-- dump date 20140620_072333 -- class Genbank::CDS -- table cds_note -- id note YP_004410625.1 COGs: COG0593 ATPase involved in DNA replication initiation; HAMAP: Chromosomal replication control, initiator DnaA; InterPro IPR001957:IPR013317:IPR013159:IPR003593; KEGG: ssm:Spirs_0001 chromosomal replication initiator protein DnaA; PFAM: Chromosomal replication control, initiator (DnaA)/regulator (Hda); Chromosomal replication initiator, DnaA C-terminal; SMART: Chromosomal replication initiator, DnaA C-terminal; ATPase, AAA+ type, core; SPTR: Chromosomal replication initiator protein DnaA; TIGRFAM: Chromosomal replication control, initiator DnaA; IMG reference gene:2503956265; PFAM: domain; Bacterial dnaA protein; TIGRFAM: chromosomal replication initiator protein DnaA YP_004410626.1 COGs: COG0592 DNA polymerase sliding clamp subunit (PCNA homolog); InterPro IPR001001:IPR022634:IPR022637:IPR022635; KEGG: ssm:Spirs_0003 DNA polymerase III, beta subunit; PFAM: DNA polymerase III, beta chain, central; DNA polymerase III, beta chain, N-terminal; DNA polymerase III, beta chain, C-terminal; PRIAM: DNA-directed DNA polymerase; SMART: DNA polymerase III, beta chain; SPTR: DNA polymerase III, beta subunit; TIGRFAM: DNA polymerase III, beta chain; IMG reference gene:2503956266; PFAM: DNA polymerase III beta subunit, C-terminal domain; DNA polymerase III beta subunit, N-terminal domain; DNA polymerase III beta subunit, central domain; TIGRFAM: DNA polymerase III, beta subunit YP_004410627.1 COGs: COG1195 Recombinational DNA repair ATPase (RecF pathway); HAMAP: DNA-binding, RecF; InterPro IPR001238:IPR003395; KEGG: ssm:Spirs_0004 DNA replication and repair protein RecF; PFAM: RecF/RecN/SMC; SPTR: DNA replication and repair protein recF; TIGRFAM: DNA-binding, RecF; IMG reference gene:2503956267; PFAM: RecF/RecN/SMC N terminal domain; TIGRFAM: recF protein YP_004410628.1 InterPro IPR007922; KEGG: ssm:Spirs_0005 protein of unknown function DUF721; PFAM: Protein of unknown function DUF721/UPF0232; SPTR: uncharacterized protein; IMG reference gene:2503956268; PFAM: Protein of unknown function (DUF721) YP_004410629.1 HAMAP: Ribosomal protein L34; InterPro IPR000271; KEGG: ssm:Spirs_0006 ribosomal protein L34; PFAM: Ribosomal protein L34; SPTR: 50S ribosomal protein L34; TIGRFAM: Ribosomal protein L34; IMG reference gene:2503956269; PFAM: Ribosomal protein L34; TIGRFAM: ribosomal protein L34, bacterial type YP_004410630.1 HAMAP: Ribonuclease P; InterPro IPR000100; KEGG: ssm:Spirs_0007 ribonuclease P protein component; PFAM: Ribonuclease P; SPTR: Ribonuclease P protein component; TIGRFAM: Ribonuclease P; IMG reference gene:2503956270; PFAM: Ribonuclease P; TIGRFAM: ribonuclease P protein component, eubacterial YP_004410631.1 COGs: COG0706 Preprotein translocase subunit YidC; HAMAP: Membrane insertion protein, OxaA/YidC, bacterial; InterPro IPR019998:IPR001708; KEGG: ssm:Spirs_0008 membrane protein insertase, YidC/Oxa1 family; PFAM: Membrane insertion protein, OxaA/YidC; SPTR: uncharacterized protein; TIGRFAM: Membrane insertion protein, OxaA/YidC; Membrane insertion protein, OxaA/YidC, bacterial; IMG reference gene:2503956271; PFAM: 60Kd inner membrane protein; TIGRFAM: membrane protein insertase, YidC/Oxa1 family, C-terminal domain; membrane protein insertase, YidC/Oxa1 family, N-terminal domain YP_004410632.1 COGs: COG1847 RNA-binding protein; InterPro IPR001374; KEGG: ssm:Spirs_0009 single-stranded nucleic acid binding R3H domain protein; PFAM: Single-stranded nucleic acid binding R3H; SMART: Single-stranded nucleic acid binding R3H; SPTR: Protein jag; IMG reference gene:2503956272; PFAM: R3H domain YP_004410633.1 COGs: COG0169 Shikimate 5-dehydrogenase; KEGG: art:Arth_1802 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956273 YP_004410634.1 COGs: COG2140 Thermophilic glucose-6-phosphate isomerase and related metalloenzyme; InterPro IPR010551; KEGG: art:Arth_1801 glucose-6-phosphate isomerase; PFAM: Glucose-6-phosphate isomerase, prokaryote; PRIAM: Glucose-6-phosphate isomerase; SPTR: Glucose-6-phosphate isomerase; IMG reference gene:2503956274; PFAM: Glucose-6-phosphate isomerase (GPI) YP_004410635.1 COGs: COG2220 Zn-dependent hydrolase of the beta-lactamase fold; KEGG: art:Arth_1808 Zn-dependent hydrolases of the beta-lactamase fold-like protein; SPTR: Zn-dependent hydrolases of the beta-lactamase fold-like protein; IMG reference gene:2503956275 YP_004410636.1 COGs: COG2188 Transcriptional regulators; InterPro IPR000524:IPR011663; KEGG: tna:CTN_0371 transcriptional regulator, GntR family; PFAM: UbiC transcription regulator-associated; HTH transcriptional regulator, GntR; SMART: UbiC transcription regulator-associated; HTH transcriptional regulator, GntR; SPTR: Transcriptional regulator, GntR family; IMG reference gene:2503956276; PFAM: Bacterial regulatory proteins, gntR family; UTRA domain YP_004410637.1 COGs: COG3829 Transcriptional regulator containing PAS AAA-type ATPase and DNA-binding domains; InterPro IPR002078:IPR002197:IPR003593; KEGG: dma:DMR_16710 fis family transcriptional regulator; PFAM: RNA polymerase sigma factor 54, interaction; Helix-turn-helix, Fis-type; SMART: ATPase, AAA+ type, core; SPTR: Sigma-54 interaction domain family protein; IMG reference gene:2503956277; PFAM: Bacterial regulatory protein, Fis family; Sigma-54 interaction domain YP_004410638.1 COGs: COG1879 ABC-type sugar transport system periplasmic component; KEGG: tle:Tlet_0182 periplasmic binding protein/LacI transcriptional regulator; SPTR: Periplasmic binding protein/LacI transcriptional regulator; IMG reference gene:2503956278; PFAM: family YP_004410639.1 COGs: COG1129 ABC-type sugar transport system ATPase component; InterPro IPR003439:IPR003593; KEGG: csh:Closa_1201 ABC transporter related protein; PFAM: ABC transporter-like; PRIAM: Monosaccharide-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter related protein; IMG reference gene:2503956279; PFAM: ABC transporter YP_004410640.1 COGs: COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems permease components; InterPro IPR001851; KEGG: tle:Tlet_0185 monosaccharide-transporting ATPase; PFAM: ABC transporter permease; SPTR: Monosaccharide-transporting ATPase; IMG reference gene:2503956280; PFAM: Branched-chain amino acid transport system / permease component YP_004410641.1 COGs: COG1070 Sugar (pentulose and hexulose) kinase; InterPro IPR018484:IPR018485; KEGG: bth:BT_4423 xylulose kinase; PFAM: Carbohydrate kinase, FGGY, N-terminal; Carbohydrate kinase, FGGY, C-terminal; PRIAM: Xylulokinase; SPTR: Xylulokinase; IMG reference gene:2503956281; PFAM: FGGY family of carbohydrate kinases, N-terminal domain; FGGY family of carbohydrate kinases, C-terminal domain YP_004410642.1 COGs: COG1070 Sugar (pentulose and hexulose) kinase; InterPro IPR018484:IPR018485; KEGG: bth:BT_4423 xylulose kinase; PFAM: Carbohydrate kinase, FGGY, N-terminal; Carbohydrate kinase, FGGY, C-terminal; SPTR: Xylulokinase; IMG reference gene:2503956282; PFAM: FGGY family of carbohydrate kinases, N-terminal domain; FGGY family of carbohydrate kinases, C-terminal domain YP_004410643.1 KEGG: car:cauri_0369 DNA-directed RNA polymerase subunit beta'; SPTR: DNA-directed RNA polymerase subunit beta'; IMG reference gene:2503956283 YP_004410644.1 COGs: COG0667 oxidoreductase (related to aryl-alcohol dehydrogenase); InterPro IPR023210; KEGG: hoh:Hoch_6537 aldo/keto reductase; PFAM: NADP-dependent oxidoreductase domain; PRIAM: Aryl-alcohol dehydrogenase (NADP(+)); SPTR: Aldo/keto reductase; IMG reference gene:2503956284; PFAM: Aldo/keto reductase YP_004410645.1 COGs: COG0524 Sugar kinase ribokinase; InterPro IPR011877:IPR011611; KEGG: csh:Closa_1899 ribokinase; PFAM: Carbohydrate/purine kinase; PRIAM: Ribokinase; SPTR: uncharacterized protein; TIGRFAM: Ribokinase, bacterial; IMG reference gene:2503956285; PFAM: pfkB family carbohydrate kinase; TIGRFAM: ribokinase YP_004410646.1 COGs: COG2188 Transcriptional regulators; InterPro IPR000524:IPR011663; KEGG: lac:LBA0393 transcriptional regulator; PFAM: UbiC transcription regulator-associated; HTH transcriptional regulator, GntR; SMART: UbiC transcription regulator-associated; HTH transcriptional regulator, GntR; SPTR: uncharacterized protein; IMG reference gene:2503956286; PFAM: Bacterial regulatory proteins, gntR family; UTRA domain YP_004410647.1 COGs: COG1052 Lactate dehydrogenase and related dehydrogenase; InterPro IPR006139:IPR006140; KEGG: tpd:Teth39_2074 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; PRIAM: Phosphoglycerate dehydrogenase; SPTR: uncharacterized protein; IMG reference gene:2503956287; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain YP_004410648.1 COGs: COG0192 S-adenosylmethionine synthetase; HAMAP: S-adenosylmethionine synthetase; InterPro IPR002133:IPR022628:IPR022629:IPR022630; KEGG: sta:STHERM_c00130 S-adenosylmethionine synthetase; PFAM: S-adenosylmethionine synthetase, C-terminal; S-adenosylmethionine synthetase, central domain; S-adenosylmethionine synthetase, N-terminal; PRIAM: Methionine adenosyltransferase; SPTR: S-adenosylmethionine synthetase; TIGRFAM: S-adenosylmethionine synthetase; IMG reference gene:2503956288; PFAM: S-adenosylmethionine synthetase, C-terminal domain; S-adenosylmethionine synthetase, central domain; S-adenosylmethionine synthetase, N-terminal domain; TIGRFAM: S-adenosylmethionine synthetase YP_004410649.1 COGs: COG0182 translation initiation factor 2B subunit eIF-2B alpha/beta/delta family; HAMAP: translation initiation factor, aIF-2BI/5-methylthioribose-1-phosphate isomerase; InterPro IPR005251:IPR011559:IPR000649; KEGG: cpy:Cphy_2033 aIF-2BI family translation initiation factor; PFAM: Initiation factor 2B-related; PRIAM: S-methyl-5-thioribose-1-phosphate isomerase; SPTR: Methylthioribose-1-phosphate isomerase; TIGRFAM: translation initiation factor, aIF-2BI/5-methylthioribose-1-phosphate isomerase; Initiation factor 2B alpha/beta/delta; IMG reference gene:2503956289; PFAM: Initiation factor 2 subunit family; TIGRFAM: eIF-2B alpha/beta/delta-related uncharacterized proteins; S-methyl-5-thioribose-1-phosphate isomerase YP_004410650.1 COGs: COG0524 Sugar kinase ribokinase; InterPro IPR011611; KEGG: ssm:Spirs_4279 PfkB domain protein; PFAM: Carbohydrate/purine kinase; SPTR: Glr0791 protein; IMG reference gene:2503956290; PFAM: pfkB family carbohydrate kinase YP_004410651.1 COGs: COG0766 UDP-N-acetylglucosamine enolpyruvyl transferase; HAMAP: UDP-N-acetylglucosamine 1-carboxyvinyltransferase; InterPro IPR005750:IPR001986; KEGG: sta:STHERM_c00510 hypothetical protein; PFAM: Enolpyruvate transferase domain; PRIAM: UDP-N-acetylglucosamine 1-carboxyvinyltransferase; SPTR: uncharacterized protein; TIGRFAM: UDP-N-acetylglucosamine 1-carboxyvinyltransferase; IMG reference gene:2503956291; PFAM: EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); TIGRFAM: UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_004410652.1 IMG reference gene:2503956292 YP_004410653.1 COGs: COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains; InterPro IPR002078:IPR003593; KEGG: dds:Ddes_2345 sigma54 specific transcriptional regulator, fis family; PFAM: RNA polymerase sigma factor 54, interaction; SMART: ATPase, AAA+ type, core; SPTR: Sigma54 specific transcriptional regulator, Fis family; IMG reference gene:2503956293; PFAM: Sigma-54 interaction domain YP_004410654.1 KEGG: tva:TVAG_082020 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956294; PFAM: Peptidase M28 YP_004410655.1 COGs: COG1739 conserved hypothetical protein; InterPro IPR001498; KEGG: tde:TDE1321 hypothetical protein; PFAM: Uncharacterised protein family UPF0029, Impact, N-terminal; SPTR: uncharacterized protein; IMG reference gene:2503956295; PFAM: Uncharacterized protein family UPF0029; Domain of unknown function (DUF1949); TIGRFAM: uncharacterized protein, YigZ family YP_004410656.1 InterPro IPR000086; KEGG: ssm:Spirs_0099 NUDIX hydrolase; PFAM: NUDIX hydrolase domain; SPTR: MutT family protein, 78-dihydro-8-oxoguanine triphosphatase (8-oxo-dGTPase); IMG reference gene:2503956296; PFAM: NUDIX domain YP_004410657.1 KEGG: mpd:MCP_1774 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956297 YP_004410658.1 COGs: COG0206 Cell division GTPase; InterPro IPR003008; KEGG: cth:Cthe_0445 cell division protein FtsZ; PFAM: Tubulin/FtsZ, GTPase domain; SMART: Tubulin/FtsZ, GTPase domain; SPTR: Cell division protein ftsZ; IMG reference gene:2503956298; PFAM: Tubulin/FtsZ family, GTPase domain; TIGRFAM: cell division protein FtsZ YP_004410659.1 KEGG: pop:POPTR_247422 hypothetical protein; SPTR: Chaperone protein dnaJ; IMG reference gene:2503956299 YP_004410660.1 COGs: COG0274 Deoxyribose-phosphate aldolase; HAMAP: Deoxyribose-phosphate aldolase, type 1; InterPro IPR011343:IPR022979:IPR002915; KEGG: gwc:GWCH70_2432 deoxyribose-phosphate aldolase; PFAM: Deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; PRIAM: Deoxyribose-phosphate aldolase; SPTR: Deoxyribose-phosphate aldolase; TIGRFAM: Deoxyribose-phosphate aldolase; IMG reference gene:2503956300; PFAM: DeoC/LacD family aldolase; TIGRFAM: deoxyribose-phosphate aldolase YP_004410661.1 COGs: COG1435 Thymidine kinase; InterPro IPR001267; KEGG: ssm:Spirs_0100 thymidine kinase; PFAM: Thymidine kinase; SPTR: Thymidine kinase; IMG reference gene:2503956301; PFAM: Thymidine kinase YP_004410662.1 COGs: COG1082 Sugar phosphate isomerase/epimerase; InterPro IPR012307; KEGG: sta:STHERM_c04340 xylose isomerase domain-containing protein TIM barrel; PFAM: Xylose isomerase, TIM barrel domain; SPTR: Xylose isomerase domain protein TIM barrel; IMG reference gene:2503956302; PFAM: Xylose isomerase-like TIM barrel YP_004410663.1 COGs: COG5434 Endopygalactorunase; InterPro IPR000743:IPR006626; KEGG: sta:STHERM_c04310 hypothetical protein; PFAM: Glycoside hydrolase, family 28; PRIAM: Polygalacturonase; SPTR: uncharacterized protein; IMG reference gene:2503956303; PFAM: Glycosyl hydrolases family 28 YP_004410664.1 IMG reference gene:2503956304 YP_004410665.1 COGs: COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase; InterPro IPR000887; KEGG: bpb:bpr_I0931 2-keto-3-deoxygluconate 6-phosphate aldolase/2-keto-4-hydroxyglutarate aldolase; PFAM: KDPG/KHG aldolase; PRIAM: 2-dehydro-3-deoxy-phosphogluconate aldolase; SPTR: Entner-Doudoroff aldolase; TIGRFAM: KDPG/KHG aldolase; IMG reference gene:2503956305; PFAM: KDPG and KHG aldolase; TIGRFAM: Entner-Doudoroff aldolase YP_004410666.1 COGs: COG0524 Sugar kinase ribokinase; InterPro IPR011611; KEGG: ssm:Spirs_3585 PfkB domain protein; PFAM: Carbohydrate/purine kinase; SPTR: KHG/KDPG family aldolase/carbohydrate kinase, PfkB family; IMG reference gene:2503956306; PFAM: pfkB family carbohydrate kinase YP_004410667.1 KEGG: bth:BT_3630 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956307 YP_004410668.1 COGs: COG0350 Methylated DNA-protein cysteine methyltransferase; InterPro IPR014048:IPR008332; KEGG: aoe:Clos_0936 methylated-DNA--protein-cysteine methyltransferase; PFAM: Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding; Methylguanine DNA methyltransferase, ribonuclease-like; SPTR: Methylated-DNA-protein-cysteine methyltransferase; TIGRFAM: Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding; IMG reference gene:2503956308; PFAM: 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; 6-O-methylguanine DNA methyltransferase, DNA binding domain; TIGRFAM: O-6-methylguanine DNA methyltransferase YP_004410669.1 COGs: COG1414 Transcriptional regulator; InterPro IPR005471:IPR014757; KEGG: etr:ETAE_1567 pectin degradation repressor; PFAM: Transcription regulator IclR, C-terminal; Transcription regulator IclR, N-terminal; SMART: Transcription regulator IclR, N-terminal; SPTR: Pectin degradation repressor; IMG reference gene:2503956309; PFAM: IclR helix-turn-helix domain; Bacterial transcriptional regulator YP_004410670.1 COGs: COG1904 Glucuronate isomerase; HAMAP: Uronate isomerase; InterPro IPR003766; KEGG: ttm:Tthe_2404 glucuronate isomerase; PFAM: Uronate isomerase; PRIAM: Glucuronate isomerase; SPTR: Uronate isomerase; IMG reference gene:2503956310; PFAM: Glucuronate isomerase YP_004410671.1 COGs: COG2721 Altronate dehydratase; InterPro IPR013974:IPR007392; KEGG: str:Sterm_0691 altronate dehydratase; PFAM: D-galactarate dehydratase/Altronate hydrolase, C-terminal; SAF domain; PRIAM: Altronate dehydratase; SMART: SAF domain; SPTR: Altronate dehydratase; IMG reference gene:2503956311; PFAM: SAF domain; D-galactarate dehydratase / Altronate hydrolase, C terminus YP_004410672.1 COGs: COG0246 Mannitol-1-phosphate/altronate dehydrogenase; InterPro IPR013131:IPR013118; KEGG: amt:Amet_0555 altronate oxidoreductase; PFAM: Mannitol dehydrogenase, C-terminal; Mannitol dehydrogenase, N-terminal; PRIAM: Tagaturonate reductase; SPTR: Mannitol dehydrogenase, C-terminal domain; IMG reference gene:2503956312; PFAM: Mannitol dehydrogenase C-terminal domain; Mannitol dehydrogenase Rossmann domain YP_004410673.1 COGs: COG0385 Na+-dependent transporter; InterPro IPR002657; KEGG: bao:BAMF_0163 sodium dependent transporter; PFAM: Bile acid:sodium symporter; SPTR: Bile acid:sodium symporter; IMG reference gene:2503956313; PFAM: Sodium Bile acid symporter family YP_004410674.1 KEGG: bmq:BMQ_1790 secreted protein; SPTR: secreted protein; IMG reference gene:2503956314 YP_004410675.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR011110:IPR000408; KEGG: aeh:Mlg_2688 regulator of chromosome condensation, RCC1; PFAM: Regulator of chromosome condensation, RCC1; Two component regulator propeller; SPTR: Alpha-tubulin suppressor and related RCC1 domain-containing protein-like protein; IMG reference gene:2503956315; PFAM: Regulator of chromosome condensation (RCC1) repeat YP_004410676.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR013378:IPR011110:IPR000408; KEGG: aeh:Mlg_2687 regulator of chromosome condensation, RCC1; PFAM: Listeria/Bacterioides repeat; Two component regulator propeller; Regulator of chromosome condensation, RCC1; SPTR: uncharacterized protein; IMG reference gene:2503956316; PFAM: Listeria-Bacteroides repeat domain (List_Bact_rpt); Regulator of chromosome condensation (RCC1) repeat YP_004410677.1 IMG reference gene:2503956317 YP_004410678.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR013378:IPR011110:IPR000408; KEGG: dal:Dalk_3426 regulator of chromosome condensation RCC1; PFAM: Listeria/Bacterioides repeat; Two component regulator propeller; Regulator of chromosome condensation, RCC1; SPTR: uncharacterized protein; IMG reference gene:2503956318; PFAM: Listeria-Bacteroides repeat domain (List_Bact_rpt); Regulator of chromosome condensation (RCC1) repeat YP_004410679.1 COGs: COG1609 Transcriptional regulators; InterPro IPR001761:IPR000005:IPR018060; KEGG: cag:Cagg_2054 two component transcriptional regulator, AraC family; PFAM: HTH transcriptional regulator, AraC; Periplasmic binding protein/LacI transcriptional regulator; SMART: Helix-turn-helix, AraC type, DNA binding domain; SPTR: Two component transcriptional regulator, AraC family; IMG reference gene:2503956319; PFAM: Bacterial regulatory helix-turn-helix proteins, AraC family; family YP_004410680.1 COGs: COG4209 ABC-type polysaccharide transport system permease component; InterPro IPR000515; KEGG: mrb:Mrub_0281 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Binding-protein-dependent transport systems inner membrane component; IMG reference gene:2503956320; PFAM: Binding-protein-dependent transport system inner membrane component YP_004410681.1 COGs: COG0395 ABC-type sugar transport system permease component; InterPro IPR000515; KEGG: mrb:Mrub_0280 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Binding-protein-dependent transport systems inner membrane component; IMG reference gene:2503956321; PFAM: Binding-protein-dependent transport system inner membrane component YP_004410682.1 COGs: COG1653 ABC-type sugar transport system periplasmic component; InterPro IPR006059; KEGG: mrb:Mrub_0279 extracellular solute-binding protein family 1; PFAM: Bacterial extracellular solute-binding, family 1; SPTR: Extracellular solute-binding protein family 1; IMG reference gene:2503956322; PFAM: Bacterial extracellular solute-binding protein YP_004410683.1 COGs: COG4225 unsaturated glucuronyl hydrolase involved in regulation of surface properties and related protein; InterPro IPR010905; KEGG: rmr:Rmar_2470 glycosyl hydrolase 88; PFAM: Glycosyl hydrolase, family 88; SPTR: Glycosyl hydrolase 88; IMG reference gene:2503956323; PFAM: Glycosyl Hydrolase 88 YP_004410684.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR011110:IPR000408; KEGG: aeh:Mlg_2687 regulator of chromosome condensation, RCC1; PFAM: Regulator of chromosome condensation, RCC1; Two component regulator propeller; SPTR: uncharacterized protein; IMG reference gene:2503956324; PFAM: Regulator of chromosome condensation (RCC1) repeat YP_004410685.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR013378:IPR000408; KEGG: aeh:Mlg_2687 regulator of chromosome condensation, RCC1; PFAM: Listeria/Bacterioides repeat; Regulator of chromosome condensation, RCC1; SPTR: uncharacterized protein; IMG reference gene:2503956325; PFAM: Listeria-Bacteroides repeat domain (List_Bact_rpt); Regulator of chromosome condensation (RCC1) repeat YP_004410686.1 COGs: COG1744 Uncharacterized ABC-type transport system periplasmic component/surface lipoprotein; InterPro IPR003760; KEGG: tde:TDE1950 membrane lipoprotein TmpC, PFAM: Basic membrane lipoprotein; SPTR: Membrane lipoprotein tmpc; IMG reference gene:2503956326; PFAM: Basic membrane protein YP_004410687.1 COGs: COG3845 ABC-type uncharacterized transport systems ATPase components; InterPro IPR003439:IPR003593; KEGG: tde:TDE1949 ABC transporter, ATP-binding protein; PFAM: ABC transporter-like; PRIAM: Monosaccharide-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter, ATP-binding protein; IMG reference gene:2503956327; PFAM: ABC transporter YP_004410688.1 COGs: COG4603 ABC-type uncharacterized transport system permease component; InterPro IPR001851; KEGG: tde:TDE1948 ABC transporter, permease; PFAM: ABC transporter permease; SPTR: ABC transporter, permease; IMG reference gene:2503956328; PFAM: Branched-chain amino acid transport system / permease component YP_004410689.1 COGs: COG1079 ABC-type transport system permease component; InterPro IPR001851; KEGG: tde:TDE1947 ABC transporter, permease; PFAM: ABC transporter permease; SPTR: ABC transporter, permease; IMG reference gene:2503956329; PFAM: Branched-chain amino acid transport system / permease component YP_004410690.1 COGs: COG0005 Purine nucleoside phosphorylase; InterPro IPR011268:IPR011270:IPR000845; KEGG: ssm:Spirs_4139 purine nucleoside phosphorylase I, inosine and guanosine-specific; PFAM: Nucleoside phosphorylase domain; PRIAM: Purine-nucleoside phosphorylase; SPTR: Purine nucleoside phosphorylase I, inosine and guanosine-specific; TIGRFAM: Inosine guanosine/xanthosine phosphorylase; Purine nucleoside phosphorylase I, inosine/guanosine-specific; IMG reference gene:2503956330; PFAM: Phosphorylase superfamily; TIGRFAM: purine nucleoside phosphorylase I, inosine and guanosine-specific; inosine guanosine and xanthosine phosphorylase YP_004410691.1 COGs: COG3542 conserved hypothetical protein; InterPro IPR009327; KEGG: sco:SCO4051 hypothetical protein; PFAM: Protein of unknown function DUF985; SPTR: uncharacterized protein; IMG reference gene:2503956331; PFAM: Cupin superfamily (DUF985) YP_004410692.1 COGs: COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase); InterPro IPR002198:IPR020842; KEGG: ssm:Spirs_3584 short-chain dehydrogenase/reductase SDR; PFAM: Short-chain dehydrogenase/reductase SDR; PRIAM: 3-oxoacyl-[acyl-carrier-protein] reductase; SMART: Polyketide synthase/Fatty acid synthase, KR; SPTR: Short-chain dehydrogenase/reductase SDR; IMG reference gene:2503956332; PFAM: short chain dehydrogenase YP_004410693.1 COGs: COG2129 phosphoesterase related to the Icc protein; InterPro IPR004843; KEGG: sta:STHERM_c06590 Ser/Thr protein phosphatase; PFAM: Metallo-dependent phosphatase; SPTR: Metallophosphoesterase; IMG reference gene:2503956333; PFAM: Calcineurin-like phosphoesterase YP_004410694.1 KEGG: ssm:Spirs_2366 hypothetical protein; SPTR: Transcriptional regulator; IMG reference gene:2503956334 YP_004410695.1 KEGG: cdf:CD1458 flavoprotein; SPTR: Probable flavoprotein; IMG reference gene:2503956335; PFAM: NADPH-dependent FMN reductase YP_004410696.1 COGs: COG1119 ABC-type molybdenum transport system ATPase component/photorepair protein PhrA; InterPro IPR003439:IPR003593; KEGG: mma:MM_0570 ABC transporter, ATP-binding protein; PFAM: ABC transporter-like; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter, ATP-binding protein; IMG reference gene:2503956336; PFAM: ABC transporter YP_004410697.1 COGs: COG2186 Transcriptional regulators; InterPro IPR000524; KEGG: ssm:Spirs_1347 GntR domain protein; PFAM: HTH transcriptional regulator, GntR; SMART: HTH transcriptional regulator, GntR; SPTR: Transcriptional regulator; IMG reference gene:2503956337; PFAM: Bacterial regulatory proteins, gntR family; FCD domain YP_004410698.1 IMG reference gene:2503956338 YP_004410699.1 KEGG: tgu:100225112 similar to ARID4B variant protein; SPTR: Type I secretion outer membrane protein, TolC family; IMG reference gene:2503956339 YP_004410700.1 COGs: COG1760 L-serine deaminase; InterPro IPR005131:IPR005130; KEGG: bfs:BF1216 L-serine dehydratase; PFAM: Serine dehydratase-like, alpha subunit; Serine dehydratase beta chain; PRIAM: L-serine ammonia-lyase; SPTR: L-serine dehydratase; IMG reference gene:2503956340; PFAM: Serine dehydratase alpha chain; Serine dehydratase beta chain; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, single chain form YP_004410701.1 COGs: COG1609 Transcriptional regulators; InterPro IPR000843:IPR001761; KEGG: ssm:Spirs_0788 transcriptional regulator, LacI family; PFAM: HTH transcriptional regulator, LacI; Periplasmic binding protein/LacI transcriptional regulator; SMART: HTH transcriptional regulator, LacI; SPTR: Transcriptional regulator, LacI family; IMG reference gene:2503956341; PFAM: Bacterial regulatory proteins, lacI family; family YP_004410702.1 COGs: COG1879 ABC-type sugar transport system periplasmic component; InterPro IPR001761; KEGG: ssm:Spirs_1666 periplasmic binding protein/LacI transcriptional regulator; PFAM: Periplasmic binding protein/LacI transcriptional regulator; SPTR: D-ribose-binding periplasmic protein; IMG reference gene:2503956342; PFAM: family YP_004410703.1 COGs: COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems permease components; InterPro IPR001851; KEGG: ssm:Spirs_1665 inner-membrane translocator; PFAM: ABC transporter permease; SPTR: Ribose ABC transporter (Permease); IMG reference gene:2503956343; PFAM: Branched-chain amino acid transport system / permease component YP_004410704.1 COGs: COG0673 dehydrogenase and related protein; InterPro IPR000683:IPR004104; KEGG: ssm:Spirs_1664 oxidoreductase domain protein; PFAM: Oxidoreductase, N-terminal; Oxidoreductase, C-terminal; PRIAM: Inositol 2-dehydrogenase; SPTR: Myo-inositol 2-dehydrogenase; IMG reference gene:2503956344; PFAM: Oxidoreductase, NAD-binding Rossmann fold; Oxidoreductase, C-terminal alpha/beta domain YP_004410705.1 COGs: COG1129 ABC-type sugar transport system ATPase component; InterPro IPR003439:IPR003593; KEGG: ssm:Spirs_1663 ABC transporter related protein; PFAM: ABC transporter-like; PRIAM: Monosaccharide-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: Ribose import ATP-binding protein RbsA; IMG reference gene:2503956345; PFAM: ABC transporter YP_004410706.1 COGs: COG0673 dehydrogenase and related protein; InterPro IPR000683:IPR004104; KEGG: kol:Kole_0987 oxidoreductase domain protein; PFAM: Oxidoreductase, N-terminal; Oxidoreductase, C-terminal; PRIAM: Inositol 2-dehydrogenase; SPTR: Oxidoreductase domain protein; IMG reference gene:2503956346; PFAM: Oxidoreductase, NAD-binding Rossmann fold; Oxidoreductase, C-terminal alpha/beta domain YP_004410707.1 COGs: COG3718 Uncharacterized protein involved in inositol metabolism; KEGG: kol:Kole_0990 myo-inositol catabolism IolB domain protein; SPTR: Myo-inositol catabolism IolB domain protein; IMG reference gene:2503956347; PFAM: KduI/IolB family YP_004410708.1 COGs: COG3962 Acetolactate synthase; InterPro IPR012001:IPR012000:IPR011766; KEGG: ssm:Spirs_2987 thiamine pyrophosphate protein domain protein TPP-binding protein; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding; PRIAM: Acetolactate synthase; SPTR: Thiamine pyrophosphate protein central region; IMG reference gene:2503956348; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain YP_004410709.1 COGs: COG1082 Sugar phosphate isomerase/epimerase; HAMAP: Inosose dehydratase; InterPro IPR012307; KEGG: str:Sterm_4013 myo-inosose-2 dehydratase; PFAM: Xylose isomerase, TIM barrel domain; PRIAM: Myo-inosose-2 dehydratase; SPTR: Myo-inosose-2 dehydratase; IMG reference gene:2503956349; PFAM: Xylose isomerase-like TIM barrel YP_004410710.1 COGs: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; InterPro IPR006436:IPR005106:IPR020829:IPR020828; KEGG: ssm:Spirs_0990 glyceraldehyde-3-phosphate dehydrogenase, type II; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; Aspartate/homoserine dehydrogenase, NAD-binding; PRIAM: Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)) (phosphorylating); SMART: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; SPTR: Glyceraldehyde-3-phosphate dehydrogenase, type II; TIGRFAM: Glyceraldehyde-3-phosphate dehydrogenase, type II; IMG reference gene:2503956350; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type II YP_004410711.1 COGs: COG0126 3-phosphoglycerate kinase; InterPro IPR001576; KEGG: ssm:Spirs_0989 phosphoglycerate kinase; PFAM: Phosphoglycerate kinase; PRIAM: Phosphoglycerate kinase; SPTR: Phosphoglycerate kinase; IMG reference gene:2503956351; PFAM: Phosphoglycerate kinase YP_004410712.1 COGs: COG3875 conserved hypothetical protein; InterPro IPR018657; KEGG: ssm:Spirs_0988 protein of unknown function DUF2088; PFAM: Protein of unknown function DUF2088; SPTR: General glycosylation pathway protein; IMG reference gene:2503956352; PFAM: NNMT/PNMT/TEMT family; Uncharacterized conserved protein (DUF2088) YP_004410713.1 COGs: COG0495 Leucyl-tRNA synthetase; InterPro IPR002302:IPR015413:IPR013155; KEGG: ssm:Spirs_0283 leucyl-tRNA synthetase; PFAM: Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding; Aminoacyl-tRNA synthetase, class I (M); PRIAM: Leucine--tRNA ligase; SPTR: Leucyl-tRNA synthetase; TIGRFAM: Leucyl-tRNA synthetase, class Ia, bacterial/mitochondrial; IMG reference gene:2503956353; PFAM: tRNA synthetases class I (I, L, M and V); Anticodon-binding domain; TIGRFAM: leucyl-tRNA synthetase, eubacterial and mitochondrial family YP_004410714.1 COGs: COG3177 conserved hypothetical protein; InterPro IPR003812; KEGG: afn:Acfer_1163 filamentation induced by cAMP protein Fic; PFAM: Filamentation induced by cAMP/death on curing-related; SPTR: uncharacterized protein; IMG reference gene:2503956354; PFAM: Fic/DOC family YP_004410715.1 COGs: COG2116 Formate/nitrite family of transporter; InterPro IPR000292; KEGG: str:Sterm_3165 formate/nitrite transporter; PFAM: Formate/nitrite transporter; SPTR: Formate/nitrite transporter; IMG reference gene:2503956355; PFAM: Formate/nitrite transporter; TIGRFAM: formate/nitrite transporter YP_004410716.1 COGs: COG0293 23S rRNA methylase; HAMAP: Ribosomal RNA large subunit methyltransferase E; InterPro IPR015507:IPR002877; KEGG: ssm:Spirs_0297 ribosomal RNA methyltransferase RrmJ/FtsJ; PFAM: Ribosomal RNA methyltransferase RrmJ/FtsJ; SPTR: Ribosomal RNA large subunit methyltransferase E; IMG reference gene:2503956356; PFAM: FtsJ-like methyltransferase; TIGRFAM: cell division protein FtsJ YP_004410717.1 COGs: COG0523 GTPase (G3E family); InterPro IPR003495:IPR011629; KEGG: bur:Bcep18194_A3246 cobalamin synthesis protein/P47K; PFAM: Cobalamin (vitamin B12) biosynthesis CobW-like; Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal; SMART: Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal; SPTR: Cobalamin synthesis protein/P47K; IMG reference gene:2503956357; PFAM: CobW/HypB/UreG, nucleotide-binding domain; Cobalamin synthesis protein cobW C-terminal domain YP_004410718.1 COGs: COG1940 Transcriptional regulator/sugar kinase; InterPro IPR000600; KEGG: eat:EAT1b_0550 glucokinase, ROK family; PFAM: ROK; PRIAM: Glucokinase; SPTR: Glucokinase, ROK family; IMG reference gene:2503956358; PFAM: ROK family; TIGRFAM: ROK family protein ( glucokinase) YP_004410719.1 COGs: COG1882 Pyruvate-formate lyase; InterPro IPR010098:IPR004184:IPR001150; KEGG: cbe:Cbei_0705 pyruvate formate-lyase; PFAM: Pyruvate formate-lyase, PFL; Formate C-acetyltransferase glycine radical; PRIAM: Formate C-acetyltransferase; SPTR: Pyruvate formate-lyase; TIGRFAM: Pyruvate formate-lyase; IMG reference gene:2503956359; PFAM: Glycine radical; Pyruvate formate lyase; TIGRFAM: pyruvate formate-lyase YP_004410720.1 COGs: COG1349 Transcriptional regulators of sugar metabolism; InterPro IPR001034:IPR014036; KEGG: cbl:CLK_0642 HTH-type transcriptional regulator YciT; PFAM: HTH transcriptional regulator, DeoR; HTH transcriptional regulator, DeoR N-terminal; SMART: HTH transcriptional regulator, DeoR N-terminal; SPTR: Transcriptional regulator, DeoR family; IMG reference gene:2503956360; PFAM: Bacterial regulatory proteins, deoR family; DeoR-like helix-turn-helix domain YP_004410721.1 COGs: COG1879 ABC-type sugar transport system periplasmic component; KEGG: pin:Ping_2790 bifunctional carbohydrate binding and transport protein; SPTR: Bifunctional carbohydrate binding and transport protein; IMG reference gene:2503956361 YP_004410722.1 COGs: COG1129 ABC-type sugar transport system ATPase component; InterPro IPR003439:IPR003593; KEGG: dtu:Dtur_1644 ABC transporter related; PFAM: ABC transporter-like; PRIAM: Monosaccharide-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter related; IMG reference gene:2503956362; PFAM: ABC transporter YP_004410723.1 COGs: COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems permease components; InterPro IPR001851; KEGG: cbk:CLL_A1530 ribose transport system permease RbsC; PFAM: ABC transporter permease; SPTR: Ribose transport system permease RbsC; IMG reference gene:2503956363; PFAM: Branched-chain amino acid transport system / permease component YP_004410724.1 COGs: COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems permease components; InterPro IPR001851; KEGG: pmu:PM0154 ribose ABC transporter permease; PFAM: ABC transporter permease; SPTR: RbsC; IMG reference gene:2503956364; PFAM: Branched-chain amino acid transport system / permease component YP_004410725.1 COGs: COG1609 Transcriptional regulators; InterPro IPR000843:IPR001761; KEGG: tit:Thit_2113 transcriptional regulator, LacI family; PFAM: HTH transcriptional regulator, LacI; Periplasmic binding protein/LacI transcriptional regulator; SMART: HTH transcriptional regulator, LacI; SPTR: Transcriptional regulator, LacI family; IMG reference gene:2503956365; PFAM: Bacterial regulatory proteins, lacI family; family YP_004410726.1 COGs: COG0673 dehydrogenase and related protein; InterPro IPR000683:IPR004104; KEGG: pjd:Pjdr2_4722 oxidoreductase domain protein; PFAM: Oxidoreductase, N-terminal; Oxidoreductase, C-terminal; SPTR: Oxidoreductase domain protein; manually curated; IMG reference gene:2503956366; PFAM: Oxidoreductase, NAD-binding Rossmann fold; Oxidoreductase, C-terminal alpha/beta domain YP_004410727.1 KEGG: cel:T01G9.5 defective MEIosis family member (mei-1); SPTR: Meiotic spindle formation protein mei-1; IMG reference gene:2503956367 YP_004410728.1 COGs: COG1180 Pyruvate-formate lyase-activating enzyme; InterPro IPR012839:IPR007197:IPR001450; KEGG: clj:CLJU_c25970 pyruvate formate-lyase activating enzyme; PFAM: Radical SAM; 4Fe-4S binding domain; PRIAM: [Formate-C-acetyltransferase]-activating enzyme; SPTR: uncharacterized protein; TIGRFAM: Glycyl radical enzyme-activating; IMG reference gene:2503956368; PFAM: Radical SAM superfamily; TIGRFAM: glycyl-radical enzyme activating protein family YP_004410729.1 COGs: COG1882 Pyruvate-formate lyase; InterPro IPR010098:IPR004184:IPR001150; KEGG: clj:CLJU_c25980 pyruvate formate-lyase; PFAM: Pyruvate formate-lyase, PFL; Formate C-acetyltransferase glycine radical; PRIAM: Formate C-acetyltransferase; SPTR: uncharacterized protein; TIGRFAM: Pyruvate formate-lyase; IMG reference gene:2503956369; PFAM: Glycine radical; Pyruvate formate lyase; TIGRFAM: pyruvate formate-lyase YP_004410730.1 COGs: COG2207 AraC-type DNA-binding domain-containing protein; InterPro IPR000005:IPR018060; KEGG: gym:GYMC10_4683 transcriptional regulator, AraC family; PFAM: HTH transcriptional regulator, AraC; SMART: Helix-turn-helix, AraC type, DNA binding domain; SPTR: uncharacterized protein; IMG reference gene:2503956370; PFAM: Bacterial regulatory helix-turn-helix proteins, AraC family YP_004410731.1 COGs: COG0683 ABC-type branched-chain amino acid transport systems periplasmic component; InterPro IPR001828; KEGG: tde:TDE2361 high-affinity branched chain amino acid ABC transporter, amino acid-binding protein; PFAM: Extracellular ligand-binding receptor; SPTR: Extracellular ligand-binding receptor; IMG reference gene:2503956371; PFAM: Receptor family ligand binding region YP_004410732.1 COGs: COG0559 Branched-chain amino acid ABC-type transport system permease components; InterPro IPR001851; KEGG: tde:TDE2366 high-affinity branched-chain amino acid ABC transporter, permease; PFAM: ABC transporter permease; SPTR: High-affinity branched-chain amino acid ABC transporter, permease; IMG reference gene:2503956372; PFAM: Branched-chain amino acid transport system / permease component YP_004410733.1 COGs: COG4177 ABC-type branched-chain amino acid transport system permease component; InterPro IPR001851; KEGG: tde:TDE2365 high-affinity branched-chain amino acid ABC transporter, permease; PFAM: ABC transporter permease; SPTR: High-affinity branched-chain amino acid ABC transporter, permease; IMG reference gene:2503956373; PFAM: Branched-chain amino acid transport system / permease component YP_004410734.1 COGs: COG0411 ABC-type branched-chain amino acid transport systems ATPase component; InterPro IPR003439:IPR003593; KEGG: bts:Btus_1713 ABC transporter related protein; PFAM: ABC transporter-like; PRIAM: Monosaccharide-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: Amino acid ABC transporter, ATP-binding protein; IMG reference gene:2503956374; PFAM: ABC transporter; Branched-chain amino acid ATP-binding cassette transporter YP_004410735.1 COGs: COG0410 ABC-type branched-chain amino acid transport systems ATPase component; InterPro IPR003439:IPR003593; KEGG: dhd:Dhaf_4922 ABC transporter related; PFAM: ABC transporter-like; SMART: ATPase, AAA+ type, core; SPTR: Branched-chain amino acid ABC superfamily ATP binding cassette transporter, ABC protein; IMG reference gene:2503956375; PFAM: ABC transporter YP_004410736.1 KEGG: aco:Amico_0456 uroporphyrinogen decarboxylase; SPTR: Uroporphyrinogen decarboxylase; IMG reference gene:2503956376; PFAM: Uroporphyrinogen decarboxylase (URO-D) YP_004410737.1 COGs: COG3681 conserved hypothetical protein; HAMAP: Uncharacterised protein family UPF0597; InterPro IPR021144; KEGG: cpy:Cphy_1256 hypothetical protein; SPTR: UPF0597 protein CUW_0913; IMG reference gene:2503956377; PFAM: Serine dehydratase alpha chain YP_004410738.1 COGs: COG0169 Shikimate 5-dehydrogenase; HAMAP: Shikimate, quinate/shikimate dehydrogenase; InterPro IPR011342:IPR022893:IPR013708:IPR006151; KEGG: mmw:Mmwyl1_0070 shikimate 5-dehydrogenase; PFAM: Shikimate dehydrogenase substrate binding, N-terminal; Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase; SPTR: Shikimate dehydrogenase; TIGRFAM: Shikimate dehydrogenase; IMG reference gene:2503956378; PFAM: Shikimate dehydrogenase substrate binding domain; Shikimate / quinate 5-dehydrogenase; TIGRFAM: shikimate 5-dehydrogenase YP_004410739.1 COGs: COG1180 Pyruvate-formate lyase-activating enzyme; InterPro IPR012839:IPR007197; KEGG: ssa:SSA_0277 pyruvate formate-lyase 3, PFAM: Radical SAM; PRIAM: [Formate-C-acetyltransferase]-activating enzyme; SPTR: Pyruvate formate-lyase 3, ; TIGRFAM: Glycyl radical enzyme-activating; IMG reference gene:2503956379; PFAM: Radical SAM superfamily; TIGRFAM: glycyl-radical enzyme activating protein family YP_004410740.1 COGs: COG0705 membrane protein; InterPro IPR022764; KEGG: sta:STHERM_c21730 rhomboid family protein; PFAM: Peptidase S54, rhomboid domain; SPTR: Rhomboid family protein; IMG reference gene:2503956380; PFAM: Rhomboid family YP_004410741.1 COGs: COG1816 Adenosine deaminase; HAMAP: Adenosine deaminase; InterPro IPR006330:IPR001365; KEGG: ssm:Spirs_0300 adenosine deaminase; PFAM: Adenosine/AMP deaminase; PRIAM: Adenosine deaminase; SPTR: Adenosine deaminase; TIGRFAM: Adenosine deaminase; IMG reference gene:2503956381; PFAM: Adenosine/AMP deaminase; TIGRFAM: adenosine deaminase YP_004410742.1 InterPro IPR002110; KEGG: wpi:WPa_1379 ankyrin repeat domain protein; PFAM: Ankyrin repeat; SPTR: FOG: Ankyrin repeat; IMG reference gene:2503956382; PFAM: Ankyrin repeat YP_004410743.1 COGs: COG0442 Prolyl-tRNA synthetase; HAMAP: Prolyl-tRNA synthetase, class IIa, bacterial; InterPro IPR004500:IPR002314:IPR007214:IPR004154; KEGG: stp:Strop_1793 prolyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain; YbaK/aminoacyl-tRNA synthetase-associated domain; Anticodon-binding; SPTR: Prolyl-tRNA synthetase; TIGRFAM: Prolyl-tRNA synthetase, class IIa, bacterial; IMG reference gene:2503956383; PFAM: YbaK / prolyl-tRNA synthetases associated domain; Anticodon binding domain; tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: prolyl-tRNA synthetase, family II YP_004410744.1 COGs: COG0235 Ribulose-5-phosphate 4-epimerase and related epimerase and aldolase; InterPro IPR001303; KEGG: ssm:Spirs_2391 class II aldolase/adducin family protein; PFAM: Class II aldolase/adducin, N-terminal; SPTR: Class II aldolase/adducin family protein; IMG reference gene:2503956384; PFAM: Class II Aldolase and Adducin N-terminal domain YP_004410745.1 COGs: COG3959 Transketolase N-terminal subunit; InterPro IPR005474; KEGG: ssm:Spirs_2992 transketolase domain protein; PFAM: Transketolase, N-terminal; PRIAM: Transketolase; SPTR: Transketolase domain protein; IMG reference gene:2503956385; PFAM: Transketolase, thiamine diphosphate binding domain YP_004410746.1 COGs: COG3958 Transketolase C-terminal subunit; InterPro IPR005475:IPR005476; KEGG: ssm:Spirs_2991 transketolase domain protein; PFAM: Transketolase-like, pyrimidine-binding domain; Transketolase, C-terminal; PRIAM: 1-deoxy-D-xylulose-5-phosphate synthase; SMART: Transketolase-like, pyrimidine-binding domain; SPTR: Transketolase domain protein; IMG reference gene:2503956386; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain YP_004410747.1 KEGG: aag:AaeL_AAEL003101 hypothetical protein; SPTR: Suppression of copper sensitivity: lipoprotein modification in; IMG reference gene:2503956388 YP_004410748.1 COGs: COG1765 redox protein regulator of disulfide bond formation; InterPro IPR003718; KEGG: tsi:TSIB_1698 predicted stress-inducible protein, OsmC/Ohr family; PFAM: Peroxiredoxin, OsmC-like protein; SPTR: uncharacterized protein; IMG reference gene:2503956389; PFAM: OsmC-like protein YP_004410749.1 COGs: COG0173 Aspartyl-tRNA synthetase; InterPro IPR004524:IPR004365:IPR004364:IPR004115; KEGG: ssm:Spirs_0312 aspartyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class II (D/K/N); Nucleic acid binding, OB-fold, tRNA/helicase-type; GAD domain; PRIAM: Aspartate--tRNA ligase; SPTR: Aspartyl-tRNA synthetase; TIGRFAM: Aspartyl-tRNA synthetase, class IIb, bacterial/mitochondrial type; IMG reference gene:2503956390; PFAM: GAD domain; tRNA synthetases class II (D, K and N); OB-fold nucleic acid binding domain; TIGRFAM: aspartyl-tRNA synthetase, bacterial type YP_004410750.1 KEGG: lsg:lse_0723 internalin-like cell wall surface anchor (LPXTG) protein; SPTR: FG-GAP repeat domain protein; IMG reference gene:2503956392 YP_004410751.1 KEGG: lth:KLTH0C00440g KLTH0C00440p; SPTR: Uncharacterized Fe-S protein; IMG reference gene:2503956393 YP_004410752.1 KEGG: lhk:LHK_01554 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956394 YP_004410753.1 KEGG: pdi:BDI_2608 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956396 YP_004410754.1 COGs: COG2865 transcriptional regulator protein; InterPro IPR007421; KEGG: mpe:MYPE2570 hypothetical protein; PFAM: ATPase, AAA-4; SPTR: DNA recombinase RecG; IMG reference gene:2503956397; PFAM: Sugar-specific transcriptional regulator TrmB; Divergent AAA domain YP_004410755.1 KEGG: zpr:ZPR_4496 membrane protein; SPTR: uncharacterized protein; IMG reference gene:2503956399; PFAM: Bacterial protein of unknown function (DUF939) YP_004410756.1 COGs: COG2110 phosphatase homologous to the C-terminal domain of histone macroH2A1; InterPro IPR002589; KEGG: aco:Amico_1593 Appr-1-p processing domain protein; PFAM: Appr-1-p processing; SMART: Appr-1-p processing; SPTR: Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1; IMG reference gene:2503956400; PFAM: Macro domain YP_004410757.1 KEGG: bha:BH1197 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956401 YP_004410758.1 InterPro IPR007168; KEGG: dbr:Deba_2761 phage shock protein C, PspC; PFAM: Phage shock domain; SPTR: phage shock protein C; IMG reference gene:2503956402; PFAM: PspC domain YP_004410759.1 KEGG: gdj:Gdia_0837 methyl-accepting chemotaxis sensory transducer; SPTR: Predicted protein; IMG reference gene:2503956403 YP_004410760.1 COGs: COG1842 Phage shock protein A (IM30) suppresses sigma54-dependent transcription; InterPro IPR007157; KEGG: dde:Dde_3226 phage shock protein A; PFAM: PspA/IM30; SPTR: Phage shock protein A; IMG reference gene:2503956404; PFAM: PspA/IM30 family; TIGRFAM: phage shock protein A YP_004410761.1 COGs: COG3604 Transcriptional regulator containing GAF AAA-type ATPase and DNA binding domains; InterPro IPR014317:IPR002078:IPR003593; KEGG: dbr:Deba_2764 sigma54 specific transcriptional regulator, Fis family; PFAM: RNA polymerase sigma factor 54, interaction; SMART: ATPase, AAA+ type, core; SPTR: Transcriptional regulator, Fis family / DNA-binding protein Fis; TIGRFAM: Transcription activator PspF; IMG reference gene:2503956405; PFAM: Sigma-54 interaction domain; TIGRFAM: psp operon transcriptional activator PspF YP_004410762.1 InterPro IPR007168; KEGG: dma:DMR_38290 hypothetical membrane protein; PFAM: Phage shock domain; SPTR: Phage shock protein C, PspC; IMG reference gene:2503956406; PFAM: PspC domain YP_004410763.1 COGs: COG1842 Phage shock protein A (IM30) suppresses sigma54-dependent transcription; InterPro IPR007157; KEGG: dvm:DvMF_1799 phage shock protein A, PspA; PFAM: PspA/IM30; SPTR: Phage shock protein A, PspA; IMG reference gene:2503956407; PFAM: PspA/IM30 family; TIGRFAM: phage shock protein A YP_004410764.1 COGs: COG0313 methyltransferase; HAMAP: Ribosomal RNA small subunit methyltransferase I; InterPro IPR008189:IPR000878; KEGG: ssm:Spirs_0315 uroporphyrin-III C/tetrapyrrole (corrin/porphyrin) methyltransferase; PFAM: Tetrapyrrole methylase; SPTR: uncharacterized protein; TIGRFAM: Uncharacterised protein family UPF0011; IMG reference gene:2503956408; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: probable S-adenosylmethionine-dependent methyltransferase, YraL family YP_004410765.1 COGs: COG0566 rRNA methylase; InterPro IPR001537; KEGG: ssm:Spirs_0318 tRNA/rRNA methyltransferase (SpoU); PFAM: tRNA/rRNA methyltransferase, SpoU; SPTR: RNA methyltransferase, TrmH family; IMG reference gene:2503956409; PFAM: SpoU rRNA Methylase YP_004410766.1 COGs: COG1067 ATP-dependent protease; KEGG: ssm:Spirs_0321 peptidase S16 lon domain protein; SPTR: uncharacterized protein; manually curated; IMG reference gene:2503956410; PFAM: Lon protease (S16) C-terminal proteolytic domain; TIGRFAM: lon-related ATP-dependent protease YP_004410767.1 COGs: COG0327 conserved hypothetical protein; InterPro IPR002678; KEGG: tde:TDE2208 hypothetical protein; PFAM: NGG1p interacting factor 3, NIF3; SPTR: uncharacterized protein; TIGRFAM: NGG1p interacting factor 3, NIF3; manually curated; IMG reference gene:2503956411; PFAM: NIF3 (NGG1p interacting factor 3); TIGRFAM: dinuclear metal center protein, YbgI/SA1388 family YP_004410768.1 COGs: COG0597 Lipoprotein signal peptidase; HAMAP: Peptidase A8, signal peptidase II; InterPro IPR001872; KEGG: ssm:Spirs_0323 lipoprotein signal peptidase; PFAM: Peptidase A8, signal peptidase II; SPTR: Signal peptidase II; TIGRFAM: Peptidase A8, signal peptidase II; IMG reference gene:2503956412; PFAM: Signal peptidase (SPase) II; TIGRFAM: lipoprotein signal peptidase YP_004410769.1 KEGG: ssm:Spirs_0324 leader peptide processing enzyme; SPTR: uncharacterized protein; IMG reference gene:2503956413 YP_004410770.1 KEGG: lic:LIC11034 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956414 YP_004410771.1 KEGG: fjo:Fjoh_0934 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956415 YP_004410772.1 COGs: COG0657 Esterase/lipase; InterPro IPR013094; KEGG: amr:AM1_0524 lipase/esterase, SPTR: Lipase/esterase, ; IMG reference gene:2503956416; PFAM: alpha/beta hydrolase fold YP_004410773.1 KEGG: taf:THA_161 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956417 YP_004410774.1 COGs: COG2706 3-carboxymuconate cyclase; InterPro IPR003313:IPR000005:IPR019405:IPR018060; KEGG: ssm:Spirs_3785 transcriptional regulator, AraC family; PFAM: Lactonase, 7-bladed beta propeller; HTH transcriptional regulator, AraC, arabinose-binding/dimerisation; HTH transcriptional regulator, AraC; SMART: Helix-turn-helix, AraC type, DNA binding domain; SPTR: 6-phosphogluconolactonase; IMG reference gene:2503956418; PFAM: AraC-like ligand binding domain; Bacterial regulatory helix-turn-helix proteins, AraC family; 3-carboxy-cis,cis-muconate lactonizing enzyme YP_004410775.1 COGs: COG1070 Sugar (pentulose and hexulose) kinase; InterPro IPR006000:IPR018484:IPR018485; KEGG: xca:xccb100_2505 xylulokinase; PFAM: Carbohydrate kinase, FGGY, N-terminal; Carbohydrate kinase, FGGY, C-terminal; SPTR: Xylulokinase; TIGRFAM: Xylulokinase; IMG reference gene:2503956419; PFAM: FGGY family of carbohydrate kinases, N-terminal domain; FGGY family of carbohydrate kinases, C-terminal domain; TIGRFAM: D-xylulose kinase YP_004410776.1 COGs: COG2115 Xylose isomerase; HAMAP: Xylose isomerase; InterPro IPR013452:IPR001998:IPR012307; KEGG: ssm:Spirs_3786 xylose isomerase; PFAM: Xylose isomerase, TIM barrel domain; PRIAM: Xylose isomerase; SPTR: Xylose isomerase 2; TIGRFAM: Xylose isomerase, bacterial type; IMG reference gene:2503956420; PFAM: Xylose isomerase-like TIM barrel; TIGRFAM: xylose isomerase YP_004410777.1 COGs: COG4677 Pectin methylesterase; InterPro IPR000070; KEGG: rmr:Rmar_2469 pectinesterase; PFAM: Pectinesterase, catalytic; PRIAM: Pectinesterase; SPTR: Pectinesterase; IMG reference gene:2503956421; PFAM: Pectinesterase YP_004410778.1 COGs: COG1785 Alkaline phosphatase; InterPro IPR001952; KEGG: avi:Avi_0605 alkaline phosphatase; PFAM: Alkaline phosphatase; SMART: Alkaline phosphatase; SPTR: Alkaline phosphatase; IMG reference gene:2503956422; PFAM: Alkaline phosphatase YP_004410779.1 KEGG: rru:Rru_A1290 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956423 YP_004410780.1 COGs: COG1136 ABC-type antimicrobial peptide transport system ATPase component; InterPro IPR003439:IPR003593; KEGG: pct:PC1_3918 ABC transporter related; PFAM: ABC transporter-like; PRIAM: Phosphonate-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter related; IMG reference gene:2503956424; PFAM: ABC transporter YP_004410781.1 InterPro IPR003838; KEGG: rru:Rru_A1292 hypothetical protein; PFAM: Domain of unknown function DUF214, ABC transporter permease; SPTR: uncharacterized protein; IMG reference gene:2503956425; PFAM: Predicted permease YP_004410782.1 COGs: COG1253 Hemolysins and related protein containing CBS domains; InterPro IPR002550:IPR000644:IPR005170; KEGG: cth:Cthe_2870 hypothetical protein; PFAM: Domain of unknown function DUF21; Cystathionine beta-synthase, core; Transporter-associated domain; SPTR: uncharacterized protein; IMG reference gene:2503956426; PFAM: CBS domain; Domain of unknown function DUF21; Transporter associated domain YP_004410783.1 COGs: COG1392 Phosphate transport regulator (distant homolog of PhoU); InterPro IPR018445; KEGG: cce:Ccel_2118 protein of unknown function DUF47; PFAM: Putitive phosphate transport regulator; SPTR: uncharacterized protein; IMG reference gene:2503956427; PFAM: Protein of unknown function DUF47; TIGRFAM: TIGR00153 family protein YP_004410784.1 COGs: COG0306 Phosphate/sulphate permease; InterPro IPR001204; KEGG: efa:EF2442 phosphate transporter family protein; PFAM: Phosphate transporter; SPTR: Phosphate transporter family protein; IMG reference gene:2503956428; PFAM: Phosphate transporter family YP_004410785.1 COGs: COG2510 membrane protein; InterPro IPR000620; KEGG: cpy:Cphy_2870 hypothetical protein; PFAM: Drug/metabolite transporter; SPTR: uncharacterized protein; IMG reference gene:2503956429; PFAM: EamA-like transporter family YP_004410786.1 KEGG: hor:Hore_08230 WD40 domain protein beta propeller; SPTR: WD40 domain protein beta Propeller; IMG reference gene:2503956430; PFAM: WD40-like Beta Propeller Repeat YP_004410787.1 COGs: COG1937 conserved hypothetical protein; InterPro IPR003735; KEGG: apr:Apre_0988 protein of unknown function DUF156; PFAM: Protein of unknown function DUF156; SPTR: uncharacterized protein; IMG reference gene:2503956431; PFAM: Uncharacterised BCR, COG1937 YP_004410788.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR011110:IPR000408; KEGG: aeh:Mlg_2687 regulator of chromosome condensation, RCC1; PFAM: Regulator of chromosome condensation, RCC1; Two component regulator propeller; SPTR: Alpha-tubulin suppressor and related RCC1 domain-containing protein-like protein; IMG reference gene:2503956432; PFAM: Regulator of chromosome condensation (RCC1) repeat YP_004410789.1 IMG reference gene:2503956433 YP_004410790.1 InterPro IPR002123; KEGG: pgi:PG1876 hypothetical protein; PFAM: Phospholipid/glycerol acyltransferase; SPTR: Acyltransferase; IMG reference gene:2503956434 YP_004410791.1 COGs: COG1132 ABC-type multidrug transport system ATPase and permease components; InterPro IPR001140:IPR003439:IPR003593; KEGG: ppy:PPE_00122 hypothetical ABC transporter ATP-binding protein; PFAM: ABC transporter-like; ABC transporter, transmembrane domain; PRIAM: Xenobiotic-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: Hypothetical ABC transporter ATP-binding protein; IMG reference gene:2503956435; PFAM: ABC transporter; ABC transporter transmembrane region YP_004410792.1 COGs: COG1132 ABC-type multidrug transport system ATPase and permease components; InterPro IPR001140:IPR003439:IPR003593; KEGG: ppy:PPE_00123 ABC-type multidrug transport system protein; PFAM: ABC transporter-like; ABC transporter, transmembrane domain; PRIAM: Xenobiotic-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC-type multidrug transport system protein; IMG reference gene:2503956436; PFAM: ABC transporter; ABC transporter transmembrane region YP_004410793.1 COGs: COG1653 ABC-type sugar transport system periplasmic component; InterPro IPR006059; KEGG: ssm:Spirs_1368 extracellular solute-binding protein family 1; PFAM: Bacterial extracellular solute-binding, family 1; SPTR: Extracellular solute-binding protein family 1; IMG reference gene:2503956437; PFAM: Bacterial extracellular solute-binding protein YP_004410794.1 COGs: COG1175 ABC-type sugar transport systems permease components; InterPro IPR000515; KEGG: ssm:Spirs_1367 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Binding-protein-dependent transport system inner membrane component; IMG reference gene:2503956438; PFAM: Binding-protein-dependent transport system inner membrane component YP_004410795.1 COGs: COG0395 ABC-type sugar transport system permease component; InterPro IPR000515; KEGG: ssm:Spirs_1366 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Binding-protein-dependent transport system inner membrane component; IMG reference gene:2503956439; PFAM: Binding-protein-dependent transport system inner membrane component YP_004410796.1 COGs: COG1011 hydrolase (HAD superfamily); InterPro IPR006402:IPR005834; KEGG: ssm:Spirs_1365 HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase-like hydrolase; SPTR: HAD-superfamily hydrolase, subfamily IA, variant 3; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; IMG reference gene:2503956440; TIGRFAM: haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED YP_004410797.1 COGs: COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain; InterPro IPR001789:IPR000005:IPR018060; KEGG: bcl:ABC3646 two-component response regulator; PFAM: Signal transduction response regulator, receiver domain; HTH transcriptional regulator, AraC; SMART: Helix-turn-helix, AraC type, DNA binding domain; Signal transduction response regulator, receiver domain; SPTR: Two-component response regulator; IMG reference gene:2503956441; PFAM: Response regulator receiver domain; Bacterial regulatory helix-turn-helix proteins, AraC family YP_004410798.1 COGs: COG2972 signal transduction protein with a C-terminal ATPase domain; InterPro IPR003660:IPR010559:IPR003594; KEGG: ssm:Spirs_1363 integral membrane sensor signal transduction histidine kinase; PFAM: Signal transduction histidine kinase, internal region; HAMP linker domain; ATPase-like, ATP-binding domain; SMART: HAMP linker domain; SPTR: Predicted signal transduction protein with a C-terminal ATPase domain; IMG reference gene:2503956442; PFAM: Histidine kinase; HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase YP_004410799.1 KEGG: cth:Cthe_1655 hypothetical protein; SPTR: Predicted transcriptional regulator; IMG reference gene:2503956443 YP_004410800.1 KEGG: prw:PsycPRwf_1121 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956444 YP_004410801.1 InterPro IPR006935:IPR011639:IPR018306:IPR014001; KEGG: spr:spr1101 type II restriction endonuclease, SMART: Bacteriophage T5, ORF172 DNA-binding; DEAD-like helicase, N-terminal; SPTR: uncharacterized protein; IMG reference gene:2503956445; PFAM: SNF2 family N-terminal domain; Eco57I restriction endonuclease YP_004410802.1 COGs: COG3177 conserved hypothetical protein; InterPro IPR003812; KEGG: dsy:DSY0678 hypothetical protein; PFAM: Filamentation induced by cAMP/death on curing-related; SPTR: uncharacterized protein; IMG reference gene:2503956446; PFAM: Fic/DOC family YP_004410803.1 KEGG: dhd:Dhaf_4948 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956447 YP_004410804.1 KEGG: bln:Blon_0974 HipA domain protein; SPTR: HipA-like C-terminal domain; IMG reference gene:2503956448 YP_004410805.1 COGs: COG2026 Cytotoxic translational repressor of toxin-antitoxin stability system; InterPro IPR012753:IPR007712; KEGG: esi:Exig_1264 addiction module antitoxin; PFAM: Plasmid stabilisation system; SPTR: Addiction module toxin RelE; TIGRFAM: Addiction module toxin, RelE/StbE; IMG reference gene:2503956449; PFAM: Plasmid stabilisation system protein; TIGRFAM: addiction module toxin, RelE/StbE family YP_004410806.1 KEGG: fnu:FN1099 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956450; PFAM: Ribbon-helix-helix protein, copG family YP_004410807.1 IMG reference gene:2503956451 YP_004410808.1 IMG reference gene:2503956452 YP_004410809.1 KEGG: bcl:ABC1165 cell surface protein; SPTR: Cell surface protein; IMG reference gene:2503956455 YP_004410810.1 COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR000212; KEGG: bbr:BB4600 ATP-dependent DNA helicase; PFAM: DNA helicase, UvrD/REP type; SPTR: uncharacterized protein; IMG reference gene:2503956456; PFAM: UvrD/REP helicase YP_004410811.1 KEGG: fnu:FN0210 CopG family transcriptional regulator; SPTR: Toxin-antitoxin system protein; IMG reference gene:2503956457 YP_004410812.1 COGs: COG2026 Cytotoxic translational repressor of toxin-antitoxin stability system; InterPro IPR012753:IPR007712; KEGG: esi:Exig_1264 addiction module antitoxin; PFAM: Plasmid stabilisation system; SPTR: uncharacterized protein; TIGRFAM: Addiction module toxin, RelE/StbE; IMG reference gene:2503956458; PFAM: Plasmid stabilisation system protein; TIGRFAM: addiction module toxin, RelE/StbE family YP_004410813.1 COGs: COG3177 conserved hypothetical protein; InterPro IPR003812; KEGG: hmo:HM1_0044 fic family protein, PFAM: Filamentation induced by cAMP/death on curing-related; SPTR: Fic family protein, ; IMG reference gene:2503956459; PFAM: Fic/DOC family YP_004410814.1 KEGG: afn:Acfer_1116 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956460 YP_004410815.1 KEGG: cbr:CBG18870 Hypothetical protein CBG18870; SPTR: uncharacterized protein; IMG reference gene:2503956462 YP_004410816.1 KEGG: ele:Elen_0127 DNA binding domain protein, excisionase; SPTR: uncharacterized protein; IMG reference gene:2503956463; PFAM: HipA-like C-terminal domain YP_004410817.1 IMG reference gene:2503956464 YP_004410818.1 InterPro IPR009241; KEGG: ere:EUBREC_3676 hypothetical protein; PFAM: Protein of unknown function DUF891; SPTR: Toxin-antitoxin system, toxin component, RelE family; IMG reference gene:2503956466; PFAM: Phage derived protein Gp49-like (DUF891) YP_004410819.1 InterPro IPR001387; KEGG: ere:EUBREC_3010 hypothetical protein; PFAM: Helix-turn-helix type 3; SMART: Helix-turn-helix type 3; SPTR: Transcriptional regulator, XRE family; IMG reference gene:2503956467; PFAM: Helix-turn-helix YP_004410820.1 COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR004839; KEGG: ssm:Spirs_1023 aminotransferase class I and II; PFAM: Aminotransferase, class I/classII; SPTR: Aminotransferase class I and II; IMG reference gene:2503956468; PFAM: Aminotransferase class I and II YP_004410821.1 COGs: COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1 7-dioic acid hydratase (catechol pathway); InterPro IPR002529; KEGG: mta:Moth_1492 5-carboxymethyl-2-hydroxymuconate delta-isomerase; PFAM: Fumarylacetoacetase, C-terminal-like; PRIAM: 5-carboxymethyl-2-hydroxymuconate Delta-isomerase; SPTR: 5-carboxymethyl-2-hydroxymuconate Delta-isomerase; IMG reference gene:2503956469; PFAM: Domain of unknown function (DUF2437); Fumarylacetoacetate (FAA) hydrolase YP_004410822.1 COGs: COG1704 conserved hypothetical protein; InterPro IPR007156; KEGG: ddf:DEFDS_1131 hypothetical protein; PFAM: LemA; SPTR: uncharacterized protein; IMG reference gene:2503956470; PFAM: LemA family YP_004410823.1 InterPro IPR018702; KEGG: nde:NIDE3501 hypothetical protein; PFAM: Protein of unknown function DUF2207, membrane; SPTR: uncharacterized protein; IMG reference gene:2503956471; PFAM: Predicted membrane protein (DUF2207) YP_004410824.1 IMG reference gene:2503956472 YP_004410825.1 KEGG: pla:Plav_0415 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956473; PFAM: Protein of unknown function (DUF2804) YP_004410826.1 COGs: COG0724 RNA-binding protein (RRM domain); InterPro IPR000504; KEGG: ssm:Spirs_2330 RNP-1 like RNA-binding protein; PFAM: RNA recognition motif domain; SMART: RNA recognition motif domain; SPTR: RNP-1 like RNA-binding protein; IMG reference gene:2503956474; PFAM: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) YP_004410827.1 InterPro IPR000374; KEGG: acl:ACL_1417 integral membrane protein; PFAM: Phosphatidate cytidylyltransferase; SPTR: Integral membrane protein; IMG reference gene:2503956475; PFAM: Cytidylyltransferase YP_004410828.1 COGs: COG1836 membrane protein; InterPro IPR002794; KEGG: gct:GC56T3_1039 protein of unknown function DUF92 transmembrane; PFAM: Protein of unknown function DUF92, TMEM19; SPTR: uncharacterized protein; IMG reference gene:2503956476; PFAM: Integral membrane protein DUF92; TIGRFAM: TIGR00297 family protein YP_004410829.1 COGs: COG0459 Chaperonin GroEL (HSP60 family); HAMAP: Chaperonin Cpn60; InterPro IPR001844:IPR002423; KEGG: ssm:Spirs_3240 chaperonin GroEL; PFAM: Chaperonin Cpn60/TCP-1; SPTR: 60 kDa chaperonin; TIGRFAM: Chaperonin Cpn60; IMG reference gene:2503956477; PFAM: TCP-1/cpn60 chaperonin family; TIGRFAM: chaperonin GroL YP_004410830.1 COGs: COG1862 Preprotein translocase subunit YajC; InterPro IPR003849; KEGG: ssm:Spirs_3238 preprotein translocase, YajC subunit; PFAM: Preprotein translocase YajC; SPTR: Preprotein translocase, YajC subunit; TIGRFAM: Preprotein translocase YajC; IMG reference gene:2503956478; PFAM: Preprotein translocase subunit; TIGRFAM: preprotein translocase, YajC subunit YP_004410831.1 COGs: COG0342 Preprotein translocase subunit SecD; KEGG: ssm:Spirs_3237 protein-export membrane protein SecD; SPTR: uncharacterized protein; IMG reference gene:2503956479; PFAM: Protein export membrane protein; TIGRFAM: protein-export membrane protein SecD YP_004410832.1 COGs: COG0761 Penicillin tolerance protein; HAMAP: LytB protein; InterPro IPR003451; KEGG: ccu:Ccur_06870 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase; PFAM: LytB protein; PRIAM: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; SPTR: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; TIGRFAM: LytB protein; IMG reference gene:2503956481; PFAM: LytB protein; TIGRFAM: (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming) YP_004410833.1 COGs: COG2344 AT-rich DNA-binding protein; HAMAP: Transcriptional repressor, redox-sensing, Rex; InterPro IPR022876:IPR009718:IPR003781; KEGG: ssm:Spirs_1689 CoA-binding domain protein; PFAM: CoA-binding; Rex DNA-binding, C-terminal; SMART: CoA-binding; SPTR: CoA-binding domain protein; IMG reference gene:2503956482; PFAM: CoA binding domain; DNA-binding protein N-terminus YP_004410834.1 COGs: COG1956 GAF domain-containing protein; InterPro IPR003018; KEGG: bpu:BPUM_2609 hypothetical protein; PFAM: GAF; SPTR: Hypothetical GAF domain protein; IMG reference gene:2503956483; PFAM: GAF domain YP_004410835.1 COGs: COG0441 Threonyl-tRNA synthetase; InterPro IPR002320:IPR012947:IPR002314:IPR004154; KEGG: ssm:Spirs_3229 threonyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain; Threonyl/alanyl tRNA synthetase, SAD; Anticodon-binding; SMART: Threonyl/alanyl tRNA synthetase, SAD; SPTR: Threonyl-tRNA synthetase; TIGRFAM: Threonyl-tRNA synthetase, class IIa; IMG reference gene:2503956484; PFAM: Anticodon binding domain; Threonyl and Alanyl tRNA synthetase second additional domain; tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: threonyl-tRNA synthetase YP_004410836.1 COGs: COG2317 Zn-dependent carboxypeptidase; InterPro IPR001333; KEGG: sta:STHERM_c16020 thermostable carboxypeptidase 1; PFAM: Peptidase M32, carboxypeptidase Taq metallopeptidase; PRIAM: Carboxypeptidase Taq; SPTR: Thermostable carboxypeptidase 1; IMG reference gene:2503956485; PFAM: Carboxypeptidase Taq (M32) metallopeptidase YP_004410837.1 COGs: COG0558 Phosphatidylglycerophosphate synthase; InterPro IPR004570:IPR000462; KEGG: ssm:Spirs_3225 CDP-diacylglycerol/glycerol-3-phosphate3-phospha tidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; SPTR: uncharacterized protein; TIGRFAM: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; IMG reference gene:2503956486; PFAM: CDP-alcohol phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase YP_004410838.1 InterPro IPR006379; KEGG: ssm:Spirs_3224 HAD-superfamily hydrolase, subfamily IIB; SPTR: hydrolase; TIGRFAM: HAD-superfamily hydrolase, subfamily IIB; IMG reference gene:2503956487; TIGRFAM: HAD-superfamily hydrolase, subfamily IIB YP_004410839.1 COGs: COG1108 ABC-type Mn2+/Zn2+ transport systems permease components; InterPro IPR001626; KEGG: dsy:DSY0105 hypothetical protein; PFAM: ABC-3; SPTR: uncharacterized protein; IMG reference gene:2503956492; PFAM: ABC 3 transport family YP_004410840.1 COGs: COG1121 ABC-type Mn/Zn transport systems ATPase component; InterPro IPR003439:IPR003593; KEGG: dhd:Dhaf_0043 ABC transporter related; PFAM: ABC transporter-like; PRIAM: Fe(3+)-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: uncharacterized protein; IMG reference gene:2503956493; PFAM: ABC transporter YP_004410841.1 COGs: COG1135 ABC-type metal ion transport system ATPase component; InterPro IPR003439:IPR018449:IPR003593; KEGG: fsu:Fisuc_1036 ABC transporter related protein; PFAM: ABC transporter-like; NIL domain; PRIAM: Sulfate-transporting ATPase; SMART: ATPase, AAA+ type, core; NIL domain; SPTR: Methionine import ATP-binding protein MetN; IMG reference gene:2503956494; PFAM: ABC transporter; NIL domain YP_004410842.1 COGs: COG2011 ABC-type metal ion transport system permease component; InterPro IPR000515; KEGG: fsu:Fisuc_1035 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: D-methionine transport system permease MetI; IMG reference gene:2503956495; PFAM: Binding-protein-dependent transport system inner membrane component YP_004410843.1 COGs: COG1464 ABC-type metal ion transport system periplasmic component/surface antigen; InterPro IPR004872; KEGG: fsu:Fisuc_1037 NlpA lipoprotein; PFAM: NLPA lipoprotein; SPTR: NLPA lipoprotein; IMG reference gene:2503956496; PFAM: NLPA lipoprotein; TIGRFAM: lipoprotein, YaeC family YP_004410844.1 COGs: COG1322 conserved hypothetical protein; InterPro IPR003798; KEGG: bgl:bglu_1g09340 RmuC domain protein; PFAM: DNA recombination RmuC; SPTR: uncharacterized protein; IMG reference gene:2503956497; PFAM: RmuC family YP_004410845.1 COGs: COG0078 Ornithine carbamoyltransferase; HAMAP: Ornithine carbamoyltransferase; InterPro IPR002292:IPR006132:IPR006131; KEGG: pmo:Pmob_0068 ornithine carbamoyltransferase; PFAM: Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; PRIAM: Ornithine carbamoyltransferase; SPTR: Ornithine carbamoyltransferase; TIGRFAM: Ornithine carbamoyltransferase; IMG reference gene:2503956498; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; TIGRFAM: ornithine carbamoyltransferase YP_004410846.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR011110:IPR000408; KEGG: aeh:Mlg_2687 regulator of chromosome condensation, RCC1; PFAM: Regulator of chromosome condensation, RCC1; Two component regulator propeller; SPTR: Alpha-tubulin suppressor and related RCC1 domain-containing protein-like protein; IMG reference gene:2503956499; PFAM: Regulator of chromosome condensation (RCC1) repeat YP_004410847.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR000408; KEGG: aeh:Mlg_2687 regulator of chromosome condensation, RCC1; PFAM: Regulator of chromosome condensation, RCC1; SPTR: Alpha-tubulin suppressor and related RCC1 domain-containing protein-like protein; IMG reference gene:2503956500; PFAM: Regulator of chromosome condensation (RCC1) repeat YP_004410848.1 COGs: COG0783 DNA-binding ferritin-like protein (oxidative damage protectant); InterPro IPR008331; KEGG: tpp:TPASS_1038 bacterioferrin TpF1; PFAM: Ferritin/Dps protein; SPTR: Antigen TyF1; IMG reference gene:2503956501; PFAM: Ferritin-like domain YP_004410849.1 COGs: COG3604 Transcriptional regulator containing GAF AAA-type ATPase and DNA binding domains; InterPro IPR003018:IPR002078:IPR002197:IPR003593; KEGG: dat:HRM2_00790 FhlA; PFAM: RNA polymerase sigma factor 54, interaction; GAF; Helix-turn-helix, Fis-type; SMART: ATPase, AAA+ type, core; GAF; SPTR: FhlA; IMG reference gene:2503956502; PFAM: GAF domain; Sigma-54 interaction domain YP_004410850.1 COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterProIPR017730:IPR004176:IPR003959:IPR013093:IPR 019489:IPR003593; KEGG: ssm:Spirs_0929 ATP-dependent chaperone ClpB; PFAM: ATPase, AAA-2; ATPase, AAA-type, core; Clp, N-terminal; Clp ATPase, C-terminal; SMART: ATPase, AAA+ type, core; SPTR: ATP-dependent chaperone protein ClpB; TIGRFAM: Chaperonin ClpB; IMG reference gene:2503956503; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; ATPase associated with various cellular activities (AAA); TIGRFAM: ATP-dependent chaperone ClpB YP_004410851.1 COGs: COG1811 Uncharacterized membrane protein possible Na+ channel or pump; InterPro IPR007563; KEGG: brm:Bmur_0947 protein of unknown function DUF554; PFAM: Protein of unknown function DUF554; SPTR: uncharacterized protein; IMG reference gene:2503956504; PFAM: Protein of unknown function (DUF554) YP_004410852.1 COGs: COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylase; InterPro IPR002933:IPR011650; KEGG: mxa:MXAN_2289 hypothetical protein; PFAM: Peptidase M20; Peptidase M20, dimerisation; PRIAM: Gly-Xaa carboxypeptidase; SPTR: Peptidase, M20E (Gly-X carboxypeptidase) subfamily; IMG reference gene:2503956505; PFAM: Peptidase M20/M25/M40; Peptidase dimerisation domain YP_004410853.1 KEGG: cja:CJA_2050 generic methyl-transferase; IMG reference gene:2503956506 YP_004410854.1 InterPro IPR001647; KEGG: cts:Ctha_0156 transcriptional regulator, TetR family; PFAM: Transcription regulator, TetR-like, DNA-binding, bacterial/archaeal; SPTR: Transcriptional regulator, TetR family; IMG reference gene:2503956507; PFAM: Bacterial regulatory proteins, tetR family YP_004410855.