-- dump date   	20140620_032936
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
414684000001	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
414684000002	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
414684000003	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
414684000004	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
414684000005	active site
414684000006	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
414684000007	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
414684000008	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
414684000009	putative dimerization interface [polypeptide binding]; other site
414684000010	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318
414684000011	gating phenylalanine in ion channel; other site
414684000012	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
414684000013	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
414684000014	DNA binding residues [nucleotide binding]
414684000015	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
414684000016	Predicted membrane protein [Function unknown]; Region: COG4325
414684000017	Predicted membrane protein [Function unknown]; Region: COG2323
414684000018	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
414684000019	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
414684000020	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
414684000021	Walker A/P-loop; other site
414684000022	ATP binding site [chemical binding]; other site
414684000023	Q-loop/lid; other site
414684000024	ABC transporter signature motif; other site
414684000025	Walker B; other site
414684000026	D-loop; other site
414684000027	H-loop/switch region; other site
414684000028	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
414684000029	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
414684000030	Coenzyme A binding pocket [chemical binding]; other site
414684000031	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
414684000032	putative active site [active]
414684000033	putative metal binding site [ion binding]; other site
414684000034	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
414684000035	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
414684000036	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
414684000037	N-terminal plug; other site
414684000038	ligand-binding site [chemical binding]; other site
414684000039	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
414684000040	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
414684000041	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
414684000042	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
414684000043	GatB domain; Region: GatB_Yqey; smart00845
414684000044	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
414684000045	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
414684000046	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
414684000047	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
414684000048	catalytic residues [active]
414684000049	catalytic nucleophile [active]
414684000050	Recombinase; Region: Recombinase; pfam07508
414684000051	Protein of unknown function (DUF2924); Region: DUF2924; pfam11149
414684000052	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
414684000053	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
414684000054	non-specific DNA binding site [nucleotide binding]; other site
414684000055	salt bridge; other site
414684000056	sequence-specific DNA binding site [nucleotide binding]; other site
414684000057	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
414684000058	Domain of unknown function (DUF955); Region: DUF955; pfam06114
414684000059	Helix-turn-helix domain; Region: HTH_17; pfam12728
414684000060	AAA domain; Region: AAA_24; pfam13479
414684000061	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
414684000062	Walker A/P-loop; other site
414684000063	ATP binding site [chemical binding]; other site
414684000064	Q-loop/lid; other site
414684000065	ABC transporter signature motif; other site
414684000066	D-loop; other site
414684000067	AAA domain; Region: AAA_30; pfam13604
414684000068	Family description; Region: UvrD_C_2; pfam13538
414684000069	Toprim domain; Region: Toprim_3; pfam13362
414684000070	Virulence-associated protein E; Region: VirE; pfam05272
414684000071	vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556
414684000072	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
414684000073	ParB-like nuclease domain; Region: ParB; smart00470
414684000074	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
414684000075	DNA methylase; Region: N6_N4_Mtase; pfam01555
414684000076	ParB-like nuclease domain; Region: ParBc; pfam02195
414684000077	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
414684000078	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
414684000079	DNA methylase; Region: N6_N4_Mtase; pfam01555
414684000080	site-specific DNA methylase, pseudogene;Disrupted reading frame; identified by match to protein family HMM PF00145
414684000081	Protein of unknown function (DUF3489); Region: DUF3489; pfam11994
414684000082	Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720
414684000083	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
414684000084	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
414684000085	Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136
414684000086	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
414684000087	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
414684000088	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
414684000089	amidase catalytic site [active]
414684000090	Zn binding residues [ion binding]; other site
414684000091	substrate binding site [chemical binding]; other site
414684000092	Uncharacterized conserved protein (DUF2190); Region: DUF2190; pfam09956
414684000093	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
414684000094	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
414684000095	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
414684000096	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
414684000097	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
414684000098	Putative phage tail protein; Region: Phage-tail_3; pfam13550
414684000099	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
414684000100	Phage protein Gp37/Gp68; Region: Gp37_Gp68; pfam07505
414684000101	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
414684000102	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
414684000103	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
414684000104	Virulence protein [General function prediction only]; Region: COG3943
414684000105	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
414684000106	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
414684000107	DNA methylase; Region: N6_N4_Mtase; pfam01555
414684000108	DNA methylase; Region: N6_N4_Mtase; pfam01555
414684000109	AIPR protein; Region: AIPR; pfam10592
414684000110	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
414684000111	ATP binding site [chemical binding]; other site
414684000112	putative Mg++ binding site [ion binding]; other site
414684000113	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
414684000114	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
414684000115	nucleotide binding region [chemical binding]; other site
414684000116	ATP-binding site [chemical binding]; other site
414684000117	PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874
414684000118	putative active site [active]
414684000119	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
414684000120	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
414684000121	dimer interface [polypeptide binding]; other site
414684000122	putative functional site; other site
414684000123	putative MPT binding site; other site
414684000124	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
414684000125	trimer interface [polypeptide binding]; other site
414684000126	dimer interface [polypeptide binding]; other site
414684000127	putative active site [active]
414684000128	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
414684000129	active site
414684000130	ribulose/triose binding site [chemical binding]; other site
414684000131	phosphate binding site [ion binding]; other site
414684000132	substrate (anthranilate) binding pocket [chemical binding]; other site
414684000133	product (indole) binding pocket [chemical binding]; other site
414684000134	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
414684000135	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
414684000136	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
414684000137	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
414684000138	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
414684000139	glutamine binding [chemical binding]; other site
414684000140	catalytic triad [active]
414684000141	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
414684000142	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
414684000143	DNA binding residues [nucleotide binding]
414684000144	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
414684000145	NodB motif; other site
414684000146	putative active site [active]
414684000147	putative catalytic site [active]
414684000148	Zn binding site [ion binding]; other site
414684000149	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
414684000150	metal-binding site [ion binding]
414684000151	anthranilate synthase component I; Provisional; Region: PRK13573
414684000152	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
414684000153	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
414684000154	SurA N-terminal domain; Region: SurA_N_3; cl07813
414684000155	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
414684000156	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
414684000157	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
414684000158	triosephosphate isomerase; Provisional; Region: PRK14565
414684000159	substrate binding site [chemical binding]; other site
414684000160	dimer interface [polypeptide binding]; other site
414684000161	catalytic triad [active]
414684000162	Preprotein translocase SecG subunit; Region: SecG; pfam03840
414684000163	CTP synthetase; Validated; Region: pyrG; PRK05380
414684000164	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
414684000165	Catalytic site [active]
414684000166	active site
414684000167	UTP binding site [chemical binding]; other site
414684000168	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
414684000169	active site
414684000170	putative oxyanion hole; other site
414684000171	catalytic triad [active]
414684000172	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
414684000173	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
414684000174	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
414684000175	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
414684000176	putative acyl-acceptor binding pocket; other site
414684000177	enolase; Provisional; Region: eno; PRK00077
414684000178	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
414684000179	dimer interface [polypeptide binding]; other site
414684000180	metal binding site [ion binding]; metal-binding site
414684000181	substrate binding pocket [chemical binding]; other site
414684000182	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
414684000183	Septum formation initiator; Region: DivIC; pfam04977
414684000184	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
414684000185	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
414684000186	tetramer interface [polypeptide binding]; other site
414684000187	TPP-binding site [chemical binding]; other site
414684000188	heterodimer interface [polypeptide binding]; other site
414684000189	phosphorylation loop region [posttranslational modification]
414684000190	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
414684000191	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
414684000192	E3 interaction surface; other site
414684000193	lipoyl attachment site [posttranslational modification]; other site
414684000194	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
414684000195	alpha subunit interface [polypeptide binding]; other site
414684000196	TPP binding site [chemical binding]; other site
414684000197	heterodimer interface [polypeptide binding]; other site
414684000198	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
414684000199	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
414684000200	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
414684000201	E3 interaction surface; other site
414684000202	lipoyl attachment site [posttranslational modification]; other site
414684000203	e3 binding domain; Region: E3_binding; pfam02817
414684000204	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
414684000205	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
414684000206	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
414684000207	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
414684000208	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
414684000209	lipoyl synthase; Provisional; Region: PRK05481
414684000210	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
414684000211	putative coenzyme Q binding site [chemical binding]; other site
414684000212	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
414684000213	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
414684000214	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
414684000215	substrate binding site; other site
414684000216	dimer interface; other site
414684000217	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
414684000218	homotrimer interaction site [polypeptide binding]; other site
414684000219	zinc binding site [ion binding]; other site
414684000220	CDP-binding sites; other site
414684000221	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
414684000222	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
414684000223	FMN binding site [chemical binding]; other site
414684000224	active site
414684000225	catalytic residues [active]
414684000226	substrate binding site [chemical binding]; other site
414684000227	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
414684000228	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684000229	putative active site [active]
414684000230	heme pocket [chemical binding]; other site
414684000231	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684000232	dimer interface [polypeptide binding]; other site
414684000233	phosphorylation site [posttranslational modification]
414684000234	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684000235	ATP binding site [chemical binding]; other site
414684000236	Mg2+ binding site [ion binding]; other site
414684000237	G-X-G motif; other site
414684000238	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
414684000239	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684000240	active site
414684000241	phosphorylation site [posttranslational modification]
414684000242	intermolecular recognition site; other site
414684000243	dimerization interface [polypeptide binding]; other site
414684000244	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
414684000245	Walker A motif; other site
414684000246	ATP binding site [chemical binding]; other site
414684000247	Walker B motif; other site
414684000248	arginine finger; other site
414684000249	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
414684000250	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
414684000251	dimerization interface [polypeptide binding]; other site
414684000252	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
414684000253	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684000254	dimer interface [polypeptide binding]; other site
414684000255	phosphorylation site [posttranslational modification]
414684000256	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684000257	ATP binding site [chemical binding]; other site
414684000258	Mg2+ binding site [ion binding]; other site
414684000259	G-X-G motif; other site
414684000260	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
414684000261	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684000262	active site
414684000263	phosphorylation site [posttranslational modification]
414684000264	intermolecular recognition site; other site
414684000265	dimerization interface [polypeptide binding]; other site
414684000266	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
414684000267	Walker A motif; other site
414684000268	ATP binding site [chemical binding]; other site
414684000269	Walker B motif; other site
414684000270	arginine finger; other site
414684000271	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
414684000272	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
414684000273	TrkA-N domain; Region: TrkA_N; pfam02254
414684000274	TrkA-C domain; Region: TrkA_C; pfam02080
414684000275	TrkA-N domain; Region: TrkA_N; pfam02254
414684000276	TrkA-C domain; Region: TrkA_C; pfam02080
414684000277	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
414684000278	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
414684000279	homodimer interface [polypeptide binding]; other site
414684000280	substrate-cofactor binding pocket; other site
414684000281	pyridoxal 5'-phosphate binding site [chemical binding]; other site
414684000282	catalytic residue [active]
414684000283	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
414684000284	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
414684000285	motif II; other site
414684000286	bacterial Hfq-like; Region: Hfq; cd01716
414684000287	hexamer interface [polypeptide binding]; other site
414684000288	Sm1 motif; other site
414684000289	RNA binding site [nucleotide binding]; other site
414684000290	Sm2 motif; other site
414684000291	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
414684000292	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
414684000293	HflX GTPase family; Region: HflX; cd01878
414684000294	G1 box; other site
414684000295	GTP/Mg2+ binding site [chemical binding]; other site
414684000296	Switch I region; other site
414684000297	G2 box; other site
414684000298	G3 box; other site
414684000299	Switch II region; other site
414684000300	G4 box; other site
414684000301	G5 box; other site
414684000302	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
414684000303	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
414684000304	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
414684000305	putative active site [active]
414684000306	putative substrate binding site [chemical binding]; other site
414684000307	putative cosubstrate binding site; other site
414684000308	catalytic site [active]
414684000309	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
414684000310	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
414684000311	active site
414684000312	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
414684000313	NAD(P) binding site [chemical binding]; other site
414684000314	malonic semialdehyde reductase; Provisional; Region: PRK10538
414684000315	active site
414684000316	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
414684000317	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
414684000318	homodimer interface [polypeptide binding]; other site
414684000319	metal binding site [ion binding]; metal-binding site
414684000320	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
414684000321	homodimer interface [polypeptide binding]; other site
414684000322	active site
414684000323	putative chemical substrate binding site [chemical binding]; other site
414684000324	metal binding site [ion binding]; metal-binding site
414684000325	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
414684000326	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
414684000327	DNA binding residues [nucleotide binding]
414684000328	dimer interface [polypeptide binding]; other site
414684000329	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
414684000330	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
414684000331	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
414684000332	FAD binding site [chemical binding]; other site
414684000333	substrate binding pocket [chemical binding]; other site
414684000334	catalytic base [active]
414684000335	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
414684000336	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
414684000337	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
414684000338	MarR family; Region: MarR_2; pfam12802
414684000339	Uncharacterized conserved protein [Function unknown]; Region: COG0393
414684000340	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
414684000341	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
414684000342	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
414684000343	AMP-binding enzyme; Region: AMP-binding; pfam00501
414684000344	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
414684000345	active site
414684000346	CoA binding site [chemical binding]; other site
414684000347	AMP binding site [chemical binding]; other site
414684000348	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807
414684000349	putative active site [active]
414684000350	YdjC motif; other site
414684000351	Mg binding site [ion binding]; other site
414684000352	putative homodimer interface [polypeptide binding]; other site
414684000353	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
414684000354	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
414684000355	Ligand binding site; other site
414684000356	Putative Catalytic site; other site
414684000357	DXD motif; other site
414684000358	exopolyphosphatase; Region: exo_poly_only; TIGR03706
414684000359	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
414684000360	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
414684000361	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684000362	S-adenosylmethionine binding site [chemical binding]; other site
414684000363	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
414684000364	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
414684000365	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
414684000366	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
414684000367	active site
414684000368	16S rRNA methyltransferase B; Provisional; Region: PRK14902
414684000369	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684000370	S-adenosylmethionine binding site [chemical binding]; other site
414684000371	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
414684000372	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
414684000373	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
414684000374	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
414684000375	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
414684000376	Amidase; Region: Amidase; cl11426
414684000377	Spore Coat Protein U domain; Region: SCPU; pfam05229
414684000378	Spore Coat Protein U domain; Region: SCPU; pfam05229
414684000379	Response regulator receiver domain; Region: Response_reg; pfam00072
414684000380	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684000381	active site
414684000382	phosphorylation site [posttranslational modification]
414684000383	intermolecular recognition site; other site
414684000384	dimerization interface [polypeptide binding]; other site
414684000385	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
414684000386	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
414684000387	Walker A motif; other site
414684000388	ATP binding site [chemical binding]; other site
414684000389	Walker B motif; other site
414684000390	arginine finger; other site
414684000391	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
414684000392	ParA-like protein; Provisional; Region: PHA02518
414684000393	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
414684000394	P-loop; other site
414684000395	Magnesium ion binding site [ion binding]; other site
414684000396	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
414684000397	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
414684000398	putative ADP-binding pocket [chemical binding]; other site
414684000399	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
414684000400	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
414684000401	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
414684000402	Substrate binding site; other site
414684000403	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
414684000404	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
414684000405	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
414684000406	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
414684000407	FliG C-terminal domain; Region: FliG_C; pfam01706
414684000408	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
414684000409	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
414684000410	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
414684000411	flagellar assembly protein H; Validated; Region: fliH; PRK06032
414684000412	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
414684000413	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
414684000414	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
414684000415	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
414684000416	flagellar motor switch protein FliM; Reviewed; Region: fliM; PRK12795
414684000417	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
414684000418	Uncharacterized conserved protein [Function unknown]; Region: COG3334
414684000419	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
414684000420	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
414684000421	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
414684000422	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
414684000423	FHIPEP family; Region: FHIPEP; pfam00771
414684000424	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
414684000425	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
414684000426	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790
414684000427	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782
414684000428	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
414684000429	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
414684000430	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004
414684000431	flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927
414684000432	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
414684000433	Walker A motif/ATP binding site; other site
414684000434	Walker B motif; other site
414684000435	Phosphate transporter family; Region: PHO4; pfam01384
414684000436	Phosphate transporter family; Region: PHO4; pfam01384
414684000437	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
414684000438	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
414684000439	Flagellar protein FlbT; Region: FlbT; pfam07378
414684000440	Flagellar protein FlaF; Region: FlaF; pfam07309
414684000441	flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793
414684000442	flagellin; Reviewed; Region: PRK12687
414684000443	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
414684000444	Rod binding protein; Region: Rod-binding; pfam10135
414684000445	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
414684000446	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
414684000447	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
414684000448	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684000449	active site
414684000450	phosphorylation site [posttranslational modification]
414684000451	intermolecular recognition site; other site
414684000452	dimerization interface [polypeptide binding]; other site
414684000453	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
414684000454	DNA binding site [nucleotide binding]
414684000455	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008
414684000456	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
414684000457	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
414684000458	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521
414684000459	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
414684000460	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
414684000461	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
414684000462	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
414684000463	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
414684000464	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
414684000465	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
414684000466	ligand binding site [chemical binding]; other site
414684000467	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
414684000468	flagellar motor protein MotA; Validated; Region: PRK09110
414684000469	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642
414684000470	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
414684000471	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691
414684000472	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
414684000473	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
414684000474	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
414684000475	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
414684000476	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12788
414684000477	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
414684000478	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
414684000479	non-specific DNA binding site [nucleotide binding]; other site
414684000480	salt bridge; other site
414684000481	sequence-specific DNA binding site [nucleotide binding]; other site
414684000482	Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843
414684000483	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
414684000484	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
414684000485	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
414684000486	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
414684000487	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
414684000488	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
414684000489	aldolase II superfamily protein; Provisional; Region: PRK07044
414684000490	intersubunit interface [polypeptide binding]; other site
414684000491	active site
414684000492	Zn2+ binding site [ion binding]; other site
414684000493	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
414684000494	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
414684000495	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
414684000496	active site
414684000497	catalytic site [active]
414684000498	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
414684000499	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
414684000500	active site
414684000501	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551
414684000502	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
414684000503	putative acyl-acceptor binding pocket; other site
414684000504	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
414684000505	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
414684000506	NAD(P) binding site [chemical binding]; other site
414684000507	active site
414684000508	Methyltransferase domain; Region: Methyltransf_31; pfam13847
414684000509	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684000510	S-adenosylmethionine binding site [chemical binding]; other site
414684000511	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
414684000512	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
414684000513	PYR/PP interface [polypeptide binding]; other site
414684000514	dimer interface [polypeptide binding]; other site
414684000515	TPP binding site [chemical binding]; other site
414684000516	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
414684000517	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
414684000518	TPP-binding site [chemical binding]; other site
414684000519	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
414684000520	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
414684000521	Phosphotransferase enzyme family; Region: APH; pfam01636
414684000522	active site
414684000523	ATP binding site [chemical binding]; other site
414684000524	antibiotic binding site [chemical binding]; other site
414684000525	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
414684000526	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
414684000527	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
414684000528	putative dimerization interface [polypeptide binding]; other site
414684000529	ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208
414684000530	Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232
414684000531	dimer interface [polypeptide binding]; other site
414684000532	catalytic residue [active]
414684000533	metal binding site [ion binding]; metal-binding site
414684000534	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
414684000535	multimerization interface [polypeptide binding]; other site
414684000536	gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640
414684000537	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
414684000538	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
414684000539	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
414684000540	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
414684000541	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
414684000542	PhoD-like phosphatase; Region: PhoD; pfam09423
414684000543	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
414684000544	putative active site [active]
414684000545	putative metal binding site [ion binding]; other site
414684000546	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
414684000547	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
414684000548	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
414684000549	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
414684000550	ligand binding site [chemical binding]; other site
414684000551	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
414684000552	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
414684000553	Walker A/P-loop; other site
414684000554	ATP binding site [chemical binding]; other site
414684000555	Q-loop/lid; other site
414684000556	ABC transporter signature motif; other site
414684000557	Walker B; other site
414684000558	D-loop; other site
414684000559	H-loop/switch region; other site
414684000560	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
414684000561	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
414684000562	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
414684000563	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
414684000564	TM-ABC transporter signature motif; other site
414684000565	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
414684000566	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
414684000567	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
414684000568	TM-ABC transporter signature motif; other site
414684000569	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
414684000570	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
414684000571	active site
414684000572	metal binding site [ion binding]; metal-binding site
414684000573	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
414684000574	Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613
414684000575	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
414684000576	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
414684000577	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
414684000578	Ligand Binding Site [chemical binding]; other site
414684000579	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
414684000580	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
414684000581	Coenzyme A binding pocket [chemical binding]; other site
414684000582	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
414684000583	CoenzymeA binding site [chemical binding]; other site
414684000584	subunit interaction site [polypeptide binding]; other site
414684000585	PHB binding site; other site
414684000586	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
414684000587	putative active site [active]
414684000588	putative catalytic site [active]
414684000589	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
414684000590	RNA polymerase sigma factor; Provisional; Region: PRK12511
414684000591	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
414684000592	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
414684000593	DNA binding residues [nucleotide binding]
414684000594	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
414684000595	alanyl-tRNA synthetase; Provisional; Region: alaS; PRK13902
414684000596	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
414684000597	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
414684000598	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
414684000599	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
414684000600	N- and C-terminal domain interface [polypeptide binding]; other site
414684000601	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
414684000602	active site
414684000603	MgATP binding site [chemical binding]; other site
414684000604	catalytic site [active]
414684000605	metal binding site [ion binding]; metal-binding site
414684000606	glycerol binding site [chemical binding]; other site
414684000607	homotetramer interface [polypeptide binding]; other site
414684000608	homodimer interface [polypeptide binding]; other site
414684000609	FBP binding site [chemical binding]; other site
414684000610	protein IIAGlc interface [polypeptide binding]; other site
414684000611	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
414684000612	ACT domain; Region: ACT_6; pfam13740
414684000613	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869
414684000614	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
414684000615	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
414684000616	substrate binding site [chemical binding]; other site
414684000617	catalytic Zn binding site [ion binding]; other site
414684000618	NAD binding site [chemical binding]; other site
414684000619	structural Zn binding site [ion binding]; other site
414684000620	dimer interface [polypeptide binding]; other site
414684000621	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
414684000622	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684000623	dimer interface [polypeptide binding]; other site
414684000624	phosphorylation site [posttranslational modification]
414684000625	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684000626	ATP binding site [chemical binding]; other site
414684000627	G-X-G motif; other site
414684000628	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
414684000629	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
414684000630	WHG domain; Region: WHG; pfam13305
414684000631	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
414684000632	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
414684000633	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
414684000634	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
414684000635	Protein export membrane protein; Region: SecD_SecF; cl14618
414684000636	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
414684000637	Zn binding site [ion binding]; other site
414684000638	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
414684000639	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
414684000640	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
414684000641	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
414684000642	N-terminal plug; other site
414684000643	ligand-binding site [chemical binding]; other site
414684000644	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
414684000645	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
414684000646	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
414684000647	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
414684000648	multidrug efflux protein; Reviewed; Region: PRK09579
414684000649	V4R domain; Region: V4R; cl15268
414684000650	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
414684000651	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026
414684000652	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
414684000653	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
414684000654	FeS/SAM binding site; other site
414684000655	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
414684000656	Esterase PHB depolymerase; Region: Esterase_phd; pfam10503
414684000657	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
414684000658	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
414684000659	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
414684000660	Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451
414684000661	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
414684000662	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
414684000663	putative active site [active]
414684000664	catalytic site [active]
414684000665	putative metal binding site [ion binding]; other site
414684000666	PhoD-like phosphatase; Region: PhoD; pfam09423
414684000667	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
414684000668	putative active site [active]
414684000669	putative metal binding site [ion binding]; other site
414684000670	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
414684000671	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
414684000672	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
414684000673	N-terminal plug; other site
414684000674	ligand-binding site [chemical binding]; other site
414684000675	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
414684000676	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
414684000677	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
414684000678	Phytase; Region: Phytase; cl17685
414684000679	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
414684000680	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
414684000681	dimerization interface [polypeptide binding]; other site
414684000682	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
414684000683	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684000684	dimer interface [polypeptide binding]; other site
414684000685	putative CheW interface [polypeptide binding]; other site
414684000686	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
414684000687	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
414684000688	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684000689	dimer interface [polypeptide binding]; other site
414684000690	putative CheW interface [polypeptide binding]; other site
414684000691	Predicted integral membrane protein [Function unknown]; Region: COG0392
414684000692	Uncharacterized conserved protein [Function unknown]; Region: COG2898
414684000693	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
414684000694	Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946
414684000695	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
414684000696	plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647
414684000697	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
414684000698	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
414684000699	Soluble P-type ATPase [General function prediction only]; Region: COG4087
414684000700	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
414684000701	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
414684000702	Zn2+ binding site [ion binding]; other site
414684000703	Mg2+ binding site [ion binding]; other site
414684000704	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
414684000705	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
414684000706	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
414684000707	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
414684000708	Walker A/P-loop; other site
414684000709	ATP binding site [chemical binding]; other site
414684000710	Q-loop/lid; other site
414684000711	ABC transporter signature motif; other site
414684000712	Walker B; other site
414684000713	D-loop; other site
414684000714	H-loop/switch region; other site
414684000715	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
414684000716	Walker A/P-loop; other site
414684000717	ATP binding site [chemical binding]; other site
414684000718	Q-loop/lid; other site
414684000719	ABC transporter signature motif; other site
414684000720	Walker B; other site
414684000721	D-loop; other site
414684000722	H-loop/switch region; other site
414684000723	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
414684000724	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
414684000725	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
414684000726	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
414684000727	HlyD family secretion protein; Region: HlyD_3; pfam13437
414684000728	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
414684000729	Protein of unknown function (DUF2877); Region: DUF2877; pfam11392
414684000730	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
414684000731	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
414684000732	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
414684000733	N-terminal plug; other site
414684000734	ligand-binding site [chemical binding]; other site
414684000735	conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806
414684000736	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
414684000737	parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805
414684000738	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
414684000739	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
414684000740	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
414684000741	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
414684000742	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
414684000743	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
414684000744	active site
414684000745	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
414684000746	catalytic tetrad [active]
414684000747	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
414684000748	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
414684000749	intersubunit interface [polypeptide binding]; other site
414684000750	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
414684000751	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
414684000752	ABC-ATPase subunit  interface; other site
414684000753	dimer interface [polypeptide binding]; other site
414684000754	putative PBP binding regions; other site
414684000755	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
414684000756	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
414684000757	Walker A/P-loop; other site
414684000758	ATP binding site [chemical binding]; other site
414684000759	Q-loop/lid; other site
414684000760	ABC transporter signature motif; other site
414684000761	Walker B; other site
414684000762	D-loop; other site
414684000763	H-loop/switch region; other site
414684000764	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
414684000765	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
414684000766	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
414684000767	FeS/SAM binding site; other site
414684000768	pseudogene;identified by match to protein family HMM PF00005
414684000769	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
414684000770	ATP cone domain; Region: ATP-cone; pfam03477
414684000771	Class III ribonucleotide reductase; Region: RNR_III; cd01675
414684000772	effector binding site; other site
414684000773	active site
414684000774	Zn binding site [ion binding]; other site
414684000775	glycine loop; other site
414684000776	cobyric acid synthase; Provisional; Region: PRK00784
414684000777	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
414684000778	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
414684000779	catalytic triad [active]
414684000780	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
414684000781	Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; pfam02283
414684000782	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
414684000783	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
414684000784	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
414684000785	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
414684000786	catalytic residue [active]
414684000787	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
414684000788	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
414684000789	N-terminal plug; other site
414684000790	ligand-binding site [chemical binding]; other site
414684000791	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684000792	PAS fold; Region: PAS_3; pfam08447
414684000793	putative active site [active]
414684000794	heme pocket [chemical binding]; other site
414684000795	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684000796	PAS domain; Region: PAS_9; pfam13426
414684000797	putative active site [active]
414684000798	heme pocket [chemical binding]; other site
414684000799	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684000800	dimer interface [polypeptide binding]; other site
414684000801	putative CheW interface [polypeptide binding]; other site
414684000802	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
414684000803	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
414684000804	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
414684000805	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
414684000806	outer membrane receptor FepA; Provisional; Region: PRK13528
414684000807	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
414684000808	N-terminal plug; other site
414684000809	ligand-binding site [chemical binding]; other site
414684000810	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684000811	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
414684000812	putative active site [active]
414684000813	heme pocket [chemical binding]; other site
414684000814	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684000815	PAS fold; Region: PAS_3; pfam08447
414684000816	putative active site [active]
414684000817	heme pocket [chemical binding]; other site
414684000818	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
414684000819	HWE histidine kinase; Region: HWE_HK; smart00911
414684000820	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
414684000821	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684000822	active site
414684000823	phosphorylation site [posttranslational modification]
414684000824	intermolecular recognition site; other site
414684000825	dimerization interface [polypeptide binding]; other site
414684000826	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
414684000827	putative binding surface; other site
414684000828	active site
414684000829	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
414684000830	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
414684000831	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684000832	ATP binding site [chemical binding]; other site
414684000833	Mg2+ binding site [ion binding]; other site
414684000834	G-X-G motif; other site
414684000835	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
414684000836	Response regulator receiver domain; Region: Response_reg; pfam00072
414684000837	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684000838	active site
414684000839	phosphorylation site [posttranslational modification]
414684000840	intermolecular recognition site; other site
414684000841	dimerization interface [polypeptide binding]; other site
414684000842	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
414684000843	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
414684000844	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
414684000845	HEAT repeats; Region: HEAT_2; pfam13646
414684000846	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
414684000847	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684000848	active site
414684000849	phosphorylation site [posttranslational modification]
414684000850	intermolecular recognition site; other site
414684000851	dimerization interface [polypeptide binding]; other site
414684000852	CheB methylesterase; Region: CheB_methylest; pfam01339
414684000853	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
414684000854	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
414684000855	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
414684000856	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684000857	dimer interface [polypeptide binding]; other site
414684000858	putative CheW interface [polypeptide binding]; other site
414684000859	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684000860	dimer interface [polypeptide binding]; other site
414684000861	putative CheW interface [polypeptide binding]; other site
414684000862	PAS fold; Region: PAS; pfam00989
414684000863	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684000864	putative active site [active]
414684000865	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
414684000866	dimer interface [polypeptide binding]; other site
414684000867	phosphorylation site [posttranslational modification]
414684000868	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684000869	phosphorylation site [posttranslational modification]
414684000870	intermolecular recognition site; other site
414684000871	serine;Alternate names identified by match to protein family HMM PF01584
414684000872	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
414684000873	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
414684000874	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
414684000875	Response regulator receiver domain; Region: Response_reg; pfam00072
414684000876	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684000877	active site
414684000878	phosphorylation site [posttranslational modification]
414684000879	intermolecular recognition site; other site
414684000880	dimerization interface [polypeptide binding]; other site
414684000881	PAS domain; Region: PAS_9; pfam13426
414684000882	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684000883	putative active site [active]
414684000884	heme pocket [chemical binding]; other site
414684000885	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684000886	dimer interface [polypeptide binding]; other site
414684000887	phosphorylation site [posttranslational modification]
414684000888	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684000889	ATP binding site [chemical binding]; other site
414684000890	G-X-G motif; other site
414684000891	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
414684000892	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684000893	active site
414684000894	phosphorylation site [posttranslational modification]
414684000895	intermolecular recognition site; other site
414684000896	dimerization interface [polypeptide binding]; other site
414684000897	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
414684000898	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684000899	dimer interface [polypeptide binding]; other site
414684000900	putative CheW interface [polypeptide binding]; other site
414684000901	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
414684000902	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684000903	active site
414684000904	phosphorylation site [posttranslational modification]
414684000905	intermolecular recognition site; other site
414684000906	dimerization interface [polypeptide binding]; other site
414684000907	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
414684000908	dimerization interface [polypeptide binding]; other site
414684000909	DNA binding residues [nucleotide binding]
414684000910	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
414684000911	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
414684000912	Probable Catalytic site; other site
414684000913	metal-binding site
414684000914	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
414684000915	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
414684000916	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
414684000917	Walker A/P-loop; other site
414684000918	ATP binding site [chemical binding]; other site
414684000919	Q-loop/lid; other site
414684000920	ABC transporter signature motif; other site
414684000921	Walker B; other site
414684000922	D-loop; other site
414684000923	H-loop/switch region; other site
414684000924	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
414684000925	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
414684000926	HlyD family secretion protein; Region: HlyD_3; pfam13437
414684000927	SapC; Region: SapC; pfam07277
414684000928	F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597
414684000929	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
414684000930	alpha subunit interaction interface [polypeptide binding]; other site
414684000931	Walker A motif; other site
414684000932	ATP binding site [chemical binding]; other site
414684000933	Walker B motif; other site
414684000934	inhibitor binding site; inhibition site
414684000935	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
414684000936	F0F1 ATP synthase subunit epsilon; Provisional; Region: PRK13447
414684000937	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
414684000938	gamma subunit interface [polypeptide binding]; other site
414684000939	epsilon subunit interface [polypeptide binding]; other site
414684000940	LBP interface [polypeptide binding]; other site
414684000941	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
414684000942	F0F1 ATP synthase subunit A; Provisional; Region: PRK13421
414684000943	F0F1 ATP synthase subunit C; Provisional; Region: PRK13468
414684000944	alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321
414684000945	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
414684000946	type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546
414684000947	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
414684000948	Walker A motif; other site
414684000949	ATP binding site [chemical binding]; other site
414684000950	Walker B motif; other site
414684000951	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
414684000952	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cl00365
414684000953	core domain interface [polypeptide binding]; other site
414684000954	delta subunit interface [polypeptide binding]; other site
414684000955	epsilon subunit interface [polypeptide binding]; other site
414684000956	Protein of unknown function (DUF1489); Region: DUF1489; pfam07370
414684000957	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
414684000958	active site
414684000959	catalytic residues [active]
414684000960	metal binding site [ion binding]; metal-binding site
414684000961	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
414684000962	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
414684000963	active site
414684000964	Predicted membrane protein [Function unknown]; Region: COG1238
414684000965	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
414684000966	dimerization interface [polypeptide binding]; other site
414684000967	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
414684000968	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684000969	dimer interface [polypeptide binding]; other site
414684000970	putative CheW interface [polypeptide binding]; other site
414684000971	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
414684000972	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
414684000973	ATP-grasp domain; Region: ATP-grasp_4; cl17255
414684000974	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
414684000975	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
414684000976	carboxyltransferase (CT) interaction site; other site
414684000977	biotinylation site [posttranslational modification]; other site
414684000978	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
414684000979	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
414684000980	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
414684000981	TrkA-N domain; Region: TrkA_N; pfam02254
414684000982	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
414684000983	dimerization interface [polypeptide binding]; other site
414684000984	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684000985	dimer interface [polypeptide binding]; other site
414684000986	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
414684000987	putative CheW interface [polypeptide binding]; other site
414684000988	Ion channel; Region: Ion_trans_2; pfam07885
414684000989	enoyl-CoA hydratase; Provisional; Region: PRK05995
414684000990	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
414684000991	substrate binding site [chemical binding]; other site
414684000992	oxyanion hole (OAH) forming residues; other site
414684000993	trimer interface [polypeptide binding]; other site
414684000994	flagellin; Reviewed; Region: PRK08869
414684000995	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
414684000996	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
414684000997	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
414684000998	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
414684000999	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
414684001000	structural tetrad; other site
414684001001	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
414684001002	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
414684001003	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
414684001004	Fatty acid desaturase; Region: FA_desaturase; pfam00487
414684001005	Di-iron ligands [ion binding]; other site
414684001006	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
414684001007	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
414684001008	putative catalytic residue [active]
414684001009	C factor cell-cell signaling protein; Provisional; Region: PRK09009
414684001010	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
414684001011	NADP binding site [chemical binding]; other site
414684001012	homodimer interface [polypeptide binding]; other site
414684001013	active site
414684001014	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
414684001015	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cd00598
414684001016	active site
414684001017	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
414684001018	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
414684001019	dimer interface [polypeptide binding]; other site
414684001020	active site
414684001021	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
414684001022	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
414684001023	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
414684001024	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
414684001025	ligand binding site [chemical binding]; other site
414684001026	flexible hinge region; other site
414684001027	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
414684001028	isovaleryl-CoA dehydrogenase; Region: PLN02519
414684001029	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
414684001030	substrate binding site [chemical binding]; other site
414684001031	FAD binding site [chemical binding]; other site
414684001032	catalytic base [active]
414684001033	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
414684001034	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
414684001035	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
414684001036	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
414684001037	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
414684001038	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
414684001039	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
414684001040	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
414684001041	MgtE intracellular N domain; Region: MgtE_N; smart00924
414684001042	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
414684001043	Divalent cation transporter; Region: MgtE; pfam01769
414684001044	malic enzyme; Reviewed; Region: PRK12862
414684001045	Malic enzyme, N-terminal domain; Region: malic; pfam00390
414684001046	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
414684001047	putative NAD(P) binding site [chemical binding]; other site
414684001048	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
414684001049	lipoate-protein ligase B; Provisional; Region: PRK14341
414684001050	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
414684001051	dinuclear metal binding motif [ion binding]; other site
414684001052	Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254
414684001053	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
414684001054	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
414684001055	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
414684001056	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
414684001057	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
414684001058	carboxyltransferase (CT) interaction site; other site
414684001059	biotinylation site [posttranslational modification]; other site
414684001060	Flagellin N-methylase; Region: FliB; cl00497
414684001061	2TM domain; Region: 2TM; pfam13239
414684001062	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
414684001063	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
414684001064	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
414684001065	SCP-2 sterol transfer family; Region: SCP2; pfam02036
414684001066	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
414684001067	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
414684001068	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
414684001069	ATP12 chaperone protein; Region: ATP12; pfam07542
414684001070	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
414684001071	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
414684001072	motif II; other site
414684001073	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
414684001074	S4 RNA-binding domain; Region: S4; smart00363
414684001075	RNA binding surface [nucleotide binding]; other site
414684001076	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
414684001077	active site
414684001078	camphor resistance protein CrcB; Provisional; Region: PRK14195
414684001079	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
414684001080	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
414684001081	recombination factor protein RarA; Reviewed; Region: PRK13342
414684001082	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
414684001083	Walker A motif; other site
414684001084	ATP binding site [chemical binding]; other site
414684001085	Walker B motif; other site
414684001086	arginine finger; other site
414684001087	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
414684001088	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
414684001089	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
414684001090	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
414684001091	protein binding site [polypeptide binding]; other site
414684001092	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
414684001093	protein binding site [polypeptide binding]; other site
414684001094	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
414684001095	aspartate racemase; Region: asp_race; TIGR00035
414684001096	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
414684001097	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684001098	active site
414684001099	phosphorylation site [posttranslational modification]
414684001100	intermolecular recognition site; other site
414684001101	dimerization interface [polypeptide binding]; other site
414684001102	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
414684001103	DNA binding site [nucleotide binding]
414684001104	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
414684001105	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
414684001106	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
414684001107	Ligand Binding Site [chemical binding]; other site
414684001108	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
414684001109	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684001110	dimer interface [polypeptide binding]; other site
414684001111	phosphorylation site [posttranslational modification]
414684001112	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684001113	ATP binding site [chemical binding]; other site
414684001114	Mg2+ binding site [ion binding]; other site
414684001115	G-X-G motif; other site
414684001116	K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156
414684001117	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
414684001118	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
414684001119	Soluble P-type ATPase [General function prediction only]; Region: COG4087
414684001120	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
414684001121	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
414684001122	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
414684001123	dimerization interface [polypeptide binding]; other site
414684001124	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
414684001125	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
414684001126	dimer interface [polypeptide binding]; other site
414684001127	decamer (pentamer of dimers) interface [polypeptide binding]; other site
414684001128	catalytic triad [active]
414684001129	peroxidatic and resolving cysteines [active]
414684001130	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
414684001131	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
414684001132	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
414684001133	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
414684001134	putative DNA binding site [nucleotide binding]; other site
414684001135	putative Zn2+ binding site [ion binding]; other site
414684001136	AsnC family; Region: AsnC_trans_reg; pfam01037
414684001137	gamma-glutamyl kinase; Provisional; Region: PRK05429
414684001138	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
414684001139	nucleotide binding site [chemical binding]; other site
414684001140	homotetrameric interface [polypeptide binding]; other site
414684001141	putative phosphate binding site [ion binding]; other site
414684001142	putative allosteric binding site; other site
414684001143	PUA domain; Region: PUA; pfam01472
414684001144	GTPase CgtA; Reviewed; Region: obgE; PRK12299
414684001145	GTP1/OBG; Region: GTP1_OBG; pfam01018
414684001146	Obg GTPase; Region: Obg; cd01898
414684001147	G1 box; other site
414684001148	GTP/Mg2+ binding site [chemical binding]; other site
414684001149	Switch I region; other site
414684001150	G2 box; other site
414684001151	G3 box; other site
414684001152	Switch II region; other site
414684001153	G4 box; other site
414684001154	G5 box; other site
414684001155	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
414684001156	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
414684001157	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
414684001158	AAA domain; Region: AAA_27; pfam13514
414684001159	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
414684001160	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
414684001161	active site
414684001162	metal binding site [ion binding]; metal-binding site
414684001163	DNA binding site [nucleotide binding]
414684001164	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
414684001165	active site
414684001166	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
414684001167	Periplasmic nitrate reductase protein NapE; Region: NapE; pfam06796
414684001168	ferredoxin-type protein; Provisional; Region: PRK10194
414684001169	NapD protein; Region: NapD; pfam03927
414684001170	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
414684001171	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
414684001172	[4Fe-4S] binding site [ion binding]; other site
414684001173	molybdopterin cofactor binding site; other site
414684001174	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
414684001175	molybdopterin cofactor binding site; other site
414684001176	Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892
414684001177	Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005
414684001178	periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161
414684001179	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
414684001180	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
414684001181	active site
414684001182	copper-transporting P-type ATPase;identified by match to protein family HMM PF03927
414684001183	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
414684001184	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
414684001185	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012
414684001186	SEC-C motif; Region: SEC-C; pfam02810
414684001187	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
414684001188	Flavodoxin; Region: Flavodoxin_1; pfam00258
414684001189	ferredoxin--NADP+ reductase; Provisional; Region: PLN03116
414684001190	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
414684001191	FAD binding pocket [chemical binding]; other site
414684001192	conserved FAD binding motif [chemical binding]; other site
414684001193	phosphate binding motif [ion binding]; other site
414684001194	beta-alpha-beta structure motif; other site
414684001195	NAD binding pocket [chemical binding]; other site
414684001196	Dihaem cytochrome c; Region: DHC; pfam09626
414684001197	Domain of unknown function (DUF1924); Region: DUF1924; pfam09086
414684001198	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
414684001199	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
414684001200	Predicted membrane protein [Function unknown]; Region: COG3212
414684001201	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
414684001202	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
414684001203	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684001204	active site
414684001205	phosphorylation site [posttranslational modification]
414684001206	intermolecular recognition site; other site
414684001207	dimerization interface [polypeptide binding]; other site
414684001208	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
414684001209	DNA binding site [nucleotide binding]
414684001210	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
414684001211	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684001212	ATP binding site [chemical binding]; other site
414684001213	Mg2+ binding site [ion binding]; other site
414684001214	G-X-G motif; other site
414684001215	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
414684001216	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
414684001217	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684001218	dimer interface [polypeptide binding]; other site
414684001219	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
414684001220	putative CheW interface [polypeptide binding]; other site
414684001221	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
414684001222	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
414684001223	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
414684001224	catalytic residue [active]
414684001225	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
414684001226	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
414684001227	trimerization site [polypeptide binding]; other site
414684001228	active site
414684001229	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
414684001230	NifU-like domain; Region: NifU; pfam01106
414684001231	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
414684001232	NifQ; Region: NifQ; pfam04891
414684001233	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
414684001234	DDE superfamily endonuclease; Region: DDE_3; pfam13358
414684001235	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
414684001236	Winged helix-turn helix; Region: HTH_29; pfam13551
414684001237	Helix-turn-helix domain; Region: HTH_28; pfam13518
414684001238	Winged helix-turn helix; Region: HTH_33; pfam13592
414684001239	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
414684001240	ADP-ribose binding site [chemical binding]; other site
414684001241	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
414684001242	Domain of unknown function DUF59; Region: DUF59; cl00941
414684001243	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
414684001244	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
414684001245	trimerization site [polypeptide binding]; other site
414684001246	active site
414684001247	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
414684001248	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
414684001249	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
414684001250	catalytic residue [active]
414684001251	FeS assembly protein SufD; Region: sufD; TIGR01981
414684001252	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
414684001253	FeS assembly ATPase SufC; Region: sufC; TIGR01978
414684001254	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
414684001255	Walker A/P-loop; other site
414684001256	ATP binding site [chemical binding]; other site
414684001257	Q-loop/lid; other site
414684001258	ABC transporter signature motif; other site
414684001259	Walker B; other site
414684001260	D-loop; other site
414684001261	H-loop/switch region; other site
414684001262	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
414684001263	putative ABC transporter; Region: ycf24; CHL00085
414684001264	FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944
414684001265	Transcriptional regulator; Region: Rrf2; pfam02082
414684001266	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
414684001267	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
414684001268	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
414684001269	Transposase [DNA replication, recombination, and repair]; Region: COG5433
414684001270	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
414684001271	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684001272	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
414684001273	active site
414684001274	phosphorylation site [posttranslational modification]
414684001275	intermolecular recognition site; other site
414684001276	dimerization interface [polypeptide binding]; other site
414684001277	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
414684001278	DNA binding site [nucleotide binding]
414684001279	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
414684001280	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684001281	phosphorylation site [posttranslational modification]
414684001282	dimer interface [polypeptide binding]; other site
414684001283	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684001284	ATP binding site [chemical binding]; other site
414684001285	Mg2+ binding site [ion binding]; other site
414684001286	G-X-G motif; other site
414684001287	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
414684001288	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
414684001289	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
414684001290	ligand binding site [chemical binding]; other site
414684001291	flexible hinge region; other site
414684001292	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
414684001293	Ligand Binding Site [chemical binding]; other site
414684001294	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
414684001295	FOG: CBS domain [General function prediction only]; Region: COG0517
414684001296	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
414684001297	AAA domain; Region: AAA_23; pfam13476
414684001298	Walker A/P-loop; other site
414684001299	ATP binding site [chemical binding]; other site
414684001300	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
414684001301	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
414684001302	ABC transporter signature motif; other site
414684001303	Walker B; other site
414684001304	D-loop; other site
414684001305	H-loop/switch region; other site
414684001306	Thioredoxin; Region: Thioredoxin_4; pfam13462
414684001307	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
414684001308	Protein of unknown function (DUF721); Region: DUF721; cl02324
414684001309	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
414684001310	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
414684001311	minor groove reading motif; other site
414684001312	helix-hairpin-helix signature motif; other site
414684001313	substrate binding pocket [chemical binding]; other site
414684001314	active site
414684001315	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
414684001316	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
414684001317	DNA binding and oxoG recognition site [nucleotide binding]
414684001318	Protein of unknown function (DUF1194); Region: DUF1194; pfam06707
414684001319	Spore Coat Protein U domain; Region: SCPU; cl02253
414684001320	glycogen branching enzyme; Provisional; Region: PRK05402
414684001321	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
414684001322	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
414684001323	active site
414684001324	catalytic site [active]
414684001325	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
414684001326	trehalose synthase; Region: treS_nterm; TIGR02456
414684001327	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
414684001328	active site
414684001329	catalytic site [active]
414684001330	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
414684001331	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
414684001332	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
414684001333	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
414684001334	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
414684001335	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
414684001336	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
414684001337	active site
414684001338	catalytic site [active]
414684001339	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
414684001340	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
414684001341	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
414684001342	active site
414684001343	homodimer interface [polypeptide binding]; other site
414684001344	catalytic site [active]
414684001345	acceptor binding site [chemical binding]; other site
414684001346	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
414684001347	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
414684001348	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
414684001349	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
414684001350	catalytic residue [active]
414684001351	Protein of unknown function (DUF1045); Region: DUF1045; cl15435
414684001352	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
414684001353	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
414684001354	active site
414684001355	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
414684001356	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
414684001357	NAD(P) binding site [chemical binding]; other site
414684001358	active site
414684001359	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
414684001360	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
414684001361	NAD(P) binding site [chemical binding]; other site
414684001362	active site
414684001363	B12-binding domain/radical SAM domain protein, rhizo-twelve system; Region: B12_rSAM_oligo; TIGR04295
414684001364	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
414684001365	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
414684001366	FeS/SAM binding site; other site
414684001367	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
414684001368	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
414684001369	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
414684001370	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
414684001371	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
414684001372	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
414684001373	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
414684001374	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
414684001375	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
414684001376	Putative phosphatase (DUF442); Region: DUF442; cl17385
414684001377	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
414684001378	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
414684001379	active site
414684001380	SnoaL-like domain; Region: SnoaL_3; pfam13474
414684001381	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
414684001382	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
414684001383	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
414684001384	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
414684001385	NdvC_like  proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; Region: CESA_NdvC_like; cd06435
414684001386	Ligand binding site; other site
414684001387	DXD motif; other site
414684001388	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
414684001389	nucleotide binding site/active site [active]
414684001390	HIT family signature motif; other site
414684001391	catalytic residue [active]
414684001392	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
414684001393	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
414684001394	dimerization interface [polypeptide binding]; other site
414684001395	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
