membrane; cl17235 697283005818 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 697283005819 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 697283005820 Walker A/P-loop; other site 697283005821 ATP binding site [chemical binding]; other site 697283005822 Q-loop/lid; other site 697283005823 ABC transporter signature motif; other site 697283005824 Walker B; other site 697283005825 D-loop; other site 697283005826 H-loop/switch region; other site 697283005827 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 697283005828 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 697283005829 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 697283005830 putative homodimer interface [polypeptide binding]; other site 697283005831 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 697283005832 heterodimer interface [polypeptide binding]; other site 697283005833 homodimer interface [polypeptide binding]; other site 697283005834 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 697283005835 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 697283005836 Transglycosylase; Region: Transgly; pfam00912 697283005837 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 697283005838 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 697283005839 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 697283005840 active site 697283005841 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 697283005842 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 697283005843 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 697283005844 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 697283005845 FtsX-like permease family; Region: FtsX; pfam02687 697283005846 DDE superfamily endonuclease; Region: DDE_3; pfam13358 697283005847 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 697283005848 Helix-turn-helix domain; Region: HTH_28; pfam13518 697283005849 Winged helix-turn helix; Region: HTH_29; pfam13551 697283005850 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06559 697283005851 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 697283005852 dimerization interface [polypeptide binding]; other site 697283005853 active site 697283005854 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 697283005855 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 697283005856 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 697283005857 Walker A/P-loop; other site 697283005858 ATP binding site [chemical binding]; other site 697283005859 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 697283005860 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 697283005861 DNA-binding site [nucleotide binding]; DNA binding site 697283005862 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 697283005863 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 697283005864 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 697283005865 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 697283005866 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 697283005867 active site 697283005868 P-loop; other site 697283005869 phosphorylation site [posttranslational modification] 697283005870 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 697283005871 methionine cluster; other site 697283005872 active site 697283005873 phosphorylation site [posttranslational modification] 697283005874 metal binding site [ion binding]; metal-binding site 697283005875 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 697283005876 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 697283005877 putative catalytic cysteine [active] 697283005878 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 697283005879 putative active site [active] 697283005880 metal binding site [ion binding]; metal-binding site 697283005881 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 697283005882 MORN repeat; Region: MORN; cl14787 697283005883 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 697283005884 Low molecular weight phosphatase family; Region: LMWPc; cd00115 697283005885 preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531 697283005886 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 697283005887 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 697283005888 TPP-binding site [chemical binding]; other site 697283005889 dimer interface [polypeptide binding]; other site 697283005890 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 697283005891 PYR/PP interface [polypeptide binding]; other site 697283005892 dimer interface [polypeptide binding]; other site 697283005893 TPP binding site [chemical binding]; other site 697283005894 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 697283005895 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 697283005896 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 697283005897 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 697283005898 PRD domain; Region: PRD; pfam00874 697283005899 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 697283005900 active site 697283005901 P-loop; other site 697283005902 phosphorylation site [posttranslational modification] 697283005903 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 697283005904 L-ribulose-5-phosphate 4-epimerase; Provisional; Region: araD; PRK13145 697283005905 intersubunit interface [polypeptide binding]; other site 697283005906 active site 697283005907 Zn2+ binding site [ion binding]; other site 697283005908 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 697283005909 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 697283005910 AP (apurinic/apyrimidinic) site pocket; other site 697283005911 DNA interaction; other site 697283005912 Metal-binding active site; metal-binding site 697283005913 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 697283005914 active site 697283005915 dimer interface [polypeptide binding]; other site 697283005916 magnesium binding site [ion binding]; other site 697283005917 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 697283005918 active site 697283005919 phosphorylation site [posttranslational modification] 697283005920 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 697283005921 active site 697283005922 P-loop; other site 697283005923 phosphorylation site [posttranslational modification] 697283005924 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 697283005925 