-- dump date   	20140620_081033
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
208435000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
208435000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
208435000003	Walker A motif; other site
208435000004	ATP binding site [chemical binding]; other site
208435000005	Walker B motif; other site
208435000006	arginine finger; other site
208435000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
208435000008	DnaA box-binding interface [nucleotide binding]; other site
208435000009	DNA polymerase III subunit beta; Validated; Region: PRK05643
208435000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
208435000011	putative DNA binding surface [nucleotide binding]; other site
208435000012	dimer interface [polypeptide binding]; other site
208435000013	beta-clamp/clamp loader binding surface; other site
208435000014	beta-clamp/translesion DNA polymerase binding surface; other site
208435000015	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
208435000016	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
208435000017	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
208435000018	GTP-binding protein YchF; Reviewed; Region: PRK09601
208435000019	YchF GTPase; Region: YchF; cd01900
208435000020	G1 box; other site
208435000021	GTP/Mg2+ binding site [chemical binding]; other site
208435000022	Switch I region; other site
208435000023	G2 box; other site
208435000024	Switch II region; other site
208435000025	G3 box; other site
208435000026	G4 box; other site
208435000027	G5 box; other site
208435000028	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
208435000029	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
208435000030	putative active site [active]
208435000031	catalytic residue [active]
208435000032	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
208435000033	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
208435000034	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
208435000035	ATP binding site [chemical binding]; other site
208435000036	putative Mg++ binding site [ion binding]; other site
208435000037	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
208435000038	nucleotide binding region [chemical binding]; other site
208435000039	ATP-binding site [chemical binding]; other site
208435000040	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
208435000041	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
208435000042	RNA binding surface [nucleotide binding]; other site
208435000043	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
208435000044	Septum formation initiator; Region: DivIC; pfam04977
208435000045	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
208435000046	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
208435000047	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
208435000048	Ligand Binding Site [chemical binding]; other site
208435000049	TilS substrate C-terminal domain; Region: TilS_C; smart00977
208435000050	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
208435000051	active site
208435000052	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
208435000053	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
208435000054	Walker A motif; other site
208435000055	ATP binding site [chemical binding]; other site
208435000056	Walker B motif; other site
208435000057	arginine finger; other site
208435000058	Peptidase family M41; Region: Peptidase_M41; pfam01434
208435000059	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
208435000060	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
208435000061	Surface antigen [General function prediction only]; Region: COG3942
208435000062	CHAP domain; Region: CHAP; pfam05257
208435000063	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269
208435000064	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
208435000065	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
208435000066	active site
208435000067	aromatic amino acid aminotransferase; Validated; Region: PRK07309
208435000068	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
208435000069	pyridoxal 5'-phosphate binding site [chemical binding]; other site
208435000070	homodimer interface [polypeptide binding]; other site
208435000071	catalytic residue [active]
208435000072	Recombination protein O N terminal; Region: RecO_N; pfam11967
208435000073	DNA repair protein RecO; Region: reco; TIGR00613
208435000074	Recombination protein O C terminal; Region: RecO_C; pfam02565
208435000075	CAAX protease self-immunity; Region: Abi; pfam02517
208435000076	putative phosphate acyltransferase; Provisional; Region: PRK05331
208435000077	acyl carrier protein; Provisional; Region: PRK12449
208435000078	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
208435000079	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
208435000080	ATP binding site [chemical binding]; other site
208435000081	active site
208435000082	substrate binding site [chemical binding]; other site
208435000083	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
208435000084	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
208435000085	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
208435000086	dimerization interface [polypeptide binding]; other site
208435000087	ATP binding site [chemical binding]; other site
208435000088	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
208435000089	dimerization interface [polypeptide binding]; other site
208435000090	ATP binding site [chemical binding]; other site
208435000091	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
208435000092	putative active site [active]
208435000093	catalytic triad [active]
208435000094	amidophosphoribosyltransferase; Provisional; Region: PRK07272
208435000095	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
208435000096	active site
208435000097	tetramer interface [polypeptide binding]; other site
208435000098	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
208435000099	active site
208435000100	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
208435000101	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
208435000102	dimerization interface [polypeptide binding]; other site
208435000103	putative ATP binding site [chemical binding]; other site
208435000104	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
208435000105	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
208435000106	active site
208435000107	substrate binding site [chemical binding]; other site
208435000108	cosubstrate binding site; other site
208435000109	catalytic site [active]
208435000110	GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746
208435000111	Predicted acetyltransferase [General function prediction only]; Region: COG3393
208435000112	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
208435000113	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
208435000114	purine monophosphate binding site [chemical binding]; other site
208435000115	dimer interface [polypeptide binding]; other site
208435000116	putative catalytic residues [active]
208435000117	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
208435000118	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
208435000119	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
208435000120	Peptidase family M23; Region: Peptidase_M23; pfam01551
208435000121	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
208435000122	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
208435000123	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
208435000124	putative active site cavity [active]
208435000125	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
208435000126	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
208435000127	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
208435000128	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
208435000129	dimer interface [polypeptide binding]; other site
208435000130	ABC-ATPase subunit interface; other site
208435000131	putative PBP binding loops; other site
208435000132	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
208435000133	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
208435000134	dimer interface [polypeptide binding]; other site
208435000135	conserved gate region; other site
208435000136	putative PBP binding loops; other site
208435000137	ABC-ATPase subunit interface; other site
208435000138	Domain of unknown function (DUF386); Region: DUF386; cl01047
208435000139	Protein of unknown function, DUF624; Region: DUF624; pfam04854
208435000140	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
208435000141	Class I aldolases; Region: Aldolase_Class_I; cl17187
208435000142	catalytic residue [active]
208435000143	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
208435000144	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
208435000145	nucleotide binding site [chemical binding]; other site
208435000146	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
208435000147	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
208435000148	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
208435000149	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
208435000150	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
208435000151	putative active site [active]
208435000152	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
208435000153	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
208435000154	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
208435000155	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
208435000156	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
208435000157	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
208435000158	ATP-grasp domain; Region: ATP-grasp; pfam02222
208435000159	adenylosuccinate lyase; Provisional; Region: PRK07492
208435000160	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
208435000161	tetramer interface [polypeptide binding]; other site
208435000162	active site
208435000163	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
208435000164	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
208435000165	non-specific DNA binding site [nucleotide binding]; other site
208435000166	salt bridge; other site
208435000167	sequence-specific DNA binding site [nucleotide binding]; other site
208435000168	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
208435000169	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
208435000170	Walker A motif; other site
208435000171	ATP binding site [chemical binding]; other site
208435000172	Walker B motif; other site
208435000173	arginine finger; other site
208435000174	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
208435000175	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
208435000176	Low molecular weight phosphatase family; Region: LMWPc; cd00115
208435000177	active site
208435000178	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
208435000179	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
208435000180	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
208435000181	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
208435000182	active site
208435000183	catalytic triad [active]
208435000184	oxyanion hole [active]
208435000185	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
208435000186	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
208435000187	putative catalytic cysteine [active]
208435000188	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
208435000189	putative active site [active]
208435000190	metal binding site [ion binding]; metal-binding site
208435000191	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
208435000192	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
208435000193	NAD binding site [chemical binding]; other site
208435000194	substrate binding site [chemical binding]; other site
208435000195	catalytic Zn binding site [ion binding]; other site
208435000196	tetramer interface [polypeptide binding]; other site
208435000197	structural Zn binding site [ion binding]; other site
208435000198	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
208435000199	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
208435000200	pyridoxal 5'-phosphate binding site [chemical binding]; other site
208435000201	catalytic residue [active]
208435000202	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
208435000203	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
208435000204	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
208435000205	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
208435000206	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
208435000207	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
208435000208	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
208435000209	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
208435000210	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
208435000211	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
208435000212	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
208435000213	putative translocon binding site; other site
208435000214	protein-rRNA interface [nucleotide binding]; other site
208435000215	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
208435000216	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
208435000217	G-X-X-G motif; other site
208435000218	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
208435000219	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
208435000220	23S rRNA interface [nucleotide binding]; other site
208435000221	5S rRNA interface [nucleotide binding]; other site
208435000222	putative antibiotic binding site [chemical binding]; other site
208435000223	L25 interface [polypeptide binding]; other site
208435000224	L27 interface [polypeptide binding]; other site
208435000225	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
208435000226	23S rRNA interface [nucleotide binding]; other site
208435000227	putative translocon interaction site; other site
208435000228	signal recognition particle (SRP54) interaction site; other site
208435000229	L23 interface [polypeptide binding]; other site
208435000230	trigger factor interaction site; other site
208435000231	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
208435000232	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
208435000233	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
208435000234	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
208435000235	RNA binding site [nucleotide binding]; other site
208435000236	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
208435000237	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
208435000238	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
208435000239	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
208435000240	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
208435000241	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
208435000242	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
208435000243	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
208435000244	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
208435000245	5S rRNA interface [nucleotide binding]; other site
208435000246	L27 interface [polypeptide binding]; other site
208435000247	23S rRNA interface [nucleotide binding]; other site
208435000248	L5 interface [polypeptide binding]; other site
208435000249	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
208435000250	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
208435000251	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
208435000252	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
208435000253	23S rRNA binding site [nucleotide binding]; other site
208435000254	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
208435000255	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
208435000256	SecY translocase; Region: SecY; pfam00344
208435000257	adenylate kinase; Reviewed; Region: adk; PRK00279
208435000258	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
208435000259	AMP-binding site [chemical binding]; other site
208435000260	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
208435000261	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
208435000262	rRNA binding site [nucleotide binding]; other site
208435000263	predicted 30S ribosome binding site; other site
208435000264	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
208435000265	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
208435000266	30S ribosomal protein S13; Region: bact_S13; TIGR03631
208435000267	30S ribosomal protein S11; Validated; Region: PRK05309
208435000268	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
208435000269	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
208435000270	alphaNTD homodimer interface [polypeptide binding]; other site
208435000271	alphaNTD - beta interaction site [polypeptide binding]; other site
208435000272	alphaNTD - beta' interaction site [polypeptide binding]; other site
208435000273	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
208435000274	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
208435000275	Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042
208435000276	Protein of unknown function (DUF2992); Region: DUF2992; pfam11208
208435000277	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
208435000278	catalytic core [active]
208435000279	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
208435000280	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
208435000281	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
208435000282	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
208435000283	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
208435000284	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
208435000285	GrpE; Region: GrpE; pfam01025
208435000286	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
208435000287	dimer interface [polypeptide binding]; other site
208435000288	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
208435000289	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
208435000290	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
208435000291	nucleotide binding site [chemical binding]; other site
208435000292	NEF interaction site [polypeptide binding]; other site
208435000293	SBD interface [polypeptide binding]; other site
208435000294	chaperone protein DnaJ; Provisional; Region: PRK14276
208435000295	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
208435000296	HSP70 interaction site [polypeptide binding]; other site
208435000297	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
208435000298	substrate binding site [polypeptide binding]; other site
208435000299	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
208435000300	Zn binding sites [ion binding]; other site
208435000301	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
208435000302	dimer interface [polypeptide binding]; other site
208435000303	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
208435000304	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
208435000305	DNA-binding site [nucleotide binding]; DNA binding site
208435000306	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
208435000307	pyridoxal 5'-phosphate binding site [chemical binding]; other site
208435000308	homodimer interface [polypeptide binding]; other site
208435000309	catalytic residue [active]
208435000310	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
208435000311	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
208435000312	dimerization interface 3.5A [polypeptide binding]; other site
208435000313	active site
208435000314	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
208435000315	dimer interface [polypeptide binding]; other site
208435000316	substrate binding site [chemical binding]; other site
208435000317	ATP binding site [chemical binding]; other site
208435000318	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
208435000319	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
208435000320	hypothetical protein; Provisional; Region: PRK13690
208435000321	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
208435000322	Mechanosensitive ion channel; Region: MS_channel; pfam00924
208435000323	trigger factor; Provisional; Region: tig; PRK01490
208435000324	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
208435000325	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
208435000326	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
208435000327	CTP synthetase; Validated; Region: pyrG; PRK05380
208435000328	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
208435000329	Catalytic site [active]
208435000330	active site
208435000331	UTP binding site [chemical binding]; other site
208435000332	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
208435000333	active site
208435000334	putative oxyanion hole; other site
208435000335	catalytic triad [active]
208435000336	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
208435000337	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
208435000338	trimer interface [polypeptide binding]; other site
208435000339	active site
208435000340	DNA repair protein RadA; Provisional; Region: PRK11823
208435000341	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
208435000342	Walker A motif/ATP binding site; other site
208435000343	ATP binding site [chemical binding]; other site
208435000344	Walker B motif; other site
208435000345	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
208435000346	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
208435000347	active site clefts [active]
208435000348	zinc binding site [ion binding]; other site
208435000349	dimer interface [polypeptide binding]; other site
208435000350	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
208435000351	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
208435000352	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
208435000353	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
208435000354	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
208435000355	active site
208435000356	HIGH motif; other site
208435000357	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
208435000358	active site
208435000359	KMSKS motif; other site
208435000360	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
208435000361	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
208435000362	ligand binding site [chemical binding]; other site
208435000363	dimerization interface [polypeptide binding]; other site
208435000364	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
208435000365	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
208435000366	TM-ABC transporter signature motif; other site
208435000367	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
208435000368	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
208435000369	Walker A/P-loop; other site
208435000370	ATP binding site [chemical binding]; other site
208435000371	Q-loop/lid; other site
208435000372	ABC transporter signature motif; other site
208435000373	Walker B; other site
208435000374	D-loop; other site
208435000375	H-loop/switch region; other site
208435000376	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
208435000377	D-ribose pyranase; Provisional; Region: PRK11797
208435000378	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
208435000379	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
208435000380	substrate binding site [chemical binding]; other site
208435000381	dimer interface [polypeptide binding]; other site
208435000382	ATP binding site [chemical binding]; other site
208435000383	Transcriptional regulators [Transcription]; Region: PurR; COG1609
208435000384	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
208435000385	DNA binding site [nucleotide binding]
208435000386	domain linker motif; other site
208435000387	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
208435000388	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
208435000389	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
208435000390	FtsX-like permease family; Region: FtsX; pfam02687
208435000391	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
208435000392	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
208435000393	Walker A/P-loop; other site
208435000394	ATP binding site [chemical binding]; other site
208435000395	Q-loop/lid; other site
208435000396	ABC transporter signature motif; other site
208435000397	Walker B; other site
208435000398	D-loop; other site
208435000399	H-loop/switch region; other site
208435000400	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
208435000401	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
208435000402	active site
208435000403	phosphorylation site [posttranslational modification]
208435000404	intermolecular recognition site; other site
208435000405	dimerization interface [polypeptide binding]; other site
208435000406	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
208435000407	DNA binding site [nucleotide binding]
208435000408	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
208435000409	HAMP domain; Region: HAMP; pfam00672
208435000410	dimerization interface [polypeptide binding]; other site
208435000411	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
208435000412	dimer interface [polypeptide binding]; other site
208435000413	phosphorylation site [posttranslational modification]
208435000414	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
208435000415	ATP binding site [chemical binding]; other site
208435000416	Mg2+ binding site [ion binding]; other site
208435000417	G-X-G motif; other site
208435000418	argininosuccinate synthase; Provisional; Region: PRK13820
208435000419	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
208435000420	ANP binding site [chemical binding]; other site
208435000421	Substrate Binding Site II [chemical binding]; other site
208435000422	Substrate Binding Site I [chemical binding]; other site
208435000423	argininosuccinate lyase; Provisional; Region: PRK00855
208435000424	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
208435000425	active sites [active]
208435000426	tetramer interface [polypeptide binding]; other site
208435000427	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
208435000428	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
208435000429	intersubunit interface [polypeptide binding]; other site
208435000430	active site
208435000431	zinc binding site [ion binding]; other site
208435000432	Na+ binding site [ion binding]; other site
208435000433	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
208435000434	tetramer (dimer of dimers) interface [polypeptide binding]; other site
208435000435	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
208435000436	NAD binding site [chemical binding]; other site
208435000437	dimer interface [polypeptide binding]; other site
208435000438	substrate binding site [chemical binding]; other site
208435000439	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
208435000440	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
208435000441	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
208435000442	DAK2 domain; Region: Dak2; pfam02734
208435000443	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
208435000444	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_4; cd03407
208435000445	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
208435000446	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
208435000447	Walker A/P-loop; other site
208435000448	ATP binding site [chemical binding]; other site
208435000449	Q-loop/lid; other site
208435000450	ABC transporter signature motif; other site
208435000451	Walker B; other site
208435000452	D-loop; other site
208435000453	H-loop/switch region; other site
208435000454	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
208435000455	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
208435000456	substrate binding pocket [chemical binding]; other site
208435000457	membrane-bound complex binding site; other site
208435000458	hinge residues; other site
208435000459	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
208435000460	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
208435000461	dimer interface [polypeptide binding]; other site
208435000462	conserved gate region; other site
208435000463	putative PBP binding loops; other site
208435000464	ABC-ATPase subunit interface; other site
208435000465	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
208435000466	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
208435000467	adaptor protein; Provisional; Region: PRK02315
208435000468	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
208435000469	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
208435000470	Mg++ binding site [ion binding]; other site
208435000471	putative catalytic motif [active]
208435000472	substrate binding site [chemical binding]; other site
208435000473	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
208435000474	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
208435000475	Walker A/P-loop; other site
208435000476	ATP binding site [chemical binding]; other site
208435000477	Q-loop/lid; other site
208435000478	ABC transporter signature motif; other site
208435000479	Walker B; other site
208435000480	D-loop; other site
208435000481	H-loop/switch region; other site
208435000482	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
208435000483	FeS assembly protein SufD; Region: sufD; TIGR01981
208435000484	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
208435000485	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
208435000486	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
208435000487	catalytic residue [active]
208435000488	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
208435000489	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
208435000490	trimerization site [polypeptide binding]; other site
208435000491	active site
208435000492	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
208435000493	FeS assembly protein SufB; Region: sufB; TIGR01980
208435000494	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
208435000495	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
208435000496	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
208435000497	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
208435000498	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
208435000499	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
208435000500	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
208435000501	peptide binding site [polypeptide binding]; other site
208435000502	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
208435000503	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
208435000504	dimer interface [polypeptide binding]; other site
208435000505	conserved gate region; other site
208435000506	putative PBP binding loops; other site
208435000507	ABC-ATPase subunit interface; other site
208435000508	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
208435000509	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
208435000510	dimer interface [polypeptide binding]; other site
208435000511	conserved gate region; other site
208435000512	putative PBP binding loops; other site
208435000513	ABC-ATPase subunit interface; other site
208435000514	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
208435000515	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
208435000516	Walker A/P-loop; other site
208435000517	ATP binding site [chemical binding]; other site
208435000518	Q-loop/lid; other site
208435000519	ABC transporter signature motif; other site
208435000520	Walker B; other site
208435000521	D-loop; other site
208435000522	H-loop/switch region; other site
208435000523	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
208435000524	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
208435000525	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
208435000526	Walker A/P-loop; other site
208435000527	ATP binding site [chemical binding]; other site
208435000528	Q-loop/lid; other site
208435000529	ABC transporter signature motif; other site
208435000530	Walker B; other site
208435000531	D-loop; other site
208435000532	H-loop/switch region; other site
208435000533	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
208435000534	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
208435000535	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
208435000536	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
208435000537	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
208435000538	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
208435000539	putative Zn2+ binding site [ion binding]; other site
208435000540	putative DNA binding site [nucleotide binding]; other site
208435000541	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
208435000542	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
208435000543	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
208435000544	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
208435000545	ABC-ATPase subunit  interface; other site
208435000546	dimer interface [polypeptide binding]; other site
208435000547	putative PBP binding regions; other site
208435000548	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
208435000549	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
208435000550	active site
208435000551	HIGH motif; other site
208435000552	dimer interface [polypeptide binding]; other site
208435000553	KMSKS motif; other site
208435000554	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
208435000555	RNA binding surface [nucleotide binding]; other site
208435000556	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
208435000557	Transglycosylase; Region: Transgly; pfam00912
208435000558	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
208435000559	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
208435000560	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
208435000561	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
208435000562	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
208435000563	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
208435000564	RPB1 interaction site [polypeptide binding]; other site
208435000565	RPB10 interaction site [polypeptide binding]; other site
208435000566	RPB11 interaction site [polypeptide binding]; other site
208435000567	RPB3 interaction site [polypeptide binding]; other site
208435000568	RPB12 interaction site [polypeptide binding]; other site
208435000569	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
208435000570	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
208435000571	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
208435000572	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
208435000573	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
208435000574	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
208435000575	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
208435000576	G-loop; other site
208435000577	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
208435000578	DNA binding site [nucleotide binding]
208435000579	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
208435000580	Protein of unknown function (DUF1033); Region: DUF1033; pfam06279
208435000581	Type II/IV secretion system protein; Region: T2SE; pfam00437
208435000582	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
208435000583	Walker A motif; other site
208435000584	ATP binding site [chemical binding]; other site
208435000585	Walker B motif; other site
208435000586	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
208435000587	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
208435000588	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
208435000589	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
208435000590	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
208435000591	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
208435000592	S-adenosylmethionine binding site [chemical binding]; other site
208435000593	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
208435000594	propionate/acetate kinase; Provisional; Region: PRK12379
208435000595	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
208435000596	non-specific DNA binding site [nucleotide binding]; other site
208435000597	salt bridge; other site
208435000598	sequence-specific DNA binding site [nucleotide binding]; other site
208435000599	CAAX protease self-immunity; Region: Abi; pfam02517
208435000600	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
208435000601	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
208435000602	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
208435000603	M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638
208435000604	oligomer interface [polypeptide binding]; other site
208435000605	active site
208435000606	metal binding site [ion binding]; metal-binding site
208435000607	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
208435000608	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
208435000609	catalytic residues [active]
208435000610	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
208435000611	putative tRNA-binding site [nucleotide binding]; other site
208435000612	Methyltransferase domain; Region: Methyltransf_23; pfam13489
208435000613	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
208435000614	S-adenosylmethionine binding site [chemical binding]; other site
208435000615	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
208435000616	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
208435000617	dimer interface [polypeptide binding]; other site
208435000618	ssDNA binding site [nucleotide binding]; other site
208435000619	tetramer (dimer of dimers) interface [polypeptide binding]; other site
208435000620	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
208435000621	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
208435000622	motif II; other site
208435000623	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
208435000624	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
208435000625	GAF domain; Region: GAF_3; pfam13492
208435000626	Histidine kinase; Region: His_kinase; pfam06580
208435000627	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
208435000628	ATP binding site [chemical binding]; other site
208435000629	Mg2+ binding site [ion binding]; other site
208435000630	G-X-G motif; other site
208435000631	two-component response regulator; Provisional; Region: PRK14084
208435000632	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
208435000633	active site
208435000634	phosphorylation site [posttranslational modification]
208435000635	intermolecular recognition site; other site
208435000636	dimerization interface [polypeptide binding]; other site
208435000637	LytTr DNA-binding domain; Region: LytTR; pfam04397
208435000638	LrgA family; Region: LrgA; cl00608
208435000639	LrgB-like family; Region: LrgB; cl00596
208435000640	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
208435000641	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518
208435000642	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
208435000643	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
208435000644	dimer interface [polypeptide binding]; other site
208435000645	conserved gate region; other site
208435000646	putative PBP binding loops; other site
208435000647	ABC-ATPase subunit interface; other site
208435000648	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
208435000649	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
208435000650	dimer interface [polypeptide binding]; other site
208435000651	conserved gate region; other site
208435000652	putative PBP binding loops; other site
208435000653	ABC-ATPase subunit interface; other site
208435000654	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
208435000655	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
208435000656	Walker A/P-loop; other site
208435000657	ATP binding site [chemical binding]; other site
208435000658	Q-loop/lid; other site
208435000659	ABC transporter signature motif; other site
208435000660	Walker B; other site
208435000661	D-loop; other site
208435000662	H-loop/switch region; other site
208435000663	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
208435000664	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
208435000665	Walker A/P-loop; other site
208435000666	ATP binding site [chemical binding]; other site
208435000667	Q-loop/lid; other site
208435000668	ABC transporter signature motif; other site
208435000669	Walker B; other site
208435000670	D-loop; other site
208435000671	H-loop/switch region; other site
208435000672	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
208435000673	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
208435000674	active site turn [active]
208435000675	phosphorylation site [posttranslational modification]
208435000676	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
208435000677	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
208435000678	HPr interaction site; other site
208435000679	glycerol kinase (GK) interaction site [polypeptide binding]; other site
208435000680	active site
208435000681	phosphorylation site [posttranslational modification]
208435000682	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
208435000683	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
208435000684	Ca binding site [ion binding]; other site
208435000685	active site
208435000686	catalytic site [active]
208435000687	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
208435000688	PRD domain; Region: PRD; pfam00874
208435000689	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
208435000690	active site
208435000691	P-loop; other site
208435000692	phosphorylation site [posttranslational modification]
208435000693	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
208435000694	active site
208435000695	phosphorylation site [posttranslational modification]
208435000696	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
208435000697	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
208435000698	Transposase [DNA replication, recombination, and repair]; Region: COG5433
208435000699	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
208435000700	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
208435000701	active site
208435000702	P-loop; other site
208435000703	phosphorylation site [posttranslational modification]
208435000704	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
208435000705	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
208435000706	TPP-binding site [chemical binding]; other site
208435000707	dimer interface [polypeptide binding]; other site
208435000708	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
208435000709	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
208435000710	PYR/PP interface [polypeptide binding]; other site
208435000711	dimer interface [polypeptide binding]; other site
208435000712	TPP binding site [chemical binding]; other site
208435000713	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
208435000714	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
208435000715	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
208435000716	FAD binding pocket [chemical binding]; other site
208435000717	FAD binding motif [chemical binding]; other site
208435000718	phosphate binding motif [ion binding]; other site
208435000719	beta-alpha-beta structure motif; other site
208435000720	NAD binding pocket [chemical binding]; other site
208435000721	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
208435000722	16S/18S rRNA binding site [nucleotide binding]; other site
208435000723	S13e-L30e interaction site [polypeptide binding]; other site
208435000724	25S rRNA binding site [nucleotide binding]; other site
208435000725	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
208435000726	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
208435000727	RNase E interface [polypeptide binding]; other site
208435000728	trimer interface [polypeptide binding]; other site
208435000729	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
208435000730	RNase E interface [polypeptide binding]; other site
208435000731	trimer interface [polypeptide binding]; other site
208435000732	active site
208435000733	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
208435000734	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
208435000735	RNA binding site [nucleotide binding]; other site
208435000736	domain interface; other site
208435000737	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
208435000738	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
208435000739	trimer interface [polypeptide binding]; other site
208435000740	active site
208435000741	substrate binding site [chemical binding]; other site
208435000742	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
208435000743	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
208435000744	active site
208435000745	HIGH motif; other site
208435000746	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
208435000747	KMSKS motif; other site
208435000748	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
208435000749	tRNA binding surface [nucleotide binding]; other site
208435000750	anticodon binding site; other site
208435000751	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
208435000752	active site
208435000753	metal binding site [ion binding]; metal-binding site
208435000754	dimerization interface [polypeptide binding]; other site
208435000755	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
208435000756	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
208435000757	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
208435000758	YacP-like NYN domain; Region: NYN_YacP; cl01491
208435000759	EDD domain protein, DegV family; Region: DegV; TIGR00762
208435000760	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
208435000761	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
208435000762	23S rRNA interface [nucleotide binding]; other site
208435000763	L3 interface [polypeptide binding]; other site
208435000764	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
208435000765	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
208435000766	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
208435000767	Int/Topo IB signature motif; other site
208435000768	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
208435000769	non-specific DNA binding site [nucleotide binding]; other site
208435000770	salt bridge; other site
208435000771	sequence-specific DNA binding site [nucleotide binding]; other site
208435000772	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
208435000773	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
208435000774	Replication initiation factor; Region: Rep_trans; pfam02486
208435000775	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
208435000776	addiction module toxin, RelE/StbE family; Region: RelE_StbE; TIGR02385
208435000777	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
208435000778	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
208435000779	non-specific DNA binding site [nucleotide binding]; other site
208435000780	salt bridge; other site
208435000781	sequence-specific DNA binding site [nucleotide binding]; other site
208435000782	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
208435000783	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
208435000784	H+ Antiporter protein; Region: 2A0121; TIGR00900
208435000785	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
208435000786	dimer interface [polypeptide binding]; other site
208435000787	conserved gate region; other site
208435000788	ABC-ATPase subunit interface; other site
208435000789	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
208435000790	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
208435000791	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
208435000792	dimer interface [polypeptide binding]; other site
208435000793	conserved gate region; other site
208435000794	putative PBP binding loops; other site
208435000795	ABC-ATPase subunit interface; other site
208435000796	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
208435000797	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
208435000798	Walker A/P-loop; other site
208435000799	ATP binding site [chemical binding]; other site
208435000800	Q-loop/lid; other site
208435000801	ABC transporter signature motif; other site
208435000802	Walker B; other site
208435000803	D-loop; other site
208435000804	H-loop/switch region; other site
208435000805	FOG: CBS domain [General function prediction only]; Region: COG0517
208435000806	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
208435000807	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
208435000808	nucleophilic elbow; other site
208435000809	catalytic triad; other site
208435000810	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
208435000811	non-specific DNA binding site [nucleotide binding]; other site
208435000812	salt bridge; other site
208435000813	sequence-specific DNA binding site [nucleotide binding]; other site
208435000814	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
208435000815	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
208435000816	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
208435000817	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
208435000818	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
208435000819	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
208435000820	Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791
208435000821	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
208435000822	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
208435000823	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