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR000408; KEGG: aeh:Mlg_2687 regulator of chromosome condensation, RCC1; PFAM: Regulator of chromosome condensation, RCC1; SPTR: uncharacterized protein; IMG reference gene:2503956508; PFAM: Regulator of chromosome condensation (RCC1) repeat YP_004410856.1 COGs: COG0058 Glucan phosphorylase; InterPro IPR011833:IPR000811; KEGG: ssm:Spirs_0940 glycogen/starch/alpha-glucan phosphorylase; PFAM: Glycosyl transferase, family 35; SPTR: Phosphorylase; TIGRFAM: Glycogen/starch/alpha-glucan phosphorylase; IMG reference gene:2503956509; PFAM: Carbohydrate phosphorylase; TIGRFAM: glycogen/starch/alpha-glucan phosphorylases YP_004410857.1 IMG reference gene:2503956510 YP_004410858.1 KEGG: pan:PODANSg09393 hypothetical protein; IMG reference gene:2503956511 YP_004410859.1 COGs: COG5421 Transposase; InterPro IPR002559; KEGG: cob:COB47_1677 transposase IS4 family protein; PFAM: Transposase, IS4-like; SPTR: Transposase IS4 family protein; IMG reference gene:2503956512; PFAM: Transposase DDE domain YP_004410860.1 InterPro IPR018004; KEGG: dak:DaAHT2_2136 KilA, N-terminal/APSES-type HTH DNA-binding domain protein; PFAM: KilA, N-terminal/APSES-type HTH, DNA-binding; SPTR: KilA domain protein; IMG reference gene:2503956514; PFAM: KilA-N domain YP_004410861.1 KEGG: bca:BCE_0370 hypothetical protein; SPTR: Cytosine-specific methyltransferase; IMG reference gene:2503956515; PFAM: Helix-turn-helix YP_004410862.1 InterPro IPR011639; KEGG: seu:SEQ_0757 modification methylase; PRIAM: Site-specific DNA-methyltransferase (adenine-specific); SPTR: uncharacterized protein; IMG reference gene:2503956516; PFAM: Ribosomal RNA adenine dimethylase; Eco57I restriction endonuclease YP_004410863.1 InterPro IPR009528; KEGG: seu:SEQ_0758 type II restriction enzyme; PFAM: Restriction endonuclease, type II, BsuBI/PstI, C-terminal; PRIAM: Type II site-specific deoxyribonuclease; SPTR: type II restriction enzyme; IMG reference gene:2503956517; PFAM: BsuBI/PstI restriction endonuclease C-terminus YP_004410864.1 InterPro IPR013525; KEGG: tde:TDE0701 hypothetical protein; PFAM: ABC-2 type transporter; SPTR: Membrane protein, ; IMG reference gene:2503956518; PFAM: ABC-2 type transporter YP_004410865.1 COGs: COG1131 ABC-type multidrug transport system ATPase component; InterPro IPR003439:IPR003593; KEGG: tde:TDE0702 ABC transporter, ATP-binding protein; PFAM: ABC transporter-like; PRIAM: Polyamine-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter, ATP-binding protein; IMG reference gene:2503956519; PFAM: ABC transporter YP_004410866.1 InterPro IPR006339:IPR007159; KEGG: tde:TDE0703 AbrB family transcriptional regulator; PFAM: Transcription regulator AbrB/SpoV, predicted; SMART: Transcription regulator AbrB/SpoV, predicted; SPTR: Transcriptional regulator, AbrB family; TIGRFAM: Transcription regulator AbrB; IMG reference gene:2503956520; PFAM: SpoVT / AbrB like domain; TIGRFAM: looped-hinge helix DNA binding domain, AbrB family YP_004410867.1 KEGG: mem:Memar_2263 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956522 YP_004410868.1 KEGG: ccb:Clocel_1507 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956523 YP_004410869.1 InterPro IPR015018; KEGG: sss:SSUSC84_0626 hypothetical protein; PFAM: Protein of unknown function DUF1905; SPTR: uncharacterized protein; IMG reference gene:2503956524; PFAM: Domain of unknown function (DUF1905) YP_004410870.1 COGs: COG2764 conserved hypothetical protein; KEGG: lsp:Bsph_4693 protein PhnB; SPTR: Protein phnB; IMG reference gene:2503956525; PFAM: 3-demethylubiquinone-9 3-methyltransferase YP_004410871.1 COGs: COG2207 AraC-type DNA-binding domain-containing protein; InterPro IPR013096:IPR000005:IPR018060; KEGG: csh:Closa_3990 transcriptional regulator, AraC family; PFAM: HTH transcriptional regulator, AraC; Cupin 2, conserved barrel; SMART: Helix-turn-helix, AraC type, DNA binding domain; SPTR: Transcriptional regulator, AraC/XylS family; IMG reference gene:2503956527; PFAM: Cupin domain; Bacterial regulatory helix-turn-helix proteins, AraC family YP_004410872.1 COGs: COG1653 ABC-type sugar transport system periplasmic component; InterPro IPR006059; KEGG: csh:Closa_3984 extracellular solute-binding protein family 1; PFAM: Bacterial extracellular solute-binding, family 1; SPTR: sugar-binding periplasmic protein; IMG reference gene:2503956528; PFAM: Bacterial extracellular solute-binding protein YP_004410873.1 COGs: COG1175 ABC-type sugar transport systems permease components; InterPro IPR000515; KEGG: csh:Closa_3983 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: ABC-type sugar transport system, permease component; IMG reference gene:2503956529; PFAM: Binding-protein-dependent transport system inner membrane component YP_004410874.1 COGs: COG0395 ABC-type sugar transport system permease component; InterPro IPR000515; KEGG: csh:Closa_3982 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Sugar permease; IMG reference gene:2503956530; PFAM: Binding-protein-dependent transport system inner membrane component YP_004410875.1 KEGG: cai:Caci_0892 tetratricopeptide TPR_4; SPTR: uncharacterized protein; IMG reference gene:2503956531 YP_004410876.1 InterPro IPR002575; KEGG: csh:Closa_3988 aminoglycoside phosphotransferase; PFAM: Aminoglycoside phosphotransferase; SPTR: uncharacterized protein; IMG reference gene:2503956532; PFAM: Phosphotransferase enzyme family YP_004410877.1 KEGG: cpy:Cphy_1854 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956534 YP_004410878.1 COGs: COG0753 Catalase; InterPro IPR018028:IPR010582; KEGG: mla:Mlab_1574 hypothetical protein; PFAM: Catalase-related subgroup; Catalase-related immune responsive; PRIAM: Catalase; SPTR: Catalase; IMG reference gene:2503956535; PFAM: Catalase; Catalase-related immune-responsive YP_004410879.1 COGs: COG1373 ATPase (AAA+ superfamily); KEGG: swo:Swol_0027 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956536 YP_004410880.1 COGs: COG0527 Aspartokinase; InterPro IPR001341:IPR001048; KEGG: ssm:Spirs_0574 aspartate kinase; PFAM: Aspartate/glutamate/uridylate kinase; SPTR: Aspartokinase; TIGRFAM: Aspartate kinase domain; IMG reference gene:2503956537; PFAM: Amino acid kinase; TIGRFAM: aspartate kinase YP_004410881.1 COGs: COG3839 ABC-type sugar transport systems ATPase components; InterPro IPR003439:IPR013611:IPR003593; KEGG: ssm:Spirs_0579 ABC transporter related protein; PFAM: ABC transporter-like; Transport-associated OB, type 2; PRIAM: Glycerol-3-phosphate-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: Sugar ABC transporter; IMG reference gene:2503956538; PFAM: ABC transporter; TOBE domain YP_004410882.1 COGs: COG0252 L-asparaginase/ Glu-tRNAGln amidotransferase subunit D; InterPro IPR006034; KEGG: ade:Adeh_2142 asparaginase; PFAM: Asparaginase/glutaminase; SPTR: Asparaginase; IMG reference gene:2503956539; PFAM: Asparaginase YP_004410883.1 COGs: COG2759 Formyltetrahydrofolate synthetase; HAMAP: Formate-tetrahydrofolate ligase, FTHFS; InterPro IPR000559; KEGG: dhd:Dhaf_0555 formate--tetrahydrofolate ligase; PFAM: Formate-tetrahydrofolate ligase, FTHFS; PRIAM: Formate--tetrahydrofolate ligase; SPTR: Formate--tetrahydrofolate ligase; IMG reference gene:2503956540; PFAM: Formate--tetrahydrofolate ligase YP_004410884.1 COGs: COG1840 ABC-type Fe3+ transport system periplasmic component; InterPro IPR006059; KEGG: kol:Kole_1985 extracellular solute-binding protein family 1; PFAM: Bacterial extracellular solute-binding, family 1; SPTR: Extracellular solute-binding protein family 1; IMG reference gene:2503956542; PFAM: Bacterial extracellular solute-binding protein YP_004410885.1 COGs: COG1178 ABC-type Fe3+ transport system permease component; InterPro IPR000515; KEGG: kol:Kole_1984 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Binding-protein-dependent transport systems inner membrane component; IMG reference gene:2503956543; PFAM: Binding-protein-dependent transport system inner membrane component YP_004410886.1 COGs: COG3842 ABC-type spermidine/putrescine transport systems ATPase components; InterPro IPR003439:IPR013611:IPR003593; KEGG: kol:Kole_1983 ABC transporter related; PFAM: ABC transporter-like; Transport-associated OB, type 2; PRIAM: Polyamine-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC-type spermidine/putrescine transport systems, ATPase components; IMG reference gene:2503956544; PFAM: ABC transporter; TOBE domain YP_004410887.1 InterPro IPR000835; KEGG: csh:Closa_1534 transcriptional regulator, MarR family; PFAM: HTH transcriptional regulator, MarR; SMART: HTH transcriptional regulator, MarR; SPTR: Transcriptional regulator, MarR family; IMG reference gene:2503956545 YP_004410888.1 COGs: COG1233 Phytoene dehydrogenase and related protein; InterPro IPR006076; KEGG: gpb:HDN1F_29420 similar to phytoene dehydrogenase; PFAM: FAD dependent oxidoreductase; SPTR: Phytoene dehydrogenase and related proteins; IMG reference gene:2503956546; PFAM: Flavin containing amine oxidoreductase YP_004410889.1 COGs: COG1022 Long-chain acyl-CoA synthetase (AMP-forming); InterPro IPR000873; KEGG: ssm:Spirs_3695 AMP-dependent synthetase and ligase; PFAM: AMP-dependent synthetase/ligase; PRIAM: Long-chain-fatty-acid--CoA ligase; SPTR: uncharacterized protein; IMG reference gene:2503956547; PFAM: AMP-binding enzyme YP_004410890.1 KEGG: llo:LLO_3092 homologous to SidE substrate of Dot/Icm secretion system; SPTR: Homologous to SidE substrate of Dot/Icm secretion system; IMG reference gene:2503956548 YP_004410891.1 KEGG: ssm:Spirs_1518 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956549 YP_004410892.1 COGs: COG1482 Phosphomannose isomerase; InterPro IPR001250; KEGG: dol:Dole_2015 mannose-6-phosphate isomerase, class I; PFAM: Mannose-6-phosphate isomerase, type I; PRIAM: Mannose-6-phosphate isomerase; SPTR: Mannose-6-phosphate isomerase, class I; TIGRFAM: Mannose-6-phosphate isomerase, type I; IMG reference gene:2503956550; PFAM: Phosphomannose isomerase type I; TIGRFAM: mannose-6-phosphate isomerase, class I YP_004410893.1 COGs: COG0847 DNA polymerase III epsilon subunit and related 3'-5' exonuclease; InterPro IPR006054:IPR013520:IPR006055; KEGG: vpr:Vpar_0406 exonuclease RNase T and DNA polymerase III; PFAM: Exonuclease, RNase T/DNA polymerase III; SMART: Exonuclease; SPTR: Exonuclease; TIGRFAM: DNA polymerase III, epsilon subunit; IMG reference gene:2503956551; PFAM: Exonuclease YP_004410894.1 InterPro IPR000326; KEGG: ssm:Spirs_0904 phosphoesterase PA-phosphatase related protein; PFAM: Phosphatidic acid phosphatase type 2/haloperoxidase; SMART: Phosphatidic acid phosphatase type 2/haloperoxidase; SPTR: Membrane-associated phospholipid phosphatase; IMG reference gene:2503956552; PFAM: PAP2 superfamily YP_004410895.1 COGs: COG0482 tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase contains the PP-loop ATPase domain; HAMAP: tRNA-specific 2-thiouridylase; InterPro IPR004506; KEGG: emi:Emin_0088 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; PFAM: tRNA-specific 2-thiouridylase; SPTR: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; TIGRFAM: tRNA-specific 2-thiouridylase; IMG reference gene:2503956554; PFAM: tRNA methyl transferase; TIGRFAM: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase YP_004410896.1 COGs: COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase; HAMAP: Glucosamine-6-phosphate isomerase; InterPro IPR004547:IPR006148; KEGG: pdi:BDI_3568 glucosamine-6-phosphate deaminase; PFAM: Glucosamine/galactosamine-6-phosphate isomerase; PRIAM: Glucosamine-6-phosphate deaminase; SPTR: Glucosamine-6-phosphate deaminase; TIGRFAM: Glucosamine-6-phosphate isomerase; IMG reference gene:2503956555; PFAM: Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase; TIGRFAM: glucosamine-6-phosphate isomerase YP_004410897.1 COGs: COG0584 Glycerophosphoryl diester phosphodiesterase; InterPro IPR004129; KEGG: dge:Dgeo_1506 glycerophosphoryl diester phosphodiesterase; PFAM: Glycerophosphoryl diester phosphodiesterase; SPTR: Glycerophosphoryl diester phosphodiesterase; IMG reference gene:2503956556; PFAM: Glycerophosphoryl diester phosphodiesterase YP_004410898.1 COGs: COG0565 rRNA methylase; InterPro IPR001537; KEGG: ssm:Spirs_2304 RNA methyltransferase, TrmH family, group 1; PFAM: tRNA/rRNA methyltransferase, SpoU; SPTR: RNA methyltransferase, TrmH family, group 1; IMG reference gene:2503956557; PFAM: SpoU rRNA Methylase; TIGRFAM: RNA methyltransferase, TrmH family, group 1 YP_004410899.1 COGs: COG0628 permease; InterPro IPR002549; KEGG: ssm:Spirs_2291 protein of unknown function UPF0118; PFAM: Uncharacterised protein family UPF0118; SPTR: uncharacterized protein; IMG reference gene:2503956558; PFAM: Domain of unknown function DUF20 YP_004410900.1 COGs: COG1194 A/G-specific DNA glycosylase; InterPro IPR003265; KEGG: mem:Memar_1721 HhH-GPD family protein; PFAM: HhH-GPD domain; SMART: HhH-GPD domain; SPTR: HhH-GPD family protein; IMG reference gene:2503956559; PFAM: HhH-GPD superfamily base excision DNA repair protein; Helix-hairpin-helix motif YP_004410901.1 InterPro IPR006750; KEGG: cpy:Cphy_1299 hypothetical protein; PFAM: Protein of unknown function DUF606; SPTR: uncharacterized protein; IMG reference gene:2503956560; PFAM: Protein of unknown function, DUF606 YP_004410902.1 COGs: COG0560 Phosphoserine phosphatase; InterPro IPR011863:IPR005834; KEGG: sta:STHERM_c21790 hypothetical protein; PFAM: Haloacid dehalogenase-like hydrolase; SPTR: uncharacterized protein; TIGRFAM: Phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; IMG reference gene:2503956561; TIGRFAM: phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein YP_004410903.1 COGs: COG1734 DnaK suppressor protein; InterPro IPR000962; KEGG: ssm:Spirs_0464 transcriptional regulator, TraR/DksA family; SPTR: C4 zinc finger domain protein, DksA/TraR family; IMG reference gene:2503956562; PFAM: Prokaryotic dksA/traR C4-type zinc finger YP_004410904.1 COGs: COG0491 Zn-dependent hydrolase including glyoxylase; InterPro IPR001279; KEGG: gka:GK2439 hypothetical protein; PFAM: Beta-lactamase-like; SMART: Beta-lactamase-like; SPTR: Beta-lactamase domain protein; IMG reference gene:2503956563; PFAM: Metallo-beta-lactamase superfamily YP_004410905.1 InterPro IPR005580; KEGG: ssm:Spirs_0468 DbpA RNA-binding domain protein; PFAM: DbpA, RNA-binding; SPTR: DbpA RNA binding domain protein; IMG reference gene:2503956564; PFAM: DbpA RNA binding domain YP_004410906.1 KEGG: ssm:Spirs_0472 hypothetical protein; SPTR: Chromosome assembly protein homolog; IMG reference gene:2503956565 YP_004410907.1 COGs: COG1559 periplasmic solute-binding protein; InterPro IPR003770; KEGG: msv:Mesil_0225 aminodeoxychorismate lyase; PFAM: Uncharacterised protein family UPF0755; SPTR: Aminodeoxychorismate lyase; TIGRFAM: Uncharacterised protein family UPF0755; IMG reference gene:2503956566; PFAM: YceG-like family; TIGRFAM: conserved hypothetical protein, YceG family YP_004410908.1 COGs: COG3315 O-Methyltransferase involved in polyketide biosynthesis; KEGG: ols:Olsu_0657 tetracenomycin polyketide synthesis O-methyltransferase TcmP; SPTR: uncharacterized protein; IMG reference gene:2503956567; PFAM: Leucine carboxyl methyltransferase YP_004410909.1 COGs: COG1752 esterase of the alpha-beta hydrolase superfamily; InterPro IPR002641; KEGG: fjo:Fjoh_0727 patatin; PFAM: Patatin/Phospholipase A2-related; SPTR: patatin-like phospholipase; IMG reference gene:2503956569; PFAM: Patatin-like phospholipase YP_004410910.1 COGs: COG1636 conserved hypothetical protein; InterPro IPR003828; KEGG: ssm:Spirs_2754 protein of unknown function DUF208; PFAM: Protein of unknown function DUF208; SPTR: uncharacterized protein; IMG reference gene:2503956570; PFAM: Uncharacterized BCR, COG1636 YP_004410911.1 KEGG: ccb:Clocel_0599 TPR repeat-containing protein; SPTR: TPR repeat-containing protein; IMG reference gene:2503956571 YP_004410912.1 COGs: COG1502 Phosphatidylserine/phosphatidylglycerophosphate/ cardiolipin synthase; InterPro IPR001736; KEGG: cpe:CPE0365 cardiolipin synthetase; PFAM: Phospholipase D/Transphosphatidylase; SMART: Phospholipase D/Transphosphatidylase; SPTR: uncharacterized protein; IMG reference gene:2503956572; PFAM: Phospholipase D Active site motif YP_004410913.1 COGs: COG1814 Uncharacterized membrane protein; InterPro IPR008217; KEGG: brm:Bmur_1173 protein of unknown function DUF125 transmembrane; PFAM: Domain of unknown function DUF125, transmembrane; SPTR: uncharacterized protein; IMG reference gene:2503956573; PFAM: VIT family YP_004410914.1 InterPro IPR000831; KEGG: sta:STHERM_c18770 hypothetical protein; PFAM: Trp repressor; SPTR: uncharacterized protein; IMG reference gene:2503956574; PFAM: Trp repressor protein; TIGRFAM: trp operon repressor, proteobacterial YP_004410915.1 InterPro IPR005242; KEGG: cpy:Cphy_1959 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956575; PFAM: Uncharacterised protein family (UPF0104); TIGRFAM: conserved hypothetical protein YP_004410916.1 COGs: COG0438 Glycosyltransferase; InterPro IPR001296; KEGG: bfs:BF3235 glycosyl transferase; PFAM: Glycosyl transferase, group 1; SPTR: uncharacterized protein; IMG reference gene:2503956576; PFAM: Glycosyl transferases group 1 YP_004410917.1 COGs: COG0513 Superfamily II DNA and RNA helicase; InterPro IPR011545:IPR001650:IPR014001; KEGG: mba:Mbar_A0145 ATP-dependent RNA helicase; PFAM: DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Helicase, C-terminal; SMART: DEAD-like helicase, N-terminal; Helicase, C-terminal; SPTR: ATP-dependent RNA helicase; IMG reference gene:2503956577; PFAM: Helicase conserved C-terminal domain; DEAD/DEAH box helicase YP_004410918.1 KEGG: tde:TDE1337 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956578; PFAM: Protein of unknown function (DUF2804) YP_004410919.1 InterPro IPR000297; KEGG: ssm:Spirs_1830 PpiC-type peptidyl-prolyl cis-trans isomerase; PFAM: Peptidyl-prolyl cis-trans isomerase, PpiC-type; SPTR: uncharacterized protein; IMG reference gene:2503956579; PFAM: PPIC-type PPIASE domain YP_004410920.1 KEGG: dhd:Dhaf_0871 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956580 YP_004410921.1 KEGG: vcn:VOLCADRAFT_103453 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956582 YP_004410922.1 COGs: COG1840 ABC-type Fe3+ transport system periplasmic component; InterPro IPR006059; KEGG: aco:Amico_1577 extracellular solute-binding protein family 1; PFAM: Bacterial extracellular solute-binding, family 1; SPTR: ABC transporter, periplasmic binding protein, thiB subfamily; IMG reference gene:2503956583; PFAM: Bacterial extracellular solute-binding protein YP_004410923.1 COGs: COG1178 ABC-type Fe3+ transport system permease component; InterPro IPR000515; KEGG: aco:Amico_1576 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Binding-protein-dependent transport systems inner membrane component; IMG reference gene:2503956584; PFAM: Binding-protein-dependent transport system inner membrane component YP_004410924.1 COGs: COG3842 ABC-type spermidine/putrescine transport systems ATPase components; InterPro IPR003439:IPR013611:IPR003593; KEGG: csh:Closa_0645 ABC transporter related protein; PFAM: ABC transporter-like; Transport-associated OB, type 2; PRIAM: Polyamine-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter related protein; IMG reference gene:2503956585; PFAM: ABC transporter; TOBE domain YP_004410925.1 COGs: COG0657 Esterase/lipase; KEGG: pjd:Pjdr2_5261 pectin acetylesterase; SPTR: Endo-1,4-beta-xylanase B; IMG reference gene:2503956586; PFAM: Prolyl oligopeptidase; alpha/beta hydrolase fold YP_004410926.1 KEGG: acl:ACL_0438 Fic-domain-containing protein; SPTR: Fic-domain containing protein; IMG reference gene:2503956587 YP_004410927.1 COGs: COG1126 ABC-type polar amino acid transport system ATPase component; InterPro IPR003439:IPR003593; KEGG: ele:Elen_0663 ABC transporter related; PFAM: ABC transporter-like; PRIAM: Fe(3+)-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: Amino acid ABC transporter ATP-binding protein, PAAT family (TC 3.A.1.3.-); IMG reference gene:2503956588; PFAM: ABC transporter YP_004410928.1 COGs: COG0765 ABC-type amino acid transport system permease component; InterPro IPR000515:IPR010065; KEGG: tjr:TherJR_0418 polar amino acid ABC transporter, inner membrane subunit; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Polar amino acid ABC transporter, inner membrane subunit; TIGRFAM: Amino acid ABC transporter, permease, 3-TM domain, His/Glu/Gln/Arg/opine family; IMG reference gene:2503956589; PFAM: Binding-protein-dependent transport system inner membrane component; TIGRFAM: amine acid ABC transporter, permease, 3-TM region, His/Glu/Gln/Arg/opine family YP_004410929.1 COGs: COG0834 ABC-type amino acid transport/signal transduction systems periplasmic component/domain; InterPro IPR001638; KEGG: tjr:TherJR_0419 extracellular solute-binding protein family 3; PFAM: Extracellular solute-binding protein, family 3; SMART: Extracellular solute-binding protein, family 3; SPTR: Extracellular solute-binding protein family 3; IMG reference gene:2503956590; PFAM: Bacterial extracellular solute-binding proteins, family 3 YP_004410930.1 COGs: COG1883 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase beta subunit; InterPro IPR005661; KEGG: csh:Closa_2394 sodium ion-translocating decarboxylase, beta subunit; PFAM: Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit; PRIAM: Oxaloacetate decarboxylase; SPTR: Oxaloacetate decarboxylase, beta subunit; TIGRFAM: Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit; IMG reference gene:2503956591; PFAM: subunit; TIGRFAM: sodium ion-translocating decarboxylase, beta subunit YP_004410931.1 InterPro IPR005899; PFAM: Sodium ion-translocating decarboxylase; SPTR: uncharacterized protein; IMG reference gene:2503956592; PFAM: Oxaloacetate decarboxylase, gamma chain YP_004410932.1 COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR002912:IPR019455:IPR004789; KEGG: cth:Cthe_2517 acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT; SPTR: Acetolactate synthase, small subunit; TIGRFAM: Acetolactate synthase, small subunit; IMG reference gene:2503956593; PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit YP_004410933.1 COGs: COG0059 Ketol-acid reductoisomerase; HAMAP: Acetohydroxy acid isomeroreductase; InterPro IPR013023:IPR013116:IPR000506; KEGG: ccb:Clocel_1325 ketol-acid reductoisomerase; PFAM: Acetohydroxy acid isomeroreductase, catalytic; Acetohydroxy acid isomeroreductase C-terminal; PRIAM: Ketol-acid reductoisomerase; SPTR: Ketol-acid reductoisomerase; TIGRFAM: Acetohydroxy acid isomeroreductase; IMG reference gene:2503956594; PFAM: Acetohydroxy acid isomeroreductase, catalytic domain; TIGRFAM: ketol-acid reductoisomerase YP_004410934.1 COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891:IPR013709:IPR005671; KEGG: amt:Amet_3458 2-isopropylmalate synthase; PFAM: Pyruvate carboxyltransferase; 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; PRIAM: 2-isopropylmalate synthase; SMART: 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; SPTR: 2-isopropylmalate synthase; TIGRFAM: 2-isopropylmalate synthase, bacterial type; IMG reference gene:2503956595; PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; TIGRFAM: 2-isopropylmalate synthase, bacterial type YP_004410935.1 COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891:IPR013709:IPR005675; KEGG: ccb:Clocel_1321 2-isopropylmalate synthase/homocitrate synthase; PFAM: Pyruvate carboxyltransferase; 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; PRIAM: (R)-citramalate synthase; SMART: 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; SPTR: 2-isopropylmalate synthase/homocitrate synthase; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase-related; IMG reference gene:2503956596; PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase YP_004410936.1 COGs: COG0065 3-isopropylmalate dehydratase large subunit; HAMAP: Homoaconitase/3-isopropylmalate dehydratase, large subunit, prokaryotic; InterPro IPR011826:IPR001030:IPR011823:IPR006251; KEGG: ckl:CKL_2159 3-isopropylmalate dehydratase large subunit; PFAM: Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha; SPTR: 3-isopropylmalate dehydratase large subunit; TIGRFAM: 3-isopropylmalate dehydratase, large subunit, prokaryotic; Homoaconitase/3-isopropylmalate dehydratase, large subunit, prokaryotic; Homoaconitase/3-isopropylmalate dehydratase, large subunit, subgroup; IMG reference gene:2503956597; PFAM: Aconitase (aconitate hydratase); TIGRFAM: 3-isopropylmalate dehydratase, large subunit; homoaconitate hydratase YP_004410937.1 COGs: COG0066 3-isopropylmalate dehydratase small subunit; HAMAP: 3-isopropylmalate dehydratase small subunit; InterPro IPR000573:IPR011824:IPR011827; KEGG: ere:EUBREC_1995 3-isopropylmalate dehydratase small subunit; PFAM: Aconitase A/isopropylmalate dehydratase small subunit, swivel; PRIAM: (R)-2-methylmalate dehydratase; SPTR: 3-isopropylmalate dehydratase, small subunit; TIGRFAM: 3-isopropylmalate dehydratase, small subunit, bacterial-like; 3-isopropylmalate dehydratase, small subunit, subgroup; IMG reference gene:2503956598; PFAM: Aconitase C-terminal domain; TIGRFAM: 3-isopropylmalate dehydratase, small subunit YP_004410938.1 COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; HAMAP: Isopropylmalate dehydrogenase; InterPro IPR004429:IPR001804; KEGG: cbe:Cbei_0216 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; PRIAM: 3-isopropylmalate dehydrogenase; SPTR: 3-isopropylmalate dehydrogenase; TIGRFAM: Isopropylmalate dehydrogenase; IMG reference gene:2503956599; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: 3-isopropylmalate dehydrogenase YP_004410939.1 COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; HAMAP: Dihydroxy-acid dehydratase; InterPro IPR004404:IPR000581; KEGG: amt:Amet_3401 dihydroxy-acid dehydratase; PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: Dihydroxy-acid dehydratase; TIGRFAM: Dihydroxy-acid dehydratase; IMG reference gene:2503956600; PFAM: Dehydratase; TIGRFAM: dihydroxy-acid dehydratase YP_004410940.1 COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012001:IPR012000:IPR011766:IPR012846; KEGG: cpy:Cphy_3347 acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding; PRIAM: Acetolactate synthase; SPTR: Acetolactate synthase; TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; IMG reference gene:2503956601; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type YP_004410941.1 InterPro IPR011435; KEGG: eel:EUBELI_01841 hypothetical protein; PFAM: Protein of unknown function DUF1538; SPTR: uncharacterized protein; IMG reference gene:2503956602; PFAM: Protein of unknown function (DUF1538) YP_004410942.1 InterPro IPR011701; KEGG: cno:NT01CX_1080 major facilitator superfamily protein; PFAM: Major facilitator superfamily MFS-1; SPTR: Major facilitator superfamily protein; IMG reference gene:2503956603; PFAM: Major Facilitator Superfamily YP_004410943.1 COGs: COG0561 hydrolase of the HAD superfamily; InterPro IPR013200:IPR000150:IPR006379; KEGG: cbe:Cbei_0458 Cof-like hydrolase; PFAM: HAD superfamily hydrolase-like, type 3; SPTR: Cof-like hydrolase; TIGRFAM: Cof protein; HAD-superfamily hydrolase, subfamily IIB; IMG reference gene:2503956604; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; HAD-superfamily hydrolase, subfamily IIB YP_004410944.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR013378:IPR011110:IPR000408; KEGG: aeh:Mlg_2687 regulator of chromosome condensation, RCC1; PFAM: Listeria/Bacterioides repeat; Two component regulator propeller; Regulator of chromosome condensation, RCC1; SPTR: uncharacterized protein; TIGRFAM: Listeria/Bacterioides repeat; IMG reference gene:2503956605; PFAM: Listeria-Bacteroides repeat domain (List_Bact_rpt); Regulator of chromosome condensation (RCC1) repeat; TIGRFAM: Listeria/Bacterioides repeat YP_004410945.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR013378:IPR011110:IPR000408; KEGG: aeh:Mlg_2687 regulator of chromosome condensation, RCC1; PFAM: Listeria/Bacterioides repeat; Two component regulator propeller; Regulator of chromosome condensation, RCC1; SPTR: uncharacterized protein; IMG reference gene:2503956606; PFAM: Listeria-Bacteroides repeat domain (List_Bact_rpt); Regulator of chromosome condensation (RCC1) repeat YP_004410946.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR013378:IPR000408; KEGG: ttm:Tthe_2617 S-layer domain protein; PFAM: Listeria/Bacterioides repeat; Regulator of chromosome condensation, RCC1; SPTR: Alpha-tubulin suppressor and related RCC1 domain-containing protein-like protein; IMG reference gene:2503956607; PFAM: Listeria-Bacteroides repeat domain (List_Bact_rpt); Regulator of chromosome condensation (RCC1) repeat YP_004410947.1 COGs: COG1879 ABC-type sugar transport system periplasmic component; InterPro IPR001761; KEGG: ssm:Spirs_3421 periplasmic binding protein/LacI transcriptional regulator; PFAM: Periplasmic binding protein/LacI transcriptional regulator; SPTR: Periplasmic binding protein/LacI transcriptional regulator; IMG reference gene:2503956608; PFAM: family YP_004410948.1 COGs: COG1129 ABC-type sugar transport system ATPase component; InterPro IPR003439:IPR003593; KEGG: ssm:Spirs_3420 ABC transporter related protein; PFAM: ABC transporter-like; PRIAM: Monosaccharide-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter related protein; IMG reference gene:2503956609; PFAM: ABC transporter YP_004410949.1 COGs: COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems permease components; InterPro IPR001851; KEGG: ssm:Spirs_3419 inner-membrane translocator; PFAM: ABC transporter permease; SPTR: Inner-membrane translocator; IMG reference gene:2503956610; PFAM: Branched-chain amino acid transport system / permease component YP_004410950.1 COGs: COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems permease components; InterPro IPR001851; KEGG: ssm:Spirs_3418 inner-membrane translocator; PFAM: ABC transporter permease; SPTR: Inner-membrane translocator; IMG reference gene:2503956611; PFAM: Branched-chain amino acid transport system / permease component YP_004410951.1 COGs: COG1070 Sugar (pentulose and hexulose) kinase; InterPro IPR018484; KEGG: csh:Closa_0680 ATPase BadF/BadG/BcrA/BcrD type; PFAM: Carbohydrate kinase, FGGY, N-terminal; SPTR: Sugar (Pentulose and hexulose) kinases; IMG reference gene:2503956612; PFAM: FGGY family of carbohydrate kinases, N-terminal domain; FGGY family of carbohydrate kinases, C-terminal domain YP_004410952.1 COGs: COG3534 Alpha-L-arabinofuranosidase; InterPro IPR010720; KEGG: sta:STHERM_c14770 alpha-N-arabinofuranosidase; PFAM: Alpha-L-arabinofuranosidase, C-terminal; PRIAM: Alpha-N-arabinofuranosidase; SMART: Alpha-L-arabinofuranosidase, C-terminal; SPTR: Alpha-N-arabinofuranosidase; IMG reference gene:2503956613; PFAM: Alpha-L-arabinofuranosidase C-terminus YP_004410953.1 COGs: COG1609 Transcriptional regulators; InterPro IPR000843; KEGG: sta:STHERM_c20570 transcriptional regulatory protein; PFAM: HTH transcriptional regulator, LacI; SMART: HTH transcriptional regulator, LacI; SPTR: Transcriptional regulatory protein; IMG reference gene:2503956614; PFAM: Bacterial regulatory proteins, lacI family; family YP_004410954.1 COGs: COG2160 L-arabinose isomerase; HAMAP: L-arabinose isomerase; InterPro IPR003762; KEGG: ccb:Clocel_1254 L-arabinose isomerase; PFAM: L-arabinose isomerase; PRIAM: L-arabinose isomerase; SPTR: uncharacterized protein; IMG reference gene:2503956615; PFAM: L-arabinose isomerase; L-arabinose isomerase C-terminal domain YP_004410955.1 COGs: COG0235 Ribulose-5-phosphate 4-epimerase and related epimerase and aldolase; InterPro IPR001303; KEGG: cpf:CPF_0648 L-ribulose-5-phosphate 4-epimerase; PFAM: Class II aldolase/adducin, N-terminal; PRIAM: L-ribulose-5-phosphate 4-epimerase; SPTR: L-ribulose-5-phosphate 4-epimerase; IMG reference gene:2503956616; PFAM: Class II Aldolase and Adducin N-terminal domain; TIGRFAM: L-ribulose-5-phosphate 4-epimerase YP_004410956.1 COGs: COG1454 Alcohol dehydrogenase class IV; InterPro IPR015590:IPR001670; KEGG: cyj:Cyan7822_1604 iron-containing alcohol dehydrogenase; PFAM: Alcohol dehydrogenase, iron-type; Aldehyde dehydrogenase domain; PRIAM: Acetaldehyde dehydrogenase (acetylating); SPTR: Iron-containing alcohol dehydrogenase; IMG reference gene:2503956617; PFAM: Aldehyde dehydrogenase; Iron-containing alcohol dehydrogenase YP_004410957.1 COGs: COG4769 membrane protein; InterPro IPR010898; KEGG: tde:TDE1926 hypothetical protein; PFAM: Heptaprenyl diphosphate synthase component I; SPTR: Membrane protein, ; IMG reference gene:2503956618; PFAM: Heptaprenyl diphosphate synthase component I YP_004410958.1 COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789:IPR001867; KEGG: ssm:Spirs_2695 two component transcriptional regulator, winged helix family; PFAM: Signal transduction response regulator, receiver domain; Signal transduction response regulator, C-terminal; SMART: Signal transduction response regulator, receiver domain; Signal transduction response regulator, C-terminal; SPTR: Transcriptional regulatory protein; IMG reference gene:2503956619; PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal YP_004410959.1 COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789:IPR001867; KEGG: ssm:Spirs_2695 two component transcriptional regulator, winged helix family; PFAM: Signal transduction response regulator, receiver domain; Signal transduction response regulator, C-terminal; SMART: Signal transduction response regulator, receiver domain; Signal transduction response regulator, C-terminal; SPTR: Transcriptional regulatory protein; IMG reference gene:2503956620; PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal YP_004410960.1 COGs: COG0642 Signal transduction histidine kinase; InterPro IPR003661:IPR003594; KEGG: bcv:Bcav_1275 histidine kinase; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; SMART: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; SPTR: Histidine kinase; IMG reference gene:2503956621; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain YP_004410961.1 COGs: COG0469 Pyruvate kinase; InterPro IPR015793:IPR015795:IPR001697; KEGG: cob:COB47_1291 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, C-terminal-like; PRIAM: Pyruvate kinase; SPTR: Pyruvate kinase; TIGRFAM: Pyruvate kinase; IMG reference gene:2503956622; PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase YP_004410962.1 COGs: COG1053 Succinate dehydrogenase/fumarate reductase flavoprotein subunit; InterPro IPR007329:IPR003953:IPR010960; KEGG: ssm:Spirs_3607 flavocytochrome c; PFAM: Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal; FMN-binding; PRIAM: Succinate dehydrogenase; SMART: FMN-binding; SPTR: Flavocytochrome c; TIGRFAM: Flavocytochrome c; IMG reference gene:2503956623; PFAM: FAD binding domain; FMN-binding domain; TIGRFAM: flavocytochrome c YP_004410963.1 COGs: COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems periplasmic components; KEGG: dhd:Dhaf_2612 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956624; PFAM: NMT1/THI5 like YP_004410964.1 COGs: COG0600 ABC-type nitrate/sulfonate/bicarbonate transport system permease component; InterPro IPR000515; KEGG: dhd:Dhaf_2613 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Binding-protein-dependent transport system inner membrane component; IMG reference gene:2503956625; PFAM: Binding-protein-dependent transport system inner membrane component YP_004410965.1 COGs: COG1116 ABC-type nitrate/sulfonate/bicarbonate transport system ATPase component; InterPro IPR003439:IPR003593; KEGG: dsa:Desal_1874 ABC transporter related; PFAM: ABC transporter-like; PRIAM: Fe(3+)-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: uncharacterized protein; IMG reference gene:2503956626; PFAM: ABC transporter YP_004410966.1 COGs: COG4624 Iron only hydrogenase large subunit C-terminal domain; InterProIPR001041:IPR019574:IPR001450:IPR004108:IPR 003149:IPR013352; KEGG: cbt:CLH_1644 iron hydrogenase 1; PFAM: Iron hydrogenase, large subunit, C-terminal; NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding; Ferredoxin; 4Fe-4S binding domain; Iron hydrogenase, small subunit-like; PRIAM: Ferredoxin hydrogenase; SMART: Iron hydrogenase, small subunit-like; NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding; SPTR: Hydrogenase, Fe-only; TIGRFAM: Iron hydrogenase, subset; IMG reference gene:2503956627; PFAM: 2Fe-2S iron-sulfur cluster binding domain; Iron only hydrogenase large subunit, C-terminal domain; NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Iron hydrogenase small subunit; TIGRFAM: hydrogenase, Fe-only YP_004410967.1 COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR019575:IPR013027; KEGG: cbt:CLH_1645 glutamate synthase (NADPH) small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding; PRIAM: Glutamate synthase (NADPH); SMART: NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding; SPTR: NADH ubiquinone oxidoreductase, F subunit, iron sulfur binding; IMG reference gene:2503956628; PFAM: NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Pyridine nucleotide-disulphide oxidoreductase YP_004410968.1 COGs: COG5523 integral membrane protein; InterPro IPR010380; KEGG: clj:CLJU_c32220 hypothetical protein; PFAM: Protein of unknown function DUF975; SPTR: uncharacterized protein; IMG reference gene:2503956629; PFAM: Protein of unknown function (DUF975) YP_004410969.1 COGs: COG2094 3-methyladenine DNA glycosylase; HAMAP: Methylpurine-DNA glycosylase (MPG); InterPro IPR003180; KEGG: dsy:DSY3705 3-methyladenine DNA glycosylase; PFAM: Methylpurine-DNA glycosylase (MPG); PRIAM: DNA-3-methyladenine glycosylase II; SPTR: 3-methyladenine DNA glycosylase; TIGRFAM: Methylpurine-DNA glycosylase (MPG); IMG reference gene:2503956631; PFAM: Methylpurine-DNA glycosylase (MPG); TIGRFAM: DNA-3-methyladenine glycosylase (3mg) YP_004410970.1 COGs: COG2207 AraC-type DNA-binding domain-containing protein; InterPro IPR000005:IPR018060; KEGG: cob:COB47_1803 transcriptional regulator, AraC family; PFAM: HTH transcriptional regulator, AraC; SMART: Helix-turn-helix, AraC type, DNA binding domain; SPTR: Transcriptional regulator, AraC family; IMG reference gene:2503956632; PFAM: Bacterial regulatory helix-turn-helix proteins, AraC family YP_004410971.1 KEGG: caa:Caka_1364 redoxin domain protein; SPTR: Redoxin domain protein; IMG reference gene:2503956633; PFAM: AhpC/TSA family YP_004410972.1 COGs: COG3119 Arylsulfatase A; InterPro IPR000917; KEGG: fbc:FB2170_02130 arylsulfatase A precursor; PFAM: Sulfatase; SPTR: Arylsulfatase A; IMG reference gene:2503956634; PFAM: Sulfatase YP_004410973.1 COGs: COG1653 ABC-type sugar transport system periplasmic component; InterPro IPR006059; KEGG: gym:GYMC10_2944 extracellular solute-binding protein family 1; PFAM: Bacterial extracellular solute-binding, family 1; SPTR: Extracellular solute-binding protein family 1; IMG reference gene:2503956635; PFAM: Bacterial extracellular solute-binding protein YP_004410974.1 COGs: COG0395 ABC-type sugar transport system permease component; InterPro IPR000515; KEGG: gym:GYMC10_1004 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Binding-protein-dependent transport systems inner membrane component; IMG reference gene:2503956636 YP_004410975.1 COGs: COG4209 ABC-type polysaccharide transport system permease component; InterPro IPR000515; KEGG: gym:GYMC10_3277 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Binding-protein-dependent transport systems inner membrane component; manually curated; IMG reference gene:2503956637; PFAM: Binding-protein-dependent transport system inner membrane component YP_004410976.1 COGs: COG3669 Alpha-L-fucosidase; InterPro IPR000933; KEGG: tde:TDE0480 alpha-L-fucosidase; PFAM: Glycoside hydrolase, family 29; SMART: Glycoside hydrolase, family 29; SPTR: Alpha-L-fucosidase; IMG reference gene:2503956638; PFAM: Alpha-L-fucosidase YP_004410977.1 COGs: COG3119 Arylsulfatase A; InterPro IPR000917; KEGG: caa:Caka_0229 sulfatase; PFAM: Sulfatase; SPTR: uncharacterized protein; IMG reference gene:2503956639; PFAM: Sulfatase YP_004410978.1 KEGG: bfo:BRAFLDRAFT_80969 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956641 YP_004410979.1 COGs: COG2832 conserved hypothetical protein; InterPro IPR007401; KEGG: hch:HCH_04406 hypothetical protein; PFAM: Protein of unknown function DUF454; SPTR: Uncharacterized protein conserved in bacteria; IMG reference gene:2503956642; PFAM: Protein of unknown function (DUF454) YP_004410980.1 InterPro IPR011701; KEGG: dhd:Dhaf_2526 H+ antiporter protein; PFAM: Major facilitator superfamily MFS-1; SPTR: uncharacterized protein; IMG reference gene:2503956643; PFAM: Major Facilitator Superfamily YP_004410981.1 InterPro IPR006121; KEGG: mmh:Mmah_1006 heavy metal translocating P-type ATPase; PFAM: Heavy metal transport/detoxification protein; SPTR: Heavy metal transport/detoxification protein; IMG reference gene:2503956644; PFAM: Heavy-metal-associated domain YP_004410982.1 COGs: COG2217 Cation transport ATPase; InterProIPR006121:IPR008250:IPR005834:IPR006403:IPR 006416:IPR001757; KEGG: brm:Bmur_1532 heavy metal translocating P-type ATPase; PFAM: ATPase, P-type, ATPase-associated domain; Heavy metal transport/detoxification protein; Haloacid dehalogenase-like hydrolase; PRIAM: Copper-exporting ATPase; SPTR: Heavy metal translocating P-type ATPase; TIGRFAM: ATPase, P-type, heavy metal translocating; ATPase, P type, cation/copper-transporter; ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter; IMG reference gene:2503956645; PFAM: E1-E2 ATPase; Heavy-metal-associated domain; haloacid dehalogenase-like hydrolase; TIGRFAM: copper-(or silver)-translocating P-type ATPase; heavy metal translocating P-type ATPase; ATPase, P-type (transporting), HAD superfamily, subfamily IC YP_004410983.1 COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR013027; KEGG: amt:Amet_0679 oxidoreductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PRIAM: Glutamate synthase (NADPH); SPTR: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; IMG reference gene:2503956646; PFAM: Pyridine nucleotide-disulphide oxidoreductase YP_004410984.1 COGs: COG0622 phosphoesterase; InterPro IPR004843:IPR000979; KEGG: csh:Closa_0691 phosphodiesterase, MJ0936 family; PFAM: Metallo-dependent phosphatase; SPTR: uncharacterized protein; TIGRFAM: Phosphodiesterase MJ0936; IMG reference gene:2503956647; PFAM: Calcineurin-like phosphoesterase; TIGRFAM: phosphoesterase, MJ0936 family YP_004410985.1 KEGG: sta:STHERM_c01800 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956648 YP_004410986.1 COGs: COG0334 Glutamate dehydrogenase/leucine dehydrogenase; InterPro IPR006097:IPR006096; KEGG: aba:Acid345_0942 glutamate dehydrogenase; PFAM: Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain; PRIAM: Glutamate dehydrogenase (NADP(+)); SMART: Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; SPTR: Glutamate dehydrogenase (NADP); IMG reference gene:2503956649; PFAM: Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Glu/Leu/Phe/Val dehydrogenase, dimerisation domain YP_004410987.1 COGs: COG2270 Permease of the major facilitator superfamily; InterPro IPR011701; KEGG: sfu:Sfum_3450 major facilitator transporter; PFAM: Major facilitator superfamily MFS-1; SPTR: Major facilitator superfamily MFS_1; IMG reference gene:2503956650; PFAM: Vacuole effluxer Atg22 like YP_004410988.1 KEGG: cti:RALTA_B1578 NAD+-dependent betaine aldehyde dehydrogenase; SPTR: NAD+-dependent betaine aldehyde dehydrogenase; IMG reference gene:2503956652 YP_004410989.1 COGs: COG0812 UDP-N-acetylmuramate dehydrogenase; HAMAP: UDP-N-acetylenolpyruvoylglucosamine reductase; InterPro IPR003170:IPR006094:IPR011601; KEGG: dap:Dacet_0478 UDP-N-acetylenolpyruvoylglucosamine reductase; PFAM: UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal; FAD linked oxidase, N-terminal; PRIAM: UDP-N-acetylmuramate dehydrogenase; SPTR: UDP-N-acetylenolpyruvoylglucosamine reductase; TIGRFAM: UDP-N-acetylenolpyruvoylglucosamine reductase; IMG reference gene:2503956653; PFAM: FAD binding domain; UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; TIGRFAM: UDP-N-acetylenolpyruvoylglucosamine reductase YP_004410990.1 COGs: COG0215 Cysteinyl-tRNA synthetase; InterPro IPR015803; KEGG: sta:STHERM_c18260 hypothetical protein; PFAM: Cysteinyl-tRNA synthetase, class Ia; PRIAM: Cysteine--tRNA ligase; SPTR: uncharacterized protein; TIGRFAM: Cysteinyl-tRNA synthetase, class Ia; IMG reference gene:2503956654; PFAM: tRNA synthetases class I (C) catalytic domain; TIGRFAM: cysteinyl-tRNA synthetase YP_004410991.1 COGs: COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog; InterPro IPR007627:IPR013249:IPR014284; KEGG: ssm:Spirs_2153 RNA polymerase, sigma-24 subunit, ECF subfamily; PFAM: RNA polymerase sigma factor 70, region 4 type 2; RNA polymerase sigma-70 region 2; SPTR: RNA polymerase sigma-24 factor, ; TIGRFAM: RNA polymerase sigma-70; IMG reference gene:2503956655; PFAM: Sigma-70, region 4; Sigma-70 region 2; TIGRFAM: RNA polymerase sigma factor, sigma-70 family YP_004410992.1 KEGG: ssm:Spirs_2152 transmembrane anti-sigma factor; SPTR: uncharacterized protein; IMG reference gene:2503956656 YP_004410993.1 COGs: COG0395 ABC-type sugar transport system permease component; InterPro IPR000515; KEGG: pjd:Pjdr2_0473 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Binding-protein-dependent transport systems inner membrane component; IMG reference gene:2503956657; PFAM: Binding-protein-dependent transport system inner membrane component YP_004410994.1 COGs: COG4209 ABC-type polysaccharide transport system permease component; InterPro IPR000515; KEGG: pjd:Pjdr2_0472 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Binding-protein-dependent transport systems inner membrane component; IMG reference gene:2503956658; PFAM: Binding-protein-dependent transport system inner membrane component YP_004410995.1 InterPro IPR001286; KEGG: amd:AMED_3993 hypothetical protein; PFAM: Glycoside hydrolase, family 59; PRIAM: Galactosylceramidase; SPTR: uncharacterized protein; IMG reference gene:2503956659; PFAM: Glycosyl hydrolase 59 YP_004410996.1 COGs: COG1653 ABC-type sugar transport system periplasmic component; InterPro IPR006059; KEGG: pjd:Pjdr2_0474 extracellular solute-binding protein family 1; PFAM: Bacterial extracellular solute-binding, family 1; SPTR: Extracellular solute-binding protein family 1; IMG reference gene:2503956660; PFAM: Domain of unknown function (DUF3502); Bacterial extracellular solute-binding protein YP_004410997.1 COGs: COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain; InterPro IPR000005:IPR018060; KEGG: ppy:PPE_03254 AraC-type DNA-binding domain-containing protein; PFAM: HTH transcriptional regulator, AraC; SMART: Helix-turn-helix, AraC type, DNA binding domain; SPTR: AraC-type DNA-binding domain-containing protein; IMG reference gene:2503956661; PFAM: Bacterial regulatory helix-turn-helix proteins, AraC family YP_004410998.1 COGs: COG0525 Valyl-tRNA synthetase; HAMAP: Valyl-tRNA synthetase; InterPro IPR002303:IPR002300:IPR013155:IPR019499; KEGG: ssm:Spirs_2147 valyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class Ia; Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding; Valyl-tRNA synthetase, class Ia, tRNA-binding arm; PRIAM: Valine--tRNA ligase; SPTR: Valyl-tRNA synthetase; TIGRFAM: Valyl-tRNA synthetase; IMG reference gene:2503956662; PFAM: tRNA synthetases class I (I, L, M and V); Anticodon-binding domain; Valyl tRNA synthetase tRNA binding arm; TIGRFAM: valyl-tRNA synthetase YP_004410999.1 KEGG: pnu:Pnuc_1747 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956663 YP_004411000.1 COGs: COG0826 Collagenase and related protease; InterPro IPR001539; KEGG: sta:STHERM_c16410 hypothetical protein; PFAM: Peptidase U32; SPTR: uncharacterized protein; IMG reference gene:2503956664; PFAM: Peptidase U32 YP_004411001.1 COGs: COG0466 ATP-dependent Lon protease; InterProIPR003111:IPR003959:IPR008269:IPR004815:IPR 003593; KEGG: ssm:Spirs_2144 ATP-dependent protease La; PFAM: Peptidase S16, Lon C-terminal; ATPase, AAA-type, core; Peptidase S16, lon N-terminal; PRIAM: Endopeptidase La; SMART: Peptidase S16, lon N-terminal; ATPase, AAA+ type, core; SPTR: ATP-dependent protease La; TIGRFAM: Peptidase S16, ATP-dependent protease La; IMG reference gene:2503956665; PFAM: ATP-dependent protease La (LON) domain; ATPase associated with various cellular activities (AAA); Lon protease (S16) C-terminal proteolytic domain; TIGRFAM: ATP-dependent protease La YP_004411002.1 COGs: COG1738 conserved hypothetical protein; InterPro IPR003744; KEGG: mma:MM_1800 transporter; PFAM: Protein of unknown function DUF165; SPTR: Transporter; TIGRFAM: Protein of unknown function DUF165; IMG reference gene:2503956666; PFAM: Uncharacterized ACR, YhhQ family COG1738; TIGRFAM: conserved hypothetical integral membrane protein YP_004411003.1 InterPro IPR010828; KEGG: amt:Amet_1520 hypothetical protein; PFAM: Alcohol acetyltransferase; SPTR: uncharacterized protein; IMG reference gene:2503956667; PFAM: Alcohol acetyltransferase YP_004411004.1 COGs: COG0642 Signal transduction histidine kinase; InterPro IPR003661:IPR003594; KEGG: amt:Amet_1519 integral membrane sensor signal transduction histidine kinase; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; SMART: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; SPTR: Integral membrane sensor signal transduction histidine kinase; IMG reference gene:2503956668; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain YP_004411005.1 COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789:IPR001867; KEGG: amt:Amet_1518 two component transcriptional regulator; PFAM: Signal transduction response regulator, receiver domain; Signal transduction response regulator, C-terminal; SMART: Signal transduction response regulator, receiver domain; Signal transduction response regulator, C-terminal; SPTR: Two component transcriptional regulator, winged helix family; IMG reference gene:2503956669; PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal YP_004411006.1 KEGG: mxa:MXAN_4735 hypothetical protein; SPTR: membrane protein; manually curated; IMG reference gene:2503956670 YP_004411007.1 COGs: COG1381 Recombinational DNA repair protein (RecF pathway); InterPro IPR003717; KEGG: ssm:Spirs_2143 DNA repair protein RecO; PFAM: Recombination protein O, RecO; SPTR: uncharacterized protein; TIGRFAM: Recombination protein O, RecO; IMG reference gene:2503956671; PFAM: Recombination protein O C terminal; Recombination protein O N terminal; TIGRFAM: DNA repair protein RecO YP_004411008.1 COGs: COG0608 Single-stranded DNA-specific exonuclease; InterPro IPR001667:IPR003156:IPR004610; KEGG: ssm:Spirs_2141 single-stranded-DNA-specific exonuclease RecJ; PFAM: Phosphoesterase, RecJ-like; Phosphoesterase, DHHA1; SPTR: Single-stranded-DNA-specific exonuclease; TIGRFAM: Bacterial RecJ exonuclease; IMG reference gene:2503956672; PFAM: DHH family; DHHA1 domain; TIGRFAM: single-stranded-DNA-specific exonuclease RecJ YP_004411009.1 HAMAP: Ribosomal protein S21; InterPro IPR001911; KEGG: ssm:Spirs_2139 ribosomal protein S21; PFAM: Ribosomal protein S21; SPTR: 30S ribosomal protein S21; TIGRFAM: Ribosomal protein S21; IMG reference gene:2503956673; PFAM: Ribosomal protein S21; TIGRFAM: ribosomal protein S21 YP_004411010.1 InterPro IPR015067; KEGG: amt:Amet_1218 hypothetical protein; PFAM: Protein of unknown function DUF1893; SPTR: uncharacterized protein; IMG reference gene:2503956674; PFAM: Domain of unknown function (DUF1893) YP_004411011.1 COGs: COG1641 conserved hypothetical protein; InterPro IPR002822; KEGG: mpi:Mpet_1113 hypothetical protein; PFAM: Uncharacterised protein family UPF0272; SPTR: UPF0272 protein CUS_2000; IMG reference gene:2503956675; PFAM: Protein of unknown function DUF111 YP_004411012.1 COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006139:IPR006140; KEGG: ssm:Spirs_2138 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; PRIAM: Phosphoglycerate dehydrogenase; SPTR: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; IMG reference gene:2503956676; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain YP_004411013.1 COGs: COG1932 Phosphoserine aminotransferase; HAMAP: Phosphoserine aminotransferase; InterPro IPR022278:IPR000192; KEGG: ssm:Spirs_2137 phosphoserine aminotransferase; PFAM: Aminotransferase, class V/Cysteine desulfurase; PRIAM: Phosphoserine transaminase; SPTR: Phosphoserine aminotransferase; IMG reference gene:2503956677; PFAM: Aminotransferase class-V; TIGRFAM: phosphoserine aminotransferase YP_004411014.1 COGs: COG1522 Transcriptional regulators; InterPro IPR019888; KEGG: ssm:Spirs_2136 transcriptional regulator, AsnC family; SMART: Transcription regulator AsnC-type; SPTR: HTH-type transcriptional regulator; IMG reference gene:2503956678 YP_004411015.1 KEGG: ssm:Spirs_2368 acyltransferase; SPTR: Phospholipid/glycerol acyltransferase; IMG reference gene:2503956679; PFAM: Acyltransferase YP_004411016.1 COGs: COG0323 DNA mismatch repair enzyme (predicted ATPase); HAMAP: DNA mismatch repair protein, MutL; InterProIPR020667:IPR003594:IPR013507:IPR014790:IPR 014763; KEGG: ssm:Spirs_2361 DNA mismatch repair protein MutL; PFAM: MutL, C-terminal, dimerisation; DNA mismatch repair protein, C-terminal; ATPase-like, ATP-binding domain; SMART: MutL, C-terminal, dimerisation; SPTR: DNA mismatch repair protein MutL; TIGRFAM: DNA mismatch repair protein, N-terminal; IMG reference gene:2503956680; PFAM: MutL C terminal dimerisation domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; DNA mismatch repair protein, C-terminal domain; TIGRFAM: DNA mismatch repair protein MutL YP_004411017.1 KEGG: nve:NEMVE_v1g200105 hypothetical protein; SPTR: Predicted protein; IMG reference gene:2503956681 YP_004411018.1 KEGG: ssm:Spirs_2359 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956682 YP_004411019.1 COGs: COG1078 HD superfamily phosphohydrolase; InterPro IPR003607; KEGG: ssm:Spirs_2352 metal dependent phosphohydrolase; SMART: Metal-dependent phosphohydrolase, HD domain; SPTR: uncharacterized protein; IMG reference gene:2503956683; PFAM: HD domain YP_004411020.1 KEGG: pyo:PY02442 hypothetical protein; SPTR: Zinc finger, C2H2 type, ; IMG reference gene:2503956685 YP_004411021.1 COGs: COG2896 Molybdenum cofactor biosynthesis protein; InterPro IPR007197:IPR006638; KEGG: ate:Athe_0829 molybdenum cofactor biosynthesis protein A; PFAM: Radical SAM; SMART: Elongator protein 3/MiaB/NifB; SPTR: Molybdenum cofactor biosynthesis protein A; IMG reference gene:2503956686; PFAM: Radical SAM superfamily YP_004411022.1 COGs: COG2896 Molybdenum cofactor biosynthesis protein; InterPro IPR007197:IPR006638; KEGG: pab:PAB2273 molybdenum cofactor biosynthesis protein A; PFAM: Radical SAM; SMART: Elongator protein 3/MiaB/NifB; SPTR: Radical SAM domain protein; manually curated; IMG reference gene:2503956687; PFAM: Radical SAM superfamily YP_004411023.1 KEGG: dda:Dd703_0966 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956688 YP_004411024.1 KEGG: dvi:Dvir_GJ17340 GJ17340 gene product from transcript GJ17340-RA; SPTR: GJ17340; IMG reference gene:2503956689 YP_004411025.1 InterPro IPR013217; KEGG: npu:Npun_R0686 methyltransferase type 12; PFAM: Methyltransferase type 12; SPTR: Methyltransferase domain family; IMG reference gene:2503956690 YP_004411026.1 InterPro IPR011701; KEGG: cbk:CLL_A2467 permease of the major facilitator superfamily; PFAM: Major facilitator superfamily MFS-1; SPTR: Possible MDR-type permease; IMG reference gene:2503956691; PFAM: Major Facilitator Superfamily YP_004411027.1 KEGG: pyo:PY05620 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956692 YP_004411028.1 KEGG: amr:AM1_1921 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956693 YP_004411029.1 InterPro IPR003675; KEGG: llk:LLKF_0092 CAAX amino terminal protease; PFAM: Abortive infection protein; SPTR: CAAX amino terminal protease; IMG reference gene:2503956694; PFAM: CAAX amino terminal protease YP_004411030.1 COGs: COG0535 Fe-S oxidoreductase; InterPro IPR007197; KEGG: vdi:Vdis_1894 radical SAM domain-containing protein; PFAM: Radical SAM; SPTR: heme biosynthesis protein; IMG reference gene:2503956695; PFAM: Radical SAM superfamily; TIGRFAM: radical SAM additional 4Fe4S-binding domain YP_004411031.1 COGs: COG0525 Valyl-tRNA synthetase; HAMAP: Valyl-tRNA synthetase; InterPro IPR002303:IPR002300:IPR013155:IPR019499; KEGG: ssm:Spirs_2147 valyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class Ia; Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding; Valyl-tRNA synthetase, class Ia, tRNA-binding arm; PRIAM: Valine--tRNA ligase; SPTR: Valyl-tRNA synthetase; TIGRFAM: Valyl-tRNA synthetase; IMG reference gene:2503956696; PFAM: tRNA synthetases class I (I, L, M and V); Anticodon-binding domain; Valyl tRNA synthetase tRNA binding arm; TIGRFAM: valyl-tRNA synthetase YP_004411032.1 COGs: COG5002 Signal transduction histidine kinase; InterPro IPR003660:IPR013767:IPR003661:IPR003594; KEGG: dol:Dole_1931 PAS/PAC sensor signal transduction histidine kinase; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; HAMP linker domain; PAS fold; SMART: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; HAMP linker domain; SPTR: Multi-sensor signal transduction histidine kinase; IMG reference gene:2503956697; PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; TIGRFAM: PAS domain S-box YP_004411033.1 COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789:IPR001867; KEGG: sta:STHERM_c05370 transcriptional regulatory protein; PFAM: Signal transduction response regulator, receiver domain; Signal transduction response regulator, C-terminal; SMART: Signal transduction response regulator, receiver domain; Signal transduction response regulator, C-terminal; SPTR: Transcriptional regulatory protein; IMG reference gene:2503956698; PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal YP_004411034.1 COGs: COG0588 Phosphoglycerate mutase 1; HAMAP: Phosphoglycerate mutase 1; InterPro IPR005952:IPR013078; KEGG: sus:Acid_4374 phosphoglycerate mutase; PFAM: Histidine phosphatase superfamily, clade-1; PRIAM: Bisphosphoglycerate mutase; SMART: Histidine phosphatase superfamily, clade-1; SPTR: 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; TIGRFAM: Phosphoglycerate mutase 1; IMG reference gene:2503956700; PFAM: Phosphoglycerate mutase; TIGRFAM: phosphoglycerate mutase, BPG-dependent, family 1 YP_004411035.1 COGs: COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase; InterPro IPR000595:IPR001808; KEGG: cth:Cthe_2775 Crp/FNR family transcriptional regulator; PFAM: Cyclic nucleotide-binding domain; HTH transcriptional regulator, Crp; SMART: Cyclic nucleotide-binding domain; HTH transcriptional regulator, Crp; SPTR: Transcriptional regulator, Crp/Fnr family; IMG reference gene:2503956701; PFAM: Bacterial regulatory proteins, crp family; Cyclic nucleotide-binding domain YP_004411036.1 COGs: COG3808 Inorganic pyrophosphatase; InterPro IPR004131; KEGG: cth:Cthe_1425 membrane-bound proton-translocating pyrophosphatase; PFAM: Pyrophosphate-energised proton pump; PRIAM: Inorganic diphosphatase; SPTR: Inorganic diphosphatase; IMG reference gene:2503956702; PFAM: Inorganic H+ pyrophosphatase; TIGRFAM: vacuolar-type H(+)-translocating pyrophosphatase YP_004411037.1 KEGG: pmg:P9301_08931 urease subunit alpha; SPTR: uncharacterized protein; IMG reference gene:2503956703 YP_004411038.1 HAMAP: Ribosomal protein L28; InterPro IPR001383; KEGG: ssm:Spirs_2771 ribosomal protein L28; PFAM: Ribosomal protein L28; SPTR: 50S ribosomal protein L28; TIGRFAM: Ribosomal protein L28; IMG reference gene:2503956704; PFAM: Ribosomal L28 family; TIGRFAM: ribosomal protein L28 YP_004411039.1 COGs: COG0460 Homoserine dehydrogenase; InterPro IPR001048:IPR002912:IPR005106:IPR001342; KEGG: ssm:Spirs_2770 aspartate kinase; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; PRIAM: Aspartate kinase., Homoserine dehydrogenase; SPTR: Bifunctional aspartokinase/homoserine dehydrogenase II; IMG reference gene:2503956705; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain; Amino acid kinase; TIGRFAM: aspartate kinase YP_004411040.1 COGs: COG0498 Threonine synthase; InterPro IPR001926:IPR004450; KEGG: fph:Fphi_0311 threonine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; PRIAM: Threonine synthase; SPTR: Threonine synthase; TIGRFAM: Threonine synthase; IMG reference gene:2503956706; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase YP_004411041.1 COGs: COG0153 Galactokinase; InterPro IPR019539:IPR006204; KEGG: ssm:Spirs_2254 galactokinase; PFAM: Galactokinase galactose-binding domain; GHMP kinase; PRIAM: Galactokinase; SPTR: uncharacterized protein; IMG reference gene:2503956707; PFAM: Galactokinase galactose-binding signature; GHMP kinases N terminal domain YP_004411042.1 COGs: COG0514 Superfamily II DNA helicase; InterPro IPR011545:IPR001650:IPR004589:IPR014001; KEGG: ssm:Spirs_2762 ATP-dependent DNA helicase, RecQ family; PFAM: Helicase, C-terminal; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; SMART: DEAD-like helicase, N-terminal; Helicase, C-terminal; SPTR: ATP-dependent DNA helicase, RecQ family; TIGRFAM: DNA helicase, ATP-dependent, RecQ type; manually curated; IMG reference gene:2503956708; PFAM: Helicase conserved C-terminal domain; DEAD/DEAH box helicase; TIGRFAM: ATP-dependent DNA helicase, RecQ family YP_004411043.1 COGs: COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase; InterPro IPR002123; KEGG: mxa:MXAN_3330 1-acyl-sn-glycerol-3-phosphate acyltransferase; PFAM: Phospholipid/glycerol acyltransferase; SMART: Phospholipid/glycerol acyltransferase; SPTR: uncharacterized protein; IMG reference gene:2503956709; PFAM: Acyltransferase; TIGRFAM: 1-acyl-sn-glycerol-3-phosphate acyltransferases YP_004411044.1 InterPro IPR013378; KEGG: geo:Geob_1283 outer membrane adhesin like proteiin; PFAM: Listeria/Bacterioides repeat; SPTR: Outer membrane adhesin like proteiin; TIGRFAM: Listeria/Bacterioides repeat; IMG reference gene:2503956710; PFAM: Listeria-Bacteroides repeat domain (List_Bact_rpt); TIGRFAM: Listeria/Bacterioides repeat YP_004411045.1 COGs: COG0226 ABC-type phosphate transport system periplasmic component; InterPro IPR011862; KEGG: ssm:Spirs_1702 phosphate binding protein; SPTR: Phosphate binding protein; TIGRFAM: Phosphate binding protein; IMG reference gene:2503956711; TIGRFAM: phosphate binding protein YP_004411046.1 COGs: COG0573 ABC-type phosphate transport system permease component; InterPro IPR000515:IPR011864; KEGG: ssm:Spirs_1701 phosphate ABC transporter, inner membrane subunit PstC; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Phosphate ABC transporter, inner membrane subunit PstC; TIGRFAM: Phosphate ABC transporter, permease PstC; IMG reference gene:2503956712; PFAM: Binding-protein-dependent transport system inner membrane component; TIGRFAM: phosphate ABC transporter, permease PstC; phosphate ABC transporter, permease PstA YP_004411047.1 COGs: COG0581 ABC-type phosphate transport system permease component; InterPro IPR000515:IPR005672; KEGG: ssm:Spirs_1700 phosphate ABC transporter, inner membrane subunit PstA; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Phosphate ABC transporter, inner membrane subunit PstA; TIGRFAM: Phosphate transport system permease 2; IMG reference gene:2503956713; PFAM: Binding-protein-dependent transport system inner membrane component; TIGRFAM: phosphate ABC transporter, permease PstA YP_004411048.1 COGs: COG1117 ABC-type phosphate transport system ATPase component; InterPro IPR003439:IPR005670:IPR003593; KEGG: cbf:CLI_2585 phosphate transporter ATP-binding protein; PFAM: ABC transporter-like; PRIAM: Phosphate-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: Phosphate ABC transporter, ATP-binding protein; TIGRFAM: Phosphate transport system permease 1; IMG reference gene:2503956714; PFAM: ABC transporter; TIGRFAM: phosphate ABC transporter, ATP-binding protein YP_004411049.1 COGs: COG0704 Phosphate uptake regulator; InterPro IPR008170; KEGG: sta:STHERM_c05380 transcriptional regulatory protein; PFAM: PhoU; SPTR: Transcriptional regulatory protein; IMG reference gene:2503956715; PFAM: PhoU domain; TIGRFAM: phosphate transport system regulatory protein PhoU YP_004411050.1 InterPro IPR013216; KEGG: cbt:CLH_2444 methyltransferase; PFAM: Methyltransferase type 11; SPTR: Methyltransferase; IMG reference gene:2503956716; PFAM: Methyltransferase domain YP_004411051.1 COGs: COG0156 7-keto-8-aminopelargonate synthetase; InterPro IPR004839; KEGG: ssm:Spirs_2756 8-amino-7-oxononanoate synthase; PFAM: Aminotransferase, class I/classII; PRIAM: Glycine C-acetyltransferase; SPTR: 8-amino-7-oxononanoate synthase; IMG reference gene:2503956717; PFAM: Aminotransferase class I and II; TIGRFAM: 8-amino-7-oxononanoate synthase YP_004411052.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR000408; KEGG: aeh:Mlg_2687 regulator of chromosome condensation, RCC1; PFAM: Regulator of chromosome condensation, RCC1; SPTR: uncharacterized protein; IMG reference gene:2503956718; PFAM: Regulator of chromosome condensation (RCC1) repeat YP_004411053.1 COGs: COG1640 4-alpha-glucanotransferase; InterPro IPR003385; KEGG: ssm:Spirs_4115 4-alpha-glucanotransferase; PFAM: Glycoside hydrolase, family 77; PRIAM: 4-alpha-glucanotransferase; SPTR: 4-alpha-glucanotransferase; TIGRFAM: Glycoside hydrolase, family 77; IMG reference gene:2503956719; PFAM: 4-alpha-glucanotransferase; TIGRFAM: 4-alpha-glucanotransferase YP_004411054.1 COGs: COG1609 Transcriptional regulators; InterPro IPR001761:IPR000843; KEGG: ssm:Spirs_0925 transcriptional regulator, LacI family; PFAM: Periplasmic binding protein/LacI transcriptional regulator; SMART: HTH transcriptional regulator, LacI; SPTR: Alanine racemase; IMG reference gene:2503956720; PFAM: Bacterial regulatory proteins, lacI family; family YP_004411055.1 COGs: COG0395 ABC-type sugar transport system permease component; InterPro IPR000515; KEGG: ccb:Clocel_0515 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Binding-protein-dependent transport systems inner membrane component; IMG reference gene:2503956721; PFAM: Binding-protein-dependent transport system inner membrane component YP_004411056.1 COGs: COG1175 ABC-type sugar transport systems permease components; InterPro IPR000515; KEGG: ccb:Clocel_0514 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Binding-protein-dependent transport systems inner membrane component; IMG reference gene:2503956722; PFAM: Binding-protein-dependent transport system inner membrane component YP_004411057.1 COGs: COG1653 ABC-type sugar transport system periplasmic component; InterPro IPR006059; KEGG: ccb:Clocel_0513 extracellular solute-binding protein family 1; PFAM: Bacterial extracellular solute-binding, family 1; SPTR: Extracellular solute-binding protein family 1; IMG reference gene:2503956723; PFAM: Bacterial extracellular solute-binding protein YP_004411058.1 COGs: COG0516 IMP dehydrogenase/GMP reductase; InterPro IPR001093:IPR000644; KEGG: afn:Acfer_1275 IMP dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; Cystathionine beta-synthase, core; PRIAM: IMP dehydrogenase; SPTR: uncharacterized protein; IMG reference gene:2503956724; PFAM: CBS domain; IMP dehydrogenase / GMP reductase domain; TIGRFAM: inosine-5'-monophosphate dehydrogenase YP_004411059.1 COGs: COG0325 enzyme with a TIM-barrel fold; InterPro IPR001608:IPR011078; KEGG: ssm:Spirs_2472 alanine racemase domain protein; PFAM: Alanine racemase, N-terminal; SPTR: uncharacterized protein; TIGRFAM: pyridoxal phosphate-dependent enzyme, YBL036C type; IMG reference gene:2503956726; PFAM: Alanine racemase, N-terminal domain; TIGRFAM: pyridoxal phosphate enzyme, YggS family YP_004411060.1 KEGG: ssm:Spirs_2471 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956727 YP_004411061.1 COGs: COG0564 Pseudouridylate synthase 23S RNA-specific; InterPro IPR006145:IPR006225; KEGG: tpd:Teth39_1349 RluA family pseudouridine synthase; PFAM: Pseudouridine synthase, RsuA and RluB/C/D/E/F; SPTR: Pseudouridine synthase; TIGRFAM: Pseudouridine synthase, RluC/RluD; IMG reference gene:2503956728; PFAM: RNA pseudouridylate synthase; TIGRFAM: pseudouridine synthase, RluA family YP_004411062.1 COGs: COG0491 Zn-dependent hydrolase including glyoxylase; InterPro IPR001279; KEGG: ssm:Spirs_2469 hypothetical protein; PFAM: Beta-lactamase-like; SMART: Beta-lactamase-like; SPTR: Predicted beta lactamase like protein; IMG reference gene:2503956729; PFAM: Metallo-beta-lactamase superfamily YP_004411063.1 InterPro IPR001646; KEGG: ssm:Spirs_2468 pentapeptide repeat protein; PFAM: Pentapeptide repeat; SPTR: Predicted pentapeptide protein; IMG reference gene:2503956730 YP_004411064.1 COGs: COG1162 GTPase; HAMAP: Ribosome biogenesis GTPase RsgA, InterPro IPR004881; KEGG: sta:STHERM_c17030 GTPase YjeQ; PFAM: Ribosome biogenesis GTPase RsgA, SPTR: GTPase YjeQ; TIGRFAM: Ribosome biogenesis GTPase RsgA, IMG reference gene:2503956731; PFAM: Protein of unknown function, DUF258; TIGRFAM: ribosome small subunit-dependent GTPase A YP_004411065.1 COGs: COG1193 Mismatch repair ATPase (MutS family); InterPro IPR000432:IPR002625:IPR007696; KEGG: ssm:Spirs_2465 MutS2 family protein; PFAM: DNA mismatch repair protein MutS, C-terminal; Smr protein/MutS2 C-terminal; SMART: DNA mismatch repair protein MutS, C-terminal; DNA mismatch repair protein MutS, core; Smr protein/MutS2 C-terminal; SPTR: MutS2 protein; IMG reference gene:2503956732; PFAM: MutS domain V; Smr domain; TIGRFAM: MutS2 family protein YP_004411066.1 COGs: COG3819 membrane protein; InterPro IPR010374; KEGG: cpe:CPE1427 hypothetical protein; PFAM: Protein of unknown function DUF969; SPTR: uncharacterized protein; IMG reference gene:2503956733; PFAM: Protein of unknown function (DUF969) YP_004411067.1 COGs: COG3817 membrane protein; InterPro IPR009323; KEGG: cbt:CLH_1447 permease; PFAM: Protein of unknown function DUF979; SPTR: Permease; IMG reference gene:2503956734; PFAM: Protein of unknown function (DUF979) YP_004411068.1 COGs: COG2039 Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase); HAMAP: Peptidase C15, pyroglutamyl peptidase I; InterPro IPR000816; KEGG: cpe:CPE1425 pyrrolidone-carboxylate peptidase; PFAM: Peptidase C15, pyroglutamyl peptidase I; PRIAM: Pyroglutamyl-peptidase I; SPTR: Pyrrolidone-carboxylate peptidase; TIGRFAM: Peptidase C15, pyroglutamyl peptidase I; IMG reference gene:2503956735; PFAM: Pyroglutamyl peptidase; TIGRFAM: pyroglutamyl-peptidase I YP_004411069.1 InterPro IPR009288; KEGG: cpe:CPE1424 hypothetical protein; PFAM: AIG2-like; SPTR: uncharacterized protein CPE1424; IMG reference gene:2503956736; PFAM: AIG2-like family YP_004411070.1 COGs: COG2820 Uridine phosphorylase; InterPro IPR000845:IPR010058; KEGG: spa:M6_Spy1599 uridine phosphorylase; PFAM: Nucleoside phosphorylase domain; PRIAM: Uridine phosphorylase; SPTR: uncharacterized protein; TIGRFAM: Uridine phosphorylase; IMG reference gene:2503956737; PFAM: Phosphorylase superfamily; TIGRFAM: uridine phosphorylase YP_004411071.1 KEGG: nvi:100118784 similar to ENSANGP00000010411; SPTR: Two-component system sensor histidine kinase/response regulator hybrid; IMG reference gene:2503956738 YP_004411072.1 KEGG: clo:HMPREF0868_0782 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956739 YP_004411073.1 COGs: COG0716 Flavodoxins; InterPro IPR008254:IPR010087; KEGG: emi:Emin_0878 flavodoxin; PFAM: Flavodoxin/nitric oxide synthase; SPTR: uncharacterized protein; TIGRFAM: Flavodoxin, short chain; IMG reference gene:2503956740; PFAM: Flavodoxin; TIGRFAM: flavodoxin, short chain YP_004411074.1 COGs: COG0821 Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis; HAMAP: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type; InterPro IPR004588; KEGG: sta:STHERM_c12020 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; PFAM: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type; SPTR: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; TIGRFAM: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type; IMG reference gene:2503956741; PFAM: GcpE protein; TIGRFAM: 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase YP_004411075.1 COGs: COG0178 Excinuclease ATPase subunit; HAMAP: Excinuclease ABC, A subunit; InterPro IPR004602:IPR003439; KEGG: ssm:Spirs_2452 excinuclease ABC, A subunit; PFAM: ABC transporter-like; SPTR: Excinuclease ABC, subunit A; TIGRFAM: Excinuclease ABC, A subunit; IMG reference gene:2503956742; PFAM: ABC transporter; TIGRFAM: excinuclease ABC, A subunit YP_004411076.1 KEGG: ssm:Spirs_2451 organic solvent tolerance protein OstA; SPTR: uncharacterized protein; IMG reference gene:2503956743 YP_004411077.1 COGs: COG1702 Phosphate starvation-inducible protein PhoH predicted ATPase; InterPro IPR003714; KEGG: ssm:Spirs_2450 PhoH family protein; PFAM: PhoH-like protein; SPTR: PhoH-like protein; IMG reference gene:2503956744; PFAM: PhoH-like protein YP_004411078.1 COGs: COG1480 membrane-associated HD superfamily hydrolase; InterPro IPR006674:IPR006675:IPR003607; KEGG: ssm:Spirs_2449 7TM receptor with intracellular metal dependent phosphohydrolase; PFAM: Metal-dependent phosphohydrolase, HD subdomain; SMART: Metal-dependent phosphohydrolase, HD domain; SPTR: HD domain protein; TIGRFAM: Uncharacterised protein family HDIG; IMG reference gene:2503956745; PFAM: 7TM-HD extracellular; HD domain; 7TM receptor with intracellular HD hydrolase; TIGRFAM: uncharacterized domain HDIG YP_004411079.1 COGs: COG0319 metal-dependent hydrolase; HAMAP: Uncharacterised protein family UPF0054, metalloprotease YbeY, predicted; InterPro IPR002036; KEGG: tde:TDE1242 metalloprotease; PFAM: Uncharacterised protein family UPF0054, metalloprotease YbeY, predicted; SPTR: metalloprotease TDE_1242; TIGRFAM: Uncharacterised protein family UPF0054, metalloprotease YbeY, predicted; IMG reference gene:2503956746; PFAM: Uncharacterized protein family UPF0054; TIGRFAM: metalloprotein, YbeY/UPF0054 family YP_004411080.1 COGs: COG1253 Hemolysins and related protein containing CBS domains; InterPro IPR000644:IPR005170; KEGG: ssm:Spirs_2447 transporter-associated region; PFAM: Cystathionine beta-synthase, core; Transporter-associated domain; SPTR: Hemolysin C; IMG reference gene:2503956747; PFAM: CBS domain; Transporter associated domain YP_004411081.1 COGs: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; InterPro IPR020828:IPR020829:IPR006424; KEGG: bhr:BH0057 glyceraldehyde 3-phosphate dehydrogenase; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; PRIAM: Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating); SMART: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; SPTR: Glyceraldehyde 3-phosphate dehydrogenase; TIGRFAM: Glyceraldehyde-3-phosphate dehydrogenase, type I; IMG reference gene:2503956748; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I YP_004411082.1 COGs: COG0126 3-phosphoglycerate kinase; HAMAP: Phosphoglycerate kinase; InterPro IPR001576; KEGG: ssm:Spirs_2444 phosphoglycerate kinase; PFAM: Phosphoglycerate kinase; PRIAM: Phosphoglycerate kinase; SPTR: Phosphoglycerate kinase; IMG reference gene:2503956749; PFAM: Phosphoglycerate kinase YP_004411083.1 COGs: COG0149 Triosephosphate isomerase; InterPro IPR000652; KEGG: sta:STHERM_c09810 triosephosphate isomerase; PFAM: Triosephosphate isomerase; PRIAM: Triose-phosphate isomerase; SPTR: Triosephosphate isomerase; TIGRFAM: Triosephosphate isomerase; IMG reference gene:2503956750; PFAM: Triosephosphate isomerase; TIGRFAM: triosephosphate isomerase YP_004411084.1 InterPro IPR004692; KEGG: tde:TDE1238 preprotein translocase subunit SecG; PFAM: Preprotein translocase SecG subunit; SPTR: Preprotein translocase subunit SecG; TIGRFAM: Preprotein translocase SecG subunit; IMG reference gene:2503956751; PFAM: Preprotein translocase SecG subunit; TIGRFAM: protein translocase, SecG subunit YP_004411085.1 KEGG: bfo:BRAFLDRAFT_98883 hypothetical protein; manually curated; IMG reference gene:2503956752 YP_004411086.1 KEGG: ssm:Spirs_2441 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956753 YP_004411087.1 InterPro IPR015391:IPR000297; KEGG: ssm:Spirs_2440 PpiC-type peptidyl-prolyl cis-trans isomerase; PFAM: Peptidyl-prolyl cis-trans isomerase, PpiC-type; SurA N-terminal; SPTR: Basic membrane protein; IMG reference gene:2503956754; PFAM: SurA N-terminal domain; PPIC-type PPIASE domain YP_004411088.1 COGs: COG0781 Transcription termination factor; InterPro IPR006027; KEGG: tde:TDE1657 transcription antitermination protein NusB; PFAM: NusB/RsmB/TIM44; SPTR: N utilization substance protein B homolog; IMG reference gene:2503956755; PFAM: NusB family; TIGRFAM: transcription antitermination factor NusB YP_004411089.1 COGs: COG0024 Methionine aminopeptidase; InterPro IPR000994:IPR002467; KEGG: ssm:Spirs_2437 methionine aminopeptidase, type I; PFAM: Peptidase M24, structural domain; PRIAM: Methionyl aminopeptidase; SPTR: Methionine aminopeptidase; TIGRFAM: Peptidase M24A, methionine aminopeptidase, subfamily 1; IMG reference gene:2503956756; PFAM: Metallopeptidase M24; TIGRFAM: methionine aminopeptidase, type I YP_004411090.1 COGs: COG2236 phosphoribosyltransferase; KEGG: ssm:Spirs_2435 phosphoribosyl transferase domain protein; SPTR: Phosphoribosyl transferase domain protein; IMG reference gene:2503956757; PFAM: Phosphoribosyl transferase domain YP_004411091.1 KEGG: mxa:MXAN_2109 hyalin repeat-containing protein; SPTR: Hyalin repeat protein; IMG reference gene:2503956758 YP_004411092.1 KEGG: ssm:Spirs_2430 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956759 YP_004411093.1 COGs: COG0190 5 10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase; HAMAP: Tetrahydrofolate dehydrogenase/cyclohydrolase; InterPro IPR000672:IPR020630:IPR020631; KEGG: amu:Amuc_1641 methenyltetrahydrofolate cyclohydrolase; PFAM: Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; PRIAM: Methenyltetrahydrofolate cyclohydrolase; SPTR: Bifunctional protein folD; IMG reference gene:2503956760; PFAM: Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain YP_004411094.1 COGs: COG0621 2-methylthioadenine synthetase; InterProIPR013848:IPR007197:IPR005839:IPR006463:IPR 006638; KEGG: ssm:Spirs_2426 tRNA-i(6)A37 thiotransferase enzyme MiaB; PFAM: Methylthiotransferase, N-terminal; Radical SAM; SMART: Elongator protein 3/MiaB/NifB; SPTR: uncharacterized protein; TIGRFAM: tRNA-i(6)A37 modification enzyme MiaB; Methylthiotransferase; IMG reference gene:2503956761; PFAM: Radical SAM superfamily; Uncharacterized protein family UPF0004; TIGRFAM: tRNA-N(6)-(isopentenyl)adenosine-37 thiotransferase enzyme MiaB; radical SAM methylthiotransferase, MiaB/RimO family YP_004411095.1 COGs: COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase); InterPro IPR002198; KEGG: dtu:Dtur_1771 short-chain dehydrogenase/reductase SDR; PFAM: Short-chain dehydrogenase/reductase SDR; PRIAM: 3-oxoacyl-[acyl-carrier-protein] reductase; SPTR: Short-chain dehydrogenase/reductase SDR; IMG reference gene:2503956762; PFAM: short chain dehydrogenase YP_004411096.1 COGs: COG0846 NAD-dependent protein deacetylase SIR2 family; HAMAP: NAD-dependent histone deacetylase, silent information regulator Sir2; InterPro IPR003000; KEGG: mbu:Mbur_0627 silent information regulator protein Sir2; PFAM: NAD-dependent histone deacetylase, silent information regulator Sir2; SPTR: Silent information regulator protein Sir2; IMG reference gene:2503956763; PFAM: Sir2 family YP_004411097.1 KEGG: vsp:VS_II1427 hypothetical protein; SPTR: Nucleoside recognition domain protein; IMG reference gene:2503956765; PFAM: Nucleoside recognition YP_004411098.1 KEGG: dda:Dd703_2631 hypothetical protein; SPTR: Nucleoside recognition domain protein; IMG reference gene:2503956766; PFAM: Nucleoside recognition YP_004411099.1 COGs: COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase; InterPro IPR002933:IPR011650:IPR010168; KEGG: tpe:Tpen_1350 amidohydrolase; PFAM: Peptidase M20, dimerisation; Peptidase M20; SPTR: Amidohydrolase; TIGRFAM: Peptidase M20D, amidohydrolase; IMG reference gene:2503956767; PFAM: Peptidase dimerisation domain; TIGRFAM: amidohydrolase YP_004411100.1 KEGG: cdl:CDR20291_2752 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956768 YP_004411101.1 KEGG: oih:OB0952 hypothetical protein; SPTR: uncharacterized protein OB0952; IMG reference gene:2503956769 YP_004411102.1 COGs: COG1609 Transcriptional regulators; InterPro IPR000843:IPR001761; KEGG: msv:Mesil_0673 transcriptional regulator, LacI family; PFAM: Periplasmic binding protein/LacI transcriptional regulator; HTH transcriptional regulator, LacI; SMART: HTH transcriptional regulator, LacI; SPTR: Transcriptional regulator, LacI family; IMG reference gene:2503956770; PFAM: Bacterial regulatory proteins, lacI family; family YP_004411103.1 COGs: COG0395 ABC-type sugar transport system permease component; InterPro IPR000515; KEGG: gym:GYMC10_4741 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Binding-protein-dependent transport systems inner membrane component; IMG reference gene:2503956771; PFAM: Binding-protein-dependent transport system inner membrane component YP_004411104.1 COGs: COG4209 ABC-type polysaccharide transport system permease component; InterPro IPR000515; KEGG: gym:GYMC10_4742 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Binding-protein-dependent transport systems inner membrane component; IMG reference gene:2503956772; PFAM: Binding-protein-dependent transport system inner membrane component YP_004411105.1 COGs: COG1524 Uncharacterized protein of the AP superfamily; InterPro IPR002591; KEGG: bcv:Bcav_2459 type I phosphodiesterase/nucleotide pyrophosphatase; PFAM: Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase; SPTR: Type I phosphodiesterase/nucleotide pyrophosphatase; IMG reference gene:2503956773; PFAM: Type I phosphodiesterase / nucleotide pyrophosphatase YP_004411106.1 COGs: COG1387 Histidinol phosphatase and related hydrolase of the PHP family; InterPro IPR004013:IPR003141; KEGG: tko:TK0327 hypothetical protein; PFAM: PHP, C-terminal; SMART: Polymerase/histidinol phosphatase, N-terminal; SPTR: Phosphohydrolase, PHP family; IMG reference gene:2503956774; PFAM: PHP domain YP_004411107.1 COGs: COG0366 Glycosidase; InterPro IPR006047:IPR006589; KEGG: sta:STHERM_c12800 hypothetical protein; PFAM: Glycosyl hydrolase, family 13, catalytic domain; PRIAM: Sucrose phosphorylase; SMART: Glycosyl hydrolase, family 13, subfamily, catalytic domain; SPTR: uncharacterized protein; IMG reference gene:2503956775; PFAM: Alpha amylase, catalytic domain YP_004411108.1 KEGG: rrs:RoseRS_2835 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956776; PFAM: Protein of unknown function (DUF2961) YP_004411109.1 COGs: COG2333 hydrolase (metallo-beta-lactamase superfamily); InterPro IPR001279; KEGG: ppd:Ppro_1379 DNA internalization-related competence protein ComEC/Rec2; PFAM: Beta-lactamase-like; SMART: Beta-lactamase-like; SPTR: DNA internalization-related competence protein ComEC/Rec2; IMG reference gene:2503956777; PFAM: Metallo-beta-lactamase superfamily YP_004411110.1 COGs: COG1653 ABC-type sugar transport system periplasmic component; InterPro IPR006059; KEGG: gym:GYMC10_0760 extracellular solute-binding protein family 1; PFAM: Bacterial extracellular solute-binding, family 1; SPTR: Extracellular solute-binding protein family 1; IMG reference gene:2503956778; PFAM: Bacterial extracellular solute-binding protein YP_004411111.1 COGs: COG1802 Transcriptional regulators; InterPro IPR000524:IPR011711; KEGG: ssm:Spirs_0802 transcriptional regulator, GntR family; PFAM: HTH transcriptional regulator, GntR; GntR, C-terminal; SMART: HTH transcriptional regulator, GntR; GntR, C-terminal; SPTR: Transcriptional regulator, GntR family; IMG reference gene:2503956779; PFAM: Bacterial regulatory proteins, gntR family; FCD domain YP_004411112.1 COGs: COG0620 Methionine synthase II (cobalamin-independent); HAMAP: Cobalamin-independent methionine synthase; InterPro IPR006276:IPR013215:IPR002629; KEGG: swo:Swol_0933 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; PFAM: Methionine synthase, vitamin-B12 independent; Cobalamin (vitamin B12)-independent methionine synthase MetE, N-terminal; PRIAM:5-methyltetrahydropteroyltriglutamate--homocy steineS-methyltransferase; SPTR:5-methyltetrahydropteroyltriglutamate--homocys teinemethyltransferase; TIGRFAM: Cobalamin-independent methionine synthase; IMG reference gene:2503956780; PFAM: Cobalamin-independent synthase, N-terminal domain; Cobalamin-independent synthase, Catalytic domain; TIGRFAM: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase YP_004411113.1 COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171:IPR004620; KEGG: swo:Swol_0934 5,10-methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; PRIAM: Methylenetetrahydrofolate reductase (NAD(P)H); SPTR: Methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; IMG reference gene:2503956781; PFAM: Methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase, prokaryotic form YP_004411114.1 COGs: COG0583 Transcriptional regulator; InterPro IPR000847:IPR005119; KEGG: swo:Swol_0935 LysR-type transcriptional regulator; PFAM: HTH transcriptional regulator, LysR; LysR, substrate-binding; SPTR: LysR-type transcriptional regulator; IMG reference gene:2503956782; PFAM: Bacterial regulatory helix-turn-helix protein, lysR family; LysR substrate binding domain YP_004411115.1 KEGG: bhy:BHWA1_00761 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956783 YP_004411116.1 InterPro IPR006628; KEGG: ssm:Spirs_1866 PUR-alpha/beta/gamma DNA/RNA-binding protein; SMART: PUR-alpha/beta/gamma, DNA/RNA-binding; SPTR: uncharacterized protein; IMG reference gene:2503956784; PFAM: Protein of unknown function (DUF3276) YP_004411117.1 COGs: COG0164 Ribonuclease HII; InterPro IPR001352; KEGG: alv:Alvin_2058 ribonuclease H; PFAM: Ribonuclease HII/HIII; PRIAM: Ribonuclease H; SPTR: Ribonuclease; IMG reference gene:2503956785; PFAM: Ribonuclease HII YP_004411118.1 COGs: COG1196 Chromosome segregation ATPase; InterPro IPR003395; KEGG: ssm:Spirs_1868 chromosome segregation protein SMC; PFAM: RecF/RecN/SMC; SPTR: Chromosome partition protein SmC, ; IMG reference gene:2503956786; PFAM: RecF/RecN/SMC N terminal domain YP_004411119.1 COGs: COG0541 Signal recognition particle GTPase; InterProIPR013822:IPR000897:IPR004125:IPR004780:IPR 003593; KEGG: ssm:Spirs_1871 signal recognition particle protein; PFAM: Signal recognition particle, SRP54 subunit, GTPase; Signal recognition particle, SRP54 subunit, helical bundle; Signal recognition particle, SRP54 subunit, M-domain; SMART: Signal recognition particle, SRP54 subunit, GTPase; Signal recognition particle, SRP54 subunit, helical bundle; ATPase, AAA+ type, core; SPTR: Signal recognition particle protein; TIGRFAM: Signal recognition particle, SRP; IMG reference gene:2503956787; PFAM: SRP54-type protein, GTPase domain; SRP54-type protein, helical bundle domain; Signal peptide binding domain; TIGRFAM: signal recognition particle protein YP_004411120.1 COGs: COG0228 Ribosomal protein S16; HAMAP: Ribosomal protein S16; InterPro IPR000307; KEGG: ssm:Spirs_1872 ribosomal protein S16; PFAM: Ribosomal protein S16; SPTR: 30S ribosomal protein S16; TIGRFAM: Ribosomal protein S16; IMG reference gene:2503956788; PFAM: Ribosomal protein S16; TIGRFAM: ribosomal protein S16 YP_004411121.1 COGs: COG1837 RNA-binding protein (contains KH domain); HAMAP: Uncharacterised protein family UPF0109, bacterial; InterPro IPR020627; KEGG: ssm:Spirs_1873 R-binding protein (contains KH domain); SPTR: Nucleic acid binding protein, containing KH domain; IMG reference gene:2503956789; PFAM: KH domain YP_004411122.1 COGs: COG0806 RimM protein required for 16S rRNA processing; HAMAP: 16S rRNA processing protein RimM; InterPro IPR011961:IPR002676:IPR007903; KEGG: sta:STHERM_c10550 16S rRNA processing protein RimM; PFAM: RimM protein; PRC-barrel; SPTR: 16S rRNA processing protein RimM; TIGRFAM: 16S rRNA processing protein RimM; IMG reference gene:2503956790; PFAM: RimM N-terminal domain; TIGRFAM: 16S rRNA processing protein RimM YP_004411123.1 COGs: COG0336 tRNA-(guanine-N1)-methyltransferase; HAMAP: tRNA (guanine-N1-)-methyltransferase, bacteria; InterPro IPR002649:IPR016009; KEGG: ssm:Spirs_1875 tRNA (guanine-N1)-methyltransferase; PFAM: tRNA (guanine-N1-)-methyltransferase; PRIAM: tRNA (guanine-N(1)-)-methyltransferase; SPTR: tRNA (Guanine-N(1)-)-methyltransferase; TIGRFAM: tRNA (guanine-N1-)-methyltransferase, bacteria; IMG reference gene:2503956791; PFAM: tRNA (Guanine-1)-methyltransferase; TIGRFAM: tRNA (guanine-N1)-methyltransferase YP_004411124.1 COGs: COG0335 Ribosomal protein L19; HAMAP: Ribosomal protein L19; InterPro IPR001857; KEGG: ssm:Spirs_1876 ribosomal protein L19; PFAM: Ribosomal protein L19; SPTR: 50S ribosomal protein L19; TIGRFAM: Ribosomal protein L19; IMG reference gene:2503956792; PFAM: Ribosomal protein L19; TIGRFAM: ribosomal protein L19, bacterial type YP_004411125.1 COGs: COG0792 endonuclease distantly related to Holliday junction resolvase; HAMAP: Uncharacterised protein family UPF0102; InterPro IPR003509; KEGG: cyh:Cyan8802_3919 protein of unknown function UPF0102; PFAM: Uncharacterised protein family UPF0102; SPTR: UPF0102 protein Cyan8802_3919; IMG reference gene:2503956793; PFAM: Uncharacterised protein family UPF0102 YP_004411126.1 KEGG: tde:TDE2305 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956794 YP_004411127.1 COGs: COG0669 Phosphopantetheine adenylyltransferase; HAMAP: Coenzyme A biosynthesis protein; InterPro IPR001980:IPR004820:IPR004821; KEGG: ssm:Spirs_1886 pantetheine-phosphate adenylyltransferase; PFAM: Cytidylyltransferase; PRIAM: Pantetheine-phosphate adenylyltransferase; SPTR: Phosphopantetheine adenylyltransferase; TIGRFAM: Coenzyme A biosynthesis protein; Cytidyltransferase-related; IMG reference gene:2503956795; PFAM: Cytidylyltransferase; TIGRFAM: pantetheine-phosphate adenylyltransferase, bacterial; cytidyltransferase-related domain YP_004411128.1 COGs: COG0333 Ribosomal protein L32; HAMAP: Ribosomal protein L32p; InterPro IPR002677; KEGG: ssm:Spirs_1887 ribosomal protein L32; PFAM: Ribosomal protein L32p; SPTR: 50S ribosomal protein L32; TIGRFAM: Ribosomal protein L32p; IMG reference gene:2503956796; PFAM: Ribosomal L32p protein family; TIGRFAM: ribosomal protein L32 YP_004411129.1 COGs: COG0236 Acyl carrier protein; HAMAP: Acyl carrier protein (ACP); InterPro IPR003231:IPR006163; KEGG: sta:STHERM_c10660 hypothetical protein; PFAM: Phosphopantetheine-binding; SPTR: uncharacterized protein; TIGRFAM: Acyl carrier protein (ACP); IMG reference gene:2503956797; PFAM: Phosphopantetheine attachment site; TIGRFAM: acyl carrier protein YP_004411130.1 COGs: COG0571 dsRNA-specific ribonuclease; HAMAP: Ribonuclease III, bacterial; InterPro IPR011907:IPR000999:IPR001159; KEGG: ssm:Spirs_1889 ribonuclease III; PFAM: Ribonuclease III; Double-stranded RNA-binding; PRIAM: Ribonuclease III; SMART: Ribonuclease III; Double-stranded RNA-binding; SPTR: Ribonuclease 3; TIGRFAM: Ribonuclease III, bacterial; IMG reference gene:2503956798; PFAM: RNase3 domain; Double-stranded RNA binding motif; TIGRFAM: ribonuclease III, bacterial YP_004411131.1 COGs: COG0617 tRNA nucleotidyltransferase/poly(A) polymerase; InterPro IPR002646:IPR006674:IPR006675; KEGG: ssm:Spirs_1890 polynucleotide adenylyltransferase/metal dependent phosphohydrolase; PFAM: Poly A polymerase, head domain; Metal-dependent phosphohydrolase, HD subdomain; PRIAM: tRNA cytidylyltransferase; SPTR: tRNA adenylyltransferase; TIGRFAM: Uncharacterised protein family HDIG; IMG reference gene:2503956799; PFAM: HD domain; Poly A polymerase head domain YP_004411132.1 COGs: COG0060 Isoleucyl-tRNA synthetase; HAMAP: Isoleucyl-tRNA synthetase, class Ia; InterPro IPR002301:IPR002300:IPR013155; KEGG: ssm:Spirs_1894 isoleucyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class Ia; Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding; PRIAM: Isoleucine--tRNA ligase; SPTR: Isoleucyl-tRNA synthetase; TIGRFAM: Isoleucyl-tRNA synthetase, class Ia; IMG reference gene:2503956800; PFAM: tRNA synthetases class I (I, L, M and V); Anticodon-binding domain; TIGRFAM: isoleucyl-tRNA synthetase YP_004411133.1 KEGG: tbd:Tbd_1366 diguanylate cyclase/phosphodiesterase; SPTR: diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S); IMG reference gene:2503956801 YP_004411134.1 COGs: COG0301 Thiamine biosynthesis ATP pyrophosphatase; HAMAP: Thiamine biosynthesis protein; InterPro IPR003720:IPR004114:IPR020536; KEGG: ssm:Spirs_1899 thiamine biosynthesis/tRNA modification protein ThiI; PFAM: Thiamine biosynthesis protein, C-terminal; THUMP; SMART: THUMP; SPTR: Probable thiamine biosynthesis protein ThiI; TIGRFAM: Thiamine biosynthesis protein; IMG reference gene:2503956802; PFAM: Thiamine biosynthesis protein (ThiI); THUMP domain; TIGRFAM: thiazole biosynthesis/tRNA modification protein ThiI YP_004411135.1 COGs: COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase; InterPro IPR000192; KEGG: sta:STHERM_c15870 cysteine desulfurase; PFAM: Aminotransferase, class V/Cysteine desulfurase; PRIAM: Cysteine desulfurase; SPTR: Cysteine desulfurase; IMG reference gene:2503956803; PFAM: Aminotransferase class-V YP_004411136.1 COGs: COG0337 3-dehydroquinate synthetase; InterPro IPR002658; KEGG: ssm:Spirs_1902 3-dehydroquinate synthase; PFAM: 3-dehydroquinate synthase AroB; PRIAM: 3-dehydroquinate synthase; SPTR: 3-dehydroquinate synthase; IMG reference gene:2503956804; PFAM: 3-dehydroquinate synthase YP_004411137.1 COGs: COG1643 HrpA-like helicase; InterPro IPR001650:IPR007502:IPR011709:IPR014001; KEGG: ssm:Spirs_1903 protein of unknown function DUF1605; PFAM: Domain of unknown function DUF1605; Helicase-associated domain; Helicase, C-terminal; SMART: DEAD-like helicase, N-terminal; Helicase, C-terminal; Helicase-associated domain; SPTR: uncharacterized protein; IMG reference gene:2503956805; PFAM: Helicase conserved C-terminal domain; Helicase associated domain (HA2); DEAD/DEAH box helicase; Domain of unknown function (DUF1605); TIGRFAM: ATP-dependent helicase HrpA YP_004411138.1 COGs: COG0124 Histidyl-tRNA synthetase; HAMAP: Histidyl-tRNA synthetase, class IIa, subgroup; InterPro IPR015807:IPR002314:IPR004154; KEGG: ssm:Spirs_1904 histidyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain; Anticodon-binding; PRIAM: Histidine--tRNA ligase; SPTR: Histidyl-tRNA synthetase; TIGRFAM: Histidyl-tRNA synthetase, class IIa, subgroup; IMG reference gene:2503956806; PFAM: Anticodon binding domain; tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: histidyl-tRNA synthetase YP_004411139.1 COGs: COG0617 tRNA nucleotidyltransferase/poly(A) polymerase; InterPro IPR002646:IPR010206; KEGG: ssm:Spirs_1905 poly(A) polymerase; PFAM: Poly A polymerase, head domain; PRIAM: Polynucleotide adenylyltransferase; SPTR: PolyA polymerase; TIGRFAM: Poly(A) polymerase, PcnB; IMG reference gene:2503956807; PFAM: Poly A polymerase head domain; TIGRFAM: poly(A) polymerase YP_004411140.1 KEGG: ssm:Spirs_1907 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956808 YP_004411141.1 COGs: COG4656 NADH:ubiquinone oxidoreductase subunit RnfC; InterPro IPR011538:IPR019554:IPR001450:IPR010208; KEGG: ssm:Spirs_1909 electron transport complex, RnfABCDGE type, C subunit; PFAM: NADH:ubiquinone oxidoreductase, 51kDa subunit; Soluble ligand binding domain; 4Fe-4S binding domain; SPTR: Transporter; TIGRFAM: Electron transport complex, RnfC; manually curated; IMG reference gene:2503956809; PFAM: Respiratory-chain NADH dehydrogenase 51 Kd subunit; SLBB domain; TIGRFAM: electron transport complex, RnfABCDGE type, C subunit YP_004411142.1 COGs: COG4658 NADH:ubiquinone oxidoreductase subunit RnfD; InterPro IPR004338:IPR011303; KEGG: ssm:Spirs_1910 electron transport complex, RnfABCDGE type, D subunit; PFAM: NADH-quinone reductase NQR2/RnfD; SPTR: Electron transport complex, D subunit; TIGRFAM: Electron transport complex, RnfD; IMG reference gene:2503956810; PFAM: NQR2, RnfD, RnfE family YP_004411143.1 InterPro IPR007329; KEGG: ssm:Spirs_1911 FMN-binding domain protein; PFAM: FMN-binding; SMART: FMN-binding; SPTR: Electron transport complex, rnfabcdGe type, g subunit; IMG reference gene:2503956811; PFAM: FMN-binding domain YP_004411144.1 COGs: COG4660 NADH:ubiquinone oxidoreductase subunit RnfE; InterPro IPR003667; KEGG: ssm:Spirs_1912 electron transport complex, RnfABCDGE type, E subunit; PFAM: Electron transport complex, Rnf/Nqr; SPTR: Electron transport complex, RnfABCDGE type, E subunit; IMG reference gene:2503956812; PFAM: Rnf-Nqr subunit, membrane protein YP_004411145.1 COGs: COG4657 NADH:ubiquinone oxidoreductase subunit RnfA; KEGG: ssm:Spirs_1913 electron transport complex, RnfABCDGE type, A subunit; SPTR: Na(+)-translocating NADH-quinone reductase subunit E; IMG reference gene:2503956813; PFAM: Rnf-Nqr subunit, membrane protein YP_004411146.1 InterPro IPR004300:IPR015179; KEGG: ssm:Spirs_1915 4-alpha-glucanotransferase; PFAM: Glycoside hydrolase, family 57, N-terminal; Alpha-amylase/4-alpha-glucanotransferase, C-terminal; SPTR: 4-alpha-glucanotransferase; IMG reference gene:2503956814; PFAM: Glycosyl hydrolase 57; Domain of unknown function (DUF1926) YP_004411147.1 KEGG: bfa:Bfae_13220 4-alpha-glucanotransferase; SPTR: Peptide chain release factor 2; manually curated; IMG reference gene:2503956815; PFAM: PCRF domain; RF-1 domain; TIGRFAM: peptide chain release factor 2 YP_004411148.1 KEGG: mhu:Mhun_2300 PEGA; SPTR: PEGA; IMG reference gene:2503956816 YP_004411149.1 COGs: COG0552 Signal recognition particle GTPase; InterPro IPR013822:IPR000897:IPR004390:IPR003593; KEGG: ssm:Spirs_1921 signal recognition particle-docking protein FtsY; PFAM: Signal recognition particle, SRP54 subunit, GTPase; Signal recognition particle, SRP54 subunit, helical bundle; SMART: Signal recognition particle, SRP54 subunit, GTPase; ATPase, AAA+ type, core; Signal recognition particle, SRP54 subunit, helical bundle; SPTR: Signal recognition particle-docking protein FtsY; TIGRFAM: Cell division transporter substrate-binding protein FtsY; IMG reference gene:2503956817; PFAM: SRP54-type protein, GTPase domain; SRP54-type protein, helical bundle domain; TIGRFAM: signal recognition particle-docking protein FtsY YP_004411150.1 COGs: COG4591 ABC-type transport system involved in lipoprotein release permease component; InterPro IPR003838; KEGG: sta:STHERM_c12430 lipoprotein releasing system, permease; PFAM: Domain of unknown function DUF214, ABC transporter permease; SPTR: lipoprotein releasing system, permease; IMG reference gene:2503956818; PFAM: Predicted permease YP_004411151.1 COGs: COG1136 ABC-type antimicrobial peptide transport system ATPase component; InterPro IPR003439:IPR003593; KEGG: sta:STHERM_c12420 lipoprotein-releasing system ATP-binding protein LolD; PFAM: ABC transporter-like; PRIAM: Phosphonate-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: Lipoprotein-releasing system ATP-binding protein LolD; IMG reference gene:2503956819; PFAM: ABC transporter YP_004411152.1 COGs: COG4591 ABC-type transport system involved in lipoprotein release permease component; InterPro IPR003838; KEGG: ssm:Spirs_1925 protein of unknown function DUF214; PFAM: Domain of unknown function DUF214, ABC transporter permease; SPTR: Lipoprotein releasing system, transmembrane protein, LolC/E family; IMG reference gene:2503956820; PFAM: Predicted permease YP_004411153.1 COGs: COG1234 Metal-dependent hydrolase of the beta-lactamase superfamily III; HAMAP: Ribonuclease Z; InterPro IPR013471:IPR001279; KEGG: tde:TDE1951 ribonuclease Z; PFAM: Beta-lactamase-like; SPTR: Ribonuclease Z; TIGRFAM: Ribonuclease Z; IMG reference gene:2503956821; PFAM: Metallo-beta-lactamase superfamily; TIGRFAM: ribonuclease Z YP_004411154.1 KEGG: mdi:METDI2989 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956822 YP_004411155.1 InterPro IPR007060; KEGG: pay:PAU_00273 hypothetical protein; PFAM: Septum formation initiator; SPTR: uncharacterized protein; IMG reference gene:2503956823 YP_004411156.1 COGs: COG0009 translation factor (SUA5); InterPro IPR006070; KEGG: ssm:Spirs_1938 SUA5/YciO/YrdC/YwlC family protein; PFAM: Sua5/YciO/YrdC, N-terminal; SPTR: Sua5/YciO/YrdC/YwlC family protein; IMG reference gene:2503956824; PFAM: yrdC domain; TIGRFAM: Sua5/YciO/YrdC/YwlC family protein YP_004411157.1 InterPro IPR008323; KEGG: ssm:Spirs_1939 hypothetical protein; PFAM: Uncharacterised conserved protein UCP033563; SPTR: uncharacterized protein; IMG reference gene:2503956825; PFAM: Protein of unknown function (DUF1015) YP_004411158.1 COGs: COG1564 Thiamine pyrophosphokinase; InterPro IPR007371:IPR006282; KEGG: ssm:Spirs_1940 thiamine pyrophosphokinase; PFAM: Thiamin pyrophosphokinase, catalytic domain; SPTR: uncharacterized protein; TIGRFAM: Thiamin pyrophosphokinase; IMG reference gene:2503956826; PFAM: Thiamin pyrophosphokinase, vitamin B1 binding domain; Thiamin pyrophosphokinase, catalytic domain; TIGRFAM: thiamine pyrophosphokinase YP_004411159.1 KEGG: cff:CFF8240_1387 polysaccharide biosynthesis protein; SPTR: Polysaccharide biosynthesis protein; IMG reference gene:2503956827 YP_004411160.1 COGs: COG4401 Chorismate mutase; InterPro IPR008243; KEGG: chy:CHY_0473 chorismate mutase; PFAM: Chorismate mutase, AroH class; SPTR: Chorismate mutase; TIGRFAM: Chorismate mutase, AroH class; IMG reference gene:2503956828; PFAM: Chorismate mutase type I; TIGRFAM: monofunctional chorismate mutase, gram positive type, clade 1 YP_004411161.1 KEGG: fbl:Fbal_1981 ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydD; SPTR: Transport ATP-binding protein aarD; IMG reference gene:2503956830 YP_004411162.1 COGs: COG0338 Site-specific DNA methylase; InterPro IPR012327; KEGG: lba:Lebu_2246 DNA adenine methylase; PFAM: D12 class N6 adenine-specific DNA methyltransferase; SPTR: DNA adenine methylase; TIGRFAM: D12 class N6 adenine-specific DNA methyltransferase; IMG reference gene:2503956831; PFAM: D12 class N6 adenine-specific DNA methyltransferase; TIGRFAM: DNA adenine methylase (dam) YP_004411163.1 InterPro IPR007637; KEGG: eel:EUBELI_01767 type II restriction enzyme; PFAM: Restriction endonuclease, type II, DpmII-like; PRIAM: Type II site-specific deoxyribonuclease; SPTR: Type II site-specific deoxyribonuclease; IMG reference gene:2503956832; PFAM: DpnII restriction endonuclease YP_004411164.1 COGs: COG1041 DNA modification methylase; InterPro IPR002941; KEGG: lba:Lebu_2245 RNA methylase; PFAM: DNA methylase N-4/N-6; SPTR: DNA methylase N-4/N-6 domain protein; IMG reference gene:2503956833; PFAM: DNA methylase YP_004411165.1 COGs: COG3070 Regulator of competence-specific genes; InterPro IPR007076; KEGG: pru:PRU_2356 TfoX N-terminal domain-containing protein; PFAM: TfoX, N-terminal; SPTR: uncharacterized protein; tmRNA as predicted by Rfam (RF00023), score 166.26; IMG reference gene:2503956834; PFAM: TfoX N-terminal domain YP_004411166.1 COGs: COG0583 Transcriptional regulator; InterPro IPR000847:IPR005119; KEGG: str:Sterm_1975 transcriptional regulator, LysR family; PFAM: HTH transcriptional regulator, LysR; LysR, substrate-binding; SPTR: uncharacterized protein; IMG reference gene:2503956835; PFAM: Bacterial regulatory helix-turn-helix protein, lysR family; LysR substrate binding domain YP_004411167.1 COGs: COG0656 Aldo/keto reductase related to diketogulonate reductase; InterPro IPR023210; KEGG: ssm:Spirs_1777 aldo/keto reductase; PFAM: NADP-dependent oxidoreductase domain; PRIAM: 2,5-didehydrogluconate reductase; SPTR: uncharacterized protein; IMG reference gene:2503956836; PFAM: Aldo/keto reductase YP_004411168.1 KEGG: shi:Shel_18140 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956837 YP_004411169.1 COGs: COG0110 Acetyltransferase (isoleucine patch superfamily); InterPro IPR001451; KEGG: cgr:CAGL0K11066g hypothetical protein; PRIAM: Maltose O-acetyltransferase; SPTR: Maltose O-acetyltransferase; IMG reference gene:2503956838; PFAM: Bacterial transferase hexapeptide (three repeats) YP_004411170.1 COGs: COG0655 Multimeric flavodoxin WrbA; InterPro IPR005025; KEGG: brm:Bmur_2381 NADPH-dependent FMN reductase; PFAM: NADPH-dependent FMN reductase; SPTR: uncharacterized protein; IMG reference gene:2503956839; PFAM: NADPH-dependent FMN reductase YP_004411171.1 InterPro IPR001647; KEGG: cpy:Cphy_1864 TetR family transcriptional regulator; PFAM: Transcription regulator, TetR-like, DNA-binding, bacterial/archaeal; SPTR: Transcriptional regulator, TetR family; IMG reference gene:2503956840; PFAM: Bacterial regulatory proteins, tetR family YP_004411172.1 COGs: COG3976 conserved hypothetical protein; InterPro IPR007329; KEGG: cbe:Cbei_3767 FMN-binding domain-containing protein; PFAM: FMN-binding; SMART: FMN-binding; SPTR: FMN-binding domain protein; IMG reference gene:2503956841; PFAM: FMN-binding domain YP_004411173.1 KEGG: str:Sterm_3493 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956842 YP_004411174.1 KEGG: lcz:LCAZH_2061 sucrose PTS, EIIBCA; SPTR: uncharacterized protein; IMG reference gene:2503956843 YP_004411175.1 COGs: COG1131 ABC-type multidrug transport system ATPase component; InterPro IPR003439:IPR003593; KEGG: btl:BALH_2607 ABC transporter, ATP-binding protein; PFAM: ABC transporter-like; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter; IMG reference gene:2503956844 YP_004411176.1 KEGG: bth:BT_4430 cytochrome c biogenesis protein (CcsA); SPTR: Permease; IMG reference gene:2503956845 YP_004411177.1 COGs: COG4832 conserved hypothetical protein; InterPro IPR019233; KEGG: mla:Mlab_0505 hypothetical protein; PFAM: Protein of unknown function DUF2174, N-terminal; SPTR: uncharacterized protein; IMG reference gene:2503956846; PFAM: Uncharacterized conserved protein (DUF2174) YP_004411178.1 COGs: COG3871 Uncharacterized stress protein (general stress protein 26); InterPro IPR011576; KEGG: bth:BT_1384 hypothetical protein; PFAM: Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain; SPTR: uncharacterized protein; IMG reference gene:2503956847; PFAM: Pyridoxamine 5'-phosphate oxidase YP_004411179.1 COGs: COG4898 conserved hypothetical protein; InterPro IPR014580; KEGG: dae:Dtox_0463 hypothetical protein; PFAM: Uncharacterised conserved protein UCP033199; SPTR: uncharacterized protein; IMG reference gene:2503956848; PFAM: Uncharacterized protein conserved in bacteria (DUF2200) YP_004411180.1 COGs: COG5621 secreted hydrolase; KEGG: ckr:CKR_2552 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956849; PFAM: Hydroxyneurosporene synthase (CrtC) YP_004411181.1 KEGG: ols:Olsu_1506 nitroreductase; SPTR: uncharacterized protein; IMG reference gene:2503956850 YP_004411182.1 COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR013027:IPR006005; KEGG: pdi:BDI_0325 glutamate synthase, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PRIAM: Glutamate synthase (NADPH); SPTR: Glutamate synthase, small subunit; TIGRFAM: Glutamate synthase, NADH/NADPH, small subunit 1; IMG reference gene:2503956851; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: glutamate synthases, NADH/NADPH, small subunit YP_004411183.1 COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583:IPR006982:IPR002932:IPR002489; KEGG: pdi:BDI_0326 glutamate synthase, large subunit; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase, large subunit; IMG reference gene:2503956852; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II YP_004411184.1 COGs: COG1959 transcriptional regulator protein; InterPro IPR000944; KEGG: dsy:DSY4193 hypothetical protein; PFAM: Transcription regulator Rrf2; SPTR: uncharacterized protein; TIGRFAM: Transcription regulator Rrf2; IMG reference gene:2503956853; PFAM: Transcriptional regulator; TIGRFAM: Rrf2 family protein YP_004411185.1 COGs: COG1959 transcriptional regulator protein; InterPro IPR000944; KEGG: cce:Ccel_1933 transcriptional regulator, BadM/Rrf2 family; PFAM: Transcription regulator Rrf2; SPTR: Transcriptional regulator, BadM/Rrf2 family; TIGRFAM: Transcription regulator Rrf2; IMG reference gene:2503956854; PFAM: Transcriptional regulator; TIGRFAM: Rrf2 family protein YP_004411186.1 COGs: COG0300 Short-chain dehydrogenase of various substrate specificities; InterPro IPR002198; KEGG: cak:Caul_2944 short-chain dehydrogenase/reductase SDR; PFAM: Short-chain dehydrogenase/reductase SDR; SPTR: Oxidoreductase, short chain dehydrogenase/reductase; IMG reference gene:2503956855; PFAM: short chain dehydrogenase YP_004411187.1 COGs: COG4974 Site-specific recombinase XerD; InterPro IPR002104; KEGG: ssm:Spirs_2778 integrase; PFAM: Integrase, catalytic core, phage; SPTR: Lj965 prophage integrase; IMG reference gene:2503956856; PFAM: Phage integrase YP_004411188.1 COGs: COG0691 tmRNA-binding protein; HAMAP: SsrA-binding protein; InterPro IPR000037; KEGG: ssm:Spirs_2009 SsrA-binding protein; PFAM: SsrA-binding protein; SPTR: SsrA-binding protein; TIGRFAM: SsrA-binding protein; IMG reference gene:2503956857; PFAM: SmpB protein; TIGRFAM: SsrA-binding protein YP_004411189.1 COGs: COG1262 conserved hypothetical protein; InterPro IPR005532; KEGG: ssm:Spirs_2010 protein of unknown function DUF323; PFAM: Sulphatase-modifying factor; SPTR: uncharacterized protein; IMG reference gene:2503956858; PFAM: Formylglycine-generating sulfatase enzyme YP_004411190.1 InterPro IPR019759:IPR000223; KEGG: ssm:Spirs_2011 signal peptidase I; PFAM: Peptidase S24/S26A/S26B, conserved region; SPTR: Signal peptidase I; TIGRFAM: Peptidase S26A, signal peptidase I; IMG reference gene:2503956859; PFAM: Peptidase S26; TIGRFAM: signal peptidase I, bacterial type YP_004411191.1 COGs: COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductase; InterPro IPR007197:IPR010723:IPR004559:IPR006638; KEGG: dba:Dbac_3351 oxygen-independent coproporphyrinogen III oxidase; PFAM: HemN, C-terminal; Radical SAM; SMART: Elongator protein 3/MiaB/NifB; SPTR: Oxygen-independent coproporphyrinogen III oxidase; TIGRFAM: oxygen-independent coproporphyrinogen III oxidase; IMG reference gene:2503956860; PFAM: Radical SAM superfamily; HemN C-terminal region; TIGRFAM: oxygen-independent coproporphyrinogen III oxidase YP_004411192.1 COGs: COG0217 conserved hypothetical protein; HAMAP: Protein of unknown function DUF28; InterPro IPR002876; KEGG: ssm:Spirs_2014 protein of unknown function DUF28; PFAM: Protein of unknown function DUF28; SPTR: uncharacterized protein; TIGRFAM: Protein of unknown function DUF28; IMG reference gene:2503956861; PFAM: Domain of unknown function DUF28; TIGRFAM: DNA-binding regulatory protein, YebC/PmpR family YP_004411193.1 COGs: COG0817 Holliday junction resolvasome endonuclease subunit; HAMAP: Crossover junction endodeoxyribonuclease RuvC; InterPro IPR002176; KEGG: ssm:Spirs_2015 crossover junction endodeoxyribonuclease RuvC; PFAM: Crossover junction endodeoxyribonuclease RuvC; PRIAM: Crossover junction endodeoxyribonuclease; SPTR: Crossover junction endodeoxyribonuclease ruvC; TIGRFAM: Crossover junction endodeoxyribonuclease RuvC; IMG reference gene:2503956862; PFAM: Crossover junction endodeoxyribonuclease RuvC; TIGRFAM: crossover junction endodeoxyribonuclease RuvC YP_004411194.1 COGs: COG0632 Holliday junction resolvasome DNA-binding subunit; HAMAP: Bacterial DNA recombination protein RuvA; InterPro IPR000085:IPR013849:IPR003583; KEGG: tpp:TPASS_0543 Holliday junction DNA helicase, subunit A; PFAM: DNA helicase, Holliday junction RuvA type, domain I, bacterial; SPTR: Holliday junction ATP-dependent DNA helicase ruvA; TIGRFAM: Bacterial DNA recombination protein RuvA; IMG reference gene:2503956863; PFAM: RuvA N terminal domain; TIGRFAM: Holliday junction DNA helicase, RuvA subunit YP_004411195.1 COGs: COG2255 Holliday junction resolvasome helicase subunit; HAMAP: DNA helicase, Holliday junction RuvB type; InterProIPR004605:IPR008824:IPR003959:IPR008823:IPR 003593; KEGG: ssm:Spirs_2017 Holliday junction DNA helicase RuvB; PFAM: DNA helicase, Holliday junction RuvB type, C-terminal; ATPase, AAA-type, core; DNA helicase, Holliday junction RuvB type, N-terminal; SMART: ATPase, AAA+ type, core; SPTR: Holliday junction ATP-dependent DNA helicase ruvB; TIGRFAM: DNA helicase, Holliday junction RuvB type; IMG reference gene:2503956864; PFAM: Holliday junction DNA helicase ruvB C-terminus; Holliday junction DNA helicase ruvB N-terminus; TIGRFAM: Holliday junction DNA helicase, RuvB subunit YP_004411196.1 COGs: COG0809 S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase); HAMAP: Queuosine biosynthesis protein; InterPro IPR003699; KEGG: ssm:Spirs_2018 S-adenosylmethionine/tRNA-ribosyltransferase-iso merase; PFAM: Queuosine biosynthesis protein; SPTR: S-adenosylmethionine:tRNA ribosyltransferase-isomerase; TIGRFAM: Queuosine biosynthesis protein; IMG reference gene:2503956865; PFAM: Queuosine biosynthesis protein; TIGRFAM: S-adenosylmethionine:tRNA ribosyltransferase-isomerase YP_004411197.1 COGs: COG0125 Thymidylate kinase; HAMAP: Thymidylate kinase; InterPro IPR018094; KEGG: tpp:TPASS_0354 thymidylate kinase; PFAM: Thymidylate kinase; PRIAM: dTMP kinase; SPTR: Thymidylate kinase; TIGRFAM: Thymidylate kinase; IMG reference gene:2503956866; PFAM: Thymidylate kinase; TIGRFAM: thymidylate kinase YP_004411198.1 InterPro IPR007452; KEGG: ssm:Spirs_2021 protein of unknown function DUF490; PFAM: Protein of unknown function DUF490; SPTR: uncharacterized protein; IMG reference gene:2503956867; PFAM: Family of unknown function (DUF490) YP_004411199.1 COGs: COG4775 Outer membrane protein/protective antigen OMA87; InterPro IPR010827:IPR000184:IPR016474; KEGG: ssm:Spirs_2022 outer membrane protein assembly complex, YaeT protein; PFAM: Bacterial surface antigen (D15); Surface antigen variable number; SPTR: surface antigen; TIGRFAM: Outer membrane assembly protein, YaeT; IMG reference gene:2503956868; PFAM: Surface antigen variable number repeat; Surface antigen; TIGRFAM: outer membrane protein assembly complex, YaeT protein YP_004411200.1 COGs: COG0249 Mismatch repair ATPase (MutS family); HAMAP: DNA mismatch repair protein MutS, type 1; InterProIPR005748:IPR007695:IPR007860:IPR007696:IPR 007861:IPR000432; KEGG: ssm:Spirs_2024 DNA mismatch repair protein MutS; PFAM: DNA mismatch repair protein MutS, C-terminal; DNA mismatch repair protein MutS-like, N-terminal; DNA mismatch repair protein MutS, connector; DNA mismatch repair protein MutS, core; DNA mismatch repair protein MutS, clamp; SMART: DNA mismatch repair protein MutS, C-terminal; DNA mismatch repair protein MutS, core; SPTR: DNA mismatch repair protein MutS; TIGRFAM: DNA mismatch repair protein MutS, type 1; IMG reference gene:2503956869; PFAM: MutS family domain IV; MutS domain II; MutS domain V; MutS domain I; MutS domain III; TIGRFAM: DNA mismatch repair protein MutS YP_004411201.1 COGs: COG1040 amidophosphoribosyltransferase; KEGG: ele:Elen_1211 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956870 YP_004411202.1 HAMAP: Ribosome maturation factor RimP; InterPro IPR003728; KEGG: sta:STHERM_c11200 hypothetical protein; PFAM: Ribosome maturation factor RimP; SPTR: uncharacterized protein; IMG reference gene:2503956871; PFAM: Uncharacterised BCR, YhbC family COG0779 YP_004411203.1 COGs: COG0195 Transcription elongation factor; InterProIPR013735:IPR003029:IPR010213:IPR022967:IPR 004087; KEGG: ssm:Spirs_2027 transcription termination factor NusA; PFAM: Transcription factor NusA, N-terminal; Ribosomal protein S1, RNA-binding domain; SMART: RNA-binding domain, S1; K Homology; SPTR: uncharacterized protein; TIGRFAM: Transcription termination factor NusA; IMG reference gene:2503956872; PFAM: NusA N-terminal domain; S1 RNA binding domain; Mitochondrial ribosomal protein MRP-S35; TIGRFAM: transcription termination factor NusA YP_004411204.1 COGs: COG0532 Translation initiation factor 2 (IF-2; GTPase); InterProIPR006847:IPR000795:IPR004161:IPR000178:IPR 005225; KEGG: ssm:Spirs_2028 translation initiation factor IF-2; PFAM: Protein synthesis factor, GTP-binding; Translation initiation factor IF-2, N-terminal; Translation elongation factor EFTu/EF1A, domain 2; SPTR: Translation initiation factor IF-2; TIGRFAM: Translation initiation factor aIF-2, bacterial-like; Small GTP-binding protein; IMG reference gene:2503956873; PFAM: Elongation factor Tu domain 2; Translation-initiation factor 2; Translation initiation factor IF-2, N-terminal region; Elongation factor Tu GTP binding domain; TIGRFAM: small GTP-binding protein domain; translation initiation factor IF-2 YP_004411205.1 COGs: COG0858 Ribosome-binding factor A; HAMAP: Ribosome-binding factor A; InterPro IPR000238; KEGG: ssm:Spirs_2029 ribosome-binding factor A; PFAM: Ribosome-binding factor A; SPTR: Ribosome-binding factor A; TIGRFAM: Ribosome-binding factor A; IMG reference gene:2503956874; PFAM: Ribosome-binding factor A; TIGRFAM: ribosome-binding factor A YP_004411206.1 COGs: COG0130 Pseudouridine synthase; HAMAP: tRNA pseudouridine synthase II, TruB; InterPro IPR014780:IPR002501; KEGG: sta:STHERM_c11160 tRNA pseudouridine 55 synthase; PFAM: Pseudouridine synthase II; SPTR: tRNA pseudouridine 55 synthase; TIGRFAM: tRNA pseudouridine synthase II, TruB; IMG reference gene:2503956875; PFAM: TruB family pseudouridylate synthase (N terminal domain); TIGRFAM: tRNA pseudouridine 55 synthase YP_004411207.1 COGs: COG0196 FAD synthase; InterPro IPR015864; KEGG: sta:STHERM_c11150 riboflavin biosynthesis protein RibF; PFAM: FAD synthetase; SPTR: Riboflavin biosynthesis protein RibF; IMG reference gene:2503956876; PFAM: FAD synthetase YP_004411208.1 COGs: COG0184 Ribosomal protein S15P/S13E; InterPro IPR000589:IPR005290; KEGG: ssm:Spirs_2032 ribosomal protein S15; PFAM: Ribosomal protein S15; SPTR: 30S ribosomal protein S15; TIGRFAM: Ribosomal protein S15, bacterial-type; IMG reference gene:2503956877; PFAM: Ribosomal protein S15; TIGRFAM: ribosomal protein S15, bacterial/organelle YP_004411209.1 COGs: COG1185 Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase); HAMAP: Polyribonucleotide nucleotidyltransferase; InterProIPR012162:IPR001247:IPR015847:IPR015848:IPR 018111:IPR003029:IPR004087:IPR022967; KEGG: ssm:Spirs_2033 polyribonucleotide nucleotidyltransferase; PFAM: Exoribonuclease, phosphorolytic domain 1; Exoribonuclease, phosphorolytic domain 2; Polynucleotide phosphorylase, phosphorolytic RNA-binding, bacterial/organelle-type; K Homology, type 1, subgroup; Ribosomal protein S1, RNA-binding domain; PRIAM: Polyribonucleotide nucleotidyltransferase; SMART: RNA-binding domain, S1; K Homology; SPTR: Polyribonucleotide nucleotidyltransferase; TIGRFAM: Polyribonucleotide nucleotidyltransferase; IMG reference gene:2503956878; PFAM: KH domain; S1 RNA binding domain; 3' exoribonuclease, domain 1; 3' exoribonuclease, domain 2; Polyribonucleotide nucleotidyltransferase, RNA binding domain; TIGRFAM: polyribonucleotide nucleotidyltransferase YP_004411210.1 COGs: COG0756 dUTPase; HAMAP: DeoxyUTP pyrophosphatase; InterPro IPR008181:IPR008180; KEGG: rpc:RPC_0381 deoxyuridine 5'-triphosphate nucleotidohydrolase; PFAM: DeoxyUTP pyrophosphatase domain; PRIAM: dUTP diphosphatase; SPTR: Deoxyuridine 5'-triphosphate nucleotidohydrolase; TIGRFAM: DeoxyUTP pyrophosphatase; IMG reference gene:2503956879; PFAM: dUTPase; TIGRFAM: deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) YP_004411211.1 COGs: COG0795 permease; InterPro IPR005495; KEGG: sta:STHERM_c11120 hypothetical protein; PFAM: Permease YjgP/YjgQ, predicted; SPTR: uncharacterized protein; IMG reference gene:2503956880; PFAM: Predicted permease YjgP/YjgQ family YP_004411212.1 COGs: COG0795 permease; InterPro IPR005495; KEGG: sta:STHERM_c11110 permease YjgP/YjgQ family protein; PFAM: Permease YjgP/YjgQ, predicted; SPTR: Permease YjgP/YjgQ family protein; IMG reference gene:2503956881; PFAM: Predicted permease YjgP/YjgQ family YP_004411213.1 COGs: COG0343 Queuine/archaeosine tRNA-ribosyltransferase; HAMAP: Queuine tRNA-ribosyltransferase; InterPro IPR004803:IPR002616; KEGG: ssm:Spirs_2037 queuine tRNA-ribosyltransferase; PFAM: Queuine/other tRNA-ribosyltransferase; PRIAM: tRNA-guanine transglycosylase; SPTR: Queuine tRNA-ribosyltransferase; TIGRFAM: Queuine tRNA-ribosyltransferase; Queuine/other tRNA-ribosyltransferase; IMG reference gene:2503956882; PFAM: Queuine tRNA-ribosyltransferase; TIGRFAM: tRNA-guanine transglycosylases, various specificities; tRNA-guanine transglycosylase, queuosine-34-forming YP_004411214.1 COGs: COG0728 membrane protein virulence factor; InterPro IPR004268; KEGG: sta:STHERM_c11090 virulence factor MviN; PFAM: Flagellin assembly, membrane protein MviN; SPTR: Virulence factor MviN; TIGRFAM: Flagellin assembly, membrane protein MviN; IMG reference gene:2503956883; PFAM: MviN-like protein; TIGRFAM: integral membrane protein MviN YP_004411215.1 COGs: COG1747 Uncharacterized N-terminal domain of the transcription elongation factor GreA; InterPro IPR022691:IPR001437; KEGG: ssm:Spirs_2041 transcription elongation factor GreA; PFAM: Transcription elongation factor, GreA/GreB, N-terminal; Transcription elongation factor, GreA/GreB, C-terminal; SPTR: uncharacterized protein; IMG reference gene:2503956884; PFAM: domain; Transcription elongation factor, GreA/GreB, C-term; TIGRFAM: transcription elongation factor GreA YP_004411216.1 COGs: COG0036 Pentose-5-phosphate-3-epimerase; InterPro IPR000056; KEGG: tde:TDE2597 ribulose-phosphate 3-epimerase; PFAM: Ribulose-phosphate 3-epimerase; PRIAM: Ribulose-phosphate 3-epimerase; SPTR: Ribulose-phosphate 3-epimerase; TIGRFAM: Ribulose-phosphate 3-epimerase; IMG reference gene:2503956885; PFAM: Ribulose-phosphate 3 epimerase; TIGRFAM: ribulose-phosphate 3-epimerase YP_004411217.1 COGs: COG1490 D-Tyr-tRNAtyr deacylase; HAMAP: D-tyrosyl-tRNA(Tyr) deacylase; InterPro IPR003732; KEGG: trq:TRQ2_0197 D-tyrosyl-tRNA(Tyr) deacylase; PFAM: D-tyrosyl-tRNA(Tyr) deacylase; SPTR: D-tyrosyl-tRNA(Tyr) deacylase; TIGRFAM: D-tyrosyl-tRNA(Tyr) deacylase; IMG reference gene:2503956886; PFAM: D-Tyr-tRNA(Tyr) deacylase; TIGRFAM: D-tyrosyl-tRNA(Tyr) deacylase YP_004411218.1 COGs: COG0468 RecA/RadA recombinase; HAMAP: DNA recombination and repair protein RecA; InterPro IPR013765:IPR003593; KEGG: tde:TDE0872 recombinase A; PFAM: DNA recombination and repair protein RecA; SMART: ATPase, AAA+ type, core; SPTR: Protein recA; TIGRFAM: DNA recombination and repair protein RecA; IMG reference gene:2503956887; PFAM: recA bacterial DNA recombination protein; TIGRFAM: protein RecA YP_004411219.1 COGs: COG1354 conserved hypothetical protein; InterPro IPR003768; KEGG: ssm:Spirs_2052 chromosome segregation and condensation protein ScpA; PFAM: Prokaryotic chromosome segregation/condensation protein ScpA; SPTR: uncharacterized protein; IMG reference gene:2503956888; PFAM: ScpA/B protein YP_004411220.1 COGs: COG1386 transcriptional regulator protein containing the HTH domain; InterPro IPR005234; KEGG: ssm:Spirs_2053 chromosome segregation and condensation protein, ScpB; PFAM: Chromosome segregation/condensation protein ScpB, prokaryote; SPTR: Transcriptional regulator, ; TIGRFAM: Chromosome segregation/condensation protein ScpB, prokaryote; IMG reference gene:2503956889; PFAM: transcriptional regulators (Ypuh-like); TIGRFAM: segregation and condensation protein B YP_004411221.1 COGs: COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthase; InterPro IPR002942:IPR006145:IPR000748; KEGG: ssm:Spirs_2054 RNA-binding S4 domain protein; PFAM: RNA-binding S4; Pseudouridine synthase, RsuA and RluB/C/D/E/F; SMART: RNA-binding S4; SPTR: Pseudouridine synthase; TIGRFAM: Pseudouridine synthase, RsuA/RluB/E/F; IMG reference gene:2503956890; PFAM: RNA pseudouridylate synthase; S4 domain; TIGRFAM: pseudouridine synthase YP_004411222.1 COGs: COG0283 Cytidylate kinase; HAMAP: Cytidylate kinase; InterPro IPR003136:IPR011994; KEGG: ssm:Spirs_2055 cytidylate kinase; PFAM: Cytidylate kinase domain; SPTR: Cytidylate kinase; TIGRFAM: Cytidylate kinase; IMG reference gene:2503956891; PFAM: Cytidylate kinase; TIGRFAM: cytidylate kinase YP_004411223.1 COGs: COG0539 Ribosomal protein S1; InterPro IPR003029:IPR022967; KEGG: ssm:Spirs_2056 ribosomal protein S1; PFAM: Ribosomal protein S1, RNA-binding domain; SMART: RNA-binding domain, S1; SPTR: Cytidylate kinase/ribosomal protein S1; IMG reference gene:2503956892; PFAM: S1 RNA binding domain; TIGRFAM: ribosomal protein S1 YP_004411224.1 InterPro IPR013105; KEGG: sta:STHERM_c10950 hypothetical protein; PFAM: Tetratricopeptide TPR2; SPTR: uncharacterized protein; IMG reference gene:2503956893 YP_004411225.1 KEGG: tgu:100222319 similar to von Willebrand factor; SPTR: ATP-dependent zinc metalloprotease FtsH homolog; IMG reference gene:2503956894 YP_004411226.1 COGs: COG3956 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain; InterPro IPR004518:IPR011551; KEGG: ssm:Spirs_2069 MazG family protein; PFAM: NTP pyrophosphohydrolase MazG, catalytic core; SPTR: uncharacterized protein; TIGRFAM: NTP pyrophosphohydrolase MazG, bacterial; IMG reference gene:2503956895; PFAM: MazG nucleotide pyrophosphohydrolase domain; TIGRFAM: MazG family protein YP_004411227.1 COGs: COG1579 Zn-ribbon protein possibly nucleic acid-binding; InterPro IPR003743; KEGG: ssm:Spirs_2077 protein of unknown function DUF164; PFAM: Protein of unknown function DUF164; SPTR: nucleic acid-binding Zn-ribbon protein; IMG reference gene:2503956897; PFAM: zinc ribbon domain YP_004411228.1 COGs: COG0568 DNA-directed RNA polymerase sigma subunit (sigma70/sigma32); InterProIPR009042:IPR007627:IPR007624:IPR007630:IPR 014284:IPR012760; KEGG: ssm:Spirs_2078 RNA polymerase, sigma 70 subunit, RpoD subfamily; PFAM: RNA polymerase sigma-70 region 3; RNA polymerase sigma-70 region 2; RNA polymerase sigma-70 region 1.2; RNA polymerase sigma-70 region 4; SPTR: RNA polymerase sigma factor; TIGRFAM: RNA polymerase sigma factor RpoD, C-terminal; RNA polymerase sigma-70; IMG reference gene:2503956898; PFAM: Sigma-70, region 4; Sigma-70 region 3; Sigma-70 region 2; Sigma-70 factor, region 1.2; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; RNA polymerase sigma factor RpoD, C-terminal domain YP_004411229.1 COGs: COG0358 DNA primase; InterPro IPR002694:IPR013264:IPR006171:IPR006295; KEGG: ssm:Spirs_2079 DNA primase; PFAM: DNA primase, catalytic core, N-terminal; Zinc finger, CHC2-type; Toprim domain; SPTR: DNA primase; TIGRFAM: DNA primase, DnaG; IMG reference gene:2503956899; PFAM: Toprim domain; DNA primase catalytic core, N-terminal domain; CHC2 zinc finger; DnaB-helicase binding domain of primase; TIGRFAM: DNA primase, catalytic core YP_004411230.1 InterPro IPR005358; KEGG: sta:STHERM_c10760 hypothetical protein; PFAM: Uncharacterised protein family UPF0153; SPTR: uncharacterized protein; IMG reference gene:2503956900; PFAM: Uncharacterised protein family (UPF0153) YP_004411231.1 COGs: COG2309 Leucyl aminopeptidase (aminopeptidase T); InterPro IPR000787; KEGG: lsp:Bsph_0293 aminopeptidase AmpS; PFAM: Peptidase M29, aminopeptidase II; SPTR: Aminopeptidase ampS; IMG reference gene:2503956902; PFAM: Thermophilic metalloprotease (M29) YP_004411232.1 COGs: COG2309 Leucyl aminopeptidase (aminopeptidase T); InterPro IPR000787; KEGG: baf:BAPKO_0070 aminopeptidase II; PFAM: Peptidase M29, aminopeptidase II; SPTR: Aminopeptidase II; IMG reference gene:2503956903; PFAM: Thermophilic metalloprotease (M29) YP_004411233.1 COGs: COG1521 transcriptional regulator protein; HAMAP: Type III pantothenate kinase; InterPro IPR004619; KEGG: afn:Acfer_1593 transcriptional activator, Baf family; PFAM: Type III pantothenate kinase; PRIAM: Pantothenate kinase; SPTR: Type III pantothenate kinase; TIGRFAM: Type III pantothenate kinase; IMG reference gene:2503956904; PFAM: Bordetella pertussis Bvg accessory factor family; TIGRFAM: pantothenate kinase, type III YP_004411234.1 COGs: COG0488 ATPase components of ABC transporter with duplicated ATPase domains; InterPro IPR003439:IPR003593; KEGG: ssm:Spirs_1718 ABC transporter related protein; PFAM: ABC transporter-like; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter related protein; IMG reference gene:2503956905; PFAM: ABC transporter YP_004411235.1 COGs: COG0503 Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein; HAMAP: Adenine phosphoribosyl transferase; InterPro IPR000836:IPR005764; KEGG: tde:TDE1684 adenine phosphoribosyltransferase; PFAM: Phosphoribosyltransferase; SPTR: Adenine phosphoribosyltransferase; TIGRFAM: Adenine phosphoribosyl transferase; IMG reference gene:2503956908; PFAM: Phosphoribosyl transferase domain; TIGRFAM: adenine phosphoribosyltransferase YP_004411236.1 COGs: COG0533 Metal-dependent protease with possible chaperone activity; HAMAP: Peptidase M22, O-sialoglycoprotein peptidase; InterPro IPR000905:IPR022450:IPR017861; KEGG: ssm:Spirs_1796 metalloendopeptidase, glycoprotease; PFAM: Peptidase M22, glycoprotease; PRIAM: O-sialoglycoprotein endopeptidase; SPTR: Probable O-sialoglycoprotein endopeptidase; TIGRFAM: Peptidase M22, O-sialoglycoprotein peptidase; Peptidase M22, glycoprotease, subgroup; IMG reference gene:2503956909; PFAM: Glycoprotease; TIGRFAM: glycoprotease GCP; metallohydrolase, glycoprotease/Kae1 family YP_004411237.1 IMG reference gene:2503956910 YP_004411238.1 COGs: COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase; InterPro IPR002192:IPR008279:IPR000121:IPR010121; KEGG: rmr:Rmar_0942 pyruvate, phosphate dikinase; PFAM: Pyruvate phosphate dikinase, PEP/pyruvate-binding; PEP-utilising enzyme, mobile domain; PEP-utilising enzyme; PRIAM: Pyruvate, phosphate dikinase; SPTR: Pyruvate, phosphate dikinase; TIGRFAM: Pyruvate, phosphate dikinase; IMG reference gene:2503956912; PFAM: PEP-utilising enzyme, TIM barrel domain; PEP-utilising enzyme, mobile domain; Pyruvate phosphate dikinase, PEP/pyruvate binding domain; TIGRFAM: pyruvate, phosphate dikinase YP_004411239.1 COGs: COG0568 DNA-directed RNA polymerase sigma subunit (sigma70/sigma32); InterProIPR009042:IPR007627:IPR007624:IPR007630:IPR 014284; KEGG: ssm:Spirs_1715 RNA polymerase, sigma 70 subunit, RpoD subfamily; PFAM: RNA polymerase sigma-70 region 4; RNA polymerase sigma-70 region 2; RNA polymerase sigma-70 region 1.2; RNA polymerase sigma-70 region 3; SPTR: RNA polymerase sigma-70 factor family protein; TIGRFAM: RNA polymerase sigma-70; IMG reference gene:2503956913; PFAM: Sigma-70, region 4; Sigma-70 region 3; Sigma-70 region 2; Sigma-70 factor, region 1.2; TIGRFAM: RNA polymerase sigma factor, sigma-70 family YP_004411240.1 KEGG: ncr:NCU05178 hypothetical protein; SPTR: 3-deoxy-D-manno-octulosonic-acid transferase; IMG reference gene:2503956914 YP_004411241.1 COGs: COG0234 Co-chaperonin GroES (HSP10); HAMAP: Chaperonin Cpn10; InterPro IPR020818; KEGG: sta:STHERM_c05480 hypothetical protein; PFAM: Chaperonin Cpn10; SMART: Chaperonin Cpn10; SPTR: uncharacterized protein; IMG reference gene:2503956915; PFAM: Chaperonin 10 Kd subunit YP_004411242.1 COGs: COG1199 Rad3-related DNA helicase; InterPro IPR006555; KEGG: ssm:Spirs_1712 helicase C2; SMART: Helicase, ATP-dependent, c2 type; SPTR: uncharacterized protein; IMG reference gene:2503956916 YP_004411243.1 COGs: COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains; InterPro IPR001789:IPR002078:IPR002197:IPR003593; KEGG: ssm:Spirs_1709 two component, sigma54 specific, transcriptional regulator, fis family; PFAM: RNA polymerase sigma factor 54, interaction; Signal transduction response regulator, receiver domain; Helix-turn-helix, Fis-type; SMART: Signal transduction response regulator, receiver domain; ATPase, AAA+ type, core; SPTR: Transcriptional regulatory protein; IMG reference gene:2503956917; PFAM: Response regulator receiver domain; Bacterial regulatory protein, Fis family; Sigma-54 interaction domain YP_004411244.1 COGs: COG0642 Signal transduction histidine kinase; InterPro IPR003661:IPR003594; KEGG: ssm:Spirs_1708 PAS/PAC sensor signal transduction histidine kinase; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; SMART: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; SPTR: sensory transduction histidine kinase; IMG reference gene:2503956918; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain YP_004411245.1 COGs: COG2812 DNA polymerase III gamma/tau subunits; KEGG: ssm:Spirs_1707 DNA polymerase III gamma/tau subunits; SPTR: DNA polymerase III domain protein; IMG reference gene:2503956919 YP_004411246.1 KEGG: ppy:PPE_00816 adenine specific DNA methylase Mod; SPTR: uncharacterized protein; IMG reference gene:2503956920 YP_004411247.1 InterPro IPR003825; KEGG: tde:TDE1973 CvpA family protein; PFAM: Colicin V production, CvpA; SPTR: CvpA family protein; IMG reference gene:2503956921; PFAM: Colicin V production protein YP_004411248.1 COGs: COG0707 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase; HAMAP: N-acetylglucosaminyltransferase, MurG; InterPro IPR004276:IPR007235:IPR006009; KEGG: sta:STHERM_c05390 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide)pyrophosphory l-undecaprenol N-acetylglucosamine transferase; PFAM: Glycosyl transferase, family 28; Glycosyl transferase, family 28, C-terminal; PRIAM: Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; SPTR: UDP-N-acetylglucosamine--N-acetylmuramyl- (Pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; TIGRFAM: N-acetylglucosaminyltransferase, MurG; IMG reference gene:2503956922; PFAM: Glycosyltransferase 28 N-terminal domain; Glycosyltransferase 28 C-terminal domain; TIGRFAM: undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase YP_004411249.1 COGs: COG0653 Preprotein translocase subunit SecA (ATPase RNA helicase); HAMAP: SecA protein; InterProIPR011115:IPR011130:IPR011116:IPR004027:IPR 000185; KEGG: ssm:Spirs_2625 preprotein translocase, SecA subunit; PFAM: SecA DEAD-like, N-terminal; SecA preprotein, cross-linking domain; SecA Wing/Scaffold; SEC-C motif; SMART: SecA DEAD-like, N-terminal; SecA preprotein, cross-linking domain; SPTR: Protein translocase subunit SecA; TIGRFAM: SecA protein; IMG reference gene:2503956923; PFAM: SecA DEAD-like domain; SecA preprotein cross-linking domain; SEC-C motif; SecA Wing and Scaffold domain; TIGRFAM: preprotein translocase, SecA subunit YP_004411250.1 COGs: COG0739 Membrane protein related to metalloendopeptidase; InterPro IPR018392:IPR016047:IPR002482; KEGG: bpo:BP951000_1905 LysM domain/M23/M37 peptidase domain-containing protein; PFAM: Peptidase M23; Peptidoglycan-binding lysin domain; SMART: Peptidoglycan-binding Lysin subgroup; SPTR: LysM domain/M23/M37 peptidase domain protein; IMG reference gene:2503956924; PFAM: Peptidase M23; LysM domain YP_004411251.1 COGs: COG0768 Cell division protein FtsI/penicillin-binding protein 2; InterPro IPR001460; KEGG: ssm:Spirs_2628 peptidoglycan glycosyltransferase; PFAM: Penicillin-binding protein, transpeptidase; PRIAM: Peptidoglycan glycosyltransferase; SPTR: Penicillin-binding protein; IMG reference gene:2503956925; PFAM: Penicillin binding protein transpeptidase domain; Penicillin-binding Protein dimerisation domain YP_004411252.1 COGs: COG1419 Flagellar GTP-binding protein; InterPro IPR000897:IPR003593; KEGG: ssm:Spirs_1583 flagellar biosynthetic protein FlhF; PFAM: Signal recognition particle, SRP54 subunit, GTPase; SMART: Signal recognition particle, SRP54 subunit, GTPase; ATPase, AAA+ type, core; SPTR: Flagellar-associated GTP-binding protein; IMG reference gene:2503956926; PFAM: SRP54-type protein, GTPase domain YP_004411253.1 COGs: COG1220 ATP-dependent protease HslVU (ClpYQ) ATPase subunit; InterPro IPR013093:IPR003593:IPR004491; KEGG: tde:TDE1211 ATP-dependent protease ATP-binding subunit HslU; PFAM: ATPase, AAA-2; SMART: ATPase, AAA+ type, core; SPTR: ATP-dependent protease ATPase subunit HslU; TIGRFAM: Heat shock protein HslU; IMG reference gene:2503956927; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; AAA domain (dynein-related subfamily); TIGRFAM: ATP-dependent protease HslVU, ATPase subunit YP_004411254.1 COGs: COG5405 ATP-dependent protease HslVU (ClpYQ) peptidase subunit; HAMAP: ATP-dependent protease, HslV subunit; InterPro IPR001353:IPR022281; KEGG: sta:STHERM_c09050 ATP-dependent protease HslV; PFAM: Proteasome, subunit alpha/beta; SPTR: ATP-dependent protease HslV; TIGRFAM: ATP-dependent protease, HslV subunit; IMG reference gene:2503956928; PFAM: Proteasome subunit; TIGRFAM: ATP-dependent protease HslVU, peptidase subunit YP_004411255.1 COGs: COG4974 Site-specific recombinase XerD; HAMAP: Tyrosine recombinase xerC; InterPro IPR004107:IPR002104; KEGG: toc:Toce_1087 tyrosine recombinase XerC; PFAM: Integrase, catalytic core, phage; Integrase, N-terminal SAM-like, phage; SPTR: Tyrosine recombinase XerC; IMG reference gene:2503956929; PFAM: Phage integrase, N-terminal SAM-like domain; Phage integrase YP_004411256.1 COGs: COG0758 Rossmann fold nucleotide-binding protein involved in DNA uptake; KEGG: sta:STHERM_c09020 DNA processing protein DprA; SPTR: Smf protein; IMG reference gene:2503956930; PFAM: DNA recombination-mediator protein A YP_004411257.1 COGs: COG4974 Site-specific recombinase XerD; HAMAP: Tyrosine recombinase xerC; InterPro IPR004107:IPR002104; KEGG: ssm:Spirs_1553 tyrosine recombinase XerD; PFAM: Integrase, catalytic core, phage; Integrase, N-terminal SAM-like, phage; SPTR: DNA integration/recombination/invertion protein; IMG reference gene:2503956931; PFAM: Phage integrase, N-terminal SAM-like domain; Phage integrase YP_004411258.1 COGs: COG0206 Cell division GTPase; InterPro IPR003008:IPR018316:IPR000158; KEGG: ssm:Spirs_1552 cell division protein FtsZ; PFAM: Tubulin/FtsZ, GTPase domain; Tubulin/FtsZ, 2-layer sandwich domain; SMART: Tubulin/FtsZ, GTPase domain; Tubulin/FtsZ, 2-layer sandwich domain; SPTR: Cell division protein FtsZ; TIGRFAM: Cell division protein FtsZ, N-terminal; IMG reference gene:2503956932; PFAM: Tubulin/FtsZ family, GTPase domain; FtsZ family, C-terminal domain; TIGRFAM: cell division protein FtsZ YP_004411259.1 COGs: COG0849 Actin-like ATPase involved in cell division; InterPro IPR003494:IPR020823; KEGG: ssm:Spirs_1551 cell division protein FtsA; PFAM: Cell division protein FtsA domain; SMART: Cell division protein FtsA domain; SPTR: Cell division protein FtsA; TIGRFAM: Cell division protein family FtsA; IMG reference gene:2503956933; PFAM: Cell division protein FtsA; TIGRFAM: cell division protein FtsA YP_004411260.1 InterPro IPR013685; KEGG: dma:DMR_33240 cell division protein FtsQ; PFAM: Polypeptide-transport-associated, FtsQ-type; SPTR: cell division protein FtsQ; IMG reference gene:2503956934; PFAM: POTRA domain, FtsQ-type YP_004411261.1 COGs: COG0772 Bacterial cell division membrane protein; InterPro IPR001182; KEGG: sta:STHERM_c08960 hypothetical protein; PFAM: Cell cycle protein; SPTR: uncharacterized protein; IMG reference gene:2503956935; PFAM: Cell cycle protein YP_004411262.1 COGs: COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase; HAMAP: Phospho-N-acetylmuramoyl-pentapeptide transferase; InterPro IPR018480:IPR000715:IPR003524; KEGG: ssm:Spirs_1548 phospho-N-acetylmuramoyl-pentapeptide-transferas E; PFAM: Glycosyl transferase, family 4; Phospho-N-acetylmuramoyl-pentapeptide transferase, conserved site; SPTR:Phospho-N-acetylmuramoyl-pentapeptide-transfer ase; IMG reference gene:2503956936; PFAM: Glycosyl transferase 4; TIGRFAM: phospho-N-acetylmuramoyl-pentapeptide-transferase YP_004411263.1 COGs: COG0770 UDP-N-acetylmuramyl pentapeptide synthase; InterPro IPR000713:IPR013221:IPR005863; KEGG: ssm:Spirs_1547 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diamin opimelate/D-alanyl-D-alanylligase; PFAM: Mur ligase, central; Mur ligase, N-terminal; PRIAM:UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-a lanineligase; SPTR:UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-al anineligase; TIGRFAM: UDP-MurNAc-pentapeptide synthetase; IMG reference gene:2503956937; PFAM: Mur ligase, glutamate ligase domain; Mur ligase, catalytic domain; Mur ligase middle domain; TIGRFAM: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase YP_004411264.1 KEGG: cdi:DIP2252 integral membrane protein; SPTR: conserved integral membrane protein; IMG reference gene:2503956938; TIGRFAM: cell division protein FtsL YP_004411265.1 COGs: COG0275 S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis; HAMAP: S-adenosyl-L-methionine-dependent methyltransferase, MraW; InterPro IPR002903; KEGG: tde:TDE1198 S-adenosyl-methyltransferase MraW; PFAM: S-adenosyl-L-methionine-dependent methyltransferase, MraW; SPTR: Ribosomal RNA small subunit methyltransferase H; TIGRFAM: S-adenosyl-L-methionine-dependent methyltransferase, MraW; IMG reference gene:2503956939; PFAM: MraW methylase; TIGRFAM: S-adenosyl-methyltransferase MraW YP_004411266.1 COGs: COG2001 conserved hypothetical protein; HAMAP: MraZ; InterPro IPR020603:IPR003444; KEGG: ssm:Spirs_1544 MraZ protein; PFAM: MraZ domain; SPTR: Protein MraZ; TIGRFAM: MraZ; IMG reference gene:2503956940; PFAM: MraZ protein; TIGRFAM: mraZ protein YP_004411267.1 COGs: COG1543 conserved hypothetical protein; InterPro IPR004300:IPR015293; KEGG: ssm:Spirs_1542 domain of unknown function DUF1957; PFAM: Domain of unknown function DUF1957; Glycoside hydrolase, family 57, N-terminal; SPTR: uncharacterized protein; IMG reference gene:2503956941; PFAM: Domain of unknown function (DUF1957); Glycosyl hydrolase 57 YP_004411268.1 KEGG: sta:STHERM_c08890 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956942 YP_004411269.1 InterPro IPR004300; KEGG: ssm:Spirs_1540 glycoside hydrolase 57; PFAM: Glycoside hydrolase, family 57, N-terminal; SPTR: Glycoside hydrolase, family 57; IMG reference gene:2503956943; PFAM: Glycosyl hydrolase 57; Domain of unknown function (DUF3536) YP_004411270.1 COGs: COG0497 ATPase involved in DNA repair; InterPro IPR003395:IPR003593:IPR004604; KEGG: sta:STHERM_c08840 DNA repair protein RecN; PFAM: RecF/RecN/SMC; SMART: ATPase, AAA+ type, core; SPTR: DNA repair protein RecN; TIGRFAM: DNA recombination/repair protein RecN; IMG reference gene:2503956944; PFAM: RecF/RecN/SMC N terminal domain; TIGRFAM: DNA repair protein RecN YP_004411271.1 COGs: COG0061 sugar kinase; HAMAP: Inorganic polyphosphate/ATP-NAD kinase, predicted; InterPro IPR002504; KEGG: ssm:Spirs_1534 ATP-NAD/AcoX kinase; PFAM: Inorganic polyphosphate/ATP-NAD kinase, predicted; SPTR: Probable inorganic polyphosphate/ATP-NAD kinase; IMG reference gene:2503956945; PFAM: ATP-NAD kinase YP_004411272.1 COGs: COG0399 pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis; InterPro IPR000653; KEGG: ssm:Spirs_1533 DegT/DnrJ/EryC1/StrS aminotransferase; PFAM: DegT/DnrJ/EryC1/StrS aminotransferase; SPTR: Aminotransferase, DegT/DnrJ/EryC1/StrS family; IMG reference gene:2503956946; PFAM: DegT/DnrJ/EryC1/StrS aminotransferase YP_004411273.1 COGs: COG0450 Peroxiredoxin; InterPro IPR000866:IPR017559; KEGG: lbf:LBF_2905 peroxiredoxin; PFAM: Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant; PRIAM: Peroxiredoxin; SPTR: Peroxiredoxin; TIGRFAM: Peroxiredoxin; IMG reference gene:2503956951; PFAM: C-terminal domain of 1-Cys peroxiredoxin; AhpC/TSA family; TIGRFAM: peroxiredoxin YP_004411274.1 COGs: COG0606 ATPase with chaperone activity; InterPro IPR000523:IPR003593; KEGG: sta:STHERM_c05260 hypothetical protein; PFAM: Magnesium chelatase, ChlI subunit; SMART: ATPase, AAA+ type, core; SPTR: uncharacterized protein; IMG reference gene:2503956952; PFAM: Magnesium chelatase, subunit ChlI; TIGRFAM: Mg chelatase-related protein YP_004411275.1 COGs: COG1175 ABC-type sugar transport systems permease components; InterPro IPR000515; KEGG: ara:Arad_4624 sugar ABC transporter; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Binding-protein-dependent transport system inner membrane component; IMG reference gene:2503956955; PFAM: Binding-protein-dependent transport system inner membrane component YP_004411276.1 COGs: COG0395 ABC-type sugar transport system permease component; InterPro IPR000515; KEGG: kfl:Kfla_2100 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Binding-protein-dependent transport system inner membrane component; IMG reference gene:2503956956; PFAM: Binding-protein-dependent transport system inner membrane component YP_004411277.1 COGs: COG1653 ABC-type sugar transport system periplasmic component; InterPro IPR006059; KEGG: ach:Achl_3128 extracellular solute-binding protein family 1; PFAM: Bacterial extracellular solute-binding, family 1; SPTR: Extracellular solute-binding protein family 1; IMG reference gene:2503956957; PFAM: Bacterial extracellular solute-binding protein YP_004411278.1 KEGG: cpy:Cphy_3399 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956958 YP_004411279.1 COGs: COG3507 Beta-xylosidase; InterPro IPR006710; KEGG: cpy:Cphy_3398 glycoside hydrolase; PFAM: Glycoside hydrolase, family 43; PRIAM: Xylan 1,4-beta-xylosidase; SPTR: Glycoside hydrolase 43; IMG reference gene:2503956959; PFAM: Glycosyl hydrolases family 43 YP_004411280.1 COGs: COG2217 Cation transport ATPase; InterProIPR006121:IPR008250:IPR005834:IPR006404:IPR 006416:IPR001757; KEGG: efa:EF1400 cadmium-translocating P-type ATPase; PFAM: ATPase, P-type, ATPase-associated domain; Heavy metal transport/detoxification protein; Haloacid dehalogenase-like hydrolase; PRIAM: Cadmium-exporting ATPase; SPTR: Cadmium-translocating P-type ATPase; TIGRFAM: ATPase, P-type, heavy metal translocating; ATPase, P-type, heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating; ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter; IMG reference gene:2503956962; PFAM: E1-E2 ATPase; Heavy-metal-associated domain; haloacid dehalogenase-like hydrolase; TIGRFAM: heavy metal translocating P-type ATPase; ATPase, P-type (transporting), HAD superfamily, subfamily IC; heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase YP_004411281.1 COGs: COG0480 Translation elongation factors (GTPase); InterProIPR000795:IPR004161:IPR005517:IPR000640:IPR 005225:IPR004540; KEGG: ssm:Spirs_2534 translation elongation factor G; PFAM: Protein synthesis factor, GTP-binding; Translation elongation factor EFTu/EF1A, domain 2; Translation elongation factor EFG/EF2, domain IV; Translation elongation factor EFG/EF2, C-terminal; SMART: Translation elongation factor EFG/EF2, C-terminal; Translation elongation factor EFG/EF2, domain IV; SPTR: Elongation factor G 1; TIGRFAM: Translation elongation factor EFG/EF2; Small GTP-binding protein; IMG reference gene:2503956963; PFAM: Elongation factor Tu domain 2; Elongation factor G C-terminus; Elongation factor Tu GTP binding domain; Elongation factor G, domain IV; TIGRFAM: translation elongation factor EF-G; small GTP-binding protein domain YP_004411282.1 COGs: COG0480 Translation elongation factors (GTPase); InterPro IPR000795:IPR005517:IPR000640:IPR005225; KEGG: ssm:Spirs_2536 small GTP-binding protein; PFAM: Translation elongation factor EFG/EF2, domain IV; Protein synthesis factor, GTP-binding; Translation elongation factor EFG/EF2, C-terminal; SMART: Translation elongation factor EFG/EF2, domain IV; Translation elongation factor EFG/EF2, C-terminal; SPTR: translation elongation factor G; TIGRFAM: Small GTP-binding protein; IMG reference gene:2503956964; PFAM: Elongation factor G C-terminus; Elongation factor Tu GTP binding domain; Elongation factor G, domain IV; TIGRFAM: translation elongation factor EF-G; small GTP-binding protein domain YP_004411283.1 COGs: COG0220 S-adenosylmethionine-dependent methyltransferase; HAMAP: tRNA (guanine-N-7) methyltransferase; InterPro IPR003358; KEGG: tde:TDE1130 methyltransferase, PFAM: tRNA (guanine-N-7) methyltransferase; SPTR: tRNA (guanine-N(7)-)-methyltransferase; TIGRFAM: tRNA (guanine-N-7) methyltransferase; IMG reference gene:2503956965; PFAM: methyltransferase; TIGRFAM: tRNA (guanine-N(7)-)-methyltransferase YP_004411284.1 COGs: COG1197 Transcription-repair coupling factor (superfamily II helicase); InterProIPR003711:IPR011545:IPR001650:IPR005118:IPR 014001:IPR004576; KEGG: ssm:Spirs_2540 transcription-repair coupling factor; PFAM: DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Transcription factor CarD; Helicase, C-terminal; Transcription-repair-coupling factor domain; SMART: DEAD-like helicase, N-terminal; Helicase, C-terminal; SPTR: Transcription-repair coupling factor; TIGRFAM: Transcription-repair coupling factor; IMG reference gene:2503956966; PFAM: Helicase conserved C-terminal domain; TRCF domain; CarD-like/TRCF domain; DEAD/DEAH box helicase; TIGRFAM: transcription-repair coupling factor (mfd) YP_004411285.1 COGs: COG0483 fructose-1 6-bisphosphatase of inositol monophosphatase; InterPro IPR000760; KEGG: ssm:Spirs_3133 inositol monophosphatase; PFAM: Inositol monophosphatase; SPTR: Inositol monophosphatase; IMG reference gene:2503956967; PFAM: Inositol monophosphatase YP_004411286.1 COGs: COG1738 conserved hypothetical protein; InterPro IPR003744; KEGG: ssm:Spirs_3136 hypothetical protein; PFAM: Protein of unknown function DUF165; SPTR: uncharacterized protein; TIGRFAM: Protein of unknown function DUF165; IMG reference gene:2503956968; PFAM: Uncharacterized ACR, YhhQ family COG1738; TIGRFAM: conserved hypothetical integral membrane protein YP_004411287.1 KEGG: ssm:Spirs_1463 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956969 YP_004411288.1 COGs: COG1327 transcriptional regulator protein consists of a Zn-ribbon and ATP-cone domains; HAMAP: Ribonucleotide reductase regulator NrdR-like; InterPro IPR005144:IPR003796; KEGG: ssm:Spirs_1455 ATP-cone domain protein; PFAM: ATP-cone; SPTR: Transcriptional repressor NrdR; TIGRFAM: Ribonucleotide reductase regulator NrdR-like; IMG reference gene:2503956970; PFAM: ATP cone domain; TIGRFAM: transcriptional regulator NrdR YP_004411289.1 COGs: COG0232 dGTP triphosphohydrolase; InterPro IPR006674:IPR003607; KEGG: ssm:Spirs_1451 metal-dependent phosphohydrolase HD sub domain protein; PFAM: Metal-dependent phosphohydrolase, HD subdomain; SMART: Metal-dependent phosphohydrolase, HD domain; SPTR: Deoxyguanosinetriphosphate triphosphohydrolase-like protein; IMG reference gene:2503956971; PFAM: HD domain; TIGRFAM: deoxyguanosinetriphosphate triphosphohydrolase YP_004411290.1 KEGG: ath:AT3G44920 ATCHX11; monovalent cation:proton antiporter/ sodium:hydrogen antiporter; SPTR: Cation/H(+) antiporter 11; IMG reference gene:2503956972 YP_004411291.1 COGs: COG0703 Shikimate kinase; HAMAP: Shikimate kinase; InterPro IPR000623; KEGG: sta:STHERM_c05910 shikimate kinase; PFAM: Shikimate kinase; SPTR: Shikimate kinase; IMG reference gene:2503956973; PFAM: Shikimate kinase YP_004411292.1 COGs: COG0082 Chorismate synthase; InterPro IPR000453; KEGG: sta:STHERM_c05920 chorismate synthase; PFAM: Chorismate synthase; PRIAM: Chorismate synthase; SPTR: Chorismate synthase; TIGRFAM: Chorismate synthase; IMG reference gene:2503956974; PFAM: Chorismate synthase; TIGRFAM: chorismate synthase YP_004411293.1 COGs: COG1061 DNA or RNA helicase of superfamily II; InterPro IPR006935:IPR001650:IPR014001; KEGG: ssm:Spirs_2851 helicase domain protein; PFAM: Helicase, C-terminal; Restriction endonuclease, type I, R subunit/Type III, Res subunit; SMART: DEAD-like helicase, N-terminal; Helicase, C-terminal; SPTR: Helicase domain protein; IMG reference gene:2503956975; PFAM: Helicase conserved C-terminal domain; Type III restriction enzyme, res subunit YP_004411294.1 KEGG: ssm:Spirs_2852 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956976 YP_004411295.1 COGs: COG0169 Shikimate 5-dehydrogenase; HAMAP: Dehydroquinase class I; Shikimate, quinate/shikimate dehydrogenase; InterProIPR001381:IPR013708:IPR006151:IPR022893:IPR 011342; KEGG: sta:STHERM_c02970 3-dehydroquinate dehydratase, type 1; PFAM: Dehydroquinase class I; Shikimate dehydrogenase substrate binding, N-terminal; Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase; PRIAM: 3-dehydroquinate dehydratase., Shikimate dehydrogenase; SPTR: 3-dehydroquinate dehydratase, type 1; TIGRFAM: Shikimate dehydrogenase; Dehydroquinase class I; IMG reference gene:2503956977; PFAM: Shikimate dehydrogenase substrate binding domain; Type I 3-dehydroquinase; Shikimate / quinate 5-dehydrogenase; TIGRFAM: shikimate 5-dehydrogenase; 3-dehydroquinate dehydratase, type I YP_004411296.1 COGs: COG0488 ATPase components of ABC transporter with duplicated ATPase domains; InterPro IPR003439:IPR003593; KEGG: ssm:Spirs_2861 ABC transporter related protein; PFAM: ABC transporter-like; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter, ATP-binding protein; IMG reference gene:2503956978; PFAM: ABC transporter YP_004411297.1 COGs: COG0424 Nucleotide-binding protein implicated in inhibition of septum formation; HAMAP: Maf-like protein; InterPro IPR003697; KEGG: pth:PTH_0815 nucleotide-binding protein; PFAM: Maf-like protein; SPTR: Maf-like protein COLAER_00364; TIGRFAM: Maf-like protein; IMG reference gene:2503956979; PFAM: Maf-like protein; TIGRFAM: MAF protein YP_004411298.1 COGs: COG0052 Ribosomal protein S2; InterPro IPR001865:IPR005706; KEGG: ssm:Spirs_2864 ribosomal protein S2; PFAM: Ribosomal protein S2; SPTR: 30S ribosomal protein S2; TIGRFAM: Ribosomal protein S2, bacteria/mitochondria/plastid; IMG reference gene:2503956980; PFAM: Ribosomal protein S2; TIGRFAM: ribosomal protein S2, bacterial type YP_004411299.1 COGs: COG0264 Translation elongation factor Ts; HAMAP: Translation elongation factor EFTs/EF1B; InterPro IPR000449:IPR014039:IPR001816; KEGG: ssm:Spirs_2865 translation elongation factor Ts; PFAM: Translation elongation factor EFTs/EF1B, dimerisation; Ubiquitin-associated/translation elongation factor EF1B, N-terminal; SPTR: Elongation factor Ts; TIGRFAM: Translation elongation factor EFTs/EF1B; IMG reference gene:2503956981; PFAM: Elongation factor TS; UBA/TS-N domain; TIGRFAM: translation elongation factor Ts YP_004411300.1 COGs: COG0233 Ribosome recycling factor; HAMAP: Ribosome recycling factor, bacterial-like; InterPro IPR002661:IPR015998; KEGG: ssm:Spirs_2866 ribosome recycling factor; PFAM: Ribosome recycling factor; SPTR: Ribosome-recycling factor; TIGRFAM: Ribosome recycling factor; IMG reference gene:2503956982; PFAM: Ribosome recycling factor; TIGRFAM: ribosome recycling factor YP_004411301.1 COGs: COG0020 Undecaprenyl pyrophosphate synthase; HAMAP:Di-trans-poly-cis-decaprenylcistransferase-li ke; InterPro IPR001441; KEGG: sta:STHERM_c13090 undecaprenyl pyrophosphate synthetase; PFAM:Di-trans-poly-cis-decaprenylcistransferase-lik e; PRIAM: Di-trans,poly-cis-decaprenylcistransferase; SPTR: Undecaprenyl pyrophosphate synthetase; TIGRFAM:Di-trans-poly-cis-decaprenylcistransferase- like; IMG reference gene:2503956983; PFAM: undecaprenyl diphosphate synthase; TIGRFAM: undecaprenyl diphosphate synthase YP_004411302.1 COGs: COG4589 CDP-diglyceride synthetase/phosphatidate cytidylyltransferase; InterPro IPR000374; KEGG: tde:TDE2343 phosphatidate cytidylyltransferase; PFAM: Phosphatidate cytidylyltransferase; SPTR: Phosphatidate cytidylyltransferase; IMG reference gene:2503956984; PFAM: Cytidylyltransferase YP_004411303.1 COGs: COG0743 1-deoxy-D-xylulose 5-phosphate reductoisomerase; HAMAP: 1-deoxy-D-xylulose 5-phosphate reductoisomerase; InterPro IPR013512:IPR013644:IPR003821; KEGG: sta:STHERM_c13110 1-deoxy-D-xylulose 5-phosphate reductoisomerase; PFAM: 1-deoxy-D-xylulose 5-phosphate reductoisomerase, C-terminal; 1-deoxy-D-xylulose 5-phosphate reductoisomerase, N-terminal; PRIAM: 1-deoxy-D-xylulose-5-phosphate reductoisomerase; SPTR: 1-deoxy-D-xylulose 5-phosphate reductoisomerase; TIGRFAM: 1-deoxy-D-xylulose 5-phosphate reductoisomerase; IMG reference gene:2503956985; PFAM: 1-deoxy-D-xylulose 5-phosphate reductoisomerase; 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; TIGRFAM: 1-deoxy-D-xylulose 5-phosphate reductoisomerase YP_004411304.1 COGs: COG0750 membrane-associated Zn-dependent protease 1; InterPro IPR008915; KEGG: ssm:Spirs_2870 membrane-associated zinc metalloprotease; PFAM: Peptidase M50; SPTR: uncharacterized protein; IMG reference gene:2503956986; PFAM: Peptidase M50; TIGRFAM: RIP metalloprotease RseP YP_004411305.1 COGs: COG0305 Replicative DNA helicase; InterPro IPR007693:IPR007694:IPR003593:IPR007692; KEGG: ssm:Spirs_2874 replicative DNA helicase; PFAM: DNA helicase, DnaB-like, C-terminal; DNA helicase, DnaB-like, N-terminal; SMART: ATPase, AAA+ type, core; SPTR: uncharacterized protein; TIGRFAM: DNA helicase, DnaB type; IMG reference gene:2503956987; PFAM: DnaB-like helicase N terminal domain; DnaB-like helicase C terminal domain; TIGRFAM: replicative DNA helicase YP_004411306.1 COGs: COG0359 Ribosomal protein L9; HAMAP: Ribosomal protein L9, bacteria/chloroplast; InterPro IPR020070:IPR020069:IPR020594; KEGG: ssm:Spirs_2875 ribosomal protein L9; PFAM: Ribosomal protein L9, N-terminal; Ribosomal protein L9, C-terminal; SPTR: 50S ribosomal protein L9; TIGRFAM: Ribosomal protein L9, bacteria/chloroplast; IMG reference gene:2503956988; PFAM: Ribosomal protein L9, N-terminal domain; Ribosomal protein L9, C-terminal domain; TIGRFAM: ribosomal protein L9 YP_004411307.1 KEGG: sta:STHERM_c13160 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956989 YP_004411308.1 COGs: COG0238 Ribosomal protein S18; HAMAP: Ribosomal protein S18; InterPro IPR001648; KEGG: ssm:Spirs_2877 ribosomal protein S18; PFAM: Ribosomal protein S18; SPTR: 30S ribosomal protein S18; TIGRFAM: Ribosomal protein S18; IMG reference gene:2503956990; PFAM: Ribosomal protein S18; TIGRFAM: ribosomal protein S18 YP_004411309.1 COGs: COG0629 Single-stranded DNA-binding protein; InterPro IPR000424:IPR011344; KEGG: ssm:Spirs_2878 single-strand binding protein; PFAM: Primosome PriB/single-strand DNA-binding; SPTR: Single-stranded DNA-binding protein; TIGRFAM: Single-strand DNA-binding; IMG reference gene:2503956991; PFAM: Single-strand binding protein family; TIGRFAM: single stranded DNA-binding protein (ssb) YP_004411310.1 COGs: COG0360 Ribosomal protein S6; HAMAP: Ribosomal protein S6, plastid/chloroplast; InterPro IPR000529:IPR020814; KEGG: ssm:Spirs_2879 ribosomal protein S6; PFAM: Ribosomal protein S6; SPTR: 30S ribosomal protein S6; TIGRFAM: Ribosomal protein S6; IMG reference gene:2503956992; PFAM: Ribosomal protein S6; TIGRFAM: ribosomal protein S6 YP_004411311.1 COGs: COG0771 UDP-N-acetylmuramoylalanine-D-glutamate ligase; InterPro IPR013221:IPR004101:IPR005762; KEGG: sta:STHERM_c03310 UDP-N-acetylmuramoylalanine--D-glutamate ligase; PFAM: Mur ligase, central; Mur ligase, C-terminal; PRIAM: UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase; SPTR: UDP-N-acetylmuramoylalanine--D-glutamate ligase; TIGRFAM: UDP-N-acetylmuramoylalanine-D-glutamate ligase; manually curated; IMG reference gene:2503956993; PFAM: Mur ligase middle domain YP_004411312.1 COGs: COG2348 Uncharacterized protein involved in methicillin resistance; InterPro IPR003447; KEGG: ssm:Spirs_2888 methicillin resistance protein; PFAM: Methicillin resistance protein; SPTR: FemAB family protein; IMG reference gene:2503956994; PFAM: FemAB family YP_004411313.1 COGs: COG0143 Methionyl-tRNA synthetase; HAMAP: Methionyl-tRNA synthetase; InterPro IPR015413:IPR002547:IPR014758; KEGG: ssm:Spirs_2889 methionyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class I (M); tRNA-binding domain; PRIAM: Methionine--tRNA ligase; SPTR: Methionyl-tRNA synthetase; TIGRFAM: Methionyl-tRNA synthetase, class Ia; IMG reference gene:2503956995; PFAM: tRNA synthetases class I (M); Anticodon-binding domain; tRNA binding domain; TIGRFAM: methionyl-tRNA synthetase C-terminal region/beta chain; methionyl-tRNA synthetase YP_004411314.1 COGs: COG0330 Membrane protease subunits stomatin/prohibitin homologs; InterPro IPR001107:IPR010201; KEGG: sta:STHERM_c16310 hypothetical protein; PFAM: Band 7 protein; SMART: Band 7 protein; SPTR: uncharacterized protein; TIGRFAM: HflK; IMG reference gene:2503956996; PFAM: SPFH domain / Band 7 family; TIGRFAM: HflK protein YP_004411315.1 COGs: COG0330 Membrane protease subunits stomatin/prohibitin homologs; InterPro IPR001107:IPR010200; KEGG: ssm:Spirs_2891 HflC protein; PFAM: Band 7 protein; SMART: Band 7 protein; SPTR: HflC protein; TIGRFAM: HflC; IMG reference gene:2503956997; PFAM: SPFH domain / Band 7 family; TIGRFAM: HflC protein YP_004411316.1 KEGG: atu:Atu2463 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503956998 YP_004411317.1 KEGG: clj:CLJU_c23260 hypothetical protein; SPTR: Uncharacterized membrane protein; IMG reference gene:2503956999 YP_004411318.1 COGs: COG1131 ABC-type multidrug transport system ATPase component; InterPro IPR003439:IPR003593; KEGG: kol:Kole_0152 ABC transporter related; PFAM: ABC transporter-like; SMART: ATPase, AAA+ type, core; SPTR: ABC superfamily ATP binding cassette transporter, ABC protein; IMG reference gene:2503957000; PFAM: ABC transporter YP_004411319.1 COGs: COG0137 Argininosuccinate synthase; HAMAP: Argininosuccinate synthase; InterPro IPR001518; KEGG: trq:TRQ2_1045 argininosuccinate synthase; PFAM: Argininosuccinate synthase; PRIAM: Argininosuccinate synthase; SPTR: Argininosuccinate synthase; TIGRFAM: Argininosuccinate synthase; IMG reference gene:2503957001; PFAM: Arginosuccinate synthase; TIGRFAM: argininosuccinate synthase YP_004411320.1 InterPro IPR001845; KEGG: clo:HMPREF0868_0433 transcriptional repressor SmtB family protein; PFAM: HTH transcriptional regulator, ArsR; SMART: HTH transcriptional regulator, ArsR; SPTR: Transcriptional regulator, ArsR family; IMG reference gene:2503957002; PFAM: Bacterial regulatory protein, arsR family YP_004411321.1 COGs: COG3661 Alpha-glucuronidase; InterPro IPR011100:IPR011099; KEGG: rbi:RB2501_04530 alpha-glucuronidase; PFAM: Glycosyl hydrolase 67 middle; Glycosyl hydrolase 67, C-terminal; PRIAM: Alpha-glucuronidase; SPTR: Alpha-glucuronidase; IMG reference gene:2503957003; PFAM: Glycosyl hydrolase 67 C-terminus; Glycosyl hydrolase 67 middle domain; Glycosyl hydrolase 67 N-terminus YP_004411322.1 COGs: COG1653 ABC-type sugar transport system periplasmic component; KEGG: sta:STHERM_c18860 sugar ABC transporter substrate-binding protein; SPTR: Sugar ABC transporter substrate-binding protein; IMG reference gene:2503957004; PFAM: Bacterial extracellular solute-binding protein YP_004411323.1 COGs: COG0395 ABC-type sugar transport system permease component; InterPro IPR000515; KEGG: sta:STHERM_c18870 transporter; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Transporter; IMG reference gene:2503957005; PFAM: Binding-protein-dependent transport system inner membrane component YP_004411324.1 COGs: COG4209 ABC-type polysaccharide transport system permease component; InterPro IPR000515; KEGG: sta:STHERM_c18880 transporter; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Transporter; IMG reference gene:2503957006; PFAM: Binding-protein-dependent transport system inner membrane component YP_004411325.1 COGs: COG1609 Transcriptional regulators; InterPro IPR000524:IPR001761; KEGG: ttm:Tthe_0670 transcriptional regulator, GntR family with LacI sensor; PFAM: HTH transcriptional regulator, GntR; Periplasmic binding protein/LacI transcriptional regulator; SMART: HTH transcriptional regulator, GntR; SPTR: Transcriptional regulators; IMG reference gene:2503957007; PFAM: Bacterial regulatory proteins, gntR family; family YP_004411326.1 COGs: COG3250 Beta-galactosidase/beta-glucuronidase; InterPro IPR006104:IPR006103; KEGG: pjd:Pjdr2_2523 glycoside hydrolase 2 sugar binding; PFAM: Glycoside hydrolase, family 2, carbohydrate-binding; Glycoside hydrolase, family 2, TIM barrel; PRIAM: Beta-galactosidase; SPTR: Glycoside hydrolase 2 sugar binding; IMG reference gene:2503957008; PFAM: domain; Glycosyl hydrolases family 2, TIM barrel domain; Glycosyl hydrolases family 2, sugar binding domain YP_004411327.1 InterPro IPR001087; KEGG: sli:Slin_3977 lipolytic protein G-D-S-L family; PFAM: Lipase, GDSL; SPTR: acetylhydrolase; IMG reference gene:2503957009; PFAM: GDSL-like Lipase/Acylhydrolase YP_004411328.1 COGs: COG1472 Beta-glucosidase-related glycosidase; InterPro IPR001764:IPR002772; KEGG: cbe:Cbei_4974 glycoside hydrolase 3 protein; PFAM: Glycoside hydrolase, family 3, C-terminal; Glycoside hydrolase, family 3, N-terminal; PRIAM: Beta-glucosidase; SPTR: Glycoside hydrolase, family 3 domain protein; IMG reference gene:2503957010; PFAM: Glycosyl hydrolase 3 C terminal domain; Glycosyl hydrolase 3 N terminal domain YP_004411329.1 COGs: COG0395 ABC-type sugar transport system permease component; InterPro IPR000515; KEGG: pjd:Pjdr2_5596 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Binding-protein-dependent transport system inner membrane component; IMG reference gene:2503957011; PFAM: Binding-protein-dependent transport system inner membrane component YP_004411330.1 COGs: COG1175 ABC-type sugar transport systems permease components; InterPro IPR000515; KEGG: pjd:Pjdr2_5597 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Binding-protein-dependent transport system inner membrane component; IMG reference gene:2503957012; PFAM: Binding-protein-dependent transport system inner membrane component YP_004411331.1 COGs: COG1653 ABC-type sugar transport system periplasmic component; InterPro IPR006059; KEGG: pjd:Pjdr2_5598 extracellular solute-binding protein family 1; PFAM: Bacterial extracellular solute-binding, family 1; SPTR: bacterial extracellular solute-binding protein; IMG reference gene:2503957013 YP_004411332.1 InterPro IPR000852; KEGG: ttm:Tthe_0982 xylan 1,4-beta-xylosidase; PFAM: Glycoside hydrolase, family 52; PRIAM: Xylan 1,4-beta-xylosidase; SPTR: Xylan 1,4-beta-xylosidase; IMG reference gene:2503957014; PFAM: Glycosyl hydrolase 52 YP_004411333.1 COGs: COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; InterPro IPR001789:IPR000792; KEGG: ote:Oter_0043 two component LuxR family transcriptional regulator; PFAM: Signal transduction response regulator, receiver domain; Transcription regulator LuxR, C-terminal; SMART: Signal transduction response regulator, receiver domain; Transcription regulator LuxR, C-terminal; SPTR: Two component transcriptional regulator, LuxR family; IMG reference gene:2503957015; PFAM: Response regulator receiver domain; Bacterial regulatory proteins, luxR family YP_004411334.1 COGs: COG1609 Transcriptional regulators; InterPro IPR001761:IPR003594; KEGG: ssm:Spirs_1217 ATP-binding region ATPase domain protein; PFAM: ATPase-like, ATP-binding domain; Periplasmic binding protein/LacI transcriptional regulator; SMART: ATPase-like, ATP-binding domain; SPTR: Histidine kinase; IMG reference gene:2503957016; PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; family YP_004411335.1 COGs: COG0563 Adenylate kinase and related kinase; HAMAP: Adenylate kinase; InterPro IPR000850:IPR007862:IPR006259; KEGG: ssm:Spirs_1529 adenylate kinase; PFAM: Adenylate kinase; Adenylate kinase, active site lid domain; SPTR: Adenylate kinase; TIGRFAM: Adenylate kinase, subfamily; IMG reference gene:2503957017; PFAM: Adenylate kinase, active site lid; Adenylate kinase; TIGRFAM: adenylate kinases YP_004411336.1 COGs: COG0035 Uracil phosphoribosyltransferase; KEGG: ssm:Spirs_1527 phosphoribosyl transferase domain-containing protein; SPTR: Phosphoribosyl transferase domain protein; IMG reference gene:2503957018 YP_004411337.1 KEGG: aae:aq_854 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957019 YP_004411338.1 COGs: COG0328 Ribonuclease HI; HAMAP: Ribonuclease H; InterPro IPR002156:IPR022892; KEGG: rce:RC1_3647 ribonuclease H; PFAM: Ribonuclease H domain; PRIAM: Ribonuclease H; SPTR: Ribonuclease H; IMG reference gene:2503957020; PFAM: RNase H YP_004411339.1 COGs: COG0760 Parvulin-like peptidyl-prolyl isomerase; InterPro IPR000297; KEGG: dsh:Dshi_3566 PpiC-type peptidyl-prolyl cis-trans isomerase; PFAM: Peptidyl-prolyl cis-trans isomerase, PpiC-type; SPTR: PpiC-type peptidyl-prolyl cis-trans isomerase; IMG reference gene:2503957021; PFAM: PPIC-type PPIASE domain YP_004411340.1 InterPro IPR008172; KEGG: ssm:Spirs_2340 adenylyl cyclase CyaB; PFAM: Adenylate cyclase; SPTR: uncharacterized protein; IMG reference gene:2503957022; PFAM: CYTH domain YP_004411341.1 KEGG: ssm:Spirs_2341 hypothetical protein; SPTR: membrane protein; IMG reference gene:2503957023 YP_004411342.1 InterPro IPR011701; KEGG: sfu:Sfum_0552 major facilitator transporter; PFAM: Major facilitator superfamily MFS-1; SPTR: Major facilitator superfamily MFS_1; IMG reference gene:2503957024; PFAM: Major Facilitator Superfamily YP_004411343.1 COGs: COG1963 conserved hypothetical protein; InterPro IPR003832; KEGG: msv:Mesil_2435 acid phosphatase/vanadium-dependent haloperoxidase related protein; PFAM: Acid phosphatase/vanadium-dependent haloperoxidase-related; SPTR: Acid phosphatase/vanadium-dependent haloperoxidase related protein; IMG reference gene:2503957025; PFAM: Divergent PAP2 family YP_004411344.1 COGs: COG0834 ABC-type amino acid transport/signal transduction systems periplasmic component/domain; InterPro IPR001638; KEGG: dal:Dalk_1255 extracellular solute-binding protein family 3; PFAM: Extracellular solute-binding protein, family 3; SMART: Extracellular solute-binding protein, family 3; SPTR: Extracellular solute-binding protein family 3; IMG reference gene:2503957026; PFAM: Bacterial extracellular solute-binding proteins, family 3 YP_004411345.1 COGs: COG0834 ABC-type amino acid transport/signal transduction systems periplasmic component/domain; InterPro IPR001638; KEGG: dvl:Dvul_1824 extracellular solute-binding protein; PFAM: Extracellular solute-binding protein, family 3; SMART: Extracellular solute-binding protein, family 3; SPTR: Amino acid ABC transporter, periplasmic amino acid-binding protein; IMG reference gene:2503957027; PFAM: Bacterial extracellular solute-binding proteins, family 3 YP_004411346.1 COGs: COG2826 Transposase and inactivated derivatives IS30 family; InterPro IPR001584; KEGG: ccb:Clocel_0985 integrase catalytic region; PFAM: Integrase, catalytic core; SPTR: Transposase and inactivated derivatives, IS30 family; IMG reference gene:2503957028 YP_004411347.1 COGs: COG0765 ABC-type amino acid transport system permease component; InterPro IPR000515:IPR010065; KEGG: gsu:GSU3405 amino acid ABC transporter, permease; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Amino acid ABC transporter, permease; TIGRFAM: Amino acid ABC transporter, permease, 3-TM domain, His/Glu/Gln/Arg/opine family; IMG reference gene:2503957029; PFAM: Binding-protein-dependent transport system inner membrane component; TIGRFAM: amine acid ABC transporter, permease, 3-TM region, His/Glu/Gln/Arg/opine family YP_004411348.1 COGs: COG1126 ABC-type polar amino acid transport system ATPase component; InterPro IPR003439:IPR003593; KEGG: afu:AF0680 glutamine ABC transporter, ATP-binding protein; PFAM: ABC transporter-like; PRIAM: Phosphonate-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: Glutamine ABC transporter, ATP-binding protein (GlnQ); IMG reference gene:2503957030; PFAM: ABC transporter YP_004411349.1 COGs: COG5421 Transposase; InterPro IPR002559; KEGG: cob:COB47_1677 transposase IS4 family protein; PFAM: Transposase, IS4-like; SPTR: Transposase IS4 family protein; IMG reference gene:2503957031; PFAM: Transposase DDE domain YP_004411350.1 COGs: COG0144 tRNA and rRNA cytosine-C5-methylase; InterPro IPR001678; KEGG: ssm:Spirs_2381 Fmu (Sun) domain protein; PFAM: Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p; SPTR: Fmu (Sun) domain protein; IMG reference gene:2503957033; PFAM: NOL1/NOP2/sun family YP_004411351.1 COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR000212; KEGG: ssm:Spirs_2383 UvrD/REP helicase; PFAM: DNA helicase, UvrD/REP type; SPTR: ATP-dependent DNA helicase PcrA; IMG reference gene:2503957034; PFAM: UvrD/REP helicase YP_004411352.1 KEGG: tgu:100218726 mitogen-activated protein kinase 6; SPTR: Mitogen-activated protein kinase 6; IMG reference gene:2503957035 YP_004411353.1 COGs: COG1192 ATPase involved in chromosome partitioning; InterPro IPR002586; KEGG: bhy:BHWA1_02684 plasmid partition protein; PFAM: Cobyrinic acid a,c-diamide synthase; SPTR: Plasmid partition protein; IMG reference gene:2503957036; PFAM: CobQ/CobB/MinD/ParA nucleotide binding domain YP_004411354.1 COGs: COG2723 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase; InterPro IPR001360:IPR017736; KEGG: mrb:Mrub_0288 beta-galactosidase; PFAM: Glycoside hydrolase, family 1; PRIAM: Beta-glucosidase; SPTR: Beta-galactosidase; TIGRFAM: Glycoside hydrolase, family 1, beta-glucosidase; IMG reference gene:2503957037; PFAM: Glycosyl hydrolase 1; TIGRFAM: beta-galactosidase YP_004411355.1 COGs: COG0708 Exonuclease III; InterPro IPR005135:IPR000097:IPR004808; KEGG: aoe:Clos_2318 exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase; PRIAM: Exodeoxyribonuclease III; SPTR: Exodeoxyribonuclease III Xth; TIGRFAM: Exodeoxyribonuclease III xth; AP endonuclease, family 1; IMG reference gene:2503957038; PFAM: Endonuclease/Exonuclease/phosphatase; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III (xth) YP_004411356.1 COGs: COG1217 membrane GTPase involved in stress response; InterProIPR000795:IPR004161:IPR000640:IPR005225:IPR 006298; KEGG: ssm:Spirs_3901 GTP-binding protein TypA; PFAM: Protein synthesis factor, GTP-binding; Translation elongation factor EFTu/EF1A, domain 2; Translation elongation factor EFG/EF2, C-terminal; SMART: Translation elongation factor EFG/EF2, C-terminal; SPTR: GTP-binding protein TypA; TIGRFAM: GTP-binding protein TypA; Small GTP-binding protein; IMG reference gene:2503957039; PFAM: Elongation factor Tu domain 2; Elongation factor G C-terminus; Elongation factor Tu GTP binding domain; TIGRFAM: GTP-binding protein TypA/BipA; small GTP-binding protein domain YP_004411357.1 InterPro IPR000182; KEGG: ret:RHE_CH01554 acetyltransferase; PFAM: GCN5-related N-acetyltransferase (GNAT) domain; SPTR: acetyltransferase; IMG reference gene:2503957044; PFAM: Acetyltransferase (GNAT) family YP_004411358.1 COGs: COG0596 hydrolase or acyltransferase (alpha/beta hydrolase superfamily); InterPro IPR000073; KEGG: str:Sterm_0308 alpha/beta fold family hydrolase, PFAM: Alpha/beta hydrolase fold-1; SPTR: Alpha/beta hydrolase fold protein; IMG reference gene:2503957045; PFAM: alpha/beta hydrolase fold YP_004411359.1 COGs: COG1236 exonuclease of the beta-lactamase fold involved in RNA processing; InterPro IPR001279:IPR011108; KEGG: cce:Ccel_1759 RNA-metabolising metallo-beta-lactamase; PFAM: Beta-lactamase-like; RNA-metabolising metallo-beta-lactamase; SMART: Beta-lactamase-like; SPTR: uncharacterized protein; IMG reference gene:2503957046; PFAM: Metallo-beta-lactamase superfamily; RNA-metabolising metallo-beta-lactamase; Beta-Casp domain YP_004411360.1 COGs: COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); InterPro IPR002178; KEGG: rba:RB8584 PTS system, fructose-specific enzyme II, BC component; PFAM: Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2; SPTR: PTS system, fructose-specific enzyme II, BC component; IMG reference gene:2503957047; PFAM: Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 YP_004411361.1 InterPro IPR006016; KEGG: ssm:Spirs_3105 UspA domain protein; PFAM: UspA; SPTR: UspA domain protein; IMG reference gene:2503957048; PFAM: Universal stress protein family YP_004411362.1 COGs: COG1394 H+-ATPase subunit D; HAMAP: ATPase, V1/A1 complex, subunit D; InterPro IPR002699; KEGG: ssm:Spirs_3106 V-type ATPase, D subunit; PFAM: ATPase, V1/A1 complex, subunit D; SPTR: V-type ATPase, D subunit; TIGRFAM: ATPase, V1/A1 complex, subunit D; IMG reference gene:2503957049; PFAM: ATP synthase subunit D; TIGRFAM: H(+)-transporting ATP synthase, vacuolar type, subunit D YP_004411363.1 COGs: COG1156 H+-ATPase subunit B; HAMAP: V-type ATP synthase regulatory subunit B/beta; InterPro IPR004100:IPR000194:IPR000793:IPR022879; KEGG: ssm:Spirs_3107 H+transporting two-sector ATPase alpha/beta subunit central region; PFAM: ATPase, alpha/beta subunit, nucleotide-binding domain; ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal; ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal; SPTR: V-type ATP synthase beta chain 2; IMG reference gene:2503957050; PFAM: ATP synthase alpha/beta family, beta-barrel domain; ATP synthase alpha/beta chain, C terminal domain; ATP synthase alpha/beta family, nucleotide-binding domain YP_004411364.1 COGs: COG1155 H+-ATPase subunit A; HAMAP: V-type ATP synthase catalytic subunit A/alpha; InterProIPR004100:IPR000194:IPR000793:IPR022878:IPR 003593; KEGG: ssm:Spirs_3108 sodium-transporting two-sector ATPase; PFAM: ATPase, alpha/beta subunit, nucleotide-binding domain; ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal; ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal; SMART: ATPase, AAA+ type, core; SPTR: V-type ATP synthase alpha chain; IMG reference gene:2503957051; PFAM: ATP synthase alpha/beta family, beta-barrel domain; ATP synthase alpha/beta chain, C terminal domain; ATP synthase alpha/beta family, nucleotide-binding domain YP_004411365.1 InterPro IPR002842; KEGG: ssm:Spirs_3109 H+transporting two-sector ATPase E subunit; PFAM: ATPase, V1/A1 complex, subunit E; SPTR: Vacuolar H+-ATPase E subunit; IMG reference gene:2503957052; PFAM: ATP synthase (E/31 kDa) subunit YP_004411366.1 COGs: COG1436 H+-ATPase subunit F; InterPro IPR008218; KEGG: ssm:Spirs_3110 vacuolar H+transporting two-sector ATPase F subunit; PFAM: ATPase, V1/A1 complex, subunit F; SPTR: A1A0 archaeal ATP synthase subunit F AhaF; IMG reference gene:2503957053; PFAM: ATP synthase (F/14-kDa) subunit YP_004411367.1 InterPro IPR002379; KEGG: ssm:Spirs_3111 H+transporting two-sector ATPase C subunit; PFAM: ATPase, F0/V0 complex, subunit C; SPTR: V-ATPase F-subunit; IMG reference gene:2503957054; PFAM: ATP synthase subunit C YP_004411368.1 COGs: COG1269 H+-ATPase subunit I; InterPro IPR002490; KEGG: ssm:Spirs_3112 V-type ATPase 116 kDa subunit; PFAM: ATPase, V0/A0 complex, 116kDa subunit; SPTR: V-type sodium ATP synthase subunit I; IMG reference gene:2503957055; PFAM: V-type ATPase 116kDa subunit family YP_004411369.1 COGs: COG1527 H+-ATPase subunit C; InterPro IPR002843; KEGG: ssm:Spirs_3113 H+transporting two-sector ATPase C (AC39) subunit; PFAM: ATPase, V0/A0 complex, subunit C/D; SPTR: H(+)-transporting two-sector ATPase; IMG reference gene:2503957056; PFAM: ATP synthase (C/AC39) subunit YP_004411370.1 KEGG: sna:Snas_1610 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957057 YP_004411371.1 COGs: COG0675 Transposase and inactivated derivatives; InterPro IPR001959:IPR010095; KEGG: xfm:Xfasm12_1563 transposase OrfB; PFAM: Transposase, probable, IS891/IS1136/IS1341; Transposase, IS605 OrfB, C-terminal; SPTR: Transposase OrfB; TIGRFAM: Transposase, IS605 OrfB, C-terminal; IMG reference gene:2503957058; PFAM: Helix-turn-helix domain; transposase DNA-binding domain; Probable transposase; TIGRFAM: transposase, IS605 OrfB family, central region YP_004411372.1 COGs: COG2452 site-specific integrase-resolvase; InterPro IPR000551:IPR006119; KEGG: xfm:Xfasm12_1564 hypothetical protein; PFAM: Resolvase, N-terminal; HTH transcriptional regulator, MerR; SMART: Resolvase, N-terminal; SPTR: uncharacterized protein; IMG reference gene:2503957059; PFAM: MerR family regulatory protein; Resolvase, N terminal domain YP_004411373.1 KEGG: bcb:BCB4264_A3629 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957060 YP_004411374.1 COGs: COG2184 Protein involved in cell division; InterPro IPR003812; KEGG: ajs:Ajs_4242 filamentation induced by cAMP protein Fic; PFAM: Filamentation induced by cAMP/death on curing-related; SPTR: Filamentation induced by cAMP protein Fic; IMG reference gene:2503957061; PFAM: Fic/DOC family YP_004411375.1 COGs: COG0366 Glycosidase; InterPro IPR006047:IPR006589; KEGG: csc:Csac_2428 alpha amylase, catalytic region; PFAM: Glycosyl hydrolase, family 13, catalytic domain; PRIAM: Oligo-1,6-glucosidase; SMART: Glycosyl hydrolase, family 13, subfamily, catalytic domain; SPTR: Alpha amylase, catalytic region; IMG reference gene:2503957063; PFAM: Alpha amylase, catalytic domain YP_004411376.1 COGs: COG3345 Alpha-galactosidase; InterPro IPR000111; KEGG: cpy:Cphy_1936 glycoside hydrolase clan GH-D; PFAM: Glycoside hydrolase, clan GH-D; PRIAM: Alpha-galactosidase; SPTR: Glycoside hydrolase clan GH-D; IMG reference gene:2503957064; PFAM: Melibiase YP_004411377.1 COGs: COG2723 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase; InterPro IPR001360; KEGG: cpy:Cphy_1937 glycoside hydrolase; PFAM: Glycoside hydrolase, family 1; PRIAM: Beta-glucosidase; SPTR: Glycoside hydrolase 1; IMG reference gene:2503957065; PFAM: Glycosyl hydrolase 1 YP_004411378.1 COGs: COG2211 Na+/melibiose symporter and related transporter; InterPro IPR011701:IPR001927; KEGG: cpy:Cphy_1935 sugar (glycoside-pentoside-hexuronide) transporter; PFAM: Major facilitator superfamily MFS-1; SPTR: Sugar (Glycoside-Pentoside-Hexuronide) transporter; TIGRFAM: Sodium:galactoside symporter; IMG reference gene:2503957066; TIGRFAM: sugar (Glycoside-Pentoside-Hexuronide) transporter YP_004411379.1 COGs: COG1296 branched-chain amino acid permease (azaleucine resistance); InterPro IPR011606; KEGG: gwc:GWCH70_0661 AzlC family protein; PFAM: Branched-chain amino acid transport, permease; SPTR: AzlC family protein; IMG reference gene:2503957067; PFAM: AzlC protein; TIGRFAM: 4-azaleucine resistance probable transporter AzlC YP_004411380.1 InterPro IPR008407; KEGG: bse:Bsel_1519 branched-chain amino acid transport; PFAM: Branched-chain amino acid transport, AzlD; SPTR: uncharacterized protein; IMG reference gene:2503957068; PFAM: Branched-chain amino acid transport protein (AzlD) YP_004411381.1 KEGG: fbc:FB2170_04545 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957069 YP_004411382.1 KEGG: paa:Paes_0399 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957070 YP_004411383.1 COGs: COG0824 thioesterase; InterPro IPR006683:IPR006684; KEGG: asu:Asuc_1795 Pol-Pal system-associated acyl-CoA thioesterase; PFAM: Thioesterase superfamily; SPTR: Pol-Pal system-associated acyl-CoA thioesterase; TIGRFAM: 4-hydroxybenzoyl-CoA thioesterase; IMG reference gene:2503957071; PFAM: Thioesterase superfamily; TIGRFAM: acyl-CoA thioester hydrolase, YbgC/YbaW family; tol-pal system-associated acyl-CoA thioesterase YP_004411384.1 COGs: COG0019 Diaminopimelate decarboxylase; InterPro IPR022644:IPR022643; KEGG: ssm:Spirs_1460 Orn/DAP/Arg decarboxylase 2; PFAM: Orn/DAP/Arg decarboxylase 2, C-terminal; Orn/DAP/Arg decarboxylase 2, N-terminal; PRIAM: Diaminopimelate decarboxylase; SPTR: Diaminopimelate decarboxylase; IMG reference gene:2503957072; PFAM: Pyridoxal-dependent decarboxylase, C-terminal sheet domain; Pyridoxal-dependent decarboxylase, pyridoxal binding domain; TIGRFAM: diaminopimelate decarboxylase YP_004411385.1 COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; HAMAP: LL-diaminopimelate aminotransferase; InterPro IPR004839:IPR019942; KEGG: ssm:Spirs_1461 LL-diaminopimelate aminotransferase; PFAM: Aminotransferase, class I/classII; PRIAM: LL-diaminopimelate aminotransferase; SPTR: LL-diaminopimelate aminotransferase; TIGRFAM: LL-diaminopimelate aminotransferase, plant-related; IMG reference gene:2503957073; PFAM: Aminotransferase class I and II; TIGRFAM: LL-diaminopimelate aminotransferase YP_004411386.1 COGs: COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; HAMAP: Dihydrodipicolinate synthase; InterPro IPR002220:IPR005263; KEGG: ssm:Spirs_1462 dihydrodipicolinate synthase; PFAM: Dihydrodipicolinate synthetase; SPTR: Dihydrodipicolinate synthase; TIGRFAM: Dihydrodipicolinate synthase subfamily; IMG reference gene:2503957074; PFAM: Dihydrodipicolinate synthetase; TIGRFAM: dihydrodipicolinate synthase YP_004411387.1 COGs: COG0289 Dihydrodipicolinate reductase; HAMAP: Dihydrodipicolinate reductase, bacterial/plant; InterPro IPR000846:IPR022663:IPR011770; KEGG: sta:STHERM_c08680 dihydrodipicolinate reductase; PFAM: Dihydrodipicolinate reductase, N-terminal; Dihydrodipicolinate reductase, C-terminal; PRIAM: Dihydrodipicolinate reductase; SPTR: Dihydrodipicolinate reductase; TIGRFAM: Dihydrodipicolinate reductase, bacterial/plant; IMG reference gene:2503957075; PFAM: Dihydrodipicolinate reductase, N-terminus; Dihydrodipicolinate reductase, C-terminus; TIGRFAM: dihydrodipicolinate reductase YP_004411388.1 COGs: COG0550 Topoisomerase IA; InterProIPR006171:IPR013497:IPR003601:IPR003602:IPR 005738; KEGG: dhd:Dhaf_4786 DNA topoisomerase III; PFAM: DNA topoisomerase, type IA, central; Toprim domain; PRIAM: DNA topoisomerase; SMART: DNA topoisomerase, type IA, DNA-binding; DNA topoisomerase, type IA, domain 2; Toprim domain; SPTR: DNA topoisomerase; TIGRFAM: DNA topoisomerase III, bacterial-type; IMG reference gene:2503957076; PFAM: Toprim domain; DNA topoisomerase; TIGRFAM: DNA topoisomerase III, bacteria and conjugative plasmid YP_004411389.1 InterPro IPR001450; KEGG: fma:FMG_1124 ferredoxin; PFAM: 4Fe-4S binding domain; SPTR: Conserved domain protein; manually curated; IMG reference gene:2503957077; PFAM: 4Fe-4S binding domain YP_004411390.1 COGs: COG1570 Exonuclease VII large subunit; HAMAP: Exonuclease VII, large subunit; InterPro IPR004365:IPR020579:IPR003753; KEGG: ssm:Spirs_1343 exodeoxyribonuclease VII, large subunit; PFAM: Exonuclease VII, large subunit, C-terminal; Nucleic acid binding, OB-fold, tRNA/helicase-type; PRIAM: Exodeoxyribonuclease VII; SPTR: Exodeoxyribonuclease 7 large subunit; TIGRFAM: Exonuclease VII, large subunit; IMG reference gene:2503957078; PFAM: Exonuclease VII, large subunit; OB-fold nucleic acid binding domain; TIGRFAM: exodeoxyribonuclease VII, large subunit YP_004411391.1 HAMAP: Exonuclease VII, small subunit; InterPro IPR003761; KEGG: sta:STHERM_c09580 hypothetical protein; PFAM: Exonuclease VII, small subunit; SPTR: uncharacterized protein; IMG reference gene:2503957079; PFAM: Exonuclease VII small subunit; TIGRFAM: exodeoxyribonuclease VII, small subunit YP_004411392.1 COGs: COG4977 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain; InterPro IPR002818; KEGG: clj:CLJU_c17590 intracellular protease/amidase related enzyme,ThiJ family; PFAM: ThiJ/PfpI; SPTR: DJ-1/PfpI family protein; IMG reference gene:2503957080; PFAM: DJ-1/PfpI family YP_004411393.1 COGs: COG2309 Leucyl aminopeptidase (aminopeptidase T); KEGG: ssm:Spirs_1009 peptidase M29 aminopeptidase II; SPTR: Peptidase M29 aminopeptidase II; IMG reference gene:2503957081; PFAM: Thermophilic metalloprotease (M29) YP_004411394.1 COGs: COG0564 Pseudouridylate synthase 23S RNA-specific; InterPro IPR006145; KEGG: tde:TDE1083 RNA pseudouridylate synthase; PFAM: Pseudouridine synthase, RsuA and RluB/C/D/E/F; SPTR: Pseudouridine synthase; IMG reference gene:2503957082; PFAM: RNA pseudouridylate synthase YP_004411395.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR000408; KEGG: ttm:Tthe_2617 S-layer domain protein; PFAM: Regulator of chromosome condensation, RCC1; SPTR: uncharacterized protein; IMG reference gene:2503957083; PFAM: Listeria-Bacteroides repeat domain (List_Bact_rpt); Regulator of chromosome condensation (RCC1) repeat YP_004411396.1 COGs: COG0670 Integral membrane protein interacts with FtsH; InterPro IPR006214; KEGG: ssm:Spirs_1304 protein of unknown function UPF0005; PFAM: Inhibitor of apoptosis-promoting Bax1-related; SPTR: uncharacterized protein; IMG reference gene:2503957084; PFAM: Uncharacterised protein family UPF0005 YP_004411397.1 KEGG: srt:Srot_2429 ABC transporter-like protein; SPTR: ABC transporter related protein; IMG reference gene:2503957085 YP_004411398.1 COGs: COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase; InterPro IPR003959:IPR003593; KEGG: ssm:Spirs_1297 AAA ATPase central domain protein; PFAM: ATPase, AAA-type, core; SMART: ATPase, AAA+ type, core; SPTR: ATPase, AAA family; IMG reference gene:2503957086; PFAM: MgsA AAA+ ATPase C terminal; Holliday junction DNA helicase ruvB N-terminus YP_004411399.1 COGs: COG0544 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor); HAMAP: Trigger factor; InterPro IPR008881:IPR001179:IPR008880:IPR005215; KEGG: ssm:Spirs_1296 trigger factor; PFAM: Trigger factor, ribosome-binding, bacterial; Peptidyl-prolyl cis-trans isomerase, FKBP-type; Trigger factor, C-terminal, bacterial; SPTR: Trigger factor; TIGRFAM: Trigger factor; IMG reference gene:2503957092; PFAM: FKBP-type peptidyl-prolyl cis-trans isomerase; Bacterial trigger factor protein (TF) C-terminus; Bacterial trigger factor protein (TF); TIGRFAM: trigger factor YP_004411400.1 COGs: COG0740 Protease subunit of ATP-dependent Clp protease; HAMAP: Peptidase S14, ClpP; InterPro IPR001907; KEGG: ssm:Spirs_1295 ATP-dependent Clp protease, proteolytic subunit ClpP; PFAM: Peptidase S14, ClpP; PRIAM: Endopeptidase Clp; SPTR: ATP-dependent Clp protease proteolytic subunit; IMG reference gene:2503957093; PFAM: Clp protease; TIGRFAM: ATP-dependent Clp protease, proteolytic subunit ClpP YP_004411401.1 COGs: COG1219 ATP-dependent protease Clp ATPase subunit; HAMAP: Clp protease, ATP-binding subunit ClpX; InterProIPR010603:IPR013093:IPR019489:IPR004487:IPR 003593; KEGG: ssm:Spirs_1294 ATP-dependent Clp protease, ATP-binding subunit ClpX; PFAM: ATPase, AAA-2; Zinc finger, C4-type; Clp ATPase, C-terminal; SMART: ATPase, AAA+ type, core; SPTR: ATP-dependent Clp protease ATP-binding subunit ClpX; TIGRFAM: Clp protease, ATP-binding subunit ClpX; IMG reference gene:2503957094; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; ClpX C4-type zinc finger; TIGRFAM: endopeptidase Clp ATP-binding regulatory subunit (clpX) YP_004411402.1 COGs: COG0618 Exopolyphosphatase-related protein; InterPro IPR001667:IPR003156; KEGG: tde:TDE1479 DHH superfamily protein, subfamily 1; PFAM: Phosphoesterase, RecJ-like; Phosphoesterase, DHHA1; SPTR: DHH superfamily protein, subfamily 1; IMG reference gene:2503957095; PFAM: DHH family; DHHA1 domain YP_004411403.1 KEGG: ssm:Spirs_1290 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957096 YP_004411404.1 COGs: COG0127 Xanthosine triphosphate pyrophosphatase; HAMAP: Nucleoside-triphosphatase; InterPro IPR002637:IPR020922; KEGG: ssm:Spirs_1289 non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; PFAM: Ham1-like protein; PRIAM: Nucleoside-triphosphatase; SPTR: Nucleoside-triphosphatase; IMG reference gene:2503957097; PFAM: Ham1 family; TIGRFAM: non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family YP_004411405.1 COGs: COG1164 Oligoendopeptidase F; InterPro IPR013647:IPR001567:IPR004438; KEGG: ssm:Spirs_1288 oligoendopeptidase F; PFAM: Peptidase M3A/M3B, thimet/oligopeptidase F; Peptidase M3B, oligopeptidase F, N-terminal; SPTR: Oligoendopeptidase F; TIGRFAM: Peptidase M3B, oligoendopeptidase F; IMG reference gene:2503957098; PFAM: Oligopeptidase F; Peptidase M3; TIGRFAM: oligoendopeptidase F YP_004411406.1 KEGG: bay:RBAM_016980 BaeJ; SPTR: BaeJ; IMG reference gene:2503957100 YP_004411407.1 IMG reference gene:2503957101 YP_004411408.1 IMG reference gene:2503957102 YP_004411409.1 KEGG: afv:AFLA_136820 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957103 YP_004411410.1 KEGG: ath:AT2G32240 hypothetical protein; SPTR: Whole genome shotgun sequence of line PN40024, scaffold_16.assembly12x; IMG reference gene:2503957104 YP_004411411.1 InterPro IPR008160; KEGG: spv:SPH_0115 phage minor structural protein; PFAM: Collagen triple helix repeat; SPTR: Phage minor structural protein; IMG reference gene:2503957105; PFAM: Collagen triple helix repeat (20 copies) YP_004411412.1 KEGG: rce:RC1_0084 phage tail tape measure protein, SPTR: Phage tail tape measure protein, ; IMG reference gene:2503957106 YP_004411413.1 IMG reference gene:2503957107 YP_004411414.1 KEGG: smf:Smon_0099 cell division protein FtsZ; SPTR: Cell division protein ftsZ; IMG reference gene:2503957108 YP_004411415.1 KEGG: cim:CIMG_07117 hypothetical protein; SPTR: ribose-phosphate pyrophosphokinase; IMG reference gene:2503957109 YP_004411416.1 KEGG: cai:Caci_5320 amidohydrolase 3; SPTR: Amidohydrolase 3; IMG reference gene:2503957110 YP_004411417.1 KEGG: ecb:100051325 similar to Signal recognition particle 68 kDa protein (SRP68); SPTR: Uncharacterized protein; IMG reference gene:2503957111 YP_004411418.1 KEGG: avi:Avi_2997 Mu-like prophage protein; SPTR: uncharacterized protein; IMG reference gene:2503957112; PFAM: Phage virion morphogenesis family YP_004411419.1 KEGG: dap:Dacet_2235 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957113 YP_004411420.1 KEGG: dde:Dde_3377 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957114 YP_004411421.1 KEGG: dap:Dacet_2233 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957115 YP_004411422.1 InterPro IPR006528; KEGG: mrb:Mrub_1967 phage head morphogenesis protein, SPP1 gp7 family; PFAM: Phage head morphogenesis protein, SPP1 gp7; SPTR: Virion morphogenesis protein; TIGRFAM: Phage head morphogenesis protein, SPP1 gp7; IMG reference gene:2503957117; PFAM: Phage Mu protein F like protein; TIGRFAM: phage head morphogenesis protein, SPP1 gp7 family YP_004411423.1 COGs: COG4383 Mu-like prophage protein gp29; InterPro IPR009279; KEGG: dap:Dacet_2219 hypothetical protein; PFAM: Protein of unknown function DUF935; SPTR: uncharacterized protein; IMG reference gene:2503957118; PFAM: Protein of unknown function (DUF935) YP_004411424.1 KEGG: hth:HTH_0882 phage uncharacterized protein; SPTR: Phage uncharacterized protein; IMG reference gene:2503957119; PFAM: Terminase-like family YP_004411425.1 KEGG: amt:Amet_1950 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957120; PFAM: Protein of unknown function (DUF3486) YP_004411426.1 KEGG: hth:HTH_0884 hypothetical protein; SPTR: Predicted protein; IMG reference gene:2503957121 YP_004411427.1 KEGG: dtu:Dtur_1626 SMC domain protein; SPTR: SMC domain protein; IMG reference gene:2503957122 YP_004411428.1 KEGG: tel:tll0573 porin; major outer membrane protein; SPTR: Tll0573 protein; IMG reference gene:2503957123 YP_004411429.1 KEGG: hch:HCH_02233 cell wall biosynthesis glycosyltransferase; SPTR: Glycosyltransferase involved in cell wall biogenesis; IMG reference gene:2503957124 YP_004411430.1 KEGG: emi:Emin_1453 phage-related protein; SPTR: phage-related protein; IMG reference gene:2503957125 YP_004411431.1 KEGG: zpr:ZPR_0434 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957126 YP_004411432.1 KEGG: dre:550523 zgc:110200; SPTR: Non-LEE encoded type III effector C; IMG reference gene:2503957127 YP_004411433.1 KEGG: pth:PTH_2540 phosphoribosylamine-glycine ligase; SPTR: Phosphoribosylamine-glycine ligase; IMG reference gene:2503957128 YP_004411434.1 COGs: COG2932 transcriptional regulator protein; InterPro IPR001387:IPR019759; KEGG: lhk:LHK_01994 transcriptional regulator; PFAM: Helix-turn-helix type 3; Peptidase S24/S26A/S26B, conserved region; SMART: Helix-turn-helix type 3; SPTR: transcriptional repressor protein; IMG reference gene:2503957129; PFAM: Helix-turn-helix; Peptidase S24-like YP_004411435.1 KEGG: pzu:PHZ_c1565 predicted endonuclease containing a URI domain; SPTR: Predicted endonuclease containing a URI domain; IMG reference gene:2503957130 YP_004411436.1 KEGG: pyo:PY04213 hypothetical protein; SPTR: Death-inducer obliterator 1; IMG reference gene:2503957131 YP_004411437.1 KEGG: ape:APE_0946 succinate dehydrogenase iron-sulfur subunit; SPTR: Succinate dehydrogenase subunit B; IMG reference gene:2503957132 YP_004411438.1 InterPro IPR001387; KEGG: bfs:BF3179 DNA-binding protein; PFAM: Helix-turn-helix type 3; SPTR: uncharacterized protein; IMG reference gene:2503957133; PFAM: Helix-turn-helix YP_004411439.1 KEGG: dbr:Deba_1609 integrase catalytic region; SPTR: uncharacterized protein; IMG reference gene:2503957134; PFAM: Bacteriophage Mu transposase YP_004411440.1 COGs: COG2842 Uncharacterized ATPase transposase; KEGG: dde:Dde_3351 bacteriophage DNA transposition B protein; SPTR: uncharacterized protein; IMG reference gene:2503957135 YP_004411441.1 KEGG: dde:Dde_3352 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957136 YP_004411442.1 KEGG: rce:RC1_1103 GemA, modulation of host genes; SPTR: uncharacterized protein; IMG reference gene:2503957137; PFAM: Protein of unknown function (DUF1018) YP_004411443.1 KEGG: aat:D11S_0001 sulfate transport protein CysZ; SPTR: sulfate transport protein CysZ; IMG reference gene:2503957138; PFAM: Protein of unknown function (DUF3164) YP_004411444.1 KEGG: ctc:CTC02237 hypothetical protein; SPTR: Conserved protein; IMG reference gene:2503957139 YP_004411445.1 KEGG: sbi:SORBI_04g009980 hypothetical protein; SPTR: Lantibiotic mersacidin modifying enzyme; IMG reference gene:2503957140 YP_004411446.1 KEGG: cpy:Cphy_3624 hypothetical protein; SPTR: bacteriophage-related protein; IMG reference gene:2503957141 YP_004411447.1 InterPro IPR002104; KEGG: ssm:Spirs_R0031 integrase; PFAM: Integrase, catalytic core, phage; SPTR: Tn554-related transposase B; IMG reference gene:2503957142; PFAM: Phage integrase YP_004411448.1 InterPro IPR004360; KEGG: str:Sterm_2228 glyoxalase/bleomycin resistance protein/dioxygenase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; SPTR: Glyoxalase; IMG reference gene:2503957144; PFAM: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily YP_004411449.1 COGs: COG0177 EndoIII-related endonuclease; InterPro IPR003265:IPR003651; KEGG: sta:STHERM_c20610 endonuclease III; PFAM: HhH-GPD domain; Endonuclease III-like, iron-sulphur cluster loop motif; PRIAM: DNA-(apurinic or apyrimidinic site) lyase; SMART: HhH-GPD domain; SPTR: Endonuclease III; IMG reference gene:2503957146; PFAM: HhH-GPD superfamily base excision DNA repair protein; Iron-sulfur binding domain of endonuclease III; Helix-hairpin-helix motif; TIGRFAM: endonuclease III YP_004411450.1 KEGG: ckr:CKR_1799 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957147 YP_004411451.1 COGs: COG0602 Organic radical activating protein; InterPro IPR007197:IPR012837; KEGG: dhd:Dhaf_0350 anaerobic ribonucleoside-triphosphate reductase activating protein; PFAM: Radical SAM; SPTR: Anaerobic ribonucleoside-triphosphate reductase-activating protein; TIGRFAM: Ribonucleoside-triphosphate reductase activating, anaerobic; IMG reference gene:2503957148; PFAM: Radical SAM superfamily; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase activating protein YP_004411452.1 COGs: COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; InterPro IPR005144:IPR012833; KEGG: aoe:Clos_1144 anaerobic ribonucleoside triphosphate reductase; PFAM: ATP-cone; PRIAM: Ribonucleoside-triphosphate reductase; SPTR: Anaerobic ribonucleoside-triphosphate reductase; TIGRFAM: Ribonucleoside-triphosphate reductase, anaerobic; IMG reference gene:2503957149; PFAM: ATP cone domain; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase YP_004411453.1 COGs: COG3842 ABC-type spermidine/putrescine transport systems ATPase components; InterPro IPR003439:IPR013611:IPR003593:IPR005893; KEGG: tpp:TPASS_0652 spermidine/putrescine ABC transporter, ATP-binding protein; PFAM: ABC transporter-like; Transport-associated OB, type 2; PRIAM: Polyamine-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: Spermidine/putrescine import ATP-binding protein PotA; TIGRFAM: Spermidine/putrescine ABC transporter ATP-binding subunit; IMG reference gene:2503957150; PFAM: ABC transporter; TOBE domain; TIGRFAM: spermidine/putrescine ABC transporter ATP-binding subunit YP_004411454.1 COGs: COG1176 ABC-type spermidine/putrescine transport system permease component I; InterPro IPR000515; KEGG: tpp:TPASS_0653 spermidine/putrescine ABC transporter, permease; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Spermidine/putrescine transport system permease PotB; IMG reference gene:2503957151; PFAM: Binding-protein-dependent transport system inner membrane component YP_004411455.1 COGs: COG1177 ABC-type spermidine/putrescine transport system permease component II; InterPro IPR000515; KEGG: tpp:TPASS_0654 spermidine/putrescine ABC transporter, permease; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Spermidine/putrescine ABC transporter, permease; IMG reference gene:2503957152; PFAM: Binding-protein-dependent transport system inner membrane component YP_004411456.1 COGs: COG0687 Spermidine/putrescine-binding periplasmic protein; InterPro IPR006059; KEGG: tpp:TPASS_0655 spermidine/putrescine ABC transporter, periplasmic binding protein; PFAM: Bacterial extracellular solute-binding, family 1; SPTR: Spermidine/putrescine ABC transporter, periplasmic binding protein; IMG reference gene:2503957153; PFAM: Bacterial extracellular solute-binding protein YP_004411457.1 COGs: COG1670 Acetyltransferase including N-acetylase of ribosomal protein; InterPro IPR000182; KEGG: dhd:Dhaf_2686 GCN5-related N-acetyltransferase; PFAM: GCN5-related N-acetyltransferase (GNAT) domain; SPTR: uncharacterized protein; IMG reference gene:2503957154; PFAM: Acetyltransferase (GNAT) family YP_004411458.1 COGs: COG0545 FKBP-type peptidyl-prolyl cis-trans isomerase 1; InterPro IPR000774:IPR001179; KEGG: dol:Dole_1577 peptidylprolyl isomerase FKBP-type; PFAM: Peptidyl-prolyl cis-trans isomerase, FKBP-type; Peptidyl-prolyl cis-trans isomerase, FKBP-type, N-terminal; SPTR: Peptidyl-prolyl cis-trans isomerase; IMG reference gene:2503957155; PFAM: FKBP-type peptidyl-prolyl cis-trans isomerase; Domain amino terminal to FKBP-type peptidyl-prolyl isomerase YP_004411459.1 COGs: COG2731 Beta-galactosidase beta subunit; InterPro IPR004375; KEGG: sea:SeAg_B4753 cytoplasmic protein; PFAM: Conserved hypothetical protein CHP00022; SPTR: cytoplasmic protein; TIGRFAM: Conserved hypothetical protein CHP00022; IMG reference gene:2503957156; PFAM: Domain of unknown function (DUF386); TIGRFAM: uncharacterized protein, YhcH/YjgK/YiaL family YP_004411460.1 KEGG: eel:EUBELI_01147 cytidylate kinase; SPTR: uncharacterized protein; IMG reference gene:2503957157 YP_004411461.1 COGs: COG0373 Glutamyl-tRNA reductase; HAMAP: Tetrapyrrole biosynthesis, glutamyl-tRNA reductase; InterPro IPR015895:IPR006151:IPR000343; KEGG: cpy:Cphy_1368 glutamyl-tRNA reductase; PFAM: Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, N-terminal; Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase; PRIAM: Glutamyl-tRNA reductase; SPTR: uncharacterized protein; IMG reference gene:2503957158; PFAM: Shikimate / quinate 5-dehydrogenase; Glutamyl-tRNAGlu reductase, N-terminal domain; TIGRFAM: glutamyl-tRNA reductase YP_004411462.1 COGs: COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase; InterPro IPR012904:IPR003265; KEGG: cac:CA_C2707 8-oxoguanine-DNA-glycosylase; PFAM: 8-oxoguanine DNA glycosylase, N-terminal; HhH-GPD domain; PRIAM: DNA-(apurinic or apyrimidinic site) lyase; SMART: HhH-GPD domain; SPTR: DNA-(Apurinic or apyrimidinic site) lyase; IMG reference gene:2503957159; PFAM: HhH-GPD superfamily base excision DNA repair protein; 8-oxoguanine DNA glycosylase, N-terminal domain; TIGRFAM: 8-oxoguanine DNA-glycosylase (ogg) YP_004411463.1 COGs: COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain; InterPro IPR000728:IPR010918:IPR010074; KEGG: lpa:lpa_02423 phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase-related protein; AIR synthase-related protein, C-terminal; PRIAM: Phosphoribosylformylglycinamidine synthase; SPTR: Phosphoribosylformylglycinamidine synthase II; TIGRFAM: Phosphoribosylformylglycinamidine synthase II; IMG reference gene:2503957160; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: phosphoribosylformylglycinamidine synthase II YP_004411464.1 COGs: COG0150 Phosphoribosylaminoimidazole (AIR) synthetase; InterPro IPR000728:IPR010918:IPR004733; KEGG: ftn:FTN_0419 phosphoribosylaminoimidazole synthetase; PFAM: AIR synthase-related protein, C-terminal; AIR synthase-related protein; PRIAM: Phosphoribosylformylglycinamidine cyclo-ligase; SPTR: Phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: Phosphoribosylformylglycinamidine cyclo-ligase; IMG reference gene:2503957161; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: phosphoribosylaminoimidazole synthetase YP_004411465.1 COGs: COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase glutamine amidotransferase domain; InterPro IPR010075; KEGG: lpn:lpg1676 phosphoribosylformylglycinamidine synthase I; PRIAM: Phosphoribosylformylglycinamidine synthase; SPTR: Phosphoribosylformylglycinamidine synthase I; TIGRFAM: Phosphoribosylformylglycinamidine synthase I; IMG reference gene:2503957162; PFAM: Glutamine amidotransferase class-I; TIGRFAM: phosphoribosylformylglycinamidine synthase I YP_004411466.1 COGs: COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; HAMAP: SAICAR synthetase; InterPro IPR001636; KEGG: lpa:lpa_02418 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; PRIAM: Phosphoribosylaminoimidazolesuccinocarboxamide synthase; SPTR: Phosphoribosylaminoimidazole-succinocarboxamide synthase; IMG reference gene:2503957163; PFAM: SAICAR synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase YP_004411467.1 COGs: COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase; InterPro IPR000031; KEGG: dtu:Dtur_0269 phosphoribosylaminoimidazole carboxylase, catalytic subunit; PFAM: Phosphoribosylaminoimidazole carboxylase, core; SPTR: Phosphoribosylaminoimidazole carboxylase, catalytic subunit; IMG reference gene:2503957164; PFAM: AIR carboxylase; TIGRFAM: phosphoribosylaminoimidazole carboxylase, PurE protein YP_004411468.1 COGs: COG0034 Glutamine phosphoribosylpyrophosphate amidotransferase; InterPro IPR000583:IPR000836:IPR005854; KEGG: lpp:lpp1646 amidophosphoribosyltransferase; PFAM: Glutamine amidotransferase, class-II; Phosphoribosyltransferase; PRIAM: Amidophosphoribosyltransferase; SPTR: Amidophosphoribosyltransferase; TIGRFAM: Amidophosphoribosyl transferase; IMG reference gene:2503957165; PFAM: Phosphoribosyl transferase domain; Glutamine amidotransferases class-II; TIGRFAM: amidophosphoribosyltransferase YP_004411469.1 COGs: COG0151 Phosphoribosylamine-glycine ligase; HAMAP: Phosphoribosylglycinamide synthetase; InterProIPR020562:IPR020561:IPR020560:IPR002376:IPR 000115; KEGG: pif:PITG_12300 phosphoribosylglycinamide synthetase, PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Formyl transferase, N-terminal; PRIAM: Phosphoribosylamine--glycine ligase., Phosphoribosylglycinamide formyltransferase; SPTR: Phosphoribosylamine/glycine ligase; TIGRFAM: Phosphoribosylglycinamide synthetase; IMG reference gene:2503957166; PFAM: Phosphoribosylglycinamide synthetase, N domain; Formyl transferase; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C domain; TIGRFAM: phosphoribosylamine--glycine ligase; phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent YP_004411470.1 KEGG: nmu:Nmul_A0641 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957167 YP_004411471.1 COGs: COG0251 translation initiation inhibitor yjgF family; InterPro IPR006175:IPR006056; KEGG: tde:TDE2069 endoribonuclease L-PSP, PFAM: Endoribonuclease L-PSP; SPTR: uncharacterized protein; TIGRFAM: YjgF-like protein; IMG reference gene:2503957168; PFAM: Endoribonuclease L-PSP; TIGRFAM: endoribonuclease L-PSP YP_004411472.1 COGs: COG4225 unsaturated glucuronyl hydrolase involved in regulation of surface properties and related protein; InterPro IPR010905; KEGG: ote:Oter_1360 glycosy hydrolase; PFAM: Glycosyl hydrolase, family 88; SPTR: Glycosyl hydrolase 88; IMG reference gene:2503957169; PFAM: Glycosyl Hydrolase 88 YP_004411473.1 COGs: COG0395 ABC-type sugar transport system permease component; InterPro IPR000515; KEGG: sta:STHERM_c08200 transporter; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Transporter; IMG reference gene:2503957170; PFAM: Binding-protein-dependent transport system inner membrane component YP_004411474.1 COGs: COG1175 ABC-type sugar transport systems permease components; InterPro IPR000515; KEGG: sta:STHERM_c08210 transporter; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Transporter; IMG reference gene:2503957171; PFAM: Binding-protein-dependent transport system inner membrane component YP_004411475.1 COGs: COG1653 ABC-type sugar transport system periplasmic component; InterPro IPR006059; KEGG: sta:STHERM_c08220 extracellular solute-binding protein, family 1; PFAM: Bacterial extracellular solute-binding, family 1; SPTR: Extracellular solute-binding protein, family 1; IMG reference gene:2503957172; PFAM: Bacterial extracellular solute-binding protein YP_004411476.1 COGs: COG0133 Tryptophan synthase beta chain; HAMAP: Tryptophan synthase beta chain/beta chain-like; InterPro IPR001926:IPR023026:IPR006654; KEGG: pca:Pcar_1244 tryptophan synthase subunit beta; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; PRIAM: Tryptophan synthase; SPTR: Tryptophan synthase subunit beta; TIGRFAM: Tryptophan synthase, beta chain; IMG reference gene:2503957173; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: tryptophan synthase, beta subunit YP_004411477.1 InterPro IPR021139; KEGG: vpa:VP1078 hypothetical protein; PFAM: Domain of unknown function DUF88; SPTR: uncharacterized protein VP1078; IMG reference gene:2503957174; PFAM: Protein of unknown function DUF88 YP_004411478.1 KEGG: cpo:COPRO5265_1058 TM2 domain family protein; SPTR: Predicted membrane protein; IMG reference gene:2503957175; PFAM: TM2 domain YP_004411479.1 KEGG: brm:Bmur_1470 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957176 YP_004411480.1 COGs: COG4260 virion core protein (lumpy skin disease virus); KEGG: cce:Ccel_1422 antifreeze protein type I; SPTR: Antifreeze protein type I; IMG reference gene:2503957177; PFAM: SPFH domain / Band 7 family YP_004411481.1 COGs: COG0282 Acetate kinase; HAMAP: Acetate kinase; InterPro IPR000890:IPR004372; KEGG: ssm:Spirs_2158 acetate kinase; PFAM: Acetate/butyrate kinase; PRIAM: Acetate kinase; SPTR: Acetate kinase; TIGRFAM: Acetate kinase; IMG reference gene:2503957178; PFAM: Acetokinase; TIGRFAM: acetate kinase YP_004411482.1 COGs: COG0693 intracellular protease/amidase; InterPro IPR002818:IPR006287; KEGG: ssm:Spirs_2243 DJ-1 family protein; PFAM: ThiJ/PfpI; SPTR: protease; TIGRFAM: DJ-1; IMG reference gene:2503957179; PFAM: DJ-1/PfpI family; TIGRFAM: DJ-1 family protein YP_004411483.1 COGs: COG0722 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; InterPro IPR006218:IPR006219; KEGG: ssm:Spirs_2244 phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I/KDSA; PRIAM: 3-deoxy-7-phosphoheptulonate synthase; SPTR: Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive; TIGRFAM: DHAP synthase, class 1; IMG reference gene:2503957180; PFAM: DAHP synthetase I family; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase YP_004411484.1 InterPro IPR019734; KEGG: fgr:FG08956.1 hypothetical protein; SPTR: ATP/GTP binding protein; IMG reference gene:2503957181 YP_004411485.1 COGs: COG0683 ABC-type branched-chain amino acid transport systems periplasmic component; InterPro IPR001828; KEGG: aoe:Clos_2502 extracellular ligand-binding receptor; PFAM: Extracellular ligand-binding receptor; SPTR: Extracellular ligand-binding receptor; IMG reference gene:2503957182; PFAM: Receptor family ligand binding region YP_004411486.1 COGs: COG0559 Branched-chain amino acid ABC-type transport system permease components; InterPro IPR001851; KEGG: tjr:TherJR_2668 inner-membrane translocator; PFAM: ABC transporter permease; SPTR: Inner-membrane translocator; IMG reference gene:2503957183; PFAM: Branched-chain amino acid transport system / permease component YP_004411487.1 COGs: COG4177 ABC-type branched-chain amino acid transport system permease component; InterPro IPR001851; KEGG: aoe:Clos_2500 inner-membrane translocator; PFAM: ABC transporter permease; SPTR: Inner-membrane translocator; IMG reference gene:2503957184; PFAM: Branched-chain amino acid transport system / permease component YP_004411488.1 COGs: COG0411 ABC-type branched-chain amino acid transport systems ATPase component; InterPro IPR003439:IPR003593; KEGG: tjr:TherJR_2666 ABC transporter related protein; PFAM: ABC transporter-like; PRIAM: Sulfate-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter related protein; IMG reference gene:2503957185; PFAM: ABC transporter; Branched-chain amino acid ATP-binding cassette transporter YP_004411489.1 COGs: COG0410 ABC-type branched-chain amino acid transport systems ATPase component; InterPro IPR003439:IPR003593; KEGG: tjr:TherJR_2665 ABC transporter related protein; PFAM: ABC transporter-like; SMART: ATPase, AAA+ type, core; SPTR: uncharacterized protein; IMG reference gene:2503957186; PFAM: ABC transporter YP_004411490.1 COGs: COG1022 Long-chain acyl-CoA synthetase (AMP-forming); InterPro IPR000873; KEGG: ssm:Spirs_2245 AMP-dependent synthetase and ligase; PFAM: AMP-dependent synthetase/ligase; PRIAM: Long-chain-fatty-acid--CoA ligase; SPTR: AMP-dependent synthetase and ligase; IMG reference gene:2503957187; PFAM: AMP-binding enzyme YP_004411491.1 COGs: COG1235 Metal-dependent hydrolase of the beta-lactamase superfamily I; InterPro IPR001279; KEGG: ssm:Spirs_2246 hypothetical protein; PFAM: Beta-lactamase-like; SMART: Beta-lactamase-like; SPTR: Metallo-beta-lactamase domain protein; IMG reference gene:2503957188; PFAM: Metallo-beta-lactamase superfamily YP_004411492.1 COGs: COG0017 Aspartyl/asparaginyl-tRNA synthetase; HAMAP: Asparaginyl-tRNA synthetase, class IIb; InterPro IPR004365:IPR004364:IPR004522; KEGG: ssm:Spirs_2248 asparaginyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class II (D/K/N); Nucleic acid binding, OB-fold, tRNA/helicase-type; PRIAM: Asparagine--tRNA ligase; SPTR: Asparaginyl-tRNA synthetase; TIGRFAM: Asparaginyl-tRNA synthetase, class IIb; IMG reference gene:2503957189; PFAM: tRNA synthetases class II (D, K and N); OB-fold nucleic acid binding domain; TIGRFAM: asparaginyl-tRNA synthetase YP_004411493.1 COGs: COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; InterPro IPR000792; KEGG: sen:SACE_1981 protein kinase/LuxR family transcriptional regulator; PFAM: Transcription regulator LuxR, C-terminal; SMART: Transcription regulator LuxR, C-terminal; SPTR: Protein kinase/transcriptional regulator, LuxR family; IMG reference gene:2503957190; PFAM: Bacterial regulatory proteins, luxR family YP_004411494.1 COGs: COG1671 conserved hypothetical protein; HAMAP: Protein of unknown function DUF188; InterPro IPR003791; KEGG: mxa:MXAN_5526 YaiI/YqxD family protein; PFAM: Protein of unknown function DUF188; SPTR: UPF0178 protein MXAN_5526; IMG reference gene:2503957191; PFAM: Uncharacterized BCR, YaiI/YqxD family COG1671 YP_004411495.1 COGs: COG0205 6-phosphofructokinase; InterPro IPR000023:IPR011183; KEGG: ssm:Spirs_2255 diphosphate/fructose-6-phosphate1-phosphotransfe rase; PFAM: Phosphofructokinase domain; SPTR: Diphosphate--fructose-6-phosphate 1-phosphotransferase; TIGRFAM: Pyrophosphate-dependent phosphofructokinase PfpB; IMG reference gene:2503957192; PFAM: Phosphofructokinase; TIGRFAM: diphosphate--fructose-6-phosphate 1-phosphotransferase YP_004411496.1 COGs: COG3250 Beta-galactosidase/beta-glucuronidase; KEGG: ssm:Spirs_1196 beta-mannosidase; PRIAM: Beta-mannosidase; SPTR: Beta-mannosidase; IMG reference gene:2503957193; PFAM: domain; Glycosyl hydrolases family 2, TIM barrel domain YP_004411497.1 COGs: COG1454 Alcohol dehydrogenase class IV; InterPro IPR001670; KEGG: dsy:DSY1101 hypothetical protein; PFAM: Alcohol dehydrogenase, iron-type; PRIAM: Alcohol dehydrogenase; SPTR: uncharacterized protein; IMG reference gene:2503957194; PFAM: Iron-containing alcohol dehydrogenase YP_004411498.1 COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590; KEGG: dsy:DSY1102 hypothetical protein; PFAM: Aldehyde dehydrogenase domain; SPTR: uncharacterized protein; IMG reference gene:2503957195; PFAM: Aldehyde dehydrogenase YP_004411499.1 COGs: COG1653 ABC-type sugar transport system periplasmic component; InterPro IPR006059; KEGG: ssm:Spirs_2123 extracellular solute-binding protein family 1; PFAM: Bacterial extracellular solute-binding, family 1; SPTR: bacterial extracellular solute-binding protein; IMG reference gene:2503957196; PFAM: Bacterial extracellular solute-binding protein YP_004411500.1 COGs: COG0395 ABC-type sugar transport system permease component; InterPro IPR000515; KEGG: ssm:Spirs_2121 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Sugar ABC transporter permease; IMG reference gene:2503957197; PFAM: Binding-protein-dependent transport system inner membrane component YP_004411501.1 COGs: COG1175 ABC-type sugar transport systems permease components; InterPro IPR000515; KEGG: ssm:Spirs_2122 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Sugar ABC transporter permease; IMG reference gene:2503957198; PFAM: Binding-protein-dependent transport system inner membrane component YP_004411502.1 COGs: COG1940 Transcriptional regulator/sugar kinase; InterPro IPR000600; KEGG: ssm:Spirs_1197 ROK family protein; PFAM: ROK; SPTR: transcriptional regulator; IMG reference gene:2503957199; PFAM: ROK family YP_004411503.1 COGs: COG3525 N-acetyl-beta-hexosaminidase; InterPro IPR015883; KEGG: sli:Slin_4336 beta-N-acetylhexosaminidase; PFAM: Glycoside hydrolase, family 20, catalytic core; PRIAM: Beta-N-acetylhexosaminidase; SPTR: N-acetyl-beta-hexosaminidase; IMG reference gene:2503957200; PFAM: Glycosyl hydrolase 20, catalytic domain YP_004411504.1 COGs: COG1534 RNA-binding protein containing KH domain possibly ribosomal protein; InterPro IPR001890; KEGG: ssm:Spirs_2265 protein of unknown function UPF0044; PFAM: RNA-binding, CRM domain; SPTR: uncharacterized protein; IMG reference gene:2503957201; PFAM: CRS1 / YhbY (CRM) domain; TIGRFAM: RNA-binding protein, YhbY family YP_004411505.1 COGs: COG1022 Long-chain acyl-CoA synthetase (AMP-forming); InterPro IPR000873; KEGG: ssm:Spirs_2267 AMP-dependent synthetase and ligase; PFAM: AMP-dependent synthetase/ligase; PRIAM: Long-chain-fatty-acid--CoA ligase; SPTR: Long-chain-fatty-acid--CoA ligase, ; IMG reference gene:2503957202; PFAM: AMP-binding enzyme YP_004411506.1 COGs: COG0285 Folylpolyglutamate synthase; InterPro IPR013221:IPR004101:IPR001645; KEGG: ssm:Spirs_2271 FolC bifunctional protein; PFAM: Mur ligase, C-terminal; Mur ligase, central; SPTR: Folylpolyglutamate synthetase, ; TIGRFAM: Folylpolyglutamate synthetase; IMG reference gene:2503957203; PFAM: Mur ligase, glutamate ligase domain; Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase YP_004411507.1 COGs: COG1293 RNA-binding protein homologous to eukaryotic snRNP; InterPro IPR008616:IPR008532; KEGG: ssm:Spirs_2274 fibronectin-binding A domain protein; PFAM: Domain of unknown function DUF814; Fibronectin-binding A, N-terminal; SPTR: Fibronectin/fibrinogen-binding protein, internal deletion; IMG reference gene:2503957204; PFAM: Domain of unknown function (DUF814); Fibronectin-binding protein A N-terminus (FbpA) YP_004411508.1 KEGG: ttj:TTHA1711 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957205 YP_004411509.1 KEGG: sta:STHERM_c03340 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957206 YP_004411510.1 COGs: COG0324 tRNA delta(2)-isopentenylpyrophosphate transferase; HAMAP: tRNA delta(2)-isopentenylpyrophosphate transferase; InterPro IPR002627:IPR018022; KEGG: sta:STHERM_c12200 tRNA delta(2)-isopentenylpyrophosphate transferase; PFAM: tRNA isopentenyltransferase; PRIAM: tRNA isopentenyltransferase; SPTR: tRNA delta(2)-isopentenylpyrophosphate transferase; TIGRFAM: tRNA delta(2)-isopentenylpyrophosphate transferase; IMG reference gene:2503957207; PFAM: IPP transferase; TIGRFAM: tRNA dimethylallyltransferase YP_004411511.1 KEGG: rrs:RoseRS_1675 dehydrogenase catalytic domain-containing protein; SPTR: Predicted protein; IMG reference gene:2503957208 YP_004411512.1 COGs: COG1102 Cytidylate kinase; HAMAP: Cytidylate kinase, InterPro IPR011994:IPR011892; KEGG: tde:TDE1087 cytidylate kinase; PFAM: Cytidylate kinase domain; SPTR: Cytidylate kinase; TIGRFAM: Cytidylate kinase, IMG reference gene:2503957209; PFAM: Cytidylate kinase; TIGRFAM: cytidylate kinase YP_004411513.1 COGs: COG1561 Uncharacterized stress-induced protein; InterPro IPR013527:IPR013551:IPR005229; KEGG: sta:STHERM_c12240 protein YicC; PFAM: Domain of unknown function DUF1732; YicC-like, N-terminal; SPTR: Protein YicC; TIGRFAM: Conserved hypothetical protein CHP00255; IMG reference gene:2503957210; PFAM: YicC-like family, N-terminal region; Domain of unknown function (DUF1732); TIGRFAM: TIGR00255 family protein YP_004411514.1 COGs: COG0773 UDP-N-acetylmuramate-alanine ligase; InterPro IPR000713:IPR013221:IPR004101; KEGG: ssm:Spirs_2282 UDP-N-acetylmuramate/alanine ligase; PFAM: Mur ligase, C-terminal; Mur ligase, central; Mur ligase, N-terminal; PRIAM: UDP-N-acetylmuramate--L-alanine ligase; SPTR: UDP-N-acetylmuramate--L-alanine ligase; IMG reference gene:2503957211; PFAM: Mur ligase, catalytic domain; Mur ligase, glutamate ligase domain; Mur ligase middle domain YP_004411515.1 KEGG: pbe:PB000454.03.0 hypothetical protein; SPTR: Homoserine O-acetyltransferase; IMG reference gene:2503957212 YP_004411516.1 COGs: COG0769 UDP-N-acetylmuramyl tripeptide synthase; HAMAP:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-di aminopimelateligase; InterPro IPR000713:IPR013221:IPR004101:IPR005761; KEGG: rrs:RoseRS_0794 UDP-N-acetylmuramyl-tripeptide synthetase; PFAM: Mur ligase, central; Mur ligase, N-terminal; Mur ligase, C-terminal; PRIAM:UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelateligase; SPTR: UDP-N-acetylmuramyl-tripeptide synthetase; TIGRFAM:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6- diaminopimelateligase; IMG reference gene:2503957213; PFAM: Mur ligase, glutamate ligase domain; Mur ligase, catalytic domain; Mur ligase middle domain; TIGRFAM: UDP-N-acetylmuramyl-tripeptide synthetase YP_004411517.1 COGs: COG1181 D-alanine-D-alanine ligase and related ATP-grasp protein; HAMAP: D-alanine--D-alanine ligase; InterPro IPR011127:IPR011095:IPR005905; KEGG: ara:Arad_1819 D-alanyl-alanine synthetase A; PFAM: D-alanine--D-alanine ligase, N-terminal; D-alanine--D-alanine ligase, C-terminal; PRIAM: D-alanine--D-alanine ligase; SPTR: D-alanine-D-alanine ligase; IMG reference gene:2503957214; PFAM: D-ala D-ala ligase N-terminus; D-ala D-ala ligase C-terminus; TIGRFAM: D-alanine--D-alanine ligase YP_004411518.1 COGs: COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair; HAMAP: DNA polymerase IV; InterPro IPR001126:IPR022880; KEGG: ssm:Spirs_2898 DNA-directed DNA polymerase; PFAM: DNA-repair protein, UmuC-like; PRIAM: DNA-directed DNA polymerase; SPTR: DNA polymerase IV; IMG reference gene:2503957215; PFAM: impB/mucB/samB family C-terminal; impB/mucB/samB family YP_004411519.1 COGs: COG0219 rRNA methylase (SpoU class); InterPro IPR001537; KEGG: dae:Dtox_0805 RNA methyltransferase, TrmH family, group 2; PFAM: tRNA/rRNA methyltransferase, SpoU; SPTR: uncharacterized protein; IMG reference gene:2503957216; PFAM: SpoU rRNA Methylase; TIGRFAM: rRNA methylase, , group 2 YP_004411520.1 COGs: COG0345 Pyrroline-5-carboxylate reductase; InterPro IPR004455:IPR000304; KEGG: ssm:Spirs_2903 pyrroline-5-carboxylate reductase; PFAM: NADP oxidoreductase, coenzyme F420-dependent; PRIAM: Pyrroline-5-carboxylate reductase; SPTR: Pyrroline-5-carboxylate reductase; TIGRFAM: Pyrroline-5-carboxylate reductase; IMG reference gene:2503957217; PFAM: NADP oxidoreductase coenzyme F420-dependent; TIGRFAM: pyrroline-5-carboxylate reductase YP_004411521.1 COGs: COG0172 Seryl-tRNA synthetase; HAMAP: Seryl-tRNA synthetase, class IIa; InterPro IPR015866:IPR002314:IPR002317; KEGG: tde:TDE2307 seryl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain; Seryl-tRNA synthetase, class IIa, N-terminal; PRIAM: Serine--tRNA ligase; SPTR: Seryl-tRNA synthetase; TIGRFAM: Seryl-tRNA synthetase, class IIa; IMG reference gene:2503957218; PFAM: Seryl-tRNA synthetase N-terminal domain; tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: seryl-tRNA synthetase YP_004411522.1 COGs: COG1488 Nicotinic acid phosphoribosyltransferase; InterPro IPR015977:IPR006405; KEGG: ssm:Spirs_2906 nicotinate phosphoribosyltransferase; PFAM: Nicotinate phosphoribosyltransferase-like; SPTR: Nicotinate phosphoribosyltransferase; TIGRFAM: Nicotinate phosphoribosyltransferase IMG reference gene:2503957219; PFAM: Nicotinate phosphoribosyltransferase (NAPRTase) family; TIGRFAM: nicotinate phosphoribosyltransferase YP_004411523.1 COGs: COG0860 N-acetylmuramoyl-L-alanine amidase; InterPro IPR002508; KEGG: ssm:Spirs_2928 cell wall hydrolase/autolysin; PFAM: Cell wall hydrolase/autolysin, catalytic; SMART: Cell wall hydrolase/autolysin, catalytic; SPTR: N-acetylmuramoyl-L-alanine amidase; IMG reference gene:2503957220; PFAM: N-acetylmuramoyl-L-alanine amidase YP_004411524.1 KEGG: ssm:Spirs_2932 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957221 YP_004411525.1 COGs: COG0263 Glutamate 5-kinase; HAMAP: Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase; InterPro IPR005715:IPR001048:IPR002478; KEGG: sta:STHERM_c19790 glutamate 5-kinase; PFAM: Aspartate/glutamate/uridylate kinase; Pseudouridine synthase/archaeosine transglycosylase; SMART: Pseudouridine synthase/archaeosine transglycosylase; SPTR: Glutamate 5-kinase; TIGRFAM: Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase; IMG reference gene:2503957222; PFAM: PUA domain; Amino acid kinase; TIGRFAM: glutamate 5-kinase YP_004411526.1 COGs: COG0014 Gamma-glutamyl phosphate reductase; InterPro IPR000965; KEGG: sta:STHERM_c19780 gamma-glutamyl phosphate reductase; PRIAM: Glutamate-5-semialdehyde dehydrogenase; SPTR: Gamma-glutamyl phosphate reductase; TIGRFAM: Gamma-glutamyl phosphate reductase GPR; IMG reference gene:2503957223; PFAM: Aldehyde dehydrogenase; TIGRFAM: gamma-glutamyl phosphate reductase YP_004411527.1 COGs: COG2252 Permease; InterPro IPR006043; KEGG: bpo:BP951000_1268 integral membrane transport protein; PFAM: Xanthine/uracil/vitamin C permease; SPTR: Integral membrane transport protein; IMG reference gene:2503957224; PFAM: Permease YP_004411528.1 KEGG: dps:DP1907 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957225 YP_004411529.1 KEGG: tpv:TP04_0148 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957226 YP_004411530.1 COGs: COG0084 Mg-dependent DNase; InterPro IPR001130:IPR015991; KEGG: ssm:Spirs_2388 hydrolase, TatD family; PFAM: Deoxyribonuclease, TatD-related; SPTR: Sec-independent protein translocase TatD; TIGRFAM: Deoxyribonuclease, TatD Mg-dependent, prokaryote; IMG reference gene:2503957228; PFAM: TatD related DNase; TIGRFAM: hydrolase, TatD family YP_004411531.1 COGs: COG0191 Fructose/tagatose bisphosphate aldolase; InterPro IPR000771:IPR011289; KEGG: ssm:Spirs_2588 fructose-1,6-bisphosphate aldolase, class II; PFAM: Ketose-bisphosphate aldolase, class-II; PRIAM: Fructose-bisphosphate aldolase; SPTR: uncharacterized protein; TIGRFAM: Fructose-1,6-bisphosphate aldolase, class 2; Ketose-bisphosphate aldolase, class-II; IMG reference gene:2503957229; PFAM: Fructose-bisphosphate aldolase class-II; TIGRFAM: ketose-bisphosphate aldolases; fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist YP_004411532.1 COGs: COG0655 Multimeric flavodoxin WrbA; InterPro IPR005025; KEGG: ccb:Clocel_4239 NADPH-dependent FMN reductase; PFAM: NADPH-dependent FMN reductase; SPTR: Iron-sulfur flavoprotein; IMG reference gene:2503957230; PFAM: NADPH-dependent FMN reductase YP_004411533.1 COGs: COG0290 Translation initiation factor 3 (IF-3); HAMAP: Translation initiation factor 3; InterPro IPR001288:IPR019814:IPR019815; KEGG: ssm:Spirs_2590 translation initiation factor IF-3; PFAM: Translation initiation factor 3, N-terminal; Translation initiation factor 3, C-terminal; SPTR: Translation initiation factor IF-3; TIGRFAM: Translation initiation factor 3; IMG reference gene:2503957231; PFAM: Translation initiation factor IF-3, C-terminal domain; Translation initiation factor IF-3, N-terminal domain; TIGRFAM: translation initiation factor IF-3 YP_004411534.1 HAMAP: Ribosomal protein L35, non-mitochondrial; InterPro IPR001706:IPR021137; KEGG: ssm:Spirs_2591 ribosomal protein L35; PFAM: Ribosomal protein L35; SPTR: 50S ribosomal protein L35; TIGRFAM: Ribosomal protein L35, non-mitochondrial; IMG reference gene:2503957232; PFAM: Ribosomal protein L35; TIGRFAM: ribosomal protein L35 YP_004411535.1 COGs: COG0292 Ribosomal protein L20; HAMAP: Ribosomal protein L20; InterPro IPR005813; KEGG: ssm:Spirs_2592 ribosomal protein L20; PFAM: Ribosomal protein L20; SPTR: 50S ribosomal protein L20; TIGRFAM: Ribosomal protein L20; IMG reference gene:2503957233; PFAM: Ribosomal protein L20; TIGRFAM: ribosomal protein L20 YP_004411536.1 KEGG: tde:TDE2153 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957234 YP_004411537.1 InterPro IPR001440:IPR019734; KEGG: ssm:Spirs_2596 tetratricopeptide TPR_2 repeat protein; PFAM: Tetratricopeptide TPR-1; SPTR: TPR domain protein; IMG reference gene:2503957235 YP_004411538.1 COGs: COG0802 ATPase or kinase; InterPro IPR003442; KEGG: tde:TDE1469 hypothetical protein; PFAM: Uncharacterised protein family UPF0079, ATPase bacteria; SPTR: uncharacterized protein; TIGRFAM: Uncharacterised protein family UPF0079, ATPase bacteria; IMG reference gene:2503957236; PFAM: Uncharacterised P-loop hydrolase UPF0079; TIGRFAM: ATPase, YjeE family YP_004411539.1 COGs: COG1214 Inactive homolog of metal-dependent protease molecular chaperone; InterPro IPR000905:IPR022496; KEGG: ssm:Spirs_2605 peptidase M22 glycoprotease; PFAM: Peptidase M22, glycoprotease; SPTR: Peptidase M22, glycoprotease; TIGRFAM: Conserved hypothetical protein CHP03725, YeaZ; IMG reference gene:2503957237; PFAM: Glycoprotease; TIGRFAM: universal bacterial protein YeaZ YP_004411540.1 COGs: COG0492 Thioredoxin reductase; InterPro IPR013027:IPR005982; KEGG: ssm:Spirs_2612 thioredoxin reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PRIAM: Thioredoxin-disulfide reductase; SPTR: Thioredoxin reductase; TIGRFAM: Thioredoxin reductase; IMG reference gene:2503957238; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: thioredoxin-disulfide reductase YP_004411541.1 COGs: COG0297 Glycogen synthase; HAMAP: Glycogen/starch synthases, ADP-glucose type; InterPro IPR011835:IPR013534:IPR001296; KEGG: gsu:GSU3257 glycogen synthase; PFAM: Starch synthase, catalytic domain; Glycosyl transferase, group 1; PRIAM: Starch synthase; SPTR: Glycogen synthase 2; TIGRFAM: Glycogen/starch synthases, ADP-glucose type; IMG reference gene:2503957239; PFAM: Starch synthase catalytic domain; Glycosyl transferases group 1; TIGRFAM: glycogen/starch synthases, ADP-glucose type YP_004411542.1 COGs: COG0448 ADP-glucose pyrophosphorylase; InterPro IPR005835; KEGG: ssm:Spirs_2619 nucleotidyl transferase; PFAM: Nucleotidyl transferase; PRIAM: Glucose-1-phosphate adenylyltransferase; SPTR: Glucose-1-phosphate adenylyltransferase; IMG reference gene:2503957240; PFAM: Nucleotidyl transferase; TIGRFAM: glucose-1-phosphate adenylyltransferase YP_004411543.1 KEGG: ssm:Spirs_2621 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957241 YP_004411544.1 COGs: COG0063 sugar kinase; InterPro IPR004443:IPR000631; KEGG: ssm:Spirs_2623 carbohydrate kinase, YjeF related protein; PFAM: YjeF-related protein, N-terminal; Uncharacterised protein family, carbohydrate kinase-related; SPTR: YjeF family protein; TIGRFAM: Uncharacterised protein family, carbohydrate kinase-related; YjeF-related protein, N-terminal; IMG reference gene:2503957242; PFAM: YjeF-related protein N-terminus; Carbohydrate kinase; TIGRFAM: yjeF N-terminal region; yjeF C-terminal region, hydroxyethylthiazole kinase-related YP_004411545.1 InterPro IPR001387; KEGG: dae:Dtox_2429 transcriptional regulator, XRE family; PFAM: Helix-turn-helix type 3; SMART: Helix-turn-helix type 3; SPTR: Transcriptional regulator, XRE family; IMG reference gene:2503957243; PFAM: Helix-turn-helix YP_004411546.1 COGs: COG4143 ABC-type thiamine transport system periplasmic component; InterPro IPR006059:IPR005948; KEGG: ssm:Spirs_1695 ABC transporter, periplasmic binding protein, ThiB subfamily; PFAM: Bacterial extracellular solute-binding, family 1; SPTR: ABC-type thiamine transport system, periplasmic component; TIGRFAM: Thiamine ABC transporter periplasmic binding protein; IMG reference gene:2503957244; PFAM: Bacterial extracellular solute-binding protein; TIGRFAM: ABC transporter periplasmic binding protein, thiB subfamily YP_004411547.1 COGs: COG1178 ABC-type Fe3+ transport system permease component; InterPro IPR000515; KEGG: ssm:Spirs_1694 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Maltooligosaccharide ABC transporter, permease component; IMG reference gene:2503957245; PFAM: Binding-protein-dependent transport system inner membrane component YP_004411548.1 COGs: COG3842 ABC-type spermidine/putrescine transport systems ATPase components; InterPro IPR003439:IPR003593; KEGG: hut:Huta_0390 ABC transporter related; PFAM: ABC transporter-like; PRIAM: Fe(3+)-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter related; IMG reference gene:2503957246; PFAM: ABC transporter YP_004411549.1 COGs: COG0556 Helicase subunit of the DNA excision repair complex; HAMAP: Excinuclease ABC, B subunit; InterProIPR004807:IPR006935:IPR001650:IPR001943:IPR 014001; KEGG: ssm:Spirs_2331 excinuclease ABC, B subunit; PFAM: Helicase, C-terminal; Restriction endonuclease, type I, R subunit/Type III, Res subunit; UvrB/UvrC protein; SMART: DEAD-like helicase, N-terminal; Helicase, C-terminal; SPTR: UvrABC system protein B; TIGRFAM: Excinuclease ABC, B subunit; IMG reference gene:2503957247; PFAM: Helicase conserved C-terminal domain; UvrB/uvrC motif; Type III restriction enzyme, res subunit; Ultra-violet resistance protein B; TIGRFAM: excinuclease ABC, B subunit YP_004411550.1 COGs: COG0265 Trypsin-like serine protease typically periplasmic contain C-terminal PDZ domain; InterPro IPR001254:IPR001478; KEGG: ssm:Spirs_2332 peptidase S1 and S6 chymotrypsin/Hap; PFAM: Peptidase S1/S6, chymotrypsin/Hap; PDZ/DHR/GLGF; PRIAM: HtrA2 peptidase; SMART: PDZ/DHR/GLGF; SPTR: Periplasmic serine protease DO (HtrA-1); IMG reference gene:2503957248; PFAM: Trypsin YP_004411551.1 COGs: COG1477 Membrane-associated lipoprotein involved in thiamine biosynthesis; InterPro IPR003374; KEGG: tte:TTE2482 thiamine biosynthesis lipoprotein; PFAM: Thiamine synthesis ApbE/UPF0280; SPTR: ApbE family lipoprotein; IMG reference gene:2503957249; PFAM: ApbE family YP_004411552.1 COGs: COG0524 Sugar kinase ribokinase; InterPro IPR011611; KEGG: msv:Mesil_1102 PfkB domain protein; PFAM: Carbohydrate/purine kinase; PRIAM: Fructokinase; SPTR: PfkB domain protein; IMG reference gene:2503957250; PFAM: pfkB family carbohydrate kinase YP_004411553.1 COGs: COG3294 conserved hypothetical protein; InterPro IPR006674:IPR003607; KEGG: ssm:Spirs_0575 metal dependent phosphohydrolase; PFAM: Metal-dependent phosphohydrolase, HD subdomain; SMART: Metal-dependent phosphohydrolase, HD domain; SPTR: uncharacterized protein; IMG reference gene:2503957251; PFAM: HD domain YP_004411554.1 COGs: COG0008 Glutamyl- and glutaminyl-tRNA synthetase; HAMAP: Glutaminyl-tRNA synthetase, bacterial; InterPro IPR022861:IPR020058:IPR020059:IPR004514; KEGG: ssm:Spirs_1481 glutaminyl-tRNA synthetase; PFAM: Glutamyl/glutaminyl-tRNA synthetase, class Ic, catalytic domain; Glutamyl/glutaminyl-tRNA synthetase, class Ic, anti-codon binding domain; PRIAM: Glutamine--tRNA ligase; SPTR: Glutaminyl-tRNA synthetase; TIGRFAM: Glutaminyl-tRNA synthetase, class Ic; IMG reference gene:2503957252; PFAM: tRNA synthetases class I (E and Q), catalytic domain; tRNA synthetases class I (E and Q), anti-codon binding domain; TIGRFAM: glutaminyl-tRNA synthetase YP_004411555.