414684001396	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684001397	dimer interface [polypeptide binding]; other site
414684001398	putative CheW interface [polypeptide binding]; other site
414684001399	Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243
414684001400	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
414684001401	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394
414684001402	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
414684001403	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
414684001404	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
414684001405	HicB family; Region: HicB; pfam05534
414684001406	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
414684001407	substrate binding site [chemical binding]; other site
414684001408	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
414684001409	oxyanion hole (OAH) forming residues; other site
414684001410	trimer interface [polypeptide binding]; other site
414684001411	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
414684001412	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
414684001413	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
414684001414	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
414684001415	Prostaglandin dehydrogenases; Region: PGDH; cd05288
414684001416	NAD(P) binding site [chemical binding]; other site
414684001417	substrate binding site [chemical binding]; other site
414684001418	dimer interface [polypeptide binding]; other site
414684001419	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
414684001420	NAD(P) binding site [chemical binding]; other site
414684001421	short chain dehydrogenase; Validated; Region: PRK07069
414684001422	active site
414684001423	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
414684001424	classical (c) SDRs; Region: SDR_c; cd05233
414684001425	NAD(P) binding site [chemical binding]; other site
414684001426	active site
414684001427	Phosphotransferase enzyme family; Region: APH; pfam01636
414684001428	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
414684001429	putative active site [active]
414684001430	putative substrate binding site [chemical binding]; other site
414684001431	ATP binding site [chemical binding]; other site
414684001432	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
414684001433	nudix motif; other site
414684001434	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299
414684001435	heme binding pocket [chemical binding]; other site
414684001436	heme ligand [chemical binding]; other site
414684001437	conserved hypothetical protein, pseudogene;identified by match to protein family HMM PF00107
414684001438	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
414684001439	C-terminal peptidase (prc); Region: prc; TIGR00225
414684001440	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
414684001441	protein binding site [polypeptide binding]; other site
414684001442	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
414684001443	Catalytic dyad [active]
414684001444	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
414684001445	Peptidase family M23; Region: Peptidase_M23; pfam01551
414684001446	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
414684001447	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
414684001448	inhibitor-cofactor binding pocket; inhibition site
414684001449	pyridoxal 5'-phosphate binding site [chemical binding]; other site
414684001450	catalytic residue [active]
414684001451	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
414684001452	Amidinotransferase; Region: Amidinotransf; cl12043
414684001453	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
414684001454	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
414684001455	putative DNA binding site [nucleotide binding]; other site
414684001456	putative Zn2+ binding site [ion binding]; other site
414684001457	AsnC family; Region: AsnC_trans_reg; pfam01037
414684001458	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
414684001459	putative DNA binding site [nucleotide binding]; other site
414684001460	putative Zn2+ binding site [ion binding]; other site
414684001461	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
414684001462	CPxP  motif; other site
414684001463	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
414684001464	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
414684001465	putative active site [active]
414684001466	Zn binding site [ion binding]; other site
414684001467	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
414684001468	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
414684001469	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
414684001470	substrate binding pocket [chemical binding]; other site
414684001471	chain length determination region; other site
414684001472	substrate-Mg2+ binding site; other site
414684001473	catalytic residues [active]
414684001474	aspartate-rich region 1; other site
414684001475	active site lid residues [active]
414684001476	aspartate-rich region 2; other site
414684001477	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
414684001478	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
414684001479	TPP-binding site; other site
414684001480	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
414684001481	PYR/PP interface [polypeptide binding]; other site
414684001482	dimer interface [polypeptide binding]; other site
414684001483	TPP binding site [chemical binding]; other site
414684001484	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
414684001485	Predicted small secreted protein [Function unknown]; Region: COG5510
414684001486	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
414684001487	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
414684001488	RNA binding surface [nucleotide binding]; other site
414684001489	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684001490	S-adenosylmethionine binding site [chemical binding]; other site
414684001491	signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705
414684001492	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
414684001493	tandem repeat interface [polypeptide binding]; other site
414684001494	oligomer interface [polypeptide binding]; other site
414684001495	active site residues [active]
414684001496	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
414684001497	tandem repeat interface [polypeptide binding]; other site
414684001498	oligomer interface [polypeptide binding]; other site
414684001499	active site residues [active]
414684001500	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
414684001501	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
414684001502	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
414684001503	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
414684001504	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
414684001505	substrate-cofactor binding pocket; other site
414684001506	homodimer interface [polypeptide binding]; other site
414684001507	pyridoxal 5'-phosphate binding site [chemical binding]; other site
414684001508	catalytic residue [active]
414684001509	Protein of unknown function (DUF466); Region: DUF466; pfam04328
414684001510	carbon starvation protein A; Provisional; Region: PRK15015
414684001511	Carbon starvation protein CstA; Region: CstA; pfam02554
414684001512	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
414684001513	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
414684001514	active site
414684001515	catalytic site [active]
414684001516	substrate binding site [chemical binding]; other site
414684001517	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
414684001518	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
414684001519	Tetramer interface [polypeptide binding]; other site
414684001520	active site
414684001521	FMN-binding site [chemical binding]; other site
414684001522	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
414684001523	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
414684001524	NAD binding site [chemical binding]; other site
414684001525	homotetramer interface [polypeptide binding]; other site
414684001526	homodimer interface [polypeptide binding]; other site
414684001527	substrate binding site [chemical binding]; other site
414684001528	active site
414684001529	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
414684001530	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
414684001531	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
414684001532	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
414684001533	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
414684001534	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
414684001535	HSP70 interaction site [polypeptide binding]; other site
414684001536	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
414684001537	substrate binding site [polypeptide binding]; other site
414684001538	dimer interface [polypeptide binding]; other site
414684001539	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
414684001540	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
414684001541	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
414684001542	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
414684001543	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
414684001544	Cation efflux family; Region: Cation_efflux; cl00316
414684001545	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
414684001546	PRC-barrel domain; Region: PRC; pfam05239
414684001547	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
414684001548	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
414684001549	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
414684001550	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
414684001551	metal binding site 2 [ion binding]; metal-binding site
414684001552	putative DNA binding helix; other site
414684001553	metal binding site 1 [ion binding]; metal-binding site
414684001554	dimer interface [polypeptide binding]; other site
414684001555	structural Zn2+ binding site [ion binding]; other site
414684001556	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
414684001557	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
414684001558	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
414684001559	short chain dehydrogenase; Provisional; Region: PRK07024
414684001560	NAD(P) binding site [chemical binding]; other site
414684001561	active site
414684001562	SnoaL-like domain; Region: SnoaL_2; pfam12680
414684001563	Pantoate-beta-alanine ligase; Region: PanC; cd00560
414684001564	pantoate--beta-alanine ligase; Region: panC; TIGR00018
414684001565	active site
414684001566	ATP-binding site [chemical binding]; other site
414684001567	pantoate-binding site; other site
414684001568	HXXH motif; other site
414684001569	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
414684001570	dimer interface [polypeptide binding]; other site
414684001571	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
414684001572	active site
414684001573	metal binding site [ion binding]; metal-binding site
414684001574	glutathione binding site [chemical binding]; other site
414684001575	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
414684001576	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
414684001577	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
414684001578	nucleotide binding pocket [chemical binding]; other site
414684001579	K-X-D-G motif; other site
414684001580	catalytic site [active]
414684001581	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
414684001582	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
414684001583	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
414684001584	Dimer interface [polypeptide binding]; other site
414684001585	BRCT sequence motif; other site
414684001586	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
414684001587	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
414684001588	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
414684001589	Walker A/P-loop; other site
414684001590	ATP binding site [chemical binding]; other site
414684001591	Q-loop/lid; other site
414684001592	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
414684001593	ABC transporter signature motif; other site
414684001594	Walker B; other site
414684001595	D-loop; other site
414684001596	H-loop/switch region; other site
414684001597	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
414684001598	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
414684001599	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
414684001600	cell division protein FtsZ, pseudogene
414684001601	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
414684001602	Cell division protein FtsA; Region: FtsA; smart00842
414684001603	Cell division protein FtsA; Region: FtsA; pfam14450
414684001604	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
414684001605	Cell division protein FtsQ; Region: FtsQ; pfam03799
414684001606	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
414684001607	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
414684001608	ATP-grasp domain; Region: ATP-grasp_4; cl17255
414684001609	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
414684001610	FAD binding domain; Region: FAD_binding_4; pfam01565
414684001611	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
414684001612	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
414684001613	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
414684001614	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
414684001615	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
414684001616	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
414684001617	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
414684001618	active site
414684001619	homodimer interface [polypeptide binding]; other site
414684001620	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
414684001621	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
414684001622	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
414684001623	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
414684001624	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
414684001625	Mg++ binding site [ion binding]; other site
414684001626	putative catalytic motif [active]
414684001627	putative substrate binding site [chemical binding]; other site
414684001628	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093
414684001629	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
414684001630	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
414684001631	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
414684001632	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
414684001633	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
414684001634	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
414684001635	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
414684001636	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
414684001637	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
414684001638	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
414684001639	MraW methylase family; Region: Methyltransf_5; cl17771
414684001640	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
414684001641	cell division protein MraZ; Reviewed; Region: PRK00326
414684001642	MraZ protein; Region: MraZ; pfam02381
414684001643	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
414684001644	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
414684001645	amidase catalytic site [active]
414684001646	Zn binding residues [ion binding]; other site
414684001647	substrate binding site [chemical binding]; other site
414684001648	EamA-like transporter family; Region: EamA; pfam00892
414684001649	ABC transporter ATPase component; Reviewed; Region: PRK11147
414684001650	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
414684001651	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
414684001652	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
414684001653	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
414684001654	putative metal binding site [ion binding]; other site
414684001655	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
414684001656	HSP70 interaction site [polypeptide binding]; other site
414684001657	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
414684001658	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
414684001659	Coenzyme A binding pocket [chemical binding]; other site
414684001660	5-oxoprolinase; Region: PLN02666
414684001661	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
414684001662	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
414684001663	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
414684001664	TMAO/DMSO reductase; Reviewed; Region: PRK05363
414684001665	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
414684001666	Moco binding site; other site
414684001667	metal coordination site [ion binding]; other site
414684001668	CHASE3 domain; Region: CHASE3; cl05000
414684001669	PAS fold; Region: PAS_7; pfam12860
414684001670	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
414684001671	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684001672	dimer interface [polypeptide binding]; other site
414684001673	phosphorylation site [posttranslational modification]
414684001674	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684001675	ATP binding site [chemical binding]; other site
414684001676	Mg2+ binding site [ion binding]; other site
414684001677	G-X-G motif; other site
414684001678	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
414684001679	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684001680	active site
414684001681	phosphorylation site [posttranslational modification]
414684001682	intermolecular recognition site; other site
414684001683	dimerization interface [polypeptide binding]; other site
414684001684	Transcriptional regulator [Transcription]; Region: LysR; COG0583
414684001685	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
414684001686	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
414684001687	putative effector binding pocket; other site
414684001688	dimerization interface [polypeptide binding]; other site
414684001689	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
414684001690	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
414684001691	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
414684001692	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
414684001693	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
414684001694	DsbD alpha interface [polypeptide binding]; other site
414684001695	catalytic residues [active]
414684001696	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
414684001697	putative catalytic residue [active]
414684001698	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
414684001699	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
414684001700	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
414684001701	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
414684001702	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
414684001703	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
414684001704	enoyl-CoA hydratase; Provisional; Region: PRK08260
414684001705	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
414684001706	substrate binding site [chemical binding]; other site
414684001707	oxyanion hole (OAH) forming residues; other site
414684001708	trimer interface [polypeptide binding]; other site
414684001709	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
414684001710	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
414684001711	ATP binding site [chemical binding]; other site
414684001712	putative Mg++ binding site [ion binding]; other site
414684001713	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
414684001714	nucleotide binding region [chemical binding]; other site
414684001715	ATP-binding site [chemical binding]; other site
414684001716	DEAD/H associated; Region: DEAD_assoc; pfam08494
414684001717	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
414684001718	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
414684001719	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
414684001720	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
414684001721	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
414684001722	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
414684001723	putative dimer interface [polypeptide binding]; other site
414684001724	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
414684001725	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
414684001726	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
414684001727	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
414684001728	DNA ligase, ATP-dependent, PP_1105 family; Region: DNA_lig_bact; TIGR04120
414684001729	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
414684001730	active site
414684001731	DNA binding site [nucleotide binding]
414684001732	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
414684001733	DNA binding site [nucleotide binding]
414684001734	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
414684001735	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533
414684001736	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
414684001737	NAD binding site [chemical binding]; other site
414684001738	homotetramer interface [polypeptide binding]; other site
414684001739	homodimer interface [polypeptide binding]; other site
414684001740	substrate binding site [chemical binding]; other site
414684001741	active site
414684001742	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
414684001743	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
414684001744	active site
414684001745	Zn binding site [ion binding]; other site
414684001746	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
414684001747	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
414684001748	putative metal binding site; other site
414684001749	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
414684001750	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
414684001751	sequence-specific DNA binding site [nucleotide binding]; other site
414684001752	salt bridge; other site
414684001753	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
414684001754	active site
414684001755	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
414684001756	SLBB domain; Region: SLBB; pfam10531
414684001757	SLBB domain; Region: SLBB; pfam10531
414684001758	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
414684001759	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
414684001760	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
414684001761	putative active site; other site
414684001762	catalytic triad [active]
414684001763	putative dimer interface [polypeptide binding]; other site
414684001764	Transcriptional regulators [Transcription]; Region: MarR; COG1846
414684001765	MarR family; Region: MarR_2; cl17246
414684001766	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
414684001767	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
414684001768	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
414684001769	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
414684001770	Walker A/P-loop; other site
414684001771	ATP binding site [chemical binding]; other site
414684001772	Q-loop/lid; other site
414684001773	ABC transporter signature motif; other site
414684001774	Walker B; other site
414684001775	D-loop; other site
414684001776	H-loop/switch region; other site
414684001777	FecCD transport family; Region: FecCD; pfam01032
414684001778	putative PBP binding regions; other site
414684001779	ABC-ATPase subunit  interface; other site
414684001780	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
414684001781	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
414684001782	intersubunit interface [polypeptide binding]; other site
414684001783	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
414684001784	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
414684001785	N-terminal plug; other site
414684001786	ligand-binding site [chemical binding]; other site
414684001787	AAA domain; Region: AAA_28; pfam13521
414684001788	AAA domain; Region: AAA_17; pfam13207
414684001789	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
414684001790	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
414684001791	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
414684001792	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
414684001793	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
414684001794	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
414684001795	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
414684001796	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
414684001797	PhoU domain; Region: PhoU; pfam01895
414684001798	PhoU domain; Region: PhoU; pfam01895
414684001799	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
414684001800	MgtE intracellular N domain; Region: MgtE_N; cl15244
414684001801	FliG C-terminal domain; Region: FliG_C; pfam01706
414684001802	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
414684001803	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
414684001804	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
414684001805	HlyD family secretion protein; Region: HlyD_3; pfam13437
414684001806	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
414684001807	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
414684001808	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
414684001809	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
414684001810	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
414684001811	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
414684001812	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
414684001813	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
414684001814	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
414684001815	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684001816	active site
414684001817	phosphorylation site [posttranslational modification]
414684001818	intermolecular recognition site; other site
414684001819	dimerization interface [polypeptide binding]; other site
414684001820	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
414684001821	DNA binding site [nucleotide binding]
414684001822	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
414684001823	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
414684001824	dimerization interface [polypeptide binding]; other site
414684001825	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684001826	ATP binding site [chemical binding]; other site
414684001827	Mg2+ binding site [ion binding]; other site
414684001828	G-X-G motif; other site
414684001829	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
414684001830	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
414684001831	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
414684001832	elongation factor Tu; Reviewed; Region: PRK00049
414684001833	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
414684001834	G1 box; other site
414684001835	GEF interaction site [polypeptide binding]; other site
414684001836	GTP/Mg2+ binding site [chemical binding]; other site
414684001837	Switch I region; other site
414684001838	G2 box; other site
414684001839	G3 box; other site
414684001840	Switch II region; other site
414684001841	G4 box; other site
414684001842	G5 box; other site
414684001843	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
414684001844	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
414684001845	Antibiotic Binding Site [chemical binding]; other site
414684001846	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
414684001847	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
414684001848	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
414684001849	putative homodimer interface [polypeptide binding]; other site
414684001850	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
414684001851	heterodimer interface [polypeptide binding]; other site
414684001852	homodimer interface [polypeptide binding]; other site
414684001853	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
414684001854	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
414684001855	23S rRNA interface [nucleotide binding]; other site
414684001856	L7/L12 interface [polypeptide binding]; other site
414684001857	putative thiostrepton binding site; other site
414684001858	L25 interface [polypeptide binding]; other site
414684001859	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
414684001860	mRNA/rRNA interface [nucleotide binding]; other site
414684001861	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
414684001862	23S rRNA interface [nucleotide binding]; other site
414684001863	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
414684001864	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
414684001865	peripheral dimer interface [polypeptide binding]; other site
414684001866	core dimer interface [polypeptide binding]; other site
414684001867	L10 interface [polypeptide binding]; other site
414684001868	L11 interface [polypeptide binding]; other site
414684001869	putative EF-Tu interaction site [polypeptide binding]; other site
414684001870	putative EF-G interaction site [polypeptide binding]; other site
414684001871	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
414684001872	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
414684001873	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
414684001874	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
414684001875	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
414684001876	RPB12 interaction site [polypeptide binding]; other site
414684001877	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
414684001878	RPB1 interaction site [polypeptide binding]; other site
414684001879	RPB11 interaction site [polypeptide binding]; other site
414684001880	RPB10 interaction site [polypeptide binding]; other site
414684001881	RPB3 interaction site [polypeptide binding]; other site
414684001882	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
414684001883	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
414684001884	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
414684001885	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
414684001886	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
414684001887	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
414684001888	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
414684001889	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
414684001890	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
414684001891	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
414684001892	DNA binding site [nucleotide binding]
414684001893	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
414684001894	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
414684001895	non-specific DNA binding site [nucleotide binding]; other site
414684001896	salt bridge; other site
414684001897	sequence-specific DNA binding site [nucleotide binding]; other site
414684001898	HipA N-terminal domain; Region: Couple_hipA; cl11853
414684001899	HipA-like N-terminal domain; Region: HipA_N; pfam07805
414684001900	HipA-like C-terminal domain; Region: HipA_C; pfam07804
414684001901	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
414684001902	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
414684001903	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
414684001904	FeS/SAM binding site; other site
414684001905	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
414684001906	S17 interaction site [polypeptide binding]; other site
414684001907	S8 interaction site; other site
414684001908	16S rRNA interaction site [nucleotide binding]; other site
414684001909	streptomycin interaction site [chemical binding]; other site
414684001910	23S rRNA interaction site [nucleotide binding]; other site
414684001911	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
414684001912	30S ribosomal protein S7; Validated; Region: PRK05302
414684001913	elongation factor G; Reviewed; Region: PRK00007
414684001914	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
414684001915	G1 box; other site
414684001916	putative GEF interaction site [polypeptide binding]; other site
414684001917	GTP/Mg2+ binding site [chemical binding]; other site
414684001918	Switch I region; other site
414684001919	G2 box; other site
414684001920	G3 box; other site
414684001921	Switch II region; other site
414684001922	G4 box; other site
414684001923	G5 box; other site
414684001924	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
414684001925	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
414684001926	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
414684001927	elongation factor Tu; Reviewed; Region: PRK00049
414684001928	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
414684001929	G1 box; other site
414684001930	GEF interaction site [polypeptide binding]; other site
414684001931	GTP/Mg2+ binding site [chemical binding]; other site
414684001932	Switch I region; other site
414684001933	G2 box; other site
414684001934	G3 box; other site
414684001935	Switch II region; other site
414684001936	G4 box; other site
414684001937	G5 box; other site
414684001938	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
414684001939	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
414684001940	Antibiotic Binding Site [chemical binding]; other site
414684001941	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
414684001942	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
414684001943	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
414684001944	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
414684001945	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
414684001946	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
414684001947	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
414684001948	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
414684001949	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
414684001950	putative translocon binding site; other site
414684001951	protein-rRNA interface [nucleotide binding]; other site
414684001952	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
414684001953	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
414684001954	G-X-X-G motif; other site
414684001955	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
414684001956	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
414684001957	23S rRNA interface [nucleotide binding]; other site
414684001958	5S rRNA interface [nucleotide binding]; other site
414684001959	putative antibiotic binding site [chemical binding]; other site
414684001960	L25 interface [polypeptide binding]; other site
414684001961	L27 interface [polypeptide binding]; other site
414684001962	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
414684001963	23S rRNA interface [nucleotide binding]; other site
414684001964	putative translocon interaction site; other site
414684001965	signal recognition particle (SRP54) interaction site; other site
414684001966	L23 interface [polypeptide binding]; other site
414684001967	trigger factor interaction site; other site
414684001968	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
414684001969	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
414684001970	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
414684001971	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
414684001972	RNA binding site [nucleotide binding]; other site
414684001973	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
414684001974	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
414684001975	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
414684001976	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
414684001977	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
414684001978	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
414684001979	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
414684001980	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
414684001981	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
414684001982	23S rRNA interface [nucleotide binding]; other site
414684001983	L21e interface [polypeptide binding]; other site
414684001984	5S rRNA interface [nucleotide binding]; other site
414684001985	L27 interface [polypeptide binding]; other site
414684001986	L5 interface [polypeptide binding]; other site
414684001987	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
414684001988	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
414684001989	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
414684001990	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
414684001991	23S rRNA binding site [nucleotide binding]; other site
414684001992	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
414684001993	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
414684001994	SecY translocase; Region: SecY; pfam00344
414684001995	adenylate kinase; Reviewed; Region: adk; PRK00279
414684001996	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
414684001997	AMP-binding site [chemical binding]; other site
414684001998	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
414684001999	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
414684002000	30S ribosomal protein S13; Region: bact_S13; TIGR03631
414684002001	30S ribosomal protein S11; Validated; Region: PRK05309
414684002002	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
414684002003	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
414684002004	alphaNTD - beta interaction site [polypeptide binding]; other site
414684002005	alphaNTD homodimer interface [polypeptide binding]; other site
414684002006	alphaNTD - beta' interaction site [polypeptide binding]; other site
414684002007	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
414684002008	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
414684002009	PRC-barrel domain; Region: PRC; pfam05239
414684002010	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
414684002011	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
414684002012	VacJ like lipoprotein; Region: VacJ; cl01073
414684002013	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
414684002014	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
414684002015	acyl-CoA synthetase; Validated; Region: PRK09192
414684002016	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
414684002017	acyl-activating enzyme (AAE) consensus motif; other site
414684002018	active site
414684002019	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
414684002020	NAD(P) binding site [chemical binding]; other site
414684002021	active site
414684002022	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
414684002023	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
414684002024	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
414684002025	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
414684002026	catalytic residue [active]
414684002027	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
414684002028	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
414684002029	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
414684002030	putative active site [active]
414684002031	putative metal binding site [ion binding]; other site
414684002032	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
414684002033	Predicted permeases [General function prediction only]; Region: COG0795
414684002034	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
414684002035	Predicted permeases [General function prediction only]; Region: COG0795
414684002036	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
414684002037	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
414684002038	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
414684002039	active site
414684002040	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
414684002041	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
414684002042	AsnC family; Region: AsnC_trans_reg; pfam01037
414684002043	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
414684002044	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
414684002045	hexamer interface [polypeptide binding]; other site
414684002046	ligand binding site [chemical binding]; other site
414684002047	putative active site [active]
414684002048	NAD(P) binding site [chemical binding]; other site
414684002049	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
414684002050	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
414684002051	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
414684002052	Putative phosphatase (DUF442); Region: DUF442; cl17385
414684002053	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
414684002054	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
414684002055	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
414684002056	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
414684002057	catalytic core [active]
414684002058	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
414684002059	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
414684002060	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
414684002061	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
414684002062	active site
414684002063	Substrate binding site; other site
414684002064	Mg++ binding site; other site
414684002065	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684002066	S-adenosylmethionine binding site [chemical binding]; other site
414684002067	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
414684002068	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
414684002069	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
414684002070	putative ADP-binding pocket [chemical binding]; other site
414684002071	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
414684002072	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
414684002073	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
414684002074	putative catalytic site [active]
414684002075	putative metal binding site [ion binding]; other site
414684002076	putative phosphate binding site [ion binding]; other site
414684002077	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
414684002078	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
414684002079	tetramer interface [polypeptide binding]; other site
414684002080	pyridoxal 5'-phosphate binding site [chemical binding]; other site
414684002081	catalytic residue [active]
414684002082	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00154
414684002083	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
414684002084	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
414684002085	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
414684002086	Subunit I/III interface [polypeptide binding]; other site
414684002087	D-pathway; other site
414684002088	Subunit I/VIIc interface [polypeptide binding]; other site
414684002089	Subunit I/IV interface [polypeptide binding]; other site
414684002090	Subunit I/II interface [polypeptide binding]; other site
414684002091	Low-spin heme (heme a) binding site [chemical binding]; other site
414684002092	Subunit I/VIIa interface [polypeptide binding]; other site
414684002093	Subunit I/VIa interface [polypeptide binding]; other site
414684002094	Dimer interface; other site
414684002095	Putative water exit pathway; other site
414684002096	Binuclear center (heme a3/CuB) [ion binding]; other site
414684002097	K-pathway; other site
414684002098	Subunit I/Vb interface [polypeptide binding]; other site
414684002099	Putative proton exit pathway; other site
414684002100	Subunit I/VIb interface; other site
414684002101	Subunit I/VIc interface [polypeptide binding]; other site
414684002102	Electron transfer pathway; other site
414684002103	Subunit I/VIIIb interface [polypeptide binding]; other site
414684002104	Subunit I/VIIb interface [polypeptide binding]; other site
414684002105	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
414684002106	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
414684002107	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
414684002108	Transposase [DNA replication, recombination, and repair]; Region: COG5433
414684002109	Protein of unknown function (DUF3422); Region: DUF3422; pfam11902
414684002110	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
414684002111	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
414684002112	dimer interface [polypeptide binding]; other site
414684002113	putative functional site; other site
414684002114	putative MPT binding site; other site
414684002115	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
414684002116	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
414684002117	P-loop; other site
414684002118	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
414684002119	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
414684002120	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
414684002121	FHIPEP family; Region: FHIPEP; pfam00771
414684002122	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
414684002123	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
414684002124	active site
414684002125	phosphorylation site [posttranslational modification]
414684002126	intermolecular recognition site; other site
414684002127	dimerization interface [polypeptide binding]; other site
414684002128	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
414684002129	Walker A motif; other site
414684002130	ATP binding site [chemical binding]; other site
414684002131	Walker B motif; other site
414684002132	arginine finger; other site
414684002133	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
414684002134	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
414684002135	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
414684002136	Flagellar assembly protein FliH; Region: FliH; pfam02108
414684002137	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
414684002138	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
414684002139	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
414684002140	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
414684002141	Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140
414684002142	putative active site [active]
414684002143	catalytic site [active]
414684002144	Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143
414684002145	putative active site [active]
414684002146	catalytic site [active]
414684002147	CsbD-like; Region: CsbD; pfam05532
414684002148	Protein of unknown function (DUF3450); Region: DUF3450; pfam11932
414684002149	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
414684002150	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
414684002151	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
414684002152	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
414684002153	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
414684002154	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
414684002155	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
414684002156	binding surface
414684002157	TPR motif; other site
414684002158	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
414684002159	binding surface
414684002160	TPR motif; other site
414684002161	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
414684002162	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
414684002163	putative active site [active]
414684002164	putative dimer interface [polypeptide binding]; other site
414684002165	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
414684002166	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
414684002167	N-terminal plug; other site
414684002168	ligand-binding site [chemical binding]; other site
414684002169	Protein of unknown function (DUF1491); Region: DUF1491; pfam07372
414684002170	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
414684002171	methionine sulfoxide reductase A; Provisional; Region: PRK00058
414684002172	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
414684002173	HlyD family secretion protein; Region: HlyD_3; pfam13437
414684002174	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
414684002175	Protein export membrane protein; Region: SecD_SecF; cl14618
414684002176	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
414684002177	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
414684002178	NAD binding site [chemical binding]; other site
414684002179	substrate binding site [chemical binding]; other site
414684002180	homodimer interface [polypeptide binding]; other site
414684002181	active site
414684002182	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
414684002183	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
414684002184	substrate binding site; other site
414684002185	tetramer interface; other site
414684002186	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
414684002187	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
414684002188	active site
414684002189	motif I; other site
414684002190	motif II; other site
414684002191	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
414684002192	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
414684002193	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
414684002194	Walker A/P-loop; other site
414684002195	ATP binding site [chemical binding]; other site
414684002196	Q-loop/lid; other site
414684002197	ABC transporter signature motif; other site
414684002198	Walker B; other site
414684002199	D-loop; other site
414684002200	H-loop/switch region; other site
414684002201	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
414684002202	putative carbohydrate binding site [chemical binding]; other site
414684002203	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
414684002204	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
414684002205	inhibitor-cofactor binding pocket; inhibition site
414684002206	pyridoxal 5'-phosphate binding site [chemical binding]; other site
414684002207	catalytic residue [active]
414684002208	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
414684002209	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
414684002210	active site
414684002211	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
414684002212	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
414684002213	active site
414684002214	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
414684002215	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
414684002216	Probable Catalytic site; other site
414684002217	metal-binding site
414684002218	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
414684002219	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
414684002220	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
414684002221	non-specific DNA binding site [nucleotide binding]; other site
414684002222	salt bridge; other site
414684002223	sequence-specific DNA binding site [nucleotide binding]; other site
414684002224	Methyltransferase domain; Region: Methyltransf_12; pfam08242
414684002225	Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119
414684002226	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
414684002227	active site
414684002228	dimer interface [polypeptide binding]; other site
414684002229	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
414684002230	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
414684002231	putative trimer interface [polypeptide binding]; other site
414684002232	putative CoA binding site [chemical binding]; other site
414684002233	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
414684002234	MarR family; Region: MarR; pfam01047
414684002235	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
414684002236	Domain of unknown function (DUF892); Region: DUF892; pfam05974
414684002237	transcription termination factor, pseudogene;identified by match to protein family HMM PF00353
414684002238	fructokinase; Reviewed; Region: PRK09557
414684002239	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
414684002240	nucleotide binding site [chemical binding]; other site
414684002241	AzlC protein; Region: AzlC; pfam03591
414684002242	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
414684002243	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
414684002244	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
414684002245	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
414684002246	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
414684002247	ligand binding site [chemical binding]; other site
414684002248	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
414684002249	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
414684002250	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
414684002251	ligand binding site [chemical binding]; other site
414684002252	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
414684002253	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
414684002254	DNA binding residues [nucleotide binding]
414684002255	dimerization interface [polypeptide binding]; other site
414684002256	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
414684002257	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
414684002258	DNA binding residues [nucleotide binding]
414684002259	dimerization interface [polypeptide binding]; other site
414684002260	Phasin protein; Region: Phasin_2; cl11491
414684002261	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
414684002262	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
414684002263	EamA-like transporter family; Region: EamA; pfam00892
414684002264	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
414684002265	N-acetyl-D-glucosamine binding site [chemical binding]; other site
414684002266	catalytic residue [active]
414684002267	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841
414684002268	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
414684002269	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684002270	S-adenosylmethionine binding site [chemical binding]; other site
414684002271	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
414684002272	LrgA family; Region: LrgA; pfam03788
414684002273	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
414684002274	putative active site [active]
414684002275	putative metal binding site [ion binding]; other site
414684002276	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
414684002277	short chain dehydrogenase; Provisional; Region: PRK06701
414684002278	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
414684002279	NAD binding site [chemical binding]; other site
414684002280	metal binding site [ion binding]; metal-binding site
414684002281	active site
414684002282	RNA polymerase sigma factor; Provisional; Region: PRK12547
414684002283	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
414684002284	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
414684002285	DNA binding residues [nucleotide binding]
414684002286	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
414684002287	homodimer interface [polypeptide binding]; other site
414684002288	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
414684002289	active site pocket [active]
414684002290	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
414684002291	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
414684002292	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
414684002293	active site
414684002294	SnoaL-like domain; Region: SnoaL_2; pfam12680
414684002295	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
414684002296	DEAD-like helicases superfamily; Region: DEXDc; smart00487
414684002297	ATP binding site [chemical binding]; other site
414684002298	Mg++ binding site [ion binding]; other site
414684002299	motif III; other site
414684002300	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
414684002301	nucleotide binding region [chemical binding]; other site
414684002302	ATP-binding site [chemical binding]; other site
414684002303	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
414684002304	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
414684002305	G1 box; other site
414684002306	putative GEF interaction site [polypeptide binding]; other site
414684002307	GTP/Mg2+ binding site [chemical binding]; other site
414684002308	Switch I region; other site
414684002309	G2 box; other site
414684002310	G3 box; other site
414684002311	Switch II region; other site
414684002312	G4 box; other site
414684002313	G5 box; other site
414684002314	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
414684002315	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684002316	dimer interface [polypeptide binding]; other site
414684002317	putative CheW interface [polypeptide binding]; other site
414684002318	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
414684002319	putative active site pocket [active]
414684002320	dimerization interface [polypeptide binding]; other site
414684002321	putative catalytic residue [active]
414684002322	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
414684002323	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
414684002324	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
414684002325	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
414684002326	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
414684002327	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
414684002328	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
414684002329	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
414684002330	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
414684002331	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
414684002332	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
414684002333	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
414684002334	flagellar motor switch protein FliM; Region: fliM_switch; TIGR01397
414684002335	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
414684002336	Uncharacterized conserved protein [Function unknown]; Region: COG3334
414684002337	Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219
414684002338	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
414684002339	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
414684002340	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
414684002341	ligand binding site [chemical binding]; other site
414684002342	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
414684002343	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
414684002344	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
414684002345	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004
414684002346	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
414684002347	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
414684002348	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
414684002349	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790
414684002350	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
414684002351	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
414684002352	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
414684002353	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
414684002354	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
414684002355	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
414684002356	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684002357	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
414684002358	putative active site [active]
414684002359	heme pocket [chemical binding]; other site
414684002360	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684002361	dimer interface [polypeptide binding]; other site
414684002362	phosphorylation site [posttranslational modification]
414684002363	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684002364	ATP binding site [chemical binding]; other site
414684002365	Mg2+ binding site [ion binding]; other site
414684002366	G-X-G motif; other site
414684002367	Response regulator receiver domain; Region: Response_reg; pfam00072
414684002368	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684002369	active site
414684002370	phosphorylation site [posttranslational modification]
414684002371	intermolecular recognition site; other site
414684002372	dimerization interface [polypeptide binding]; other site
414684002373	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
414684002374	HAMP domain; Region: HAMP; pfam00672
414684002375	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
414684002376	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684002377	dimer interface [polypeptide binding]; other site
414684002378	putative CheW interface [polypeptide binding]; other site
414684002379	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
414684002380	HAMP domain; Region: HAMP; pfam00672
414684002381	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
414684002382	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684002383	dimer interface [polypeptide binding]; other site
414684002384	putative CheW interface [polypeptide binding]; other site
414684002385	recombinase A; Provisional; Region: recA; PRK09354
414684002386	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
414684002387	hexamer interface [polypeptide binding]; other site
414684002388	Walker A motif; other site
414684002389	ATP binding site [chemical binding]; other site
414684002390	Walker B motif; other site
414684002391	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
414684002392	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
414684002393	motif 1; other site
414684002394	active site
414684002395	motif 2; other site
414684002396	motif 3; other site
414684002397	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
414684002398	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
414684002399	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
414684002400	Walker A motif; other site
414684002401	ATP binding site [chemical binding]; other site
414684002402	Walker B motif; other site
414684002403	arginine finger; other site
414684002404	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
414684002405	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
414684002406	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
414684002407	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
414684002408	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
414684002409	cyclase homology domain; Region: CHD; cd07302
414684002410	nucleotidyl binding site; other site
414684002411	metal binding site [ion binding]; metal-binding site
414684002412	dimer interface [polypeptide binding]; other site
414684002413	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
414684002414	isocitrate dehydrogenase; Validated; Region: PRK09222
414684002415	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
414684002416	GcrA cell cycle regulator; Region: GcrA; cl11564
414684002417	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
414684002418	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684002419	putative active site [active]
414684002420	heme pocket [chemical binding]; other site
414684002421	PAS domain; Region: PAS; smart00091
414684002422	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
414684002423	putative active site [active]
414684002424	heme pocket [chemical binding]; other site
414684002425	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684002426	putative active site [active]
414684002427	heme pocket [chemical binding]; other site
414684002428	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
414684002429	HWE histidine kinase; Region: HWE_HK; smart00911
414684002430	RES domain; Region: RES; pfam08808
414684002431	isocitrate dehydrogenase, NADP-dependent, pseudogene;synonym identified by match to protein family HMM PF03781
414684002432	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
414684002433	Cytochrome C' Region: Cytochrom_C_2; pfam01322
414684002434	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
414684002435	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
414684002436	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
414684002437	active site 2 [active]
414684002438	active site 1 [active]
414684002439	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
414684002440	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
414684002441	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
414684002442	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
414684002443	active site
414684002444	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
414684002445	TSCPD domain; Region: TSCPD; pfam12637
414684002446	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
414684002447	Predicted integral membrane protein [Function unknown]; Region: COG0392
414684002448	NADH dehydrogenase; Validated; Region: PRK08183
414684002449	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
414684002450	mce related protein; Region: MCE; pfam02470
414684002451	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
414684002452	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684002453	S-adenosylmethionine binding site [chemical binding]; other site
414684002454	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
414684002455	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
414684002456	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
414684002457	dimerization interface [polypeptide binding]; other site
414684002458	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684002459	dimer interface [polypeptide binding]; other site
414684002460	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
414684002461	putative CheW interface [polypeptide binding]; other site
414684002462	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
414684002463	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
414684002464	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
414684002465	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
414684002466	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
414684002467	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
414684002468	carboxyltransferase (CT) interaction site; other site
414684002469	biotinylation site [posttranslational modification]; other site
414684002470	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
414684002471	Dehydroquinase class II; Region: DHquinase_II; pfam01220
414684002472	active site
414684002473	trimer interface [polypeptide binding]; other site
414684002474	dimer interface [polypeptide binding]; other site
414684002475	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
414684002476	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
414684002477	catalytic residues [active]
414684002478	Peptidase family M48; Region: Peptidase_M48; cl12018
414684002479	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
414684002480	binding surface
414684002481	Tetratricopeptide repeat; Region: TPR_16; pfam13432
414684002482	TPR motif; other site
414684002483	aspartate aminotransferase; Provisional; Region: PRK05764
414684002484	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
414684002485	pyridoxal 5'-phosphate binding site [chemical binding]; other site
414684002486	homodimer interface [polypeptide binding]; other site
414684002487	catalytic residue [active]
414684002488	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
414684002489	putative protease; Provisional; Region: PRK15447
414684002490	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
414684002491	Peptidase family U32; Region: Peptidase_U32; pfam01136
414684002492	SCP-2 sterol transfer family; Region: SCP2; cl01225
414684002493	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
414684002494	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
414684002495	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
414684002496	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
414684002497	Ligand Binding Site [chemical binding]; other site
414684002498	Winged helix-turn helix; Region: HTH_33; pfam13592
414684002499	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
414684002500	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
414684002501	Surface antigen; Region: Bac_surface_Ag; pfam01103
414684002502	haemagglutination activity domain; Region: Haemagg_act; pfam05860
414684002503	M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342
414684002504	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
414684002505	binding surface
414684002506	TPR motif; other site
414684002507	TPR repeat; Region: TPR_11; pfam13414
414684002508	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
414684002509	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
414684002510	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
414684002511	N-terminal plug; other site
414684002512	ligand-binding site [chemical binding]; other site
414684002513	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
414684002514	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
414684002515	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
414684002516	muropeptide transporter; Reviewed; Region: ampG; PRK11902
414684002517	muropeptide transporter; Validated; Region: ampG; cl17669
414684002518	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
414684002519	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
414684002520	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
414684002521	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
414684002522	active site
414684002523	Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219
414684002524	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
414684002525	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684002526	active site
414684002527	phosphorylation site [posttranslational modification]
414684002528	intermolecular recognition site; other site
414684002529	dimerization interface [polypeptide binding]; other site
414684002530	GAF domain; Region: GAF; cl17456
414684002531	PAS domain S-box; Region: sensory_box; TIGR00229
414684002532	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684002533	putative active site [active]
414684002534	heme pocket [chemical binding]; other site
414684002535	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
414684002536	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
414684002537	metal binding site [ion binding]; metal-binding site
414684002538	active site
414684002539	I-site; other site
414684002540	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
414684002541	NAD synthetase; Provisional; Region: PRK13981
414684002542	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
414684002543	multimer interface [polypeptide binding]; other site
414684002544	active site
414684002545	catalytic triad [active]
414684002546	protein interface 1 [polypeptide binding]; other site
414684002547	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
414684002548	homodimer interface [polypeptide binding]; other site
414684002549	NAD binding pocket [chemical binding]; other site
414684002550	ATP binding pocket [chemical binding]; other site
414684002551	Mg binding site [ion binding]; other site
414684002552	active-site loop [active]
414684002553	FAD dependent oxidoreductase, pseudogene;[contains] Rieske [2Fe-2S] domain
414684002554	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
414684002555	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
414684002556	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
414684002557	peptide binding site [polypeptide binding]; other site
414684002558	dimer interface [polypeptide binding]; other site
414684002559	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
414684002560	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
414684002561	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
414684002562	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
414684002563	nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188
414684002564	active site
414684002565	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
414684002566	dimerization interface [polypeptide binding]; other site
414684002567	metal binding site [ion binding]; metal-binding site
414684002568	Heavy-metal resistance; Region: Metal_resist; pfam13801
414684002569	RNA polymerase sigma factor; Reviewed; Region: PRK05602
414684002570	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
414684002571	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
414684002572	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
414684002573	EF-hand domain pair; Region: EF_hand_5; pfam13499
414684002574	pseudo EF-hand loop; other site
414684002575	peptide binding pocket; other site
414684002576	Ca2+ binding site [ion binding]; other site
414684002577	enoyl-CoA hydratase; Provisional; Region: PRK06127
414684002578	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
414684002579	substrate binding site [chemical binding]; other site
414684002580	oxyanion hole (OAH) forming residues; other site
414684002581	trimer interface [polypeptide binding]; other site
414684002582	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684002583	S-adenosylmethionine binding site [chemical binding]; other site
414684002584	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
414684002585	cyclase homology domain; Region: CHD; cd07302
414684002586	nucleotidyl binding site; other site
414684002587	metal binding site [ion binding]; metal-binding site
414684002588	dimer interface [polypeptide binding]; other site
414684002589	glutamyl-tRNA synthetase; Provisional; Region: PRK12558
414684002590	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
414684002591	active site
414684002592	HIGH motif; other site
414684002593	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
414684002594	active site
414684002595	KMSKS motif; other site
414684002596	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
414684002597	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
414684002598	active site
414684002599	HIGH motif; other site
414684002600	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
414684002601	KMSKS motif; other site
414684002602	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
414684002603	tRNA binding surface [nucleotide binding]; other site
414684002604	anticodon binding site; other site
414684002605	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
414684002606	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
414684002607	active site
414684002608	catalytic residues [active]
414684002609	metal binding site [ion binding]; metal-binding site
414684002610	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
414684002611	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
414684002612	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
414684002613	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
414684002614	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
414684002615	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
414684002616	RNA binding surface [nucleotide binding]; other site
414684002617	Transposase domain (DUF772); Region: DUF772; pfam05598
414684002618	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
414684002619	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
414684002620	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
414684002621	Transposase domain (DUF772); Region: DUF772; pfam05598
414684002622	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
414684002623	Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978
414684002624	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
414684002625	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
414684002626	putative GSH binding site [chemical binding]; other site
414684002627	catalytic residues [active]
414684002628	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
414684002629	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
414684002630	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
414684002631	dimerization interface [polypeptide binding]; other site
414684002632	ATP binding site [chemical binding]; other site
414684002633	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
414684002634	dimerization interface [polypeptide binding]; other site
414684002635	ATP binding site [chemical binding]; other site
414684002636	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
414684002637	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
414684002638	putative active site [active]
414684002639	catalytic triad [active]
414684002640	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
414684002641	Na binding site [ion binding]; other site
414684002642	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
414684002643	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684002644	dimer interface [polypeptide binding]; other site
414684002645	phosphorylation site [posttranslational modification]
414684002646	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684002647	ATP binding site [chemical binding]; other site
414684002648	Mg2+ binding site [ion binding]; other site
414684002649	G-X-G motif; other site
414684002650	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
414684002651	PAS domain; Region: PAS_9; pfam13426
414684002652	putative active site [active]
414684002653	heme pocket [chemical binding]; other site
414684002654	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
414684002655	active site
414684002656	catalytic site [active]
414684002657	substrate binding site [chemical binding]; other site
414684002658	Response regulator receiver domain; Region: Response_reg; pfam00072
414684002659	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684002660	active site
414684002661	phosphorylation site [posttranslational modification]
414684002662	intermolecular recognition site; other site
414684002663	dimerization interface [polypeptide binding]; other site
414684002664	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
414684002665	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
414684002666	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
414684002667	Protein export membrane protein; Region: SecD_SecF; pfam02355
414684002668	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
414684002669	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
414684002670	substrate-cofactor binding pocket; other site
414684002671	pyridoxal 5'-phosphate binding site [chemical binding]; other site
414684002672	catalytic residue [active]
414684002673	aminotransferase; Provisional; Region: PRK06105
414684002674	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
414684002675	inhibitor-cofactor binding pocket; inhibition site
414684002676	pyridoxal 5'-phosphate binding site [chemical binding]; other site
414684002677	catalytic residue [active]
414684002678	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
414684002679	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
414684002680	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
414684002681	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
414684002682	DNA-binding site [nucleotide binding]; DNA binding site
414684002683	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
414684002684	pyridoxal 5'-phosphate binding site [chemical binding]; other site
414684002685	homodimer interface [polypeptide binding]; other site
414684002686	osmolarity response regulator; Provisional; Region: ompR; PRK09468
414684002687	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684002688	active site
414684002689	phosphorylation site [posttranslational modification]
414684002690	intermolecular recognition site; other site
414684002691	dimerization interface [polypeptide binding]; other site
414684002692	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
414684002693	DNA binding site [nucleotide binding]
414684002694	HAMP domain; Region: HAMP; pfam00672
414684002695	dimerization interface [polypeptide binding]; other site
414684002696	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684002697	dimer interface [polypeptide binding]; other site
414684002698	phosphorylation site [posttranslational modification]
414684002699	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684002700	ATP binding site [chemical binding]; other site
414684002701	Mg2+ binding site [ion binding]; other site
414684002702	G-X-G motif; other site
414684002703	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
414684002704	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
414684002705	metal binding site [ion binding]; metal-binding site
414684002706	putative dimer interface [polypeptide binding]; other site
414684002707	PrcB C-terminal; Region: PrcB_C; pfam14343
414684002708	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
414684002709	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
414684002710	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
414684002711	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
414684002712	ligand binding site [chemical binding]; other site
414684002713	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
414684002714	Predicted membrane protein [Function unknown]; Region: COG1238
414684002715	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
414684002716	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
414684002717	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
414684002718	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
414684002719	Protein export membrane protein; Region: SecD_SecF; pfam02355
414684002720	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
414684002721	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
414684002722	DNA binding residues [nucleotide binding]
414684002723	dimer interface [polypeptide binding]; other site
414684002724	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
414684002725	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
414684002726	active site
414684002727	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
414684002728	substrate binding site [chemical binding]; other site
414684002729	catalytic residues [active]
414684002730	dimer interface [polypeptide binding]; other site
414684002731	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317
414684002732	Cysteine-rich motif following a subset of SET domains; Region: PostSET; smart00508
414684002733	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
414684002734	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
414684002735	FAD binding site [chemical binding]; other site
414684002736	substrate binding site [chemical binding]; other site
414684002737	catalytic base [active]
414684002738	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
414684002739	putative catalytic site [active]
414684002740	putative metal binding site [ion binding]; other site
414684002741	putative phosphate binding site [ion binding]; other site
414684002742	Uncharacterized conserved protein [Function unknown]; Region: COG3791
414684002743	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
414684002744	putative catalytic site [active]
414684002745	putative phosphate binding site [ion binding]; other site
414684002746	active site
414684002747	metal binding site A [ion binding]; metal-binding site
414684002748	DNA binding site [nucleotide binding]
414684002749	putative AP binding site [nucleotide binding]; other site
414684002750	putative metal binding site B [ion binding]; other site
414684002751	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
414684002752	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
414684002753	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
414684002754	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
414684002755	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
414684002756	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
414684002757	active site
414684002758	HIGH motif; other site
414684002759	KMSK motif region; other site
414684002760	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
414684002761	tRNA binding surface [nucleotide binding]; other site
414684002762	anticodon binding site; other site
414684002763	Sporulation related domain; Region: SPOR; pfam05036
414684002764	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
414684002765	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
414684002766	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
414684002767	Peptidase family M50; Region: Peptidase_M50; pfam02163
414684002768	active site
414684002769	putative substrate binding region [chemical binding]; other site
414684002770	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
414684002771	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
414684002772	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
414684002773	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
414684002774	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
414684002775	seryl-tRNA synthetase; Provisional; Region: PRK05431
414684002776	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
414684002777	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
414684002778	dimer interface [polypeptide binding]; other site
414684002779	active site
414684002780	motif 1; other site
414684002781	motif 2; other site
414684002782	motif 3; other site
414684002783	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
414684002784	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
414684002785	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684002786	S-adenosylmethionine binding site [chemical binding]; other site