208435000824	DNA binding residues [nucleotide binding]
208435000825	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
208435000826	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
208435000827	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
208435000828	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
208435000829	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
208435000830	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
208435000831	Walker A/P-loop; other site
208435000832	ATP binding site [chemical binding]; other site
208435000833	Q-loop/lid; other site
208435000834	ABC transporter signature motif; other site
208435000835	Walker B; other site
208435000836	D-loop; other site
208435000837	H-loop/switch region; other site
208435000838	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
208435000839	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
208435000840	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
208435000841	Predicted transcriptional regulators [Transcription]; Region: COG1695
208435000842	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
208435000843	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
208435000844	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
208435000845	active site
208435000846	dimer interface [polypeptide binding]; other site
208435000847	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
208435000848	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
208435000849	dimer interface [polypeptide binding]; other site
208435000850	motif 1; other site
208435000851	active site
208435000852	motif 2; other site
208435000853	motif 3; other site
208435000854	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
208435000855	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
208435000856	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
208435000857	DALR anticodon binding domain; Region: DALR_1; pfam05746
208435000858	hypothetical protein; Provisional; Region: PRK02539
208435000859	Predicted membrane protein [Function unknown]; Region: COG3326
208435000860	glycerol kinase; Provisional; Region: glpK; PRK00047
208435000861	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
208435000862	N- and C-terminal domain interface [polypeptide binding]; other site
208435000863	active site
208435000864	MgATP binding site [chemical binding]; other site
208435000865	catalytic site [active]
208435000866	metal binding site [ion binding]; metal-binding site
208435000867	glycerol binding site [chemical binding]; other site
208435000868	homotetramer interface [polypeptide binding]; other site
208435000869	homodimer interface [polypeptide binding]; other site
208435000870	FBP binding site [chemical binding]; other site
208435000871	protein IIAGlc interface [polypeptide binding]; other site
208435000872	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
208435000873	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
208435000874	amphipathic channel; other site
208435000875	Asn-Pro-Ala signature motifs; other site
208435000876	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
208435000877	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
208435000878	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
208435000879	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
208435000880	Mga helix-turn-helix domain; Region: Mga; pfam05043
208435000881	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
208435000882	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
208435000883	TPP-binding site [chemical binding]; other site
208435000884	dimer interface [polypeptide binding]; other site
208435000885	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
208435000886	PYR/PP interface [polypeptide binding]; other site
208435000887	dimer interface [polypeptide binding]; other site
208435000888	TPP binding site [chemical binding]; other site
208435000889	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
208435000890	Enterocin A Immunity; Region: EntA_Immun; pfam08951
208435000891	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
208435000892	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
208435000893	Walker A/P-loop; other site
208435000894	ATP binding site [chemical binding]; other site
208435000895	Q-loop/lid; other site
208435000896	ABC transporter signature motif; other site
208435000897	Walker B; other site
208435000898	D-loop; other site
208435000899	H-loop/switch region; other site
208435000900	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
208435000901	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
208435000902	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
208435000903	active site turn [active]
208435000904	phosphorylation site [posttranslational modification]
208435000905	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
208435000906	Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263
208435000907	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
208435000908	nucleotide binding site [chemical binding]; other site
208435000909	homotetrameric interface [polypeptide binding]; other site
208435000910	putative phosphate binding site [ion binding]; other site
208435000911	putative allosteric binding site; other site
208435000912	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
208435000913	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
208435000914	putative catalytic cysteine [active]
208435000915	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
208435000916	MraW methylase family; Region: Methyltransf_5; pfam01795
208435000917	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
208435000918	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
208435000919	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
208435000920	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
208435000921	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
208435000922	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
208435000923	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
208435000924	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
208435000925	Mg++ binding site [ion binding]; other site
208435000926	putative catalytic motif [active]
208435000927	putative substrate binding site [chemical binding]; other site
208435000928	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
208435000929	DEAD-like helicases superfamily; Region: DEXDc; smart00487
208435000930	ATP binding site [chemical binding]; other site
208435000931	Mg++ binding site [ion binding]; other site
208435000932	motif III; other site
208435000933	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
208435000934	nucleotide binding region [chemical binding]; other site
208435000935	ATP-binding site [chemical binding]; other site
208435000936	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
208435000937	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
208435000938	substrate binding pocket [chemical binding]; other site
208435000939	membrane-bound complex binding site; other site
208435000940	hinge residues; other site
208435000941	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
208435000942	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
208435000943	dimer interface [polypeptide binding]; other site
208435000944	conserved gate region; other site
208435000945	putative PBP binding loops; other site
208435000946	ABC-ATPase subunit interface; other site
208435000947	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
208435000948	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
208435000949	Walker A/P-loop; other site
208435000950	ATP binding site [chemical binding]; other site
208435000951	Q-loop/lid; other site
208435000952	ABC transporter signature motif; other site
208435000953	Walker B; other site
208435000954	D-loop; other site
208435000955	H-loop/switch region; other site
208435000956	Protein of unknown function (DUF4059); Region: DUF4059; pfam13268
208435000957	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
208435000958	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
208435000959	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
208435000960	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
208435000961	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
208435000962	active site
208435000963	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
208435000964	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
208435000965	homodimer interface [polypeptide binding]; other site
208435000966	NAD binding pocket [chemical binding]; other site
208435000967	ATP binding pocket [chemical binding]; other site
208435000968	Mg binding site [ion binding]; other site
208435000969	active-site loop [active]
208435000970	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
208435000971	trimer interface [polypeptide binding]; other site
208435000972	active site
208435000973	G bulge; other site
208435000974	Transglycosylase; Region: Transgly; pfam00912
208435000975	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
208435000976	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
208435000977	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
208435000978	hypothetical protein; Provisional; Region: PRK13660
208435000979	cell division protein GpsB; Provisional; Region: PRK14127
208435000980	DivIVA domain; Region: DivI1A_domain; TIGR03544
208435000981	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
208435000982	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
208435000983	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
208435000984	S-ribosylhomocysteinase; Provisional; Region: PRK02260
208435000985	hypothetical protein; Provisional; Region: PRK00106
208435000986	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
208435000987	Zn2+ binding site [ion binding]; other site
208435000988	Mg2+ binding site [ion binding]; other site
208435000989	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
208435000990	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
208435000991	Walker A/P-loop; other site
208435000992	ATP binding site [chemical binding]; other site
208435000993	Q-loop/lid; other site
208435000994	ABC transporter signature motif; other site
208435000995	Walker B; other site
208435000996	D-loop; other site
208435000997	H-loop/switch region; other site
208435000998	ABC-2 type transporter; Region: ABC2_membrane; cl17235
208435000999	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
208435001000	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
208435001001	Cytidylyltransferase family; Region: CTP_transf_1; cl17467
208435001002	Histidine kinase; Region: HisKA_3; pfam07730
208435001003	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
208435001004	Mg2+ binding site [ion binding]; other site
208435001005	G-X-G motif; other site
208435001006	Protein of unknown function (DUF1211); Region: DUF1211; pfam06736
208435001007	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
208435001008	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
208435001009	catalytic site [active]
208435001010	G-X2-G-X-G-K; other site
208435001011	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
208435001012	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
208435001013	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
208435001014	ATP binding site [chemical binding]; other site
208435001015	putative Mg++ binding site [ion binding]; other site
208435001016	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
208435001017	ATP-binding site [chemical binding]; other site
208435001018	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
208435001019	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
208435001020	putative active site [active]
208435001021	substrate binding site [chemical binding]; other site
208435001022	putative cosubstrate binding site; other site
208435001023	catalytic site [active]
208435001024	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
208435001025	substrate binding site [chemical binding]; other site
208435001026	16S rRNA methyltransferase B; Provisional; Region: PRK14902
208435001027	NusB family; Region: NusB; pfam01029
208435001028	putative RNA binding site [nucleotide binding]; other site
208435001029	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
208435001030	S-adenosylmethionine binding site [chemical binding]; other site
208435001031	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
208435001032	active site
208435001033	Protein phosphatase 2C; Region: PP2C; pfam00481
208435001034	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
208435001035	Catalytic domain of Protein Kinases; Region: PKc; cd00180
208435001036	active site
208435001037	ATP binding site [chemical binding]; other site
208435001038	substrate binding site [chemical binding]; other site
208435001039	activation loop (A-loop); other site
208435001040	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
208435001041	PASTA domain; Region: PASTA; smart00740
208435001042	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
208435001043	Predicted membrane protein [Function unknown]; Region: COG4758
208435001044	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
208435001045	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
208435001046	Histidine kinase; Region: HisKA_3; pfam07730
208435001047	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
208435001048	ATP binding site [chemical binding]; other site
208435001049	Mg2+ binding site [ion binding]; other site
208435001050	G-X-G motif; other site
208435001051	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
208435001052	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
208435001053	active site
208435001054	phosphorylation site [posttranslational modification]
208435001055	intermolecular recognition site; other site
208435001056	dimerization interface [polypeptide binding]; other site
208435001057	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
208435001058	DNA binding residues [nucleotide binding]
208435001059	dimerization interface [polypeptide binding]; other site
208435001060	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
208435001061	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
208435001062	active site
208435001063	motif I; other site
208435001064	motif II; other site
208435001065	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
208435001066	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
208435001067	active site
208435001068	general stress protein 13; Validated; Region: PRK08059
208435001069	hypothetical protein; Provisional; Region: PRK07252
208435001070	RNA binding site [nucleotide binding]; other site
208435001071	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
208435001072	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
208435001073	FeS/SAM binding site; other site
208435001074	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
208435001075	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
208435001076	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
208435001077	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
208435001078	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
208435001079	DNA binding residues [nucleotide binding]
208435001080	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
208435001081	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
208435001082	active site
208435001083	methionine cluster; other site
208435001084	phosphorylation site [posttranslational modification]
208435001085	metal binding site [ion binding]; metal-binding site
208435001086	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
208435001087	active site
208435001088	P-loop; other site
208435001089	phosphorylation site [posttranslational modification]
208435001090	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
208435001091	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
208435001092	Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882
208435001093	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
208435001094	dimer interface [polypeptide binding]; other site
208435001095	active site
208435001096	glycine loop; other site
208435001097	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
208435001098	active site
208435001099	intersubunit interactions; other site
208435001100	catalytic residue [active]
208435001101	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
208435001102	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
208435001103	dimer interface [polypeptide binding]; other site
208435001104	active site
208435001105	metal binding site [ion binding]; metal-binding site
208435001106	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
208435001107	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
208435001108	dimer interface [polypeptide binding]; other site
208435001109	pyridoxal 5'-phosphate binding site [chemical binding]; other site
208435001110	catalytic residue [active]
208435001111	Uncharacterized conserved protein [Function unknown]; Region: COG1739
208435001112	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
208435001113	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
208435001114	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
208435001115	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
208435001116	ATP binding site [chemical binding]; other site
208435001117	putative Mg++ binding site [ion binding]; other site
208435001118	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
208435001119	nucleotide binding region [chemical binding]; other site
208435001120	ATP-binding site [chemical binding]; other site
208435001121	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
208435001122	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
208435001123	active site
208435001124	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
208435001125	30S subunit binding site; other site
208435001126	aspartate kinase; Reviewed; Region: PRK09034
208435001127	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
208435001128	putative catalytic residues [active]
208435001129	putative nucleotide binding site [chemical binding]; other site
208435001130	putative aspartate binding site [chemical binding]; other site
208435001131	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
208435001132	allosteric regulatory residue; other site
208435001133	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
208435001134	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
208435001135	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
208435001136	motif II; other site
208435001137	enoyl-CoA hydratase; Provisional; Region: PRK07260
208435001138	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
208435001139	substrate binding site [chemical binding]; other site
208435001140	oxyanion hole (OAH) forming residues; other site
208435001141	trimer interface [polypeptide binding]; other site
208435001142	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
208435001143	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
208435001144	putative Zn2+ binding site [ion binding]; other site
208435001145	putative DNA binding site [nucleotide binding]; other site
208435001146	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
208435001147	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
208435001148	dimer interface [polypeptide binding]; other site
208435001149	active site
208435001150	CoA binding pocket [chemical binding]; other site
208435001151	acyl carrier protein; Provisional; Region: acpP; PRK00982
208435001152	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
208435001153	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
208435001154	FMN binding site [chemical binding]; other site
208435001155	substrate binding site [chemical binding]; other site
208435001156	putative catalytic residue [active]
208435001157	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
208435001158	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
208435001159	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
208435001160	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
208435001161	NAD(P) binding site [chemical binding]; other site
208435001162	homotetramer interface [polypeptide binding]; other site
208435001163	homodimer interface [polypeptide binding]; other site
208435001164	active site
208435001165	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
208435001166	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
208435001167	dimer interface [polypeptide binding]; other site
208435001168	active site
208435001169	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
208435001170	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
208435001171	carboxyltransferase (CT) interaction site; other site
208435001172	biotinylation site [posttranslational modification]; other site
208435001173	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
208435001174	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
208435001175	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
208435001176	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
208435001177	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
208435001178	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
208435001179	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
208435001180	acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319
208435001181	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
208435001182	seryl-tRNA synthetase; Provisional; Region: PRK05431
208435001183	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
208435001184	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
208435001185	dimer interface [polypeptide binding]; other site
208435001186	active site
208435001187	motif 1; other site
208435001188	motif 2; other site
208435001189	motif 3; other site
208435001190	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
208435001191	Acyltransferase family; Region: Acyl_transf_3; pfam01757
208435001192	Domain of unknown function (DUF956); Region: DUF956; pfam06115
208435001193	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
208435001194	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
208435001195	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
208435001196	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
208435001197	active pocket/dimerization site; other site
208435001198	active site
208435001199	phosphorylation site [posttranslational modification]
208435001200	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
208435001201	active site
208435001202	phosphorylation site [posttranslational modification]
208435001203	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
208435001204	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
208435001205	active site
208435001206	motif I; other site
208435001207	motif II; other site
208435001208	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
208435001209	Protein of unknown function (DUF1361); Region: DUF1361; pfam07099
208435001210	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
208435001211	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
208435001212	pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585
208435001213	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
208435001214	Coenzyme A binding pocket [chemical binding]; other site
208435001215	Transcriptional regulator [Transcription]; Region: LytR; COG1316
208435001216	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
208435001217	HIT family signature motif; other site
208435001218	catalytic residue [active]
208435001219	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
208435001220	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
208435001221	Walker A/P-loop; other site
208435001222	ATP binding site [chemical binding]; other site
208435001223	Q-loop/lid; other site
208435001224	ABC transporter signature motif; other site
208435001225	Walker B; other site
208435001226	D-loop; other site
208435001227	H-loop/switch region; other site
208435001228	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
208435001229	Phosphotransferase enzyme family; Region: APH; pfam01636
208435001230	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
208435001231	active site
208435001232	ATP binding site [chemical binding]; other site
208435001233	substrate binding site [chemical binding]; other site
208435001234	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
208435001235	S-adenosylmethionine binding site [chemical binding]; other site
208435001236	ribosome maturation protein RimP; Reviewed; Region: PRK00092
208435001237	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
208435001238	putative oligomer interface [polypeptide binding]; other site
208435001239	putative RNA binding site [nucleotide binding]; other site
208435001240	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
208435001241	NusA N-terminal domain; Region: NusA_N; pfam08529
208435001242	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
208435001243	RNA binding site [nucleotide binding]; other site
208435001244	homodimer interface [polypeptide binding]; other site
208435001245	NusA-like KH domain; Region: KH_5; pfam13184
208435001246	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
208435001247	G-X-X-G motif; other site
208435001248	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
208435001249	putative RNA binding cleft [nucleotide binding]; other site
208435001250	hypothetical protein; Provisional; Region: PRK07283
208435001251	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
208435001252	translation initiation factor IF-2; Region: IF-2; TIGR00487
208435001253	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
208435001254	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
208435001255	G1 box; other site
208435001256	putative GEF interaction site [polypeptide binding]; other site
208435001257	GTP/Mg2+ binding site [chemical binding]; other site
208435001258	Switch I region; other site
208435001259	G2 box; other site
208435001260	G3 box; other site
208435001261	Switch II region; other site
208435001262	G4 box; other site
208435001263	G5 box; other site
208435001264	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
208435001265	Translation-initiation factor 2; Region: IF-2; pfam11987
208435001266	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
208435001267	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
208435001268	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
208435001269	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
208435001270	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
208435001271	Penicillinase repressor; Region: Pencillinase_R; pfam03965
208435001272	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
208435001273	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
208435001274	metal-binding site [ion binding]
208435001275	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
208435001276	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
208435001277	motif II; other site
208435001278	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
208435001279	metal-binding site [ion binding]
208435001280	Predicted membrane protein [Function unknown]; Region: COG2860
208435001281	UPF0126 domain; Region: UPF0126; pfam03458
208435001282	UPF0126 domain; Region: UPF0126; pfam03458
208435001283	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
208435001284	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
208435001285	active site
208435001286	motif I; other site
208435001287	motif II; other site
208435001288	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
208435001289	DNA polymerase I; Provisional; Region: PRK05755
208435001290	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
208435001291	active site
208435001292	metal binding site 1 [ion binding]; metal-binding site
208435001293	putative 5' ssDNA interaction site; other site
208435001294	metal binding site 3; metal-binding site
208435001295	metal binding site 2 [ion binding]; metal-binding site
208435001296	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
208435001297	putative DNA binding site [nucleotide binding]; other site
208435001298	putative metal binding site [ion binding]; other site
208435001299	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
208435001300	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
208435001301	active site
208435001302	DNA binding site [nucleotide binding]
208435001303	catalytic site [active]
208435001304	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
208435001305	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
208435001306	metal binding site 2 [ion binding]; metal-binding site
208435001307	putative DNA binding helix; other site
208435001308	metal binding site 1 [ion binding]; metal-binding site
208435001309	dimer interface [polypeptide binding]; other site
208435001310	structural Zn2+ binding site [ion binding]; other site
208435001311	YSIRK type signal peptide; Region: YSIRK_signal; cl04650
208435001312	Fibronectin-binding repeat; Region: SSURE; pfam11966
208435001313	Fibronectin-binding repeat; Region: SSURE; pfam11966
208435001314	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
208435001315	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
208435001316	active site
208435001317	phosphorylation site [posttranslational modification]
208435001318	intermolecular recognition site; other site
208435001319	dimerization interface [polypeptide binding]; other site
208435001320	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
208435001321	DNA binding site [nucleotide binding]
208435001322	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
208435001323	HAMP domain; Region: HAMP; pfam00672
208435001324	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
208435001325	dimer interface [polypeptide binding]; other site
208435001326	phosphorylation site [posttranslational modification]
208435001327	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
208435001328	ATP binding site [chemical binding]; other site
208435001329	Mg2+ binding site [ion binding]; other site
208435001330	G-X-G motif; other site
208435001331	Protein of unknown function (DUF975); Region: DUF975; pfam06161
208435001332	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
208435001333	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
208435001334	Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357
208435001335	CHY zinc finger; Region: zf-CHY; pfam05495
208435001336	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
208435001337	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
208435001338	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
208435001339	nucleoside/Zn binding site; other site
208435001340	dimer interface [polypeptide binding]; other site
208435001341	catalytic motif [active]
208435001342	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
208435001343	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
208435001344	active site
208435001345	dimer interface [polypeptide binding]; other site
208435001346	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
208435001347	dimer interface [polypeptide binding]; other site
208435001348	active site
208435001349	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
208435001350	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
208435001351	Rhomboid family; Region: Rhomboid; pfam01694
208435001352	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
208435001353	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
208435001354	ligand binding site [chemical binding]; other site
208435001355	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
208435001356	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
208435001357	active site
208435001358	tetramer interface; other site
208435001359	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
208435001360	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
208435001361	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
208435001362	ribonuclease P; Reviewed; Region: rnpA; PRK00499
208435001363	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
208435001364	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
208435001365	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
208435001366	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
208435001367	G-X-X-G motif; other site
208435001368	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
208435001369	RxxxH motif; other site
208435001370	hypothetical protein; Provisional; Region: PRK13662
208435001371	recombination regulator RecX; Provisional; Region: recX; PRK14135
208435001372	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
208435001373	TRAM domain; Region: TRAM; pfam01938
208435001374	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
208435001375	S-adenosylmethionine binding site [chemical binding]; other site
208435001376	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
208435001377	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
208435001378	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
208435001379	Coenzyme A binding pocket [chemical binding]; other site
208435001380	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
208435001381	putative active site [active]
208435001382	catalytic triad [active]
208435001383	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
208435001384	PA/protease domain interface [polypeptide binding]; other site
208435001385	putative integrin binding motif; other site
208435001386	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
208435001387	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
208435001388	C-terminal domain of CHU protein family; Region: CHU_C; cl17875
208435001389	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
208435001390	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
208435001391	Probable Catalytic site; other site
208435001392	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
208435001393	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
208435001394	dimer interface [polypeptide binding]; other site
208435001395	putative radical transfer pathway; other site
208435001396	diiron center [ion binding]; other site
208435001397	tyrosyl radical; other site
208435001398	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
208435001399	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07187
208435001400	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
208435001401	Class I ribonucleotide reductase; Region: RNR_I; cd01679
208435001402	active site
208435001403	dimer interface [polypeptide binding]; other site
208435001404	catalytic residues [active]
208435001405	effector binding site; other site
208435001406	R2 peptide binding site; other site
208435001407	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
208435001408	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
208435001409	Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase [General function prediction only]; Region: COG3576
208435001410	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
208435001411	Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078
208435001412	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
208435001413	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
208435001414	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
208435001415	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
208435001416	DNA binding residues [nucleotide binding]
208435001417	putative dimer interface [polypeptide binding]; other site
208435001418	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
208435001419	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
208435001420	catalytic Zn binding site [ion binding]; other site
208435001421	NAD(P) binding site [chemical binding]; other site
208435001422	structural Zn binding site [ion binding]; other site
208435001423	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
208435001424	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
208435001425	active site
208435001426	catalytic tetrad [active]
208435001427	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
208435001428	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
208435001429	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
208435001430	YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094
208435001431	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
208435001432	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
208435001433	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
208435001434	Alpha C protein N terminal; Region: AlphaC_N; pfam08829
208435001435	Rib/alpha-like repeat; Region: Rib; cl07159
208435001436	Rib/alpha-like repeat; Region: Rib; cl07159
208435001437	Rib/alpha-like repeat; Region: Rib; cl07159
208435001438	Rib/alpha-like repeat; Region: Rib; cl07159
208435001439	Rib/alpha-like repeat; Region: Rib; cl07159
208435001440	Rib/alpha-like repeat; Region: Rib; cl07159
208435001441	Rib/alpha-like repeat; Region: Rib; cl07159
208435001442	Rib/alpha-like repeat; Region: Rib; cl07159
208435001443	Rib/alpha-like repeat; Region: Rib; cl07159
208435001444	Rib/alpha-like repeat; Region: Rib; cl07159
208435001445	Rib/alpha-like repeat; Region: Rib; cl07159
208435001446	Rib/alpha-like repeat; Region: Rib; cl07159
208435001447	Rib/alpha-like repeat; Region: Rib; cl07159
208435001448	Rib/alpha-like repeat; Region: Rib; cl07159
208435001449	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
208435001450	RelB antitoxin; Region: RelB; cl01171
208435001451	Domain of unknown function (DUF1912); Region: DUF1912; pfam08930
208435001452	hypothetical protein; Provisional; Region: PRK07758
208435001453	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
208435001454	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
208435001455	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
208435001456	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
208435001457	AAA domain; Region: AAA_18; pfam13238
208435001458	AAA domain; Region: AAA_17; pfam13207
208435001459	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
208435001460	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
208435001461	active site
208435001462	HIGH motif; other site
208435001463	nucleotide binding site [chemical binding]; other site
208435001464	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
208435001465	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
208435001466	active site
208435001467	KMSKS motif; other site
208435001468	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
208435001469	tRNA binding surface [nucleotide binding]; other site
208435001470	anticodon binding site; other site
208435001471	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
208435001472	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
208435001473	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
208435001474	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
208435001475	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
208435001476	Cl binding site [ion binding]; other site
208435001477	oligomer interface [polypeptide binding]; other site
208435001478	Transposase, Mutator family; Region: Transposase_mut; pfam00872
208435001479	MULE transposase domain; Region: MULE; pfam10551
208435001480	Transposase; Region: DDE_Tnp_ISL3; pfam01610
208435001481	Protein of unknown function (DUF419); Region: DUF419; pfam04237
208435001482	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
208435001483	dimer interface [polypeptide binding]; other site
208435001484	active site
208435001485	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
208435001486	catalytic residues [active]
208435001487	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
208435001488	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
208435001489	S-adenosylmethionine binding site [chemical binding]; other site
208435001490	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
208435001491	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
208435001492	active site
208435001493	(T/H)XGH motif; other site
208435001494	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
208435001495	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
208435001496	protein binding site [polypeptide binding]; other site
208435001497	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
208435001498	Protein of unknown function (DUF1027); Region: DUF1027; cl09961
208435001499	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
208435001500	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
208435001501	FeS/SAM binding site; other site
208435001502	VanZ like family; Region: VanZ; pfam04892
208435001503	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
208435001504	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
208435001505	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
208435001506	Walker A/P-loop; other site
208435001507	ATP binding site [chemical binding]; other site
208435001508	Q-loop/lid; other site
208435001509	ABC transporter signature motif; other site
208435001510	Walker B; other site
208435001511	D-loop; other site
208435001512	H-loop/switch region; other site
208435001513	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
208435001514	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
208435001515	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
208435001516	Walker A/P-loop; other site
208435001517	ATP binding site [chemical binding]; other site
208435001518	Q-loop/lid; other site
208435001519	ABC transporter signature motif; other site
208435001520	Walker B; other site
208435001521	D-loop; other site
208435001522	H-loop/switch region; other site
208435001523	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
208435001524	Glutamine amidotransferase class-I; Region: GATase; pfam00117
208435001525	glutamine binding [chemical binding]; other site
208435001526	catalytic triad [active]
208435001527	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
208435001528	biotin synthase; Region: bioB; TIGR00433
208435001529	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
208435001530	FeS/SAM binding site; other site
208435001531	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
208435001532	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
208435001533	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
208435001534	dimer interface [polypeptide binding]; other site
208435001535	active site
208435001536	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
208435001537	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
208435001538	active site
208435001539	CoA binding site [chemical binding]; other site
208435001540	AMP binding site [chemical binding]; other site
208435001541	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
208435001542	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
208435001543	minor groove reading motif; other site
208435001544	helix-hairpin-helix signature motif; other site
208435001545	substrate binding pocket [chemical binding]; other site
208435001546	active site
208435001547	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
208435001548	Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014
208435001549	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
208435001550	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
208435001551	nucleotide binding site [chemical binding]; other site
208435001552	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
208435001553	active site residue [active]
208435001554	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
208435001555	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
208435001556	G1 box; other site
208435001557	putative GEF interaction site [polypeptide binding]; other site
208435001558	GTP/Mg2+ binding site [chemical binding]; other site
208435001559	Switch I region; other site
208435001560	G2 box; other site
208435001561	G3 box; other site
208435001562	Switch II region; other site
208435001563	G4 box; other site
208435001564	G5 box; other site
208435001565	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
208435001566	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
208435001567	Protein of unknown function (DUF3165); Region: DUF3165; pfam11364
208435001568	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
208435001569	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
208435001570	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
208435001571	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
208435001572	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
208435001573	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
208435001574	homodimer interface [polypeptide binding]; other site
208435001575	active site
208435001576	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
208435001577	Cell division protein FtsQ; Region: FtsQ; pfam03799
208435001578	Cell division protein FtsA; Region: FtsA; smart00842
208435001579	cell division protein FtsA; Region: ftsA; TIGR01174
208435001580	Cell division protein FtsA; Region: FtsA; pfam14450
208435001581	Domain of unknown function (DUF3484); Region: DUF3484; pfam11983
208435001582	cell division protein FtsZ; Validated; Region: PRK09330
208435001583	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
208435001584	nucleotide binding site [chemical binding]; other site
208435001585	SulA interaction site; other site
208435001586	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
208435001587	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
208435001588	catalytic residue [active]
208435001589	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
208435001590	YGGT family; Region: YGGT; pfam02325
208435001591	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
208435001592	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
208435001593	RNA binding surface [nucleotide binding]; other site
208435001594	DivIVA protein; Region: DivIVA; pfam05103
208435001595	DivIVA domain; Region: DivI1A_domain; TIGR03544
208435001596	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
208435001597	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
208435001598	active site
208435001599	HIGH motif; other site
208435001600	nucleotide binding site [chemical binding]; other site
208435001601	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
208435001602	active site
208435001603	KMSKS motif; other site
208435001604	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
208435001605	tRNA binding surface [nucleotide binding]; other site
208435001606	anticodon binding site; other site
208435001607	Domain of unknown function (DUF1827); Region: DUF1827; pfam08860
208435001608	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
208435001609	nudix motif; other site
208435001610	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
208435001611	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
208435001612	Walker A motif; other site
208435001613	ATP binding site [chemical binding]; other site
208435001614	Walker B motif; other site
208435001615	arginine finger; other site
208435001616	UvrB/uvrC motif; Region: UVR; pfam02151
208435001617	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
208435001618	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
208435001619	Walker A motif; other site
208435001620	ATP binding site [chemical binding]; other site
208435001621	Walker B motif; other site
208435001622	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
208435001623	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703
208435001624	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
208435001625	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
208435001626	dimer interface [polypeptide binding]; other site
208435001627	conserved gate region; other site
208435001628	putative PBP binding loops; other site
208435001629	ABC-ATPase subunit interface; other site
208435001630	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
208435001631	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
208435001632	Walker A/P-loop; other site
208435001633	ATP binding site [chemical binding]; other site
208435001634	Q-loop/lid; other site
208435001635	ABC transporter signature motif; other site
208435001636	Walker B; other site
208435001637	D-loop; other site
208435001638	H-loop/switch region; other site
208435001639	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
208435001640	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
208435001641	active site
208435001642	substrate binding site [chemical binding]; other site
208435001643	metal binding site [ion binding]; metal-binding site
208435001644	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179
208435001645	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
208435001646	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
208435001647	homodimer interface [polypeptide binding]; other site
208435001648	NADP binding site [chemical binding]; other site
208435001649	substrate binding site [chemical binding]; other site
208435001650	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
208435001651	putative substrate binding site [chemical binding]; other site
208435001652	putative ATP binding site [chemical binding]; other site
208435001653	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
208435001654	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
208435001655	generic binding surface II; other site
208435001656	generic binding surface I; other site
208435001657	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
208435001658	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
208435001659	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
208435001660	substrate binding pocket [chemical binding]; other site
208435001661	chain length determination region; other site
208435001662	substrate-Mg2+ binding site; other site
208435001663	catalytic residues [active]