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 697283005926 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 697283005927 G-X-X-G motif; other site 697283005928 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 697283005929 RxxxH motif; other site 697283005930 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 697283005931 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 697283005932 ribonuclease P; Reviewed; Region: rnpA; PRK00499 697283005933 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 697283005934 propionate/acetate kinase; Provisional; Region: PRK12379 697283005935 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 697283005936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697283005937 S-adenosylmethionine binding site [chemical binding]; other site 697283005938 Methyltransferase domain; Region: Methyltransf_12; pfam08242 697283005939 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 697283005940 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 697283005941 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 697283005942 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 697283005943 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 697283005944 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 697283005945 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 697283005946 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 697283005947 Walker A motif; other site 697283005948 ATP binding site [chemical binding]; other site 697283005949 Walker B motif; other site 697283005950 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 697283005951 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 697283005952 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 697283005953 catalytic Zn binding site [ion binding]; other site 697283005954 structural Zn binding site [ion binding]; other site 697283005955 NAD(P) binding site [chemical binding]; other site 697283005956 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 697283005957 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 697283005958 active site 697283005959 dimer interface [polypeptide binding]; other site 697283005960 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 697283005961 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 697283005962 catalytic triad [active] 697283005963 catalytic triad [active] 697283005964 oxyanion hole [active] 697283005965 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 697283005966 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 697283005967 Predicted integral membrane protein [Function unknown]; Region: COG5523 697283005968 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 697283005969 putative substrate binding pocket [chemical binding]; other site 697283005970 AC domain interface; other site 697283005971 catalytic triad [active] 697283005972 AB domain interface; other site 697283005973 interchain disulfide; other site 697283005974 Predicted membrane protein [Function unknown]; Region: COG3759 697283005975 Transcriptional regulators [Transcription]; Region: MarR; COG1846 697283005976 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 697283005977 putative DNA binding site [nucleotide binding]; other site 697283005978 putative Zn2+ binding site [ion binding]; other site 697283005979 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 697283005980 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 697283005981 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697283005982 motif II; other site 697283005983 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 697283005984 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 697283005985 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 697283005986 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 697283005987 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697283005988 catalytic residue [active] 697283005989 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 697283005990 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 697283005991 active site 697283005992 catalytic motif [active] 697283005993 Zn binding site [ion binding]; other site 697283005994 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 697283005995 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 697283005996 active site 697283005997 HIGH motif; other site 697283005998 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 697283005999 active site 697283006000 KMSKS motif; other site 697283006001 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 697283006002 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 697283006003 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 697283006004 active site 697283006005 dimer interface [polypeptide binding]; other site 697283006006 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 697283006007 dimer interface [polypeptide binding]; other site 697283006008 active site 697283006009 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 697283006010 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 697283006011 catalytic triad [active] 697283006012 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 697283006013 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 697283006014 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697283006015 Walker A/P-loop; other site 697283006016 ATP binding site [chemical binding]; other site 697283006017 Q-loop/lid; other site 697283006018 ABC transporter signature motif; other site 697283006019 Walker B; other site 697283006020 D-loop; other site 697283006021 H-loop/switch region; other site 697283006022 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 697283006023 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 697283006024 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 697283006025 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 697283006026 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697283006027 Walker A/P-loop; other site 697283006028 ATP binding site [chemical binding]; other site 697283006029 Q-loop/lid; other site 697283006030 ABC transporter signature motif; other site 697283006031 Walker B; other site 697283006032 D-loop; other site 697283006033 H-loop/switch region; other site 697283006034 DNA mismatch repair protein MutS; Region: mutS1; TIGR01070 697283006035 MutS domain I; Region: MutS_I; pfam01624 