414684002787	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
414684002788	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
414684002789	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
414684002790	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
414684002791	Peptidase family M23; Region: Peptidase_M23; pfam01551
414684002792	Domain of unknown function DUF1828; Region: DUF1828; pfam08861
414684002793	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
414684002794	Protein of unknown function (DUF815); Region: DUF815; pfam05673
414684002795	Preprotein translocase subunit; Region: YajC; pfam02699
414684002796	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
414684002797	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
414684002798	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
414684002799	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
414684002800	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
414684002801	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
414684002802	substrate binding pocket [chemical binding]; other site
414684002803	substrate-Mg2+ binding site; other site
414684002804	aspartate-rich region 1; other site
414684002805	aspartate-rich region 2; other site
414684002806	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
414684002807	active site lid residues [active]
414684002808	catalytic residues [active]
414684002809	substrate binding pocket [chemical binding]; other site
414684002810	substrate-Mg2+ binding site; other site
414684002811	aspartate-rich region 1; other site
414684002812	aspartate-rich region 2; other site
414684002813	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
414684002814	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
414684002815	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
414684002816	Squalene/phytoene synthase; Region: SQS_PSY; pfam00494
414684002817	substrate binding pocket [chemical binding]; other site
414684002818	substrate-Mg2+ binding site; other site
414684002819	aspartate-rich region 1; other site
414684002820	aspartate-rich region 2; other site
414684002821	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
414684002822	Glucose inhibited division protein A; Region: GIDA; pfam01134
414684002823	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
414684002824	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
414684002825	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
414684002826	dimerization interface [polypeptide binding]; other site
414684002827	ligand binding site [chemical binding]; other site
414684002828	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
414684002829	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
414684002830	dimerization interface [polypeptide binding]; other site
414684002831	ligand binding site [chemical binding]; other site
414684002832	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
414684002833	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
414684002834	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
414684002835	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
414684002836	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
414684002837	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
414684002838	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
414684002839	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
414684002840	dimer interface [polypeptide binding]; other site
414684002841	ssDNA binding site [nucleotide binding]; other site
414684002842	tetramer (dimer of dimers) interface [polypeptide binding]; other site
414684002843	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
414684002844	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
414684002845	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
414684002846	cation binding site [ion binding]; other site
414684002847	DNA gyrase subunit A; Validated; Region: PRK05560
414684002848	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
414684002849	CAP-like domain; other site
414684002850	active site
414684002851	primary dimer interface [polypeptide binding]; other site
414684002852	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
414684002853	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
414684002854	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
414684002855	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
414684002856	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
414684002857	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
414684002858	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
414684002859	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
414684002860	active site
414684002861	(T/H)XGH motif; other site
414684002862	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
414684002863	Sel1-like repeats; Region: SEL1; smart00671
414684002864	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
414684002865	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
414684002866	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
414684002867	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
414684002868	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
414684002869	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
414684002870	Walker A/P-loop; other site
414684002871	ATP binding site [chemical binding]; other site
414684002872	Q-loop/lid; other site
414684002873	ABC transporter signature motif; other site
414684002874	Walker B; other site
414684002875	D-loop; other site
414684002876	H-loop/switch region; other site
414684002877	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
414684002878	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
414684002879	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
414684002880	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
414684002881	putative MPT binding site; other site
414684002882	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
414684002883	Ligand binding site; other site
414684002884	metal-binding site
414684002885	XdhC;part of the CO oxidising (Cox) system operon.possibly involved in the attachment of molybdenum to CO Dehydrogenase identified by match to protein family HMM PF01554 match to protein family HMM TIGR00797
414684002886	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
414684002887	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
414684002888	metal ion-dependent adhesion site (MIDAS); other site
414684002889	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
414684002890	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
414684002891	Walker A motif; other site
414684002892	ATP binding site [chemical binding]; other site
414684002893	Walker B motif; other site
414684002894	arginine finger; other site
414684002895	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
414684002896	FAD binding domain; Region: FAD_binding_4; pfam01565
414684002897	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
414684002898	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
414684002899	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
414684002900	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
414684002901	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
414684002902	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
414684002903	catalytic loop [active]
414684002904	iron binding site [ion binding]; other site
414684002905	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
414684002906	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
414684002907	putative hydrophobic ligand binding site [chemical binding]; other site
414684002908	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
414684002909	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
414684002910	transmembrane helices; other site
414684002911	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
414684002912	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
414684002913	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684002914	S-adenosylmethionine binding site [chemical binding]; other site
414684002915	EamA-like transporter family; Region: EamA; pfam00892
414684002916	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
414684002917	Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693
414684002918	Winged helix-turn helix; Region: HTH_29; pfam13551
414684002919	Integrase core domain; Region: rve; pfam00665
414684002920	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
414684002921	AAA domain; Region: AAA_22; pfam13401
414684002922	phage-related chromosomal replication initiator protein, pseudogene;part of the putative prophage RcenMu genome
414684002923	Protein of unknown function (DUF3164); Region: DUF3164; pfam11363
414684002924	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
414684002925	Protein of unknown function (DUF1018); Region: DUF1018; pfam06252
414684002926	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
414684002927	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
414684002928	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
414684002929	Protein of unknown function (DUF3486); Region: DUF3486; pfam11985
414684002930	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
414684002931	Protein of unknown function (DUF935); Region: DUF935; pfam06074
414684002932	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
414684002933	Glycerate kinase family; Region: Gly_kinase; cl00841
414684002934	Protein of unknown function (DUF1320); Region: DUF1320; pfam07030
414684002935	Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069
414684002936	Gp37 protein; Region: Gp37; pfam09646
414684002937	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
414684002938	Phage tail tube protein FII; Region: Phage_tube; pfam04985
414684002939	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
414684002940	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
414684002941	Phage P2 GpU; Region: Phage_P2_GpU; cl01391
414684002942	Phage Tail Protein X; Region: Phage_tail_X; cl02088
414684002943	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
414684002944	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
414684002945	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
414684002946	Baseplate J-like protein; Region: Baseplate_J; cl01294
414684002947	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684
414684002948	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
414684002949	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
414684002950	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
414684002951	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
414684002952	putative active site [active]
414684002953	putative NTP binding site [chemical binding]; other site
414684002954	putative nucleic acid binding site [nucleotide binding]; other site
414684002955	Predicted ATPase [General function prediction only]; Region: COG5293
414684002956	Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088
414684002957	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
414684002958	non-specific DNA binding site [nucleotide binding]; other site
414684002959	salt bridge; other site
414684002960	sequence-specific DNA binding site [nucleotide binding]; other site
414684002961	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
414684002962	cystathionine beta-lyase, bacterial; Region: cysta_beta_ly_B; TIGR01324
414684002963	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
414684002964	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
414684002965	catalytic residue [active]
414684002966	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
414684002967	3-mercaptopyruvate sulfurtransferase; Region: PLN02723
414684002968	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
414684002969	active site residue [active]
414684002970	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
414684002971	active site residue [active]
414684002972	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
414684002973	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
414684002974	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
414684002975	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
414684002976	dimer interface [polypeptide binding]; other site
414684002977	ADP-ribose binding site [chemical binding]; other site
414684002978	active site
414684002979	nudix motif; other site
414684002980	metal binding site [ion binding]; metal-binding site
414684002981	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
414684002982	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
414684002983	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
414684002984	dimer interface [polypeptide binding]; other site
414684002985	active site
414684002986	ADP-ribose binding site [chemical binding]; other site
414684002987	nudix motif; other site
414684002988	metal binding site [ion binding]; metal-binding site
414684002989	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
414684002990	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
414684002991	Methyltransferase domain; Region: Methyltransf_18; pfam12847
414684002992	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
414684002993	active site residue [active]
414684002994	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
414684002995	Protein of unknown function (DUF2497); Region: DUF2497; pfam10691
414684002996	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
414684002997	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
414684002998	HIGH motif; other site
414684002999	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
414684003000	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
414684003001	active site
414684003002	KMSKS motif; other site
414684003003	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
414684003004	tRNA binding surface [nucleotide binding]; other site
414684003005	anticodon binding site; other site
414684003006	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
414684003007	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
414684003008	Uncharacterized conserved protein [Function unknown]; Region: COG1434
414684003009	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
414684003010	putative active site [active]
414684003011	Transglycosylase SLT domain; Region: SLT_2; pfam13406
414684003012	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
414684003013	N-acetyl-D-glucosamine binding site [chemical binding]; other site
414684003014	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
414684003015	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
414684003016	Sporulation related domain; Region: SPOR; pfam05036
414684003017	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
414684003018	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
414684003019	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
414684003020	DNA polymerase III subunit delta'; Validated; Region: PRK07471
414684003021	DNA polymerase III subunit delta'; Validated; Region: PRK08485
414684003022	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
414684003023	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
414684003024	active site
414684003025	HIGH motif; other site
414684003026	KMSKS motif; other site
414684003027	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
414684003028	tRNA binding surface [nucleotide binding]; other site
414684003029	anticodon binding site; other site
414684003030	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
414684003031	active site
414684003032	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
414684003033	putative hydrolase; Provisional; Region: PRK02113
414684003034	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
414684003035	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684003036	dimer interface [polypeptide binding]; other site
414684003037	phosphorylation site [posttranslational modification]
414684003038	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684003039	ATP binding site [chemical binding]; other site
414684003040	Mg2+ binding site [ion binding]; other site
414684003041	G-X-G motif; other site
414684003042	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684003043	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
414684003044	active site
414684003045	phosphorylation site [posttranslational modification]
414684003046	intermolecular recognition site; other site
414684003047	dimerization interface [polypeptide binding]; other site
414684003048	circadian clock protein KaiC; Reviewed; Region: PRK09302
414684003049	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
414684003050	Walker A motif; other site
414684003051	ATP binding site [chemical binding]; other site
414684003052	Walker B motif; other site
414684003053	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
414684003054	Walker A motif; other site
414684003055	ATP binding site [chemical binding]; other site
414684003056	Walker B motif; other site
414684003057	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
414684003058	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
414684003059	N-terminal plug; other site
414684003060	ligand-binding site [chemical binding]; other site
414684003061	Predicted transcriptional regulators [Transcription]; Region: COG1733
414684003062	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
414684003063	Predicted transcriptional regulators [Transcription]; Region: COG1733
414684003064	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
414684003065	HAMP domain; Region: HAMP; pfam00672
414684003066	dimerization interface [polypeptide binding]; other site
414684003067	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684003068	dimer interface [polypeptide binding]; other site
414684003069	putative CheW interface [polypeptide binding]; other site
414684003070	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
414684003071	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
414684003072	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
414684003073	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
414684003074	metal binding site [ion binding]; metal-binding site
414684003075	active site
414684003076	I-site; other site
414684003077	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
414684003078	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
414684003079	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
414684003080	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
414684003081	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
414684003082	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
414684003083	Transposase [DNA replication, recombination, and repair]; Region: COG5433
414684003084	hypothetical protein; Provisional; Region: PRK09126
414684003085	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
414684003086	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
414684003087	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
414684003088	N-terminal plug; other site
414684003089	ligand-binding site [chemical binding]; other site
414684003090	Transcriptional regulator [Transcription]; Region: LysR; COG0583
414684003091	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
414684003092	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
414684003093	dimerization interface [polypeptide binding]; other site
414684003094	NADH dehydrogenase subunit L; Provisional; Region: PRK08168
414684003095	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
414684003096	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
414684003097	LexA repressor; Validated; Region: PRK00215
414684003098	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
414684003099	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
414684003100	Catalytic site [active]
414684003101	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
414684003102	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
414684003103	Competence protein; Region: Competence; pfam03772
414684003104	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
414684003105	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
414684003106	active site
414684003107	HIGH motif; other site
414684003108	nucleotide binding site [chemical binding]; other site
414684003109	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
414684003110	active site
414684003111	KMSKS motif; other site
414684003112	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
414684003113	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
414684003114	dimer interface [polypeptide binding]; other site
414684003115	active site
414684003116	citrylCoA binding site [chemical binding]; other site
414684003117	NADH binding [chemical binding]; other site
414684003118	cationic pore residues; other site
414684003119	oxalacetate/citrate binding site [chemical binding]; other site
414684003120	coenzyme A binding site [chemical binding]; other site
414684003121	catalytic triad [active]
414684003122	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
414684003123	dimer interface [polypeptide binding]; other site
414684003124	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
414684003125	ligand binding site [chemical binding]; other site
414684003126	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
414684003127	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
414684003128	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
414684003129	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
414684003130	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
414684003131	active site
414684003132	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
414684003133	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
414684003134	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
414684003135	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
414684003136	trimer interface [polypeptide binding]; other site
414684003137	active site
414684003138	UDP-GlcNAc binding site [chemical binding]; other site
414684003139	lipid binding site [chemical binding]; lipid-binding site
414684003140	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
414684003141	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
414684003142	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
414684003143	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
414684003144	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
414684003145	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
414684003146	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
414684003147	Surface antigen; Region: Bac_surface_Ag; pfam01103
414684003148	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
414684003149	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
414684003150	active site
414684003151	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
414684003152	protein binding site [polypeptide binding]; other site
414684003153	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
414684003154	putative substrate binding region [chemical binding]; other site
414684003155	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
414684003156	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
414684003157	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
414684003158	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
414684003159	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
414684003160	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
414684003161	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
414684003162	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
414684003163	catalytic residue [active]
414684003164	putative FPP diphosphate  binding site; other site
414684003165	putative FPP binding hydrophobic cleft; other site
414684003166	dimer interface [polypeptide binding]; other site
414684003167	putative IPP diphosphate binding site; other site
414684003168	ribosome recycling factor; Reviewed; Region: frr; PRK00083
414684003169	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
414684003170	hinge region; other site
414684003171	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
414684003172	putative nucleotide binding site [chemical binding]; other site
414684003173	uridine monophosphate binding site [chemical binding]; other site
414684003174	homohexameric interface [polypeptide binding]; other site
414684003175	elongation factor Ts; Provisional; Region: tsf; PRK09377
414684003176	UBA/TS-N domain; Region: UBA; pfam00627
414684003177	Elongation factor TS; Region: EF_TS; pfam00889
414684003178	Elongation factor TS; Region: EF_TS; pfam00889
414684003179	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
414684003180	rRNA interaction site [nucleotide binding]; other site
414684003181	S8 interaction site; other site
414684003182	putative laminin-1 binding site; other site
414684003183	Chorismate lyase; Region: Chor_lyase; cl01230
414684003184	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
414684003185	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
414684003186	putative active site [active]
414684003187	putative PHP Thumb interface [polypeptide binding]; other site
414684003188	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
414684003189	generic binding surface II; other site
414684003190	generic binding surface I; other site
414684003191	EamA-like transporter family; Region: EamA; pfam00892
414684003192	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
414684003193	EamA-like transporter family; Region: EamA; pfam00892
414684003194	DNA-3-methyladenine glycosylase, pseudogene;identified by match to protein family HMM PF03938
414684003195	DNA-3-methyladenine glycosidase II, pseudogene;identified by match to protein family HMM PF01103 match to protein family HMM PF07244
414684003196	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
414684003197	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
414684003198	Walker A/P-loop; other site
414684003199	ATP binding site [chemical binding]; other site
414684003200	Q-loop/lid; other site
414684003201	ABC transporter signature motif; other site
414684003202	Walker B; other site
414684003203	D-loop; other site
414684003204	H-loop/switch region; other site
414684003205	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
414684003206	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
414684003207	FtsX-like permease family; Region: FtsX; pfam02687
414684003208	prolyl-tRNA synthetase; Provisional; Region: PRK12325
414684003209	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
414684003210	dimer interface [polypeptide binding]; other site
414684003211	motif 1; other site
414684003212	active site
414684003213	motif 2; other site
414684003214	motif 3; other site
414684003215	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
414684003216	anticodon binding site; other site
414684003217	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
414684003218	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
414684003219	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
414684003220	Protein of unknown function (DUF1467); Region: DUF1467; pfam07330
414684003221	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
414684003222	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
414684003223	dimer interface [polypeptide binding]; other site
414684003224	substrate binding site [chemical binding]; other site
414684003225	metal binding site [ion binding]; metal-binding site
414684003226	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
414684003227	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
414684003228	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
414684003229	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
414684003230	nucleotide binding site [chemical binding]; other site
414684003231	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
414684003232	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
414684003233	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
414684003234	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
414684003235	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
414684003236	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
414684003237	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
414684003238	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
414684003239	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
414684003240	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
414684003241	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
414684003242	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
414684003243	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
414684003244	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
414684003245	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
414684003246	4Fe-4S binding domain; Region: Fer4; pfam00037
414684003247	4Fe-4S binding domain; Region: Fer4; pfam00037
414684003248	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
414684003249	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
414684003250	NADH dehydrogenase subunit G; Validated; Region: PRK09130
414684003251	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
414684003252	catalytic loop [active]
414684003253	iron binding site [ion binding]; other site
414684003254	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
414684003255	MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773
414684003256	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
414684003257	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
414684003258	SLBB domain; Region: SLBB; pfam10531
414684003259	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
414684003260	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
414684003261	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
414684003262	putative dimer interface [polypeptide binding]; other site
414684003263	[2Fe-2S] cluster binding site [ion binding]; other site
414684003264	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
414684003265	NADH dehydrogenase subunit D; Validated; Region: PRK06075
414684003266	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
414684003267	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
414684003268	NADH dehydrogenase subunit B; Validated; Region: PRK06411
414684003269	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
414684003270	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
414684003271	IHF dimer interface [polypeptide binding]; other site
414684003272	IHF - DNA interface [nucleotide binding]; other site
414684003273	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
414684003274	Found in ATP-dependent protease La (LON); Region: LON; smart00464
414684003275	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
414684003276	Walker A motif; other site
414684003277	ATP binding site [chemical binding]; other site
414684003278	Walker B motif; other site
414684003279	arginine finger; other site
414684003280	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
414684003281	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
414684003282	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
414684003283	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
414684003284	Walker A motif; other site
414684003285	ATP binding site [chemical binding]; other site
414684003286	Walker B motif; other site
414684003287	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
414684003288	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
414684003289	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
414684003290	oligomer interface [polypeptide binding]; other site
414684003291	active site residues [active]
414684003292	trigger factor; Provisional; Region: tig; PRK01490
414684003293	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
414684003294	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
414684003295	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
414684003296	TPP-binding site [chemical binding]; other site
414684003297	PYR/PP interface [polypeptide binding]; other site
414684003298	dimer interface [polypeptide binding]; other site
414684003299	TPP binding site [chemical binding]; other site
414684003300	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
414684003301	Uncharacterized conserved protein [Function unknown]; Region: COG0062
414684003302	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
414684003303	putative substrate binding site [chemical binding]; other site
414684003304	putative ATP binding site [chemical binding]; other site
414684003305	Domain of unknown function (DUF897); Region: DUF897; cl01312
414684003306	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
414684003307	Nitrogen regulatory protein P-II; Region: P-II; smart00938
414684003308	glutamine synthetase; Provisional; Region: glnA; PRK09469
414684003309	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
414684003310	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
414684003311	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
414684003312	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
414684003313	catalytic residues [active]
414684003314	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
414684003315	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
414684003316	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
414684003317	ATP binding site [chemical binding]; other site
414684003318	putative Mg++ binding site [ion binding]; other site
414684003319	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
414684003320	nucleotide binding region [chemical binding]; other site
414684003321	ATP-binding site [chemical binding]; other site
414684003322	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
414684003323	Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937
414684003324	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
414684003325	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
414684003326	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
414684003327	Transposase [DNA replication, recombination, and repair]; Region: COG5433
414684003328	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
414684003329	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
414684003330	generic binding surface II; other site
414684003331	ssDNA binding site; other site
414684003332	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
414684003333	ATP binding site [chemical binding]; other site
414684003334	putative Mg++ binding site [ion binding]; other site
414684003335	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
414684003336	nucleotide binding region [chemical binding]; other site
414684003337	ATP-binding site [chemical binding]; other site
414684003338	Uncharacterized conserved protein [Function unknown]; Region: COG2928
414684003339	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
414684003340	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
414684003341	malonyl-CoA binding site [chemical binding]; other site
414684003342	dimer interface [polypeptide binding]; other site
414684003343	active site
414684003344	product binding site; other site
414684003345	Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; pfam04140
414684003346	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
414684003347	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
414684003348	ligand binding site [chemical binding]; other site
414684003349	flexible hinge region; other site
414684003350	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
414684003351	putative switch regulator; other site
414684003352	non-specific DNA interactions [nucleotide binding]; other site
414684003353	DNA binding site [nucleotide binding]
414684003354	sequence specific DNA binding site [nucleotide binding]; other site
414684003355	putative cAMP binding site [chemical binding]; other site
414684003356	Transcriptional regulator; Region: CitT; pfam12431
414684003357	flagellar motor switch protein FliN; Region: fliN; TIGR02480
414684003358	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
414684003359	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
414684003360	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
414684003361	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
414684003362	metal-binding site [ion binding]
414684003363	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
414684003364	Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456
414684003365	FixH; Region: FixH; pfam05751
414684003366	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
414684003367	4Fe-4S binding domain; Region: Fer4_5; pfam12801
414684003368	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
414684003369	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
414684003370	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
414684003371	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
414684003372	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
414684003373	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433
414684003374	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
414684003375	Low-spin heme binding site [chemical binding]; other site
414684003376	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
414684003377	Putative water exit pathway; other site
414684003378	Binuclear center (active site) [active]
414684003379	Putative proton exit pathway; other site
414684003380	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
414684003381	Family description; Region: DsbD_2; pfam13386
414684003382	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
414684003383	Phage integrase family; Region: Phage_integrase; pfam00589
414684003384	active site
414684003385	DNA binding site [nucleotide binding]
414684003386	Int/Topo IB signature motif; other site
414684003387	phage-related conserved hypothetical protein, pseudogene;identified by match to protein family HMM PF03597 match to protein family HMM TIGR00847
414684003388	Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720
414684003389	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
414684003390	Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136
414684003391	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
414684003392	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
414684003393	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
414684003394	Uncharacterized conserved protein (DUF2190); Region: DUF2190; pfam09956
414684003395	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
414684003396	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
414684003397	non-specific DNA binding site [nucleotide binding]; other site
414684003398	salt bridge; other site
414684003399	sequence-specific DNA binding site [nucleotide binding]; other site
414684003400	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
414684003401	DHH family; Region: DHH; pfam01368
414684003402	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
414684003403	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
414684003404	putative active site [active]
414684003405	homoserine dehydrogenase; Provisional; Region: PRK06349
414684003406	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
414684003407	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
414684003408	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
414684003409	aminotransferase; Validated; Region: PRK09148
414684003410	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
414684003411	pyridoxal 5'-phosphate binding site [chemical binding]; other site
414684003412	homodimer interface [polypeptide binding]; other site
414684003413	catalytic residue [active]
414684003414	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
414684003415	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
414684003416	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
414684003417	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
414684003418	trimer interface [polypeptide binding]; other site
414684003419	putative metal binding site [ion binding]; other site
414684003420	Domain of unknown function DUF29; Region: DUF29; pfam01724
414684003421	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
414684003422	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
414684003423	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
414684003424	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
414684003425	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
414684003426	23S rRNA interface [nucleotide binding]; other site
414684003427	L3 interface [polypeptide binding]; other site
414684003428	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
414684003429	CoenzymeA binding site [chemical binding]; other site
414684003430	subunit interaction site [polypeptide binding]; other site
414684003431	PHB binding site; other site
414684003432	enoyl-CoA hydratase; Validated; Region: PRK08139
414684003433	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
414684003434	substrate binding site [chemical binding]; other site
414684003435	oxyanion hole (OAH) forming residues; other site
414684003436	trimer interface [polypeptide binding]; other site
414684003437	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
414684003438	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994
414684003439	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
414684003440	homodimer interface [polypeptide binding]; other site
414684003441	substrate-cofactor binding pocket; other site
414684003442	pyridoxal 5'-phosphate binding site [chemical binding]; other site
414684003443	catalytic residue [active]
414684003444	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
414684003445	putative substrate translocation pore; other site
414684003446	Major Facilitator Superfamily; Region: MFS_1; pfam07690
414684003447	CutA1 divalent ion tolerance protein; Region: CutA1; pfam03091
414684003448	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
414684003449	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
414684003450	DNA binding residues [nucleotide binding]
414684003451	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
414684003452	IHF dimer interface [polypeptide binding]; other site
414684003453	IHF - DNA interface [nucleotide binding]; other site
414684003454	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
414684003455	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
414684003456	dimer interface [polypeptide binding]; other site
414684003457	active site
414684003458	CoA binding pocket [chemical binding]; other site
414684003459	putative phosphate acyltransferase; Provisional; Region: PRK05331
414684003460	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
414684003461	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
414684003462	Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; pfam03981
414684003463	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
414684003464	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
414684003465	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
414684003466	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
414684003467	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
414684003468	thiamine monophosphate kinase; Provisional; Region: PRK05731
414684003469	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
414684003470	ATP binding site [chemical binding]; other site
414684003471	dimerization interface [polypeptide binding]; other site
414684003472	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
414684003473	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
414684003474	homopentamer interface [polypeptide binding]; other site
414684003475	active site
414684003476	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
414684003477	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
414684003478	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
414684003479	dimerization interface [polypeptide binding]; other site
414684003480	active site
414684003481	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
414684003482	Lumazine binding domain; Region: Lum_binding; pfam00677
414684003483	Lumazine binding domain; Region: Lum_binding; pfam00677
414684003484	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
414684003485	catalytic motif [active]
414684003486	Zn binding site [ion binding]; other site
414684003487	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
414684003488	RibD C-terminal domain; Region: RibD_C; cl17279
414684003489	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
414684003490	Restriction alleviation protein Lar; Region: Lar_restr_allev; cl08047
414684003491	ATP cone domain; Region: ATP-cone; pfam03477
414684003492	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
414684003493	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
414684003494	dimer interface [polypeptide binding]; other site
414684003495	active site
414684003496	glycine-pyridoxal phosphate binding site [chemical binding]; other site
414684003497	folate binding site [chemical binding]; other site
414684003498	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
414684003499	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
414684003500	Transcriptional regulators [Transcription]; Region: MarR; COG1846
414684003501	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
414684003502	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
414684003503	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
414684003504	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
414684003505	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
414684003506	substrate binding site [chemical binding]; other site
414684003507	oxyanion hole (OAH) forming residues; other site
414684003508	trimer interface [polypeptide binding]; other site
414684003509	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
414684003510	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
414684003511	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
414684003512	substrate binding pocket [chemical binding]; other site
414684003513	FAD binding site [chemical binding]; other site
414684003514	catalytic base [active]
414684003515	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
414684003516	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
414684003517	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
414684003518	putative active site [active]
414684003519	putative metal binding site [ion binding]; other site
414684003520	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
414684003521	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
414684003522	dimer interface [polypeptide binding]; other site
414684003523	allosteric magnesium binding site [ion binding]; other site
414684003524	active site
414684003525	aspartate-rich active site metal binding site; other site
414684003526	Schiff base residues; other site
414684003527	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
414684003528	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
414684003529	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
414684003530	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
414684003531	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
414684003532	dimer interface [polypeptide binding]; other site
414684003533	active site
414684003534	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
414684003535	catalytic residues [active]
414684003536	substrate binding site [chemical binding]; other site
414684003537	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
414684003538	Magnetospirillum NAD(P)+-dependent aldehyde dehydrogenase MSR-1-like; Region: ALDH_MGR_2402; cd07108
414684003539	NAD(P) binding site [chemical binding]; other site
414684003540	catalytic residues [active]
414684003541	catalytic residues [active]
414684003542	Penicillin amidase; Region: Penicil_amidase; pfam01804
414684003543	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
414684003544	active site
414684003545	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
414684003546	flagellar motor protein MotB; Reviewed; Region: motB; PRK08944
414684003547	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
414684003548	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
414684003549	ligand binding site [chemical binding]; other site
414684003550	Uncharacterized conserved protein [Function unknown]; Region: COG2308
414684003551	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
414684003552	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
414684003553	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
414684003554	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
414684003555	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
414684003556	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
414684003557	Cytochrome c; Region: Cytochrom_C; pfam00034
414684003558	Response regulator receiver domain; Region: Response_reg; pfam00072
414684003559	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684003560	active site
414684003561	phosphorylation site [posttranslational modification]
414684003562	intermolecular recognition site; other site
414684003563	dimerization interface [polypeptide binding]; other site
414684003564	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
414684003565	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
414684003566	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684003567	ATP binding site [chemical binding]; other site
414684003568	Mg2+ binding site [ion binding]; other site
414684003569	G-X-G motif; other site
414684003570	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
414684003571	anchoring element; other site
414684003572	dimer interface [polypeptide binding]; other site
414684003573	ATP binding site [chemical binding]; other site
414684003574	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
414684003575	active site
414684003576	putative metal-binding site [ion binding]; other site
414684003577	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
414684003578	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
414684003579	Isochorismatase family; Region: Isochorismatase; pfam00857
414684003580	catalytic triad [active]
414684003581	dimer interface [polypeptide binding]; other site
414684003582	conserved cis-peptide bond; other site
414684003583	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
414684003584	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
414684003585	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
414684003586	ATP binding site [chemical binding]; other site
414684003587	Mg++ binding site [ion binding]; other site
414684003588	motif III; other site
414684003589	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
414684003590	nucleotide binding region [chemical binding]; other site
414684003591	ATP-binding site [chemical binding]; other site
414684003592	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
414684003593	AsnC family; Region: AsnC_trans_reg; pfam01037
414684003594	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
414684003595	OstA-like protein; Region: OstA; cl00844
414684003596	Organic solvent tolerance protein; Region: OstA_C; pfam04453
414684003597	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
414684003598	catalytic residues [active]
414684003599	dimer interface [polypeptide binding]; other site
414684003600	Protein of unknown function (DUF904); Region: DUF904; cl11531
414684003601	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
414684003602	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
414684003603	putative active site [active]
414684003604	metal binding site [ion binding]; metal-binding site
414684003605	Protein of unknown function (DUF1318); Region: DUF1318; pfam07027
414684003606	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
414684003607	Dicarboxylate transport; Region: DctA-YdbH; pfam11739
414684003608	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
414684003609	active site
414684003610	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
414684003611	active site
414684003612	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12689
414684003613	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
414684003614	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
414684003615	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691
414684003616	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
414684003617	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
414684003618	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK12786
414684003619	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
414684003620	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
414684003621	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
414684003622	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
414684003623	flagellar assembly regulator FliX; Reviewed; Region: fliX; PRK12787
414684003624	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
414684003625	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
414684003626	Rod binding protein; Region: Rod-binding; cl01626
414684003627	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
414684003628	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
414684003629	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
414684003630	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
414684003631	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
414684003632	GTP-binding protein Der; Reviewed; Region: PRK00093
414684003633	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
414684003634	G1 box; other site
414684003635	GTP/Mg2+ binding site [chemical binding]; other site
414684003636	Switch I region; other site
414684003637	G2 box; other site
414684003638	Switch II region; other site
414684003639	G3 box; other site
414684003640	G4 box; other site
414684003641	G5 box; other site
414684003642	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
414684003643	G1 box; other site
414684003644	GTP/Mg2+ binding site [chemical binding]; other site
414684003645	Switch I region; other site
414684003646	G2 box; other site
414684003647	G3 box; other site
414684003648	Switch II region; other site
414684003649	G4 box; other site
414684003650	G5 box; other site
414684003651	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
414684003652	Trp docking motif [polypeptide binding]; other site
414684003653	active site
414684003654	PQQ-like domain; Region: PQQ_2; pfam13360
414684003655	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
414684003656	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
414684003657	putative catalytic residue [active]
414684003658	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
414684003659	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
414684003660	active site
414684003661	phosphorylation site [posttranslational modification]
414684003662	intermolecular recognition site; other site
414684003663	dimerization interface [polypeptide binding]; other site
414684003664	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
414684003665	DNA binding residues [nucleotide binding]
414684003666	dimerization interface [polypeptide binding]; other site
414684003667	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
414684003668	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
414684003669	DNA binding residues [nucleotide binding]
414684003670	dimerization interface [polypeptide binding]; other site
414684003671	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684003672	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
414684003673	active site
414684003674	phosphorylation site [posttranslational modification]
414684003675	intermolecular recognition site; other site
414684003676	dimerization interface [polypeptide binding]; other site
414684003677	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
414684003678	DNA binding residues [nucleotide binding]
414684003679	dimerization interface [polypeptide binding]; other site
414684003680	AAA ATPase domain; Region: AAA_16; pfam13191
414684003681	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
414684003682	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
414684003683	SLBB domain; Region: SLBB; pfam10531
414684003684	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
414684003685	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
414684003686	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
414684003687	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
414684003688	active site
414684003689	AAA domain; Region: AAA_22; pfam13401
414684003690	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
414684003691	TPR motif; other site
414684003692	binding surface
414684003693	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
414684003694	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
414684003695	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
414684003696	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
414684003697	hydrogenase 4 subunit F; Validated; Region: PRK06458
414684003698	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
414684003699	Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899
414684003700	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
414684003701	NADH dehydrogenase; Region: NADHdh; cl00469
414684003702	hydrogenase 4 subunit B; Validated; Region: PRK06521
414684003703	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
414684003704	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
414684003705	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
414684003706	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
414684003707	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
414684003708	RNA binding site [nucleotide binding]; other site
414684003709	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
414684003710	catalytic nucleophile [active]
414684003711	Response regulator receiver domain; Region: Response_reg; pfam00072
414684003712	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684003713	active site
414684003714	phosphorylation site [posttranslational modification]
414684003715	intermolecular recognition site; other site
414684003716	dimerization interface [polypeptide binding]; other site
414684003717	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684003718	S-adenosylmethionine binding site [chemical binding]; other site
414684003719	Predicted transcriptional regulators [Transcription]; Region: COG1695
414684003720	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
414684003721	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
414684003722	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
414684003723	HlyD family secretion protein; Region: HlyD_3; pfam13437
414684003724	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
414684003725	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
414684003726	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
414684003727	CDP-alcohol phosphatidyltransferase 2; Region: CDP-OH_P_tran_2; pfam08009
414684003728	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
414684003729	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684003730	Response regulator receiver domain; Region: Response_reg; pfam00072
414684003731	active site
414684003732	phosphorylation site [posttranslational modification]
414684003733	intermolecular recognition site; other site
414684003734	dimerization interface [polypeptide binding]; other site
414684003735	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330
414684003736	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
414684003737	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
414684003738	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
414684003739	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
414684003740	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
414684003741	ATP binding site [chemical binding]; other site
414684003742	putative Mg++ binding site [ion binding]; other site
414684003743	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
414684003744	nucleotide binding region [chemical binding]; other site
414684003745	ATP-binding site [chemical binding]; other site
414684003746	Helicase associated domain (HA2); Region: HA2; pfam04408
414684003747	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
414684003748	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
414684003749	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
414684003750	Protein of unknown function (DUF330); Region: DUF330; cl01135
414684003751	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
414684003752	mce related protein; Region: MCE; pfam02470
414684003753	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
414684003754	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
414684003755	Walker A/P-loop; other site
414684003756	ATP binding site [chemical binding]; other site
414684003757	Q-loop/lid; other site
414684003758	ABC transporter signature motif; other site
414684003759	Walker B; other site
414684003760	D-loop; other site
414684003761	H-loop/switch region; other site
414684003762	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
414684003763	anti sigma factor interaction site; other site
414684003764	regulatory phosphorylation site [posttranslational modification]; other site
414684003765	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
414684003766	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
414684003767	Permease; Region: Permease; pfam02405
414684003768	putative active site [active]
414684003769	catalytic site [active]
414684003770	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
414684003771	active site
414684003772	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
414684003773	dimer interface [polypeptide binding]; other site
414684003774	conserved gate region; other site
414684003775	putative PBP binding loops; other site
414684003776	ABC-ATPase subunit interface; other site
414684003777	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
414684003778	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
414684003779	Walker A/P-loop; other site
414684003780	ATP binding site [chemical binding]; other site
414684003781	Q-loop/lid; other site
414684003782	ABC transporter signature motif; other site
414684003783	Walker B; other site
414684003784	D-loop; other site
414684003785	H-loop/switch region; other site
414684003786	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
414684003787	short chain dehydrogenase; Provisional; Region: PRK09134
414684003788	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
414684003789	NAD(P) binding site [chemical binding]; other site
414684003790	active site
414684003791	Creatinine amidohydrolase; Region: Creatininase; pfam02633
414684003792	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
414684003793	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
414684003794	active site
414684003795	metal binding site [ion binding]; metal-binding site
414684003796	hexamer interface [polypeptide binding]; other site
414684003797	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
414684003798	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
414684003799	NAD(P) binding site [chemical binding]; other site
414684003800	catalytic residues [active]
414684003801	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
414684003802	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
414684003803	oligomer interface [polypeptide binding]; other site
414684003804	active site residues [active]
414684003805	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
414684003806	MOSC domain; Region: MOSC; pfam03473
414684003807	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
414684003808	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
414684003809	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
414684003810	agmatine deiminase; Region: agmatine_aguA; TIGR03380
414684003811	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
414684003812	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
414684003813	dimer interface [polypeptide binding]; other site
414684003814	conserved gate region; other site
414684003815	putative PBP binding loops; other site
414684003816	ABC-ATPase subunit interface; other site
414684003817	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
414684003818	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
414684003819	dimer interface [polypeptide binding]; other site
414684003820	conserved gate region; other site
414684003821	putative PBP binding loops; other site
414684003822	ABC-ATPase subunit interface; other site
414684003823	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
414684003824	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
414684003825	Walker A/P-loop; other site
414684003826	ATP binding site [chemical binding]; other site
414684003827	Q-loop/lid; other site
414684003828	ABC transporter signature motif; other site
414684003829	Walker B; other site
414684003830	D-loop; other site
414684003831	H-loop/switch region; other site
414684003832	TOBE domain; Region: TOBE_2; pfam08402
414684003833	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
414684003834	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
414684003835	putative aminotransferase; Validated; Region: PRK07480
414684003836	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
414684003837	inhibitor-cofactor binding pocket; inhibition site
414684003838	pyridoxal 5'-phosphate binding site [chemical binding]; other site
414684003839	catalytic residue [active]
414684003840	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
414684003841	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
414684003842	substrate binding site [chemical binding]; other site
414684003843	oxyanion hole (OAH) forming residues; other site
414684003844	trimer interface [polypeptide binding]; other site
414684003845	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684003846	dimer interface [polypeptide binding]; other site
414684003847	phosphorylation site [posttranslational modification]
414684003848	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684003849	ATP binding site [chemical binding]; other site
414684003850	Mg2+ binding site [ion binding]; other site
414684003851	G-X-G motif; other site
414684003852	Response regulator receiver domain; Region: Response_reg; pfam00072
414684003853	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684003854	active site
414684003855	phosphorylation site [posttranslational modification]
414684003856	intermolecular recognition site; other site
414684003857	dimerization interface [polypeptide binding]; other site
414684003858	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
414684003859	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
414684003860	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
414684003861	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
414684003862	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
414684003863	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
414684003864	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
414684003865	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
414684003866	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
414684003867	inhibitor-cofactor binding pocket; inhibition site
414684003868	pyridoxal 5'-phosphate binding site [chemical binding]; other site
414684003869	catalytic residue [active]
414684003870	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
414684003871	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
414684003872	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
414684003873	Histidine kinase; Region: HisKA_2; pfam07568
414684003874	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
414684003875	ATP binding site [chemical binding]; other site
414684003876	Mg2+ binding site [ion binding]; other site
414684003877	G-X-G motif; other site
414684003878	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
414684003879	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
414684003880	NAD(P) binding site [chemical binding]; other site
414684003881	homodimer interface [polypeptide binding]; other site
414684003882	substrate binding site [chemical binding]; other site
414684003883	active site
414684003884	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
414684003885	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
414684003886	thiamine pyrophosphate protein; Validated; Region: PRK08199
414684003887	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
414684003888	PYR/PP interface [polypeptide binding]; other site
414684003889	dimer interface [polypeptide binding]; other site
414684003890	TPP binding site [chemical binding]; other site
414684003891	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
414684003892	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
414684003893	TPP-binding site [chemical binding]; other site
414684003894	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
414684003895	C-terminal domain interface [polypeptide binding]; other site
414684003896	GSH binding site (G-site) [chemical binding]; other site
414684003897	dimer interface [polypeptide binding]; other site
414684003898	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
414684003899	N-terminal domain interface [polypeptide binding]; other site
414684003900	dimer interface [polypeptide binding]; other site
414684003901	substrate binding pocket (H-site) [chemical binding]; other site
414684003902	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
414684003903	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
414684003904	CAP-like domain; other site
414684003905	active site
414684003906	primary dimer interface [polypeptide binding]; other site
414684003907	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
414684003908	Recombination protein O N terminal; Region: RecO_N; pfam11967
414684003909	Recombination protein O C terminal; Region: RecO_C; pfam02565
414684003910	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684003911	PAS fold; Region: PAS_3; pfam08447
414684003912	putative active site [active]
414684003913	heme pocket [chemical binding]; other site
414684003914	Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316
414684003915	PAS fold; Region: PAS_3; pfam08447
414684003916	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
414684003917	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
414684003918	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
414684003919	metal binding site [ion binding]; metal-binding site
414684003920	active site
414684003921	I-site; other site
414684003922	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
414684003923	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
414684003924	GTPase Era; Reviewed; Region: era; PRK00089
414684003925	G1 box; other site
414684003926	GTP/Mg2+ binding site [chemical binding]; other site
414684003927	Switch I region; other site
414684003928	G2 box; other site
414684003929	Switch II region; other site
414684003930	G3 box; other site
414684003931	G4 box; other site
414684003932	G5 box; other site
414684003933	KH domain; Region: KH_2; pfam07650
414684003934	ribonuclease III; Reviewed; Region: rnc; PRK00102
414684003935	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
414684003936	dimerization interface [polypeptide binding]; other site
414684003937	active site
414684003938	metal binding site [ion binding]; metal-binding site
414684003939	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
414684003940	dsRNA binding site [nucleotide binding]; other site
414684003941	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
414684003942	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
414684003943	Catalytic site [active]
414684003944	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
414684003945	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
414684003946	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
414684003947	active site
414684003948	hydrophilic channel; other site
414684003949	dimerization interface [polypeptide binding]; other site
414684003950	catalytic residues [active]
414684003951	active site lid [active]
414684003952	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
414684003953	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
414684003954	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
414684003955	Zn2+ binding site [ion binding]; other site
414684003956	Mg2+ binding site [ion binding]; other site
414684003957	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
414684003958	synthetase active site [active]
414684003959	NTP binding site [chemical binding]; other site
414684003960	metal binding site [ion binding]; metal-binding site
414684003961	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
414684003962	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
414684003963	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
414684003964	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
414684003965	catalytic center binding site [active]
414684003966	ATP binding site [chemical binding]; other site
414684003967	Uncharacterized conserved protein [Function unknown]; Region: COG1432
414684003968	LabA_like proteins; Region: LabA; cd10911
414684003969	putative metal binding site [ion binding]; other site
414684003970	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
414684003971	Fe-S cluster binding site [ion binding]; other site
414684003972	DNA binding site [nucleotide binding]
414684003973	active site
414684003974	Protein of unknown function (DUF1036); Region: DUF1036; cl02296
414684003975	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
414684003976	SmpB-tmRNA interface; other site
414684003977	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
414684003978	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
414684003979	dimer interface [polypeptide binding]; other site
414684003980	active site
414684003981	catalytic residue [active]
414684003982	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
414684003983	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
414684003984	N-acetyl-D-glucosamine binding site [chemical binding]; other site
414684003985	catalytic residue [active]
414684003986	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
414684003987	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
414684003988	EamA-like transporter family; Region: EamA; pfam00892
414684003989	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
414684003990	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
414684003991	non-specific DNA binding site [nucleotide binding]; other site
414684003992	salt bridge; other site
414684003993	sequence-specific DNA binding site [nucleotide binding]; other site
414684003994	L-type amino acid transporter; Region: 2A0308; TIGR00911
414684003995	Methyltransferase domain; Region: Methyltransf_31; pfam13847
414684003996	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684003997	S-adenosylmethionine binding site [chemical binding]; other site
414684003998	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
414684003999	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
414684004000	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
414684004001	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
414684004002	Membrane transport protein; Region: Mem_trans; cl09117
414684004003	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
414684004004	CoA-transferase family III; Region: CoA_transf_3; pfam02515
414684004005	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
414684004006	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
414684004007	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
414684004008	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
414684004009	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
414684004010	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
414684004011	dihydroorotase; Validated; Region: PRK09059
414684004012	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
414684004013	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
414684004014	active site
414684004015	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
414684004016	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
414684004017	DNA protecting protein DprA; Region: dprA; TIGR00732
414684004018	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
414684004019	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
414684004020	active site
414684004021	interdomain interaction site; other site
414684004022	putative metal-binding site [ion binding]; other site
414684004023	nucleotide binding site [chemical binding]; other site
414684004024	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
414684004025	domain I; other site
414684004026	DNA binding groove [nucleotide binding]
414684004027	phosphate binding site [ion binding]; other site
414684004028	domain II; other site
414684004029	domain III; other site
414684004030	nucleotide binding site [chemical binding]; other site
414684004031	catalytic site [active]
414684004032	domain IV; other site
414684004033	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
414684004034	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
414684004035	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
414684004036	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
414684004037	ribonuclease R; Region: RNase_R; TIGR02063
414684004038	RNB domain; Region: RNB; pfam00773
414684004039	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
414684004040	RNA binding site [nucleotide binding]; other site
414684004041	C-terminal peptidase (prc); Region: prc; TIGR00225
414684004042	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
414684004043	protein binding site [polypeptide binding]; other site
414684004044	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
414684004045	Catalytic dyad [active]
414684004046	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
414684004047	response regulator PleD; Reviewed; Region: pleD; PRK09581
414684004048	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684004049	active site
414684004050	phosphorylation site [posttranslational modification]
414684004051	intermolecular recognition site; other site
414684004052	dimerization interface [polypeptide binding]; other site
414684004053	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684004054	active site
414684004055	phosphorylation site [posttranslational modification]
414684004056	intermolecular recognition site; other site
414684004057	dimerization interface [polypeptide binding]; other site
414684004058	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
414684004059	metal binding site [ion binding]; metal-binding site
414684004060	active site
414684004061	I-site; other site
414684004062	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
414684004063	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684004064	active site
414684004065	phosphorylation site [posttranslational modification]
414684004066	intermolecular recognition site; other site
414684004067	dimerization interface [polypeptide binding]; other site
414684004068	DNA polymerase IV; Provisional; Region: PRK02794
414684004069	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
414684004070	active site
414684004071	DNA binding site [nucleotide binding]
414684004072	Domain of unknown function (DUF1849); Region: DUF1849; pfam08904
414684004073	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
414684004074	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
414684004075	dimerization interface [polypeptide binding]; other site
414684004076	putative DNA binding site [nucleotide binding]; other site
414684004077	putative Zn2+ binding site [ion binding]; other site
414684004078	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
414684004079	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
414684004080	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
414684004081	metal binding site [ion binding]; metal-binding site
414684004082	active site
414684004083	I-site; other site
414684004084	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
414684004085	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
414684004086	dimer interface [polypeptide binding]; other site
414684004087	anticodon binding site; other site
414684004088	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
414684004089	homodimer interface [polypeptide binding]; other site
414684004090	motif 1; other site
414684004091	active site
414684004092	motif 2; other site
414684004093	GAD domain; Region: GAD; pfam02938
414684004094	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
414684004095	active site
414684004096	motif 3; other site
414684004097	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
414684004098	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
414684004099	catalytic site [active]
414684004100	putative active site [active]
414684004101	putative substrate binding site [chemical binding]; other site
414684004102	HRDC domain; Region: HRDC; pfam00570
414684004103	exopolyphosphatase; Region: exo_poly_only; TIGR03706
414684004104	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
414684004105	polyphosphate kinase; Provisional; Region: PRK05443
414684004106	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
414684004107	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
414684004108	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
414684004109	putative domain interface [polypeptide binding]; other site
414684004110	putative active site [active]
414684004111	catalytic site [active]
414684004112	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
414684004113	putative domain interface [polypeptide binding]; other site
414684004114	putative active site [active]
414684004115	catalytic site [active]
414684004116	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
414684004117	catalytic core [active]
414684004118	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
414684004119	putative active site [active]
414684004120	putative metal binding residues [ion binding]; other site
414684004121	signature motif; other site
414684004122	putative triphosphate binding site [ion binding]; other site
414684004123	CHAD domain; Region: CHAD; pfam05235
414684004124	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
414684004125	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
414684004126	Walker A motif; other site
414684004127	ATP binding site [chemical binding]; other site
414684004128	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
414684004129	Domain of unknown function DUF20; Region: UPF0118; pfam01594
414684004130	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
414684004131	Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839
414684004132	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
414684004133	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
414684004134	dimerization interface [polypeptide binding]; other site
414684004135	putative ATP binding site [chemical binding]; other site
414684004136	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
414684004137	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
414684004138	active site
414684004139	substrate binding site [chemical binding]; other site
414684004140	cosubstrate binding site; other site
414684004141	catalytic site [active]
414684004142	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
414684004143	active site
414684004144	multimer interface [polypeptide binding]; other site
414684004145	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
414684004146	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
414684004147	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
414684004148	ABC transporter; Region: ABC_tran_2; pfam12848
414684004149	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
414684004150	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
414684004151	short chain dehydrogenase; Provisional; Region: PRK07024
414684004152	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
414684004153	NAD(P) binding site [chemical binding]; other site
414684004154	active site
414684004155	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
414684004156	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
414684004157	hypothetical protein; Provisional; Region: PRK11820
414684004158	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
414684004159	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
414684004160	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
414684004161	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
414684004162	catalytic site [active]
414684004163	G-X2-G-X-G-K; other site
414684004164	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
414684004165	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
414684004166	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
414684004167	SurA N-terminal domain; Region: SurA_N; pfam09312
414684004168	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
414684004169	Predicted permeases [General function prediction only]; Region: COG0795
414684004170	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
414684004171	Predicted permeases [General function prediction only]; Region: COG0795
414684004172	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
414684004173	multifunctional aminopeptidase A; Provisional; Region: PRK00913
414684004174	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
414684004175	interface (dimer of trimers) [polypeptide binding]; other site
414684004176	Substrate-binding/catalytic site; other site
414684004177	Zn-binding sites [ion binding]; other site
414684004178	DNA polymerase III subunit chi; Validated; Region: PRK05728