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR013378:IPR000408:IPR011110; KEGG: aeh:Mlg_2687 regulator of chromosome condensation, RCC1; PFAM: Listeria/Bacterioides repeat; Regulator of chromosome condensation, RCC1; Two component regulator propeller; SPTR: uncharacterized protein; IMG reference gene:2503957253; PFAM: Listeria-Bacteroides repeat domain (List_Bact_rpt); Regulator of chromosome condensation (RCC1) repeat YP_004411556.1 InterPro IPR000792; KEGG: rle:RL0075 GerE family transcriptional regulator; PFAM: Transcription regulator LuxR, C-terminal; SMART: Transcription regulator LuxR, C-terminal; SPTR: DNA-binding response regulator; IMG reference gene:2503957254; PFAM: Bacterial regulatory proteins, luxR family YP_004411557.1 COGs: COG1592 Rubrerythrin; InterPro IPR003251; KEGG: cpy:Cphy_0524 rubrerythrin; PFAM: Rubrerythrin; SPTR: Rubrerythrin; IMG reference gene:2503957255; PFAM: Rubrerythrin YP_004411558.1 COGs: COG0735 Fe2+/Zn2+ uptake regulation protein; InterPro IPR002481; KEGG: eel:EUBELI_20027 Fur family transcriptional regulator, ferric uptake regulator; PFAM: Ferric-uptake regulator; SPTR: uncharacterized protein; IMG reference gene:2503957256; PFAM: Ferric uptake regulator family YP_004411559.1 COGs: COG1092 SAM-dependent methyltransferase; KEGG: ssm:Spirs_1479 rRNA (guanine-N(2)-)-methyltransferase; PRIAM: rRNA (guanine-N(2)-)-methyltransferase; SPTR: Ribosomal RNA large subunit methyltransferase L; IMG reference gene:2503957257; PFAM: S-adenosylmethionine-dependent methyltransferase YP_004411560.1 COGs: COG5421 Transposase; InterPro IPR002559; KEGG: cob:COB47_1677 transposase IS4 family protein; PFAM: Transposase, IS4-like; SPTR: Transposase IS4 family protein; IMG reference gene:2503957258; PFAM: Transposase DDE domain YP_004411561.1 KEGG: ssm:Spirs_1477 hypothetical protein; SPTR: Predicted protein; IMG reference gene:2503957259 YP_004411562.1 COGs: COG1109 Phosphomannomutase; InterPro IPR005844:IPR005845:IPR005846:IPR005843; KEGG: ssm:Spirs_1476 phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; PFAM: Alpha-D-phosphohexomutase, alpha/beta/alpha domain I; Alpha-D-phosphohexomutase, alpha/beta/alpha domain II; Alpha-D-phosphohexomutase, alpha/beta/alpha domain III; Alpha-D-phosphohexomutase, C-terminal; SPTR: Phosphomannomutase; IMG reference gene:2503957260; PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosphoglucomutase/phosphomannomutase, C-terminal domain; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I YP_004411563.1 COGs: COG1087 UDP-glucose 4-epimerase; InterPro IPR001509:IPR005886; KEGG: plt:Plut_0420 UDP-glucose 4-epimerase; PFAM: NAD-dependent epimerase/dehydratase; PRIAM: UDP-glucose 4-epimerase; SPTR: UDP-glucose 4-epimerase; TIGRFAM: UDP-glucose 4-epimerase; IMG reference gene:2503957261; PFAM: NAD dependent epimerase/dehydratase; TIGRFAM: UDP-glucose-4-epimerase YP_004411564.1 COGs: COG1321 Mn-dependent transcriptional regulator protein; InterPro IPR022687:IPR022689; KEGG: apv:Apar_1294 iron (metal) dependent repressor, DtxR family; PFAM: Iron dependent repressor, N-terminal; SMART: Iron dependent repressor, diptheria toxin type; SPTR: uncharacterized protein; IMG reference gene:2503957262; PFAM: Iron dependent repressor, N-terminal DNA binding domain YP_004411565.1 InterPro IPR007167; KEGG: cbt:CLH_2780 hypothetical protein; PFAM: Ferrous iron transporter, FeoA subunit; SMART: Ferrous iron transporter, FeoA subunit; SPTR: Conserved domain protein; IMG reference gene:2503957263; PFAM: FeoA domain YP_004411566.1 COGs: COG1918 Fe2+ transport system protein A; InterPro IPR007167; KEGG: eel:EUBELI_00573 ferrous iron transport protein A; PFAM: Ferrous iron transporter, FeoA subunit; SMART: Ferrous iron transporter, FeoA subunit; SPTR: uncharacterized protein; IMG reference gene:2503957264; PFAM: FeoA domain YP_004411567.1 COGs: COG0370 Fe2+ transport system protein B; InterProIPR002917:IPR011619:IPR011642:IPR011640:IPR 005225:IPR003373; KEGG: cbt:CLH_2778 ferrous iron transport protein B; PFAM: GTP-binding protein, HSR1-related; Ferrous iron transport protein B, N-terminal; Nucleoside recognition; Ferrous iron transport protein B, C-terminal; SPTR: Ferrous iron transport protein B; TIGRFAM: Ferrous iron transport protein B; Small GTP-binding protein; IMG reference gene:2503957265; PFAM: Ferrous iron transport protein B; Ferrous iron transport protein B C terminus; Nucleoside recognition; TIGRFAM: ferrous iron transporter FeoB; small GTP-binding protein domain YP_004411568.1 KEGG: fma:FMG_1212 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957266 YP_004411569.1 COGs: COG2249 NADPH-quinone reductase (modulator of drug activity B); InterPro IPR003680; KEGG: cbi:CLJ_B0889 flavodoxin-like fold domain protein; PFAM: Flavodoxin-like fold; SPTR: Flavodoxin-like fold domain protein; IMG reference gene:2503957267; PFAM: Flavodoxin-like fold YP_004411570.1 COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterPro IPR004843:IPR008334; KEGG: ppy:PPE_01086 5'-nucleotidase/2',3'-cyclic phosphodiesterase; PFAM: 5'-Nucleotidase, C-terminal; Metallo-dependent phosphatase; PRIAM: 5'-nucleotidase; SPTR: 5'-nucleotidase/2',3'-cyclic phosphodiesterase; IMG reference gene:2503957269; PFAM: Calcineurin-like phosphoesterase; 5'-nucleotidase, C-terminal domain YP_004411571.1 KEGG: ssm:Spirs_2236 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957270 YP_004411572.1 COGs: COG0759 conserved hypothetical protein; HAMAP: Protein of unknown function DUF37; InterPro IPR002696; KEGG: lbu:LBUL_0647 hypothetical protein; PFAM: Protein of unknown function DUF37; SPTR: UPF0161 protein HMPREF0044_0040; TIGRFAM: Protein of unknown function DUF37; IMG reference gene:2503957271; PFAM: Domain of unknown function DUF37; TIGRFAM: conserved hypothetical protein YidD YP_004411573.1 COGs: COG0572 Uridine kinase; HAMAP: Uridine kinase; InterPro IPR000764:IPR006083; KEGG: ssm:Spirs_2239 uridine kinase; PFAM: Phosphoribulokinase/uridine kinase; SPTR: Uridine kinase; TIGRFAM: Uridine kinase; IMG reference gene:2503957272; PFAM: Phosphoribulokinase / Uridine kinase; TIGRFAM: uridine kinase YP_004411574.1 COGs: COG2017 Galactose mutarotase; InterPro IPR008183; KEGG: sta:STHERM_c02560 aldose 1-epimerase; PFAM: Aldose 1-epimerase; PRIAM: Aldose 1-epimerase; SPTR: Aldose 1-epimerase; manually curated; IMG reference gene:2503957273; PFAM: Aldose 1-epimerase YP_004411575.1 COGs: COG0481 Membrane GTPase LepA; HAMAP: GTP-binding protein LepA; InterProIPR006297:IPR000795:IPR004161:IPR000640:IPR 013842:IPR005225; KEGG: ssm:Spirs_1828 GTP-binding protein LepA; PFAM: GTP-binding protein LepA, C-terminal; Protein synthesis factor, GTP-binding; Translation elongation factor EFTu/EF1A, domain 2; Translation elongation factor EFG/EF2, C-terminal; SPTR: GTP-binding protein lepA; TIGRFAM: GTP-binding protein LepA; Small GTP-binding protein; IMG reference gene:2503957274; PFAM: Elongation factor Tu domain 2; Elongation factor G C-terminus; Elongation factor Tu GTP binding domain; GTP-binding protein LepA C-terminus; TIGRFAM: GTP-binding protein LepA; small GTP-binding protein domain YP_004411576.1 COGs: COG0465 ATP-dependent Zn protease; InterProIPR011546:IPR003959:IPR000642:IPR005936:IPR 003593; KEGG: ssm:Spirs_1817 ATP-dependent metalloprotease FtsH; PFAM: Peptidase M41; ATPase, AAA-type, core; Peptidase M41, FtsH extracellular; PRIAM: Microtubule-severing ATPase; SMART: ATPase, AAA+ type, core; SPTR: Cell division protease FtsH; TIGRFAM: Peptidase M41, FtsH; IMG reference gene:2503957275; PFAM: FtsH Extracellular; Peptidase M41; ATPase associated with various cellular activities (AAA); TIGRFAM: ATP-dependent metalloprotease FtsH YP_004411577.1 COGs: COG0037 ATPase of the PP-loop superfamily protein implicated in cell cycle control; HAMAP: Lysidine-tRNA(Ile) synthetase; InterPro IPR012094:IPR011063:IPR012795:IPR012796; KEGG: ssm:Spirs_1816 tRNA(Ile)-lysidine synthetase; PFAM: tRNA(Ile)-lysidine/2-thiocytidine synthase; SMART: Lysidine-tRNA(Ile) synthetase, C-terminal; SPTR: tRNA(Ile)-lysidine synthase; TIGRFAM: Lysidine-tRNA(Ile) synthetase, N-terminal; Lysidine-tRNA(Ile) synthetase, C-terminal; IMG reference gene:2503957276; PFAM: PP-loop family; TIGRFAM: tRNA(Ile)-lysidine synthetase, C-terminal domain; tRNA(Ile)-lysidine synthetase, N-terminal domain YP_004411578.1 COGs: COG0193 Peptidyl-tRNA hydrolase; InterPro IPR001328; KEGG: ssm:Spirs_1815 peptidyl-tRNA hydrolase; PFAM: Peptidyl-tRNA hydrolase; PRIAM: Aminoacyl-tRNA hydrolase; SPTR: Peptidyl-tRNA hydrolase; TIGRFAM: Peptidyl-tRNA hydrolase; IMG reference gene:2503957277; PFAM: Peptidyl-tRNA hydrolase; TIGRFAM: peptidyl-tRNA hydrolase YP_004411579.1 COGs: COG1825 Ribosomal protein L25 (general stress protein Ctc); HAMAP: Ribosomal protein L25, long-form; InterPro IPR001021:IPR020055; KEGG: tde:TDE1340 50S ribosomal protein L25/general stress protein Ctc; PFAM: Ribosomal protein L25, short-form; SPTR: 50S ribosomal protein L25; TIGRFAM: Ribosomal protein L25, long-form; IMG reference gene:2503957278; PFAM: Ribosomal L25p family; TIGRFAM: ribosomal protein L25, Ctc-form YP_004411580.1 COGs: COG2768 Uncharacterized Fe-S center protein; KEGG: afn:Acfer_0536 uncharacterized Fe-S center protein; SPTR: uncharacterized protein; manually curated; IMG reference gene:2503957279 YP_004411581.1 COGs: COG2088 Uncharacterized protein involved in the regulation of septum location; HAMAP: septation protein spoVG; InterPro IPR007170; KEGG: ccb:Clocel_3809 SpoVG family protein; PFAM: Sporulation stage V, protein G; SPTR: SpoVG family protein; IMG reference gene:2503957281; PFAM: SpoVG YP_004411582.1 COGs: COG1947 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase; HAMAP: 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; InterPro IPR004424:IPR006204; KEGG: sta:STHERM_c10370 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; PFAM: GHMP kinase; SPTR: 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; TIGRFAM: 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; IMG reference gene:2503957282; PFAM: GHMP kinases N terminal domain; TIGRFAM: 4-diphosphocytidyl-2C-methyl-D-erythritol kinase YP_004411583.1 InterPro IPR005122; KEGG: azo:azo3976 uracil-DNA glycosylase; PFAM: Uracil-DNA glycosylase-like; SPTR: Probable uracil-DNA glycosylase; IMG reference gene:2503957283; PFAM: Uracil DNA glycosylase superfamily YP_004411584.1 COGs: COG1022 Long-chain acyl-CoA synthetase (AMP-forming); InterPro IPR000873; KEGG: ssm:Spirs_3134 AMP-dependent synthetase and ligase; PFAM: AMP-dependent synthetase/ligase; PRIAM: Long-chain-fatty-acid--CoA ligase; SPTR: long-chain-fatty-acid--CoA ligase; IMG reference gene:2503957284; PFAM: AMP-binding enzyme YP_004411585.1 COGs: COG0402 Cytosine deaminase and related metal-dependent hydrolase; InterPro IPR006680; KEGG: ssm:Spirs_1424 amidohydrolase; PFAM: Amidohydrolase 1; PRIAM: S-adenosylhomocysteine deaminase; SPTR: Amidohydrolase; IMG reference gene:2503957285; PFAM: Amidohydrolase YP_004411586.1 COGs: COG0162 Tyrosyl-tRNA synthetase; HAMAP: Tyrosyl-tRNA synthetase, class Ib; InterPro IPR002307:IPR002305; KEGG: ssm:Spirs_3153 tyrosyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class Ib; PRIAM: Tyrosine--tRNA ligase; SPTR: Tyrosyl-tRNA synthetase; TIGRFAM: Tyrosyl-tRNA synthetase, class Ib; IMG reference gene:2503957286; PFAM: tRNA synthetases class I (W and Y); TIGRFAM: tyrosyl-tRNA synthetase YP_004411587.1 COGs: COG0423 Glycyl-tRNA synthetase (class II); InterPro IPR002314:IPR004154:IPR002315; KEGG: ssm:Spirs_3154 glycyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain; Anticodon-binding; SPTR: Glycyl-tRNA synthetase; TIGRFAM: Glycyl-tRNA synthetase, alpha2 dimer; IMG reference gene:2503957287; PFAM: Anticodon binding domain; tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: glycyl-tRNA synthetase, dimeric type YP_004411588.1 COGs: COG0008 Glutamyl- and glutaminyl-tRNA synthetase; InterPro IPR020058:IPR004527; KEGG: ssm:Spirs_3155 glutamyl-tRNA synthetase; PFAM: Glutamyl/glutaminyl-tRNA synthetase, class Ic, catalytic domain; PRIAM: Glutamate--tRNA ligase; SPTR: Glutamyl-tRNA synthetase; TIGRFAM: Glutamyl-tRNA synthetase, class Ic, bacterial/mitochondrial; IMG reference gene:2503957288; PFAM: tRNA synthetases class I (E and Q), catalytic domain; TIGRFAM: glutamyl-tRNA synthetase, bacterial family YP_004411589.1 COGs: COG1647 Esterase/lipase; KEGG: pmo:Pmob_0119 carboxylesterase, SPTR: Carboxylesterase, ; IMG reference gene:2503957289 YP_004411590.1 COGs: COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; InterPro IPR000792; KEGG: bpo:BP951000_1223 two-component system regulator; PFAM: Transcription regulator LuxR, C-terminal; SMART: Transcription regulator LuxR, C-terminal; SPTR: Two-component system regulator; IMG reference gene:2503957290; PFAM: Bacterial regulatory proteins, luxR family YP_004411591.1 KEGG: lsp:Bsph_1275 abortive phage resistance protein, SPTR: Abortive phage resistance protein, ; IMG reference gene:2503957291 YP_004411592.1 KEGG: cyh:Cyan8802_0995 RloA protein; SPTR: RloA protein; IMG reference gene:2503957292 YP_004411593.1 KEGG: ssm:Spirs_0126 hypothetical protein; SPTR: Vacuolar protein sorting-associated protein 13 family protein; IMG reference gene:2503957293 YP_004411594.1 KEGG: bwe:BcerKBAB4_5427 ATPase; SPTR: Aspartic acid-rich protein aspolin2-2; IMG reference gene:2503957294 YP_004411595.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR013378; KEGG: aeh:Mlg_2687 regulator of chromosome condensation, RCC1; PFAM: Listeria/Bacterioides repeat; SPTR: Alpha-tubulin suppressor and related RCC1 domain-containing protein-like protein; IMG reference gene:2503957295; PFAM: Listeria-Bacteroides repeat domain (List_Bact_rpt); Regulator of chromosome condensation (RCC1) repeat YP_004411596.1 COGs: COG2984 ABC-type uncharacterized transport system periplasmic component; InterPro IPR007487; KEGG: gem:GM21_0736 protein of unknown function DUF534; PFAM: ABC transporter substrate binding protein; SPTR: uncharacterized protein; IMG reference gene:2503957297; PFAM: ABC transporter substrate binding protein YP_004411597.1 COGs: COG2984 ABC-type uncharacterized transport system periplasmic component; InterPro IPR007487; KEGG: dat:HRM2_37760 ABC-type transporter, periplasmic substrate binding protein; PFAM: ABC transporter substrate binding protein; SPTR: ABC-type transporter, periplasmic substrate binding protein; IMG reference gene:2503957298; PFAM: ABC transporter substrate binding protein YP_004411598.1 COGs: COG2984 ABC-type uncharacterized transport system periplasmic component; InterPro IPR007487; KEGG: gsu:GSU0210 hypothetical protein; PFAM: ABC transporter substrate binding protein; SPTR: uncharacterized protein; IMG reference gene:2503957299; PFAM: ABC transporter substrate binding protein YP_004411599.1 COGs: COG4120 ABC-type uncharacterized transport system permease component; InterPro IPR001851; KEGG: dat:HRM2_37770 ABC-type transporter, permease component; PFAM: ABC transporter permease; SPTR: ABC-type transporter, permease component; IMG reference gene:2503957300; PFAM: Branched-chain amino acid transport system / permease component YP_004411600.1 COGs: COG1101 ABC-type uncharacterized transport system ATPase component; InterPro IPR003439:IPR003593; KEGG: gbm:Gbem_0725 ABC transporter ATP-binding protein; PFAM: ABC transporter-like; PRIAM: Phosphonate-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter related protein; IMG reference gene:2503957301; PFAM: ABC transporter YP_004411601.1 COGs: COG0534 Na+-driven multidrug efflux pump; InterPro IPR002528; KEGG: cpy:Cphy_1252 MATE efflux family protein; PFAM: Multi antimicrobial extrusion protein; SPTR: efflux protein, MATE family; TIGRFAM: Multi antimicrobial extrusion protein; IMG reference gene:2503957302; PFAM: MatE; TIGRFAM: efflux protein, MATE family YP_004411602.1 COGs: COG0799 Iojap protein; InterPro IPR004394; KEGG: ssm:Spirs_1809 iojap-related protein; PFAM: Ribosome-associated, Iojap-like; SPTR: Iojap domain protein; TIGRFAM: Ribosome-associated, Iojap-like; IMG reference gene:2503957303; PFAM: Domain of unknown function DUF143; TIGRFAM: iojap-like ribosome-associated protein YP_004411603.1 KEGG: cpi:Cpin_5296 beta-ketoacyl synthase; SPTR: Central motor kinesin 1; IMG reference gene:2503957304 YP_004411604.1 COGs: COG1713 HD superfamily hydrolase involved in NAD metabolism; InterPro IPR006674; KEGG: rxy:Rxyl_2559 metal dependent phosphohydrolase; PFAM: Metal-dependent phosphohydrolase, HD subdomain; SPTR: Metal dependent phosphohydrolase; IMG reference gene:2503957305 YP_004411605.1 COGs: COG1057 Nicotinic acid mononucleotide adenylyltransferase; HAMAP: Probable nicotinate-nucleotide adenylyltransferase; InterPro IPR005248:IPR004820:IPR004821; KEGG: tpp:TPASS_0741 hypothetical protein; PFAM: Cytidylyltransferase; SPTR: Probable nicotinate-nucleotide adenylyltransferase; TIGRFAM: Probable nicotinate-nucleotide adenylyltransferase; Cytidyltransferase-related; IMG reference gene:2503957306; PFAM: Cytidylyltransferase; TIGRFAM: nicotinate (nicotinamide) nucleotide adenylyltransferase; cytidyltransferase-related domain YP_004411606.1 COGs: COG0536 GTPase; HAMAP: GTP-binding protein Obg/CgtA; InterPro IPR014100:IPR006169:IPR002917; KEGG: ssm:Spirs_1805 GTP-binding protein Obg/CgtA; PFAM: GTP1/OBG subdomain; GTP-binding protein, HSR1-related; SPTR: GTPase obg; TIGRFAM: GTP-binding protein Obg/CgtA; IMG reference gene:2503957307; PFAM: GTPase of unknown function; GTP1/OBG; TIGRFAM: Obg family GTPase CgtA YP_004411607.1 COGs: COG0211 Ribosomal protein L27; HAMAP: Ribosomal protein L27; InterPro IPR001684; KEGG: sta:STHERM_c10280 50S ribosomal protein L27; PFAM: Ribosomal protein L27; SPTR: 50S ribosomal protein L27; TIGRFAM: Ribosomal protein L27; IMG reference gene:2503957308; PFAM: Ribosomal L27 protein; TIGRFAM: ribosomal protein L27 YP_004411608.1 COGs: COG0261 Ribosomal protein L21; HAMAP: Ribosomal protein L21; InterPro IPR001787; KEGG: ssm:Spirs_1802 ribosomal protein L21; PFAM: Ribosomal protein L21; SPTR: 50S ribosomal protein L21; TIGRFAM: Ribosomal protein L21; IMG reference gene:2503957309; PFAM: Ribosomal prokaryotic L21 protein; TIGRFAM: ribosomal protein L21 YP_004411609.1 InterPro IPR001647; KEGG: mpd:MCP_0597 TetR family transcriptional regulator; PFAM: Transcription regulator, TetR-like, DNA-binding, bacterial/archaeal; SPTR: Transcriptional regulator; IMG reference gene:2503957310; PFAM: Bacterial regulatory proteins, tetR family YP_004411610.1 COGs: COG0018 Arginyl-tRNA synthetase; HAMAP: Arginyl-tRNA synthetase, class Ic; InterPro IPR001278:IPR005148:IPR015945:IPR008909; KEGG: ssm:Spirs_1801 arginyl-tRNA synthetase; PFAM: Arginyl-tRNA synthetase, class Ic, core; Arginyl tRNA synthetase, class Ic, N-terminal; DALR anticodon binding; PRIAM: Arginine--tRNA ligase; SMART: DALR anticodon binding; SPTR: uncharacterized protein; TIGRFAM: Arginyl-tRNA synthetase, class Ic; IMG reference gene:2503957311; PFAM: DALR anticodon binding domain; Arginyl tRNA synthetase N terminal domain; tRNA synthetases class I (R); TIGRFAM: arginyl-tRNA synthetase YP_004411611.1 COGs: COG0340 Biotin-(acetyl-CoA carboxylase) ligase; InterPro IPR013196:IPR004143:IPR004408; KEGG: cpy:Cphy_2779 biotin--acetyl-CoA-carboxylase ligase; PFAM: Biotin/lipoate A/B protein ligase; Helix-turn-helix, type 11; SPTR: Biotin--acetyl-CoA-carboxylase ligase; TIGRFAM: Biotin--acetyl-CoA-carboxylase ligase; IMG reference gene:2503957312; PFAM: HTH domain; Biotin/lipoate A/B protein ligase; TIGRFAM: BirA biotin operon repressor domain; birA, biotin-[acetyl-CoA-carboxylase] ligase region YP_004411612.1 COGs: COG1268 conserved hypothetical protein; InterPro IPR003784; KEGG: sta:STHERM_c14470 biotin synthesis protein BioY; PFAM: BioY protein; SPTR: Biotin synthesis protein BioY; IMG reference gene:2503957313; PFAM: BioY family YP_004411613.1 COGs: COG1045 Serine acetyltransferase; InterPro IPR001451; KEGG: ssm:Spirs_1684 serine O-acetyltransferase; PFAM: Bacterial transferase hexapeptide repeat; PRIAM: Serine O-acetyltransferase; SPTR: uncharacterized protein; IMG reference gene:2503957314; TIGRFAM: serine O-acetyltransferase YP_004411614.1 COGs: COG0621 2-methylthioadenine synthetase; InterProIPR013848:IPR007197:IPR005839:IPR006467:IPR 006638; KEGG: ssm:Spirs_1516 MiaB-like tRNA modifying enzyme; PFAM: Radical SAM; Methylthiotransferase, N-terminal; SMART: Elongator protein 3/MiaB/NifB; SPTR: uncharacterized protein; TIGRFAM: MiaB-like tRNA modifying enzyme; Methylthiotransferase; IMG reference gene:2503957315; PFAM: Radical SAM superfamily; Uncharacterized protein family UPF0004; TIGRFAM: MiaB-like tRNA modifying enzyme; radical SAM methylthiotransferase, MiaB/RimO family YP_004411615.1 COGs: COG0287 Prephenate dehydrogenase; InterPro IPR003099; KEGG: ssm:Spirs_1513 prephenate dehydrogenase; PFAM: Prephenate dehydrogenase; SPTR: Arogenate dehydrogenase 2; IMG reference gene:2503957316; PFAM: Prephenate dehydrogenase YP_004411616.1 COGs: COG0280 Phosphotransacetylase; InterPro IPR002505:IPR004614; KEGG: ssm:Spirs_1512 phosphate acetyltransferase; PFAM: Phosphate acetyl/butaryl transferase; PRIAM: Phosphate acetyltransferase; SPTR: Phosphate acetyltransferase; TIGRFAM: Phosphate acetyltransferase; IMG reference gene:2503957317; PFAM: Phosphate acetyl/butaryl transferase; TIGRFAM: phosphate acetyltransferase YP_004411617.1 COGs: COG0534 Na+-driven multidrug efflux pump; InterPro IPR002528; KEGG: cac:CA_C3444 cation efflux pump (multidrug resistance protein); PFAM: Multi antimicrobial extrusion protein; SPTR: uncharacterized protein; TIGRFAM: Multi antimicrobial extrusion protein; IMG reference gene:2503957318; PFAM: MatE; TIGRFAM: efflux protein, MATE family YP_004411618.1 COGs: COG0030 Dimethyladenosine transferase (rRNA methylation); HAMAP: Ribosomal RNA adenine dimethylase; InterPro IPR011530:IPR001737:IPR020598; KEGG: tde:TDE1080 dimethyladenosine transferase; PFAM: Ribosomal RNA adenine methylase transferase; SMART: Ribosomal RNA adenine methylase transferase, N-terminal; SPTR: Ribosomal RNA small subunit methyltransferase A; TIGRFAM: Ribosomal RNA adenine dimethylase; IMG reference gene:2503957319; PFAM: Ribosomal RNA adenine dimethylase; TIGRFAM: dimethyladenosine transferase YP_004411619.1 KEGG: mcc:698537 one cut homeobox 2; SPTR: uncharacterized protein; manually curated; IMG reference gene:2503957321 YP_004411620.1 KEGG: ssm:Spirs_1495 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957322 YP_004411621.1 COGs: COG1109 Phosphomannomutase; InterPro IPR005844:IPR005845; KEGG: sta:STHERM_c11950 hypothetical protein; PFAM: Alpha-D-phosphohexomutase, alpha/beta/alpha domain I; Alpha-D-phosphohexomutase, alpha/beta/alpha domain II; SPTR: uncharacterized protein; IMG reference gene:2503957323; PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosphoglucomutase/phosphomannomutase, C-terminal domain; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I YP_004411622.1 COGs: COG0546 phosphatase; InterPro IPR005834; KEGG: apv:Apar_0414 HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase-like hydrolase; PRIAM: Phosphoglycolate phosphatase; SPTR: Phosphoglycolate phosphatase; IMG reference gene:2503957324; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: 2-phosphoglycolate phosphatase, prokaryotic YP_004411623.1 COGs: COG1092 SAM-dependent methyltransferase; KEGG: phe:Phep_4225 PUA domain containing protein; SPTR: PUA domain containing protein; IMG reference gene:2503957325; PFAM: S-adenosylmethionine-dependent methyltransferase YP_004411624.1 InterPro IPR005358; KEGG: tde:TDE0847 hypothetical protein; PFAM: Uncharacterised protein family UPF0153; SPTR: uncharacterized protein; IMG reference gene:2503957326; PFAM: Uncharacterised protein family (UPF0153) YP_004411625.1 COGs: COG0598 Mg2+ and Co2+ transporter; InterPro IPR002523; KEGG: cce:Ccel_2001 Mg2 transporter protein CorA family protein; PFAM: Mg2+ transporter protein, CorA-like; SPTR: Mg2 transporter protein CorA family protein; IMG reference gene:2503957327; PFAM: CorA-like Mg2+ transporter protein YP_004411626.1 COGs: COG2316 hydrolase (HD superfamily); InterPro IPR006674:IPR006675; KEGG: ttm:Tthe_2220 metal dependent phosphohydrolase; PFAM: Metal-dependent phosphohydrolase, HD subdomain; SPTR: Metal dependent phosphohydrolase; TIGRFAM: Uncharacterised protein family HDIG; IMG reference gene:2503957328; PFAM: HD domain; TIGRFAM: uncharacterized domain HDIG YP_004411627.1 KEGG: hmg:100201846 similar to predicted protein; IMG reference gene:2503957329 YP_004411628.1 IMG reference gene:2503957330 YP_004411629.1 COGs: COG0044 Dihydroorotase and related cyclic amidohydrolase; KEGG: tde:TDE2107 dihydroorotase, SPTR: Dihydroorotase, ; IMG reference gene:2503957331 YP_004411630.1 COGs: COG0167 Dihydroorotate dehydrogenase; InterPro IPR012135:IPR008333:IPR001433:IPR005720; KEGG: tde:TDE0982 dihydroorotate dehydrogenase/oxidoreductase, FAD-binding; PFAM: Dihydroorotate dehydrogenase, class 1/ 2; Oxidoreductase, FAD-binding domain; Oxidoreductase FAD/NAD(P)-binding; SPTR: Dihydroorotate dehydrogenase/oxidoreductase, FAD-binding; TIGRFAM: Dihydroorotate dehydrogenase, class 1; IMG reference gene:2503957332; PFAM: Dihydroorotate dehydrogenase; TIGRFAM: dihydroorotate dehydrogenase (subfamily 1) family protein YP_004411631.1 COGs: COG0284 Orotidine-5'-phosphate decarboxylase; InterPro IPR001754:IPR011995; KEGG: ssm:Spirs_1435 orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase domain; PRIAM: Orotidine-5'-phosphate decarboxylase; SMART: Orotidine 5'-phosphate decarboxylase domain; SPTR: Orotidine 5'-phosphate decarboxylase; TIGRFAM: Orotidine 5'-phosphate decarboxylase, type 2; IMG reference gene:2503957333; PFAM: Orotidine 5'-phosphate decarboxylase / HUMPS family; TIGRFAM: orotidine 5'-phosphate decarboxylase, subfamily 2 YP_004411632.1 COGs: COG0461 Orotate phosphoribosyltransferase; InterPro IPR000836:IPR004467; KEGG: tde:TDE1001 orotate phosphoribosyltransferase; PFAM: Phosphoribosyltransferase; SPTR: Orotate phosphoribosyltransferase; TIGRFAM: Orotate phosphoribosyl transferase, clade 1; IMG reference gene:2503957334; PFAM: Phosphoribosyl transferase domain; TIGRFAM: orotate phosphoribosyltransferase YP_004411633.1 COGs: COG0540 Aspartate carbamoyltransferase catalytic chain; InterPro IPR006132:IPR006131:IPR002082; KEGG: tde:TDE0129 bifunctional aspartate carbamoyltransferase catalytic subunit/aspartate carbamoyltransferase regulatory subunit; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain; PRIAM: Aspartate carbamoyltransferase; SPTR: Protein pyrBI; TIGRFAM: Aspartate carbamoyltransferase, eukaryotic; IMG reference gene:2503957335; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Aspartate carbamoyltransferase regulatory chain, metal binding domain; Aspartate carbamoyltransferase regulatory chain, allosteric domain; TIGRFAM: aspartate carbamoyltransferase YP_004411634.1 COGs: COG2606 conserved hypothetical protein; InterPro IPR007214:IPR004369; KEGG: ssm:Spirs_3308 YbaK/EbsC protein; PFAM: YbaK/aminoacyl-tRNA synthetase-associated domain; SPTR: YbaK/ebsC protein; TIGRFAM: Prolyl-tRNA editing protein, YbaK/EbsC; IMG reference gene:2503957336; PFAM: YbaK / prolyl-tRNA synthetases associated domain; TIGRFAM: ybaK/ebsC protein YP_004411635.1 COGs: COG0546 phosphatase; InterPro IPR005834:IPR006439; KEGG: rha:RHA1_ro01185 phosphoglycolate phosphatase; PFAM: Haloacid dehalogenase-like hydrolase; SPTR: Phosphoglycolate phosphatase; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 1; IMG reference gene:2503957337; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E YP_004411636.1 KEGG: ank:AnaeK_1538 sec-C motif domain protein; SPTR: SEC-C motif domain protein; IMG reference gene:2503957339 YP_004411637.1 COGs: COG3467 flavin-nucleotide-binding protein; InterPro IPR011576; KEGG: ctc:CTC00899 5-nitroimidazole antibiotic resistance protein; PFAM: Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain; SPTR: Predicted flavin-nucleotide-binding protein; IMG reference gene:2503957340; PFAM: Pyridoxamine 5'-phosphate oxidase YP_004411638.1 COGs: COG4277 DNA-binding protein with the Helix-hairpin-helix motif; InterPro IPR007197; KEGG: tjr:TherJR_1012 radical SAM domain protein; PFAM: Radical SAM; SPTR: Helix-hairpin-helix motif protein; IMG reference gene:2503957341 YP_004411639.1 COGs: COG0432 conserved hypothetical protein; InterPro IPR001602; KEGG: chy:CHY_0024 hypothetical protein; PFAM: Uncharacterised protein family UPF0047; SPTR: uncharacterized protein; TIGRFAM: Uncharacterised protein family UPF0047; IMG reference gene:2503957342; PFAM: Uncharacterised protein family UPF0047; TIGRFAM: secondary thiamine-phosphate synthase enzyme YP_004411640.1 COGs: COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems permease components; InterPro IPR001851; KEGG: gka:GK1893 sugar ABC transporter (permease); PFAM: ABC transporter permease; SPTR: Monosaccharide-transporting ATPase; IMG reference gene:2503957343; PFAM: Branched-chain amino acid transport system / permease component YP_004411641.1 COGs: COG1129 ABC-type sugar transport system ATPase component; InterPro IPR003439:IPR003593; KEGG: str:Sterm_4010 ABC transporter related protein; PFAM: ABC transporter-like; PRIAM: Monosaccharide-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter related protein; IMG reference gene:2503957344; PFAM: ABC transporter YP_004411642.1 COGs: COG1879 ABC-type sugar transport system periplasmic component; KEGG: gka:GK1896 sugar ABC transporter (sugar-binding protein); SPTR: Periplasmic binding protein/LacI transcriptional regulator; IMG reference gene:2503957345; PFAM: family YP_004411643.1 COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR001509; KEGG: rca:Rcas_0181 NAD-dependent epimerase/dehydratase; PFAM: NAD-dependent epimerase/dehydratase; SPTR: NAD-dependent epimerase/dehydratase; IMG reference gene:2503957346; PFAM: NAD dependent epimerase/dehydratase YP_004411644.1 COGs: COG2186 Transcriptional regulators; InterPro IPR000524:IPR011711; KEGG: rxy:Rxyl_0539 GntR family transcriptional regulator; PFAM: GntR, C-terminal; HTH transcriptional regulator, GntR; SMART: GntR, C-terminal; HTH transcriptional regulator, GntR; SPTR: GntR domain protein; IMG reference gene:2503957347; PFAM: Bacterial regulatory proteins, gntR family; FCD domain YP_004411645.1 COGs: COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase); InterPro IPR002198; KEGG: pjd:Pjdr2_0308 short-chain dehydrogenase/reductase SDR; PFAM: Short-chain dehydrogenase/reductase SDR; PRIAM: 3-oxoacyl-[acyl-carrier-protein] reductase; SPTR: Short-chain dehydrogenase/reductase SDR; IMG reference gene:2503957348; PFAM: short chain dehydrogenase YP_004411646.1 COGs: COG3246 conserved hypothetical protein; InterPro IPR008567; KEGG: sth:STH64 hypothetical protein; PFAM: Protein of unknown function DUF849, prokaryotic; SPTR: uncharacterized protein; IMG reference gene:2503957349; PFAM: Prokaryotic protein of unknown function (DUF849) YP_004411647.1 COGs: COG0673 dehydrogenase and related protein; InterPro IPR000683:IPR004104:IPR000587:IPR000994; KEGG: csh:Closa_3838 oxidoreductase domain protein; PFAM: Oxidoreductase, N-terminal; Oxidoreductase, C-terminal; Creatinase; Peptidase M24, structural domain; SPTR: Oxidoreductase domain protein; IMG reference gene:2503957350; PFAM: Oxidoreductase, NAD-binding Rossmann fold; Oxidoreductase, C-terminal alpha/beta domain; Metallopeptidase M24; Creatinase/Prolidase N-terminal domain YP_004411648.1 COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR004839; KEGG: aco:Amico_0368 aminotransferase class I and II; PFAM: Aminotransferase, class I/classII; PRIAM: Aspartate transaminase; SPTR: alanine transaminase (Class-I pyridoxal-phosphate-dependent aminotransferase) (AlaT/patA-like); IMG reference gene:2503957351; PFAM: Aminotransferase class I and II YP_004411649.1 COGs: COG0462 Phosphoribosylpyrophosphate synthetase; InterPro IPR000836:IPR005946; KEGG: ssm:Spirs_0557 ribose-phosphate pyrophosphokinase; PFAM: Phosphoribosyltransferase; PRIAM: Ribose-phosphate diphosphokinase; SPTR: Phosphoribosylpyrophosphate synthetase; TIGRFAM: Phosphoribosyl pyrophosphokinase; IMG reference gene:2503957352; PFAM: Phosphoribosyl transferase domain; TIGRFAM: ribose-phosphate pyrophosphokinase YP_004411650.1 COGs: COG0395 ABC-type sugar transport system permease component; InterPro IPR000515; KEGG: thx:Thet_2162 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: uncharacterized protein; IMG reference gene:2503957353; PFAM: Binding-protein-dependent transport system inner membrane component YP_004411651.1 COGs: COG1175 ABC-type sugar transport systems permease components; InterPro IPR000515; KEGG: tle:Tlet_1227 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: uncharacterized protein; IMG reference gene:2503957354; PFAM: Binding-protein-dependent transport system inner membrane component YP_004411652.1 COGs: COG1653 ABC-type sugar transport system periplasmic component; InterPro IPR006059; KEGG: tpd:Teth39_0261 extracellular solute-binding protein; PFAM: Bacterial extracellular solute-binding, family 1; SPTR: uncharacterized protein; IMG reference gene:2503957355; PFAM: Bacterial extracellular solute-binding protein YP_004411653.1 COGs: COG0366 Glycosidase; InterPro IPR004185:IPR006047:IPR006589; KEGG: bse:Bsel_1069 alpha amylase catalytic region; PFAM: Glycosyl hydrolase, family 13, catalytic domain; Glycoside hydrolase, family 13, N-terminal Ig-like domain; PRIAM: Cyclomaltodextrinase; SMART: Glycosyl hydrolase, family 13, subfamily, catalytic domain; SPTR: uncharacterized protein; IMG reference gene:2503957356; PFAM: Alpha amylase, N-terminal ig-like domain; Alpha amylase, catalytic domain YP_004411654.1 COGs: COG1609 Transcriptional regulators; InterPro IPR000843:IPR001761; KEGG: afl:Aflv_2186 transcriptional regulator, LacI family (HTH and periplasmic-binding domains); PFAM: Periplasmic binding protein/LacI transcriptional regulator; HTH transcriptional regulator, LacI; SMART: HTH transcriptional regulator, LacI; SPTR: Transcriptional regulator, LacI family; IMG reference gene:2503957357; PFAM: Bacterial regulatory proteins, lacI family; family YP_004411655.1 COGs: COG0165 Argininosuccinate lyase; InterPro IPR022761:IPR009049; KEGG: ssm:Spirs_3701 argininosuccinate lyase; PFAM: Lyase 1, N-terminal; PRIAM: Argininosuccinate lyase; SPTR: Argininosuccinate lyase; TIGRFAM: Argininosuccinate lyase; IMG reference gene:2503957358; PFAM: Lyase; TIGRFAM: argininosuccinate lyase YP_004411656.1 KEGG: sta:STHERM_c01870 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957359 YP_004411657.1 COGs: COG3118 Thioredoxin domain-containing protein; InterPro IPR013766:IPR005746; KEGG: sta:STHERM_c01860 thioredoxin; PFAM: Thioredoxin domain; SPTR: Thioredoxin; TIGRFAM: Thioredoxin; IMG reference gene:2503957360; PFAM: Thioredoxin; TIGRFAM: thioredoxin YP_004411658.1 COGs: COG0629 Single-stranded DNA-binding protein; InterPro IPR000424:IPR011344; KEGG: ssm:Spirs_3718 single-strand binding protein; PFAM: Primosome PriB/single-strand DNA-binding; SPTR: Single-stranded DNA-binding protein; TIGRFAM: Single-strand DNA-binding; IMG reference gene:2503957361; PFAM: Single-strand binding protein family; TIGRFAM: single stranded DNA-binding protein (ssb) YP_004411659.1 COGs: COG0528 Uridylate kinase; InterPro IPR001048:IPR011818; KEGG: tde:TDE2085 uridylate kinase; PFAM: Aspartate/glutamate/uridylate kinase; SPTR: Amino acid kinase; TIGRFAM: Uridylate kinase, archaeal/spirochete, IMG reference gene:2503957362; PFAM: Amino acid kinase; TIGRFAM: uridylate kinase YP_004411660.1 COGs: COG1313 Uncharacterized Fe-S protein PflX homolog of pyruvate formate lyase activating protein; InterPro IPR007197; KEGG: ssm:Spirs_3763 radical SAM domain protein; PFAM: Radical SAM; SPTR: Radical SAM domain protein; IMG reference gene:2503957363 YP_004411661.1 COGs: COG3621 Patatin; InterPro IPR002641; KEGG: ssm:Spirs_0041 patatin; PFAM: Patatin/Phospholipase A2-related; SPTR: Patatin family protein; IMG reference gene:2503957364; PFAM: Patatin-like phospholipase YP_004411662.1 COGs: COG2240 Pyridoxal/pyridoxine/pyridoxamine kinase; InterPro IPR013749; KEGG: hor:Hore_04110 pyridoxamine kinase; PFAM: Phosphomethylpyrimidine kinase type-1; SPTR: Pyridoxal kinase; IMG reference gene:2503957365; PFAM: Phosphomethylpyrimidine kinase YP_004411663.1 COGs: COG1109 Phosphomannomutase; InterPro IPR005844; KEGG: ssm:Spirs_2289 phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; PFAM: Alpha-D-phosphohexomutase, alpha/beta/alpha domain I; SPTR: uncharacterized protein; IMG reference gene:2503957366; PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I YP_004411664.1 COGs: COG5026 Hexokinase; InterPro IPR022672:IPR022673; KEGG: ssm:Spirs_3985 hexokinase; PFAM: Hexokinase, C-terminal; Hexokinase, N-terminal; PRIAM: Hexokinase; SPTR: uncharacterized protein; IMG reference gene:2503957367; PFAM: Hexokinase YP_004411665.1 COGs: COG2925 Exonuclease I; InterPro IPR013520:IPR013620:IPR006055; KEGG: ssm:Spirs_3051 exodeoxyribonuclease I; PFAM: Exonuclease C-terminal; Exonuclease, RNase T/DNA polymerase III; PRIAM: Exodeoxyribonuclease I; SMART: Exonuclease; SPTR: Exodeoxyribonuclease I subunit C; IMG reference gene:2503957368; PFAM: Exonuclease; Exonuclease C-terminal YP_004411666.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR011110:IPR000408; KEGG: aeh:Mlg_2687 regulator of chromosome condensation, RCC1; PFAM: Regulator of chromosome condensation, RCC1; Two component regulator propeller; SPTR: uncharacterized protein; IMG reference gene:2503957369; PFAM: Regulator of chromosome condensation (RCC1) repeat YP_004411667.1 COGs: COG0156 7-keto-8-aminopelargonate synthetase; InterPro IPR004839:IPR011282; KEGG: sro:Sros_8853 glycine C-acetyltransferase; PFAM: Aminotransferase, class I/classII; PRIAM: Glycine C-acetyltransferase; SPTR: Glycine C-acetyltransferase; TIGRFAM: 2-amino-3-ketobutyrate coenzyme A ligase; IMG reference gene:2503957370; PFAM: Aminotransferase class I and II; TIGRFAM: 8-amino-7-oxononanoate synthase; 2-amino-3-ketobutyrate coenzyme A ligase YP_004411668.1 COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR001509; KEGG: bmd:BMD_1541 NAD dependent epimerase/dehydratase; PFAM: NAD-dependent epimerase/dehydratase; PRIAM: L-threonine 3-dehydrogenase; SPTR: NAD-dependent epimerase; possible UDP-glucose 4-epimerase; IMG reference gene:2503957371; PFAM: NAD dependent epimerase/dehydratase YP_004411669.1 InterPro IPR001387:IPR013096; KEGG: ssm:Spirs_2303 transcriptional regulator, XRE family; PFAM: Helix-turn-helix type 3; Cupin 2, conserved barrel; SMART: Helix-turn-helix type 3; SPTR: Transcriptional regulator, XRE family; IMG reference gene:2503957372; PFAM: Cupin domain; Helix-turn-helix YP_004411670.1 COGs: COG2211 Na+/melibiose symporter and related transporter; InterPro IPR011701; KEGG: tth:TT_P0219 hypothetical protein; PFAM: Major facilitator superfamily MFS-1; SPTR: Predicted protein; IMG reference gene:2503957373; PFAM: Major Facilitator Superfamily YP_004411671.1 COGs: COG3345 Alpha-galactosidase; InterPro IPR000111; KEGG: ere:EUBREC_0489 alpha-galactosidase; PFAM: Glycoside hydrolase, clan GH-D; PRIAM: Alpha-galactosidase; SPTR: uncharacterized protein; IMG reference gene:2503957374; PFAM: Melibiase YP_004411672.1 InterPro IPR019563; KEGG: hje:HacjB3_16901 glycoside hydrolase 97; PFAM: Glycoside hydrolase, family 97; SPTR: Alpha-glucosidase; IMG reference gene:2503957375; PFAM: Glycoside hydrolase 97 YP_004411673.1 COGs: COG0395 ABC-type sugar transport system permease component; InterPro IPR000515; KEGG: cce:Ccel_1254 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Binding-protein-dependent transport systems inner membrane component; IMG reference gene:2503957376; PFAM: Binding-protein-dependent transport system inner membrane component YP_004411674.1 COGs: COG4209 ABC-type polysaccharide transport system permease component; InterPro IPR000515; KEGG: gym:GYMC10_4465 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Binding-protein-dependent transport systems inner membrane component; IMG reference gene:2503957377; PFAM: Binding-protein-dependent transport system inner membrane component YP_004411675.1 COGs: COG1653 ABC-type sugar transport system periplasmic component; InterPro IPR006059; KEGG: cce:Ccel_1252 extracellular solute-binding protein family 1; PFAM: Bacterial extracellular solute-binding, family 1; SPTR: Extracellular solute-binding protein family 1; IMG reference gene:2503957378; PFAM: Bacterial extracellular solute-binding protein YP_004411676.1 COGs: COG2207 AraC-type DNA-binding domain-containing protein; InterPro IPR000005:IPR018060; KEGG: ppp:PHYPADRAFT_103760 hypothetical protein; PFAM: HTH transcriptional regulator, AraC; SMART: Helix-turn-helix, AraC type, DNA binding domain; SPTR: Predicted protein; IMG reference gene:2503957379; PFAM: Bacterial regulatory helix-turn-helix proteins, AraC family YP_004411677.1 COGs: COG0216 Protein chain release factor A; HAMAP: Peptide chain release factor 1; InterPro IPR004373:IPR005139:IPR000352; KEGG: tde:TDE2489 peptide chain release factor 1; PFAM: Peptide chain release factor class I/class II; Peptide chain release factor; SMART: Peptide chain release factor; SPTR: Peptide chain release factor 1; TIGRFAM: Peptide chain release factor 1; IMG reference gene:2503957380; PFAM: PCRF domain; RF-1 domain; TIGRFAM: peptide chain release factor 1 YP_004411678.1 COGs: COG2890 Methylase of polypeptide chain release factors; InterPro IPR007848:IPR004556:IPR019874; KEGG: dsy:DSY4933 hypothetical protein; PFAM: Methyltransferase small; PRIAM: Site-specific DNA-methyltransferase (adenine-specific); SPTR: Methylase of polypeptide chain release factors; TIGRFAM: Protein-(glutamine-N5) methyltransferase, release factor-specific; Modification methylase HemK; IMG reference gene:2503957381; PFAM: Methyltransferase small domain; TIGRFAM: HemK family methylases; protein-(glutamine-N5) methyltransferase, release factor-specific YP_004411679.1 COGs: COG0317 Guanosine polyphosphate pyrophosphohydrolase/synthetase; InterProIPR006674:IPR007685:IPR004095:IPR004811:IPR 003607; KEGG: ssm:Spirs_3047 (p)ppGpp synthetase I, SpoT/RelA; PFAM: RelA/SpoT; Metal-dependent phosphohydrolase, HD subdomain; TGS; PRIAM: GTP diphosphokinase; SMART: RelA/SpoT; Metal-dependent phosphohydrolase, HD domain; SPTR: Probable GTP pyrophosphokinase; TIGRFAM: RelA/SpoT protein; IMG reference gene:2503957382; PFAM: HD domain; TGS domain; Region found in RelA / SpoT proteins; TIGRFAM: (p)ppGpp synthetase, RelA/SpoT family YP_004411680.1 COGs: COG0698 Ribose 5-phosphate isomerase RpiB; InterPro IPR003500; KEGG: ssm:Spirs_2662 sugar-phosphate isomerase, RpiB/LacA/LacB family; PFAM: Ribose/galactose isomerase; PRIAM: Ribose-5-phosphate isomerase; SPTR: Ribose 5-phosphate isomerase B; TIGRFAM: Ribose/galactose isomerase; IMG reference gene:2503957383; PFAM: Ribose/Galactose Isomerase; TIGRFAM: sugar-phosphate isomerases, RpiB/LacA/LacB family YP_004411681.1 KEGG: asc:ASAC_1319 dehydrogenase; SPTR: Aquaporin Z; manually curated; IMG reference gene:2503957384 YP_004411682.1 KEGG: ppp:PHYPADRAFT_84532 Rb -related protein; SPTR: Retinoblastoma-related protein; IMG reference gene:2503957385 YP_004411683.1 COGs: COG1502 Phosphatidylserine/phosphatidylglycerophosphate/ cardiolipin synthase; InterPro IPR001736; KEGG: dal:Dalk_3445 phospholipase D/transphosphatidylase; PFAM: Phospholipase D/Transphosphatidylase; SMART: Phospholipase D/Transphosphatidylase; SPTR: Cardiolipin synthetase; IMG reference gene:2503957386; PFAM: Phospholipase D Active site motif YP_004411684.1 COGs: COG0295 Cytidine deaminase; InterPro IPR005834:IPR002125:IPR006402:IPR006262; KEGG: ssm:Spirs_2666 cytidine deaminase; PFAM: Haloacid dehalogenase-like hydrolase; CMP/dCMP deaminase, zinc-binding; SPTR: uncharacterized protein; TIGRFAM: Cytidine deaminase, homotetrameric; HAD-superfamily hydrolase, subfamily IA, variant 3; IMG reference gene:2503957387; PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region; haloacid dehalogenase-like hydrolase; TIGRFAM: haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; cytidine deaminase, homotetrameric YP_004411685.1 COGs: COG0112 Glycine/serine hydroxymethyltransferase; InterPro IPR001085; KEGG: ssm:Spirs_2146 glycine hydroxymethyltransferase; PFAM: Serine hydroxymethyltransferase; PRIAM: Glycine hydroxymethyltransferase; SPTR: Serine hydroxymethyltransferase; IMG reference gene:2503957388; PFAM: Serine hydroxymethyltransferase YP_004411686.1 COGs: COG0361 Translation initiation factor 1 (IF-1); HAMAP: Translation initiation factor IF-1; InterPro IPR004368:IPR006196:IPR022967; KEGG: sta:STHERM_c16730 translation initiation factor IF-1 1; PFAM: RNA-binding domain, S1, IF1 type; SMART: RNA-binding domain, S1; SPTR: Translation initiation factor IF-1 1; TIGRFAM: Translation initiation factor IF-1; IMG reference gene:2503957389; PFAM: Translation initiation factor 1A / IF-1; TIGRFAM: translation initiation factor IF-1 YP_004411687.1 KEGG: scm:SCHCODRAFT_61185 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957390 YP_004411688.1 COGs: COG1893 Ketopantoate reductase; InterPro IPR013332:IPR013752:IPR003710; KEGG: pde:Pden_4530 2-dehydropantoate 2-reductase; PFAM: Ketopantoate reductase ApbA/PanE, C-terminal; Ketopantoate reductase ApbA/PanE, N-terminal; PRIAM: 2-dehydropantoate 2-reductase; SPTR: 2-dehydropantoate 2-reductase; TIGRFAM: Ketopantoate reductase ApbA/PanE; IMG reference gene:2503957391; PFAM: Ketopantoate reductase PanE/ApbA; Ketopantoate reductase PanE/ApbA C terminal; TIGRFAM: 2-dehydropantoate 2-reductase YP_004411689.1 COGs: COG2840 conserved hypothetical protein; InterPro IPR002625; KEGG: tde:TDE1254 Smr domain-containing protein; PFAM: Smr protein/MutS2 C-terminal; SMART: Smr protein/MutS2 C-terminal; SPTR: Smr domain protein; IMG reference gene:2503957392; PFAM: Smr domain YP_004411690.1 COGs: COG3448 CBS-domain-containing membrane protein; InterPro IPR000644:IPR002912; KEGG: ssm:Spirs_0348 signal transduction protein with CBS domains; PFAM: Cystathionine beta-synthase, core; Amino acid-binding ACT; SMART: Cystathionine beta-synthase, core; SPTR: CBS domain containing protein; IMG reference gene:2503957393; PFAM: CBS domain YP_004411691.1 COGs: COG0410 ABC-type branched-chain amino acid transport systems ATPase component; InterPro IPR003439:IPR003593; KEGG: ssm:Spirs_0347 ABC transporter related protein; PFAM: ABC transporter-like; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter related protein; IMG reference gene:2503957394; PFAM: ABC transporter YP_004411692.1 COGs: COG0411 ABC-type branched-chain amino acid transport systems ATPase component; InterPro IPR003439:IPR003593; KEGG: ddf:DEFDS_0657 branched-chain amino acid ABC transporter ATP-binding protein; PFAM: ABC transporter-like; PRIAM: Monosaccharide-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: Branched-chain amino acid ABC transporter, ATP-binding protein; IMG reference gene:2503957395; PFAM: ABC transporter; Branched-chain amino acid ATP-binding cassette transporter YP_004411693.1 COGs: COG4177 ABC-type branched-chain amino acid transport system permease component; InterPro IPR001851; KEGG: dvl:Dvul_2395 inner-membrane translocator; PFAM: ABC transporter permease; SPTR: High-affinity branched-chain amino acid ABC transporter, permease; IMG reference gene:2503957396; PFAM: Branched-chain amino acid transport system / permease component YP_004411694.1 COGs: COG0559 Branched-chain amino acid ABC-type transport system permease components; InterPro IPR001851; KEGG: smc:SmuNN2025_0449 branched chain amino acid ABC transporter permease; PFAM: ABC transporter permease; SPTR: branched chain amino acid ABC transporter, permease; IMG reference gene:2503957397; PFAM: Branched-chain amino acid transport system / permease component YP_004411695.1 COGs: COG0683 ABC-type branched-chain amino acid transport systems periplasmic component; InterPro IPR001828; KEGG: dtu:Dtur_0932 extracellular ligand-binding receptor; PFAM: Extracellular ligand-binding receptor; SPTR: Extracellular ligand-binding receptor; IMG reference gene:2503957398; PFAM: Receptor family ligand binding region YP_004411696.1 COGs: COG3541 nucleotidyltransferase; InterPro IPR018775; KEGG: lic:LIC12213 hypothetical protein; PFAM: Nucleotidyltransferase, predicted; SPTR: uncharacterized protein; IMG reference gene:2503957399; PFAM: Predicted nucleotidyltransferase YP_004411697.1 COGs: COG0778 Nitroreductase; InterPro IPR000415; KEGG: spv:SPH_1818 nitroreductase; PFAM: Nitroreductase-like; SPTR: Nitroreductase; IMG reference gene:2503957401; PFAM: Nitroreductase YP_004411698.1 KEGG: rno:361605 PCF11, cleavage and polyadenylation factor subunit, homolog (S. cerevisiae); SPTR: uncharacterized protein; IMG reference gene:2503957402 YP_004411699.1 COGs: COG0550 Topoisomerase IA; InterProIPR006171:IPR013497:IPR005733:IPR003601:IPR 003602; KEGG: ssm:Spirs_0893 DNA topoisomerase I; PFAM: DNA topoisomerase, type IA, central; Toprim domain; PRIAM: DNA topoisomerase; SMART: DNA topoisomerase, type IA, DNA-binding; DNA topoisomerase, type IA, domain 2; Toprim domain; SPTR: DNA topoisomerase; TIGRFAM: DNA topoisomerase I, bacterial-type; IMG reference gene:2503957403; PFAM: Toprim domain; DNA topoisomerase; TIGRFAM: DNA topoisomerase I, bacterial YP_004411700.1 KEGG: ssm:Spirs_3916 hypothetical protein; SPTR: Extracellular solute-binding protein family 5; IMG reference gene:2503957404 YP_004411701.1 COGs: COG0012 GTPase probable translation factor; InterPro IPR002917:IPR013029:IPR004396; KEGG: ssm:Spirs_3050 GTP-binding protein YchF; PFAM: Domain of unknown function DUF933; GTP-binding protein, HSR1-related; SPTR: GTP-binding protein YchF; TIGRFAM: Conserved hypothetical protein CHP00092; IMG reference gene:2503957405; PFAM: GTPase of unknown function; Protein of unknown function (DUF933); TIGRFAM: GTP-binding protein YchF YP_004411702.1 COGs: COG2262 GTPase; InterPro IPR002917:IPR016496; KEGG: ssm:Spirs_3087 GTP-binding protein HflX; PFAM: GTP-binding protein, HSR1-related; SPTR: GTPase; TIGRFAM: GTP-binding protein, HflX; IMG reference gene:2503957406; PFAM: GTPase of unknown function; TIGRFAM: GTP-binding protein HflX YP_004411703.1 KEGG: pmo:Pmob_1807 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957407 YP_004411704.1 COGs: COG1297 membrane protein; InterPro IPR004813; KEGG: cce:Ccel_0706 oligopeptide transporters, OPT superfamily; PFAM: Oligopeptide transporter OPT superfamily; SPTR: Oligopeptide transporter, OPT superfamily; IMG reference gene:2503957408; PFAM: OPT oligopeptide transporter protein; TIGRFAM: oligopeptide transporter, OPT family YP_004411705.1 COGs: COG0820 Fe-S-cluster redox enzyme; InterPro IPR007197:IPR004383; KEGG: ssm:Spirs_3145 radical SAM enzyme, Cfr family; PFAM: Radical SAM; SPTR: Ribosomal RNA large subunit methyltransferase N; TIGRFAM: Ribosomal RNA large subunit methyltransferase RlmN; IMG reference gene:2503957409; PFAM: Radical SAM superfamily; TIGRFAM: 23S rRNA m2A2503 methyltransferase YP_004411706.1 COGs: COG0013 Alanyl-tRNA synthetase; InterPro IPR018164:IPR012947:IPR002318; KEGG: ssm:Spirs_3146 alanyl-tRNA synthetase; PFAM: Alanyl-tRNA synthetase, class IIc, N-terminal; Threonyl/alanyl tRNA synthetase, SAD; SMART: Threonyl/alanyl tRNA synthetase, SAD; SPTR: Alanyl-tRNA synthetase; TIGRFAM: Alanyl-tRNA synthetase, class IIc; IMG reference gene:2503957410; PFAM: Threonyl and Alanyl tRNA synthetase second additional domain; tRNA synthetases class II (A); TIGRFAM: alanine--tRNA ligase YP_004411707.1 COGs: COG0758 Rossmann fold nucleotide-binding protein involved in DNA uptake; InterPro IPR003488; KEGG: kko:Kkor_2616 DNA protecting protein DprA; PFAM: DNA recombination-mediator protein A; SPTR: uncharacterized protein; IMG reference gene:2503957411; PFAM: DNA recombination-mediator protein A; TIGRFAM: DNA protecting protein DprA YP_004411708.1 COGs: COG1335 Amidase related to nicotinamidase; KEGG: ele:Elen_0388 conserved hypothetical protein, amidase; SPTR: uncharacterized protein; IMG reference gene:2503957413; PFAM: Isochorismatase YP_004411709.1 COGs: COG1957 Inosine-uridine nucleoside N-ribohydrolase; InterPro IPR001910; KEGG: str:Sterm_3734 ribosylpyrimidine nucleosidase; PFAM: Inosine/uridine-preferring nucleoside hydrolase domain; PRIAM: Ribosylpyrimidine nucleosidase; SPTR: Ribosylpyrimidine nucleosidase; IMG reference gene:2503957414; PFAM: Inosine-uridine preferring nucleoside hydrolase YP_004411710.1 COGs: COG0778 Nitroreductase; InterPro IPR000415; KEGG: sdl:Sdel_1154 nitroreductase; PFAM: Nitroreductase-like; SPTR: Nitroreductase; IMG reference gene:2503957415; PFAM: Nitroreductase YP_004411711.1 COGs: COG0813 Purine-nucleoside phosphorylase; InterPro IPR000845; KEGG: csh:Closa_1682 purine nucleoside phosphorylase; PFAM: Nucleoside phosphorylase domain; PRIAM: Purine-nucleoside phosphorylase; SPTR: Purine nucleoside phosphorylase deoD-type; IMG reference gene:2503957416; PFAM: Phosphorylase superfamily; TIGRFAM: purine-nucleoside phosphorylase, family 1 (deoD) YP_004411712.1 COGs: COG1079 ABC-type transport system permease component; InterPro IPR001851; KEGG: amt:Amet_3583 inner-membrane translocator; PFAM: ABC transporter permease; SPTR: uncharacterized protein; IMG reference gene:2503957417; PFAM: Branched-chain amino acid transport system / permease component YP_004411713.1 COGs: COG4603 ABC-type uncharacterized transport system permease component; InterPro IPR001851; KEGG: sta:STHERM_c17730 permease; PFAM: ABC transporter permease; SPTR: Carbohydrate uptake 2 (CUT2) family, permease; IMG reference gene:2503957418; PFAM: Branched-chain amino acid transport system / permease component YP_004411714.1 COGs: COG3845 ABC-type uncharacterized transport systems ATPase components; InterPro IPR003439:IPR003593; KEGG: aoe:Clos_0964 ABC transporter related; PFAM: ABC transporter-like; PRIAM: Monosaccharide-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter related; IMG reference gene:2503957419; PFAM: ABC transporter YP_004411715.1 COGs: COG1744 Uncharacterized ABC-type transport system periplasmic component/surface lipoprotein; InterPro IPR003760; KEGG: sta:STHERM_c17750 membrane lipoprotein TmpC precursor; PFAM: Basic membrane lipoprotein; SPTR: uncharacterized protein; IMG reference gene:2503957420; PFAM: Basic membrane protein YP_004411716.1 COGs: COG1122 ABC-type cobalt transport system ATPase component; InterPro IPR003439:IPR003593; KEGG: sfu:Sfum_1750 cobalt ABC transporter, ATPase subunit; PFAM: ABC transporter-like; PRIAM: Fe(3+)-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: Cobalt ABC transporter, ATPase subunit; IMG reference gene:2503957421; PFAM: ABC transporter YP_004411717.1 COGs: COG0619 ABC-type cobalt transport system permease component CbiQ and related transporter; InterPro IPR003339; KEGG: dal:Dalk_0379 cobalt transport protein; PFAM: Cobalt transport protein; SPTR: Cobalt transport protein; IMG reference gene:2503957422; PFAM: Cobalt transport protein YP_004411718.1 COGs: COG0212 5-formyltetrahydrofolate cyclo-ligase; InterPro IPR002698; KEGG: bha:BH1417 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; SPTR: 5-formyltetrahydrofolate cyclo-ligase; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; IMG reference gene:2503957423; PFAM: 5-formyltetrahydrofolate cyclo-ligase; TIGRFAM: 5,10-methenyltetrahydrofolate synthetase YP_004411719.1 COGs: COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); KEGG: ssm:Spirs_1642 PTS IIA-like nitrogen-regulatory protein PtsN; SPTR: uncharacterized protein; IMG reference gene:2503957424; PFAM: Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 YP_004411720.1 COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR013027:IPR006004; KEGG: dap:Dacet_0223 glutamate synthase (NADPH), homotetrameric; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PRIAM: Glutamate synthase (NADPH); SPTR: Glutamate synthase (NADPH), homotetrameric; TIGRFAM: Glutamate synthase (NADPH), homotetrameric; IMG reference gene:2503957425; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: glutamate synthase (NADPH), homotetrameric YP_004411721.1 COGs: COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductase; InterPro IPR001433:IPR019480; KEGG: ssm:Spirs_1640 oxidoreductase FAD/NAD(P)-binding domain protein; PFAM: Oxidoreductase FAD/NAD(P)-binding; Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; SPTR: Ferredoxin--NADP; IMG reference gene:2503957426; PFAM: Oxidoreductase FAD-binding domain; Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B; Oxidoreductase NAD-binding domain YP_004411722.1 COGs: COG0071 Molecular chaperone (small heat shock protein); InterPro IPR002068; KEGG: rfe:RF_1004 small heat shock protein; PFAM: Heat shock protein Hsp20; SPTR: Small heat shock protein C2; IMG reference gene:2503957427; PFAM: Hsp20/alpha crystallin family YP_004411723.1 COGs: COG2207 AraC-type DNA-binding domain-containing protein; InterPro IPR000005:IPR018060; KEGG: csh:Closa_2870 transcriptional regulator, AraC family; PFAM: HTH transcriptional regulator, AraC; SMART: Helix-turn-helix, AraC type, DNA binding domain; SPTR: Transcriptional regulator, AraC family; IMG reference gene:2503957428; PFAM: Bacterial regulatory helix-turn-helix proteins, AraC family YP_004411724.1 COGs: COG4606 ABC-type enterochelin transport system permease component; InterPro IPR000522; KEGG: csh:Closa_2869 transport system permease; PFAM: ABC transporter permease; SPTR: Transport system permease; IMG reference gene:2503957429; PFAM: FecCD transport family YP_004411725.1 COGs: COG4605 ABC-type enterochelin transport system permease component; InterPro IPR000522; KEGG: csh:Closa_2868 transport system permease; PFAM: ABC transporter permease; SPTR: Transport system permease; IMG reference gene:2503957430; PFAM: FecCD transport family YP_004411726.1 COGs: COG4604 ABC-type enterochelin transport system ATPase component; InterPro IPR003439:IPR003593; KEGG: bcy:Bcer98_0361 ABC transporter-related protein; PFAM: ABC transporter-like; PRIAM: Iron-chelate-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter-related protein; IMG reference gene:2503957431; PFAM: ABC transporter YP_004411727.1 COGs: COG4607 ABC-type enterochelin transport system periplasmic component; InterPro IPR002491; KEGG: csh:Closa_2866 periplasmic binding protein; PFAM: Periplasmic binding protein; SPTR: Periplasmic binding protein; IMG reference gene:2503957432; PFAM: Periplasmic binding protein YP_004411728.1 COGs: COG1203 helicase; InterPro IPR001650:IPR006483:IPR006474:IPR014001; KEGG: paa:Paes_1419 CRISPR-associated helicase Cas3; PFAM: Helicase, C-terminal; SMART: Helicase, C-terminal; DEAD-like helicase, N-terminal; SPTR: CRISPR-associated helicase Cas3; TIGRFAM: Helicase Cas3, CRISPR-associated, core; CRISPR-associated HD domain; IMG reference gene:2503957433; PFAM: DEAD/DEAH box helicase; TIGRFAM: CRISPR-associated helicase Cas3; CRISPR-associated endonuclease Cas3-HD YP_004411729.1 InterPro IPR013381; KEGG: paa:Paes_1418 CRISPR-associated protein, CSE1 family; PFAM: CRISPR-associated protein Cse1; SPTR: CRISPR-associated protein, Cse1 family; TIGRFAM: CRISPR-associated protein Cse1; IMG reference gene:2503957434; PFAM: CRISPR-associated protein Cse1 (CRISPR_cse1); TIGRFAM: CRISPR type I-E/ECOLI-associated protein CasA/Cse1 YP_004411730.1 InterPro IPR013382; KEGG: dze:Dd1591_0910 CRISPR-associated protein, CSE2 family; PFAM: CRISPR-associated protein Cse2; SPTR: CRISPR-associated protein, Cse2 family; TIGRFAM: CRISPR-associated protein Cse2; IMG reference gene:2503957435; PFAM: CRISPR-associated protein Cse2 (CRISPR_cse2); TIGRFAM: CRISPR type I-E/ECOLI-associated protein CasB/Cse2 YP_004411731.1 InterPro IPR010179; KEGG: dal:Dalk_4936 CRISPR-associated protein, CSE3 family; PFAM: CRISPR-associated protein, CT1974; SPTR: CRISPR-associated protein, Cse3 family; TIGRFAM: CRISPR-associated protein, CT1974; IMG reference gene:2503957436; PFAM: CRISPR associated protein; TIGRFAM: CRISPR-associated protein Cas6/Cse3/CasE, subtype I-E/ECOLI YP_004411732.1 InterPro IPR010148; KEGG: dze:Dd1591_0908 CRISPR-associated protein, CSE4 family; PFAM: CRISPR-associated protein, CT1975; SPTR: CRISPR-associated protein, Cse4 family; TIGRFAM: CRISPR-associated protein, CT1975; IMG reference gene:2503957437; PFAM: CT1975-like protein; TIGRFAM: CRISPR-associated protein Cas7/Cse4/CasC, subtype I-E/ECOLI YP_004411733.1 InterPro IPR010147:IPR013422; KEGG: cpb:Cphamn1_2163 CRISPR-associated protein Cas5 family; SPTR: CRISPR-associated protein Cas5 family; TIGRFAM: CRISPR-associated protein, Cas5e-type; CRISPR-associated protein Cas5, N-terminal domain; IMG reference gene:2503957438; PFAM: CRISPR-associated protein (Cas_Cas5); TIGRFAM: CRISPR-associated protein Cas5/CasD, subtype I-E/ECOLI; CRISPR-associated protein Cas5, N-terminal domain YP_004411734.1 COGs: COG1518 Uncharacterized protein predicted to be involved in DNA repair; InterPro IPR002729:IPR019851; KEGG: dal:Dalk_4939 CRISPR-associated protein Cas1; PFAM: CRISPR-associated protein Cas1; SPTR: CRISPR-associated protein Cas1; TIGRFAM: CRISPR-associated protein Cas1, ECOLI subtype; CRISPR-associated protein Cas1; IMG reference gene:2503957439; PFAM: CRISPR associated protein Cas1; TIGRFAM: CRISPR-associated endonuclease Cas1; CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI YP_004411735.1 InterPro IPR010152; KEGG: dal:Dalk_4940 CRISPR-associated protein Cas2; PFAM: CRISPR-associated protein Cas2 subtype; SPTR: CRISPR-associated protein, Cas2; TIGRFAM: CRISPR-associated protein Cas2 subtype; IMG reference gene:2503957440; PFAM: CRISPR-associated protein (Cas_Cas2CT1978); TIGRFAM: CRISPR-associated endoribonuclease Cas2, subtype I-E/ECOLI YP_004411736.1 KEGG: yps:YPTB1831 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957442 YP_004411737.1 KEGG: ton:TON_0298 ABC-type iron(III)-siderophore transport system, ATPase component; SPTR: ABC-type iron(III)-siderophore transport system, ATPase component; IMG reference gene:2503957444 YP_004411738.1 KEGG: sgl:SG1747 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957445; PFAM: Domain of unknown function (DUF3427) YP_004411739.1 KEGG: brm:Bmur_2766 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957447 YP_004411740.1 KEGG: aau:AAur_3200 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957448; PFAM: Host cell surface-exposed lipoprotein YP_004411741.1 COGs: COG2865 transcriptional regulator protein; InterPro IPR007421; KEGG: gka:GK0575 hypothetical protein; PFAM: ATPase, AAA-4; SPTR: uncharacterized protein; IMG reference gene:2503957450; PFAM: Divergent AAA domain YP_004411742.1 SPTR: uncharacterized protein; IMG reference gene:2503957451 YP_004411743.1 KEGG: pru:PRU_1109 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957452 YP_004411744.1 KEGG: vex:VEA_002903 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957453 YP_004411745.1 KEGG: hwa:HQ2045A phosphoesterase; SPTR: uncharacterized protein; IMG reference gene:2503957455 YP_004411746.1 KEGG: cce:Ccel_2675 transposase mutator type; SPTR: Transposase; IMG reference gene:2503957456 YP_004411747.1 KEGG: csa:Csal_0698 cell division protein ZipA; SPTR: Cell division protein zipA; IMG reference gene:2503957457 YP_004411748.1 InterPro IPR013396; KEGG: mct:MCR_0030 CRISPR-associated Csy4 family protein; PFAM: CRISPR-associated protein Csy4; SPTR: uncharacterized protein; TIGRFAM: CRISPR-associated protein Csy4; IMG reference gene:2503957458; PFAM: CRISPR-associated protein (Cas_Csy4); TIGRFAM: CRISPR-associated protein Cas6/Csy4, subtype I-F/YPEST YP_004411749.1 InterPro IPR013399; KEGG: abb:ABBFA_000985 CRISPR-associated protein (Cas_Csy3) family protein; PFAM: CRISPR-associated protein Csy3; SPTR: CRISPR-associated protein, Csy3 family protein; TIGRFAM: CRISPR-associated protein Csy3; IMG reference gene:2503957459; PFAM: CRISPR-associated protein (Cas_Csy3); TIGRFAM: CRISPR type I-F/YPEST-associated protein Csy3 YP_004411750.1 InterPro IPR013398; KEGG: abb:ABBFA_000984 CRISPR-associated protein (Cas_Csy2) family protein; PFAM: CRISPR-associated protein Csy2; SPTR: uncharacterized protein; TIGRFAM: CRISPR-associated protein Csy2; IMG reference gene:2503957460; PFAM: CRISPR-associated protein (Cas_Csy2); TIGRFAM: CRISPR type I-F/YPEST-associated protein Csy2 YP_004411751.1 InterPro IPR013397; KEGG: abb:ABBFA_000983 hypothetical protein; PFAM: CRISPR-associated protein Csy1; SPTR: Crispr-associated protein, Csy1 family; TIGRFAM: CRISPR-associated protein Csy1; IMG reference gene:2503957461; PFAM: CRISPR-associated protein (Cas_Csy1); TIGRFAM: CRISPR type I-F/YPEST-associated protein Csy1 YP_004411752.1 COGs: COG1203 helicase; InterPro IPR013395; KEGG: shw:Sputw3181_2190 CRISPR-associated helicase Cas3 family protein; SPTR: uncharacterized protein; TIGRFAM: Helicase Cas3, CRISPR-associated, Yersinia-type; IMG reference gene:2503957462; TIGRFAM: CRISPR-associated helicase Cas3, subtype I-F/YPEST YP_004411753.1 COGs: COG1518 Uncharacterized protein predicted to be involved in DNA repair; InterPro IPR002729:IPR019857; KEGG: abb:ABBFA_000981 CRISPR-associated protein Cas1; PFAM: CRISPR-associated protein Cas1; SPTR: uncharacterized protein; TIGRFAM: CRISPR-associated protein Cas1, YPEST subtype; CRISPR-associated protein Cas1; IMG reference gene:2503957463; PFAM: CRISPR associated protein Cas1; TIGRFAM: CRISPR-associated endonuclease Cas1, subtype I-F/YPEST; CRISPR-associated endonuclease Cas1 YP_004411754.1 KEGG: fjo:Fjoh_2814 proline dehydrogenase; SPTR: uncharacterized protein; IMG reference gene:2503957464 YP_004411755.1 KEGG: cce:Ccel_2675 transposase mutator type; SPTR: Transposase; IMG reference gene:2503957465 YP_004411756.1 InterPro IPR011701; KEGG: cbt:CLH_1564 transport protein; PFAM: Major facilitator superfamily MFS-1; SPTR: Transport protein; IMG reference gene:2503957466; PFAM: Major Facilitator Superfamily YP_004411757.1 COGs: COG1533 DNA repair photolyase; InterPro IPR007197; KEGG: scb:SCAB_43781 hypothetical protein; PFAM: Radical SAM; SPTR: Radical SAM domain protein; IMG reference gene:2503957467; PFAM: Radical SAM superfamily YP_004411758.1 KEGG: clj:CLJU_c32650 prevent-host-death protein; SPTR: prevent-host-death protein; IMG reference gene:2503957468 YP_004411759.1 COGs: COG2865 transcriptional regulator protein; InterPro IPR007421; KEGG: pgi:PG1526 hypothetical protein; PFAM: ATPase, AAA-4; SPTR: Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen; IMG reference gene:2503957469; PFAM: Divergent AAA domain YP_004411760.1 InterPro IPR018891; KEGG: bai:BAA_3824 hypothetical protein; PFAM: Abortive phage infection; SPTR: uncharacterized protein; IMG reference gene:2503957471; PFAM: AIPR protein YP_004411761.1 KEGG: cac:CA_C0063 hypothetical protein; SPTR: tail fiber; IMG reference gene:2503957473 YP_004411762.1 KEGG: ssm:Spirs_2813 hypothetical protein; SPTR: Phage minor structural protein, ; IMG reference gene:2503957474 YP_004411763.1 KEGG: ppg:PputGB1_1758 hypothetical protein; SPTR: LigA; IMG reference gene:2503957475 YP_004411764.1 KEGG: dre:497403 im:7140452; SPTR: Tail tape meausure protein; IMG reference gene:2503957476 YP_004411765.1 KEGG: ssm:Spirs_2813 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957477 YP_004411766.1 KEGG: sha:SH1165 hypothetical protein; SPTR: Similar to FmtB/extracellular matrix binding protein; IMG reference gene:2503957478 YP_004411767.1 IMG reference gene:2503957480; PFAM: Oxaloacetate decarboxylase, gamma chain YP_004411768.1 COGs: COG1883 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase beta subunit; InterPro IPR005661; KEGG: csc:Csac_2482 sodium ion-translocating decarboxylase, beta subunit; PFAM: Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit; PRIAM: Glutaconyl-CoA decarboxylase; SPTR: Glutaconyl-CoA decarboxylase beta subunit; TIGRFAM: Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit; IMG reference gene:2503957481; PFAM: subunit; TIGRFAM: sodium ion-translocating decarboxylase, beta subunit YP_004411769.1 COGs: COG0569 K+ transport systems NAD-binding component; InterPro IPR003148:IPR006037; KEGG: cpy:Cphy_1928 TrkA domain-containing protein; PFAM: Regulator of K+ conductance, N-terminal; Regulator of K+ conductance, C-terminal; SPTR: Potassium uptake protein; IMG reference gene:2503957482; PFAM: TrkA-N domain; TrkA-C domain YP_004411770.1 COGs: COG0168 Trk-type K+ transport systems membrane components; InterPro IPR003445; KEGG: cpy:Cphy_1927 H(+)-transporting two-sector ATPase; PFAM: Cation transporter; PRIAM: H(+)-transporting two-sector ATPase; SPTR: H(+)-transporting two-sector ATPase; IMG reference gene:2503957483; PFAM: Cation transport protein; TIGRFAM: potassium uptake protein, TrkH family YP_004411771.1 COGs: COG0569 K+ transport systems NAD-binding component; InterPro IPR003148:IPR006037; KEGG: dap:Dacet_2986 TrkA-N domain protein; PFAM: Regulator of K+ conductance, N-terminal; Regulator of K+ conductance, C-terminal; SPTR: TrkA-N domain protein; IMG reference gene:2503957485; PFAM: TrkA-N domain; TrkA-C domain YP_004411772.1 COGs: COG0168 Trk-type K+ transport systems membrane components; InterPro IPR003445; KEGG: ddf:DEFDS_1538 K+ transport (Trk) system membrane component; PFAM: Cation transporter; SPTR: K+ transport (Trk) system, membrane component; IMG reference gene:2503957486; PFAM: Cation transport protein YP_004411773.1 KEGG: clj:CLJU_c17880 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957487; PFAM: DNA alkylation repair enzyme YP_004411774.1 COGs: COG2355 Zn-dependent dipeptidase microsomal dipeptidase homolog; InterPro IPR008257; KEGG: ctc:CTC00571 membrane dipeptidase; PFAM: Peptidase M19, renal dipeptidase; SPTR: Membrane dipeptidase; IMG reference gene:2503957488; PFAM: Membrane dipeptidase (Peptidase M19) YP_004411775.1 COGs: COG3118 Thioredoxin domain-containing protein; InterPro IPR013766:IPR005746; KEGG: ddf:DEFDS_1167 thioredoxin; PFAM: Thioredoxin domain; SPTR: Thioredoxin; TIGRFAM: Thioredoxin; IMG reference gene:2503957489; PFAM: Thioredoxin; TIGRFAM: thioredoxin YP_004411776.1 COGs: COG0778 Nitroreductase; InterPro IPR000415; KEGG: har:HEAR2542 oxidoreductase; PFAM: Nitroreductase-like; SPTR: Nitroreductase; IMG reference gene:2503957490; PFAM: Nitroreductase YP_004411777.1 COGs: COG1284 conserved hypothetical protein; InterPro IPR003740:IPR019264; KEGG: mta:Moth_0235 hypothetical protein; PFAM: Protein of unknown function DUF161; Domain of unknown function DUF2179; SPTR: uncharacterized protein; IMG reference gene:2503957491; PFAM: Uncharacterized BCR, YitT family COG1284; Uncharacterized protein conserved in bacteria (DUF2179) YP_004411778.1 COGs: COG0246 Mannitol-1-phosphate/altronate dehydrogenase; InterPro IPR013131:IPR013118; KEGG: cpy:Cphy_1062 mannitol dehydrogenase domain-containing protein; PFAM: Mannitol dehydrogenase, C-terminal; Mannitol dehydrogenase, N-terminal; PRIAM: Mannitol 2-dehydrogenase; SPTR: uncharacterized protein; IMG reference gene:2503957492; PFAM: Mannitol dehydrogenase C-terminal domain; Mannitol dehydrogenase Rossmann domain YP_004411779.1 COGs: COG1802 Transcriptional regulators; InterPro IPR000524:IPR011711; KEGG: amt:Amet_3789 GntR family transcriptional regulator; PFAM: HTH transcriptional regulator, GntR; GntR, C-terminal; SMART: HTH transcriptional regulator, GntR; GntR, C-terminal; SPTR: Transcriptional regulator, GntR family; IMG reference gene:2503957493; PFAM: Bacterial regulatory proteins, gntR family; FCD domain YP_004411780.1 COGs: COG1312 D-mannonate dehydratase; HAMAP: Mannonate dehydratase; InterPro IPR004628; KEGG: bpb:bpr_I0685 D-mannonate dehydratase UxuA; PFAM: Mannonate dehydratase; PRIAM: Mannonate dehydratase; SPTR: uncharacterized protein; TIGRFAM: Mannonate dehydratase; IMG reference gene:2503957494; PFAM: D-mannonate dehydratase (UxuA); TIGRFAM: mannonate dehydratase YP_004411781.1 InterPro IPR000182; KEGG: ssm:Spirs_3745 GCN5-related N-acetyltransferase; PFAM: GCN5-related N-acetyltransferase (GNAT) domain; SPTR: uncharacterized protein; IMG reference gene:2503957495; PFAM: Acetyltransferase (GNAT) family; Uncharacterised protein family (UPF0158) YP_004411782.1 COGs: COG0148 Enolase; HAMAP: Enolase; InterPro IPR000941:IPR020811:IPR020810; KEGG: ssm:Spirs_3747 enolase; PFAM: Enolase, C-terminal; Enolase, N-terminal; PRIAM: Phosphopyruvate hydratase; SPTR: Enolase; TIGRFAM: Enolase; IMG reference gene:2503957496; PFAM: Enolase, N-terminal domain; Enolase, C-terminal TIM barrel domain; TIGRFAM: phosphopyruvate hydratase YP_004411783.1 COGs: COG3250 Beta-galactosidase/beta-glucuronidase; InterPro IPR006104; KEGG: sro:Sros_3323 beta-galactosidase; PFAM: Glycoside hydrolase, family 2, carbohydrate-binding; SPTR: Glycoside hydrolase 2 sugar binding; IMG reference gene:2503957497; PFAM: Glycosyl hydrolases family 2, TIM barrel domain; Glycosyl hydrolases family 2, sugar binding domain YP_004411784.1 InterPro IPR011701; KEGG: sro:Sros_3322 hypothetical protein; PFAM: Major facilitator superfamily MFS-1; SPTR: uncharacterized protein; IMG reference gene:2503957498; PFAM: Major Facilitator Superfamily YP_004411785.1 COGs: COG2137 conserved hypothetical protein; HAMAP: Regulatory protein RecX; InterPro IPR003783; KEGG: ssm:Spirs_3751 regulatory protein RecX; PFAM: Regulatory protein RecX; SPTR: Regulatory protein recX; IMG reference gene:2503957499; PFAM: RecX family