208435001664	aspartate-rich region 1; other site
208435001665	active site lid residues [active]
208435001666	aspartate-rich region 2; other site
208435001667	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
208435001668	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
208435001669	RNA binding surface [nucleotide binding]; other site
208435001670	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
208435001671	Arginine repressor [Transcription]; Region: ArgR; COG1438
208435001672	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
208435001673	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
208435001674	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
208435001675	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
208435001676	Walker A/P-loop; other site
208435001677	ATP binding site [chemical binding]; other site
208435001678	Q-loop/lid; other site
208435001679	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
208435001680	ABC transporter signature motif; other site
208435001681	Walker B; other site
208435001682	D-loop; other site
208435001683	H-loop/switch region; other site
208435001684	EDD domain protein, DegV family; Region: DegV; TIGR00762
208435001685	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
208435001686	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
208435001687	active site
208435001688	catalytic triad [active]
208435001689	oxyanion hole [active]
208435001690	Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911
208435001691	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
208435001692	IHF dimer interface [polypeptide binding]; other site
208435001693	IHF - DNA interface [nucleotide binding]; other site
208435001694	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
208435001695	Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741
208435001696	active site
208435001697	FMN binding site [chemical binding]; other site
208435001698	substrate binding site [chemical binding]; other site
208435001699	catalytic residues [active]
208435001700	homodimer interface [polypeptide binding]; other site
208435001701	FemAB family; Region: FemAB; pfam02388
208435001702	FemAB family; Region: FemAB; pfam02388
208435001703	FemAB family; Region: FemAB; pfam02388
208435001704	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
208435001705	sugar phosphate phosphatase; Provisional; Region: PRK10513
208435001706	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
208435001707	active site
208435001708	motif I; other site
208435001709	motif II; other site
208435001710	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
208435001711	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
208435001712	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
208435001713	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
208435001714	Zn2+ binding site [ion binding]; other site
208435001715	Mg2+ binding site [ion binding]; other site
208435001716	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
208435001717	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
208435001718	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
208435001719	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
208435001720	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
208435001721	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
208435001722	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
208435001723	putative phosphoesterase; Region: acc_ester; TIGR03729
208435001724	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
208435001725	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
208435001726	epoxyqueuosine reductase; Region: TIGR00276
208435001727	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
208435001728	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
208435001729	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
208435001730	Walker A/P-loop; other site
208435001731	ATP binding site [chemical binding]; other site
208435001732	Q-loop/lid; other site
208435001733	ABC transporter signature motif; other site
208435001734	Walker B; other site
208435001735	D-loop; other site
208435001736	H-loop/switch region; other site
208435001737	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
208435001738	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
208435001739	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
208435001740	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
208435001741	acetoin reductase; Validated; Region: PRK08643
208435001742	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
208435001743	NAD binding site [chemical binding]; other site
208435001744	homotetramer interface [polypeptide binding]; other site
208435001745	homodimer interface [polypeptide binding]; other site
208435001746	active site
208435001747	substrate binding site [chemical binding]; other site
208435001748	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246
208435001749	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
208435001750	active site
208435001751	catalytic site [active]
208435001752	substrate binding site [chemical binding]; other site
208435001753	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
208435001754	ATP binding site [chemical binding]; other site
208435001755	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
208435001756	aspartate aminotransferase; Provisional; Region: PRK05764
208435001757	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
208435001758	pyridoxal 5'-phosphate binding site [chemical binding]; other site
208435001759	homodimer interface [polypeptide binding]; other site
208435001760	catalytic residue [active]
208435001761	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
208435001762	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
208435001763	putative dimer interface [polypeptide binding]; other site
208435001764	putative anticodon binding site; other site
208435001765	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
208435001766	homodimer interface [polypeptide binding]; other site
208435001767	motif 1; other site
208435001768	motif 2; other site
208435001769	active site
208435001770	motif 3; other site
208435001771	NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653
208435001772	active site
208435001773	OsmC-like protein; Region: OsmC; cl00767
208435001774	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
208435001775	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
208435001776	Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044
208435001777	dimer interface [polypeptide binding]; other site
208435001778	phosphate binding site [ion binding]; other site
208435001779	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
208435001780	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
208435001781	Peptidase family C69; Region: Peptidase_C69; pfam03577
208435001782	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
208435001783	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
208435001784	metal binding site [ion binding]; metal-binding site
208435001785	YodA lipocalin-like domain; Region: YodA; pfam09223
208435001786	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
208435001787	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
208435001788	DHH family; Region: DHH; pfam01368
208435001789	DHHA1 domain; Region: DHHA1; pfam02272
208435001790	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
208435001791	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
208435001792	active site
208435001793	purine riboside binding site [chemical binding]; other site
208435001794	flavodoxin; Validated; Region: PRK07308
208435001795	hypothetical protein; Provisional; Region: PRK07248
208435001796	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
208435001797	ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682
208435001798	putative Cl- selectivity filter; other site
208435001799	putative pore gating glutamate residue; other site
208435001800	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
208435001801	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
208435001802	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
208435001803	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
208435001804	lysogenic prophage LambdaSa1 region; nonfunctional prophage
208435001805	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
208435001806	Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199
208435001807	Int/Topo IB signature motif; other site
208435001808	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
208435001809	metal binding triad [ion binding]; metal-binding site
208435001810	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
208435001811	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
208435001812	non-specific DNA binding site [nucleotide binding]; other site
208435001813	salt bridge; other site
208435001814	sequence-specific DNA binding site [nucleotide binding]; other site
208435001815	Predicted transcriptional regulator [Transcription]; Region: COG2932
208435001816	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
208435001817	Catalytic site [active]
208435001818	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
208435001819	Domain of unknown function (DUF4393); Region: DUF4393; pfam14337
208435001820	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
208435001821	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
208435001822	non-specific DNA binding site [nucleotide binding]; other site
208435001823	salt bridge; other site
208435001824	sequence-specific DNA binding site [nucleotide binding]; other site
208435001825	Phage anti-repressor protein [Transcription]; Region: COG3561
208435001826	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
208435001827	N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889
208435001828	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
208435001829	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
208435001830	ERF superfamily; Region: ERF; pfam04404
208435001831	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
208435001832	G4 box; other site
208435001833	G5 box; other site
208435001834	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
208435001835	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
208435001836	dimer interface [polypeptide binding]; other site
208435001837	ssDNA binding site [nucleotide binding]; other site
208435001838	tetramer (dimer of dimers) interface [polypeptide binding]; other site
208435001839	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
208435001840	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
208435001841	putative active site [active]
208435001842	putative NTP binding site [chemical binding]; other site
208435001843	putative nucleic acid binding site [nucleotide binding]; other site
208435001844	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
208435001845	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
208435001846	Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659
208435001847	YopX protein; Region: YopX; cl09859
208435001848	Protein of unknown function (DUF1642); Region: DUF1642; pfam07852
208435001849	Protein of unknown function (DUF1492); Region: DUF1492; pfam07374
208435001850	Life-span regulatory factor; Region: Ecl1; pfam12855
208435001851	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
208435001852	Phage Terminase; Region: Terminase_1; pfam03354
208435001853	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
208435001854	ATP binding site [chemical binding]; other site
208435001855	putative Mg++ binding site [ion binding]; other site
208435001856	Domain of unknown function (DUF4355); Region: DUF4355; pfam14265
208435001857	Phage capsid family; Region: Phage_capsid; pfam05065
208435001858	HeH/LEM domain; Region: HeH; pfam12949
208435001859	Phage protein Gp19/Gp15/Gp42; Region: Phage_Gp19; pfam09355
208435001860	Phage-related protein [Function unknown]; Region: COG5412
208435001861	Phage tail protein; Region: Sipho_tail; pfam05709
208435001862	Phage tail protein; Region: Sipho_tail; cl17486
208435001863	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
208435001864	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
208435001865	Siphovirus protein of unknown function (DUF859); Region: DUF859; pfam05895
208435001866	Protein of unknown function (DUF1366); Region: DUF1366; pfam07104
208435001867	Phage holin protein (Holin_LLH); Region: Holin_LLH; pfam09682
208435001868	Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382
208435001869	Abi-like protein; Region: Abi_2; pfam07751
208435001870	CsbD-like; Region: CsbD; cl17424
208435001871	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
208435001872	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
208435001873	Helix-turn-helix domain; Region: HTH_28; pfam13518
208435001874	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
208435001875	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
208435001876	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
208435001877	Walker A/P-loop; other site
208435001878	ATP binding site [chemical binding]; other site
208435001879	Q-loop/lid; other site
208435001880	ABC transporter signature motif; other site
208435001881	Walker B; other site
208435001882	D-loop; other site
208435001883	H-loop/switch region; other site
208435001884	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
208435001885	FtsX-like permease family; Region: FtsX; pfam02687
208435001886	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
208435001887	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
208435001888	active site
208435001889	phosphorylation site [posttranslational modification]
208435001890	intermolecular recognition site; other site
208435001891	dimerization interface [polypeptide binding]; other site
208435001892	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
208435001893	DNA binding site [nucleotide binding]
208435001894	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
208435001895	dimerization interface [polypeptide binding]; other site
208435001896	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
208435001897	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
208435001898	dimer interface [polypeptide binding]; other site
208435001899	phosphorylation site [posttranslational modification]
208435001900	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
208435001901	ATP binding site [chemical binding]; other site
208435001902	Mg2+ binding site [ion binding]; other site
208435001903	G-X-G motif; other site
208435001904	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
208435001905	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
208435001906	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
208435001907	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
208435001908	motif II; other site
208435001909	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
208435001910	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
208435001911	Mg2+ binding site [ion binding]; other site
208435001912	G-X-G motif; other site
208435001913	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
208435001914	anchoring element; other site
208435001915	dimer interface [polypeptide binding]; other site
208435001916	ATP binding site [chemical binding]; other site
208435001917	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
208435001918	active site
208435001919	putative metal-binding site [ion binding]; other site
208435001920	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
208435001921	septation ring formation regulator EzrA; Provisional; Region: PRK04778
208435001922	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
208435001923	phosphoserine phosphatase SerB; Region: serB; TIGR00338
208435001924	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
208435001925	motif II; other site
208435001926	NUDIX domain; Region: NUDIX; pfam00293
208435001927	nudix motif; other site
208435001928	Protein of unknown function (DUF1694); Region: DUF1694; pfam07997
208435001929	enolase; Provisional; Region: eno; PRK00077
208435001930	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
208435001931	dimer interface [polypeptide binding]; other site
208435001932	metal binding site [ion binding]; metal-binding site
208435001933	substrate binding pocket [chemical binding]; other site
208435001934	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
208435001935	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
208435001936	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
208435001937	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
208435001938	hinge; other site
208435001939	active site
208435001940	shikimate kinase; Reviewed; Region: aroK; PRK00131
208435001941	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
208435001942	ADP binding site [chemical binding]; other site
208435001943	magnesium binding site [ion binding]; other site
208435001944	putative shikimate binding site; other site
208435001945	Transcriptional regulator [Transcription]; Region: LytR; COG1316
208435001946	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
208435001947	TRAM domain; Region: TRAM; cl01282
208435001948	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
208435001949	S-adenosylmethionine binding site [chemical binding]; other site
208435001950	acid phosphatase/phosphotransferase; Provisional; Region: aphA; PRK11009
208435001951	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
208435001952	putative transposase OrfB; Reviewed; Region: PHA02517
208435001953	HTH-like domain; Region: HTH_21; pfam13276
208435001954	Integrase core domain; Region: rve; pfam00665
208435001955	Integrase core domain; Region: rve_3; cl15866
208435001956	Transposase; Region: HTH_Tnp_1; pfam01527
208435001957	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
208435001958	YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094
208435001959	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
208435001960	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
208435001961	Cna protein B-type domain; Region: Cna_B; pfam05738
208435001962	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
208435001963	active site
208435001964	catalytic site [active]
208435001965	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
208435001966	active site
208435001967	catalytic site [active]
208435001968	Cna protein B-type domain; Region: Cna_B; pfam05738
208435001969	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
208435001970	metal ion-dependent adhesion site (MIDAS); other site
208435001971	Cna protein B-type domain; Region: Cna_B; pfam05738
208435001972	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
208435001973	active site
208435001974	catalytic site [active]
208435001975	Cna protein B-type domain; Region: Cna_B; pfam05738
208435001976	Beta-lactamase; Region: Beta-lactamase; pfam00144
208435001977	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
208435001978	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
208435001979	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
208435001980	Walker A/P-loop; other site
208435001981	ATP binding site [chemical binding]; other site
208435001982	Q-loop/lid; other site
208435001983	ABC transporter signature motif; other site
208435001984	Walker B; other site
208435001985	D-loop; other site
208435001986	H-loop/switch region; other site
208435001987	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
208435001988	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
208435001989	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694
208435001990	Acyl transferase domain; Region: Acyl_transf_1; cl08282
208435001991	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
208435001992	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
208435001993	NAD(P) binding site [chemical binding]; other site
208435001994	active site
208435001995	Phosphopantetheine attachment site; Region: PP-binding; cl09936
208435001996	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
208435001997	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
208435001998	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
208435001999	Walker A/P-loop; other site
208435002000	ATP binding site [chemical binding]; other site
208435002001	Q-loop/lid; other site
208435002002	ABC transporter signature motif; other site
208435002003	Walker B; other site
208435002004	D-loop; other site
208435002005	H-loop/switch region; other site
208435002006	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
208435002007	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
208435002008	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
208435002009	3-oxoacyl-(acyl carrier protein) synthase II; Provisional; Region: PRK14691
208435002010	dimer interface [polypeptide binding]; other site
208435002011	active site
208435002012	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
208435002013	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
208435002014	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
208435002015	putative cross-wall-targeting lipoprotein signal; Region: strep_RK_lipo; TIGR03726
208435002016	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
208435002017	putative active site [active]
208435002018	catalytic triad [active]
208435002019	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
208435002020	catalytic residues [active]
208435002021	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
208435002022	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
208435002023	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
208435002024	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
208435002025	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
208435002026	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
208435002027	FtsX-like permease family; Region: FtsX; pfam02687
208435002028	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
208435002029	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
208435002030	Walker A/P-loop; other site
208435002031	ATP binding site [chemical binding]; other site
208435002032	Q-loop/lid; other site
208435002033	ABC transporter signature motif; other site
208435002034	Walker B; other site
208435002035	D-loop; other site
208435002036	H-loop/switch region; other site
208435002037	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
208435002038	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
208435002039	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
208435002040	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
208435002041	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
208435002042	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
208435002043	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
208435002044	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
208435002045	Walker A/P-loop; other site
208435002046	ATP binding site [chemical binding]; other site
208435002047	Q-loop/lid; other site
208435002048	ABC transporter signature motif; other site
208435002049	Walker B; other site
208435002050	D-loop; other site
208435002051	H-loop/switch region; other site
208435002052	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
208435002053	Transcriptional regulator [Transcription]; Region: LysR; COG0583
208435002054	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
208435002055	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
208435002056	dimerization interface [polypeptide binding]; other site
208435002057	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
208435002058	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
208435002059	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
208435002060	Transposase [DNA replication, recombination, and repair]; Region: COG5433
208435002061	D-lactate dehydrogenase; Validated; Region: PRK08605
208435002062	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
208435002063	homodimer interface [polypeptide binding]; other site
208435002064	ligand binding site [chemical binding]; other site
208435002065	NAD binding site [chemical binding]; other site
208435002066	catalytic site [active]
208435002067	MFS/sugar transport protein; Region: MFS_2; pfam13347
208435002068	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
208435002069	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
208435002070	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
208435002071	substrate binding site [chemical binding]; other site
208435002072	ATP binding site [chemical binding]; other site
208435002073	beta-D-glucuronidase; Provisional; Region: PRK10150
208435002074	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
208435002075	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
208435002076	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
208435002077	Transcriptional regulators [Transcription]; Region: FadR; COG2186
208435002078	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
208435002079	DNA-binding site [nucleotide binding]; DNA binding site
208435002080	FCD domain; Region: FCD; pfam07729
208435002081	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
208435002082	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
208435002083	active site
208435002084	intersubunit interface [polypeptide binding]; other site
208435002085	catalytic residue [active]
208435002086	Glucuronate isomerase; Region: UxaC; pfam02614
208435002087	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
208435002088	mannonate dehydratase; Provisional; Region: PRK03906
208435002089	mannonate dehydratase; Region: uxuA; TIGR00695
208435002090	D-mannonate oxidoreductase; Provisional; Region: PRK08277
208435002091	putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935
208435002092	putative NAD(P) binding site [chemical binding]; other site
208435002093	active site
208435002094	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
208435002095	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
208435002096	motif II; other site
208435002097	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
208435002098	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
208435002099	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
208435002100	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
208435002101	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
208435002102	active site
208435002103	catabolite control protein A; Region: ccpA; TIGR01481
208435002104	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
208435002105	DNA binding site [nucleotide binding]
208435002106	domain linker motif; other site
208435002107	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
208435002108	dimerization interface [polypeptide binding]; other site
208435002109	effector binding site; other site
208435002110	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
208435002111	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
208435002112	active site
208435002113	Na/Ca binding site [ion binding]; other site
208435002114	catalytic site [active]
208435002115	Domain of unknown function (DUF1939); Region: DUF1939; pfam09154
208435002116	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
208435002117	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
208435002118	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
208435002119	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
208435002120	putative ADP-binding pocket [chemical binding]; other site
208435002121	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
208435002122	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
208435002123	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
208435002124	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
208435002125	active site
208435002126	dimer interface [polypeptide binding]; other site
208435002127	motif 1; other site
208435002128	motif 2; other site
208435002129	motif 3; other site
208435002130	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
208435002131	anticodon binding site; other site
208435002132	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
208435002133	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
208435002134	active site
208435002135	phosphorylation site [posttranslational modification]
208435002136	intermolecular recognition site; other site
208435002137	dimerization interface [polypeptide binding]; other site
208435002138	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
208435002139	DNA binding site [nucleotide binding]
208435002140	Protein of unknown function (DUF3114); Region: DUF3114; pfam11311
208435002141	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
208435002142	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
208435002143	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
208435002144	dimer interface [polypeptide binding]; other site
208435002145	conserved gate region; other site
208435002146	putative PBP binding loops; other site
208435002147	ABC-ATPase subunit interface; other site
208435002148	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
208435002149	dimer interface [polypeptide binding]; other site
208435002150	conserved gate region; other site
208435002151	putative PBP binding loops; other site
208435002152	ABC-ATPase subunit interface; other site
208435002153	bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917
208435002154	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
208435002155	substrate binding pocket [chemical binding]; other site
208435002156	membrane-bound complex binding site; other site
208435002157	hinge residues; other site
208435002158	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
208435002159	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
208435002160	Walker A/P-loop; other site
208435002161	ATP binding site [chemical binding]; other site
208435002162	Q-loop/lid; other site
208435002163	ABC transporter signature motif; other site
208435002164	Walker B; other site
208435002165	D-loop; other site
208435002166	H-loop/switch region; other site
208435002167	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
208435002168	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
208435002169	active site
208435002170	phosphorylation site [posttranslational modification]
208435002171	intermolecular recognition site; other site
208435002172	dimerization interface [polypeptide binding]; other site
208435002173	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
208435002174	DNA binding site [nucleotide binding]
208435002175	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
208435002176	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
208435002177	putative active site [active]
208435002178	heme pocket [chemical binding]; other site
208435002179	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
208435002180	dimer interface [polypeptide binding]; other site
208435002181	phosphorylation site [posttranslational modification]
208435002182	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
208435002183	ATP binding site [chemical binding]; other site
208435002184	Mg2+ binding site [ion binding]; other site
208435002185	G-X-G motif; other site
208435002186	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
208435002187	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
208435002188	Protein of unknown function (DUF454); Region: DUF454; cl01063
208435002189	ribonuclease III; Reviewed; Region: rnc; PRK00102
208435002190	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
208435002191	dimerization interface [polypeptide binding]; other site
208435002192	active site
208435002193	metal binding site [ion binding]; metal-binding site
208435002194	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
208435002195	dsRNA binding site [nucleotide binding]; other site
208435002196	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
208435002197	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
208435002198	Walker A/P-loop; other site
208435002199	ATP binding site [chemical binding]; other site
208435002200	Q-loop/lid; other site
208435002201	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
208435002202	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
208435002203	ABC transporter signature motif; other site
208435002204	Walker B; other site
208435002205	D-loop; other site
208435002206	H-loop/switch region; other site
208435002207	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
208435002208	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
208435002209	active site
208435002210	motif I; other site
208435002211	motif II; other site
208435002212	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
208435002213	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
208435002214	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
208435002215	active site
208435002216	motif I; other site
208435002217	motif II; other site
208435002218	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
208435002219	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
208435002220	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
208435002221	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
208435002222	P loop; other site
208435002223	GTP binding site [chemical binding]; other site
208435002224	Predicted membrane protein [Function unknown]; Region: COG3689
208435002225	Predicted permeases [General function prediction only]; Region: COG0701
208435002226	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
208435002227	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
208435002228	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
208435002229	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
208435002230	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
208435002231	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
208435002232	RNA binding site [nucleotide binding]; other site
208435002233	hypothetical protein; Provisional; Region: PRK04351
208435002234	SprT homologues; Region: SprT; cl01182
208435002235	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
208435002236	HPr kinase/phosphorylase; Provisional; Region: PRK05428
208435002237	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
208435002238	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
208435002239	Hpr binding site; other site
208435002240	active site
208435002241	homohexamer subunit interaction site [polypeptide binding]; other site
208435002242	Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790
208435002243	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
208435002244	YtxH-like protein; Region: YtxH; pfam12732
208435002245	Protein of unknown function (DUF3270); Region: DUF3270; pfam11674
208435002246	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
208435002247	Peptidase family U32; Region: Peptidase_U32; pfam01136
208435002248	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
208435002249	Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435
208435002250	Peptidase family U32; Region: Peptidase_U32; pfam01136
208435002251	Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901
208435002252	manganese transport protein MntH; Reviewed; Region: PRK00701
208435002253	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
208435002254	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
208435002255	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
208435002256	catalytic motif [active]
208435002257	Zn binding site [ion binding]; other site
208435002258	RibD C-terminal domain; Region: RibD_C; cl17279
208435002259	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
208435002260	Lumazine binding domain; Region: Lum_binding; pfam00677
208435002261	Lumazine binding domain; Region: Lum_binding; pfam00677
208435002262	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
208435002263	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
208435002264	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
208435002265	dimerization interface [polypeptide binding]; other site
208435002266	active site
208435002267	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
208435002268	homopentamer interface [polypeptide binding]; other site
208435002269	active site
208435002270	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
208435002271	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
208435002272	dimer interface [polypeptide binding]; other site
208435002273	putative anticodon binding site; other site
208435002274	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
208435002275	motif 1; other site
208435002276	active site
208435002277	motif 2; other site
208435002278	motif 3; other site
208435002279	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
208435002280	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
208435002281	motif II; other site
208435002282	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
208435002283	catalytic core [active]
208435002284	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
208435002285	putative deacylase active site [active]
208435002286	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
208435002287	NADH(P)-binding; Region: NAD_binding_10; pfam13460
208435002288	NAD(P) binding site [chemical binding]; other site
208435002289	active site
208435002290	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
208435002291	PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis.  PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b.  Both domains are required for...; Region: GH25_PlyB-like; cd06523
208435002292	active site
208435002293	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
208435002294	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
208435002295	oligoendopeptidase F; Region: pepF; TIGR00181
208435002296	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
208435002297	Zn binding site [ion binding]; other site
208435002298	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
208435002299	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
208435002300	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
208435002301	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
208435002302	Transposase [DNA replication, recombination, and repair]; Region: COG5433
208435002303	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
208435002304	elongation factor Tu; Reviewed; Region: PRK00049
208435002305	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
208435002306	G1 box; other site
208435002307	GEF interaction site [polypeptide binding]; other site
208435002308	GTP/Mg2+ binding site [chemical binding]; other site
208435002309	Switch I region; other site
208435002310	G2 box; other site
208435002311	G3 box; other site
208435002312	Switch II region; other site
208435002313	G4 box; other site
208435002314	G5 box; other site
208435002315	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
208435002316	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
208435002317	Antibiotic Binding Site [chemical binding]; other site
208435002318	triosephosphate isomerase; Provisional; Region: PRK14567
208435002319	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
208435002320	substrate binding site [chemical binding]; other site
208435002321	dimer interface [polypeptide binding]; other site
208435002322	catalytic triad [active]
208435002323	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
208435002324	catalytic core [active]
208435002325	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
208435002326	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
208435002327	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
208435002328	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
208435002329	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
208435002330	recombination protein RecR; Reviewed; Region: recR; PRK00076
208435002331	RecR protein; Region: RecR; pfam02132
208435002332	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
208435002333	putative active site [active]
208435002334	putative metal-binding site [ion binding]; other site
208435002335	tetramer interface [polypeptide binding]; other site
208435002336	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
208435002337	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
208435002338	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
208435002339	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
208435002340	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
208435002341	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
208435002342	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
208435002343	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
208435002344	putative substrate translocation pore; other site
208435002345	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529
208435002346	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
208435002347	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
208435002348	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
208435002349	G1 box; other site
208435002350	putative GEF interaction site [polypeptide binding]; other site
208435002351	GTP/Mg2+ binding site [chemical binding]; other site
208435002352	Switch I region; other site
208435002353	G2 box; other site
208435002354	G3 box; other site
208435002355	Switch II region; other site
208435002356	G4 box; other site
208435002357	G5 box; other site
208435002358	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
208435002359	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
208435002360	pentamer interface [polypeptide binding]; other site
208435002361	dodecaamer interface [polypeptide binding]; other site
208435002362	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
208435002363	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
208435002364	Walker A/P-loop; other site
208435002365	ATP binding site [chemical binding]; other site
208435002366	Q-loop/lid; other site
208435002367	ABC transporter signature motif; other site
208435002368	Walker B; other site
208435002369	D-loop; other site
208435002370	H-loop/switch region; other site
208435002371	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
208435002372	dimer interface [polypeptide binding]; other site
208435002373	conserved gate region; other site
208435002374	putative PBP binding loops; other site
208435002375	ABC-ATPase subunit interface; other site
208435002376	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
208435002377	NLPA lipoprotein; Region: Lipoprotein_9; cl17547
208435002378	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
208435002379	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
208435002380	ATP binding site [chemical binding]; other site
208435002381	Mg++ binding site [ion binding]; other site
208435002382	motif III; other site
208435002383	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
208435002384	nucleotide binding region [chemical binding]; other site
208435002385	ATP-binding site [chemical binding]; other site
208435002386	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
208435002387	GIY-YIG motif/motif A; other site
208435002388	putative active site [active]
208435002389	putative metal binding site [ion binding]; other site
208435002390	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
208435002391	Methyltransferase domain; Region: Methyltransf_26; pfam13659
208435002392	S-adenosylmethionine binding site [chemical binding]; other site
208435002393	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
208435002394	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
208435002395	putative acyl-acceptor binding pocket; other site
208435002396	SLBB domain; Region: SLBB; pfam10531
208435002397	comEA protein; Region: comE; TIGR01259
208435002398	Fingers domain of DNA polymerase lambda; Region: DNA_pol_lambd_f; pfam10391
208435002399	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
208435002400	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
208435002401	Competence protein; Region: Competence; pfam03772
208435002402	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
208435002403	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
208435002404	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
208435002405	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
208435002406	active site
208435002407	motif I; other site
208435002408	motif II; other site
208435002409	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
208435002410	Transcriptional regulators [Transcription]; Region: PurR; COG1609
208435002411	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
208435002412	DNA binding site [nucleotide binding]
208435002413	domain linker motif; other site
208435002414	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
208435002415	putative ligand binding site [chemical binding]; other site
208435002416	putative dimerization interface [polypeptide binding]; other site
208435002417	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
208435002418	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
208435002419	Methyltransferase domain; Region: Methyltransf_23; pfam13489
208435002420	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
208435002421	S-adenosylmethionine binding site [chemical binding]; other site
208435002422	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
208435002423	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
208435002424	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
208435002425	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
208435002426	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
208435002427	transcriptional antiterminator BglG; Provisional; Region: PRK09772
208435002428	CAT RNA binding domain; Region: CAT_RBD; pfam03123
208435002429	PRD domain; Region: PRD; pfam00874
208435002430	PRD domain; Region: PRD; pfam00874
208435002431	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
208435002432	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
208435002433	active site turn [active]
208435002434	phosphorylation site [posttranslational modification]
208435002435	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
208435002436	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
208435002437	HPr interaction site; other site
208435002438	glycerol kinase (GK) interaction site [polypeptide binding]; other site
208435002439	active site
208435002440	phosphorylation site [posttranslational modification]
208435002441	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
208435002442	beta-galactosidase; Region: BGL; TIGR03356
208435002443	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
208435002444	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
208435002445	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
208435002446	glycerate kinase; Region: TIGR00045
208435002447	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
208435002448	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
208435002449	Transcriptional regulators [Transcription]; Region: MarR; COG1846
208435002450	MarR family; Region: MarR; pfam01047
208435002451	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
208435002452	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
208435002453	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
208435002454	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
208435002455	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
208435002456	active site
208435002457	trimer interface [polypeptide binding]; other site
208435002458	allosteric site; other site
208435002459	active site lid [active]
208435002460	hexamer (dimer of trimers) interface [polypeptide binding]; other site
208435002461	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
208435002462	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
208435002463	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
208435002464	putative dimer interface [polypeptide binding]; other site
208435002465	N-terminal domain interface [polypeptide binding]; other site
208435002466	putative substrate binding pocket (H-site) [chemical binding]; other site
208435002467	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
208435002468	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
208435002469	RNA binding surface [nucleotide binding]; other site
208435002470	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
208435002471	active site
208435002472	uracil binding [chemical binding]; other site
208435002473	Major Facilitator Superfamily; Region: MFS_1; pfam07690
208435002474	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
208435002475	putative substrate translocation pore; other site
208435002476	Competence protein CoiA-like family; Region: CoiA; pfam06054
208435002477	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
208435002478	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
208435002479	active site
208435002480	Zn binding site [ion binding]; other site
208435002481	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
208435002482	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
208435002483	motif II; other site
208435002484	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
208435002485	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
208435002486	S-adenosylmethionine binding site [chemical binding]; other site
208435002487	foldase protein PrsA; Reviewed; Region: prsA; PRK01326
208435002488	Tubby C 2; Region: Tub_2; cl02043
208435002489	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
208435002490	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
208435002491	motif 1; other site
208435002492	active site
208435002493	motif 2; other site
208435002494	motif 3; other site
208435002495	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
208435002496	DHHA1 domain; Region: DHHA1; pfam02272
208435002497	Protein of unknown function (DUF554); Region: DUF554; pfam04474
208435002498	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
208435002499	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