697283006036 MutS domain II; Region: MutS_II; pfam05188 697283006037 MutS domain III; Region: MutS_III; pfam05192 697283006038 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 697283006039 Walker A/P-loop; other site 697283006040 ATP binding site [chemical binding]; other site 697283006041 Q-loop/lid; other site 697283006042 ABC transporter signature motif; other site 697283006043 Walker B; other site 697283006044 D-loop; other site 697283006045 H-loop/switch region; other site 697283006046 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 697283006047 arginine repressor; Region: argR_whole; TIGR01529 697283006048 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 697283006049 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 697283006050 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 697283006051 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 697283006052 active site 697283006053 HIGH motif; other site 697283006054 KMSK motif region; other site 697283006055 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 697283006056 tRNA binding surface [nucleotide binding]; other site 697283006057 anticodon binding site; other site 697283006058 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 697283006059 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 697283006060 Uncharacterized conserved protein [Function unknown]; Region: COG3542 697283006061 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 697283006062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697283006063 active site 697283006064 phosphorylation site [posttranslational modification] 697283006065 intermolecular recognition site; other site 697283006066 dimerization interface [polypeptide binding]; other site 697283006067 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 697283006068 DNA binding site [nucleotide binding] 697283006069 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 697283006070 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 697283006071 dimer interface [polypeptide binding]; other site 697283006072 phosphorylation site [posttranslational modification] 697283006073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697283006074 ATP binding site [chemical binding]; other site 697283006075 G-X-G motif; other site 697283006076 PBP superfamily domain; Region: PBP_like_2; cl17296 697283006077 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 697283006078 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 697283006079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283006080 dimer interface [polypeptide binding]; other site 697283006081 conserved gate region; other site 697283006082 putative PBP binding loops; other site 697283006083 ABC-ATPase subunit interface; other site 697283006084 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 697283006085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283006086 dimer interface [polypeptide binding]; other site 697283006087 conserved gate region; other site 697283006088 putative PBP binding loops; other site 697283006089 ABC-ATPase subunit interface; other site 697283006090 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 697283006091 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 697283006092 Walker A/P-loop; other site 697283006093 ATP binding site [chemical binding]; other site 697283006094 Q-loop/lid; other site 697283006095 ABC transporter signature motif; other site 697283006096 Walker B; other site 697283006097 D-loop; other site 697283006098 H-loop/switch region; other site 697283006099 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 697283006100 PhoU domain; Region: PhoU; pfam01895 697283006101 PhoU domain; Region: PhoU; pfam01895 697283006102 DNA replication terminus site-binding protein (Ter protein); Region: Ter; cl11502 697283006103 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697283006104 non-specific DNA binding site [nucleotide binding]; other site 697283006105 salt bridge; other site 697283006106 sequence-specific DNA binding site [nucleotide binding]; other site 697283006107 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 697283006108 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 697283006109 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 697283006110 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 697283006111 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 697283006112 active site 697283006113 tetramer interface; other site 697283006114 Rhomboid family; Region: Rhomboid; pfam01694 697283006115 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 697283006116 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 697283006117 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 697283006118 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 697283006119 metal binding site [ion binding]; metal-binding site 697283006120 putative dimer interface [polypeptide binding]; other site 697283006121 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 697283006122 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 697283006123 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 697283006124 trimer interface [polypeptide binding]; other site 697283006125 active site 697283006126 substrate binding site [chemical binding]; other site 697283006127 CoA binding site [chemical binding]; other site 697283006128 EamA-like transporter family; Region: EamA; pfam00892 697283006129 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 697283006130 Transglycosylase; Region: Transgly; pfam00912 697283006131 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 697283006132 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 697283006133 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 697283006134 active site 697283006135 HIGH motif; other site 697283006136 dimer interface [polypeptide binding]; other site 697283006137 KMSKS motif; other site 697283006138 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 697283006139 RNA binding surface [nucleotide binding]; other site 697283006140 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 697283006141 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 697283006142 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697283006143 motif II; other site 697283006144 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 