YP_004411786.1 COGs: COG0103 Ribosomal protein S9; InterPro IPR000754; KEGG: ssm:Spirs_3752 ribosomal protein S9; PFAM: Ribosomal protein S9; SPTR: 30S ribosomal protein S9; IMG reference gene:2503957500; PFAM: Ribosomal protein S9/S16 YP_004411787.1 COGs: COG0102 Ribosomal protein L13; InterPro IPR005822:IPR005823; KEGG: ssm:Spirs_3753 ribosomal protein L13; PFAM: Ribosomal protein L13; SPTR: 50S ribosomal protein L13; TIGRFAM: Ribosomal protein L13, bacterial-type; IMG reference gene:2503957501; PFAM: Ribosomal protein L13; TIGRFAM: ribosomal protein L13, bacterial type YP_004411788.1 KEGG: sta:STHERM_c21200 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957502; PFAM: Aminotransferase class-III YP_004411789.1 COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR000212; KEGG: ssm:Spirs_3757 UvrD/REP helicase; PFAM: DNA helicase, UvrD/REP type; SPTR: DNA helicase; IMG reference gene:2503957503; PFAM: UvrD/REP helicase YP_004411790.1 COGs: COG0621 2-methylthioadenine synthetase; HAMAP: Ribosomal protein S12 methylthiotransferase RimO; InterProIPR005840:IPR013848:IPR007197:IPR005839:IPR 006638; KEGG: sta:STHERM_c21230 hypothetical protein; PFAM: Methylthiotransferase, N-terminal; Radical SAM; SMART: Elongator protein 3/MiaB/NifB; SPTR: uncharacterized protein; TIGRFAM: Ribosomal protein S12 methylthiotransferase RimO; Methylthiotransferase; IMG reference gene:2503957504; PFAM: Radical SAM superfamily; Uncharacterized protein family UPF0004; TIGRFAM: ribosomal protein S12 methylthiotransferase RimO; radical SAM methylthiotransferase, MiaB/RimO family YP_004411791.1 COGs: COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems permease components; InterPro IPR000515; KEGG: sta:STHERM_c02770 oligopeptide ABC transporter permease; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Oligopeptide ABC transporter, permease; IMG reference gene:2503957505; PFAM: Binding-protein-dependent transport system inner membrane component YP_004411792.1 COGs: COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems permease components; InterPro IPR000515; KEGG: sta:STHERM_c02780 oligopeptide ABC transporter permease, inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Oligopeptide ABC transporter, permease, inner membrane component; IMG reference gene:2503957506; PFAM: Binding-protein-dependent transport system inner membrane component YP_004411793.1 COGs: COG0444 ABC-type dipeptide/oligopeptide/nickel transport system ATPase component; InterPro IPR003439:IPR013563:IPR010066:IPR003593; KEGG: sta:STHERM_c02790 oligopeptide/dipeptide ABC transporter ATP-binding protein-like protein; PFAM: ABC transporter-like; Oligopeptide/dipeptide ABC transporter, C-terminal; PRIAM: Nickel-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: Oligopeptide/dipeptide ABC transporter, ATP-binding protein-like protein; TIGRFAM: Oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal; IMG reference gene:2503957507; PFAM: ABC transporter; Oligopeptide/dipeptide transporter, C-terminal region; TIGRFAM: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain YP_004411794.1 COGs: COG1123 ATPase components of various ABC-type transport systems contain duplicated ATPase; InterPro IPR003439:IPR013563:IPR010066:IPR003593; KEGG: sta:STHERM_c02800 oligopeptide/dipeptide ABC transporter ATPase subunit; PFAM: ABC transporter-like; Oligopeptide/dipeptide ABC transporter, C-terminal; PRIAM: Nickel-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: Oligopeptide transporter; TIGRFAM: Oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal; IMG reference gene:2503957508; PFAM: ABC transporter; Oligopeptide/dipeptide transporter, C-terminal region; TIGRFAM: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain YP_004411795.1 KEGG: pst:PSPTO_3747 drug resistance transporter, EmrB/QacA family; SPTR: Cytochrome b; IMG reference gene:2503957509 YP_004411796.1 COGs: COG4166 ABC-type oligopeptide transport system periplasmic component; InterPro IPR000914; KEGG: sta:STHERM_c02760 oligopeptide ABC transporter periplasmic oligopeptide-binding protein; PFAM: Bacterial extracellular solute-binding protein, family 5; SPTR: Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein; IMG reference gene:2503957510; PFAM: Bacterial extracellular solute-binding proteins, family 5 Middle YP_004411797.1 COGs: COG1131 ABC-type multidrug transport system ATPase component; InterPro IPR003439:IPR003593; KEGG: bha:BH0818 bacitracin ABC transporter ATP-binding protein; PFAM: ABC transporter-like; PRIAM: Polyamine-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: uncharacterized protein; IMG reference gene:2503957512; PFAM: ABC transporter YP_004411798.1 KEGG: ere:EUBREC_3043 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957513 YP_004411799.1 COGs: COG1486 Alpha-galactosidase/6-phospho-beta-glucosidase 4 of glycosyl hydrolase; InterPro IPR001088; KEGG: csc:Csac_2748 glycoside hydrolase; PFAM: Glycoside hydrolase, family 4; PRIAM: Alpha-galactosidase; SPTR: Glycoside hydrolase 4; IMG reference gene:2503957514; PFAM: Family 4 glycosyl hydrolase; Family 4 glycosyl hydrolase C-terminal domain YP_004411800.1 COGs: COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain; InterPro IPR001789:IPR000005:IPR018060; KEGG: cpy:Cphy_0618 two component AraC family transcriptional regulator; PFAM: Signal transduction response regulator, receiver domain; HTH transcriptional regulator, AraC; SMART: Helix-turn-helix, AraC type, DNA binding domain; Signal transduction response regulator, receiver domain; SPTR: Two component transcriptional regulator, AraC family; IMG reference gene:2503957515; PFAM: Response regulator receiver domain; Bacterial regulatory helix-turn-helix proteins, AraC family YP_004411801.1 COGs: COG0395 ABC-type sugar transport system permease component; InterPro IPR000515; KEGG: ate:Athe_2374 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Binding-protein-dependent transport systems inner membrane component; IMG reference gene:2503957517; PFAM: Binding-protein-dependent transport system inner membrane component YP_004411802.1 COGs: COG1175 ABC-type sugar transport systems permease components; InterPro IPR000515; KEGG: ate:Athe_2375 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Binding-protein-dependent transport system inner membrane component; IMG reference gene:2503957518; PFAM: Binding-protein-dependent transport system inner membrane component YP_004411803.1 COGs: COG1653 ABC-type sugar transport system periplasmic component; InterPro IPR006059; KEGG: ate:Athe_2376 extracellular solute-binding protein family 1; PFAM: Bacterial extracellular solute-binding, family 1; SPTR: Extracellular solute-binding protein family 1; IMG reference gene:2503957519; PFAM: Bacterial extracellular solute-binding protein YP_004411804.1 COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR001509; KEGG: tit:Thit_2120 NAD-dependent epimerase/dehydratase; PFAM: NAD-dependent epimerase/dehydratase; SPTR: uncharacterized protein; IMG reference gene:2503957520; PFAM: NAD dependent epimerase/dehydratase; Sorbitol phosphotransferase enzyme II N-terminus YP_004411805.1 KEGG: cbe:Cbei_3173 TetR family transcriptional regulator; SPTR: Transcriptional regulator, TetR family; IMG reference gene:2503957521 YP_004411806.1 COGs: COG0095 Lipoate-protein ligase A; InterPro IPR004143:IPR019491:IPR004562; KEGG: cby:CLM_1876 lipoate-protein ligase A; PFAM: Biotin/lipoate A/B protein ligase; Lipoate protein ligase, C-terminal; SPTR: Lipoate--protein ligase; TIGRFAM: Lipoyltransferase/lipoate-protein ligase; IMG reference gene:2503957522; PFAM: Bacterial lipoate protein ligase C-terminus; Biotin/lipoate A/B protein ligase; TIGRFAM: lipoyltransferase and lipoate-protein ligase YP_004411807.1 COGs: COG1003 Glycine cleavage system protein P (pyridoxal-binding) C-terminal domain; InterPro IPR005814; KEGG: csh:Closa_1529 glycine dehydrogenase subunit 2; PFAM: Aminotransferase class-III; SPTR: uncharacterized protein; IMG reference gene:2503957523; PFAM: Glycine cleavage system P-protein YP_004411808.1 COGs: COG0403 Glycine cleavage system protein P (pyridoxal-binding) N-terminal domain; HAMAP: Glycine cleavage system P protein, subunit 1, InterPro IPR023010:IPR020580; KEGG: cpy:Cphy_1540 glycine dehydrogenase (decarboxylating); PFAM: Glycine cleavage system P-protein, N-terminal; PRIAM: Glycine dehydrogenase (decarboxylating); SPTR: uncharacterized protein; IMG reference gene:2503957524; PFAM: Glycine cleavage system P-protein YP_004411809.1 COGs: COG0509 Glycine cleavage system H protein (lipoate-binding); HAMAP: Glycine cleavage H-protein; InterPro IPR002930:IPR017453; KEGG: psa:PST_4063 glycine cleavage system protein H; PFAM: Glycine cleavage H-protein; SPTR: Glycine cleavage system H protein; TIGRFAM: Glycine cleavage H-protein, subgroup; IMG reference gene:2503957525; PFAM: Glycine cleavage H-protein; TIGRFAM: glycine cleavage system H protein YP_004411810.1 COGs: COG0404 Glycine cleavage system T protein (aminomethyltransferase); HAMAP: Aminomethyltransferase; InterPro IPR022903:IPR006222:IPR013977:IPR006223; KEGG: cpy:Cphy_1538 glycine cleavage system T protein; PFAM: Glycine cleavage T-protein, N-terminal; Glycine cleavage T-protein, C-terminal barrel; PRIAM: Aminomethyltransferase; SPTR: Aminomethyltransferase; TIGRFAM: Glycine cleavage system T protein; IMG reference gene:2503957526; PFAM: Aminomethyltransferase folate-binding domain; Glycine cleavage T-protein C-terminal barrel domain; TIGRFAM: glycine cleavage system T protein YP_004411811.1 InterPro IPR000086; KEGG: acl:ACL_1086 NTP pyrophosphohydrolase; PFAM: NUDIX hydrolase domain; SPTR: uncharacterized protein; IMG reference gene:2503957527; PFAM: NUDIX domain; TIGRFAM: mutator mutT protein YP_004411812.1 COGs: COG0679 permease; InterPro IPR004776; KEGG: ckr:CKR_1800 hypothetical protein; PFAM: Auxin efflux carrier; SPTR: uncharacterized protein; IMG reference gene:2503957528; PFAM: Membrane transport protein YP_004411813.1 COGs: COG1902 NADH:flavin oxidoreductase Old Yellow Enzyme family; InterPro IPR001155; KEGG: cbe:Cbei_0562 NADH:flavin oxidoreductase/NADH oxidase; PFAM: NADH:flavin oxidoreductase/NADH oxidase, N-terminal; PRIAM: NADPH dehydrogenase; SPTR: NADH:flavin oxidoreductase/NADH oxidase; IMG reference gene:2503957529; PFAM: NADH:flavin oxidoreductase / NADH oxidase YP_004411814.1 COGs: COG0225 Peptide methionine sulfoxide reductase; HAMAP: Peptide methionine sulphoxide reductase MsrA; InterPro IPR002569:IPR002579; KEGG: cbc:CbuK_1170 bifunctional methionine sulfoxide reductase B/A protein; PFAM: Peptide methionine sulphoxide reductase MsrA; Methionine sulphoxide reductase B; SPTR: Methionine-R-sulfoxide reductase/methionine-S-sulfoxide reductase; TIGRFAM: Peptide methionine sulphoxide reductase MsrA; IMG reference gene:2503957530; PFAM: SelR domain; Peptide methionine sulfoxide reductase; TIGRFAM: methionine-S-sulfoxide reductase; methionine-R-sulfoxide reductase YP_004411815.1 COGs: COG0428 divalent heavy-metal cations transporter; InterPro IPR003689; KEGG: cce:Ccel_1427 zinc/iron permease; PFAM: Zinc/iron permease; SPTR: Zinc/iron permease; IMG reference gene:2503957531; PFAM: ZIP Zinc transporter YP_004411816.1 COGs: COG1295 membrane protein; InterPro IPR004664:IPR017039; KEGG: acd:AOLE_02310 tRNA-processing ribonuclease BN(RNase BN); PFAM: Ribonuclease BN-related; SPTR: Ribonuclease; TIGRFAM: Ribonuclease BN; IMG reference gene:2503957532; PFAM: Ribonuclease BN-like family; TIGRFAM: YihY family protein (not ribonuclease BN) YP_004411817.1 COGs: COG2267 Lysophospholipase; InterPro IPR000073; KEGG: amt:Amet_0462 alpha/beta hydrolase fold; PFAM: Alpha/beta hydrolase fold-1; SPTR: PLA depolymerase; IMG reference gene:2503957533; PFAM: lysophospholipase YP_004411818.1 COGs: COG0622 phosphoesterase; InterPro IPR004843; KEGG: mta:Moth_0919 phosphodiesterase; PFAM: Metallo-dependent phosphatase; SPTR: uncharacterized protein; IMG reference gene:2503957534; PFAM: Calcineurin-like phosphoesterase; TIGRFAM: phosphoesterase, MJ0936 family YP_004411819.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR013378:IPR011110:IPR000408; KEGG: mxa:MXAN_0889 RCC1 repeat-containing protein; PFAM: Listeria/Bacterioides repeat; Two component regulator propeller; Regulator of chromosome condensation, RCC1; SPTR: uncharacterized protein; IMG reference gene:2503957535; PFAM: Listeria-Bacteroides repeat domain (List_Bact_rpt); Regulator of chromosome condensation (RCC1) repeat YP_004411820.1 COGs: COG2414 Aldehyde:ferredoxin oxidoreductase; InterPro IPR013983:IPR001203; KEGG: dol:Dole_1771 aldehyde ferredoxin oxidoreductase; PFAM: Aldehyde ferredoxin oxidoreductase, N-terminal; Aldehyde ferredoxin oxidoreductase, C-terminal; PRIAM: Aldehyde ferredoxin oxidoreductase; SMART: Aldehyde ferredoxin oxidoreductase, N-terminal; SPTR: Aldehyde ferredoxin oxidoreductase; IMG reference gene:2503957536; PFAM: Aldehyde ferredoxin oxidoreductase, N-terminal domain; Aldehyde ferredoxin oxidoreductase, domains 2 & 3 YP_004411821.1 COGs: COG0572 Uridine kinase; InterPro IPR003593; KEGG: ssm:Spirs_3160 AAA ATPase; SMART: ATPase, AAA+ type, core; SPTR: Uridine kinase; IMG reference gene:2503957537; PFAM: Phosphoribulokinase / Uridine kinase YP_004411822.1 COGs: COG3177 conserved hypothetical protein; InterPro IPR003812; KEGG: gox:GOX2572 hypothetical protein; PFAM: Filamentation induced by cAMP/death on curing-related; SPTR: uncharacterized protein; IMG reference gene:2503957538; PFAM: Fic/DOC family YP_004411823.1 COGs: COG2983 conserved hypothetical protein; KEGG: ssm:Spirs_3171 protein of unknown function UPF0153; SPTR: cytoplasmic protein; manually curated; IMG reference gene:2503957539 YP_004411824.1 COGs: COG0496 acid phosphatase; HAMAP: Survival protein SurE-like phosphatase/nucleotidase; InterPro IPR002828; KEGG: ssm:Spirs_3174 stationary-phase survival protein SurE; PFAM: Survival protein SurE-like phosphatase/nucleotidase; SPTR: 5'-nucleotidase surE; TIGRFAM: Survival protein SurE-like phosphatase/nucleotidase; IMG reference gene:2503957540; PFAM: Survival protein SurE; TIGRFAM: 5'/3'-nucleotidase SurE YP_004411825.1 COGs: COG0153 Galactokinase; KEGG: ssm:Spirs_3175 galactokinase; PRIAM: Galactokinase; SPTR: uncharacterized protein; IMG reference gene:2503957541; PFAM: Galactokinase galactose-binding signature YP_004411826.1 COGs: COG0254 Ribosomal protein L31; HAMAP: Ribosomal protein L31; InterPro IPR002150; KEGG: ssm:Spirs_3178 ribosomal protein L31; PFAM: Ribosomal protein L31; SPTR: 50S ribosomal protein L31; TIGRFAM: Ribosomal protein L31; IMG reference gene:2503957542; PFAM: Ribosomal protein L31; TIGRFAM: ribosomal protein L31 YP_004411827.1 COGs: COG1158 Transcription termination factor; InterProIPR011112:IPR011129:IPR003593:IPR004665:IPR 011113:IPR000194; KEGG: ssm:Spirs_3179 transcription termination factor Rho; PFAM: ATPase, alpha/beta subunit, nucleotide-binding domain; Rho termination factor, RNA-binding; SMART: Cold shock protein; Rho termination factor, N-terminal; ATPase, AAA+ type, core; SPTR: Transcription termination factor Rho; TIGRFAM: Transcription termination factor Rho; IMG reference gene:2503957543; PFAM: Rho termination factor, N-terminal domain; Rho termination factor, RNA-binding domain; ATP synthase alpha/beta family, nucleotide-binding domain; TIGRFAM: transcription termination factor Rho YP_004411828.1 COGs: COG1546 Uncharacterized protein (competence- and mitomycin-induced); InterPro IPR001453:IPR008136; KEGG: ssm:Spirs_3180 competence/damage-inducible protein CinA; PFAM: CinA, C-terminal; Molybdopterin binding; SMART: Molybdopterin binding; SPTR: CinA-like protein; TIGRFAM: CinA, C-terminal; IMG reference gene:2503957544; PFAM: Probable molybdopterin binding domain; Competence-damaged protein; TIGRFAM: competence/damage-inducible protein CinA N-terminal domain; competence/damage-inducible protein CinA C-terminal domain; molybdenum cofactor synthesis domain YP_004411829.1 COGs: COG0815 Apolipoprotein N-acyltransferase; HAMAP: Apolipoprotein N-acyltransferase; InterPro IPR004563:IPR003010; KEGG: ssm:Spirs_3184 apolipoprotein N-acyltransferase; PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; SPTR: uncharacterized protein; TIGRFAM: Apolipoprotein N-acyltransferase; IMG reference gene:2503957545; PFAM: Carbon-nitrogen hydrolase; TIGRFAM: apolipoprotein N-acyltransferase YP_004411830.1 COGs: COG0776 Bacterial nucleoid DNA-binding protein; InterPro IPR000119; KEGG: ssm:Spirs_3185 histone family protein DNA-binding protein; PFAM: Histone-like bacterial DNA-binding protein; SMART: Histone-like bacterial DNA-binding protein; SPTR: DNA-binding protein HbbU; IMG reference gene:2503957546; PFAM: Bacterial DNA-binding protein YP_004411831.1 HAMAP: Ribosomal protein S20; InterPro IPR002583; KEGG: sta:STHERM_c18580 30S ribosomal protein S20; PFAM: Ribosomal protein S20; SPTR: 30S ribosomal protein S20; TIGRFAM: Ribosomal protein S20; IMG reference gene:2503957547; PFAM: Ribosomal protein S20; TIGRFAM: ribosomal protein S20 YP_004411832.1 COGs: COG1774 Uncharacterized homolog of PSP1; InterPro IPR007557; KEGG: sta:STHERM_c18600 hypothetical protein; PFAM: PSP1, C-terminal; SPTR: uncharacterized protein; IMG reference gene:2503957548; PFAM: PSP1 C-terminal conserved region YP_004411833.1 COGs: COG0738 Fucose permease; InterPro IPR011701; KEGG: csh:Closa_1055 major facilitator superfamily MFS_1; PFAM: Major facilitator superfamily MFS-1; SPTR: uncharacterized protein; IMG reference gene:2503957549; PFAM: Major Facilitator Superfamily YP_004411834.1 COGs: COG0084 Mg-dependent DNase; InterPro IPR015991:IPR001130; KEGG: ssm:Spirs_3191 hydrolase, TatD family; PFAM: Deoxyribonuclease, TatD-related; SPTR: uncharacterized protein; TIGRFAM: Deoxyribonuclease, TatD Mg-dependent, prokaryote; IMG reference gene:2503957551; PFAM: TatD related DNase; TIGRFAM: hydrolase, TatD family YP_004411835.1 COGs: COG0042 tRNA-dihydrouridine synthase; InterPro IPR004652:IPR001269; KEGG: ssm:Spirs_3192 TIM-barrel protein, nifR3 family; PFAM: tRNA-dihydrouridine synthase; SPTR: tRNA-dihydrouridine synthase B; TIGRFAM: tRNA-dihydrouridine synthase, TIM-barrel, NifR3; IMG reference gene:2503957552; PFAM: Dihydrouridine synthase (Dus); TIGRFAM: TIM-barrel protein, nifR3 family YP_004411836.1 KEGG: pmy:Pmen_3843 alpha/beta hydrolase fold; SPTR: Alpha/beta hydrolase fold; IMG reference gene:2503957553 YP_004411837.1 COGs: COG0151 Phosphoribosylamine-glycine ligase; InterPro IPR000115:IPR020562:IPR020561:IPR020560; KEGG: ssm:Spirs_3193 phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C-domain; PRIAM: Phosphoribosylamine--glycine ligase; SPTR: Phosphoribosylamine--glycine ligase; TIGRFAM: Phosphoribosylglycinamide synthetase; IMG reference gene:2503957554; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C domain; TIGRFAM: phosphoribosylamine--glycine ligase YP_004411838.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR013378:IPR011110:IPR000408; KEGG: aeh:Mlg_2687 regulator of chromosome condensation, RCC1; PFAM: Listeria/Bacterioides repeat; Two component regulator propeller; Regulator of chromosome condensation, RCC1; SPTR: uncharacterized protein; IMG reference gene:2503957555; PFAM: Listeria-Bacteroides repeat domain (List_Bact_rpt); Regulator of chromosome condensation (RCC1) repeat YP_004411839.1 COGs: COG0667 oxidoreductase (related to aryl-alcohol dehydrogenase); InterPro IPR023210; KEGG: gym:GYMC10_1614 aldo/keto reductase; PFAM: NADP-dependent oxidoreductase domain; SPTR: Aldo/keto reductase; IMG reference gene:2503957556; PFAM: Aldo/keto reductase YP_004411840.1 KEGG: ssm:Spirs_4225 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957557 YP_004411841.1 COGs: COG2148 Sugar transferase involved in lipopolysaccharide synthesis; InterPro IPR003362; KEGG: ccb:Clocel_3670 undecaprenyl-phosphate glucose phosphotransferase; PFAM: Bacterial sugar transferase; PRIAM: Undecaprenyl-phosphate galactose phosphotransferase; SPTR: uncharacterized protein; IMG reference gene:2503957558; PFAM: Bacterial sugar transferase; TIGRFAM: exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase YP_004411842.1 KEGG: xca:xccb100_1061 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957559 YP_004411843.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR011110:IPR000408; KEGG: aeh:Mlg_2687 regulator of chromosome condensation, RCC1; PFAM: Regulator of chromosome condensation, RCC1; Two component regulator propeller; SPTR: Alpha-tubulin suppressor and related RCC1 domain-containing protein-like protein; IMG reference gene:2503957560; PFAM: Regulator of chromosome condensation (RCC1) repeat YP_004411844.1 InterPro IPR011435; KEGG: csh:Closa_3302 protein of unknown function DUF1538; PFAM: Protein of unknown function DUF1538; SPTR: uncharacterized protein; IMG reference gene:2503957561; PFAM: Protein of unknown function (DUF1538) YP_004411845.1 COGs: COG1088 dTDP-D-glucose 4 6-dehydratase; InterPro IPR005888:IPR001509; KEGG: cbe:Cbei_4754 dTDP-glucose 4,6-dehydratase; PFAM: NAD-dependent epimerase/dehydratase; PRIAM: dTDP-glucose 4,6-dehydratase; SPTR: dTDP-glucose 4,6-dehydratase; TIGRFAM: dTDP-glucose 4,6-dehydratase; IMG reference gene:2503957563; PFAM: NAD dependent epimerase/dehydratase; TIGRFAM: dTDP-glucose 4,6-dehydratase YP_004411846.1 COGs: COG0524 Sugar kinase ribokinase; InterPro IPR011611; KEGG: ssm:Spirs_1177 PfkB domain protein; PFAM: Carbohydrate/purine kinase; PRIAM: Ribokinase; SPTR: uncharacterized protein; IMG reference gene:2503957564; PFAM: pfkB family carbohydrate kinase; TIGRFAM: ribokinase YP_004411847.1 COGs: COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems permease components; InterPro IPR001851; KEGG: dsh:Dshi_0528 ribose/xylose/arabinose/galactoside ABC-type transport system protein; PFAM: ABC transporter permease; SPTR: Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components; IMG reference gene:2503957565; PFAM: Branched-chain amino acid transport system / permease component YP_004411848.1 COGs: COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems permease components; InterPro IPR001851; KEGG: dsh:Dshi_0529 ribose/xylose/arabinose/galactoside ABC-type transport system protein; PFAM: ABC transporter permease; SPTR: uncharacterized protein; IMG reference gene:2503957566; PFAM: Branched-chain amino acid transport system / permease component YP_004411849.1 COGs: COG1129 ABC-type sugar transport system ATPase component; InterPro IPR003593:IPR003439; KEGG: azl:AZL_b05830 simple sugar transport system ATP-binding protein; PFAM: ABC transporter-like; PRIAM: Monosaccharide-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: Monosaccharide ABC transporter ATP-binding protein, CUT2 family (TC 3.A.1.2.-); IMG reference gene:2503957567; PFAM: ABC transporter YP_004411850.1 COGs: COG1879 ABC-type sugar transport system periplasmic component; KEGG: dsh:Dshi_0531 ribose/xylose/arabinose/galactoside ABC-type transport system protein; SPTR: uncharacterized protein; IMG reference gene:2503957568; PFAM: family YP_004411851.1 COGs: COG1609 Transcriptional regulators; InterPro IPR000843:IPR001761; KEGG: dap:Dacet_0215 transcriptional regulator, LacI family; PFAM: HTH transcriptional regulator, LacI; Periplasmic binding protein/LacI transcriptional regulator; SMART: HTH transcriptional regulator, LacI; SPTR: Transcriptional regulator, LacI family; IMG reference gene:2503957569; PFAM: Bacterial regulatory proteins, lacI family; family YP_004411852.1 COGs: COG1082 Sugar phosphate isomerase/epimerase; InterPro IPR012307; KEGG: pwa:Pecwa_2644 xylose isomerase domain protein TIM barrel; PFAM: Xylose isomerase, TIM barrel domain; SPTR: Xylose isomerase domain protein TIM barrel; IMG reference gene:2503957570; PFAM: Xylose isomerase-like TIM barrel YP_004411853.1 InterPro IPR011493; KEGG: swo:Swol_1078 Ig-like domain-containing protein; SPTR: Surface proteins containing Ig-like domains-like; IMG reference gene:2503957571; PFAM: The GLUG motif YP_004411854.1 KEGG: bfr:BF3846 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957572 YP_004411855.1 KEGG: bfs:BF1484 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957573 YP_004411856.1 KEGG: mpi:Mpet_0889 extracellular solute-binding protein family 5; SPTR: uncharacterized protein; IMG reference gene:2503957574 YP_004411857.1 COGs: COG4571 Outer membrane protease; KEGG: tde:TDE2032 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957575; PFAM: Omptin family YP_004411858.1 KEGG: spw:SPCG_1762 subtilisin-like serine protease; SPTR: uncharacterized protein; IMG reference gene:2503957576; PFAM: Subtilase YP_004411859.1 COGs: COG0464 ATPase of the AAA+ class; InterPro IPR003593:IPR003959; KEGG: mmy:MSC_1062 AAA ATPase; PFAM: ATPase, AAA-type, core; SMART: ATPase, AAA+ type, core; SPTR: AAA ATPase; IMG reference gene:2503957577; PFAM: ATPase associated with various cellular activities (AAA) YP_004411860.1 COGs: COG1611 Rossmann fold nucleotide-binding protein; InterPro IPR005269; KEGG: gsu:GSU2766 decarboxylase; PFAM: Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG; SPTR: Decarboxylase; TIGRFAM: Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG; IMG reference gene:2503957578; PFAM: Possible lysine decarboxylase; TIGRFAM: TIGR00725 family protein; TIGR00730 family protein YP_004411861.1 KEGG: tde:TDE0603 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957579 YP_004411862.1 COGs: COG1132 ABC-type multidrug transport system ATPase and permease components; InterPro IPR003593:IPR001140:IPR003439; KEGG: cpy:Cphy_3379 ABC transporter transmembrane region; PFAM: ABC transporter-like; ABC transporter, transmembrane domain; PRIAM: Xenobiotic-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter transmembrane protein; IMG reference gene:2503957582; PFAM: ABC transporter transmembrane region; ABC transporter YP_004411863.1 COGs: COG1132 ABC-type multidrug transport system ATPase and permease components; InterPro IPR003593:IPR001140:IPR003439; KEGG: cpy:Cphy_3380 ABC transporter transmembrane region; PFAM: ABC transporter-like; ABC transporter, transmembrane domain; PRIAM: Xenobiotic-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter transmembrane protein; IMG reference gene:2503957583; PFAM: ABC transporter transmembrane region; ABC transporter YP_004411864.1 COGs: COG1846 Transcriptional regulators; InterPro IPR000835; KEGG: cdl:CDR20291_3067 MarR-family transcriptional regulator; PFAM: HTH transcriptional regulator, MarR; SMART: HTH transcriptional regulator, MarR; SPTR: Predicted protein; IMG reference gene:2503957584; PFAM: MarR family YP_004411865.1 COGs: COG0698 Ribose 5-phosphate isomerase RpiB; InterPro IPR003500; KEGG: cpy:Cphy_0491 hypothetical protein; PFAM: Ribose/galactose isomerase; SPTR: uncharacterized protein; IMG reference gene:2503957585; PFAM: Ribose-5-phosphate isomerase; Ribose/Galactose Isomerase YP_004411866.1 KEGG: tde:TDE1234 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957586 YP_004411867.1 COGs: COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain; InterPro IPR018060:IPR000005; KEGG: bpb:bpr_III019 AraC family transcriptional regulator; PFAM: HTH transcriptional regulator, AraC; SMART: Helix-turn-helix, AraC type, DNA binding domain; SPTR: uncharacterized protein; IMG reference gene:2503957587; PFAM: Bacterial regulatory helix-turn-helix proteins, AraC family YP_004411868.1 KEGG: str:Sterm_4037 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957588 YP_004411869.1 COGs: COG1653 ABC-type sugar transport system periplasmic component; InterPro IPR006059; KEGG: str:Sterm_4038 extracellular solute-binding protein family 1; PFAM: Bacterial extracellular solute-binding, family 1; SPTR: uncharacterized protein; IMG reference gene:2503957589; PFAM: Bacterial extracellular solute-binding protein YP_004411870.1 COGs: COG1175 ABC-type sugar transport systems permease components; InterPro IPR000515; KEGG: scb:SCAB_8181 integral membrane binding-protein-dependent transport protein; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: uncharacterized protein; IMG reference gene:2503957590; PFAM: Binding-protein-dependent transport system inner membrane component YP_004411871.1 COGs: COG0395 ABC-type sugar transport system permease component; InterPro IPR000515; KEGG: str:Sterm_4035 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: uncharacterized protein; IMG reference gene:2503957591; PFAM: Binding-protein-dependent transport system inner membrane component YP_004411872.1 COGs: COG0383 Alpha-mannosidase; InterPro IPR015341:IPR000602:IPR011682; KEGG: tit:Thit_1713 glycosyl hydrolase 38 domain protein; PFAM: Glycoside hydrolase, family 38, core; Glycoside hydrolase, family 38, central domain; Glycosyl hydrolases 38, C-terminal; PRIAM: Alpha-mannosidase; SMART: Glycoside hydrolase, family 38, central domain; SPTR: Glycosyl hydrolase 38 domain protein; IMG reference gene:2503957592; PFAM: Glycosyl hydrolases family 38 C-terminal domain; Glycosyl hydrolases family 38 N-terminal domain; Alpha mannosidase, middle domain YP_004411873.1 COGs: COG4225 unsaturated glucuronyl hydrolase involved in regulation of surface properties and related protein; InterPro IPR010905; KEGG: bpb:bpr_III020 unsaturated rhamnogalacturonyl hydrolase Gh105C; PFAM: Glycosyl hydrolase, family 88; SPTR: uncharacterized protein; IMG reference gene:2503957593; PFAM: Glycosyl Hydrolase 88 YP_004411874.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR013378:IPR011110:IPR000408; KEGG: aeh:Mlg_2687 regulator of chromosome condensation, RCC1; PFAM: Listeria/Bacterioides repeat; Two component regulator propeller; Regulator of chromosome condensation, RCC1; SPTR: uncharacterized protein; IMG reference gene:2503957594; PFAM: Listeria-Bacteroides repeat domain (List_Bact_rpt); Regulator of chromosome condensation (RCC1) repeat YP_004411875.1 COGs: COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolase; InterPro IPR001310; KEGG: ddf:DEFDS_1906 histidine triad family protein; PFAM: Histidine triad (HIT) protein; SPTR: Histidine triad family protein; IMG reference gene:2503957595; PFAM: HIT domain YP_004411876.1 COGs: COG1225 Peroxiredoxin; InterPro IPR000866; KEGG: hha:Hhal_0101 redoxin domain-containing protein; PFAM: Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant; SPTR: Redoxin domain protein; IMG reference gene:2503957596; PFAM: AhpC/TSA family YP_004411877.1 KEGG: sru:SRU_2861 endonuclease/exonuclease/phosphatase; SPTR: Endonuclease/exonuclease/phosphatase; IMG reference gene:2503957597 YP_004411878.1 COGs: COG0072 Phenylalanyl-tRNA synthetase beta subunit; InterPro IPR005146:IPR005147:IPR004531; KEGG: ssm:Spirs_4135 phenylalanyl-tRNA synthetase, beta subunit; PFAM: tRNA synthetase, B5; PRIAM: Phenylalanine--tRNA ligase; SMART: tRNA synthetase, B5; B3/B4 tRNA-binding domain; SPTR: Phenylalanyl-tRNA synthetase, beta subunit; TIGRFAM: Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archae/euk cytosolic; IMG reference gene:2503957598; PFAM: tRNA synthetase B5 domain; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit YP_004411879.1 COGs: COG0016 Phenylalanyl-tRNA synthetase alpha subunit; HAMAP: Phenylalanyl-tRNA synthetase alpha chain 2, bacterial/archaeal; InterPro IPR004529:IPR002319:IPR022917; KEGG: ssm:Spirs_4136 phenylalanyl-tRNA synthetase, alpha subunit; PFAM: Phenylalanyl-tRNA synthetase; SPTR: Phenylalanyl-tRNA synthetase, alpha subunit; TIGRFAM: Phenylalanyl-tRNA synthetase, class IIc, alpha subunit; IMG reference gene:2503957599; PFAM: tRNA synthetases class II core domain (F); TIGRFAM: phenylalanyl-tRNA synthetase, alpha subunit YP_004411880.1 KEGG: ckr:CKR_2225 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957600 YP_004411881.1 COGs: COG0673 dehydrogenase and related protein; InterPro IPR000683:IPR004104; KEGG: bhy:BHWA1_00926 oxidoreductase domain containing protein; PFAM: Oxidoreductase, N-terminal; Oxidoreductase, C-terminal; PRIAM: Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; SPTR: uncharacterized protein; IMG reference gene:2503957601; PFAM: Oxidoreductase, NAD-binding Rossmann fold YP_004411882.1 COGs: COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit; InterPro IPR005475:IPR001017:IPR005476; KEGG: jan:Jann_3081 dehydrogenase, E1 component; PFAM: Dehydrogenase, E1 component; Transketolase-like, pyrimidine-binding domain; Transketolase, C-terminal; PRIAM: Pyruvate dehydrogenase (acetyl-transferring); SMART: Transketolase-like, pyrimidine-binding domain; SPTR: Dehydrogenase E1 component; IMG reference gene:2503957602; PFAM: Dehydrogenase E1 component; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain YP_004411883.1 KEGG: sta:STHERM_c16640 flavoredoxin; SPTR: uncharacterized protein; IMG reference gene:2503957603 YP_004411884.1 COGs: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; InterPro IPR005904:IPR000836; KEGG: dae:Dtox_0723 hypoxanthine phosphoribosyltransferase; PFAM: Phosphoribosyltransferase; PRIAM: Hypoxanthine phosphoribosyltransferase; SPTR: uncharacterized protein; TIGRFAM: Hypoxanthine phosphoribosyl transferase; IMG reference gene:2503957604; PFAM: Phosphoribosyl transferase domain; TIGRFAM: hypoxanthine phosphoribosyltransferase YP_004411885.1 COGs: COG2236 phosphoribosyltransferase; InterPro IPR000836; KEGG: sta:STHERM_c19080 hypothetical protein; PFAM: Phosphoribosyltransferase; SPTR: uncharacterized protein; IMG reference gene:2503957605; PFAM: Phosphoribosyl transferase domain YP_004411886.1 COGs: COG0104 Adenylosuccinate synthase; HAMAP: Adenylosuccinate synthetase; InterPro IPR001114; KEGG: dly:Dehly_0529 adenylosuccinate synthetase; PFAM: Adenylosuccinate synthetase; PRIAM: Adenylosuccinate synthase; SMART: Adenylosuccinate synthetase; SPTR: Adenylosuccinate synthetase; TIGRFAM: Adenylosuccinate synthetase; IMG reference gene:2503957606; PFAM: Adenylosuccinate synthetase; TIGRFAM: adenylosuccinate synthase YP_004411887.1 COGs: COG0687 Spermidine/putrescine-binding periplasmic protein; InterPro IPR006059; KEGG: tpp:TPASS_0655 spermidine/putrescine ABC transporter, periplasmic binding protein; PFAM: Bacterial extracellular solute-binding, family 1; SPTR: Spermidine/putrescine ABC transporter, periplasmic binding protein; IMG reference gene:2503957607; PFAM: Bacterial extracellular solute-binding protein YP_004411888.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR013378:IPR000408; KEGG: mxa:MXAN_0889 RCC1 repeat-containing protein; PFAM: Regulator of chromosome condensation, RCC1; Listeria/Bacterioides repeat; SPTR: Alpha-tubulin suppressor and related RCC1 domain-containing protein-like protein; IMG reference gene:2503957608; PFAM: Listeria-Bacteroides repeat domain (List_Bact_rpt); Regulator of chromosome condensation (RCC1) repeat YP_004411889.1 COGs: COG0015 Adenylosuccinate lyase; InterPro IPR004769:IPR022761:IPR019468; KEGG: cpy:Cphy_3043 adenylosuccinate lyase; PFAM: Lyase 1, N-terminal; Adenylosuccinate lyase C-terminal metazoa/fungi; SPTR: uncharacterized protein; TIGRFAM: Adenylosuccinate lyase; IMG reference gene:2503957609; PFAM: Lyase; Adenylosuccinate lyase C-terminus; TIGRFAM: adenylosuccinate lyase YP_004411890.1 InterPro IPR015414; KEGG: neu:NE1198 hypothetical protein; PFAM: SNARE associated Golgi protein; SPTR: uncharacterized protein; IMG reference gene:2503957610; PFAM: SNARE associated Golgi protein YP_004411891.1 COGs: COG2872 metal-dependent hydrolase related to alanyl-tRNA synthetase HxxxH domain; InterPro IPR012947:IPR018164; KEGG: ssm:Spirs_0879 alanyl-tRNA synthetase, class IIc; PFAM: Alanyl-tRNA synthetase, class IIc, N-terminal; Threonyl/alanyl tRNA synthetase, SAD; SMART: Threonyl/alanyl tRNA synthetase, SAD; SPTR: Threonyl/alanyl tRNA synthetase SAD; IMG reference gene:2503957611; PFAM: Threonyl and Alanyl tRNA synthetase second additional domain; tRNA synthetases class II (A) YP_004411892.1 KEGG: ssm:Spirs_0875 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957612 YP_004411893.1 KEGG: dac:Daci_0587 cytochrome c biogenesis protein transmembrane region; SPTR: Cytochrome c biogenesis protein transmembrane region; IMG reference gene:2503957613 YP_004411894.1 KEGG: gpb:HDN1F_10950 hypothetical protein; SPTR: Diheme Cytochrome c-type; IMG reference gene:2503957615 YP_004411895.1 KEGG: osa:4345910 hypothetical protein; SPTR: Whole genome shotgun sequence assembly, scaffold_63; IMG reference gene:2503957616 YP_004411896.1 COGs: COG2968 conserved hypothetical protein; InterPro IPR007497; KEGG: nha:Nham_3577 hypothetical protein; PFAM: Protein of unknown function DUF541; SPTR: uncharacterized protein; IMG reference gene:2503957617; PFAM: Protein of unknown function (DUF541) YP_004411897.1 InterPro IPR000086; KEGG: ssm:Spirs_0637 NUDIX hydrolase; PFAM: NUDIX hydrolase domain; SPTR: MutT/nudix family protein; IMG reference gene:2503957618; PFAM: NUDIX domain YP_004411898.1 COGs: COG0489 ATPase involved in chromosome partitioning; InterPro IPR019591; KEGG: ssm:Spirs_0254 ATPase-like, ParA/MinD; PFAM: ATPase-like, ParA/MinD; SPTR: Iron-sulfur cluster assembly/repair protein; IMG reference gene:2503957619; PFAM: ParA/MinD ATPase like; Anion-transporting ATPase YP_004411899.1 KEGG: rop:ROP_14030 serine/threonine protein kinase; SPTR: serine/threonine protein kinase; IMG reference gene:2503957620 YP_004411900.1 COGs: COG5016 Pyruvate/oxaloacetate carboxyltransferase; InterPro IPR000891:IPR000089; KEGG: ssm:Spirs_4017 biotin/lipoyl attachment domain-containing protein; PFAM: Biotin/lipoyl attachment; Pyruvate carboxyltransferase; PRIAM: Pyruvate carboxylase; SPTR: Pyruvate carboxylase, beta chain; IMG reference gene:2503957621; PFAM: HMGL-like; Biotin-requiring enzyme; Conserved carboxylase domain YP_004411901.1 COGs: COG2131 Deoxycytidylate deaminase; InterPro IPR002125; KEGG: clo:HMPREF0868_0032 cytidine and deoxycytidylate deaminase zinc-binding region; PFAM: CMP/dCMP deaminase, zinc-binding; PRIAM: dCMP deaminase; SPTR: dCMP deaminase; IMG reference gene:2503957622; PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region YP_004411902.1 KEGG: seu:SEQ_1013 signal peptidase I; SPTR: signal peptidase I; IMG reference gene:2503957623 YP_004411903.1 COGs: COG1321 Mn-dependent transcriptional regulator protein; InterPro IPR022689:IPR022687:IPR001367; KEGG: dhd:Dhaf_1581 iron (metal) dependent repressor, DtxR family; PFAM: Iron dependent repressor, N-terminal; Iron dependent repressor; SMART: Iron dependent repressor, diptheria toxin type; SPTR: Iron (Metal) dependent repressor, DtxR family; IMG reference gene:2503957624; PFAM: Iron dependent repressor, metal binding and dimerisation domain; Iron dependent repressor, N-terminal DNA binding domain YP_004411904.1 COGs: COG1893 Ketopantoate reductase; InterPro IPR003710:IPR013332:IPR013752; KEGG: fsu:Fisuc_0919 2-dehydropantoate 2-reductase; PFAM: Ketopantoate reductase ApbA/PanE, N-terminal; Ketopantoate reductase ApbA/PanE, C-terminal; PRIAM: 2-dehydropantoate 2-reductase; SPTR: 2-dehydropantoate 2-reductase; TIGRFAM: Ketopantoate reductase ApbA/PanE; IMG reference gene:2503957625; PFAM: Ketopantoate reductase PanE/ApbA; Ketopantoate reductase PanE/ApbA C terminal; TIGRFAM: 2-dehydropantoate 2-reductase YP_004411905.1 COGs: COG0349 Ribonuclease D; InterPro IPR002562; KEGG: ssm:Spirs_1372 3'-5' exonuclease; PFAM: 3'-5' exonuclease; SMART: 3'-5' exonuclease; SPTR: 3'-5' exonuclease; IMG reference gene:2503957626; PFAM: 3'-5' exonuclease; HRDC domain YP_004411906.1 COGs: COG1274 Phosphoenolpyruvate carboxykinase (GTP); HAMAP: Phosphoenolpyruvate carboxykinase, GTP-utilising; InterPro IPR008209; KEGG: tpp:TPASS_0122 phosphoenolpyruvate carboxykinase; PFAM: Phosphoenolpyruvate carboxykinase, GTP-utilising; PRIAM: Phosphoenolpyruvate carboxykinase (GTP); SPTR: Phosphoenolpyruvate carboxykinase [GTP]; IMG reference gene:2503957627; PFAM: Phosphoenolpyruvate carboxykinase YP_004411907.1 COGs: COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase; InterPro IPR000595; KEGG: cce:Ccel_1678 transcriptional regulator, Crp/Fnr family; PFAM: Cyclic nucleotide-binding domain; SMART: Cyclic nucleotide-binding domain; SPTR: Cyclic nucleotide-binding:Bacterial regulatory protein, Crp; IMG reference gene:2503957628; PFAM: Cyclic nucleotide-binding domain YP_004411908.1 COGs: COG0826 Collagenase and related protease; InterPro IPR001539; KEGG: sta:STHERM_c21690 hypothetical protein; PFAM: Peptidase U32; SPTR: uncharacterized protein; IMG reference gene:2503957629; PFAM: Collagenase; Peptidase U32 YP_004411909.1 COGs: COG0136 Aspartate-semialdehyde dehydrogenase; InterPro IPR000534:IPR005676:IPR012280; KEGG: ssm:Spirs_4027 aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase, NAD-binding; Semialdehyde dehydrogenase, dimerisation domain; PRIAM: Aspartate-semialdehyde dehydrogenase; SMART: Semialdehyde dehydrogenase, NAD-binding; SPTR: Aspartate-semialdehyde dehydrogenase; TIGRFAM: Aspartate-semialdehyde dehydrogenase, peptidoglycan lacking; IMG reference gene:2503957630; PFAM: Semialdehyde dehydrogenase, dimerisation domain; Semialdehyde dehydrogenase, NAD binding domain; TIGRFAM: aspartate-semialdehyde dehydrogenase (non-peptidoglycan organisms) YP_004411910.1 KEGG: blo:BL0787 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957632; PFAM: Protein of unknown function (DUF2974) YP_004411911.1 COGs: COG5421 Transposase; InterPro IPR002559; KEGG: cob:COB47_1677 transposase IS4 family protein; PFAM: Transposase, IS4-like; SPTR: Transposase IS4 family protein; IMG reference gene:2503957634; PFAM: Transposase DDE domain YP_004411912.1 COGs: COG0519 GMP synthase PP-ATPase domain/subunit; HAMAP: GMP synthase; InterProIPR004739:IPR001674:IPR000991:IPR004506:IPR 022955; KEGG: sat:SYN_01626 GMP synthase; PFAM: GMP synthase, C-terminal; Glutamine amidotransferase class-I, C-terminal; tRNA-specific 2-thiouridylase; PRIAM: GMP synthase (glutamine-hydrolyzing); SPTR: GMP synthase (Glutamine-hydrolyzing); TIGRFAM: GMP synthase, C-terminal; GMP synthase, N-terminal; IMG reference gene:2503957636; PFAM: Glutamine amidotransferase class-I; GMP synthase C terminal domain; NAD synthase; TIGRFAM: GMP synthase (glutamine-hydrolyzing), C-terminal domain or B subunit; GMP synthase (glutamine-hydrolyzing), N-terminal domain or A subunit YP_004411913.1 COGs: COG4720 membrane protein; InterPro IPR009825; KEGG: tko:TK2102 hypothetical protein; PFAM: Protein of unknown function DUF1393; SPTR: Hypothetical membrane protein, conserved, DUF1393 family; IMG reference gene:2503957637; PFAM: Protein of unknown function (DUF1393) YP_004411914.1 COGs: COG0619 ABC-type cobalt transport system permease component CbiQ and related transporter; InterPro IPR003339; KEGG: sti:Sthe_3088 cobalt transport protein; PFAM: Cobalt transport protein; SPTR: Cobalt transport protein; IMG reference gene:2503957638; PFAM: Cobalt transport protein YP_004411915.1 COGs: COG1123 ATPase components of various ABC-type transport systems contain duplicated ATPase; InterPro IPR003593:IPR003439; KEGG: bad:BAD_0600 ABC-type cobalt transport system, ATPase component; PFAM: ABC transporter-like; SMART: ATPase, AAA+ type, core; SPTR: uncharacterized protein; IMG reference gene:2503957639; PFAM: ABC transporter YP_004411916.1 COGs: COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase; InterPro IPR002123; KEGG: ssm:Spirs_3805 phospholipid/glycerol acyltransferase; PFAM: Phospholipid/glycerol acyltransferase; SMART: Phospholipid/glycerol acyltransferase; SPTR: 1-acyl-sn-glycerol-3-phosphate acyltransferase; IMG reference gene:2503957640; PFAM: Acyltransferase; TIGRFAM: 1-acyl-sn-glycerol-3-phosphate acyltransferases YP_004411917.1 COGs: COG1132 ABC-type multidrug transport system ATPase and permease components; InterPro IPR003593:IPR001140:IPR003439; KEGG: ssm:Spirs_4147 ABC transporter related protein; PFAM: ABC transporter-like; ABC transporter, transmembrane domain; PRIAM: Xenobiotic-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter, transmembrane region; IMG reference gene:2503957641; PFAM: ABC transporter transmembrane region; ABC transporter YP_004411918.1 COGs: COG0513 Superfamily II DNA and RNA helicase; InterPro IPR014001:IPR001650:IPR011545; KEGG: ssm:Spirs_3800 DEAD/DEAH box helicase domain protein; PFAM: DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Helicase, C-terminal; SMART: DEAD-like helicase, N-terminal; Helicase, C-terminal; SPTR: ATP-dependent RNA helicase DbpA; IMG reference gene:2503957642; PFAM: Helicase conserved C-terminal domain; DEAD/DEAH box helicase YP_004411919.1 COGs: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; InterPro IPR001544; KEGG: ssm:Spirs_0479 aminotransferase class IV; PFAM: Aminotransferase, class IV; SPTR: Aminotransferase class IV; IMG reference gene:2503957643; PFAM: Aminotransferase class IV YP_004411920.1 COGs: COG1674 DNA segregation ATPase FtsK/SpoIIIE and related protein; InterPro IPR003593:IPR018541:IPR002543; KEGG: ssm:Spirs_3823 cell division protein FtsK/SpoIIIE; PFAM: Cell divisionFtsK/SpoIIIE; DNA translocase FtsK gamma; SMART: DNA translocase FtsK gamma; ATPase, AAA+ type, core; SPTR: Predicted DNA translocase FtsK; IMG reference gene:2503957644; PFAM: Ftsk gamma domain; FtsK/SpoIIIE family YP_004411921.1 COGs: COG0357 S-adenosylmethionine-dependent methyltransferase involved in cell division; HAMAP: rRNA small subunit methyltransferase G; InterPro IPR003682; KEGG: ssm:Spirs_3828 methyltransferase GidB; PFAM: rRNA small subunit methyltransferase G; SPTR: Ribosomal RNA small subunit methyltransferase G; TIGRFAM: rRNA small subunit methyltransferase G; IMG reference gene:2503957645; PFAM: rRNA small subunit methyltransferase G; TIGRFAM: 16S rRNA (guanine(527)-N(7))-methyltransferase GidB YP_004411922.1 COGs: COG0445 NAD/FAD-utilizing enzyme apparently involved in cell division; HAMAP: Glucose-inhibited division protein A; InterPro IPR004416:IPR002218; KEGG: ssm:Spirs_3829 glucose inhibited division protein A; PFAM: Glucose-inhibited division protein A-related; SPTR: Glucose-inhibited division protein A; TIGRFAM: Glucose-inhibited division protein A; IMG reference gene:2503957646; PFAM: Glucose inhibited division protein A; TIGRFAM: glucose-inhibited division protein A YP_004411923.1 COGs: COG0486 GTPase; HAMAP: tRNA modification GTPase TrmE; InterPro IPR004520:IPR005225:IPR018948:IPR002917; KEGG: sta:STHERM_c02910 tRNA modification GTPase; PFAM: GTP-binding protein, HSR1-related; GTP-binding protein TrmE, N-terminal; SPTR: tRNA modification GTPase; TIGRFAM: tRNA modification GTPase TrmE; Small GTP-binding protein; IMG reference gene:2503957647; PFAM: GTPase of unknown function; GTP-binding protein TrmE N-terminus; TIGRFAM: tRNA modification GTPase TrmE; small GTP-binding protein domain YP_004411924.1 COGs: COG2269 Truncated possibly inactive lysyl-tRNA synthetase (class II); InterPro IPR004364; KEGG: ssm:Spirs_3665 tRNA synthetase class II (D K and N); PFAM: Aminoacyl-tRNA synthetase, class II (D/K/N); PRIAM: Lysine--tRNA ligase; SPTR: Lysyl-tRNA synthetase; IMG reference gene:2503957648; PFAM: tRNA synthetases class II (D, K and N) YP_004411925.1 COGs: COG0231 Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A); HAMAP: Translation elongation factor P; InterPro IPR015365:IPR011768:IPR013185:IPR001059; KEGG: ssm:Spirs_3666 translation elongation factor P; PFAM: Elongation factor P, C-terminal; Translation elongation factor, KOW-like; Translation elongation factor P/YeiP, central; SMART: Elongation factor P, C-terminal; SPTR: uncharacterized protein; TIGRFAM: Translation elongation factor P; IMG reference gene:2503957649; PFAM: Elongation factor P, C-terminal; Elongation factor P (EF-P) KOW-like domain; Elongation factor P (EF-P) OB domain; TIGRFAM: translation elongation factor P YP_004411926.1 COGs: COG1509 Lysine 2 3-aminomutase; InterPro IPR003739:IPR007197; KEGG: afw:Anae109_1316 lysine 2,3-aminomutase YodO family protein; PFAM: Radical SAM; PRIAM: Lysine 2,3-aminomutase; SPTR: Lysine 2,3-aminomutase YodO family protein; TIGRFAM: Conserved hyprothetical protein CHP00238, KamA; IMG reference gene:2503957650; PFAM: Radical SAM superfamily; TIGRFAM: KamA family protein YP_004411927.1 COGs: COG2211 Na+/melibiose symporter and related transporter; InterPro IPR011701; KEGG: ssm:Spirs_3673 major facilitator superfamily MFS_1; PFAM: Major facilitator superfamily MFS-1; SPTR: Transporter, ; IMG reference gene:2503957651; PFAM: Major Facilitator Superfamily YP_004411928.1 InterPro IPR012506; KEGG: sgr:SGR_5669 hypothetical protein; PFAM: YhhN-like; SPTR: YhhN family protein; IMG reference gene:2503957652; PFAM: YhhN-like protein YP_004411929.1 InterPro IPR011493; KEGG: hwa:HQ1081A halomucin; SPTR: Halomucin; IMG reference gene:2503957653 YP_004411930.1 KEGG: pfa:PF10_0351 probable protein; SPTR: Probable protein; IMG reference gene:2503957654 YP_004411931.1 COGs: COG0237 Dephospho-CoA kinase; HAMAP: Dephospho-CoA kinase; InterPro IPR001977; KEGG: ssm:Spirs_3675 dephospho-CoA kinase; PFAM: Dephospho-CoA kinase; SPTR: Dephospho-CoA kinase; TIGRFAM: Dephospho-CoA kinase; IMG reference gene:2503957655; PFAM: Dephospho-CoA kinase; TIGRFAM: dephospho-CoA kinase YP_004411932.1 COGs: COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains; InterProIPR002421:IPR008918:IPR002562:IPR001098:IPR 018320:IPR020046:IPR020047; KEGG: ssm:Spirs_3676 DNA polymerase I; PFAM: DNA-directed DNA polymerase, family A, palm domain; 5'-3' exonuclease, alpha-helical arch, N-terminal; 5'-3' exonuclease, SAM-fold domain; 3'-5' exonuclease; PRIAM: DNA-directed DNA polymerase; SMART: 5'-3' exonuclease, N-terminal; Helix-hairpin-helix motif, class 2; 3'-5' exonuclease; DNA-directed DNA polymerase, family A, palm domain; SPTR: DNA polymerase I; TIGRFAM: DNA polymerase 1; IMG reference gene:2503957656; PFAM: 5'-3' exonuclease, C-terminal SAM fold; 3'-5' exonuclease; 5'-3' exonuclease, N-terminal resolvase-like domain; DNA polymerase A; TIGRFAM: DNA polymerase I YP_004411933.1 COGs: COG1235 Metal-dependent hydrolase of the beta-lactamase superfamily I; InterPro IPR001279; KEGG: ssm:Spirs_3682 beta-lactamase domain protein; PFAM: Beta-lactamase-like; SMART: Beta-lactamase-like; SPTR: uncharacterized protein; IMG reference gene:2503957657; PFAM: Metallo-beta-lactamase superfamily YP_004411934.1 KEGG: ani:AN1767.2 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957658 YP_004411935.1 KEGG: gem:GM21_0672 FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SPTR: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; IMG reference gene:2503957659 YP_004411936.1 KEGG: pic:PICST_57741 hypothetical protein; SPTR: Probable outer membrane porin; IMG reference gene:2503957660 YP_004411937.1 COGs: COG0171 NAD synthase; InterPro IPR003694:IPR003010:IPR022310; KEGG: ols:Olsu_0182 NAD+ synthetase; PFAM: NAD/GMP synthase; Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; PRIAM: NAD(+) synthase (glutamine-hydrolyzing); SPTR: uncharacterized protein; TIGRFAM: NAD synthase; IMG reference gene:2503957661; PFAM: NAD synthase; Carbon-nitrogen hydrolase; TIGRFAM: NAD+ synthetase YP_004411938.1 COGs: COG2265 SAM-dependent methyltransferase related to tRNA (uracil-5-)-methyltransferase; InterPro IPR010280; KEGG: aca:ACP_2578 23S rRNA (uracil-5-)-methyltransferase; PFAM: (Uracil-5)-methyltransferase; SPTR: tRNA (Uracil-5-)-methyltransferase; IMG reference gene:2503957662; PFAM: tRNA (Uracil-5-)-methyltransferase; Met-10+ like-protein YP_004411939.1 COGs: COG1164 Oligoendopeptidase F; InterPro IPR013647:IPR001567; KEGG: tde:TDE2001 oligoendopeptidase F, PFAM: Peptidase M3A/M3B, thimet/oligopeptidase F; Peptidase M3B, oligopeptidase F, N-terminal; SPTR: Oligoendopeptidase F, ; IMG reference gene:2503957663; PFAM: Oligopeptidase F; Peptidase M3; TIGRFAM: oligoendopeptidase, pepF/M3 family YP_004411940.1 COGs: COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains; InterPro IPR001789:IPR003593:IPR002078:IPR002197; KEGG: ssm:Spirs_0494 two component, sigma54 specific, transcriptional regulator, fis family; PFAM: RNA polymerase sigma factor 54, interaction; Signal transduction response regulator, receiver domain; Helix-turn-helix, Fis-type; SMART: Signal transduction response regulator, receiver domain; ATPase, AAA+ type, core; SPTR: Two component, sigma54 specific, transcriptional regulator, Fis family; IMG reference gene:2503957664; PFAM: Response regulator receiver domain; Bacterial regulatory protein, Fis family; Sigma-54 interaction domain YP_004411941.1 COGs: COG0642 Signal transduction histidine kinase; InterPro IPR003661:IPR003594; KEGG: ssm:Spirs_0495 integral membrane sensor signal transduction histidine kinase; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; SMART: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; SPTR: Sensor histidine kinase; IMG reference gene:2503957665; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain YP_004411942.1 COGs: COG0577 ABC-type antimicrobial peptide transport system permease component; InterPro IPR003838; KEGG: sta:STHERM_c10100 hypothetical protein; PFAM: Domain of unknown function DUF214, ABC transporter permease; SPTR: uncharacterized protein; IMG reference gene:2503957666; PFAM: Predicted permease YP_004411943.1 COGs: COG1136 ABC-type antimicrobial peptide transport system ATPase component; InterPro IPR003593:IPR003439; KEGG: cpc:Cpar_0807 ABC transporter related; PFAM: ABC transporter-like; PRIAM: Phosphonate-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter related; IMG reference gene:2503957667; PFAM: ABC transporter YP_004411944.1 COGs: COG0845 Membrane-fusion protein; InterPro IPR006143; KEGG: tde:TDE2284 RND family efflux transporter MFP subunit; PFAM: Secretion protein HlyD; SPTR: Efflux transporter, RND family, MFP subunit; TIGRFAM: Secretion protein HlyD; IMG reference gene:2503957668; PFAM: HlyD family secretion protein; TIGRFAM: RND family efflux transporter, MFP subunit YP_004411945.1 KEGG: tgu:100231991 dual specificity phosphatase 27 (); SPTR: Outer membrane efflux protein; IMG reference gene:2503957669 YP_004411946.1 COGs: COG1281 Disulfide bond chaperones of the HSP33 family; InterPro IPR000397; KEGG: ssm:Spirs_0341 HSP33 protein; PFAM: Heat shock protein Hsp33 protein; SPTR: Chaperonin HslO; IMG reference gene:2503957670; PFAM: Hsp33 protein YP_004411947.1 COGs: COG0116 N6-adenine-specific DNA methylase; HAMAP: S-adenosyl-L-dependent RNA methyltransferase, bacteria; InterPro IPR004114:IPR000241:IPR017244; KEGG: alv:Alvin_2173 RNA methylase; PFAM: RNA methylase; THUMP; PRIAM: rRNA (guanine-N(2)-)-methyltransferase; SMART: THUMP; SPTR: Ribosomal RNA large subunit methyltransferase L; IMG reference gene:2503957671; PFAM: RNA methylase UPF0020; S-adenosylmethionine-dependent methyltransferase; THUMP domain YP_004411948.1 COGs: COG1970 Large-conductance mechanosensitive channel; HAMAP: Large-conductance mechanosensitive channel; InterPro IPR001185; KEGG: cco:CCC13826_1549 large-conductance mechanosensitive channel; PFAM: Large-conductance mechanosensitive channel; SPTR: Large-conductance mechanosensitive channel; TIGRFAM: Large-conductance mechanosensitive channel; IMG reference gene:2503957672; PFAM: Large-conductance mechanosensitive channel, MscL; TIGRFAM: large conductance mechanosensitive channel protein YP_004411949.1 COGs: COG2184 Protein involved in cell division; InterPro IPR003812; KEGG: hmo:HM1_0604 cell filamentation protein fic, PFAM: Filamentation induced by cAMP/death on curing-related; SPTR: Cell filamentation protein fic, ; IMG reference gene:2503957673; PFAM: Fic/DOC family YP_004411950.1 KEGG: alv:Alvin_0840 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957674 YP_004411951.1 COGs: COG1940 Transcriptional regulator/sugar kinase; InterPro IPR000600; KEGG: ssm:Spirs_1400 ROK family protein; PFAM: ROK; SPTR: transcriptional regulator; IMG reference gene:2503957675; PFAM: ROK family YP_004411952.1 COGs: COG3681 conserved hypothetical protein; HAMAP: Uncharacterised protein family UPF0597; InterPro IPR021144; KEGG: bpo:BP951000_1867 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957677; PFAM: Serine dehydratase alpha chain YP_004411953.1 KEGG: osa:4351396 hypothetical protein; SPTR: M18 family aminopeptidase; IMG reference gene:2503957678 YP_004411954.1 COGs: COG0395 ABC-type sugar transport system permease component; InterPro IPR000515; KEGG: csh:Closa_1292 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: uncharacterized protein; IMG reference gene:2503957679; PFAM: Binding-protein-dependent transport system inner membrane component YP_004411955.1 COGs: COG1175 ABC-type sugar transport systems permease components; InterPro IPR000515; KEGG: csh:Closa_1291 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Transport protein; IMG reference gene:2503957680; PFAM: Binding-protein-dependent transport system inner membrane component YP_004411956.1 COGs: COG1653 ABC-type sugar transport system periplasmic component; InterPro IPR006059; KEGG: csh:Closa_1290 extracellular solute-binding protein family 1; PFAM: Bacterial extracellular solute-binding, family 1; SPTR: uncharacterized protein; IMG reference gene:2503957681; PFAM: Bacterial extracellular solute-binding protein YP_004411957.1 KEGG: csh:Closa_1289 uroporphyrinogen-III decarboxylase-like protein; SPTR: uncharacterized protein; IMG reference gene:2503957682; PFAM: Uroporphyrinogen decarboxylase (URO-D) YP_004411958.1 COGs: COG2964 conserved hypothetical protein; InterPro IPR013559; KEGG: hiq:CGSHiGG_06150 hypothetical protein; PFAM: YheO-like; SPTR: uncharacterized protein; IMG reference gene:2503957683; PFAM: YheO-like PAS domain YP_004411959.1 COGs: COG4821 Uncharacterized protein containing SIS (Sugar ISomerase) phosphosugar binding domain; KEGG: tpe:Tpen_1090 hypothetical protein; SPTR: Phosphoheptose isomerase, ; IMG reference gene:2503957684 YP_004411960.1 KEGG: hmg:100208216 similar to Collagen alpha-5(VI) chain; SPTR: Hemagglutinin-neuraminidase; IMG reference gene:2503957685 YP_004411961.1 KEGG: aoe:Clos_2735 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957686 YP_004411962.1 KEGG: cbe:Cbei_1260 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957687 YP_004411963.1 COGs: COG0180 Tryptophanyl-tRNA synthetase; InterPro IPR002306:IPR002305; KEGG: esi:Exig_2059 tryptophanyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class Ib; PRIAM: Tryptophan--tRNA ligase; SPTR: Tryptophan--tRNA ligase; TIGRFAM: Tryptophanyl-tRNA synthetase, class Ib; IMG reference gene:2503957688; PFAM: tRNA synthetases class I (W and Y); TIGRFAM: tryptophanyl-tRNA synthetase YP_004411964.1 COGs: COG0474 Cation transport ATPase; InterProIPR004014:IPR006415:IPR001757:IPR008250:IPR 005834:IPR006068; KEGG: acl:ACL_1281 magnesium transporting ATPase, P-type; PFAM: ATPase, P-type, ATPase-associated domain; ATPase, P-type cation-transporter, N-terminal; Haloacid dehalogenase-like hydrolase; ATPase, P-type cation-transporter, C-terminal; PRIAM: Magnesium-importing ATPase; SMART: ATPase, P-type cation-transporter, N-terminal; SPTR: Magnesium transporting ATPase, P-type; TIGRFAM: ATPase, P-type, magnesium-translocating; ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter; IMG reference gene:2503957689; PFAM: E1-E2 ATPase; Cation transporting ATPase, C-terminus; Cation transporter/ATPase, N-terminus; haloacid dehalogenase-like hydrolase; TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; magnesium-translocating P-type ATPase YP_004411965.1 COGs: COG1912 conserved hypothetical protein; KEGG: ssm:Spirs_0807 peptidoglycan-binding lysin domain protein; SPTR: uncharacterized protein; IMG reference gene:2503957690; PFAM: S-adenosyl-l-methionine hydroxide adenosyltransferase; Tyrosine phosphatase YP_004411966.1 COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR000277; KEGG: cth:Cthe_2799 cystathionine gamma-synthase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; PRIAM: Cystathionine gamma-lyase; SPTR: Cystathionine gamma-synthase; IMG reference gene:2503957692; PFAM: Cys/Met metabolism PLP-dependent enzyme YP_004411967.1 COGs: COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain; InterPro IPR001789:IPR018060:IPR000005; KEGG: cpy:Cphy_0293 two component AraC family transcriptional regulator; PFAM: Signal transduction response regulator, receiver domain; HTH transcriptional regulator, AraC; SMART: Signal transduction response regulator, receiver domain; Helix-turn-helix, AraC type, DNA binding domain; SPTR: Two component transcriptional regulator, AraC family; IMG reference gene:2503957693; PFAM: Response regulator receiver domain; Bacterial regulatory helix-turn-helix proteins, AraC family YP_004411968.1 COGs: COG2972 signal transduction protein with a C-terminal ATPase domain; InterPro IPR003660:IPR003594:IPR010559; KEGG: csh:Closa_1925 integral membrane sensor signal transduction histidine kinase; PFAM: Signal transduction histidine kinase, internal region; HAMP linker domain; ATPase-like, ATP-binding domain; SMART: ATPase-like, ATP-binding domain; HAMP linker domain; SPTR: Sensor histidine kinase; IMG reference gene:2503957694; PFAM: Histidine kinase; HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase YP_004411969.1 COGs: COG1653 ABC-type sugar transport system periplasmic component; InterPro IPR006059; KEGG: cpy:Cphy_0291 extracellular solute-binding protein; PFAM: Bacterial extracellular solute-binding, family 1; SPTR: Extracellular solute-binding protein family 1; IMG reference gene:2503957695; PFAM: Bacterial extracellular solute-binding protein YP_004411970.1 COGs: COG1175 ABC-type sugar transport systems permease components; InterPro IPR000515; KEGG: cpy:Cphy_0290 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Transmembrane permease MsmF; IMG reference gene:2503957696; PFAM: Binding-protein-dependent transport system inner membrane component YP_004411971.1 COGs: COG0395 ABC-type sugar transport system permease component; InterPro IPR000515; KEGG: cpy:Cphy_0289 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Binding-protein-dependent transport systems inner membrane component; IMG reference gene:2503957697; PFAM: Binding-protein-dependent transport system inner membrane component YP_004411972.1 InterPro IPR012480; KEGG: cpy:Cphy_3022 heparinase II/III family protein; PFAM: Heparinase II/III-like; SPTR: Heparinase II/III family protein; IMG reference gene:2503957698; PFAM: Heparinase II/III-like protein YP_004411973.1 COGs: COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase); InterPro IPR002198; KEGG: cce:Ccel_2618 short-chain dehydrogenase/reductase SDR; PFAM: Short-chain dehydrogenase/reductase SDR; PRIAM: 3-oxoacyl-[acyl-carrier-protein] reductase; SPTR: Short-chain dehydrogenase/reductase SDR; IMG reference gene:2503957699; PFAM: short chain dehydrogenase YP_004411974.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR011110; KEGG: aeh:Mlg_2687 regulator of chromosome condensation, RCC1; SPTR: uncharacterized protein; IMG reference gene:2503957700; PFAM: Regulator of chromosome condensation (RCC1) repeat YP_004411975.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR011110; KEGG: aeh:Mlg_2687 regulator of chromosome condensation, RCC1; SPTR: uncharacterized protein; IMG reference gene:2503957701; PFAM: Listeria-Bacteroides repeat domain (List_Bact_rpt); Regulator of chromosome condensation (RCC1) repeat YP_004411976.1 COGs: COG3214 conserved hypothetical protein; InterPro IPR009351; KEGG: bbe:BBR47_29660 hypothetical protein; PFAM: Protein of unknown function DUF1006; SPTR: uncharacterized protein; IMG reference gene:2503957702; PFAM: Protein of unknown function (DUF1006) YP_004411977.1 COGs: COG1912 conserved hypothetical protein; InterPro IPR002747; KEGG: sga:GALLO_1836 hypothetical protein; PFAM: Protein of unknown function DUF62; SPTR: Molybdate/tungstate binding protein; IMG reference gene:2503957703; PFAM: S-adenosyl-l-methionine hydroxide adenosyltransferase YP_004411978.1 COGs: COG1912 conserved hypothetical protein; InterPro IPR002747; KEGG: lbu:LBUL_1585 hypothetical protein; PFAM: Protein of unknown function DUF62; SPTR: Molybdate/tungstate binding protein; IMG reference gene:2503957704; PFAM: S-adenosyl-l-methionine hydroxide adenosyltransferase YP_004411979.1 COGs: COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylase; InterPro IPR010964:IPR002933:IPR011650; KEGG: gtn:GTNG_2735 Xaa-His dipeptidase; PFAM: Peptidase M20; Peptidase M20, dimerisation; SPTR: M20 family peptidase PepV; TIGRFAM: Peptidase M20A, peptidase V-related; IMG reference gene:2503957705; PFAM: Peptidase M20/M25/M40; Peptidase dimerisation domain; TIGRFAM: dipeptidase YP_004411980.1 COGs: COG0619 ABC-type cobalt transport system permease component CbiQ and related transporter; InterPro IPR003339; KEGG: ssm:Spirs_3591 cobalt transport protein; PFAM: Cobalt transport protein; SPTR: uncharacterized protein; IMG reference gene:2503957706; PFAM: Cobalt transport protein YP_004411981.1 COGs: COG1123 ATPase components of various ABC-type transport systems contain duplicated ATPase; InterPro IPR003593:IPR003439; KEGG: ssm:Spirs_3590 ABC transporter related protein; PFAM: ABC transporter-like; PRIAM: Monosaccharide-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter domain-containing protein; IMG reference gene:2503957707; PFAM: ABC transporter; ATP-binding cassette cobalt transporter YP_004411982.1 InterPro IPR009825; KEGG: ssm:Spirs_3589 protein of unknown function DUF1393; PFAM: Protein of unknown function DUF1393; SPTR: Substrate-specific component MtsA of methionine-regulated ECF transporter; IMG reference gene:2503957708; PFAM: Protein of unknown function (DUF1393) YP_004411983.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR011110; KEGG: aeh:Mlg_2687 regulator of chromosome condensation, RCC1; SPTR: uncharacterized protein; IMG reference gene:2503957709; PFAM: Regulator of chromosome condensation (RCC1) repeat YP_004411984.1 COGs: COG4211 ABC-type glucose/galactose transport system permease component; InterPro IPR001851; KEGG: tde:TDE2215 galactoside ABC transporter, permease, PFAM: ABC transporter permease; SPTR: galactoside ABC transporter, permease; IMG reference gene:2503957710; PFAM: Branched-chain amino acid transport system / permease component YP_004411985.1 COGs: COG1129 ABC-type sugar transport system ATPase component; InterPro IPR003593:IPR003439; KEGG: tde:TDE2216 galactoside ABC transporter, ATP-binding protein; PFAM: ABC transporter-like; PRIAM: Monosaccharide-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: Galactose/methyl galactoside import ATP-binding protein MglA; IMG reference gene:2503957711; PFAM: ABC transporter YP_004411986.1 COGs: COG1879 ABC-type sugar transport system periplasmic component; KEGG: tde:TDE2217 galactose/glucose-binding lipoprotein; SPTR: Galactose/glucose-binding lipoprotein; IMG reference gene:2503957712 YP_004411987.1 COGs: COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain; InterPro IPR001789:IPR018060:IPR000005; KEGG: ccb:Clocel_3842 two component transcriptional regulator, AraC family; PFAM: Signal transduction response regulator, receiver domain; HTH transcriptional regulator, AraC; SMART: Helix-turn-helix, AraC type, DNA binding domain; Signal transduction response regulator, receiver domain; SPTR: Two component transcriptional regulator, AraC family; IMG reference gene:2503957713; PFAM: Response regulator receiver domain; Bacterial regulatory helix-turn-helix proteins, AraC family YP_004411988.1 COGs: COG2972 signal transduction protein with a C-terminal ATPase domain; InterPro IPR003660:IPR003594:IPR004010:IPR010559; KEGG: ccb:Clocel_3841 multi-sensor signal transduction histidine kinase; PFAM: Signal transduction histidine kinase, internal region; HAMP linker domain; Cache; ATPase-like, ATP-binding domain; SMART: ATPase-like, ATP-binding domain; HAMP linker domain; SPTR: Multi-sensor signal transduction histidine kinase; IMG reference gene:2503957714; PFAM: Histidine kinase; HAMP domain; Cache domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase YP_004411989.1 COGs: COG1879 ABC-type sugar transport system periplasmic component; KEGG: cpy:Cphy_2251 periplasmic binding protein/LacI transcriptional regulator; SPTR: uncharacterized protein; IMG reference gene:2503957715 YP_004411990.1 COGs: COG1879 ABC-type sugar transport system periplasmic component; KEGG: bbe:BBR47_06800 D-galactose ABC transporter substrate binding protein precursor; SPTR: D-galactose ABC transporter substrate binding protein; IMG reference gene:2503957716 YP_004411991.