414684004179	YceG-like family; Region: YceG; pfam02618
414684004180	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
414684004181	dimerization interface [polypeptide binding]; other site
414684004182	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
414684004183	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
414684004184	dimer interface [polypeptide binding]; other site
414684004185	active site
414684004186	acyl carrier protein; Provisional; Region: acpP; PRK00982
414684004187	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
414684004188	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
414684004189	NAD(P) binding site [chemical binding]; other site
414684004190	active site
414684004191	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
414684004192	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
414684004193	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
414684004194	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
414684004195	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
414684004196	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
414684004197	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
414684004198	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
414684004199	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684004200	S-adenosylmethionine binding site [chemical binding]; other site
414684004201	replicative DNA helicase; Provisional; Region: PRK09165
414684004202	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
414684004203	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
414684004204	Walker A motif; other site
414684004205	ATP binding site [chemical binding]; other site
414684004206	Walker B motif; other site
414684004207	DNA binding loops [nucleotide binding]
414684004208	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
414684004209	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
414684004210	active site
414684004211	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
414684004212	dimer interface [polypeptide binding]; other site
414684004213	substrate binding site [chemical binding]; other site
414684004214	catalytic residues [active]
414684004215	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
414684004216	Permease; Region: Permease; pfam02405
414684004217	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
414684004218	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
414684004219	Walker A/P-loop; other site
414684004220	ATP binding site [chemical binding]; other site
414684004221	Q-loop/lid; other site
414684004222	ABC transporter signature motif; other site
414684004223	Walker B; other site
414684004224	D-loop; other site
414684004225	H-loop/switch region; other site
414684004226	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
414684004227	KaiC; Region: KaiC; pfam06745
414684004228	Walker A motif; other site
414684004229	ATP binding site [chemical binding]; other site
414684004230	Walker B motif; other site
414684004231	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
414684004232	Colicin V production protein; Region: Colicin_V; pfam02674
414684004233	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
414684004234	amidophosphoribosyltransferase; Provisional; Region: PRK09123
414684004235	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
414684004236	active site
414684004237	tetramer interface [polypeptide binding]; other site
414684004238	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
414684004239	active site
414684004240	classical (c) SDRs; Region: SDR_c; cd05233
414684004241	NAD(P) binding site [chemical binding]; other site
414684004242	active site
414684004243	choline dehydrogenase; Validated; Region: PRK02106
414684004244	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
414684004245	glutathione reductase; Validated; Region: PRK06116
414684004246	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
414684004247	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
414684004248	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
414684004249	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
414684004250	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
414684004251	response regulator; Provisional; Region: PRK13435
414684004252	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684004253	active site
414684004254	phosphorylation site [posttranslational modification]
414684004255	intermolecular recognition site; other site
414684004256	dimerization interface [polypeptide binding]; other site
414684004257	succinic semialdehyde dehydrogenase; Region: PLN02278
414684004258	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
414684004259	tetramerization interface [polypeptide binding]; other site
414684004260	NAD(P) binding site [chemical binding]; other site
414684004261	catalytic residues [active]
414684004262	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
414684004263	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
414684004264	Substrate binding site; other site
414684004265	Mg++ binding site; other site
414684004266	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
414684004267	active site
414684004268	substrate binding site [chemical binding]; other site
414684004269	CoA binding site [chemical binding]; other site
414684004270	phosphoglycolate phosphatase; Provisional; Region: PRK13222
414684004271	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
414684004272	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
414684004273	motif II; other site
414684004274	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
414684004275	Dynamin family; Region: Dynamin_N; pfam00350
414684004276	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
414684004277	G1 box; other site
414684004278	GTP/Mg2+ binding site [chemical binding]; other site
414684004279	G2 box; other site
414684004280	Switch I region; other site
414684004281	G3 box; other site
414684004282	Switch II region; other site
414684004283	G4 box; other site
414684004284	Predicted membrane protein [Function unknown]; Region: COG2261
414684004285	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
414684004286	Staphylococcal nuclease homologues; Region: SNc; smart00318
414684004287	Catalytic site; other site
414684004288	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
414684004289	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
414684004290	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
414684004291	active site
414684004292	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
414684004293	dinuclear metal binding motif [ion binding]; other site
414684004294	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
414684004295	peptide chain release factor 2; Provisional; Region: PRK07342
414684004296	This domain is found in peptide chain release factors; Region: PCRF; smart00937
414684004297	RF-1 domain; Region: RF-1; pfam00472
414684004298	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
414684004299	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
414684004300	Transglycosylase; Region: Transgly; pfam00912
414684004301	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
414684004302	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
414684004303	AMIN domain; Region: AMIN; pfam11741
414684004304	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
414684004305	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
414684004306	active site
414684004307	metal binding site [ion binding]; metal-binding site
414684004308	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
414684004309	homodimer interface [polypeptide binding]; other site
414684004310	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
414684004311	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
414684004312	Transposase domain (DUF772); Region: DUF772; pfam05598
414684004313	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
414684004314	Putative transcription activator [Transcription]; Region: TenA; COG0819
414684004315	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
414684004316	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
414684004317	catalytic loop [active]
414684004318	iron binding site [ion binding]; other site
414684004319	Double zinc ribbon; Region: DZR; pfam12773
414684004320	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
414684004321	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
414684004322	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
414684004323	catalytic residue [active]
414684004324	Predicted transcriptional regulator [Transcription]; Region: COG1959
414684004325	Transcriptional regulator; Region: Rrf2; cl17282
414684004326	serine O-acetyltransferase; Region: cysE; TIGR01172
414684004327	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
414684004328	trimer interface [polypeptide binding]; other site
414684004329	active site
414684004330	substrate binding site [chemical binding]; other site
414684004331	CoA binding site [chemical binding]; other site
414684004332	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
414684004333	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
414684004334	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
414684004335	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
414684004336	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
414684004337	active site
414684004338	HIGH motif; other site
414684004339	dimer interface [polypeptide binding]; other site
414684004340	KMSKS motif; other site
414684004341	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
414684004342	RNA binding surface [nucleotide binding]; other site
414684004343	Protein of unknown function; Region: DUF3971; pfam13116
414684004344	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
414684004345	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
414684004346	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
414684004347	metal binding triad; other site
414684004348	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
414684004349	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
414684004350	metal binding triad; other site
414684004351	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
414684004352	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
414684004353	catalytic triad [active]
414684004354	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
414684004355	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
414684004356	P-loop; other site
414684004357	Magnesium ion binding site [ion binding]; other site
414684004358	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
414684004359	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
414684004360	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
414684004361	FAD binding domain; Region: FAD_binding_4; pfam01565
414684004362	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
414684004363	catalytic residue [active]
414684004364	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
414684004365	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
414684004366	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
414684004367	active site
414684004368	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
414684004369	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
414684004370	Peptidase propeptide and YPEB domain; Region: PepSY_2; cl17877
414684004371	RNA polymerase sigma factor; Provisional; Region: PRK11924
414684004372	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
414684004373	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
414684004374	DNA binding residues [nucleotide binding]
414684004375	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
414684004376	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
414684004377	N-acetyl-D-glucosamine binding site [chemical binding]; other site
414684004378	catalytic residue [active]
414684004379	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
414684004380	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
414684004381	FtsX-like permease family; Region: FtsX; pfam02687
414684004382	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
414684004383	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
414684004384	Walker A/P-loop; other site
414684004385	ATP binding site [chemical binding]; other site
414684004386	Q-loop/lid; other site
414684004387	ABC transporter signature motif; other site
414684004388	Walker B; other site
414684004389	D-loop; other site
414684004390	H-loop/switch region; other site
414684004391	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
414684004392	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
414684004393	HlyD family secretion protein; Region: HlyD_3; pfam13437
414684004394	Domain of unknown function (DUF329); Region: DUF329; pfam03884
414684004395	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
414684004396	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
414684004397	RNA binding site [nucleotide binding]; other site
414684004398	Maf-like protein; Region: Maf; pfam02545
414684004399	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
414684004400	active site
414684004401	dimer interface [polypeptide binding]; other site
414684004402	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
414684004403	rRNA binding site [nucleotide binding]; other site
414684004404	predicted 30S ribosome binding site; other site
414684004405	Low molecular weight phosphatase family; Region: LMWPc; cd00115
414684004406	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
414684004407	active site
414684004408	hypothetical protein; Provisional; Region: PRK02853
414684004409	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
414684004410	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
414684004411	NAD binding site [chemical binding]; other site
414684004412	dimerization interface [polypeptide binding]; other site
414684004413	product binding site; other site
414684004414	substrate binding site [chemical binding]; other site
414684004415	zinc binding site [ion binding]; other site
414684004416	catalytic residues [active]
414684004417	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
414684004418	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
414684004419	Protein of unknown function (DUF2948); Region: DUF2948; pfam11164
414684004420	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
414684004421	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
414684004422	hinge; other site
414684004423	active site
414684004424	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
414684004425	trimer interface [polypeptide binding]; other site
414684004426	active site
414684004427	Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297
414684004428	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
414684004429	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
414684004430	NAD(P) binding site [chemical binding]; other site
414684004431	active site
414684004432	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
414684004433	Sel1-like repeats; Region: SEL1; smart00671
414684004434	Sel1-like repeats; Region: SEL1; smart00671
414684004435	O-Antigen ligase; Region: Wzy_C; pfam04932
414684004436	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
414684004437	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
414684004438	putative active site [active]
414684004439	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
414684004440	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
414684004441	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
414684004442	PRC-barrel domain; Region: PRC; pfam05239
414684004443	pyruvate phosphate dikinase; Provisional; Region: PRK09279
414684004444	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
414684004445	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
414684004446	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
414684004447	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
414684004448	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
414684004449	dimer interface [polypeptide binding]; other site
414684004450	motif 1; other site
414684004451	active site
414684004452	motif 2; other site
414684004453	motif 3; other site
414684004454	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
414684004455	PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815
414684004456	PA/protease or protease-like domain interface [polypeptide binding]; other site
414684004457	M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883
414684004458	Peptidase family M28; Region: Peptidase_M28; pfam04389
414684004459	metal binding site [ion binding]; metal-binding site
414684004460	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
414684004461	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
414684004462	oligomer interface [polypeptide binding]; other site
414684004463	tandem repeat interface [polypeptide binding]; other site
414684004464	active site residues [active]
414684004465	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684004466	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
414684004467	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
414684004468	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
414684004469	substrate binding pocket [chemical binding]; other site
414684004470	chain length determination region; other site
414684004471	substrate-Mg2+ binding site; other site
414684004472	catalytic residues [active]
414684004473	aspartate-rich region 1; other site
414684004474	active site lid residues [active]
414684004475	aspartate-rich region 2; other site
414684004476	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
414684004477	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
414684004478	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
414684004479	active site
414684004480	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
414684004481	catalytic triad [active]
414684004482	metal binding site [ion binding]; metal-binding site
414684004483	conserved cis-peptide bond; other site
414684004484	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
414684004485	nucleoside/Zn binding site; other site
414684004486	dimer interface [polypeptide binding]; other site
414684004487	catalytic motif [active]
414684004488	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
414684004489	ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264
414684004490	Walker A/P-loop; other site
414684004491	ATP binding site [chemical binding]; other site
414684004492	Q-loop/lid; other site
414684004493	ABC transporter signature motif; other site
414684004494	Walker B; other site
414684004495	D-loop; other site
414684004496	H-loop/switch region; other site
414684004497	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
414684004498	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
414684004499	Zn binding site [ion binding]; other site
414684004500	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
414684004501	Major Facilitator Superfamily; Region: MFS_1; pfam07690
414684004502	Winged helix-turn helix; Region: HTH_29; pfam13551
414684004503	Helix-turn-helix domain; Region: HTH_28; pfam13518
414684004504	Winged helix-turn helix; Region: HTH_33; pfam13592
414684004505	DDE superfamily endonuclease; Region: DDE_3; pfam13358
414684004506	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
414684004507	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
414684004508	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
414684004509	Walker A motif; other site
414684004510	ATP binding site [chemical binding]; other site
414684004511	Walker B motif; other site
414684004512	arginine finger; other site
414684004513	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
414684004514	Walker A motif; other site
414684004515	ATP binding site [chemical binding]; other site
414684004516	Walker B motif; other site
414684004517	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
414684004518	Uncharacterized conserved protein [Function unknown]; Region: COG2127
414684004519	Phasin protein; Region: Phasin_2; pfam09361
414684004520	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
414684004521	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
414684004522	active site
414684004523	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
414684004524	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
414684004525	Sporulation related domain; Region: SPOR; pfam05036
414684004526	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
414684004527	active site
414684004528	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
414684004529	substrate binding site [chemical binding]; other site
414684004530	metal binding site [ion binding]; metal-binding site
414684004531	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
414684004532	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
414684004533	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
414684004534	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
414684004535	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
414684004536	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
414684004537	active site
414684004538	tetramer interface; other site
414684004539	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
414684004540	HSP70 interaction site [polypeptide binding]; other site
414684004541	von Willebrand factor type A domain; Region: VWA_2; pfam13519
414684004542	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330
414684004543	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
414684004544	active site
414684004545	catalytic site [active]
414684004546	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
414684004547	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684004548	active site
414684004549	phosphorylation site [posttranslational modification]
414684004550	intermolecular recognition site; other site
414684004551	dimerization interface [polypeptide binding]; other site
414684004552	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
414684004553	DNA binding residues [nucleotide binding]
414684004554	dimerization interface [polypeptide binding]; other site
414684004555	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684004556	S-adenosylmethionine binding site [chemical binding]; other site
414684004557	hypothetical protein; Provisional; Region: PRK10279
414684004558	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
414684004559	active site
414684004560	nucleophile elbow; other site
414684004561	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
414684004562	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
414684004563	HI0933-like protein; Region: HI0933_like; pfam03486
414684004564	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
414684004565	Predicted transcriptional regulator [Transcription]; Region: COG2944
414684004566	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
414684004567	Protein of unknown function (DUF497); Region: DUF497; cl01108
414684004568	hypothetical protein; Provisional; Region: PRK09256
414684004569	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
414684004570	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
414684004571	Coenzyme A binding pocket [chemical binding]; other site
414684004572	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
414684004573	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
414684004574	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
414684004575	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
414684004576	Mg++ binding site [ion binding]; other site
414684004577	putative catalytic motif [active]
414684004578	putative substrate binding site [chemical binding]; other site
414684004579	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
414684004580	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
414684004581	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
414684004582	catalytic residue [active]
414684004583	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
414684004584	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
414684004585	Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393
414684004586	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
414684004587	motif 1; other site
414684004588	dimer interface [polypeptide binding]; other site
414684004589	active site
414684004590	motif 2; other site
414684004591	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
414684004592	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
414684004593	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
414684004594	GDP-binding site [chemical binding]; other site
414684004595	ACT binding site; other site
414684004596	IMP binding site; other site
414684004597	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
414684004598	active site
414684004599	ATP binding site [chemical binding]; other site
414684004600	substrate binding site [chemical binding]; other site
414684004601	activation loop (A-loop); other site
414684004602	short chain dehydrogenase; Provisional; Region: PRK06180
414684004603	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
414684004604	NADP binding site [chemical binding]; other site
414684004605	active site
414684004606	steroid binding site; other site
414684004607	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
414684004608	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
414684004609	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
414684004610	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
414684004611	DNA binding residues [nucleotide binding]
414684004612	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
414684004613	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
414684004614	RNA binding surface [nucleotide binding]; other site
414684004615	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
414684004616	active site
414684004617	type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931
414684004618	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
414684004619	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
414684004620	tetramer interface [polypeptide binding]; other site
414684004621	pyridoxal 5'-phosphate binding site [chemical binding]; other site
414684004622	catalytic residue [active]
414684004623	DDE superfamily endonuclease; Region: DDE_3; pfam13358
414684004624	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
414684004625	Winged helix-turn helix; Region: HTH_29; pfam13551
414684004626	Helix-turn-helix domain; Region: HTH_28; pfam13518
414684004627	Winged helix-turn helix; Region: HTH_33; pfam13592
414684004628	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
414684004629	Walker A/P-loop; other site
414684004630	ATP binding site [chemical binding]; other site
414684004631	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
414684004632	AAA domain; Region: AAA_12; pfam13087
414684004633	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
414684004634	Fatty acid desaturase; Region: FA_desaturase; pfam00487
414684004635	Di-iron ligands [ion binding]; other site
414684004636	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
414684004637	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
414684004638	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
414684004639	DctM-like transporters; Region: DctM; pfam06808
414684004640	Predicted membrane protein (DUF2243); Region: DUF2243; cl01783
414684004641	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
414684004642	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
414684004643	substrate binding site [chemical binding]; other site
414684004644	oxyanion hole (OAH) forming residues; other site
414684004645	trimer interface [polypeptide binding]; other site
414684004646	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
414684004647	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
414684004648	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
414684004649	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
414684004650	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
414684004651	dimer interface [polypeptide binding]; other site
414684004652	active site
414684004653	Protein of unknown function (DUF454); Region: DUF454; cl01063
414684004654	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
414684004655	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
414684004656	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
414684004657	putative active site [active]
414684004658	glycogen branching enzyme; Provisional; Region: PRK05402
414684004659	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
414684004660	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
414684004661	active site
414684004662	catalytic site [active]
414684004663	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
414684004664	4-alpha-glucanotransferase; Provisional; Region: PRK14508
414684004665	Domain of unknown function (DUF4032); Region: DUF4032; pfam13224
414684004666	flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927
414684004667	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
414684004668	Walker A motif/ATP binding site; other site
414684004669	Walker B motif; other site
414684004670	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
414684004671	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684004672	active site
414684004673	phosphorylation site [posttranslational modification]
414684004674	intermolecular recognition site; other site
414684004675	dimerization interface [polypeptide binding]; other site
414684004676	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
414684004677	DNA binding site [nucleotide binding]
414684004678	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
414684004679	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
414684004680	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
414684004681	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
414684004682	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684004683	S-adenosylmethionine binding site [chemical binding]; other site
414684004684	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
414684004685	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684004686	active site
414684004687	phosphorylation site [posttranslational modification]
414684004688	intermolecular recognition site; other site
414684004689	dimerization interface [polypeptide binding]; other site
414684004690	CheB methylesterase; Region: CheB_methylest; pfam01339
414684004691	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684004692	Response regulator receiver domain; Region: Response_reg; pfam00072
414684004693	active site
414684004694	phosphorylation site [posttranslational modification]
414684004695	intermolecular recognition site; other site
414684004696	dimerization interface [polypeptide binding]; other site
414684004697	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
414684004698	putative CheA interaction surface; other site
414684004699	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
414684004700	putative binding surface; other site
414684004701	active site
414684004702	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
414684004703	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
414684004704	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684004705	ATP binding site [chemical binding]; other site
414684004706	Mg2+ binding site [ion binding]; other site
414684004707	G-X-G motif; other site
414684004708	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
414684004709	CheW-like domain; Region: CheW; pfam01584
414684004710	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
414684004711	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684004712	active site
414684004713	phosphorylation site [posttranslational modification]
414684004714	intermolecular recognition site; other site
414684004715	dimerization interface [polypeptide binding]; other site
414684004716	Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090
414684004717	Protein of unknown function (DUF3553); Region: DUF3553; pfam12073
414684004718	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
414684004719	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
414684004720	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
414684004721	FeS/SAM binding site; other site
414684004722	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
414684004723	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
414684004724	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
414684004725	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
414684004726	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_7; cd06910
414684004727	putative active site [active]
414684004728	Zn binding site [ion binding]; other site
414684004729	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
414684004730	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
414684004731	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
414684004732	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045
414684004733	CreA protein; Region: CreA; pfam05981
414684004734	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
414684004735	Domain of unknown function DUF20; Region: UPF0118; pfam01594
414684004736	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
414684004737	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
414684004738	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
414684004739	HRDC domain; Region: HRDC; pfam00570
414684004740	SapC; Region: SapC; pfam07277
414684004741	hypothetical protein; Validated; Region: PRK07586
414684004742	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
414684004743	PYR/PP interface [polypeptide binding]; other site
414684004744	dimer interface [polypeptide binding]; other site
414684004745	TPP binding site [chemical binding]; other site
414684004746	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
414684004747	TPP-binding site [chemical binding]; other site
414684004748	dimer interface [polypeptide binding]; other site
414684004749	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
414684004750	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
414684004751	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
414684004752	NAD binding site [chemical binding]; other site
414684004753	Phe binding site; other site
414684004754	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
414684004755	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
414684004756	Response regulator receiver domain; Region: Response_reg; pfam00072
414684004757	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684004758	active site
414684004759	phosphorylation site [posttranslational modification]
414684004760	intermolecular recognition site; other site
414684004761	dimerization interface [polypeptide binding]; other site
414684004762	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
414684004763	putative binding surface; other site
414684004764	active site
414684004765	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
414684004766	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684004767	active site
414684004768	phosphorylation site [posttranslational modification]
414684004769	intermolecular recognition site; other site
414684004770	dimerization interface [polypeptide binding]; other site
414684004771	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
414684004772	DNA binding site [nucleotide binding]
414684004773	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
414684004774	Proline dehydrogenase; Region: Pro_dh; pfam01619
414684004775	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
414684004776	Glutamate binding site [chemical binding]; other site
414684004777	NAD binding site [chemical binding]; other site
414684004778	catalytic residues [active]
414684004779	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
414684004780	putative DNA binding site [nucleotide binding]; other site
414684004781	putative Zn2+ binding site [ion binding]; other site
414684004782	AsnC family; Region: AsnC_trans_reg; pfam01037
414684004783	hypothetical protein; Provisional; Region: PRK13687
414684004784	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
414684004785	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
414684004786	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684004787	putative CheW interface [polypeptide binding]; other site
414684004788	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
414684004789	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
414684004790	ligand binding site [chemical binding]; other site
414684004791	NAD binding site [chemical binding]; other site
414684004792	dimerization interface [polypeptide binding]; other site
414684004793	catalytic site [active]
414684004794	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
414684004795	putative L-serine binding site [chemical binding]; other site
414684004796	Protein of unknown function, DUF486; Region: DUF486; cl01236
414684004797	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
414684004798	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
414684004799	catalytic residue [active]
414684004800	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
414684004801	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
414684004802	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
414684004803	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
414684004804	Coenzyme A binding pocket [chemical binding]; other site
414684004805	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
414684004806	dimer interface [polypeptide binding]; other site
414684004807	substrate binding site [chemical binding]; other site
414684004808	ATP binding site [chemical binding]; other site
414684004809	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
414684004810	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
414684004811	active site
414684004812	substrate binding site [chemical binding]; other site
414684004813	metal binding site [ion binding]; metal-binding site
414684004814	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
414684004815	dihydropteroate synthase; Region: DHPS; TIGR01496
414684004816	substrate binding pocket [chemical binding]; other site
414684004817	dimer interface [polypeptide binding]; other site
414684004818	inhibitor binding site; inhibition site
414684004819	FtsH Extracellular; Region: FtsH_ext; pfam06480
414684004820	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
414684004821	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
414684004822	Walker A motif; other site
414684004823	ATP binding site [chemical binding]; other site
414684004824	Walker B motif; other site
414684004825	arginine finger; other site
414684004826	Peptidase family M41; Region: Peptidase_M41; pfam01434
414684004827	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
414684004828	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
414684004829	Ligand Binding Site [chemical binding]; other site
414684004830	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
414684004831	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
414684004832	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
414684004833	ligand binding site [chemical binding]; other site
414684004834	translocation protein TolB; Provisional; Region: tolB; PRK05137
414684004835	TolB amino-terminal domain; Region: TolB_N; pfam04052
414684004836	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
414684004837	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
414684004838	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
414684004839	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
414684004840	TolR protein; Region: tolR; TIGR02801
414684004841	TolQ protein; Region: tolQ; TIGR02796
414684004842	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
414684004843	active site
414684004844	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
414684004845	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
414684004846	Walker A motif; other site
414684004847	ATP binding site [chemical binding]; other site
414684004848	Walker B motif; other site
414684004849	arginine finger; other site
414684004850	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
414684004851	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
414684004852	RuvA N terminal domain; Region: RuvA_N; pfam01330
414684004853	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
414684004854	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
414684004855	active site
414684004856	putative DNA-binding cleft [nucleotide binding]; other site
414684004857	dimer interface [polypeptide binding]; other site
414684004858	hypothetical protein; Validated; Region: PRK00110
414684004859	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
414684004860	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
414684004861	putative active site [active]
414684004862	metal binding site [ion binding]; metal-binding site
414684004863	homodimer binding site [polypeptide binding]; other site
414684004864	5-formyltetrahydrofolate cyclo-ligase, pseudogene;identified by match to protein family HMM TIGR00097
414684004865	Cell division protein ZapA; Region: ZapA; pfam05164
414684004866	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
414684004867	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
414684004868	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
414684004869	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
414684004870	Walker A/P-loop; other site
414684004871	ATP binding site [chemical binding]; other site
414684004872	Q-loop/lid; other site
414684004873	ABC transporter signature motif; other site
414684004874	Walker B; other site
414684004875	D-loop; other site
414684004876	H-loop/switch region; other site
414684004877	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
414684004878	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
414684004879	TPP-binding site [chemical binding]; other site
414684004880	dimer interface [polypeptide binding]; other site
414684004881	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
414684004882	PYR/PP interface [polypeptide binding]; other site
414684004883	dimer interface [polypeptide binding]; other site
414684004884	TPP binding site [chemical binding]; other site
414684004885	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
414684004886	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
414684004887	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
414684004888	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
414684004889	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
414684004890	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
414684004891	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
414684004892	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
414684004893	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
414684004894	Class I aldolases; Region: Aldolase_Class_I; cl17187
414684004895	catalytic residue [active]
414684004896	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
414684004897	thiamine phosphate binding site [chemical binding]; other site
414684004898	active site
414684004899	pyrophosphate binding site [ion binding]; other site
414684004900	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
414684004901	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
414684004902	motif 1; other site
414684004903	dimer interface [polypeptide binding]; other site
414684004904	active site
414684004905	motif 2; other site
414684004906	motif 3; other site
414684004907	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
414684004908	hypothetical protein; Validated; Region: PRK09039
414684004909	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
414684004910	ligand binding site [chemical binding]; other site
414684004911	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
414684004912	ligand binding site [chemical binding]; other site
414684004913	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
414684004914	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
414684004915	active site
414684004916	dimerization interface [polypeptide binding]; other site
414684004917	elongation factor P; Validated; Region: PRK00529
414684004918	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
414684004919	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
414684004920	RNA binding site [nucleotide binding]; other site
414684004921	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
414684004922	RNA binding site [nucleotide binding]; other site
414684004923	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
414684004924	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
414684004925	TM-ABC transporter signature motif; other site
414684004926	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
414684004927	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
414684004928	TM-ABC transporter signature motif; other site
414684004929	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
414684004930	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
414684004931	Walker A/P-loop; other site
414684004932	ATP binding site [chemical binding]; other site
414684004933	Q-loop/lid; other site
414684004934	ABC transporter signature motif; other site
414684004935	Walker B; other site
414684004936	D-loop; other site
414684004937	H-loop/switch region; other site
414684004938	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
414684004939	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
414684004940	Walker A/P-loop; other site
414684004941	ATP binding site [chemical binding]; other site
414684004942	Q-loop/lid; other site
414684004943	ABC transporter signature motif; other site
414684004944	Walker B; other site
414684004945	D-loop; other site
414684004946	H-loop/switch region; other site
414684004947	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
414684004948	Cache domain; Region: Cache_1; pfam02743
414684004949	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
414684004950	dimerization interface [polypeptide binding]; other site
414684004951	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
414684004952	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684004953	dimer interface [polypeptide binding]; other site
414684004954	putative CheW interface [polypeptide binding]; other site
414684004955	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
414684004956	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
414684004957	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
414684004958	Walker A/P-loop; other site
414684004959	ATP binding site [chemical binding]; other site
414684004960	Q-loop/lid; other site
414684004961	ABC transporter signature motif; other site
414684004962	Walker B; other site
414684004963	D-loop; other site
414684004964	H-loop/switch region; other site
414684004965	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
414684004966	Protein of unknown function (DUF1465); Region: DUF1465; cl11562
414684004967	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
414684004968	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
414684004969	putative dimer interface [polypeptide binding]; other site
414684004970	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
414684004971	RNA polymerase factor sigma-70; Validated; Region: PRK09047
414684004972	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
414684004973	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
414684004974	DNA binding residues [nucleotide binding]
414684004975	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
414684004976	Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967
414684004977	acyl-activating enzyme (AAE) consensus motif; other site
414684004978	putative AMP binding site [chemical binding]; other site
414684004979	putative active site [active]
414684004980	putative CoA binding site [chemical binding]; other site
414684004981	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
414684004982	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
414684004983	active site
414684004984	nucleophile elbow; other site
414684004985	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
414684004986	d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940
414684004987	NAD binding site [chemical binding]; other site
414684004988	homotetramer interface [polypeptide binding]; other site
414684004989	homodimer interface [polypeptide binding]; other site
414684004990	substrate binding site [chemical binding]; other site
414684004991	active site
414684004992	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
414684004993	Domain of unknown function (DUF4169); Region: DUF4169; pfam13770
414684004994	phosphoribosylaminoimidazole carboxylase, PurK protein; Region: purK; TIGR01161
414684004995	ATP-grasp domain; Region: ATP-grasp; pfam02222
414684004996	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
414684004997	6-phosphofructokinase; Provisional; Region: PRK14071
414684004998	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
414684004999	active site
414684005000	ADP/pyrophosphate binding site [chemical binding]; other site
414684005001	dimerization interface [polypeptide binding]; other site
414684005002	allosteric effector site; other site
414684005003	fructose-1,6-bisphosphate binding site; other site
414684005004	Protein of unknown function (DUF2390); Region: DUF2390; pfam09523
414684005005	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
414684005006	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
414684005007	active site
414684005008	Zn binding site [ion binding]; other site
414684005009	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
414684005010	Flavoprotein; Region: Flavoprotein; pfam02441
414684005011	Protein of unknown function (DUF465); Region: DUF465; pfam04325
414684005012	Protein of unknown function (DUF1013); Region: DUF1013; pfam06242
414684005013	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
414684005014	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
414684005015	NAD(P) binding site [chemical binding]; other site
414684005016	Protein of unknown function (DUF1192); Region: DUF1192; pfam06698
414684005017	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
414684005018	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
414684005019	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
414684005020	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
414684005021	N-terminal plug; other site
414684005022	ligand-binding site [chemical binding]; other site
414684005023	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
414684005024	fumarate hydratase; Reviewed; Region: fumC; PRK00485
414684005025	Class II fumarases; Region: Fumarase_classII; cd01362
414684005026	active site
414684005027	tetramer interface [polypeptide binding]; other site
414684005028	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
414684005029	Uncharacterized conserved protein [Function unknown]; Region: COG2013
414684005030	Protein of unknown function (DUF533); Region: DUF533; pfam04391
414684005031	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
414684005032	putative metal binding site [ion binding]; other site
414684005033	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
414684005034	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
414684005035	elongation factor G; Reviewed; Region: PRK12740
414684005036	G1 box; other site
414684005037	putative GEF interaction site [polypeptide binding]; other site
414684005038	GTP/Mg2+ binding site [chemical binding]; other site
414684005039	Switch I region; other site
414684005040	G2 box; other site
414684005041	G3 box; other site
414684005042	Switch II region; other site
414684005043	G4 box; other site
414684005044	G5 box; other site
414684005045	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
414684005046	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
414684005047	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
414684005048	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
414684005049	active site
414684005050	metal-binding site
414684005051	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
414684005052	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
414684005053	dimerization interface [polypeptide binding]; other site
414684005054	DPS ferroxidase diiron center [ion binding]; other site
414684005055	ion pore; other site
414684005056	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
414684005057	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
414684005058	dimerization interface [polypeptide binding]; other site
414684005059	DPS ferroxidase diiron center [ion binding]; other site
414684005060	ion pore; other site
414684005061	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
414684005062	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
414684005063	putative C-terminal domain interface [polypeptide binding]; other site
414684005064	putative GSH binding site (G-site) [chemical binding]; other site
414684005065	putative dimer interface [polypeptide binding]; other site
414684005066	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
414684005067	dimer interface [polypeptide binding]; other site
414684005068	N-terminal domain interface [polypeptide binding]; other site
414684005069	putative substrate binding pocket (H-site) [chemical binding]; other site
414684005070	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
414684005071	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
414684005072	Ligand Binding Site [chemical binding]; other site
414684005073	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
414684005074	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
414684005075	aspartate aminotransferase; Provisional; Region: PRK05764
414684005076	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
414684005077	pyridoxal 5'-phosphate binding site [chemical binding]; other site
414684005078	homodimer interface [polypeptide binding]; other site
414684005079	catalytic residue [active]
414684005080	excinuclease ABC subunit B; Provisional; Region: PRK05298
414684005081	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
414684005082	ATP binding site [chemical binding]; other site
414684005083	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
414684005084	nucleotide binding region [chemical binding]; other site
414684005085	ATP-binding site [chemical binding]; other site
414684005086	Ultra-violet resistance protein B; Region: UvrB; pfam12344
414684005087	UvrB/uvrC motif; Region: UVR; pfam02151
414684005088	short chain dehydrogenase; Provisional; Region: PRK09134
414684005089	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
414684005090	NAD(P) binding site [chemical binding]; other site
414684005091	active site
414684005092	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
414684005093	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
414684005094	GIY-YIG motif/motif A; other site
414684005095	active site
414684005096	catalytic site [active]
414684005097	putative DNA binding site [nucleotide binding]; other site
414684005098	metal binding site [ion binding]; metal-binding site
414684005099	UvrB/uvrC motif; Region: UVR; pfam02151
414684005100	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
414684005101	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
414684005102	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
414684005103	MoaE interaction surface [polypeptide binding]; other site
414684005104	MoeB interaction surface [polypeptide binding]; other site
414684005105	thiocarboxylated glycine; other site
414684005106	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
414684005107	MoaE homodimer interface [polypeptide binding]; other site
414684005108	MoaD interaction [polypeptide binding]; other site
414684005109	active site residues [active]
414684005110	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
414684005111	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684005112	active site
414684005113	phosphorylation site [posttranslational modification]
414684005114	intermolecular recognition site; other site
414684005115	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
414684005116	dimerization interface [polypeptide binding]; other site
414684005117	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684005118	dimer interface [polypeptide binding]; other site
414684005119	phosphorylation site [posttranslational modification]
414684005120	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684005121	ATP binding site [chemical binding]; other site
414684005122	Mg2+ binding site [ion binding]; other site
414684005123	G-X-G motif; other site
414684005124	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
414684005125	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
414684005126	homodimer interface [polypeptide binding]; other site
414684005127	substrate-cofactor binding pocket; other site
414684005128	catalytic residue [active]
414684005129	MarR family; Region: MarR_2; pfam12802
414684005130	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
414684005131	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684005132	active site
414684005133	phosphorylation site [posttranslational modification]
414684005134	intermolecular recognition site; other site
414684005135	dimerization interface [polypeptide binding]; other site
414684005136	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
414684005137	DNA binding site [nucleotide binding]
414684005138	HAMP domain; Region: HAMP; pfam00672
414684005139	dimerization interface [polypeptide binding]; other site
414684005140	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684005141	dimer interface [polypeptide binding]; other site
414684005142	phosphorylation site [posttranslational modification]
414684005143	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684005144	ATP binding site [chemical binding]; other site
414684005145	Mg2+ binding site [ion binding]; other site
414684005146	G-X-G motif; other site
414684005147	Phasin protein; Region: Phasin_2; pfam09361
414684005148	COQ9; Region: COQ9; pfam08511
414684005149	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
414684005150	putative deacylase active site [active]
414684005151	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
414684005152	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
414684005153	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
414684005154	Membrane fusogenic activity; Region: BMFP; pfam04380
414684005155	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
414684005156	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
414684005157	NADP binding site [chemical binding]; other site
414684005158	homopentamer interface [polypeptide binding]; other site
414684005159	substrate binding site [chemical binding]; other site
414684005160	active site
414684005161	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
414684005162	Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636
414684005163	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
414684005164	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
414684005165	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
414684005166	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
414684005167	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
414684005168	active site
414684005169	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
414684005170	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
414684005171	5S rRNA interface [nucleotide binding]; other site
414684005172	CTC domain interface [polypeptide binding]; other site
414684005173	L16 interface [polypeptide binding]; other site
414684005174	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
414684005175	putative active site [active]
414684005176	catalytic residue [active]
414684005177	Protein of unknown function (DUF1044); Region: DUF1044; cl01955
414684005178	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
414684005179	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
414684005180	putative catalytic cysteine [active]
414684005181	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
414684005182	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
414684005183	active site
414684005184	(T/H)XGH motif; other site
414684005185	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
414684005186	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
414684005187	TPR repeat; Region: TPR_11; pfam13414
414684005188	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
414684005189	TPR motif; other site
414684005190	TPR repeat; Region: TPR_11; pfam13414
414684005191	binding surface
414684005192	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
414684005193	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
414684005194	Ligand binding site; other site
414684005195	Putative Catalytic site; other site
414684005196	DXD motif; other site
414684005197	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627
414684005198	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
414684005199	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
414684005200	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
414684005201	homotrimer interaction site [polypeptide binding]; other site
414684005202	putative active site [active]
414684005203	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
414684005204	Protein of unknown function, DUF482; Region: DUF482; pfam04339
414684005205	WYL domain; Region: WYL; pfam13280
414684005206	The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910
414684005207	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
414684005208	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
414684005209	CRISPR/Cas system-associated protein Csx14; Region: Csx14_I-U; cd09765
414684005210	CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834
414684005211	CRISPR-associated protein GSU0054/csb2, Dpsyc system; Region: cas_GSU0054; TIGR02165
414684005212	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
414684005213	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
414684005214	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
414684005215	Secretin and TonB N terminus short domain; Region: STN; smart00965
414684005216	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
414684005217	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
414684005218	N-terminal plug; other site
414684005219	ligand-binding site [chemical binding]; other site
414684005220	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
414684005221	FecR protein; Region: FecR; pfam04773
414684005222	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
414684005223	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
414684005224	DNA binding residues [nucleotide binding]
414684005225	Pirin-related protein [General function prediction only]; Region: COG1741
414684005226	Pirin; Region: Pirin; pfam02678
414684005227	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
414684005228	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
414684005229	Transcriptional regulator [Transcription]; Region: LysR; COG0583
414684005230	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
414684005231	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
414684005232	putative effector binding pocket; other site
414684005233	dimerization interface [polypeptide binding]; other site
414684005234	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
414684005235	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
414684005236	C-terminal domain interface [polypeptide binding]; other site
414684005237	GSH binding site (G-site) [chemical binding]; other site
414684005238	dimer interface [polypeptide binding]; other site
414684005239	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
414684005240	putative dimer interface [polypeptide binding]; other site
414684005241	N-terminal domain interface [polypeptide binding]; other site
414684005242	active site
414684005243	short chain dehydrogenase; Provisional; Region: PRK07576
414684005244	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
414684005245	NAD(P) binding site [chemical binding]; other site
414684005246	substrate binding site [chemical binding]; other site
414684005247	homotetramer interface [polypeptide binding]; other site
414684005248	active site
414684005249	homodimer interface [polypeptide binding]; other site
414684005250	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
414684005251	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
414684005252	active site
414684005253	thymidine kinase; Provisional; Region: PRK04296
414684005254	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
414684005255	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
414684005256	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
414684005257	active site
414684005258	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
414684005259	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
414684005260	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
414684005261	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
414684005262	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
414684005263	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
414684005264	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
414684005265	substrate binding site [chemical binding]; other site
414684005266	oxyanion hole (OAH) forming residues; other site
414684005267	trimer interface [polypeptide binding]; other site
414684005268	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
414684005269	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
414684005270	dimer interface [polypeptide binding]; other site
414684005271	active site
414684005272	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
414684005273	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
414684005274	DNA binding residues [nucleotide binding]
414684005275	putative dimer interface [polypeptide binding]; other site
414684005276	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
414684005277	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
414684005278	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
414684005279	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
414684005280	putative substrate translocation pore; other site
414684005281	POT family; Region: PTR2; cl17359
414684005282	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
414684005283	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
414684005284	substrate binding site [chemical binding]; other site
414684005285	dimer interface [polypeptide binding]; other site
414684005286	ATP binding site [chemical binding]; other site
414684005287	aminopeptidase N; Provisional; Region: pepN; PRK14015
414684005288	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
414684005289	active site
414684005290	Zn binding site [ion binding]; other site
414684005291	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
414684005292	putative ADP-ribose binding site [chemical binding]; other site
414684005293	putative active site [active]
414684005294	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
414684005295	Ligand Binding Site [chemical binding]; other site
414684005296	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
414684005297	Predicted kinase [General function prediction only]; Region: COG0645
414684005298	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
414684005299	active site
414684005300	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
414684005301	BioY family; Region: BioY; pfam02632
414684005302	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
414684005303	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
414684005304	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
414684005305	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
414684005306	rod shape-determining protein MreC; Provisional; Region: PRK13922
414684005307	rod shape-determining protein MreC; Region: MreC; pfam04085
414684005308	rod shape-determining protein MreB; Provisional; Region: PRK13927
414684005309	MreB and similar proteins; Region: MreB_like; cd10225
414684005310	nucleotide binding site [chemical binding]; other site
414684005311	Mg binding site [ion binding]; other site
414684005312	putative protofilament interaction site [polypeptide binding]; other site
414684005313	RodZ interaction site [polypeptide binding]; other site
414684005314	2-isopropylmalate synthase; Validated; Region: PRK00915
414684005315	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
414684005316	active site
414684005317	catalytic residues [active]
414684005318	metal binding site [ion binding]; metal-binding site
414684005319	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
414684005320	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
414684005321	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
414684005322	ketol-acid reductoisomerase; Provisional; Region: PRK05479
414684005323	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
414684005324	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
414684005325	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
414684005326	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
414684005327	putative valine binding site [chemical binding]; other site
414684005328	dimer interface [polypeptide binding]; other site
414684005329	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
414684005330	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
414684005331	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
414684005332	PYR/PP interface [polypeptide binding]; other site
414684005333	dimer interface [polypeptide binding]; other site
414684005334	TPP binding site [chemical binding]; other site
414684005335	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
414684005336	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
414684005337	TPP-binding site [chemical binding]; other site
414684005338	dimer interface [polypeptide binding]; other site
414684005339	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
414684005340	tRNA dimethylallyltransferase; Region: miaA; TIGR00174
414684005341	OpgC protein; Region: OpgC_C; pfam10129
414684005342	phosphoserine phosphatase SerB; Region: serB; TIGR00338
414684005343	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
414684005344	motif II; other site
414684005345	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
414684005346	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
414684005347	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
414684005348	protein binding site [polypeptide binding]; other site
414684005349	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
414684005350	protein binding site [polypeptide binding]; other site
414684005351	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838
414684005352	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
414684005353	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
414684005354	HflK protein; Region: hflK; TIGR01933
414684005355	Domain of unknown function DUF59; Region: DUF59; pfam01883
414684005356	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
414684005357	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
414684005358	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
414684005359	homodimer interface [polypeptide binding]; other site
414684005360	substrate-cofactor binding pocket; other site
414684005361	pyridoxal 5'-phosphate binding site [chemical binding]; other site
414684005362	catalytic residue [active]
414684005363	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
414684005364	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
414684005365	dimer interface [polypeptide binding]; other site
414684005366	pyridoxal 5'-phosphate binding site [chemical binding]; other site
414684005367	catalytic residue [active]
414684005368	FOG: CBS domain [General function prediction only]; Region: COG0517
414684005369	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
414684005370	Protein of unknown function, DUF462; Region: DUF462; cl01190
414684005371	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
414684005372	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
414684005373	folate binding site [chemical binding]; other site
414684005374	NADP+ binding site [chemical binding]; other site
414684005375	Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436
414684005376	Transposase; Region: HTH_Tnp_1; cl17663
414684005377	Killing trait; Region: RebB; pfam11747
414684005378	Killing trait; Region: RebB; pfam11747
414684005379	Killing trait; Region: RebB; pfam11747
414684005380	Killing trait; Region: RebB; pfam11747
414684005381	Killing trait; Region: RebB; pfam11747
414684005382	Killing trait; Region: RebB; pfam11747
414684005383	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
414684005384	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
414684005385	DNA binding residues [nucleotide binding]
414684005386	thymidylate synthase; Reviewed; Region: thyA; PRK01827
414684005387	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
414684005388	dimerization interface [polypeptide binding]; other site
414684005389	active site
414684005390	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814
414684005391	TfoX N-terminal domain; Region: TfoX_N; pfam04993
414684005392	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
414684005393	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
414684005394	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
414684005395	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
414684005396	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
414684005397	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
414684005398	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
414684005399	DNA binding residues [nucleotide binding]
414684005400	DNA primase, catalytic core; Region: dnaG; TIGR01391
414684005401	CHC2 zinc finger; Region: zf-CHC2; cl17510
414684005402	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
414684005403	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
414684005404	active site
414684005405	metal binding site [ion binding]; metal-binding site
414684005406	interdomain interaction site; other site
414684005407	Uncharacterized conserved protein [Function unknown]; Region: COG1610
414684005408	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
414684005409	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
414684005410	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
414684005411	catalytic site [active]
414684005412	subunit interface [polypeptide binding]; other site
414684005413	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
414684005414	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
414684005415	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
414684005416	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
414684005417	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
414684005418	ATP-grasp domain; Region: ATP-grasp_4; cl17255
414684005419	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
414684005420	IMP binding site; other site
414684005421	dimer interface [polypeptide binding]; other site
414684005422	interdomain contacts; other site
414684005423	partial ornithine binding site; other site
414684005424	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
414684005425	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
414684005426	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
414684005427	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
414684005428	Chromate transporter; Region: Chromate_transp; pfam02417
414684005429	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
414684005430	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
414684005431	putative DNA binding site [nucleotide binding]; other site
414684005432	putative Zn2+ binding site [ion binding]; other site
414684005433	AsnC family; Region: AsnC_trans_reg; pfam01037
414684005434	Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660
414684005435	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
414684005436	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
414684005437	Predicted membrane protein [Function unknown]; Region: COG3766
414684005438	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
414684005439	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
414684005440	Protein of unknown function (DUF1190); Region: DUF1190; pfam06693
414684005441	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
414684005442	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
414684005443	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
414684005444	DNA binding residues [nucleotide binding]
414684005445	dimer interface [polypeptide binding]; other site
414684005446	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
414684005447	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
414684005448	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
414684005449	putative active site [active]
414684005450	putative metal binding site [ion binding]; other site
414684005451	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
414684005452	DNA photolyase; Region: DNA_photolyase; pfam00875
414684005453	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
414684005454	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
414684005455	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
414684005456	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
414684005457	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684005458	S-adenosylmethionine binding site [chemical binding]; other site
414684005459	MFS/sugar transport protein; Region: MFS_2; pfam13347
414684005460	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
414684005461	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
414684005462	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
414684005463	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684005464	S-adenosylmethionine binding site [chemical binding]; other site
414684005465	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
414684005466	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
414684005467	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
414684005468	active site
414684005469	oligoendopeptidase F; Region: pepF; TIGR00181
414684005470	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
414684005471	active site
414684005472	Zn binding site [ion binding]; other site
414684005473	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684005474	putative CheW interface [polypeptide binding]; other site
414684005475	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
414684005476	Part of AAA domain; Region: AAA_19; pfam13245
414684005477	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
414684005478	protein-splicing catalytic site; other site
414684005479	thioester formation/cholesterol transfer; other site
414684005480	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
414684005481	protein-splicing catalytic site; other site
414684005482	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
414684005483	Family description; Region: UvrD_C_2; pfam13538
414684005484	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
414684005485	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
414684005486	metal binding site [ion binding]; metal-binding site
414684005487	active site
414684005488	I-site; other site
414684005489	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
414684005490	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
414684005491	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
414684005492	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
414684005493	methionine synt Hase fragment pseudogene
414684005494	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
414684005495	oligomeric interface; other site
414684005496	putative active site [active]
414684005497	homodimer interface [polypeptide binding]; other site
414684005498	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
414684005499	methionine synt Hase fragment pseudogene;identified by match to protein family HMM PF03738
414684005500	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
414684005501	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
414684005502	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684005503	putative active site [active]
414684005504	heme pocket [chemical binding]; other site
414684005505	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
414684005506	Histidine kinase; Region: HisKA_2; pfam07568
414684005507	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684005508	ATP binding site [chemical binding]; other site
414684005509	Mg2+ binding site [ion binding]; other site
414684005510	G-X-G motif; other site
414684005511	Beta/Gamma crystallin; Region: Crystall; cl02528
414684005512	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
414684005513	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
414684005514	FAD binding site [chemical binding]; other site
414684005515	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
414684005516	dimerization interface [polypeptide binding]; other site
414684005517	putative DNA binding site [nucleotide binding]; other site
414684005518	putative Zn2+ binding site [ion binding]; other site
414684005519	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684005520	Methyltransferase domain; Region: Methyltransf_31; pfam13847
414684005521	S-adenosylmethionine binding site [chemical binding]; other site
414684005522	VacJ like lipoprotein; Region: VacJ; cl01073
414684005523	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
414684005524	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
414684005525	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
414684005526	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
414684005527	HlyD family secretion protein; Region: HlyD_3; pfam13437
414684005528	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
414684005529	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
414684005530	Walker A/P-loop; other site
414684005531	ATP binding site [chemical binding]; other site
414684005532	Q-loop/lid; other site
414684005533	ABC transporter signature motif; other site
414684005534	Walker B; other site
414684005535	D-loop; other site
414684005536	H-loop/switch region; other site
414684005537	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
414684005538	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
414684005539	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
414684005540	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
414684005541	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
414684005542	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
414684005543	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
414684005544	ABC transporter; Region: ABC_tran_2; pfam12848
414684005545	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
414684005546	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
414684005547	Predicted membrane protein [Function unknown]; Region: COG3671
414684005548	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
414684005549	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
414684005550	Protein of unknown function (DUF3667); Region: DUF3667; pfam12412
414684005551	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
414684005552	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
414684005553	rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396
414684005554	COQ9; Region: COQ9; pfam08511
414684005555	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
414684005556	active site
414684005557	catalytic residues [active]
414684005558	metal binding site [ion binding]; metal-binding site
414684005559	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
414684005560	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
414684005561	active site
414684005562	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
414684005563	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
414684005564	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
414684005565	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
414684005566	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
414684005567	ligand binding site [chemical binding]; other site
414684005568	homodimer interface [polypeptide binding]; other site
414684005569	NAD(P) binding site [chemical binding]; other site
414684005570	trimer interface B [polypeptide binding]; other site
414684005571	trimer interface A [polypeptide binding]; other site
414684005572	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
414684005573	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
414684005574	active site
414684005575	metal binding site [ion binding]; metal-binding site
414684005576	nudix motif; other site
414684005577	bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566
414684005578	UbiA prenyltransferase family; Region: UbiA; pfam01040
414684005579	PUCC protein; Region: PUCC; pfam03209
414684005580	geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023
414684005581	magnesium chelatase subunit I; Provisional; Region: bchI; PRK13407
414684005582	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
414684005583	magnesium chelatase subunit D; Provisional; Region: bchD; PRK13406
414684005584	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
414684005585	metal ion-dependent adhesion site (MIDAS); other site
414684005586	putative magnesium chelatase accessory protein; Region: bchO_mg_che_rel; TIGR03056