697283006145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697283006146 S-adenosylmethionine binding site [chemical binding]; other site 697283006147 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 697283006148 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 697283006149 4-alpha-glucanotransferase; Provisional; Region: PRK14508 697283006150 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 697283006151 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 697283006152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283006153 dimer interface [polypeptide binding]; other site 697283006154 conserved gate region; other site 697283006155 putative PBP binding loops; other site 697283006156 ABC-ATPase subunit interface; other site 697283006157 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 697283006158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697283006159 dimer interface [polypeptide binding]; other site 697283006160 conserved gate region; other site 697283006161 putative PBP binding loops; other site 697283006162 ABC-ATPase subunit interface; other site 697283006163 Predicted integral membrane protein [Function unknown]; Region: COG5521 697283006164 Transcriptional regulators [Transcription]; Region: PurR; COG1609 697283006165 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 697283006166 DNA binding site [nucleotide binding] 697283006167 domain linker motif; other site 697283006168 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 697283006169 putative dimerization interface [polypeptide binding]; other site 697283006170 putative ligand binding site [chemical binding]; other site 697283006171 Uncharacterized conserved protein [Function unknown]; Region: COG1284 697283006172 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 697283006173 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 697283006174 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 697283006175 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 697283006176 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 697283006177 dimer interface [polypeptide binding]; other site 697283006178 anticodon binding site; other site 697283006179 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 697283006180 homodimer interface [polypeptide binding]; other site 697283006181 motif 1; other site 697283006182 active site 697283006183 motif 2; other site 697283006184 GAD domain; Region: GAD; pfam02938 697283006185 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 697283006186 motif 3; other site 697283006187 CAAX protease self-immunity; Region: Abi; pfam02517 697283006188 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 697283006189 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697283006190 non-specific DNA binding site [nucleotide binding]; other site 697283006191 salt bridge; other site 697283006192 sequence-specific DNA binding site [nucleotide binding]; other site 697283006193 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 697283006194 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 697283006195 dimer interface [polypeptide binding]; other site 697283006196 motif 1; other site 697283006197 active site 697283006198 motif 2; other site 697283006199 motif 3; other site 697283006200 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 697283006201 anticodon binding site; other site 697283006202 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697283006203 non-specific DNA binding site [nucleotide binding]; other site 697283006204 salt bridge; other site 697283006205 sequence-specific DNA binding site [nucleotide binding]; other site 697283006206 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 697283006207 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 697283006208 6-phosphogluconate dehydratase; Region: edd; TIGR01196 697283006209 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 697283006210 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 697283006211 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 697283006212 PYR/PP interface [polypeptide binding]; other site 697283006213 dimer interface [polypeptide binding]; other site 697283006214 TPP binding site [chemical binding]; other site 697283006215 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 697283006216 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 697283006217 TPP-binding site [chemical binding]; other site 697283006218 dimer interface [polypeptide binding]; other site 697283006219 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 697283006220 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 697283006221 active site 697283006222 P-loop; other site 697283006223 phosphorylation site [posttranslational modification] 697283006224 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 697283006225 PRD domain; Region: PRD; pfam00874 697283006226 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 697283006227 active site 697283006228 P-loop; other site 697283006229 phosphorylation site [posttranslational modification] 697283006230 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 697283006231 active site 697283006232 phosphorylation site [posttranslational modification] 697283006233 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 697283006234 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 697283006235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 697283006236 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 697283006237 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 697283006238 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 697283006239 putative active site [active] 697283006240 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 697283006241 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 697283006242 nucleotide binding site [chemical binding]; other site 697283006243 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 697283006244 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 697283006245 active site 697283006246 metal binding site [ion binding]; metal-binding site 697283006247 homodimer interface [polypeptide binding]; other site 697283006248 catalytic site [active] 697283006249 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 697283006250 Uncharacterized conserved protein [Function unknown]; Region: COG3538 697283006251 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 697283006252 