208435002500	Ligand binding site; other site
208435002501	metal-binding site
208435002502	Pleckstrin homology-like domain; Region: PH-like; cl17171
208435002503	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
208435002504	non-specific DNA binding site [nucleotide binding]; other site
208435002505	salt bridge; other site
208435002506	sequence-specific DNA binding site [nucleotide binding]; other site
208435002507	Protein of unknown function (DUF3169); Region: DUF3169; pfam11368
208435002508	putative proton-coupled thiamine transporter YuaJ; Region: thia_yuaJ; TIGR02357
208435002509	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
208435002510	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
208435002511	dimer interface [polypeptide binding]; other site
208435002512	putative radical transfer pathway; other site
208435002513	diiron center [ion binding]; other site
208435002514	tyrosyl radical; other site
208435002515	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306
208435002516	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
208435002517	Class I ribonucleotide reductase; Region: RNR_I; cd01679
208435002518	active site
208435002519	dimer interface [polypeptide binding]; other site
208435002520	catalytic residues [active]
208435002521	effector binding site; other site
208435002522	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
208435002523	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
208435002524	catalytic residues [active]
208435002525	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
208435002526	dimerization domain swap beta strand [polypeptide binding]; other site
208435002527	regulatory protein interface [polypeptide binding]; other site
208435002528	active site
208435002529	regulatory phosphorylation site [posttranslational modification]; other site
208435002530	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
208435002531	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
208435002532	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
208435002533	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
208435002534	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
208435002535	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412
208435002536	tetrameric interface [polypeptide binding]; other site
208435002537	activator binding site; other site
208435002538	NADP binding site [chemical binding]; other site
208435002539	substrate binding site [chemical binding]; other site
208435002540	catalytic residues [active]
208435002541	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
208435002542	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
208435002543	DEAD-like helicases superfamily; Region: DEXDc; smart00487
208435002544	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
208435002545	ATP binding site [chemical binding]; other site
208435002546	putative Mg++ binding site [ion binding]; other site
208435002547	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
208435002548	nucleotide binding region [chemical binding]; other site
208435002549	ATP-binding site [chemical binding]; other site
208435002550	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
208435002551	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
208435002552	Sugar specificity; other site
208435002553	Pyrimidine base specificity; other site
208435002554	ATP-binding site [chemical binding]; other site
208435002555	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
208435002556	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
208435002557	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
208435002558	Walker A motif; other site
208435002559	ATP binding site [chemical binding]; other site
208435002560	DNA polymerase III subunit delta'; Validated; Region: PRK08485
208435002561	Walker B motif; other site
208435002562	arginine finger; other site
208435002563	Protein of unknown function (DUF3272); Region: DUF3272; pfam11676
208435002564	Biotin operon repressor [Transcription]; Region: BirA; COG1654
208435002565	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
208435002566	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
208435002567	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
208435002568	S-adenosylmethionine synthetase; Validated; Region: PRK05250
208435002569	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
208435002570	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
208435002571	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
208435002572	Staphylococcus aureus coagulase; Region: Coagulase; pfam08764
208435002573	Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512
208435002574	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819
208435002575	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
208435002576	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
208435002577	Walker A/P-loop; other site
208435002578	ATP binding site [chemical binding]; other site
208435002579	Q-loop/lid; other site
208435002580	ABC transporter signature motif; other site
208435002581	Walker B; other site
208435002582	D-loop; other site
208435002583	H-loop/switch region; other site
208435002584	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
208435002585	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
208435002586	Walker A/P-loop; other site
208435002587	ATP binding site [chemical binding]; other site
208435002588	Q-loop/lid; other site
208435002589	ABC transporter signature motif; other site
208435002590	Walker B; other site
208435002591	D-loop; other site
208435002592	H-loop/switch region; other site
208435002593	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
208435002594	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
208435002595	substrate binding site [chemical binding]; other site
208435002596	dimer interface [polypeptide binding]; other site
208435002597	ATP binding site [chemical binding]; other site
208435002598	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
208435002599	substrate binding site [chemical binding]; other site
208435002600	multimerization interface [polypeptide binding]; other site
208435002601	ATP binding site [chemical binding]; other site
208435002602	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
208435002603	thiamine phosphate binding site [chemical binding]; other site
208435002604	active site
208435002605	pyrophosphate binding site [ion binding]; other site
208435002606	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
208435002607	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
208435002608	hinge; other site
208435002609	active site
208435002610	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
208435002611	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
208435002612	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
208435002613	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
208435002614	DNA-binding site [nucleotide binding]; DNA binding site
208435002615	DRTGG domain; Region: DRTGG; pfam07085
208435002616	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
208435002617	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
208435002618	active site 2 [active]
208435002619	active site 1 [active]
208435002620	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
208435002621	active site
208435002622	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
208435002623	GtrA-like protein; Region: GtrA; pfam04138
208435002624	Predicted membrane protein [Function unknown]; Region: COG2246
208435002625	Predicted membrane protein [Function unknown]; Region: COG4708
208435002626	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
208435002627	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
208435002628	nucleotide binding pocket [chemical binding]; other site
208435002629	K-X-D-G motif; other site
208435002630	catalytic site [active]
208435002631	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
208435002632	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
208435002633	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
208435002634	Dimer interface [polypeptide binding]; other site
208435002635	BRCT sequence motif; other site
208435002636	putative lipid kinase; Reviewed; Region: PRK13055
208435002637	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
208435002638	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465
208435002639	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
208435002640	carbohydrate binding site [chemical binding]; other site
208435002641	pullulanase, type I; Region: pulA_typeI; TIGR02104
208435002642	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
208435002643	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
208435002644	Ca binding site [ion binding]; other site
208435002645	active site
208435002646	catalytic site [active]
208435002647	glycogen branching enzyme; Provisional; Region: PRK12313
208435002648	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
208435002649	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
208435002650	active site
208435002651	catalytic site [active]
208435002652	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
208435002653	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
208435002654	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
208435002655	ligand binding site; other site
208435002656	oligomer interface; other site
208435002657	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
208435002658	dimer interface [polypeptide binding]; other site
208435002659	N-terminal domain interface [polypeptide binding]; other site
208435002660	sulfate 1 binding site; other site
208435002661	glycogen synthase; Provisional; Region: glgA; PRK00654
208435002662	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
208435002663	ADP-binding pocket [chemical binding]; other site
208435002664	homodimer interface [polypeptide binding]; other site
208435002665	F0F1 ATP synthase subunit C; Provisional; Region: PRK13467
208435002666	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
208435002667	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
208435002668	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
208435002669	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
208435002670	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
208435002671	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
208435002672	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
208435002673	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
208435002674	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
208435002675	beta subunit interaction interface [polypeptide binding]; other site
208435002676	Walker A motif; other site
208435002677	ATP binding site [chemical binding]; other site
208435002678	Walker B motif; other site
208435002679	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
208435002680	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
208435002681	core domain interface [polypeptide binding]; other site
208435002682	delta subunit interface [polypeptide binding]; other site
208435002683	epsilon subunit interface [polypeptide binding]; other site
208435002684	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
208435002685	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
208435002686	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
208435002687	alpha subunit interaction interface [polypeptide binding]; other site
208435002688	Walker A motif; other site
208435002689	ATP binding site [chemical binding]; other site
208435002690	Walker B motif; other site
208435002691	inhibitor binding site; inhibition site
208435002692	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
208435002693	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
208435002694	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
208435002695	gamma subunit interface [polypeptide binding]; other site
208435002696	epsilon subunit interface [polypeptide binding]; other site
208435002697	LBP interface [polypeptide binding]; other site
208435002698	conserved hypothetical integral membrane protein; Region: int_mem_ywzB; TIGR02327
208435002699	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
208435002700	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
208435002701	hinge; other site
208435002702	active site
208435002703	DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772
208435002704	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223
208435002705	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
208435002706	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
208435002707	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
208435002708	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
208435002709	dimer interface [polypeptide binding]; other site
208435002710	motif 1; other site
208435002711	active site
208435002712	motif 2; other site
208435002713	motif 3; other site
208435002714	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
208435002715	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
208435002716	Coenzyme A binding pocket [chemical binding]; other site
208435002717	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
208435002718	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
208435002719	putative tRNA-binding site [nucleotide binding]; other site
208435002720	B3/4 domain; Region: B3_4; pfam03483
208435002721	tRNA synthetase B5 domain; Region: B5; smart00874
208435002722	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
208435002723	dimer interface [polypeptide binding]; other site
208435002724	motif 1; other site
208435002725	motif 3; other site
208435002726	motif 2; other site
208435002727	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
208435002728	Predicted metalloprotease [General function prediction only]; Region: COG2321
208435002729	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
208435002730	ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774
208435002731	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
208435002732	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
208435002733	Part of AAA domain; Region: AAA_19; pfam13245
208435002734	Family description; Region: UvrD_C_2; pfam13538
208435002735	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
208435002736	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
208435002737	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
208435002738	Cl binding site [ion binding]; other site
208435002739	oligomer interface [polypeptide binding]; other site
208435002740	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
208435002741	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
208435002742	trmE is a tRNA modification GTPase; Region: trmE; cd04164
208435002743	G1 box; other site
208435002744	GTP/Mg2+ binding site [chemical binding]; other site
208435002745	Switch I region; other site
208435002746	G2 box; other site
208435002747	Switch II region; other site
208435002748	G3 box; other site
208435002749	G4 box; other site
208435002750	G5 box; other site
208435002751	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
208435002752	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
208435002753	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
208435002754	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
208435002755	ABC transporter; Region: ABC_tran_2; pfam12848
208435002756	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
208435002757	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
208435002758	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
208435002759	tetramer interface [polypeptide binding]; other site
208435002760	TPP-binding site [chemical binding]; other site
208435002761	heterodimer interface [polypeptide binding]; other site
208435002762	phosphorylation loop region [posttranslational modification]
208435002763	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
208435002764	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
208435002765	alpha subunit interface [polypeptide binding]; other site
208435002766	TPP binding site [chemical binding]; other site
208435002767	heterodimer interface [polypeptide binding]; other site
208435002768	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
208435002769	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
208435002770	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
208435002771	E3 interaction surface; other site
208435002772	lipoyl attachment site [posttranslational modification]; other site
208435002773	e3 binding domain; Region: E3_binding; pfam02817
208435002774	e3 binding domain; Region: E3_binding; pfam02817
208435002775	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
208435002776	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
208435002777	E3 interaction surface; other site
208435002778	lipoyl attachment site [posttranslational modification]; other site
208435002779	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
208435002780	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
208435002781	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
208435002782	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
208435002783	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
208435002784	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
208435002785	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
208435002786	catalytic triad [active]
208435002787	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
208435002788	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
208435002789	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
208435002790	Uncharacterized conserved protein [Function unknown]; Region: COG1624
208435002791	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
208435002792	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
208435002793	YbbR-like protein; Region: YbbR; pfam07949
208435002794	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
208435002795	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
208435002796	active site
208435002797	substrate binding site [chemical binding]; other site
208435002798	metal binding site [ion binding]; metal-binding site
208435002799	Protein of unknown function (DUF1722); Region: DUF1722; cl01284
208435002800	conserved hypothetical protein; Region: TIGR02328
208435002801	Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013
208435002802	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
208435002803	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
208435002804	FeS/SAM binding site; other site
208435002805	HemN C-terminal domain; Region: HemN_C; pfam06969
208435002806	Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643
208435002807	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
208435002808	active site
208435002809	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
208435002810	active site 2 [active]
208435002811	active site 1 [active]
208435002812	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
208435002813	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
208435002814	active site
208435002815	motif I; other site
208435002816	motif II; other site
208435002817	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
208435002818	Protein of unknown function (DUF1461); Region: DUF1461; pfam07314
208435002819	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
208435002820	CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643
208435002821	CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865
208435002822	CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720
208435002823	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638
208435002824	CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd09758
208435002825	CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866
208435002826	tetramer interface [polypeptide binding]; other site
208435002827	putative DNA binding site [nucleotide binding]; other site
208435002828	Ca binding site [ion binding]; other site
208435002829	Ca binding site [ion binding]; other site
208435002830	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
208435002831	active site
208435002832	multimer interface [polypeptide binding]; other site
208435002833	GTP-binding protein LepA; Provisional; Region: PRK05433
208435002834	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
208435002835	G1 box; other site
208435002836	putative GEF interaction site [polypeptide binding]; other site
208435002837	GTP/Mg2+ binding site [chemical binding]; other site
208435002838	Switch I region; other site
208435002839	G2 box; other site
208435002840	G3 box; other site
208435002841	Switch II region; other site
208435002842	G4 box; other site
208435002843	G5 box; other site
208435002844	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
208435002845	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
208435002846	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
208435002847	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
208435002848	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
208435002849	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
208435002850	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
208435002851	Substrate binding site [chemical binding]; other site
208435002852	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
208435002853	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
208435002854	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
208435002855	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
208435002856	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
208435002857	Zn2+ binding site [ion binding]; other site
208435002858	Mg2+ binding site [ion binding]; other site
208435002859	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
208435002860	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
208435002861	Coenzyme A binding pocket [chemical binding]; other site
208435002862	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
208435002863	methionine sulfoxide reductase B; Provisional; Region: PRK00222
208435002864	SelR domain; Region: SelR; pfam01641
208435002865	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
208435002866	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
208435002867	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
208435002868	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
208435002869	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
208435002870	motif II; other site
208435002871	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
208435002872	Protein of unknown function (DUF2974); Region: DUF2974; pfam11187
208435002873	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
208435002874	trimer interface [polypeptide binding]; other site
208435002875	active site
208435002876	substrate binding site [chemical binding]; other site
208435002877	CoA binding site [chemical binding]; other site
208435002878	Uncharacterized conserved protein [Function unknown]; Region: COG0398
208435002879	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
208435002880	DNA binding domain of tn916 integrase; Region: Integrase_DNA; pfam02920
208435002881	Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199
208435002882	Int/Topo IB signature motif; other site
208435002883	Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035
208435002884	Helix-turn-helix domain; Region: HTH_16; pfam12645
208435002885	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
208435002886	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
208435002887	DNA binding residues [nucleotide binding]
208435002888	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
208435002889	non-specific DNA binding site [nucleotide binding]; other site
208435002890	salt bridge; other site
208435002891	sequence-specific DNA binding site [nucleotide binding]; other site
208435002892	Cysteine-rich KTR; Region: Cys_rich_KTR; pfam14205
208435002893	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
208435002894	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
208435002895	G1 box; other site
208435002896	putative GEF interaction site [polypeptide binding]; other site
208435002897	GTP/Mg2+ binding site [chemical binding]; other site
208435002898	Switch I region; other site
208435002899	G2 box; other site
208435002900	G3 box; other site
208435002901	Switch II region; other site
208435002902	G4 box; other site
208435002903	G5 box; other site
208435002904	Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690
208435002905	EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684
208435002906	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
208435002907	tetracycline resistance determinant leader peptide; Provisional; Region: PRK14751
208435002908	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
208435002909	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
208435002910	N-acetyl-D-glucosamine binding site [chemical binding]; other site
208435002911	catalytic residue [active]
208435002912	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
208435002913	NlpC/P60 family; Region: NLPC_P60; pfam00877
208435002914	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
208435002915	Haemolysin-III related; Region: HlyIII; cl03831
208435002916	TcpE family; Region: TcpE; pfam12648
208435002917	Antirestriction protein (ArdA); Region: ArdA; pfam07275
208435002918	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
208435002919	non-specific DNA binding site [nucleotide binding]; other site
208435002920	salt bridge; other site
208435002921	sequence-specific DNA binding site [nucleotide binding]; other site
208435002922	Replication initiation factor; Region: Rep_trans; pfam02486
208435002923	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
208435002924	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
208435002925	Walker A motif; other site
208435002926	ATP binding site [chemical binding]; other site
208435002927	Walker B motif; other site
208435002928	arginine finger; other site
208435002929	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
208435002930	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
208435002931	Predicted transcriptional regulators [Transcription]; Region: COG1725
208435002932	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
208435002933	DNA-binding site [nucleotide binding]; DNA binding site
208435002934	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279
208435002935	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
208435002936	active site
208435002937	PHP Thumb interface [polypeptide binding]; other site
208435002938	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
208435002939	generic binding surface II; other site
208435002940	generic binding surface I; other site
208435002941	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
208435002942	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
208435002943	active site
208435002944	ADP/pyrophosphate binding site [chemical binding]; other site
208435002945	dimerization interface [polypeptide binding]; other site
208435002946	allosteric effector site; other site
208435002947	fructose-1,6-bisphosphate binding site; other site
208435002948	pyruvate kinase; Provisional; Region: PRK05826
208435002949	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
208435002950	domain interfaces; other site
208435002951	active site
208435002952	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
208435002953	Peptidase S24-like; Region: Peptidase_S24; pfam00717
208435002954	Catalytic site [active]
208435002955	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
208435002956	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
208435002957	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
208435002958	glutaminase active site [active]
208435002959	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
208435002960	dimer interface [polypeptide binding]; other site
208435002961	active site
208435002962	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
208435002963	dimer interface [polypeptide binding]; other site
208435002964	active site
208435002965	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
208435002966	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
208435002967	Transposase [DNA replication, recombination, and repair]; Region: COG5433
208435002968	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
208435002969	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
208435002970	PhnA protein; Region: PhnA; pfam03831
208435002971	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
208435002972	dimer interface [polypeptide binding]; other site
208435002973	conserved gate region; other site
208435002974	putative PBP binding loops; other site
208435002975	ABC-ATPase subunit interface; other site
208435002976	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
208435002977	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
208435002978	Walker A/P-loop; other site
208435002979	ATP binding site [chemical binding]; other site
208435002980	Q-loop/lid; other site
208435002981	ABC transporter signature motif; other site
208435002982	Walker B; other site
208435002983	D-loop; other site
208435002984	H-loop/switch region; other site
208435002985	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
208435002986	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
208435002987	substrate binding pocket [chemical binding]; other site
208435002988	membrane-bound complex binding site; other site
208435002989	hinge residues; other site
208435002990	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
208435002991	pantothenate kinase; Provisional; Region: PRK05439
208435002992	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
208435002993	ATP-binding site [chemical binding]; other site
208435002994	CoA-binding site [chemical binding]; other site
208435002995	Mg2+-binding site [ion binding]; other site
208435002996	Methyltransferase domain; Region: Methyltransf_31; pfam13847
208435002997	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
208435002998	S-adenosylmethionine binding site [chemical binding]; other site
208435002999	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
208435003000	active site
208435003001	catalytic motif [active]
208435003002	Zn binding site [ion binding]; other site
208435003003	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
208435003004	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
208435003005	ligand binding site [chemical binding]; other site
208435003006	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
208435003007	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
208435003008	Walker A/P-loop; other site
208435003009	ATP binding site [chemical binding]; other site
208435003010	Q-loop/lid; other site
208435003011	ABC transporter signature motif; other site
208435003012	Walker B; other site
208435003013	D-loop; other site
208435003014	H-loop/switch region; other site
208435003015	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
208435003016	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
208435003017	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
208435003018	TM-ABC transporter signature motif; other site
208435003019	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
208435003020	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
208435003021	TM-ABC transporter signature motif; other site
208435003022	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
208435003023	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
208435003024	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
208435003025	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
208435003026	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
208435003027	tetramer (dimer of dimers) interface [polypeptide binding]; other site
208435003028	NAD binding site [chemical binding]; other site
208435003029	dimer interface [polypeptide binding]; other site
208435003030	substrate binding site [chemical binding]; other site
208435003031	DNA gyrase subunit A; Validated; Region: PRK05560
208435003032	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
208435003033	CAP-like domain; other site
208435003034	active site
208435003035	primary dimer interface [polypeptide binding]; other site
208435003036	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
208435003037	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
208435003038	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
208435003039	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
208435003040	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
208435003041	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
208435003042	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
208435003043	active site
208435003044	catalytic site [active]
208435003045	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
208435003046	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
208435003047	putative metal binding site [ion binding]; other site
208435003048	Predicted secreted protein [Function unknown]; Region: COG4086
208435003049	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
208435003050	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
208435003051	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
208435003052	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
208435003053	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
208435003054	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
208435003055	GMP synthase; Reviewed; Region: guaA; PRK00074
208435003056	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
208435003057	AMP/PPi binding site [chemical binding]; other site
208435003058	candidate oxyanion hole; other site
208435003059	catalytic triad [active]
208435003060	potential glutamine specificity residues [chemical binding]; other site
208435003061	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
208435003062	ATP Binding subdomain [chemical binding]; other site
208435003063	Dimerization subdomain; other site
208435003064	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
208435003065	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
208435003066	DNA-binding site [nucleotide binding]; DNA binding site
208435003067	UTRA domain; Region: UTRA; pfam07702
208435003068	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
208435003069	Glucose inhibited division protein A; Region: GIDA; pfam01134
208435003070	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
208435003071	Coenzyme A binding pocket [chemical binding]; other site
208435003072	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
208435003073	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
208435003074	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
208435003075	Active site serine [active]
208435003076	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
208435003077	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
208435003078	Walker A/P-loop; other site
208435003079	ATP binding site [chemical binding]; other site
208435003080	Q-loop/lid; other site
208435003081	ABC transporter signature motif; other site
208435003082	Walker B; other site
208435003083	D-loop; other site
208435003084	H-loop/switch region; other site
208435003085	FtsX-like permease family; Region: FtsX; pfam02687
208435003086	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
208435003087	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
208435003088	active site
208435003089	phosphorylation site [posttranslational modification]
208435003090	intermolecular recognition site; other site
208435003091	dimerization interface [polypeptide binding]; other site
208435003092	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
208435003093	DNA binding site [nucleotide binding]
208435003094	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
208435003095	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
208435003096	ATP binding site [chemical binding]; other site
208435003097	Mg2+ binding site [ion binding]; other site
208435003098	G-X-G motif; other site
208435003099	site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084
208435003100	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
208435003101	active site
208435003102	DNA binding site [nucleotide binding]
208435003103	Int/Topo IB signature motif; other site
208435003104	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
208435003105	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
208435003106	peptide binding site [polypeptide binding]; other site
208435003107	Protein of unknown function (DUF3307); Region: DUF3307; pfam11750
208435003108	signal recognition particle protein; Provisional; Region: PRK10867
208435003109	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
208435003110	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
208435003111	P loop; other site
208435003112	GTP binding site [chemical binding]; other site
208435003113	Signal peptide binding domain; Region: SRP_SPB; pfam02978
208435003114	putative DNA-binding protein; Validated; Region: PRK00118
208435003115	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
208435003116	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
208435003117	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
208435003118	dimer interface [polypeptide binding]; other site
208435003119	phosphorylation site [posttranslational modification]
208435003120	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
208435003121	ATP binding site [chemical binding]; other site
208435003122	Mg2+ binding site [ion binding]; other site
208435003123	G-X-G motif; other site
208435003124	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
208435003125	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
208435003126	active site
208435003127	phosphorylation site [posttranslational modification]
208435003128	intermolecular recognition site; other site
208435003129	dimerization interface [polypeptide binding]; other site
208435003130	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
208435003131	DNA binding site [nucleotide binding]
208435003132	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
208435003133	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
208435003134	Zn binding site [ion binding]; other site
208435003135	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
208435003136	PhoU domain; Region: PhoU; pfam01895
208435003137	PhoU domain; Region: PhoU; pfam01895
208435003138	phosphate transporter ATP-binding protein; Provisional; Region: PRK14239
208435003139	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
208435003140	Walker A/P-loop; other site
208435003141	ATP binding site [chemical binding]; other site
208435003142	Q-loop/lid; other site
208435003143	ABC transporter signature motif; other site
208435003144	Walker B; other site
208435003145	D-loop; other site
208435003146	H-loop/switch region; other site
208435003147	phosphate transporter ATP-binding protein; Provisional; Region: PRK14237
208435003148	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
208435003149	Walker A/P-loop; other site
208435003150	ATP binding site [chemical binding]; other site
208435003151	Q-loop/lid; other site
208435003152	ABC transporter signature motif; other site
208435003153	Walker B; other site
208435003154	D-loop; other site
208435003155	H-loop/switch region; other site
208435003156	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
208435003157	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
208435003158	dimer interface [polypeptide binding]; other site
208435003159	conserved gate region; other site
208435003160	putative PBP binding loops; other site
208435003161	ABC-ATPase subunit interface; other site
208435003162	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
208435003163	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
208435003164	dimer interface [polypeptide binding]; other site
208435003165	conserved gate region; other site
208435003166	putative PBP binding loops; other site
208435003167	ABC-ATPase subunit interface; other site
208435003168	PBP superfamily domain; Region: PBP_like_2; cl17296
208435003169	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
208435003170	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
208435003171	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
208435003172	S-adenosylmethionine binding site [chemical binding]; other site
208435003173	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
208435003174	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
208435003175	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
208435003176	active site
208435003177	hypothetical protein; Provisional; Region: PRK04387
208435003178	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
208435003179	ArsC family; Region: ArsC; pfam03960
208435003180	putative catalytic residues [active]
208435003181	thiol/disulfide switch; other site
208435003182	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
208435003183	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
208435003184	active site
208435003185	Riboflavin kinase; Region: Flavokinase; smart00904
208435003186	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484
208435003187	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
208435003188	RNA binding site [nucleotide binding]; other site
208435003189	active site
208435003190	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
208435003191	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
208435003192	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
208435003193	Coenzyme A binding pocket [chemical binding]; other site
208435003194	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
208435003195	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
208435003196	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
208435003197	CAAX protease self-immunity; Region: Abi; pfam02517
208435003198	FtsX-like permease family; Region: FtsX; pfam02687
208435003199	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
208435003200	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
208435003201	FtsX-like permease family; Region: FtsX; pfam02687
208435003202	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
208435003203	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
208435003204	Walker A/P-loop; other site
208435003205	ATP binding site [chemical binding]; other site
208435003206	Q-loop/lid; other site
208435003207	ABC transporter signature motif; other site
208435003208	Walker B; other site
208435003209	D-loop; other site
208435003210	H-loop/switch region; other site
208435003211	DNA topoisomerase I; Validated; Region: PRK05582
208435003212	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
208435003213	active site
208435003214	interdomain interaction site; other site
208435003215	putative metal-binding site [ion binding]; other site
208435003216	nucleotide binding site [chemical binding]; other site
208435003217	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
208435003218	domain I; other site
208435003219	DNA binding groove [nucleotide binding]
208435003220	phosphate binding site [ion binding]; other site
208435003221	domain II; other site
208435003222	domain III; other site
208435003223	nucleotide binding site [chemical binding]; other site
208435003224	catalytic site [active]
208435003225	domain IV; other site
208435003226	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
208435003227	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
208435003228	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
208435003229	DNA protecting protein DprA; Region: dprA; TIGR00732
208435003230	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
208435003231	putative ligand binding residues [chemical binding]; other site
208435003232	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
208435003233	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
208435003234	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
208435003235	Walker A/P-loop; other site
208435003236	ATP binding site [chemical binding]; other site
208435003237	Q-loop/lid; other site
208435003238	ABC transporter signature motif; other site
208435003239	Walker B; other site
208435003240	D-loop; other site
208435003241	H-loop/switch region; other site
208435003242	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
208435003243	ABC-ATPase subunit  interface; other site
208435003244	dimer interface [polypeptide binding]; other site
208435003245	putative PBP binding regions; other site
208435003246	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
208435003247	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
208435003248	ABC-ATPase subunit  interface; other site
208435003249	dimer interface [polypeptide binding]; other site
208435003250	putative PBP binding regions; other site
208435003251	maltose O-acetyltransferase; Provisional; Region: PRK10092
208435003252	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
208435003253	active site
208435003254	substrate binding site [chemical binding]; other site
208435003255	trimer interface [polypeptide binding]; other site
208435003256	CoA binding site [chemical binding]; other site
208435003257	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
208435003258	RNA/DNA hybrid binding site [nucleotide binding]; other site
208435003259	active site
208435003260	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
208435003261	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
208435003262	GTP/Mg2+ binding site [chemical binding]; other site
208435003263	G4 box; other site
208435003264	G5 box; other site
208435003265	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
208435003266	G1 box; other site
208435003267	G1 box; other site
208435003268	GTP/Mg2+ binding site [chemical binding]; other site
208435003269	Switch I region; other site
208435003270	G2 box; other site
208435003271	G2 box; other site
208435003272	G3 box; other site
208435003273	G3 box; other site
208435003274	Switch II region; other site
208435003275	Switch II region; other site
208435003276	G5 box; other site
208435003277	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
208435003278	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
208435003279	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
208435003280	Carbon starvation protein CstA; Region: CstA; pfam02554
208435003281	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
208435003282	two-component response regulator; Provisional; Region: PRK14084
208435003283	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
208435003284	active site
208435003285	phosphorylation site [posttranslational modification]
208435003286	intermolecular recognition site; other site
208435003287	dimerization interface [polypeptide binding]; other site
208435003288	LytTr DNA-binding domain; Region: LytTR; pfam04397
208435003289	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
208435003290	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
208435003291	GAF domain; Region: GAF_3; pfam13492
208435003292	Histidine kinase; Region: His_kinase; pfam06580
208435003293	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
208435003294	ATP binding site [chemical binding]; other site
208435003295	Mg2+ binding site [ion binding]; other site
208435003296	G-X-G motif; other site
208435003297	Domain of unknown function (DUF4176); Region: DUF4176; cl01867
208435003298	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
208435003299	Domain of unknown function (DUF4176); Region: DUF4176; pfam13780
208435003300	type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197
208435003301	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
208435003302	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
208435003303	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
208435003304	DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538
208435003305	type VII secretion protein EssB; Region: T7_EssB; TIGR03926
208435003306	WXG100 protein secretion system (Wss), protein YukC; Region: YukC; pfam10140
208435003307	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817
208435003308	type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927
208435003309	type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929
208435003310	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
208435003311	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
208435003312	Protein of unknown function (DUF2974); Region: DUF2974; pfam11187
208435003313	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
208435003314	nucleophilic elbow; other site
208435003315	catalytic triad; other site
208435003316	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
208435003317	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
208435003318	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
208435003319	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
208435003320	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
208435003321	ATP-grasp domain; Region: ATP-grasp_4; cl17255
208435003322	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
208435003323	IMP binding site; other site
208435003324	dimer interface [polypeptide binding]; other site
208435003325	interdomain contacts; other site
208435003326	partial ornithine binding site; other site
208435003327	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
208435003328	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
208435003329	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
208435003330	catalytic site [active]
208435003331	subunit interface [polypeptide binding]; other site
208435003332	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
208435003333	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
208435003334	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
208435003335	dihydroorotase; Validated; Region: pyrC; PRK09357
208435003336	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