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR013378:IPR011110:IPR000408; KEGG: aeh:Mlg_2687 regulator of chromosome condensation, RCC1; PFAM: Listeria/Bacterioides repeat; Two component regulator propeller; Regulator of chromosome condensation, RCC1; SPTR: Alpha-tubulin suppressor and related RCC1 domain-containing protein-like protein; IMG reference gene:2503957717; PFAM: Listeria-Bacteroides repeat domain (List_Bact_rpt); Regulator of chromosome condensation (RCC1) repeat YP_004411992.1 COGs: COG0765 ABC-type amino acid transport system permease component; InterPro IPR010065:IPR000515; KEGG: dhd:Dhaf_1045 polar amino acid ABC transporter, inner membrane subunit; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: uncharacterized protein; TIGRFAM: Amino acid ABC transporter, permease, 3-TM domain, His/Glu/Gln/Arg/opine family; IMG reference gene:2503957718; PFAM: Binding-protein-dependent transport system inner membrane component; TIGRFAM: amine acid ABC transporter, permease, 3-TM region, His/Glu/Gln/Arg/opine family YP_004411993.1 COGs: COG0765 ABC-type amino acid transport system permease component; InterPro IPR010065:IPR000515; KEGG: dsy:DSY4276 hypothetical protein; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: uncharacterized protein; TIGRFAM: Amino acid ABC transporter, permease, 3-TM domain, His/Glu/Gln/Arg/opine family; IMG reference gene:2503957719; PFAM: Binding-protein-dependent transport system inner membrane component; TIGRFAM: amine acid ABC transporter, permease, 3-TM region, His/Glu/Gln/Arg/opine family YP_004411994.1 COGs: COG0834 ABC-type amino acid transport/signal transduction systems periplasmic component/domain; InterPro IPR001638; KEGG: dhd:Dhaf_1043 extracellular solute-binding protein family 3; PFAM: Extracellular solute-binding protein, family 3; SMART: Extracellular solute-binding protein, family 3; SPTR: uncharacterized protein; IMG reference gene:2503957720; PFAM: Bacterial extracellular solute-binding proteins, family 3 YP_004411995.1 COGs: COG1126 ABC-type polar amino acid transport system ATPase component; InterPro IPR003593:IPR003439; KEGG: toc:Toce_1570 amino acid ABC transporter ATP-binding protein, PAAT family; PFAM: ABC transporter-like; PRIAM: Phosphonate-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: Amino acid ABC transporter ATP-binding protein, PAAT family; IMG reference gene:2503957721; PFAM: ABC transporter YP_004411996.1 COGs: COG1854 LuxS protein involved in autoinducer AI2 synthesis; InterPro IPR003815; KEGG: bpb:bpr_I0033 S-ribosylhomocysteinase LuxS; PFAM: S-ribosylhomocysteinase (LuxS); PRIAM: S-ribosylhomocysteine lyase; SPTR: S-ribosylhomocysteinase LuxS; IMG reference gene:2503957722; PFAM: S-Ribosylhomocysteinase (LuxS) YP_004411997.1 COGs: COG0775 Nucleoside phosphorylase; InterPro IPR010049:IPR000845; KEGG: ppy:PPE_03405 MTA/SAH nucleosidase (5'-methylthioadenosine nucleosidase); PFAM: Nucleoside phosphorylase domain; PRIAM: Adenosylhomocysteine nucleosidase; SPTR: MTA/SAH nucleosidase (5'-methylthioadenosine nucleosidase); TIGRFAM: MTA/SAH nucleosidase; IMG reference gene:2503957723; PFAM: Phosphorylase superfamily; TIGRFAM: 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase YP_004411998.1 KEGG: mxa:MXAN_2924 general secretion pathway protein E; IMG reference gene:2503957724 YP_004411999.1 COGs: COG1175 ABC-type sugar transport systems permease components; InterPro IPR000515; KEGG: cac:CA_C0427 glycerol-3-phosphate ABC-transporter, permease component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Binding-protein-dependent transport systems inner membrane component; IMG reference gene:2503957725; PFAM: Binding-protein-dependent transport system inner membrane component YP_004412000.1 COGs: COG0395 ABC-type sugar transport system permease component; InterPro IPR000515; KEGG: cac:CA_C0428 sugar permease; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Binding-protein-dependent transport systems inner membrane component; IMG reference gene:2503957726; PFAM: Binding-protein-dependent transport system inner membrane component YP_004412001.1 COGs: COG1653 ABC-type sugar transport system periplasmic component; InterPro IPR006059; KEGG: apr:Apre_0061 extracellular solute-binding protein family 1; PFAM: Bacterial extracellular solute-binding, family 1; SPTR: Extracellular solute-binding protein family 1; IMG reference gene:2503957727; PFAM: Bacterial extracellular solute-binding protein YP_004412002.1 COGs: COG1082 Sugar phosphate isomerase/epimerase; InterPro IPR012307; KEGG: toc:Toce_0893 xylose isomerase domain protein TIM barrel; PFAM: Xylose isomerase, TIM barrel domain; SPTR: Xylose isomerase domain protein TIM barrel; IMG reference gene:2503957728; PFAM: Xylose isomerase-like TIM barrel YP_004412003.1 COGs: COG0789 transcriptional regulator protein; InterPro IPR000551; KEGG: seq:SZO_16670 MerR family regulatory protein; PFAM: HTH transcriptional regulator, MerR; SMART: HTH transcriptional regulator, MerR; SPTR: MerR family regulatory protein; IMG reference gene:2503957729; PFAM: MerR family regulatory protein YP_004412004.1 COGs: COG2003 DNA repair protein; InterPro IPR001405; KEGG: ssm:Spirs_3489 DNA repair protein RadC; PFAM: Uncharacterised protein family UPF0758; SPTR: DNA repair protein; TIGRFAM: Uncharacterised protein family UPF0758; IMG reference gene:2503957730; PFAM: Protein of unknown function (DUF2466); TIGRFAM: DNA repair protein radc YP_004412005.1 COGs: COG0053 Co/Zn/Cd cation transporter; InterPro IPR002524; KEGG: cbf:CLI_1359 cation efflux family protein; PFAM: Cation efflux protein; SPTR: Cation diffusion facilitator family transporter; TIGRFAM: Cation efflux protein; IMG reference gene:2503957731; PFAM: Cation efflux family; TIGRFAM: cation diffusion facilitator family transporter YP_004412006.1 COGs: COG0139 Phosphoribosyl-AMP cyclohydrolase; HAMAP: Phosphoribosyl-ATP pyrophosphohydrolase; Histidine biosynthesis bifunctional protein HisIE; InterPro IPR008179:IPR002496:IPR021130:IPR023019; KEGG: cpi:Cpin_1832 phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase-like; Phosphoribosyl-AMP cyclohydrolase; SPTR: Phosphoribosyl-ATP diphosphatase; TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; IMG reference gene:2503957732; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; Phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase YP_004412007.1 COGs: COG0107 Imidazoleglycerol-phosphate synthase; HAMAP: Histidine biosynthesis, HisF; InterPro IPR004651:IPR006062; KEGG: cpi:Cpin_1831 imidazoleglycerol phosphate synthase, cyclase subunit; PFAM: Histidine biosynthesis; PRIAM:1-(5-phosphoribosyl)-5-((5-phosphoribosylamin o)methylideneamino)imidazole-4-carboxamideisomerase; SPTR: Imidazole glycerol phosphate synthase subunit hisF; TIGRFAM: Histidine biosynthesis, HisF; IMG reference gene:2503957733; PFAM: Histidine biosynthesis protein; TIGRFAM: imidazoleglycerol phosphate synthase, cyclase subunit YP_004412008.1 COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; HAMAP: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; InterPro IPR006062:IPR023016; KEGG: chu:CHU_1272 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis; PRIAM:1-(5-phosphoribosyl)-5-((5-phosphoribosylamin o)methylideneamino)imidazole-4-carboxamideisomerase; SPTR:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; IMG reference gene:2503957734; PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase YP_004412009.1 COGs: COG0118 Glutamine amidotransferase; HAMAP: Imidazole glycerol phosphate synthase, subunit H; InterPro IPR010139:IPR000991; KEGG: dfe:Dfer_4237 imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; PFAM: Glutamine amidotransferase class-I, C-terminal; SPTR: Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; TIGRFAM: Imidazole glycerol phosphate synthase, subunit H; IMG reference gene:2503957735; PFAM: Glutamine amidotransferase class-I; TIGRFAM: imidazole glycerol phosphate synthase, glutamine amidotransferase subunit YP_004412010.1 COGs: COG0131 Imidazoleglycerol-phosphate dehydratase; HAMAP: Imidazoleglycerol-phosphate dehydratase; InterPro IPR006543:IPR006549:IPR000807; KEGG: chu:CHU_1270 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; PFAM: Imidazoleglycerol-phosphate dehydratase; PRIAM: Histidinol-phosphatase; SPTR: Bifunctional protein: histidinol-phosphatase; imidazoleglycerol-phosphate dehydratase; TIGRFAM: Histidinol-phosphate phosphatase; HAD-superfamily hydrolase, subfamily IIIA; IMG reference gene:2503957736; PFAM: Imidazoleglycerol-phosphate dehydratase; TIGRFAM: HAD-superfamily hydrolase, subfamily IIIA; histidinol-phosphate phosphatase domain; histidinol-phosphatase YP_004412011.1 COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; HAMAP: Histidinol-phosphate aminotransferase; InterPro IPR005861:IPR004839; KEGG: pdi:BDI_0968 histidinol-phosphate aminotransferase; PFAM: Aminotransferase, class I/classII; PRIAM: Histidinol-phosphate transaminase; SPTR: Histidinol-phosphate aminotransferase; TIGRFAM: Histidinol-phosphate aminotransferase; IMG reference gene:2503957737; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase YP_004412012.1 COGs: COG0141 Histidinol dehydrogenase; HAMAP: Histidinol dehydrogenase, prokaryotic-type; InterPro IPR012131; KEGG: pdi:BDI_0967 histidinol dehydrogenase; PFAM: Histidinol dehydrogenase, prokaryotic-type; PRIAM: Histidinol dehydrogenase; SPTR: Histidinol dehydrogenase; TIGRFAM: Histidinol dehydrogenase, prokaryotic-type; IMG reference gene:2503957738; PFAM: Histidinol dehydrogenase; TIGRFAM: histidinol dehydrogenase YP_004412013.1 COGs: COG0040 ATP phosphoribosyltransferase; HAMAP: Histidine biosynthesis HisG, ATP phosphoribosyltransferase, subgroup; InterPro IPR013820:IPR013115:IPR020621; KEGG: dfe:Dfer_1142 ATP phosphoribosyltransferase; PFAM: ATP phosphoribosyltransferase, catalytic domain; Histidine biosynthesis HisG, C-terminal; PRIAM: ATP phosphoribosyltransferase; SPTR: ATP phosphoribosyltransferase; TIGRFAM: ATP phosphoribosyltransferase, catalytic domain; Histidine biosynthesis HisG, C-terminal; IMG reference gene:2503957739; PFAM: HisG, C-terminal domain; ATP phosphoribosyltransferase; TIGRFAM: ATP phosphoribosyltransferase, C-terminal domain; ATP phosphoribosyltransferase YP_004412014.1 KEGG: sti:Sthe_2657 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957740 YP_004412015.1 COGs: COG1011 hydrolase (HAD superfamily); InterPro IPR011951:IPR006439:IPR005834; KEGG: rcu:RCOM_2074390 5'-nucleotidase yjjG, PFAM: Haloacid dehalogenase-like hydrolase; PRIAM: 5'-nucleotidase; SPTR: 5'-nucleotidase yjjG, ; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, YjjG/YfnB; HAD-superfamily hydrolase, subfamily IA, variant 1; IMG reference gene:2503957741; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; HAD superfamily (subfamily IA) hydrolase, TIGR02254 YP_004412016.1 COGs: COG0545 FKBP-type peptidyl-prolyl cis-trans isomerase 1; InterPro IPR000774:IPR001179; KEGG: dol:Dole_1577 peptidylprolyl isomerase FKBP-type; PFAM: Peptidyl-prolyl cis-trans isomerase, FKBP-type, N-terminal; Peptidyl-prolyl cis-trans isomerase, FKBP-type; SPTR: Peptidyl-prolyl cis-trans isomerase; IMG reference gene:2503957742; PFAM: FKBP-type peptidyl-prolyl cis-trans isomerase; Domain amino terminal to FKBP-type peptidyl-prolyl isomerase YP_004412017.1 COGs: COG0128 5-enolpyruvylshikimate-3-phosphate synthase; HAMAP: 3-phosphoshikimate 1-carboxyvinyltransferase; InterPro IPR006264:IPR001986; KEGG: ssm:Spirs_3939 3-phosphoshikimate 1-carboxyvinyltransferase; PFAM: Enolpyruvate transferase domain; PRIAM: 3-phosphoshikimate 1-carboxyvinyltransferase; SPTR: 3-phosphoshikimate 1-carboxyvinyltransferase; TIGRFAM: 3-phosphoshikimate 1-carboxyvinyltransferase; IMG reference gene:2503957743; PFAM: EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); TIGRFAM: 3-phosphoshikimate 1-carboxyvinyltransferase YP_004412018.1 COGs: COG2008 Threonine aldolase; InterPro IPR001597; KEGG: ssm:Spirs_3940 threonine aldolase; PFAM: Aromatic amino acid beta-eliminating lyase/threonine aldolase; PRIAM: Threonine aldolase; SPTR: Threonine aldolase; IMG reference gene:2503957744; PFAM: Beta-eliminating lyase YP_004412019.1 COGs: COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities; InterPro IPR004839; KEGG: cbi:CLJ_B1515 aminotransferase, classes I and II; PFAM: Aminotransferase, class I/classII; PRIAM: Cystathionine beta-lyase; SPTR: Aminotransferase, classes I and II; IMG reference gene:2503957745; PFAM: Aminotransferase class I and II YP_004412020.1 COGs: COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains); InterPro IPR000212; KEGG: ssm:Spirs_3944 UvrD/REP helicase; PFAM: DNA helicase, UvrD/REP type; SPTR: ATP-dependent DNA helicase, UvrD/Rep family; IMG reference gene:2503957746; PFAM: UvrD/REP helicase YP_004412021.1 KEGG: ssm:Spirs_3945 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957747 YP_004412022.1 InterPro IPR003675; KEGG: rrs:RoseRS_4016 abortive infection protein; PFAM: Abortive infection protein; SPTR: Abortive infection protein; IMG reference gene:2503957748; PFAM: CAAX amino terminal protease YP_004412023.1 COGs: COG1864 DNA/RNA endonuclease G NUC1; InterPro IPR001604:IPR020821; KEGG: cts:Ctha_1807 DNA/RNA non-specific endonuclease; PFAM: DNA/RNA non-specific endonuclease; SMART: DNA/RNA non-specific endonuclease; Extracellular Endonuclease, subunit A; SPTR: DNA/RNA non-specific endonuclease; IMG reference gene:2503957749; PFAM: DNA/RNA non-specific endonuclease YP_004412024.1 COGs: COG0371 Glycerol dehydrogenase; InterPro IPR002658; KEGG: bcv:Bcav_1503 glycerol-1-phosphate dehydrogenase (NAD(P)(+)); PFAM: 3-dehydroquinate synthase AroB; PRIAM: Glycerol-1-phosphate dehydrogenase (NAD(P)(+)); SPTR: Glycerol-1-phosphate dehydrogenase (NAD(P)(+)); IMG reference gene:2503957750; PFAM: 3-dehydroquinate synthase YP_004412025.1 IMG reference gene:2503957752 YP_004412026.1 KEGG: gdj:Gdia_2446 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957753 YP_004412027.1 KEGG: osa:4332786 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957754 YP_004412028.1 COGs: COG1838 Tartrate dehydratase beta subunit/Fumarate hydratase class I C-terminal domain; InterPro IPR004647; KEGG: dly:Dehly_0361 hydro-lyase tartrate/fumarate subfamily subunit alpha; PFAM: Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain; PRIAM: Fumarate hydratase; SPTR: Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; TIGRFAM: Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain; IMG reference gene:2503957755; PFAM: Fumarase C-terminus; TIGRFAM: hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region YP_004412029.1 COGs: COG1951 Tartrate dehydratase alpha subunit/Fumarate hydratase class I N-terminal domain; InterPro IPR004646; KEGG: dds:Ddes_1528 hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit; PFAM: Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain; PRIAM: Fumarate hydratase; SPTR: Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha region; TIGRFAM: Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain; IMG reference gene:2503957756; PFAM: Fumarate hydratase (Fumerase); TIGRFAM: hydro-lyases, Fe-S type, tartrate/fumarate subfamily, alpha region YP_004412030.1 InterPro IPR006976; KEGG: hne:HNE_2912 hypothetical protein; PFAM: VanZ-like; SPTR: membrane protein; IMG reference gene:2503957757; PFAM: VanZ like family YP_004412031.1 COGs: COG1242 Fe-S oxidoreductase; InterPro IPR006638:IPR007197; KEGG: sta:STHERM_c02000 radical SAM protein; PFAM: Radical SAM; SMART: Elongator protein 3/MiaB/NifB; SPTR: Radical SAM protein; IMG reference gene:2503957758; PFAM: Radical SAM superfamily; TIGRFAM: radical SAM protein, TIGR01212 family YP_004412032.1 COGs: COG1752 esterase of the alpha-beta hydrolase superfamily; InterPro IPR002641; KEGG: ssm:Spirs_3807 patatin; PFAM: Patatin/Phospholipase A2-related; SPTR: membrane protein; IMG reference gene:2503957759; PFAM: Patatin-like phospholipase YP_004412033.1 COGs: COG0223 Methionyl-tRNA formyltransferase; HAMAP: Methionyl-tRNA formyltransferase; InterPro IPR005794:IPR002376:IPR005793; KEGG: ssm:Spirs_1655 methionyl-tRNA formyltransferase; PFAM: Formyl transferase, C-terminal; Formyl transferase, N-terminal; PRIAM: Methionyl-tRNA formyltransferase; SPTR: Methionyl-tRNA formyltransferase; TIGRFAM: Methionyl-tRNA formyltransferase; IMG reference gene:2503957760; PFAM: Formyl transferase; Formyl transferase, C-terminal domain; TIGRFAM: methionyl-tRNA formyltransferase YP_004412034.1 COGs: COG0242 N-formylmethionyl-tRNA deformylase; HAMAP: Formylmethionine deformylase; InterPro IPR000181; KEGG: ssm:Spirs_1654 peptide deformylase; PFAM: Formylmethionine deformylase; SPTR: Peptide deformylase; TIGRFAM: Formylmethionine deformylase; IMG reference gene:2503957761; PFAM: Polypeptide deformylase; TIGRFAM: peptide deformylase YP_004412035.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR002951:IPR011110:IPR000408; KEGG: aeh:Mlg_2687 regulator of chromosome condensation, RCC1; PFAM: Regulator of chromosome condensation, RCC1; Atrophin-like; Two component regulator propeller; SPTR: Regulator of chromosome condensation, RCC1; IMG reference gene:2503957762; PFAM: Regulator of chromosome condensation (RCC1) repeat YP_004412036.1 COGs: COG1198 Primosomal protein N' (replication factor Y) - superfamily II helicase; InterPro IPR014001:IPR001650:IPR005259:IPR011545; KEGG: ssm:Spirs_1653 primosomal protein N'; PFAM: DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Helicase, C-terminal; SMART: DEAD-like helicase, N-terminal; Helicase, C-terminal; SPTR: Primosomal protein N; TIGRFAM: Primosomal protein n; IMG reference gene:2503957764; PFAM: Helicase conserved C-terminal domain; DEAD/DEAH box helicase; TIGRFAM: primosomal protein N' YP_004412037.1 COGs: COG1573 Uracil-DNA glycosylase; InterPro IPR005273:IPR005122; KEGG: ssm:Spirs_1652 phage SPO1 DNA polymerase-related protein; PFAM: Uracil-DNA glycosylase-like; SPTR: uncharacterized protein; TIGRFAM: Phage SPO1 DNA polymerase-related protein; IMG reference gene:2503957765; PFAM: Uracil DNA glycosylase superfamily; TIGRFAM: uracil-DNA glycosylase, family 4 YP_004412038.1 COGs: COG0101 Pseudouridylate synthase; HAMAP: Pseudouridine synthase I, TruA; InterPro IPR001406:IPR020097; KEGG: cce:Ccel_0793 tRNA pseudouridine synthase A; PFAM: Pseudouridine synthase I, TruA, alpha/beta domain; PRIAM: tRNA-pseudouridine synthase I; SPTR: tRNA pseudouridine synthase A; TIGRFAM: Pseudouridine synthase I, TruA; IMG reference gene:2503957766; PFAM: tRNA pseudouridine synthase; TIGRFAM: pseudouridylate synthase I YP_004412039.1 COGs: COG0736 Phosphopantetheinyl transferase (holo-ACP synthase); HAMAP: Holo-[acyl carrier protein] synthase; InterPro IPR002582:IPR004568:IPR008278; KEGG: sta:STHERM_c18350 holo-(acyl-carrier-protein) synthase; PFAM: 4'-phosphopantetheinyl transferase; SPTR: Holo-(Acyl-carrier-protein) synthase; TIGRFAM: Holo-[acyl carrier protein] synthase; Phosphopantethiene-protein transferase; IMG reference gene:2503957767; PFAM: 4'-phosphopantetheinyl transferase superfamily; TIGRFAM: phosphopantethiene--protein transferase domain; holo-[acyl-carrier-protein] synthase YP_004412040.1 InterPro IPR012505; KEGG: ssm:Spirs_1648 YbbR family protein; PFAM: YbbR-like; SPTR: Membrane associated protein; IMG reference gene:2503957768; PFAM: YbbR-like protein YP_004412041.1 COGs: COG1624 conserved hypothetical protein; InterPro IPR014046:IPR003390; KEGG: ssm:Spirs_1647 protein of unknown function DUF147; PFAM: DNA integrity scanning protein, DisA, N-terminal; SPTR: uncharacterized protein; TIGRFAM: Conserved hypothetical protein CHP00159; IMG reference gene:2503957769; PFAM: DisA bacterial checkpoint controller nucleotide-binding; TIGRFAM: TIGR00159 family protein YP_004412042.1 COGs: COG1026 Zn-dependent peptidase insulinase-like; InterPro IPR011765:IPR007863:IPR013578; KEGG: ssm:Spirs_3660 peptidase M16C associated domain protein; PFAM: Peptidase M16, C-terminal; Peptidase M16, N-terminal; Peptidase M16C associated; SPTR: Presequence protease 1; IMG reference gene:2503957770; PFAM: Peptidase M16C associated; Peptidase M16 inactive domain; Insulinase (Peptidase M16) YP_004412043.1 COGs: COG0584 Glycerophosphoryl diester phosphodiesterase; InterPro IPR004129; KEGG: ssm:Spirs_3903 glycerophosphoryl diester phosphodiesterase; PFAM: Glycerophosphoryl diester phosphodiesterase; SPTR: Glycerophosphoryl diester phosphodiesterase, ; IMG reference gene:2503957771; PFAM: Glycerophosphoryl diester phosphodiesterase YP_004412044.1 KEGG: tde:TDE0730 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957772 YP_004412045.1 KEGG: yen:YE4032 hypothetical protein; SPTR: Cell envelope proteinase; IMG reference gene:2503957773 YP_004412046.1 COGs: COG2195 Di- and tripeptidase; InterPro IPR010161:IPR002933:IPR011650; KEGG: ssm:Spirs_3909 peptidase T; PFAM: Peptidase M20, dimerisation; Peptidase M20; PRIAM: Tripeptide aminopeptidase; SPTR: Peptidase T; TIGRFAM: Peptidase M20B, tripeptide aminopeptidase; IMG reference gene:2503957774; PFAM: Peptidase M20/M25/M40; Peptidase dimerisation domain; TIGRFAM: peptidase T YP_004412047.1 KEGG: ere:EUBREC_3205 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957775 YP_004412048.1 KEGG: ctt:CtCNB1_3098 TRAP dicarboxylate transporter, DctM subunit; SPTR: TRAP dicarboxylate transporter, DctM subunit; IMG reference gene:2503957776 YP_004412049.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR011110:IPR000408; KEGG: aeh:Mlg_2688 regulator of chromosome condensation, RCC1; PFAM: Regulator of chromosome condensation, RCC1; Two component regulator propeller; SPTR: uncharacterized protein; IMG reference gene:2503957777; PFAM: Regulator of chromosome condensation (RCC1) repeat YP_004412050.1 KEGG: isc:IscW_ISCW015120 GTP-binding protein, SPTR: GTP-binding protein, ; IMG reference gene:2503957778 YP_004412051.1 KEGG: hoh:Hoch_6421 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957779 YP_004412052.1 IMG reference gene:2503957780 YP_004412053.1 KEGG: ele:Elen_0127 DNA binding domain protein, excisionase; SPTR: DNA binding domain protein, excisionase; IMG reference gene:2503957781 YP_004412054.1 KEGG: mav:MAV_4833 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957782 YP_004412055.1 KEGG: mka:MK1527 formylmethanofuran dehydrogenase subunit B, selenocysteine containing; SPTR: ferrichrome transport ATP-binding protein FhuC; IMG reference gene:2503957783 YP_004412056.1 COGs: COG2344 AT-rich DNA-binding protein; HAMAP: Transcriptional repressor, redox-sensing, Rex; InterPro IPR003781:IPR009718:IPR022876; KEGG: ssm:Spirs_3692 CoA-binding domain protein; PFAM: CoA-binding; Rex DNA-binding, C-terminal; SMART: CoA-binding; SPTR: Redox-sensing transcriptional repressor rex; IMG reference gene:2503957784; PFAM: CoA binding domain; DNA-binding protein N-terminus YP_004412057.1 COGs: COG1897 Homoserine trans-succinylase; HAMAP: Homoserine O-succinyltransferase; InterPro IPR005697; KEGG: ttm:Tthe_0712 homoserine O-succinyltransferase; PFAM: Homoserine O-succinyltransferase; PRIAM: Homoserine O-succinyltransferase; SPTR: Homoserine O-succinyltransferase; TIGRFAM: Homoserine O-succinyltransferase; IMG reference gene:2503957785; PFAM: Homoserine O-succinyltransferase; TIGRFAM: homoserine O-succinyltransferase YP_004412058.1 COGs: COG2873 O-acetylhomoserine sulfhydrylase; InterPro IPR006235:IPR000277; KEGG: cpy:Cphy_0010 O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; PRIAM: Cysteine synthase; SPTR: uncharacterized protein; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; IMG reference gene:2503957786; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase YP_004412059.1 InterPro IPR005135; KEGG: ssm:Spirs_3694 endonuclease/exonuclease/phosphatase; PFAM: Endonuclease/exonuclease/phosphatase; SPTR: Endonuclease/exonuclease/phosphatase; IMG reference gene:2503957787; PFAM: Endonuclease/Exonuclease/phosphatase YP_004412060.1 KEGG: sta:STHERM_c14020 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957788 YP_004412061.1 COGs: COG0740 Protease subunit of ATP-dependent Clp protease; HAMAP: Peptidase S14, ClpP; InterPro IPR001907; KEGG: sta:STHERM_c05540 hypothetical protein; PFAM: Peptidase S14, ClpP; PRIAM: Endopeptidase Clp; SPTR: ATP-dependent Clp protease proteolytic subunit; IMG reference gene:2503957789; PFAM: Clp protease; TIGRFAM: ATP-dependent Clp protease, proteolytic subunit ClpP YP_004412062.1 KEGG: tde:TDE1234 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957790 YP_004412063.1 KEGG: tde:TDE1234 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957791 YP_004412064.1 KEGG: tde:TDE1234 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957792 YP_004412065.1 COGs: COG1285 membrane protein; InterPro IPR003416; KEGG: snb:SP670_2012 MgtC/SapB transporter; PFAM: MgtC/SapB transporter; SPTR: MgtC/SapB transporter; IMG reference gene:2503957793; PFAM: MgtC family YP_004412066.1 COGs: COG1159 GTPase; HAMAP: GTP-binding protein Era; InterPro IPR005225:IPR005662:IPR002917:IPR004044; KEGG: ssm:Spirs_3698 GTP-binding protein Era; PFAM: GTP-binding protein, HSR1-related; K Homology, type 2; SPTR: GTP-binding protein; TIGRFAM: GTP-binding protein Era; Small GTP-binding protein; IMG reference gene:2503957794; PFAM: KH domain; GTPase of unknown function; TIGRFAM: GTP-binding protein Era; small GTP-binding protein domain YP_004412067.1 COGs: COG1940 Transcriptional regulator/sugar kinase; InterPro IPR000600; KEGG: cwo:Cwoe_1260 ROK family protein; PFAM: ROK; SPTR: ROK family protein; IMG reference gene:2503957795; PFAM: ROK family YP_004412068.1 InterPro IPR004300; KEGG: pst:PSPTO_4203 polysaccharide deacetylase; PFAM: Glycoside hydrolase, family 57, N-terminal; SPTR: Polysaccharide deacetylase; IMG reference gene:2503957796; PFAM: Glycosyl hydrolase 57 YP_004412069.1 COGs: COG2159 metal-dependent hydrolase of the TIM-barrel fold; InterPro IPR006992; KEGG: tle:Tlet_1114 amidohydrolase 2; PFAM: Amidohydrolase 2; SPTR: Amidohydrolase 2; IMG reference gene:2503957797; PFAM: Amidohydrolase YP_004412070.1 COGs: COG0395 ABC-type sugar transport system permease component; InterPro IPR000515; KEGG: atu:Atu4652 ABC transporter, membrane spanning protein (sugar); PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: ABC transporter, membrane spanning protein (Sugar); IMG reference gene:2503957798; PFAM: Binding-protein-dependent transport system inner membrane component YP_004412071.1 COGs: COG1175 ABC-type sugar transport systems permease components; InterPro IPR000515; KEGG: atu:Atu4653 ABC transporter, membrane spanning protein (sugar); PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: ABC transporter, membrane spanning protein (Sugar); IMG reference gene:2503957799; PFAM: Binding-protein-dependent transport system inner membrane component YP_004412072.1 COGs: COG1653 ABC-type sugar transport system periplasmic component; InterPro IPR006059; KEGG: tle:Tlet_1117 extracellular solute-binding protein; PFAM: Bacterial extracellular solute-binding, family 1; SPTR: Extracellular solute-binding protein family 1; IMG reference gene:2503957800; PFAM: Bacterial extracellular solute-binding protein YP_004412073.1 COGs: COG1109 Phosphomannomutase; InterPro IPR005844:IPR005845; KEGG: chy:CHY_2012 phosphoglucosamine mutase; PFAM: Alpha-D-phosphohexomutase, alpha/beta/alpha domain I; Alpha-D-phosphohexomutase, alpha/beta/alpha domain II; PRIAM: Phosphoglucosamine mutase; SPTR: Phosphoglucosamine mutase; IMG reference gene:2503957801; PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I YP_004412074.1 COGs: COG1384 Lysyl-tRNA synthetase (class I); HAMAP: Lysyl-tRNA synthetase, class I, archaeal-type; InterPro IPR002904:IPR020754:IPR020756; KEGG: ssm:Spirs_3699 lysyl-tRNA synthetase; PFAM: Lysyl-tRNA synthetase, class Ic; PRIAM: Lysine--tRNA ligase; SPTR: uncharacterized protein; TIGRFAM: Lysyl-tRNA synthetase, class I; IMG reference gene:2503957802; PFAM: tRNA synthetases class I (K); TIGRFAM: lysyl-tRNA synthetase, archaeal and spirochete YP_004412075.1 COGs: COG0797 Lipoprotein; InterPro IPR012997:IPR009009; KEGG: ssm:Spirs_0552 rare lipoprotein A; PFAM: Barwin-related endoglucanase; SPTR: RAre lipoprotein A rlpa; TIGRFAM: Rare lipoprotein A, bacterial; IMG reference gene:2503957803; PFAM: Rare lipoprotein A (RlpA)-like double-psi beta-barrel; TIGRFAM: rare lipoprotein A YP_004412076.1 KEGG: lbf:LBF_1543 cytoplasmic membrane protein, ImpL63; SPTR: Macrolide export ATP-binding/permease MacB; IMG reference gene:2503957804 YP_004412077.1 COGs: COG0525 Valyl-tRNA synthetase; HAMAP: Valyl-tRNA synthetase; InterPro IPR002303:IPR002300:IPR013155:IPR019499; KEGG: ssm:Spirs_2147 valyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class Ia; Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding; Valyl-tRNA synthetase, class Ia, tRNA-binding arm; PRIAM: Valine--tRNA ligase; SPTR: Valyl-tRNA synthetase; TIGRFAM: Valyl-tRNA synthetase; IMG reference gene:2503957806; PFAM: tRNA synthetases class I (I, L, M and V); Anticodon-binding domain; Valyl tRNA synthetase tRNA binding arm; TIGRFAM: valyl-tRNA synthetase YP_004412078.1 InterPro IPR011701; KEGG: cbt:CLH_2235 permease of the major facilitator superfamily; PFAM: Major facilitator superfamily MFS-1; SPTR: Possible MDR-type permease; IMG reference gene:2503957807; PFAM: Major Facilitator Superfamily YP_004412079.1 COGs: COG4587 ABC-type uncharacterized transport system permease component; InterPro IPR010390; KEGG: fnu:FN0879 ABC transporter integral membrane protein; PFAM: Protein of unknown function DUF990; SPTR: Membrane protein; IMG reference gene:2503957808; PFAM: Protein of unknown function (DUF990) YP_004412080.1 COGs: COG4586 ABC-type uncharacterized transport system ATPase component; InterPro IPR003593:IPR003439; KEGG: fnu:FN0880 ABC transporter ATP-binding protein; PFAM: ABC transporter-like; SMART: ATPase, AAA+ type, core; SPTR: Daunorubicin resistance ATP-binding protein drrA; IMG reference gene:2503957809; PFAM: ABC transporter YP_004412081.1 COGs: COG3694 ABC-type uncharacterized transport system permease component; InterPro IPR010390; KEGG: fnu:FN0881 ABC transporter integral membrane protein; PFAM: Protein of unknown function DUF990; SPTR: ABC transporter permease; IMG reference gene:2503957810; PFAM: Protein of unknown function (DUF990) YP_004412082.1 COGs: COG2818 3-methyladenine DNA glycosylase; InterPro IPR005019; KEGG: vpr:Vpar_1788 methyladenine glycosylase; PFAM: Methyladenine glycosylase; PRIAM: DNA-3-methyladenine glycosylase I; SPTR: DNA-3-methyladenine glycosylase I; IMG reference gene:2503957811; PFAM: Methyladenine glycosylase; TIGRFAM: DNA-3-methyladenine glycosylase I YP_004412083.1 COGs: COG1112 Superfamily I DNA and RNA helicase and helicase subunits; KEGG: ere:EUBREC_0650 DNA helicase; SPTR: DNA helicase; IMG reference gene:2503957812; PFAM: UvrD/REP helicase; Protein of unknown function (DUF2726) YP_004412084.1 COGs: COG3177 conserved hypothetical protein; InterPro IPR003812; KEGG: clo:HMPREF0868_0124 Fic family protein; PFAM: Filamentation induced by cAMP/death on curing-related; SPTR: Fic family protein; IMG reference gene:2503957813; PFAM: Fic/DOC family YP_004412085.1 IMG reference gene:2503957814 YP_004412086.1 COGs: COG2120 conserved hypothetical protein LmbE homologs; InterPro IPR003737; KEGG: sus:Acid_1929 LmbE family protein; PFAM: N-acetylglucosaminyl phosphatidylinositol deacetylase; SPTR: LmbE family protein; IMG reference gene:2503957815; PFAM: GlcNAc-PI de-N-acetylase YP_004412087.1 COGs: COG1282 NAD/NADP transhydrogenase beta subunit; InterPro IPR004003; KEGG: lic:LIC10290 H+-translocating transhydrogenase subunit beta; PFAM: NAD(P) transhydrogenase, beta subunit; PRIAM: NAD(P)(+) transhydrogenase (AB-specific); SPTR: NAD(P) transhydrogenase subunit beta; IMG reference gene:2503957816; PFAM: NAD(P) transhydrogenase beta subunit YP_004412088.1 COGs: COG3288 NAD/NADP transhydrogenase alpha subunit; KEGG: lbf:LBF_0175 NAD(P)(+) transhydrogenase-like protein; SPTR: Proton-translocating transhydrogenase subunit alpha 2; IMG reference gene:2503957817 YP_004412089.1 COGs: COG3288 NAD/NADP transhydrogenase alpha subunit; InterPro IPR007886:IPR007698; KEGG: abo:ABO_1329 pyridine nucleotide transhydrogenase A subunit; PFAM: Alanine dehydrogenase/PNT, C-terminal; Alanine dehydrogenase/PNT, N-terminal; PRIAM: NAD(P)(+) transhydrogenase (AB-specific); SPTR: Nicotinamide nucleotide transhydrogenase, subunit alpha; IMG reference gene:2503957818; PFAM: Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase/PNT, N-terminal domain; TIGRFAM: NAD(P) transhydrogenase, alpha subunit YP_004412090.1 COGs: COG0277 FAD/FMN-containing dehydrogenase; InterPro IPR006094:IPR004113; KEGG: amt:Amet_3747 FAD linked oxidase domain-containing protein; PFAM: FAD-linked oxidase, C-terminal; FAD linked oxidase, N-terminal; PRIAM: D-lactate dehydrogenase (cytochrome); SPTR: FAD linked oxidase domain protein; IMG reference gene:2503957819; PFAM: FAD binding domain; FAD linked oxidases, C-terminal domain; TIGRFAM: glycolate oxidase, subunit GlcD YP_004412091.1 COGs: COG2025 Electron transfer flavoprotein alpha subunit; InterPro IPR014730:IPR014731; KEGG: amt:Amet_3748 electron transfer flavoprotein, alpha subunit-like protein; PFAM: Electron transfer flavoprotein, alpha subunit, C-terminal; Electron transfer flavoprotein, alpha/beta-subunit, N-terminal; SMART: Electron transfer flavoprotein, alpha/beta-subunit, N-terminal; SPTR: Electron transfer flavoprotein, alpha subunit-like protein; IMG reference gene:2503957820; PFAM: Electron transfer flavoprotein domain; Electron transfer flavoprotein FAD-binding domain YP_004412092.1 COGs: COG2086 Electron transfer flavoprotein beta subunit; InterPro IPR014730; KEGG: amt:Amet_3749 electron transfer flavoprotein, alpha/beta-subunit-like protein; PFAM: Electron transfer flavoprotein, alpha/beta-subunit, N-terminal; SMART: Electron transfer flavoprotein, alpha/beta-subunit, N-terminal; SPTR: Electron transfer flavoprotein, alpha/beta-subunit-like protein; IMG reference gene:2503957821; PFAM: Electron transfer flavoprotein domain YP_004412093.1 COGs: COG1080 Phosphoenolpyruvate-protein kinase (PTS system EI component); InterPro IPR006318:IPR008731:IPR008279:IPR000121; KEGG: csc:Csac_2437 phosphoenolpyruvate-protein phosphotransferase; PFAM: PEP-utilising enzyme; Phosphotransferase system, PEP-utilising enzyme, N-terminal; PEP-utilising enzyme, mobile domain; PRIAM: Phosphoenolpyruvate--protein phosphotransferase; SPTR: Phosphoenolpyruvate--protein phosphotransferase; TIGRFAM: Phosphoenolpyruvate-protein phosphotransferase; IMG reference gene:2503957822; PFAM: PEP-utilising enzyme, mobile domain; PEP-utilising enzyme, TIM barrel domain; PEP-utilising enzyme, N-terminal; TIGRFAM: phosphoenolpyruvate-protein phosphotransferase YP_004412094.1 COGs: COG1925 Phosphotransferase system HPr-related protein; InterPro IPR005698; KEGG: eel:EUBELI_20516 phosphocarrier protein HPr; PFAM: Phosphotransferase system, phosphocarrier HPr protein; SPTR: uncharacterized protein; TIGRFAM: Phosphotransferase system, phosphocarrier HPr protein; IMG reference gene:2503957823; PFAM: PTS HPr component phosphorylation site; TIGRFAM: Phosphotransferase System HPr (HPr) Family YP_004412095.1 COGs: COG1015 Phosphopentomutase; InterPro IPR006124; KEGG: sfv:SFV_3385 mutase; PFAM: Metalloenzyme; SPTR: Phosphopentomutase; IMG reference gene:2503957824; PFAM: Metalloenzyme superfamily YP_004412096.1 COGs: COG3457 amino acid racemase; InterPro IPR001608; KEGG: thx:Thet_0218 alanine racemase domain-containing protein; PFAM: Alanine racemase, N-terminal; SPTR: uncharacterized protein; IMG reference gene:2503957825; PFAM: Alanine racemase, N-terminal domain YP_004412097.1 KEGG: csh:Closa_2021 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957826; PFAM: Aminotransferase class-V YP_004412098.1 COGs: COG1735 metal-dependent hydrolase with the TIM-barrel fold; InterPro IPR001559; KEGG: str:Sterm_0361 aryldialkylphosphatase; PFAM: Aryldialkylphosphatase; SPTR: Phosphotriesterase-like protein; IMG reference gene:2503957827; PFAM: Phosphotriesterase YP_004412099.1 KEGG: csh:Closa_2023 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957828; PFAM: Amidase YP_004412100.1 InterPro IPR019733; KEGG: ttm:Tthe_1693 protein of unknown function, YhfT; PFAM: Uncharacterised protein family YhfT; SPTR: uncharacterized protein; IMG reference gene:2503957829; PFAM: Protein of unknown function YP_004412101.1 KEGG: xbo:XBJ1_0132 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957830; PFAM: Protein of unknown function DUF2620 YP_004412102.1 InterPro IPR011608; KEGG: sth:STH556 transcriptional antiterminator; PFAM: PRD; SPTR: Predicted protein; IMG reference gene:2503957831; PFAM: PRD domain YP_004412103.1 KEGG: thx:Thet_0211 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957832 YP_004412104.1 COGs: COG1979 Uncharacterized oxidoreductase Fe-dependent alcohol dehydrogenase; InterPro IPR001670; KEGG: apa:APP7_1949 probable NADH-dependent butanol dehydrogenase 1; PFAM: Alcohol dehydrogenase, iron-type; PRIAM: Alcohol dehydrogenase; SPTR: Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase; IMG reference gene:2503957833; PFAM: Iron-containing alcohol dehydrogenase YP_004412105.1 COGs: COG1132 ABC-type multidrug transport system ATPase and permease components; InterPro IPR003593:IPR001140:IPR003439; KEGG: ssm:Spirs_3268 ABC transporter related protein; PFAM: ABC transporter-like; ABC transporter, transmembrane domain; PRIAM: Xenobiotic-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC-type multidrug transport system, ATPase and permease components; IMG reference gene:2503957834; PFAM: ABC transporter transmembrane region; ABC transporter YP_004412106.1 COGs: COG1132 ABC-type multidrug transport system ATPase and permease components; InterPro IPR003593:IPR001140:IPR003439; KEGG: ssm:Spirs_3269 ABC transporter related protein; PFAM: ABC transporter-like; ABC transporter, transmembrane domain; PRIAM: Xenobiotic-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: uncharacterized protein; IMG reference gene:2503957835; PFAM: ABC transporter transmembrane region; ABC transporter YP_004412107.1 InterPro IPR000835; KEGG: ssm:Spirs_3270 transcriptional regulator, MarR family; PFAM: HTH transcriptional regulator, MarR; SMART: HTH transcriptional regulator, MarR; SPTR: Transcriptional regulator, MarR family; IMG reference gene:2503957836; PFAM: MarR family YP_004412108.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR013378:IPR011110:IPR000408; KEGG: aeh:Mlg_2687 regulator of chromosome condensation, RCC1; PFAM: Regulator of chromosome condensation, RCC1; Listeria/Bacterioides repeat; Two component regulator propeller; SPTR: uncharacterized protein; IMG reference gene:2503957837; PFAM: Listeria-Bacteroides repeat domain (List_Bact_rpt); Regulator of chromosome condensation (RCC1) repeat YP_004412109.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR013378:IPR000408; KEGG: aeh:Mlg_2687 regulator of chromosome condensation, RCC1; PFAM: Regulator of chromosome condensation, RCC1; Listeria/Bacterioides repeat; SPTR: uncharacterized protein; IMG reference gene:2503957838; PFAM: Listeria-Bacteroides repeat domain (List_Bact_rpt); Regulator of chromosome condensation (RCC1) repeat YP_004412110.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR013378:IPR011110:IPR000408; KEGG: aeh:Mlg_2687 regulator of chromosome condensation, RCC1; PFAM: Listeria/Bacterioides repeat; Two component regulator propeller; Regulator of chromosome condensation, RCC1; SPTR: uncharacterized protein; TIGRFAM: Listeria/Bacterioides repeat; IMG reference gene:2503957839; PFAM: Listeria-Bacteroides repeat domain (List_Bact_rpt); Regulator of chromosome condensation (RCC1) repeat; TIGRFAM: Listeria/Bacterioides repeat YP_004412111.1 InterPro IPR014922; KEGG: gur:Gura_3522 hypothetical protein; PFAM: Protein of unknown function DUF1801; SPTR: uncharacterized protein; IMG reference gene:2503957840; PFAM: Domain of unknown function (DU1801) YP_004412112.1 COGs: COG1114 Branched-chain amino acid permease; InterPro IPR004685; KEGG: efa:EF0243 branched-chain amino acid transport system II carrier protein; PFAM: Branched-chain amino acid transport system II carrier protein; SPTR: Branched-chain amino acid transport system II carrier protein; TIGRFAM: Branched-chain amino acid transport system II carrier protein; IMG reference gene:2503957841; PFAM: Branched-chain amino acid transport protein; TIGRFAM: branched-chain amino acid uptake carrier YP_004412113.1 COGs: COG0730 permease; InterPro IPR002781; KEGG: cbt:CLH_3273 transporter; PFAM: Protein of unknown function DUF81; SPTR: Transporter; IMG reference gene:2503957842; PFAM: Sulfite exporter TauE/SafE YP_004412114.1 InterPro IPR006104:IPR006103; KEGG: cpy:Cphy_3081 glycoside hydrolase; PFAM: Glycoside hydrolase, family 2, carbohydrate-binding; Glycoside hydrolase, family 2, TIM barrel; SPTR: Glycoside hydrolase 2 sugar binding; IMG reference gene:2503957843 YP_004412115.1 InterPro IPR015305; KEGG: bld:BLi01374 YesU; PFAM: Protein of unknown function DUF1961; SPTR: YesU; IMG reference gene:2503957844; PFAM: Domain of unknown function (DUF1961) YP_004412116.1 KEGG: cpy:Cphy_3080 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957845 YP_004412117.1 COGs: COG1653 ABC-type sugar transport system periplasmic component; InterPro IPR006059; KEGG: cpy:Cphy_0341 extracellular solute-binding protein; PFAM: Bacterial extracellular solute-binding, family 1; SPTR: uncharacterized protein; IMG reference gene:2503957846; PFAM: Bacterial extracellular solute-binding protein YP_004412118.1 COGs: COG0395 ABC-type sugar transport system permease component; InterPro IPR000515; KEGG: cpy:Cphy_0340 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: uncharacterized protein; IMG reference gene:2503957847; PFAM: Binding-protein-dependent transport system inner membrane component YP_004412119.1 COGs: COG4209 ABC-type polysaccharide transport system permease component; InterPro IPR000515; KEGG: cob:COB47_1870 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: uncharacterized protein; IMG reference gene:2503957848; PFAM: Binding-protein-dependent transport system inner membrane component YP_004412120.1 COGs: COG1132 ABC-type multidrug transport system ATPase and permease components; InterPro IPR003593:IPR001140:IPR003439; KEGG: pjd:Pjdr2_0901 ABC transporter related; PFAM: ABC transporter-like; ABC transporter, transmembrane domain; PRIAM: Xenobiotic-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: uncharacterized protein; IMG reference gene:2503957849; PFAM: ABC transporter transmembrane region; ABC transporter YP_004412121.1 COGs: COG1132 ABC-type multidrug transport system ATPase and permease components; InterPro IPR003593:IPR001140:IPR003439; KEGG: pjd:Pjdr2_0902 ABC transporter related; PFAM: ABC transporter-like; ABC transporter, transmembrane domain; PRIAM: Xenobiotic-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter ATP-binding protein; IMG reference gene:2503957850; PFAM: ABC transporter transmembrane region; ABC transporter YP_004412122.1 COGs: COG0637 phosphatase/phosphohexomutase; InterPro IPR010972:IPR010976:IPR006402:IPR005834; KEGG: csh:Closa_0870 beta-phosphoglucomutase; PFAM: Haloacid dehalogenase-like hydrolase; PRIAM: Beta-phosphoglucomutase; SPTR: Beta-phosphoglucomutase; TIGRFAM: Beta-phosphoglucomutase; Beta-phosphoglucomutase hydrolase; HAD-superfamily hydrolase, subfamily IA, variant 3; IMG reference gene:2503957851; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: beta-phosphoglucomutase; beta-phosphoglucomutase hydrolase; haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED YP_004412123.1 COGs: COG1554 Trehalose and maltose hydrolase (possible phosphorylase); InterPro IPR005196:IPR005195:IPR005194; KEGG: gym:GYMC10_0477 glycoside hydrolase 65 central catalytic; PFAM: Glycoside hydrolase, family 65, central catalytic; Glycoside hydrolase, family 65, N-terminal; Glycoside hydrolase, family 65, C-terminal; PRIAM: Kojibiose phosphorylase; SPTR: uncharacterized protein; IMG reference gene:2503957852; PFAM: Glycosyl hydrolase 65, C-terminal domain; Glycosyl hydrolase 65 central catalytic domain; Glycosyl hydrolase 65, N-terminal domain YP_004412124.1 COGs: COG0395 ABC-type sugar transport system permease component; InterPro IPR000515; KEGG: gym:GYMC10_0424 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Binding-protein-dependent transport systems inner membrane component; IMG reference gene:2503957853; PFAM: Binding-protein-dependent transport system inner membrane component YP_004412125.1 COGs: COG1175 ABC-type sugar transport systems permease components; InterPro IPR000515; KEGG: gym:GYMC10_0423 binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Binding-protein-dependent transport systems inner membrane component; IMG reference gene:2503957854; PFAM: Binding-protein-dependent transport system inner membrane component YP_004412126.1 COGs: COG1653 ABC-type sugar transport system periplasmic component; InterPro IPR006059; KEGG: gym:GYMC10_0422 extracellular solute-binding protein family 1; PFAM: Bacterial extracellular solute-binding, family 1; SPTR: Extracellular solute-binding protein family 1; IMG reference gene:2503957855; PFAM: Bacterial extracellular solute-binding protein YP_004412127.1 COGs: COG1609 Transcriptional regulators; InterPro IPR000843:IPR001761; KEGG: gym:GYMC10_0421 transcriptional regulator, LacI family; PFAM: HTH transcriptional regulator, LacI; Periplasmic binding protein/LacI transcriptional regulator; SMART: HTH transcriptional regulator, LacI; SPTR: Transcriptional regulator, LacI family; IMG reference gene:2503957856; PFAM: Bacterial regulatory proteins, lacI family; family YP_004412128.1 COGs: COG3830 ACT domain-containing protein; HAMAP: Uncharacterised protein family UPF0237, ACT domain-containing; InterPro IPR022986:IPR002912; KEGG: bde:BDP_1787 ACT domain-containing protein; PFAM: Amino acid-binding ACT; SPTR: uncharacterized protein; IMG reference gene:2503957857; PFAM: ACT domain YP_004412129.1 COGs: COG2848 conserved hypothetical protein; HAMAP: Uncharacterised protein family UPF0210; InterPro IPR007841; KEGG: cpy:Cphy_2797 hypothetical protein; PFAM: Uncharacterised protein family UPF0210; SPTR: UPF0210 protein Cphy_2797; IMG reference gene:2503957858; PFAM: Uncharacterized ACR (DUF711) YP_004412130.1 COGs: COG5015 conserved hypothetical protein; InterPro IPR011576; KEGG: bpb:bpr_I1023 pyridoxamine 5'-phosphate oxidase; PFAM: Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain; SPTR: Pyridoxamine 5'-phosphate oxidase; IMG reference gene:2503957860; PFAM: Pyridoxamine 5'-phosphate oxidase YP_004412131.1 KEGG: bfr:BF3847 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957861 YP_004412132.1 COGs: COG0534 Na+-driven multidrug efflux pump; InterPro IPR002528; KEGG: cbk:CLL_A1589 Na+-driven multidrug efflux pump; PFAM: Multi antimicrobial extrusion protein; SPTR: Mate efflux family protein; TIGRFAM: Multi antimicrobial extrusion protein; IMG reference gene:2503957862; PFAM: MatE; TIGRFAM: efflux protein, MATE family YP_004412133.1 COGs: COG1180 Pyruvate-formate lyase-activating enzyme; InterPro IPR012838:IPR007197; KEGG: efa:EF1612 pyruvate formate-lyase activating enzyme; PFAM: Radical SAM; PRIAM: [Formate-C-acetyltransferase]-activating enzyme; SPTR: Pyruvate formate-lyase 1-activating enzyme; TIGRFAM: Pyruvate formate-lyase activating; IMG reference gene:2503957863; PFAM: Radical SAM superfamily; TIGRFAM: pyruvate formate-lyase 1-activating enzyme YP_004412134.1 COGs: COG1882 Pyruvate-formate lyase; InterPro IPR005949:IPR004184:IPR001150; KEGG: efa:EF1613 formate acetyltransferase; PFAM: Pyruvate formate-lyase, PFL; Formate C-acetyltransferase glycine radical; PRIAM: Formate C-acetyltransferase; SPTR: Formate acetyltransferase; TIGRFAM: Formate acetyltransferase; IMG reference gene:2503957864; PFAM: Glycine radical; Pyruvate formate lyase; TIGRFAM: formate acetyltransferase 1 YP_004412135.1 COGs: COG2502 Asparagine synthetase A; HAMAP: Aspartate--ammonia ligase; InterPro IPR004618; KEGG: pdi:BDI_3717 asparagine synthetase AsnA; PFAM: Aspartate--ammonia ligase; PRIAM: Aspartate--ammonia ligase; SPTR: Aspartate--ammonia ligase; TIGRFAM: Aspartate--ammonia ligase; IMG reference gene:2503957865; PFAM: Aspartate-ammonia ligase; TIGRFAM: aspartate--ammonia ligase, AsnA-type YP_004412136.1 COGs: COG2081 flavoprotein; InterPro IPR004792; KEGG: mhu:Mhun_1926 HI0933-like protein; PFAM: Conserved hypothetical protein CHP00275, flavoprotein HI0933-like; SPTR: HI0933 family protein; TIGRFAM: Conserved hypothetical protein CHP00275, flavoprotein HI0933-like; IMG reference gene:2503957866; PFAM: HI0933-like protein; TIGRFAM: flavoprotein, HI0933 family YP_004412137.1 COGs: COG0431 flavoprotein; InterPro IPR005025; KEGG: cpy:Cphy_1114 NADPH-dependent FMN reductase; PFAM: NADPH-dependent FMN reductase; SPTR: NADPH-dependent FMN reductase; IMG reference gene:2503957867; PFAM: NADPH-dependent FMN reductase YP_004412138.1 InterPro IPR011493; KEGG: hwa:HQ1081A halomucin; SPTR: Halomucin; IMG reference gene:2503957868 YP_004412139.1 COGs: COG2055 Malate/L-lactate dehydrogenase; InterPro IPR003767; KEGG: kol:Kole_0486 malate/L-lactate dehydrogenase; PFAM: Malate/L-lactate dehydrogenase; PRIAM: Malate dehydrogenase; SPTR: Malate/L-lactate dehydrogenase; IMG reference gene:2503957869; PFAM: Malate/L-lactate dehydrogenase YP_004412140.1 COGs: COG1349 Transcriptional regulators of sugar metabolism; InterPro IPR001034:IPR014036; KEGG: pca:Pcar_0940 DeoR-type transcriptional regulator; PFAM: HTH transcriptional regulator, DeoR; HTH transcriptional regulator, DeoR N-terminal; SMART: HTH transcriptional regulator, DeoR N-terminal; SPTR: Transcriptional regulator, DeoR family; IMG reference gene:2503957870; PFAM: Bacterial regulatory proteins, deoR family; DeoR-like helix-turn-helix domain YP_004412141.1 COGs: COG0554 Glycerol kinase; HAMAP: Glycerol kinase; InterPro IPR005999:IPR018484:IPR018485; KEGG: ssm:Spirs_1645 glycerol kinase; PFAM: Carbohydrate kinase, FGGY, N-terminal; Carbohydrate kinase, FGGY, C-terminal; PRIAM: Glycerol kinase; SPTR: Glycerol kinase; TIGRFAM: Glycerol kinase; IMG reference gene:2503957871; PFAM: FGGY family of carbohydrate kinases, N-terminal domain; FGGY family of carbohydrate kinases, C-terminal domain; TIGRFAM: glycerol kinase YP_004412142.1 COGs: COG3007 Uncharacterized paraquat-inducible protein B; HAMAP: Uncharacterised protein family, TER reductase; InterPro IPR010758; KEGG: sta:STHERM_c16300 trans-2-enoyl-CoA reductase; PFAM: Uncharacterised protein family, TER reductase; PRIAM: Trans-2-enoyl-CoA reductase (NAD(+)); SPTR: Trans-2-enoyl-CoA reductase; IMG reference gene:2503957872; PFAM: Trans-2-enoyl-CoA reductase catalytic region; NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Enoyl reductase FAD binding domain YP_004412143.1 COGs: COG0764 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase; InterPro IPR013114; KEGG: sta:STHERM_c08550 beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; PFAM: Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase, FabA/FabZ; SPTR: Beta-hydroxyacyl-(Acyl-carrier-protein) dehydratase FabZ; IMG reference gene:2503957873; PFAM: FabA-like domain YP_004412144.1 COGs: COG0304 3-oxoacyl-(acyl-carrier-protein) synthase; InterPro IPR017568:IPR014030:IPR014031:IPR020841; KEGG: ssm:Spirs_2300 3-oxoacyl-(acyl-carrier-protein) synthase 2; PFAM: Beta-ketoacyl synthase, N-terminal; Beta-ketoacyl synthase, C-terminal; PRIAM: Beta-ketoacyl-acyl-carrier-protein synthase II; SMART: Polyketide synthase, beta-ketoacyl synthase domain; SPTR: 3-oxoacyl-[acyl-carrier-protein] synthase 2; TIGRFAM: 3-oxoacyl-[acyl-carrier-protein] synthase 2; IMG reference gene:2503957874; PFAM: Beta-ketoacyl synthase, N-terminal domain; Beta-ketoacyl synthase, C-terminal domain; TIGRFAM: beta-ketoacyl-acyl-carrier-protein synthase II YP_004412145.1 COGs: COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase); InterPro IPR011284:IPR002198:IPR020842; KEGG: sta:STHERM_c21540 3-oxoacyl-[acyl-carrier-protein] reductase; PFAM: Short-chain dehydrogenase/reductase SDR; PRIAM: 3-oxoacyl-[acyl-carrier-protein] reductase; SMART: Polyketide synthase/Fatty acid synthase, KR; SPTR: 3-oxoacyl-[acyl-carrier-protein] reductase; TIGRFAM: 3-oxoacyl-(acyl-carrier-protein) reductase; IMG reference gene:2503957875; PFAM: short chain dehydrogenase; TIGRFAM: 3-oxoacyl-(acyl-carrier-protein) reductase YP_004412146.1 COGs: COG0331 (acyl-carrier-protein) S-malonyltransferase; InterPro IPR014043:IPR020801; KEGG: sta:STHERM_c21550 hypothetical protein; PFAM: Acyl transferase; PRIAM: [Acyl-carrier-protein] S-malonyltransferase; SMART: Polyketide synthase, acyl transferase domain; SPTR: uncharacterized protein; IMG reference gene:2503957876; PFAM: Acyl transferase domain; TIGRFAM: malonyl CoA-acyl carrier protein transacylase YP_004412147.1 COGs: COG0511 Biotin carboxyl carrier protein; InterPro IPR001249:IPR000089; KEGG: bts:Btus_0728 acetyl-CoA carboxylase, biotin carboxyl carrier protein; PFAM: Biotin/lipoyl attachment; SPTR: Acetyl-CoA carboxylase, biotin carboxyl carrier protein; TIGRFAM: Acetyl-CoA biotin carboxyl carrier; IMG reference gene:2503957877; PFAM: Biotin-requiring enzyme; TIGRFAM: acetyl-CoA carboxylase, biotin carboxyl carrier protein YP_004412148.1 COGs: COG4770 Acetyl/propionyl-CoA carboxylase alpha subunit; InterPro IPR005481:IPR005479:IPR005482; KEGG: sta:STHERM_c08570 pyruvate carboxylase subunit A; PFAM: Carbamoyl-phosphate synthetase, large subunit, ATP-binding; Carbamoyl-phosphate synthase, large subunit, N-terminal; Biotin carboxylase, C-terminal; PRIAM: Biotin carboxylase; SMART: Biotin carboxylase, C-terminal; SPTR: Pyruvate carboxylase subunit A; IMG reference gene:2503957878; PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; Biotin carboxylase C-terminal domain; Carbamoyl-phosphate synthase L chain, N-terminal domain YP_004412149.1 COGs: COG0777 Acetyl-CoA carboxylase beta subunit; HAMAP: Acetyl-CoA carboxylase carboxyl transferase, beta subunit; InterPro IPR000438:IPR000022; KEGG: ssm:Spirs_2294 acetyl-CoA carboxylase, carboxyl transferase, beta subunit; PFAM: Carboxyl transferase; PRIAM: Acetyl-CoA carboxylase; SPTR: Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; IMG reference gene:2503957879; PFAM: Carboxyl transferase domain; TIGRFAM: acetyl-CoA carboxylase, carboxyl transferase, beta subunit YP_004412150.1 COGs: COG0825 Acetyl-CoA carboxylase alpha subunit; HAMAP: Acetyl-CoA carboxylase, alpha subunit; InterPro IPR001095; KEGG: tde:TDE0589 acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; PFAM: Acetyl-CoA carboxylase, alpha subunit; PRIAM: Acetyl-CoA carboxylase; SPTR: Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; TIGRFAM: Acetyl-CoA carboxylase, alpha subunit; IMG reference gene:2503957880; PFAM: Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; TIGRFAM: acetyl-CoA carboxylase, carboxyl transferase, alpha subunit YP_004412151.1 COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR000873; KEGG: pdi:BDI_2255 acetyl-coenzyme A synthetase; PFAM: AMP-dependent synthetase/ligase; PRIAM: Butyrate--CoA ligase; SPTR: uncharacterized protein; IMG reference gene:2503957881; PFAM: AMP-binding enzyme YP_004412152.1 COGs: COG5496 thioesterase; KEGG: cob:COB47_1987 thioesterase superfamily protein; SPTR: uncharacterized protein; IMG reference gene:2503957882 YP_004412153.1 COGs: COG2814 Arabinose efflux permease; InterPro IPR011701; KEGG: cbe:Cbei_0707 major facilitator transporter; PFAM: Major facilitator superfamily MFS-1; SPTR: Major facilitator superfamily MFS_1; IMG reference gene:2503957883; PFAM: Major Facilitator Superfamily YP_004412154.1 COGs: COG2077 Peroxiredoxin; HAMAP: thiol peroxidase Tpx; InterPro IPR002065:IPR013740; KEGG: cbt:CLH_2671 thiol peroxidase; PFAM: Redoxin; SPTR: thiol peroxidase; IMG reference gene:2503957884; PFAM: Redoxin YP_004412155.1 InterPro IPR013096; KEGG: sus:Acid_7125 cupin 2 domain-containing protein; PFAM: Cupin 2, conserved barrel; SPTR: uncharacterized protein; IMG reference gene:2503957885; PFAM: Cupin domain YP_004412156.1 COGs: COG1053 Succinate dehydrogenase/fumarate reductase flavoprotein subunit; InterPro IPR003953; KEGG: ske:Sked_06460 succinate dehydrogenase/fumarate reductase flavoprotein subunit; PFAM: Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal; SPTR: uncharacterized protein; IMG reference gene:2503957886; PFAM: FAD binding domain YP_004412157.1 COGs: COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase); InterPro IPR002198:IPR020842; KEGG: pac:PPA0372 3-ketoacyl-(acyl-carrier-protein) reductase; PFAM: Short-chain dehydrogenase/reductase SDR; PRIAM: 3-oxoacyl-[acyl-carrier-protein] reductase; SMART: Polyketide synthase/Fatty acid synthase, KR; SPTR: Short-chain dehydrogenase/reductase SDR; IMG reference gene:2503957887; PFAM: short chain dehydrogenase YP_004412158.1 COGs: COG1902 NADH:flavin oxidoreductase Old Yellow Enzyme family; InterPro IPR001155; KEGG: trq:TRQ2_0516 NADH:flavin oxidoreductase/NADH oxidase; PFAM: NADH:flavin oxidoreductase/NADH oxidase, N-terminal; SPTR: NADH:flavin oxidoreductase/NADH oxidase; IMG reference gene:2503957888; PFAM: NADH:flavin oxidoreductase / NADH oxidase YP_004412159.1 COGs: COG1609 Transcriptional regulators; InterPro IPR000843:IPR001761; KEGG: tmt:Tmath_0260 transcriptional regulator, LacI family; PFAM: Periplasmic binding protein/LacI transcriptional regulator; HTH transcriptional regulator, LacI; SMART: HTH transcriptional regulator, LacI; SPTR: uncharacterized protein; IMG reference gene:2503957889; PFAM: Bacterial regulatory proteins, lacI family; family YP_004412160.1 COGs: COG0410 ABC-type branched-chain amino acid transport systems ATPase component; InterPro IPR003439:IPR003593; KEGG: cpy:Cphy_3532 ABC transporter related; PFAM: ABC transporter-like; SMART: ATPase, AAA+ type, core; SPTR: uncharacterized protein; IMG reference gene:2503957890; PFAM: ABC transporter YP_004412161.1 COGs: COG0411 ABC-type branched-chain amino acid transport systems ATPase component; InterPro IPR003439:IPR003593; KEGG: dma:DMR_05820 ABC transporter ATP-binding protein; PFAM: ABC transporter-like; PRIAM: Monosaccharide-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: uncharacterized protein; IMG reference gene:2503957891; PFAM: ABC transporter; Branched-chain amino acid ATP-binding cassette transporter YP_004412162.1 COGs: COG4177 ABC-type branched-chain amino acid transport system permease component; InterPro IPR001851; KEGG: amt:Amet_2076 inner-membrane translocator; PFAM: ABC transporter permease; SPTR: uncharacterized protein; IMG reference gene:2503957892; PFAM: Branched-chain amino acid transport system / permease component YP_004412163.1 COGs: COG0559 Branched-chain amino acid ABC-type transport system permease components; InterPro IPR001851; KEGG: amt:Amet_2075 inner-membrane translocator; PFAM: ABC transporter permease; SPTR: uncharacterized protein; IMG reference gene:2503957893; PFAM: Branched-chain amino acid transport system / permease component YP_004412164.1 COGs: COG0683 ABC-type branched-chain amino acid transport systems periplasmic component; InterPro IPR001828; KEGG: amt:Amet_2074 extracellular ligand-binding receptor; PFAM: Extracellular ligand-binding receptor; SPTR: uncharacterized protein; IMG reference gene:2503957894; PFAM: Receptor family ligand binding region YP_004412165.1 COGs: COG0656 Aldo/keto reductase related to diketogulonate reductase; InterPro IPR023210; KEGG: gtn:GTNG_0505 aldo/keto reductase oxidoreductase; PFAM: NADP-dependent oxidoreductase domain; PRIAM: Methylglyoxal reductase (NADPH-dependent); SPTR: 2,5-didehydrogluconate reductase; manually curated; IMG reference gene:2503957895; PFAM: Aldo/keto reductase YP_004412166.1 COGs: COG1692 conserved hypothetical protein; KEGG: ssm:Spirs_4037 hypothetical protein; SPTR: Metallophosphoesterase; manually curated; IMG reference gene:2503957896; TIGRFAM: metallophosphoesterase, MG_246/BB_0505 family YP_004412167.1 InterPro IPR010664; KEGG: apb:SAR116_1245 hypothetical protein; PFAM: Lipopolysccharide assembly, LptC-related; SPTR: OstA family protein; IMG reference gene:2503957897; PFAM: Protein of unknown function (DUF1239) YP_004412168.1 KEGG: ssm:Spirs_4046 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957898; PFAM: Protein of unknown function (DUF1239) YP_004412169.1 COGs: COG1137 ABC-type (unclassified) transport system ATPase component; InterPro IPR003439:IPR003593; KEGG: sta:STHERM_c21930 transporter; PFAM: ABC transporter-like; PRIAM: Fe(3+)-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: Transporter; IMG reference gene:2503957899; PFAM: ABC transporter YP_004412170.1 COGs: COG1508 DNA-directed RNA polymerase specialized sigma subunit sigma54 homolog; InterPro IPR000394:IPR007046:IPR007634; KEGG: ssm:Spirs_4048 RNA polymerase, sigma 54 subunit, RpoN; PFAM: RNA polymerase sigma factor 54, DNA-binding; RNA polymerase sigma factor 54, core-binding; RNA polymerase sigma factor 54; SPTR: RNA polymerase sigma-54 factor; TIGRFAM: RNA polymerase sigma factor 54; IMG reference gene:2503957900; PFAM: Sigma-54 factor, Activator interacting domain (AID); Sigma-54, DNA binding domain; Sigma-54 factor, core binding domain; TIGRFAM: RNA polymerase sigma-54 factor YP_004412171.1 KEGG: ssm:Spirs_4049 ribosomal subunit interface protein; SPTR: uncharacterized protein; IMG reference gene:2503957901; PFAM: Sigma 54 modulation protein / S30EA ribosomal protein; TIGRFAM: ribosomal subunit interface protein YP_004412172.1 COGs: COG1493 Serine kinase of the HPr protein regulates carbohydrate metabolism; HAMAP: Signal transduction serine kinase/phosphorylase, HPr(Ser) kinase; InterPro IPR003755:IPR011126:IPR011104; KEGG: ssm:Spirs_4050 HPr kinase; PFAM: Signal transduction serine kinase/phosphorylase, HPr(Ser) kinase, C-terminal; Signal transduction serine kinase/phosphorylase, HPr(Ser) kinase, N-terminal; SPTR: HPr kinase; TIGRFAM: Signal transduction serine kinase/phosphorylase, HPr(Ser) kinase; IMG reference gene:2503957902; PFAM: HPr Serine kinase N terminus; HPr Serine kinase C-terminal domain; TIGRFAM: Hpr(Ser) kinase/phosphatase YP_004412173.1 COGs: COG1925 Phosphotransferase system HPr-related protein; InterPro IPR005698; KEGG: ssm:Spirs_4051 phosphotransferase system, phosphocarrier protein HPr; PFAM: Phosphotransferase system, phosphocarrier HPr protein; SPTR: Phosphocarrier protein HPr; TIGRFAM: Phosphotransferase system, phosphocarrier HPr protein; IMG reference gene:2503957903; PFAM: PTS HPr component phosphorylation site; TIGRFAM: Phosphotransferase System HPr (HPr) Family YP_004412174.1 COGs: COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidase); HAMAP: Peptidase S24, LexA repressor; InterPro IPR006200:IPR006199:IPR019759; KEGG: ssm:Spirs_4055 transcriptional repressor, LexA family; PFAM: LexA, DNA-binding domain; Peptidase S24/S26A/S26B, conserved region; SPTR: Transcriptional repressor; TIGRFAM: Peptidase S24, LexA repressor; IMG reference gene:2503957904; PFAM: LexA DNA binding domain; Peptidase S24-like; TIGRFAM: SOS regulatory protein LexA YP_004412175.1 COGs: COG1466 DNA polymerase III delta subunit; InterPro IPR010372; KEGG: ssm:Spirs_4056 DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta; SPTR: uncharacterized protein; IMG reference gene:2503957905; PFAM: DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit YP_004412176.1 COGs: COG0322 Nuclease subunit of the excinuclease complex; HAMAP: Excinuclease ABC, C subunit; InterPro IPR004791:IPR000305:IPR001943:IPR001162; KEGG: ssm:Spirs_4068 excinuclease ABC, C subunit; PFAM: Excinuclease ABC, C subunit, C-terminal; Excinuclease ABC, C subunit, N-terminal; UvrB/UvrC protein; SMART: Excinuclease ABC, C subunit, N-terminal; SPTR: UvrABC system protein C; TIGRFAM: Excinuclease ABC, C subunit; IMG reference gene:2503957906; PFAM: UvrB/uvrC motif; UvrC Helix-hairpin-helix N-terminal; GIY-YIG catalytic domain; TIGRFAM: excinuclease ABC, C subunit YP_004412177.1 KEGG: sta:STHERM_c17700 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957907 YP_004412178.1 COGs: COG1351 alternative thymidylate synthase; HAMAP: Thymidylate synthase ThyX; InterPro IPR003669; KEGG: sta:STHERM_c22080 hypothetical protein; PFAM: Thymidylate synthase ThyX; SPTR: uncharacterized protein; TIGRFAM: Thymidylate synthase ThyX; IMG reference gene:2503957908; PFAM: Thymidylate synthase complementing protein; TIGRFAM: thymidylate synthase, flavin-dependent YP_004412179.1 COGs: COG1385 conserved hypothetical protein; InterPro IPR006700; KEGG: ssm:Spirs_4109 protein of unknown function DUF558; PFAM: Ribosomal RNA small subunit methyltransferase E; SPTR: uncharacterized protein; TIGRFAM: Ribosomal RNA small subunit methyltransferase E; IMG reference gene:2503957909; PFAM: RNA methyltransferase; TIGRFAM: RNA methyltransferase, RsmE family YP_004412180.1 COGs: COG4166 ABC-type oligopeptide transport system periplasmic component; InterPro IPR000914; KEGG: ssm:Spirs_4114 extracellular solute-binding protein family 5; PFAM: Bacterial extracellular solute-binding protein, family 5; SPTR: Bacterial extracellular solute-binding protein, family 5; IMG reference gene:2503957910; PFAM: Bacterial extracellular solute-binding proteins, family 5 Middle YP_004412181.1 COGs: COG1640 4-alpha-glucanotransferase; InterPro IPR003385; KEGG: ssm:Spirs_4115 4-alpha-glucanotransferase; PFAM: Glycoside hydrolase, family 77; PRIAM: 4-alpha-glucanotransferase; SPTR: 4-alpha-glucanotransferase; TIGRFAM: Glycoside hydrolase, family 77; IMG reference gene:2503957911; PFAM: 4-alpha-glucanotransferase; TIGRFAM: 4-alpha-glucanotransferase YP_004412182.1 COGs: COG1329 Transcriptional regulators similar to M. xanthus CarD; InterPro IPR003711; KEGG: ssm:Spirs_4116 transcriptional regulator, CarD family; PFAM: Transcription factor CarD; SPTR: Transcriptional regulatory protein; IMG reference gene:2503957912; PFAM: CarD-like/TRCF domain YP_004412183.1 COGs: COG1211 4-diphosphocytidyl-2-methyl-D-erithritol synthase; InterPro IPR001228; KEGG: ssm:Spirs_4117 4-diphosphocytidyl-2C-methyl-D-erythritolsynthas E; PFAM: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; SPTR: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; IMG reference gene:2503957913; PFAM: Uncharacterized protein family UPF0007; TIGRFAM: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_004412184.1 COGs: COG0245 2C-methyl-D-erythritol 2 4-cyclodiphosphate synthase; HAMAP: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, core; InterPro IPR003526; KEGG: ssm:Spirs_4118 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; PFAM: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, core; PRIAM: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; SPTR: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; TIGRFAM: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, core; IMG reference gene:2503957914; PFAM: YgbB family; TIGRFAM: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase YP_004412185.1 KEGG: ssm:Spirs_4125 hypothetical protein; SPTR: cytoplasmic protein; IMG reference gene:2503957915 YP_004412186.1 COGs: COG3943 Virulence protein; KEGG: clo:HMPREF0868_1371 hypothetical protein; SPTR: Toxin-antitoxin system, toxin component, Fic family; IMG reference gene:2503957917 YP_004412187.1 COGs: COG0480 Translation elongation factors (GTPase); InterProIPR004540:IPR005225:IPR000795:IPR004161:IPR 005517:IPR000640; KEGG: ssm:Spirs_4126 translation elongation factor G; PFAM: Protein synthesis factor, GTP-binding; Translation elongation factor EFTu/EF1A, domain 2; Translation elongation factor EFG/EF2, domain IV; Translation elongation factor EFG/EF2, C-terminal; SMART: Translation elongation factor EFG/EF2, domain IV; Translation elongation factor EFG/EF2, C-terminal; SPTR: Translation elongation factor G; TIGRFAM: Translation elongation factor EFG/EF2; Small GTP-binding protein; IMG reference gene:2503957918; PFAM: Elongation factor Tu domain 2; Elongation factor G C-terminus; Elongation factor Tu GTP binding domain; Elongation factor G, domain IV; TIGRFAM: translation elongation factor EF-G; small GTP-binding protein domain YP_004412188.1 COGs: COG2233 Xanthine/uracil permease; InterPro IPR006043; KEGG: acl:ACL_1377 xanthine/uracil/vitamin C permease; PFAM: Xanthine/uracil/vitamin C permease; SPTR: Xanthine/uracil/vitamin C permease; IMG reference gene:2503957919; PFAM: Permease; TIGRFAM: uracil-xanthine permease YP_004412189.1 InterPro IPR002864; KEGG: dvm:DvMF_1428 acyl-ACP thioesterase; PFAM: Acyl-ACP thioesterase; SPTR: Acyl-ACP thioesterase; IMG reference gene:2503957920; PFAM: Acyl-ACP thioesterase YP_004412190.1 COGs: COG3588 Fructose-1 6-bisphosphate aldolase; InterPro IPR000741; KEGG: fjo:Fjoh_0953 fructose-1,6-bisphosphate aldolase; PFAM: Fructose-bisphosphate aldolase, class-I; SPTR: Fructose-bisphosphate aldolase class 1; IMG reference gene:2503957921; PFAM: Fructose-bisphosphate aldolase class-I YP_004412191.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR000408; KEGG: aeh:Mlg_2687 regulator of chromosome condensation, RCC1; PFAM: Regulator of chromosome condensation, RCC1; SPTR: uncharacterized protein; IMG reference gene:2503957922; PFAM: Regulator of chromosome condensation (RCC1) repeat YP_004412192.1 COGs: COG1131 ABC-type multidrug transport system ATPase component; InterPro IPR003439:IPR003593; KEGG: dfe:Dfer_5189 ABC transporter related; PFAM: ABC transporter-like; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter related; IMG reference gene:2503957923; PFAM: ABC transporter YP_004412193.1 KEGG: ssm:Spirs_3164 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957924 YP_004412194.1 COGs: COG1725 transcriptional regulator protein; InterPro IPR000524; KEGG: ssm:Spirs_3163 transcriptional regulator, GntR family; PFAM: HTH transcriptional regulator, GntR; SMART: HTH transcriptional regulator, GntR; SPTR: GntR family transcriptional regulator; IMG reference gene:2503957925; PFAM: Bacterial regulatory proteins, gntR family YP_004412195.1 IMG reference gene:2503957926 YP_004412196.1 COGs: COG3250 Beta-galactosidase/beta-glucuronidase; InterPro IPR006104:IPR006102:IPR006103:IPR004199; KEGG: rca:Rcas_2493 beta-galactosidase; PFAM: Glycoside hydrolase, family 2, TIM barrel; Glycoside hydrolase, family 2, carbohydrate-binding; Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich; Glycoside hydrolase, family 42, domain 5; SPTR: Beta-galactosidase; IMG reference gene:2503957927; PFAM: domain; Glycosyl hydrolases family 2, TIM barrel domain; Beta galactosidase small chain; Glycosyl hydrolases family 2, sugar binding domain YP_004412197.1 COGs: COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenase; InterPro IPR013154:IPR013149:IPR020843; KEGG: clo:HMPREF0868_1158 GroES-like protein; PFAM: Alcohol dehydrogenase, C-terminal; Alcohol dehydrogenase GroES-like; PRIAM: Alcohol dehydrogenase (NADP(+)); SMART: Polyketide synthase, enoylreductase; SPTR: uncharacterized protein; IMG reference gene:2503957929; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase YP_004412198.1 COGs: COG0523 GTPase (G3E family); InterPro IPR003495; KEGG: apv:Apar_1227 cobalamin synthesis protein P47K; PFAM: Cobalamin (vitamin B12) biosynthesis CobW-like; SPTR: CobW/P47K family protein; IMG reference gene:2503957930; PFAM: CobW/HypB/UreG, nucleotide-binding domain; Cobalamin synthesis protein cobW C-terminal domain YP_004412199.1 COGs: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; InterPro IPR005786:IPR001544; KEGG: cac:CA_C1479 branched-chain amino acid aminotransferase; PFAM: Aminotransferase, class IV; PRIAM: Branched-chain-amino-acid transaminase; SPTR: Branched-chain amino acid aminotransferase, group II; TIGRFAM: Branched-chain amino acid aminotransferase II; IMG reference gene:2503957931; PFAM: Aminotransferase class IV; TIGRFAM: branched-chain amino acid aminotransferase, group II YP_004412200.1 InterPro IPR001647; KEGG: bha:BH0719 TetR/AcrR family transcriptional regulator; PFAM: Transcription regulator, TetR-like, DNA-binding, bacterial/archaeal; SPTR: Transcriptional regulator; IMG reference gene:2503957933; PFAM: Bacterial regulatory proteins, tetR family YP_004412201.1 COGs: COG1171 Threonine dehydratase; InterPro IPR005789:IPR001926:IPR002912; KEGG: bvu:BVU_3892 threonine dehydratase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; Amino acid-binding ACT; SPTR: uncharacterized protein; TIGRFAM: Threonine dehydratase II; IMG reference gene:2503957934; PFAM: ACT domain; Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine dehydratase, medium form YP_004412202.1 InterPro IPR002187; KEGG: chy:CHY_1194 PII family protein; SMART: Nitrogen regulatory protein PII; SPTR: Regulatory protein, P-II family; IMG reference gene:2503957935 YP_004412203.1 COGs: COG1940 Transcriptional regulator/sugar kinase; InterPro IPR000600; KEGG: tte:TTE0761 transcriptional regulator; PFAM: ROK; PRIAM: Glucokinase; SPTR: uncharacterized protein; IMG reference gene:2503957936; PFAM: ROK family YP_004412204.1 COGs: COG0279 Phosphoheptose isomerase; InterPro IPR001347; KEGG: csh:Closa_3796 sugar isomerase (SIS); PFAM: Sugar isomerase (SIS); SPTR: uncharacterized protein; IMG reference gene:2503957937; PFAM: SIS domain YP_004412205.1 COGs: COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain; InterPro IPR001789:IPR000005:IPR018060; KEGG: ssm:Spirs_2649 two component transcriptional regulator, AraC family; PFAM: Signal transduction response regulator, receiver domain; HTH transcriptional regulator, AraC; SMART: Helix-turn-helix, AraC type, DNA binding domain; Signal transduction response regulator, receiver domain; SPTR: Two component transcriptional regulator, AraC family; IMG reference gene:2503957938; PFAM: Response regulator receiver domain; Bacterial regulatory helix-turn-helix proteins, AraC family YP_004412206.1 COGs: COG2972 signal transduction protein with a C-terminal ATPase domain; InterPro IPR010559:IPR003594; KEGG: ssm:Spirs_2648 integral membrane sensor signal transduction histidine kinase; PFAM: Signal transduction histidine kinase, internal region; ATPase-like, ATP-binding domain; SMART: ATPase-like, ATP-binding domain; SPTR: uncharacterized protein; IMG reference gene:2503957939; PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase YP_004412207.1 COGs: COG1129 ABC-type sugar transport system ATPase component; KEGG: ssm:Spirs_2647 monosaccharide-transporting ATPase; SPTR: uncharacterized protein; IMG reference gene:2503957940 YP_004412208.1 COGs: COG1129 ABC-type sugar transport system ATPase component; InterPro IPR003439:IPR003593; KEGG: ssm:Spirs_2646 ABC transporter related protein; PFAM: ABC transporter-like; PRIAM: Monosaccharide-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: uncharacterized protein; IMG reference gene:2503957941; PFAM: ABC transporter YP_004412209.1 COGs: COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems permease components; InterPro IPR001851; KEGG: ssm:Spirs_2645 inner-membrane translocator; PFAM: ABC transporter permease; SPTR: Inner-membrane translocator; IMG reference gene:2503957942; PFAM: Branched-chain amino acid transport system / permease component YP_004412210.1 COGs: COG1879 ABC-type sugar transport system periplasmic component; InterPro IPR001761; KEGG: ssm:Spirs_2644 periplasmic binding protein/LacI transcriptional regulator; PFAM: Periplasmic binding protein/LacI transcriptional regulator; SPTR: Periplasmic binding protein/LacI transcriptional regulator; IMG reference gene:2503957943; PFAM: family YP_004412211.1 InterPro IPR001087; KEGG: bld:BLi04100 hypothetical protein; PFAM: Lipase, GDSL; SPTR: uncharacterized protein; IMG reference gene:2503957944; PFAM: GDSL-like Lipase/Acylhydrolase YP_004412212.1 COGs: COG0406 Fructose-2 6-bisphosphatase; InterPro IPR013078; KEGG: ssm:Spirs_1093 phosphoglycerate mutase; PFAM: Histidine phosphatase superfamily, clade-1; SMART: Histidine phosphatase superfamily, clade-1; SPTR: Alpha-ribazole-5-phosphate phosphatase; IMG reference gene:2503957945; PFAM: Phosphoglycerate mutase YP_004412213.1 COGs: COG4866 conserved hypothetical protein; KEGG: sta:STHERM_c02850 ABC transporter permease; SPTR: ABC transporter, permease; IMG reference gene:2503957946; PFAM: Uncharacterized conserved protein (DUF2156) YP_004412214.1 InterPro IPR000073; KEGG: kko:Kkor_1814 alpha/beta hydrolase fold protein; PFAM: Alpha/beta hydrolase fold-1; SPTR: Hydrolase, alpha/beta domain protein; IMG reference gene:2503957948; PFAM: X-Pro dipeptidyl-peptidase (S15 family) YP_004412215.1 COGs: COG1387 Histidinol phosphatase and related hydrolase of the PHP family; InterPro IPR010140:IPR004013; KEGG: ssm:Spirs_0453 histidinol phosphate phosphatase HisJ family; PFAM: PHP, C-terminal; SPTR: Probable histidinol-phosphatase; TIGRFAM: Histidinol phosphate phosphatase, HisJ; IMG reference gene:2503957949; PFAM: PHP domain; TIGRFAM: histidinol phosphate phosphatase HisJ family YP_004412216.1 COGs: COG1309 Transcriptional regulator; InterPro IPR001647; KEGG: hor:Hore_14700 transcriptional regulator, TetR family; PFAM: Transcription regulator, TetR-like, DNA-binding, bacterial/archaeal; SPTR: Transcriptional regulator, TetR family; IMG reference gene:2503957950; PFAM: Bacterial regulatory proteins, tetR family YP_004412217.1 COGs: COG0474 Cation transport ATPase; InterProIPR006408:IPR001757:IPR004014:IPR008250:IPR 005834:IPR006068; KEGG: swo:Swol_0623 cation transporting ATPase-like protein; PFAM: ATPase, P-type, ATPase-associated domain; ATPase, P-type cation-transporter, N-terminal; Haloacid dehalogenase-like hydrolase; ATPase, P-type cation-transporter, C-terminal; PRIAM: Calcium-transporting ATPase; SMART: ATPase, P-type cation-transporter, N-terminal; SPTR: Cation transporting ATPase-like protein; TIGRFAM: ATPase, P-type, calcium-transporting, PMCA-type; ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter; IMG reference gene:2503957951; PFAM: E1-E2 ATPase; Cation transporting ATPase, C-terminus; Cation transporter/ATPase, N-terminus; haloacid dehalogenase-like hydrolase; TIGRFAM: plasma-membrane calcium-translocating P-type ATPase; ATPase, P-type (transporting), HAD superfamily, subfamily IC YP_004412218.1 KEGG: fjo:Fjoh_3952 hypothetical protein; SPTR: Conserved repeat domain protein; IMG reference gene:2503957952 YP_004412219.1 KEGG: bfr:BF3846 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957953 YP_004412220.1 KEGG: bfr:BF3847 hypothetical protein; SPTR: lipoprotein; IMG reference gene:2503957954 YP_004412221.1 COGs: COG5421 Transposase; InterPro IPR002559; KEGG: cob:COB47_1677 transposase IS4 family protein; PFAM: Transposase, IS4-like; SPTR: Transposase IS4 family protein; IMG reference gene:2503957955; PFAM: Transposase DDE domain YP_004412222.1 COGs: COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; InterPro IPR000792; KEGG: ssm:Spirs_3043 transcriptional regulator, LuxR family; PFAM: Transcription regulator LuxR, C-terminal; SMART: Transcription regulator LuxR, C-terminal; SPTR: two-component response regulator; membrane protein; signal peptide; IMG reference gene:2503957956; PFAM: Bacterial regulatory proteins, luxR family YP_004412223.1 COGs: COG0039 Malate/lactate dehydrogenase; HAMAP: L-lactate dehydrogenase; InterPro IPR011304:IPR001236:IPR022383; KEGG: cth:Cthe_0345 malate dehydrogenase (NAD); PFAM: Lactate/malate dehydrogenase, N-terminal; Lactate/malate dehydrogenase, C-terminal; PRIAM: L-lactate dehydrogenase; SPTR: L-lactate dehydrogenase; TIGRFAM: L-lactate dehydrogenase; IMG reference gene:2503957957; PFAM: lactate/malate dehydrogenase, alpha/beta C-terminal domain; lactate/malate dehydrogenase, NAD binding domain; TIGRFAM: L-lactate dehydrogenase YP_004412224.1 COGs: COG1879 ABC-type sugar transport system periplasmic component; KEGG: cpy:Cphy_2012 periplasmic binding protein/LacI transcriptional regulator; SPTR: uncharacterized protein; IMG reference gene:2503957958 YP_004412225.1 COGs: COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems permease components; InterPro IPR001851; KEGG: cpy:Cphy_2011 monosaccharide-transporting ATPase; PFAM: ABC transporter permease; SPTR: Inner-membrane translocator; IMG reference gene:2503957959; PFAM: Branched-chain amino acid transport system / permease component YP_004412226.1 COGs: COG1129 ABC-type sugar transport system ATPase component; InterPro IPR003439:IPR003593; KEGG: cpy:Cphy_2010 ABC transporter related; PFAM: ABC transporter-like; PRIAM: Monosaccharide-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: uncharacterized protein; IMG reference gene:2503957960; PFAM: ABC transporter YP_004412227.1 COGs: COG1070 Sugar (pentulose and hexulose) kinase; InterPro IPR018484; KEGG: gym:GYMC10_3922 carbohydrate kinase, FGGY-like protein; PFAM: Carbohydrate kinase, FGGY, N-terminal; PRIAM: Rhamnulokinase; SPTR: Carbohydrate kinase, FGGY-like protein; IMG reference gene:2503957961; PFAM: FGGY family of carbohydrate kinases, N-terminal domain; FGGY family of carbohydrate kinases, C-terminal domain YP_004412228.1 COGs: COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenase; InterPro IPR013154:IPR013149; KEGG: csc:Csac_0869 alcohol dehydrogenase; PFAM: Alcohol dehydrogenase, C-terminal; Alcohol dehydrogenase GroES-like; SPTR: Alcohol dehydrogenase, zinc-binding domain protein; IMG reference gene:2503957962; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase YP_004412229.1 COGs: COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase); InterPro IPR002198; KEGG: sta:STHERM_c08270 hypothetical protein; PFAM: Short-chain dehydrogenase/reductase SDR; PRIAM: 3-oxoacyl-[acyl-carrier-protein] reductase; SPTR: uncharacterized protein; IMG reference gene:2503957963; PFAM: short chain dehydrogenase YP_004412230.1 KEGG: sta:STHERM_c08260 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957964 YP_004412231.1 COGs: COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit; InterPro IPR001017:IPR005475:IPR005476; KEGG: sta:STHERM_c08250 dehydrogenase, fusion; PFAM: Transketolase-like, pyrimidine-binding domain; Dehydrogenase, E1 component; Transketolase, C-terminal; PRIAM: Pyruvate dehydrogenase (acetyl-transferring); SMART: Transketolase-like, pyrimidine-binding domain; SPTR: dehydrogenase, fusion; IMG reference gene:2503957965; PFAM: Dehydrogenase E1 component; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain YP_004412232.1 COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterPro IPR006258:IPR013027:IPR004099; KEGG: csc:Csac_0873 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation; PRIAM: Dihydrolipoyl dehydrogenase; SPTR: Dihydrolipoyl dehydrogenase; TIGRFAM: Dihydrolipoamide dehydrogenase; IMG reference gene:2503957966; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase YP_004412233.1 COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterPro IPR000089:IPR004167:IPR001078; KEGG: csc:Csac_0872 dehydrogenase catalytic domain-containing protein; PFAM: 2-oxoacid dehydrogenase acyltransferase, catalytic domain; Biotin/lipoyl attachment; E3 binding; PRIAM: Dihydrolipoyllysine-residue acetyltransferase; SPTR: uncharacterized protein; IMG reference gene:2503957967; PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); e3 binding domain; Biotin-requiring enzyme YP_004412234.1 COGs: COG1349 Transcriptional regulators of sugar metabolism; InterPro IPR001034:IPR014036; KEGG: sta:STHERM_c08230 transcriptional regulatory protein; PFAM: HTH transcriptional regulator, DeoR; HTH transcriptional regulator, DeoR N-terminal; SMART: HTH transcriptional regulator, DeoR N-terminal; SPTR: Transcriptional regulatory protein; IMG reference gene:2503957968; PFAM: Bacterial regulatory proteins, deoR family; DeoR-like helix-turn-helix domain YP_004412235.1 COGs: COG3254 conserved hypothetical protein; InterPro IPR013448:IPR008000; KEGG: bth:BT_4177 hypothetical protein; PFAM: Rhamnose mutarotase; SPTR: uncharacterized protein; TIGRFAM: L-rhamnose 1-epimerase; IMG reference gene:2503957969; PFAM: Domain of unknown function (DUF718); TIGRFAM: L-rhamnose 1-epimerase YP_004412236.1 COGs: COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems permease components; InterPro IPR001851; KEGG: sta:STHERM_c08350 transporter; PFAM: ABC transporter permease; SPTR: Transporter; IMG reference gene:2503957970; PFAM: Branched-chain amino acid transport system / permease component YP_004412237.1 COGs: COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems permease components; InterPro IPR001851; KEGG: oan:Oant_3568 monosaccharide-transporting ATPase; PFAM: ABC transporter permease; SPTR: Monosaccharide-transporting ATPase; IMG reference gene:2503957971; PFAM: Branched-chain amino acid transport system / permease component YP_004412238.1 COGs: COG1129 ABC-type sugar transport system ATPase component; InterPro IPR003439:IPR003593; KEGG: sta:STHERM_c08330 ribose/galactose/methyl galactoside import ATP-bindingprotein; PFAM: ABC transporter-like; PRIAM: Monosaccharide-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ribose/galactose/methyl galactoside import ATP-bindingprotein; IMG reference gene:2503957972; PFAM: ABC transporter YP_004412239.1 COGs: COG1879 ABC-type sugar transport system periplasmic component; InterPro IPR013459; KEGG: sta:STHERM_c08320 transporter; SPTR: Transporter; TIGRFAM: Rhamnose ABC transporter, rhamnose-binding; IMG reference gene:2503957973; PFAM: family; TIGRFAM: rhamnose ABC transporter, rhamnose-binding protein YP_004412240.1 COGs: COG3347 conserved hypothetical protein; InterPro IPR001303; KEGG: sta:STHERM_c08370 short chain dehydrogenase; PFAM: Class II aldolase/adducin, N-terminal; SPTR: Uncharacterized conserved protein; IMG reference gene:2503957974; PFAM: Class II Aldolase and Adducin N-terminal domain YP_004412241.1 COGs: COG4806 L-rhamnose isomerase; InterPro IPR009308; KEGG: csc:Csac_0876 L-rhamnose isomerase; PFAM: Rhamnose isomerase; PRIAM: L-rhamnose isomerase; SPTR: L-rhamnose isomerase; IMG reference gene:2503957975; PFAM: L-rhamnose isomerase (RhaA); TIGRFAM: L-rhamnose isomerase YP_004412242.1 COGs: COG2207 AraC-type DNA-binding domain-containing protein; InterPro IPR003313:IPR000005:IPR018060; KEGG: rba:RB680 L-rhamnose operon transcriptional activator; PFAM: HTH transcriptional regulator, AraC; HTH transcriptional regulator, AraC, arabinose-binding/dimerisation; SMART: Helix-turn-helix, AraC type, DNA binding domain; SPTR: Transcriptional regulator, AraC family; IMG reference gene:2503957976; PFAM: AraC-like ligand binding domain; Bacterial regulatory helix-turn-helix proteins, AraC family YP_004412243.1 COGs: COG1609 Transcriptional regulators; InterPro IPR000843:IPR001761; KEGG: smd:Smed_4315 periplasmic binding protein/LacI transcriptional regulator; PFAM: Periplasmic binding protein/LacI transcriptional regulator; HTH transcriptional regulator, LacI; SMART: HTH transcriptional regulator, LacI; SPTR: Periplasmic binding protein/LacI transcriptional regulator; IMG reference gene:2503957977; PFAM: Bacterial regulatory proteins, lacI family; family YP_004412244.1 COGs: COG4154 Fucose dissimilation pathway protein FucU; InterPro IPR007721; KEGG: pjd:Pjdr2_1349 RbsD or FucU transport; PFAM: D-ribose pyranase RbsD/L-fucose mutarotase FucU; SPTR: Fucose operon protein FucU; IMG reference gene:2503957978; PFAM: RbsD / FucU transport protein family YP_004412245.1 COGs: COG2407 L-fucose isomerase and related protein; HAMAP: L-fucose isomerase; InterPro IPR005763:IPR012888:IPR012889:IPR015888; KEGG: gym:GYMC10_3924 L-fucose isomerase; PFAM: L-fucose isomerase-like, C-terminal; L-fucose isomerase, N-terminal-1; L-fucose isomerase, N-terminal-2; PRIAM: L-fucose isomerase; SPTR: L-fucose isomerase; TIGRFAM: L-fucose isomerase; IMG reference gene:2503957979; PFAM: L-fucose isomerase, C-terminal domain; L-fucose isomerase, first N-terminal domain; L-fucose isomerase, second N-terminal domain; TIGRFAM: L-fucose isomerase YP_004412246.1 COGs: COG0738 Fucose permease; InterPro IPR011701; KEGG: gym:GYMC10_2567 major facilitator superfamily MFS_1; PFAM: Major facilitator superfamily MFS-1; SPTR: Major facilitator superfamily MFS_1; IMG reference gene:2503957980; PFAM: Major Facilitator Superfamily YP_004412247.1 KEGG: sta:STHERM_c21820 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957981; PFAM: Protein of unknown function (DUF1312) YP_004412248.1 COGs: COG0803 ABC-type metal ion transport system periplasmic component/surface adhesin; InterPro IPR006127; KEGG: ccu:Ccur_04310 ABC-type metal ion transport system, periplasmic component/surface adhesin; PFAM: ABC transporter metal-binding lipoprotein; SPTR: Zinc ABC transporter, zinc-binding protein AdcA; IMG reference gene:2503957982; PFAM: Periplasmic solute binding protein family YP_004412249.1 KEGG: ssm:Spirs_0502 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957983 YP_004412250.1 COGs: COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems permease components; InterPro IPR001851; KEGG: aco:Amico_0360 inner-membrane translocator; PFAM: ABC transporter permease; SPTR: Inner-membrane translocator; IMG reference gene:2503957984; PFAM: Branched-chain amino acid transport system / permease component YP_004412251.1 COGs: COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems permease components; InterPro IPR001851; KEGG: ssm:Spirs_0504 inner-membrane translocator; PFAM: ABC transporter permease; SPTR: uncharacterized protein; IMG reference gene:2503957985; PFAM: Branched-chain amino acid transport system / permease component YP_004412252.1 COGs: COG1129 ABC-type sugar transport system ATPase component; InterPro IPR003439:IPR003593; KEGG: ssm:Spirs_0505 ABC transporter related protein; PFAM: ABC transporter-like; PRIAM: Monosaccharide-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: uncharacterized protein; IMG reference gene:2503957986; PFAM: ABC transporter YP_004412253.1 KEGG: ssm:Spirs_0506 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503957987 YP_004412254.1 KEGG: cco:CCC13826_0601 outer membrane protein; SPTR: outer membrane protein; IMG reference gene:2503957988 YP_004412255.1 IMG reference gene:2503957989 YP_004412256.1 COGs: COG0566 rRNA methylase; InterPro IPR004441:IPR013123:IPR001537; KEGG: ssm:Spirs_3194 RNA methyltransferase, TrmH family, group 3; PFAM: tRNA/rRNA methyltransferase, SpoU; RNA 2-O ribose methyltransferase, substrate binding; SMART: RNA 2-O ribose methyltransferase, substrate binding; SPTR: rRNA methylase; TIGRFAM: RNA methyltransferase TrmH, group 3; IMG reference gene:2503957990; PFAM: SpoU rRNA Methylase; RNA 2'-O ribose methyltransferase substrate binding; TIGRFAM: rRNA methylase, , group 3 YP_004412257.1 COGs: COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain; HAMAP: Chaperone DnaJ; InterPro IPR012724:IPR001623:IPR001305:IPR002939; KEGG: ssm:Spirs_3197 chaperone protein DnaJ; PFAM: Chaperone DnaJ, C-terminal; Heat shock protein DnaJ, N-terminal; Heat shock protein DnaJ, cysteine-rich domain; SMART: Heat shock protein DnaJ, N-terminal; SPTR: Chaperone protein DnaJ; TIGRFAM: Chaperone DnaJ; IMG reference gene:2503957991; PFAM: DnaJ C terminal region; DnaJ domain; DnaJ central domain (4 repeats); TIGRFAM: chaperone protein DnaJ YP_004412258.1 COGs: COG0443 Molecular chaperone; HAMAP: Chaperone DnaK; InterPro IPR012725:IPR013126; KEGG: ssm:Spirs_3198 chaperone protein DnaK; PFAM: Heat shock protein 70; SPTR: Chaperone protein dnaK; TIGRFAM: Chaperone DnaK; IMG reference gene:2503957992; PFAM: Hsp70 protein; TIGRFAM: chaperone protein DnaK YP_004412259.1 COGs: COG0576 Molecular chaperone GrpE (heat shock protein); HAMAP: GrpE nucleotide exchange factor; InterPro IPR000740; KEGG: ssm:Spirs_3199 GrpE protein; PFAM: GrpE nucleotide exchange factor; SPTR: Protein grpE; IMG reference gene:2503957993; PFAM: GrpE YP_004412260.1 COGs: COG0281 Malic enzyme; InterPro IPR012301:IPR012302; KEGG: tde:TDE2446 malate dehydrogenase; PFAM: Malic enzyme, NAD-binding; Malic enzyme, N-terminal; PRIAM: Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)); SMART: Malic enzyme, NAD-binding; SPTR: Malate dehydrogenase; IMG reference gene:2503957994; PFAM: Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain YP_004412261.1 InterPro IPR011493; KEGG: azl:AZL_e00660 filamentous haemagglutinin outer membrane protein; SPTR: Filamentous haemagglutinin outer membrane protein; IMG reference gene:2503957995; PFAM: The GLUG motif YP_004412262.1 KEGG: nvi:100119134 similar to conserved hypothetical protein; SPTR: GL17626; IMG reference gene:2503957996 YP_004412263.1 COGs: COG1011 hydrolase (HAD superfamily); InterPro IPR005834; KEGG: ssm:Spirs_3201 haloacid dehalogenase domain protein hydrolase; PFAM: Haloacid dehalogenase-like hydrolase; SPTR: hydrolase of the HAD superfamily; IMG reference gene:2503957997; PFAM: haloacid dehalogenase-like hydrolase YP_004412264.1 COGs: COG1160 GTPase; HAMAP: GTP-binding, EngA; InterPro IPR016484:IPR005225:IPR002917; KEGG: ssm:Spirs_3209 ribosome-associated GTPase EngA; PFAM: GTP-binding protein, HSR1-related; SPTR: GTP-binding protein EngA; TIGRFAM: GTP-binding, EngA; Small GTP-binding protein; IMG reference gene:2503957998; PFAM: GTPase of unknown function; TIGRFAM: ribosome-associated GTPase EngA; small GTP-binding protein domain YP_004412265.1 COGs: COG1080 Phosphoenolpyruvate-protein kinase (PTS system EI component); InterPro IPR006318:IPR008731:IPR008279:IPR000121; KEGG: ssm:Spirs_3210 phosphoenolpyruvate-protein phosphotransferase; PFAM: PEP-utilising enzyme; Phosphotransferase system, PEP-utilising enzyme, N-terminal; PEP-utilising enzyme, mobile domain; PRIAM: Phosphoenolpyruvate--protein phosphotransferase; SPTR: Phosphoenolpyruvate-protein phosphotransferase; TIGRFAM: Phosphoenolpyruvate-protein phosphotransferase; IMG reference gene:2503957999; PFAM: PEP-utilising enzyme, mobile domain; PEP-utilising enzyme, TIM barrel domain; PEP-utilising enzyme, N-terminal; TIGRFAM: phosphoenolpyruvate-protein phosphotransferase YP_004412266.1 InterPro IPR019606; KEGG: sti:Sthe_0621 spore germination protein-like protein; PFAM: GerMN domain; SMART: GerMN domain; SPTR: uncharacterized protein; IMG reference gene:2503958000; PFAM: Sporulation and spore germination YP_004412267.1 COGs: COG1189 rRNA methylase; InterPro IPR004538:IPR002877; KEGG: sta:STHERM_c13010 hemolysin; PFAM: Ribosomal RNA methyltransferase RrmJ/FtsJ; SPTR: Hemolysin; TIGRFAM: Haemolysin A; IMG reference gene:2503958001; PFAM: FtsJ-like methyltransferase; TIGRFAM: hemolysin TlyA family protein YP_004412268.1 COGs: COG1692 conserved hypothetical protein; InterPro IPR005235:IPR004843; KEGG: ssm:Spirs_3213 Ser/Thr protein phosphatase; PFAM: Metallo-dependent phosphatase; SPTR: uncharacterized protein; TIGRFAM: Conserved hypothetical protein CHP00282; IMG reference gene:2503958002; TIGRFAM: metallophosphoesterase, MG_246/BB_0505 family YP_004412269.1 COGs: COG1418 HD superfamily hydrolase; HAMAP: 2',3'-cyclic-nucleotide 2'-phosphodiesterase; InterProIPR017705:IPR006675:IPR018111:IPR006674:IPR 004087:IPR003607; KEGG: ssm:Spirs_3214 metal dependent phosphohydrolase; PFAM: Metal-dependent phosphohydrolase, HD subdomain; K Homology, type 1, subgroup; SMART: Metal-dependent phosphohydrolase, HD domain; K Homology; SPTR: 2',3'-cyclic-nucleotide 2'-phosphodiesterase; TIGRFAM: 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Uncharacterised protein family HDIG; IMG reference gene:2503958003; PFAM: KH domain; HD domain; Domain of unknown function (DUF3552); TIGRFAM: conserved hypothetical protein YmdA/YtgF; uncharacterized domain HDIG YP_004412270.1 COGs: COG0203 Ribosomal protein L17; HAMAP: Ribosomal protein L17; InterPro IPR000456; KEGG: ssm:Spirs_0981 ribosomal protein L17; PFAM: Ribosomal protein L17; SPTR: 50S ribosomal protein L17; TIGRFAM: Ribosomal protein L17; IMG reference gene:2503958004; PFAM: Ribosomal protein L17; TIGRFAM: ribosomal protein L17 YP_004412271.1 COGs: COG0202 DNA-directed RNA polymerase alpha subunit/40 kD subunit; HAMAP: DNA-directed RNA polymerase, alpha subunit; InterProIPR011773:IPR011261:IPR011262:IPR011260:IPR 011263; KEGG: ssm:Spirs_0980 DNA-directed RNA polymerase, alpha subunit; PFAM: RNA polymerase, alpha subunit, C-terminal; DNA-directed RNA polymerase, insert domain; DNA-directed RNA polymerase, dimerisation; SMART: DNA-directed RNA polymerase, RpoA/D/Rpb3-type; SPTR: uncharacterized protein; TIGRFAM: DNA-directed RNA polymerase, alpha subunit; IMG reference gene:2503958005; PFAM: RNA polymerase Rpb3/Rpb11 dimerisation domain; RNA polymerase Rpb3/RpoA insert domain; Bacterial RNA polymerase, alpha chain C terminal domain; TIGRFAM: DNA-directed RNA polymerase, alpha subunit, bacterial and chloroplast-type YP_004412272.1 COGs: COG0522 Ribosomal protein S4 and related protein; InterPro IPR005709:IPR001912:IPR002942:IPR000253; KEGG: ssm:Spirs_0979 ribosomal protein S4; PFAM: RNA-binding S4; Ribosomal protein S4/S9, N-terminal; Forkhead-associated (FHA) domain; SMART: RNA-binding S4; SPTR: 30S ribosomal protein S4; TIGRFAM: Ribosomal protein S4, bacterial-type; IMG reference gene:2503958006; PFAM: Ribosomal protein S4/S9 N-terminal domain; S4 domain; TIGRFAM: ribosomal protein S4, bacterial/organelle type YP_004412273.1 COGs: COG0100 Ribosomal protein S11; InterPro IPR019981:IPR001971; KEGG: ssm:Spirs_0978 30S ribosomal protein S11; PFAM: Ribosomal protein S11; SPTR: 30S ribosomal protein S11; TIGRFAM: Ribosomal protein S11, bacterial-type; IMG reference gene:2503958007; PFAM: Ribosomal protein S11; TIGRFAM: 30S ribosomal protein S11 YP_004412274.1 COGs: COG0099 Ribosomal protein S13; InterPro IPR019980:IPR001892; KEGG: ssm:Spirs_0977 30S ribosomal protein S13; PFAM: Ribosomal protein S13; SPTR: 30S ribosomal protein S13; TIGRFAM: Ribosomal protein S13, bacterial-type; IMG reference gene:2503958008; PFAM: Ribosomal protein S13/S18; TIGRFAM: 30S ribosomal protein S13 YP_004412275.1 HAMAP: Ribosomal protein L36; InterPro IPR000473; KEGG: ssm:Spirs_0976 ribosomal protein L36; PFAM: Ribosomal protein L36; SPTR: 50S ribosomal protein L36; TIGRFAM: Ribosomal protein L36; IMG reference gene:2503958009; PFAM: Ribosomal protein L36; TIGRFAM: ribosomal protein L36, bacterial type YP_004412276.1 COGs: COG0201 Preprotein translocase subunit SecY; InterPro IPR002208; KEGG: ssm:Spirs_0975 preprotein translocase, SecY subunit; PFAM: SecY protein; SPTR: uncharacterized protein; TIGRFAM: SecY protein; IMG reference gene:2503958010; PFAM: eubacterial secY protein; TIGRFAM: preprotein translocase, SecY subunit YP_004412277.1 COGs: COG0200 Ribosomal protein L15; InterPro IPR005749; KEGG: ddf:DEFDS_1754 50S ribosomal protein L15; SPTR: 50S ribosomal protein L15; TIGRFAM: Ribosomal protein L15, bacterial-type; IMG reference gene:2503958011; PFAM: Ribosomal protein L18e/L15; TIGRFAM: ribosomal protein L15, bacterial/organelle YP_004412278.1 InterPro IPR005996:IPR016082; KEGG: llm:llmg_2363 50S ribosomal protein L30; PFAM: Ribosomal protein L30, ferredoxin-like fold domain; SPTR: 50S ribosomal protein L30; TIGRFAM: Ribosomal protein L30, bacterial-type; IMG reference gene:2503958012; PFAM: Ribosomal protein L30p/L7e; TIGRFAM: ribosomal protein L30, bacterial/organelle YP_004412279.1 COGs: COG0098 Ribosomal protein S5; InterPro IPR005712:IPR013810:IPR005324; KEGG: ssm:Spirs_0972 ribosomal protein S5; PFAM: Ribosomal protein S5, N-terminal; Ribosomal protein S5, C-terminal; SPTR: 30S ribosomal protein S5; TIGRFAM: Ribosomal protein S5, bacterial-type; IMG reference gene:2503958013; PFAM: Ribosomal protein S5, N-terminal domain; Ribosomal protein S5, C-terminal domain; TIGRFAM: ribosomal protein S5, bacterial/organelle type YP_004412280.1 COGs: COG0256 Ribosomal protein L18; InterPro IPR004389:IPR005484; KEGG: tde:TDE0783 50S ribosomal protein L18; PFAM: Ribosomal protein L18/L5; SPTR: 50S ribosomal protein L18; TIGRFAM: Ribosomal protein L18, bacterial; IMG reference gene:2503958014; PFAM: Ribosomal L18p/L5e family; TIGRFAM: ribosomal protein L18, bacterial type YP_004412281.1 COGs: COG0097 Ribosomal protein L6P/L9E; InterPro IPR019906:IPR020040; KEGG: ssm:Spirs_0970 ribosomal protein L6; PFAM: Ribosomal protein L6, alpha-beta domain; SPTR: 50S ribosomal protein L6; TIGRFAM: Ribosomal protein L6, bacterial-type; IMG reference gene:2503958015; PFAM: Ribosomal protein L6; TIGRFAM: ribosomal protein L6, bacterial type YP_004412282.1 COGs: COG0096 Ribosomal protein S8; InterPro IPR000630; KEGG: ssm:Spirs_0969 ribosomal protein S8; PFAM: Ribosomal protein S8; SPTR: 30S ribosomal protein S8; IMG reference gene:2503958016; PFAM: Ribosomal protein S8 YP_004412283.1 COGs: COG0199 Ribosomal protein S14; InterPro IPR001209; KEGG: ssm:Spirs_0968 ribosomal protein S14; PFAM: Ribosomal protein S14; SPTR: 30S ribosomal protein S14 type Z; IMG reference gene:2503958017; PFAM: Ribosomal protein S14p/S29e YP_004412284.1 COGs: COG0094 Ribosomal protein L5; InterPro IPR002132; KEGG: ssm:Spirs_0967 ribosomal protein L5; PFAM: Ribosomal protein L5; SPTR: 50S ribosomal protein L5; IMG reference gene:2503958018; PFAM: ribosomal L5P family C-terminus; Ribosomal protein L5 YP_004412285.1 COGs: COG0198 Ribosomal protein L24; InterPro IPR003256:IPR005824; KEGG: ssm:Spirs_0966 ribosomal protein L24; PFAM: KOW; SMART: KOW; SPTR: 50S ribosomal protein L24; TIGRFAM: Ribosomal protein L24; IMG reference gene:2503958019; PFAM: KOW motif; TIGRFAM: ribosomal protein L24, bacterial/organelle YP_004412286.1 COGs: COG0093 Ribosomal protein L14; InterPro IPR005745:IPR000218; KEGG: ssm:Spirs_0965 ribosomal protein L14; PFAM: Ribosomal protein L14b/L23e; SPTR: 50S ribosomal protein L14; TIGRFAM: Ribosomal protein L14, bacterial-type; IMG reference gene:2503958020; PFAM: Ribosomal protein L14p/L23e; TIGRFAM: ribosomal protein L14, bacterial/organelle YP_004412287.1 COGs: COG0186 Ribosomal protein S17; InterPro IPR019984:IPR000266; KEGG: ssm:Spirs_0964 30S ribosomal protein S17; PFAM: Ribosomal protein S17; SPTR: 30S ribosomal protein S17; TIGRFAM: Ribosomal protein S17, bacterial-type; IMG reference gene:2503958021; PFAM: Ribosomal protein S17; TIGRFAM: 30S ribosomal protein S17 YP_004412288.1 InterPro IPR001854; KEGG: ssm:Spirs_0963 ribosomal protein L29; PFAM: Ribosomal protein L29; SPTR: 50S ribosomal protein L29; TIGRFAM: Ribosomal protein L29; IMG reference gene:2503958022; PFAM: Ribosomal L29 protein; TIGRFAM: ribosomal protein L29 YP_004412289.1 COGs: COG0197 Ribosomal protein L16/L10E; HAMAP: Ribosomal protein L16; InterPro IPR000114:IPR016180; KEGG: ssm:Spirs_0962 ribosomal protein L16; PFAM: Ribosomal protein L10e/L16; SPTR: 50S ribosomal protein L16; TIGRFAM: Ribosomal protein L16; IMG reference gene:2503958023; PFAM: Ribosomal protein L16p/L10e; TIGRFAM: ribosomal protein L16, bacterial/organelle YP_004412290.1 COGs: COG0092 Ribosomal protein S3; InterProIPR005704:IPR008282:IPR004044:IPR001351:IPR 004087; KEGG: ssm:Spirs_0961 ribosomal protein S3; PFAM: Ribosomal protein S3, C-terminal; Ribosomal protein S3, N-terminal; K Homology, type 2; SMART: K Homology; SPTR: 30S ribosomal protein S3; TIGRFAM: Ribosomal protein S3, bacterial; IMG reference gene:2503958024; PFAM: KH domain; Ribosomal protein S3, C-terminal domain; Ribosomal protein S3, N-terminal domain; TIGRFAM: ribosomal protein S3, bacterial type YP_004412291.1 COGs: COG0091 Ribosomal protein L22; InterPro IPR005727:IPR001063; KEGG: sta:STHERM_c05010 50S ribosomal protein L22; PFAM: Ribosomal protein L22/L17; SPTR: 50S ribosomal protein L22; TIGRFAM: Ribosomal protein L22, bacterial-type; IMG reference gene:2503958025; PFAM: Ribosomal protein L22p/L17e; TIGRFAM: ribosomal protein L22, bacterial type YP_004412292.1 COGs: COG0185 Ribosomal protein S19; InterPro IPR005732:IPR002222; KEGG: ssm:Spirs_0959 ribosomal protein S19; PFAM: Ribosomal protein S19/S15; SPTR: 30S ribosomal protein S19; TIGRFAM: Ribosomal protein S19, bacterial-type; IMG reference gene:2503958026; PFAM: Ribosomal protein S19; TIGRFAM: ribosomal protein S19, bacterial/organelle YP_004412293.1 COGs: COG0090 Ribosomal protein L2; InterPro IPR005880:IPR022666:IPR022669; KEGG: tde:TDE0770 50S ribosomal protein L2; PFAM: Ribosomal protein L2, C-terminal; Ribosomal Proteins L2, RNA binding domain; SPTR: 50S ribosomal protein L2; TIGRFAM: Ribosomal protein L2, bacterial-type; IMG reference gene:2503958027; PFAM: Ribosomal Proteins L2, RNA binding domain; Ribosomal Proteins L2, C-terminal domain; TIGRFAM: ribosomal protein L2, bacterial/organellar YP_004412294.1 COGs: COG0089 Ribosomal protein L23; InterPro IPR013025; KEGG: ssm:Spirs_0957 ribosomal protein L25/L23; PFAM: Ribosomal protein L25/L23; SPTR: 50S ribosomal protein L23; IMG reference gene:2503958028; PFAM: Ribosomal protein L23 YP_004412295.1 COGs: COG0088 Ribosomal protein L4; InterPro IPR002136; KEGG: ssm:Spirs_0956 ribosomal protein L4/L1e; PFAM: Ribosomal protein L4/L1e; SPTR: 50S ribosomal protein L4; IMG reference gene:2503958029; PFAM: Ribosomal protein L4/L1 family; TIGRFAM: 50S ribosomal protein L4, bacterial/organelle YP_004412296.1 COGs: COG0087 Ribosomal protein L3; InterPro IPR019927:IPR000597; KEGG: ssm:Spirs_0955 50S ribosomal protein L3; PFAM: Ribosomal protein L3; SPTR: 50S ribosomal protein L3; TIGRFAM: Ribosomal protein L3, bacterial/organelle-type; IMG reference gene:2503958030; PFAM: Ribosomal protein L3; TIGRFAM: 50S ribosomal protein L3, bacterial YP_004412297.1 COGs: COG0051 Ribosomal protein S10; HAMAP: Ribosomal protein S10 subgroup; InterPro IPR005731:IPR001848; KEGG: ssm:Spirs_0954 ribosomal protein S10; PFAM: Ribosomal protein S10; SPTR: 30S ribosomal protein S10; TIGRFAM: Ribosomal protein S10 subgroup; IMG reference gene:2503958031; PFAM: Ribosomal protein S10p/S20e; TIGRFAM: ribosomal protein S10, bacterial/organelle YP_004412298.1 COGs: COG0050 GTPase - translation elongation factors; InterProIPR004541:IPR005225:IPR000795:IPR004161:IPR 004160; KEGG: ssm:Spirs_0953 translation elongation factor Tu; PFAM: Protein synthesis factor, GTP-binding; Translation elongation factor EFTu/EF1A, domain 2; Translation elongation factor EFTu/EF1A, C-terminal; SPTR: Elongation factor Tu-B; TIGRFAM: Translation elongation factor EFTu/EF1A, bacterial/organelle; Small GTP-binding protein; IMG reference gene:2503958032; PFAM: Elongation factor Tu domain 2; Elongation factor Tu C-terminal domain; Elongation factor Tu GTP binding domain; TIGRFAM: small GTP-binding protein domain; translation elongation factor TU YP_004412299.1 COGs: COG0049 Ribosomal protein S7; InterPro IPR005717:IPR000235; KEGG: ssm:Spirs_0952 ribosomal protein S7; PFAM: Ribosomal protein S7; SPTR: 30S ribosomal protein S7; TIGRFAM: Ribosomal protein S7, bacterial-type; IMG reference gene:2503958033; PFAM: Ribosomal protein S7p/S5e; TIGRFAM: ribosomal protein S7, bacterial/organelle YP_004412300.1 COGs: COG0048 Ribosomal protein S12; InterPro IPR005679:IPR006032; KEGG: sta:STHERM_c04920 30S ribosomal protein S12; PFAM: Ribosomal protein S12/S23; SPTR: 30S ribosomal protein S12; TIGRFAM: Ribosomal protein S12, bacteria; IMG reference gene:2503958034; PFAM: Ribosomal protein S12; TIGRFAM: ribosomal protein S12, bacterial/organelle YP_004412301.1 COGs: COG0086 DNA-directed RNA polymerase beta' subunit/160 kD subunit; HAMAP: DNA-directed RNA polymerase, subunit beta-prime; InterProIPR012754:IPR007080:IPR000722:IPR007066:IPR 007083:IPR007081:IPR006592; KEGG: ssm:Spirs_0950 DNA-directed RNA polymerase, beta' subunit; PFAM: RNA polymerase Rpb1, domain 1; RNA polymerase, alpha subunit; RNA polymerase Rpb1, domain 3; RNA polymerase Rpb1, domain 4; RNA polymerase Rpb1, domain 5; SMART: RNA polymerase, N-terminal; SPTR: DNA-directed RNA polymerase, beta' subunit; TIGRFAM: DNA-directed RNA polymerase, subunit beta-prime; IMG reference gene:2503958035; PFAM: RNA polymerase Rpb1, domain 2; RNA polymerase Rpb1, domain 4; RNA polymerase Rpb1, domain 1; RNA polymerase Rpb1, domain 3; RNA polymerase Rpb1, domain 5; TIGRFAM: DNA-directed RNA polymerase, beta' subunit, predominant form YP_004412302.1 COGs: COG0085 DNA-directed RNA polymerase beta subunit/140 kD subunit; HAMAP: DNA-directed RNA polymerase, beta subunit, bacterial-type; InterProIPR010243:IPR007644:IPR007642:IPR007645:IPR 019462:IPR007120:IPR007641; KEGG: ssm:Spirs_0949 DNA-directed RNA polymerase, beta subunit; PFAM: DNA-directed RNA polymerase, subunit 2, domain 6; RNA polymerase Rpb2, domain 3; RNA polymerase, beta subunit, protrusion; RNA polymerase Rpb2, domain 2; DNA-directed RNA polymerase, beta subunit, external 1 domain; RNA polymerase Rpb2, domain 7; SPTR: DNA-directed RNA polymerase, beta subunit; TIGRFAM: DNA-directed RNA polymerase, beta subunit, bacterial-type; IMG reference gene:2503958036; PFAM: RNA polymerase Rpb2, domain 3; RNA polymerase Rpb2, domain 6; RNA polymerase beta subunit external 1 domain; RNA polymerase Rpb2, domain 2; RNA polymerase beta subunit; RNA polymerase Rpb2, domain 7; TIGRFAM: DNA-directed RNA polymerase, beta subunit YP_004412303.1 COGs: COG0222 Ribosomal protein L7/L12; HAMAP: Ribosomal protein L7/L12; InterPro IPR000206:IPR013823; KEGG: aeh:Mlg_0450 50S ribosomal protein L7/L12; PFAM: Ribosomal protein L7/L12, C-terminal; SPTR: 50S ribosomal protein L7/L12; TIGRFAM: Ribosomal protein L7/L12; IMG reference gene:2503958037; PFAM: Ribosomal protein L7/L12 C-terminal domain; TIGRFAM: ribosomal protein L7/L12 YP_004412304.1 COGs: COG0244 Ribosomal protein L10; HAMAP: Ribosomal protein L10; InterPro IPR022973:IPR001790; KEGG: ssm:Spirs_0947 ribosomal protein L10; PFAM: Ribosomal protein L10/acidic P0; SPTR: 50S ribosomal protein L10; IMG reference gene:2503958038; PFAM: Ribosomal protein L10 YP_004412305.1 COGs: COG0081 Ribosomal protein L1; InterPro IPR005878:IPR002143; KEGG: ssm:Spirs_0946 ribosomal protein L1; PFAM: Ribosomal protein L1; SPTR: 50S ribosomal protein L1; TIGRFAM: Ribosomal protein L1, bacterial-type; IMG reference gene:2503958039; PFAM: Ribosomal protein L1p/L10e family; TIGRFAM: ribosomal protein L1, bacterial/chloroplast YP_004412306.1 COGs: COG0080 Ribosomal protein L11; InterPro IPR006519:IPR020784:IPR020783:IPR000911; KEGG: sta:STHERM_c04860 50S ribosomal protein L11; PFAM: Ribosomal protein L11, C-terminal domain; Ribosomal protein L11, N-terminal domain; SMART: Ribosomal protein L11; SPTR: 50S ribosomal protein L11; TIGRFAM: Ribosomal protein L11, bacterial-type; IMG reference gene:2503958040; PFAM: Ribosomal protein L11, RNA binding domain; Ribosomal protein L11, N-terminal domain; TIGRFAM: 50S ribosomal protein L11 YP_004412307.1 COGs: COG0250 Transcription antiterminator; InterPro IPR001062:IPR006645:IPR005824; KEGG: ssm:Spirs_0944 NusG antitermination factor; PFAM: Transcription antitermination protein, NusG, N-terminal; KOW; SMART: Transcription antitermination protein, NusG, N-terminal; KOW; SPTR: uncharacterized protein; TIGRFAM: Transcription antitermination protein, NusG; IMG reference gene:2503958041; PFAM: Transcription termination factor nusG; KOW motif; TIGRFAM: transcription termination/antitermination factor NusG YP_004412308.1 InterPro IPR005807:IPR001901; KEGG: ssm:Spirs_0943 preprotein translocase, SecE subunit; PFAM: Protein SecE/Sec61-gamma protein; SPTR: Preprotein translocase subunit SecE; TIGRFAM: SecE subunit of protein translocation complex; IMG reference gene:2503958042; PFAM: SecE/Sec61-gamma subunits of protein translocation complex; TIGRFAM: preprotein translocase, SecE subunit, bacterial YP_004412309.1 HAMAP: Ribosomal protein L33; InterPro IPR001705; KEGG: ssm:Spirs_0942 ribosomal protein L33; PFAM: Ribosomal protein L33; SPTR: 50S ribosomal protein L33; TIGRFAM: Ribosomal protein L33; IMG reference gene:2503958044; PFAM: Ribosomal protein L33; TIGRFAM: ribosomal protein L33, bacterial type YP_004412310.1 COGs: COG0647 sugar phosphatase of the HAD superfamily; InterPro IPR006357:IPR005834; KEGG: ssm:Spirs_3233 HAD-superfamily hydrolase, subfamily IIA; PFAM: Haloacid dehalogenase-like hydrolase; SPTR: Haloacid dehalogenase-like hydrolase, ; TIGRFAM: HAD-superfamily hydrolase, subfamily IIA; IMG reference gene:2503958046; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: HAD-superfamily subfamily IIA hydrolase, TIGR01457; Haloacid Dehalogenase Superfamily Class (subfamily) IIA YP_004412311.1 COGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); InterProIPR006275:IPR005481:IPR005479:IPR005480:IPR 011607; KEGG: sta:STHERM_c07390 carbamoyl-phosphate synthase large chain; PFAM: Carbamoyl-phosphate synthetase, large subunit, ATP-binding; Carbamoyl-phosphate synthase, large subunit, N-terminal; Carbamoyl-phosphate synthetase, large subunit, oligomerisation; Methylglyoxal synthase-like domain; PRIAM: Carbamoyl-phosphate synthase (ammonia); SMART: Methylglyoxal synthase-like domain; SPTR: Carbamoyl-phosphate synthase large chain; TIGRFAM: Carbamoyl-phosphate synthase, large subunit; IMG reference gene:2503958047; PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; MGS-like domain; Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Carbamoyl-phosphate synthase L chain, N-terminal domain; TIGRFAM: carbamoyl-phosphate synthase, large subunit YP_004412312.1 COGs: COG0505 Carbamoylphosphate synthase small subunit; InterPro IPR006274:IPR002474:IPR000991; KEGG: ssm:Spirs_3538 carbamoyl-phosphate synthase, small subunit; PFAM: Glutamine amidotransferase class-I, C-terminal; Carbamoyl-phosphate synthase, small subunit, N-terminal; PRIAM: Carbamoyl-phosphate synthase (glutamine-hydrolyzing); SPTR: Carbamoyl-phosphate synthase small chain; TIGRFAM: Carbamoyl-phosphate synthase, small subunit; IMG reference gene:2503958048; PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phosphate synthase, small subunit YP_004412313.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR013378:IPR011110:IPR000408; KEGG: aeh:Mlg_2687 regulator of chromosome condensation, RCC1; PFAM: Regulator of chromosome condensation, RCC1; Listeria/Bacterioides repeat; Two component regulator propeller; SPTR: uncharacterized protein; IMG reference gene:2503958049; PFAM: Listeria-Bacteroides repeat domain (List_Bact_rpt); Regulator of chromosome condensation (RCC1) repeat YP_004412314.1 InterPro IPR012480; KEGG: csh:Closa_4172 heparinase II/III family protein; PFAM: Heparinase II/III-like; SPTR: uncharacterized protein; IMG reference gene:2503958050; PFAM: Heparinase II/III-like protein YP_004412315.1 InterPro IPR010905; KEGG: rlg:Rleg_5051 glycosyl hydrolase 88; PFAM: Glycosyl hydrolase, family 88; SPTR: Glycosyl hydrolase 88; IMG reference gene:2503958051; PFAM: Glycosyl Hydrolase 88 YP_004412316.1 COGs: COG0395 ABC-type sugar transport system permease component; InterPro IPR000515; KEGG: avi:Avi_7346 ABC transporter membrane spanning protein (sugar); PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Sugar ABC transporter; IMG reference gene:2503958052; PFAM: Binding-protein-dependent transport system inner membrane component YP_004412317.1 COGs: COG1175 ABC-type sugar transport systems permease components; InterPro IPR000515; KEGG: rle:pRL120664 permease component of ABC transporter; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Probable sugar ABC transporter, permease; IMG reference gene:2503958053; PFAM: Binding-protein-dependent transport system inner membrane component YP_004412318.1 IMG reference gene:2503958054 YP_004412319.1 COGs: COG1653 ABC-type sugar transport system periplasmic component; InterPro IPR006059; KEGG: rec:RHECIAT_PC0000519 sugar ABC transporter, substrate-binding protein; PFAM: Bacterial extracellular solute-binding, family 1; SPTR: Extracellular solute-binding protein, family 1; IMG reference gene:2503958055; PFAM: Bacterial extracellular solute-binding protein YP_004412320.1 COGs: COG2972 signal transduction protein with a C-terminal ATPase domain; InterPro IPR003660:IPR010559:IPR003594; KEGG: csh:Closa_1925 integral membrane sensor signal transduction histidine kinase; PFAM: Signal transduction histidine kinase, internal region; HAMP linker domain; ATPase-like, ATP-binding domain; SMART: HAMP linker domain; ATPase-like, ATP-binding domain; SPTR: uncharacterized protein; IMG reference gene:2503958056; PFAM: Histidine kinase; HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase YP_004412321.1 COGs: COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain; InterPro IPR001789:IPR000005:IPR018060; KEGG: csh:Closa_1924 two component transcriptional regulator, AraC family; PFAM: HTH transcriptional regulator, AraC; Signal transduction response regulator, receiver domain; SMART: Helix-turn-helix, AraC type, DNA binding domain; Signal transduction response regulator, receiver domain; SPTR: Two component transcriptional regulator; IMG reference gene:2503958057; PFAM: Response regulator receiver domain; Bacterial regulatory helix-turn-helix proteins, AraC family YP_004412322.1 InterPro IPR012480; KEGG: csh:Closa_1714 heparinase II/III family protein; PFAM: Heparinase II/III-like; SPTR: uncharacterized protein; IMG reference gene:2503958058; PFAM: Heparinase II/III-like protein YP_004412323.1 KEGG: ret:RHE_PF00314 hypothetical protein; SPTR: Hypothetical conserved protein; IMG reference gene:2503958059 YP_004412324.1 COGs: COG1767 Triphosphoribosyl-dephospho-CoA synthetase; InterPro IPR005551:IPR002736; KEGG: aat:D11S_0857 apo-citrate lyase phosphoribosyl-dephospho-CoA transferase/2-(5-triphosphoribosyl)-3-dephosphocoenzyme-A synthase; PFAM: Triphosphoribosyl-dephospho-CoA protein; Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; SPTR: Holo-acyl-carrier-protein synthase; TIGRFAM: Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; IMG reference gene:2503958060; PFAM: Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; ATP:dephospho-CoA triphosphoribosyl transferase; TIGRFAM: holo-ACP synthase CitX YP_004412325.1 COGs: COG3053 Citrate lyase synthetase; InterPro IPR005216:IPR004821:IPR000182:IPR013166; KEGG: fnu:FN0319 citrate (pro-3S)-lyase ligase; PFAM: Citrate lyase ligase, C-terminal; GCN5-related N-acetyltransferase (GNAT) domain; PRIAM: [Citrate (pro-3S)-lyase] ligase; SMART: Citrate lyase ligase, C-terminal; SPTR: [citrate (Pro-3S)-lyase] ligase; TIGRFAM: Citrate lyase ligase; Cytidyltransferase-related; IMG reference gene:2503958061; PFAM: Citrate lyase ligase C-terminal domain; TIGRFAM: [citrate (pro-3S)-lyase] ligase; cytidyltransferase-related domain YP_004412326.1 COGs: COG3180 ammonia monooxygenase; InterPro IPR017516:IPR007820; KEGG: sds:SDEG_0995 ammonia monooxygenase; PFAM: ammonia monooxygenase; SPTR: uncharacterized protein; TIGRFAM: AbrB duplication, membrane protein; IMG reference gene:2503958062; PFAM: ammonia monooxygenase; TIGRFAM: membrane protein AbrB duplication YP_004412327.1 COGs: COG2851 H+/citrate symporter; InterPro IPR014738:IPR004680; KEGG: lsa:LSA1232 citrate:Mg(2+)(H+) symporter; PFAM: Divalent ion symporter; SPTR: Citrate:Mg(2+)(H+) symporter; TIGRFAM: Citrate transporter; IMG reference gene:2503958063; PFAM: Citrate transporter; TIGRFAM: citrate transporter, CitMHS family YP_004412328.1 COGs: COG3051 Citrate lyase alpha subunit; InterPro IPR006472; KEGG: afn:Acfer_0408 citrate lyase, alpha subunit; PFAM: Citrate lyase, alpha subunit; PRIAM: Citrate CoA-transferase; SPTR: Citrate lyase, alpha subunit; TIGRFAM: Citrate lyase, alpha subunit; IMG reference gene:2503958064; PFAM: Citrate lyase, alpha subunit (CitF); TIGRFAM: citrate lyase, alpha subunit YP_004412329.1 COGs: COG2301 Citrate lyase beta subunit; InterPro IPR005000; KEGG: afn:Acfer_0409 citrate (pro-3S)-lyase; PFAM: Aldehyde-lyase domain; PRIAM: Citryl-CoA lyase; SPTR: Citrate lyase, beta subunit; IMG reference gene:2503958065; PFAM: HpcH/HpaI aldolase/citrate lyase; TIGRFAM: citrate lyase, beta subunit YP_004412330.1 COGs: COG3052 Citrate lyase gamma subunit; HAMAP: Citrate lyase acyl carrier protein CitD; InterPro IPR006495; KEGG: afn:Acfer_0410 citrate lyase acyl carrier protein; SPTR: Citrate lyase acyl carrier protein; TIGRFAM: Citrate lyase acyl carrier protein CitD; IMG reference gene:2503958066; PFAM: Malonate decarboxylase delta subunit (MdcD); TIGRFAM: citrate lyase acyl carrier protein YP_004412331.1 COGs: COG0583 Transcriptional regulator; InterPro IPR000847:IPR005119; KEGG: cac:CA_C1046 LysR family transcriptional regulator; PFAM: HTH transcriptional regulator, LysR; LysR, substrate-binding; SPTR: Transcriptional regulator; manually curated; IMG reference gene:2503958067; PFAM: Bacterial regulatory helix-turn-helix protein, lysR family; LysR substrate binding domain YP_004412332.1 COGs: COG0605 Superoxide dismutase; InterPro IPR019831:IPR019832; KEGG: csh:Closa_3787 manganese/iron superoxide dismutase-like protein; PFAM: Manganese/iron superoxide dismutase, C-terminal; Manganese/iron superoxide dismutase, N-terminal; SPTR: Superoxide dismutase; IMG reference gene:2503958068; PFAM: Iron/manganese superoxide dismutases, alpha-hairpin domain; Iron/manganese superoxide dismutases, C-terminal domain YP_004412333.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR000408; KEGG: aeh:Mlg_2687 regulator of chromosome condensation, RCC1; PFAM: Regulator of chromosome condensation, RCC1; SPTR: uncharacterized protein; IMG reference gene:2503958069; PFAM: Regulator of chromosome condensation (RCC1) repeat YP_004412334.1 KEGG: bmq:BMQ_1790 secreted protein; SPTR: secreted protein; IMG reference gene:2503958070 YP_004412335.1 COGs: COG0641 Arylsulfatase regulator (Fe-S oxidoreductase); InterPro IPR007197; KEGG: str:Sterm_2101 radical SAM domain protein; PFAM: Radical SAM; SPTR: uncharacterized protein; IMG reference gene:2503958071; PFAM: Radical SAM superfamily; TIGRFAM: anaerobic sulfatase-maturating enzyme; radical SAM additional 4Fe4S-binding domain YP_004412336.1 InterPro IPR002781; KEGG: ssm:Spirs_3034 protein of unknown function DUF81; PFAM: Protein of unknown function DUF81; SPTR: uncharacterized protein; IMG reference gene:2503958072; PFAM: Sulfite exporter TauE/SafE YP_004412337.1 COGs: COG1506 Dipeptidyl aminopeptidase/acylaminoacyl-peptidase; KEGG: tte:TTE1809 alpha/beta fold family hydrolase; SPTR: Peptidoglycan-binding lysin domain protein; IMG reference gene:2503958073; PFAM: Prolyl oligopeptidase YP_004412338.1 COGs: COG0031 Cysteine synthase; InterPro IPR005856:IPR005859:IPR001926; KEGG: geo:Geob_2530 cysteine synthase A; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; PRIAM: Cysteine synthase; SPTR: Cysteine synthase; TIGRFAM: Cysteine synthase A; Cysteine synthase K/M; IMG reference gene:2503958074; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases YP_004412339.1 COGs: COG2207 AraC-type DNA-binding domain-containing protein; InterPro IPR000005:IPR018060; KEGG: dac:Daci_3532 AraC family transcriptional regulator; PFAM: HTH transcriptional regulator, AraC; SMART: Helix-turn-helix, AraC type, DNA binding domain; SPTR: Transcriptional regulator, AraC family protein; IMG reference gene:2503958075 YP_004412340.1 COGs: COG0822 NifU homolog involved in Fe-S cluster formation; InterPro IPR011341:IPR002871; KEGG: cbe:Cbei_1852 NifU family SUF system FeS assembly protein; PFAM: NIF system FeS cluster assembly, NifU, N-terminal; SPTR: SUF system FeS assembly protein, NifU family; TIGRFAM: SUF system FeS cluster assembly, SufU scaffold; IMG reference gene:2503958076; PFAM: NifU-like N terminal domain; TIGRFAM: SUF system FeS assembly protein, NifU family YP_004412341.1 COGs: COG0520 Selenocysteine lyase; InterPro IPR010970:IPR000192; KEGG: cac:CA_C3291 selenocysteine lyase; PFAM: Aminotransferase, class V/Cysteine desulfurase; PRIAM: Cysteine desulfurase; SPTR: Cysteine desulfurase; TIGRFAM: Cysteine desulfurase, SufS; IMG reference gene:2503958077; PFAM: Aminotransferase class-V; TIGRFAM: cysteine desulfurases, SufS subfamily YP_004412342.1 COGs: COG0719 ABC-type transport system involved in Fe-S cluster assembly permease component; InterPro IPR000825; KEGG: cac:CA_C3290 iron-regulated ABC-type transporter membrane component (SufB); PFAM: SUF system FeS cluster assembly, SufBD; SPTR: FeS assembly protein SufD; IMG reference gene:2503958078; PFAM: Uncharacterized protein family (UPF0051) YP_004412343.1 COGs: COG0719 ABC-type transport system involved in Fe-S cluster assembly permease component; InterPro IPR010231:IPR000825; KEGG: cbe:Cbei_1849 FeS assembly protein SufB; PFAM: SUF system FeS cluster assembly, SufBD; SPTR: FeS assembly protein SufB; TIGRFAM: SUF system FeS cluster assembly, SufB; IMG reference gene:2503958079; PFAM: Uncharacterized protein family (UPF0051); TIGRFAM: FeS assembly protein SufB YP_004412344.1 COGs: COG0396 ABC-type transport system involved in Fe-S cluster assembly ATPase component; InterPro IPR010230:IPR003439:IPR003593; KEGG: vpr:Vpar_1031 FeS assembly ATPase SufC; PFAM: ABC transporter-like; SMART: ATPase, AAA+ type, core; SPTR: FeS assembly ATPase SufC; TIGRFAM: ATPase SufC, SUF system FeS cluster assembly; IMG reference gene:2503958080; PFAM: ABC transporter; TIGRFAM: FeS assembly ATPase SufC YP_004412345.1 COGs: COG0208 Ribonucleotide reductase beta subunit; InterPro IPR000358; KEGG: tde:TDE0335 ribonucleotide-diphosphate reductase subunit beta; PFAM: Ribonucleotide reductase; SPTR: Ribonucleoside-diphosphate reductase, beta subunit; IMG reference gene:2503958081; PFAM: Ribonucleotide reductase, small chain YP_004412346.1 InterPro IPR013346:IPR005144:IPR013509:IPR000788; KEGG: tde:TDE0341 ribonucleotide-diphosphate reductase subunit alpha; PFAM: Ribonucleotide reductase large subunit, C-terminal; Ribonucleotide reductase large subunit, N-terminal; ATP-cone; SPTR: Ribonucleoside-diphosphate reductase; TIGRFAM: Ribonucleoside-diphosphate reductase, alpha subunit; IMG reference gene:2503958082; PFAM: Ribonucleotide reductase, all-alpha domain; ATP cone domain; Ribonucleotide reductase, barrel domain; TIGRFAM: ribonucleoside-diphosphate reductase, alpha subunit YP_004412347.1 COGs: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); HAMAP: AICARFT/IMPCHase bienzyme; InterPro IPR002695:IPR011607:IPR013982; KEGG: sul:SYO3AOP1_1066 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme, transformylase domain; Methylglyoxal synthase-like domain; PRIAM: Phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, transformylase domain; Methylglyoxal synthase-like domain; SPTR: Bifunctional purine biosynthesis protein purH; TIGRFAM: AICARFT/IMPCHase bienzyme; IMG reference gene:2503958083; PFAM: AICARFT/IMPCHase bienzyme; MGS-like domain; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_004412348.1 COGs: COG0334 Glutamate dehydrogenase/leucine dehydrogenase; InterPro IPR006097:IPR006096; KEGG: ssm:Spirs_3994 glutamate dehydrogenase (NADP(+)); PFAM: Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain; PRIAM: Glutamate dehydrogenase (NADP(+)); SMART: Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; SPTR: NAD dependent glutamate dehydrogenase 1; IMG reference gene:2503958084; PFAM: Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Glu/Leu/Phe/Val dehydrogenase, dimerisation domain YP_004412349.1 COGs: COG0367 Asparagine synthase (glutamine-hydrolyzing); InterPro IPR006426:IPR000583:IPR001962; KEGG: fba:FIC_01692 asparagine synthetase B; PFAM: Asparagine synthase; Glutamine amidotransferase, class-II; PRIAM: Asparagine synthase (glutamine-hydrolyzing); SPTR: Asparagine synthetase (Glutamine-hydrolyzing); TIGRFAM: Asparagine synthase, glutamine-hydrolyzing; IMG reference gene:2503958085; PFAM: Asparagine synthase; TIGRFAM: asparagine synthase (glutamine-hydrolyzing) YP_004412350.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR013378:IPR000408; KEGG: aeh:Mlg_2687 regulator of chromosome condensation, RCC1; PFAM: Regulator of chromosome condensation, RCC1; Listeria/Bacterioides repeat; SPTR: uncharacterized protein; IMG reference gene:2503958086; PFAM: Listeria-Bacteroides repeat domain (List_Bact_rpt); Regulator of chromosome condensation (RCC1) repeat YP_004412351.1 COGs: COG4992 Ornithine/acetylornithine aminotransferase; HAMAP: Acetylornithine/succinyldiaminopimelate aminotransferase; InterPro IPR004636:IPR005814; KEGG: eel:EUBELI_00596 acetylornithine aminotransferase; PFAM: Aminotransferase class-III; PRIAM: Acetylornithine transaminase; SPTR: Acetylornithine aminotransferase; TIGRFAM: Acetylornithine/succinylornithine aminotransferase; IMG reference gene:2503958087; PFAM: Aminotransferase class-III; TIGRFAM: acetylornithine and succinylornithine aminotransferases YP_004412352.1 COGs: COG0548 Acetylglutamate kinase; InterPro IPR004662:IPR001048; KEGG: tmt:Tmath_2088 acetylglutamate kinase; PFAM: Aspartate/glutamate/uridylate kinase; PRIAM: Acetylglutamate kinase; SPTR: Acetylglutamate kinase; TIGRFAM: Acetylglutamate kinase; IMG reference gene:2503958088; PFAM: Amino acid kinase; TIGRFAM: acetylglutamate kinase YP_004412353.1 COGs: COG1364 N-acetylglutamate synthase (N-acetylornithine aminotransferase); HAMAP: Arginine biosynthesis protein ArgJ; InterPro IPR002813; KEGG: sth:STH2890 bifunctional ornithine acetyltransferase/N-acetylglutamate synthase; PFAM: Arginine biosynthesis protein ArgJ; PRIAM: Amino-acid N-acetyltransferase; SPTR: uncharacterized protein; TIGRFAM: Arginine biosynthesis protein ArgJ; IMG reference gene:2503958089; PFAM: ArgJ family; TIGRFAM: glutamate N-acetyltransferase/amino-acid acetyltransferase YP_004412354.1 COGs: COG0002 Acetylglutamate semialdehyde dehydrogenase; HAMAP: N-acetyl-gamma-glutamyl-phosphate reductase, type 1; InterPro IPR000706:IPR000534:IPR012280; KEGG: bpb:bpr_I1813 N-acetyl-gamma-glutamyl-phosphate reductase ArgC; PFAM: Semialdehyde dehydrogenase, NAD-binding; Semialdehyde dehydrogenase, dimerisation domain; PRIAM: N-acetyl-gamma-glutamyl-phosphate reductase; SMART: Semialdehyde dehydrogenase, NAD-binding; SPTR: N-acetyl-gamma-glutamyl-phosphate reductase; TIGRFAM: N-acetyl-gamma-glutamyl-phosphate reductase, type 1; IMG reference gene:2503958090; PFAM: Semialdehyde dehydrogenase, dimerisation domain; Semialdehyde dehydrogenase, NAD binding domain; TIGRFAM: N-acetyl-gamma-glutamyl-phosphate reductase, common form YP_004412355.1 COGs: COG1929 Glycerate kinase; InterPro IPR004381; KEGG: cth:Cthe_1592 glycerate kinase; PFAM: Glycerate kinase; PRIAM: Glycerate kinase; SPTR: uncharacterized protein; TIGRFAM: Glycerate kinase; IMG reference gene:2503958091; PFAM: Glycerate kinase; TIGRFAM: glycerate kinase YP_004412356.1 COGs: COG0644 Dehydrogenase (flavoprotein); InterPro IPR002218; KEGG: csh:Closa_4238 glucose-inhibited division protein A; PFAM: Glucose-inhibited division protein A-related; SPTR: Glucose-inhibited division protein A; IMG reference gene:2503958092; PFAM: Pyridine nucleotide-disulphide oxidoreductase YP_004412357.1 KEGG: csh:Closa_4239 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503958093 YP_004412358.1 COGs: COG0145 N-methylhydantoinase A/acetone carboxylase beta subunit; InterPro IPR008040:IPR002821; KEGG: csh:Closa_4240 hydantoinase/oxoprolinase; PFAM: Hydantoinase/oxoprolinase; Hydantoinaseoxoprolinase, N-terminal; SPTR: Hydantoinase/oxoprolinase; IMG reference gene:2503958094; PFAM: Hydantoinase/oxoprolinase; Hydantoinase/oxoprolinase N-terminal region YP_004412359.1 InterPro IPR010656; KEGG: csh:Closa_4241 C4-dicarboxylate anaerobic carrier-like protein; PFAM: TRAP C4-dicarboxylate transport system permease DctM subunit; SPTR: C4-dicarboxylate anaerobic carrier-like protein; IMG reference gene:2503958095; PFAM: Citrate transporter YP_004412360.1 KEGG: csh:Closa_4242 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503958096 YP_004412361.1 KEGG: csh:Closa_4243 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503958097 YP_004412362.1 COGs: COG3968 Uncharacterized protein related to glutamine synthetase; InterPro IPR008146; KEGG: cth:Cthe_0196 glutamine synthetase, catalytic region; PFAM: Glutamine synthetase, catalytic domain; PRIAM: Glutamate--ammonia ligase; SPTR: uncharacterized protein; IMG reference gene:2503958098; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase type III N terminal YP_004412363.1 InterPro IPR005561; KEGG: cth:Cthe_0203 response regulator receiver/ANTAR domain-containing protein; PFAM: ANTAR; SPTR: uncharacterized protein; IMG reference gene:2503958099; PFAM: ANTAR domain YP_004412364.1 COGs: COG0504 CTP synthase (UTP-ammonia lyase); HAMAP: CTP synthase; InterPro IPR004468:IPR017456:IPR000991; KEGG: clj:CLJU_c02200 CTP synthase; PFAM: CTP synthase, N-terminal; Glutamine amidotransferase class-I, C-terminal; PRIAM: CTP synthase; SPTR: CTP synthase; TIGRFAM: CTP synthase; IMG reference gene:2503958100; PFAM: Glutamine amidotransferase class-I; CTP synthase N-terminus; TIGRFAM: CTP synthase YP_004412365.1 COGs: COG1438 Arginine repressor; HAMAP: Arginine repressor; InterPro IPR001669:IPR020900:IPR020899; KEGG: ssm:Spirs_3243 arginine repressor, ArgR; PFAM: Arginine repressor, DNA-binding domain; Arginine repressor, C-terminal; SPTR: Arginine repressor; IMG reference gene:2503958101; PFAM: Arginine repressor, C-terminal domain; Arginine repressor, DNA binding domain; TIGRFAM: arginine repressor YP_004412366.1 COGs: COG0166 Glucose-6-phosphate isomerase; HAMAP: Phosphoglucose isomerase (PGI); InterPro IPR001672; KEGG: ssm:Spirs_3245 phosphoglucose isomerase (PGI); PFAM: Phosphoglucose isomerase (PGI); PRIAM: Glucose-6-phosphate isomerase; SPTR: Glucose-6-phosphate isomerase; IMG reference gene:2503958102; PFAM: Phosphoglucose isomerase YP_004412367.1 SPTR: uncharacterized protein; IMG reference gene:2503958103 YP_004412368.1 COGs: COG0205 6-phosphofructokinase; InterPro IPR000023; KEGG: ssm:Spirs_3247 phosphofructokinase; PFAM: Phosphofructokinase domain; PRIAM: 6-phosphofructokinase; SPTR: Diphosphate--fructose-6-phosphate 1-phosphotransferase; IMG reference gene:2503958104; PFAM: Phosphofructokinase YP_004412369.1 COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR004839; KEGG: ssm:Spirs_1023 aminotransferase class I and II; PFAM: Aminotransferase, class I/classII; SPTR: Aminotransferase; IMG reference gene:2503958105; PFAM: Aminotransferase class I and II YP_004412370.1 COGs: COG0272 NAD-dependent DNA ligase (contains BRCT domain type II); HAMAP: NAD-dependent DNA ligase; InterProIPR001679:IPR013839:IPR004150:IPR004149:IPR 001357:IPR013840; KEGG: ssm:Spirs_1336 DNA ligase, NAD-dependent; PFAM: NAD-dependent DNA ligase, adenylation; NAD-dependent DNA ligase, OB-fold; Zinc-finger, NAD-dependent DNA ligase C4-type; BRCT; PRIAM: DNA ligase (NAD(+)); SMART: NAD-dependent DNA ligase, N-terminal; BRCT; SPTR: DNA ligase; TIGRFAM: NAD-dependent DNA ligase; IMG reference gene:2503958106; PFAM: NAD-dependent DNA ligase OB-fold domain; NAD-dependent DNA ligase adenylation domain; NAD-dependent DNA ligase C4 zinc finger domain; BRCA1 C Terminus (BRCT) domain; TIGRFAM: DNA ligase, NAD-dependent YP_004412371.1 KEGG: bcb:BCB4264_A2969 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503958107 YP_004412372.1 COGs: COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL/CutL homologs; InterPro IPR008274; KEGG: ssm:Spirs_1330 aldehyde oxidase and xanthine dehydrogenase molybdopterin binding protein; PFAM: Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding; SPTR: Aldehyde oxidase and xanthine dehydrogenase; IMG reference gene:2503958108; PFAM: Molybdopterin-binding domain of aldehyde dehydrogenase YP_004412373.1 KEGG: gga:417314 dynein, axonemal, heavy chain 9; SPTR: GE19955; IMG reference gene:2503958109 YP_004412374.1 COGs: COG1319 Aerobic-type carbon monoxide dehydrogenase middle subunit CoxM/CutM homologs; InterPro IPR002346; KEGG: ssm:Spirs_1328 molybdopterin dehydrogenase FAD-binding protein; PFAM: Molybdopterin dehydrogenase, FAD-binding; SPTR: xanthine dehydrogenase subunit, FAD-binding domain protein; IMG reference gene:2503958110; PFAM: FAD binding domain in molybdopterin dehydrogenase YP_004412375.1 COGs: COG0587 DNA polymerase III alpha subunit; InterProIPR004805:IPR004013:IPR011708:IPR004365:IPR 003141; KEGG: ssm:Spirs_1327 DNA polymerase III, alpha subunit; PFAM: Bacterial DNA polymerase III, alpha subunit; PHP, C-terminal; Nucleic acid binding, OB-fold, tRNA/helicase-type; PRIAM: DNA-directed DNA polymerase; SMART: Polymerase/histidinol phosphatase, N-terminal; SPTR: DNA polymerase III subunit alpha; TIGRFAM: DNA polymerase III, alpha subunit; IMG reference gene:2503958111; PFAM: Bacterial DNA polymerase III alpha subunit; PHP domain; TIGRFAM: DNA-directed DNA polymerase III (polc) YP_004412376.1 InterPro IPR003425; KEGG: ssm:Spirs_1326 protein of unknown function YGGT; PFAM: Uncharacterised protein family Ycf19; SPTR: uncharacterized protein; IMG reference gene:2503958112; PFAM: YGGT family YP_004412377.1 COGs: COG1200 RecG-like helicase; InterPro IPR004609:IPR011545:IPR001650:IPR014001; KEGG: ssm:Spirs_1325 ATP-dependent DNA helicase RecG; PFAM: DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Helicase, C-terminal; SMART: DEAD-like helicase, N-terminal; Helicase, C-terminal; SPTR: ATP-dependent DNA helicase RecG; TIGRFAM: DNA helicase, ATP-dependent, RecG; IMG reference gene:2503958113; PFAM: Helicase conserved C-terminal domain; DEAD/DEAH box helicase; TIGRFAM: ATP-dependent DNA helicase RecG YP_004412378.1 COGs: COG0742 N6-adenine-specific methylase; InterPro IPR004398; KEGG: ssm:Spirs_1324 methyltransferase; PFAM: RNA methyltransferase, RsmD; SPTR: Methyltransferase, ; TIGRFAM: RNA methyltransferase, RsmD; IMG reference gene:2503958114; PFAM: Conserved hypothetical protein 95; TIGRFAM: RNA methyltransferase, RsmD family YP_004412379.1 COGs: COG3884 Acyl-ACP thioesterase; InterPro IPR002864; KEGG: dvm:DvMF_1428 acyl-ACP thioesterase; PFAM: Acyl-ACP thioesterase; SPTR: Acyl-ACP thioesterase; IMG reference gene:2503958115; PFAM: Acyl-ACP thioesterase YP_004412380.1 InterPro IPR007236; KEGG: abo:ABO_2672 hypothetical protein; PFAM: SlyX; SPTR: uncharacterized protein; IMG reference gene:2503958116; PFAM: SlyX YP_004412381.1 COGs: COG1773 Rubredoxin; InterPro IPR004039; KEGG: sta:STHERM_c04700 rubredoxin; PFAM: Rubredoxin-type Fe(Cys)4 protein; SPTR: Rubredoxin; IMG reference gene:2503958117; PFAM: Rubredoxin YP_004412382.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; KEGG: aeh:Mlg_2687 regulator of chromosome condensation, RCC1; SPTR: uncharacterized protein; IMG reference gene:2503958118; PFAM: Regulator of chromosome condensation (RCC1) repeat YP_004412383.1 COGs: COG0778 Nitroreductase; InterPro IPR000415; KEGG: csh:Closa_0385 nitroreductase; PFAM: Nitroreductase-like; SPTR: Oxygen-insensitive NADPH nitroreductase; IMG reference gene:2503958119; PFAM: Nitroreductase YP_004412384.1 COGs: COG1619 conserved hypothetical protein; InterPro IPR003507; KEGG: cbl:CLK_2168 LD-carboxypeptidase; PFAM: Peptidase S66, LD-carboxypeptidase A; SPTR: LD-carboxypeptidase; IMG reference gene:2503958120; PFAM: LD-carboxypeptidase YP_004412385.1 COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterProIPR011895:IPR002880:IPR019752:IPR019456:IPR 001450:IPR011766; KEGG: mta:Moth_0064 pyruvate:ferredoxin (flavodoxin) oxidoreductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; 4Fe-4S binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding; PRIAM: Pyruvate dehydrogenase (NADP(+)); SMART: Pyruvate-flavodoxin oxidoreductase, EKR domain; SPTR: Pyruvate-flavodoxin oxidoreductase; TIGRFAM: Pyruvate-flavodoxin oxidoreductase; IMG reference gene:2503958121; PFAM: Domain of unknown function; domain; Pyruvate ferredoxin/flavodoxin oxidoreductase; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric YP_004412386.1 COGs: COG1363 Cellulase M and related protein; InterPro IPR008007; KEGG: amu:Amuc_1103 glutamyl aminopeptidase; PFAM: Peptidase M42; PRIAM: Glutamyl aminopeptidase; SPTR: Glutamyl aminopeptidase; IMG reference gene:2503958122; PFAM: M42 glutamyl aminopeptidase YP_004412387.1 COGs: COG5476 conserved hypothetical protein; InterPro IPR015995:IPR010799; KEGG: ssm:Spirs_1401 microcystin LR degradation protein MlrC; PFAM: Microcystin LR degradation protein MlrC, N-terminal; Microcystin LR degradation protein MlrC, C-terminal; SPTR: MlrC domain protein; IMG reference gene:2503958123; PFAM: MlrC C-terminus; Protein of unknown function (DUF1485) YP_004412388.1 COGs: COG3142 Uncharacterized protein involved in copper resistance; InterPro IPR005627; KEGG: ssm:Spirs_1399 CutC family protein; PFAM: CutC; SPTR: CutC family protein Copper transport; IMG reference gene:2503958124; PFAM: CutC family YP_004412389.1 InterPro IPR002192; KEGG: ssm:Spirs_3995 response regulator receiver protein; PFAM: Pyruvate phosphate dikinase, PEP/pyruvate-binding; SPTR: Phosphoenolpyruvate synthase/pyruvate phosphate dikinase; IMG reference gene:2503958125; PFAM: Pyruvate phosphate dikinase, PEP/pyruvate binding domain YP_004412390.1 COGs: COG1082 Sugar phosphate isomerase/epimerase; InterPro IPR012307:IPR011418; KEGG: ssm:Spirs_0709 xylose isomerase domain protein TIM barrel; PFAM: Xylose isomerase, TIM barrel domain; AP endonuclease, family 2, C-terminal; SPTR: uncharacterized protein; IMG reference gene:2503958126; PFAM: AP endonuclease 2 C terminus; Xylose isomerase-like TIM barrel YP_004412391.1 COGs: COG0673 dehydrogenase and related protein; InterPro IPR000683:IPR004104; KEGG: ssm:Spirs_0708 oxidoreductase domain protein; PFAM: Oxidoreductase, N-terminal; Oxidoreductase, C-terminal; SPTR: Oxidoreductase domain protein; IMG reference gene:2503958127; PFAM: Oxidoreductase, NAD-binding Rossmann fold; Oxidoreductase, C-terminal alpha/beta domain YP_004412392.1 COGs: COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems permease components; InterPro IPR001851; KEGG: ssm:Spirs_0707 inner-membrane translocator; PFAM: ABC transporter permease; SPTR: Inner-membrane translocator; IMG reference gene:2503958128; PFAM: Branched-chain amino acid transport system / permease component YP_004412393.1 COGs: COG1129 ABC-type sugar transport system ATPase component; InterPro IPR003439:IPR003593; KEGG: ssm:Spirs_0706 ABC transporter related protein; PFAM: ABC transporter-like; PRIAM: Monosaccharide-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter related; IMG reference gene:2503958129; PFAM: ABC transporter YP_004412394.1 COGs: COG1879 ABC-type sugar transport system periplasmic component; KEGG: ssm:Spirs_0705 periplasmic binding protein/LacI transcriptional regulator; SPTR: Periplasmic binding protein/LacI transcriptional regulator; IMG reference gene:2503958130 YP_004412395.1 COGs: COG1609 Transcriptional regulators; InterPro IPR000843:IPR001761; KEGG: ssm:Spirs_0704 transcriptional regulator, LacI family; PFAM: Periplasmic binding protein/LacI transcriptional regulator; HTH transcriptional regulator, LacI; SMART: HTH transcriptional regulator, LacI; SPTR: HTH-type transcriptional repressor cytR; IMG reference gene:2503958131; PFAM: Bacterial regulatory proteins, lacI family; family YP_004412396.1 COGs: COG0564 Pseudouridylate synthase 23S RNA-specific; InterPro IPR006145; KEGG: ssm:Spirs_4002 pseudouridine synthase; PFAM: Pseudouridine synthase, RsuA and RluB/C/D/E/F; SPTR: Pseudouridine synthase; IMG reference gene:2503958132; PFAM: RNA pseudouridylate synthase YP_004412397.1 COGs: COG0188 Type IIA topoisomerase (DNA gyrase/topo II topoisomerase IV) A subunit; InterPro IPR002205; KEGG: ssm:Spirs_4003 DNA topoisomerase (ATP-hydrolyzing); PFAM: DNA topoisomerase, type IIA, subunit A/C-terminal; PRIAM: DNA topoisomerase (ATP-hydrolyzing); SMART: DNA topoisomerase, type IIA, subunit A/C-terminal; SPTR: Topoisomerase IV, A subunit, ; IMG reference gene:2503958133; PFAM: DNA gyrase/topoisomerase IV, subunit A YP_004412398.1 COGs: COG0187 Type IIA topoisomerase (DNA gyrase/topo II topoisomerase IV) B subunit; InterPro IPR003594:IPR013506:IPR001241; KEGG: ssm:Spirs_4004 DNA topoisomerase type IIA subunit B region 2 domain protein; PFAM: DNA topoisomerase, type IIA, subunit B, domain 2; ATPase-like, ATP-binding domain; SMART: DNA topoisomerase, type IIA, subunit B/N-terminal; ATPase-like, ATP-binding domain; SPTR: DNA topoisomerase 4 subunit B; IMG reference gene:2503958134; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; DNA gyrase B; DNA gyrase B subunit, carboxyl terminus YP_004412399.1 COGs: COG0668 Small-conductance mechanosensitive channel; InterPro IPR006685; KEGG: fbl:Fbal_2937 MscS mechanosensitive ion channel; PFAM: Mechanosensitive ion channel MscS; SPTR: Small-conductance mechanosensitive channel; IMG reference gene:2503958135; PFAM: Mechanosensitive ion channel YP_004412400.1 COGs: COG0326 Molecular chaperone HSP90 family; HAMAP: Chaperone protein HtpG; InterPro IPR001404:IPR003594:IPR020576; KEGG: ssm:Spirs_0285 heat shock protein HSP90; PFAM: Heat shock protein Hsp90, C-terminal; ATPase-like, ATP-binding domain; SMART: ATPase-like, ATP-binding domain; SPTR: Chaperone protein htpG; IMG reference gene:2503958136; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Hsp90 protein YP_004412401.1 COGs: COG1940 Transcriptional regulator/sugar kinase; InterPro IPR000600; KEGG: tle:Tlet_1118 ROK family protein; PFAM: ROK; SPTR: ROK family protein; IMG reference gene:2503958137; PFAM: ROK family YP_004412402.1 KEGG: sta:STHERM_c03850 GTP-binding protein; SPTR: GTP-binding protein; IMG reference gene:2503958138 YP_004412403.1 COGs: COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; InterPro IPR006268:IPR006218:IPR001086:IPR002912; KEGG: ssm:Spirs_0275 phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I/KDSA; Prephenate dehydratase; Amino acid-binding ACT; PRIAM: 3-deoxy-7-phosphoheptulonate synthase., Prephenate dehydratase; SPTR: uncharacterized protein; TIGRFAM: Phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 2; IMG reference gene:2503958139; PFAM: Prephenate dehydratase; ACT domain; DAHP synthetase I family; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase YP_004412404.1 COGs: COG0177 EndoIII-related endonuclease; InterPro IPR003265:IPR003651; KEGG: dol:Dole_2166 DNA-(apurinic or apyrimidinic site) lyase; PFAM: HhH-GPD domain; Endonuclease III-like, iron-sulphur cluster loop motif; PRIAM: DNA-(apurinic or apyrimidinic site) lyase; SMART: HhH-GPD domain; SPTR: DNA-(Apurinic or apyrimidinic site) lyase; IMG reference gene:2503958140; PFAM: HhH-GPD superfamily base excision DNA repair protein; Helix-hairpin-helix motif; TIGRFAM: endonuclease III YP_004412405.1 InterPro IPR011493; KEGG: avn:Avin_37890 filamentous hemagglutinin domain-containing protein; SPTR: Filamentous hemagglutinin domain-containing protein; IMG reference gene:2503958141; PFAM: The GLUG motif YP_004412406.1 KEGG: azl:AZL_026760 major facilitator transporter; SPTR: Major facilitator transporter; IMG reference gene:2503958142 YP_004412407.1 COGs: COG3323 conserved hypothetical protein; KEGG: pag:PLES_12181 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503958143 YP_004412408.1 COGs: COG0193 Peptidyl-tRNA hydrolase; HAMAP: Peptidyl-tRNA hydrolase; InterPro IPR001328; KEGG: ssm:Spirs_0270 peptidyl-tRNA hydrolase; PFAM: Peptidyl-tRNA hydrolase; PRIAM: Aminoacyl-tRNA hydrolase; SPTR: Peptidyl-tRNA hydrolase; TIGRFAM: Peptidyl-tRNA hydrolase; IMG reference gene:2503958144; PFAM: Peptidyl-tRNA hydrolase; TIGRFAM: peptidyl-tRNA hydrolase YP_004412409.1 COGs: COG0366 Glycosidase; InterPro IPR006047:IPR006589; KEGG: ssm:Spirs_0266 alpha amylase catalytic region; PFAM: Glycosyl hydrolase, family 13, catalytic domain; SMART: Glycosyl hydrolase, family 13, subfamily, catalytic domain; SPTR: Alpha amylase catalytic region; IMG reference gene:2503958145; PFAM: Alpha amylase, catalytic domain YP_004412410.1 COGs: COG1301 Na+/H+-dicarboxylate symporter; KEGG: ssm:Spirs_0263 transporter, SPTR: Transporter, ; IMG reference gene:2503958146; PFAM: Sodium:dicarboxylate symporter family YP_004412411.1 KEGG: rci:RRC456 Na(+)/H(+) antiporter; SPTR: uncharacterized protein; IMG reference gene:2503958147 YP_004412412.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR000408; KEGG: aeh:Mlg_2687 regulator of chromosome condensation, RCC1; PFAM: Regulator of chromosome condensation, RCC1; SPTR: Regulator of chromosome condensation, RCC1; IMG reference gene:2503958148; PFAM: Regulator of chromosome condensation (RCC1) repeat YP_004412413.1 COGs: COG0006 Xaa-Pro aminopeptidase; InterPro IPR000587:IPR000994; KEGG: ssm:Spirs_0211 peptidase M24; PFAM: Peptidase M24, structural domain; Creatinase; SPTR: Peptidase, M24 family protein; IMG reference gene:2503958149; PFAM: Metallopeptidase M24; Creatinase/Prolidase N-terminal domain YP_004412414.1 COGs: COG0682 Prolipoprotein diacylglyceryltransferase; HAMAP: Prolipoprotein diacylglyceryl transferase; InterPro IPR001640; KEGG: ssm:Spirs_0157 prolipoprotein diacylglyceryl transferase; PFAM: Prolipoprotein diacylglyceryl transferase; SPTR: Prolipoprotein diacylglyceryl transferase; TIGRFAM: Prolipoprotein diacylglyceryl transferase; manually curated; IMG reference gene:2503958150; PFAM: Prolipoprotein diacylglyceryl transferase; TIGRFAM: prolipoprotein diacylglyceryl transferase YP_004412415.1 COGs: COG0793 Periplasmic protease; InterPro IPR004447:IPR001478:IPR005151; KEGG: ssm:Spirs_0153 carboxyl-terminal protease; PFAM: Peptidase S41; PDZ/DHR/GLGF; SMART: Peptidase S41; PDZ/DHR/GLGF; SPTR: Carboxy-terminal-processing protease; TIGRFAM: Peptidase S41A, C-terminal peptidase; IMG reference gene:2503958151; PFAM: Peptidase S41; PDZ domain (Also known as DHR or GLGF); TIGRFAM: C-terminal peptidase (prc) YP_004412416.1 COGs: COG1385 conserved hypothetical protein; InterPro IPR006700; KEGG: ssm:Spirs_0151 protein of unknown function DUF558; PFAM: Ribosomal RNA small subunit methyltransferase E; SPTR: RNA methyltransferase; TIGRFAM: Ribosomal RNA small subunit methyltransferase E; IMG reference gene:2503958152; PFAM: RNA methyltransferase; TIGRFAM: RNA methyltransferase, RsmE family YP_004412417.1 COGs: COG0675 Transposase and inactivated derivatives; InterPro IPR010095:IPR001959; KEGG: xfm:Xfasm12_1563 transposase OrfB; PFAM: Transposase, probable, IS891/IS1136/IS1341; Transposase, IS605 OrfB, C-terminal; SPTR: Transposase OrfB; TIGRFAM: Transposase, IS605 OrfB, C-terminal; IMG reference gene:2503958159; PFAM: Helix-turn-helix domain; transposase DNA-binding domain; Probable transposase; TIGRFAM: transposase, IS605 OrfB family, central region YP_004412418.1 COGs: COG2452 site-specific integrase-resolvase; InterPro IPR000551:IPR006119; KEGG: xfm:Xfasm12_1564 hypothetical protein; PFAM: Resolvase, N-terminal; HTH transcriptional regulator, MerR; SMART: Resolvase, N-terminal; SPTR: uncharacterized protein; IMG reference gene:2503958160; PFAM: MerR family regulatory protein; Resolvase, N terminal domain YP_004412419.1 KEGG: har:HEAR2257 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503958161 YP_004412420.1 COGs: COG2812 DNA polymerase III gamma/tau subunits; InterPro IPR012763:IPR003959:IPR003593; KEGG: ssm:Spirs_0088 DNA polymerase III, subunits gamma and tau; PFAM: ATPase, AAA-type, core; SMART: ATPase, AAA+ type, core; SPTR: uncharacterized protein; TIGRFAM: DNA polymerase III, subunit gamma/ tau; IMG reference gene:2503958162; PFAM: ATPase associated with various cellular activities (AAA); DNA polymerase III subunits gamma and tau domain III; TIGRFAM: DNA polymerase III, delta' subunit; DNA polymerase III, subunit gamma and tau YP_004412421.1 COGs: COG0353 Recombinational DNA repair protein (RecF pathway); HAMAP: RecR protein; InterPro IPR000093:IPR015967:IPR006171; KEGG: ssm:Spirs_0086 recombination protein RecR; PFAM: Toprim domain; Zinc finger C4-type, RecR; SMART: Toprim domain; SPTR: Recombination protein recR; TIGRFAM: RecR protein; IMG reference gene:2503958163; PFAM: Toprim domain; RecR protein; TIGRFAM: recombination protein RecR YP_004412422.1 KEGG: coc:Coch_0352 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503958164 YP_004412423.1 KEGG: pfh:PFHG_02927 conserved hypothetical protein; SPTR: Conserved Plasmodium protein; IMG reference gene:2503958165 YP_004412424.1 COGs: COG3717 5-keto 4-deoxyuronate isomerase; HAMAP: 5-keto 4-deoxyuronate isomerase; InterPro IPR007045:IPR021120; KEGG: csh:Closa_3486 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; PFAM: KduI/IolB isomerase; PRIAM: 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; SPTR: 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; IMG reference gene:2503958166; PFAM: KduI/IolB family YP_004412425.1 COGs: COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase); InterPro IPR002198; KEGG: snt:SPT_0369 gluconate 5-dehydrogenase; PFAM: Short-chain dehydrogenase/reductase SDR; PRIAM: Gluconate 5-dehydrogenase; SPTR: Gluconate 5-dehydrogenase (5-keto-D-gluconate 5-reductase); IMG reference gene:2503958167; PFAM: short chain dehydrogenase YP_004412426.1 COGs: COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain; InterPro IPR001623; KEGG: dat:HRM2_24840 DjlA; PFAM: Heat shock protein DnaJ, N-terminal; SMART: Heat shock protein DnaJ, N-terminal; SPTR: DjlA; IMG reference gene:2503958168; PFAM: DnaJ domain; Tellurite resistance protein TerB YP_004412427.1 COGs: COG1626 Neutral trehalase; KEGG: ssm:Spirs_0085 hypothetical protein; SPTR: uncharacterized protein; IMG reference gene:2503958169; PFAM: Trehalase YP_004412428.1 COGs: COG1597 Sphingosine kinase; InterPro IPR001206:IPR005218; KEGG: ssm:Spirs_3801 diacylglycerol kinase catalytic region; PFAM: Diacylglycerol kinase, catalytic domain; SMART: Diacylglycerol kinase, catalytic domain; SPTR: Diacylglycerol kinase catalytic region; TIGRFAM: Diacylglycerol/lipid kinase; IMG reference gene:2503958170; PFAM: Diacylglycerol kinase catalytic domain; TIGRFAM: lipid kinase, YegS/Rv2252/BmrU family YP_004412429.1 COGs: COG0534 Na+-driven multidrug efflux pump; InterPro IPR002528; KEGG: ssm:Spirs_0042 MATE efflux family protein; PFAM: Multi antimicrobial extrusion protein; SPTR: MATE efflux family protein; TIGRFAM: Multi antimicrobial extrusion protein; IMG reference gene:2503958171; PFAM: MatE; TIGRFAM: efflux protein, MATE family YP_004412430.1 COGs: COG1820 N-acetylglucosamine-6-phosphate deacetylase; InterPro IPR006680:IPR003764; KEGG: ssm:Spirs_1362 N-acetylglucosamine-6-phosphate deacetylase; PFAM: Amidohydrolase 1; PRIAM: N-acetylglucosamine-6-phosphate deacetylase; SPTR: N-acetylglucosamine-6-phosphate deacetylase; TIGRFAM: N-acetylglucosamine-6-phosphate deacetylase; IMG reference gene:2503958172; PFAM: Amidohydrolase; TIGRFAM: N-acetylglucosamine-6-phosphate deacetylase YP_004412431.1 COGs: COG2195 Di- and tripeptidase; InterPro IPR002933:IPR011650:IPR001160; KEGG: ssm:Spirs_0034 aminoacyl-histidine dipeptidase; PFAM: Peptidase M20, dimerisation; Peptidase M20; PRIAM: Xaa-His dipeptidase; SPTR: Aminoacyl-histidine dipeptidase; TIGRFAM: Peptidase M20C, Xaa-His dipeptidase; IMG reference gene:2503958173; PFAM: Peptidase M20/M25/M40; Peptidase dimerisation domain; TIGRFAM: aminoacyl-histidine dipeptidase YP_004412432.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR000408; KEGG: aeh:Mlg_2687 regulator of chromosome condensation, RCC1; PFAM: Regulator of chromosome condensation, RCC1; SPTR: uncharacterized protein; IMG reference gene:2503958174; PFAM: Regulator of chromosome condensation (RCC1) repeat YP_004412433.1 COGs: COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase; InterPro IPR002123; KEGG: ssm:Spirs_0330 phospholipid/glycerol acyltransferase; PFAM: Phospholipid/glycerol acyltransferase; SMART: Phospholipid/glycerol acyltransferase; SPTR: uncharacterized protein; IMG reference gene:2503958175; PFAM: Acyltransferase; TIGRFAM: 1-acyl-sn-glycerol-3-phosphate acyltransferases YP_004412434.1 COGs: COG0786 Na+/glutamate symporter; KEGG: ssm:Spirs_2474 Na+/glutamate symporter-like protein; SPTR: Na+/glutamate symporter-like protein; IMG reference gene:2503958176 YP_004412435.1 COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; InterPro IPR013378:IPR011110:IPR000408; KEGG: aeh:Mlg_2687 regulator of chromosome condensation, RCC1; PFAM: Regulator of chromosome condensation, RCC1; Listeria/Bacterioides repeat; Two component regulator propeller; SPTR: uncharacterized protein; IMG reference gene:2503958177; PFAM: Listeria-Bacteroides repeat domain (List_Bact_rpt); Regulator of chromosome condensation (RCC1) repeat YP_004412436.1 COGs: COG0426 flavoprotein; InterPro IPR001279:IPR008254; KEGG: ssm:Spirs_0020 uncharacterized flavoprotein; PFAM: Beta-lactamase-like; Flavodoxin/nitric oxide synthase; SMART: Beta-lactamase-like; SPTR: Beta-lactamase-like; IMG reference gene:2503958178; PFAM: Metallo-beta-lactamase superfamily; Flavodoxin YP_004412437.1 COGs: COG1451 metal-dependent hydrolase; InterPro IPR002725; KEGG: abo:ABO_2745 hypothetical protein; PFAM: Protein of unknown function DUF45; SPTR: uncharacterized protein; IMG reference gene:2503958179; PFAM: Protein of unknown function DUF45 YP_004412438.1 COGs: COG2431 membrane protein; InterPro IPR005642; KEGG: ssm:Spirs_0011 protein of unknown function DUF340 membrane; PFAM: Protein of unknown function DUF340, prokaryotic membrane; SPTR: surface protein; IMG reference gene:2503958180; PFAM: Membrane protein of unknown function (DUF340) YP_004412439.1 COGs: COG1916 Uncharacterized homolog of PrgY (pheromone shutdown protein); InterPro IPR002816:IPR005230; KEGG: ssm:Spirs_4297 TraB family protein; PFAM: Pheromone shutdown-related, TraB; SPTR: TraB family protein; TIGRFAM: Pheromone shutdown, TraB; IMG reference gene:2503958181; PFAM: TraB family; TIGRFAM: pheromone shutdown-related protein TraB YP_004412440.1 COGs: COG1066 ATP-dependent serine protease; InterPro IPR004504:IPR003593; KEGG: ssm:Spirs_4298 DNA repair protein RadA; SMART: ATPase, AAA+ type, core; SPTR: DNA repair protein radA; TIGRFAM: DNA repair protein RadA; IMG reference gene:2503958182; PFAM: KaiC; TIGRFAM: DNA repair protein RadA YP_004412441.1 COGs: COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family; InterPro IPR002130:IPR001179; KEGG: dps:DP1645 peptidyl-prolyl cis-trans isomerase; PFAM: Peptidyl-prolyl cis-trans isomerase, cyclophilin-type; Peptidyl-prolyl cis-trans isomerase, FKBP-type; PRIAM: Peptidylprolyl isomerase; SPTR: Probable peptidyl-prolyl cis-trans isomerase; IMG reference gene:2503958183; PFAM: FKBP-type peptidyl-prolyl cis-trans isomerase; Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD YP_004412442.1 COGs: COG1475 transcriptional regulator protein; InterPro IPR003115:IPR004437; KEGG: ssm:Spirs_4300 ParB-like partition protein; PFAM: ParB-like nuclease; SMART: ParB-like nuclease; SPTR: ParB family protein; TIGRFAM: ParB-like partition protein; IMG reference gene:2503958184; PFAM: ParB-like nuclease domain; KorB domain; TIGRFAM: ParB-like partition proteins YP_004412443.1 COGs: COG1192 ATPase involved in chromosome partitioning; InterPro IPR002586; KEGG: ssm:Spirs_4301 cobyrinic acid ac-diamide synthase; PFAM: Cobyrinic acid a,c-diamide synthase; SPTR: uncharacterized protein; IMG reference gene:2503958185; PFAM: CobQ/CobB/MinD/ParA nucleotide binding domain YP_004412444.1 COGs: COG0694 Thioredoxin-like protein and domains; InterPro IPR001075; KEGG: ssm:Spirs_4302 nitrogen-fixing NifU domain protein; PFAM: NIF system FeS cluster assembly, NifU, C-terminal; SPTR: Nitrogen-fixing NifU domain protein; IMG reference gene:2503958186; PFAM: NifU-like domain YP_004412445.1 COGs: COG0188 Type IIA topoisomerase (DNA gyrase/topo II topoisomerase IV) A subunit; InterPro IPR002205:IPR006691:IPR005743; KEGG: ssm:Spirs_4305 DNA gyrase, A subunit; PFAM: DNA topoisomerase, type IIA, subunit A/C-terminal; DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel; PRIAM: DNA topoisomerase (ATP-hydrolyzing); SMART: DNA topoisomerase, type IIA, subunit A/C-terminal; SPTR: DNA gyrase, A subunit; TIGRFAM: DNA gyrase, subunit A; IMG reference gene:2503958187; PFAM: DNA gyrase/topoisomerase IV, subunit A; DNA gyrase C-terminal domain, beta-propeller; TIGRFAM: DNA gyrase, A subunit YP_004412446.1 COGs: COG0187 Type IIA topoisomerase (DNA gyrase/topo II topoisomerase IV) B subunit; InterProIPR003594:IPR013506:IPR006171:IPR002288:IPR 011557:IPR001241; KEGG: ssm:Spirs_4306 DNA gyrase, B subunit; PFAM: DNA topoisomerase, type IIA, subunit B, domain 2; ATPase-like, ATP-binding domain; Toprim domain; DNA topoisomerase, type IIA, subunit B, C-terminal; PRIAM: DNA topoisomerase (ATP-hydrolyzing); SMART: DNA topoisomerase, type IIA, subunit B/N-terminal; ATPase-like, ATP-binding domain; SPTR: DNA gyrase subunit B; TIGRFAM: DNA gyrase, subunit B; IMG reference gene:2503958188; PFAM: Toprim domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; DNA gyrase B; DNA gyrase B subunit, carboxyl terminus; TIGRFAM: DNA gyrase, B subunit