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 697283006253 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 697283006254 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 697283006255 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 697283006256 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 697283006257 arginine deiminase; Provisional; Region: PRK01388 697283006258 ornithine carbamoyltransferase; Validated; Region: PRK02102 697283006259 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 697283006260 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 697283006261 carbamate kinase; Reviewed; Region: PRK12686 697283006262 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 697283006263 putative substrate binding site [chemical binding]; other site 697283006264 nucleotide binding site [chemical binding]; other site 697283006265 nucleotide binding site [chemical binding]; other site 697283006266 homodimer interface [polypeptide binding]; other site 697283006267 Predicted membrane protein [Function unknown]; Region: COG1288 697283006268 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 697283006269 hypothetical protein; Provisional; Region: PRK07205 697283006270 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 697283006271 active site 697283006272 metal binding site [ion binding]; metal-binding site 697283006273 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 697283006274 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 697283006275 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 697283006276 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 697283006277 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 697283006278 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 697283006279 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 697283006280 dimer interface [polypeptide binding]; other site 697283006281 active site 697283006282 metal binding site [ion binding]; metal-binding site 697283006283 L-fucose isomerase; Provisional; Region: fucI; PRK10991 697283006284 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 697283006285 hexamer (dimer of trimers) interface [polypeptide binding]; other site 697283006286 trimer interface [polypeptide binding]; other site 697283006287 substrate binding site [chemical binding]; other site 697283006288 Mn binding site [ion binding]; other site 697283006289 Glycosyl hydrolase family 98; Region: Glyco_hydro_98M; pfam08306 697283006290 Glycosyl hydrolase family 98 C-terminal domain; Region: Glyco_hydro_98C; pfam08307 697283006291 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 697283006292 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 697283006293 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 697283006294 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 697283006295 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 697283006296 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 697283006297 active site 697283006298 phosphorylation site [posttranslational modification] 697283006299 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 697283006300 active pocket/dimerization site; other site 697283006301 active site 697283006302 phosphorylation site [posttranslational modification] 697283006303 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 697283006304 L-fuculose phosphate aldolase; Provisional; Region: PRK06833 697283006305 intersubunit interface [polypeptide binding]; other site 697283006306 active site 697283006307 Zn2+ binding site [ion binding]; other site 697283006308 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 697283006309 N- and C-terminal domain interface [polypeptide binding]; other site 697283006310 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 697283006311 active site 697283006312 putative catalytic site [active] 697283006313 metal binding site [ion binding]; metal-binding site 697283006314 ATP binding site [chemical binding]; other site 697283006315 carbohydrate binding site [chemical binding]; other site 697283006316 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 697283006317 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 697283006318 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 697283006319 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 697283006320 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 697283006321 metal binding site [ion binding]; metal-binding site 697283006322 YodA lipocalin-like domain; Region: YodA; pfam09223 697283006323 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 697283006324 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 697283006325 ABC-ATPase subunit interface; other site 697283006326 dimer interface [polypeptide binding]; other site 697283006327 putative PBP binding regions; other site 697283006328 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 697283006329 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 697283006330 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 697283006331 putative DNA binding site [nucleotide binding]; other site 697283006332 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 697283006333 DltD N-terminal region; Region: DltD_N; pfam04915 697283006334 DltD central region; Region: DltD_M; pfam04918 697283006335 DltD C-terminal region; Region: DltD_C; pfam04914 697283006336 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 697283006337 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 697283006338 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 697283006339 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 697283006340 acyl-activating enzyme (AAE) consensus motif; other site 697283006341 AMP binding site [chemical binding]; other site 697283006342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697283006343 H+ Antiporter protein; Region: 2A0121; TIGR00900 697283006344 putative substrate translocation pore; other site 697283006345 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 697283006346 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 697283006347 putative active site [active] 697283006348 putative NTP binding site [chemical binding]; other site 697283006349 putative nucleic acid binding site [nucleotide binding]; other site 697283006350 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 697283006351 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 