208435003337	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
208435003338	active site
208435003339	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
208435003340	active site
208435003341	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
208435003342	active site
208435003343	dimer interface [polypeptide binding]; other site
208435003344	Uncharacterized conserved protein [Function unknown]; Region: COG2966
208435003345	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
208435003346	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
208435003347	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
208435003348	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
208435003349	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
208435003350	ABC transporter; Region: ABC_tran_2; pfam12848
208435003351	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
208435003352	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
208435003353	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
208435003354	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
208435003355	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
208435003356	Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154
208435003357	putative active site [active]
208435003358	catalytic site [active]
208435003359	Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160
208435003360	putative active site [active]
208435003361	catalytic site [active]
208435003362	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
208435003363	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
208435003364	Potassium binding sites [ion binding]; other site
208435003365	Cesium cation binding sites [ion binding]; other site
208435003366	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
208435003367	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
208435003368	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
208435003369	NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846
208435003370	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
208435003371	hypothetical protein; Provisional; Region: PRK04143
208435003372	ADP-ribose binding site [chemical binding]; other site
208435003373	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
208435003374	lipoyl attachment site [posttranslational modification]; other site
208435003375	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
208435003376	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
208435003377	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
208435003378	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
208435003379	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
208435003380	putative active site [active]
208435003381	putative FMN binding site [chemical binding]; other site
208435003382	putative substrate binding site [chemical binding]; other site
208435003383	putative catalytic residue [active]
208435003384	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
208435003385	phosphopantothenate--cysteine ligase; Validated; Region: PRK06732
208435003386	phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113
208435003387	Flavoprotein; Region: Flavoprotein; pfam02441
208435003388	Predicted membrane protein [Function unknown]; Region: COG4684
208435003389	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
208435003390	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
208435003391	active site
208435003392	substrate binding site [chemical binding]; other site
208435003393	metal binding site [ion binding]; metal-binding site
208435003394	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
208435003395	putative transposase OrfB; Reviewed; Region: PHA02517
208435003396	HTH-like domain; Region: HTH_21; pfam13276
208435003397	Integrase core domain; Region: rve; pfam00665
208435003398	Integrase core domain; Region: rve_2; pfam13333
208435003399	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
208435003400	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
208435003401	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
208435003402	Walker A/P-loop; other site
208435003403	ATP binding site [chemical binding]; other site
208435003404	Q-loop/lid; other site
208435003405	ABC transporter signature motif; other site
208435003406	Walker B; other site
208435003407	D-loop; other site
208435003408	H-loop/switch region; other site
208435003409	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
208435003410	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
208435003411	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
208435003412	Walker A/P-loop; other site
208435003413	ATP binding site [chemical binding]; other site
208435003414	Q-loop/lid; other site
208435003415	ABC transporter signature motif; other site
208435003416	Walker B; other site
208435003417	D-loop; other site
208435003418	H-loop/switch region; other site
208435003419	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
208435003420	N-acetyl-D-glucosamine binding site [chemical binding]; other site
208435003421	catalytic residue [active]
208435003422	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
208435003423	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
208435003424	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
208435003425	dimer interface [polypeptide binding]; other site
208435003426	active site
208435003427	glycine-pyridoxal phosphate binding site [chemical binding]; other site
208435003428	folate binding site [chemical binding]; other site
208435003429	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
208435003430	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
208435003431	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
208435003432	S-adenosylmethionine binding site [chemical binding]; other site
208435003433	peptide chain release factor 1; Validated; Region: prfA; PRK00591
208435003434	This domain is found in peptide chain release factors; Region: PCRF; smart00937
208435003435	RF-1 domain; Region: RF-1; pfam00472
208435003436	thymidine kinase; Provisional; Region: PRK04296
208435003437	4-oxalocrotonate tautomerase; Provisional; Region: PRK02289
208435003438	active site 1 [active]
208435003439	dimer interface [polypeptide binding]; other site
208435003440	hexamer interface [polypeptide binding]; other site
208435003441	active site 2 [active]
208435003442	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
208435003443	ApbE family; Region: ApbE; pfam02424
208435003444	Predicted flavoprotein [General function prediction only]; Region: COG0431
208435003445	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
208435003446	Predicted flavoprotein [General function prediction only]; Region: COG0431
208435003447	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
208435003448	PAS domain; Region: PAS_10; pfam13596
208435003449	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
208435003450	xanthine permease; Region: pbuX; TIGR03173
208435003451	Sulfate transporter family; Region: Sulfate_transp; pfam00916
208435003452	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
208435003453	active site
208435003454	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
208435003455	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
208435003456	active site
208435003457	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
208435003458	Major Facilitator Superfamily; Region: MFS_1; pfam07690
208435003459	putative substrate translocation pore; other site
208435003460	K+ potassium transporter; Region: K_trans; cl15781
208435003461	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
208435003462	NAD(P) binding site [chemical binding]; other site
208435003463	active site
208435003464	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
208435003465	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
208435003466	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
208435003467	active site
208435003468	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
208435003469	ATP-NAD kinase; Region: NAD_kinase; pfam01513
208435003470	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
208435003471	synthetase active site [active]
208435003472	NTP binding site [chemical binding]; other site
208435003473	metal binding site [ion binding]; metal-binding site
208435003474	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
208435003475	putative active site [active]
208435003476	putative metal binding residues [ion binding]; other site
208435003477	signature motif; other site
208435003478	putative triphosphate binding site [ion binding]; other site
208435003479	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458
208435003480	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
208435003481	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
208435003482	active site
208435003483	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
208435003484	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
208435003485	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
208435003486	catalytic residue [active]
208435003487	Putative amino acid metabolism; Region: DUF1831; pfam08866
208435003488	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
208435003489	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
208435003490	CoA binding domain; Region: CoA_binding; pfam02629
208435003491	hypothetical protein; Reviewed; Region: PRK00024
208435003492	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
208435003493	MPN+ (JAMM) motif; other site
208435003494	Zinc-binding site [ion binding]; other site
208435003495	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
208435003496	6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593
208435003497	beta-galactosidase; Region: BGL; TIGR03356
208435003498	NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841
208435003499	active site
208435003500	catalytic triad [active]
208435003501	oxyanion hole [active]
208435003502	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
208435003503	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
208435003504	active site
208435003505	motif I; other site
208435003506	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
208435003507	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
208435003508	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
208435003509	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
208435003510	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
208435003511	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
208435003512	Cl- selectivity filter; other site
208435003513	Cl- binding residues [ion binding]; other site
208435003514	pore gating glutamate residue; other site
208435003515	dimer interface [polypeptide binding]; other site
208435003516	H+/Cl- coupling transport residue; other site
208435003517	TrkA-C domain; Region: TrkA_C; pfam02080
208435003518	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
208435003519	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
208435003520	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
208435003521	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
208435003522	dimer interface [polypeptide binding]; other site
208435003523	conserved gate region; other site
208435003524	putative PBP binding loops; other site
208435003525	ABC-ATPase subunit interface; other site
208435003526	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
208435003527	dimer interface [polypeptide binding]; other site
208435003528	conserved gate region; other site
208435003529	putative PBP binding loops; other site
208435003530	ABC-ATPase subunit interface; other site
208435003531	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
208435003532	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
208435003533	Walker A/P-loop; other site
208435003534	ATP binding site [chemical binding]; other site
208435003535	Q-loop/lid; other site
208435003536	ABC transporter signature motif; other site
208435003537	Walker B; other site
208435003538	D-loop; other site
208435003539	H-loop/switch region; other site
208435003540	TOBE domain; Region: TOBE_2; pfam08402
208435003541	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
208435003542	FAD binding domain; Region: FAD_binding_4; pfam01565
208435003543	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
208435003544	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
208435003545	catalytic center binding site [active]
208435003546	ATP binding site [chemical binding]; other site
208435003547	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
208435003548	homooctamer interface [polypeptide binding]; other site
208435003549	active site
208435003550	dihydropteroate synthase; Region: DHPS; TIGR01496
208435003551	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
208435003552	substrate binding pocket [chemical binding]; other site
208435003553	dimer interface [polypeptide binding]; other site
208435003554	inhibitor binding site; inhibition site
208435003555	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
208435003556	homodecamer interface [polypeptide binding]; other site
208435003557	GTP cyclohydrolase I; Provisional; Region: PLN03044
208435003558	active site
208435003559	putative catalytic site residues [active]
208435003560	zinc binding site [ion binding]; other site
208435003561	GTP-CH-I/GFRP interaction surface; other site
208435003562	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
208435003563	SNF2 Helicase protein; Region: DUF3670; pfam12419
208435003564	Predicted permeases [General function prediction only]; Region: RarD; COG2962
208435003565	homoserine kinase; Provisional; Region: PRK01212
208435003566	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
208435003567	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
208435003568	homoserine dehydrogenase; Provisional; Region: PRK06349
208435003569	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
208435003570	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
208435003571	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
208435003572	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
208435003573	putative active site [active]
208435003574	putative metal binding site [ion binding]; other site
208435003575	BCCT family transporter; Region: BCCT; pfam02028
208435003576	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
208435003577	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
208435003578	NAD(P) binding site [chemical binding]; other site
208435003579	catalytic residues [active]
208435003580	Predicted membrane protein [Function unknown]; Region: COG2855
208435003581	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
208435003582	non-specific DNA binding site [nucleotide binding]; other site
208435003583	salt bridge; other site
208435003584	sequence-specific DNA binding site [nucleotide binding]; other site
208435003585	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
208435003586	dimer interface [polypeptide binding]; other site
208435003587	catalytic triad [active]
208435003588	peroxidatic and resolving cysteines [active]
208435003589	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
208435003590	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
208435003591	active site
208435003592	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
208435003593	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
208435003594	active site
208435003595	motif I; other site
208435003596	motif II; other site
208435003597	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
208435003598	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
208435003599	DNA-binding site [nucleotide binding]; DNA binding site
208435003600	TrkA-C domain; Region: TrkA_C; pfam02080
208435003601	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
208435003602	CsbD-like; Region: CsbD; pfam05532
208435003603	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
208435003604	Small integral membrane protein [Function unknown]; Region: COG5547
208435003605	Predicted membrane protein [Function unknown]; Region: COG2261
208435003606	Predicted membrane protein [Function unknown]; Region: COG2261
208435003607	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
208435003608	Part of AAA domain; Region: AAA_19; pfam13245
208435003609	AAA domain; Region: AAA_12; pfam13087
208435003610	Family description; Region: UvrD_C_2; pfam13538
208435003611	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
208435003612	CoenzymeA binding site [chemical binding]; other site
208435003613	subunit interaction site [polypeptide binding]; other site
208435003614	PHB binding site; other site
208435003615	uracil transporter; Provisional; Region: PRK10720
208435003616	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
208435003617	amino acid carrier protein; Region: agcS; TIGR00835
208435003618	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
208435003619	Cation efflux family; Region: Cation_efflux; pfam01545
208435003620	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
208435003621	LrgB-like family; Region: LrgB; pfam04172
208435003622	Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978
208435003623	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
208435003624	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
208435003625	RNA binding site [nucleotide binding]; other site
208435003626	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
208435003627	RNA binding site [nucleotide binding]; other site
208435003628	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
208435003629	RNA binding site [nucleotide binding]; other site
208435003630	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
208435003631	RNA binding site [nucleotide binding]; other site
208435003632	Protein of unknown function (DUF2969); Region: DUF2969; pfam11184
208435003633	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
208435003634	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
208435003635	homodimer interface [polypeptide binding]; other site
208435003636	substrate-cofactor binding pocket; other site
208435003637	catalytic residue [active]
208435003638	DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061
208435003639	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
208435003640	CAP-like domain; other site
208435003641	active site
208435003642	primary dimer interface [polypeptide binding]; other site
208435003643	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
208435003644	DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058
208435003645	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
208435003646	Mg2+ binding site [ion binding]; other site
208435003647	G-X-G motif; other site
208435003648	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
208435003649	anchoring element; other site
208435003650	dimer interface [polypeptide binding]; other site
208435003651	ATP binding site [chemical binding]; other site
208435003652	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
208435003653	active site
208435003654	putative metal-binding site [ion binding]; other site
208435003655	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
208435003656	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
208435003657	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
208435003658	ligand binding site [chemical binding]; other site
208435003659	active site
208435003660	UGI interface [polypeptide binding]; other site
208435003661	catalytic site [active]
208435003662	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
208435003663	ligand binding site; other site
208435003664	tetramer interface; other site
208435003665	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
208435003666	active site
208435003667	catalytic triad [active]
208435003668	oxyanion hole [active]
208435003669	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
208435003670	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
208435003671	putative trimer interface [polypeptide binding]; other site
208435003672	putative CoA binding site [chemical binding]; other site
208435003673	UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568
208435003674	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
208435003675	active site
208435003676	homodimer interface [polypeptide binding]; other site
208435003677	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
208435003678	NeuB family; Region: NeuB; pfam03102
208435003679	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
208435003680	NeuB binding interface [polypeptide binding]; other site
208435003681	putative substrate binding site [chemical binding]; other site
208435003682	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
208435003683	Polysaccharide biosynthesis protein; Region: Polysacc_synt; pfam01943
208435003684	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
208435003685	Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922
208435003686	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
208435003687	active site
208435003688	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
208435003689	active site
208435003690	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
208435003691	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
208435003692	active site
208435003693	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
208435003694	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; pfam04101
208435003695	Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660
208435003696	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
208435003697	Bacterial sugar transferase; Region: Bac_transf; pfam02397
208435003698	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
208435003699	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
208435003700	Chain length determinant protein; Region: Wzz; cl15801
208435003701	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
208435003702	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
208435003703	DNA polymerase processivity factor; Region: DNA_PPF; pfam02916
208435003704	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
208435003705	Transcriptional regulator [Transcription]; Region: LysR; COG0583
208435003706	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
208435003707	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
208435003708	dimerization interface [polypeptide binding]; other site
208435003709	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873
208435003710	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
208435003711	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
208435003712	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
208435003713	putative ion selectivity filter; other site
208435003714	putative pore gating glutamate residue; other site
208435003715	purine nucleoside phosphorylase; Provisional; Region: PRK08202
208435003716	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
208435003717	ArsC family; Region: ArsC; pfam03960
208435003718	catalytic residues [active]
208435003719	phosphopentomutase; Provisional; Region: PRK05362
208435003720	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
208435003721	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
208435003722	tetramer (dimer of dimers) interface [polypeptide binding]; other site
208435003723	active site
208435003724	dimer interface [polypeptide binding]; other site
208435003725	Nuclear pore assembly and biogenesis; Region: Apq12; pfam12716
208435003726	Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268
208435003727	active site
208435003728	S-formylglutathione hydrolase; Region: PLN02442
208435003729	Predicted esterase [General function prediction only]; Region: COG0627
208435003730	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
208435003731	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
208435003732	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
208435003733	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
208435003734	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
208435003735	Walker A/P-loop; other site
208435003736	ATP binding site [chemical binding]; other site
208435003737	Q-loop/lid; other site
208435003738	ABC transporter signature motif; other site
208435003739	Walker B; other site
208435003740	D-loop; other site
208435003741	H-loop/switch region; other site
208435003742	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
208435003743	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
208435003744	TM-ABC transporter signature motif; other site
208435003745	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
208435003746	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
208435003747	zinc binding site [ion binding]; other site
208435003748	putative ligand binding site [chemical binding]; other site
208435003749	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
208435003750	Domain of unknown function (DUF814); Region: DUF814; pfam05670
208435003751	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
208435003752	acetolactate synthase; Reviewed; Region: PRK08617
208435003753	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
208435003754	PYR/PP interface [polypeptide binding]; other site
208435003755	dimer interface [polypeptide binding]; other site
208435003756	TPP binding site [chemical binding]; other site
208435003757	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
208435003758	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
208435003759	TPP-binding site [chemical binding]; other site
208435003760	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
208435003761	binding surface
208435003762	TPR motif; other site
208435003763	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
208435003764	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
208435003765	Domain of unknown function DUF20; Region: UPF0118; pfam01594
208435003766	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
208435003767	nudix motif; other site
208435003768	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
208435003769	putative active site [active]
208435003770	nucleotide binding site [chemical binding]; other site
208435003771	nudix motif; other site
208435003772	putative metal binding site [ion binding]; other site
208435003773	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
208435003774	substrate binding site [chemical binding]; other site
208435003775	catalytic residues [active]
208435003776	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
208435003777	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
208435003778	NAD binding site [chemical binding]; other site
208435003779	substrate binding site [chemical binding]; other site
208435003780	homodimer interface [polypeptide binding]; other site
208435003781	active site
208435003782	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
208435003783	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
208435003784	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
208435003785	substrate binding site; other site
208435003786	tetramer interface; other site
208435003787	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
208435003788	Uncharacterized conserved protein [Function unknown]; Region: COG0327
208435003789	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
208435003790	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
208435003791	Family of unknown function (DUF633); Region: DUF633; pfam04816
208435003792	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
208435003793	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
208435003794	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
208435003795	active site
208435003796	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
208435003797	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
208435003798	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
208435003799	Clostridial hydrophobic W; Region: ChW; pfam07538
208435003800	Clostridial hydrophobic W; Region: ChW; pfam07538
208435003801	Clostridial hydrophobic W; Region: ChW; pfam07538
208435003802	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
208435003803	Clostridial hydrophobic W; Region: ChW; cl02763
208435003804	Clostridial hydrophobic W; Region: ChW; cl02763
208435003805	Clostridial hydrophobic W; Region: ChW; pfam07538
208435003806	Clostridial hydrophobic W; Region: ChW; cl02763
208435003807	Clostridial hydrophobic W; Region: ChW; pfam07538
208435003808	Clostridial hydrophobic W; Region: ChW; pfam07538
208435003809	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
208435003810	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
208435003811	putative active site [active]
208435003812	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
208435003813	DHH family; Region: DHH; pfam01368
208435003814	DHHA1 domain; Region: DHHA1; pfam02272
208435003815	Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141
208435003816	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
208435003817	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
208435003818	NAD(P) binding site [chemical binding]; other site
208435003819	active site
208435003820	ribonuclease Z; Region: RNase_Z; TIGR02651
208435003821	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
208435003822	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
208435003823	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
208435003824	HflX GTPase family; Region: HflX; cd01878
208435003825	G1 box; other site
208435003826	GTP/Mg2+ binding site [chemical binding]; other site
208435003827	Switch I region; other site
208435003828	G2 box; other site
208435003829	G3 box; other site
208435003830	Switch II region; other site
208435003831	G4 box; other site
208435003832	G5 box; other site
208435003833	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
208435003834	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
208435003835	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
208435003836	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
208435003837	gating phenylalanine in ion channel; other site
208435003838	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
208435003839	pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102
208435003840	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
208435003841	carbohydrate binding site [chemical binding]; other site
208435003842	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
208435003843	carbohydrate binding site [chemical binding]; other site
208435003844	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
208435003845	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
208435003846	Ca binding site [ion binding]; other site
208435003847	active site
208435003848	catalytic site [active]
208435003849	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
208435003850	putative uracil binding site [chemical binding]; other site
208435003851	putative active site [active]
208435003852	dipeptidase PepV; Reviewed; Region: PRK07318
208435003853	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
208435003854	active site
208435003855	metal binding site [ion binding]; metal-binding site
208435003856	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
208435003857	dimer interface [polypeptide binding]; other site
208435003858	FMN binding site [chemical binding]; other site
208435003859	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
208435003860	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
208435003861	GIY-YIG motif/motif A; other site
208435003862	active site
208435003863	catalytic site [active]
208435003864	putative DNA binding site [nucleotide binding]; other site
208435003865	metal binding site [ion binding]; metal-binding site
208435003866	UvrB/uvrC motif; Region: UVR; pfam02151
208435003867	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
208435003868	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
208435003869	multidrug efflux protein; Reviewed; Region: PRK01766
208435003870	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
208435003871	cation binding site [ion binding]; other site
208435003872	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
208435003873	dimer interface [polypeptide binding]; other site
208435003874	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
208435003875	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
208435003876	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
208435003877	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
208435003878	Transposase; Region: HTH_Tnp_1; pfam01527
208435003879	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
208435003880	HTH-like domain; Region: HTH_21; pfam13276
208435003881	Integrase core domain; Region: rve; pfam00665
208435003882	Integrase core domain; Region: rve_3; pfam13683
208435003883	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
208435003884	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
208435003885	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
208435003886	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
208435003887	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
208435003888	metal binding site [ion binding]; metal-binding site
208435003889	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
208435003890	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
208435003891	putative active site [active]
208435003892	putative NTP binding site [chemical binding]; other site
208435003893	putative nucleic acid binding site [nucleotide binding]; other site
208435003894	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
208435003895	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
208435003896	Transposase; Region: HTH_Tnp_1; pfam01527
208435003897	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
208435003898	Transposase; Region: HTH_Tnp_1; pfam01527
208435003899	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
208435003900	HTH-like domain; Region: HTH_21; pfam13276
208435003901	Integrase core domain; Region: rve; pfam00665
208435003902	Integrase core domain; Region: rve_3; pfam13683
208435003903	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
208435003904	Int/Topo IB signature motif; other site
208435003905	Domain of unknown function (DUF3173); Region: DUF3173; pfam11372
208435003906	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
208435003907	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
208435003908	non-specific DNA binding site [nucleotide binding]; other site
208435003909	salt bridge; other site
208435003910	sequence-specific DNA binding site [nucleotide binding]; other site
208435003911	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
208435003912	Lantibiotic streptin immunity protein; Region: Streptin-Immun; pfam11083
208435003913	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
208435003914	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
208435003915	Transposase; Region: DDE_Tnp_ISL3; pfam01610
208435003916	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
208435003917	metal-binding site [ion binding]
208435003918	mercuric reductase; Region: MerA; TIGR02053
208435003919	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
208435003920	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
208435003921	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
208435003922	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
208435003923	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
208435003924	DNA binding residues [nucleotide binding]
208435003925	dimer interface [polypeptide binding]; other site
208435003926	mercury binding site [ion binding]; other site
208435003927	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
208435003928	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
208435003929	metal-binding site [ion binding]
208435003930	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
208435003931	Soluble P-type ATPase [General function prediction only]; Region: COG4087
208435003932	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
208435003933	dimerization interface [polypeptide binding]; other site
208435003934	putative DNA binding site [nucleotide binding]; other site
208435003935	putative Zn2+ binding site [ion binding]; other site
208435003936	Protein of unknown function (DUF1461); Region: DUF1461; pfam07314
208435003937	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
208435003938	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
208435003939	Soluble P-type ATPase [General function prediction only]; Region: COG4087
208435003940	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
208435003941	metal-binding site [ion binding]
208435003942	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
208435003943	Penicillinase repressor; Region: Pencillinase_R; pfam03965
208435003944	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
208435003945	Cadmium resistance transporter; Region: Cad; pfam03596
208435003946	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
208435003947	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
208435003948	non-specific DNA binding site [nucleotide binding]; other site
208435003949	salt bridge; other site
208435003950	sequence-specific DNA binding site [nucleotide binding]; other site
208435003951	Predicted transcriptional regulator [Transcription]; Region: COG2932
208435003952	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
208435003953	Catalytic site [active]
208435003954	DNA polymerase IV; Reviewed; Region: PRK03103
208435003955	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
208435003956	active site
208435003957	DNA binding site [nucleotide binding]
208435003958	CHC2 zinc finger; Region: zf-CHC2; cl17510
208435003959	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
208435003960	Toprim-like; Region: Toprim_2; pfam13155
208435003961	sigma70 family sigma factor YlaC; Region: YlaC; pfam10777
208435003962	Methyltransferase domain; Region: Methyltransf_26; pfam13659
208435003963	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
208435003964	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
208435003965	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
208435003966	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
208435003967	helicase superfamily c-terminal domain; Region: HELICc; smart00490
208435003968	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
208435003969	Ca2+ binding site [ion binding]; other site
208435003970	Glucan-binding protein C; Region: GbpC; pfam08363
208435003971	adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228
208435003972	adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228
208435003973	adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228
208435003974	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
208435003975	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
208435003976	Peptidase family M23; Region: Peptidase_M23; pfam01551
208435003977	CHAP domain; Region: CHAP; pfam05257
208435003978	Domain of unknown function DUF87; Region: DUF87; pfam01935
208435003979	AAA-like domain; Region: AAA_10; pfam12846
208435003980	CAAX protease self-immunity; Region: Abi; pfam02517
208435003981	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
208435003982	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
208435003983	cofactor binding site; other site
208435003984	DNA binding site [nucleotide binding]
208435003985	substrate interaction site [chemical binding]; other site
208435003986	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
208435003987	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
208435003988	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
208435003989	core dimer interface [polypeptide binding]; other site
208435003990	L10 interface [polypeptide binding]; other site
208435003991	L11 interface [polypeptide binding]; other site
208435003992	putative EF-Tu interaction site [polypeptide binding]; other site
208435003993	putative EF-G interaction site [polypeptide binding]; other site
208435003994	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
208435003995	23S rRNA interface [nucleotide binding]; other site
208435003996	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
208435003997	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
208435003998	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
208435003999	Walker A motif; other site
208435004000	ATP binding site [chemical binding]; other site
208435004001	Walker B motif; other site
208435004002	arginine finger; other site
208435004003	UvrB/uvrC motif; Region: UVR; pfam02151
208435004004	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
208435004005	Walker A motif; other site
208435004006	ATP binding site [chemical binding]; other site
208435004007	Walker B motif; other site
208435004008	arginine finger; other site
208435004009	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
208435004010	homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485
208435004011	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
208435004012	S-methylmethionine transporter; Provisional; Region: PRK11387
208435004013	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
208435004014	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
208435004015	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
208435004016	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
208435004017	G1 box; other site
208435004018	GTP/Mg2+ binding site [chemical binding]; other site
208435004019	Switch I region; other site
208435004020	G2 box; other site
208435004021	G3 box; other site
208435004022	Switch II region; other site
208435004023	G4 box; other site
208435004024	G5 box; other site
208435004025	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
208435004026	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
208435004027	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
208435004028	Walker A motif; other site
208435004029	ATP binding site [chemical binding]; other site
208435004030	Walker B motif; other site
208435004031	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
208435004032	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
208435004033	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
208435004034	folate binding site [chemical binding]; other site
208435004035	NADP+ binding site [chemical binding]; other site
208435004036	thymidylate synthase; Reviewed; Region: thyA; PRK01827
208435004037	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
208435004038	dimerization interface [polypeptide binding]; other site
208435004039	active site
208435004040	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
208435004041	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
208435004042	dimer interface [polypeptide binding]; other site
208435004043	active site
208435004044	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
208435004045	homodimer interface [polypeptide binding]; other site
208435004046	catalytic residues [active]
208435004047	NAD binding site [chemical binding]; other site
208435004048	substrate binding pocket [chemical binding]; other site
208435004049	flexible flap; other site
208435004050	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
208435004051	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
208435004052	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
208435004053	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
208435004054	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
208435004055	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
208435004056	putative dimer interface [polypeptide binding]; other site
208435004057	N-terminal domain interface [polypeptide binding]; other site
208435004058	putative substrate binding pocket (H-site) [chemical binding]; other site
208435004059	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
208435004060	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
208435004061	homotetramer interface [polypeptide binding]; other site
208435004062	FMN binding site [chemical binding]; other site
208435004063	homodimer contacts [polypeptide binding]; other site
208435004064	putative active site [active]
208435004065	putative substrate binding site [chemical binding]; other site
208435004066	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
208435004067	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
208435004068	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
208435004069	diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240
208435004070	diphosphomevalonate decarboxylase; Region: PLN02407
208435004071	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
208435004072	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
208435004073	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
208435004074	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
208435004075	dimer interface [polypeptide binding]; other site
208435004076	phosphorylation site [posttranslational modification]
208435004077	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
208435004078	ATP binding site [chemical binding]; other site
208435004079	Mg2+ binding site [ion binding]; other site
208435004080	G-X-G motif; other site
208435004081	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
208435004082	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
208435004083	active site
208435004084	phosphorylation site [posttranslational modification]
208435004085	intermolecular recognition site; other site
208435004086	dimerization interface [polypeptide binding]; other site
208435004087	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
208435004088	DNA binding site [nucleotide binding]
208435004089	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
208435004090	synthetase active site [active]
208435004091	NTP binding site [chemical binding]; other site
208435004092	metal binding site [ion binding]; metal-binding site
208435004093	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
208435004094	Transcriptional regulators [Transcription]; Region: MarR; COG1846
208435004095	MarR family; Region: MarR_2; pfam12802
208435004096	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
208435004097	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
208435004098	putative active site [active]
208435004099	putative metal binding site [ion binding]; other site
208435004100	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
208435004101	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
208435004102	active site
208435004103	catalytic residues [active]
208435004104	metal binding site [ion binding]; metal-binding site
208435004105	glutamate dehydrogenase; Provisional; Region: PRK09414
208435004106	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
208435004107	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
208435004108	NAD(P) binding site [chemical binding]; other site
208435004109	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
208435004110	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
208435004111	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
208435004112	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
208435004113	Walker A/P-loop; other site
208435004114	ATP binding site [chemical binding]; other site
208435004115	Q-loop/lid; other site
208435004116	ABC transporter signature motif; other site
208435004117	Walker B; other site
208435004118	D-loop; other site
208435004119	H-loop/switch region; other site
208435004120	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
208435004121	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
208435004122	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
208435004123	Walker A/P-loop; other site
208435004124	ATP binding site [chemical binding]; other site
208435004125	Q-loop/lid; other site
208435004126	ABC transporter signature motif; other site
208435004127	Walker B; other site
208435004128	D-loop; other site
208435004129	H-loop/switch region; other site
208435004130	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
208435004131	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
208435004132	Coenzyme A binding pocket [chemical binding]; other site
208435004133	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
208435004134	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
208435004135	Walker A/P-loop; other site
208435004136	ATP binding site [chemical binding]; other site
208435004137	Q-loop/lid; other site
208435004138	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
208435004139	ABC transporter; Region: ABC_tran_2; pfam12848
208435004140	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
208435004141	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
208435004142	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
208435004143	active site
208435004144	NTP binding site [chemical binding]; other site
208435004145	metal binding triad [ion binding]; metal-binding site
208435004146	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
208435004147	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
208435004148	EDD domain protein, DegV family; Region: DegV; TIGR00762
208435004149	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
208435004150	Protein of unknown function (DUF1149); Region: DUF1149; pfam06619
208435004151	Predicted membrane protein (DUF2127); Region: DUF2127; cl01785
208435004152	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
208435004153	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
208435004154	active site
208435004155	phosphorylation site [posttranslational modification]
208435004156	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
208435004157	active site
208435004158	P-loop; other site
208435004159	phosphorylation site [posttranslational modification]
208435004160	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
208435004161	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
208435004162	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