414684005587	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
414684005588	phytoene desaturase; Region: crtI_fam; TIGR02734
414684005589	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
414684005590	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
414684005591	active site lid residues [active]
414684005592	substrate binding pocket [chemical binding]; other site
414684005593	catalytic residues [active]
414684005594	substrate-Mg2+ binding site; other site
414684005595	aspartate-rich region 1; other site
414684005596	aspartate-rich region 2; other site
414684005597	hydroxyneurosporene synt Hase (CrtC), pseudogene;[synonys] Hydroxyneurosporene synt Hase identified by match to protein family HMM PF01327 match to protein family HMM TIGR00079
414684005598	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
414684005599	phytoene desaturase; Region: crtI_fam; TIGR02734
414684005600	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
414684005601	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
414684005602	substrate binding pocket [chemical binding]; other site
414684005603	chain length determination region; other site
414684005604	substrate-Mg2+ binding site; other site
414684005605	catalytic residues [active]
414684005606	aspartate-rich region 1; other site
414684005607	active site lid residues [active]
414684005608	aspartate-rich region 2; other site
414684005609	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684005610	S-adenosylmethionine binding site [chemical binding]; other site
414684005611	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202
414684005612	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
414684005613	putative NAD(P) binding site [chemical binding]; other site
414684005614	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
414684005615	chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016
414684005616	chlorophyllide reductase subunit Y; Region: BchY; TIGR02015
414684005617	Chlide_reductase_Y : Y subunit of chlorophyllide (chlide) reductase (BchY).  Chlide reductase participates in photosynthetic pigment synthesis playing a role in the conversion of chlorophylls(Chl) into bacteriochlorophylls (BChl). Chlide reductase...; Region: Chlide_reductase_Y; cd01980
414684005618	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
414684005619	chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014
414684005620	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
414684005621	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
414684005622	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
414684005623	Subunit L of bacterial photosynthetic reaction center; Region: Photo-RC_L; cd09290
414684005624	subunit M interface; other site
414684005625	subunit H interface; other site
414684005626	quinone binding site; other site
414684005627	bacteriopheophytin binding site; other site
414684005628	bacteriochlorophyll binding site; other site
414684005629	cytochrome C subunit interface; other site
414684005630	Fe binding site [ion binding]; other site
414684005631	Subunit M of bacterial photosynthetic reaction center; Region: Photo-RC_M; cd09291
414684005632	subunit H interface; other site
414684005633	subunit L interface; other site
414684005634	bacteriopheophytin binding site; other site
414684005635	carotenoid binding site; other site
414684005636	bacteriochlorophyll binding site; other site
414684005637	cytochrome C interface; other site
414684005638	quinone binding site; other site
414684005639	Fe binding site [ion binding]; other site
414684005640	Cytochrome C subunit of the bacterial photosynthetic reaction center; Region: CytoC_RC; cd09224
414684005641	subunit interface [polypeptide binding]; other site
414684005642	Heme binding sites [chemical binding]; other site
414684005643	Cytochrome c; Region: Cytochrom_C; cl11414
414684005644	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
414684005645	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
414684005646	substrate-cofactor binding pocket; other site
414684005647	pyridoxal 5'-phosphate binding site [chemical binding]; other site
414684005648	catalytic residue [active]
414684005649	Protein of unknown function (DUF3623); Region: DUF3623; pfam12291
414684005650	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
414684005651	diiron binding motif [ion binding]; other site
414684005652	putative photosynthetic complex assembly protein; Region: photo_alph_chp1; TIGR03054
414684005653	Bacterial PH domain; Region: DUF304; cl01348
414684005654	photosynthetic reaction center, subunit H, bacterial; Region: puhA; TIGR01150
414684005655	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl17581
414684005656	subunit C interaction residues; other site
414684005657	subunit M interaction residues [polypeptide binding]; other site
414684005658	subunit L interaction residues [polypeptide binding]; other site
414684005659	putative proton transfer pathway, P1; other site
414684005660	putative proton transfer pathway, P2; other site
414684005661	PUCC protein; Region: PUCC; pfam03209
414684005662	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
414684005663	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684005664	S-adenosylmethionine binding site [chemical binding]; other site
414684005665	Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
414684005666	protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185
414684005667	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
414684005668	P-loop; other site
414684005669	magnesium chelatase subunit H; Provisional; Region: bchH; PRK13405
414684005670	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
414684005671	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
414684005672	light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910
414684005673	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
414684005674	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
414684005675	light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842
414684005676	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
414684005677	2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284
414684005678	B12 binding domain; Region: B12-binding_2; pfam02607
414684005679	B12 binding domain; Region: B12-binding; pfam02310
414684005680	B12 binding site [chemical binding]; other site
414684005681	transcriptional regulator PpsR; Region: PpsR-CrtJ; TIGR02040
414684005682	PAS domain; Region: PAS_8; pfam13188
414684005683	putative active site [active]
414684005684	heme pocket [chemical binding]; other site
414684005685	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684005686	putative active site [active]
414684005687	heme pocket [chemical binding]; other site
414684005688	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
414684005689	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
414684005690	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
414684005691	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
414684005692	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
414684005693	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
414684005694	catalytic site [active]
414684005695	active site
414684005696	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
414684005697	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
414684005698	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
414684005699	Protein of unknown function (DUF1428); Region: DUF1428; cl02319
414684005700	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048
414684005701	diiron binding motif [ion binding]; other site
414684005702	DEAD-like helicases superfamily; Region: DEXDc; smart00487
414684005703	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
414684005704	nucleotide binding region [chemical binding]; other site
414684005705	ATP-binding site [chemical binding]; other site
414684005706	Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513
414684005707	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
414684005708	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684005709	active site
414684005710	phosphorylation site [posttranslational modification]
414684005711	intermolecular recognition site; other site
414684005712	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684005713	phosphorylation site [posttranslational modification]
414684005714	intermolecular recognition site; other site
414684005715	PAS domain S-box; Region: sensory_box; TIGR00229
414684005716	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
414684005717	HWE histidine kinase; Region: HWE_HK; pfam07536
414684005718	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
414684005719	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684005720	active site
414684005721	phosphorylation site [posttranslational modification]
414684005722	intermolecular recognition site; other site
414684005723	dimerization interface [polypeptide binding]; other site
414684005724	CheB methylesterase; Region: CheB_methylest; pfam01339
414684005725	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
414684005726	putative binding surface; other site
414684005727	active site
414684005728	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684005729	ATP binding site [chemical binding]; other site
414684005730	Mg2+ binding site [ion binding]; other site
414684005731	G-X-G motif; other site
414684005732	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
414684005733	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
414684005734	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684005735	active site
414684005736	phosphorylation site [posttranslational modification]
414684005737	intermolecular recognition site; other site
414684005738	dimerization interface [polypeptide binding]; other site
414684005739	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
414684005740	dimerization interface [polypeptide binding]; other site
414684005741	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
414684005742	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684005743	dimer interface [polypeptide binding]; other site
414684005744	putative CheW interface [polypeptide binding]; other site
414684005745	CheW-like domain; Region: CheW; pfam01584
414684005746	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
414684005747	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
414684005748	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
414684005749	CheW-like domain; Region: CheW; pfam01584
414684005750	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
414684005751	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
414684005752	ABC1 family; Region: ABC1; pfam03109
414684005753	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
414684005754	active site
414684005755	ATP binding site [chemical binding]; other site
414684005756	pyruvate kinase; Provisional; Region: PRK06247
414684005757	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
414684005758	domain interfaces; other site
414684005759	active site
414684005760	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
414684005761	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
414684005762	MOFRL family; Region: MOFRL; pfam05161
414684005763	N-formylglutamate amidohydrolase; Region: FGase; cl01522
414684005764	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492
414684005765	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
414684005766	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
414684005767	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
414684005768	active site
414684005769	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
414684005770	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
414684005771	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
414684005772	[2Fe-2S] cluster binding site [ion binding]; other site
414684005773	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
414684005774	hydrophobic ligand binding site; other site
414684005775	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
414684005776	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
414684005777	active site
414684005778	Zn binding site [ion binding]; other site
414684005779	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684005780	active site
414684005781	phosphorylation site [posttranslational modification]
414684005782	intermolecular recognition site; other site
414684005783	dimerization interface [polypeptide binding]; other site
414684005784	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
414684005785	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
414684005786	ligand binding site [chemical binding]; other site
414684005787	flexible hinge region; other site
414684005788	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
414684005789	non-specific DNA interactions [nucleotide binding]; other site
414684005790	DNA binding site [nucleotide binding]
414684005791	sequence specific DNA binding site [nucleotide binding]; other site
414684005792	putative cAMP binding site [chemical binding]; other site
414684005793	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
414684005794	Cysteine-rich domain; Region: CCG; pfam02754
414684005795	Cysteine-rich domain; Region: CCG; pfam02754
414684005796	Protein of unknown function, DUF393; Region: DUF393; pfam04134
414684005797	FAD binding domain; Region: FAD_binding_4; pfam01565
414684005798	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
414684005799	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
414684005800	FAD binding domain; Region: FAD_binding_4; pfam01565
414684005801	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
414684005802	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
414684005803	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
414684005804	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
414684005805	protein binding site [polypeptide binding]; other site
414684005806	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
414684005807	Methyltransferase domain; Region: Methyltransf_23; pfam13489
414684005808	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684005809	S-adenosylmethionine binding site [chemical binding]; other site
414684005810	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
414684005811	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684005812	active site
414684005813	phosphorylation site [posttranslational modification]
414684005814	intermolecular recognition site; other site
414684005815	dimerization interface [polypeptide binding]; other site
414684005816	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
414684005817	Walker A motif; other site
414684005818	ATP binding site [chemical binding]; other site
414684005819	Walker B motif; other site
414684005820	arginine finger; other site
414684005821	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
414684005822	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
414684005823	Methyltransferase domain; Region: Methyltransf_23; pfam13489
414684005824	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684005825	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
414684005826	DNA-binding site [nucleotide binding]; DNA binding site
414684005827	RNA-binding motif; other site
414684005828	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
414684005829	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
414684005830	Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219
414684005831	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
414684005832	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
414684005833	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
414684005834	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
414684005835	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
414684005836	catalytic triad [active]
414684005837	Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224
414684005838	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
414684005839	Domain of unknown function (DUF4383); Region: DUF4383; pfam14325
414684005840	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
414684005841	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
414684005842	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
414684005843	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
414684005844	DNA binding residues [nucleotide binding]
414684005845	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516
414684005846	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
414684005847	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
414684005848	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
414684005849	tetramer interface [polypeptide binding]; other site
414684005850	heme binding pocket [chemical binding]; other site
414684005851	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
414684005852	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684005853	dimer interface [polypeptide binding]; other site
414684005854	putative CheW interface [polypeptide binding]; other site
414684005855	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
414684005856	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
414684005857	FAD binding pocket [chemical binding]; other site
414684005858	FAD binding motif [chemical binding]; other site
414684005859	phosphate binding motif [ion binding]; other site
414684005860	beta-alpha-beta structure motif; other site
414684005861	NAD binding pocket [chemical binding]; other site
414684005862	siroheme synthase; Provisional; Region: cysG; PRK10637
414684005863	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
414684005864	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
414684005865	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
414684005866	active site
414684005867	SAM binding site [chemical binding]; other site
414684005868	homodimer interface [polypeptide binding]; other site
414684005869	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
414684005870	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
414684005871	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
414684005872	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
414684005873	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
414684005874	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
414684005875	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
414684005876	Active Sites [active]
414684005877	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
414684005878	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
414684005879	Active Sites [active]
414684005880	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
414684005881	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
414684005882	CysD dimerization site [polypeptide binding]; other site
414684005883	G1 box; other site
414684005884	putative GEF interaction site [polypeptide binding]; other site
414684005885	GTP/Mg2+ binding site [chemical binding]; other site
414684005886	Switch I region; other site
414684005887	G2 box; other site
414684005888	G3 box; other site
414684005889	Switch II region; other site
414684005890	G4 box; other site
414684005891	G5 box; other site
414684005892	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
414684005893	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
414684005894	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
414684005895	ligand-binding site [chemical binding]; other site
414684005896	PAS domain; Region: PAS_5; pfam07310
414684005897	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388
414684005898	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
414684005899	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
414684005900	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
414684005901	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
414684005902	active site
414684005903	Zn binding site [ion binding]; other site
414684005904	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
414684005905	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
414684005906	CoA-ligase; Region: Ligase_CoA; pfam00549
414684005907	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
414684005908	CoA binding domain; Region: CoA_binding; pfam02629
414684005909	CoA-ligase; Region: Ligase_CoA; pfam00549
414684005910	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
414684005911	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
414684005912	Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029
414684005913	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
414684005914	ApbE family; Region: ApbE; pfam02424
414684005915	Sensors of blue-light using FAD; Region: BLUF; pfam04940
414684005916	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
414684005917	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
414684005918	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
414684005919	P loop; other site
414684005920	GTP binding site [chemical binding]; other site
414684005921	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
414684005922	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
414684005923	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
414684005924	FeS/SAM binding site; other site
414684005925	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
414684005926	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
414684005927	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
414684005928	serine acetyltransferase; Provisional; Region: cysE; PRK11132
414684005929	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
414684005930	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
414684005931	trimer interface [polypeptide binding]; other site
414684005932	active site
414684005933	substrate binding site [chemical binding]; other site
414684005934	CoA binding site [chemical binding]; other site
414684005935	GtrA-like protein; Region: GtrA; pfam04138
414684005936	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
414684005937	Ligand binding site; other site
414684005938	Putative Catalytic site; other site
414684005939	DXD motif; other site
414684005940	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
414684005941	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
414684005942	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
414684005943	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
414684005944	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
414684005945	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
414684005946	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
414684005947	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
414684005948	signal recognition particle protein; Provisional; Region: PRK10867
414684005949	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
414684005950	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
414684005951	P loop; other site
414684005952	GTP binding site [chemical binding]; other site
414684005953	Signal peptide binding domain; Region: SRP_SPB; pfam02978
414684005954	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
414684005955	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
414684005956	Coenzyme A binding pocket [chemical binding]; other site
414684005957	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
414684005958	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
414684005959	RimM N-terminal domain; Region: RimM; pfam01782
414684005960	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828
414684005961	PRC-barrel domain; Region: PRC; pfam05239
414684005962	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
414684005963	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
414684005964	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
414684005965	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
414684005966	peptide binding site [polypeptide binding]; other site
414684005967	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
414684005968	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
414684005969	peptide binding site [polypeptide binding]; other site
414684005970	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
414684005971	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
414684005972	peptide binding site [polypeptide binding]; other site
414684005973	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
414684005974	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
414684005975	peptide binding site [polypeptide binding]; other site
414684005976	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
414684005977	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
414684005978	peptide binding site [polypeptide binding]; other site
414684005979	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
414684005980	ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148
414684005981	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
414684005982	Walker A/P-loop; other site
414684005983	ATP binding site [chemical binding]; other site
414684005984	Q-loop/lid; other site
414684005985	ABC transporter signature motif; other site
414684005986	Walker B; other site
414684005987	D-loop; other site
414684005988	H-loop/switch region; other site
414684005989	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
414684005990	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
414684005991	dimer interface [polypeptide binding]; other site
414684005992	conserved gate region; other site
414684005993	putative PBP binding loops; other site
414684005994	ABC-ATPase subunit interface; other site
414684005995	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
414684005996	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
414684005997	Protein of unknown function (DUF938); Region: DUF938; pfam06080
414684005998	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
414684005999	putative metal binding site [ion binding]; other site
414684006000	Ferredoxin [Energy production and conversion]; Region: COG1146
414684006001	4Fe-4S binding domain; Region: Fer4; cl02805
414684006002	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
414684006003	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
414684006004	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
414684006005	active site
414684006006	metal binding site [ion binding]; metal-binding site
414684006007	RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500
414684006008	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
414684006009	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
414684006010	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
414684006011	DNA binding residues [nucleotide binding]
414684006012	Cache domain; Region: Cache_1; pfam02743
414684006013	HAMP domain; Region: HAMP; pfam00672
414684006014	dimerization interface [polypeptide binding]; other site
414684006015	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
414684006016	cyclase homology domain; Region: CHD; cd07302
414684006017	nucleotidyl binding site; other site
414684006018	metal binding site [ion binding]; metal-binding site
414684006019	dimer interface [polypeptide binding]; other site
414684006020	Putative Zn-dependent protease [General function prediction only]; Region: COG4784
414684006021	Peptidase family M48; Region: Peptidase_M48; pfam01435
414684006022	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
414684006023	heme-binding site [chemical binding]; other site
414684006024	NnrU protein; Region: NnrU; cl17713
414684006025	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
414684006026	TAP-like protein; Region: Abhydrolase_4; pfam08386
414684006027	potassium/proton antiporter; Reviewed; Region: PRK05326
414684006028	TrkA-C domain; Region: TrkA_C; pfam02080
414684006029	Transporter associated domain; Region: CorC_HlyC; smart01091
414684006030	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
414684006031	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
414684006032	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
414684006033	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
414684006034	putative NADH binding site [chemical binding]; other site
414684006035	putative active site [active]
414684006036	nudix motif; other site
414684006037	putative metal binding site [ion binding]; other site
414684006038	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
414684006039	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
414684006040	dinuclear metal binding motif [ion binding]; other site
414684006041	F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355
414684006042	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
414684006043	gamma subunit interface [polypeptide binding]; other site
414684006044	epsilon subunit interface [polypeptide binding]; other site
414684006045	LBP interface [polypeptide binding]; other site
414684006046	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
414684006047	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
414684006048	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
414684006049	alpha subunit interaction interface [polypeptide binding]; other site
414684006050	Walker A motif; other site
414684006051	ATP binding site [chemical binding]; other site
414684006052	Walker B motif; other site
414684006053	inhibitor binding site; inhibition site
414684006054	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
414684006055	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
414684006056	core domain interface [polypeptide binding]; other site
414684006057	delta subunit interface [polypeptide binding]; other site
414684006058	epsilon subunit interface [polypeptide binding]; other site
414684006059	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
414684006060	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
414684006061	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
414684006062	beta subunit interaction interface [polypeptide binding]; other site
414684006063	Walker A motif; other site
414684006064	ATP binding site [chemical binding]; other site
414684006065	Walker B motif; other site
414684006066	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
414684006067	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
414684006068	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
414684006069	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
414684006070	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
414684006071	active site
414684006072	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
414684006073	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
414684006074	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
414684006075	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
414684006076	putative active site [active]
414684006077	putative metal binding site [ion binding]; other site
414684006078	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
414684006079	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
414684006080	DinB family; Region: DinB; cl17821
414684006081	primosome assembly protein PriA; Validated; Region: PRK05580
414684006082	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
414684006083	ATP binding site [chemical binding]; other site
414684006084	putative Mg++ binding site [ion binding]; other site
414684006085	helicase superfamily c-terminal domain; Region: HELICc; smart00490
414684006086	nucleotide binding region [chemical binding]; other site
414684006087	ATP-binding site [chemical binding]; other site
414684006088	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
414684006089	non-specific DNA binding site [nucleotide binding]; other site
414684006090	salt bridge; other site
414684006091	sequence-specific DNA binding site [nucleotide binding]; other site
414684006092	Protein of unknown function (DUF497); Region: DUF497; pfam04365
414684006093	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
414684006094	active site
414684006095	intersubunit interactions; other site
414684006096	catalytic residue [active]
414684006097	Protein of unknown function, DUF484; Region: DUF484; cl17449
414684006098	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
414684006099	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
414684006100	active site
414684006101	DNA binding site [nucleotide binding]
414684006102	Int/Topo IB signature motif; other site
414684006103	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
414684006104	sequence-specific DNA binding site [nucleotide binding]; other site
414684006105	salt bridge; other site
414684006106	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
414684006107	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
414684006108	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
414684006109	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
414684006110	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684006111	dimer interface [polypeptide binding]; other site
414684006112	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
414684006113	putative CheW interface [polypeptide binding]; other site
414684006114	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684006115	dimer interface [polypeptide binding]; other site
414684006116	phosphorylation site [posttranslational modification]
414684006117	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684006118	ATP binding site [chemical binding]; other site
414684006119	Mg2+ binding site [ion binding]; other site
414684006120	G-X-G motif; other site
414684006121	Response regulator receiver domain; Region: Response_reg; pfam00072
414684006122	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684006123	active site
414684006124	phosphorylation site [posttranslational modification]
414684006125	intermolecular recognition site; other site
414684006126	dimerization interface [polypeptide binding]; other site
414684006127	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
414684006128	E3 interaction surface; other site
414684006129	lipoyl attachment site [posttranslational modification]; other site
414684006130	e3 binding domain; Region: E3_binding; pfam02817
414684006131	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
414684006132	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
414684006133	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
414684006134	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
414684006135	TPP-binding site [chemical binding]; other site
414684006136	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
414684006137	dimer interface [polypeptide binding]; other site
414684006138	PYR/PP interface [polypeptide binding]; other site
414684006139	TPP binding site [chemical binding]; other site
414684006140	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
414684006141	active site
414684006142	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
414684006143	active site
414684006144	catalytic motif [active]
414684006145	Zn binding site [ion binding]; other site
414684006146	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
414684006147	intersubunit interface [polypeptide binding]; other site
414684006148	active site
414684006149	catalytic residue [active]
414684006150	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
414684006151	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
414684006152	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
414684006153	active site
414684006154	catalytic site [active]
414684006155	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684006156	Response regulator receiver domain; Region: Response_reg; pfam00072
414684006157	active site
414684006158	phosphorylation site [posttranslational modification]
414684006159	intermolecular recognition site; other site
414684006160	dimerization interface [polypeptide binding]; other site
414684006161	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
414684006162	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
414684006163	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
414684006164	active site
414684006165	catalytic site [active]
414684006166	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
414684006167	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
414684006168	EamA-like transporter family; Region: EamA; cl17759
414684006169	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
414684006170	tetramerization interface [polypeptide binding]; other site
414684006171	active site
414684006172	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
414684006173	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
414684006174	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
414684006175	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734
414684006176	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
414684006177	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
414684006178	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684006179	S-adenosylmethionine binding site [chemical binding]; other site
414684006180	mercuric reductase; Validated; Region: PRK06370
414684006181	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
414684006182	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
414684006183	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
414684006184	Uncharacterized conserved protein [Function unknown]; Region: COG0398
414684006185	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
414684006186	Ribonuclease P; Region: Ribonuclease_P; pfam00825
414684006187	membrane protein insertase; Provisional; Region: PRK01318
414684006188	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
414684006189	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
414684006190	G1 box; other site
414684006191	GTP/Mg2+ binding site [chemical binding]; other site
414684006192	Switch I region; other site
414684006193	G2 box; other site
414684006194	G3 box; other site
414684006195	Switch II region; other site
414684006196	G4 box; other site
414684006197	G5 box; other site
414684006198	TAP-like protein; Region: Abhydrolase_4; pfam08386
414684006199	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
414684006200	feedback inhibition sensing region; other site
414684006201	homohexameric interface [polypeptide binding]; other site
414684006202	nucleotide binding site [chemical binding]; other site
414684006203	N-acetyl-L-glutamate binding site [chemical binding]; other site
414684006204	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
414684006205	PAS domain S-box; Region: sensory_box; TIGR00229
414684006206	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684006207	putative active site [active]
414684006208	heme pocket [chemical binding]; other site
414684006209	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
414684006210	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
414684006211	metal binding site [ion binding]; metal-binding site
414684006212	active site
414684006213	I-site; other site
414684006214	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
414684006215	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
414684006216	motif II; other site
414684006217	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
414684006218	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
414684006219	trimer interface [polypeptide binding]; other site
414684006220	active site
414684006221	substrate binding site [chemical binding]; other site
414684006222	CoA binding site [chemical binding]; other site
414684006223	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
414684006224	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
414684006225	metal binding site [ion binding]; metal-binding site
414684006226	dimer interface [polypeptide binding]; other site
414684006227	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
414684006228	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
414684006229	dimerization interface 3.5A [polypeptide binding]; other site
414684006230	active site
414684006231	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
414684006232	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
414684006233	putative active site [active]
414684006234	substrate binding site [chemical binding]; other site
414684006235	putative cosubstrate binding site; other site
414684006236	catalytic site [active]
414684006237	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
414684006238	substrate binding site [chemical binding]; other site
414684006239	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
414684006240	active site
414684006241	catalytic residues [active]
414684006242	metal binding site [ion binding]; metal-binding site
414684006243	RmuC family; Region: RmuC; pfam02646
414684006244	HEPN domain; Region: HEPN; pfam05168
414684006245	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
414684006246	active site
414684006247	NTP binding site [chemical binding]; other site
414684006248	metal binding triad [ion binding]; metal-binding site
414684006249	antibiotic binding site [chemical binding]; other site
414684006250	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
414684006251	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
414684006252	NAD(P) binding site [chemical binding]; other site
414684006253	active site
414684006254	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
414684006255	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
414684006256	recombination protein RecR; Reviewed; Region: recR; PRK00076
414684006257	RecR protein; Region: RecR; pfam02132
414684006258	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
414684006259	putative active site [active]
414684006260	putative metal-binding site [ion binding]; other site
414684006261	tetramer interface [polypeptide binding]; other site
414684006262	hypothetical protein; Validated; Region: PRK00153
414684006263	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
414684006264	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
414684006265	Walker A motif; other site
414684006266	ATP binding site [chemical binding]; other site
414684006267	Walker B motif; other site
414684006268	arginine finger; other site
414684006269	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
414684006270	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
414684006271	Protein of unknown function, DUF488; Region: DUF488; pfam04343
414684006272	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
414684006273	PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821
414684006274	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
414684006275	PA/protease or protease-like domain interface [polypeptide binding]; other site
414684006276	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660
414684006277	metal binding site [ion binding]; metal-binding site
414684006278	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
414684006279	PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821
414684006280	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
414684006281	PA/protease or protease-like domain interface [polypeptide binding]; other site
414684006282	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660
414684006283	metal binding site [ion binding]; metal-binding site
414684006284	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
414684006285	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
414684006286	23S rRNA binding site [nucleotide binding]; other site
414684006287	L21 binding site [polypeptide binding]; other site
414684006288	L13 binding site [polypeptide binding]; other site
414684006289	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
414684006290	putative active site [active]
414684006291	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
414684006292	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
414684006293	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
414684006294	dimer interface [polypeptide binding]; other site
414684006295	motif 1; other site
414684006296	active site
414684006297	motif 2; other site
414684006298	motif 3; other site
414684006299	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
414684006300	PemK-like protein; Region: PemK; pfam02452
414684006301	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
414684006302	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
414684006303	putative tRNA-binding site [nucleotide binding]; other site
414684006304	B3/4 domain; Region: B3_4; pfam03483
414684006305	tRNA synthetase B5 domain; Region: B5; smart00874
414684006306	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
414684006307	dimer interface [polypeptide binding]; other site
414684006308	motif 3; other site
414684006309	motif 2; other site
414684006310	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
414684006311	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
414684006312	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
414684006313	dimerization interface [polypeptide binding]; other site
414684006314	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684006315	dimer interface [polypeptide binding]; other site
414684006316	putative CheW interface [polypeptide binding]; other site
414684006317	Acyltransferase family; Region: Acyl_transf_3; pfam01757
414684006318	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
414684006319	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
414684006320	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
414684006321	Peptidase S46; Region: Peptidase_S46; pfam10459
414684006322	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
414684006323	maleylacetoacetate isomerase; Region: maiA; TIGR01262
414684006324	Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417
414684006325	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
414684006326	N-terminal domain interface [polypeptide binding]; other site
414684006327	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388
414684006328	malonyl-CoA synthase; Validated; Region: PRK07514
414684006329	Malonyl-CoA synthetase (MCS); Region: MCS; cd05941
414684006330	acyl-activating enzyme (AAE) consensus motif; other site
414684006331	active site
414684006332	AMP binding site [chemical binding]; other site
414684006333	CoA binding site [chemical binding]; other site
414684006334	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
414684006335	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
414684006336	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
414684006337	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
414684006338	putative C-terminal domain interface [polypeptide binding]; other site
414684006339	putative GSH binding site (G-site) [chemical binding]; other site
414684006340	putative dimer interface [polypeptide binding]; other site
414684006341	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
414684006342	putative substrate binding pocket (H-site) [chemical binding]; other site
414684006343	putative N-terminal domain interface [polypeptide binding]; other site
414684006344	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
414684006345	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
414684006346	interface (dimer of trimers) [polypeptide binding]; other site
414684006347	Substrate-binding/catalytic site; other site
414684006348	Zn-binding sites [ion binding]; other site
414684006349	Transcriptional regulators [Transcription]; Region: MarR; COG1846
414684006350	MarR family; Region: MarR; pfam01047
414684006351	Src Homology 3 domain superfamily; Region: SH3; cl17036
414684006352	peptide ligand binding site [polypeptide binding]; other site
414684006353	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
414684006354	NlpC/P60 family; Region: NLPC_P60; cl17555
414684006355	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
414684006356	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
414684006357	substrate binding site [chemical binding]; other site
414684006358	ligand binding site [chemical binding]; other site
414684006359	methyl-accepting chemotaxis protein, pseudogene;identified by match to protein family HMM PF05685
414684006360	acetyl-CoA synthetase; Provisional; Region: PRK00174
414684006361	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
414684006362	active site
414684006363	CoA binding site [chemical binding]; other site
414684006364	acyl-activating enzyme (AAE) consensus motif; other site
414684006365	AMP binding site [chemical binding]; other site
414684006366	acetate binding site [chemical binding]; other site
414684006367	Transposase domain (DUF772); Region: DUF772; pfam05598
414684006368	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
414684006369	TIGR02680 family protein; Region: TIGR02680
414684006370	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
414684006371	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
414684006372	ligand binding site [chemical binding]; other site
414684006373	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
414684006374	Catalytic site; other site
414684006375	Uncharacterized conserved small protein [Function unknown]; Region: COG5508
414684006376	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
414684006377	heat shock protein HtpX; Provisional; Region: PRK01345
414684006378	16S rRNA methyltransferase B; Provisional; Region: PRK10901
414684006379	NusB family; Region: NusB; pfam01029
414684006380	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684006381	S-adenosylmethionine binding site [chemical binding]; other site
414684006382	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
414684006383	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
414684006384	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
414684006385	substrate binding site [chemical binding]; other site
414684006386	hexamer interface [polypeptide binding]; other site
414684006387	metal binding site [ion binding]; metal-binding site
414684006388	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
414684006389	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
414684006390	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
414684006391	purine monophosphate binding site [chemical binding]; other site
414684006392	dimer interface [polypeptide binding]; other site
414684006393	putative catalytic residues [active]
414684006394	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
414684006395	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
414684006396	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
414684006397	nudix motif; other site
414684006398	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
414684006399	iron-sulfur cluster [ion binding]; other site
414684006400	[2Fe-2S] cluster binding site [ion binding]; other site
414684006401	EVE domain; Region: EVE; pfam01878
414684006402	YciI-like protein; Reviewed; Region: PRK12863
414684006403	BON domain; Region: BON; pfam04972
414684006404	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
414684006405	active site
414684006406	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
414684006407	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
414684006408	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
414684006409	UGMP family protein; Validated; Region: PRK09604
414684006410	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
414684006411	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
414684006412	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
414684006413	domain interfaces; other site
414684006414	active site
414684006415	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
414684006416	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
414684006417	active site
414684006418	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223
414684006419	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
414684006420	HemY protein N-terminus; Region: HemY_N; pfam07219
414684006421	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
414684006422	CobD/Cbib protein; Region: CobD_Cbib; cl00561
414684006423	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
414684006424	putative amphipathic alpha helix; other site
414684006425	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
414684006426	cobalamin synthase; Reviewed; Region: cobS; PRK00235
414684006427	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
414684006428	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
414684006429	putative dimer interface [polypeptide binding]; other site
414684006430	active site pocket [active]
414684006431	putative cataytic base [active]
414684006432	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
414684006433	Disaggregatase related; Region: Disaggr_assoc; pfam08480
414684006434	Right handed beta helix region; Region: Beta_helix; pfam13229
414684006435	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
414684006436	dimer interface [polypeptide binding]; other site
414684006437	putative tRNA-binding site [nucleotide binding]; other site
414684006438	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
414684006439	GTP cyclohydrolase I; Provisional; Region: PLN03044
414684006440	active site
414684006441	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
414684006442	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
414684006443	Coenzyme A binding pocket [chemical binding]; other site
414684006444	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
414684006445	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
414684006446	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
414684006447	ABC transporter; Region: ABC_tran_2; pfam12848
414684006448	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
414684006449	Protein of unknown function (DUF3620); Region: DUF3620; cl02233
414684006450	HipA N-terminal domain; Region: Couple_hipA; cl11853
414684006451	HipA-like N-terminal domain; Region: HipA_N; pfam07805
414684006452	HipA-like C-terminal domain; Region: HipA_C; pfam07804
414684006453	Transposase domain (DUF772); Region: DUF772; pfam05598
414684006454	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
414684006455	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
414684006456	Putative phosphatase (DUF442); Region: DUF442; cl17385
414684006457	Fic family protein [Function unknown]; Region: COG3177
414684006458	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
414684006459	Fic/DOC family; Region: Fic; pfam02661
414684006460	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
414684006461	putative DNA binding site [nucleotide binding]; other site
414684006462	Transposase; Region: DDE_Tnp_ISL3; pfam01610
414684006463	Transposase; Region: DDE_Tnp_ISL3; pfam01610
414684006464	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
414684006465	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
414684006466	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
414684006467	PhoD-like phosphatase; Region: PhoD; pfam09423
414684006468	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
414684006469	putative active site [active]
414684006470	putative metal binding site [ion binding]; other site
414684006471	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
414684006472	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
414684006473	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
414684006474	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
414684006475	IHF dimer interface [polypeptide binding]; other site
414684006476	IHF - DNA interface [nucleotide binding]; other site
414684006477	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
414684006478	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
414684006479	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
414684006480	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388
414684006481	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
414684006482	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684006483	active site
414684006484	phosphorylation site [posttranslational modification]
414684006485	intermolecular recognition site; other site
414684006486	dimerization interface [polypeptide binding]; other site
414684006487	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684006488	PAS fold; Region: PAS_3; pfam08447
414684006489	putative active site [active]
414684006490	heme pocket [chemical binding]; other site
414684006491	PAS domain; Region: PAS_9; pfam13426
414684006492	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
414684006493	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
414684006494	HWE histidine kinase; Region: HWE_HK; pfam07536
414684006495	pyruvate kinase; Validated; Region: PRK08187
414684006496	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
414684006497	domain interfaces; other site
414684006498	active site
414684006499	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
414684006500	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
414684006501	GTP-binding protein LepA; Provisional; Region: PRK05433
414684006502	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
414684006503	G1 box; other site
414684006504	putative GEF interaction site [polypeptide binding]; other site
414684006505	GTP/Mg2+ binding site [chemical binding]; other site
414684006506	Switch I region; other site
414684006507	G2 box; other site
414684006508	G3 box; other site
414684006509	Switch II region; other site
414684006510	G4 box; other site
414684006511	G5 box; other site
414684006512	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
414684006513	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
414684006514	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
414684006515	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
414684006516	NAD(P) binding site [chemical binding]; other site
414684006517	active site
414684006518	Uncharacterized conserved protein [Function unknown]; Region: COG3339
414684006519	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
414684006520	EamA-like transporter family; Region: EamA; pfam00892
414684006521	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
414684006522	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
414684006523	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
414684006524	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
414684006525	P-loop; other site
414684006526	Magnesium ion binding site [ion binding]; other site
414684006527	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
414684006528	Uncharacterized conserved protein [Function unknown]; Region: COG3025
414684006529	putative active site [active]
414684006530	putative triphosphate binding site [ion binding]; other site
414684006531	putative metal binding residues [ion binding]; other site
414684006532	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
414684006533	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
414684006534	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
414684006535	Methyltransferase domain; Region: Methyltransf_23; pfam13489
414684006536	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684006537	S-adenosylmethionine binding site [chemical binding]; other site
414684006538	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
414684006539	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
414684006540	Bacterial transcriptional repressor; Region: TetR; pfam13972
414684006541	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
414684006542	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
414684006543	RNA binding surface [nucleotide binding]; other site
414684006544	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
414684006545	ATP binding site [chemical binding]; other site
414684006546	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
414684006547	putative Mg++ binding site [ion binding]; other site
414684006548	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
414684006549	nucleotide binding region [chemical binding]; other site
414684006550	ATP-binding site [chemical binding]; other site
414684006551	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
414684006552	non-specific DNA binding site [nucleotide binding]; other site
414684006553	salt bridge; other site
414684006554	sequence-specific DNA binding site [nucleotide binding]; other site
414684006555	phage-related protein, pseudogene;identified by match to protein family HMM PF00224 match to protein family HMM PF03328
414684006556	heat shock protein 90; Provisional; Region: PRK05218
414684006557	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684006558	ATP binding site [chemical binding]; other site
414684006559	Mg2+ binding site [ion binding]; other site
414684006560	G-X-G motif; other site
414684006561	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
414684006562	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
414684006563	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
414684006564	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
414684006565	Peptidase M15; Region: Peptidase_M15_3; cl01194
414684006566	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
414684006567	NRDE protein; Region: NRDE; cl01315
414684006568	Domain of unknown function (DUF1476); Region: DUF1476; pfam07345
414684006569	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
414684006570	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
414684006571	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
414684006572	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
414684006573	ATP binding site [chemical binding]; other site
414684006574	putative Mg++ binding site [ion binding]; other site
414684006575	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
414684006576	nucleotide binding region [chemical binding]; other site
414684006577	ATP-binding site [chemical binding]; other site
414684006578	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
414684006579	HRDC domain; Region: HRDC; pfam00570
414684006580	Helix-turn-helix domain; Region: HTH_37; pfam13744
414684006581	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
414684006582	transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309
414684006583	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
414684006584	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
414684006585	HlyD family secretion protein; Region: HlyD_3; pfam13437
414684006586	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
414684006587	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
414684006588	Walker A/P-loop; other site
414684006589	ATP binding site [chemical binding]; other site
414684006590	Q-loop/lid; other site
414684006591	ABC transporter signature motif; other site
414684006592	Walker B; other site
414684006593	D-loop; other site
414684006594	H-loop/switch region; other site
414684006595	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
414684006596	FtsX-like permease family; Region: FtsX; pfam02687
414684006597	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
414684006598	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
414684006599	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
414684006600	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
414684006601	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
414684006602	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
414684006603	motif II; other site
414684006604	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
414684006605	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
414684006606	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
414684006607	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
414684006608	ligand binding site [chemical binding]; other site
414684006609	flexible hinge region; other site
414684006610	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
414684006611	Ligand Binding Site [chemical binding]; other site
414684006612	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
414684006613	Ligand Binding Site [chemical binding]; other site
414684006614	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
414684006615	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
414684006616	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
414684006617	[2Fe-2S] cluster binding site [ion binding]; other site
414684006618	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
414684006619	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
414684006620	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
414684006621	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
414684006622	G1 box; other site
414684006623	GTP/Mg2+ binding site [chemical binding]; other site
414684006624	Switch I region; other site
414684006625	G2 box; other site
414684006626	G3 box; other site
414684006627	Switch II region; other site
414684006628	G4 box; other site
414684006629	G5 box; other site
414684006630	Nucleoside recognition; Region: Gate; pfam07670
414684006631	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
414684006632	Nucleoside recognition; Region: Gate; pfam07670
414684006633	FeoA domain; Region: FeoA; pfam04023
414684006634	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
414684006635	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
414684006636	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
414684006637	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
414684006638	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
414684006639	active site
414684006640	tetramer interface [polypeptide binding]; other site
414684006641	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
414684006642	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
414684006643	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
414684006644	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
414684006645	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
414684006646	intersubunit interface [polypeptide binding]; other site
414684006647	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
414684006648	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
414684006649	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
414684006650	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
414684006651	dimer interface [polypeptide binding]; other site
414684006652	putative PBP binding regions; other site
414684006653	ABC-ATPase subunit  interface; other site
414684006654	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
414684006655	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
414684006656	ABC-ATPase subunit  interface; other site
414684006657	dimer interface [polypeptide binding]; other site
414684006658	putative PBP binding regions; other site
414684006659	D-mannonate oxidoreductase; Provisional; Region: PRK08277
414684006660	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
414684006661	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
414684006662	Coenzyme A binding pocket [chemical binding]; other site
414684006663	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
414684006664	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
414684006665	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
414684006666	Predicted integral membrane protein [Function unknown]; Region: COG5637
414684006667	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
414684006668	putative hydrophobic ligand binding site [chemical binding]; other site
414684006669	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
414684006670	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
414684006671	dimerization interface [polypeptide binding]; other site
414684006672	domain crossover interface; other site
414684006673	redox-dependent activation switch; other site
414684006674	ornithine carbamoyltransferase; Provisional; Region: PRK00779
414684006675	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
414684006676	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
414684006677	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
414684006678	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
414684006679	inhibitor-cofactor binding pocket; inhibition site
414684006680	pyridoxal 5'-phosphate binding site [chemical binding]; other site
414684006681	catalytic residue [active]
414684006682	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
414684006683	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
414684006684	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
414684006685	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684006686	PAS fold; Region: PAS_3; pfam08447
414684006687	putative active site [active]
414684006688	heme pocket [chemical binding]; other site
414684006689	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
414684006690	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684006691	putative active site [active]
414684006692	heme pocket [chemical binding]; other site
414684006693	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684006694	dimer interface [polypeptide binding]; other site
414684006695	phosphorylation site [posttranslational modification]
414684006696	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684006697	ATP binding site [chemical binding]; other site
414684006698	Mg2+ binding site [ion binding]; other site
414684006699	G-X-G motif; other site
414684006700	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
414684006701	DNA polymerase I; Provisional; Region: PRK05755
414684006702	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
414684006703	active site
414684006704	metal binding site 1 [ion binding]; metal-binding site
414684006705	putative 5' ssDNA interaction site; other site
414684006706	metal binding site 3; metal-binding site
414684006707	metal binding site 2 [ion binding]; metal-binding site
414684006708	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
414684006709	putative DNA binding site [nucleotide binding]; other site
414684006710	putative metal binding site [ion binding]; other site
414684006711	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
414684006712	active site
414684006713	catalytic site [active]
414684006714	substrate binding site [chemical binding]; other site
414684006715	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
414684006716	active site
414684006717	DNA binding site [nucleotide binding]
414684006718	catalytic site [active]
414684006719	DTW domain; Region: DTW; cl01221
414684006720	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
414684006721	IHF dimer interface [polypeptide binding]; other site
414684006722	IHF - DNA interface [nucleotide binding]; other site
414684006723	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
414684006724	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
414684006725	RNA binding site [nucleotide binding]; other site
414684006726	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
414684006727	RNA binding site [nucleotide binding]; other site
414684006728	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
414684006729	RNA binding site [nucleotide binding]; other site
414684006730	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
414684006731	RNA binding site [nucleotide binding]; other site
414684006732	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
414684006733	RNA binding site [nucleotide binding]; other site
414684006734	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
414684006735	RNA binding site [nucleotide binding]; other site
414684006736	cytidylate kinase; Provisional; Region: cmk; PRK00023
414684006737	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
414684006738	CMP-binding site; other site
414684006739	The sites determining sugar specificity; other site
414684006740	PemK-like protein; Region: PemK; pfam02452
414684006741	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
414684006742	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
414684006743	putative active site [active]
414684006744	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
414684006745	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
414684006746	hinge; other site
414684006747	active site
414684006748	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
414684006749	TIGR02300 family protein; Region: FYDLN_acid
414684006750	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
414684006751	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
414684006752	active site
414684006753	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
414684006754	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
414684006755	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
414684006756	binding surface
414684006757	TPR motif; other site
414684006758	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
414684006759	Uncharacterized conserved protein [Function unknown]; Region: COG2835
414684006760	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
414684006761	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355
414684006762	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
414684006763	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
414684006764	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
414684006765	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
414684006766	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
414684006767	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
414684006768	FeS/SAM binding site; other site
414684006769	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
414684006770	Protein of unknown function, DUF599; Region: DUF599; cl01575
414684006771	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
414684006772	maleylacetoacetate isomerase; Region: maiA; TIGR01262
414684006773	C-terminal domain interface [polypeptide binding]; other site
414684006774	GSH binding site (G-site) [chemical binding]; other site
414684006775	putative dimer interface [polypeptide binding]; other site
414684006776	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
414684006777	dimer interface [polypeptide binding]; other site
414684006778	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
414684006779	N-terminal domain interface [polypeptide binding]; other site
414684006780	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
414684006781	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
414684006782	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
414684006783	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
414684006784	MarR family; Region: MarR_2; pfam12802
414684006785	Protein of unknown function (DUF433); Region: DUF433; pfam04255
414684006786	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
414684006787	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
414684006788	Walker A motif; other site
414684006789	ATP binding site [chemical binding]; other site
414684006790	Walker B motif; other site
414684006791	arginine finger; other site
414684006792	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
414684006793	phage shock protein A; Region: phageshock_pspA; TIGR02977
414684006794	Phage shock protein B; Region: PspB; pfam06667
414684006795	phage shock protein C; Region: phageshock_pspC; TIGR02978
414684006796	PspC domain; Region: PspC; pfam04024
414684006797	phage shock protein C; Region: phageshock_pspC; TIGR02978
414684006798	Phage shock protein B; Region: PspB; cl05946
414684006799	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
414684006800	putative dimer interface [polypeptide binding]; other site
414684006801	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
414684006802	acyl-CoA synthetase; Provisional; Region: PRK12582
414684006803	Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921
414684006804	acyl-activating enzyme (AAE) consensus motif; other site
414684006805	putative AMP binding site [chemical binding]; other site
414684006806	putative active site [active]
414684006807	putative CoA binding site [chemical binding]; other site
414684006808	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
414684006809	Domain of unknown function DUF21; Region: DUF21; pfam01595
414684006810	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
414684006811	Transporter associated domain; Region: CorC_HlyC; smart01091
414684006812	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
414684006813	Protein of unknown function (DUF1052); Region: DUF1052; cl02197
414684006814	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
414684006815	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
414684006816	substrate binding site [chemical binding]; other site
414684006817	ATP binding site [chemical binding]; other site
414684006818	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
414684006819	active site
414684006820	nucleotide binding site [chemical binding]; other site
414684006821	HIGH motif; other site
414684006822	KMSKS motif; other site
414684006823	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
414684006824	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
414684006825	active site
414684006826	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
414684006827	Uncharacterized conserved protein [Function unknown]; Region: COG3379
414684006828	Uncharacterized conserved protein [Function unknown]; Region: COG3379
414684006829	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
414684006830	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
414684006831	C-terminal domain interface [polypeptide binding]; other site
414684006832	GSH binding site (G-site) [chemical binding]; other site
414684006833	dimer interface [polypeptide binding]; other site
414684006834	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
414684006835	dimer interface [polypeptide binding]; other site
414684006836	N-terminal domain interface [polypeptide binding]; other site
414684006837	substrate binding pocket (H-site) [chemical binding]; other site
414684006838	Chain length determinant protein; Region: Wzz; pfam02706
414684006839	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
414684006840	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
414684006841	Magnesium ion binding site [ion binding]; other site
414684006842	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
414684006843	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
414684006844	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
414684006845	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
414684006846	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
414684006847	putative ADP-binding pocket [chemical binding]; other site
414684006848	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
414684006849	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
414684006850	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
414684006851	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
414684006852	Walker A/P-loop; other site
414684006853	ATP binding site [chemical binding]; other site
414684006854	Q-loop/lid; other site
414684006855	ABC transporter signature motif; other site
414684006856	Walker B; other site
414684006857	D-loop; other site
414684006858	H-loop/switch region; other site
414684006859	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
414684006860	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
414684006861	phosphorylation site [posttranslational modification]
414684006862	dimer interface [polypeptide binding]; other site
414684006863	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684006864	ATP binding site [chemical binding]; other site
414684006865	Mg2+ binding site [ion binding]; other site
414684006866	G-X-G motif; other site
414684006867	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
414684006868	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684006869	active site
414684006870	phosphorylation site [posttranslational modification]
414684006871	intermolecular recognition site; other site
414684006872	dimerization interface [polypeptide binding]; other site
414684006873	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
414684006874	Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022
414684006875	Bacterial sugar transferase; Region: Bac_transf; pfam02397
414684006876	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
414684006877	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
414684006878	NAD binding site [chemical binding]; other site
414684006879	homodimer interface [polypeptide binding]; other site
414684006880	active site
414684006881	substrate binding site [chemical binding]; other site
414684006882	Right handed beta helix region; Region: Beta_helix; pfam13229
414684006883	Domain of unknown function (DUF4269); Region: DUF4269; pfam14091
414684006884	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
414684006885	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
414684006886	catalytic residue [active]
414684006887	Gram-negative porin; Region: Porin_4; pfam13609
414684006888	Domain of unknown function (DUF3576); Region: DUF3576; pfam12100
414684006889	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
414684006890	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
414684006891	HIGH motif; other site
414684006892	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
414684006893	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
414684006894	active site
414684006895	KMSKS motif; other site
414684006896	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
414684006897	tRNA binding surface [nucleotide binding]; other site
414684006898	Lipopolysaccharide-assembly; Region: LptE; cl01125
414684006899	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
414684006900	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
414684006901	Protein of unknown function (DUF1440); Region: DUF1440; cl01380
414684006902	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
414684006903	nucleotide binding site [chemical binding]; other site
414684006904	putative NEF/HSP70 interaction site [polypeptide binding]; other site
414684006905	SBD interface [polypeptide binding]; other site
414684006906	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
414684006907	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
414684006908	non-specific DNA binding site [nucleotide binding]; other site
414684006909	salt bridge; other site
414684006910	sequence-specific DNA binding site [nucleotide binding]; other site
414684006911	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
414684006912	metal binding site 2 [ion binding]; metal-binding site
414684006913	putative DNA binding helix; other site
414684006914	metal binding site 1 [ion binding]; metal-binding site
414684006915	dimer interface [polypeptide binding]; other site
414684006916	structural Zn2+ binding site [ion binding]; other site
414684006917	diguanylate cyclase; Provisional; Region: PRK09894
414684006918	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
414684006919	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
414684006920	metal binding site [ion binding]; metal-binding site
414684006921	active site
414684006922	I-site; other site
414684006923	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
414684006924	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
414684006925	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
414684006926	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
414684006927	FeS/SAM binding site; other site
414684006928	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
414684006929	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
414684006930	HlyD family secretion protein; Region: HlyD_3; pfam13437
414684006931	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
414684006932	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
414684006933	dimerization interface [polypeptide binding]; other site
414684006934	putative DNA binding site [nucleotide binding]; other site
414684006935	putative Zn2+ binding site [ion binding]; other site
414684006936	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
414684006937	Protein of unknown function (DUF465); Region: DUF465; pfam04325
414684006938	Uncharacterized conserved protein [Function unknown]; Region: COG4095
414684006939	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
414684006940	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
414684006941	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
414684006942	Right handed beta helix region; Region: Beta_helix; pfam13229
414684006943	OpgC protein; Region: OpgC_C; cl17858
414684006944	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
414684006945	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
414684006946	HlyD family secretion protein; Region: HlyD_3; pfam13437
414684006947	Fusaric acid resistance protein family; Region: FUSC; pfam04632
414684006948	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
414684006949	Cupin domain; Region: Cupin_2; pfam07883
414684006950	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
414684006951	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
414684006952	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
414684006953	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
414684006954	Cation efflux family; Region: Cation_efflux; cl00316
414684006955	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
414684006956	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
414684006957	active site
414684006958	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
414684006959	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
414684006960	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
414684006961	ligand binding site [chemical binding]; other site
414684006962	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
414684006963	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684006964	active site
414684006965	phosphorylation site [posttranslational modification]
414684006966	intermolecular recognition site; other site
414684006967	dimerization interface [polypeptide binding]; other site