697283006352 amphipathic channel; other site 697283006353 Asn-Pro-Ala signature motifs; other site 697283006354 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 697283006355 glycerol kinase; Provisional; Region: glpK; PRK00047 697283006356 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 697283006357 N- and C-terminal domain interface [polypeptide binding]; other site 697283006358 active site 697283006359 MgATP binding site [chemical binding]; other site 697283006360 catalytic site [active] 697283006361 metal binding site [ion binding]; metal-binding site 697283006362 glycerol binding site [chemical binding]; other site 697283006363 homotetramer interface [polypeptide binding]; other site 697283006364 homodimer interface [polypeptide binding]; other site 697283006365 FBP binding site [chemical binding]; other site 697283006366 protein IIAGlc interface [polypeptide binding]; other site 697283006367 Mga helix-turn-helix domain; Region: Mga; pfam05043 697283006368 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 697283006369 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 697283006370 dimerization interface [polypeptide binding]; other site 697283006371 domain crossover interface; other site 697283006372 redox-dependent activation switch; other site 697283006373 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 697283006374 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 697283006375 FMN binding site [chemical binding]; other site 697283006376 active site 697283006377 catalytic residues [active] 697283006378 substrate binding site [chemical binding]; other site 697283006379 RICH domain; Region: RICH; pfam05062 697283006380 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 697283006381 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 697283006382 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 697283006383 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 697283006384 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 697283006385 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 697283006386 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 697283006387 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 697283006388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 697283006389 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 697283006390 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 697283006391 dimerization interface [polypeptide binding]; other site 697283006392 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 697283006393 dimer interface [polypeptide binding]; other site 697283006394 phosphorylation site [posttranslational modification] 697283006395 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697283006396 ATP binding site [chemical binding]; other site 697283006397 Mg2+ binding site [ion binding]; other site 697283006398 G-X-G motif; other site 697283006399 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 697283006400 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697283006401 active site 697283006402 phosphorylation site [posttranslational modification] 697283006403 intermolecular recognition site; other site 697283006404 dimerization interface [polypeptide binding]; other site 697283006405 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 697283006406 DNA binding site [nucleotide binding] 697283006407 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 697283006408 Clp amino terminal domain; Region: Clp_N; pfam02861 697283006409 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697283006410 Walker A motif; other site 697283006411 ATP binding site [chemical binding]; other site 697283006412 Walker B motif; other site 697283006413 arginine finger; other site 697283006414 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697283006415 Walker A motif; other site 697283006416 ATP binding site [chemical binding]; other site 697283006417 Walker B motif; other site 697283006418 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 697283006419 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 697283006420 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 697283006421 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 697283006422 Walker A/P-loop; other site 697283006423 ATP binding site [chemical binding]; other site 697283006424 Q-loop/lid; other site 697283006425 ABC transporter signature motif; other site 697283006426 Walker B; other site 697283006427 D-loop; other site 697283006428 H-loop/switch region; other site 697283006429 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 697283006430 NMT1/THI5 like; Region: NMT1; pfam09084 697283006431 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 697283006432 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 697283006433 putative PBP binding loops; other site 697283006434 ABC-ATPase subunit interface; other site 697283006435 Uncharacterized conserved protein [Function unknown]; Region: COG0011 697283006436 Surface antigen [General function prediction only]; Region: COG3942 697283006437 CHAP domain; Region: CHAP; pfam05257 697283006438 Bacterial SH3 domain; Region: SH3_5; pfam08460 697283006439 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 697283006440 Bacterial SH3 domain; Region: SH3_5; pfam08460 697283006441 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 697283006442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466 697283006443 replicative DNA helicase; Provisional; Region: PRK05748 697283006444 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 697283006445 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 697283006446 Walker A motif; other site 697283006447 ATP binding site [chemical binding]; other site 697283006448 Walker B motif; other site 697283006449 DNA binding loops [nucleotide binding] 697283006450 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 697283006451 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 697283006452 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 697283006453 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 697283006454 DHH family; Region: DHH; pfam01368 697283006455 DHHA1 domain; Region: DHHA1; pfam02272 697283006456 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 697283006457 30S subunit binding site; other site 697283006458 comF family protein; Region: comF; TIGR00201 697283006459 