208435004163	putative substrate binding site [chemical binding]; other site
208435004164	putative ATP binding site [chemical binding]; other site
208435004165	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
208435004166	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
208435004167	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
208435004168	FemAB family; Region: FemAB; pfam02388
208435004169	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
208435004170	Bacterial SH3 domain; Region: SH3_5; pfam08460
208435004171	Bacterial SH3 domain; Region: SH3_5; pfam08460
208435004172	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
208435004173	Bacterial SH3 domain; Region: SH3_5; pfam08460
208435004174	Bacterial SH3 domain; Region: SH3_5; pfam08460
208435004175	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
208435004176	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
208435004177	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
208435004178	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
208435004179	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
208435004180	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
208435004181	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
208435004182	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
208435004183	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
208435004184	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
208435004185	RimM N-terminal domain; Region: RimM; pfam01782
208435004186	M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280
208435004187	Mga helix-turn-helix domain; Region: Mga; pfam05043
208435004188	M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270
208435004189	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
208435004190	KH domain; Region: KH_4; pfam13083
208435004191	G-X-X-G motif; other site
208435004192	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
208435004193	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
208435004194	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
208435004195	FtsX-like permease family; Region: FtsX; pfam02687
208435004196	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
208435004197	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
208435004198	Walker A/P-loop; other site
208435004199	ATP binding site [chemical binding]; other site
208435004200	Q-loop/lid; other site
208435004201	ABC transporter signature motif; other site
208435004202	Walker B; other site
208435004203	D-loop; other site
208435004204	H-loop/switch region; other site
208435004205	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
208435004206	HlyD family secretion protein; Region: HlyD_3; pfam13437
208435004207	ATP-grasp domain; Region: ATP-grasp_4; cl17255
208435004208	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
208435004209	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838
208435004210	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
208435004211	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
208435004212	catalytic site [active]
208435004213	subunit interface [polypeptide binding]; other site
208435004214	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
208435004215	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
208435004216	active site
208435004217	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
208435004218	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
208435004219	RNA binding surface [nucleotide binding]; other site
208435004220	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
208435004221	active site
208435004222	lipoprotein signal peptidase; Provisional; Region: PRK14797
208435004223	Transcriptional regulator [Transcription]; Region: LysR; COG0583
208435004224	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
208435004225	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
208435004226	dimerization interface [polypeptide binding]; other site
208435004227	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
208435004228	Protein of unknown function (DUF464); Region: DUF464; pfam04327
208435004229	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
208435004230	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
208435004231	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
208435004232	putative active site [active]
208435004233	putative metal binding site [ion binding]; other site
208435004234	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
208435004235	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
208435004236	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
208435004237	Ligand Binding Site [chemical binding]; other site
208435004238	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
208435004239	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
208435004240	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
208435004241	catalytic residue [active]
208435004242	glutathione reductase; Validated; Region: PRK06116
208435004243	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
208435004244	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
208435004245	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
208435004246	hypothetical protein; Provisional; Region: PRK13676
208435004247	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
208435004248	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
208435004249	Tetramer interface [polypeptide binding]; other site
208435004250	active site
208435004251	FMN-binding site [chemical binding]; other site
208435004252	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
208435004253	active site
208435004254	dimer interface [polypeptide binding]; other site
208435004255	metal binding site [ion binding]; metal-binding site
208435004256	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
208435004257	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
208435004258	active site
208435004259	catalytic residue [active]
208435004260	dimer interface [polypeptide binding]; other site
208435004261	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
208435004262	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
208435004263	putative RNA binding site [nucleotide binding]; other site
208435004264	Methyltransferase domain; Region: Methyltransf_26; pfam13659
208435004265	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
208435004266	Sulfatase; Region: Sulfatase; pfam00884
208435004267	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
208435004268	23S rRNA binding site [nucleotide binding]; other site
208435004269	L21 binding site [polypeptide binding]; other site
208435004270	L13 binding site [polypeptide binding]; other site
208435004271	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
208435004272	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
208435004273	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
208435004274	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
208435004275	cytidylate kinase; Provisional; Region: cmk; PRK00023
208435004276	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
208435004277	CMP-binding site; other site
208435004278	The sites determining sugar specificity; other site
208435004279	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
208435004280	peptidase T; Region: peptidase-T; TIGR01882
208435004281	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
208435004282	metal binding site [ion binding]; metal-binding site
208435004283	dimer interface [polypeptide binding]; other site
208435004284	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
208435004285	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
208435004286	UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022
208435004287	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
208435004288	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
208435004289	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
208435004290	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
208435004291	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
208435004292	Walker A/P-loop; other site
208435004293	ATP binding site [chemical binding]; other site
208435004294	Q-loop/lid; other site
208435004295	ABC transporter signature motif; other site
208435004296	Walker B; other site
208435004297	D-loop; other site
208435004298	H-loop/switch region; other site
208435004299	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
208435004300	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
208435004301	intersubunit interface [polypeptide binding]; other site
208435004302	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
208435004303	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
208435004304	ABC-ATPase subunit  interface; other site
208435004305	dimer interface [polypeptide binding]; other site
208435004306	putative PBP binding regions; other site
208435004307	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
208435004308	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
208435004309	ABC-ATPase subunit  interface; other site
208435004310	dimer interface [polypeptide binding]; other site
208435004311	putative PBP binding regions; other site
208435004312	Domain of unknown function (DUF1803); Region: DUF1803; pfam08820
208435004313	Domain of unknown function (DUF1803); Region: DUF1803; pfam08820
208435004314	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
208435004315	DHH family; Region: DHH; pfam01368
208435004316	DHHA2 domain; Region: DHHA2; pfam02833
208435004317	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
208435004318	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
208435004319	FeS/SAM binding site; other site
208435004320	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
208435004321	Domain of unknown function DUF21; Region: DUF21; pfam01595
208435004322	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
208435004323	Transporter associated domain; Region: CorC_HlyC; smart01091
208435004324	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
208435004325	S-adenosylmethionine binding site [chemical binding]; other site
208435004326	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
208435004327	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
208435004328	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
208435004329	active site
208435004330	Predicted membrane protein [Function unknown]; Region: COG3601
208435004331	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
208435004332	Cna protein B-type domain; Region: Cna_B; pfam05738
208435004333	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
208435004334	active site
208435004335	catalytic site [active]
208435004336	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
208435004337	active site
208435004338	catalytic site [active]
208435004339	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
208435004340	Cna protein B-type domain; Region: Cna_B; pfam05738
208435004341	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
208435004342	metal ion-dependent adhesion site (MIDAS); other site
208435004343	Cna protein B-type domain; Region: Cna_B; pfam05738
208435004344	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
208435004345	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
208435004346	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
208435004347	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
208435004348	active site
208435004349	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
208435004350	Polysaccharide biosynthesis protein; Region: Polysacc_synt; pfam01943
208435004351	Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913
208435004352	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
208435004353	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
208435004354	active site
208435004355	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
208435004356	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
208435004357	Probable Catalytic site; other site
208435004358	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
208435004359	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
208435004360	NAD(P) binding site [chemical binding]; other site
208435004361	active site
208435004362	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
208435004363	substrate binding site; other site
208435004364	dimer interface; other site
208435004365	LicD family; Region: LicD; cl01378
208435004366	Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034
208435004367	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
208435004368	Ligand binding site; other site
208435004369	Putative Catalytic site; other site
208435004370	DXD motif; other site
208435004371	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
208435004372	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
208435004373	Probable Catalytic site; other site
208435004374	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
208435004375	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
208435004376	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
208435004377	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
208435004378	NADP binding site [chemical binding]; other site
208435004379	active site
208435004380	putative substrate binding site [chemical binding]; other site
208435004381	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
208435004382	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
208435004383	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
208435004384	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
208435004385	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
208435004386	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
208435004387	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
208435004388	DNA binding residues [nucleotide binding]
208435004389	DNA primase; Validated; Region: dnaG; PRK05667
208435004390	CHC2 zinc finger; Region: zf-CHC2; pfam01807
208435004391	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
208435004392	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
208435004393	active site
208435004394	metal binding site [ion binding]; metal-binding site
208435004395	interdomain interaction site; other site
208435004396	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
208435004397	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
208435004398	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
208435004399	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
208435004400	Flagellin N-methylase; Region: FliB; pfam03692
208435004401	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
208435004402	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
208435004403	substrate binding pocket [chemical binding]; other site
208435004404	membrane-bound complex binding site; other site
208435004405	hinge residues; other site
208435004406	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
208435004407	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
208435004408	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
208435004409	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
208435004410	active site residue [active]
208435004411	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
208435004412	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
208435004413	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
208435004414	putative substrate translocation pore; other site
208435004415	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
208435004416	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
208435004417	4-alpha-glucanotransferase; Provisional; Region: PRK14508
208435004418	Transcriptional regulators [Transcription]; Region: PurR; COG1609
208435004419	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
208435004420	DNA binding site [nucleotide binding]
208435004421	domain linker motif; other site
208435004422	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
208435004423	putative dimerization interface [polypeptide binding]; other site
208435004424	putative ligand binding site [chemical binding]; other site
208435004425	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
208435004426	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
208435004427	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
208435004428	dimer interface [polypeptide binding]; other site
208435004429	conserved gate region; other site
208435004430	putative PBP binding loops; other site
208435004431	ABC-ATPase subunit interface; other site
208435004432	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
208435004433	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
208435004434	dimer interface [polypeptide binding]; other site
208435004435	conserved gate region; other site
208435004436	putative PBP binding loops; other site
208435004437	ABC-ATPase subunit interface; other site
208435004438	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
208435004439	putative substrate translocation pore; other site
208435004440	POT family; Region: PTR2; cl17359
208435004441	accessory Sec system glycosyltransferase GtfB; Region: TIGR02919
208435004442	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
208435004443	accessory Sec system glycosylation protein GtfA; Region: TIGR02918
208435004444	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
208435004445	accessory Sec system translocase SecA2; Region: secA2; TIGR03714
208435004446	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
208435004447	ATP binding site [chemical binding]; other site
208435004448	putative Mg++ binding site [ion binding]; other site
208435004449	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
208435004450	accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711
208435004451	accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712
208435004452	accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713
208435004453	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
208435004454	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417
208435004455	SecY translocase; Region: SecY; pfam00344
208435004456	glycosyltransferase, SP_1767 family; Region: glyco_access_1; TIGR03728
208435004457	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
208435004458	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
208435004459	active site
208435004460	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
208435004461	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
208435004462	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
208435004463	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
208435004464	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
208435004465	Ligand binding site; other site
208435004466	metal-binding site
208435004467	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
208435004468	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
208435004469	Ligand binding site; other site
208435004470	metal-binding site
208435004471	beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814
208435004472	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
208435004473	serine-rich repeat adhesion glycoprotein AST domain; Region: ser_adhes_Nterm; TIGR04224
208435004474	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
208435004475	excinuclease ABC subunit B; Provisional; Region: PRK05298
208435004476	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
208435004477	ATP binding site [chemical binding]; other site
208435004478	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
208435004479	nucleotide binding region [chemical binding]; other site
208435004480	ATP-binding site [chemical binding]; other site
208435004481	Ultra-violet resistance protein B; Region: UvrB; pfam12344
208435004482	CAAX protease self-immunity; Region: Abi; pfam02517
208435004483	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
208435004484	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
208435004485	substrate binding pocket [chemical binding]; other site
208435004486	membrane-bound complex binding site; other site
208435004487	hinge residues; other site
208435004488	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
208435004489	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
208435004490	substrate binding pocket [chemical binding]; other site
208435004491	membrane-bound complex binding site; other site
208435004492	hinge residues; other site
208435004493	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
208435004494	dimer interface [polypeptide binding]; other site
208435004495	conserved gate region; other site
208435004496	putative PBP binding loops; other site
208435004497	ABC-ATPase subunit interface; other site
208435004498	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
208435004499	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
208435004500	Walker A/P-loop; other site
208435004501	ATP binding site [chemical binding]; other site
208435004502	Q-loop/lid; other site
208435004503	ABC transporter signature motif; other site
208435004504	Walker B; other site
208435004505	D-loop; other site
208435004506	H-loop/switch region; other site
208435004507	GTPase CgtA; Reviewed; Region: obgE; PRK12297
208435004508	GTP1/OBG; Region: GTP1_OBG; pfam01018
208435004509	Obg GTPase; Region: Obg; cd01898
208435004510	G1 box; other site
208435004511	GTP/Mg2+ binding site [chemical binding]; other site
208435004512	Switch I region; other site
208435004513	G2 box; other site
208435004514	G3 box; other site
208435004515	Switch II region; other site
208435004516	G4 box; other site
208435004517	G5 box; other site
208435004518	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
208435004519	Protein of unknown function (DUF4044); Region: DUF4044; pfam13253
208435004520	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
208435004521	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
208435004522	amidase; Provisional; Region: PRK06529
208435004523	Amidase; Region: Amidase; cl11426
208435004524	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
208435004525	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
208435004526	RNA binding surface [nucleotide binding]; other site
208435004527	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
208435004528	active site
208435004529	uracil binding [chemical binding]; other site
208435004530	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
208435004531	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
208435004532	active site
208435004533	catalytic tetrad [active]
208435004534	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
208435004535	dimer interface [polypeptide binding]; other site
208435004536	FMN binding site [chemical binding]; other site
208435004537	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
208435004538	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
208435004539	dimer interface [polypeptide binding]; other site
208435004540	active site
208435004541	metal binding site [ion binding]; metal-binding site
208435004542	glutathione binding site [chemical binding]; other site
208435004543	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
208435004544	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
208435004545	Ligand binding site; other site
208435004546	Putative Catalytic site; other site
208435004547	DXD motif; other site
208435004548	Amino acid permease; Region: AA_permease_2; pfam13520
208435004549	Spore germination protein; Region: Spore_permease; cl17796
208435004550	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
208435004551	SmpB-tmRNA interface; other site
208435004552	ribonuclease R; Region: RNase_R; TIGR02063
208435004553	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
208435004554	RNB domain; Region: RNB; pfam00773
208435004555	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
208435004556	RNA binding site [nucleotide binding]; other site
208435004557	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
208435004558	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
208435004559	drug efflux system protein MdtG; Provisional; Region: PRK09874
208435004560	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
208435004561	putative substrate translocation pore; other site
208435004562	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
208435004563	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
208435004564	Walker A/P-loop; other site
208435004565	ATP binding site [chemical binding]; other site
208435004566	Q-loop/lid; other site
208435004567	ABC transporter signature motif; other site
208435004568	Walker B; other site
208435004569	D-loop; other site
208435004570	H-loop/switch region; other site
208435004571	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
208435004572	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
208435004573	CoA-binding site [chemical binding]; other site
208435004574	ATP-binding [chemical binding]; other site
208435004575	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
208435004576	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
208435004577	DNA binding site [nucleotide binding]
208435004578	catalytic residue [active]
208435004579	H2TH interface [polypeptide binding]; other site
208435004580	putative catalytic residues [active]
208435004581	turnover-facilitating residue; other site
208435004582	intercalation triad [nucleotide binding]; other site
208435004583	8OG recognition residue [nucleotide binding]; other site
208435004584	putative reading head residues; other site
208435004585	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
208435004586	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
208435004587	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
208435004588	sequence-specific DNA binding site [nucleotide binding]; other site
208435004589	salt bridge; other site
208435004590	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
208435004591	Transglutaminase/protease-like homologues; Region: TGc; smart00460
208435004592	CAAX protease self-immunity; Region: Abi; pfam02517
208435004593	GTPase Era; Reviewed; Region: era; PRK00089
208435004594	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
208435004595	G1 box; other site
208435004596	GTP/Mg2+ binding site [chemical binding]; other site
208435004597	Switch I region; other site
208435004598	G2 box; other site
208435004599	Switch II region; other site
208435004600	G3 box; other site
208435004601	G4 box; other site
208435004602	G5 box; other site
208435004603	KH domain; Region: KH_2; pfam07650
208435004604	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
208435004605	metal-binding heat shock protein; Provisional; Region: PRK00016
208435004606	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
208435004607	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
208435004608	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
208435004609	nudix motif; other site
208435004610	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
208435004611	PhoH-like protein; Region: PhoH; pfam02562
208435004612	myosin-cross-reactive antigen; Provisional; Region: PRK13977
208435004613	hypothetical protein; Provisional; Region: PRK13672
208435004614	methionine sulfoxide reductase A; Provisional; Region: PRK14054
208435004615	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
208435004616	S1 domain; Region: S1_2; pfam13509
208435004617	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
208435004618	ribosome recycling factor; Reviewed; Region: frr; PRK00083
208435004619	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
208435004620	hinge region; other site
208435004621	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
208435004622	putative nucleotide binding site [chemical binding]; other site
208435004623	uridine monophosphate binding site [chemical binding]; other site
208435004624	homohexameric interface [polypeptide binding]; other site
208435004625	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
208435004626	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
208435004627	Walker A/P-loop; other site
208435004628	ATP binding site [chemical binding]; other site
208435004629	Q-loop/lid; other site
208435004630	ABC transporter signature motif; other site
208435004631	Walker B; other site
208435004632	D-loop; other site
208435004633	H-loop/switch region; other site
208435004634	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
208435004635	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
208435004636	Walker A/P-loop; other site
208435004637	ATP binding site [chemical binding]; other site
208435004638	Q-loop/lid; other site
208435004639	ABC transporter signature motif; other site
208435004640	Walker B; other site
208435004641	D-loop; other site
208435004642	H-loop/switch region; other site
208435004643	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
208435004644	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
208435004645	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
208435004646	dimer interface [polypeptide binding]; other site
208435004647	conserved gate region; other site
208435004648	putative PBP binding loops; other site
208435004649	ABC-ATPase subunit interface; other site
208435004650	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
208435004651	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
208435004652	dimer interface [polypeptide binding]; other site
208435004653	conserved gate region; other site
208435004654	putative PBP binding loops; other site
208435004655	ABC-ATPase subunit interface; other site
208435004656	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
208435004657	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
208435004658	substrate binding site [chemical binding]; other site
208435004659	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
208435004660	mRNA/rRNA interface [nucleotide binding]; other site
208435004661	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
208435004662	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
208435004663	23S rRNA interface [nucleotide binding]; other site
208435004664	L7/L12 interface [polypeptide binding]; other site
208435004665	putative thiostrepton binding site; other site
208435004666	L25 interface [polypeptide binding]; other site
208435004667	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
208435004668	Helix-turn-helix domain; Region: HTH_38; pfam13936
208435004669	Integrase core domain; Region: rve; pfam00665
208435004670	Major Facilitator Superfamily; Region: MFS_1; pfam07690
208435004671	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
208435004672	putative substrate translocation pore; other site
208435004673	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
208435004674	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
208435004675	metal binding site [ion binding]; metal-binding site
208435004676	dimer interface [polypeptide binding]; other site
208435004677	Transcriptional regulator [Transcription]; Region: LysR; COG0583
208435004678	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
208435004679	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
208435004680	dimerization interface [polypeptide binding]; other site
208435004681	Protein of unknown function (DUF3397); Region: DUF3397; pfam11877
208435004682	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
208435004683	putative transposase OrfB; Reviewed; Region: PHA02517
208435004684	HTH-like domain; Region: HTH_21; pfam13276
208435004685	Integrase core domain; Region: rve; pfam00665
208435004686	Integrase core domain; Region: rve_2; pfam13333
208435004687	aminodeoxychorismate synthase; Provisional; Region: PRK07508
208435004688	chorismate binding enzyme; Region: Chorismate_bind; cl10555
208435004689	substrate-cofactor binding pocket; other site
208435004690	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
208435004691	Aminotransferase class IV; Region: Aminotran_4; pfam01063
208435004692	pyridoxal 5'-phosphate binding site [chemical binding]; other site
208435004693	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
208435004694	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
208435004695	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
208435004696	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652
208435004697	active site
208435004698	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
208435004699	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
208435004700	ABC-ATPase subunit  interface; other site
208435004701	dimer interface [polypeptide binding]; other site
208435004702	putative PBP binding regions; other site
208435004703	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
208435004704	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
208435004705	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
208435004706	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
208435004707	metal binding site [ion binding]; metal-binding site
208435004708	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
208435004709	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
208435004710	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
208435004711	FeoA domain; Region: FeoA; pfam04023
208435004712	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
208435004713	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
208435004714	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
208435004715	dimer interface [polypeptide binding]; other site
208435004716	ADP-ribose binding site [chemical binding]; other site
208435004717	active site
208435004718	nudix motif; other site
208435004719	metal binding site [ion binding]; metal-binding site
208435004720	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
208435004721	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
208435004722	Substrate binding site; other site
208435004723	Mg++ binding site; other site
208435004724	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
208435004725	active site
208435004726	substrate binding site [chemical binding]; other site
208435004727	CoA binding site [chemical binding]; other site
208435004728	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
208435004729	dimer interface [polypeptide binding]; other site
208435004730	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
208435004731	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
208435004732	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
208435004733	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
208435004734	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550
208435004735	classical (c) SDRs; Region: SDR_c; cd05233
208435004736	NAD(P) binding site [chemical binding]; other site
208435004737	active site
208435004738	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
208435004739	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
208435004740	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
208435004741	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
208435004742	Coenzyme A binding pocket [chemical binding]; other site
208435004743	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
208435004744	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
208435004745	DXD motif; other site
208435004746	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
208435004747	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
208435004748	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
208435004749	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
208435004750	CotH protein; Region: CotH; pfam08757
208435004751	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
208435004752	Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
208435004753	putative metal binding residues [ion binding]; other site
208435004754	signature motif; other site
208435004755	dimer interface [polypeptide binding]; other site
208435004756	active site
208435004757	polyP binding site; other site
208435004758	substrate binding site [chemical binding]; other site
208435004759	acceptor-phosphate pocket; other site
208435004760	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
208435004761	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
208435004762	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
208435004763	active site
208435004764	HIGH motif; other site
208435004765	KMSKS motif; other site
208435004766	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
208435004767	tRNA binding surface [nucleotide binding]; other site
208435004768	anticodon binding site; other site
208435004769	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
208435004770	dimer interface [polypeptide binding]; other site
208435004771	putative tRNA-binding site [nucleotide binding]; other site
208435004772	tellurite resistance protein TehB; Provisional; Region: PRK12335
208435004773	Domain of unknown function (DUF1971); Region: DUF1971; pfam09313
208435004774	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
208435004775	S-adenosylmethionine binding site [chemical binding]; other site
208435004776	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
208435004777	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
208435004778	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
208435004779	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
208435004780	active site
208435004781	putative catalytic site [active]
208435004782	DNA binding site [nucleotide binding]
208435004783	putative phosphate binding site [ion binding]; other site
208435004784	metal binding site A [ion binding]; metal-binding site
208435004785	AP binding site [nucleotide binding]; other site
208435004786	metal binding site B [ion binding]; metal-binding site
208435004787	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
208435004788	ArsC family; Region: ArsC; pfam03960
208435004789	putative ArsC-like catalytic residues; other site
208435004790	putative TRX-like catalytic residues [active]
208435004791	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
208435004792	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
208435004793	DNA binding site [nucleotide binding]
208435004794	active site
208435004795	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
208435004796	putative ligand binding site [chemical binding]; other site
208435004797	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
208435004798	putative NAD binding site [chemical binding]; other site
208435004799	putative catalytic site [active]
208435004800	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
208435004801	L-serine binding site [chemical binding]; other site
208435004802	ACT domain interface; other site
208435004803	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
208435004804	Predicted methyltransferases [General function prediction only]; Region: COG0313
208435004805	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
208435004806	putative SAM binding site [chemical binding]; other site
208435004807	putative homodimer interface [polypeptide binding]; other site
208435004808	DNA replication intiation control protein YabA; Reviewed; Region: PRK13169
208435004809	DNA polymerase III subunit delta'; Validated; Region: PRK07276
208435004810	DNA polymerase III subunit delta'; Validated; Region: PRK08485
208435004811	thymidylate kinase; Validated; Region: tmk; PRK00698
208435004812	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
208435004813	TMP-binding site; other site
208435004814	ATP-binding site [chemical binding]; other site
208435004815	FOG: CBS domain [General function prediction only]; Region: COG0517
208435004816	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
208435004817	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
208435004818	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
208435004819	Walker A/P-loop; other site
208435004820	ATP binding site [chemical binding]; other site
208435004821	Q-loop/lid; other site
208435004822	ABC transporter signature motif; other site
208435004823	Walker B; other site
208435004824	D-loop; other site
208435004825	H-loop/switch region; other site
208435004826	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
208435004827	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
208435004828	Walker A/P-loop; other site
208435004829	ATP binding site [chemical binding]; other site
208435004830	Q-loop/lid; other site
208435004831	ABC transporter signature motif; other site
208435004832	Walker B; other site
208435004833	D-loop; other site
208435004834	H-loop/switch region; other site
208435004835	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
208435004836	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
208435004837	TM-ABC transporter signature motif; other site
208435004838	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
208435004839	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
208435004840	TM-ABC transporter signature motif; other site
208435004841	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
208435004842	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
208435004843	putative ligand binding site [chemical binding]; other site
208435004844	hypothetical protein; Provisional; Region: PRK02302
208435004845	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
208435004846	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
208435004847	Transposase [DNA replication, recombination, and repair]; Region: COG5433
208435004848	Clp protease; Region: CLP_protease; pfam00574
208435004849	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
208435004850	oligomer interface [polypeptide binding]; other site
208435004851	active site residues [active]
208435004852	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
208435004853	active site
208435004854	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
208435004855	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
208435004856	pyridoxal 5'-phosphate binding site [chemical binding]; other site
208435004857	homodimer interface [polypeptide binding]; other site
208435004858	catalytic residue [active]
208435004859	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
208435004860	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
208435004861	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
208435004862	TrkA-N domain; Region: TrkA_N; pfam02254
208435004863	TrkA-C domain; Region: TrkA_C; pfam02080
208435004864	TrkA-N domain; Region: TrkA_N; pfam02254
208435004865	TrkA-C domain; Region: TrkA_C; pfam02080
208435004866	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
208435004867	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
208435004868	hypothetical protein; Validated; Region: PRK00041
208435004869	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
208435004870	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
208435004871	RNA binding surface [nucleotide binding]; other site
208435004872	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
208435004873	active site
208435004874	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
208435004875	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
208435004876	site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436
208435004877	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
208435004878	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
208435004879	DNA binding site [nucleotide binding]
208435004880	Int/Topo IB signature motif; other site
208435004881	active site
208435004882	catalytic residues [active]
208435004883	FOG: CBS domain [General function prediction only]; Region: COG0517
208435004884	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
208435004885	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
208435004886	active site
208435004887	metal binding site [ion binding]; metal-binding site
208435004888	homotetramer interface [polypeptide binding]; other site
208435004889	putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491
208435004890	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
208435004891	active site
208435004892	dimerization interface [polypeptide binding]; other site
208435004893	glutamate racemase; Provisional; Region: PRK00865
208435004894	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763
208435004895	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
208435004896	HTH domain; Region: HTH_11; pfam08279
208435004897	3H domain; Region: 3H; pfam02829
208435004898	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
208435004899	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
208435004900	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
208435004901	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
208435004902	substrate binding site [chemical binding]; other site
208435004903	activation loop (A-loop); other site
208435004904	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
208435004905	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
208435004906	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
208435004907	acylphosphatase; Provisional; Region: PRK14434
208435004908	OxaA-like protein precursor; Provisional; Region: PRK02463
208435004909	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
208435004910	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
208435004911	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
208435004912	dimer interface [polypeptide binding]; other site
208435004913	conserved gate region; other site
208435004914	putative PBP binding loops; other site
208435004915	ABC-ATPase subunit interface; other site
208435004916	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
208435004917	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
208435004918	substrate binding pocket [chemical binding]; other site
208435004919	membrane-bound complex binding site; other site
208435004920	hinge residues; other site
208435004921	amidase; Provisional; Region: PRK06529
208435004922	Amidase; Region: Amidase; cl11426
208435004923	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
208435004924	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
208435004925	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
208435004926	Domain of unknown function (DUF4200); Region: DUF4200; pfam13863
208435004927	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
208435004928	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
208435004929	dimerization interface [polypeptide binding]; other site
208435004930	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
208435004931	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
208435004932	Coenzyme A binding pocket [chemical binding]; other site
208435004933	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
208435004934	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
208435004935	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
208435004936	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
208435004937	SWIM zinc finger; Region: SWIM; pfam04434
208435004938	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
208435004939	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
208435004940	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
208435004941	ATP binding site [chemical binding]; other site
208435004942	putative Mg++ binding site [ion binding]; other site
208435004943	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
208435004944	nucleotide binding region [chemical binding]; other site
208435004945	ATP-binding site [chemical binding]; other site
208435004946	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
208435004947	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
208435004948	Transposase [DNA replication, recombination, and repair]; Region: COG5433
208435004949	GTP-binding protein Der; Reviewed; Region: PRK00093
208435004950	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
208435004951	G1 box; other site
208435004952	GTP/Mg2+ binding site [chemical binding]; other site
208435004953	Switch I region; other site
208435004954	G2 box; other site
208435004955	Switch II region; other site
208435004956	G3 box; other site
208435004957	G4 box; other site
208435004958	G5 box; other site
208435004959	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
208435004960	G1 box; other site
208435004961	GTP/Mg2+ binding site [chemical binding]; other site
208435004962	Switch I region; other site
208435004963	G2 box; other site
208435004964	G3 box; other site
208435004965	Switch II region; other site
208435004966	G4 box; other site
208435004967	G5 box; other site
208435004968	primosomal protein DnaI; Reviewed; Region: PRK08939
208435004969	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
208435004970	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
208435004971	Walker A motif; other site
208435004972	ATP binding site [chemical binding]; other site
208435004973	Walker B motif; other site
208435004974	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
208435004975	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
208435004976	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
208435004977	Transcription factor S-II (TFIIS); Region: TFIIS_C; cl02609
208435004978	ATP cone domain; Region: ATP-cone; pfam03477
208435004979	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
208435004980	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
208435004981	dimerization interface [polypeptide binding]; other site
208435004982	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
208435004983	dimer interface [polypeptide binding]; other site
208435004984	phosphorylation site [posttranslational modification]
208435004985	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
208435004986	ATP binding site [chemical binding]; other site
208435004987	Mg2+ binding site [ion binding]; other site
208435004988	G-X-G motif; other site
208435004989	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
208435004990	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
208435004991	active site
208435004992	phosphorylation site [posttranslational modification]