414684006968	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
414684006969	DNA binding residues [nucleotide binding]
414684006970	dimerization interface [polypeptide binding]; other site
414684006971	PAS fold; Region: PAS_7; pfam12860
414684006972	PAS domain S-box; Region: sensory_box; TIGR00229
414684006973	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684006974	putative active site [active]
414684006975	heme pocket [chemical binding]; other site
414684006976	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
414684006977	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684006978	putative active site [active]
414684006979	heme pocket [chemical binding]; other site
414684006980	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684006981	putative active site [active]
414684006982	heme pocket [chemical binding]; other site
414684006983	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
414684006984	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684006985	dimer interface [polypeptide binding]; other site
414684006986	phosphorylation site [posttranslational modification]
414684006987	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684006988	ATP binding site [chemical binding]; other site
414684006989	Mg2+ binding site [ion binding]; other site
414684006990	G-X-G motif; other site
414684006991	Response regulator receiver domain; Region: Response_reg; pfam00072
414684006992	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684006993	active site
414684006994	phosphorylation site [posttranslational modification]
414684006995	intermolecular recognition site; other site
414684006996	dimerization interface [polypeptide binding]; other site
414684006997	preprotein translocase subunit SecB; Validated; Region: PRK05751
414684006998	SecA binding site; other site
414684006999	Preprotein binding site; other site
414684007000	O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810
414684007001	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
414684007002	homodimer interface [polypeptide binding]; other site
414684007003	substrate-cofactor binding pocket; other site
414684007004	pyridoxal 5'-phosphate binding site [chemical binding]; other site
414684007005	catalytic residue [active]
414684007006	PII uridylyl-transferase; Provisional; Region: PRK05092
414684007007	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
414684007008	metal binding triad; other site
414684007009	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
414684007010	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
414684007011	Zn2+ binding site [ion binding]; other site
414684007012	Mg2+ binding site [ion binding]; other site
414684007013	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
414684007014	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
414684007015	Usg-like family; Region: Usg; pfam06233
414684007016	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
414684007017	oligomerisation interface [polypeptide binding]; other site
414684007018	mobile loop; other site
414684007019	roof hairpin; other site
414684007020	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
414684007021	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
414684007022	ring oligomerisation interface [polypeptide binding]; other site
414684007023	ATP/Mg binding site [chemical binding]; other site
414684007024	stacking interactions; other site
414684007025	hinge regions; other site
414684007026	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
414684007027	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
414684007028	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
414684007029	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
414684007030	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
414684007031	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
414684007032	Part of AAA domain; Region: AAA_19; pfam13245
414684007033	Family description; Region: UvrD_C_2; pfam13538
414684007034	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
414684007035	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
414684007036	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
414684007037	putative acyl-acceptor binding pocket; other site
414684007038	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
414684007039	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
414684007040	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
414684007041	CPxP  motif; other site
414684007042	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
414684007043	Coenzyme A binding pocket [chemical binding]; other site
414684007044	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
414684007045	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
414684007046	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
414684007047	putative FMN binding site [chemical binding]; other site
414684007048	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
414684007049	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
414684007050	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
414684007051	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
414684007052	cyclase homology domain; Region: CHD; cd07302
414684007053	nucleotidyl binding site; other site
414684007054	metal binding site [ion binding]; metal-binding site
414684007055	dimer interface [polypeptide binding]; other site
414684007056	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
414684007057	Ligand Binding Site [chemical binding]; other site
414684007058	Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; cl09826
414684007059	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
414684007060	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
414684007061	putative substrate binding pocket [chemical binding]; other site
414684007062	AC domain interface; other site
414684007063	catalytic triad [active]
414684007064	AB domain interface; other site
414684007065	interchain disulfide; other site
414684007066	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
414684007067	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
414684007068	active site
414684007069	HIGH motif; other site
414684007070	dimer interface [polypeptide binding]; other site
414684007071	KMSKS motif; other site
414684007072	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
414684007073	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
414684007074	putative peptidase; Provisional; Region: PRK11649
414684007075	Peptidase family M23; Region: Peptidase_M23; pfam01551
414684007076	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
414684007077	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
414684007078	Clp amino terminal domain; Region: Clp_N; pfam02861
414684007079	Clp amino terminal domain; Region: Clp_N; pfam02861
414684007080	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
414684007081	Walker A motif; other site
414684007082	ATP binding site [chemical binding]; other site
414684007083	Walker B motif; other site
414684007084	arginine finger; other site
414684007085	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
414684007086	Walker A motif; other site
414684007087	ATP binding site [chemical binding]; other site
414684007088	Walker B motif; other site
414684007089	arginine finger; other site
414684007090	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
414684007091	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
414684007092	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
414684007093	MOSC domain; Region: MOSC; pfam03473
414684007094	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
414684007095	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
414684007096	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684007097	S-adenosylmethionine binding site [chemical binding]; other site
414684007098	peptide chain release factor 1; Validated; Region: prfA; PRK00591
414684007099	This domain is found in peptide chain release factors; Region: PCRF; smart00937
414684007100	RF-1 domain; Region: RF-1; pfam00472
414684007101	Protein of unknown function (DUF497); Region: DUF497; cl01108
414684007102	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
414684007103	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
414684007104	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
414684007105	Helix-turn-helix domain; Region: HTH_25; pfam13413
414684007106	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
414684007107	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
414684007108	GAF domain; Region: GAF; pfam01590
414684007109	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
414684007110	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
414684007111	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
414684007112	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
414684007113	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
414684007114	FMN binding site [chemical binding]; other site
414684007115	substrate binding site [chemical binding]; other site
414684007116	putative catalytic residue [active]
414684007117	aspartate kinase; Reviewed; Region: PRK06635
414684007118	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
414684007119	putative nucleotide binding site [chemical binding]; other site
414684007120	putative catalytic residues [active]
414684007121	putative Mg ion binding site [ion binding]; other site
414684007122	putative aspartate binding site [chemical binding]; other site
414684007123	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
414684007124	putative allosteric regulatory site; other site
414684007125	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
414684007126	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
414684007127	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684007128	S-adenosylmethionine binding site [chemical binding]; other site
414684007129	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
414684007130	Histidine kinase; Region: HisKA_2; pfam07568
414684007131	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684007132	ATP binding site [chemical binding]; other site
414684007133	Mg2+ binding site [ion binding]; other site
414684007134	G-X-G motif; other site
414684007135	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
414684007136	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
414684007137	NAD binding site [chemical binding]; other site
414684007138	catalytic Zn binding site [ion binding]; other site
414684007139	structural Zn binding site [ion binding]; other site
414684007140	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
414684007141	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
414684007142	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
414684007143	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
414684007144	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
414684007145	metal binding triad; other site
414684007146	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
414684007147	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
414684007148	Na binding site [ion binding]; other site
414684007149	Protein of unknown function, DUF485; Region: DUF485; pfam04341
414684007150	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
414684007151	PAS domain S-box; Region: sensory_box; TIGR00229
414684007152	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684007153	putative active site [active]
414684007154	heme pocket [chemical binding]; other site
414684007155	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684007156	dimer interface [polypeptide binding]; other site
414684007157	phosphorylation site [posttranslational modification]
414684007158	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684007159	ATP binding site [chemical binding]; other site
414684007160	Mg2+ binding site [ion binding]; other site
414684007161	G-X-G motif; other site
414684007162	Response regulator receiver domain; Region: Response_reg; pfam00072
414684007163	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684007164	active site
414684007165	phosphorylation site [posttranslational modification]
414684007166	intermolecular recognition site; other site
414684007167	dimerization interface [polypeptide binding]; other site
414684007168	nitrilase; Region: PLN02798
414684007169	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
414684007170	putative active site [active]
414684007171	catalytic triad [active]
414684007172	dimer interface [polypeptide binding]; other site
414684007173	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
414684007174	GSH binding site [chemical binding]; other site
414684007175	catalytic residues [active]
414684007176	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
414684007177	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
414684007178	active site
414684007179	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
414684007180	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684007181	S-adenosylmethionine binding site [chemical binding]; other site
414684007182	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
414684007183	active site
414684007184	8-oxo-dGMP binding site [chemical binding]; other site
414684007185	nudix motif; other site
414684007186	metal binding site [ion binding]; metal-binding site
414684007187	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
414684007188	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
414684007189	Coenzyme A binding pocket [chemical binding]; other site
414684007190	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
414684007191	heterotetramer interface [polypeptide binding]; other site
414684007192	active site pocket [active]
414684007193	cleavage site
414684007194	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
414684007195	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
414684007196	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
414684007197	SEC-C motif; Region: SEC-C; pfam02810
414684007198	Protein of unknown function DUF86; Region: DUF86; cl01031
414684007199	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
414684007200	active site
414684007201	NTP binding site [chemical binding]; other site
414684007202	metal binding triad [ion binding]; metal-binding site
414684007203	antibiotic binding site [chemical binding]; other site
414684007204	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
414684007205	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
414684007206	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
414684007207	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
414684007208	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
414684007209	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
414684007210	Domain of unknown function DUF21; Region: DUF21; pfam01595
414684007211	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
414684007212	Transporter associated domain; Region: CorC_HlyC; smart01091
414684007213	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
414684007214	active site
414684007215	dimer interface [polypeptide binding]; other site
414684007216	metal binding site [ion binding]; metal-binding site
414684007217	shikimate kinase; Reviewed; Region: aroK; PRK00131
414684007218	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
414684007219	ADP binding site [chemical binding]; other site
414684007220	magnesium binding site [ion binding]; other site
414684007221	putative shikimate binding site; other site
414684007222	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
414684007223	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
414684007224	active site
414684007225	DNA binding site [nucleotide binding]
414684007226	Int/Topo IB signature motif; other site
414684007227	Restriction endonuclease BglII; Region: Endonuc-BglII; pfam09195
414684007228	MT-A70; Region: MT-A70; cl01947
414684007229	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
414684007230	Thymidylate kinase; Region: Thymidylate_kin; pfam02223
414684007231	TMP-binding site; other site
414684007232	ATP-binding site [chemical binding]; other site
414684007233	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
414684007234	putative active site [active]
414684007235	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
414684007236	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
414684007237	non-specific DNA binding site [nucleotide binding]; other site
414684007238	salt bridge; other site
414684007239	sequence-specific DNA binding site [nucleotide binding]; other site
414684007240	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
414684007241	Domain of unknown function (DUF955); Region: DUF955; pfam06114
414684007242	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
414684007243	isocitrate lyase; Provisional; Region: PRK15063
414684007244	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
414684007245	tetramer interface [polypeptide binding]; other site
414684007246	active site
414684007247	Mg2+/Mn2+ binding site [ion binding]; other site
414684007248	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
414684007249	malate synthase A; Region: malate_syn_A; TIGR01344
414684007250	active site
414684007251	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
414684007252	dimanganese center [ion binding]; other site
414684007253	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
414684007254	active site
414684007255	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
414684007256	enoyl-CoA hydratase; Provisional; Region: PRK06210
414684007257	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
414684007258	substrate binding site [chemical binding]; other site
414684007259	oxyanion hole (OAH) forming residues; other site
414684007260	trimer interface [polypeptide binding]; other site
414684007261	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
414684007262	flagellar motor protein MotA; Validated; Region: PRK09110
414684007263	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
414684007264	long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12406
414684007265	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
414684007266	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
414684007267	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
414684007268	acyl-activating enzyme (AAE) consensus motif; other site
414684007269	acyl-activating enzyme (AAE) consensus motif; other site
414684007270	putative AMP binding site [chemical binding]; other site
414684007271	putative active site [active]
414684007272	putative CoA binding site [chemical binding]; other site
414684007273	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
414684007274	dimerization interface [polypeptide binding]; other site
414684007275	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
414684007276	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684007277	dimer interface [polypeptide binding]; other site
414684007278	putative CheW interface [polypeptide binding]; other site
414684007279	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
414684007280	Active_site [active]
414684007281	Transglycosylase; Region: Transgly; pfam00912
414684007282	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
414684007283	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
414684007284	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
414684007285	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
414684007286	FMN binding site [chemical binding]; other site
414684007287	active site
414684007288	substrate binding site [chemical binding]; other site
414684007289	catalytic residue [active]
414684007290	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
414684007291	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
414684007292	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
414684007293	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
414684007294	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
414684007295	trimer interface; other site
414684007296	sugar binding site [chemical binding]; other site
414684007297	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
414684007298	Na binding site [ion binding]; other site
414684007299	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
414684007300	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
414684007301	substrate binding pocket [chemical binding]; other site
414684007302	membrane-bound complex binding site; other site
414684007303	hinge residues; other site
414684007304	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
414684007305	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
414684007306	substrate binding pocket [chemical binding]; other site
414684007307	membrane-bound complex binding site; other site
414684007308	hinge residues; other site
414684007309	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
414684007310	ABC-ATPase subunit interface; other site
414684007311	putative PBP binding loops; other site
414684007312	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
414684007313	dimer interface [polypeptide binding]; other site
414684007314	conserved gate region; other site
414684007315	putative PBP binding loops; other site
414684007316	ABC-ATPase subunit interface; other site
414684007317	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
414684007318	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
414684007319	homotetramer interface [polypeptide binding]; other site
414684007320	ligand binding site [chemical binding]; other site
414684007321	catalytic site [active]
414684007322	NAD binding site [chemical binding]; other site
414684007323	PAS fold; Region: PAS; pfam00989
414684007324	PAS fold; Region: PAS_7; pfam12860
414684007325	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
414684007326	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684007327	dimer interface [polypeptide binding]; other site
414684007328	phosphorylation site [posttranslational modification]
414684007329	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684007330	ATP binding site [chemical binding]; other site
414684007331	Mg2+ binding site [ion binding]; other site
414684007332	G-X-G motif; other site
414684007333	Domain of unknown function (DUF2383); Region: DUF2383; cl17556
414684007334	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
414684007335	PAS domain S-box; Region: sensory_box; TIGR00229
414684007336	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684007337	putative active site [active]
414684007338	heme pocket [chemical binding]; other site
414684007339	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
414684007340	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684007341	dimer interface [polypeptide binding]; other site
414684007342	phosphorylation site [posttranslational modification]
414684007343	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684007344	ATP binding site [chemical binding]; other site
414684007345	Mg2+ binding site [ion binding]; other site
414684007346	G-X-G motif; other site
414684007347	HemK family putative methylases; Region: hemK_fam; TIGR00536
414684007348	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684007349	S-adenosylmethionine binding site [chemical binding]; other site
414684007350	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
414684007351	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
414684007352	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
414684007353	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419
414684007354	putative active site [active]
414684007355	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
414684007356	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
414684007357	Walker A/P-loop; other site
414684007358	ATP binding site [chemical binding]; other site
414684007359	Q-loop/lid; other site
414684007360	ABC transporter signature motif; other site
414684007361	Walker B; other site
414684007362	D-loop; other site
414684007363	H-loop/switch region; other site
414684007364	DDE superfamily endonuclease; Region: DDE_3; pfam13358
414684007365	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
414684007366	Winged helix-turn helix; Region: HTH_29; pfam13551
414684007367	Helix-turn-helix domain; Region: HTH_28; pfam13518
414684007368	Winged helix-turn helix; Region: HTH_33; pfam13592
414684007369	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
414684007370	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
414684007371	HlyD family secretion protein; Region: HlyD_3; pfam13437
414684007372	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
414684007373	active site
414684007374	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
414684007375	putative active site pocket [active]
414684007376	cleavage site
414684007377	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
414684007378	cleavage site
414684007379	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
414684007380	L-asparaginase II; Region: Asparaginase_II; pfam06089
414684007381	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
414684007382	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
414684007383	NAD(P) binding site [chemical binding]; other site
414684007384	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
414684007385	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
414684007386	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
414684007387	ligand binding site; other site
414684007388	oligomer interface; other site
414684007389	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
414684007390	dimer interface [polypeptide binding]; other site
414684007391	N-terminal domain interface [polypeptide binding]; other site
414684007392	sulfate 1 binding site; other site
414684007393	glycogen synthase; Provisional; Region: glgA; PRK00654
414684007394	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
414684007395	ADP-binding pocket [chemical binding]; other site
414684007396	homodimer interface [polypeptide binding]; other site
414684007397	PAS domain S-box; Region: sensory_box; TIGR00229
414684007398	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684007399	dimer interface [polypeptide binding]; other site
414684007400	phosphorylation site [posttranslational modification]
414684007401	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684007402	ATP binding site [chemical binding]; other site
414684007403	G-X-G motif; other site
414684007404	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
414684007405	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684007406	active site
414684007407	phosphorylation site [posttranslational modification]
414684007408	intermolecular recognition site; other site
414684007409	dimerization interface [polypeptide binding]; other site
414684007410	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
414684007411	active site
414684007412	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
414684007413	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
414684007414	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
414684007415	Predicted methyltransferase [General function prediction only]; Region: COG4798
414684007416	Methyltransferase domain; Region: Methyltransf_23; pfam13489
414684007417	PIN domain; Region: PIN_3; pfam13470
414684007418	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
414684007419	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
414684007420	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
414684007421	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
414684007422	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
414684007423	putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567
414684007424	FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192
414684007425	FAD binding pocket [chemical binding]; other site
414684007426	FAD binding motif [chemical binding]; other site
414684007427	phosphate binding motif [ion binding]; other site
414684007428	beta-alpha-beta structure motif; other site
414684007429	NAD binding pocket [chemical binding]; other site
414684007430	Iron coordination center [ion binding]; other site
414684007431	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
414684007432	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
414684007433	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
414684007434	motif II; other site
414684007435	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
414684007436	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
414684007437	CoA binding domain; Region: CoA_binding_2; pfam13380
414684007438	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
414684007439	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
414684007440	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
414684007441	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
414684007442	Predicted membrane protein [Function unknown]; Region: COG3671
414684007443	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
414684007444	dimer interface [polypeptide binding]; other site
414684007445	substrate binding site [chemical binding]; other site
414684007446	metal binding sites [ion binding]; metal-binding site
414684007447	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
414684007448	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
414684007449	substrate binding site [chemical binding]; other site
414684007450	ATP binding site [chemical binding]; other site
414684007451	Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126
414684007452	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
414684007453	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
414684007454	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
414684007455	minor groove reading motif; other site
414684007456	helix-hairpin-helix signature motif; other site
414684007457	substrate binding pocket [chemical binding]; other site
414684007458	active site
414684007459	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
414684007460	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
414684007461	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
414684007462	active site
414684007463	kynureninase; Region: kynureninase; TIGR01814
414684007464	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
414684007465	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
414684007466	catalytic residue [active]
414684007467	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
414684007468	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
414684007469	peptide binding site [polypeptide binding]; other site
414684007470	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
414684007471	Putative cyclase; Region: Cyclase; cl00814
414684007472	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
414684007473	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
414684007474	putative DNA binding site [nucleotide binding]; other site
414684007475	putative Zn2+ binding site [ion binding]; other site
414684007476	AsnC family; Region: AsnC_trans_reg; pfam01037
414684007477	tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036
414684007478	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
414684007479	active site
414684007480	zinc binding site [ion binding]; other site
414684007481	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
414684007482	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
414684007483	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
414684007484	Nitrogen regulatory protein P-II; Region: P-II; smart00938
414684007485	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
414684007486	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
414684007487	pyridoxal 5'-phosphate binding site [chemical binding]; other site
414684007488	homodimer interface [polypeptide binding]; other site
414684007489	catalytic residue [active]
414684007490	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
414684007491	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
414684007492	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
414684007493	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
414684007494	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
414684007495	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
414684007496	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
414684007497	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
414684007498	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
414684007499	Peptidase C26; Region: Peptidase_C26; pfam07722
414684007500	catalytic triad [active]
414684007501	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
414684007502	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
414684007503	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
414684007504	non-specific DNA binding site [nucleotide binding]; other site
414684007505	salt bridge; other site
414684007506	sequence-specific DNA binding site [nucleotide binding]; other site
414684007507	ferredoxin reductase fragment pseudogene
414684007508	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
414684007509	putative catalytic site [active]
414684007510	putative phosphate binding site [ion binding]; other site
414684007511	active site
414684007512	metal binding site A [ion binding]; metal-binding site
414684007513	DNA binding site [nucleotide binding]
414684007514	putative AP binding site [nucleotide binding]; other site
414684007515	putative metal binding site B [ion binding]; other site
414684007516	transcription termination factor Rho; Provisional; Region: rho; PRK09376
414684007517	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
414684007518	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
414684007519	RNA binding site [nucleotide binding]; other site
414684007520	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
414684007521	multimer interface [polypeptide binding]; other site
414684007522	Walker A motif; other site
414684007523	ATP binding site [chemical binding]; other site
414684007524	Walker B motif; other site
414684007525	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
414684007526	ligand binding site [chemical binding]; other site
414684007527	dimer interface [polypeptide binding]; other site
414684007528	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
414684007529	ferrochelatase; Reviewed; Region: hemH; PRK00035
414684007530	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
414684007531	C-terminal domain interface [polypeptide binding]; other site
414684007532	active site
414684007533	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
414684007534	active site
414684007535	N-terminal domain interface [polypeptide binding]; other site
414684007536	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
414684007537	substrate binding site [chemical binding]; other site
414684007538	active site
414684007539	PEP synthetase regulatory protein; Provisional; Region: PRK05339
414684007540	Maf-like protein; Provisional; Region: PRK14361
414684007541	Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276
414684007542	putative active site [active]
414684007543	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
414684007544	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
414684007545	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
414684007546	NAD(P) binding site [chemical binding]; other site
414684007547	shikimate binding site; other site
414684007548	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
414684007549	dephospho-CoA kinase; Region: TIGR00152
414684007550	CoA-binding site [chemical binding]; other site
414684007551	ATP-binding [chemical binding]; other site
414684007552	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
414684007553	active site
414684007554	catalytic site [active]
414684007555	substrate binding site [chemical binding]; other site
414684007556	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
414684007557	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
414684007558	NADP binding site [chemical binding]; other site
414684007559	dimer interface [polypeptide binding]; other site
414684007560	Dienelactone hydrolase family; Region: DLH; pfam01738
414684007561	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
414684007562	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
414684007563	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
414684007564	catalytic residues [active]
414684007565	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
414684007566	dimer interface [polypeptide binding]; other site
414684007567	[2Fe-2S] cluster binding site [ion binding]; other site
414684007568	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
414684007569	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
414684007570	trmE is a tRNA modification GTPase; Region: trmE; cd04164
414684007571	G1 box; other site
414684007572	GTP/Mg2+ binding site [chemical binding]; other site
414684007573	Switch I region; other site
414684007574	G2 box; other site
414684007575	Switch II region; other site
414684007576	G3 box; other site
414684007577	G4 box; other site
414684007578	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
414684007579	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
414684007580	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
414684007581	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
414684007582	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
414684007583	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
414684007584	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
414684007585	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
414684007586	P-loop; other site
414684007587	Magnesium ion binding site [ion binding]; other site
414684007588	ParB-like nuclease domain; Region: ParB; smart00470
414684007589	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
414684007590	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
414684007591	Methyltransferase domain; Region: Methyltransf_23; pfam13489
414684007592	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
414684007593	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
414684007594	catalytic site [active]
414684007595	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
414684007596	This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819
414684007597	putative ADP-binding pocket [chemical binding]; other site
414684007598	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
414684007599	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
414684007600	putative active site [active]
414684007601	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
414684007602	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
414684007603	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
414684007604	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
414684007605	active site
414684007606	dimer interface [polypeptide binding]; other site
414684007607	motif 1; other site
414684007608	motif 2; other site
414684007609	motif 3; other site
414684007610	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
414684007611	anticodon binding site; other site
414684007612	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
414684007613	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
414684007614	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
414684007615	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
414684007616	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
414684007617	active site
414684007618	substrate-binding site [chemical binding]; other site
414684007619	metal-binding site [ion binding]
414684007620	ATP binding site [chemical binding]; other site
414684007621	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
414684007622	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
414684007623	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
414684007624	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
414684007625	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684007626	active site
414684007627	phosphorylation site [posttranslational modification]
414684007628	intermolecular recognition site; other site
414684007629	dimerization interface [polypeptide binding]; other site
414684007630	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
414684007631	DNA binding site [nucleotide binding]
414684007632	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
414684007633	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
414684007634	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
414684007635	dimerization interface [polypeptide binding]; other site
414684007636	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684007637	dimer interface [polypeptide binding]; other site
414684007638	phosphorylation site [posttranslational modification]
414684007639	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684007640	ATP binding site [chemical binding]; other site
414684007641	Mg2+ binding site [ion binding]; other site
414684007642	G-X-G motif; other site
414684007643	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
414684007644	PAS domain; Region: PAS_9; pfam13426
414684007645	putative active site [active]
414684007646	heme pocket [chemical binding]; other site
414684007647	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684007648	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
414684007649	putative active site [active]
414684007650	heme pocket [chemical binding]; other site
414684007651	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684007652	putative active site [active]
414684007653	heme pocket [chemical binding]; other site
414684007654	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684007655	PAS fold; Region: PAS_3; pfam08447
414684007656	putative active site [active]
414684007657	heme pocket [chemical binding]; other site
414684007658	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
414684007659	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684007660	dimer interface [polypeptide binding]; other site
414684007661	phosphorylation site [posttranslational modification]
414684007662	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684007663	ATP binding site [chemical binding]; other site
414684007664	Mg2+ binding site [ion binding]; other site
414684007665	G-X-G motif; other site
414684007666	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
414684007667	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
414684007668	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
414684007669	pyridoxal 5'-phosphate binding site [chemical binding]; other site
414684007670	catalytic residue [active]
414684007671	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
414684007672	substrate binding site [chemical binding]; other site
414684007673	active site
414684007674	catalytic residues [active]
414684007675	heterodimer interface [polypeptide binding]; other site
414684007676	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
414684007677	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
414684007678	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
414684007679	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
414684007680	MAPEG family; Region: MAPEG; cl09190
414684007681	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
414684007682	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
414684007683	catalytic residues [active]
414684007684	Ion transport protein; Region: Ion_trans; pfam00520
414684007685	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
414684007686	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
414684007687	enoyl-CoA hydratase; Region: PLN02864
414684007688	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
414684007689	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
414684007690	dimer interaction site [polypeptide binding]; other site
414684007691	substrate-binding tunnel; other site
414684007692	active site
414684007693	catalytic site [active]
414684007694	substrate binding site [chemical binding]; other site
414684007695	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
414684007696	Major Facilitator Superfamily; Region: MFS_1; pfam07690
414684007697	putative substrate translocation pore; other site
414684007698	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
414684007699	Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119
414684007700	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
414684007701	GAF domain; Region: GAF; pfam01590
414684007702	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684007703	PAS fold; Region: PAS_3; pfam08447
414684007704	putative active site [active]
414684007705	heme pocket [chemical binding]; other site
414684007706	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
414684007707	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684007708	dimer interface [polypeptide binding]; other site
414684007709	phosphorylation site [posttranslational modification]
414684007710	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684007711	ATP binding site [chemical binding]; other site
414684007712	Mg2+ binding site [ion binding]; other site
414684007713	G-X-G motif; other site
414684007714	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
414684007715	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684007716	active site
414684007717	phosphorylation site [posttranslational modification]
414684007718	intermolecular recognition site; other site
414684007719	dimerization interface [polypeptide binding]; other site
414684007720	RecX family; Region: RecX; cl00936
414684007721	ABC-2 type transporter; Region: ABC2_membrane; cl17235
414684007722	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
414684007723	ABC-2 type transporter; Region: ABC2_membrane; cl17235
414684007724	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
414684007725	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
414684007726	5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase pseudogene;(Methionine synt Hase, vitamin-B12 independent isozyme) (Cobalamin-independent methionine synt Hase)
414684007727	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
414684007728	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
414684007729	nucleotide binding site [chemical binding]; other site
414684007730	NEF interaction site [polypeptide binding]; other site
414684007731	SBD interface [polypeptide binding]; other site
414684007732	chaperone protein DnaJ; Provisional; Region: PRK10767
414684007733	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
414684007734	HSP70 interaction site [polypeptide binding]; other site
414684007735	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
414684007736	substrate binding site [polypeptide binding]; other site
414684007737	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
414684007738	Zn binding sites [ion binding]; other site
414684007739	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
414684007740	dimer interface [polypeptide binding]; other site
414684007741	Protein of unknown function (DUF952); Region: DUF952; pfam06108
414684007742	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
414684007743	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
414684007744	quinone interaction residues [chemical binding]; other site
414684007745	active site
414684007746	catalytic residues [active]
414684007747	FMN binding site [chemical binding]; other site
414684007748	substrate binding site [chemical binding]; other site
414684007749	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
414684007750	conserved cys residue [active]
414684007751	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
414684007752	putative catalytic site [active]
414684007753	putative metal binding site [ion binding]; other site
414684007754	putative phosphate binding site [ion binding]; other site
414684007755	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
414684007756	active site
414684007757	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
414684007758	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
414684007759	active pocket/dimerization site; other site
414684007760	active site
414684007761	phosphorylation site [posttranslational modification]
414684007762	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
414684007763	regulatory protein interface [polypeptide binding]; other site
414684007764	active site
414684007765	regulatory phosphorylation site [posttranslational modification]; other site
414684007766	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
414684007767	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
414684007768	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
414684007769	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
414684007770	YGGT family; Region: YGGT; pfam02325
414684007771	Uncharacterized conserved protein [Function unknown]; Region: COG1872
414684007772	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
414684007773	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
414684007774	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
414684007775	homodimer interface [polypeptide binding]; other site
414684007776	NADP binding site [chemical binding]; other site
414684007777	substrate binding site [chemical binding]; other site
414684007778	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
414684007779	uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837
414684007780	Cl binding site [ion binding]; other site
414684007781	oligomer interface [polypeptide binding]; other site
414684007782	glutathione synthetase; Provisional; Region: PRK05246
414684007783	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
414684007784	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
414684007785	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
414684007786	Cysteine-rich domain; Region: CCG; pfam02754
414684007787	Cysteine-rich domain; Region: CCG; pfam02754
414684007788	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
414684007789	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
414684007790	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
414684007791	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
414684007792	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
414684007793	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
414684007794	Smr domain; Region: Smr; pfam01713
414684007795	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
414684007796	NnrU protein; Region: NnrU; pfam07298
414684007797	putative cation:proton antiport protein; Provisional; Region: PRK10669
414684007798	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
414684007799	TrkA-N domain; Region: TrkA_N; pfam02254
414684007800	argininosuccinate synthase; Provisional; Region: PRK13820
414684007801	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
414684007802	ANP binding site [chemical binding]; other site
414684007803	Substrate Binding Site II [chemical binding]; other site
414684007804	Substrate Binding Site I [chemical binding]; other site
414684007805	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
414684007806	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
414684007807	putative active site [active]
414684007808	catalytic site [active]
414684007809	putative metal binding site [ion binding]; other site
414684007810	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
414684007811	intracellular protease, PfpI family; Region: PfpI; TIGR01382
414684007812	proposed catalytic triad [active]
414684007813	conserved cys residue [active]
414684007814	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
414684007815	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684007816	PAS fold; Region: PAS_3; pfam08447
414684007817	putative active site [active]
414684007818	heme pocket [chemical binding]; other site
414684007819	PAS domain S-box; Region: sensory_box; TIGR00229
414684007820	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684007821	putative active site [active]
414684007822	heme pocket [chemical binding]; other site
414684007823	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
414684007824	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684007825	dimer interface [polypeptide binding]; other site
414684007826	phosphorylation site [posttranslational modification]
414684007827	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684007828	ATP binding site [chemical binding]; other site
414684007829	Mg2+ binding site [ion binding]; other site
414684007830	G-X-G motif; other site
414684007831	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
414684007832	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
414684007833	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
414684007834	Walker A/P-loop; other site
414684007835	ATP binding site [chemical binding]; other site
414684007836	Q-loop/lid; other site
414684007837	ABC transporter signature motif; other site
414684007838	Walker B; other site
414684007839	D-loop; other site
414684007840	H-loop/switch region; other site
414684007841	MAPEG family; Region: MAPEG; pfam01124
414684007842	NAD-dependent deacetylase; Provisional; Region: PRK00481
414684007843	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
414684007844	NAD+ binding site [chemical binding]; other site
414684007845	substrate binding site [chemical binding]; other site
414684007846	Zn binding site [ion binding]; other site
414684007847	Low molecular weight phosphatase family; Region: LMWPc; cd00115
414684007848	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
414684007849	active site
414684007850	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
414684007851	PAS domain; Region: PAS_5; pfam07310
414684007852	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
414684007853	MutS domain I; Region: MutS_I; pfam01624
414684007854	MutS domain II; Region: MutS_II; pfam05188
414684007855	MutS domain III; Region: MutS_III; pfam05192
414684007856	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
414684007857	Walker A/P-loop; other site
414684007858	ATP binding site [chemical binding]; other site
414684007859	Q-loop/lid; other site
414684007860	ABC transporter signature motif; other site
414684007861	Walker B; other site
414684007862	D-loop; other site
414684007863	H-loop/switch region; other site
414684007864	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
414684007865	putative active site [active]
414684007866	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
414684007867	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
414684007868	Walker A/P-loop; other site
414684007869	ATP binding site [chemical binding]; other site
414684007870	Q-loop/lid; other site
414684007871	ABC transporter signature motif; other site
414684007872	Walker B; other site
414684007873	D-loop; other site
414684007874	H-loop/switch region; other site
414684007875	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
414684007876	FtsX-like permease family; Region: FtsX; pfam02687
414684007877	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
414684007878	ribosome maturation protein RimP; Reviewed; Region: PRK00092
414684007879	Sm and related proteins; Region: Sm_like; cl00259
414684007880	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
414684007881	putative RNA binding site [nucleotide binding]; other site
414684007882	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
414684007883	NusA N-terminal domain; Region: NusA_N; pfam08529
414684007884	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
414684007885	RNA binding site [nucleotide binding]; other site
414684007886	homodimer interface [polypeptide binding]; other site
414684007887	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
414684007888	G-X-X-G motif; other site
414684007889	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
414684007890	G-X-X-G motif; other site
414684007891	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
414684007892	hypothetical protein; Provisional; Region: PRK09190
414684007893	Protein of unknown function (DUF448); Region: DUF448; pfam04296
414684007894	putative RNA binding cleft [nucleotide binding]; other site
414684007895	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
414684007896	translation initiation factor IF-2; Region: IF-2; TIGR00487
414684007897	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
414684007898	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
414684007899	G1 box; other site
414684007900	putative GEF interaction site [polypeptide binding]; other site
414684007901	GTP/Mg2+ binding site [chemical binding]; other site
414684007902	Switch I region; other site
414684007903	G2 box; other site
414684007904	G3 box; other site
414684007905	Switch II region; other site
414684007906	G4 box; other site
414684007907	G5 box; other site
414684007908	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
414684007909	Translation-initiation factor 2; Region: IF-2; pfam11987
414684007910	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
414684007911	Helix-turn-helix domain; Region: HTH_18; pfam12833
414684007912	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
414684007913	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_15; cd07264
414684007914	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
414684007915	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
414684007916	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
414684007917	RNA binding site [nucleotide binding]; other site
414684007918	active site
414684007919	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
414684007920	16S/18S rRNA binding site [nucleotide binding]; other site
414684007921	S13e-L30e interaction site [polypeptide binding]; other site
414684007922	25S rRNA binding site [nucleotide binding]; other site
414684007923	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
414684007924	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
414684007925	RNase E interface [polypeptide binding]; other site
414684007926	trimer interface [polypeptide binding]; other site
414684007927	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
414684007928	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
414684007929	RNase E interface [polypeptide binding]; other site
414684007930	trimer interface [polypeptide binding]; other site
414684007931	active site
414684007932	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
414684007933	putative nucleic acid binding region [nucleotide binding]; other site
414684007934	G-X-X-G motif; other site
414684007935	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
414684007936	RNA binding site [nucleotide binding]; other site
414684007937	domain interface; other site
414684007938	Transposase domain (DUF772); Region: DUF772; pfam05598
414684007939	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
414684007940	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
414684007941	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
414684007942	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
414684007943	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
414684007944	Peptidase M15; Region: Peptidase_M15_3; cl01194
414684007945	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
414684007946	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
414684007947	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
414684007948	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
414684007949	phosphorylation site [posttranslational modification]
414684007950	intermolecular recognition site; other site
414684007951	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
414684007952	DNA binding site [nucleotide binding]
414684007953	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
414684007954	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
414684007955	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
414684007956	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
414684007957	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
414684007958	putative NAD(P) binding site [chemical binding]; other site
414684007959	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
414684007960	dimerization interface [polypeptide binding]; other site
414684007961	active site
414684007962	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
414684007963	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
414684007964	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
414684007965	putative active site [active]
414684007966	catalytic site [active]
414684007967	putative metal binding site [ion binding]; other site
414684007968	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
414684007969	FMN binding site [chemical binding]; other site
414684007970	substrate binding site [chemical binding]; other site
414684007971	putative catalytic residue [active]
414684007972	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
414684007973	metal binding site 2 [ion binding]; metal-binding site
414684007974	putative DNA binding helix; other site
414684007975	metal binding site 1 [ion binding]; metal-binding site
414684007976	dimer interface [polypeptide binding]; other site
414684007977	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
414684007978	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
414684007979	short chain dehydrogenase; Provisional; Region: PRK06523
414684007980	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
414684007981	NAD(P) binding site [chemical binding]; other site
414684007982	active site
414684007983	SnoaL-like domain; Region: SnoaL_2; pfam12680
414684007984	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
414684007985	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
414684007986	Transcriptional regulator [Transcription]; Region: LysR; COG0583
414684007987	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
414684007988	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
414684007989	putative effector binding pocket; other site
414684007990	putative dimerization interface [polypeptide binding]; other site
414684007991	putative transporter; Provisional; Region: PRK11043
414684007992	multidrug efflux system protein; Provisional; Region: PRK11431
414684007993	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
414684007994	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
414684007995	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
414684007996	Walker A motif; other site
414684007997	ATP binding site [chemical binding]; other site
414684007998	Walker B motif; other site
414684007999	arginine finger; other site
414684008000	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
414684008001	GrpE; Region: GrpE; pfam01025
414684008002	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
414684008003	dimer interface [polypeptide binding]; other site
414684008004	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
414684008005	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
414684008006	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
414684008007	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
414684008008	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
414684008009	non-specific DNA binding site [nucleotide binding]; other site
414684008010	salt bridge; other site
414684008011	sequence-specific DNA binding site [nucleotide binding]; other site
414684008012	ribonuclease PH; Reviewed; Region: rph; PRK00173
414684008013	Ribonuclease PH; Region: RNase_PH_bact; cd11362
414684008014	hexamer interface [polypeptide binding]; other site
414684008015	active site
414684008016	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
414684008017	active site
414684008018	dimerization interface [polypeptide binding]; other site
414684008019	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859
414684008020	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
414684008021	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
414684008022	FeS/SAM binding site; other site
414684008023	HemN C-terminal domain; Region: HemN_C; pfam06969
414684008024	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
414684008025	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
414684008026	acyl-activating enzyme (AAE) consensus motif; other site
414684008027	putative AMP binding site [chemical binding]; other site
414684008028	putative active site [active]
414684008029	putative CoA binding site [chemical binding]; other site
414684008030	patatin-related protein; Region: TIGR03607
414684008031	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
414684008032	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
414684008033	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
414684008034	DNA binding site [nucleotide binding]
414684008035	active site
414684008036	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
414684008037	dinuclear metal binding motif [ion binding]; other site
414684008038	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
414684008039	S-adenosylmethionine synthetase; Validated; Region: PRK05250
414684008040	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
414684008041	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
414684008042	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
414684008043	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
414684008044	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
414684008045	non-specific DNA binding site [nucleotide binding]; other site
414684008046	salt bridge; other site
414684008047	sequence-specific DNA binding site [nucleotide binding]; other site
414684008048	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
414684008049	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
414684008050	putative active site [active]
414684008051	catalytic triad [active]
414684008052	putative dimer interface [polypeptide binding]; other site
414684008053	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
414684008054	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
414684008055	Transporter associated domain; Region: CorC_HlyC; smart01091
414684008056	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
414684008057	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
414684008058	PhoH-like protein; Region: PhoH; pfam02562
414684008059	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
414684008060	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
414684008061	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
414684008062	FeS/SAM binding site; other site
414684008063	TRAM domain; Region: TRAM; pfam01938
414684008064	RNA polymerase sigma factor; Provisional; Region: PRK12526
414684008065	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
414684008066	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
414684008067	DNA binding residues [nucleotide binding]
414684008068	anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451
414684008069	Putative zinc-finger; Region: zf-HC2; pfam13490
414684008070	Cupin domain; Region: Cupin_2; pfam07883
414684008071	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
414684008072	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
414684008073	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
414684008074	ligand binding site [chemical binding]; other site
414684008075	flexible hinge region; other site
414684008076	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
414684008077	putative switch regulator; other site
414684008078	non-specific DNA interactions [nucleotide binding]; other site
414684008079	DNA binding site [nucleotide binding]
414684008080	sequence specific DNA binding site [nucleotide binding]; other site
414684008081	putative cAMP binding site [chemical binding]; other site
414684008082	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
414684008083	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
414684008084	putative RNA binding site [nucleotide binding]; other site
414684008085	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684008086	S-adenosylmethionine binding site [chemical binding]; other site
414684008087	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
414684008088	Coenzyme A binding pocket [chemical binding]; other site
414684008089	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
414684008090	quinolinate synthetase; Provisional; Region: PRK09375
414684008091	L-aspartate oxidase; Provisional; Region: PRK06175
414684008092	FAD binding domain; Region: FAD_binding_2; pfam00890
414684008093	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
414684008094	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106
414684008095	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
414684008096	dimerization interface [polypeptide binding]; other site
414684008097	active site
414684008098	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
414684008099	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
414684008100	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
414684008101	Low molecular weight phosphatase family; Region: LMWPc; cl00105
414684008102	active site
414684008103	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
414684008104	Sodium Bile acid symporter family; Region: SBF; cl17470
414684008105	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
414684008106	aromatic arch; other site
414684008107	DCoH dimer interaction site [polypeptide binding]; other site
414684008108	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
414684008109	DCoH tetramer interaction site [polypeptide binding]; other site
414684008110	substrate binding site [chemical binding]; other site
414684008111	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
414684008112	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
414684008113	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
414684008114	Walker A/P-loop; other site
414684008115	ATP binding site [chemical binding]; other site
414684008116	Q-loop/lid; other site
414684008117	ABC transporter signature motif; other site
414684008118	Walker B; other site
414684008119	D-loop; other site
414684008120	H-loop/switch region; other site
414684008121	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
414684008122	Tim44-like domain; Region: Tim44; pfam04280
414684008123	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
414684008124	MltA specific insert domain; Region: MltA; smart00925
414684008125	3D domain; Region: 3D; pfam06725
414684008126	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
414684008127	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
414684008128	N-terminal plug; other site
414684008129	ligand-binding site [chemical binding]; other site
414684008130	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
414684008131	dimerization interface [polypeptide binding]; other site
414684008132	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
414684008133	GAF domain; Region: GAF; pfam01590
414684008134	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684008135	dimer interface [polypeptide binding]; other site
414684008136	phosphorylation site [posttranslational modification]
414684008137	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684008138	ATP binding site [chemical binding]; other site
414684008139	Mg2+ binding site [ion binding]; other site
414684008140	G-X-G motif; other site
414684008141	aspartate aminotransferase; Provisional; Region: PRK06108
414684008142	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
414684008143	pyridoxal 5'-phosphate binding site [chemical binding]; other site
414684008144	homodimer interface [polypeptide binding]; other site
414684008145	catalytic residue [active]
414684008146	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
414684008147	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
414684008148	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
414684008149	dimer interface [polypeptide binding]; other site
414684008150	active site
414684008151	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
414684008152	catalytic residues [active]
414684008153	substrate binding site [chemical binding]; other site
414684008154	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
414684008155	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
414684008156	Walker A/P-loop; other site
414684008157	ATP binding site [chemical binding]; other site
414684008158	Q-loop/lid; other site
414684008159	ABC transporter signature motif; other site
414684008160	Walker B; other site
414684008161	D-loop; other site
414684008162	H-loop/switch region; other site
414684008163	CcmB protein; Region: CcmB; cl17444
414684008164	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
414684008165	Peptidase family M23; Region: Peptidase_M23; pfam01551
414684008166	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
414684008167	heme exporter protein CcmC; Region: ccmC; TIGR01191
414684008168	Heme exporter protein D (CcmD); Region: CcmD; cl11475
414684008169	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
414684008170	cytochrome c-type biogenesis protein CcmF;part of the cytochrome c-type biogenesis protein cluster
414684008171	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
414684008172	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
414684008173	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
414684008174	catalytic residues [active]
414684008175	central insert; other site
414684008176	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
414684008177	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
414684008178	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
414684008179	TPR motif; other site
414684008180	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
414684008181	Cache domain; Region: Cache_1; pfam02743
414684008182	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
414684008183	dimerization interface [polypeptide binding]; other site
414684008184	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
414684008185	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684008186	dimer interface [polypeptide binding]; other site
414684008187	putative CheW interface [polypeptide binding]; other site
414684008188	Response regulator receiver domain; Region: Response_reg; pfam00072
414684008189	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684008190	active site
414684008191	phosphorylation site [posttranslational modification]
414684008192	intermolecular recognition site; other site
414684008193	dimerization interface [polypeptide binding]; other site
414684008194	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
414684008195	Protein of unknown function (DUF808); Region: DUF808; cl01002
414684008196	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
414684008197	Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974
414684008198	active site
414684008199	acyl-activating enzyme (AAE) consensus motif; other site
414684008200	putative CoA binding site [chemical binding]; other site
414684008201	AMP binding site [chemical binding]; other site
414684008202	short chain dehydrogenase; Provisional; Region: PRK08278
414684008203	human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762
414684008204	NAD(P) binding site [chemical binding]; other site
414684008205	homodimer interface [polypeptide binding]; other site
414684008206	active site
414684008207	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
414684008208	putative binding surface; other site
414684008209	active site
414684008210	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
414684008211	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
414684008212	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
414684008213	putative ligand binding site [chemical binding]; other site
414684008214	Predicted methyltransferases [General function prediction only]; Region: COG0313
414684008215	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
414684008216	putative SAM binding site [chemical binding]; other site
414684008217	putative homodimer interface [polypeptide binding]; other site
414684008218	Uncharacterized protein family UPF0102; Region: UPF0102; cl00516
414684008219	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
414684008220	methylthioribose kinase; Reviewed; Region: mtnK; PRK09550
414684008221	Phosphotransferase enzyme family; Region: APH; pfam01636
414684008222	flagellar basal-body rod protein FlgC; Region: FlgC; TIGR01395
414684008223	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
414684008224	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
414684008225	Flavoprotein; Region: Flavoprotein; pfam02441
414684008226	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
414684008227	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
414684008228	trimer interface [polypeptide binding]; other site
414684008229	active site
414684008230	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
414684008231	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
414684008232	oligomeric interface; other site
414684008233	putative active site [active]
414684008234	homodimer interface [polypeptide binding]; other site
414684008235	Rrf2 family protein; Region: rrf2_super; TIGR00738
414684008236	Transcriptional regulator; Region: Rrf2; pfam02082
414684008237	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
414684008238	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
414684008239	dimer interface [polypeptide binding]; other site
414684008240	pyridoxal 5'-phosphate binding site [chemical binding]; other site
414684008241	catalytic residue [active]
414684008242	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
414684008243	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
414684008244	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
414684008245	ATP binding site [chemical binding]; other site
414684008246	substrate interface [chemical binding]; other site
414684008247	DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453
414684008248	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
414684008249	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
414684008250	DNA binding site [nucleotide binding]
414684008251	catalytic residue [active]
414684008252	H2TH interface [polypeptide binding]; other site
414684008253	putative catalytic residues [active]
414684008254	turnover-facilitating residue; other site
414684008255	intercalation triad [nucleotide binding]; other site
414684008256	8OG recognition residue [nucleotide binding]; other site
414684008257	putative reading head residues; other site
414684008258	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
414684008259	enoyl-CoA hydratase; Provisional; Region: PRK05862
414684008260	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
414684008261	substrate binding site [chemical binding]; other site
414684008262	oxyanion hole (OAH) forming residues; other site
414684008263	trimer interface [polypeptide binding]; other site
414684008264	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
414684008265	DnaA N-terminal domain; Region: DnaA_N; pfam11638
414684008266	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
414684008267	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
414684008268	Walker A motif; other site
414684008269	ATP binding site [chemical binding]; other site
414684008270	Walker B motif; other site
414684008271	arginine finger; other site
414684008272	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
414684008273	DnaA box-binding interface [nucleotide binding]; other site
414684008274	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
414684008275	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684008276	dimer interface [polypeptide binding]; other site
414684008277	phosphorylation site [posttranslational modification]
414684008278	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684008279	ATP binding site [chemical binding]; other site
414684008280	Mg2+ binding site [ion binding]; other site
414684008281	G-X-G motif; other site
414684008282	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
414684008283	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
414684008284	Histidine kinase; Region: HisKA_2; pfam07568
414684008285	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684008286	ATP binding site [chemical binding]; other site
414684008287	Mg2+ binding site [ion binding]; other site
414684008288	G-X-G motif; other site
414684008289	Phasin protein; Region: Phasin_2; cl11491
414684008290	DNA polymerase III subunit beta; Validated; Region: PRK05643
414684008291	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
414684008292	putative DNA binding surface [nucleotide binding]; other site
414684008293	dimer interface [polypeptide binding]; other site
414684008294	beta-clamp/clamp loader binding surface; other site
414684008295	beta-clamp/translesion DNA polymerase binding surface; other site
414684008296	recombination protein F; Reviewed; Region: recF; PRK00064
414684008297	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
414684008298	Walker A/P-loop; other site
414684008299	ATP binding site [chemical binding]; other site
414684008300	Q-loop/lid; other site
414684008301	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
414684008302	ABC transporter signature motif; other site
414684008303	Walker B; other site
414684008304	D-loop; other site
414684008305	H-loop/switch region; other site
414684008306	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
414684008307	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684008308	Mg2+ binding site [ion binding]; other site
414684008309	G-X-G motif; other site
414684008310	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
414684008311	anchoring element; other site
414684008312	dimer interface [polypeptide binding]; other site
414684008313	ATP binding site [chemical binding]; other site
414684008314	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
414684008315	active site
414684008316	putative metal-binding site [ion binding]; other site
414684008317	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
414684008318	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
414684008319	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
414684008320	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
414684008321	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684008322	dimer interface [polypeptide binding]; other site
414684008323	putative CheW interface [polypeptide binding]; other site
414684008324	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
414684008325	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
414684008326	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
414684008327	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
414684008328	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
414684008329	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
414684008330	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
414684008331	HNH endonuclease; Region: HNH_2; pfam13391
414684008332	MarR family; Region: MarR_2; pfam12802
414684008333	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
414684008334	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
414684008335	metal ion-dependent adhesion site (MIDAS); other site
414684008336	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
414684008337	sequence-specific DNA binding site [nucleotide binding]; other site
414684008338	salt bridge; other site
414684008339	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
414684008340	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
414684008341	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
414684008342	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
414684008343	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
414684008344	HSP70 interaction site [polypeptide binding]; other site
414684008345	EamA-like transporter family; Region: EamA; pfam00892
414684008346	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
414684008347	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
414684008348	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
414684008349	Abi-like protein; Region: Abi_2; pfam07751
414684008350	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
414684008351	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
414684008352	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684008353	dimer interface [polypeptide binding]; other site
414684008354	putative CheW interface [polypeptide binding]; other site
414684008355	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
414684008356	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
414684008357	ABC transporter ATP-binding protein, putative
414684008358	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
414684008359	active site
414684008360	catalytic triad [active]
414684008361	oxyanion hole [active]
414684008362	switch loop; other site
414684008363	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398
414684008364	FIST N domain; Region: FIST; pfam08495
414684008365	FIST C domain; Region: FIST_C; pfam10442
414684008366	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
414684008367	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
414684008368	active site
414684008369	catalytic tetrad [active]
414684008370	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
414684008371	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
414684008372	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
414684008373	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
414684008374	non-specific DNA binding site [nucleotide binding]; other site
414684008375	salt bridge; other site
414684008376	sequence-specific DNA binding site [nucleotide binding]; other site