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 697283006460 active site 697283006461 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 697283006462 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 697283006463 ATP binding site [chemical binding]; other site 697283006464 putative Mg++ binding site [ion binding]; other site 697283006465 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 697283006466 nucleotide binding region [chemical binding]; other site 697283006467 ATP-binding site [chemical binding]; other site 697283006468 Uncharacterized conserved protein [Function unknown]; Region: COG1739 697283006469 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 697283006470 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 697283006471 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 697283006472 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 697283006473 dimer interface [polypeptide binding]; other site 697283006474 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697283006475 catalytic residue [active] 697283006476 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 697283006477 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 697283006478 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 697283006479 elongation factor Ts; Provisional; Region: tsf; PRK09377 697283006480 UBA/TS-N domain; Region: UBA; pfam00627 697283006481 Elongation factor TS; Region: EF_TS; pfam00889 697283006482 Elongation factor TS; Region: EF_TS; pfam00889 697283006483 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 697283006484 rRNA interaction site [nucleotide binding]; other site 697283006485 S8 interaction site; other site 697283006486 putative laminin-1 binding site; other site 697283006487 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 697283006488 Septum formation initiator; Region: DivIC; cl17659 697283006489 Surface antigen [General function prediction only]; Region: COG3942 697283006490 CHAP domain; Region: CHAP; pfam05257 697283006491 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 697283006492 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 697283006493 rod shape-determining protein MreC; Region: MreC; pfam04085 697283006494 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 697283006495 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649 697283006496 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 697283006497 Walker A/P-loop; other site 697283006498 ATP binding site [chemical binding]; other site 697283006499 Q-loop/lid; other site 697283006500 ABC transporter signature motif; other site 697283006501 Walker B; other site 697283006502 D-loop; other site 697283006503 H-loop/switch region; other site 697283006504 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650 697283006505 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 697283006506 Walker A/P-loop; other site 697283006507 ATP binding site [chemical binding]; other site 697283006508 Q-loop/lid; other site 697283006509 ABC transporter signature motif; other site 697283006510 Walker B; other site 697283006511 D-loop; other site 697283006512 H-loop/switch region; other site 697283006513 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 697283006514 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 697283006515 Helix-turn-helix domain; Region: HTH_25; pfam13413 697283006516 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 697283006517 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 697283006518 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 697283006519 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 697283006520 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 697283006521 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 697283006522 S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501 697283006523 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 697283006524 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 697283006525 Walker A/P-loop; other site 697283006526 ATP binding site [chemical binding]; other site 697283006527 Q-loop/lid; other site 697283006528 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697283006529 ABC transporter signature motif; other site 697283006530 Walker B; other site 697283006531 D-loop; other site 697283006532 H-loop/switch region; other site 697283006533 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 697283006534 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 697283006535 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 697283006536 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 697283006537 active site 697283006538 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 697283006539 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 697283006540 active site 697283006541 HIGH motif; other site 697283006542 dimer interface [polypeptide binding]; other site 697283006543 KMSKS motif; other site 697283006544 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 697283006545 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 697283006546 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 697283006547 ABC transporter; Region: ABC_tran_2; pfam12848 697283006548 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 697283006549 Predicted membrane protein [Function unknown]; Region: COG4485 697283006550 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 697283006551 Predicted membrane protein [Function unknown]; Region: COG1511 697283006552 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 697283006553 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 697283006554 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 697283006555 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 697283006556 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 697283006557 COMC family; Region: ComC; pfam03047 697283006558 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 697283006559 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 697283006560 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 697283006561 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 697283006562 protein binding site [polypeptide binding]; other site 697283006563 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 697283006564 ParB-like nuclease domain; Region: ParBc; pfam02195 697283006565 KorB domain; Region: KorB; pfam08535