208435004993	intermolecular recognition site; other site
208435004994	dimerization interface [polypeptide binding]; other site
208435004995	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
208435004996	DNA binding site [nucleotide binding]
208435004997	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
208435004998	heat shock protein HtpX; Provisional; Region: PRK04897
208435004999	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
208435005000	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
208435005001	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
208435005002	S-adenosylmethionine binding site [chemical binding]; other site
208435005003	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
208435005004	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
208435005005	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
208435005006	TrkA-N domain; Region: TrkA_N; pfam02254
208435005007	TrkA-C domain; Region: TrkA_C; pfam02080
208435005008	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
208435005009	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
208435005010	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
208435005011	Walker A/P-loop; other site
208435005012	ATP binding site [chemical binding]; other site
208435005013	Q-loop/lid; other site
208435005014	ABC transporter signature motif; other site
208435005015	Walker B; other site
208435005016	D-loop; other site
208435005017	H-loop/switch region; other site
208435005018	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
208435005019	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
208435005020	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
208435005021	Walker A/P-loop; other site
208435005022	ATP binding site [chemical binding]; other site
208435005023	Q-loop/lid; other site
208435005024	ABC transporter signature motif; other site
208435005025	Walker B; other site
208435005026	D-loop; other site
208435005027	H-loop/switch region; other site
208435005028	hypothetical protein; Provisional; Region: PRK13661
208435005029	serine/threonine transporter SstT; Provisional; Region: PRK13628
208435005030	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
208435005031	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
208435005032	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286
208435005033	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
208435005034	catalytic Zn binding site [ion binding]; other site
208435005035	structural Zn binding site [ion binding]; other site
208435005036	NAD(P) binding site [chemical binding]; other site
208435005037	ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011
208435005038	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
208435005039	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
208435005040	Walker A/P-loop; other site
208435005041	ATP binding site [chemical binding]; other site
208435005042	Q-loop/lid; other site
208435005043	ABC transporter signature motif; other site
208435005044	Walker B; other site
208435005045	D-loop; other site
208435005046	H-loop/switch region; other site
208435005047	NIL domain; Region: NIL; pfam09383
208435005048	hypothetical protein; Provisional; Region: PRK06446
208435005049	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681
208435005050	metal binding site [ion binding]; metal-binding site
208435005051	dimer interface [polypeptide binding]; other site
208435005052	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
208435005053	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
208435005054	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
208435005055	substrate binding pocket [chemical binding]; other site
208435005056	membrane-bound complex binding site; other site
208435005057	hinge residues; other site
208435005058	Peptidase C26; Region: Peptidase_C26; pfam07722
208435005059	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
208435005060	catalytic triad [active]
208435005061	hypothetical protein; Provisional; Region: PRK12378
208435005062	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
208435005063	probable dihydroxyacetone kinase DhaK1b subunit; Region: dhaK1b; TIGR02362
208435005064	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
208435005065	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
208435005066	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
208435005067	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
208435005068	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
208435005069	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
208435005070	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
208435005071	amphipathic channel; other site
208435005072	Asn-Pro-Ala signature motifs; other site
208435005073	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
208435005074	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
208435005075	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
208435005076	DNA binding residues [nucleotide binding]
208435005077	dimer interface [polypeptide binding]; other site
208435005078	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
208435005079	hypothetical protein; Provisional; Region: PRK13670
208435005080	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636
208435005081	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
208435005082	S-adenosylmethionine binding site [chemical binding]; other site
208435005083	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
208435005084	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
208435005085	catalytic triad [active]
208435005086	conserved cis-peptide bond; other site
208435005087	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
208435005088	Zn2+ binding site [ion binding]; other site
208435005089	Mg2+ binding site [ion binding]; other site
208435005090	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
208435005091	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
208435005092	active site
208435005093	(T/H)XGH motif; other site
208435005094	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
208435005095	GTPase YqeH; Provisional; Region: PRK13796
208435005096	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
208435005097	GTP/Mg2+ binding site [chemical binding]; other site
208435005098	G4 box; other site
208435005099	G5 box; other site
208435005100	G1 box; other site
208435005101	Switch I region; other site
208435005102	G2 box; other site
208435005103	G3 box; other site
208435005104	Switch II region; other site
208435005105	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
208435005106	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
208435005107	active site
208435005108	motif I; other site
208435005109	motif II; other site
208435005110	EamA-like transporter family; Region: EamA; pfam00892
208435005111	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
208435005112	EamA-like transporter family; Region: EamA; pfam00892
208435005113	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
208435005114	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
208435005115	GatB domain; Region: GatB_Yqey; pfam02637
208435005116	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
208435005117	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
208435005118	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
208435005119	pyruvate phosphate dikinase; Provisional; Region: PRK09279
208435005120	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
208435005121	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
208435005122	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
208435005123	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
208435005124	PEP synthetase regulatory protein; Provisional; Region: PRK05339
208435005125	FOG: CBS domain [General function prediction only]; Region: COG0517
208435005126	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
208435005127	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293
208435005128	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
208435005129	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
208435005130	Isochorismatase family; Region: Isochorismatase; pfam00857
208435005131	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
208435005132	catalytic triad [active]
208435005133	conserved cis-peptide bond; other site
208435005134	transcriptional repressor CodY; Validated; Region: PRK04158
208435005135	CodY GAF-like domain; Region: CodY; pfam06018
208435005136	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
208435005137	dimerization interface [polypeptide binding]; other site
208435005138	putative Zn2+ binding site [ion binding]; other site
208435005139	putative DNA binding site [nucleotide binding]; other site
208435005140	aminotransferase AlaT; Validated; Region: PRK09265
208435005141	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
208435005142	pyridoxal 5'-phosphate binding site [chemical binding]; other site
208435005143	homodimer interface [polypeptide binding]; other site
208435005144	catalytic residue [active]
208435005145	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
208435005146	Ligand Binding Site [chemical binding]; other site
208435005147	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
208435005148	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
208435005149	active site
208435005150	motif I; other site
208435005151	motif II; other site
208435005152	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
208435005153	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4696
208435005154	metal binding site [ion binding]; metal-binding site
208435005155	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
208435005156	active site
208435005157	homotetramer interface [polypeptide binding]; other site
208435005158	homodimer interface [polypeptide binding]; other site
208435005159	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
208435005160	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
208435005161	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
208435005162	shikimate binding site; other site
208435005163	NAD(P) binding site [chemical binding]; other site
208435005164	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
208435005165	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
208435005166	active site
208435005167	catalytic tetrad [active]
208435005168	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
208435005169	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
208435005170	generic binding surface II; other site
208435005171	ssDNA binding site; other site
208435005172	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
208435005173	ATP binding site [chemical binding]; other site
208435005174	putative Mg++ binding site [ion binding]; other site
208435005175	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
208435005176	nucleotide binding region [chemical binding]; other site
208435005177	ATP-binding site [chemical binding]; other site
208435005178	Surface antigen [General function prediction only]; Region: COG3942
208435005179	CHAP domain; Region: CHAP; pfam05257
208435005180	alanine racemase; Reviewed; Region: alr; PRK00053
208435005181	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
208435005182	active site
208435005183	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
208435005184	dimer interface [polypeptide binding]; other site
208435005185	substrate binding site [chemical binding]; other site
208435005186	catalytic residues [active]
208435005187	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
208435005188	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
208435005189	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
208435005190	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
208435005191	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
208435005192	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
208435005193	nucleotide binding region [chemical binding]; other site
208435005194	ATP-binding site [chemical binding]; other site
208435005195	SEC-C motif; Region: SEC-C; pfam02810
208435005196	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
208435005197	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
208435005198	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
208435005199	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
208435005200	nucleotide binding site [chemical binding]; other site
208435005201	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
208435005202	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
208435005203	active site turn [active]
208435005204	phosphorylation site [posttranslational modification]
208435005205	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
208435005206	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
208435005207	HPr interaction site; other site
208435005208	glycerol kinase (GK) interaction site [polypeptide binding]; other site
208435005209	active site
208435005210	phosphorylation site [posttranslational modification]
208435005211	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
208435005212	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
208435005213	substrate binding [chemical binding]; other site
208435005214	active site
208435005215	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
208435005216	Transcriptional regulators [Transcription]; Region: PurR; COG1609
208435005217	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
208435005218	DNA binding site [nucleotide binding]
208435005219	domain linker motif; other site
208435005220	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
208435005221	dimerization interface [polypeptide binding]; other site
208435005222	ligand binding site [chemical binding]; other site
208435005223	sodium binding site [ion binding]; other site
208435005224	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
208435005225	putative RNA binding site [nucleotide binding]; other site
208435005226	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
208435005227	elongation factor P; Validated; Region: PRK00529
208435005228	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
208435005229	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
208435005230	RNA binding site [nucleotide binding]; other site
208435005231	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
208435005232	RNA binding site [nucleotide binding]; other site
208435005233	Domain of unknown function (DUF4176); Region: DUF4176; pfam13780
208435005234	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
208435005235	catalytic motif [active]
208435005236	Zn binding site [ion binding]; other site
208435005237	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
208435005238	Major Facilitator Superfamily; Region: MFS_1; pfam07690
208435005239	putative substrate translocation pore; other site
208435005240	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
208435005241	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
208435005242	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
208435005243	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
208435005244	Protein of unknown function (DUF1129); Region: DUF1129; cl11555
208435005245	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
208435005246	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
208435005247	Cl binding site [ion binding]; other site
208435005248	oligomer interface [polypeptide binding]; other site
208435005249	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
208435005250	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
208435005251	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
208435005252	dimer interface [polypeptide binding]; other site
208435005253	ssDNA binding site [nucleotide binding]; other site
208435005254	tetramer (dimer of dimers) interface [polypeptide binding]; other site
208435005255	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
208435005256	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
208435005257	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
208435005258	minor groove reading motif; other site
208435005259	helix-hairpin-helix signature motif; other site
208435005260	substrate binding pocket [chemical binding]; other site
208435005261	active site
208435005262	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
208435005263	DNA binding and oxoG recognition site [nucleotide binding]
208435005264	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
208435005265	non-specific DNA binding site [nucleotide binding]; other site
208435005266	salt bridge; other site
208435005267	sequence-specific DNA binding site [nucleotide binding]; other site
208435005268	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
208435005269	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
208435005270	catalytic residues [active]
208435005271	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
208435005272	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
208435005273	active site
208435005274	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193
208435005275	MutS domain III; Region: MutS_III; pfam05192
208435005276	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
208435005277	Walker A/P-loop; other site
208435005278	ATP binding site [chemical binding]; other site
208435005279	Q-loop/lid; other site
208435005280	ABC transporter signature motif; other site
208435005281	Walker B; other site
208435005282	D-loop; other site
208435005283	H-loop/switch region; other site
208435005284	Smr domain; Region: Smr; pfam01713
208435005285	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
208435005286	Colicin V production protein; Region: Colicin_V; pfam02674
208435005287	ribonuclease HIII; Provisional; Region: PRK00996
208435005288	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
208435005289	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
208435005290	RNA/DNA hybrid binding site [nucleotide binding]; other site
208435005291	active site
208435005292	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
208435005293	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
208435005294	Catalytic site [active]
208435005295	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
208435005296	AAA domain; Region: AAA_30; pfam13604
208435005297	Family description; Region: UvrD_C_2; pfam13538
208435005298	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
208435005299	active site
208435005300	DNA polymerase IV; Validated; Region: PRK02406
208435005301	DNA binding site [nucleotide binding]
208435005302	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
208435005303	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
208435005304	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
208435005305	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
208435005306	Beta-lactamase; Region: Beta-lactamase; pfam00144
208435005307	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
208435005308	active site
208435005309	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
208435005310	amphipathic channel; other site
208435005311	Asn-Pro-Ala signature motifs; other site
208435005312	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
208435005313	Ligand Binding Site [chemical binding]; other site
208435005314	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
208435005315	Major Facilitator Superfamily; Region: MFS_1; pfam07690
208435005316	putative substrate translocation pore; other site
208435005317	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
208435005318	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
208435005319	x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371
208435005320	X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168
208435005321	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
208435005322	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
208435005323	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
208435005324	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
208435005325	substrate binding pocket [chemical binding]; other site
208435005326	chain length determination region; other site
208435005327	substrate-Mg2+ binding site; other site
208435005328	catalytic residues [active]
208435005329	aspartate-rich region 1; other site
208435005330	active site lid residues [active]
208435005331	aspartate-rich region 2; other site
208435005332	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
208435005333	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
208435005334	Walker A/P-loop; other site
208435005335	ATP binding site [chemical binding]; other site
208435005336	Q-loop/lid; other site
208435005337	ABC transporter signature motif; other site
208435005338	Walker B; other site
208435005339	D-loop; other site
208435005340	H-loop/switch region; other site
208435005341	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
208435005342	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
208435005343	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
208435005344	Walker A/P-loop; other site
208435005345	ATP binding site [chemical binding]; other site
208435005346	Q-loop/lid; other site
208435005347	ABC transporter signature motif; other site
208435005348	Walker B; other site
208435005349	D-loop; other site
208435005350	H-loop/switch region; other site
208435005351	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
208435005352	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
208435005353	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
208435005354	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
208435005355	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
208435005356	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
208435005357	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
208435005358	UbiA prenyltransferase family; Region: UbiA; pfam01040
208435005359	hypothetical protein; Validated; Region: PRK00153
208435005360	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
208435005361	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
208435005362	S-adenosylmethionine binding site [chemical binding]; other site
208435005363	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
208435005364	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
208435005365	DNA binding residues [nucleotide binding]
208435005366	dimer interface [polypeptide binding]; other site
208435005367	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
208435005368	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
208435005369	active site
208435005370	catalytic site [active]
208435005371	substrate binding site [chemical binding]; other site
208435005372	HI0933-like protein; Region: HI0933_like; pfam03486
208435005373	hydroxyglutarate oxidase; Provisional; Region: PRK11728
208435005374	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
208435005375	nucleotide binding site/active site [active]
208435005376	HIT family signature motif; other site
208435005377	catalytic residue [active]
208435005378	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
208435005379	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
208435005380	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
208435005381	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
208435005382	catalytic residue [active]
208435005383	UGMP family protein; Validated; Region: PRK09604
208435005384	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
208435005385	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
208435005386	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
208435005387	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
208435005388	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
208435005389	Coenzyme A binding pocket [chemical binding]; other site
208435005390	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
208435005391	Glycoprotease family; Region: Peptidase_M22; pfam00814
208435005392	hypothetical protein; Provisional; Region: PRK13667
208435005393	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
208435005394	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
208435005395	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
208435005396	CHAP domain; Region: CHAP; cl17642
208435005397	Surface antigen [General function prediction only]; Region: COG3942
208435005398	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
208435005399	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
208435005400	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
208435005401	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
208435005402	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
208435005403	DNA binding residues [nucleotide binding]
208435005404	putative dimer interface [polypeptide binding]; other site
208435005405	Predicted membrane protein [Function unknown]; Region: COG4129
208435005406	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
208435005407	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
208435005408	Phosphoglycerate kinase; Region: PGK; pfam00162
208435005409	substrate binding site [chemical binding]; other site
208435005410	hinge regions; other site
208435005411	ADP binding site [chemical binding]; other site
208435005412	catalytic site [active]
208435005413	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
208435005414	active site
208435005415	motif I; other site
208435005416	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
208435005417	motif II; other site
208435005418	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
208435005419	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
208435005420	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
208435005421	elongation factor G; Reviewed; Region: PRK00007
208435005422	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
208435005423	G1 box; other site
208435005424	putative GEF interaction site [polypeptide binding]; other site
208435005425	GTP/Mg2+ binding site [chemical binding]; other site
208435005426	Switch I region; other site
208435005427	G2 box; other site
208435005428	G3 box; other site
208435005429	Switch II region; other site
208435005430	G4 box; other site
208435005431	G5 box; other site
208435005432	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
208435005433	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
208435005434	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
208435005435	30S ribosomal protein S7; Validated; Region: PRK05302
208435005436	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
208435005437	S17 interaction site [polypeptide binding]; other site
208435005438	S8 interaction site; other site
208435005439	16S rRNA interaction site [nucleotide binding]; other site
208435005440	streptomycin interaction site [chemical binding]; other site
208435005441	23S rRNA interaction site [nucleotide binding]; other site
208435005442	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
208435005443	pur operon repressor; Provisional; Region: PRK09213
208435005444	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
208435005445	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
208435005446	active site
208435005447	Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481
208435005448	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
208435005449	generic binding surface II; other site
208435005450	generic binding surface I; other site
208435005451	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
208435005452	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
208435005453	Zn2+ binding site [ion binding]; other site
208435005454	Mg2+ binding site [ion binding]; other site
208435005455	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
208435005456	RmuC family; Region: RmuC; pfam02646
208435005457	Thiamine pyrophosphokinase; Region: TPK; cd07995
208435005458	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
208435005459	active site
208435005460	dimerization interface [polypeptide binding]; other site
208435005461	thiamine binding site [chemical binding]; other site
208435005462	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
208435005463	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
208435005464	substrate binding site [chemical binding]; other site
208435005465	hexamer interface [polypeptide binding]; other site
208435005466	metal binding site [ion binding]; metal-binding site
208435005467	GTPase RsgA; Reviewed; Region: PRK00098
208435005468	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
208435005469	RNA binding site [nucleotide binding]; other site
208435005470	homodimer interface [polypeptide binding]; other site
208435005471	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
208435005472	GTPase/Zn-binding domain interface [polypeptide binding]; other site
208435005473	GTP/Mg2+ binding site [chemical binding]; other site
208435005474	G4 box; other site
208435005475	G1 box; other site
208435005476	Switch I region; other site
208435005477	G2 box; other site
208435005478	G3 box; other site
208435005479	Switch II region; other site
208435005480	Methyltransferase domain; Region: Methyltransf_31; pfam13847
208435005481	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
208435005482	S-adenosylmethionine binding site [chemical binding]; other site
208435005483	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
208435005484	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
208435005485	S-adenosylmethionine binding site [chemical binding]; other site
208435005486	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
208435005487	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
208435005488	putative active site [active]
208435005489	putative metal binding site [ion binding]; other site
208435005490	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
208435005491	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
208435005492	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
208435005493	active site
208435005494	triacylglycerol lipase; Region: PLN00413
208435005495	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
208435005496	DltD N-terminal region; Region: DltD_N; pfam04915
208435005497	D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092
208435005498	DltD central region; Region: DltD_M; pfam04918
208435005499	DltD C-terminal region; Region: DltD_C; pfam04914
208435005500	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
208435005501	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
208435005502	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
208435005503	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
208435005504	acyl-activating enzyme (AAE) consensus motif; other site
208435005505	AMP binding site [chemical binding]; other site
208435005506	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
208435005507	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
208435005508	dimer interface [polypeptide binding]; other site
208435005509	phosphorylation site [posttranslational modification]
208435005510	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
208435005511	ATP binding site [chemical binding]; other site
208435005512	Mg2+ binding site [ion binding]; other site
208435005513	G-X-G motif; other site
208435005514	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
208435005515	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
208435005516	active site
208435005517	phosphorylation site [posttranslational modification]
208435005518	intermolecular recognition site; other site
208435005519	dimerization interface [polypeptide binding]; other site
208435005520	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
208435005521	DNA binding site [nucleotide binding]
208435005522	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
208435005523	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
208435005524	Nucleoside recognition; Region: Gate; pfam07670
208435005525	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
208435005526	Helix-turn-helix domain; Region: HTH_38; pfam13936
208435005527	Integrase core domain; Region: rve; pfam00665
208435005528	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
208435005529	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
208435005530	dimer interface [polypeptide binding]; other site
208435005531	conserved gate region; other site
208435005532	putative PBP binding loops; other site
208435005533	ABC-ATPase subunit interface; other site
208435005534	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
208435005535	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
208435005536	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
208435005537	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
208435005538	Walker A/P-loop; other site
208435005539	ATP binding site [chemical binding]; other site
208435005540	Q-loop/lid; other site
208435005541	ABC transporter signature motif; other site
208435005542	Walker B; other site
208435005543	D-loop; other site
208435005544	H-loop/switch region; other site
208435005545	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
208435005546	XFP N-terminal domain; Region: XFP_N; pfam09364
208435005547	putative phosphoketolase; Provisional; Region: PRK05261
208435005548	XFP C-terminal domain; Region: XFP_C; pfam09363
208435005549	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
208435005550	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
208435005551	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
208435005552	PRD domain; Region: PRD; pfam00874
208435005553	PRD domain; Region: PRD; pfam00874
208435005554	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
208435005555	active site
208435005556	P-loop; other site
208435005557	phosphorylation site [posttranslational modification]
208435005558	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
208435005559	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
208435005560	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
208435005561	putative N- and C-terminal domain interface [polypeptide binding]; other site
208435005562	putative active site [active]
208435005563	MgATP binding site [chemical binding]; other site
208435005564	catalytic site [active]
208435005565	metal binding site [ion binding]; metal-binding site
208435005566	putative xylulose binding site [chemical binding]; other site
208435005567	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
208435005568	Amidohydrolase; Region: Amidohydro_2; pfam04909
208435005569	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
208435005570	PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611
208435005571	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
208435005572	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178
208435005573	putative ligand binding site [chemical binding]; other site
208435005574	putative NAD binding site [chemical binding]; other site
208435005575	catalytic site [active]
208435005576	Transcriptional regulators [Transcription]; Region: PurR; COG1609
208435005577	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
208435005578	DNA binding site [nucleotide binding]
208435005579	domain linker motif; other site
208435005580	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
208435005581	putative dimerization interface [polypeptide binding]; other site
208435005582	putative ligand binding site [chemical binding]; other site
208435005583	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
208435005584	active site
208435005585	intersubunit interactions; other site
208435005586	catalytic residue [active]
208435005587	L-ribulose-5-phosphate 4-epimerase; Provisional; Region: araD; PRK13145
208435005588	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
208435005589	intersubunit interface [polypeptide binding]; other site
208435005590	active site
208435005591	Zn2+ binding site [ion binding]; other site
208435005592	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
208435005593	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
208435005594	AP (apurinic/apyrimidinic) site pocket; other site
208435005595	DNA interaction; other site
208435005596	Metal-binding active site; metal-binding site
208435005597	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
208435005598	active site
208435005599	dimer interface [polypeptide binding]; other site
208435005600	magnesium binding site [ion binding]; other site
208435005601	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
208435005602	active site
208435005603	phosphorylation site [posttranslational modification]
208435005604	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
208435005605	active site
208435005606	P-loop; other site
208435005607	phosphorylation site [posttranslational modification]
208435005608	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
208435005609	L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443
208435005610	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
208435005611	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
208435005612	GDP-binding site [chemical binding]; other site
208435005613	ACT binding site; other site
208435005614	IMP binding site; other site
208435005615	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
208435005616	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
208435005617	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
208435005618	YheO-like PAS domain; Region: PAS_6; pfam08348
208435005619	HTH domain; Region: HTH_22; pfam13309
208435005620	bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471
208435005621	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
208435005622	ATP-grasp domain; Region: ATP-grasp_4; cl17255
208435005623	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178
208435005624	Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853
208435005625	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
208435005626	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
208435005627	dimerization interface [polypeptide binding]; other site
208435005628	domain crossover interface; other site
208435005629	redox-dependent activation switch; other site
208435005630	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
208435005631	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
208435005632	FMN binding site [chemical binding]; other site
208435005633	active site
208435005634	catalytic residues [active]
208435005635	substrate binding site [chemical binding]; other site
208435005636	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
208435005637	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
208435005638	Substrate-binding site [chemical binding]; other site
208435005639	Substrate specificity [chemical binding]; other site
208435005640	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
208435005641	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
208435005642	Coenzyme A binding pocket [chemical binding]; other site
208435005643	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
208435005644	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
208435005645	Walker A motif; other site
208435005646	ATP binding site [chemical binding]; other site
208435005647	Walker B motif; other site
208435005648	arginine finger; other site
208435005649	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
208435005650	Walker A motif; other site
208435005651	ATP binding site [chemical binding]; other site
208435005652	Walker B motif; other site
208435005653	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
208435005654	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
208435005655	Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695
208435005656	elongation factor Ts; Provisional; Region: tsf; PRK09377
208435005657	UBA/TS-N domain; Region: UBA; pfam00627
208435005658	Elongation factor TS; Region: EF_TS; pfam00889
208435005659	Elongation factor TS; Region: EF_TS; pfam00889
208435005660	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
208435005661	rRNA interaction site [nucleotide binding]; other site
208435005662	S8 interaction site; other site
208435005663	putative laminin-1 binding site; other site
208435005664	peroxiredoxin; Region: AhpC; TIGR03137
208435005665	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
208435005666	dimer interface [polypeptide binding]; other site
208435005667	decamer (pentamer of dimers) interface [polypeptide binding]; other site
208435005668	catalytic triad [active]
208435005669	peroxidatic and resolving cysteines [active]
208435005670	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
208435005671	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
208435005672	catalytic residue [active]
208435005673	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
208435005674	catalytic residues [active]
208435005675	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
208435005676	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
208435005677	lysogenic prophage LambdaSa2 region; nonfunctional prophage
208435005678	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
208435005679	YcfA-like protein; Region: YcfA; pfam07927
208435005680	Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382
208435005681	Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; smart01095
208435005682	Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; smart01095
208435005683	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
208435005684	Phage holin protein (Holin_LLH); Region: Holin_LLH; pfam09682
208435005685	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
208435005686	Phage-related protein [Function unknown]; Region: COG4722
208435005687	Phage-related minor tail protein [Function unknown]; Region: COG5280
208435005688	Lactococcus lactis bacteriophage major structural protein; Region: L_lac_phage_MSP; pfam06488
208435005689	Phage capsid family; Region: Phage_capsid; pfam05065
208435005690	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
208435005691	Phage portal protein; Region: Phage_portal; pfam04860
208435005692	Phage-related protein [Function unknown]; Region: COG4695; cl01923
208435005693	Phage Terminase; Region: Terminase_1; pfam03354
208435005694	INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186
208435005695	Int/Topo IB signature motif; other site
208435005696	phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636
208435005697	Protein of unknown function (DUF722); Region: DUF722; pfam05263
208435005698	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
208435005699	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
208435005700	non-specific DNA binding site [nucleotide binding]; other site
208435005701	salt bridge; other site
208435005702	sequence-specific DNA binding site [nucleotide binding]; other site
208435005703	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
208435005704	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
208435005705	dimer interface [polypeptide binding]; other site
208435005706	ssDNA binding site [nucleotide binding]; other site
208435005707	tetramer (dimer of dimers) interface [polypeptide binding]; other site
208435005708	Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753
208435005709	Protein of unknown function (DUF1372); Region: DUF1372; pfam07116
208435005710	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u3; cd11540
208435005711	putative metal binding site [ion binding]; other site
208435005712	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
208435005713	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
208435005714	cofactor binding site; other site
208435005715	DNA binding site [nucleotide binding]
208435005716	substrate interaction site [chemical binding]; other site
208435005717	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
208435005718	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
208435005719	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
208435005720	Walker A motif; other site
208435005721	ATP binding site [chemical binding]; other site
208435005722	Walker B motif; other site
208435005723	replicative DNA helicase; Provisional; Region: PRK05748
208435005724	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
208435005725	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
208435005726	Walker A motif; other site
208435005727	ATP binding site [chemical binding]; other site
208435005728	Walker B motif; other site
208435005729	DNA binding loops [nucleotide binding]
208435005730	NUMOD4 motif; Region: NUMOD4; pfam07463
208435005731	HNH endonuclease; Region: HNH_3; pfam13392
208435005732	NUMOD1 domain; Region: NUMOD1; pfam07453
208435005733	Prophage antirepressor [Transcription]; Region: COG3617
208435005734	BRO family, N-terminal domain; Region: Bro-N; smart01040
208435005735	ORF6C domain; Region: ORF6C; pfam10552
208435005736	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
208435005737	non-specific DNA binding site [nucleotide binding]; other site
208435005738	salt bridge; other site
208435005739	sequence-specific DNA binding site [nucleotide binding]; other site
208435005740	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
208435005741	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
208435005742	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
208435005743	non-specific DNA binding site [nucleotide binding]; other site
208435005744	salt bridge; other site
208435005745	sequence-specific DNA binding site [nucleotide binding]; other site
208435005746	Domain of unknown function (DUF955); Region: DUF955; pfam06114
208435005747	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
208435005748	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
208435005749	Int/Topo IB signature motif; other site
208435005750	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
208435005751	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
208435005752	putative dimer interface [polypeptide binding]; other site
208435005753	catalytic triad [active]
208435005754	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
208435005755	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
208435005756	active site
208435005757	Zn binding site [ion binding]; other site
208435005758	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
208435005759	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
208435005760	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
208435005761	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
208435005762	putative substrate translocation pore; other site
208435005763	Major Facilitator Superfamily; Region: MFS_1; pfam07690
208435005764	DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402
208435005765	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
208435005766	ligand binding site [chemical binding]; other site
208435005767	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
208435005768	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
208435005769	active site
208435005770	catalytic residues [active]
208435005771	metal binding site [ion binding]; metal-binding site
208435005772	Transcriptional regulators [Transcription]; Region: PurR; COG1609
208435005773	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
208435005774	DNA binding site [nucleotide binding]
208435005775	domain linker motif; other site
208435005776	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
208435005777	putative dimerization interface [polypeptide binding]; other site
208435005778	putative ligand binding site [chemical binding]; other site
208435005779	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
208435005780	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
208435005781	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
208435005782	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
208435005783	active site
208435005784	phosphorylation site [posttranslational modification]
208435005785	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
208435005786	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
208435005787	active pocket/dimerization site; other site
208435005788	active site
208435005789	phosphorylation site [posttranslational modification]
208435005790	gluconate 5-dehydrogenase; Provisional; Region: PRK07097
208435005791	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
208435005792	NADP binding site [chemical binding]; other site
208435005793	homodimer interface [polypeptide binding]; other site
208435005794	active site
208435005795	hypothetical protein; Provisional; Region: PRK09273
208435005796	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
208435005797	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
208435005798	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
208435005799	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
208435005800	substrate binding site [chemical binding]; other site
208435005801	ATP binding site [chemical binding]; other site
208435005802	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
208435005803	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
208435005804	active site
208435005805	intersubunit interface [polypeptide binding]; other site
208435005806	catalytic residue [active]
208435005807	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
208435005808	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
208435005809	dimer interface [polypeptide binding]; other site
208435005810	FMN binding site [chemical binding]; other site
208435005811	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
208435005812	MarR family; Region: MarR; pfam01047
208435005813	MarR family; Region: MarR_2; cl17246
208435005814	DNA polymerase III PolC; Validated; Region: polC; PRK00448
208435005815	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
208435005816	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
208435005817	generic binding surface II; other site
208435005818	generic binding surface I; other site
208435005819	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
208435005820	active site