414684008377	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
414684008378	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
414684008379	active site
414684008380	dimer interface [polypeptide binding]; other site
414684008381	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
414684008382	active site
414684008383	membrane ATPase/protein kinase; Provisional; Region: PRK09435
414684008384	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
414684008385	Walker A; other site
414684008386	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
414684008387	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
414684008388	active site
414684008389	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
414684008390	ThiS interaction site; other site
414684008391	putative active site [active]
414684008392	tetramer interface [polypeptide binding]; other site
414684008393	Ubiquitin-like proteins; Region: UBQ; cl00155
414684008394	charged pocket; other site
414684008395	hydrophobic patch; other site
414684008396	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
414684008397	hydroxyglutarate oxidase; Provisional; Region: PRK11728
414684008398	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
414684008399	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
414684008400	HipA N-terminal domain; Region: Couple_hipA; pfam13657
414684008401	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
414684008402	non-specific DNA binding site [nucleotide binding]; other site
414684008403	salt bridge; other site
414684008404	sequence-specific DNA binding site [nucleotide binding]; other site
414684008405	hypothetical protein; Region: PHA00661
414684008406	hypothetical protein; Region: PHA00661
414684008407	hypothetical protein; Region: PHA00662
414684008408	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
414684008409	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
414684008410	active site
414684008411	substrate binding site [chemical binding]; other site
414684008412	coenzyme B12 binding site [chemical binding]; other site
414684008413	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
414684008414	B12 binding site [chemical binding]; other site
414684008415	cobalt ligand [ion binding]; other site
414684008416	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
414684008417	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
414684008418	active site
414684008419	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
414684008420	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
414684008421	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
414684008422	catalytic site [active]
414684008423	TAP-like protein; Region: Abhydrolase_4; pfam08386
414684008424	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
414684008425	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
414684008426	substrate binding pocket [chemical binding]; other site
414684008427	membrane-bound complex binding site; other site
414684008428	hinge residues; other site
414684008429	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
414684008430	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
414684008431	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
414684008432	putative PBP binding loops; other site
414684008433	dimer interface [polypeptide binding]; other site
414684008434	ABC-ATPase subunit interface; other site
414684008435	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
414684008436	dimer interface [polypeptide binding]; other site
414684008437	conserved gate region; other site
414684008438	putative PBP binding loops; other site
414684008439	ABC-ATPase subunit interface; other site
414684008440	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
414684008441	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
414684008442	Walker A/P-loop; other site
414684008443	ATP binding site [chemical binding]; other site
414684008444	Q-loop/lid; other site
414684008445	ABC transporter signature motif; other site
414684008446	Walker B; other site
414684008447	D-loop; other site
414684008448	H-loop/switch region; other site
414684008449	Protein of unknown function (DUF497); Region: DUF497; pfam04365
414684008450	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
414684008451	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
414684008452	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
414684008453	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
414684008454	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
414684008455	Cadherin repeat-like domain; Region: CA_like; cl15786
414684008456	Ca2+ binding site [ion binding]; other site
414684008457	Bacterial Ig-like domain; Region: Big_5; pfam13205
414684008458	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
414684008459	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
414684008460	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
414684008461	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
414684008462	Ca2+ binding site [ion binding]; other site
414684008463	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
414684008464	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
414684008465	dimerization interface [polypeptide binding]; other site
414684008466	ligand binding site [chemical binding]; other site
414684008467	NADP binding site [chemical binding]; other site
414684008468	catalytic site [active]
414684008469	Bacterial SH3 domain; Region: SH3_4; pfam06347
414684008470	Bacterial SH3 domain; Region: SH3_4; pfam06347
414684008471	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
414684008472	intersubunit interface [polypeptide binding]; other site
414684008473	active site
414684008474	Zn2+ binding site [ion binding]; other site
414684008475	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
414684008476	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
414684008477	active site
414684008478	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
414684008479	Domain of unknown function (DUF4411); Region: DUF4411; pfam14367
414684008480	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
414684008481	non-specific DNA binding site [nucleotide binding]; other site
414684008482	salt bridge; other site
414684008483	sequence-specific DNA binding site [nucleotide binding]; other site
414684008484	Domain of unknown function (DUF955); Region: DUF955; cl01076
414684008485	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
414684008486	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
414684008487	conserved hypothetical protein; Region: MG423; TIGR00649
414684008488	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
414684008489	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
414684008490	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
414684008491	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
414684008492	active site
414684008493	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
414684008494	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684008495	S-adenosylmethionine binding site [chemical binding]; other site
414684008496	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
414684008497	RibD C-terminal domain; Region: RibD_C; cl17279
414684008498	Peptidase family M48; Region: Peptidase_M48; cl12018
414684008499	Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987
414684008500	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
414684008501	putative FMN binding site [chemical binding]; other site
414684008502	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
414684008503	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
414684008504	Substrate binding site; other site
414684008505	metal-binding site
414684008506	aminoglycoside phosphotransferase, pseudogene;identified by match to protein family HMM PF00005
414684008507	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
414684008508	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
414684008509	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
414684008510	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
414684008511	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
414684008512	Integral membrane protein (DUF2244); Region: DUF2244; pfam10003
414684008513	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
414684008514	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
414684008515	dimer interface [polypeptide binding]; other site
414684008516	putative PBP binding regions; other site
414684008517	ABC-ATPase subunit  interface; other site
414684008518	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
414684008519	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
414684008520	ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531
414684008521	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
414684008522	metal binding site [ion binding]; metal-binding site
414684008523	dihydrodipicolinate reductase; Provisional; Region: PRK00048
414684008524	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
414684008525	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
414684008526	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
414684008527	putative active site [active]
414684008528	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
414684008529	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
414684008530	dimer interface [polypeptide binding]; other site
414684008531	PYR/PP interface [polypeptide binding]; other site
414684008532	TPP binding site [chemical binding]; other site
414684008533	substrate binding site [chemical binding]; other site
414684008534	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
414684008535	TPP-binding site; other site
414684008536	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
414684008537	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
414684008538	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
414684008539	substrate binding site [chemical binding]; other site
414684008540	threonine dehydratase; Provisional; Region: PRK07334
414684008541	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
414684008542	tetramer interface [polypeptide binding]; other site
414684008543	pyridoxal 5'-phosphate binding site [chemical binding]; other site
414684008544	catalytic residue [active]
414684008545	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
414684008546	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
414684008547	HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4
414684008548	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
414684008549	active site
414684008550	motif I; other site
414684008551	motif II; other site
414684008552	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
414684008553	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
414684008554	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
414684008555	Moco binding site; other site
414684008556	metal coordination site [ion binding]; other site
414684008557	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
414684008558	Mechanosensitive ion channel; Region: MS_channel; pfam00924
414684008559	Dihydroneopterin aldolase; Region: FolB; smart00905
414684008560	active site
414684008561	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
414684008562	DNA methylase; Region: N6_N4_Mtase; pfam01555
414684008563	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
414684008564	RNA/DNA hybrid binding site [nucleotide binding]; other site
414684008565	active site
414684008566	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
414684008567	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
414684008568	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
414684008569	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
414684008570	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
414684008571	FeS/SAM binding site; other site
414684008572	HemN C-terminal domain; Region: HemN_C; pfam06969
414684008573	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
414684008574	active site
414684008575	motif I; other site
414684008576	motif II; other site
414684008577	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
414684008578	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
414684008579	FeS/SAM binding site; other site
414684008580	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14609
414684008581	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
414684008582	binding surface
414684008583	TPR repeat; Region: TPR_11; pfam13414
414684008584	TPR motif; other site
414684008585	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
414684008586	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
414684008587	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
414684008588	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
414684008589	Fe-S cluster binding site [ion binding]; other site
414684008590	active site
414684008591	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
414684008592	MPT binding site; other site
414684008593	trimer interface [polypeptide binding]; other site
414684008594	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
414684008595	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
414684008596	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
414684008597	active site
414684008598	Predicted transcriptional regulators [Transcription]; Region: COG1695
414684008599	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
414684008600	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981
414684008601	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
414684008602	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
414684008603	Walker A/P-loop; other site
414684008604	ATP binding site [chemical binding]; other site
414684008605	Q-loop/lid; other site
414684008606	ABC transporter signature motif; other site
414684008607	Walker B; other site
414684008608	D-loop; other site
414684008609	H-loop/switch region; other site
414684008610	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
414684008611	Sel1-like repeats; Region: SEL1; smart00671
414684008612	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
414684008613	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
414684008614	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
414684008615	active site
414684008616	dimer interface [polypeptide binding]; other site
414684008617	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
414684008618	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
414684008619	active site
414684008620	FMN binding site [chemical binding]; other site
414684008621	substrate binding site [chemical binding]; other site
414684008622	3Fe-4S cluster binding site [ion binding]; other site
414684008623	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
414684008624	domain interface; other site
414684008625	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
414684008626	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
414684008627	putative C-terminal domain interface [polypeptide binding]; other site
414684008628	putative GSH binding site (G-site) [chemical binding]; other site
414684008629	putative dimer interface [polypeptide binding]; other site
414684008630	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
414684008631	N-terminal domain interface [polypeptide binding]; other site
414684008632	dimer interface [polypeptide binding]; other site
414684008633	substrate binding pocket (H-site) [chemical binding]; other site
414684008634	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
414684008635	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
414684008636	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
414684008637	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
414684008638	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
414684008639	putative NAD(P) binding site [chemical binding]; other site
414684008640	active site
414684008641	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
414684008642	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
414684008643	catalytic site [active]
414684008644	putative active site [active]
414684008645	putative substrate binding site [chemical binding]; other site
414684008646	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
414684008647	OstA-like protein; Region: OstA; cl00844
414684008648	OstA-like protein; Region: OstA; cl00844
414684008649	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
414684008650	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
414684008651	Walker A/P-loop; other site
414684008652	ATP binding site [chemical binding]; other site
414684008653	Q-loop/lid; other site
414684008654	ABC transporter signature motif; other site
414684008655	Walker B; other site
414684008656	D-loop; other site
414684008657	H-loop/switch region; other site
414684008658	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
414684008659	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
414684008660	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
414684008661	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
414684008662	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
414684008663	30S subunit binding site; other site
414684008664	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
414684008665	active site
414684008666	phosphorylation site [posttranslational modification]
414684008667	Protein of unknown function (DUF1150); Region: DUF1150; pfam06620
414684008668	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
414684008669	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
414684008670	putative dimer interface [polypeptide binding]; other site
414684008671	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
414684008672	substrate binding pocket [chemical binding]; other site
414684008673	membrane-bound complex binding site; other site
414684008674	flagellar motor switch protein FliN; Region: fliN; TIGR02480
414684008675	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
414684008676	Domain of unknown function (DUF4365); Region: DUF4365; pfam14280
414684008677	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
414684008678	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
414684008679	N-terminal plug; other site
414684008680	ligand-binding site [chemical binding]; other site
414684008681	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
414684008682	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
414684008683	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
414684008684	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
414684008685	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
414684008686	Na binding site [ion binding]; other site
414684008687	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
414684008688	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
414684008689	ligand binding site [chemical binding]; other site
414684008690	flexible hinge region; other site
414684008691	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
414684008692	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
414684008693	metal binding triad; other site
414684008694	Curli production assembly/transport component CsgG; Region: CsgG; cl17434
414684008695	Bacterial SH3 domain; Region: SH3_3; pfam08239
414684008696	photoactive yellow protein; Region: photo_yellow; TIGR02373
414684008697	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
414684008698	GAF domain; Region: GAF; pfam01590
414684008699	Phytochrome region; Region: PHY; pfam00360
414684008700	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684008701	dimer interface [polypeptide binding]; other site
414684008702	phosphorylation site [posttranslational modification]
414684008703	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684008704	ATP binding site [chemical binding]; other site
414684008705	Mg2+ binding site [ion binding]; other site
414684008706	G-X-G motif; other site
414684008707	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
414684008708	HlyD family secretion protein; Region: HlyD_3; pfam13437
414684008709	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
414684008710	Protein export membrane protein; Region: SecD_SecF; cl14618
414684008711	Protein export membrane protein; Region: SecD_SecF; cl14618
414684008712	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
414684008713	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
414684008714	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
414684008715	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
414684008716	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
414684008717	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
414684008718	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
414684008719	pseudouridine synthase; Region: TIGR00093
414684008720	active site
414684008721	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
414684008722	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
414684008723	DNA-binding site [nucleotide binding]; DNA binding site
414684008724	UTRA domain; Region: UTRA; pfam07702
414684008725	imidazolonepropionase; Validated; Region: PRK09356
414684008726	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
414684008727	active site
414684008728	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
414684008729	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
414684008730	active site
414684008731	urocanate hydratase; Provisional; Region: PRK05414
414684008732	N-formylglutamate amidohydrolase; Region: FGase; cl01522
414684008733	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
414684008734	active sites [active]
414684008735	tetramer interface [polypeptide binding]; other site
414684008736	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
414684008737	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
414684008738	NAD(P) binding site [chemical binding]; other site
414684008739	catalytic residues [active]
414684008740	short chain dehydrogenase; Provisional; Region: PRK06181
414684008741	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
414684008742	putative NAD(P) binding site [chemical binding]; other site
414684008743	active site
414684008744	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
414684008745	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
414684008746	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
414684008747	HlyD family secretion protein; Region: HlyD_3; pfam13437
414684008748	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
414684008749	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
414684008750	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
414684008751	TrkA-C domain; Region: TrkA_C; pfam02080
414684008752	TrkA-C domain; Region: TrkA_C; pfam02080
414684008753	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
414684008754	FOG: CBS domain [General function prediction only]; Region: COG0517
414684008755	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
414684008756	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
414684008757	Zinc-finger domain; Region: zf-CHCC; cl01821
414684008758	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
414684008759	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
414684008760	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
414684008761	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
414684008762	Walker A/P-loop; other site
414684008763	ATP binding site [chemical binding]; other site
414684008764	Q-loop/lid; other site
414684008765	ABC transporter signature motif; other site
414684008766	Walker B; other site
414684008767	D-loop; other site
414684008768	H-loop/switch region; other site
414684008769	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
414684008770	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
414684008771	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
414684008772	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
414684008773	CoA-transferase family III; Region: CoA_transf_3; pfam02515
414684008774	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
414684008775	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
414684008776	FMN binding site [chemical binding]; other site
414684008777	substrate binding site [chemical binding]; other site
414684008778	putative catalytic residue [active]
414684008779	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
414684008780	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
414684008781	Malic enzyme, N-terminal domain; Region: malic; pfam00390
414684008782	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
414684008783	putative NAD(P) binding site [chemical binding]; other site
414684008784	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
414684008785	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
414684008786	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684008787	dimer interface [polypeptide binding]; other site
414684008788	phosphorylation site [posttranslational modification]
414684008789	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684008790	ATP binding site [chemical binding]; other site
414684008791	Mg2+ binding site [ion binding]; other site
414684008792	G-X-G motif; other site
414684008793	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
414684008794	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
414684008795	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
414684008796	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
414684008797	dimer interface [polypeptide binding]; other site
414684008798	conserved gate region; other site
414684008799	putative PBP binding loops; other site
414684008800	ABC-ATPase subunit interface; other site
414684008801	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
414684008802	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
414684008803	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
414684008804	ABC-ATPase subunit interface; other site
414684008805	phosphate transporter ATP-binding protein; Provisional; Region: PRK14235
414684008806	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
414684008807	Walker A/P-loop; other site
414684008808	ATP binding site [chemical binding]; other site
414684008809	Q-loop/lid; other site
414684008810	ABC transporter signature motif; other site
414684008811	Walker B; other site
414684008812	D-loop; other site
414684008813	H-loop/switch region; other site
414684008814	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
414684008815	PhoU domain; Region: PhoU; pfam01895
414684008816	PhoU domain; Region: PhoU; pfam01895
414684008817	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
414684008818	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684008819	active site
414684008820	phosphorylation site [posttranslational modification]
414684008821	intermolecular recognition site; other site
414684008822	dimerization interface [polypeptide binding]; other site
414684008823	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
414684008824	DNA binding site [nucleotide binding]
414684008825	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
414684008826	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684008827	S-adenosylmethionine binding site [chemical binding]; other site
414684008828	ABC1 family; Region: ABC1; cl17513
414684008829	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
414684008830	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
414684008831	active site
414684008832	NTP binding site [chemical binding]; other site
414684008833	metal binding triad [ion binding]; metal-binding site
414684008834	antibiotic binding site [chemical binding]; other site
414684008835	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
414684008836	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
414684008837	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
414684008838	putative NAD(P) binding site [chemical binding]; other site
414684008839	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
414684008840	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
414684008841	C-terminal domain interface [polypeptide binding]; other site
414684008842	GSH binding site (G-site) [chemical binding]; other site
414684008843	dimer interface [polypeptide binding]; other site
414684008844	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
414684008845	N-terminal domain interface [polypeptide binding]; other site
414684008846	dimer interface [polypeptide binding]; other site
414684008847	substrate binding pocket (H-site) [chemical binding]; other site
414684008848	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684008849	S-adenosylmethionine binding site [chemical binding]; other site
414684008850	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
414684008851	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
414684008852	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
414684008853	Coenzyme A binding pocket [chemical binding]; other site
414684008854	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
414684008855	dimer interface [polypeptide binding]; other site
414684008856	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
414684008857	HlyD family secretion protein; Region: HlyD_3; pfam13437
414684008858	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
414684008859	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
414684008860	Walker A/P-loop; other site
414684008861	ATP binding site [chemical binding]; other site
414684008862	Q-loop/lid; other site
414684008863	ABC transporter signature motif; other site
414684008864	Walker B; other site
414684008865	D-loop; other site
414684008866	H-loop/switch region; other site
414684008867	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
414684008868	FtsX-like permease family; Region: FtsX; pfam02687
414684008869	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
414684008870	FtsX-like permease family; Region: FtsX; pfam02687
414684008871	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
414684008872	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
414684008873	dimer interface [polypeptide binding]; other site
414684008874	acyl-activating enzyme (AAE) consensus motif; other site
414684008875	putative active site [active]
414684008876	AMP binding site [chemical binding]; other site
414684008877	putative CoA binding site [chemical binding]; other site
414684008878	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
414684008879	Phage Tail Collar Domain; Region: Collar; pfam07484
414684008880	Uncharacterized conserved protein [Function unknown]; Region: COG1742
414684008881	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
414684008882	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
414684008883	Walker A motif; other site
414684008884	ATP binding site [chemical binding]; other site
414684008885	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
414684008886	Walker B motif; other site
414684008887	arginine finger; other site
414684008888	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
414684008889	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
414684008890	active site
414684008891	HslU subunit interaction site [polypeptide binding]; other site
414684008892	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
414684008893	4-fold oligomerization interface [polypeptide binding]; other site
414684008894	putative active site pocket [active]
414684008895	metal binding residues [ion binding]; metal-binding site
414684008896	3-fold/trimer interface [polypeptide binding]; other site
414684008897	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
414684008898	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
414684008899	putative active site [active]
414684008900	oxyanion strand; other site
414684008901	catalytic triad [active]
414684008902	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
414684008903	Coenzyme A binding pocket [chemical binding]; other site
414684008904	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
414684008905	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
414684008906	catalytic residues [active]
414684008907	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
414684008908	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
414684008909	substrate binding site [chemical binding]; other site
414684008910	glutamase interaction surface [polypeptide binding]; other site
414684008911	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
414684008912	metal binding site [ion binding]; metal-binding site
414684008913	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
414684008914	nucleotide binding site/active site [active]
414684008915	HIT family signature motif; other site
414684008916	catalytic residue [active]
414684008917	L-lactate permease; Region: Lactate_perm; cl00701
414684008918	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
414684008919	L-lactate permease; Region: Lactate_perm; cl00701
414684008920	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
414684008921	MarC family integral membrane protein; Region: MarC; cl00919
414684008922	Predicted ATPase [General function prediction only]; Region: COG3911
414684008923	AAA domain; Region: AAA_28; pfam13521
414684008924	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
414684008925	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
414684008926	active site
414684008927	nucleotide binding site [chemical binding]; other site
414684008928	HIGH motif; other site
414684008929	KMSKS motif; other site
414684008930	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
414684008931	Transglycosylase; Region: Transgly; cl17702
414684008932	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
414684008933	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
414684008934	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684008935	dimer interface [polypeptide binding]; other site
414684008936	phosphorylation site [posttranslational modification]
414684008937	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684008938	ATP binding site [chemical binding]; other site
414684008939	Mg2+ binding site [ion binding]; other site
414684008940	G-X-G motif; other site
414684008941	D-alanyl-D-alanine carboxypeptidase, pseudogene;identified by match to protein family HMM PF00529
414684008942	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
414684008943	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
414684008944	tellurite resistance protein terB; Region: terB; cd07176
414684008945	putative metal binding site [ion binding]; other site
414684008946	Predicted transcriptional regulator [Transcription]; Region: COG2932
414684008947	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
414684008948	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
414684008949	Catalytic site [active]
414684008950	Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236
414684008951	hypothetical protein; Region: PHA00670
414684008952	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
414684008953	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
414684008954	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330
414684008955	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
414684008956	active site
414684008957	catalytic site [active]
414684008958	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
414684008959	DNA-binding site [nucleotide binding]; DNA binding site
414684008960	RNA-binding motif; other site
414684008961	Protein of unknown function (DUF533); Region: DUF533; pfam04391
414684008962	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
414684008963	putative metal binding site [ion binding]; other site
414684008964	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
414684008965	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
414684008966	putative substrate translocation pore; other site
414684008967	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
414684008968	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
414684008969	N-terminal plug; other site
414684008970	ligand-binding site [chemical binding]; other site
414684008971	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cl08187
414684008972	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
414684008973	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
414684008974	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
414684008975	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cl17348
414684008976	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608
414684008977	CRISPR-associated protein Cse2 (CRISPR_cse2); Region: CRISPR_Cse2; pfam09485
414684008978	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044
414684008979	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
414684008980	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
414684008981	PAS domain; Region: PAS_9; pfam13426
414684008982	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684008983	PAS domain; Region: PAS_9; pfam13426
414684008984	putative active site [active]
414684008985	heme pocket [chemical binding]; other site
414684008986	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
414684008987	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684008988	dimer interface [polypeptide binding]; other site
414684008989	phosphorylation site [posttranslational modification]
414684008990	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684008991	ATP binding site [chemical binding]; other site
414684008992	Mg2+ binding site [ion binding]; other site
414684008993	G-X-G motif; other site
414684008994	Response regulator receiver domain; Region: Response_reg; pfam00072
414684008995	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684008996	active site
414684008997	phosphorylation site [posttranslational modification]
414684008998	intermolecular recognition site; other site
414684008999	dimerization interface [polypeptide binding]; other site
414684009000	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
414684009001	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
414684009002	dimer interface [polypeptide binding]; other site
414684009003	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
414684009004	active site
414684009005	Fe binding site [ion binding]; other site
414684009006	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
414684009007	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
414684009008	putative DNA binding site [nucleotide binding]; other site
414684009009	putative Zn2+ binding site [ion binding]; other site
414684009010	AsnC family; Region: AsnC_trans_reg; pfam01037
414684009011	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
414684009012	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
414684009013	cofactor binding site; other site
414684009014	metal binding site [ion binding]; metal-binding site
414684009015	Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains [Cell envelope biogenesis, outer membrane]; Region: GlmS; COG0449
414684009016	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
414684009017	active site
414684009018	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
414684009019	dimer interface [polypeptide binding]; other site
414684009020	active site
414684009021	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
414684009022	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
414684009023	active site
414684009024	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
414684009025	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684009026	dimer interface [polypeptide binding]; other site
414684009027	phosphorylation site [posttranslational modification]
414684009028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684009029	ATP binding site [chemical binding]; other site
414684009030	G-X-G motif; other site
414684009031	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
414684009032	dimer interface [polypeptide binding]; other site
414684009033	conserved gate region; other site
414684009034	ABC-ATPase subunit interface; other site
414684009035	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
414684009036	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
414684009037	Walker A/P-loop; other site
414684009038	ATP binding site [chemical binding]; other site
414684009039	Q-loop/lid; other site
414684009040	ABC transporter signature motif; other site
414684009041	Walker B; other site
414684009042	D-loop; other site
414684009043	H-loop/switch region; other site
414684009044	NIL domain; Region: NIL; pfam09383
414684009045	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
414684009046	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
414684009047	Transcriptional regulator [Transcription]; Region: LysR; COG0583
414684009048	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
414684009049	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
414684009050	putative effector binding pocket; other site
414684009051	putative dimerization interface [polypeptide binding]; other site
414684009052	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
414684009053	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
414684009054	active site
414684009055	catalytic tetrad [active]
414684009056	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
414684009057	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
414684009058	putative NAD(P) binding site [chemical binding]; other site
414684009059	putative substrate binding site [chemical binding]; other site
414684009060	catalytic Zn binding site [ion binding]; other site
414684009061	structural Zn binding site [ion binding]; other site
414684009062	dimer interface [polypeptide binding]; other site
414684009063	GAF domain; Region: GAF; cl17456
414684009064	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
414684009065	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
414684009066	metal binding site [ion binding]; metal-binding site
414684009067	active site
414684009068	I-site; other site
414684009069	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
414684009070	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
414684009071	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
414684009072	ATP binding site [chemical binding]; other site
414684009073	active site
414684009074	substrate binding site [chemical binding]; other site
414684009075	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
414684009076	SlyX; Region: SlyX; pfam04102
414684009077	aconitate hydratase; Validated; Region: PRK09277
414684009078	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
414684009079	substrate binding site [chemical binding]; other site
414684009080	ligand binding site [chemical binding]; other site
414684009081	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
414684009082	substrate binding site [chemical binding]; other site
414684009083	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
414684009084	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
414684009085	dimer interface [polypeptide binding]; other site
414684009086	conserved gate region; other site
414684009087	putative PBP binding loops; other site
414684009088	ABC-ATPase subunit interface; other site
414684009089	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
414684009090	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
414684009091	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
414684009092	dimer interface [polypeptide binding]; other site
414684009093	conserved gate region; other site
414684009094	putative PBP binding loops; other site
414684009095	ABC-ATPase subunit interface; other site
414684009096	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
414684009097	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
414684009098	Walker A/P-loop; other site
414684009099	ATP binding site [chemical binding]; other site
414684009100	Q-loop/lid; other site
414684009101	ABC transporter signature motif; other site
414684009102	Walker B; other site
414684009103	D-loop; other site
414684009104	H-loop/switch region; other site
414684009105	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
414684009106	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
414684009107	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
414684009108	Walker A/P-loop; other site
414684009109	ATP binding site [chemical binding]; other site
414684009110	Q-loop/lid; other site
414684009111	ABC transporter signature motif; other site
414684009112	Walker B; other site
414684009113	D-loop; other site
414684009114	H-loop/switch region; other site
414684009115	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
414684009116	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
414684009117	Putative esterase; Region: Esterase; pfam00756
414684009118	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
414684009119	nudix motif; other site
414684009120	Predicted small secreted protein [Function unknown]; Region: COG5510
414684009121	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
414684009122	Na2 binding site [ion binding]; other site
414684009123	putative substrate binding site 1 [chemical binding]; other site
414684009124	Na binding site 1 [ion binding]; other site
414684009125	putative substrate binding site 2 [chemical binding]; other site
414684009126	Domain of unknown function (DUF307); Region: DUF307; pfam03733
414684009127	hypothetical protein; Provisional; Region: PRK11770
414684009128	Domain of unknown function (DUF307); Region: DUF307; pfam03733
414684009129	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
414684009130	Phosphoglycerate kinase; Region: PGK; pfam00162
414684009131	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
414684009132	substrate binding site [chemical binding]; other site
414684009133	hinge regions; other site
414684009134	ADP binding site [chemical binding]; other site
414684009135	catalytic site [active]
414684009136	MgtC family; Region: MgtC; pfam02308
414684009137	Protein of unknown function DUF45; Region: DUF45; pfam01863
414684009138	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
414684009139	EamA-like transporter family; Region: EamA; pfam00892
414684009140	EamA-like transporter family; Region: EamA; pfam00892
414684009141	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
414684009142	active site
414684009143	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
414684009144	adenylosuccinate lyase; Provisional; Region: PRK07492
414684009145	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
414684009146	tetramer interface [polypeptide binding]; other site
414684009147	active site
414684009148	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
414684009149	active site
414684009150	hypothetical protein; Reviewed; Region: PRK00024
414684009151	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
414684009152	MPN+ (JAMM) motif; other site
414684009153	Zinc-binding site [ion binding]; other site
414684009154	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
414684009155	active site
414684009156	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
414684009157	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
414684009158	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
414684009159	putative dimer interface [polypeptide binding]; other site
414684009160	N-terminal domain interface [polypeptide binding]; other site
414684009161	putative substrate binding pocket (H-site) [chemical binding]; other site
414684009162	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
414684009163	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
414684009164	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
414684009165	putative MPT binding site; other site
414684009166	Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663
414684009167	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
414684009168	bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469
414684009169	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
414684009170	putative ligand binding site [chemical binding]; other site
414684009171	NAD binding site [chemical binding]; other site
414684009172	dimerization interface [polypeptide binding]; other site
414684009173	catalytic site [active]
414684009174	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
414684009175	FlxA-like protein; Region: FlxA; pfam14282
414684009176	Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746
414684009177	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
414684009178	CHASE4 domain; Region: CHASE4; pfam05228
414684009179	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
414684009180	PAS domain; Region: PAS; smart00091
414684009181	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684009182	dimer interface [polypeptide binding]; other site
414684009183	phosphorylation site [posttranslational modification]
414684009184	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684009185	ATP binding site [chemical binding]; other site
414684009186	Mg2+ binding site [ion binding]; other site
414684009187	G-X-G motif; other site
414684009188	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
414684009189	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
414684009190	active site
414684009191	Cytochrome c2 [Energy production and conversion]; Region: COG3474
414684009192	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
414684009193	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
414684009194	Ligand binding site; other site
414684009195	oligomer interface; other site
414684009196	prephenate dehydratase; Provisional; Region: PRK11899
414684009197	Prephenate dehydratase; Region: PDT; pfam00800
414684009198	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
414684009199	putative L-Phe binding site [chemical binding]; other site
414684009200	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
414684009201	putative active site [active]
414684009202	Ap4A binding site [chemical binding]; other site
414684009203	nudix motif; other site
414684009204	putative metal binding site [ion binding]; other site
414684009205	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
414684009206	double-transmembrane region pseudogene;identified by match to protein family HMM PF02308
414684009207	double-transmembrane region pseudogene;identified by match to protein family HMM PF01863
414684009208	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
414684009209	Protein of unknown function DUF58; Region: DUF58; pfam01882
414684009210	MoxR-like ATPases [General function prediction only]; Region: COG0714
414684009211	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
414684009212	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
414684009213	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
414684009214	putative active site [active]
414684009215	putative CoA binding site [chemical binding]; other site
414684009216	nudix motif; other site
414684009217	metal binding site [ion binding]; metal-binding site
414684009218	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
414684009219	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
414684009220	active site
414684009221	NTP binding site [chemical binding]; other site
414684009222	metal binding triad [ion binding]; metal-binding site
414684009223	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
414684009224	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
414684009225	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752
414684009226	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
414684009227	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
414684009228	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
414684009229	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
414684009230	[2Fe-2S] cluster binding site [ion binding]; other site
414684009231	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
414684009232	Qi binding site; other site
414684009233	intrachain domain interface; other site
414684009234	interchain domain interface [polypeptide binding]; other site
414684009235	cytochrome b; Provisional; Region: CYTB; MTH00156
414684009236	heme bH binding site [chemical binding]; other site
414684009237	heme bL binding site [chemical binding]; other site
414684009238	Qo binding site; other site
414684009239	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
414684009240	interchain domain interface [polypeptide binding]; other site
414684009241	intrachain domain interface; other site
414684009242	Qi binding site; other site
414684009243	Qo binding site; other site
414684009244	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
414684009245	Cytochrome c; Region: Cytochrom_C; cl11414
414684009246	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
414684009247	GTP-binding protein YchF; Reviewed; Region: PRK09601
414684009248	YchF GTPase; Region: YchF; cd01900
414684009249	G1 box; other site
414684009250	GTP/Mg2+ binding site [chemical binding]; other site
414684009251	Switch I region; other site
414684009252	G2 box; other site
414684009253	Switch II region; other site
414684009254	G3 box; other site
414684009255	G4 box; other site
414684009256	G5 box; other site
414684009257	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
414684009258	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
414684009259	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
414684009260	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
414684009261	heme binding site [chemical binding]; other site
414684009262	ferroxidase pore; other site
414684009263	ferroxidase diiron center [ion binding]; other site
414684009264	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
414684009265	putative glutathione S-transferase; Provisional; Region: PRK10357
414684009266	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
414684009267	putative C-terminal domain interface [polypeptide binding]; other site
414684009268	putative GSH binding site (G-site) [chemical binding]; other site
414684009269	putative dimer interface [polypeptide binding]; other site
414684009270	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
414684009271	dimer interface [polypeptide binding]; other site
414684009272	N-terminal domain interface [polypeptide binding]; other site
414684009273	putative substrate binding pocket (H-site) [chemical binding]; other site
414684009274	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
414684009275	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
414684009276	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
414684009277	metal binding site [ion binding]; metal-binding site
414684009278	active site
414684009279	I-site; other site
414684009280	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
414684009281	Prostaglandin dehydrogenases; Region: PGDH; cd05288
414684009282	NAD(P) binding site [chemical binding]; other site
414684009283	substrate binding site [chemical binding]; other site
414684009284	dimer interface [polypeptide binding]; other site
414684009285	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
414684009286	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
414684009287	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
414684009288	dimerization interface [polypeptide binding]; other site
414684009289	substrate binding pocket [chemical binding]; other site
414684009290	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
414684009291	active site
414684009292	catalytic triad [active]
414684009293	oxyanion hole [active]
414684009294	Autotransporter beta-domain; Region: Autotransporter; smart00869
414684009295	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
414684009296	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
414684009297	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
414684009298	WHG domain; Region: WHG; pfam13305
414684009299	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
414684009300	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
414684009301	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
414684009302	Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
414684009303	Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
414684009304	PAS domain S-box; Region: sensory_box; TIGR00229
414684009305	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684009306	putative active site [active]
414684009307	heme pocket [chemical binding]; other site
414684009308	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684009309	PAS fold; Region: PAS_3; pfam08447
414684009310	putative active site [active]
414684009311	heme pocket [chemical binding]; other site
414684009312	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
414684009313	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
414684009314	metal binding site [ion binding]; metal-binding site
414684009315	active site
414684009316	I-site; other site
414684009317	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
414684009318	YcjX-like family, DUF463; Region: DUF463; pfam04317
414684009319	hypothetical protein; Provisional; Region: PRK05415
414684009320	Domain of unknown function (DUF697); Region: DUF697; cl12064
414684009321	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
414684009322	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
414684009323	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
414684009324	Protein of unknown function (DUF445); Region: DUF445; pfam04286
414684009325	FOG: CBS domain [General function prediction only]; Region: COG0517
414684009326	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
414684009327	PRC-barrel domain; Region: PRC; pfam05239
414684009328	uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837
414684009329	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
414684009330	Cl binding site [ion binding]; other site
414684009331	oligomer interface [polypeptide binding]; other site
414684009332	Protein of unknown function (DUF3224); Region: DUF3224; pfam11528
414684009333	Protein of unknown function (DUF1194); Region: DUF1194; pfam06707
414684009334	two-component response regulator; Provisional; Region: PRK09191
414684009335	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684009336	active site
414684009337	phosphorylation site [posttranslational modification]
414684009338	intermolecular recognition site; other site
414684009339	dimerization interface [polypeptide binding]; other site
414684009340	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
414684009341	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
414684009342	active site
414684009343	metal binding site [ion binding]; metal-binding site
414684009344	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
414684009345	BON domain; Region: BON; pfam04972
414684009346	DNA polymerase III beta subunit, central domain; Region: DNA_pol3_beta_2; pfam02767
414684009347	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
414684009348	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
414684009349	PAS fold; Region: PAS_4; pfam08448
414684009350	PAS domain S-box; Region: sensory_box; TIGR00229
414684009351	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
414684009352	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684009353	dimer interface [polypeptide binding]; other site
414684009354	phosphorylation site [posttranslational modification]
414684009355	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684009356	ATP binding site [chemical binding]; other site
414684009357	Mg2+ binding site [ion binding]; other site
414684009358	G-X-G motif; other site
414684009359	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684009360	active site
414684009361	phosphorylation site [posttranslational modification]
414684009362	intermolecular recognition site; other site
414684009363	dimerization interface [polypeptide binding]; other site
414684009364	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
414684009365	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
414684009366	active site
414684009367	metal binding site [ion binding]; metal-binding site
414684009368	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
414684009369	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
414684009370	active site
414684009371	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
414684009372	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
414684009373	Family description; Region: VCBS; pfam13517
414684009374	Family description; Region: VCBS; pfam13517
414684009375	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
414684009376	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
414684009377	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102
414684009378	Class I ribonucleotide reductase; Region: RNR_I; cd01679
414684009379	active site
414684009380	dimer interface [polypeptide binding]; other site
414684009381	catalytic residues [active]
414684009382	effector binding site; other site
414684009383	R2 peptide binding site; other site
414684009384	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
414684009385	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
414684009386	Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983
414684009387	CRISPR-associated protein; Region: DUF3692; pfam12469
414684009388	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853
414684009389	CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700
414684009390	CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075
414684009391	CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cd09682
414684009392	CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cl01317
414684009393	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
414684009394	CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436
414684009395	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732
414684009396	CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455
414684009397	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
414684009398	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
414684009399	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
414684009400	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
414684009401	Coenzyme A binding pocket [chemical binding]; other site
414684009402	Domain of unknown function DUF29; Region: DUF29; pfam01724
414684009403	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
414684009404	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
414684009405	Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663
414684009406	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
414684009407	dimer interface [polypeptide binding]; other site
414684009408	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
414684009409	putative radical transfer pathway; other site
414684009410	diiron center [ion binding]; other site
414684009411	tyrosyl radical; other site
414684009412	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
414684009413	EF-hand domain pair; Region: EF_hand_5; pfam13499
414684009414	Ca2+ binding site [ion binding]; other site
414684009415	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
414684009416	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
414684009417	active site
414684009418	motif I; other site
414684009419	motif II; other site
414684009420	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
414684009421	oligomerization interface [polypeptide binding]; other site
414684009422	active site
414684009423	metal binding site [ion binding]; metal-binding site
414684009424	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
414684009425	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
414684009426	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
414684009427	Switch I; other site
414684009428	Switch II; other site
414684009429	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
414684009430	septum formation inhibitor; Reviewed; Region: minC; PRK04804
414684009431	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
414684009432	Short C-terminal domain; Region: SHOCT; pfam09851
414684009433	PhoH-like protein; Region: PhoH; pfam02562
414684009434	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
414684009435	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
414684009436	NAD binding site [chemical binding]; other site
414684009437	dimer interface [polypeptide binding]; other site
414684009438	substrate binding site [chemical binding]; other site
414684009439	tetramer (dimer of dimers) interface [polypeptide binding]; other site
414684009440	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
414684009441	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
414684009442	Cu(I) binding site [ion binding]; other site
414684009443	Protein of unknown function (DUF461); Region: DUF461; pfam04314
414684009444	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
414684009445	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
414684009446	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
414684009447	F0F1 ATP synthase subunit C; Validated; Region: PRK07558
414684009448	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
414684009449	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
414684009450	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
414684009451	glucokinase, proteobacterial type; Region: glk; TIGR00749
414684009452	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
414684009453	nucleotide binding site [chemical binding]; other site
414684009454	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
414684009455	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
414684009456	active site
414684009457	homotetramer interface [polypeptide binding]; other site
414684009458	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
414684009459	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
414684009460	N-formylglutamate amidohydrolase; Region: FGase; cl01522
414684009461	Helix-turn-helix domain; Region: HTH_17; cl17695
414684009462	PIN domain; Region: PIN_3; pfam13470
414684009463	AMP-binding domain protein; Validated; Region: PRK07529
414684009464	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
414684009465	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
414684009466	acyl-activating enzyme (AAE) consensus motif; other site
414684009467	AMP binding site [chemical binding]; other site
414684009468	active site
414684009469	acyl-activating enzyme (AAE) consensus motif; other site
414684009470	CoA binding site [chemical binding]; other site
414684009471	enoyl-CoA hydratase; Provisional; Region: PRK06210
414684009472	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
414684009473	substrate binding site [chemical binding]; other site
414684009474	oxyanion hole (OAH) forming residues; other site
414684009475	trimer interface [polypeptide binding]; other site
414684009476	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
414684009477	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
414684009478	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
414684009479	N-terminal plug; other site
414684009480	ligand-binding site [chemical binding]; other site
414684009481	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
414684009482	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
414684009483	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
414684009484	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
414684009485	WHG domain; Region: WHG; pfam13305
414684009486	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
414684009487	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
414684009488	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
414684009489	acyl-activating enzyme (AAE) consensus motif; other site
414684009490	acyl-activating enzyme (AAE) consensus motif; other site
414684009491	putative AMP binding site [chemical binding]; other site
414684009492	putative active site [active]
414684009493	putative CoA binding site [chemical binding]; other site
414684009494	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
414684009495	active site
414684009496	catalytic site [active]
414684009497	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
414684009498	active site 1 [active]
414684009499	active site 2 [active]
414684009500	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
414684009501	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
414684009502	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
414684009503	NAD(P) binding site [chemical binding]; other site
414684009504	active site
414684009505	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
414684009506	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
414684009507	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
414684009508	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
414684009509	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
414684009510	carboxyltransferase (CT) interaction site; other site
414684009511	biotinylation site [posttranslational modification]; other site
414684009512	enoyl-CoA hydratase; Provisional; Region: PRK05995
414684009513	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
414684009514	substrate binding site [chemical binding]; other site
414684009515	oxyanion hole (OAH) forming residues; other site
414684009516	trimer interface [polypeptide binding]; other site
414684009517	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
414684009518	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
414684009519	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
414684009520	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
414684009521	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
414684009522	active site
414684009523	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
414684009524	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
414684009525	acyl-activating enzyme (AAE) consensus motif; other site
414684009526	putative AMP binding site [chemical binding]; other site
414684009527	putative active site [active]
414684009528	putative CoA binding site [chemical binding]; other site
414684009529	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
414684009530	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
414684009531	elongation factor G; Reviewed; Region: PRK00007
414684009532	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
414684009533	G1 box; other site
414684009534	putative GEF interaction site [polypeptide binding]; other site
414684009535	GTP/Mg2+ binding site [chemical binding]; other site
414684009536	Switch I region; other site
414684009537	G2 box; other site
414684009538	G3 box; other site
414684009539	Switch II region; other site
414684009540	G4 box; other site
414684009541	G5 box; other site
414684009542	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
414684009543	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
414684009544	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
414684009545	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
414684009546	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
414684009547	putative oligomer interface [polypeptide binding]; other site
414684009548	putative active site [active]
414684009549	metal binding site [ion binding]; metal-binding site
414684009550	GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT
414684009551	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
414684009552	ATP-grasp domain; Region: ATP-grasp_4; cl17255
414684009553	asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104
414684009554	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
414684009555	active site
414684009556	dimer interface [polypeptide binding]; other site
414684009557	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
414684009558	Ligand Binding Site [chemical binding]; other site
414684009559	Molecular Tunnel; other site
414684009560	ferrochelatase; Reviewed; Region: hemH; PRK00035
414684009561	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
414684009562	C-terminal domain interface [polypeptide binding]; other site
414684009563	active site
414684009564	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
414684009565	active site
414684009566	N-terminal domain interface [polypeptide binding]; other site
414684009567	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
414684009568	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
414684009569	tetramer interface [polypeptide binding]; other site
414684009570	heme binding pocket [chemical binding]; other site
414684009571	NADPH binding site [chemical binding]; other site
414684009572	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
414684009573	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
414684009574	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
414684009575	dimerization interface [polypeptide binding]; other site
414684009576	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
414684009577	active site
414684009578	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
414684009579	PrkA family serine protein kinase; Provisional; Region: PRK15455
414684009580	AAA ATPase domain; Region: AAA_16; pfam13191
414684009581	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
414684009582	hypothetical protein; Provisional; Region: PRK05325
414684009583	SpoVR family protein; Provisional; Region: PRK11767
414684009584	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
414684009585	enoyl-CoA hydratase; Provisional; Region: PRK06688
414684009586	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
414684009587	substrate binding site [chemical binding]; other site
414684009588	oxyanion hole (OAH) forming residues; other site
414684009589	trimer interface [polypeptide binding]; other site
414684009590	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
414684009591	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
414684009592	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
414684009593	Tetratricopeptide repeat; Region: TPR_12; pfam13424
414684009594	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
414684009595	TPR motif; other site
414684009596	binding surface
414684009597	Tetratricopeptide repeat; Region: TPR_12; pfam13424
414684009598	Tetratricopeptide repeat; Region: TPR_12; pfam13424
414684009599	GAF domain; Region: GAF_2; pfam13185
414684009600	GAF domain; Region: GAF_3; pfam13492
414684009601	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
414684009602	homodimer interface [polypeptide binding]; other site
414684009603	active site
414684009604	SAM binding site [chemical binding]; other site
414684009605	secreted effector protein PipB2; Provisional; Region: PRK15196
414684009606	phosphoenolpyruvate synthase; Validated; Region: PRK06464
414684009607	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
414684009608	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
414684009609	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
414684009610	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
414684009611	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
414684009612	DNA binding residues [nucleotide binding]
414684009613	chaperone protein DnaJ; Provisional; Region: PRK14299
414684009614	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
414684009615	HSP70 interaction site [polypeptide binding]; other site
414684009616	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
414684009617	substrate binding site [polypeptide binding]; other site
414684009618	dimer interface [polypeptide binding]; other site
414684009619	thioredoxin 2; Provisional; Region: PRK10996
414684009620	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
414684009621	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
414684009622	catalytic residues [active]
414684009623	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
414684009624	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
414684009625	Beta-lactamase; Region: Beta-lactamase; cl17358
414684009626	DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834
414684009627	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
414684009628	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
414684009629	dimerization interface [polypeptide binding]; other site
414684009630	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
414684009631	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684009632	dimer interface [polypeptide binding]; other site
414684009633	putative CheW interface [polypeptide binding]; other site
414684009634	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
414684009635	active site
414684009636	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
414684009637	active site
414684009638	substrate binding pocket [chemical binding]; other site
414684009639	dimer interface [polypeptide binding]; other site
414684009640	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
414684009641	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
414684009642	dimer interface [polypeptide binding]; other site
414684009643	motif 1; other site
414684009644	active site
414684009645	motif 2; other site
414684009646	motif 3; other site
414684009647	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
414684009648	anticodon binding site; other site
414684009649	glycosyl transferase, family 51, pseudogene;identified by match to protein family HMM PF00762 match to protein family HMM TIGR00109
414684009650	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
414684009651	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
414684009652	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
414684009653	dimer interaction site [polypeptide binding]; other site
414684009654	substrate-binding tunnel; other site
414684009655	active site
414684009656	catalytic site [active]
414684009657	substrate binding site [chemical binding]; other site
414684009658	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
414684009659	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
414684009660	FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196
414684009661	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
414684009662	active site
414684009663	Riboflavin kinase; Region: Flavokinase; smart00904
414684009664	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
414684009665	oligomeric interface; other site
414684009666	putative active site [active]
414684009667	homodimer interface [polypeptide binding]; other site
414684009668	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
414684009669	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
414684009670	active site
414684009671	HIGH motif; other site
414684009672	nucleotide binding site [chemical binding]; other site
414684009673	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
414684009674	active site
414684009675	KMSKS motif; other site
414684009676	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
414684009677	tRNA binding surface [nucleotide binding]; other site
414684009678	anticodon binding site; other site
414684009679	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
414684009680	lipoprotein signal peptidase; Provisional; Region: PRK14787
414684009681	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
414684009682	conserved hypothetical protein, pseudogene
414684009683	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
414684009684	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
414684009685	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
414684009686	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
414684009687	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
414684009688	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
414684009689	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
414684009690	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
414684009691	active site
414684009692	dimer interface [polypeptide binding]; other site
414684009693	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
414684009694	dimer interface [polypeptide binding]; other site
414684009695	active site
414684009696	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
414684009697	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
414684009698	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
414684009699	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
414684009700	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
414684009701	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
414684009702	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
414684009703	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
414684009704	nucleoside/Zn binding site; other site
414684009705	dimer interface [polypeptide binding]; other site
414684009706	catalytic motif [active]
414684009707	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
414684009708	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
414684009709	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
414684009710	Transposase [DNA replication, recombination, and repair]; Region: COG5433
414684009711	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
414684009712	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
414684009713	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
414684009714	RNA binding surface [nucleotide binding]; other site
414684009715	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
414684009716	active site
414684009717	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
414684009718	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684009719	S-adenosylmethionine binding site [chemical binding]; other site
414684009720	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
414684009721	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
414684009722	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684009723	ATP binding site [chemical binding]; other site
414684009724	Mg2+ binding site [ion binding]; other site
414684009725	G-X-G motif; other site
414684009726	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
414684009727	ATP binding site [chemical binding]; other site
414684009728	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
414684009729	Methyltransferase domain; Region: Methyltransf_12; pfam08242
414684009730	TPR domain protein, pseudogene;identified by match to protein family HMM PF01979 match to protein family HMM TIGR00856
414684009731	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
414684009732	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
414684009733	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
414684009734	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
414684009735	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
414684009736	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
414684009737	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
414684009738	catalytic residue [active]
414684009739	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
414684009740	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
414684009741	PhnA protein; Region: PhnA; pfam03831
414684009742	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
414684009743	non-specific DNA binding site [nucleotide binding]; other site
414684009744	salt bridge; other site
414684009745	sequence-specific DNA binding site [nucleotide binding]; other site
414684009746	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
414684009747	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
414684009748	generic binding surface II; other site
414684009749	generic binding surface I; other site
414684009750	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
414684009751	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
414684009752	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
414684009753	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
414684009754	putative acyl-acceptor binding pocket; other site
414684009755	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
414684009756	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
414684009757	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
414684009758	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
414684009759	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
414684009760	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
414684009761	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
414684009762	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
414684009763	Predicted methyltransferase [General function prediction only]; Region: COG3897
414684009764	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
414684009765	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
414684009766	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878
414684009767	UbiA prenyltransferase family; Region: UbiA; pfam01040
414684009768	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
414684009769	Major Facilitator Superfamily; Region: MFS_1; pfam07690
414684009770	RNA methyltransferase, RsmE family; Region: TIGR00046
414684009771	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
414684009772	glutamate--cysteine ligase; Region: PLN02611
414684009773	protease TldD; Provisional; Region: tldD; PRK10735
414684009774	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00154
414684009775	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
414684009776	cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007
414684009777	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
414684009778	Subunit I/III interface [polypeptide binding]; other site
414684009779	D-pathway; other site
414684009780	Subunit I/VIIc interface [polypeptide binding]; other site
414684009781	Subunit I/IV interface [polypeptide binding]; other site
414684009782	Subunit I/II interface [polypeptide binding]; other site
414684009783	Low-spin heme (heme a) binding site [chemical binding]; other site
414684009784	Subunit I/VIIa interface [polypeptide binding]; other site