208435005821	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
208435005822	active site
208435005823	catalytic site [active]
208435005824	substrate binding site [chemical binding]; other site
208435005825	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
208435005826	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
208435005827	prolyl-tRNA synthetase; Provisional; Region: PRK09194
208435005828	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
208435005829	motif 1; other site
208435005830	dimer interface [polypeptide binding]; other site
208435005831	active site
208435005832	motif 2; other site
208435005833	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
208435005834	putative deacylase active site [active]
208435005835	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
208435005836	active site
208435005837	motif 3; other site
208435005838	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
208435005839	anticodon binding site; other site
208435005840	RIP metalloprotease RseP; Region: TIGR00054
208435005841	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
208435005842	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
208435005843	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
208435005844	protein binding site [polypeptide binding]; other site
208435005845	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
208435005846	putative substrate binding region [chemical binding]; other site
208435005847	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
208435005848	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
208435005849	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
208435005850	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
208435005851	catalytic residue [active]
208435005852	putative FPP diphosphate  binding site; other site
208435005853	putative FPP binding hydrophobic cleft; other site
208435005854	dimer interface [polypeptide binding]; other site
208435005855	putative IPP diphosphate binding site; other site
208435005856	preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531
208435005857	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
208435005858	catalytic residues [active]
208435005859	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
208435005860	Malic enzyme, N-terminal domain; Region: malic; pfam00390
208435005861	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
208435005862	putative NAD(P) binding site [chemical binding]; other site
208435005863	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
208435005864	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
208435005865	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
208435005866	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
208435005867	active site
208435005868	phosphorylation site [posttranslational modification]
208435005869	intermolecular recognition site; other site
208435005870	dimerization interface [polypeptide binding]; other site
208435005871	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
208435005872	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
208435005873	NAD binding site [chemical binding]; other site
208435005874	homodimer interface [polypeptide binding]; other site
208435005875	active site
208435005876	substrate binding site [chemical binding]; other site
208435005877	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
208435005878	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
208435005879	Ca binding site [ion binding]; other site
208435005880	active site
208435005881	catalytic site [active]
208435005882	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
208435005883	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
208435005884	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
208435005885	Walker A/P-loop; other site
208435005886	ATP binding site [chemical binding]; other site
208435005887	Q-loop/lid; other site
208435005888	ABC transporter signature motif; other site
208435005889	Walker B; other site
208435005890	D-loop; other site
208435005891	H-loop/switch region; other site
208435005892	TOBE domain; Region: TOBE_2; pfam08402
208435005893	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
208435005894	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
208435005895	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
208435005896	active site
208435005897	catalytic residues [active]
208435005898	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
208435005899	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
208435005900	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
208435005901	putative substrate binding site [chemical binding]; other site
208435005902	putative ATP binding site [chemical binding]; other site
208435005903	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
208435005904	galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621
208435005905	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
208435005906	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
208435005907	Asp-box motif; other site
208435005908	Asp-box motif; other site
208435005909	catalytic site [active]
208435005910	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
208435005911	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
208435005912	Phosphotransferase system, galactitol-specific IIB component [Carbohydrate transport and metabolism]; Region: SgaB; COG3414
208435005913	active site
208435005914	P-loop; other site
208435005915	phosphorylation site [posttranslational modification]
208435005916	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
208435005917	active site
208435005918	phosphorylation site [posttranslational modification]
208435005919	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
208435005920	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
208435005921	DNA-binding site [nucleotide binding]; DNA binding site
208435005922	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
208435005923	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
208435005924	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
208435005925	intersubunit interface [polypeptide binding]; other site
208435005926	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
208435005927	putative active site [active]
208435005928	dimerization interface [polypeptide binding]; other site
208435005929	putative tRNAtyr binding site [nucleotide binding]; other site
208435005930	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
208435005931	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
208435005932	Zn2+ binding site [ion binding]; other site
208435005933	Mg2+ binding site [ion binding]; other site
208435005934	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
208435005935	synthetase active site [active]
208435005936	NTP binding site [chemical binding]; other site
208435005937	metal binding site [ion binding]; metal-binding site
208435005938	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
208435005939	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
208435005940	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK11907
208435005941	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
208435005942	active site
208435005943	metal binding site [ion binding]; metal-binding site
208435005944	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
208435005945	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
208435005946	flavoprotein NrdI; Provisional; Region: PRK02551
208435005947	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
208435005948	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
208435005949	putative oligomer interface [polypeptide binding]; other site
208435005950	putative active site [active]
208435005951	metal binding site [ion binding]; metal-binding site
208435005952	AAA domain; Region: AAA_33; pfam13671
208435005953	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019
208435005954	active site
208435005955	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
208435005956	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
208435005957	Response regulator receiver domain; Region: Response_reg; pfam00072
208435005958	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
208435005959	active site
208435005960	phosphorylation site [posttranslational modification]
208435005961	intermolecular recognition site; other site
208435005962	dimerization interface [polypeptide binding]; other site
208435005963	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
208435005964	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
208435005965	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
208435005966	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
208435005967	Histidine kinase; Region: His_kinase; pfam06580
208435005968	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
208435005969	ATP binding site [chemical binding]; other site
208435005970	Mg2+ binding site [ion binding]; other site
208435005971	G-X-G motif; other site
208435005972	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
208435005973	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
208435005974	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
208435005975	active site
208435005976	phosphorylation site [posttranslational modification]
208435005977	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
208435005978	active pocket/dimerization site; other site
208435005979	active site
208435005980	phosphorylation site [posttranslational modification]
208435005981	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
208435005982	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
208435005983	ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264
208435005984	Walker A/P-loop; other site
208435005985	ATP binding site [chemical binding]; other site
208435005986	Q-loop/lid; other site
208435005987	ABC transporter signature motif; other site
208435005988	Walker B; other site
208435005989	D-loop; other site
208435005990	H-loop/switch region; other site
208435005991	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
208435005992	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
208435005993	active site
208435005994	phosphorylation site [posttranslational modification]
208435005995	intermolecular recognition site; other site
208435005996	dimerization interface [polypeptide binding]; other site
208435005997	LytTr DNA-binding domain; Region: LytTR; pfam04397
208435005998	Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079
208435005999	putative catalytic site [active]
208435006000	putative metal binding site [ion binding]; other site
208435006001	putative phosphate binding site [ion binding]; other site
208435006002	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
208435006003	PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003
208435006004	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
208435006005	active site turn [active]
208435006006	phosphorylation site [posttranslational modification]
208435006007	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
208435006008	HPr interaction site; other site
208435006009	glycerol kinase (GK) interaction site [polypeptide binding]; other site
208435006010	active site
208435006011	phosphorylation site [posttranslational modification]
208435006012	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
208435006013	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
208435006014	dimer interface [polypeptide binding]; other site
208435006015	phosphorylation site [posttranslational modification]
208435006016	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
208435006017	ATP binding site [chemical binding]; other site
208435006018	Mg2+ binding site [ion binding]; other site
208435006019	G-X-G motif; other site
208435006020	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
208435006021	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
208435006022	active site
208435006023	phosphorylation site [posttranslational modification]
208435006024	intermolecular recognition site; other site
208435006025	dimerization interface [polypeptide binding]; other site
208435006026	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
208435006027	DNA binding site [nucleotide binding]
208435006028	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
208435006029	PhoU domain; Region: PhoU; pfam01895
208435006030	PhoU domain; Region: PhoU; pfam01895
208435006031	phosphate transporter ATP-binding protein; Provisional; Region: PRK14240
208435006032	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
208435006033	Walker A/P-loop; other site
208435006034	ATP binding site [chemical binding]; other site
208435006035	Q-loop/lid; other site
208435006036	ABC transporter signature motif; other site
208435006037	Walker B; other site
208435006038	D-loop; other site
208435006039	H-loop/switch region; other site
208435006040	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
208435006041	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
208435006042	dimer interface [polypeptide binding]; other site
208435006043	conserved gate region; other site
208435006044	putative PBP binding loops; other site
208435006045	ABC-ATPase subunit interface; other site
208435006046	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
208435006047	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
208435006048	dimer interface [polypeptide binding]; other site
208435006049	conserved gate region; other site
208435006050	putative PBP binding loops; other site
208435006051	ABC-ATPase subunit interface; other site
208435006052	PBP superfamily domain; Region: PBP_like_2; cl17296
208435006053	PBP superfamily domain; Region: PBP_like_2; cl17296
208435006054	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
208435006055	active site
208435006056	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
208435006057	RNA methyltransferase, RsmE family; Region: TIGR00046
208435006058	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
208435006059	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
208435006060	S-adenosylmethionine binding site [chemical binding]; other site
208435006061	MepB protein; Region: MepB; cl01985
208435006062	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
208435006063	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
208435006064	DNA binding residues [nucleotide binding]
208435006065	dimer interface [polypeptide binding]; other site
208435006066	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
208435006067	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
208435006068	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
208435006069	Coenzyme A binding pocket [chemical binding]; other site
208435006070	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682
208435006071	nudix motif; other site
208435006072	ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020
208435006073	Protein of unknown function (DUF3013); Region: DUF3013; pfam11217
208435006074	putative acetyltransferase; Provisional; Region: PRK03624
208435006075	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
208435006076	recombination factor protein RarA; Reviewed; Region: PRK13342
208435006077	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
208435006078	Walker A motif; other site
208435006079	ATP binding site [chemical binding]; other site
208435006080	Walker B motif; other site
208435006081	arginine finger; other site
208435006082	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
208435006083	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
208435006084	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
208435006085	Walker A/P-loop; other site
208435006086	ATP binding site [chemical binding]; other site
208435006087	Q-loop/lid; other site
208435006088	ABC transporter signature motif; other site
208435006089	Walker B; other site
208435006090	D-loop; other site
208435006091	H-loop/switch region; other site
208435006092	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
208435006093	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
208435006094	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
208435006095	non-specific DNA binding site [nucleotide binding]; other site
208435006096	salt bridge; other site
208435006097	sequence-specific DNA binding site [nucleotide binding]; other site
208435006098	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523
208435006099	metal binding site [ion binding]; metal-binding site
208435006100	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
208435006101	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
208435006102	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
208435006103	Int/Topo IB signature motif; other site
208435006104	Domain of unknown function (DUF3173); Region: DUF3173; pfam11372
208435006105	Replication initiation factor; Region: Rep_trans; pfam02486
208435006106	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
208435006107	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
208435006108	non-specific DNA binding site [nucleotide binding]; other site
208435006109	salt bridge; other site
208435006110	sequence-specific DNA binding site [nucleotide binding]; other site
208435006111	Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406
208435006112	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
208435006113	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
208435006114	Int/Topo IB signature motif; other site
208435006115	Domain of unknown function (DUF771); Region: DUF771; pfam05595
208435006116	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
208435006117	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
208435006118	AAA-like domain; Region: AAA_10; pfam12846
208435006119	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
208435006120	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
208435006121	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
208435006122	TcpE family; Region: TcpE; pfam12648
208435006123	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
208435006124	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
208435006125	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
208435006126	Antirestriction protein (ArdA); Region: ArdA; cl01953
208435006127	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
208435006128	AAA domain; Region: AAA_23; pfam13476
208435006129	Walker A/P-loop; other site
208435006130	ATP binding site [chemical binding]; other site
208435006131	AAA domain; Region: AAA_21; pfam13304
208435006132	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
208435006133	sequence-specific DNA binding site [nucleotide binding]; other site
208435006134	salt bridge; other site
208435006135	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
208435006136	non-specific DNA binding site [nucleotide binding]; other site
208435006137	salt bridge; other site
208435006138	sequence-specific DNA binding site [nucleotide binding]; other site
208435006139	Replication initiation factor; Region: Rep_trans; pfam02486
208435006140	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
208435006141	TolA protein; Region: tolA_full; TIGR02794
208435006142	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
208435006143	adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228
208435006144	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
208435006145	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
208435006146	Transposase; Region: DDE_Tnp_ISL3; pfam01610
208435006147	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
208435006148	metal-binding site [ion binding]
208435006149	mercuric reductase; Region: MerA; TIGR02053
208435006150	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
208435006151	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
208435006152	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
208435006153	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
208435006154	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
208435006155	DNA binding residues [nucleotide binding]
208435006156	dimer interface [polypeptide binding]; other site
208435006157	mercury binding site [ion binding]; other site
208435006158	manganese transport protein MntH; Reviewed; Region: PRK00701
208435006159	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
208435006160	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
208435006161	Walker A/P-loop; other site
208435006162	ATP binding site [chemical binding]; other site
208435006163	Q-loop/lid; other site
208435006164	ABC transporter signature motif; other site
208435006165	Walker B; other site
208435006166	D-loop; other site
208435006167	exported signaling peptide, YydF/SAG_2028 family; Region: expor_sig_YdyF; TIGR04077
208435006168	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
208435006169	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
208435006170	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
208435006171	Predicted transcriptional regulators [Transcription]; Region: COG1695
208435006172	Transcriptional regulator PadR-like family; Region: PadR; cl17335
208435006173	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
208435006174	Coenzyme A binding pocket [chemical binding]; other site
208435006175	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
208435006176	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
208435006177	Walker A/P-loop; other site
208435006178	ATP binding site [chemical binding]; other site
208435006179	Q-loop/lid; other site
208435006180	ABC transporter signature motif; other site
208435006181	Walker B; other site
208435006182	D-loop; other site
208435006183	H-loop/switch region; other site
208435006184	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
208435006185	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
208435006186	non-specific DNA binding site [nucleotide binding]; other site
208435006187	salt bridge; other site
208435006188	sequence-specific DNA binding site [nucleotide binding]; other site
208435006189	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
208435006190	active site
208435006191	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523
208435006192	metal binding site [ion binding]; metal-binding site
208435006193	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
208435006194	CAAX protease self-immunity; Region: Abi; pfam02517
208435006195	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
208435006196	active site residue [active]
208435006197	CAMP factor (Cfa); Region: CAMP_factor; pfam07373
208435006198	topology modulation protein; Provisional; Region: PRK07261
208435006199	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019
208435006200	active site
208435006201	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
208435006202	Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171
208435006203	putative active site [active]
208435006204	metal binding site [ion binding]; metal-binding site
208435006205	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
208435006206	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
208435006207	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
208435006208	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
208435006209	FAD binding site [chemical binding]; other site
208435006210	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
208435006211	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
208435006212	THF binding site; other site
208435006213	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
208435006214	substrate binding site [chemical binding]; other site
208435006215	THF binding site; other site
208435006216	zinc-binding site [ion binding]; other site
208435006217	Predicted membrane protein [Function unknown]; Region: COG4392
208435006218	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
208435006219	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
208435006220	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
208435006221	putative active site [active]
208435006222	catalytic triad [active]
208435006223	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
208435006224	putative integrin binding motif; other site
208435006225	PA/protease domain interface [polypeptide binding]; other site
208435006226	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
208435006227	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
208435006228	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
208435006229	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
208435006230	active site
208435006231	phosphorylation site [posttranslational modification]
208435006232	intermolecular recognition site; other site
208435006233	dimerization interface [polypeptide binding]; other site
208435006234	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
208435006235	DNA binding site [nucleotide binding]
208435006236	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
208435006237	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
208435006238	dimer interface [polypeptide binding]; other site
208435006239	phosphorylation site [posttranslational modification]
208435006240	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
208435006241	ATP binding site [chemical binding]; other site
208435006242	Mg2+ binding site [ion binding]; other site
208435006243	G-X-G motif; other site
208435006244	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
208435006245	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
208435006246	HIGH motif; other site
208435006247	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
208435006248	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
208435006249	active site
208435006250	KMSKS motif; other site
208435006251	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
208435006252	tRNA binding surface [nucleotide binding]; other site
208435006253	benzoate transport; Region: 2A0115; TIGR00895
208435006254	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
208435006255	putative substrate translocation pore; other site
208435006256	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
208435006257	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
208435006258	active site
208435006259	nucleophile elbow; other site
208435006260	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
208435006261	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
208435006262	Ligand binding site; other site
208435006263	metal-binding site
208435006264	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
208435006265	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
208435006266	Ligand binding site; other site
208435006267	metal-binding site
208435006268	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
208435006269	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
208435006270	putative homodimer interface [polypeptide binding]; other site
208435006271	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
208435006272	heterodimer interface [polypeptide binding]; other site
208435006273	homodimer interface [polypeptide binding]; other site
208435006274	YSIRK type signal peptide; Region: YSIRK_signal; cl04650
208435006275	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
208435006276	Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690
208435006277	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
208435006278	Transglycosylase; Region: Transgly; pfam00912
208435006279	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
208435006280	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
208435006281	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
208435006282	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
208435006283	active site
208435006284	Predicted membrane protein [Function unknown]; Region: COG4640
208435006285	phosphopentomutase; Provisional; Region: PRK05362
208435006286	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
208435006287	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
208435006288	intersubunit interface [polypeptide binding]; other site
208435006289	active site
208435006290	catalytic residue [active]
208435006291	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
208435006292	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
208435006293	Nucleoside recognition; Region: Gate; pfam07670
208435006294	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
208435006295	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
208435006296	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
208435006297	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
208435006298	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
208435006299	DNA-binding site [nucleotide binding]; DNA binding site
208435006300	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
208435006301	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
208435006302	ring oligomerisation interface [polypeptide binding]; other site
208435006303	ATP/Mg binding site [chemical binding]; other site
208435006304	stacking interactions; other site
208435006305	hinge regions; other site
208435006306	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
208435006307	oligomerisation interface [polypeptide binding]; other site
208435006308	mobile loop; other site
208435006309	roof hairpin; other site
208435006310	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
208435006311	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
208435006312	Walker A/P-loop; other site
208435006313	ATP binding site [chemical binding]; other site
208435006314	Q-loop/lid; other site
208435006315	ABC transporter signature motif; other site
208435006316	Walker B; other site
208435006317	D-loop; other site
208435006318	H-loop/switch region; other site
208435006319	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
208435006320	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
208435006321	TM-ABC transporter signature motif; other site
208435006322	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
208435006323	zinc binding site [ion binding]; other site
208435006324	putative ligand binding site [chemical binding]; other site
208435006325	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
208435006326	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
208435006327	active site
208435006328	motif I; other site
208435006329	motif II; other site
208435006330	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
208435006331	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
208435006332	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
208435006333	putative metal binding site [ion binding]; other site
208435006334	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
208435006335	hypothetical protein; Validated; Region: PRK02101
208435006336	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
208435006337	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
208435006338	FeS/SAM binding site; other site
208435006339	Predicted acetyltransferase [General function prediction only]; Region: COG3981
208435006340	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
208435006341	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
208435006342	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
208435006343	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
208435006344	ATP cone domain; Region: ATP-cone; pfam03477
208435006345	Class III ribonucleotide reductase; Region: RNR_III; cd01675
208435006346	effector binding site; other site
208435006347	active site
208435006348	Zn binding site [ion binding]; other site
208435006349	glycine loop; other site
208435006350	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
208435006351	hypothetical protein; Provisional; Region: PRK13678
208435006352	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
208435006353	hypothetical protein; Provisional; Region: PRK05473
208435006354	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
208435006355	ArsC family; Region: ArsC; pfam03960
208435006356	putative catalytic residues [active]
208435006357	thiol/disulfide switch; other site
208435006358	recombinase A; Provisional; Region: recA; PRK09354
208435006359	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
208435006360	hexamer interface [polypeptide binding]; other site
208435006361	Walker A motif; other site
208435006362	ATP binding site [chemical binding]; other site
208435006363	Walker B motif; other site
208435006364	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
208435006365	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
208435006366	RuvA N terminal domain; Region: RuvA_N; pfam01330
208435006367	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
208435006368	Major Facilitator Superfamily; Region: MFS_1; pfam07690
208435006369	putative substrate translocation pore; other site
208435006370	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
208435006371	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
208435006372	ATP binding site [chemical binding]; other site
208435006373	Mg2+ binding site [ion binding]; other site
208435006374	G-X-G motif; other site
208435006375	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
208435006376	ATP binding site [chemical binding]; other site
208435006377	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
208435006378	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
208435006379	DNA-binding site [nucleotide binding]; DNA binding site
208435006380	RNA-binding motif; other site
208435006381	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
208435006382	MutS domain I; Region: MutS_I; pfam01624
208435006383	MutS domain II; Region: MutS_II; pfam05188
208435006384	MutS domain III; Region: MutS_III; pfam05192
208435006385	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
208435006386	Walker A/P-loop; other site
208435006387	ATP binding site [chemical binding]; other site
208435006388	Q-loop/lid; other site
208435006389	ABC transporter signature motif; other site
208435006390	Walker B; other site
208435006391	D-loop; other site
208435006392	H-loop/switch region; other site
208435006393	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
208435006394	arginine repressor; Region: argR_whole; TIGR01529
208435006395	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
208435006396	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
208435006397	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
208435006398	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
208435006399	active site
208435006400	HIGH motif; other site
208435006401	KMSK motif region; other site
208435006402	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
208435006403	tRNA binding surface [nucleotide binding]; other site
208435006404	anticodon binding site; other site
208435006405	Enterocin A Immunity; Region: EntA_Immun; pfam08951
208435006406	Uncharacterized conserved protein [Function unknown]; Region: COG1284
208435006407	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
208435006408	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
208435006409	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
208435006410	Uncharacterized conserved protein [Function unknown]; Region: COG1284
208435006411	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
208435006412	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
208435006413	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
208435006414	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
208435006415	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
208435006416	dimer interface [polypeptide binding]; other site
208435006417	anticodon binding site; other site
208435006418	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
208435006419	homodimer interface [polypeptide binding]; other site
208435006420	motif 1; other site
208435006421	active site
208435006422	motif 2; other site
208435006423	GAD domain; Region: GAD; pfam02938
208435006424	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
208435006425	motif 3; other site
208435006426	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
208435006427	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
208435006428	dimer interface [polypeptide binding]; other site
208435006429	motif 1; other site
208435006430	active site
208435006431	motif 2; other site
208435006432	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
208435006433	anticodon binding site; other site
208435006434	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
208435006435	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
208435006436	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
208435006437	Gypsy protein; Region: Gypsy; pfam07253
208435006438	Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199
208435006439	Int/Topo IB signature motif; other site
208435006440	Replication initiation factor; Region: Rep_trans; pfam02486
208435006441	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
208435006442	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
208435006443	non-specific DNA binding site [nucleotide binding]; other site
208435006444	salt bridge; other site
208435006445	sequence-specific DNA binding site [nucleotide binding]; other site
208435006446	Fic family protein [Function unknown]; Region: COG3177
208435006447	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
208435006448	Fic/DOC family; Region: Fic; pfam02661
208435006449	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
208435006450	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
208435006451	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
208435006452	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
208435006453	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
208435006454	active site
208435006455	phosphorylation site [posttranslational modification]
208435006456	intermolecular recognition site; other site
208435006457	dimerization interface [polypeptide binding]; other site
208435006458	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
208435006459	DNA binding site [nucleotide binding]
208435006460	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
208435006461	HAMP domain; Region: HAMP; pfam00672
208435006462	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
208435006463	dimer interface [polypeptide binding]; other site
208435006464	phosphorylation site [posttranslational modification]
208435006465	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
208435006466	ATP binding site [chemical binding]; other site
208435006467	Mg2+ binding site [ion binding]; other site
208435006468	G-X-G motif; other site
208435006469	Predicted membrane protein [Function unknown]; Region: COG1288
208435006470	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
208435006471	carbamate kinase; Reviewed; Region: PRK12686
208435006472	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
208435006473	putative substrate binding site [chemical binding]; other site
208435006474	nucleotide binding site [chemical binding]; other site
208435006475	nucleotide binding site [chemical binding]; other site
208435006476	homodimer interface [polypeptide binding]; other site
208435006477	ornithine carbamoyltransferase; Provisional; Region: PRK04284
208435006478	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
208435006479	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
208435006480	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
208435006481	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
208435006482	ATP binding site [chemical binding]; other site
208435006483	Mg2+ binding site [ion binding]; other site
208435006484	G-X-G motif; other site
208435006485	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
208435006486	Response regulator receiver domain; Region: Response_reg; pfam00072
208435006487	active site
208435006488	phosphorylation site [posttranslational modification]
208435006489	intermolecular recognition site; other site
208435006490	dimerization interface [polypeptide binding]; other site
208435006491	YcbB domain; Region: YcbB; pfam08664
208435006492	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
208435006493	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
208435006494	Walker A/P-loop; other site
208435006495	ATP binding site [chemical binding]; other site
208435006496	Q-loop/lid; other site
208435006497	ABC transporter signature motif; other site
208435006498	Walker B; other site
208435006499	D-loop; other site
208435006500	H-loop/switch region; other site
208435006501	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
208435006502	dimer interface [polypeptide binding]; other site
208435006503	conserved gate region; other site
208435006504	ABC-ATPase subunit interface; other site
208435006505	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
208435006506	Predicted integral membrane protein [Function unknown]; Region: COG0392
208435006507	Uncharacterized conserved protein [Function unknown]; Region: COG2898
208435006508	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
208435006509	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
208435006510	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
208435006511	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
208435006512	Predicted membrane protein [Function unknown]; Region: COG1511
208435006513	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
208435006514	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
208435006515	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
208435006516	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
208435006517	Domain of unknown function (DUF4298); Region: DUF4298; pfam14131
208435006518	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
208435006519	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
208435006520	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
208435006521	RNA binding surface [nucleotide binding]; other site
208435006522	Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466
208435006523	replicative DNA helicase; Provisional; Region: PRK05748
208435006524	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
208435006525	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
208435006526	Walker A motif; other site
208435006527	ATP binding site [chemical binding]; other site
208435006528	Walker B motif; other site
208435006529	DNA binding loops [nucleotide binding]
208435006530	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
208435006531	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
208435006532	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
208435006533	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
208435006534	DHH family; Region: DHH; pfam01368
208435006535	DHHA1 domain; Region: DHHA1; pfam02272
208435006536	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
208435006537	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
208435006538	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
208435006539	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
208435006540	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
208435006541	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
208435006542	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
208435006543	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
208435006544	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
208435006545	putative L-serine binding site [chemical binding]; other site
208435006546	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
208435006547	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
208435006548	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
208435006549	N-acetyl-D-glucosamine binding site [chemical binding]; other site
208435006550	catalytic residue [active]
208435006551	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
208435006552	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
208435006553	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649
208435006554	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
208435006555	Walker A/P-loop; other site
208435006556	ATP binding site [chemical binding]; other site
208435006557	Q-loop/lid; other site
208435006558	ABC transporter signature motif; other site
208435006559	Walker B; other site
208435006560	D-loop; other site
208435006561	H-loop/switch region; other site
208435006562	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650
208435006563	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
208435006564	Walker A/P-loop; other site
208435006565	ATP binding site [chemical binding]; other site
208435006566	Q-loop/lid; other site
208435006567	ABC transporter signature motif; other site
208435006568	Walker B; other site
208435006569	D-loop; other site
208435006570	H-loop/switch region; other site
208435006571	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
208435006572	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
208435006573	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
208435006574	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
208435006575	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
208435006576	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
208435006577	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
208435006578	RNA binding surface [nucleotide binding]; other site
208435006579	recombination protein F; Reviewed; Region: recF; PRK00064
208435006580	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
208435006581	Walker A/P-loop; other site
208435006582	ATP binding site [chemical binding]; other site
208435006583	Q-loop/lid; other site
208435006584	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
208435006585	ABC transporter signature motif; other site
208435006586	Walker B; other site
208435006587	D-loop; other site
208435006588	H-loop/switch region; other site
208435006589	Sugar transport protein; Region: Sugar_transport; pfam06800
208435006590	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
208435006591	non-specific DNA binding site [nucleotide binding]; other site
208435006592	salt bridge; other site
208435006593	sequence-specific DNA binding site [nucleotide binding]; other site
208435006594	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
208435006595	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
208435006596	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
208435006597	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
208435006598	active site
208435006599	Arginine repressor [Transcription]; Region: ArgR; COG1438
208435006600	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
208435006601	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
208435006602	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
208435006603	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
208435006604	ligand binding site [chemical binding]; other site
208435006605	flexible hinge region; other site
208435006606	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
208435006607	non-specific DNA interactions [nucleotide binding]; other site
208435006608	DNA binding site [nucleotide binding]
208435006609	sequence specific DNA binding site [nucleotide binding]; other site
208435006610	putative cAMP binding site [chemical binding]; other site
208435006611	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
208435006612	B3/4 domain; Region: B3_4; pfam03483
208435006613	arginine deiminase; Provisional; Region: PRK01388
208435006614	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
208435006615	Coenzyme A binding pocket [chemical binding]; other site
208435006616	ornithine carbamoyltransferase; Validated; Region: PRK02102
208435006617	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
208435006618	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
208435006619	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
208435006620	carbamate kinase; Reviewed; Region: PRK12686
208435006621	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
208435006622	putative substrate binding site [chemical binding]; other site
208435006623	nucleotide binding site [chemical binding]; other site
208435006624	nucleotide binding site [chemical binding]; other site
208435006625	homodimer interface [polypeptide binding]; other site
208435006626	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
208435006627	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
208435006628	active site
208435006629	HIGH motif; other site
208435006630	dimer interface [polypeptide binding]; other site
208435006631	KMSKS motif; other site
208435006632	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
208435006633	Uncharacterized conserved protein [Function unknown]; Region: COG1284
208435006634	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
208435006635	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
208435006636	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
208435006637	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
208435006638	Walker A/P-loop; other site
208435006639	ATP binding site [chemical binding]; other site
208435006640	Q-loop/lid; other site
208435006641	ABC transporter signature motif; other site
208435006642	Walker B; other site
208435006643	D-loop; other site
208435006644	H-loop/switch region; other site
208435006645	ABC transporter; Region: ABC_tran_2; pfam12848
208435006646	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
208435006647	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
208435006648	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
208435006649	periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038
208435006650	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
208435006651	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
208435006652	protein binding site [polypeptide binding]; other site
208435006653	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
208435006654	ParB-like nuclease domain; Region: ParBc; pfam02195
208435006655	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775