414684009785	Subunit I/VIa interface [polypeptide binding]; other site
414684009786	Dimer interface; other site
414684009787	Putative water exit pathway; other site
414684009788	Binuclear center (heme a3/CuB) [ion binding]; other site
414684009789	K-pathway; other site
414684009790	Subunit I/Vb interface [polypeptide binding]; other site
414684009791	Putative proton exit pathway; other site
414684009792	Subunit I/VIb interface; other site
414684009793	Subunit I/VIc interface [polypeptide binding]; other site
414684009794	Electron transfer pathway; other site
414684009795	Subunit I/VIIIb interface [polypeptide binding]; other site
414684009796	Subunit I/VIIb interface [polypeptide binding]; other site
414684009797	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
414684009798	UbiA prenyltransferase family; Region: UbiA; pfam01040
414684009799	Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; pfam04442
414684009800	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
414684009801	Subunit III/VIIa interface [polypeptide binding]; other site
414684009802	Phospholipid binding site [chemical binding]; other site
414684009803	Subunit I/III interface [polypeptide binding]; other site
414684009804	Subunit III/VIb interface [polypeptide binding]; other site
414684009805	Subunit III/VIa interface; other site
414684009806	Subunit III/Vb interface [polypeptide binding]; other site
414684009807	Protein of unknown function (DUF983); Region: DUF983; cl02211
414684009808	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
414684009809	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
414684009810	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
414684009811	pyridoxal 5'-phosphate binding site [chemical binding]; other site
414684009812	catalytic residue [active]
414684009813	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
414684009814	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
414684009815	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
414684009816	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
414684009817	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
414684009818	hypothetical protein; Validated; Region: PRK00228
414684009819	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
414684009820	catalytic triad [active]
414684009821	dimer interface [polypeptide binding]; other site
414684009822	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
414684009823	RNA/DNA hybrid binding site [nucleotide binding]; other site
414684009824	active site
414684009825	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
414684009826	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
414684009827	putative active site [active]
414684009828	putative substrate binding site [chemical binding]; other site
414684009829	ATP binding site [chemical binding]; other site
414684009830	phage shock protein A; Region: phageshock_pspA; TIGR02977
414684009831	PspC domain; Region: PspC; cl00864
414684009832	PemK-like protein; Region: PemK; cl00995
414684009833	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
414684009834	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
414684009835	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
414684009836	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
414684009837	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
414684009838	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
414684009839	lipoyl attachment site [posttranslational modification]; other site
414684009840	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
414684009841	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
414684009842	tetramer interface [polypeptide binding]; other site
414684009843	pyridoxal 5'-phosphate binding site [chemical binding]; other site
414684009844	catalytic residue [active]
414684009845	glycine dehydrogenase subunit 2; Validated; Region: PRK04366
414684009846	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
414684009847	catalytic residue [active]
414684009848	hypothetical protein; Provisional; Region: PRK08912
414684009849	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
414684009850	pyridoxal 5'-phosphate binding site [chemical binding]; other site
414684009851	homodimer interface [polypeptide binding]; other site
414684009852	catalytic residue [active]
414684009853	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
414684009854	MG2 domain; Region: A2M_N; pfam01835
414684009855	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
414684009856	Alpha-2-macroglobulin family; Region: A2M; pfam00207
414684009857	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
414684009858	surface patch; other site
414684009859	thioester region; other site
414684009860	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
414684009861	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
414684009862	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
414684009863	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647
414684009864	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
414684009865	Domain of unknown function (DUF4040); Region: DUF4040; pfam13244
414684009866	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12509
414684009867	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12658
414684009868	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663
414684009869	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
414684009870	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651
414684009871	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599
414684009872	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
414684009873	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
414684009874	DNA-binding site [nucleotide binding]; DNA binding site
414684009875	RNA-binding motif; other site
414684009876	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
414684009877	DNA-binding site [nucleotide binding]; DNA binding site
414684009878	RNA-binding motif; other site
414684009879	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710
414684009880	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
414684009881	acyl-activating enzyme (AAE) consensus motif; other site
414684009882	putative AMP binding site [chemical binding]; other site
414684009883	putative active site [active]
414684009884	putative CoA binding site [chemical binding]; other site
414684009885	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
414684009886	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
414684009887	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
414684009888	Transposase [DNA replication, recombination, and repair]; Region: COG5433
414684009889	DDE superfamily endonuclease; Region: DDE_3; pfam13358
414684009890	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
414684009891	Winged helix-turn helix; Region: HTH_29; pfam13551
414684009892	Helix-turn-helix domain; Region: HTH_28; pfam13518
414684009893	Winged helix-turn helix; Region: HTH_33; pfam13592
414684009894	Rop-like; Region: Rop-like; pfam05082
414684009895	probable nitrogen fixation protein; Region: TIGR02935
414684009896	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
414684009897	nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478
414684009898	bifunctional nitrogenase molybdenum-cofactor biosynthesis protein NifE/NifN; Provisional; Region: PRK14477
414684009899	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
414684009900	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
414684009901	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
414684009902	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
414684009903	MoFe protein beta/alpha subunit interactions; other site
414684009904	Beta subunit P cluster binding residues; other site
414684009905	MoFe protein beta subunit/Fe protein contacts; other site
414684009906	MoFe protein dimer/ dimer interactions; other site
414684009907	Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
414684009908	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
414684009909	MoFe protein alpha/beta subunit interactions; other site
414684009910	Alpha subunit P cluster binding residues; other site
414684009911	FeMoco binding residues [chemical binding]; other site
414684009912	MoFe protein alpha subunit/Fe protein contacts; other site
414684009913	MoFe protein dimer/ dimer interactions; other site
414684009914	nitrogenase reductase; Reviewed; Region: nifH; PRK13234
414684009915	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
414684009916	Nucleotide-binding sites [chemical binding]; other site
414684009917	Walker A motif; other site
414684009918	Switch I region of nucleotide binding site; other site
414684009919	Fe4S4 binding sites [ion binding]; other site
414684009920	Switch II region of nucleotide binding site; other site
414684009921	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
414684009922	TOBE domain; Region: TOBE; cl01440
414684009923	SIR2-like domain; Region: SIR2_2; pfam13289
414684009924	NifT/FixU protein; Region: NifT; pfam06988
414684009925	NifZ domain; Region: NifZ; pfam04319
414684009926	archaeoflavoprotein, MJ0208 family; Region: flavo_MJ0208; TIGR02700
414684009927	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
414684009928	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
414684009929	FeS/SAM binding site; other site
414684009930	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
414684009931	Nif-specific regulatory protein; Region: nifA; TIGR01817
414684009932	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
414684009933	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
414684009934	Walker A motif; other site
414684009935	ATP binding site [chemical binding]; other site
414684009936	Walker B motif; other site
414684009937	arginine finger; other site
414684009938	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
414684009939	homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660
414684009940	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
414684009941	active site
414684009942	catalytic residues [active]
414684009943	metal binding site [ion binding]; metal-binding site
414684009944	Nitrogen fixation protein NifW; Region: NifW; cl03935
414684009945	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
414684009946	Ligand binding site [chemical binding]; other site
414684009947	Electron transfer flavoprotein domain; Region: ETF; pfam01012
414684009948	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
414684009949	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
414684009950	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
414684009951	oxidoreductase; Provisional; Region: PRK10015
414684009952	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
414684009953	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
414684009954	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
414684009955	ArsC family; Region: ArsC; pfam03960
414684009956	catalytic residues [active]
414684009957	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
414684009958	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
414684009959	AAA ATPase domain; Region: AAA_16; pfam13191
414684009960	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
414684009961	DNA binding residues [nucleotide binding]
414684009962	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
414684009963	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
414684009964	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
414684009965	Protein of unknown function (DUF917); Region: DUF917; pfam06032
414684009966	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
414684009967	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
414684009968	N-terminal plug; other site
414684009969	ligand-binding site [chemical binding]; other site
414684009970	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
414684009971	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
414684009972	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
414684009973	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
414684009974	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
414684009975	Cupin domain; Region: Cupin_2; cl17218
414684009976	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
414684009977	hydroxyglutarate oxidase; Provisional; Region: PRK11728
414684009978	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
414684009979	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
414684009980	active site
414684009981	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
414684009982	putative FMN binding site [chemical binding]; other site
414684009983	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
414684009984	oligomeric interface; other site
414684009985	putative active site [active]
414684009986	homodimer interface [polypeptide binding]; other site
414684009987	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
414684009988	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
414684009989	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
414684009990	active site
414684009991	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
414684009992	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
414684009993	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
414684009994	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
414684009995	PAS domain; Region: PAS_9; pfam13426
414684009996	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684009997	putative active site [active]
414684009998	heme pocket [chemical binding]; other site
414684009999	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
414684010000	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684010001	dimer interface [polypeptide binding]; other site
414684010002	phosphorylation site [posttranslational modification]
414684010003	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684010004	ATP binding site [chemical binding]; other site
414684010005	Mg2+ binding site [ion binding]; other site
414684010006	G-X-G motif; other site
414684010007	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
414684010008	HlyD family secretion protein; Region: HlyD_3; pfam13437
414684010009	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
414684010010	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
414684010011	Walker A/P-loop; other site
414684010012	ATP binding site [chemical binding]; other site
414684010013	Q-loop/lid; other site
414684010014	ABC transporter signature motif; other site
414684010015	Walker B; other site
414684010016	D-loop; other site
414684010017	H-loop/switch region; other site
414684010018	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
414684010019	Walker A/P-loop; other site
414684010020	ATP binding site [chemical binding]; other site
414684010021	Q-loop/lid; other site
414684010022	ABC transporter signature motif; other site
414684010023	Walker B; other site
414684010024	D-loop; other site
414684010025	H-loop/switch region; other site
414684010026	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
414684010027	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
414684010028	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
414684010029	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
414684010030	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
414684010031	non-specific DNA binding site [nucleotide binding]; other site
414684010032	salt bridge; other site
414684010033	sequence-specific DNA binding site [nucleotide binding]; other site
414684010034	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
414684010035	dimer interface [polypeptide binding]; other site
414684010036	conserved gate region; other site
414684010037	putative PBP binding loops; other site
414684010038	ABC-ATPase subunit interface; other site
414684010039	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
414684010040	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
414684010041	dimer interface [polypeptide binding]; other site
414684010042	conserved gate region; other site
414684010043	putative PBP binding loops; other site
414684010044	ABC-ATPase subunit interface; other site
414684010045	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
414684010046	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
414684010047	Walker A/P-loop; other site
414684010048	ATP binding site [chemical binding]; other site
414684010049	Q-loop/lid; other site
414684010050	ABC transporter signature motif; other site
414684010051	Walker B; other site
414684010052	D-loop; other site
414684010053	H-loop/switch region; other site
414684010054	TOBE domain; Region: TOBE_2; pfam08402
414684010055	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
414684010056	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
414684010057	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
414684010058	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
414684010059	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
414684010060	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
414684010061	homodimer interaction site [polypeptide binding]; other site
414684010062	cofactor binding site; other site
414684010063	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
414684010064	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
414684010065	N-terminal plug; other site
414684010066	ligand-binding site [chemical binding]; other site
414684010067	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
414684010068	Metal binding protein HemV-2.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147
414684010069	putative metal binding site [ion binding]; other site
414684010070	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
414684010071	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
414684010072	ABC-ATPase subunit  interface; other site
414684010073	dimer interface [polypeptide binding]; other site
414684010074	putative PBP binding regions; other site
414684010075	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
414684010076	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
414684010077	Walker A/P-loop; other site
414684010078	ATP binding site [chemical binding]; other site
414684010079	Q-loop/lid; other site
414684010080	ABC transporter signature motif; other site
414684010081	Walker B; other site
414684010082	D-loop; other site
414684010083	H-loop/switch region; other site
414684010084	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
414684010085	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
414684010086	P-loop; other site
414684010087	Magnesium ion binding site [ion binding]; other site
414684010088	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
414684010089	Magnesium ion binding site [ion binding]; other site
414684010090	ParB-like nuclease domain; Region: ParB; smart00470
414684010091	Predicted membrane protein [Function unknown]; Region: COG2364
414684010092	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
414684010093	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
414684010094	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
414684010095	dimerization interface [polypeptide binding]; other site
414684010096	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684010097	dimer interface [polypeptide binding]; other site
414684010098	phosphorylation site [posttranslational modification]
414684010099	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684010100	ATP binding site [chemical binding]; other site
414684010101	Mg2+ binding site [ion binding]; other site
414684010102	G-X-G motif; other site
414684010103	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
414684010104	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684010105	active site
414684010106	phosphorylation site [posttranslational modification]
414684010107	intermolecular recognition site; other site
414684010108	dimerization interface [polypeptide binding]; other site
414684010109	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
414684010110	DNA binding site [nucleotide binding]
414684010111	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
414684010112	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
414684010113	HlyD family secretion protein; Region: HlyD_3; pfam13437
414684010114	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
414684010115	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
414684010116	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
414684010117	putative ADP-binding pocket [chemical binding]; other site
414684010118	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
414684010119	HD domain; Region: HD_3; cl17350
414684010120	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
414684010121	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
414684010122	flagellar basal-body rod protein FlgC; Region: FlgC; TIGR01395
414684010123	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
414684010124	Flagellar protein FlbT; Region: FlbT; cl11455
414684010125	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521
414684010126	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
414684010127	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
414684010128	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
414684010129	Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344
414684010130	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
414684010131	Flagellar protein FlaF; Region: FlaF; pfam07309
414684010132	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
414684010133	Protein of unknown function DUF115; Region: MAF_flag10; pfam01973
414684010134	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
414684010135	NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078
414684010136	NAD(P) binding site [chemical binding]; other site
414684010137	catalytic residues [active]
414684010138	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
414684010139	ligand binding site; other site
414684010140	tetramer interface; other site
414684010141	transketolase; Reviewed; Region: PRK05899
414684010142	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
414684010143	TPP-binding site [chemical binding]; other site
414684010144	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
414684010145	PYR/PP interface [polypeptide binding]; other site
414684010146	dimer interface [polypeptide binding]; other site
414684010147	TPP binding site [chemical binding]; other site
414684010148	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
414684010149	short chain dehydrogenase; Provisional; Region: PRK06841
414684010150	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
414684010151	NAD(P) binding site [chemical binding]; other site
414684010152	active site
414684010153	Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089
414684010154	NeuB family; Region: NeuB; pfam03102
414684010155	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
414684010156	NeuB binding interface [polypeptide binding]; other site
414684010157	putative substrate binding site [chemical binding]; other site
414684010158	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
414684010159	active site
414684010160	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
414684010161	extended (e) SDRs; Region: SDR_e; cd08946
414684010162	NAD(P) binding site [chemical binding]; other site
414684010163	active site
414684010164	substrate binding site [chemical binding]; other site
414684010165	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
414684010166	Cephalosporin hydroxylase; Region: CmcI; pfam04989
414684010167	Methyltransferase domain; Region: Methyltransf_23; pfam13489
414684010168	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
414684010169	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
414684010170	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
414684010171	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
414684010172	Methyltransferase domain; Region: Methyltransf_23; pfam13489
414684010173	Methyltransferase domain; Region: Methyltransf_12; pfam08242
414684010174	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
414684010175	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
414684010176	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
414684010177	NAD(P) binding site [chemical binding]; other site
414684010178	active site
414684010179	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
414684010180	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
414684010181	substrate binding site; other site
414684010182	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
414684010183	active site
414684010184	dimer interface [polypeptide binding]; other site
414684010185	Glutamine amidotransferase domain; Region: GATase_6; pfam13522
414684010186	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
414684010187	Ligand Binding Site [chemical binding]; other site
414684010188	Molecular Tunnel; other site
414684010189	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
414684010190	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
414684010191	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
414684010192	cyclase homology domain; Region: CHD; cd07302
414684010193	nucleotidyl binding site; other site
414684010194	metal binding site [ion binding]; metal-binding site
414684010195	dimer interface [polypeptide binding]; other site
414684010196	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
414684010197	Uncharacterized conserved protein [Function unknown]; Region: COG1944
414684010198	YcaO-like family; Region: YcaO; pfam02624
414684010199	Uncharacterized conserved protein [Function unknown]; Region: COG3482
414684010200	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
414684010201	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
414684010202	ligand binding site [chemical binding]; other site
414684010203	flexible hinge region; other site
414684010204	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
414684010205	putative switch regulator; other site
414684010206	non-specific DNA interactions [nucleotide binding]; other site
414684010207	DNA binding site [nucleotide binding]
414684010208	sequence specific DNA binding site [nucleotide binding]; other site
414684010209	putative cAMP binding site [chemical binding]; other site
414684010210	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
414684010211	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
414684010212	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
414684010213	Walker A/P-loop; other site
414684010214	ATP binding site [chemical binding]; other site
414684010215	Q-loop/lid; other site
414684010216	ABC transporter signature motif; other site
414684010217	Walker B; other site
414684010218	D-loop; other site
414684010219	H-loop/switch region; other site
414684010220	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
414684010221	KpsF/GutQ family protein; Region: kpsF; TIGR00393
414684010222	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
414684010223	putative active site [active]
414684010224	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
414684010225	Transmembrane secretion effector; Region: MFS_3; pfam05977
414684010226	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
414684010227	putative substrate translocation pore; other site
414684010228	Protein of unknown function (DUF3445); Region: DUF3445; pfam11927
414684010229	Replication initiator protein A; Region: RPA; pfam10134
414684010230	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
414684010231	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
414684010232	NAD binding site [chemical binding]; other site
414684010233	putative substrate binding site 2 [chemical binding]; other site
414684010234	putative substrate binding site 1 [chemical binding]; other site
414684010235	active site
414684010236	PAS fold; Region: PAS_2; pfam08446
414684010237	GAF domain; Region: GAF; pfam01590
414684010238	Phytochrome region; Region: PHY; pfam00360
414684010239	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
414684010240	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684010241	dimer interface [polypeptide binding]; other site
414684010242	phosphorylation site [posttranslational modification]
414684010243	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684010244	ATP binding site [chemical binding]; other site
414684010245	Mg2+ binding site [ion binding]; other site
414684010246	G-X-G motif; other site
414684010247	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
414684010248	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
414684010249	tetramer interface [polypeptide binding]; other site
414684010250	active site
414684010251	Mg2+/Mn2+ binding site [ion binding]; other site
414684010252	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
414684010253	methylcitrate synthase; Provisional; Region: PRK12351
414684010254	oxalacetate binding site [chemical binding]; other site
414684010255	citrylCoA binding site [chemical binding]; other site
414684010256	coenzyme A binding site [chemical binding]; other site
414684010257	catalytic triad [active]
414684010258	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
414684010259	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
414684010260	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
414684010261	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
414684010262	sequence-specific DNA binding site [nucleotide binding]; other site
414684010263	salt bridge; other site
414684010264	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
414684010265	Domain of unknown function (DUF955); Region: DUF955; pfam06114
414684010266	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
414684010267	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
414684010268	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
414684010269	Secretin and TonB N terminus short domain; Region: STN; smart00965
414684010270	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
414684010271	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
414684010272	N-terminal plug; other site
414684010273	ligand-binding site [chemical binding]; other site
414684010274	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
414684010275	FecR protein; Region: FecR; pfam04773
414684010276	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
414684010277	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
414684010278	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
414684010279	DNA binding residues [nucleotide binding]
414684010280	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
414684010281	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
414684010282	Beta-Casp domain; Region: Beta-Casp; smart01027
414684010283	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
414684010284	RES domain; Region: RES; smart00953
414684010285	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
414684010286	sequence-specific DNA binding site [nucleotide binding]; other site
414684010287	salt bridge; other site
414684010288	Protein of unknown function (DUF2384); Region: DUF2384; cl17718
414684010289	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
414684010290	active site
414684010291	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
414684010292	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
414684010293	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
414684010294	HlyD family secretion protein; Region: HlyD_3; pfam13437
414684010295	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
414684010296	HlyD family secretion protein; Region: HlyD_3; pfam13437
414684010297	Outer membrane efflux protein; Region: OEP; pfam02321
414684010298	Outer membrane efflux protein; Region: OEP; pfam02321
414684010299	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
414684010300	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
414684010301	VCBS repeat; Region: VCBS_repeat; TIGR01965
414684010302	Cadherin repeat-like domain; Region: CA_like; cl15786
414684010303	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
414684010304	Ca2+ binding site [ion binding]; other site
414684010305	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
414684010306	Cadherin repeat-like domain; Region: CA_like; cl15786
414684010307	Ca2+ binding site [ion binding]; other site
414684010308	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
414684010309	Cadherin repeat-like domain; Region: CA_like; cl15786
414684010310	Ca2+ binding site [ion binding]; other site
414684010311	Cadherin repeat-like domain; Region: CA_like; cl15786
414684010312	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
414684010313	Ca2+ binding site [ion binding]; other site
414684010314	Cadherin repeat-like domain; Region: CA_like; cl15786
414684010315	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
414684010316	Ca2+ binding site [ion binding]; other site
414684010317	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
414684010318	PAS domain; Region: PAS_5; pfam07310
414684010319	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
414684010320	heme-binding site [chemical binding]; other site
414684010321	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684010322	dimer interface [polypeptide binding]; other site
414684010323	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
414684010324	putative CheW interface [polypeptide binding]; other site
414684010325	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
414684010326	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
414684010327	Domain of unknown function DUF87; Region: DUF87; pfam01935
414684010328	AAA-like domain; Region: AAA_10; pfam12846
414684010329	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
414684010330	active site clefts [active]
414684010331	zinc binding site [ion binding]; other site
414684010332	dimer interface [polypeptide binding]; other site
414684010333	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
414684010334	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
414684010335	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
414684010336	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684010337	dimer interface [polypeptide binding]; other site
414684010338	putative CheW interface [polypeptide binding]; other site
414684010339	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
414684010340	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
414684010341	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
414684010342	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
414684010343	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
414684010344	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
414684010345	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
414684010346	Walker A/P-loop; other site
414684010347	ATP binding site [chemical binding]; other site
414684010348	Q-loop/lid; other site
414684010349	ABC transporter signature motif; other site
414684010350	Walker B; other site
414684010351	D-loop; other site
414684010352	H-loop/switch region; other site
414684010353	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
414684010354	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
414684010355	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
414684010356	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
414684010357	coproporphyrinogen III oxidase; Provisional; Region: PRK09058
414684010358	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
414684010359	FeS/SAM binding site; other site
414684010360	putative heme utilization carrier protein HutX; Region: HutX; TIGR04108
414684010361	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
414684010362	FecR protein; Region: FecR; pfam04773
414684010363	Domain of unknown function DUF87; Region: DUF87; pfam01935
414684010364	HerA helicase [Replication, recombination, and repair]; Region: COG0433
414684010365	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
414684010366	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
414684010367	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
414684010368	DNA binding residues [nucleotide binding]
414684010369	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
414684010370	TPR motif; other site
414684010371	binding surface
414684010372	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
414684010373	binding surface
414684010374	TPR motif; other site
414684010375	Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; cl17879
414684010376	bacterial Hfq-like; Region: Hfq; cd01716
414684010377	hexamer interface [polypeptide binding]; other site
414684010378	Sm1 motif; other site
414684010379	RNA binding site [nucleotide binding]; other site
414684010380	Sm2 motif; other site
414684010381	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
414684010382	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
414684010383	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
414684010384	ligand binding site [chemical binding]; other site
414684010385	flexible hinge region; other site
414684010386	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
414684010387	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
414684010388	active site residue [active]
414684010389	OsmC-like protein; Region: OsmC; pfam02566
414684010390	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323
414684010391	gating phenylalanine in ion channel; other site
414684010392	Creatinine amidohydrolase; Region: Creatininase; pfam02633
414684010393	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
414684010394	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
414684010395	N-terminal plug; other site
414684010396	ligand-binding site [chemical binding]; other site
414684010397	Hemin uptake protein hemP; Region: hemP; pfam10636
414684010398	Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720
414684010399	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
414684010400	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
414684010401	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
414684010402	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
414684010403	intersubunit interface [polypeptide binding]; other site
414684010404	FecCD transport family; Region: FecCD; pfam01032
414684010405	putative PBP binding regions; other site
414684010406	ABC-ATPase subunit  interface; other site
414684010407	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
414684010408	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
414684010409	Walker A/P-loop; other site
414684010410	ATP binding site [chemical binding]; other site
414684010411	Q-loop/lid; other site
414684010412	ABC transporter signature motif; other site
414684010413	Walker B; other site
414684010414	D-loop; other site
414684010415	H-loop/switch region; other site
414684010416	Rrf2 family protein; Region: rrf2_super; TIGR00738
414684010417	Transcriptional regulator; Region: Rrf2; pfam02082
414684010418	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684010419	PAS domain; Region: PAS_9; pfam13426
414684010420	putative active site [active]
414684010421	heme pocket [chemical binding]; other site
414684010422	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
414684010423	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684010424	dimer interface [polypeptide binding]; other site
414684010425	putative CheW interface [polypeptide binding]; other site
414684010426	PilZ domain; Region: PilZ; pfam07238
414684010427	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
414684010428	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
414684010429	substrate binding pocket [chemical binding]; other site
414684010430	membrane-bound complex binding site; other site
414684010431	hinge residues; other site
414684010432	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
414684010433	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
414684010434	dimer interface [polypeptide binding]; other site
414684010435	conserved gate region; other site
414684010436	putative PBP binding loops; other site
414684010437	ABC-ATPase subunit interface; other site
414684010438	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
414684010439	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
414684010440	dimer interface [polypeptide binding]; other site
414684010441	conserved gate region; other site
414684010442	putative PBP binding loops; other site
414684010443	ABC-ATPase subunit interface; other site
414684010444	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
414684010445	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
414684010446	Walker A/P-loop; other site
414684010447	ATP binding site [chemical binding]; other site
414684010448	Q-loop/lid; other site
414684010449	ABC transporter signature motif; other site
414684010450	Walker B; other site
414684010451	D-loop; other site
414684010452	H-loop/switch region; other site
414684010453	TOBE domain; Region: TOBE_2; pfam08402
414684010454	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
414684010455	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
414684010456	N-terminal plug; other site
414684010457	ligand-binding site [chemical binding]; other site
414684010458	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cd00636
414684010459	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
414684010460	intersubunit interface [polypeptide binding]; other site
414684010461	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
414684010462	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
414684010463	dimer interface [polypeptide binding]; other site
414684010464	putative PBP binding regions; other site
414684010465	ABC-ATPase subunit  interface; other site
414684010466	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
414684010467	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
414684010468	Walker A/P-loop; other site
414684010469	ATP binding site [chemical binding]; other site
414684010470	Q-loop/lid; other site
414684010471	ABC transporter signature motif; other site
414684010472	Walker B; other site
414684010473	D-loop; other site
414684010474	H-loop/switch region; other site
414684010475	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
414684010476	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
414684010477	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
414684010478	catalytic residue [active]
414684010479	PAS fold; Region: PAS_3; pfam08447
414684010480	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
414684010481	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
414684010482	metal binding site [ion binding]; metal-binding site
414684010483	active site
414684010484	I-site; other site
414684010485	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
414684010486	CheB methylesterase; Region: CheB_methylest; pfam01339
414684010487	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
414684010488	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
414684010489	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
414684010490	PAS domain; Region: PAS_10; pfam13596
414684010491	PAS fold; Region: PAS; pfam00989
414684010492	Palmitoyl protein thioesterase; Region: Palm_thioest; cl15849
414684010493	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
414684010494	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
414684010495	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
414684010496	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
414684010497	metal binding site [ion binding]; metal-binding site
414684010498	active site
414684010499	I-site; other site
414684010500	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
414684010501	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
414684010502	putative Zn2+ binding site [ion binding]; other site
414684010503	putative DNA binding site [nucleotide binding]; other site
414684010504	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
414684010505	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
414684010506	HlyD family secretion protein; Region: HlyD_3; pfam13437
414684010507	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
414684010508	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
414684010509	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
414684010510	Trp docking motif [polypeptide binding]; other site
414684010511	putative active site [active]
414684010512	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684010513	PAS domain; Region: PAS_9; pfam13426
414684010514	putative active site [active]
414684010515	heme pocket [chemical binding]; other site
414684010516	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
414684010517	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684010518	dimer interface [polypeptide binding]; other site
414684010519	putative CheW interface [polypeptide binding]; other site
414684010520	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684010521	PAS domain; Region: PAS_9; pfam13426
414684010522	putative active site [active]
414684010523	heme pocket [chemical binding]; other site
414684010524	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
414684010525	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
414684010526	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684010527	dimer interface [polypeptide binding]; other site
414684010528	putative CheW interface [polypeptide binding]; other site
414684010529	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
414684010530	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
414684010531	N-terminal plug; other site
414684010532	ligand-binding site [chemical binding]; other site
414684010533	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
414684010534	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
414684010535	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
414684010536	Putative serine esterase (DUF676); Region: DUF676; pfam05057
414684010537	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
414684010538	Protein export membrane protein; Region: SecD_SecF; cl14618
414684010539	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
414684010540	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
414684010541	HlyD family secretion protein; Region: HlyD_3; pfam13437
414684010542	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
414684010543	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
414684010544	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
414684010545	Heavy-metal resistance; Region: Metal_resist; pfam13801
414684010546	dimer interface [polypeptide binding]; other site
414684010547	RNA polymerase sigma factor; Reviewed; Region: PRK05602
414684010548	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
414684010549	conserved hypothetical protein, pseudogene;identified by match to protein family HMM PF01032
414684010550	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
414684010551	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
414684010552	ApbE family; Region: ApbE; pfam02424
414684010553	NosL; Region: NosL; pfam05573
414684010554	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
414684010555	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
414684010556	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
414684010557	Walker A/P-loop; other site
414684010558	ATP binding site [chemical binding]; other site
414684010559	Q-loop/lid; other site
414684010560	ABC transporter signature motif; other site
414684010561	Walker B; other site
414684010562	D-loop; other site
414684010563	H-loop/switch region; other site
414684010564	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
414684010565	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
414684010566	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
414684010567	nitrous-oxide reductase; Validated; Region: PRK02888
414684010568	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
414684010569	Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901
414684010570	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
414684010571	4Fe-4S binding domain; Region: Fer4_5; pfam12801
414684010572	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684010573	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
414684010574	putative active site [active]
414684010575	heme pocket [chemical binding]; other site
414684010576	PAS fold; Region: PAS_3; pfam08447
414684010577	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
414684010578	heme pocket [chemical binding]; other site
414684010579	putative active site [active]
414684010580	PAS fold; Region: PAS_4; pfam08448
414684010581	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684010582	putative active site [active]
414684010583	heme pocket [chemical binding]; other site
414684010584	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
414684010585	HWE histidine kinase; Region: HWE_HK; smart00911
414684010586	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
414684010587	VacJ like lipoprotein; Region: VacJ; cl01073
414684010588	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151
414684010589	homotrimer interaction site [polypeptide binding]; other site
414684010590	putative active site [active]
414684010591	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
414684010592	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
414684010593	N-terminal plug; other site
414684010594	ligand-binding site [chemical binding]; other site
414684010595	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
414684010596	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
414684010597	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
414684010598	ABC transporter signature motif; other site
414684010599	Walker B; other site
414684010600	D-loop; other site
414684010601	H-loop/switch region; other site
414684010602	hydroxyglutarate oxidase; Provisional; Region: PRK11728
414684010603	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
414684010604	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
414684010605	PAS domain S-box; Region: sensory_box; TIGR00229
414684010606	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684010607	putative active site [active]
414684010608	heme pocket [chemical binding]; other site
414684010609	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684010610	PAS domain; Region: PAS_9; pfam13426
414684010611	putative active site [active]
414684010612	heme pocket [chemical binding]; other site
414684010613	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
414684010614	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
414684010615	metal binding site [ion binding]; metal-binding site
414684010616	active site
414684010617	I-site; other site
414684010618	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
414684010619	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
414684010620	Family of unknown function (DUF490); Region: DUF490; pfam04357
414684010621	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
414684010622	Surface antigen; Region: Bac_surface_Ag; pfam01103
414684010623	AMP nucleosidase; Provisional; Region: PRK08292
414684010624	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
414684010625	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
414684010626	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
414684010627	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
414684010628	pyridoxamine kinase; Validated; Region: PRK05756
414684010629	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
414684010630	dimer interface [polypeptide binding]; other site
414684010631	pyridoxal binding site [chemical binding]; other site
414684010632	ATP binding site [chemical binding]; other site
414684010633	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
414684010634	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
414684010635	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
414684010636	Protein of unknown function (DUF962); Region: DUF962; pfam06127
414684010637	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
414684010638	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
414684010639	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
414684010640	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
414684010641	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
414684010642	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
414684010643	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
414684010644	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
414684010645	N-terminal plug; other site
414684010646	ligand-binding site [chemical binding]; other site
414684010647	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
414684010648	Iron-sulfur protein interface; other site
414684010649	proximal quinone binding site [chemical binding]; other site
414684010650	SdhD (CybS) interface [polypeptide binding]; other site
414684010651	proximal heme binding site [chemical binding]; other site
414684010652	Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881
414684010653	proximal heme binding site [chemical binding]; other site
414684010654	Iron-sulfur protein interface; other site
414684010655	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
414684010656	L-aspartate oxidase; Provisional; Region: PRK06175
414684010657	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
414684010658	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
414684010659	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
414684010660	11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332
414684010661	short chain dehydrogenase; Provisional; Region: PRK06181
414684010662	NADP binding site [chemical binding]; other site
414684010663	homodimer interface [polypeptide binding]; other site
414684010664	substrate binding site [chemical binding]; other site
414684010665	active site
414684010666	intracellular septation protein A; Reviewed; Region: PRK00259
414684010667	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
414684010668	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
414684010669	G1 box; other site
414684010670	putative GEF interaction site [polypeptide binding]; other site
414684010671	GTP/Mg2+ binding site [chemical binding]; other site
414684010672	Switch I region; other site
414684010673	G2 box; other site
414684010674	G3 box; other site
414684010675	Switch II region; other site
414684010676	G4 box; other site
414684010677	G5 box; other site
414684010678	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
414684010679	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
414684010680	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
414684010681	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684010682	ATP binding site [chemical binding]; other site
414684010683	Mg2+ binding site [ion binding]; other site
414684010684	G-X-G motif; other site
414684010685	putative acyltransferase; Provisional; Region: PRK05790
414684010686	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
414684010687	dimer interface [polypeptide binding]; other site
414684010688	active site
414684010689	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
414684010690	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
414684010691	NAD(P) binding site [chemical binding]; other site
414684010692	homotetramer interface [polypeptide binding]; other site
414684010693	homodimer interface [polypeptide binding]; other site
414684010694	active site
414684010695	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673
414684010696	nudix motif; other site
414684010697	EamA-like transporter family; Region: EamA; pfam00892
414684010698	Methyltransferase domain; Region: Methyltransf_23; pfam13489
414684010699	Methyltransferase domain; Region: Methyltransf_11; pfam08241
414684010700	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
414684010701	Radical SAM superfamily; Region: Radical_SAM; pfam04055
414684010702	FeS/SAM binding site; other site
414684010703	Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746
414684010704	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
414684010705	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
414684010706	Fe-S cluster binding site [ion binding]; other site
414684010707	active site
414684010708	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
414684010709	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
414684010710	NAD(P) binding site [chemical binding]; other site
414684010711	active site
414684010712	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
414684010713	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
414684010714	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
414684010715	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
414684010716	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
414684010717	substrate binding site [chemical binding]; other site
414684010718	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
414684010719	tartrate dehydrogenase; Region: TTC; TIGR02089
414684010720	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
414684010721	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
414684010722	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
414684010723	catalytic core [active]
414684010724	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
414684010725	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
414684010726	substrate binding pocket [chemical binding]; other site
414684010727	membrane-bound complex binding site; other site
414684010728	hinge residues; other site
414684010729	Predicted ATPase [General function prediction only]; Region: COG1485
414684010730	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
414684010731	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
414684010732	Coenzyme A binding pocket [chemical binding]; other site
414684010733	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
414684010734	ThiC-associated domain; Region: ThiC-associated; pfam13667
414684010735	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
414684010736	Protein of unknown function (DUF2987); Region: DUF2987; pfam11205
414684010737	GMP synthase; Reviewed; Region: guaA; PRK00074
414684010738	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
414684010739	AMP/PPi binding site [chemical binding]; other site
414684010740	candidate oxyanion hole; other site
414684010741	catalytic triad [active]
414684010742	potential glutamine specificity residues [chemical binding]; other site
414684010743	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
414684010744	ATP Binding subdomain [chemical binding]; other site
414684010745	Ligand Binding sites [chemical binding]; other site
414684010746	Dimerization subdomain; other site
414684010747	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
414684010748	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
414684010749	short chain dehydrogenase; Provisional; Region: PRK07478
414684010750	classical (c) SDRs; Region: SDR_c; cd05233
414684010751	NAD(P) binding site [chemical binding]; other site
414684010752	active site
414684010753	Hemerythrin-like domain; Region: Hr-like; cd12108
414684010754	Fe binding site [ion binding]; other site
414684010755	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
414684010756	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
414684010757	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
414684010758	ligand binding site [chemical binding]; other site
414684010759	flexible hinge region; other site
414684010760	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
414684010761	putative switch regulator; other site
414684010762	non-specific DNA interactions [nucleotide binding]; other site
414684010763	DNA binding site [nucleotide binding]
414684010764	sequence specific DNA binding site [nucleotide binding]; other site
414684010765	putative cAMP binding site [chemical binding]; other site
414684010766	NnrS protein; Region: NnrS; pfam05940
414684010767	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
414684010768	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
414684010769	N-terminal plug; other site
414684010770	ligand-binding site [chemical binding]; other site
414684010771	Cytochrome c; Region: Cytochrom_C; cl11414
414684010772	Predicted dehydrogenase [General function prediction only]; Region: COG0579
414684010773	hydroxyglutarate oxidase; Provisional; Region: PRK11728
414684010774	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
414684010775	Methyltransferase domain; Region: Methyltransf_23; pfam13489
414684010776	Methyltransferase domain; Region: Methyltransf_12; pfam08242
414684010777	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
414684010778	short chain dehydrogenase; Provisional; Region: PRK08219
414684010779	classical (c) SDRs; Region: SDR_c; cd05233
414684010780	NAD(P) binding site [chemical binding]; other site
414684010781	active site
414684010782	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
414684010783	Domain of unknown function (DUF2172); Region: DUF2172; pfam09940
414684010784	metal binding site [ion binding]; metal-binding site
414684010785	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
414684010786	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
414684010787	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
414684010788	substrate binding site; other site
414684010789	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
414684010790	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
414684010791	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
414684010792	NAD(P) binding site [chemical binding]; other site
414684010793	active site
414684010794	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
414684010795	extended (e) SDRs; Region: SDR_e; cd08946
414684010796	NAD(P) binding site [chemical binding]; other site
414684010797	active site
414684010798	substrate binding site [chemical binding]; other site
414684010799	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
414684010800	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
414684010801	active site
414684010802	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
414684010803	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
414684010804	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
414684010805	substrate binding site; other site
414684010806	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
414684010807	Methyltransferase domain; Region: Methyltransf_23; pfam13489
414684010808	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
414684010809	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
414684010810	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
414684010811	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684010812	ATP binding site [chemical binding]; other site
414684010813	Mg2+ binding site [ion binding]; other site
414684010814	G-X-G motif; other site
414684010815	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
414684010816	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
414684010817	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
414684010818	active site
414684010819	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
414684010820	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
414684010821	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
414684010822	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
414684010823	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
414684010824	Ca2+ binding site [ion binding]; other site
414684010825	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
414684010826	Bacterial sugar transferase; Region: Bac_transf; pfam02397
414684010827	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
414684010828	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
414684010829	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
414684010830	SLBB domain; Region: SLBB; pfam10531
414684010831	Chain length determinant protein; Region: Wzz; cl15801
414684010832	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
414684010833	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
414684010834	ParA/MinD ATPase like; Region: ParA; pfam10609
414684010835	putative glycosyl transferase; Provisional; Region: PRK10307
414684010836	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
414684010837	Methyltransferase domain; Region: Methyltransf_23; pfam13489
414684010838	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684010839	S-adenosylmethionine binding site [chemical binding]; other site
414684010840	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
414684010841	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
414684010842	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
414684010843	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
414684010844	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
414684010845	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
414684010846	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
414684010847	putative metal binding site; other site
414684010848	Methyltransferase domain; Region: Methyltransf_23; pfam13489
414684010849	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684010850	S-adenosylmethionine binding site [chemical binding]; other site
414684010851	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
414684010852	TIGR01777 family protein; Region: yfcH
414684010853	NAD(P) binding site [chemical binding]; other site
414684010854	active site
414684010855	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
414684010856	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
414684010857	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
414684010858	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
414684010859	active site
414684010860	Glycosyltransferase family 17; Region: Glyco_transf_17; pfam04724
414684010861	Methyltransferase domain; Region: Methyltransf_23; pfam13489
414684010862	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684010863	S-adenosylmethionine binding site [chemical binding]; other site
414684010864	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684010865	S-adenosylmethionine binding site [chemical binding]; other site
414684010866	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
414684010867	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
414684010868	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
414684010869	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
414684010870	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
414684010871	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
414684010872	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
414684010873	active site
414684010874	dimer interface [polypeptide binding]; other site
414684010875	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
414684010876	Ligand Binding Site [chemical binding]; other site
414684010877	Molecular Tunnel; other site
414684010878	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
414684010879	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
414684010880	NAD binding site [chemical binding]; other site
414684010881	putative substrate binding site 2 [chemical binding]; other site
414684010882	putative substrate binding site 1 [chemical binding]; other site
414684010883	active site
414684010884	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
414684010885	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
414684010886	NADP-binding site; other site
414684010887	homotetramer interface [polypeptide binding]; other site
414684010888	substrate binding site [chemical binding]; other site
414684010889	homodimer interface [polypeptide binding]; other site
414684010890	active site
414684010891	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
414684010892	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
414684010893	NADP binding site [chemical binding]; other site
414684010894	active site
414684010895	putative substrate binding site [chemical binding]; other site
414684010896	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
414684010897	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
414684010898	NAD(P) binding site [chemical binding]; other site
414684010899	active site
414684010900	Cupin domain; Region: Cupin_2; cl17218
414684010901	Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039
414684010902	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
414684010903	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
414684010904	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
414684010905	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
414684010906	ABC transporter ATP-binding protein CydD, pseudogene;identified by match to protein family HMM PF02706
414684010907	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
414684010908	Walker A/P-loop; other site
414684010909	ATP binding site [chemical binding]; other site
414684010910	Q-loop/lid; other site
414684010911	ABC transporter signature motif; other site
414684010912	Walker B; other site
414684010913	D-loop; other site
414684010914	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
414684010915	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
414684010916	PhoD-like phosphatase; Region: PhoD; pfam09423
414684010917	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
414684010918	putative active site [active]
414684010919	putative metal binding site [ion binding]; other site
414684010920	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
414684010921	Transcriptional regulators [Transcription]; Region: MarR; COG1846
414684010922	MarR family; Region: MarR; pfam01047
414684010923	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
414684010924	catalytic residues [active]
414684010925	dimer interface [polypeptide binding]; other site
414684010926	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
414684010927	CoenzymeA binding site [chemical binding]; other site
414684010928	subunit interaction site [polypeptide binding]; other site
414684010929	PHB binding site; other site
414684010930	Protein of unknown function (DUF1330); Region: DUF1330; pfam07045
414684010931	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
414684010932	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
414684010933	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
414684010934	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
414684010935	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
414684010936	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
414684010937	HlyD family secretion protein; Region: HlyD_3; pfam13437
414684010938	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
414684010939	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
414684010940	putative substrate translocation pore; other site
414684010941	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
414684010942	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
414684010943	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
414684010944	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
414684010945	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
414684010946	substrate binding pocket [chemical binding]; other site
414684010947	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
414684010948	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
414684010949	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684010950	active site
414684010951	phosphorylation site [posttranslational modification]
414684010952	intermolecular recognition site; other site
414684010953	dimerization interface [polypeptide binding]; other site
414684010954	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
414684010955	DNA binding site [nucleotide binding]
414684010956	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
414684010957	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684010958	active site
414684010959	phosphorylation site [posttranslational modification]
414684010960	intermolecular recognition site; other site
414684010961	dimerization interface [polypeptide binding]; other site
414684010962	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
414684010963	Zn2+ binding site [ion binding]; other site
414684010964	Mg2+ binding site [ion binding]; other site
414684010965	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684010966	Response regulator receiver domain; Region: Response_reg; pfam00072
414684010967	active site
414684010968	phosphorylation site [posttranslational modification]
414684010969	intermolecular recognition site; other site
414684010970	dimerization interface [polypeptide binding]; other site
414684010971	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
414684010972	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
414684010973	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
414684010974	putative active site [active]
414684010975	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
414684010976	dimer interface [polypeptide binding]; other site
414684010977	phosphorylation site [posttranslational modification]
414684010978	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
414684010979	ATP binding site [chemical binding]; other site
414684010980	Mg2+ binding site [ion binding]; other site
414684010981	G-X-G motif; other site
414684010982	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684010983	Response regulator receiver domain; Region: Response_reg; pfam00072
414684010984	active site
414684010985	phosphorylation site [posttranslational modification]
414684010986	intermolecular recognition site; other site
414684010987	dimerization interface [polypeptide binding]; other site
414684010988	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
414684010989	Response regulator receiver domain; Region: Response_reg; pfam00072
414684010990	active site
414684010991	phosphorylation site [posttranslational modification]
414684010992	intermolecular recognition site; other site
414684010993	dimerization interface [polypeptide binding]; other site
414684010994	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
414684010995	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
414684010996	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684010997	dimer interface [polypeptide binding]; other site
414684010998	putative CheW interface [polypeptide binding]; other site
414684010999	Transcriptional regulator [Transcription]; Region: LysR; COG0583
414684011000	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
414684011001	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
414684011002	putative dimerization interface [polypeptide binding]; other site
414684011003	ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208
414684011004	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
414684011005	homodimer interface [polypeptide binding]; other site
414684011006	active site
414684011007	heterodimer interface [polypeptide binding]; other site
414684011008	catalytic residue [active]
414684011009	metal binding site [ion binding]; metal-binding site
414684011010	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
414684011011	multimerization interface [polypeptide binding]; other site
414684011012	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
414684011013	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
414684011014	substrate binding site [chemical binding]; other site
414684011015	hexamer interface [polypeptide binding]; other site
414684011016	metal binding site [ion binding]; metal-binding site
414684011017	probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880
414684011018	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
414684011019	Walker A motif; other site
414684011020	ATP binding site [chemical binding]; other site
414684011021	Walker B motif; other site
414684011022	arginine finger; other site
414684011023	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
414684011024	AMP binding site [chemical binding]; other site
414684011025	metal binding site [ion binding]; metal-binding site
414684011026	active site
414684011027	phosphoribulokinase; Provisional; Region: PRK15453
414684011028	transketolase; Reviewed; Region: PRK12753
414684011029	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
414684011030	TPP-binding site [chemical binding]; other site
414684011031	dimer interface [polypeptide binding]; other site
414684011032	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
414684011033	PYR/PP interface [polypeptide binding]; other site
414684011034	dimer interface [polypeptide binding]; other site
414684011035	TPP binding site [chemical binding]; other site
414684011036	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
414684011037	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
414684011038	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
414684011039	intersubunit interface [polypeptide binding]; other site
414684011040	active site
414684011041	zinc binding site [ion binding]; other site
414684011042	Na+ binding site [ion binding]; other site
414684011043	phosphoglycolate phosphatase; Provisional; Region: PRK13222
414684011044	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
414684011045	active site
414684011046	motif I; other site
414684011047	motif II; other site
414684011048	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
414684011049	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
414684011050	motif II; other site
414684011051	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
414684011052	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
414684011053	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
414684011054	ATP-grasp domain; Region: ATP-grasp; pfam02222
414684011055	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
414684011056	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
414684011057	NADP binding site [chemical binding]; other site
414684011058	active site
414684011059	putative substrate binding site [chemical binding]; other site
414684011060	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
414684011061	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
414684011062	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
414684011063	Probable Catalytic site; other site
414684011064	metal-binding site
414684011065	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
414684011066	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
414684011067	substrate binding pocket [chemical binding]; other site
414684011068	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
414684011069	membrane-bound complex binding site; other site
414684011070	hinge residues; other site
414684011071	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
414684011072	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
414684011073	substrate binding pocket [chemical binding]; other site
414684011074	membrane-bound complex binding site; other site
414684011075	hinge residues; other site
414684011076	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
414684011077	malate dehydrogenase; Reviewed; Region: PRK06223
414684011078	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
414684011079	NAD(P) binding site [chemical binding]; other site
414684011080	dimer interface [polypeptide binding]; other site
414684011081	tetramer (dimer of dimers) interface [polypeptide binding]; other site
414684011082	substrate binding site [chemical binding]; other site
414684011083	PRC-barrel domain; Region: PRC; pfam05239
414684011084	Methyltransferase domain; Region: Methyltransf_23; pfam13489
414684011085	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
414684011086	S-adenosylmethionine binding site [chemical binding]; other site
414684011087	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
414684011088	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
414684011089	hypothetical protein; Provisional; Region: PRK06034
414684011090	Chorismate mutase type II; Region: CM_2; smart00830
414684011091	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
414684011092	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
414684011093	pyridoxal 5'-phosphate binding site [chemical binding]; other site
414684011094	homodimer interface [polypeptide binding]; other site
414684011095	catalytic residue [active]
414684011096	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
414684011097	prephenate dehydrogenase; Validated; Region: PRK08507
414684011098	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
414684011099	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
414684011100	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
414684011101	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
414684011102	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
414684011103	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
414684011104	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
414684011105	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
414684011106	Transposase [DNA replication, recombination, and repair]; Region: COG5433
414684011107	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
414684011108	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
414684011109	putative active site pocket [active]
414684011110	dimerization interface [polypeptide binding]; other site
414684011111	putative catalytic residue [active]
414684011112	CHASE3 domain; Region: CHASE3; pfam05227
414684011113	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
414684011114	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
414684011115	dimer interface [polypeptide binding]; other site
414684011116	putative CheW interface [polypeptide binding]; other site
414684011117	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
414684011118	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
414684011119	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
414684011120	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
414684011121	TSCPD domain; Region: TSCPD; pfam12637
414684011122	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
414684011123	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
414684011124	putative acyl-acceptor binding pocket; other site
414684011125	Uncharacterized conserved protein [Function unknown]; Region: COG1434
414684011126	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
414684011127	putative active site [active]
414684011128	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
414684011129	zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719
414684011130	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
414684011131	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
414684011132	diaminopimelate decarboxylase; Region: lysA; TIGR01048
414684011133	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
414684011134	active site
414684011135	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
414684011136	substrate binding site [chemical binding]; other site
414684011137	catalytic residues [active]
414684011138	dimer interface [polypeptide binding]; other site
414684011139	argininosuccinate lyase; Provisional; Region: PRK00855
414684011140	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
414684011141	active sites [active]
414684011142	tetramer interface [polypeptide binding]; other site
414684011143	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
414684011144	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
414684011145	catalytic residues [active]
414684011146	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530
414684011147	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
414684011148	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
414684011149	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
414684011150	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
414684011151	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
414684011152	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
414684011153	Ligand binding site [chemical binding]; other site
414684011154	Electron transfer flavoprotein domain; Region: ETF; pfam01012
414684011155	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
414684011156	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
414684011157	nudix motif; other site
414684011158	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
414684011159	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
414684011160	active site
414684011161	HIGH motif; other site
414684011162	nucleotide binding site [chemical binding]; other site
414684011163	active site
414684011164	KMSKS motif; other site
414684011165	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
414684011166	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
414684011167	active site
414684011168	Uncharacterized conserved protein [Function unknown]; Region: COG2353
414684011169	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
414684011170	diiron binding motif [ion binding]; other site
414684011171	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
414684011172	Predicted membrane protein [Function unknown]; Region: COG1238
414684011173	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
414684011174	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
414684011175	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
414684011176	DNA binding residues [nucleotide binding]
414684011177	FecR protein; Region: FecR; pfam04773
414684011178	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
414684011179	Secretin and TonB N terminus short domain; Region: STN; smart00965
414684011180	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
414684011181	TonB-dependent siderophore receptor, pseudogene;identified by match to protein family HMM PF01553
414684011182	TonB dependent receptor, pseudogene